PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
11114158-8	2000	Supporting a functional role for Lys-239 in CtBP binding, mutation of this residue to Ala decreases the ability of E1A to block cAMP-regulated enhancer (CRE)-binding protein (CREB)-stimulated gene expression.	ctbp	44-48	cAMP responsive element binding protein 1	Homo sapiens	175-179
10995736-7	2000	Efficient repression of TGF-beta-activated gene responses by TGIF is dependent on interaction with CtBP, and we show that TGIF is able to recruit CtBP to a TGF-beta-activated Smad complex.	ctbp	99-103	TGFB induced factor homeobox 1	Homo sapiens	61-65
10995736-7	2000	Efficient repression of TGF-beta-activated gene responses by TGIF is dependent on interaction with CtBP, and we show that TGIF is able to recruit CtBP to a TGF-beta-activated Smad complex.	ctbp	99-103	TGFB induced factor homeobox 1	Homo sapiens	122-126
10995736-7	2000	Efficient repression of TGF-beta-activated gene responses by TGIF is dependent on interaction with CtBP, and we show that TGIF is able to recruit CtBP to a TGF-beta-activated Smad complex.	ctbp	146-150	TGFB induced factor homeobox 1	Homo sapiens	61-65
10995736-7	2000	Efficient repression of TGF-beta-activated gene responses by TGIF is dependent on interaction with CtBP, and we show that TGIF is able to recruit CtBP to a TGF-beta-activated Smad complex.	ctbp	146-150	TGFB induced factor homeobox 1	Homo sapiens	122-126
10995736-8	2000	Disruption of the PLDLS motif in TGIF abolishes the interaction of CtBP with TGIF and compromises the ability of TGIF to repress transcription.	ctbp	67-71	TGFB induced factor homeobox 1	Homo sapiens	33-37
10995736-8	2000	Disruption of the PLDLS motif in TGIF abolishes the interaction of CtBP with TGIF and compromises the ability of TGIF to repress transcription.	ctbp	67-71	TGFB induced factor homeobox 1	Homo sapiens	77-81
10995736-8	2000	Disruption of the PLDLS motif in TGIF abolishes the interaction of CtBP with TGIF and compromises the ability of TGIF to repress transcription.	ctbp	67-71	TGFB induced factor homeobox 1	Homo sapiens	77-81
10995736-9	2000	Thus, at least one HPE mutation in TGIF appears to prevent CtBP-dependent transcriptional repression by TGIF, suggesting an important developmental role for the recruitment of CtBP by TGIF.	ctbp	59-63	TGFB induced factor homeobox 1	Homo sapiens	35-39
10995736-9	2000	Thus, at least one HPE mutation in TGIF appears to prevent CtBP-dependent transcriptional repression by TGIF, suggesting an important developmental role for the recruitment of CtBP by TGIF.	ctbp	59-63	TGFB induced factor homeobox 1	Homo sapiens	104-108
10995736-9	2000	Thus, at least one HPE mutation in TGIF appears to prevent CtBP-dependent transcriptional repression by TGIF, suggesting an important developmental role for the recruitment of CtBP by TGIF.	ctbp	59-63	TGFB induced factor homeobox 1	Homo sapiens	104-108
10586885-0	1999	CtBP/BARS induces fission of Golgi membranes by acylating lysophosphatidic acid.	ctbp	0-4	C-terminal binding protein 1	Homo sapiens	5-9
10756202-2	2000	In the absence of Wnt signals, specific LEF/TCF isoforms repress rather than activate gene targets through recruitment of the co-repressor CtBP.	ctbp	139-143	hepatocyte nuclear factor 4 alpha	Homo sapiens	40-47
10756202-4	2000	Therefore LEF-1 is distinct from its TCF family members in that it cannot engage in activities specific to this isoform such as recruitment of the co-repressor CtBP.	ctbp	160-164	lymphoid enhancer binding factor 1	Homo sapiens	10-15
10704213-3	2000	Crystallographic studies of cTBP (i.e., TBP without the N-terminal domain) from various species and molecular biology studies of cTBP and mixed cTBP/TBP species have led to the view that DNA binding by TBP is regulated by TBP dimerization.	ctbp	28-32	TATA-binding protein	Saccharomyces cerevisiae S288C	40-43
10704213-3	2000	Crystallographic studies of cTBP (i.e., TBP without the N-terminal domain) from various species and molecular biology studies of cTBP and mixed cTBP/TBP species have led to the view that DNA binding by TBP is regulated by TBP dimerization.	ctbp	28-32	TATA-binding protein	Saccharomyces cerevisiae S288C	40-43
10704213-3	2000	Crystallographic studies of cTBP (i.e., TBP without the N-terminal domain) from various species and molecular biology studies of cTBP and mixed cTBP/TBP species have led to the view that DNA binding by TBP is regulated by TBP dimerization.	ctbp	28-32	TATA-binding protein	Saccharomyces cerevisiae S288C	40-43
10586885-3	1999	Here we show that CtBP/BARS, a protein that functions in the dynamics of Golgi tubules, is an essential component of the fission machinery operating at Golgi tubular networks, including Golgi compartments involved in protein transport and sorting.	ctbp	18-22	C-terminal binding protein 1	Homo sapiens	23-27
10586885-4	1999	CtBP/BARS-induced fission was preceded by the formation of constricted sites in Golgi tubules, whose extreme curvature is likely to involve local changes in the membrane lipid composition.	ctbp	0-4	C-terminal binding protein 1	Homo sapiens	5-9
10586885-5	1999	We find that CtBP/BARS uses acyl-CoA to selectively catalyse the acylation of lysophosphatidic acid to phosphatidic acid both in pure lipidic systems and in Golgi membranes, and that this reaction is essential for fission.	ctbp	13-17	C-terminal binding protein 1	Homo sapiens	18-22
10196224-4	1999	A known protein, CtIP, a co-repressor with CtBP, was found.	ctbp	43-47	RB binding protein 8, endonuclease	Homo sapiens	17-21
9811458-4	1998	The function of CtIP is unknown, but its reported association with a transcriptional repressor CtBP lends further support that it may have a role in transcription.	ctbp	95-99	RB binding protein 8, endonuclease	Homo sapiens	16-20
1446686-12	1992	Thioredoxin in the presence of 1 mM dithiothreitol activated CTBP; maximal binding was obtained with 4 microM thioredoxin.	ctbp	61-65	thioredoxin 1	Rattus norvegicus	0-11
9650586-3	1998	CtBP is shown here to bind the histone deacetylase HDAC1, suggesting that a promoter targeted CtBP-HDAC1 complex can silence transcription from the PCNA promoter through a deacetylation mechanism.	ctbp	0-4	histone deacetylase 1	Homo sapiens	51-56
9650586-3	1998	CtBP is shown here to bind the histone deacetylase HDAC1, suggesting that a promoter targeted CtBP-HDAC1 complex can silence transcription from the PCNA promoter through a deacetylation mechanism.	ctbp	0-4	histone deacetylase 1	Homo sapiens	99-104
9650586-3	1998	CtBP is shown here to bind the histone deacetylase HDAC1, suggesting that a promoter targeted CtBP-HDAC1 complex can silence transcription from the PCNA promoter through a deacetylation mechanism.	ctbp	0-4	proliferating cell nuclear antigen	Homo sapiens	148-152
9417053-5	1998	Amino acid sequences from six peptides derived from pure CTBP matched sequences in transcytosis-associated protein (TAP) with 98% identity.	ctbp	57-61	USO1 vesicle transport factor	Rattus norvegicus	83-114
1446686-12	1992	Thioredoxin in the presence of 1 mM dithiothreitol activated CTBP; maximal binding was obtained with 4 microM thioredoxin.	ctbp	61-65	thioredoxin 1	Rattus norvegicus	110-121
32620870-5	2020	We show that Zeb1 is an important factor promoting vascular EC proliferation and corneal NV; and a couple of small molecule inhibitors can evict Ctbp from the Zeb1-Ctbp complex, thereby reducing EC Zeb1 expression, proliferation, and corneal NV.	ctbp	145-149	zinc finger E-box binding homeobox 1	Homo sapiens	13-17
32620870-5	2020	We show that Zeb1 is an important factor promoting vascular EC proliferation and corneal NV; and a couple of small molecule inhibitors can evict Ctbp from the Zeb1-Ctbp complex, thereby reducing EC Zeb1 expression, proliferation, and corneal NV.	ctbp	145-149	zinc finger E-box binding homeobox 1	Homo sapiens	159-163
32620870-5	2020	We show that Zeb1 is an important factor promoting vascular EC proliferation and corneal NV; and a couple of small molecule inhibitors can evict Ctbp from the Zeb1-Ctbp complex, thereby reducing EC Zeb1 expression, proliferation, and corneal NV.	ctbp	145-149	zinc finger E-box binding homeobox 1	Homo sapiens	159-163
32620870-5	2020	We show that Zeb1 is an important factor promoting vascular EC proliferation and corneal NV; and a couple of small molecule inhibitors can evict Ctbp from the Zeb1-Ctbp complex, thereby reducing EC Zeb1 expression, proliferation, and corneal NV.	ctbp	164-168	zinc finger E-box binding homeobox 1	Homo sapiens	159-163
32620870-5	2020	We show that Zeb1 is an important factor promoting vascular EC proliferation and corneal NV; and a couple of small molecule inhibitors can evict Ctbp from the Zeb1-Ctbp complex, thereby reducing EC Zeb1 expression, proliferation, and corneal NV.	ctbp	164-168	zinc finger E-box binding homeobox 1	Homo sapiens	159-163
30442980-0	2019	CtBP promotes metastasis of breast cancer through repressing cholesterol and activating TGF-beta signaling.	ctbp	0-4	transforming growth factor beta 1	Homo sapiens	88-96
32332713-8	2020	Collectively, this study identifies CtBP1 and 2 as potent repressors of DR4/5 expression and activity, and supports the targeting of CtBP as a promising therapeutic strategy for HGSOC.	ctbp	36-40	TNF receptor superfamily member 10a	Homo sapiens	72-77
30478995-2	2019	In this study, we show that knockdown of CtIP, a corepressor of CtBP, promotes cell proliferation and alleviates G2/M phase arrest in etoposide (Eto)-treated HCT116 cells.	ctbp	64-68	RB binding protein 8, endonuclease	Homo sapiens	41-45
31281524-4	2019	Results: We found an inverse correlation between estrogen signaling and HRR activity in EOC, and the genome-wide collaboration between ERalpha and the co-repressor CtBP.	ctbp	164-168	estrogen receptor 1	Homo sapiens	135-142
30442980-5	2019	We found that CtBP regulates intracellular cholesterol homeostasis in breast cancer cells by forming a complex with ZEB1 and transcriptionally repressing SREBF2 expression.	ctbp	14-18	sterol regulatory element binding transcription factor 2	Homo sapiens	154-160
30442980-5	2019	We found that CtBP regulates intracellular cholesterol homeostasis in breast cancer cells by forming a complex with ZEB1 and transcriptionally repressing SREBF2 expression.	ctbp	14-18	zinc finger E-box binding homeobox 1	Homo sapiens	116-120
30442980-9	2019	Thus, we propose a feedback loop formed by CtBP, cholesterol, and TGF-beta signaling pathway, through which TGF-beta triggers the cascade that mobilizes the cancer cells for metastasis.	ctbp	43-47	transforming growth factor beta 1	Homo sapiens	108-116
28935892-6	2017	Changes in the NADH:NAD+ ratio regulate CtBP binding to the acetyltransferase p300, and regulate binding of p300 and the transcription factor NF-kappaB to pro-inflammatory gene promoters.	ctbp	40-44	E1A binding protein p300	Homo sapiens	78-82
29879296-2	2018	Overexpression of CtBP occurs in many human cancers where they promote the epithelial-to-mesenchymal transition, stem cell-like features, and cell survival, while knockdown of CtBP in tumor cells results in p53-independent apoptosis.	ctbp	176-180	tumor protein p53	Homo sapiens	207-210
29879296-9	2018	Finally, the constitutive expression of one such peptide, Pep1-E1A-WT, in a melanoma cell line reverses CtBP-mediated oncogenic phenotypes including proliferation, migration, and sphere formation and limits tumor growth in vivo.	ctbp	104-108	CNDP dipeptidase 2 (metallopeptidase M20 family)	Mus musculus	58-62
29219210-6	2018	These effects are mediated through CtBP, an NADH-sensitive transcriptional co-repressor; through effects on NLRP3 inflammasome assembly and caspase-1 activation; through formation of advanced glycation end-products; and by less well-defined mechanisms.	ctbp	35-39	NLR family pyrin domain containing 3	Homo sapiens	108-113
29219210-6	2018	These effects are mediated through CtBP, an NADH-sensitive transcriptional co-repressor; through effects on NLRP3 inflammasome assembly and caspase-1 activation; through formation of advanced glycation end-products; and by less well-defined mechanisms.	ctbp	35-39	caspase 1	Homo sapiens	140-149
29540733-3	2018	Glutamine is mainly metabolized through the glutaminolysis pathway and our previous report indicated that CtBP increases GDH activity and promotes glutaminolysis through repressing the expression of SIRT4, a well-known mitochondrion-located factor that inhibits glutaminolysis pathway.	ctbp	106-110	glutamate dehydrogenase 1	Homo sapiens	121-124
29540733-3	2018	Glutamine is mainly metabolized through the glutaminolysis pathway and our previous report indicated that CtBP increases GDH activity and promotes glutaminolysis through repressing the expression of SIRT4, a well-known mitochondrion-located factor that inhibits glutaminolysis pathway.	ctbp	106-110	sirtuin 4	Homo sapiens	199-204
29540733-4	2018	CtBP is known to be a sensor of intracellular metabolic status; we thus hypothesized that a consensus CtBP-SIRT4-GDH axis may mediate the crosstalk between glycolysis and glutaminolysis.	ctbp	0-4	sirtuin 4	Homo sapiens	107-112
29540733-4	2018	CtBP is known to be a sensor of intracellular metabolic status; we thus hypothesized that a consensus CtBP-SIRT4-GDH axis may mediate the crosstalk between glycolysis and glutaminolysis.	ctbp	0-4	glutamate dehydrogenase 1	Homo sapiens	113-116
29540733-4	2018	CtBP is known to be a sensor of intracellular metabolic status; we thus hypothesized that a consensus CtBP-SIRT4-GDH axis may mediate the crosstalk between glycolysis and glutaminolysis.	ctbp	102-106	sirtuin 4	Homo sapiens	107-112
29540733-4	2018	CtBP is known to be a sensor of intracellular metabolic status; we thus hypothesized that a consensus CtBP-SIRT4-GDH axis may mediate the crosstalk between glycolysis and glutaminolysis.	ctbp	102-106	glutamate dehydrogenase 1	Homo sapiens	113-116
29540733-6	2018	This coordination was found to be related to CtBP repression activity on SIRT4 expression under high level of glucose but not low glucose level.	ctbp	45-49	sirtuin 4	Homo sapiens	73-78
29540733-7	2018	Low level of glucose supply was found to decrease GDH activity via blocking CtBP dimerization.	ctbp	76-80	glutamate dehydrogenase 1	Homo sapiens	50-53
29540733-8	2018	Mechanically, low glucose also abolished CtBP binding to SIRT4 promoter and the repression of SIRT4 expression.	ctbp	41-45	sirtuin 4	Homo sapiens	57-62
29540733-9	2018	Consistently, the CtBP dimerization inhibitor MTOB mimicked low glucose effects on SIRT4 expression, and GDH activity suggest that CtBP requires high glucose supply to act as a suppressor of SIRT4 gene.	ctbp	18-22	sirtuin 4	Homo sapiens	83-88
29540733-9	2018	Consistently, the CtBP dimerization inhibitor MTOB mimicked low glucose effects on SIRT4 expression, and GDH activity suggest that CtBP requires high glucose supply to act as a suppressor of SIRT4 gene.	ctbp	18-22	sirtuin 4	Homo sapiens	191-196
28853286-7	2017	TBL1Y knockdown may have negatively impacted cardiogenesis by CtBP stabilization.	ctbp	62-66	transducin beta like 1 Y-linked	Homo sapiens	0-5
28935892-3	2017	Here, we show that glucose metabolism regulates pro-inflammatory NF-kappaB transcriptional activity through effects on the cytosolic NADH:NAD+ ratio and the NAD(H) sensitive transcriptional co-repressor CtBP.	ctbp	203-207	nuclear factor kappa B subunit 1	Homo sapiens	65-74
30296269-3	2018	Here, through a genetic screen in Arabidopsis thaliana, we demonstrated that loss-of-function mutations in ANGUSTIFOLIA (AN), which encodes for a homolog of mammalian CtBP/BARs, displayed conical cells phenotype with wider tip angles, correlating with increased accumulation of reactive oxygen species (ROS).	ctbp	167-171	NAD(P)-binding Rossmann-fold superfamily protein	Arabidopsis thaliana	107-119
30296269-3	2018	Here, through a genetic screen in Arabidopsis thaliana, we demonstrated that loss-of-function mutations in ANGUSTIFOLIA (AN), which encodes for a homolog of mammalian CtBP/BARs, displayed conical cells phenotype with wider tip angles, correlating with increased accumulation of reactive oxygen species (ROS).	ctbp	167-171	C-terminal binding protein 1	Homo sapiens	172-176
29540733-9	2018	Consistently, the CtBP dimerization inhibitor MTOB mimicked low glucose effects on SIRT4 expression, and GDH activity suggest that CtBP requires high glucose supply to act as a suppressor of SIRT4 gene.	ctbp	131-135	glutamate dehydrogenase 1	Homo sapiens	105-108
29540733-9	2018	Consistently, the CtBP dimerization inhibitor MTOB mimicked low glucose effects on SIRT4 expression, and GDH activity suggest that CtBP requires high glucose supply to act as a suppressor of SIRT4 gene.	ctbp	131-135	sirtuin 4	Homo sapiens	191-196
29540733-10	2018	In conclusion, we propose that a general molecular pathway composed by CtBP-SIRT4-GDH coordinating the metabolism of glucose and glutamine in cancer cells.	ctbp	71-75	sirtuin 4	Homo sapiens	76-81
29540733-10	2018	In conclusion, we propose that a general molecular pathway composed by CtBP-SIRT4-GDH coordinating the metabolism of glucose and glutamine in cancer cells.	ctbp	71-75	glutamate dehydrogenase 1	Homo sapiens	82-85
23974101-4	2013	Further, E2F-7 recruits CtBP and HDAC to the damaged DNA, altering the local chromatin environment of the DNA lesion.	ctbp	24-28	E2F transcription factor 7	Homo sapiens	9-14
25728771-0	2015	MCRIP1, an ERK substrate, mediates ERK-induced gene silencing during epithelial-mesenchymal transition by regulating the co-repressor CtBP.	ctbp	134-138	MAPK regulated corepressor interacting protein 1	Homo sapiens	0-6
25728771-0	2015	MCRIP1, an ERK substrate, mediates ERK-induced gene silencing during epithelial-mesenchymal transition by regulating the co-repressor CtBP.	ctbp	134-138	mitogen-activated protein kinase 1	Homo sapiens	11-14
25728771-0	2015	MCRIP1, an ERK substrate, mediates ERK-induced gene silencing during epithelial-mesenchymal transition by regulating the co-repressor CtBP.	ctbp	134-138	mitogen-activated protein kinase 1	Homo sapiens	35-38
25728771-4	2015	However, the functional relationship between ERK signaling and CtBP is unknown.	ctbp	63-67	mitogen-activated protein kinase 1	Homo sapiens	45-48
25728771-5	2015	Here, we identified an ERK substrate, designated MCRIP1, which bridges ERK signaling and CtBP-mediated gene silencing.	ctbp	89-93	mitogen-activated protein kinase 1	Homo sapiens	23-26
25728771-5	2015	Here, we identified an ERK substrate, designated MCRIP1, which bridges ERK signaling and CtBP-mediated gene silencing.	ctbp	89-93	MAPK regulated corepressor interacting protein 1	Homo sapiens	49-55
25728771-7	2015	We found that MCRIP1 binds to CtBP, thereby competitively inhibiting CtBP-ZEB1 interaction.	ctbp	30-34	MAPK regulated corepressor interacting protein 1	Homo sapiens	14-20
25728771-7	2015	We found that MCRIP1 binds to CtBP, thereby competitively inhibiting CtBP-ZEB1 interaction.	ctbp	30-34	zinc finger E-box binding homeobox 1	Homo sapiens	74-78
25728771-7	2015	We found that MCRIP1 binds to CtBP, thereby competitively inhibiting CtBP-ZEB1 interaction.	ctbp	69-73	MAPK regulated corepressor interacting protein 1	Homo sapiens	14-20
25728771-7	2015	We found that MCRIP1 binds to CtBP, thereby competitively inhibiting CtBP-ZEB1 interaction.	ctbp	69-73	zinc finger E-box binding homeobox 1	Homo sapiens	74-78
25368327-7	2014	These results reveal a novel function for TFIIIA as a negative regulator that recruits histone modification activity through the CtBP repressor complex exclusively to the oocyte-type 5 S rRNA genes, leading to their terminal repression.	ctbp	129-133	general transcription factor 3A L homeolog	Xenopus laevis	42-48
25301737-6	2014	We found that Ikaros interacted with CtBP as a transcription repressor complex, which inhibited CD133 expression in HCC.	ctbp	37-41	IKAROS family zinc finger 1	Homo sapiens	14-20
25301737-6	2014	We found that Ikaros interacted with CtBP as a transcription repressor complex, which inhibited CD133 expression in HCC.	ctbp	37-41	prominin 1	Homo sapiens	96-101
25088415-6	2014	High oxygen promotes a decrease in the CtBP occupancy of the promoter of Hes1.	ctbp	39-43	hes family bHLH transcription factor 1	Homo sapiens	73-77
25088415-7	2014	Furthermore, under conditions of high oxygen and BMP, CtBP associates with HES1 and represses neurogenesis.	ctbp	54-58	bone morphogenetic protein 1	Homo sapiens	49-52
25088415-7	2014	Furthermore, under conditions of high oxygen and BMP, CtBP associates with HES1 and represses neurogenesis.	ctbp	54-58	hes family bHLH transcription factor 1	Homo sapiens	75-79
25088415-8	2014	We propose that CtBP integrates signals originating from microenvironmental levels of oxygen and BMP to confer nonneurogenic character to the roof plate region.	ctbp	16-20	bone morphogenetic protein 1	Homo sapiens	97-100
24732800-0	2014	CtBP and associated LSD1 are required for transcriptional activation by NeuroD1 in gastrointestinal endocrine cells.	ctbp	0-4	neuronal differentiation 1	Homo sapiens	72-79
24732800-7	2014	The secretin, beta-glucokinase, insulin I, and insulin II genes, four known direct targets of NeuroD1 in intestinal and pancreatic endocrine cells, all show similar promoter occupancy by CtBP-associated proteins and PCAF, with acetylation of H3K9.	ctbp	187-191	neuronal differentiation 1	Homo sapiens	94-101
25728771-8	2015	When phosphorylated by ERK, MCRIP1 dissociates from CtBP, allowing CtBP to interact with ZEB1.	ctbp	52-56	mitogen-activated protein kinase 1	Homo sapiens	23-26
25728771-8	2015	When phosphorylated by ERK, MCRIP1 dissociates from CtBP, allowing CtBP to interact with ZEB1.	ctbp	52-56	MAPK regulated corepressor interacting protein 1	Homo sapiens	28-34
25728771-8	2015	When phosphorylated by ERK, MCRIP1 dissociates from CtBP, allowing CtBP to interact with ZEB1.	ctbp	52-56	zinc finger E-box binding homeobox 1	Homo sapiens	89-93
25728771-8	2015	When phosphorylated by ERK, MCRIP1 dissociates from CtBP, allowing CtBP to interact with ZEB1.	ctbp	67-71	mitogen-activated protein kinase 1	Homo sapiens	23-26
25728771-8	2015	When phosphorylated by ERK, MCRIP1 dissociates from CtBP, allowing CtBP to interact with ZEB1.	ctbp	67-71	MAPK regulated corepressor interacting protein 1	Homo sapiens	28-34
25728771-8	2015	When phosphorylated by ERK, MCRIP1 dissociates from CtBP, allowing CtBP to interact with ZEB1.	ctbp	67-71	zinc finger E-box binding homeobox 1	Homo sapiens	89-93
25728771-9	2015	In this manner, the CtBP co-repressor complex is recruited to, and silences, the E-cadherin promoter by inducing chromatin modifications.	ctbp	20-24	cadherin 1	Homo sapiens	81-91
24240237-6	2013	Multidimensional protein identification technology (MudPIT) proteomics of multiple Wnt regulatory complexes reveals that alpha-catenin binds with beta-catenin to LEF-1/TCF DNA-binding proteins in Wnt3a signaling cells and recruits APC in a complex with the CtBP:CoREST:LSD1 histone H3K4 demethylase to regulate transcription and beta-catenin occupancy at Wnt target genes.	ctbp	257-261	catenin beta 1	Homo sapiens	146-158
24240237-6	2013	Multidimensional protein identification technology (MudPIT) proteomics of multiple Wnt regulatory complexes reveals that alpha-catenin binds with beta-catenin to LEF-1/TCF DNA-binding proteins in Wnt3a signaling cells and recruits APC in a complex with the CtBP:CoREST:LSD1 histone H3K4 demethylase to regulate transcription and beta-catenin occupancy at Wnt target genes.	ctbp	257-261	APC regulator of WNT signaling pathway	Homo sapiens	231-234
23264848-2	2012	We reported previously that CtBP stimulates cell migration in certain contexts via repression of PTEN transcription and activation of the phosphatidylinositol 3-kinase (PI3K) pathway.	ctbp	28-32	phosphatase and tensin homolog	Homo sapiens	97-101
23864635-0	2013	Dissection of the C-terminal region of E1A redefines the roles of CtBP and other cellular targets in oncogenic transformation.	ctbp	66-70	branched chain keto acid dehydrogenase E1 subunit alpha	Rattus norvegicus	39-42
23864635-6	2013	Previous analysis has suggested that the interaction of E1A with CtBP plays a pivotal role in both activities.	ctbp	65-69	branched chain keto acid dehydrogenase E1 subunit alpha	Rattus norvegicus	56-59
23864635-7	2013	However, some C-terminal mutants of E1A retain CtBP binding and yet exhibit defects in transformation, suggesting that other targets of this region are also necessary.	ctbp	47-51	branched chain keto acid dehydrogenase E1 subunit alpha	Rattus norvegicus	36-39
23864635-11	2013	Interaction of E1A with importin alpha3/Qip1, dual-specificity tyrosine-regulated kinase 1A (DYRK1A), HAN11, and CtBP influenced transformation with E1B-55K.	ctbp	113-117	branched chain keto acid dehydrogenase E1 subunit alpha	Rattus norvegicus	15-18
23169233-3	2013	HIPK2 is activated by the checkpoint kinase ATM, and triggers apoptosis through regulatory phosphorylation of a set of cellular key molecules including the tumour suppressor p53 and the anti-apoptotic corepressor CtBP.	ctbp	213-217	homeodomain interacting protein kinase 2	Homo sapiens	0-5
23291169-2	2013	It was reported that glucose withdrawal causes induction of Bax due to the dissociation of CtBP from the Bax promoter.	ctbp	91-95	BCL2 associated X, apoptosis regulator	Homo sapiens	60-63
23264848-8	2012	An analysis of the Tiam1 promoter revealed binding sites for the CtBP-interacting Kruppel-like factor 8 (KLF8), and a Tiam1 promoter luciferase reporter was induced in the presence of both KLF8 and CtBP2, consistent with KLF8-dependent CtBP transactivation of Tiam1.	ctbp	65-69	Kruppel like factor 8	Homo sapiens	189-193
23264848-3	2012	We have now identified an additional and direct mechanism for CtBP stimulation of cell migration via regulation of T-cell lymphoma invasion and metastasis 1 (Tiam1) protein.	ctbp	62-66	TIAM Rac1 associated GEF 1	Homo sapiens	115-156
23264848-8	2012	An analysis of the Tiam1 promoter revealed binding sites for the CtBP-interacting Kruppel-like factor 8 (KLF8), and a Tiam1 promoter luciferase reporter was induced in the presence of both KLF8 and CtBP2, consistent with KLF8-dependent CtBP transactivation of Tiam1.	ctbp	65-69	C-terminal binding protein 2	Homo sapiens	198-203
23264848-8	2012	An analysis of the Tiam1 promoter revealed binding sites for the CtBP-interacting Kruppel-like factor 8 (KLF8), and a Tiam1 promoter luciferase reporter was induced in the presence of both KLF8 and CtBP2, consistent with KLF8-dependent CtBP transactivation of Tiam1.	ctbp	65-69	Kruppel like factor 8	Homo sapiens	189-193
23264848-3	2012	We have now identified an additional and direct mechanism for CtBP stimulation of cell migration via regulation of T-cell lymphoma invasion and metastasis 1 (Tiam1) protein.	ctbp	62-66	TIAM Rac1 associated GEF 1	Homo sapiens	158-163
23264848-5	2012	We noted a strict positive correlation between CtBP2 and Tiam1 expression levels and that CtBP promotion of cell migration required CtBP-dependent transcriptional activation of Tiam1.	ctbp	90-94	TIAM Rac1 associated GEF 1	Homo sapiens	177-182
23264848-8	2012	An analysis of the Tiam1 promoter revealed binding sites for the CtBP-interacting Kruppel-like factor 8 (KLF8), and a Tiam1 promoter luciferase reporter was induced in the presence of both KLF8 and CtBP2, consistent with KLF8-dependent CtBP transactivation of Tiam1.	ctbp	65-69	TIAM Rac1 associated GEF 1	Homo sapiens	19-24
23264848-8	2012	An analysis of the Tiam1 promoter revealed binding sites for the CtBP-interacting Kruppel-like factor 8 (KLF8), and a Tiam1 promoter luciferase reporter was induced in the presence of both KLF8 and CtBP2, consistent with KLF8-dependent CtBP transactivation of Tiam1.	ctbp	65-69	Kruppel like factor 8	Homo sapiens	105-109
21199918-7	2011	Interestingly, knockdown of homeodomain-interacting protein kinase 2 (HIPK2), a CtBP stability modulator, increased CtBP2 levels, suppressed expression of Mitf, REST, and melanocyte differentiation, and increased neuronal gene expression and sympathoadrenal lineage differentiation.	ctbp	80-84	homeodomain interacting protein kinase 2	Mus musculus	28-68
21516122-7	2011	L-G3 cells expressing MEL1S, and bearing mutated CIM and SM differentiated into granulocytes in response to G-CSF; this indicated that both the SUMO modification at lysine 568 and CtBP binding were required for MEL1S-mediated transcriptional repression and blockade of differentiation, which might be relevant for the process of leukemogenesis.	ctbp	180-184	PR/SET domain 16	Homo sapiens	22-27
22315224-4	2012	HIC1 encodes a transcriptional repressor with five C(2)H(2) zinc fingers mediating sequence-specific DNA binding and two repression domains: an N-terminal BTB/POZ domain and a central region recruiting CtBP and NuRD complexes.	ctbp	202-206	HIC ZBTB transcriptional repressor 1	Homo sapiens	0-4
21516122-0	2011	Sumoylation of MEL1S at lysine 568 and its interaction with CtBP facilitates its repressor activity and the blockade of G-CSF-induced myeloid differentiation.	ctbp	60-64	PR/SET domain 16	Homo sapiens	15-20
21516122-0	2011	Sumoylation of MEL1S at lysine 568 and its interaction with CtBP facilitates its repressor activity and the blockade of G-CSF-induced myeloid differentiation.	ctbp	60-64	colony stimulating factor 3	Homo sapiens	120-125
21516122-5	2011	The expression of MEL1S containing mutated CtBP-interacting motif (CIM) in L-G3 cells still blocked the myeloid differentiation induced by G-CSF.	ctbp	43-47	PR/SET domain 16	Homo sapiens	18-23
21516122-5	2011	The expression of MEL1S containing mutated CtBP-interacting motif (CIM) in L-G3 cells still blocked the myeloid differentiation induced by G-CSF.	ctbp	43-47	colony stimulating factor 3	Homo sapiens	139-144
21315774-5	2011	Since the E-cadherin promoter is a target of CtBP-mediated repression, the relationship between ataxin-1 and the E-cadherin promoter was investigated.	ctbp	45-49	cadherin 1	Homo sapiens	10-20
21199918-7	2011	Interestingly, knockdown of homeodomain-interacting protein kinase 2 (HIPK2), a CtBP stability modulator, increased CtBP2 levels, suppressed expression of Mitf, REST, and melanocyte differentiation, and increased neuronal gene expression and sympathoadrenal lineage differentiation.	ctbp	80-84	homeodomain interacting protein kinase 2	Mus musculus	70-75
21199918-7	2011	Interestingly, knockdown of homeodomain-interacting protein kinase 2 (HIPK2), a CtBP stability modulator, increased CtBP2 levels, suppressed expression of Mitf, REST, and melanocyte differentiation, and increased neuronal gene expression and sympathoadrenal lineage differentiation.	ctbp	80-84	C-terminal binding protein 2	Mus musculus	116-121
21416054-1	2011	KLF8 regulates target genes by recruiting the p300 and PCAF co-activators via glutamines (Q) 118 and 248, the CtBP co-repressor to 86PVDLS90 or SUMO to lysine (K) 67.	ctbp	110-114	Kruppel like factor 8	Homo sapiens	0-4
21416054-6	2011	Interestingly, CtBP promoted sumoylation at K67 of wild-type but not AVALF mutant KLF8, and KLF8 interaction with CtBP was inhibited by treatment with the HDAC inhibitors, ectopic expression of the co-activators, or K93Q or K95Q mutation.	ctbp	114-118	Kruppel like factor 8	Homo sapiens	92-96
21416054-7	2011	Promoter reporter assays showed that CtBP inhibited KLF8 transactivity which was rescued by PCAF or p300 expresson.	ctbp	37-41	Kruppel like factor 8	Homo sapiens	52-56
21416054-7	2011	Promoter reporter assays showed that CtBP inhibited KLF8 transactivity which was rescued by PCAF or p300 expresson.	ctbp	37-41	lysine acetyltransferase 2B	Homo sapiens	92-96
21416054-7	2011	Promoter reporter assays showed that CtBP inhibited KLF8 transactivity which was rescued by PCAF or p300 expresson.	ctbp	37-41	E1A binding protein p300	Homo sapiens	100-104
21416054-9	2011	Taken together, these results identified a novel mechanism by which co-activators promote KLF8 transactivity by competing with SUMO for K67 modification and by acetylating K93 and K95 to inhibit CtBP-induced K67 sumoylation.	ctbp	195-199	Kruppel like factor 8	Homo sapiens	90-94
20548956-0	2010	Epigenetic repression of p16(INK4A) by latent Epstein-Barr virus requires the interaction of EBNA3A and EBNA3C with CtBP.	ctbp	116-120	cyclin dependent kinase inhibitor 2A	Homo sapiens	25-28
20835243-0	2010	Control of endothelial sprouting by a Tel-CtBP complex.	ctbp	42-46	ETS variant transcription factor 6	Homo sapiens	38-41
20835243-2	2010	Tel orchestrates endothelial sprouting by binding to the generic co-repressor, CtBP.	ctbp	79-83	ETS variant transcription factor 6	Homo sapiens	0-3
20547759-4	2010	CtBP is also required for the oncogenic potential of BCL-3 and for its ability to inhibit UV-mediated cell apoptosis in keratinocytes.	ctbp	0-4	BCL3 transcription coactivator	Homo sapiens	53-58
20418909-3	2010	In this study, we show that ZEB1 interacts with the SWI/SNF chromatin-remodeling protein BRG1 to regulate E-cadherin independently of CtBP, its traditional co-repressor.	ctbp	134-138	zinc finger E-box binding homeobox 1	Homo sapiens	28-32
20418909-3	2010	In this study, we show that ZEB1 interacts with the SWI/SNF chromatin-remodeling protein BRG1 to regulate E-cadherin independently of CtBP, its traditional co-repressor.	ctbp	134-138	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	89-93
20713352-4	2010	We found that the ZBRK1 promoter contains an authentic E2F-recognition sequence that specifically binds E2F1, but not E2F4 or E2F6, together with chromatin remodeling proteins CtIP and CtBP to form a repression complex that suppresses ZBRK1 transcription.	ctbp	185-189	zinc finger protein 350	Homo sapiens	18-23
20548956-0	2010	Epigenetic repression of p16(INK4A) by latent Epstein-Barr virus requires the interaction of EBNA3A and EBNA3C with CtBP.	ctbp	116-120	cyclin dependent kinase inhibitor 2A	Homo sapiens	29-34
20548956-0	2010	Epigenetic repression of p16(INK4A) by latent Epstein-Barr virus requires the interaction of EBNA3A and EBNA3C with CtBP.	ctbp	116-120	EBNA3A	Human gammaherpesvirus 4	93-99
20548956-0	2010	Epigenetic repression of p16(INK4A) by latent Epstein-Barr virus requires the interaction of EBNA3A and EBNA3C with CtBP.	ctbp	116-120	EBNA-3C	Human gammaherpesvirus 4	104-110
20548956-5	2010	Since binding to the co-repressor of transcription CtBP has been linked to the oncogenic activity of EBNA3A and EBNA3C, we established LCLs with recombinant viruses encoding EBNA3A- and/or EBNA3C-mutants that no longer bind CtBP.	ctbp	51-55	EBNA3A	Human gammaherpesvirus 4	101-107
20548956-6	2010	These novel LCLs have revealed that the chromatin remodelling and epigenetic repression of p16(INK4A) requires the interaction of both EBNA3A and EBNA3C with CtBP.	ctbp	158-162	cyclin dependent kinase inhibitor 2A	Homo sapiens	91-94
20548956-6	2010	These novel LCLs have revealed that the chromatin remodelling and epigenetic repression of p16(INK4A) requires the interaction of both EBNA3A and EBNA3C with CtBP.	ctbp	158-162	cyclin dependent kinase inhibitor 2A	Homo sapiens	95-100
20548956-6	2010	These novel LCLs have revealed that the chromatin remodelling and epigenetic repression of p16(INK4A) requires the interaction of both EBNA3A and EBNA3C with CtBP.	ctbp	158-162	EBNA3A	Human gammaherpesvirus 4	135-141
20548956-6	2010	These novel LCLs have revealed that the chromatin remodelling and epigenetic repression of p16(INK4A) requires the interaction of both EBNA3A and EBNA3C with CtBP.	ctbp	158-162	EBNA-3C	Human gammaherpesvirus 4	146-152
19890057-7	2009	RREB-1 protein, specifically in HLA-G-negative cells, interacts with subunits of CtBP complex implicated in chromatin remodeling.	ctbp	81-85	ras responsive element binding protein 1	Homo sapiens	0-6
20098713-8	2010	Pc2 forms distinct sub-nuclear foci, termed polycomb bodies, and can recruit partner proteins, such as the corepressor CtBP.	ctbp	119-123	chromobox 4	Homo sapiens	0-3
20098713-9	2010	We demonstrate that mutation of the SIMs in Pc2 prevents Pc2-dependent CtBP sumoylation, and decreases enrichment of SUMO1 and SUMO2 at polycomb foci.	ctbp	71-75	chromobox 4	Homo sapiens	44-47
20098713-9	2010	We demonstrate that mutation of the SIMs in Pc2 prevents Pc2-dependent CtBP sumoylation, and decreases enrichment of SUMO1 and SUMO2 at polycomb foci.	ctbp	71-75	chromobox 4	Homo sapiens	57-60
19890057-7	2009	RREB-1 protein, specifically in HLA-G-negative cells, interacts with subunits of CtBP complex implicated in chromatin remodeling.	ctbp	81-85	major histocompatibility complex, class I, G	Homo sapiens	32-37
18676825-6	2008	Loss of CtBP-mediated repression diminished the Polycomb-based epigenetic histone mark that is reported to favor silencing of p16 via DNA methylation.	ctbp	8-12	cyclin dependent kinase inhibitor 2A	Homo sapiens	126-129
19342888-1	2009	CtIP, CtBP-interacting protein, is a nuclear protein that was identified as a cofactor for the transcriptional repressor CtBP.	ctbp	6-10	RB binding protein 8, endonuclease	Homo sapiens	0-4
19352540-7	2009	Besides, these inhibitory Smad proteins also inhibit TGF-beta/BMP signaling in the nucleus by interacting with transcriptional repressors, such as histone deacetylases, Hoxc-8, and CtBP, or disrupting the formation of the TGF-beta-induced functional Smad-DNA complexes.	ctbp	181-185	SMAD family member 6	Homo sapiens	26-30
19352540-7	2009	Besides, these inhibitory Smad proteins also inhibit TGF-beta/BMP signaling in the nucleus by interacting with transcriptional repressors, such as histone deacetylases, Hoxc-8, and CtBP, or disrupting the formation of the TGF-beta-induced functional Smad-DNA complexes.	ctbp	181-185	transforming growth factor beta 1	Homo sapiens	53-61
19199812-4	2009	The energetic patterns for hTBP and cTBP suggest that the 158-amino acid NTD in hTBP does not initially occupy the DNA binding pocket.	ctbp	36-40	TATA-box binding protein	Homo sapiens	80-84
19928349-7	2009	This down-regulation of nuclear beta-catenin activity by APC most likely involves nuclear sequestration of beta-catenin from the transcription complex as well as interaction of APC with transcription corepressor CtBP.	ctbp	212-216	catenin beta 1	Homo sapiens	32-44
19928349-7	2009	This down-regulation of nuclear beta-catenin activity by APC most likely involves nuclear sequestration of beta-catenin from the transcription complex as well as interaction of APC with transcription corepressor CtBP.	ctbp	212-216	APC regulator of WNT signaling pathway	Homo sapiens	57-60
19928349-7	2009	This down-regulation of nuclear beta-catenin activity by APC most likely involves nuclear sequestration of beta-catenin from the transcription complex as well as interaction of APC with transcription corepressor CtBP.	ctbp	212-216	APC regulator of WNT signaling pathway	Homo sapiens	177-180
18676825-7	2008	Enhancing CtBP-mediated repression by growing cells in low oxygen increased the association of CtBP with the p16 promoter, as assessed by chromatin immunoprecipitation, and reduced p16 expression.	ctbp	10-14	cyclin dependent kinase inhibitor 2A	Homo sapiens	109-112
18676825-7	2008	Enhancing CtBP-mediated repression by growing cells in low oxygen increased the association of CtBP with the p16 promoter, as assessed by chromatin immunoprecipitation, and reduced p16 expression.	ctbp	10-14	cyclin dependent kinase inhibitor 2A	Homo sapiens	181-184
18676825-7	2008	Enhancing CtBP-mediated repression by growing cells in low oxygen increased the association of CtBP with the p16 promoter, as assessed by chromatin immunoprecipitation, and reduced p16 expression.	ctbp	95-99	cyclin dependent kinase inhibitor 2A	Homo sapiens	109-112
18676825-8	2008	Stresses and stimuli that reduce CtBP-mediated repression are associated with increased p16 expression; therefore, CtBP may provide a common final target for regulating the balance among tumor suppression, regenerative capacity, and senescence.	ctbp	33-37	cyclin dependent kinase inhibitor 2A	Homo sapiens	88-91
18676825-8	2008	Stresses and stimuli that reduce CtBP-mediated repression are associated with increased p16 expression; therefore, CtBP may provide a common final target for regulating the balance among tumor suppression, regenerative capacity, and senescence.	ctbp	115-119	cyclin dependent kinase inhibitor 2A	Homo sapiens	88-91
18086895-1	2008	CtBP is a transcriptional corepressor with tumorigenic potential that targets the promoter of the tumor suppressor gene E-cadherin.	ctbp	0-4	cadherin 1	Homo sapiens	120-130
18483224-6	2008	In turn, recruitment of PPAR-gamma-coactivator-1alpha (PGC-1alpha) and PGC-1beta to the PRDM16 complex displaces CtBP, allowing this complex to powerfully activate brown fat genes, such as PGC-1alpha itself.	ctbp	113-117	PPARG coactivator 1 alpha	Homo sapiens	24-53
18483224-6	2008	In turn, recruitment of PPAR-gamma-coactivator-1alpha (PGC-1alpha) and PGC-1beta to the PRDM16 complex displaces CtBP, allowing this complex to powerfully activate brown fat genes, such as PGC-1alpha itself.	ctbp	113-117	PPARG coactivator 1 alpha	Homo sapiens	55-65
18483224-6	2008	In turn, recruitment of PPAR-gamma-coactivator-1alpha (PGC-1alpha) and PGC-1beta to the PRDM16 complex displaces CtBP, allowing this complex to powerfully activate brown fat genes, such as PGC-1alpha itself.	ctbp	113-117	PPARG coactivator 1 beta	Homo sapiens	71-80
18483224-6	2008	In turn, recruitment of PPAR-gamma-coactivator-1alpha (PGC-1alpha) and PGC-1beta to the PRDM16 complex displaces CtBP, allowing this complex to powerfully activate brown fat genes, such as PGC-1alpha itself.	ctbp	113-117	PR/SET domain 16	Homo sapiens	88-94
18483224-6	2008	In turn, recruitment of PPAR-gamma-coactivator-1alpha (PGC-1alpha) and PGC-1beta to the PRDM16 complex displaces CtBP, allowing this complex to powerfully activate brown fat genes, such as PGC-1alpha itself.	ctbp	113-117	PPARG coactivator 1 alpha	Homo sapiens	189-199
18086895-2	2008	Pnn/DRS (Pnn) is a "nuclear speckle"-associated protein involved in mRNA processing as well as transcriptional regulation of E-cadherin via its binding to CtBP.	ctbp	155-159	pinin, desmosome associated protein	Homo sapiens	0-3
18086895-2	2008	Pnn/DRS (Pnn) is a "nuclear speckle"-associated protein involved in mRNA processing as well as transcriptional regulation of E-cadherin via its binding to CtBP.	ctbp	155-159	pinin, desmosome associated protein	Homo sapiens	4-7
18086895-2	2008	Pnn/DRS (Pnn) is a "nuclear speckle"-associated protein involved in mRNA processing as well as transcriptional regulation of E-cadherin via its binding to CtBP.	ctbp	155-159	pinin, desmosome associated protein	Homo sapiens	9-12
18086895-2	2008	Pnn/DRS (Pnn) is a "nuclear speckle"-associated protein involved in mRNA processing as well as transcriptional regulation of E-cadherin via its binding to CtBP.	ctbp	155-159	cadherin 1	Homo sapiens	125-135
18086895-3	2008	Here, we show that CtBP can recruit Pnn to CtBP-associated complexes, resulting in Pnn-dependent chromatin remodeling at the E-cadherin promoter.	ctbp	19-23	pinin, desmosome associated protein	Homo sapiens	36-39
18086895-3	2008	Here, we show that CtBP can recruit Pnn to CtBP-associated complexes, resulting in Pnn-dependent chromatin remodeling at the E-cadherin promoter.	ctbp	19-23	pinin, desmosome associated protein	Homo sapiens	83-86
18086895-3	2008	Here, we show that CtBP can recruit Pnn to CtBP-associated complexes, resulting in Pnn-dependent chromatin remodeling at the E-cadherin promoter.	ctbp	19-23	cadherin 1	Homo sapiens	125-135
18086895-3	2008	Here, we show that CtBP can recruit Pnn to CtBP-associated complexes, resulting in Pnn-dependent chromatin remodeling at the E-cadherin promoter.	ctbp	43-47	pinin, desmosome associated protein	Homo sapiens	36-39
18086895-3	2008	Here, we show that CtBP can recruit Pnn to CtBP-associated complexes, resulting in Pnn-dependent chromatin remodeling at the E-cadherin promoter.	ctbp	43-47	pinin, desmosome associated protein	Homo sapiens	83-86
18086895-3	2008	Here, we show that CtBP can recruit Pnn to CtBP-associated complexes, resulting in Pnn-dependent chromatin remodeling at the E-cadherin promoter.	ctbp	43-47	cadherin 1	Homo sapiens	125-135
17213307-4	2007	Treatment with the glycolytic blocker 2-deoxyglucose (2-DG) decreases association of the redox sensor CtBP with HIC1, an inhibitor of SIRT1 transcription.	ctbp	102-106	HIC ZBTB transcriptional repressor 1	Homo sapiens	112-116
18093972-1	2008	Homeodomain-interacting protein kinase 2 (HIPK2) is a member of the nuclear protein kinase family, which induces both p53- and CtBP-mediated apoptosis.	ctbp	127-131	homeodomain interacting protein kinase 2	Homo sapiens	0-40
18093972-1	2008	Homeodomain-interacting protein kinase 2 (HIPK2) is a member of the nuclear protein kinase family, which induces both p53- and CtBP-mediated apoptosis.	ctbp	127-131	homeodomain interacting protein kinase 2	Homo sapiens	42-47
17379597-0	2007	A novel corepressor, BCoR-L1, represses transcription through an interaction with CtBP.	ctbp	82-86	BCL6 corepressor like 1	Homo sapiens	21-28
17379597-7	2007	BCoR-L1 also interacts with the CtBP corepressor through a CtBP-interacting motif in its amino terminus.	ctbp	32-36	BCL6 corepressor like 1	Homo sapiens	0-7
17379597-7	2007	BCoR-L1 also interacts with the CtBP corepressor through a CtBP-interacting motif in its amino terminus.	ctbp	59-63	BCL6 corepressor like 1	Homo sapiens	0-7
17379597-8	2007	Abrogation of the CtBP binding site within BCoR-L1 partially relieves BCoR-L1-mediated transcriptional repression.	ctbp	18-22	BCL6 corepressor like 1	Homo sapiens	43-50
17379597-8	2007	Abrogation of the CtBP binding site within BCoR-L1 partially relieves BCoR-L1-mediated transcriptional repression.	ctbp	18-22	BCL6 corepressor like 1	Homo sapiens	70-77
17379597-10	2007	The inhibition of BCoR-L1 expression by RNA-mediated interference results in derepression of E-cadherin in cells that do not normally express E-cadherin, indicating that BCoR-L1 contributes to the repression of an authentic endogenous CtBP target.	ctbp	235-239	BCL6 corepressor like 1	Homo sapiens	18-25
17379597-10	2007	The inhibition of BCoR-L1 expression by RNA-mediated interference results in derepression of E-cadherin in cells that do not normally express E-cadherin, indicating that BCoR-L1 contributes to the repression of an authentic endogenous CtBP target.	ctbp	235-239	cadherin 1	Homo sapiens	93-103
17379597-10	2007	The inhibition of BCoR-L1 expression by RNA-mediated interference results in derepression of E-cadherin in cells that do not normally express E-cadherin, indicating that BCoR-L1 contributes to the repression of an authentic endogenous CtBP target.	ctbp	235-239	BCL6 corepressor like 1	Homo sapiens	170-177
17213307-4	2007	Treatment with the glycolytic blocker 2-deoxyglucose (2-DG) decreases association of the redox sensor CtBP with HIC1, an inhibitor of SIRT1 transcription.	ctbp	102-106	sirtuin 1	Homo sapiens	134-139
17213307-5	2007	We propose that the reduction in transcriptional repression mediated by HIC1, due to the decrease of CtBP binding, increases SIRT1 expression.	ctbp	101-105	HIC ZBTB transcriptional repressor 1	Homo sapiens	72-76
17213307-5	2007	We propose that the reduction in transcriptional repression mediated by HIC1, due to the decrease of CtBP binding, increases SIRT1 expression.	ctbp	101-105	sirtuin 1	Homo sapiens	125-130
16547505-0	2006	TCF-4 isoforms absent in TCF-4 mutated MSI-H colorectal cancer cells colocalize with nuclear CtBP and repress TCF-4-mediated transcription.	ctbp	93-97	transcription factor 4	Homo sapiens	25-30
16804902-9	2006	However, when CtBP was strongly expressed, ZEB1 was inversely correlated with CDH1 (r = -0.39; p = 0.053).	ctbp	14-18	zinc finger E-box binding homeobox 1	Homo sapiens	43-47
16804902-9	2006	However, when CtBP was strongly expressed, ZEB1 was inversely correlated with CDH1 (r = -0.39; p = 0.053).	ctbp	14-18	cadherin 1	Homo sapiens	78-82
16804902-12	2006	These results indicate that the levels of expression of CtBP and p300 are critical for the action of SNAIL and ZEB1, which have a pivotal role in EMT, and show the importance of CtBP and p300 for tumor progression.	ctbp	56-60	snail family transcriptional repressor 1	Homo sapiens	101-106
16804902-12	2006	These results indicate that the levels of expression of CtBP and p300 are critical for the action of SNAIL and ZEB1, which have a pivotal role in EMT, and show the importance of CtBP and p300 for tumor progression.	ctbp	56-60	zinc finger E-box binding homeobox 1	Homo sapiens	111-115
16804902-12	2006	These results indicate that the levels of expression of CtBP and p300 are critical for the action of SNAIL and ZEB1, which have a pivotal role in EMT, and show the importance of CtBP and p300 for tumor progression.	ctbp	56-60	E1A binding protein p300	Homo sapiens	187-191
17041593-0	2006	2-Deoxy-D-glucose reduces epilepsy progression by NRSF-CtBP-dependent metabolic regulation of chromatin structure.	ctbp	55-59	RE1-silencing transcription factor	Rattus norvegicus	50-54
17041593-4	2006	This reduced expression is mediated by the transcription factor NRSF, which recruits the NADH-binding co-repressor CtBP to generate a repressive chromatin environment around the BDNF promoter.	ctbp	115-119	RE1-silencing transcription factor	Rattus norvegicus	64-68
17041593-4	2006	This reduced expression is mediated by the transcription factor NRSF, which recruits the NADH-binding co-repressor CtBP to generate a repressive chromatin environment around the BDNF promoter.	ctbp	115-119	brain-derived neurotrophic factor	Rattus norvegicus	178-182
16547505-0	2006	TCF-4 isoforms absent in TCF-4 mutated MSI-H colorectal cancer cells colocalize with nuclear CtBP and repress TCF-4-mediated transcription.	ctbp	93-97	transcription factor 4	Homo sapiens	0-5
16547505-0	2006	TCF-4 isoforms absent in TCF-4 mutated MSI-H colorectal cancer cells colocalize with nuclear CtBP and repress TCF-4-mediated transcription.	ctbp	93-97	transcription factor 4	Homo sapiens	25-30
16547505-4	2006	Of interest, we described a frequent TCF-4 frameshift mutation in mismatch-repair deficient colorectal cancers (MSI-H cancers) that leads to the selective loss of TCF-4 isoforms with CtBP binding abilities.	ctbp	183-187	transcription factor 4	Homo sapiens	37-42
16547505-4	2006	Of interest, we described a frequent TCF-4 frameshift mutation in mismatch-repair deficient colorectal cancers (MSI-H cancers) that leads to the selective loss of TCF-4 isoforms with CtBP binding abilities.	ctbp	183-187	transcription factor 4	Homo sapiens	163-168
16547505-5	2006	We provide here data that argue for a partial colocalization of CtBP with TCF-4 isoforms containing CtBP binding domains in cellulo, and for a functional role of CtBP in repressing TCF-4 mediated transcription.	ctbp	64-68	transcription factor 4	Homo sapiens	74-79
16547505-5	2006	We provide here data that argue for a partial colocalization of CtBP with TCF-4 isoforms containing CtBP binding domains in cellulo, and for a functional role of CtBP in repressing TCF-4 mediated transcription.	ctbp	100-104	transcription factor 4	Homo sapiens	74-79
16547505-5	2006	We provide here data that argue for a partial colocalization of CtBP with TCF-4 isoforms containing CtBP binding domains in cellulo, and for a functional role of CtBP in repressing TCF-4 mediated transcription.	ctbp	100-104	transcription factor 4	Homo sapiens	74-79
16547505-7	2006	Taken together, our results strongly suggest that CtBP would play a role in regulating TCF-4 mediated transcription upon its binding with some TCF-4 isoforms encoded by alternatively spliced mRNA.	ctbp	50-54	transcription factor 4	Homo sapiens	87-92
16547505-7	2006	Taken together, our results strongly suggest that CtBP would play a role in regulating TCF-4 mediated transcription upon its binding with some TCF-4 isoforms encoded by alternatively spliced mRNA.	ctbp	50-54	transcription factor 4	Homo sapiens	143-148
16574097-10	2006	Together, these data indicate that Evi1 plays a role in the proximo-distal patterning of the pronephros and suggest that it may do so by functioning as a CtBP dependent repressor.	ctbp	154-158	MDS1 and EVI1 complex locus	Xenopus laevis	35-39
16740659-2	2006	In this study, we found that hypoxia increased free NADH levels in cancer cells, promoting CtBP recruitment to the E-cadherin promoter.	ctbp	91-95	cadherin 1	Homo sapiens	115-125
16740659-4	2006	Furthermore, hypoxia repressed E-cadherin gene expression and increased tumor cell migration, effects that were blocked by CtBP knockdown.	ctbp	123-127	cadherin 1	Homo sapiens	31-41
16510874-6	2006	Interestingly, APC-mediated repression of c-Myc transcription in HT29-APC colorectal cancer cells is initiated by the transient binding of APC, betaTrCP, and the CtBP corepressor to the c-Myc enhancer, followed by stable binding of the TLE-1 and HDAC1 corepressors.	ctbp	162-166	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	42-47
16510874-6	2006	Interestingly, APC-mediated repression of c-Myc transcription in HT29-APC colorectal cancer cells is initiated by the transient binding of APC, betaTrCP, and the CtBP corepressor to the c-Myc enhancer, followed by stable binding of the TLE-1 and HDAC1 corepressors.	ctbp	162-166	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	186-191
16510874-6	2006	Interestingly, APC-mediated repression of c-Myc transcription in HT29-APC colorectal cancer cells is initiated by the transient binding of APC, betaTrCP, and the CtBP corepressor to the c-Myc enhancer, followed by stable binding of the TLE-1 and HDAC1 corepressors.	ctbp	162-166	TLE family member 1, transcriptional corepressor	Homo sapiens	236-241
16510874-6	2006	Interestingly, APC-mediated repression of c-Myc transcription in HT29-APC colorectal cancer cells is initiated by the transient binding of APC, betaTrCP, and the CtBP corepressor to the c-Myc enhancer, followed by stable binding of the TLE-1 and HDAC1 corepressors.	ctbp	162-166	histone deacetylase 1	Homo sapiens	246-251
16319893-5	2005	Likewise, the LPAAT activity associated with CtBP/BARS is also a co-purification artefact.	ctbp	45-49	membrane bound O-acyltransferase domain containing 2	Homo sapiens	14-19
17085477-4	2006	Further, we show that ZNF366 acts as a corepressor by interacting with other known ERalpha corepressors, namely RIP140 and CtBP, to inhibit expression of estrogen-responsive genes in vivo.	ctbp	123-127	zinc finger protein 366	Homo sapiens	22-28
17085477-4	2006	Further, we show that ZNF366 acts as a corepressor by interacting with other known ERalpha corepressors, namely RIP140 and CtBP, to inhibit expression of estrogen-responsive genes in vivo.	ctbp	123-127	estrogen receptor 1	Homo sapiens	83-90
16287852-6	2005	We identify the CtIP and CtBP corepressors as novel components of the human RBP-Jkappa/SHARP-corepressor complex and show that CtIP binds directly to the SHARP repression domain.	ctbp	25-29	recombination signal binding protein for immunoglobulin kappa J region	Homo sapiens	76-86
16287852-6	2005	We identify the CtIP and CtBP corepressors as novel components of the human RBP-Jkappa/SHARP-corepressor complex and show that CtIP binds directly to the SHARP repression domain.	ctbp	25-29	spen family transcriptional repressor	Homo sapiens	87-92
16287852-7	2005	Functionally, CtIP and CtBP augment SHARP-mediated repression.	ctbp	23-27	spen family transcriptional repressor	Homo sapiens	36-41
16287852-10	2005	We propose that a corepressor complex containing CtIP/CtBP facilitates RBP-Jkappa/SHARP-mediated repression of Notch target genes.	ctbp	54-58	RB binding protein 8, endonuclease	Homo sapiens	49-53
16287852-10	2005	We propose that a corepressor complex containing CtIP/CtBP facilitates RBP-Jkappa/SHARP-mediated repression of Notch target genes.	ctbp	54-58	recombination signal binding protein for immunoglobulin kappa J region	Homo sapiens	71-81
16287852-10	2005	We propose that a corepressor complex containing CtIP/CtBP facilitates RBP-Jkappa/SHARP-mediated repression of Notch target genes.	ctbp	54-58	spen family transcriptional repressor	Homo sapiens	82-87
16319893-5	2005	Likewise, the LPAAT activity associated with CtBP/BARS is also a co-purification artefact.	ctbp	45-49	C-terminal binding protein 1	Homo sapiens	50-54
16254191-4	2005	We now find that CtBP can interact with the histone acetyltransferase, cyclic AMP--responsive element--binding protein (CREB) binding protein, and inhibit its ability to acetylate histone.	ctbp	17-21	cAMP responsive element binding protein 1	Homo sapiens	71-118
16254191-4	2005	We now find that CtBP can interact with the histone acetyltransferase, cyclic AMP--responsive element--binding protein (CREB) binding protein, and inhibit its ability to acetylate histone.	ctbp	17-21	cAMP responsive element binding protein 1	Homo sapiens	120-124
16036112-0	2005	The hTERT and hTERC telomerase gene promoters are activated by the second exon of the adenoviral protein, E1A, identifying the transcriptional corepressor CtBP as a potential repressor of both genes.	ctbp	155-159	telomerase reverse transcriptase	Homo sapiens	4-9
15897867-0	2005	Oligomerization of Evi-1 regulated by the PR domain contributes to recruitment of corepressor CtBP.	ctbp	94-98	RUNX family transcription factor 1	Homo sapiens	19-24
15958389-2	2005	Previous reports showed that HIPK2 can signal cell death via p53, and independently of p53 by activating the c-Jun NH2-terminal kinase (JNK) pathway or mediating CtBP degradation.	ctbp	162-166	homeodomain interacting protein kinase 2	Homo sapiens	29-34
16036112-0	2005	The hTERT and hTERC telomerase gene promoters are activated by the second exon of the adenoviral protein, E1A, identifying the transcriptional corepressor CtBP as a potential repressor of both genes.	ctbp	155-159	telomerase RNA component	Homo sapiens	14-19
15728189-8	2005	CC3 provides an example of the adaptation of a metabolic enzyme fold to include a regulatory role, as also seen in the case of the NADH-binding co-repressor CtBP.	ctbp	157-161	HIV-1 Tat interactive protein 2	Homo sapiens	0-3
12556451-2	2003	BKLF/KLF3, a member of the Kruppel-like factor family of zinc finger proteins, is a potent transcriptional repressor that recruits a CtBP co-repressor.	ctbp	133-137	Kruppel like factor 3	Homo sapiens	0-4
15708980-0	2005	Homeodomain-interacting protein kinase-2 mediates CtBP phosphorylation and degradation in UV-triggered apoptosis.	ctbp	50-54	homeodomain interacting protein kinase 2	Homo sapiens	0-40
15708980-4	2005	HIPK2 phosphorylates CtBP at Ser-422 in vitro.	ctbp	21-25	homeodomain interacting protein kinase 2	Homo sapiens	0-5
15708980-8	2005	Interference with HIPK2 function via the kinase-dead mutant decreased CtBP ubiquitination.	ctbp	70-74	homeodomain interacting protein kinase 2	Homo sapiens	18-23
15542832-0	2004	Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene.	ctbp	84-88	pinin, desmosome associated protein	Homo sapiens	35-38
15542832-0	2004	Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene.	ctbp	84-88	pinin, desmosome associated protein	Homo sapiens	39-42
15542832-0	2004	Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene.	ctbp	102-106	pinin, desmosome associated protein	Homo sapiens	35-38
15542832-0	2004	Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene.	ctbp	102-106	pinin, desmosome associated protein	Homo sapiens	39-42
15542832-0	2004	Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene.	ctbp	102-106	cadherin 1	Homo sapiens	134-144
15156182-7	2004	Although target genes repressed by AML1/EVI-1 are still not known, binding competition to a specific DNA sequence and histone deacetylase recruitment through a co-repressor CtBP in EVI-1 part are conceivable underlying mechanisms for the dominant-negative effects.	ctbp	173-177	RUNX family transcription factor 1	Homo sapiens	35-39
15156182-7	2004	Although target genes repressed by AML1/EVI-1 are still not known, binding competition to a specific DNA sequence and histone deacetylase recruitment through a co-repressor CtBP in EVI-1 part are conceivable underlying mechanisms for the dominant-negative effects.	ctbp	173-177	RUNX family transcription factor 1	Homo sapiens	40-45
15156182-7	2004	Although target genes repressed by AML1/EVI-1 are still not known, binding competition to a specific DNA sequence and histone deacetylase recruitment through a co-repressor CtBP in EVI-1 part are conceivable underlying mechanisms for the dominant-negative effects.	ctbp	173-177	RUNX family transcription factor 1	Homo sapiens	181-186
15156182-9	2004	The first zinc-finger domain of EVI-1 associates with Smad3, a TGF beta signal transducer, and represses its transcriptional activity by recruiting histone deacetylase through CtBP that interacts with EVI-1.	ctbp	176-180	RUNX family transcription factor 1	Homo sapiens	32-37
15156182-9	2004	The first zinc-finger domain of EVI-1 associates with Smad3, a TGF beta signal transducer, and represses its transcriptional activity by recruiting histone deacetylase through CtBP that interacts with EVI-1.	ctbp	176-180	SMAD family member 3	Homo sapiens	54-59
15156182-9	2004	The first zinc-finger domain of EVI-1 associates with Smad3, a TGF beta signal transducer, and represses its transcriptional activity by recruiting histone deacetylase through CtBP that interacts with EVI-1.	ctbp	176-180	transforming growth factor beta 1	Homo sapiens	63-71
15156182-9	2004	The first zinc-finger domain of EVI-1 associates with Smad3, a TGF beta signal transducer, and represses its transcriptional activity by recruiting histone deacetylase through CtBP that interacts with EVI-1.	ctbp	176-180	RUNX family transcription factor 1	Homo sapiens	201-206
15110709-10	2004	This unique property of Snail in mesoderm formation can be attributed mostly to the CtBP co-repressor interaction motifs in the N-terminus, not to the C-terminal DNA-binding zinc fingers.	ctbp	84-88	snail	Drosophila melanogaster	24-29
15037661-5	2004	Here we extend the functional characterization of CtBP by demonstrating that amino acid substitutions at Gly189 in the conserved NAD+-binding fold both abrogate the ability of CtBP2 to homodimerize and are associated with a dramatic loss of co-repressor activity.	ctbp	50-54	C-terminal binding protein 2	Homo sapiens	176-181
15592428-2	2005	Here we demonstrate that, in vivo, Pc2 adapter function contributes to enhancement of CtBP sumoylation.	ctbp	86-90	chromobox 4	Homo sapiens	35-38
15592428-3	2005	Mutation of the CtBP binding site on Pc2 abolishes E3 activity toward CtBP.	ctbp	16-20	chromobox 4	Homo sapiens	37-40
15592428-3	2005	Mutation of the CtBP binding site on Pc2 abolishes E3 activity toward CtBP.	ctbp	70-74	chromobox 4	Homo sapiens	37-40
15592428-4	2005	However, a carboxyl-terminal fragment of Pc2 that recruits both Ubc9 and CtBP lacks E3 activity.	ctbp	73-77	chromobox 4	Homo sapiens	41-44
15520279-0	2004	YY1 DNA binding and PcG recruitment requires CtBP.	ctbp	45-49	YY1 transcription factor	Homo sapiens	0-3
15520279-0	2004	YY1 DNA binding and PcG recruitment requires CtBP.	ctbp	45-49	Polycomb	Drosophila melanogaster	20-23
15520279-3	2004	In a CtBP mutant background, recruitment of PcG proteins and concomitant histone modifications do not occur.	ctbp	5-9	Polycomb	Drosophila melanogaster	44-47
15520279-6	2004	These results reveal a new role for CtBP in controlling YY1 DNA binding and recruitment of PcG proteins to DNA.	ctbp	36-40	YY1 transcription factor	Homo sapiens	56-59
15520279-6	2004	These results reveal a new role for CtBP in controlling YY1 DNA binding and recruitment of PcG proteins to DNA.	ctbp	36-40	Polycomb	Drosophila melanogaster	91-94
15485915-2	2004	We demonstrate here that a CTBP-interacting protein CtIP interacts with BRCA1 BRCT domains in a phosphorylation-dependent manner.	ctbp	27-31	RB binding protein 8, endonuclease	Homo sapiens	52-56
15485915-2	2004	We demonstrate here that a CTBP-interacting protein CtIP interacts with BRCA1 BRCT domains in a phosphorylation-dependent manner.	ctbp	27-31	BRCA1 DNA repair associated	Homo sapiens	72-77
12805226-3	2003	Here, we report the crystal structures of rat CtBP/BARS in a binary complex with NAD(H), and in a ternary complex with a PIDLSKK peptide mimicking the consensus motif (PXDLS) recognized in CtBP/BARS cellular partners.	ctbp	46-50	C-terminal binding protein 1	Rattus norvegicus	51-55
12805226-3	2003	Here, we report the crystal structures of rat CtBP/BARS in a binary complex with NAD(H), and in a ternary complex with a PIDLSKK peptide mimicking the consensus motif (PXDLS) recognized in CtBP/BARS cellular partners.	ctbp	46-50	C-terminal binding protein 1	Rattus norvegicus	194-198
12805226-3	2003	Here, we report the crystal structures of rat CtBP/BARS in a binary complex with NAD(H), and in a ternary complex with a PIDLSKK peptide mimicking the consensus motif (PXDLS) recognized in CtBP/BARS cellular partners.	ctbp	189-193	C-terminal binding protein 1	Rattus norvegicus	51-55
12805226-4	2003	The structural data show CtBP/BARS in a NAD(H)-bound dimeric form; the peptide binding maps the recognition site for DNA-binding proteins and histone deacetylases to an N-terminal region of the protein.	ctbp	25-29	C-terminal binding protein 1	Rattus norvegicus	30-34
12805226-5	2003	The crystal structure together with the site-directed mutagenesis data and binding experiments suggest a rationale for the molecular mechanisms underlying the two fundamental co-existing, but diverse, activities supported by CtBP/BARS in the nucleus and in Golgi membranes.	ctbp	225-229	C-terminal binding protein 1	Rattus norvegicus	230-234
12556451-2	2003	BKLF/KLF3, a member of the Kruppel-like factor family of zinc finger proteins, is a potent transcriptional repressor that recruits a CtBP co-repressor.	ctbp	133-137	Kruppel like factor 3	Homo sapiens	5-9
12679040-2	2003	The human PcG protein, Pc2, has been shown to recruit the transcriptional corepressor, CtBP, to PcG bodies.	ctbp	87-91	chromobox 4	Homo sapiens	23-26
12679040-4	2003	In vitro, CtBP sumoylation minimally requires the SUMO E1 and E2 (Ubc9) and SUMO-1.	ctbp	10-14	ubiquitin conjugating enzyme E2 I	Homo sapiens	66-70
12679040-4	2003	In vitro, CtBP sumoylation minimally requires the SUMO E1 and E2 (Ubc9) and SUMO-1.	ctbp	10-14	small ubiquitin like modifier 1	Homo sapiens	76-82
12679040-5	2003	However, Pc2 dramatically enhances CtBP sumoylation.	ctbp	35-39	chromobox 4	Homo sapiens	9-12
12679040-6	2003	In vivo, this is likely due to the ability of Pc2 to recruit both CtBP and Ubc9 to PcG bodies, thereby bringing together substrate and E2, and stimulating the transfer of SUMO to CtBP.	ctbp	66-70	chromobox 4	Homo sapiens	46-49
12679040-6	2003	In vivo, this is likely due to the ability of Pc2 to recruit both CtBP and Ubc9 to PcG bodies, thereby bringing together substrate and E2, and stimulating the transfer of SUMO to CtBP.	ctbp	179-183	chromobox 4	Homo sapiens	46-49
12052894-0	2002	The human candidate tumor suppressor gene HIC1 recruits CtBP through a degenerate GLDLSKK motif.	ctbp	56-60	HIC ZBTB transcriptional repressor 1	Homo sapiens	42-46
12621550-4	2003	By observing their subcellular localization, it was found that the three zinc fingers of hBKLF and the N-terminal aside from the fingers all served as nuclear localization signals (NLS); the sub-NLS of hBKLF was located in the N-terminus, including the CtBP-binding motif and the proline rich domain.	ctbp	253-257	Kruppel like factor 3	Homo sapiens	202-207
12015313-2	2002	Repression is mediated through two independent domains at the N and C terminus of the protein, both of which can independently recruit the corepressors Mi-2beta, Sin3A, and Sin3B and the Class I histone deacetylases 1 and 2; the N-terminal domain can also associate with the corepressor CtBP.	ctbp	287-291	chromodomain helicase DNA binding protein 4	Homo sapiens	152-160
12015313-2	2002	Repression is mediated through two independent domains at the N and C terminus of the protein, both of which can independently recruit the corepressors Mi-2beta, Sin3A, and Sin3B and the Class I histone deacetylases 1 and 2; the N-terminal domain can also associate with the corepressor CtBP.	ctbp	287-291	SIN3 transcription regulator family member A	Homo sapiens	162-167
12015313-2	2002	Repression is mediated through two independent domains at the N and C terminus of the protein, both of which can independently recruit the corepressors Mi-2beta, Sin3A, and Sin3B and the Class I histone deacetylases 1 and 2; the N-terminal domain can also associate with the corepressor CtBP.	ctbp	287-291	SIN3 transcription regulator family member B	Homo sapiens	173-178
12015313-5	2002	Finally, we show that, barring CtBP, the Ikaros family members Aiolos, Helios, and Eos can associate with all of the identified corepressors of Ikaros including its newly identified interactors, Class II HDACs.	ctbp	31-35	IKAROS family zinc finger 1	Homo sapiens	41-47
12015313-5	2002	Finally, we show that, barring CtBP, the Ikaros family members Aiolos, Helios, and Eos can associate with all of the identified corepressors of Ikaros including its newly identified interactors, Class II HDACs.	ctbp	31-35	IKAROS family zinc finger 1	Homo sapiens	144-150
12052894-2	2002	Alignment of the HIC1 and HRG22 proteins from various species highlighted a perfectly conserved GLDLSKK/R motif highly related to the consensus CtBP interaction motif (PXDLSXK/R), except for the replacement of the virtually invariant proline by a glycine.	ctbp	144-148	HIC ZBTB transcriptional repressor 1	Homo sapiens	17-21
12052894-2	2002	Alignment of the HIC1 and HRG22 proteins from various species highlighted a perfectly conserved GLDLSKK/R motif highly related to the consensus CtBP interaction motif (PXDLSXK/R), except for the replacement of the virtually invariant proline by a glycine.	ctbp	144-148	HIC ZBTB transcriptional repressor 2	Homo sapiens	26-31
12052894-3	2002	HIC1 strongly interacts with mCtBP1 both in vivo and in vitro through this conserved GLDLSKK motif, thus extending the CtBP consensus binding site.	ctbp	30-34	HIC ZBTB transcriptional repressor 1	Homo sapiens	0-4
12052894-5	2002	When tethered to DNA by fusion with the Gal4 DNA-binding domain, the HIC1 central region represses transcription through interactions with CtBP in a trichostatin A-sensitive manner.	ctbp	139-143	galectin 4	Homo sapiens	40-44
12052894-5	2002	When tethered to DNA by fusion with the Gal4 DNA-binding domain, the HIC1 central region represses transcription through interactions with CtBP in a trichostatin A-sensitive manner.	ctbp	139-143	HIC ZBTB transcriptional repressor 1	Homo sapiens	69-73
12052894-6	2002	In conclusion, our results demonstrate that HIC1 mediates transcriptional repression by both HDAC-independent and HDAC-dependent mechanisms and show that CtBP is a HIC1 corepressor that is recruited via a variant binding site.	ctbp	154-158	HIC ZBTB transcriptional repressor 1	Homo sapiens	44-48
12052894-6	2002	In conclusion, our results demonstrate that HIC1 mediates transcriptional repression by both HDAC-independent and HDAC-dependent mechanisms and show that CtBP is a HIC1 corepressor that is recruited via a variant binding site.	ctbp	154-158	HIC ZBTB transcriptional repressor 1	Homo sapiens	164-168
11022042-5	2001	We show that the amino-terminal regions of MITR and class II HDACs interact with the transcriptional corepressor, COOH-terminal-binding protein (CtBP), through a CtBP-binding motif (P-X-D-L-R) conserved in MITR and HDACs 4, 5, and 7.	ctbp	145-149	histone deacetylase 9	Homo sapiens	43-47
11509661-0	2001	Acetylation of nuclear hormone receptor-interacting protein RIP140 regulates binding of the transcriptional corepressor CtBP.	ctbp	120-124	nuclear receptor interacting protein 1	Homo sapiens	60-66
11509661-3	2001	We previously showed that the CtBP-binding motif in E1A is flanked by a Lys residue and suggested that acetylation of this residue by the p300/CBP-associated factor P/CAF disrupts the CtBP interaction.	ctbp	30-34	lysine acetyltransferase 2B	Homo sapiens	138-170
11509661-3	2001	We previously showed that the CtBP-binding motif in E1A is flanked by a Lys residue and suggested that acetylation of this residue by the p300/CBP-associated factor P/CAF disrupts the CtBP interaction.	ctbp	184-188	lysine acetyltransferase 2B	Homo sapiens	138-170
11509661-4	2001	In this study, we show that the interaction between CtBP and the nuclear hormone receptor corepressor RIP140 is regulated similarly, in this case by p300/CBP itself.	ctbp	52-56	nuclear receptor interacting protein 1	Homo sapiens	102-108
11509661-4	2001	In this study, we show that the interaction between CtBP and the nuclear hormone receptor corepressor RIP140 is regulated similarly, in this case by p300/CBP itself.	ctbp	52-56	E1A binding protein p300	Homo sapiens	149-153
11509661-4	2001	In this study, we show that the interaction between CtBP and the nuclear hormone receptor corepressor RIP140 is regulated similarly, in this case by p300/CBP itself.	ctbp	52-56	CREB binding protein	Homo sapiens	154-157
11509661-5	2001	CtBP was shown to interact with RIP140 in vitro and in vivo through a sequence, PIDLSCK, in the amino-terminal third of the RIP140 protein.	ctbp	0-4	nuclear receptor interacting protein 1	Homo sapiens	32-38
11509661-5	2001	CtBP was shown to interact with RIP140 in vitro and in vivo through a sequence, PIDLSCK, in the amino-terminal third of the RIP140 protein.	ctbp	0-4	nuclear receptor interacting protein 1	Homo sapiens	124-130
11509661-6	2001	Acetylation of the Lys residue in this motif, demonstrated in vivo by using an acetylated RIP140-specific antibody, dramatically reduced CtBP binding.	ctbp	137-141	nuclear receptor interacting protein 1	Homo sapiens	90-96
11587364-7	2001	We also demonstrated that Evi-1 represses Smad-induced transcriptional activation by recruiting CtBP as a corepressor.	ctbp	96-100	MDS1 and EVI1 complex locus	Homo sapiens	26-31
11587364-8	2001	Evi-1 associates with CtBP1 through one of the CtBP-binding consensus motifs within the region from amino acid 544 to 607, and this association is required for the efficient inhibition of TGF-beta signaling.	ctbp	22-26	MDS1 and EVI1 complex locus	Homo sapiens	0-5
11587364-8	2001	Evi-1 associates with CtBP1 through one of the CtBP-binding consensus motifs within the region from amino acid 544 to 607, and this association is required for the efficient inhibition of TGF-beta signaling.	ctbp	22-26	transforming growth factor beta 1	Homo sapiens	188-196
11279209-6	2001	HDAC7 interacts with CtBP and other class-I and -II HDACs suggesting that silencing of MEF2 activity involves corepressor recruitment.	ctbp	21-25	histone deacetylase 7	Homo sapiens	0-5
11279209-6	2001	HDAC7 interacts with CtBP and other class-I and -II HDACs suggesting that silencing of MEF2 activity involves corepressor recruitment.	ctbp	21-25	myocyte enhancer factor 2A	Homo sapiens	87-91
11222711-4	2001	Tcf4 is constitutively activated by mutations in the adenomatous polyposis coli and beta-catenin genes in virtually all colon tumors and is constitutively repressed by Groucho and CtBP in normal tissue.	ctbp	180-184	transcription factor 4	Homo sapiens	0-4
11022042-5	2001	We show that the amino-terminal regions of MITR and class II HDACs interact with the transcriptional corepressor, COOH-terminal-binding protein (CtBP), through a CtBP-binding motif (P-X-D-L-R) conserved in MITR and HDACs 4, 5, and 7.	ctbp	145-149	histone deacetylase 9	Homo sapiens	206-210
11022042-5	2001	We show that the amino-terminal regions of MITR and class II HDACs interact with the transcriptional corepressor, COOH-terminal-binding protein (CtBP), through a CtBP-binding motif (P-X-D-L-R) conserved in MITR and HDACs 4, 5, and 7.	ctbp	162-166	histone deacetylase 9	Homo sapiens	43-47
11022042-5	2001	We show that the amino-terminal regions of MITR and class II HDACs interact with the transcriptional corepressor, COOH-terminal-binding protein (CtBP), through a CtBP-binding motif (P-X-D-L-R) conserved in MITR and HDACs 4, 5, and 7.	ctbp	162-166	histone deacetylase 9	Homo sapiens	206-210
11022042-6	2001	Mutation of this sequence in MITR abolishes interaction with CtBP and impairs, but does not eliminate, the ability of MITR to inhibit MEF2-dependent transcription.	ctbp	61-65	histone deacetylase 9	Homo sapiens	29-33
11022042-7	2001	The residual repressive activity of MITR mutants that fail to bind CtBP can be attributed to association with other HDAC family members.	ctbp	67-71	histone deacetylase 9	Homo sapiens	36-40
11022042-8	2001	These findings reveal CtBP-dependent and -independent mechanisms for transcriptional repression by MITR and show that MITR represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs.	ctbp	22-26	histone deacetylase 9	Homo sapiens	99-103
11022042-8	2001	These findings reveal CtBP-dependent and -independent mechanisms for transcriptional repression by MITR and show that MITR represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs.	ctbp	22-26	histone deacetylase 9	Homo sapiens	118-122
11022042-8	2001	These findings reveal CtBP-dependent and -independent mechanisms for transcriptional repression by MITR and show that MITR represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs.	ctbp	22-26	myocyte enhancer factor 2A	Homo sapiens	133-137
11022042-8	2001	These findings reveal CtBP-dependent and -independent mechanisms for transcriptional repression by MITR and show that MITR represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs.	ctbp	220-224	histone deacetylase 9	Homo sapiens	118-122
11022042-8	2001	These findings reveal CtBP-dependent and -independent mechanisms for transcriptional repression by MITR and show that MITR represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs.	ctbp	220-224	myocyte enhancer factor 2A	Homo sapiens	133-137