PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
22288884-0	2012	Biological activity of anti-CD20 multivalent HPMA copolymer-Fab" conjugates.	copolymer	50-59	keratin 20	Homo sapiens	28-32
22288884-0	2012	Biological activity of anti-CD20 multivalent HPMA copolymer-Fab" conjugates.	copolymer	50-59	FA complementation group B	Homo sapiens	60-63
22352958-2	2012	Despite having similar IECs, multiblock copolymer SPI and random copolymer SPI having sulfonate groups in the side chain exhibit higher ionic conductivity than random copolymer SPI having sulfonate groups in the main chain, indicating that the flexibility of sulfonic acid groups and the sequence distribution of ionic groups greatly affect the ion conduction.	copolymer	40-49	chromogranin A	Homo sapiens	50-53
22352958-2	2012	Despite having similar IECs, multiblock copolymer SPI and random copolymer SPI having sulfonate groups in the side chain exhibit higher ionic conductivity than random copolymer SPI having sulfonate groups in the main chain, indicating that the flexibility of sulfonic acid groups and the sequence distribution of ionic groups greatly affect the ion conduction.	copolymer	65-74	chromogranin A	Homo sapiens	75-78
22352958-2	2012	Despite having similar IECs, multiblock copolymer SPI and random copolymer SPI having sulfonate groups in the side chain exhibit higher ionic conductivity than random copolymer SPI having sulfonate groups in the main chain, indicating that the flexibility of sulfonic acid groups and the sequence distribution of ionic groups greatly affect the ion conduction.	copolymer	65-74	chromogranin A	Homo sapiens	75-78
22095295-0	2012	Controlled delivery of basal level of insulin from chitosan-zinc-insulin-complex-loaded thermosensitive copolymer.	copolymer	104-113	insulin	Homo sapiens	38-45
22095295-0	2012	Controlled delivery of basal level of insulin from chitosan-zinc-insulin-complex-loaded thermosensitive copolymer.	copolymer	104-113	insulin	Homo sapiens	65-72
22118775-0	2012	Anti-tumor activity of paclitaxel through dual-targeting carrier of cyclic RGD and transferrin conjugated hyperbranched copolymer nanoparticles.	copolymer	120-129	transferrin	Homo sapiens	83-94
22251101-1	2012	The deposition of amphiphilic poly(ethylene oxide)-block-poly(butadiene) (PEO-b-PBD) copolymer micelles is demonstrated on solid substrates.	copolymer	85-94	twinkle mtDNA helicase	Homo sapiens	74-77
22191486-0	2012	Block copolymer micelles target Auger electron radiotherapy to the nucleus of HER2-positive breast cancer cells.	copolymer	6-15	erb-b2 receptor tyrosine kinase 2	Homo sapiens	78-82
22257265-3	2012	70% of the core degraded within 48 h for block copolymer micelles of poly(N-(acryloyloxy)succinimide-copolymer-N-acryloylmorpholine)-block-poly(L-lactic acid) (P(NAS-co-NAM)-b-PLLA), with only a slight reduction to ca.	copolymer	47-56	SH3 and cysteine rich domain 3	Homo sapiens	169-172
22287556-4	2012	By varying the copolymer concentrations, we demonstrated that P24/PTMC11-F127-PTMC11 hydrogels were an efficient system for the sustained release of P24 over 21-35 days.	copolymer	15-24	transmembrane p24 trafficking protein 2	Homo sapiens	62-65
22287556-4	2012	By varying the copolymer concentrations, we demonstrated that P24/PTMC11-F127-PTMC11 hydrogels were an efficient system for the sustained release of P24 over 21-35 days.	copolymer	15-24	transmembrane p24 trafficking protein 2	Homo sapiens	149-152
22250203-6	2012	We demonstrate that adhesion of MSCs to the RGD-functionalized block-copolymer surfaces is through specific attachment to the presented RGD motif and that this is mediated by alpha5, alphaV, beta1 and beta3 integrins.	copolymer	69-78	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	191-206
22052706-3	2012	The silk/poly(L-lysine) block copolymer containing Lyp1 (ML-Lyp1) shows significant differences from silk/poly(L-lysine) block copolymer containing F3 (ML-F3) in cytotoxicity to MCF10A cells.	copolymer	30-39	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	51-55
22148329-6	2012	With immobilization of glucose oxidase (GOx) on the graft copolymer decorated electrode, a biosensor for glucose detection was prepared.	copolymer	58-67	hydroxyacid oxidase 1	Homo sapiens	23-38
22148329-6	2012	With immobilization of glucose oxidase (GOx) on the graft copolymer decorated electrode, a biosensor for glucose detection was prepared.	copolymer	58-67	hydroxyacid oxidase 1	Homo sapiens	40-43
22143909-5	2012	Copolymer/gelatine blends were microfabricated to obtain a ECM-like geometry.	copolymer	0-9	multimerin 1	Homo sapiens	59-62
22977303-4	2012	The corresponding well-defined vesicles with narrow size distribution were tailored by finely regulating the packing parameter (beta) of copolymer (1/2 < beta < 1).	copolymer	137-146	lymphotoxin beta	Homo sapiens	153-161
23028218-8	2012	The copolymer with NIPAAm/AAc/HEMAPCL ratio of 88:9.6:2.4 was bioconjugated with type I collagen for the purpose of biocompatibility enhancement.	copolymer	4-13	glycine-N-acyltransferase	Homo sapiens	26-29
22052706-3	2012	The silk/poly(L-lysine) block copolymer containing Lyp1 (ML-Lyp1) shows significant differences from silk/poly(L-lysine) block copolymer containing F3 (ML-F3) in cytotoxicity to MCF10A cells.	copolymer	30-39	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	57-64
21830140-0	2012	Extending residence time and stability of peptides by protected graft copolymer (PGC) excipient: GLP-1 example.	copolymer	70-79	glucagon	Rattus norvegicus	97-102
21981636-6	2011	A significant synergizing antitumor effect was seen when EL4 tumor-bearing mice were simultaneously exposed to EMF-BEMER and treated with suboptimal dose of synthetic HPMA copolymer-based doxorubicin, DOX(HYD)-HPMA.	copolymer	172-181	epilepsy 4	Mus musculus	57-60
27877462-3	2011	Measurements of electro-optical properties revealed that the addition of the SmA* LC not only strengthened the anchoring force of the copolymer alignment film surface, but also significantly enhanced the contrast ratio (~73%), response time and grayscale switching performance of the device.	copolymer	134-143	survival of motor neuron 1, telomeric	Homo sapiens	77-81
22074249-5	2011	GE11 copolymer conjugate binds specifically and efficiently to EGFR over-expressing cells, thus mediating internalisation to a significantly higher extent relative the copolymer conjugated to a scrambled sequence peptide.	copolymer	5-14	epidermal growth factor receptor	Homo sapiens	63-67
21932842-9	2011	To determine whether HC and normal fibrinogen could form a copolymer, we examined mixtures of these.	copolymer	59-68	fibrinogen beta chain	Homo sapiens	35-45
21820283-3	2011	The copolymer brush showed effective suppression of non-specific adsorption of bovine serum albumin and egg white lysozyme to the brush.	copolymer	4-13	albumin	Homo sapiens	86-99
21869819-4	2011	Here, we sought to evaluate the potential to deliver a fractalkine (FKN)-encoding plasmid formulated with the tetrafunctional amphiphilic block copolymer 704 through aerosolization in two models of pulmonary metastases.	copolymer	144-153	chemokine (C-X3-C motif) ligand 1	Mus musculus	55-66
21693131-3	2011	The graft copolymer has been characterized by FTIR, XRD, TGA and SEM analysis.	copolymer	10-19	T-box transcription factor 1	Homo sapiens	57-60
21894346-6	2011	These TNW and TNT films were further coated with the graft copolymer-directed mesoporous TiO(2) and were used as interfacial layers between the FTO glass and the 4 mum thick nanocrystalline TiO(2) film.	copolymer	59-68	chromosome 16 open reading frame 82	Homo sapiens	14-17
21863843-0	2011	Structure of micelles of a nonionic block copolymer determined by SANS and SAXS.	copolymer	42-51	USH1 protein network component sans	Homo sapiens	66-70
22076772-0	2011	Effect of pluronic P123 and F127 block copolymer on P-glycoprotein transport and CYP3A metabolism.	copolymer	39-48	ATP binding cassette subfamily B member 1	Homo sapiens	52-66
21268025-2	2011	A sufficient glucose sensitivity of the copolymer was accomplished by the glucose-induced volume changes of the nanoparticles and release profiles of insulin in phosphate buffered saline (PBS, pH 7.4) with different glucose concentrations, which occurred in a remarkable glucose concentration-dependent manner.	copolymer	40-49	insulin	Homo sapiens	150-157
21591790-1	2011	The association of a symmetric polyoxyethylene-polyoxypropylene-polyoxyethylene (PEO(19)-PPO(29)-PEO(19)) triblock copolymer adsorbed from aqueous solutions onto polypropylene (PP), polyethylene (PE), and cellulose surfaces was probed using Atomic Force Microscopy (AFM).	copolymer	115-124	protoporphyrinogen oxidase	Homo sapiens	89-92
21315564-4	2011	GPC results clarified that the composition of the block copolymer, the concentration of PVA in the aqueous bulk phase, and the temperature during the preparation were the important preparation factors affecting preferential formation of the trilayered polymeric micelles.	copolymer	56-65	glycophorin C (Gerbich blood group)	Homo sapiens	0-3
21426935-10	2011	Copolymer 3a induces Nrf2-driven NQO1 expression in a concentration dependent manner.	copolymer	0-9	NFE2 like bZIP transcription factor 2	Homo sapiens	21-25
21398045-5	2011	Glatiramer acetate (GA; also known as Copaxone, COP-1) is a synthetic copolymer of a pool of peptides composed of random sequences of four amino acids: glutamine, lysine, alanine, and tyrosine.	copolymer	70-79	COP1 E3 ubiquitin ligase	Homo sapiens	48-53
21421037-5	2011	On the other hand, the poly(acrylic acid) grafted inulin copolymer, characterized using (1)H NMR, FTIR, TGA, and SEM techniques, was found to form highly consistent amorphous systems of two-dimensional surfaces with some voids topology.	copolymer	57-66	T-box transcription factor 1	Homo sapiens	104-107
21539329-6	2011	Electron microscopic analysis (SEM and TEM) revealed that the morphology of the copolymer nanomaterials transformed from nanofiber to nanospheres via nanorods upon increasing the composition of pyrrole in the feed.	copolymer	80-89	MFT2	Homo sapiens	39-42
21426935-10	2011	Copolymer 3a induces Nrf2-driven NQO1 expression in a concentration dependent manner.	copolymer	0-9	NAD(P)H quinone dehydrogenase 1	Homo sapiens	33-37
21111850-3	2011	Tyrosinase was employed to convert tyramine-conjugated micelles to highly reactive catechol conjugated micelles that could further cross-link individual Pluronic copolymer micelles to form a highly stable gel structure.	copolymer	162-171	tyrosinase	Homo sapiens	0-10
21366220-2	2011	Well-defined double hydrophilic block copolymer (DHBC) bearing naphthalimide-based Hg(2+)-reactive moieties (NUMA, 4), PEO-b-P(NIPAM-co-NAS-co-NUMA), was synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization, where PEO, NIPAM, and NAS represent poly(ethylene oxide), N-isopropylacrylamide, and N-acryloxysuccinimide.	copolymer	38-47	nuclear mitotic apparatus protein 1	Homo sapiens	109-113
21366220-2	2011	Well-defined double hydrophilic block copolymer (DHBC) bearing naphthalimide-based Hg(2+)-reactive moieties (NUMA, 4), PEO-b-P(NIPAM-co-NAS-co-NUMA), was synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization, where PEO, NIPAM, and NAS represent poly(ethylene oxide), N-isopropylacrylamide, and N-acryloxysuccinimide.	copolymer	38-47	nuclear mitotic apparatus protein 1	Homo sapiens	143-147
21146964-3	2011	The copolymer was coated onto the FT-SPR chip and vacuum-dried, hydrated at 70 C, and treated with a blocking agent respectively to achieve different surface status.	copolymer	4-13	sepiapterin reductase	Homo sapiens	37-40
21366279-1	2011	The formation of high concentration gold nanoparticles at room temperature is reported in block copolymer-mediated synthesis where the nanoparticles have been synthesized from hydrogen tetrachloroaureate(III) hydrate (HAuCl(4) 3H(2)O) using block copolymer P85 (EO(26)PO(39)EO(26)) in aqueous solution.	copolymer	96-105	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	257-260
21340689-1	2011	The present paper reports the utilization of hybrid nanocomposite particles consisting of PEI25k-PEG5k copolymer grafted silica nanoparticles (SiO(2)NPs) for enhanced cellular uptake and siRNA delivery.	copolymer	103-112	neuronatin	Homo sapiens	97-101
21154473-1	2011	Cationic micellar nanoparticles self-assembled from a biodegradable amphiphilic copolymer have been used to deliver human TRAIL and paclitaxel simultaneously.	copolymer	80-89	TNF superfamily member 10	Homo sapiens	122-127
21255790-4	2011	The equilibrium sorption properties of the copolymer sorbents in aqueous solution were characterized using isotherm models at pH 4.6 and 9.0 for PNP, pH 9.0 for naphthenates and pH 10.5 for phth.	copolymer	43-52	purine nucleoside phosphorylase	Homo sapiens	145-148
21314184-6	2011	A cholesterol-anchored, graft copolymer, composed of a short peptide sequence for urokinase plasminogen activator (uPA) and poly(acrylic acid), was synthesized and incorporated into liposomes prepared at high osmolarities.	copolymer	30-39	plasminogen activator, urokinase	Homo sapiens	82-113
21314184-6	2011	A cholesterol-anchored, graft copolymer, composed of a short peptide sequence for urokinase plasminogen activator (uPA) and poly(acrylic acid), was synthesized and incorporated into liposomes prepared at high osmolarities.	copolymer	30-39	plasminogen activator, urokinase	Homo sapiens	115-118
21255790-11	2011	PNP showed significant binding onto the copolymer framework containing diisocyanate domains, whereas, negligible sorption to the sites was observed for phth and naphthenates.	copolymer	40-49	purine nucleoside phosphorylase	Homo sapiens	0-3
21254227-3	2011	In case of the random copolymer poly(methyl methacrylate-co-7-(2"-methacryloyloxyethoxy)-4-methylcoumarin) three dimers have been identified of which the syn head-to-tail was the predominant one.	copolymer	22-31	synemin	Homo sapiens	154-157
21115281-1	2011	Chitosan-polycaprolactone (CPC) copolymer microspheres loaded with transforming growth factor-beta1 (TGF-beta1) were fabricated with an emulsification method using sodium tripolyphosphate as crosslinker.	copolymer	32-41	transforming growth factor beta 1	Homo sapiens	67-99
21115281-1	2011	Chitosan-polycaprolactone (CPC) copolymer microspheres loaded with transforming growth factor-beta1 (TGF-beta1) were fabricated with an emulsification method using sodium tripolyphosphate as crosslinker.	copolymer	32-41	transforming growth factor beta 1	Homo sapiens	101-110
21121600-2	2011	The molecular structures and characteristics of this copolymer and its precursors were confirmed by (1)H NMR, FT-IR, and GPC.	copolymer	53-62	glycophorin C (Gerbich blood group)	Homo sapiens	110-124
20951500-7	2011	Glatiramer acetate (GA, Copolymer 1, Copaxone) an immunomodulator with proven safety and efficacy in Multiple Sclerosis has been reported to cause elevated secretion of BDNF both in animal model and in MS patients.	copolymer	24-33	brain derived neurotrophic factor	Homo sapiens	169-173
20888041-3	2011	Chromatograms of two proteins indicated that negatively-charged HSA was adsorbed on the cationic copolymer brush modified silica beads at higher temperatures with low concentration of phosphate buffer (PB) (pH 7.0) as a mobile phase.	copolymer	97-106	albumin	Homo sapiens	64-67
20888041-4	2011	The HSA adsorption was attributed to (1) an enhanced electrostatic interaction with the cationic copolymer brush at low concentration of PB and (2) an increased hydrophobic interaction from the dehydrated copolymer at high temperature.	copolymer	97-106	albumin	Homo sapiens	4-7
20888041-5	2011	Step-temperature gradient enabled HSA and gamma-globulin to be separated by the modulation of HSA adsorption/desorption onto the copolymer brush grafted silica beads.	copolymer	129-138	albumin	Homo sapiens	34-37
20888041-5	2011	Step-temperature gradient enabled HSA and gamma-globulin to be separated by the modulation of HSA adsorption/desorption onto the copolymer brush grafted silica beads.	copolymer	129-138	albumin	Homo sapiens	94-97
21093476-7	2011	The hydrodynamic radius of the aggregate of copolymer in dilute solution was found to increase with the increasing of the grafted PCL content.	copolymer	44-53	PHD finger protein 1	Homo sapiens	130-133
21077884-8	2010	Protein adsorption on a biomaterial surface is critical to understanding its biocompatibility and bovine serum albumin was used to model that behaviour on the block copolymer surfaces.	copolymer	165-174	albumin	Homo sapiens	105-118
21931487-7	2011	Moreover, the copolymer of 2ME with MNPs- Fe(3)O(4) blocked a nearly two-fold increase in SKM-1 cells located in G(2)/M phase than in 2ME alone, which may be associated with an accompanying increase of p21 as well as a decrease in cyclin B1 and cdc2 expression, but there was no obvious difference between the MNPs-Fe(3)O(4) and control group.	copolymer	14-23	H3 histone pseudogene 16	Homo sapiens	202-205
21931487-7	2011	Moreover, the copolymer of 2ME with MNPs- Fe(3)O(4) blocked a nearly two-fold increase in SKM-1 cells located in G(2)/M phase than in 2ME alone, which may be associated with an accompanying increase of p21 as well as a decrease in cyclin B1 and cdc2 expression, but there was no obvious difference between the MNPs-Fe(3)O(4) and control group.	copolymer	14-23	cyclin B1	Homo sapiens	231-240
21931487-7	2011	Moreover, the copolymer of 2ME with MNPs- Fe(3)O(4) blocked a nearly two-fold increase in SKM-1 cells located in G(2)/M phase than in 2ME alone, which may be associated with an accompanying increase of p21 as well as a decrease in cyclin B1 and cdc2 expression, but there was no obvious difference between the MNPs-Fe(3)O(4) and control group.	copolymer	14-23	cyclin dependent kinase 1	Homo sapiens	245-249
21042630-4	2011	The highly enhanced field due to lightning-rod effects and localized surface plasmons excited at the end of the gold-coated tip allowed us to resolve and identify metallic nanoparticles embedded in poly(methyl methacrylate) as well as microphases in microphase-separated block copolymer films.	copolymer	277-286	TOR signaling pathway regulator	Homo sapiens	124-127
21607935-4	2011	In addition, it was analyzed whether covalent linkage of Bone Morphogenetic Protein 2 (BMP-2) to the copolymer layer enhances bone formation.	copolymer	101-110	bone morphogenetic protein 2	Oryctolagus cuniculus	57-85
21607935-4	2011	In addition, it was analyzed whether covalent linkage of Bone Morphogenetic Protein 2 (BMP-2) to the copolymer layer enhances bone formation.	copolymer	101-110	bone morphogenetic protein 2	Oryctolagus cuniculus	87-92
21607935-9	2011	In contrast, this in-vivo study showed that the immobilization of BMP-2 onto the copolymer layer did not enhance bone healing.	copolymer	81-90	bone morphogenetic protein 2	Oryctolagus cuniculus	66-71
21607935-11	2011	CONCLUSION: The analysis showed that the bone remodeling process in the copolymer + BMP-2-group is in an early phase comparable to the control group.	copolymer	72-81	bone morphogenetic protein 2	Oryctolagus cuniculus	84-89
21736523-2	2011	The in vitro experiments performed on insulin-loaded microparticles in pH 1.2 media (stomach condition) demonstrated no release of insulin in the first 2 h, but almost 100% insulin was released in pH 7.4 media (intestinal condition) in 6 h. The carrier was characterized by Fourier transform infrared, differential scanning calorimeter, thermogravimetry and nuclear magnetic resonance techniques to confirm the formation of copolymer, while scanning electron microscopy was used to assess the morphology of hydrogel microparticles.	copolymer	424-433	insulin	Homo sapiens	38-45
21182416-3	2011	Packaging of catalase into block ionomer complex with a synthetic polyelectrolyte block copolymer precludes enzyme degradation in macrophages.	copolymer	88-97	catalase	Mus musculus	13-21
21077884-9	2010	An increase in the adhesive force of the surface was observed to correlate with the adsorption of bovine serum albumin on the block copolymer surfaces investigated.	copolymer	132-141	albumin	Homo sapiens	105-118
20845065-7	2010	CONCLUSION: HPMA copolymer aminohexylgeldanamycin conjugates bearing WIFPWIQL peptide have the ability to bind to cell-surface-expressed GRP78 and inhibit the growth of human prostate cancer cells, suggesting that the conjugates have the potential to target solid prostate cancer tumors.	copolymer	17-26	heat shock protein family A (Hsp70) member 5	Homo sapiens	137-142
20964305-2	2010	The vesicles are prepared via a simple and spontaneous migration of poly(butadiene-b-ethylene oxide) (PB-PEO) block copolymer vesicles from a hydrophobic ionic liquid, 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ([EMIM][TFSI]), to water at room temperature.	copolymer	116-125	twinkle mtDNA helicase	Homo sapiens	105-108
20195708-1	2010	PURPOSE: Block copolymer micelles (BCMs) were functionalized with indium-111 and/or epidermal growth factor (EGF), which enabled investigation of the in vivo transport of passively and actively targeted BCMs.	copolymer	15-24	epidermal growth factor	Homo sapiens	84-107
21128720-6	2010	A notable dependence of the anti-P-gp activity on the copolymer concentration was found.	copolymer	54-63	ATP binding cassette subfamily B member 1	Homo sapiens	33-37
20889541-3	2010	We used a thermosensitive biodegradable copolymer (hydrogel) system to codeliver HBsAg and GM-CSF to achieve maximal local cytokine activity at the injection site.	copolymer	40-49	colony stimulating factor 2	Homo sapiens	91-97
20195708-1	2010	PURPOSE: Block copolymer micelles (BCMs) were functionalized with indium-111 and/or epidermal growth factor (EGF), which enabled investigation of the in vivo transport of passively and actively targeted BCMs.	copolymer	15-24	epidermal growth factor	Homo sapiens	109-112
20300804-7	2010	Infection of PC-3 and LNCaP prostate cancer cells was ~100-fold less efficient with copolymer-coated Ad than with un-modified Ad.	copolymer	84-93	chromobox 8	Homo sapiens	13-17
20526655-3	2010	ATR/FTIR and (1)H NMR spectra of the copolymer showed absence of vinyl bond/protons present in the monomers suggesting successful polymerization.	copolymer	37-46	ATR serine/threonine kinase	Homo sapiens	0-3
20599266-2	2010	PEG-PCL-PDEA copolymers with M(n)(PEG) = 5 kg/mol, M(n)(PCL) = 18.2 kg/mol, and short PDEA blocks ranging from 1.1, 2.7 to 4.1 kg/mol (denoted as copolymer 1, 2 and 3, respectively) were obtained by controlled reversible addition-fragmentation chain transfer (RAFT) polymerization.	copolymer	13-22	phosphodiesterase 6A, cGMP-specific, rod, alpha	Mus musculus	8-12
20603143-1	2010	Microwave induced copolymerization of beta-cyclodextrin (beta-CD) and chitosan (Ch) resulted in copolymer Ch-g-beta-CD synthesized without any radical initiator or catalyst.	copolymer	18-27	succinate-CoA ligase GDP-forming subunit beta	Homo sapiens	109-115
20603143-2	2010	Copolymer samples of different performances in terms of Pb(II) binding were synthesized by changing beta-CD concentration at fixed microwave power and exposure time.	copolymer	0-9	submaxillary gland androgen regulated protein 3B	Homo sapiens	56-62
20603143-6	2010	On the basis of the Langmuir model, Q(max) was calculated to be 434.78mg/g for microwave synthesized copolymer (Ch-g-beta-CD) in comparison to 294.11mg/g for conventionally synthesized copolymer (Ch-g-beta-CD).	copolymer	101-110	succinate-CoA ligase GDP-forming subunit beta	Homo sapiens	115-121
20603143-6	2010	On the basis of the Langmuir model, Q(max) was calculated to be 434.78mg/g for microwave synthesized copolymer (Ch-g-beta-CD) in comparison to 294.11mg/g for conventionally synthesized copolymer (Ch-g-beta-CD).	copolymer	101-110	succinate-CoA ligase GDP-forming subunit beta	Homo sapiens	199-205
20737079-1	2010	Attachment of a copolymer of silafluorene and fluorene to 100 nm hollow silica nanoparticles provides a new method to detect aqueous TNT and RDX with a low detection limit using the suspended fluorescent nanoshells.	copolymer	16-25	radixin	Homo sapiens	141-144
20566205-3	2010	These consisted of the E(T)(30) probe in boxes of water molecules, in the presence of an isolated block copolymer of formula (PEO)(11)-(PPO)(16)-(PEO)(11), and of a micelle formed of 50 of these unimers.	copolymer	104-113	protoporphyrinogen oxidase	Homo sapiens	136-139
21344059-8	2010	Salmon calcitonin release was minimal from the copolymer with 4:1 MAA:NVP monomer feed at pH 7.4.	copolymer	47-56	calcitonin related polypeptide alpha	Homo sapiens	7-17
21567558-2	2010	In solution, this side-chain copolymer adopts a globular architecture and about five molecules of the water-insoluble chromophore PDI were successfully incorporated into these micelles for receptor-mediated cell uptake investigations.	copolymer	29-38	peptidyl arginine deiminase 1	Homo sapiens	130-133
19967748-4	2010	We targeted oligonucleotide sequences within the human c-myc mRNA as free AS ODNs or conjugated with a thermosensitive copolymer, in an effort to inhibit the growth of human melanoma cells.	copolymer	119-128	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	55-60
20663032-2	2010	METHODS: Copolymer of polyethyleneglycol allylmethylether and maleamic acid sodium salt with OCIF (poly(PEG)-OCIF) (0.5 mg/kg) was administered to rats and the concentrations of poly(PEG)-OCIF in the liver, kidney and spleen at 15 min after administration were measured by ELISA.	copolymer	9-18	basic transcription factor 3 pseudogene 11	Homo sapiens	93-97
20663032-2	2010	METHODS: Copolymer of polyethyleneglycol allylmethylether and maleamic acid sodium salt with OCIF (poly(PEG)-OCIF) (0.5 mg/kg) was administered to rats and the concentrations of poly(PEG)-OCIF in the liver, kidney and spleen at 15 min after administration were measured by ELISA.	copolymer	9-18	basic transcription factor 3 pseudogene 11	Homo sapiens	109-113
20663032-2	2010	METHODS: Copolymer of polyethyleneglycol allylmethylether and maleamic acid sodium salt with OCIF (poly(PEG)-OCIF) (0.5 mg/kg) was administered to rats and the concentrations of poly(PEG)-OCIF in the liver, kidney and spleen at 15 min after administration were measured by ELISA.	copolymer	9-18	basic transcription factor 3 pseudogene 11	Homo sapiens	109-113
20472422-3	2010	Due to the biocompatible microenvironment provided by the copolymer network, the obtained composite was devised for AChE attachment, resulting in a stable AChE biosensor for screening of organophosphates (OPs) exposure.	copolymer	58-67	acetylcholinesterase (Cartwright blood group)	Homo sapiens	116-120
20472422-3	2010	Due to the biocompatible microenvironment provided by the copolymer network, the obtained composite was devised for AChE attachment, resulting in a stable AChE biosensor for screening of organophosphates (OPs) exposure.	copolymer	58-67	acetylcholinesterase (Cartwright blood group)	Homo sapiens	155-159
20480092-1	2010	We present an extensive study of ionic transport in PolyG(30)LiPF(6), which is a crosslinked poly(ethylene oxide)-poly(propylene oxide(PEO-PPO) random copolymer complexed with LiPF(6) to an oxygen-to-cation ratio of 30 : 1.	copolymer	151-160	lipase F, gastric type	Homo sapiens	61-65
20201484-2	2010	We have demonstrated that the F127 block copolymer ((PEO)(106)(PPO)(70)(PEO)(106)), "F type", mesostructured silica film is a suitable "soft" template for the fabrication of spherical silver nanoparticles arrays.	copolymer	41-50	protoporphyrinogen oxidase	Homo sapiens	63-66
20201484-5	2010	Using a P123 block copolymer ((PEO)(20)(PPO)(70)(PEO)(20)), "P type", mesostructured silica film, we have obtained silver nanowires with typical dimension of 10 nm x 100 nm.	copolymer	19-28	protoporphyrinogen oxidase	Homo sapiens	40-43
20476759-1	2010	The current study describes the impact of particle size and/or molecular targeting (epidermal growth factor, EGF) on the in vivo transport of block copolymer micelles (BCMs) in athymic mice bearing human breast cancer xenografts that express differential levels of EGF receptors (EGFR).	copolymer	148-157	epidermal growth factor	Mus musculus	109-112
20565093-1	2010	Two end-decorated homopolymers, poly(styrene)-beta-cyclodextrin (PS-beta-CD) and poly(ethylene oxide)-ferrocene (PEO-Fc), can orthogonally self-assemble into a supramolecular diblock copolymer (PS-beta-CD/PEO-Fc) in aqueous solutions based on the terminal host-guest interactions.	copolymer	183-192	pregnancy specific beta-1-glycoprotein 1	Homo sapiens	32-63
20565093-1	2010	Two end-decorated homopolymers, poly(styrene)-beta-cyclodextrin (PS-beta-CD) and poly(ethylene oxide)-ferrocene (PEO-Fc), can orthogonally self-assemble into a supramolecular diblock copolymer (PS-beta-CD/PEO-Fc) in aqueous solutions based on the terminal host-guest interactions.	copolymer	183-192	pregnancy specific beta-1-glycoprotein 1	Homo sapiens	65-75
20471369-8	2010	Notably, copolymer that consists of 1:10 mixture of the mutant and wild-type actin molecules showed significantly reduced affinity for cofilin, suggesting that G146V mutant actin affects the conformation of neighboring wild-type actin within a filament, and inhibits cofilin binding.	copolymer	9-18	actin	Saccharomyces cerevisiae S288C	77-82
20471369-8	2010	Notably, copolymer that consists of 1:10 mixture of the mutant and wild-type actin molecules showed significantly reduced affinity for cofilin, suggesting that G146V mutant actin affects the conformation of neighboring wild-type actin within a filament, and inhibits cofilin binding.	copolymer	9-18	cofilin	Saccharomyces cerevisiae S288C	135-142
20471369-8	2010	Notably, copolymer that consists of 1:10 mixture of the mutant and wild-type actin molecules showed significantly reduced affinity for cofilin, suggesting that G146V mutant actin affects the conformation of neighboring wild-type actin within a filament, and inhibits cofilin binding.	copolymer	9-18	actin	Saccharomyces cerevisiae S288C	173-178
20471369-8	2010	Notably, copolymer that consists of 1:10 mixture of the mutant and wild-type actin molecules showed significantly reduced affinity for cofilin, suggesting that G146V mutant actin affects the conformation of neighboring wild-type actin within a filament, and inhibits cofilin binding.	copolymer	9-18	actin	Saccharomyces cerevisiae S288C	173-178
20471369-8	2010	Notably, copolymer that consists of 1:10 mixture of the mutant and wild-type actin molecules showed significantly reduced affinity for cofilin, suggesting that G146V mutant actin affects the conformation of neighboring wild-type actin within a filament, and inhibits cofilin binding.	copolymer	9-18	cofilin	Saccharomyces cerevisiae S288C	267-274
20215041-7	2010	At any particular copolymer composition the rate of degradation follows the order: SBMA>SEMA>SMMA.	copolymer	18-27	androgen receptor	Homo sapiens	83-87
20215041-7	2010	At any particular copolymer composition the rate of degradation follows the order: SBMA>SEMA>SMMA.	copolymer	18-27	semaphorin 3B	Homo sapiens	91-95
20182931-5	2010	Thin mucin coatings decreased the numbers of bacteria but increased the numbers of C. albicans adhering to the copolymer and control surfaces.	copolymer	111-120	mucin 1, cell surface associated	Bos taurus	5-10
20156625-1	2010	The micellization mechanism of PEO-PPO-PEO block copolymer in aqueous solutions was studied by two-dimensional correlation FTIR spectroscopy.	copolymer	49-58	protoporphyrinogen oxidase	Homo sapiens	35-38
20179998-9	2010	The log ratio of the dual band fluorescence emission (log (I(N*)/I(T*))) of 3-HF doped, dry, NIPAM-NtBA copolymer films were found to depend linearly on copolymer composition, with increasing hydrophobicity (greater NtBA fraction) leading to a decrease in the value of log (I(N*)/I(T*)).	copolymer	104-113	SLAM family member 6	Homo sapiens	99-103
20205374-2	2010	Copolymer composition data, obtained using pulsed laser polymerization followed by size exclusion chromatography (PLP-SEC) and proton nuclear magnetic resonance (NMR), were well represented by the terminal model using monomer reactivity ratios obtained with the computational approach (r(VAc) = 0.001 and r(MMA) = 27.9).	copolymer	0-9	proteolipid protein 1	Homo sapiens	114-117
19967780-3	2010	To this end, we are studying encapsulation and delivery of Pc 4 in block copolymer micelles.	copolymer	73-82	proprotein convertase subtilisin/kexin type 4	Homo sapiens	59-63
20045182-1	2010	In this work, we report a tunable mixed-charge copolymer surface containing positively charged quaternary amine monomers ([2-(acryloyloxy)ethyl] trimethyl ammonium chloride, TMA) and negatively-charged carboxylic acid monomers (2-carboxy ethyl acrylate, CAA).	copolymer	47-56	teashirt zinc finger homeobox 1	Homo sapiens	254-257
20175565-4	2010	A new paper in this issue of ACS Nano discusses a new form of printing that utilizes block copolymer assemblies as ink reservoirs for pattern transfer.	copolymer	91-100	1-aminocyclopropane-1-carboxylate synthase homolog (inactive)	Homo sapiens	29-32
20152984-3	2010	Here we report a facile one-step chemical synthesis of a new aldehyde-bearing graft copolymer via atom transfer radical polymerization (ATRP) for covalent protein capture in a multilayered approach to covalently capture bovine serum albumin (BSA) onto a polymeric membrane.	copolymer	84-93	albumin	Homo sapiens	227-240
20095618-2	2010	The amphiphilic rod-coil block copolymer of polyphenylene-b-poly(2-vinyl pyridine) (PPH-PVP) was first prepared from its coil-coil precursor block copolymer of poly(1,3-cyclohexadiene)-b-poly(2-vinyl pyridine) (PCHD-PVP) by using sequential anionic polymerization followed by the aromatization reaction of converting the PCHD block to form conducting PPH.	copolymer	31-40	enolase 1	Homo sapiens	84-87
20095618-2	2010	The amphiphilic rod-coil block copolymer of polyphenylene-b-poly(2-vinyl pyridine) (PPH-PVP) was first prepared from its coil-coil precursor block copolymer of poly(1,3-cyclohexadiene)-b-poly(2-vinyl pyridine) (PCHD-PVP) by using sequential anionic polymerization followed by the aromatization reaction of converting the PCHD block to form conducting PPH.	copolymer	31-40	enolase 1	Homo sapiens	351-354
20095618-2	2010	The amphiphilic rod-coil block copolymer of polyphenylene-b-poly(2-vinyl pyridine) (PPH-PVP) was first prepared from its coil-coil precursor block copolymer of poly(1,3-cyclohexadiene)-b-poly(2-vinyl pyridine) (PCHD-PVP) by using sequential anionic polymerization followed by the aromatization reaction of converting the PCHD block to form conducting PPH.	copolymer	147-156	enolase 1	Homo sapiens	84-87
19924993-0	2010	Multifunctional block copolymer micelles for the delivery of 111In to EGFR-positive breast cancer cells for targeted Auger electron radiotherapy.	copolymer	22-31	epidermal growth factor receptor	Homo sapiens	70-74
20302075-3	2010	Additionally, on the base of the process, the oligomer bis(2-hydroxypropyl) sebacate (PSP) was synthesized by similar method and then a kind of new copolymer named poly(propylene fumarate-co-propylene sebacate) [P(PF-co-PS)] that comprised bis(2-hydroxypropyl) sebacate segments was synthesized with PFP and PSP by melting condensation.	copolymer	148-157	microseminoprotein beta	Homo sapiens	86-89
19923567-13	2010	Each block copolymer elicited a different immune response, although always Th1 specific, in BALB/c mice.	copolymer	11-20	negative elongation factor complex member C/D, Th1l	Mus musculus	75-78
20589074-1	2010	An alternating copolymer of styrene and maleic acid (alt-PSMA) differs from other polyanionic antiviral agents in that the negative charges of alt-PSMA are provided by carboxylic acid groups instead of sulfate or sulfonate moieties.	copolymer	15-24	folate hydrolase 1	Homo sapiens	57-61
20589074-1	2010	An alternating copolymer of styrene and maleic acid (alt-PSMA) differs from other polyanionic antiviral agents in that the negative charges of alt-PSMA are provided by carboxylic acid groups instead of sulfate or sulfonate moieties.	copolymer	15-24	folate hydrolase 1	Homo sapiens	147-151
19524625-0	2009	Enhanced magnetic resonance imaging of experimental pancreatic tumor in vivo by block copolymer-coated magnetite nanoparticles with TGF-beta inhibitor.	copolymer	86-95	transforming growth factor beta 1	Homo sapiens	132-140
19524625-4	2009	We developed here block copolymer-coated magnetite nanoparticles for pancreatic cancer imaging, by means of a chelation between the carboxylic acid groups in poly(ethylene glycol)-poly(aspartic acid) block copolymer (PEG-PAsp) and Fe on the surface of the iron oxide nanoparticles.	copolymer	24-33	carboxypeptidase B1	Homo sapiens	221-225
19836550-1	2009	An innovative block copolymer capillary coating P(MAn-alt-St)(127)-b-PSt(592), synthesized by maleic anhydride and styrene, was developed as a new kind of coating for capillary electrophoresis.	copolymer	20-29	sulfotransferase family 1A member 1	Homo sapiens	69-72
19746918-5	2009	Furthermore, we found that the major mechanism of copolymer entry and delivery into E-selectin expressing cells is endocytosis.	copolymer	50-59	selectin E	Homo sapiens	84-94
19882631-1	2009	A new type of block copolymer, which was synthesized by styrene and maleic anhydride, P(MAn-alt-St)(119)-b-PSt(558), was successfully developed as the capillary coatings in open tubular CEC.	copolymer	20-29	sulfotransferase family 1A member 1	Homo sapiens	107-110
19545594-0	2009	Protein kinase C alpha-specific peptide substrate graft-type copolymer for cancer cell-specific gene regulation systems.	copolymer	61-70	protein kinase C, alpha	Mus musculus	0-22
19552909-8	2009	In this paper, it is also discussed that the selectivity enhancement by copolymer-grafting in the Sil-copoly-VP17MA12 phase can be brought through intramolecular interaction between VP and MA.	copolymer	72-81	STIL centriolar assembly protein	Homo sapiens	98-101
19821626-0	2009	ABC triblock surface active block copolymer with grafted ethoxylated fluoroalkyl amphiphilic side chains for marine antifouling/fouling-release applications.	copolymer	34-43	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	0-3
19588920-0	2009	A general methodology toward drug/dye incorporated living copolymer-protein hybrids: (NIRF dye-glucose) copolymer-avidin/BSA conjugates as prototypes.	copolymer	58-67	interleukin 17B	Homo sapiens	86-90
19736995-1	2009	Biodegradable poly(epsilon-caprolactone)/poly(ethylene glycol) (PCL/PEG) copolymer nanoparticles showed potential application in drug delivery systems.	copolymer	73-82	polycystic kidney disease 2-like 1	Mus musculus	64-67
19637909-0	2009	Reverse thermal gelation of PAF-PLX-PAF block copolymer aqueous solution.	copolymer	46-55	PCNA clamp associated factor	Homo sapiens	28-31
19637909-0	2009	Reverse thermal gelation of PAF-PLX-PAF block copolymer aqueous solution.	copolymer	46-55	PCNA clamp associated factor	Homo sapiens	36-39
19588920-0	2009	A general methodology toward drug/dye incorporated living copolymer-protein hybrids: (NIRF dye-glucose) copolymer-avidin/BSA conjugates as prototypes.	copolymer	104-113	interleukin 17B	Homo sapiens	86-90
19464019-2	2009	The copolymer can disperse in aqueous media at room temperature to self-assemble into pH- and thermo-responsive core-shell-corona micelles, with the hydrophobic PSt block as core, the pH-sensitive PSMA block as shell, and the thermo-sensitive PNIPAAm block as corona.	copolymer	4-13	sulfotransferase family 1A member 1	Homo sapiens	161-164
19464019-2	2009	The copolymer can disperse in aqueous media at room temperature to self-assemble into pH- and thermo-responsive core-shell-corona micelles, with the hydrophobic PSt block as core, the pH-sensitive PSMA block as shell, and the thermo-sensitive PNIPAAm block as corona.	copolymer	4-13	folate hydrolase 1	Homo sapiens	197-201
19342094-0	2009	Block-copolymer micelles as carriers of cell signaling modulators for the inhibition of JNK in human islets of Langerhans.	copolymer	6-15	mitogen-activated protein kinase 8	Homo sapiens	88-91
19678985-2	2009	The adsorbed mucin layer on the copolymer surface had the greatest thickness (17 nm) when adsorbed from a mucin solution at a pH of 3.	copolymer	32-41	mucin 1, cell surface associated	Bos taurus	13-18
19678985-2	2009	The adsorbed mucin layer on the copolymer surface had the greatest thickness (17 nm) when adsorbed from a mucin solution at a pH of 3.	copolymer	32-41	mucin 1, cell surface associated	Bos taurus	106-111
19678985-9	2009	The IR ellipsometry data also indicated some changes in the conformational states of the side groups in the copolymer induced by entanglements and bonding interactions with the mucin macromolecules.	copolymer	108-117	mucin 1, cell surface associated	Bos taurus	177-182
19531023-8	2009	The results indicated that copolymer compositions containing at least 50% CPH induced elevated amounts of TNFalpha.	copolymer	27-36	tumor necrosis factor	Mus musculus	106-114
19354273-5	2009	The overall fluorescence data suggest that the PAAMePy55 and the P123 block copolymer associate strongly at low pH, leading to the formation of P123 micelles surrounded by one PAAMePy55 chain, where the pyrene groups are located at the PPO/PEO interface of the P123 micelles.	copolymer	76-85	protoporphyrinogen oxidase	Homo sapiens	236-239
19491032-3	2009	The precursor, a copolymer of N-(2-hydroxypropyl)methacrylamide (HPMA) bearing hydrazide groups randomly distributed along the polymer chain, was conjugated with DOX (through its C13 keto group) or with a keto ester (DEX).	copolymer	17-26	homeobox C13	Homo sapiens	179-182
19438706-5	2009	By using fractionated lipoproteins, we show that HDL binds to copolymer nanoparticles with much higher specificity than other lipoproteins, probably mediated by apolipoprotein A-I.	copolymer	62-71	apolipoprotein A1	Homo sapiens	161-179
19354273-5	2009	The overall fluorescence data suggest that the PAAMePy55 and the P123 block copolymer associate strongly at low pH, leading to the formation of P123 micelles surrounded by one PAAMePy55 chain, where the pyrene groups are located at the PPO/PEO interface of the P123 micelles.	copolymer	76-85	twinkle mtDNA helicase	Homo sapiens	240-243
19267435-0	2009	A porous coordination copolymer with over 5000 m2/g BET surface area.	copolymer	22-31	delta/notch like EGF repeat containing	Homo sapiens	52-55
21706644-2	2009	One copolymer, DNPIM-33, has an excellent combination of properties with good film-forming characteristics and gas transport performance, and exhibits higher selectivity than the corresponding spirobisindane-based homopolymer PIM-1 for gas pairs, such as O(2) /N(2) , with a corresponding small decrease in permeability.	copolymer	4-13	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	226-231
19175305-0	2009	Self-associating poly(ethylene oxide)-b-poly(alpha-cholesteryl carboxylate-epsilon-caprolactone) block copolymer for the solubilization of STAT-3 inhibitor cucurbitacin I.	copolymer	103-112	signal transducer and activator of transcription 3	Homo sapiens	139-145
21706625-3	2009	Moreover, thin films of this copolymer, cast from THF solution, undergo almost instantaneous fluorescence quenching when exposed to the vapour of 2,5-dinitrobenzonitrile (a model for TNT) at ambient temperatures and pressures.	copolymer	29-38	chromosome 16 open reading frame 82	Homo sapiens	183-186
19167975-9	2009	RESULTS: The PCT copolymer had no effect on the proliferation of cultured cells in vitro.	copolymer	17-26	calcitonin related polypeptide alpha	Homo sapiens	13-16
18677571-1	2009	A synthetic amphiphilic block copolymer Pluronic P85 (P85) was shown to be among the most potent inhibitors of Pgp efflux system in the blood-brain barrier (BBB) and capable of enhancing delivery of Pgp substrates to the brain.	copolymer	30-39	phosphoglycolate phosphatase	Bos taurus	111-114
18677571-1	2009	A synthetic amphiphilic block copolymer Pluronic P85 (P85) was shown to be among the most potent inhibitors of Pgp efflux system in the blood-brain barrier (BBB) and capable of enhancing delivery of Pgp substrates to the brain.	copolymer	30-39	phosphoglycolate phosphatase	Bos taurus	199-202
19212064-0	2009	Colorimetric assay of aminopeptidase N activity based on inhibition of the disassembly of gold nano-composites conjugated with a thermo-responsive copolymer.	copolymer	147-156	alanyl aminopeptidase, membrane	Homo sapiens	22-38
19212064-1	2009	A colorimetric change of gold nano-composites conjugated with a thermo-responsive copolymer has been applied to a colorimetric assay to quantify the activity of aminopeptidase N (APN).	copolymer	82-91	alanyl aminopeptidase, membrane	Homo sapiens	161-177
19212064-1	2009	A colorimetric change of gold nano-composites conjugated with a thermo-responsive copolymer has been applied to a colorimetric assay to quantify the activity of aminopeptidase N (APN).	copolymer	82-91	alanyl aminopeptidase, membrane	Homo sapiens	179-182
18386840-1	2009	This study aimed to analyze surface morphology and physical-chemical properties of a copolymer of polylactic/polyglycolic acid (Fisiograft, Ghimas SpA, Casalecchio di Reno, Italy) by scanning electron microscopy (SEM), porosimetry, and rheological analysis.	copolymer	85-94	surfactant protein A2	Homo sapiens	147-150
19027745-6	2009	We found that genetic immunization, carried out especially through DNA electroporation and, to a lesser extent, through injection of block copolymer-protected DNA, was able to generate high amounts of antibodies recognizing native PrP as expressed on the cell surface.	copolymer	139-148	prion protein	Homo sapiens	231-234
19058844-5	2009	The functional coupling of bFGF to the glyco-block copolymer surfaces was further proven by the dose-dependent response of endothelial cell proliferation.	copolymer	51-60	fibroblast growth factor 2	Homo sapiens	27-31
19167975-3	2009	METHODS: PCT copolymer membranes were produced by polymerization of the monomers, dissolution in organic solvents, and subsequently processing them by means of modified phase inversion and freeze drying.	copolymer	13-22	calcitonin related polypeptide alpha	Homo sapiens	9-12
19167975-16	2009	Therefore, the PCT copolymer represents a candidate for additional clinical evaluation.	copolymer	19-28	calcitonin related polypeptide alpha	Homo sapiens	15-18
18661107-1	2008	Biodegradable elastic poly(L-lactide-co-epsilon-caprolactone) (PLCL) (50:50) copolymer was blended with collagen (0.05, 0.1 and 0.2% w/w) in an acidic dioxane solution to form a collagen/PLCL hybrid material suitable for tissue engineering applications.	copolymer	77-86	phospholipase C-like 1	Mus musculus	63-67
18550277-0	2009	A comparative study of natural, formaldehyde-treated and copolymer-grafted orange peel for Pb(II) adsorption under batch and continuous mode.	copolymer	57-66	submaxillary gland androgen regulated protein 3B	Homo sapiens	91-97
21706588-2	2009	It is found that addition of a carefully designed copolymer PS-b-P(S-ran-MMA) (SSM) compatibilizer could convert the morphology into a co-continuous system.	copolymer	50-59	monocyte to macrophage differentiation associated	Homo sapiens	73-76
19649596-2	2009	The epitope mapping of CgA has been carried out by peptide microarrays on glass slides coated by a copolymer of N,N-dimethylacrylamide (DMA), N,N-acryloyloxysuccinimide (NAS) and [3-(methacryloyl-oxy) propyl] trimethoxysilyl (MAPS).	copolymer	99-108	chromogranin A	Homo sapiens	23-26
18393290-7	2008	In conclusion, this study provides evidence that a block-copolymer, Pluronic P85, effectively inhibits the interaction of P-gp with nelfinavir and saquinavir.	copolymer	57-66	phosphoglycolate phosphatase	Homo sapiens	122-126
18828615-0	2008	Formation of annexin-a5 protein/block copolymer micelle complexes: QCM-D and PAGE experiments.	copolymer	38-47	annexin A5	Homo sapiens	13-23
18722489-3	2008	This work evaluates whether a representative block copolymer, Pluronic P85 (P85) can also prevent development of Dox-induced MDR in leukemia cells.	copolymer	51-60	extracellular matrix protein 1	Mus musculus	71-74
18722489-3	2008	This work evaluates whether a representative block copolymer, Pluronic P85 (P85) can also prevent development of Dox-induced MDR in leukemia cells.	copolymer	51-60	extracellular matrix protein 1	Mus musculus	76-79
18722489-3	2008	This work evaluates whether a representative block copolymer, Pluronic P85 (P85) can also prevent development of Dox-induced MDR in leukemia cells.	copolymer	51-60	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	125-128
18828615-2	2008	Decoration of self-assembled block copolymer nanostructures by Anx5 is of particular interest in micelle-mediated target drug delivery or in vivo magnetic resonance imaging, the Anx5 imparting (bio)functionality to the system.	copolymer	35-44	annexin A5	Homo sapiens	63-67
18828615-2	2008	Decoration of self-assembled block copolymer nanostructures by Anx5 is of particular interest in micelle-mediated target drug delivery or in vivo magnetic resonance imaging, the Anx5 imparting (bio)functionality to the system.	copolymer	35-44	annexin A5	Homo sapiens	178-182
18828615-3	2008	In this work, the reversible binding of the Anx5 onto polystyrene-b-poly(2-phosphatethyl methacrylate-co-2-hydroxyethyl methacrylate) (PS-b-P(PEMA-co-HEMA)) block copolymer micelles in the presence of Ca2+ ions is described using Quartz crystal microbalance with dissipation monitoring (QCM-D) and polyacrylamide gel electrophoresis (PAGE) analysis.	copolymer	163-172	annexin A5	Homo sapiens	44-48
18698867-6	2008	Copolymer adsorption to a liquid-expanded DPPC-d62 monolayer proceeds in a two-step mechanism: (i) initially only the more hydrophobic PPO middle block penetrates the lipid monolayer; (ii) following the liquid-expanded-liquid-condensed (LE-LC) phase transition, the bulky PGMA hydrophilic blocks are dragged into the headgroup region as the PPO block inserts further into the fatty acid region.	copolymer	0-9	protoporphyrinogen oxidase	Homo sapiens	135-138
18755475-3	2008	For the copolymer, the limiting area per segment versus temperature shows a break point around 29 degrees C, slightly lower than the lower critical solution temperature (LCST) of h-PDEA in water (31-33 degrees C).	copolymer	8-17	phosphodiesterase 6A	Homo sapiens	181-185
18698867-6	2008	Copolymer adsorption to a liquid-expanded DPPC-d62 monolayer proceeds in a two-step mechanism: (i) initially only the more hydrophobic PPO middle block penetrates the lipid monolayer; (ii) following the liquid-expanded-liquid-condensed (LE-LC) phase transition, the bulky PGMA hydrophilic blocks are dragged into the headgroup region as the PPO block inserts further into the fatty acid region.	copolymer	0-9	protoporphyrinogen oxidase	Homo sapiens	341-344
18417330-3	2008	ATR-FTIR analysis revealed differences in copolymer composition and based on the copolymer properties, a selection of copolymers was chosen to cast drug-loaded, microporous films that exhibit microencapsulation of drug agglomerates.	copolymer	42-51	ATR serine/threonine kinase	Homo sapiens	0-3
18680342-4	2008	The density of immobilized DNA can be quantitatively controlled by varying the parameters used for spin-coating the copolymer film, that is, solution concentration and rotational speed, or by varying the copolymer molecular weight.	copolymer	116-125	spindlin 1	Homo sapiens	99-103
18620444-2	2008	Here, a pH-responsive copolymer, poly(2-(dimethylamino)ethyl methacrylate)- b-poly(2-(diethylamino)ethyl methacrylate) (PDMA(106)- b-PDEA(25)), has been used to study the formation and dissociation of adsorbed micelles through pH variation.	copolymer	22-31	phosphodiesterase 6A	Homo sapiens	133-137
18417330-3	2008	ATR-FTIR analysis revealed differences in copolymer composition and based on the copolymer properties, a selection of copolymers was chosen to cast drug-loaded, microporous films that exhibit microencapsulation of drug agglomerates.	copolymer	81-90	ATR serine/threonine kinase	Homo sapiens	0-3
18850858-3	2008	Two modeling schemes were employed to describe the SANS data of semidilute copolymer solutions at higher temperature as they contain interacting charged micelles at pH<7.5 and interacting neutral micelles at higher pH.	copolymer	75-84	USH1 protein network component sans	Homo sapiens	51-55
18831937-1	2008	Of various proposed alternatives to autogenous bone, a synthetic, degradable copolymer of PLA-GLA and dextrane seems to be a promising biomaterial for maxillary sinus lift.	copolymer	77-86	galactosidase alpha	Homo sapiens	94-97
18597524-5	2008	The degradation of the copolymer in the presence of combustion-synthesized titania was significantly higher than that observed in the presence of commercial titania, Degussa P-25.	copolymer	23-32	tubulin polymerization promoting protein	Homo sapiens	174-178
18546169-4	2008	We developed a fluorescence-labeled conformation-sensitive CE method to quantitatively analyze PCR products covering the variable position in the SMN1/SMN2 genes using a copolymer solution composed of hydroxyethylcellulose and hydroxypropylcellulose.	copolymer	170-179	survival of motor neuron 1, telomeric	Homo sapiens	146-150
18380467-0	2008	P-glycoprotein efflux inhibition by amphiphilic diblock copolymers: relationship between copolymer concentration and substrate hydrophobicity.	copolymer	56-65	ATP binding cassette subfamily B member 1	Homo sapiens	0-14
18452324-1	2008	The salt effect on the complex formation of poly(acrylamide)- block-poly(sodium acrylate) (PAM- b-PAA) as a neutral-anionic block copolymer and dodecyltrimethylammonium bromide (DTAB) as a cationic surfactant at different NaBr concentrations, CNaBr, was investigated by turbidimetric titration, steady-state fluorescence spectroscopy, and dynamic light scattering.	copolymer	130-139	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	91-94
17896776-4	2008	On the blends of copolymers with PEO blocks of MW 2000 and 5000, fibrinogen adsorption from physiologic buffer decreased with increasing copolymer content up to 20 wt%.	copolymer	17-26	fibrinogen beta chain	Homo sapiens	65-75
17896776-8	2008	At low copolymer content (< or =10 wt %), fibrinogen adsorption decreased with decreasing PEO block length.	copolymer	7-16	fibrinogen beta chain	Homo sapiens	45-55
18359035-3	2008	It was speculated from angular dependence on dynamic light scattering (DLS) that the brush-on-brush copolymer (BB1:PSTM brushes were grafted at regular intervals of 1/4 styrene units on the backbone) with large aspect ratio took a geometrical anisotropic conformation such as a cylinder due to crowding of brush side chains.	copolymer	100-109	neuromedin B receptor	Homo sapiens	111-114
18242899-1	2008	The aim of this work was to investigate the effects of pluronic F68 block copolymer on the P-gp-mediated transport of celiprolol (CEL) and CYP3A4-mediated formation of midazolam (MDZ) metabolite 1"-hydroxymidazolam.	copolymer	74-83	phosphoglycolate phosphatase	Homo sapiens	91-95
18242899-1	2008	The aim of this work was to investigate the effects of pluronic F68 block copolymer on the P-gp-mediated transport of celiprolol (CEL) and CYP3A4-mediated formation of midazolam (MDZ) metabolite 1"-hydroxymidazolam.	copolymer	74-83	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	139-145
18246570-0	2008	Injectable and sustained delivery of human growth hormone using chemically modified Pluronic copolymer hydrogels.	copolymer	93-102	growth hormone 1	Homo sapiens	43-57
18307308-3	2008	It is shown that the copolymer B with 0.1 mol fraction CAB provides optimum hydrophilic liphophilic balance to form the most compact structures contributing to a surface area of 35.75 A(2)/molecule.	copolymer	21-30	neural proliferation, differentiation and control 1	Homo sapiens	55-58
18384691-9	2008	Dose-response experiments using the CG-PEI2K-PEG5K copolymer with total ESO ranging from 3-60 microg yielded a maximum of about 15% dystrophin expression.	copolymer	51-60	dystrophin, muscular dystrophy	Mus musculus	132-142
18029122-1	2008	The synergism in anticancer effect toward human renal carcinoma A498 cells by binary combinations of free and N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-bound anticancer drugs, SOS thiophene (SOS), doxorubicin (DOX), and mesochlorin e6 monoethylenediamine (Mce6), was evaluated.	copolymer	151-160	xylosyltransferase 2	Homo sapiens	185-188
18234330-1	2008	Very elastic poly(L-lactide-co-epsilon-caprolactone) (PLCL) (50:50) copolymer blended with gelatin was electrospun into microfibers from a hexafluoroisopropanol solution.	copolymer	68-77	phospholipase C-like 1	Mus musculus	54-58
18341422-3	2008	We have examined a new approach of delivering plasmid encoding mouse EPO cDNA into mouse skeletal muscle, using an amphiphilic block copolymer.	copolymer	133-142	erythropoietin	Mus musculus	69-72
18341422-6	2008	We conclude that repeated injections of low doses of block copolymer-DNA formulations that do not induce (1) inflammation at the injection site, (2) overexpression of EPO, or (3) the production of anti-EPO neutralizing auto-antibodies hold promise for in vivo expression of therapeutic proteins, in particular for systemic delivery.	copolymer	59-68	erythropoietin	Mus musculus	202-205
17972259-4	2008	The galactose moieties in the copolymer could be recognized by the ASGP-R of the hepatocytes through a receptor-mediated mechanism.	copolymer	30-39	mucin 4, cell surface associated	Homo sapiens	67-71
18029122-1	2008	The synergism in anticancer effect toward human renal carcinoma A498 cells by binary combinations of free and N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-bound anticancer drugs, SOS thiophene (SOS), doxorubicin (DOX), and mesochlorin e6 monoethylenediamine (Mce6), was evaluated.	copolymer	151-160	xylosyltransferase 2	Homo sapiens	200-203
18081338-3	2008	Random copolymers displayed an interaction similar to that observed with other hydrophilic homopolymers with the additional characteristic that the intensity of the interaction increased with the increase in the copolymer hydrophobicity (as determined by its PO content), revealing that these copolymers display an intermediate behavior between PEO and PPO.	copolymer	7-16	protoporphyrinogen oxidase	Homo sapiens	353-356
17881311-1	2008	In this work, the self-assembly of a recombinant elastin-based block copolymer containing both hydrophobic and cross-linking domains from the human elastin protein was investigated.	copolymer	69-78	elastin	Homo sapiens	49-56
17935731-2	2008	In acidic solution, this copolymer forms core-shell micelles with the neutral PMAA chains being located in the hydrophobic cores and the protonated PDEA chains forming the cationic micelle coronas.	copolymer	25-34	phosphodiesterase 6A	Homo sapiens	148-152
17935731-3	2008	In alkaline solution, the copolymer forms the analogous inverted micelles with anionic PMAA coronas and hydrophobic PDEA cores.	copolymer	26-35	phosphodiesterase 6A	Homo sapiens	116-120
17881311-1	2008	In this work, the self-assembly of a recombinant elastin-based block copolymer containing both hydrophobic and cross-linking domains from the human elastin protein was investigated.	copolymer	69-78	elastin	Homo sapiens	148-155
18607107-1	2008	BACKGROUND: Copaxone (glatiramer acetate) is a synthetic copolymer mimicking a portion of myelin basic protein, one of several putative autoantigens in multiple sclerosis (MS).	copolymer	57-66	myelin basic protein	Homo sapiens	90-110
18163573-7	2008	These results suggest that the mechanical properties of ELP hydrogels and the microenvironment that they present to cells can be tuned by the design of the block copolymer architecture.	copolymer	162-171	nuclear receptor subfamily 5 group A member 1	Homo sapiens	56-59
19206545-7	2008	Furthermore, at 4 nm thick per layer, orders of magnitude thinner than conventional drug delivery coatings, these dexamethasone-copolymer mixtures (PolyDex) suppressed in vitro expression of the inflammatory cytokines/signaling elements interleukin 6 (IL-6), interleukin 12 (IL-12), tumor necrosis factor alpha (TNFalpha), inducible nitric oxide synthase (iNOS), and interferon gamma inducible protein (IP-10).	copolymer	128-137	interleukin 6	Homo sapiens	237-250
19206545-7	2008	Furthermore, at 4 nm thick per layer, orders of magnitude thinner than conventional drug delivery coatings, these dexamethasone-copolymer mixtures (PolyDex) suppressed in vitro expression of the inflammatory cytokines/signaling elements interleukin 6 (IL-6), interleukin 12 (IL-12), tumor necrosis factor alpha (TNFalpha), inducible nitric oxide synthase (iNOS), and interferon gamma inducible protein (IP-10).	copolymer	128-137	interleukin 6	Homo sapiens	252-256
19206545-7	2008	Furthermore, at 4 nm thick per layer, orders of magnitude thinner than conventional drug delivery coatings, these dexamethasone-copolymer mixtures (PolyDex) suppressed in vitro expression of the inflammatory cytokines/signaling elements interleukin 6 (IL-6), interleukin 12 (IL-12), tumor necrosis factor alpha (TNFalpha), inducible nitric oxide synthase (iNOS), and interferon gamma inducible protein (IP-10).	copolymer	128-137	tumor necrosis factor	Homo sapiens	283-310
19206545-7	2008	Furthermore, at 4 nm thick per layer, orders of magnitude thinner than conventional drug delivery coatings, these dexamethasone-copolymer mixtures (PolyDex) suppressed in vitro expression of the inflammatory cytokines/signaling elements interleukin 6 (IL-6), interleukin 12 (IL-12), tumor necrosis factor alpha (TNFalpha), inducible nitric oxide synthase (iNOS), and interferon gamma inducible protein (IP-10).	copolymer	128-137	tumor necrosis factor	Homo sapiens	312-320
19206545-7	2008	Furthermore, at 4 nm thick per layer, orders of magnitude thinner than conventional drug delivery coatings, these dexamethasone-copolymer mixtures (PolyDex) suppressed in vitro expression of the inflammatory cytokines/signaling elements interleukin 6 (IL-6), interleukin 12 (IL-12), tumor necrosis factor alpha (TNFalpha), inducible nitric oxide synthase (iNOS), and interferon gamma inducible protein (IP-10).	copolymer	128-137	nitric oxide synthase 2	Homo sapiens	323-354
19206545-7	2008	Furthermore, at 4 nm thick per layer, orders of magnitude thinner than conventional drug delivery coatings, these dexamethasone-copolymer mixtures (PolyDex) suppressed in vitro expression of the inflammatory cytokines/signaling elements interleukin 6 (IL-6), interleukin 12 (IL-12), tumor necrosis factor alpha (TNFalpha), inducible nitric oxide synthase (iNOS), and interferon gamma inducible protein (IP-10).	copolymer	128-137	nitric oxide synthase 2	Homo sapiens	356-360
19206545-7	2008	Furthermore, at 4 nm thick per layer, orders of magnitude thinner than conventional drug delivery coatings, these dexamethasone-copolymer mixtures (PolyDex) suppressed in vitro expression of the inflammatory cytokines/signaling elements interleukin 6 (IL-6), interleukin 12 (IL-12), tumor necrosis factor alpha (TNFalpha), inducible nitric oxide synthase (iNOS), and interferon gamma inducible protein (IP-10).	copolymer	128-137	C-X-C motif chemokine ligand 10	Homo sapiens	367-408
17629639-7	2007	The insulin and BVP released from the copolymer hydrogel over 15 and 40 days, respectively.	copolymer	38-47	insulin	Homo sapiens	4-11
17607515-1	2008	A degradable copolymer of L-lactide and glycolide (PLG) was synthesized by ring opening polymerization using zirconium acetylacetonate [Zr(acac)(4)] as a biocompatible initiator.	copolymer	13-22	plasminogen	Homo sapiens	51-54
18271299-3	2008	The release of IL-2 from the copolymer-based hydrogel in the phosphate buffer (pH 7.2) was studied at 37 degrees C under agitation.	copolymer	29-38	interleukin 2	Mus musculus	15-19
18271299-4	2008	IL-2 was released from the copolymer-based hydrogels over 20 days in vitro and the release rate decreased with increasing copolymer concentration.	copolymer	27-36	interleukin 2	Mus musculus	0-4
18271299-4	2008	IL-2 was released from the copolymer-based hydrogels over 20 days in vitro and the release rate decreased with increasing copolymer concentration.	copolymer	122-131	interleukin 2	Mus musculus	0-4
18271299-7	2008	To evaluate the anti-tumor effect of the IL-2 loaded copolymer, solutions were injected subcutaneously to H22 tumor-bearing mice.	copolymer	53-62	interleukin 2	Mus musculus	41-45
18271299-8	2008	IL-2 loaded copolymer hydrogel for in vivo use showed good anti-tumor effect.	copolymer	12-21	interleukin 2	Mus musculus	0-4
17504736-5	2007	The copolymer films were coated with CAPs, such as collagen, fibronectin and laminin, to increase their cell adhesion and growth properties.	copolymer	4-13	fibronectin 1	Homo sapiens	61-72
17929850-0	2007	Location control of Au/CdS nanoparticles in block copolymer micelles.	copolymer	50-59	CDP-diacylglycerol synthase 1	Homo sapiens	23-26
17645358-2	2007	The complex pattern was generated spontaneously by spin coating and annealing a thin film of a lamellae-forming block copolymer on a chemically neutral surface.	copolymer	118-127	spindlin 1	Homo sapiens	51-55
17760417-3	2007	To preclude BMM-mediated enzyme degradation, catalase was packaged into a block ionomer complex with a cationic block copolymer, polyethyleneimine-poly(ethylene glycol) (PEI-PEG).	copolymer	118-127	catalase	Homo sapiens	45-53
17323321-2	2007	When the weight percent of both PCL and PEO blocks within copolymer was similar to each other, the maximal melting temperature, the crystallization temperature, degree of crystallinity, and the spherulitic growth rate of these copolymers decreased with the increasing arm number of polymer.	copolymer	58-67	twinkle mtDNA helicase	Homo sapiens	40-43
17867644-0	2007	Apoptotic epidermal growth factor (EGF)-conjugated block copolymer micelles as a nanotechnology platform for targeted combination therapy.	copolymer	57-66	epidermal growth factor	Homo sapiens	10-33
17867644-0	2007	Apoptotic epidermal growth factor (EGF)-conjugated block copolymer micelles as a nanotechnology platform for targeted combination therapy.	copolymer	57-66	epidermal growth factor	Homo sapiens	35-38
17867644-2	2007	In the present study, block copolymer micelles are conjugated with epidermal growth factor (EGF), which acts as both a targeting ligand for the drug carrier and an apoptotic factor against EGFR-overexpressing cancers.	copolymer	28-37	epidermal growth factor	Homo sapiens	67-90
17867644-2	2007	In the present study, block copolymer micelles are conjugated with epidermal growth factor (EGF), which acts as both a targeting ligand for the drug carrier and an apoptotic factor against EGFR-overexpressing cancers.	copolymer	28-37	epidermal growth factor	Homo sapiens	92-95
17867644-2	2007	In the present study, block copolymer micelles are conjugated with epidermal growth factor (EGF), which acts as both a targeting ligand for the drug carrier and an apoptotic factor against EGFR-overexpressing cancers.	copolymer	28-37	epidermal growth factor receptor	Homo sapiens	189-193
17636998-0	2007	Motion of integrated CdS nanoparticles by phase separation of block copolymer brushes.	copolymer	68-77	CDP-diacylglycerol synthase 1	Homo sapiens	21-24
17636998-1	2007	A new method of reversibly moving CdS nanoparticles in the perpendicular direction was developed on the basis of the phase separation of block copolymer brushes.	copolymer	143-152	CDP-diacylglycerol synthase 1	Homo sapiens	34-37
17645358-5	2007	Spin coating a second thin film of the block copolymer and annealing resulted in directed assembly that replicated the fingerprint pattern, including the most complicated defect structures.	copolymer	45-54	spindlin 1	Homo sapiens	0-4
17550288-0	2007	Lipase-catalyzed copolymerization of omega-pentadecalactone with p-dioxanone and characterization of copolymer thermal and crystalline properties.	copolymer	17-26	PAN0_003d1715	Moesziomyces antarcticus	0-6
17676050-1	2007	Treatment with glatiramer acetate (GA, copolymer-1, Copaxone), a drug approved for multiple sclerosis (MS), in a mouse model promoted development of anti-inflammatory type II monocytes, characterized by increased secretion of interleukin (IL)-10 and transforming growth factor (TGF)-beta, and decreased production of IL-12 and tumor necrosis factor (TNF).	copolymer	39-48	interleukin 10	Mus musculus	226-245
17485668-4	2007	We show that nanoparticles (copolymer particles, cerium oxide particles, quantum dots, and carbon nanotubes) enhance the probability of appearance of a critical nucleus for nucleation of protein fibrils from human beta(2)-microglobulin.	copolymer	28-37	beta-2-microglobulin	Homo sapiens	214-235
17439172-3	2007	Such interactions influence the self-assembly properties of the block copolymer in solution by increasing the hydration of the block copolymers and stabilizing the gauche conformation of the PPO chain.	copolymer	70-79	protoporphyrinogen oxidase	Homo sapiens	191-194
17315976-1	2007	We synthesized a novel arginine-grafted dendritic block copolymer, R-PAMAM-PEG-PAMAM-R G5 (PPP5-R) for gene delivery systems.	copolymer	56-65	protein phosphatase 5 catalytic subunit	Homo sapiens	91-95
17379348-6	2007	The copolymer containing 27.5 mole% of the comonomer with the C(6) moiety, which was chosen for further study, has the CT 22 degrees C and its phase separation is complete at 34 degrees C. Polymer dissolution is complete within 48 h at both pH 5.0 or 7.4.	copolymer	4-13	sperm autoantigenic protein 17	Homo sapiens	119-124
16969827-0	2007	A biodegradable copolymer for the slow release of growth hormone expedites scarring in diabetic rats.	copolymer	16-25	gonadotropin releasing hormone receptor	Rattus norvegicus	50-64
17371065-3	2007	DSC analysis of the copolymer indicates well-defined crystallization and melting transitions different from the homopolymers and corresponding blend.	copolymer	20-29	desmocollin 3	Homo sapiens	0-3
19300558-2	2007	It consists of a copolymer of amino acid residues in the same stoichiometric proportions as in myelin basic protein.	copolymer	17-26	myelin basic protein	Homo sapiens	95-115
17487614-5	2007	Similarly the Mv of the copolymer was determined with the (eta) data of lysozyme (molecular weight=24,000 g mol(-1)), egg albumin(40,000 g mol (-1)) and BSA (65,000 g mol (-1)).	copolymer	24-33	endothelin receptor type A	Homo sapiens	59-62
17218007-4	2007	The electrical conductivity of the PAP2 copolymer film ( approximately 5x10(-6)S/cm) is in the semiconducting region.	copolymer	40-49	phospholipid phosphatase 1	Homo sapiens	35-39
17289216-6	2007	A copolymer conjugate of GnRH-III showed 2-3-fold anticancer activity while losing endocrine potency.	copolymer	2-11	gonadotropin releasing hormone 1	Homo sapiens	25-29
17196698-1	2007	Heparin conjugated amphiphilic block copolymer, Tetronic-PCL-heparin (TCH), was developed and its polymeric micelles (PMs) were prepared as an injectable vehicle for long-term delivery of bFGF, which is one of the heparin-binding growth factors (HBGF).	copolymer	37-46	fibroblast growth factor 2	Homo sapiens	188-192
16930613-1	2006	The pH-responsive behavior of adsorbed diblock copolymer films of PDMA-PDEA (poly(2-(dimethylamino)ethyl methacrylate)-block-poly(2-(diethylamino)ethyl methacrylate)) on silica has been characterized using a quartz crystal microbalance with dissipation monitoring (QCM-D), an optical reflectometer (OR) and an atomic force microscope (AFM).	copolymer	47-56	phosphodiesterase 6A	Homo sapiens	66-75
17241021-2	2007	Well-defined double hydrophilic miktoarm AB4 star copolymer, PNIPAM-b-(PDEA)4, was then synthesized by polymerizing 2-(diethylamino)ethyl methacrylate (DEA) via ATRP in 2-propanol at 45 degrees C using 1b, where PDEA was poly(2-(diethylamino)ethyl methacrylate).	copolymer	50-59	phosphodiesterase 6A	Homo sapiens	71-75
17241021-2	2007	Well-defined double hydrophilic miktoarm AB4 star copolymer, PNIPAM-b-(PDEA)4, was then synthesized by polymerizing 2-(diethylamino)ethyl methacrylate (DEA) via ATRP in 2-propanol at 45 degrees C using 1b, where PDEA was poly(2-(diethylamino)ethyl methacrylate).	copolymer	50-59	phosphodiesterase 6A	Homo sapiens	212-216
17579269-7	2007	The Gb3 copolymer with high sugar unit density showed stronger neutralizing activity against Stx-2 than those with lower density.	copolymer	8-17	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	4-7
17579269-7	2007	The Gb3 copolymer with high sugar unit density showed stronger neutralizing activity against Stx-2 than those with lower density.	copolymer	8-17	syntaxin 2	Homo sapiens	93-98
17579269-9	2007	Intravenous administration of the Gb3 copolymer prevented death in mice lethally infected with Stx-1- and Stx-2-producing E. coli O157:H7.	copolymer	38-47	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	34-37
17579269-9	2007	Intravenous administration of the Gb3 copolymer prevented death in mice lethally infected with Stx-1- and Stx-2-producing E. coli O157:H7.	copolymer	38-47	syntaxin 1A	Homo sapiens	95-100
17579269-9	2007	Intravenous administration of the Gb3 copolymer prevented death in mice lethally infected with Stx-1- and Stx-2-producing E. coli O157:H7.	copolymer	38-47	syntaxin 2	Mus musculus	106-111
17579269-10	2007	Thus, we demonstrated that the artificial Gb3 copolymer could neutralize Stx-1 and the more clinically relevant Stx-2 in vitro and effectively inhibit Stx toxicity in vivo.	copolymer	46-55	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	42-45
17579269-10	2007	Thus, we demonstrated that the artificial Gb3 copolymer could neutralize Stx-1 and the more clinically relevant Stx-2 in vitro and effectively inhibit Stx toxicity in vivo.	copolymer	46-55	syntaxin 1A	Homo sapiens	73-78
17579269-10	2007	Thus, we demonstrated that the artificial Gb3 copolymer could neutralize Stx-1 and the more clinically relevant Stx-2 in vitro and effectively inhibit Stx toxicity in vivo.	copolymer	46-55	syntaxin 2	Homo sapiens	112-117
17531858-1	2007	Glatiramer acetate (GA), formerly known as copolymer 1, is a mixture of synthetic polypeptides composed of four amino acids resembling the myelin basic protein (MSP).	copolymer	43-52	myelin basic protein	Homo sapiens	139-159
17022991-6	2006	The TGA revealed that the thermal property of the copolymer enhanced due to the interaction of the nanoparticles and the groups of the copolymer.	copolymer	50-59	T-box transcription factor 1	Homo sapiens	4-7
17022991-6	2006	The TGA revealed that the thermal property of the copolymer enhanced due to the interaction of the nanoparticles and the groups of the copolymer.	copolymer	135-144	T-box transcription factor 1	Homo sapiens	4-7
17192974-0	2006	Dip-pen nanolithography on (bio)reactive monolayer and block-copolymer platforms: deposition of lines of single macromolecules.	copolymer	61-70	DIP	Homo sapiens	0-3
17073495-3	2006	The rates of HAP crystal growth on the polymeric substrate were found to depend on the amount of seed material and on the phosphate content of the copolymer.	copolymer	147-156	reticulon 3	Homo sapiens	13-16
17073500-0	2006	Effect of hydrophobicity inside PEO-PPO-PEO block copolymer micelles on the stabilization of gold nanoparticles: experiments.	copolymer	50-59	protoporphyrinogen oxidase	Homo sapiens	36-39
17025363-6	2006	The high molar mass of this copolymer was confirmed both by (1)H NMR and SANS measurements.	copolymer	28-37	USH1 protein network component sans	Homo sapiens	73-77
17028038-5	2006	In this study, PHEA was firstly functionalised with ethylendiamine, obtaining a well defined copolymer with pendant primary amine groups (PHEA-EDA), to which N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP) and 3-(carboxypropyl)trimethyl-ammonium chloride (CPTA) were linked in two subsequent steps, allowing the introduction of thiol and cationic groups respectively.	copolymer	93-102	ectodysplasin A	Homo sapiens	143-146
16869582-4	2006	As a result, the adsorption behavior of PDMA-PDEA diblock copolymers on silica is strongly dependent on both the copolymer concentration and the solution pH.	copolymer	58-67	phosphodiesterase 6A	Homo sapiens	45-49
16716343-1	2006	The copolymer of beta-casein-graft-dextran was prepared using the Maillard reaction and the acidic solution properties of the copolymer were studied with dynamic light scattering.	copolymer	4-13	casein beta	Homo sapiens	17-28
16716343-2	2006	At pH range 4-5 where is close to the isoelectric point of beta-casein, the copolymer forms micelles which are spherical verified by atomic force microscopy imaging.	copolymer	76-85	casein beta	Homo sapiens	59-70
16734388-6	2006	The aim of this study was to determine if delivery of vascular endothelial growth factor (VEGF) from a biodegradable PLGA (copolymer of D,L-lactide and glycolide) scaffold could enhance neovascularization and bone regeneration in irradiated osseous defects.	copolymer	123-132	vascular endothelial growth factor A	Rattus norvegicus	54-88
16834355-0	2006	Diblock copolymer micellar nanoparticles decorated with annexin-A5 proteins.	copolymer	8-17	annexin A5	Homo sapiens	56-66
16800514-3	2006	By systematically varying the volume fractions of block A, B, and C, the triangle phase diagrams of the H-shaped ABC block copolymer with equal interactions among the three species are constructed.	copolymer	123-132	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	113-116
17092842-5	2006	Incubation of the PGE1-containing macromonomer and HPMA copolymer-PGE1 conjugates with cathepsin K resulted in release of unmodified PGE1.	copolymer	56-65	cathepsin K	Homo sapiens	87-98
16734388-6	2006	The aim of this study was to determine if delivery of vascular endothelial growth factor (VEGF) from a biodegradable PLGA (copolymer of D,L-lactide and glycolide) scaffold could enhance neovascularization and bone regeneration in irradiated osseous defects.	copolymer	123-132	vascular endothelial growth factor A	Rattus norvegicus	90-94
16608409-8	2006	Copolymer 1 (Cop 1, glatiramer acetate, Copaxone) is a synthetic amino acid random copolymer that is immunologically cross-reactive with myelin basic protein and suppresses experimental allergic encephalomyelitis in several animal species.	copolymer	0-9	myelin basic protein	Homo sapiens	137-157
16749867-9	2006	HPMA copolymer-bound doxorubicin induced a time-dependent decrease in the expression of the anti-apoptotic Bcl-2 and Bcl-xL proteins, which control cell survival.	copolymer	5-14	BCL2 apoptosis regulator	Homo sapiens	107-112
16749867-9	2006	HPMA copolymer-bound doxorubicin induced a time-dependent decrease in the expression of the anti-apoptotic Bcl-2 and Bcl-xL proteins, which control cell survival.	copolymer	5-14	BCL2 like 1	Homo sapiens	117-123
16602731-2	2006	This work was thus triggered to synthesize poly(lactide)/Tween 80 copolymers with various copolymer blend ratio, which were synthesized by ring-opening polymerization and characterized by 1H NMR and TGA.	copolymer	66-75	T-box transcription factor 1	Homo sapiens	199-202
16608409-8	2006	Copolymer 1 (Cop 1, glatiramer acetate, Copaxone) is a synthetic amino acid random copolymer that is immunologically cross-reactive with myelin basic protein and suppresses experimental allergic encephalomyelitis in several animal species.	copolymer	83-92	myelin basic protein	Homo sapiens	137-157
16536472-13	2006	These results demonstrate that the EGF-conjugated copolymer micelles developed in this study have potential as vehicles for targeting hydrophobic drugs to EGFR-overexpressing cancers.	copolymer	50-59	epidermal growth factor receptor	Homo sapiens	155-159
16054638-0	2006	Electrorheological properties of PMMA-b-PSt copolymer suspensions.	copolymer	44-53	sulfotransferase family 1A member 1	Homo sapiens	40-43
16468918-1	2006	The phase behavior of AfmN(BN2AN2)B(1-fmN) multiblock copolymer melts is studied within the weak segregation theory.	copolymer	54-63	formin 1	Homo sapiens	23-26
16242925-1	2005	The graft copolymer (APN) of alginate and poly(N-isopropylacrylamide) (PNIPAM) were synthesized and APN beads were prepared by dropping the aqueous solution of the copolymer into an aqueous solution of Ca(2+) solution.	copolymer	10-19	alanyl aminopeptidase, membrane	Homo sapiens	21-24
16226711-10	2005	The relative increases of fluorescence intensity at 390nm were 14%, 46%, and 77% for the copolymer filaments with the CP24 to actin molar ratios of 0.0625, 0.143, and 0.333, respectively, and demonstrated a sigmoid behavior.	copolymer	89-98	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	118-122
16023714-2	2005	Matrices were obtained by functionalization of a four-arm PEO-PPO block copolymer (poloxamine, Tetronic) with methcrylate groups and subsequent free radical polymerization of water solutions of the modified polymer in the presence of collagen.	copolymer	72-81	protoporphyrinogen oxidase	Homo sapiens	62-65
16242925-1	2005	The graft copolymer (APN) of alginate and poly(N-isopropylacrylamide) (PNIPAM) were synthesized and APN beads were prepared by dropping the aqueous solution of the copolymer into an aqueous solution of Ca(2+) solution.	copolymer	164-173	alanyl aminopeptidase, membrane	Homo sapiens	21-24
16285826-2	2005	An amphiphilic copolymer, poly(L-leucine) grafted polyallylamine as a simple model of proteins, has been prepared by NCA polymerization with free amino groups of polyallylamine as an initiator.	copolymer	15-24	CEA cell adhesion molecule 6	Homo sapiens	117-120
16242925-1	2005	The graft copolymer (APN) of alginate and poly(N-isopropylacrylamide) (PNIPAM) were synthesized and APN beads were prepared by dropping the aqueous solution of the copolymer into an aqueous solution of Ca(2+) solution.	copolymer	164-173	alanyl aminopeptidase, membrane	Homo sapiens	100-103
16283753-4	2005	FN bound poorly to PEMUs terminated with a copolymer of poly(acrylic acid) (PAA) and 3-[2-(acrylamido)-ethyl dimethylammonio] propane sulfonate (PAA-co-AEDAPS).	copolymer	43-52	fibronectin 1	Rattus norvegicus	0-2
16853727-2	2005	Polydispersity of the end or middle blocks in the ABC linear block copolymer chains results in a completely different phase diagram.	copolymer	67-76	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	50-53
16283726-8	2005	The structure of the block copolymer was confirmed by 1H NMR, IR, and GPC.	copolymer	27-36	glycophorin C (Gerbich blood group)	Homo sapiens	70-73
15976190-5	2005	The retinal neurons could be protected from these effects by vaccination, 7 days before or immediately after intoxication, with the copolymer glatiramer acetate (Cop-1), recently found to limit the usual consequences of an acute glutamate insult to the eye.	copolymer	132-141	COP1, E3 ubiquitin ligase	Mus musculus	162-167
16059894-1	2005	Four-arm poly(ethylene oxide) and poly(propylene oxide) (PEO-PPO) block copolymer (poloxamine, Tetronic 1107) hydrogels were modified with positively charged groups with the aim of overcoming the low cell adhesion properties of these PEO-rich systems.	copolymer	72-81	protoporphyrinogen oxidase	Homo sapiens	61-64
16096740-4	2005	We previously demonstrated effective T-cell-based neuroprotection in experimental animals vaccinated with the synthetic copolymer glatiramer acetate (copolymer-1, Cop-1), a weak agonist of self-antigens.	copolymer	120-129	COP1, E3 ubiquitin ligase	Rattus norvegicus	163-168
15792541-1	2005	Recombinant human bone morphogenetic protein (rhBMP)-2 in a block copolymer composed of poly-D,L-lactic acid with randomly inserted p-dioxanone and polyethylene glycol (PLA-DX-PEG) as a carrier and porous beta-tricalcium phosphate (beta-TCP) blocks were used to generate a new fully absorbable osteogenic biomaterial.	copolymer	66-75	bone morphogenetic protein 1	Homo sapiens	18-44
16100572-4	2005	Here we show that nasal vaccination with a proteosome-based adjuvant that is well tolerated in humans plus glatiramer acetate, an FDA-approved synthetic copolymer used to treat multiple sclerosis, potently decreases Abeta plaques in an AD mouse model.	copolymer	153-162	amyloid beta precursor protein	Homo sapiens	216-221
16090186-1	2005	Starlike PEP-PEO block copolymer micelles offer the possibility to investigate the phase behavior and interactions of regular star polymers (ultrasoft colloids).	copolymer	23-32	progestagen associated endometrial protein	Homo sapiens	9-12
16096992-7	2005	The microspheres fabricated from the copolymer with dCPS content as low as 10% could be clearly visualized with fluorescence microscopy.	copolymer	37-46	rudimentary	Drosophila melanogaster	52-56
15910751-3	2005	The MgATPase rate of CP24-skeletal actin copolymer was 1.06 s(-1), which is slightly less than the V(max) of Dictyostelium S1.	copolymer	41-50	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	21-25
16701825-7	2005	Higher degrees of thrombin binding were observed for substrates configured with the hydrophilic compared to the more hydrophobic copolymer.	copolymer	129-138	coagulation factor II, thrombin	Homo sapiens	18-26
16701825-9	2005	Altogether, the choice of copolymer coatings and the type of PEG spacers were demonstrated to enhance the efficiency of the thrombin scavenging by the covalently immobilized coagulation inhibitor.	copolymer	26-35	coagulation factor II, thrombin	Homo sapiens	124-132
15741092-4	2005	In this research, a MIP was formed for theophylline using a copolymer of methacrylic acid and ethylene glycol dimethacrylate.	copolymer	60-69	major intrinsic protein of lens fiber	Homo sapiens	20-23
16851902-6	2005	In step 2, the adsorption of block copolymers on the surface of gold clusters takes place because of the amphiphilic character of the block copolymer (hydrophobicity of PPO).	copolymer	35-44	protoporphyrinogen oxidase	Homo sapiens	169-172
16851902-7	2005	The much higher efficiency of particle formation attained in the PEO-PPO-PEO block copolymer systems as compared to PEO homopolymer systems can be attributed to the adsorption and growth processes (steps 2 and 3) facilitated by the block copolymers.	copolymer	83-92	protoporphyrinogen oxidase	Homo sapiens	69-72
15877363-3	2005	At 20 degrees C, the block copolymer is associated into micelles with a hydrodynamic radius of 11.6 nm, which is composed of a hydrophobic styrene oxide (S) core and a water-swollen oxypolyethylene (PEO or E) corona.	copolymer	27-36	twinkle mtDNA helicase	Homo sapiens	199-207
15940599-0	2005	Fixation of the chevron osteotomy with an absorbable copolymer pin for treatment of hallux valgus deformity.	copolymer	53-62	dynein light chain LC8-type 1	Homo sapiens	63-66
15940599-1	2005	This study investigated the use of a bioabsorbable pin made of an oriented poly-L-lactic acid/polyglycolic acid (82:18 ratio) copolymer to fix distal chevron osteotomies in 15 patients (18 feet), with an average follow-up of 18 months.	copolymer	126-135	dynein light chain LC8-type 1	Homo sapiens	51-54
15783172-1	2005	An analysis of the loading rate dependence of the forces required to rupture an AFM tip from a block copolymer surface has provided insight into the structure of the surface-macromolecule contact, differentiation of the block contacting the tip, a measure of the polymer-surface binding energy, and the rigidity of the contact.	copolymer	101-110	afamin	Homo sapiens	80-83
15752806-0	2005	Effect of drying on the mesoporous structure of sol-gel derived silica with PPO-PEO-PPO template block copolymer.	copolymer	103-112	protoporphyrinogen oxidase	Homo sapiens	76-79
15752806-0	2005	Effect of drying on the mesoporous structure of sol-gel derived silica with PPO-PEO-PPO template block copolymer.	copolymer	103-112	protoporphyrinogen oxidase	Homo sapiens	84-87
16036307-3	2005	The purpose of this study is to investigate the potential of water-soluble N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-doxorubicin (Dox) conjugates containing a Hsp47/CBP2 binding peptide sequence, namely WHYPWFQNWAMA for targeted delivery to SCCHN.	copolymer	116-125	serpin family H member 1	Homo sapiens	168-173
16036307-3	2005	The purpose of this study is to investigate the potential of water-soluble N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-doxorubicin (Dox) conjugates containing a Hsp47/CBP2 binding peptide sequence, namely WHYPWFQNWAMA for targeted delivery to SCCHN.	copolymer	116-125	serpin family H member 1	Homo sapiens	174-178
15783172-1	2005	An analysis of the loading rate dependence of the forces required to rupture an AFM tip from a block copolymer surface has provided insight into the structure of the surface-macromolecule contact, differentiation of the block contacting the tip, a measure of the polymer-surface binding energy, and the rigidity of the contact.	copolymer	101-110	TOR signaling pathway regulator	Homo sapiens	84-87
15625681-0	2005	Fibronectin adsorption and arrangement on copolymer surfaces and their significance in cell adhesion.	copolymer	42-51	fibronectin 1	Mus musculus	0-11
15771520-3	2005	The existence of a graft copolymer between the PA6 chains and the SWNTs is demonstrated by IR, TGA, and AFM studies, and we show that the solubility of the polymerized material in formic acid is controlled by the degree of graft copolymerization.	copolymer	25-34	T-box transcription factor 1	Homo sapiens	95-98
16851102-4	2005	The expressions allow one to quantitatively describe high-resolution synchrotron small-angle X-ray (SAXS) and neutron scattering (SANS) curves from lipid and block copolymer lyotropic phases, core/shell nanoparticle superstructures, ordered nanocomposites, and ordered mesoporous materials.	copolymer	164-173	USH1 protein network component sans	Homo sapiens	130-134
15625681-1	2005	The adsorption of fibronectin (FN) to (styrene/methyl methacrylate) copolymer surfaces, both sulfonated (hydrophilic) and nonsulfonated (hydrophobic), was studied by means of the radioisotope (125I-FN) and ELISA assays; the latter employed monoclonal antibodies.	copolymer	68-77	fibronectin 1	Mus musculus	18-29
15625681-1	2005	The adsorption of fibronectin (FN) to (styrene/methyl methacrylate) copolymer surfaces, both sulfonated (hydrophilic) and nonsulfonated (hydrophobic), was studied by means of the radioisotope (125I-FN) and ELISA assays; the latter employed monoclonal antibodies.	copolymer	68-77	fibronectin 1	Mus musculus	31-33
15595812-6	2004	It is also shown that Cd2+ activation of photoluminescence does not occur when Mg2+ ions are added to similar QD solutions, indicating potential of these block copolymer-stabilized QDs as Cd2+-selective sensors.	copolymer	160-169	CD2 molecule	Homo sapiens	22-25
15592689-1	2005	In this paper, we have investigated the lower critical solution temperature (LCST) of N-isopropylacrylamide-acrylic acid (NIPAAm-AAc) copolymer as a function of chain-transfer agent/initiator mole ratio, acrylic acid content of copolymer, concentration, pH and ionic strength of aqueous copolymer solution.	copolymer	134-143	glycine-N-acyltransferase	Homo sapiens	129-132
15578422-9	2005	The CD4+/CD8+ ratio was low during the initial follow up stages (3 and 7 days) in untreated diabetic rats, yet an increased ratio corresponding to areas around the polymer remains was noted in the animals treated with copolymer loaded with the growth hormone.	copolymer	218-227	gonadotropin releasing hormone receptor	Rattus norvegicus	244-258
15595812-6	2004	It is also shown that Cd2+ activation of photoluminescence does not occur when Mg2+ ions are added to similar QD solutions, indicating potential of these block copolymer-stabilized QDs as Cd2+-selective sensors.	copolymer	160-169	CD2 molecule	Homo sapiens	188-191
15571354-3	2004	In one method, the epoxy groups of this copolymer were used directly for the immobilization of HSA through its amine residues (i.e., the epoxy method); in other approaches, these epoxy groups were converted to diols for later use in the carbonyldiimidazole, disuccinimidyl carbonate, and Schiff base methods.	copolymer	40-49	albumin	Homo sapiens	95-98
15476793-0	2004	Micellization of block copolymer P94 in aqueous solution.	copolymer	23-32	calpain 3	Homo sapiens	33-36
15549735-4	2004	Vaccination with retina-derived antigens or with the synthetic copolymer glatiramer acetate (Copolymer-1, Cop-1), but not with beta-amyloid, reduced the ocular neuronal loss.	copolymer	63-72	COP1, E3 ubiquitin ligase	Mus musculus	106-111
15530067-3	2004	Therefore, we introduced PEG to engineer a nontoxic and highly transfection efficient polymeric gene carrier because PEG is known to convey water-solubility and biocompatibility to the conjugated copolymer.	copolymer	196-205	progestagen associated endometrial protein	Homo sapiens	25-28
15508046-2	2004	Tyrosinase was first immobilised by entrapping it in a copolymer membrane of poly(vinyl alcohol)-hydroxyethyl carboxymethylcellulose doped with octadecylsilica particles.	copolymer	55-64	tyrosinase	Homo sapiens	0-10
15648254-8	2004	CONCLUSIONS: These data suggest that there are unifying pathways for the inhibition of Pgp and MRPs by the block copolymer.	copolymer	113-122	phosphoglycolate phosphatase	Homo sapiens	87-90
15530067-3	2004	Therefore, we introduced PEG to engineer a nontoxic and highly transfection efficient polymeric gene carrier because PEG is known to convey water-solubility and biocompatibility to the conjugated copolymer.	copolymer	196-205	progestagen associated endometrial protein	Homo sapiens	117-120
15530067-6	2004	Consequently, these data show that an approach involving the introduction of PEG to create a tree-like cationic copolymer possesses a great potential for use in gene delivery systems.	copolymer	112-121	progestagen associated endometrial protein	Homo sapiens	77-80
15587920-1	2004	PURPOSE: The amphiphilic block copolymer Pluronic P85 (P85) increases the permeability of the blood-brain barrier (BBB) with respect to a broad spectrum of drugs by inhibiting the drug efflux transporter, P-glycoprotein (Pgp).	copolymer	31-40	extracellular matrix protein 1	Mus musculus	50-53
15587920-1	2004	PURPOSE: The amphiphilic block copolymer Pluronic P85 (P85) increases the permeability of the blood-brain barrier (BBB) with respect to a broad spectrum of drugs by inhibiting the drug efflux transporter, P-glycoprotein (Pgp).	copolymer	31-40	extracellular matrix protein 1	Mus musculus	55-58
15587920-1	2004	PURPOSE: The amphiphilic block copolymer Pluronic P85 (P85) increases the permeability of the blood-brain barrier (BBB) with respect to a broad spectrum of drugs by inhibiting the drug efflux transporter, P-glycoprotein (Pgp).	copolymer	31-40	phosphoglycolate phosphatase	Mus musculus	205-219
15450816-0	2004	Affinity depletion of albumin from human cerebrospinal fluid using Cibacron-blue-3G-A-derivatized photopatterned copolymer in a microfluidic device.	copolymer	113-122	albumin	Homo sapiens	22-29
15587920-1	2004	PURPOSE: The amphiphilic block copolymer Pluronic P85 (P85) increases the permeability of the blood-brain barrier (BBB) with respect to a broad spectrum of drugs by inhibiting the drug efflux transporter, P-glycoprotein (Pgp).	copolymer	31-40	phosphoglycolate phosphatase	Mus musculus	221-224
15490442-5	2004	Here we describe a new approach to induce a directed insertion of membrane proteins into asymmetric membranes formed by amphiphilic ABC triblock copolymers with two chemically different water-soluble blocks A and C. In a comparative study we have reconstituted His-tag labeled Aquaporin 0 in lipid, ABA block copolymer, and ABC block copolymer vesicles.	copolymer	145-154	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	132-135
15308777-3	2004	Copolymer 1 (Cop 1, glatiramer acetate, Copaxone) is a synthetic amino acid random copolymer, immunologically cross-reactive with myelin basic protein and suppresses experimental allergic encephalomyelitis in several animal species.	copolymer	0-9	myelin basic protein	Homo sapiens	130-150
15292514-6	2004	The generation of these copolymer-specific regulatory T cells that secrete IL-4 and IL-10 and are independent of the immunizing autoantigen is very prominent among the multiple mechanisms that account for the observed suppressive effect of copolymers in EAE.	copolymer	24-33	interleukin 4	Mus musculus	75-79
15271568-6	2004	Upon increasing the copolymer concentration, however, Pluronics with comparably short PPO and PEO segment lengths, such as F87 and P85, could also be used to stabilize the DOPE liposomes.	copolymer	20-29	protoporphyrinogen oxidase	Homo sapiens	86-89
15271568-6	2004	Upon increasing the copolymer concentration, however, Pluronics with comparably short PPO and PEO segment lengths, such as F87 and P85, could also be used to stabilize the DOPE liposomes.	copolymer	20-29	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	131-134
15292514-1	2004	Copolymer 1 [Cop1, glatiramer acetate, Copaxone, poly(Y,E,A,K)n] is widely used in the treatment of relapsing/remitting multiple sclerosis in which it reduces the frequency of relapses by approximately 30%.	copolymer	0-9	COP1, E3 ubiquitin ligase	Mus musculus	13-17
15360286-2	2004	A copolymer of nitrobenzospiropyran and methyl methacrylate, poly(NSP-co-MMA) was used as a material with a photosensitive surface.	copolymer	2-11	reticulon 1	Mus musculus	66-69
15292514-6	2004	The generation of these copolymer-specific regulatory T cells that secrete IL-4 and IL-10 and are independent of the immunizing autoantigen is very prominent among the multiple mechanisms that account for the observed suppressive effect of copolymers in EAE.	copolymer	24-33	interleukin 10	Mus musculus	84-89
15058010-9	2004	Addition of FGF-9 to the copolymer did not induce proliferation and the cell numbers did not increase.	copolymer	25-34	fibroblast growth factor 9	Homo sapiens	12-17
15244444-5	2004	Therefore, the PLCL copolymer was probably composed of a soft matrix of mainly epsilon-caprolactone moieties and hard domains containing more L-lactide units to exhibit a rubberlike elasticity in virtue of the physically cross-linked structure.	copolymer	20-29	phospholipase C-like 1	Mus musculus	15-19
15835174-0	2004	Dynamic alterations of fibronectin layers on copolymer substrates with graded physicochemical characteristics.	copolymer	45-54	fibronectin 1	Homo sapiens	23-34
15003013-4	2004	Moreover, cells spread on RGDS-immobilized surfaces at 37 degrees C detach spontaneously by lowering culture temperature below the LCST as hydrated grafted copolymer chains dissociate immobilized RGDS from cell integrins.	copolymer	156-165	ral guanine nucleotide dissociation stimulator	Homo sapiens	26-30
15043254-1	2004	A new synthesized copolymer based on N-vinylimidazole-divinylbenzene (VIm-DVB) was tested as a sorbent for the solid-phase extraction (SPE) of polar analytes.	copolymer	18-27	vimentin	Homo sapiens	70-73
15003013-4	2004	Moreover, cells spread on RGDS-immobilized surfaces at 37 degrees C detach spontaneously by lowering culture temperature below the LCST as hydrated grafted copolymer chains dissociate immobilized RGDS from cell integrins.	copolymer	156-165	ral guanine nucleotide dissociation stimulator	Homo sapiens	196-200
14501658-1	2003	PURPOSE: Endoscopic injection of dextranomer/hyaluronic acid (Dx/HA) copolymer is an increasingly established treatment for primary vesicoureteral reflux (VUR) in children.	copolymer	69-78	VUR	Homo sapiens	155-158
15058998-3	2004	Depending on pH and salt concentration, the cytochrome c was found to preferentially partition into the pH-responsive copolymer-rich (bottom) phase under all conditions of pH and salt concentrations considered in the study.	copolymer	118-127	cytochrome c, somatic	Homo sapiens	44-56
14633716-4	2003	Depletion of C-Raf, an HSP90 client protein, was observed in all treatments up to 12 h. Confocal microscopy using mesochlorin e(6) as a model drug revealed that drug release caused by the lysosomal cleavage of glycylphenylalanylleucylglycine oligopeptide spacer, used as GA derivative copolymer attachment/release point, was moderately fast.	copolymer	285-294	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	13-18
14732933-1	2003	Glatiramer acetate (GA; Copaxone, also known as Copolymer 1 or Cop-1), a copolymer of amino acids, is very effective in the suppression of experimental autoimmune encephalitis (EAE), the animal model for multiple sclerosis (MS), in various species including primates.	copolymer	48-57	caspase recruitment domain family member 16	Homo sapiens	63-68
14732933-1	2003	Glatiramer acetate (GA; Copaxone, also known as Copolymer 1 or Cop-1), a copolymer of amino acids, is very effective in the suppression of experimental autoimmune encephalitis (EAE), the animal model for multiple sclerosis (MS), in various species including primates.	copolymer	73-82	caspase recruitment domain family member 16	Homo sapiens	63-68
14568412-0	2003	HPMA copolymer-bound doxorubicin targeted to tumor-specific antigen of BCL1 mouse B cell leukemia.	copolymer	5-14	cyclin D1	Mus musculus	71-75
14568412-1	2003	N-(2-Hydroxypropyl)methacrylamide (HPMA) copolymer carrier containing the anticancer drug doxorubicin and targeted with B1 monoclonal antibody (mAb) to BCL1 leukemia cells was synthesised and tested in vitro and in vivo.	copolymer	41-50	cyclin D1	Homo sapiens	152-156
15177097-2	2004	The copolymer hydrogel bead composition was characterized by elemental analysis and found to contain 5 EGDMA monomer units each VIM monomer unit.	copolymer	4-13	vimentin	Homo sapiens	128-131
14606911-1	2003	A biodegradable two block copolymer, poly(epsilon-caprolactone)-b- poly(gamma-benzyl-L-glutamic acid) (PCL-PBLG) was synthesized successfully by ring-opening polymerization of N-carboxyanhydride of gamma-benzyl-L-glutamate (BLG-NCA) with aminophenyl-terminated PCL as a macroinitiator.	copolymer	26-35	polycystin 2 like 1, transient receptor potential cation channel	Homo sapiens	103-106
14606911-1	2003	A biodegradable two block copolymer, poly(epsilon-caprolactone)-b- poly(gamma-benzyl-L-glutamic acid) (PCL-PBLG) was synthesized successfully by ring-opening polymerization of N-carboxyanhydride of gamma-benzyl-L-glutamate (BLG-NCA) with aminophenyl-terminated PCL as a macroinitiator.	copolymer	26-35	CEA cell adhesion molecule 6	Homo sapiens	228-231
14606911-1	2003	A biodegradable two block copolymer, poly(epsilon-caprolactone)-b- poly(gamma-benzyl-L-glutamic acid) (PCL-PBLG) was synthesized successfully by ring-opening polymerization of N-carboxyanhydride of gamma-benzyl-L-glutamate (BLG-NCA) with aminophenyl-terminated PCL as a macroinitiator.	copolymer	26-35	polycystin 2 like 1, transient receptor potential cation channel	Homo sapiens	261-264
14606911-3	2003	The structures of the block copolymer and its precursors from the initial step of PCL were confirmed and investigated by 1H NMR, FT-IR, GPC, and FT-ICRMS analyses and DSC measurements.	copolymer	28-37	polycystin 2 like 1, transient receptor potential cation channel	Homo sapiens	82-85
12725872-2	2003	The drug is a synthetic copolymer with an amino acid composition based on the structure of myelin basic protein, one of the autoantigens implicated in the pathogenesis of MS and experimental autoimmune encephalomyelitis (EAE).	copolymer	24-33	myelin basic protein	Homo sapiens	91-111
12906740-5	2003	We further show that the trauma-induced deficit could be reduced, both functionally and anatomically, by post-traumatic vaccination with Cop-1, a synthetic copolymer used to treat patients with multiple sclerosis and found (using a different treatment protocol) to effectively counteract the loss of neurons caused by axonal injury or glutamate-induced toxicity.	copolymer	156-165	COP1 E3 ubiquitin ligase	Homo sapiens	137-142
12741800-8	2003	The copolymer of MMA and 1 contains covalently bound iodine.	copolymer	4-13	monocyte to macrophage differentiation associated	Homo sapiens	17-20
12388663-0	2002	Pluronic p85 block copolymer enhances opioid peptide analgesia.	copolymer	19-28	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	9-12
12754837-4	2003	The antithrombin activity of polymeric systems obtained by hirudin immobilization on copolymer carriers was inversely related to the content of the copolymer, amounting to 6% of the activity of native hirudin.	copolymer	85-94	serpin family C member 1	Homo sapiens	4-16
12754837-4	2003	The antithrombin activity of polymeric systems obtained by hirudin immobilization on copolymer carriers was inversely related to the content of the copolymer, amounting to 6% of the activity of native hirudin.	copolymer	148-157	serpin family C member 1	Homo sapiens	4-16
12209939-1	2002	The purpose of this work was to synthesize and characterize a pH- and temperature-sensitive block copolymer containing repeating sequences from silk (Gly-Ala-Gly-Ala-Gly-Ser) and elastin (Gly-Val-Gly-Val-Pro) protein.	copolymer	98-107	elastin	Homo sapiens	179-186
12665301-6	2002	I1/I3 intensity ratios from vibrational bands in the fluorescence spectra and the fluorescence decay rates of attached 1-alkylpyrenyl groups are much less sensitive to changes in the copolymer composition than are those of pyrene.	copolymer	183-192	protein phosphatase 1 regulatory inhibitor subunit 1A	Homo sapiens	0-5
12177178-2	2002	A comparison with octadecyl-bonded (C18) silica gel showed that the general procedure used to purify gangliosides on C18 silica gel could be used with the copolymer.	copolymer	155-164	Bardet-Biedl syndrome 9	Homo sapiens	36-39
12149036-1	2002	Although a poly(ethylene/propylene glycol) (PEG/PPG) copolymer mixture is far too complex (approximately 150 oligomeric formulas) for conventional purification, oligomer ion compositions of <1% abundance can be separated by Fourier transform mass spectrometry and dissociated into sequence-specific fragment ions.	copolymer	53-62	serglycin	Homo sapiens	48-51
12177178-2	2002	A comparison with octadecyl-bonded (C18) silica gel showed that the general procedure used to purify gangliosides on C18 silica gel could be used with the copolymer.	copolymer	155-164	Bardet-Biedl syndrome 9	Homo sapiens	117-120
16290748-1	2002	Fourier transform infrared (FTIR) spectroscopy was used to study the conformational changes of the polyethylene oxide-polypropylene oxide-polyethylene oxide (PEO-PPO-PEO) block copolymer, Pluronic P104, in a large concentration range in a polymer-water system as a function of temperature.	copolymer	177-186	protoporphyrinogen oxidase	Homo sapiens	162-165
12115846-8	2002	The PEO/PCL ratio of copolymer was a main factor in controlling micelle size, drug-loading content, and drug release behavior.	copolymer	21-30	PHD finger protein 1	Homo sapiens	8-11
16290748-0	2002	Melt, hydration, and micellization of the PEO-PPO-PEO block copolymer studied by FTIR spectroscopy.	copolymer	60-69	protoporphyrinogen oxidase	Homo sapiens	46-49
11809732-0	2002	Oral tolerance to copolymer 1 in myelin basic protein (MBP) TCR transgenic mice: cross-reactivity with MBP-specific TCR and differential induction of anti-inflammatory cytokines.	copolymer	18-27	myelin basic protein	Mus musculus	33-53
12020957-0	2002	Oral treatment of mice with copolymer 1 (glatiramer acetate) results in the accumulation of specific Th2 cells in the central nervous system.	copolymer	28-37	heart and neural crest derivatives expressed 2	Mus musculus	101-104
12940038-0	2002	[The charge transfer process of PAN-C60 copolymer films by time-resolved fluorescence spectra].	copolymer	40-49	adenosine deaminase 2	Homo sapiens	32-35
11809732-0	2002	Oral tolerance to copolymer 1 in myelin basic protein (MBP) TCR transgenic mice: cross-reactivity with MBP-specific TCR and differential induction of anti-inflammatory cytokines.	copolymer	18-27	myelin basic protein	Mus musculus	55-58
12940038-1	2002	The charge transfer (CT) process in PAN-C60 copolymer films was studied by absorption and picosecond time-resolved photoluminescence (TRPL) spectra.	copolymer	44-53	adenosine deaminase 2	Homo sapiens	36-39
11809732-0	2002	Oral tolerance to copolymer 1 in myelin basic protein (MBP) TCR transgenic mice: cross-reactivity with MBP-specific TCR and differential induction of anti-inflammatory cytokines.	copolymer	18-27	T cell receptor alpha variable 6-3	Mus musculus	60-63
12940038-2	2002	The CT process can be confirmed from the appearing of new absorption bands and fluorescence quenching of pure PAN in the copolymer films.	copolymer	121-130	adenosine deaminase 2	Homo sapiens	110-113
11809732-0	2002	Oral tolerance to copolymer 1 in myelin basic protein (MBP) TCR transgenic mice: cross-reactivity with MBP-specific TCR and differential induction of anti-inflammatory cytokines.	copolymer	18-27	T cell receptor alpha variable 6-3	Mus musculus	116-119
12940038-5	2002	In the copolymer, the singlet excition state lifetime of PAN becomes shorter due to CT process between PAN and C60, which lead to PL quenching of PAN.	copolymer	7-16	adenosine deaminase 2	Homo sapiens	57-60
12940038-5	2002	In the copolymer, the singlet excition state lifetime of PAN becomes shorter due to CT process between PAN and C60, which lead to PL quenching of PAN.	copolymer	7-16	adenosine deaminase 2	Homo sapiens	103-106
11809732-2	2002	Glatiramer acetate [copolymer 1 (Cop1)] is a synthetic copolymer designed to mimic MBP which suppresses EAE, is used parenterally to treat multiple sclerosis (MS) and is being tested orally for efficacy in MS. We investigated the immunologic properties of Cop1 to determine the degree to which its effects were antigen specific using MBP TCR transgenic mice.	copolymer	20-29	myelin basic protein	Mus musculus	83-86
12940038-5	2002	In the copolymer, the singlet excition state lifetime of PAN becomes shorter due to CT process between PAN and C60, which lead to PL quenching of PAN.	copolymer	7-16	adenosine deaminase 2	Homo sapiens	103-106
11809732-2	2002	Glatiramer acetate [copolymer 1 (Cop1)] is a synthetic copolymer designed to mimic MBP which suppresses EAE, is used parenterally to treat multiple sclerosis (MS) and is being tested orally for efficacy in MS. We investigated the immunologic properties of Cop1 to determine the degree to which its effects were antigen specific using MBP TCR transgenic mice.	copolymer	20-29	myelin basic protein	Mus musculus	334-337
11809732-2	2002	Glatiramer acetate [copolymer 1 (Cop1)] is a synthetic copolymer designed to mimic MBP which suppresses EAE, is used parenterally to treat multiple sclerosis (MS) and is being tested orally for efficacy in MS. We investigated the immunologic properties of Cop1 to determine the degree to which its effects were antigen specific using MBP TCR transgenic mice.	copolymer	20-29	T cell receptor alpha variable 6-3	Mus musculus	338-341
11996083-3	2002	We demonstrated that HPMA copolymer-bound doxorubicin targeted to the transferrin receptor with anti-mouse CD71 mAb strongly retards tumor growth, prolongs the survival and completely cures three out of nine experimental mice with established 38C13 tumors.	copolymer	26-35	transferrin	Mus musculus	70-81
11996083-3	2002	We demonstrated that HPMA copolymer-bound doxorubicin targeted to the transferrin receptor with anti-mouse CD71 mAb strongly retards tumor growth, prolongs the survival and completely cures three out of nine experimental mice with established 38C13 tumors.	copolymer	26-35	transferrin receptor	Mus musculus	107-111
11687463-3	2001	In the present study, we examined the expression of uPAR on monocytes in patients with relapsing-remitting multiple sclerosis (RRMS) not currently participating in a clinical trial and in patients with RRMS who were enrolled in a double-blind multicenter clinical trial designed to examine the effect of glatiramer acetate (copolymer 1; Copaxone) on relapsing disease.	copolymer	324-333	plasminogen activator, urokinase receptor	Homo sapiens	52-56
11865276-1	2002	OBJECTIVES: Dextranomer/hyaluronic acid (Dx/HA) copolymer has favorable properties for endoscopic treatment of vesico-ureteral reflux (VUR).	copolymer	48-57	VUR	Homo sapiens	111-133
11865276-1	2002	OBJECTIVES: Dextranomer/hyaluronic acid (Dx/HA) copolymer has favorable properties for endoscopic treatment of vesico-ureteral reflux (VUR).	copolymer	48-57	VUR	Homo sapiens	135-138
11790485-2	2002	Its copolymer molecular weight (M(w) by GPC) was increased after this radiation.	copolymer	4-13	glycophorin C (Gerbich blood group)	Homo sapiens	40-43
12182554-4	2002	An increase in the copolymer surface concentration on 252-nm particles was found to decrease their fibrinogen uptake exponentially.	copolymer	19-28	fibrinogen beta chain	Homo sapiens	99-109
12182554-5	2002	At maximum copolymer surface concentration, the fibrinogen uptake was two orders of magnitude lower than that of bare particles (down from 3.3 mg/m2 to 0.03 mg/m2).	copolymer	11-20	fibrinogen beta chain	Homo sapiens	48-58
12182554-9	2002	When the copolymer surface concentration was increased, the PEO tails were gradually being released, acquiring higher mobility as the surface became covered by the more strongly binding PPO blocks.	copolymer	9-18	twinkle mtDNA helicase	Homo sapiens	60-63
12182554-9	2002	When the copolymer surface concentration was increased, the PEO tails were gradually being released, acquiring higher mobility as the surface became covered by the more strongly binding PPO blocks.	copolymer	9-18	protoporphyrinogen oxidase	Homo sapiens	186-189
12182557-7	2002	Fibrinogen, an adhesive protein for further cellular adhesion and activation, was effectively repelled by increasing the amount of copolymer additive.	copolymer	131-140	fibrinogen beta chain	Homo sapiens	0-10
11783881-3	2001	The trends in the electronic structures and conduction properties of the copolymers (AmBn)x as a function of the block sizes m and n, arrangement of the units (periodic or random) in the copolymer chain, and length of the copolymer chain are discussed.	copolymer	73-82	ameloblastin	Homo sapiens	85-89
11602658-1	2001	Pluronic block copolymer, P85, inhibits the P-glycoprotein (Pgp) drug efflux system and increases the permeability of a broad spectrum of drugs in the blood-brain barrier (BBB).	copolymer	15-24	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	26-29
11602658-1	2001	Pluronic block copolymer, P85, inhibits the P-glycoprotein (Pgp) drug efflux system and increases the permeability of a broad spectrum of drugs in the blood-brain barrier (BBB).	copolymer	15-24	ATP binding cassette subfamily B member 1	Homo sapiens	44-58
11602658-1	2001	Pluronic block copolymer, P85, inhibits the P-glycoprotein (Pgp) drug efflux system and increases the permeability of a broad spectrum of drugs in the blood-brain barrier (BBB).	copolymer	15-24	ATP binding cassette subfamily B member 1	Homo sapiens	60-63
11602658-8	2001	A combination of experiments examining the kinetics, concentration dependence, and directionality of P85 effects on Pgp-mediated efflux in BBMEC monolayers suggests that both energy depletion (decreasing ATP pool available for Pgp) and membrane fluidization (inhibiting Pgp ATPase activity) are critical factors contributing to the activity of the block copolymer in the BBB.	copolymer	354-363	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	101-104
11602658-8	2001	A combination of experiments examining the kinetics, concentration dependence, and directionality of P85 effects on Pgp-mediated efflux in BBMEC monolayers suggests that both energy depletion (decreasing ATP pool available for Pgp) and membrane fluidization (inhibiting Pgp ATPase activity) are critical factors contributing to the activity of the block copolymer in the BBB.	copolymer	354-363	ATP binding cassette subfamily B member 1	Homo sapiens	116-119
11278034-7	2001	In contrast, copolymer comprising natural inhibitor of lysozyme i.e. poly (N-isopropylacrylamide-co-O-acryloyl N-acetylglucosamine) lost 50% recovery of specific activity.	copolymer	13-22	lysozyme	Homo sapiens	55-63
11489505-5	2001	About two MA-PEG-Fab" fragments per chain were incorporated in the copolymer conjugates.	copolymer	67-76	FA complementation group B	Homo sapiens	17-20
11592781-7	2001	HPMA copolymer-cathespin B exhibited a longer plasma half-life (free cathepsin B t(1/2alpha)= 2.8 h; bound cathepsin B t(1/2alpha)= 3.2 h) and a 4.2-fold increase in tumour accumulation compared to the free enzyme.	copolymer	5-14	cathepsin B	Mus musculus	69-80
11592781-7	2001	HPMA copolymer-cathespin B exhibited a longer plasma half-life (free cathepsin B t(1/2alpha)= 2.8 h; bound cathepsin B t(1/2alpha)= 3.2 h) and a 4.2-fold increase in tumour accumulation compared to the free enzyme.	copolymer	5-14	cathepsin B	Mus musculus	107-118
11428675-0	2001	Microencapsulation of gentamicin in biodegradable PLA and/or PLA/PEG copolymer.	copolymer	69-78	progestagen associated endometrial protein	Homo sapiens	65-68
11428675-8	2001	The PLA/PEG copolymer was more hydrophilic than the PLA homopolymer, and with a smaller pH change in the microenvironment with polymer being degraded.	copolymer	12-21	progestagen associated endometrial protein	Homo sapiens	8-11
12836316-1	2001	The amphiphilic copolymer consisting of oligodeoxyribonucleotide (ODN; dT12) as the hydrophilic part and thermo-responsive poly(N-isopropylacrylamide) (polyNIPAAm) as the hydrophobic part was prepared.	copolymer	16-25	Aldolase 1	Drosophila melanogaster	71-75
11295216-0	2001	Preliminary evaluation of caspases-dependent apoptosis signaling pathways of free and HPMA copolymer-bound doxorubicin in human ovarian carcinoma cells.	copolymer	91-100	caspase 1	Homo sapiens	26-34
11197495-2	2001	Our main hypothesis is that the bioerodible copolymer poly(1,6-bis-p-carboxyphenoxyhexane-co-sebacic anhydride) (CPH : SA) undergoes micro-phase separation at certain copolymer compositions due to differences in relative hydrophobicity of the co-monomers, resulting in thermodynamic partitioning of drugs incorporated into these copolymers.	copolymer	167-176	carboxypeptidase E	Homo sapiens	113-116
11314801-15	2001	CONCLUSIONS: These results indicate that the PLA6,500-PEG3000 block copolymer with plastic properties works effectively as a BMP delivery system.	copolymer	68-77	bone morphogenetic protein 2	Homo sapiens	125-128
11749180-4	2001	The 3HHx fraction in the copolymer could be increased by 3-fold when the Aeromonas hydrophila orf1 gene was coexpressed with the PHA biosynthesis genes.	copolymer	25-34	putative replication protein	Aeromonas hydrophila	94-98
11197495-2	2001	Our main hypothesis is that the bioerodible copolymer poly(1,6-bis-p-carboxyphenoxyhexane-co-sebacic anhydride) (CPH : SA) undergoes micro-phase separation at certain copolymer compositions due to differences in relative hydrophobicity of the co-monomers, resulting in thermodynamic partitioning of drugs incorporated into these copolymers.	copolymer	44-53	carboxypeptidase E	Homo sapiens	113-116
11006267-3	2000	The observed k(cat) for phosphorylation of the random copolymer poly(Glu,Tyr) substrate by Csk R318A is approximately 3000-fold smaller compared with that of wild type Csk, whereas the K(m) values for ATP and poly(Glu,Tyr) are only mildly affected.	copolymer	54-63	C-terminal Src kinase	Homo sapiens	91-94
11006267-3	2000	The observed k(cat) for phosphorylation of the random copolymer poly(Glu,Tyr) substrate by Csk R318A is approximately 3000-fold smaller compared with that of wild type Csk, whereas the K(m) values for ATP and poly(Glu,Tyr) are only mildly affected.	copolymer	54-63	C-terminal Src kinase	Homo sapiens	168-171
11027347-2	2000	Copolymer 1 (Cop 1, Copaxone, glatiramer acetate), an approved drug for the treatment of multiple sclerosis, is a potent inducer of Th2 regulatory cells in both mice and humans.	copolymer	0-9	heart and neural crest derivatives expressed 2	Mus musculus	132-135
10900541-6	2000	In the present work, a new block copolymer based on poly(ethylene glycol) (PEG) was implemented as the surfactant to replace human serum albumin.	copolymer	33-42	albumin	Homo sapiens	131-144
11219753-2	2000	A grafting copolymer was introduced into sol-gel solution and the composition of the resultant organic-inorganic composite material was optimized, the tyrosinase retained its activity in the sol-gel thin film and its response to several phenol compounds was determined at 0 mV vs. Ag/AgCl (sat.	copolymer	11-20	tyrosinase	Homo sapiens	151-161
10987312-3	2000	Using cathepsin D as a model target protease, we synthesized a long-circulating, synthetic graft copolymer bearing near-infrared (NIR) fluorochromes positioned on cleavable substrate sequences.	copolymer	97-106	cathepsin D	Mus musculus	6-17
10926473-6	2000	Protein rejection studies indicate that the adsorption of fibrinogen is inhibited by copolymer preadsorption.	copolymer	85-94	fibrinogen beta chain	Homo sapiens	58-68
10900541-7	2000	It was found that the new block copolymer is a suitable replacement for human serum albumin.	copolymer	32-41	albumin	Homo sapiens	78-91
11710175-3	2000	Cell-adhesive RGDS peptide was conjugated with the copolymer as a ligand model for bioaffinity.	copolymer	51-60	ral guanine nucleotide dissociation stimulator	Homo sapiens	14-18
10842098-4	2000	Analysis of DSPGs isolated from 230-day nuchal ligament showed that this copolymer was predominantly associated with a glycoform of biglycan which was specifically elevated at this stage in development.	copolymer	73-82	biglycan	Bos taurus	132-140
10825558-7	2000	The in vitro release profiles of the encapsulated model protein lysozyme could be precisely tailored by variation of the copolymer composition and the size of the microspheres.	copolymer	121-130	lysozyme	Homo sapiens	64-72
10880734-1	2000	Copolymer 1 [Cop 1, poly (Y, E, A, K)] is a random synthetic amino acid copolymer effective in the treatment of relapsing forms of multiple sclerosis (MS), a disease that is linked to HLA-DR2 (DRB1*1501).	copolymer	0-9	dopamine receptor binding 1	Mus musculus	193-197
10717336-3	2000	In young adult naive mice, the copolymer adjuvant significantly enhanced virus-specific IgG and hemagglutination-inhibition (HI) antibody responses and augmented the production of IL-2 following vaccination.	copolymer	31-40	interleukin 2	Mus musculus	180-184
11709841-1	2000	An AB-type block copolymer composed of alpha-acetalpoly(ethylene glycol) (PEG) as the hydrophilic segment and polylactide (PLA) as the hydrophobic segment was synthesized and utilized to construct a functionalized PEG layer possessing a reactive aldehyde group at the free end of the tethered PEG chain by simple coating on polylactide substrates.	copolymer	17-26	progestagen associated endometrial protein	Homo sapiens	74-77
11709841-1	2000	An AB-type block copolymer composed of alpha-acetalpoly(ethylene glycol) (PEG) as the hydrophilic segment and polylactide (PLA) as the hydrophobic segment was synthesized and utilized to construct a functionalized PEG layer possessing a reactive aldehyde group at the free end of the tethered PEG chain by simple coating on polylactide substrates.	copolymer	17-26	progestagen associated endometrial protein	Homo sapiens	214-217
11709841-1	2000	An AB-type block copolymer composed of alpha-acetalpoly(ethylene glycol) (PEG) as the hydrophilic segment and polylactide (PLA) as the hydrophobic segment was synthesized and utilized to construct a functionalized PEG layer possessing a reactive aldehyde group at the free end of the tethered PEG chain by simple coating on polylactide substrates.	copolymer	17-26	progestagen associated endometrial protein	Homo sapiens	214-217
10728603-7	2000	HPMA copolymer-bound DOX preserved its activity inside cells, inhibited detoxification and defensive mechanisms encoded by GST-pi, BUDP, and HSP-70 genes, and limited DNA repair, replication, and biosynthesis by downregulation of Topo-IIalpha,beta, and TK1 genes.	copolymer	5-14	heat shock protein family A (Hsp70) member 4	Homo sapiens	141-147
10728603-7	2000	HPMA copolymer-bound DOX preserved its activity inside cells, inhibited detoxification and defensive mechanisms encoded by GST-pi, BUDP, and HSP-70 genes, and limited DNA repair, replication, and biosynthesis by downregulation of Topo-IIalpha,beta, and TK1 genes.	copolymer	5-14	thymidine kinase 1	Homo sapiens	253-256
15348037-2	2000	Data collected from DSC and X-ray diffractometry suggested that the copolymer chains possess a blocky structure, leading to both PCL and PEO-type crystalline structures.	copolymer	68-77	PHD finger protein 1	Homo sapiens	129-132
15348037-2	2000	Data collected from DSC and X-ray diffractometry suggested that the copolymer chains possess a blocky structure, leading to both PCL and PEO-type crystalline structures.	copolymer	68-77	twinkle mtDNA helicase	Homo sapiens	137-140
10640656-6	2000	The release rate of lysozyme from PEG/PBT films could be tailored very precisely by controlling the copolymer composition.	copolymer	100-109	lysozyme	Homo sapiens	20-28
11710175-7	2000	Probably, copolymer vehicles were concentrated on a cell surface through the binding of RGDS and integrin and the release of lipid inducers was caused by the disruption of vehicles in response to temperature.	copolymer	10-19	ral guanine nucleotide dissociation stimulator	Homo sapiens	88-92
10619568-9	1999	Copolymer 1 (Glatiramer acetate) suppresses EAE, demyelination, and Galectin-3/MAC-2 expression.	copolymer	0-9	lectin, galactose binding, soluble 3	Mus musculus	68-78
18238674-7	2000	The ice water-quenched 15% HFP copolymer exhibited the lowest strain response among the three polymeric materials tested, /spl ap/3%, with a dielectric constant of 12.2.	copolymer	31-40	sphingosine-1-phosphate lyase 1	Homo sapiens	123-126
10528075-4	1999	The structural analysis of Pluronic/PCL block copolymer was carried out using FT-IR, 1H NMR, GPC, WAXD, DSC and TGA measurements.	copolymer	46-55	glycophorin C (Gerbich blood group)	Homo sapiens	93-96
10528075-4	1999	The structural analysis of Pluronic/PCL block copolymer was carried out using FT-IR, 1H NMR, GPC, WAXD, DSC and TGA measurements.	copolymer	46-55	desmocollin 3	Homo sapiens	104-107
10528075-4	1999	The structural analysis of Pluronic/PCL block copolymer was carried out using FT-IR, 1H NMR, GPC, WAXD, DSC and TGA measurements.	copolymer	46-55	T-box transcription factor 1	Homo sapiens	112-115
10619568-9	1999	Copolymer 1 (Glatiramer acetate) suppresses EAE, demyelination, and Galectin-3/MAC-2 expression.	copolymer	0-9	lectin, galactose binding, soluble 3	Mus musculus	79-84
10450921-1	1999	PURPOSE: To study peculiarities and the mechanism of the anticancer effect of free and HPMA copolymer-bound ADR in sensitive and resistant human ovarian carcinoma cells.	copolymer	92-101	aldo-keto reductase family 1 member B	Homo sapiens	108-111
19003147-4	1999	The highest production of CEA per cell was observed for the CW2 cells on poly(gamma-benzyl-L-glutamate) and its diblock copolymer films prepared by the Langmuir-Blodgett method in the medium containing 5 mM aspirin after 168 hr of inoculation.	copolymer	120-129	CEA cell adhesion molecule 3	Homo sapiens	26-29
10519946-7	1999	These results indicate that peptide vaccination using a formulation based on high molecular weight nonionic block copolymer in a simple water-in-oil or a multiple emulsion format can induce virus-specific CD8(+) T cell responses and confer protection sufficient enough to prevent the establishment of a persistent infection.	copolymer	114-123	CD8a molecule	Homo sapiens	205-208
10496651-1	1999	PURPOSE: Previous studies demonstrated that inhibition of P glycoprotein (P-gp) by Pluronic P85 (P85) block copolymer increases apical (AP) to basolateral (BL) transport of rhodamine 123 (R123) in the polarized monolayers of bovine brain microvessel endothelial cells (BBMEC) and Caco-2 cells.	copolymer	108-117	phosphoglycolate phosphatase	Bos taurus	58-72
10496651-1	1999	PURPOSE: Previous studies demonstrated that inhibition of P glycoprotein (P-gp) by Pluronic P85 (P85) block copolymer increases apical (AP) to basolateral (BL) transport of rhodamine 123 (R123) in the polarized monolayers of bovine brain microvessel endothelial cells (BBMEC) and Caco-2 cells.	copolymer	108-117	phosphoglycolate phosphatase	Bos taurus	74-78
10496651-1	1999	PURPOSE: Previous studies demonstrated that inhibition of P glycoprotein (P-gp) by Pluronic P85 (P85) block copolymer increases apical (AP) to basolateral (BL) transport of rhodamine 123 (R123) in the polarized monolayers of bovine brain microvessel endothelial cells (BBMEC) and Caco-2 cells.	copolymer	108-117	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	92-95
10496651-1	1999	PURPOSE: Previous studies demonstrated that inhibition of P glycoprotein (P-gp) by Pluronic P85 (P85) block copolymer increases apical (AP) to basolateral (BL) transport of rhodamine 123 (R123) in the polarized monolayers of bovine brain microvessel endothelial cells (BBMEC) and Caco-2 cells.	copolymer	108-117	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	97-100
10332063-4	1999	In the case of the linear block copolymers, a reduced lactic acid content in a linear block copolymer yielded smaller particles, a lower encapsulation efficiency, and a higher initial drug release both in the case of EPO and FITC-dextran.	copolymer	32-41	erythropoietin	Homo sapiens	217-220
10202010-1	1999	Copolymer 1 (Cop 1, poly (Y, E, A, K)) is a random synthetic amino acid copolymer effective in the treatment of relapsing forms of multiple sclerosis (MS).	copolymer	0-9	COP1 E3 ubiquitin ligase	Homo sapiens	13-18
10210724-9	1999	Leakage rate of insulin from copolymer containing between 7 and 39% by weight of PEG were similar.	copolymer	29-38	insulin	Homo sapiens	16-23
10213370-5	1999	Inhibition of MRP-mediated transport was dependent on the composition of Pluronic block copolymer: the more hydrophobic copolymer had the greater effect on FLU uptake in Panc-1 monolayers (L81 > P85 > F108).	copolymer	88-97	ATP binding cassette subfamily C member 3	Homo sapiens	14-17
10213370-5	1999	Inhibition of MRP-mediated transport was dependent on the composition of Pluronic block copolymer: the more hydrophobic copolymer had the greater effect on FLU uptake in Panc-1 monolayers (L81 > P85 > F108).	copolymer	120-129	ATP binding cassette subfamily C member 3	Homo sapiens	14-17
9846830-1	1998	The synthetic amino acid copolymer, copolymer 1 (Cop 1) induces T suppressor (Ts) lines/clones, which are confined to the Th2 pathway, cross react with myelin basic protein (MBP), but not with other myelin antigens on the level of Th2 cytokine secretion.	copolymer	25-34	myelin basic protein	Homo sapiens	152-172
9880545-0	1999	Molecular parameters of type IV alpha-internexin and type IV-type III alpha-internexin-vimentin copolymer intermediate filaments.	copolymer	96-105	vimentin	Homo sapiens	87-95
9880545-3	1999	First, we have demonstrated by cross-linking experiments that bacterially expressed forms of alpha-internexin and vimentin form heterodimer molecules in vitro that assemble into copolymer intermediate filaments.	copolymer	178-187	vimentin	Homo sapiens	114-122
15348946-8	1998	Pre-adsorption of fibronectin on to the copolymer surface substantially increased cell attachment in all cases.	copolymer	40-49	fibronectin 1	Homo sapiens	18-29
9808532-12	1998	TGF-beta1 released in a sustained manner from copolymer matrices: (i) markedly inhibited colonic ACF formation and the number of aberrant crypts and (ii) significantly reduced colonic tumor formation and size.	copolymer	46-55	transforming growth factor, beta 1	Rattus norvegicus	0-9
9846830-1	1998	The synthetic amino acid copolymer, copolymer 1 (Cop 1) induces T suppressor (Ts) lines/clones, which are confined to the Th2 pathway, cross react with myelin basic protein (MBP), but not with other myelin antigens on the level of Th2 cytokine secretion.	copolymer	25-34	myelin basic protein	Homo sapiens	174-177
9724909-0	1998	HPMA copolymer bound adriamycin overcomes MDR1 gene encoded resistance in a human ovarian carcinoma cell line.	copolymer	5-14	ATP binding cassette subfamily B member 1	Homo sapiens	42-46
9740005-3	1998	The surface micropattern appeared and disappeared interchangeably, as observed under a phase-contrast microscope, by varying the temperature between 10 degrees C and 37 degrees C. The copolymer-grafted polystyrene surface was hydrophobic at 37 degrees C and hydrophilic at 10 degrees C. Albumin and fibronectin adsorption on the matrix was investigated using the fluorescent-labeling method.	copolymer	184-193	fibronectin 1	Mus musculus	299-310
9773812-6	1998	An increase in the PPO block size of the copolymer also appears to increase its protein resistance.	copolymer	41-50	protoporphyrinogen oxidase	Homo sapiens	19-22
9609551-3	1998	METHODS: LHRH vaccine was encapsulated in poly-lactic-co-glycolic acid (PLGA) 50:50 copolymer microspheres of reproducible physicochemical characteristics.	copolymer	84-93	gonadotropin releasing hormone 1	Homo sapiens	9-13
9443407-2	1998	We synthesized TNF-alpha conjugated with the copolymer of divinyl ether and maleic anhydride (DIVEMA), which has intrinsic antitumor activity as a synthetic biological response modifier.	copolymer	45-54	tumor necrosis factor	Mus musculus	15-24
9743446-1	1998	Binding of HPMA copolymer-conjugated doxorubicin targeted with monoclonal antibodies directed against various T-cell surface receptors, i.e. Thy1.2 (CDw90), I-A (MHC class II.	copolymer	16-25	thymus cell antigen 1, theta	Mus musculus	141-147
9271317-0	1997	Studies on the mechanism and specificity of the effect of the synthetic random copolymer GLAT on graft-versus-host disease.	copolymer	79-88	galactose mutarotase	Homo sapiens	89-93
9469907-0	1998	Analysis of DOSY and GPC-NMR Experiments on Polymers by Multivariate Curve Resolution Multivariate curve resolution (MCR) was successfully applied to the analysis of DOSY experiments on polymer mixtures and GPC-NMR experiments on industrial copolymer samples.	copolymer	241-250	glycophorin C (Gerbich blood group)	Homo sapiens	21-24
9469907-0	1998	Analysis of DOSY and GPC-NMR Experiments on Polymers by Multivariate Curve Resolution Multivariate curve resolution (MCR) was successfully applied to the analysis of DOSY experiments on polymer mixtures and GPC-NMR experiments on industrial copolymer samples.	copolymer	241-250	glycophorin C (Gerbich blood group)	Homo sapiens	207-210
9616708-4	1997	The adherence of THP-1 cells to copolymer-coated beads correlates well with the amount of fibrinogen bound to the beads.	copolymer	32-41	fibrinogen beta chain	Homo sapiens	90-100
9345288-0	1997	Bioconjugation of tumor necrosis factor-alpha with the copolymer of divinyl ether and maleic anhydride increasing its antitumor potency.	copolymer	55-64	tumor necrosis factor	Mus musculus	18-45
9237101-1	1997	Copolymer 1 (Cop 1), a synthetic copolymer of amino acids, effective in suppression of experimental allergic encephalomyelitis (EAE) and myelin basic protein (MBP), was shown to bind extensively and promiscuously to the class II MHC molecules on antigen-presenting cells (APC) without prior processing.	copolymer	0-9	myelin basic protein	Homo sapiens	137-157
9237101-1	1997	Copolymer 1 (Cop 1), a synthetic copolymer of amino acids, effective in suppression of experimental allergic encephalomyelitis (EAE) and myelin basic protein (MBP), was shown to bind extensively and promiscuously to the class II MHC molecules on antigen-presenting cells (APC) without prior processing.	copolymer	0-9	myelin basic protein	Homo sapiens	159-162
9237101-1	1997	Copolymer 1 (Cop 1), a synthetic copolymer of amino acids, effective in suppression of experimental allergic encephalomyelitis (EAE) and myelin basic protein (MBP), was shown to bind extensively and promiscuously to the class II MHC molecules on antigen-presenting cells (APC) without prior processing.	copolymer	0-9	major histocompatibility complex, class I, C	Homo sapiens	229-232
9271317-2	1997	The synthetic random copolymer of the amino acids, L-Glu, L-Lys, L-Ala and L-Tyr, termed GLAT, with promiscuous binding to multiple MHC class II alleles, reduces the incidence, onset and severity of disease in the BIO.D2 --> BALB/c model of lethal GVHD.	copolymer	21-30	galactose mutarotase	Homo sapiens	89-93
9271317-2	1997	The synthetic random copolymer of the amino acids, L-Glu, L-Lys, L-Ala and L-Tyr, termed GLAT, with promiscuous binding to multiple MHC class II alleles, reduces the incidence, onset and severity of disease in the BIO.D2 --> BALB/c model of lethal GVHD.	copolymer	21-30	major histocompatibility complex, class I, C	Homo sapiens	132-135
9239579-7	1997	The presence of excess block copolymer in the uncleaned preparations resulted in further suppression of HSA adsorption, which was thought to be due to their detergent properties.	copolymer	29-38	albumin	Homo sapiens	104-107
9209407-0	1997	Chemical modification of L-asparaginase with comb-shaped copolymer of poly(ethylene glycol) derivative and maleic anhydride.	copolymer	57-66	asparaginase like 1	Mus musculus	25-39
9505199-7	1997	A copolymer (IAP) without boronic acid groups was also prepared using N-phenylacrylamide (P) as a comonomer instead of 3-acrylamidophenylboronic acid in the IAB copolymer to investigate the effect of boronic acid moieties on the capillary formation of the cultured cells.	copolymer	2-11	intestinal-type alkaline phosphatase	Bos taurus	13-16
8932333-6	1996	The anti-tumour activity of the drug/copolymer compositions depends on the concentration of the copolymer and its hydrophobicity, as determined by the ratio of the lengths of hydrophilic PEO and hydrophobic PPO segments.	copolymer	37-46	protoporphyrinogen oxidase	Mus musculus	207-210
8932333-6	1996	The anti-tumour activity of the drug/copolymer compositions depends on the concentration of the copolymer and its hydrophobicity, as determined by the ratio of the lengths of hydrophilic PEO and hydrophobic PPO segments.	copolymer	96-105	protoporphyrinogen oxidase	Mus musculus	207-210
8958051-5	1996	This T-helper 1 (Th1) type, GAT (synthetic copolymer of L-glutamic acid, L-alanine and L-tyrosine)-specific clone is characterized by an efficient downregulation of interleukin-2 receptor (IL-2R) with time following antigenic stimulation.	copolymer	43-52	glycine-N-acyltransferase	Mus musculus	28-31
8958051-5	1996	This T-helper 1 (Th1) type, GAT (synthetic copolymer of L-glutamic acid, L-alanine and L-tyrosine)-specific clone is characterized by an efficient downregulation of interleukin-2 receptor (IL-2R) with time following antigenic stimulation.	copolymer	43-52	interleukin 2 receptor, alpha chain	Mus musculus	165-187
8958051-5	1996	This T-helper 1 (Th1) type, GAT (synthetic copolymer of L-glutamic acid, L-alanine and L-tyrosine)-specific clone is characterized by an efficient downregulation of interleukin-2 receptor (IL-2R) with time following antigenic stimulation.	copolymer	43-52	interleukin 2 receptor, alpha chain	Mus musculus	189-194
8866326-2	1996	In the present work, PLG (50:50) copolymer has been used to deliver diclofenac sodium in the form of microspheres and in situ gel-forming systems, both of which can be injected subcutaneously.	copolymer	33-42	plasminogen	Rattus norvegicus	21-24
8781516-4	1996	In this study, we investigated the biorecognizability of specific oligopeptide sequences linking 5-fluorouracil to a water-soluble copolymer carrier based on N-(2-hydroxypropyl) methacrylamide by human cathepsin B (EC 3.4.22.1), cathepsin H(EC 3.4.22.6), and a homogenate of the human colon adenocarcinoma cell line SW 480.	copolymer	131-140	cathepsin B	Homo sapiens	202-213
8866326-5	1996	Injectable microspheres and in situ gel-forming implant systems of PLG (50:50) copolymer may therefore be considered as prospective implantable controlled-release dosage forms to deliver drugs in long-term therapy of chronic ailments.	copolymer	79-88	plasminogen	Rattus norvegicus	67-70
8965116-3	1996	Accordingly, copolymer 1, a random synthetic amino acid copolymer crossreactive with MBP and highly protective against the induction of EAE with MBP or PLP, is not being extensively tested in clinical studies as a therapeutic agent for MS.	copolymer	13-22	proteolipid protein (myelin) 1	Mus musculus	152-155
18626991-3	1996	Epidermal growth factor (EGF) was incorporated (0.11%) into microspheres (19 +/- 12 mum) fabricated from a copolymer of lactic and glycolic acid using a double emulsion technique.	copolymer	107-116	epidermal growth factor like 1	Rattus norvegicus	0-23
8965119-2	1996	Copolymer 1 can suppress both acute and chronic relapsing EAE induced by either whole brain homogenate or the purified encephalitogens myelin basic protein (MBP) and proteolipid protein (PLP).	copolymer	0-9	myelin basic protein	Homo sapiens	135-155
8965119-2	1996	Copolymer 1 can suppress both acute and chronic relapsing EAE induced by either whole brain homogenate or the purified encephalitogens myelin basic protein (MBP) and proteolipid protein (PLP).	copolymer	0-9	proteolipid protein 1	Homo sapiens	166-185
8965119-2	1996	Copolymer 1 can suppress both acute and chronic relapsing EAE induced by either whole brain homogenate or the purified encephalitogens myelin basic protein (MBP) and proteolipid protein (PLP).	copolymer	0-9	proteolipid protein 1	Homo sapiens	187-190
8983343-8	1996	Therefore, the possible role of the copolymer in inhibition of non-P-gp drug resistance is hypothesized, which may also explain the sensitization of MDR cells with respect to non-MDR type drugs as well as sensitization of parental cells.	copolymer	36-45	phosphoglycolate phosphatase	Homo sapiens	67-71
8706041-0	1996	In vivo studies of the new gonadotropin-releasing hormone antagonist--copolymer conjugates having antitumor activity.	copolymer	70-79	gonadotropin releasing hormone 1	Mus musculus	27-57
8632064-0	1996	Copolymer 1 inhibits chronic relapsing experimental allergic encephalomyelitis induced by proteolipid protein (PLP) peptides in mice and interferes with PLP-specific T cell responses.	copolymer	0-9	proteolipid protein (myelin) 1	Mus musculus	90-109
8632064-0	1996	Copolymer 1 inhibits chronic relapsing experimental allergic encephalomyelitis induced by proteolipid protein (PLP) peptides in mice and interferes with PLP-specific T cell responses.	copolymer	0-9	proteolipid protein (myelin) 1	Mus musculus	111-114
8632064-0	1996	Copolymer 1 inhibits chronic relapsing experimental allergic encephalomyelitis induced by proteolipid protein (PLP) peptides in mice and interferes with PLP-specific T cell responses.	copolymer	0-9	proteolipid protein (myelin) 1	Mus musculus	153-156
9041044-1	1996	Ovalbumin (OVA) was chemically modified with poly(ethylene glycol) (PEG) derivatives: activated PEG2, 2,4-bis[O-methoxypoly(ethylene glycol)]-6-chloro-s-triazine and activated PM13, copolymer of poly(oxyethylene) allyl methyl diether and maleic anhydride.	copolymer	182-191	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	0-9
8957705-6	1996	Both FN and VN adsorption on SA copolymer surfaces were increased with increasing polyamine content in the copolymer, suggesting a crucial role of these cell-adhesion proteins in BAEC adhesion and subsequent growth behavior on SA copolymer surfaces.	copolymer	32-41	fibronectin 1	Bos taurus	5-7
10167362-2	1996	The original hydrogel polymer, a copolymer of 2-hydroxyethyl methacrylate and ethylene dimethacrylate, was developed by Wichterle and Lim in 1954.	copolymer	33-42	PDZ and LIM domain 5	Homo sapiens	134-137
8957705-6	1996	Both FN and VN adsorption on SA copolymer surfaces were increased with increasing polyamine content in the copolymer, suggesting a crucial role of these cell-adhesion proteins in BAEC adhesion and subsequent growth behavior on SA copolymer surfaces.	copolymer	32-41	vitronectin	Bos taurus	12-14
9238883-11	1996	The confidence interval calculations for both incremental DFS and DFT support the conclusion that a dentifrice containing 0.3% triclosan and 2.0% PVM/MA copolymer in a 0.243% NaF/silica (1100 ppm F) base provides a level of anticaries efficacy which is "at least as good as" that provided by a dentifrice containing 1100 NaF/silica without those additive agents.	copolymer	153-162	C-X-C motif chemokine ligand 8	Homo sapiens	175-178
9238884-11	1996	The confidence interval calculations for both incremental DFS and DFT support the conclusion that a dentifrice containing 0.3% triclosan and 2.0% PVM/MA copolymer in a 0.331% NaF/silica (1500 ppm F) base provides a level of anticaries efficacy which is "at least as good as" that provided by a dentifrice containing 1500 NaF/silica, without those additive agents.	copolymer	153-162	C-X-C motif chemokine ligand 8	Homo sapiens	175-178
7711033-6	1995	Interestingly, condensation of the alternating copolymer poly(dI-dC).poly(dI-dC) by TP2 was much less as compared to that of poly(dG-dC).poly(dG-dC).	copolymer	47-56	transition protein 2	Rattus norvegicus	84-87
7948093-1	1994	L-Asparaginase from Escherichia coli was coupled with two types of comb-shaped copolymer of poly-(ethylene glycol) derivative and maleic anhydride (activated PM), having molecular weights of 13,000 and 100,000 (activated PM13 and PM100, respectively) with multivalent reaction sites.	copolymer	79-88	asparaginase and isoaspartyl peptidase 1	Rattus norvegicus	0-14
7829555-3	1994	Polymer A is a copolymer of methyl methacrylate (MMA) and 1 (80 and 20 mol%, respectively).	copolymer	15-24	monocyte to macrophage differentiation associated	Homo sapiens	28-59
8198528-3	1994	Electron microscopy of copolymer filaments, alone and bound to actin, indicates that the myosin heads are distributed randomly along the co-polymer filaments.	copolymer	23-32	myosin heavy chain 14	Homo sapiens	89-95
8124471-1	1994	Aqueous two-phase partition and temperature-induced phase separation using a non-ionic, random copolymer composed of 20% ethylene oxide, 80% propylene oxide (EO20 PO80) has been used for purification of glucose-6-phosphate dehydrogenase, hexokinase and 3-phosphoglycerate kinase from bakers" yeast.	copolymer	95-104	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	203-236
8360013-4	1993	Recent investigations using copolymer implants as an intraocular delivery system for growth factors have demonstrated that the state of differentiation of RPE cells in the stage 22-24 chicken embryo can be altered in vivo by specific growth factors, aFGF and bFGF.	copolymer	28-37	fibroblast growth factor 2	Gallus gallus	259-263
1319582-5	1992	Copolymer-induced ACTH release was dose-, time-, and temperature-dependent.	copolymer	0-9	pro-opiomelanocortin-alpha	Mus musculus	18-22
1319582-10	1992	These data support an ionophore mechanism for copolymer-induced ACTH release in which changes in the physicochemical structure of the copolymers may affect their interaction with cell membranes.	copolymer	46-55	pro-opiomelanocortin-alpha	Mus musculus	64-68
1567419-0	1992	Chemical modification of L-asparaginase with a comb-shaped copolymer of polyethylene glycol derivative and maleic anhydride.	copolymer	59-68	asparaginase and isoaspartyl peptidase 1	Homo sapiens	25-39
34635270-3	2022	Subsequent electro-polymerization not only locked the recognition site between copolymer and lysozyme but also created a conductive polymer network, which can enhance the electron transfer rate and increase the conductivity of the film.	copolymer	79-88	lysozyme	Homo sapiens	93-101
1577835-6	1992	All of the high-water copolymer compositions developed resulted in lysozyme uptake typical of nonionic high-water-content hydrogels and oxygen permeability levels greater than 50 (cm3-O2(STP).cm)/(s.cm2.mm Hg) x 10(-11).	copolymer	22-31	thyroid hormone receptor interactor 10	Homo sapiens	187-190
1370347-0	1992	Synthetic copolymer 1 inhibits human T-cell lines specific for myelin basic protein.	copolymer	10-19	myelin basic protein	Homo sapiens	63-83
1714060-1	1991	In clinical trials, copolymer I (Cop 1) appears to reduce the number of exacerbations in early relapsing-remitting multiple sclerosis.	copolymer	20-29	COP1 E3 ubiquitin ligase	Homo sapiens	33-38
2005667-4	1991	The antisera bound to ARS conjugated to the synthetic copolymer glutamic acid60 tyrosine30 when diluted as high as 1:4096.	copolymer	54-63	secreted Ly6/Plaur domain containing 1	Mus musculus	22-25
33777920-2	2021	Herein, a hyaluronic acid/Pluronic F68-based copolymer-mixed micelle was constructed for targeted delivery of chemotherapeutical agent docetaxel (PHDM) in combination with programmed cell death ligand-1(PD-L1) antibody.	copolymer	45-54	CD274 molecule	Homo sapiens	203-208
34602005-1	2022	A novel cyclodextrin-contained copolymer poly(AAc-co-SA-AC-co-allyl-beta-CD) was synthesized based on the method of redox radical polymerization.	copolymer	31-40	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	68-75
1457677-0	1992	Human serum albumin as a probe for surface conditioning (opsonization) of block copolymer-coated microspheres.	copolymer	80-89	albumin	Homo sapiens	12-19
2083644-0	1990	Interactions of a model block copolymer drug delivery system with two serum proteins and myoglobin.	copolymer	30-39	myoglobin	Homo sapiens	89-98
34883118-3	2022	Here, we demonstrate that fibril formation of amylin is altered by synthetic amphipathic copolymer derivatives of the styrene-maleic-acid (SMAQA and SMAEA).	copolymer	89-98	islet amyloid polypeptide	Homo sapiens	46-52
34797674-2	2021	This study investigates the possibility of employing the dually sensitive self-assembly of an ethylene oxide-propylene oxide star block copolymer, Tetronic T904, to influence photoinduced electron transfer (ET) reactions, on switching from the assembled state (micelle) when temperature is above the critical micelle temperature (CMT) and pH of the medium is above the pKa of T904 to the dissociated (unimer) state when either the temperature is below the CMT or the polymer is protonated.	copolymer	136-145	major facilitator superfamily domain containing 11	Homo sapiens	207-209
34256224-2	2021	A novel water-soluble chitosan (CS)-based copolymer was prepared to be used as a carrier to provide a pH-stable environment for loading PC.	copolymer	42-51	citrate synthase	Homo sapiens	32-34
34717015-0	2022	Lateral Fully Organic P-N Diodes Created in A Single donor-acceptor Copolymer.	copolymer	68-77	U6 snRNA biogenesis phosphodiesterase 1	Homo sapiens	22-25
34591491-1	2021	The study aims to investigate the in vivo distribution, antitumor effect, and safety of cell membrane-penetrating peptide-modified disulfide bond copolymer nanoparticles loaded with small-interfering RNA (siRNA) targeting epidermal growth factor receptor (EGFR) and bromodomain-containing protein 4 (BRD4) in triple-negative breast cancer (TNBC).	copolymer	146-155	epidermal growth factor receptor	Mus musculus	222-254
34591491-1	2021	The study aims to investigate the in vivo distribution, antitumor effect, and safety of cell membrane-penetrating peptide-modified disulfide bond copolymer nanoparticles loaded with small-interfering RNA (siRNA) targeting epidermal growth factor receptor (EGFR) and bromodomain-containing protein 4 (BRD4) in triple-negative breast cancer (TNBC).	copolymer	146-155	epidermal growth factor receptor	Mus musculus	256-260
34591491-1	2021	The study aims to investigate the in vivo distribution, antitumor effect, and safety of cell membrane-penetrating peptide-modified disulfide bond copolymer nanoparticles loaded with small-interfering RNA (siRNA) targeting epidermal growth factor receptor (EGFR) and bromodomain-containing protein 4 (BRD4) in triple-negative breast cancer (TNBC).	copolymer	146-155	bromodomain containing 4	Mus musculus	266-298
34591491-1	2021	The study aims to investigate the in vivo distribution, antitumor effect, and safety of cell membrane-penetrating peptide-modified disulfide bond copolymer nanoparticles loaded with small-interfering RNA (siRNA) targeting epidermal growth factor receptor (EGFR) and bromodomain-containing protein 4 (BRD4) in triple-negative breast cancer (TNBC).	copolymer	146-155	bromodomain containing 4	Mus musculus	300-304
34797674-0	2021	Fate of Photoinduced Electron Transfer Reactions with Temperature- and pH-Induced Assembly/Disassembly of Star Block Copolymer Micelles.	copolymer	117-126	steroidogenic acute regulatory protein	Homo sapiens	106-110
34797674-2	2021	This study investigates the possibility of employing the dually sensitive self-assembly of an ethylene oxide-propylene oxide star block copolymer, Tetronic T904, to influence photoinduced electron transfer (ET) reactions, on switching from the assembled state (micelle) when temperature is above the critical micelle temperature (CMT) and pH of the medium is above the pKa of T904 to the dissociated (unimer) state when either the temperature is below the CMT or the polymer is protonated.	copolymer	136-145	steroidogenic acute regulatory protein	Homo sapiens	125-129
34940452-0	2021	Highly Effective Anti-Organic Fouling Performance of a Modified PVDF Membrane Using a Triple-Component Copolymer of P(Stx-co-MAAy)-g-fPEGz as the Additive.	copolymer	103-112	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	Homo sapiens	118-121
34810249-3	2021	Here, we demonstrate a feasible strategy for adaptive visible camouflage based on light-driven dynamic surface wrinkles using a bilayer system comprising an anthracene-containing copolymer (PAN) and pigment-containing poly (dimethylsiloxane) (pigment-PDMS).	copolymer	179-188	adenosine deaminase 2	Homo sapiens	190-193
34242455-3	2021	In this contribution, we report the synthesis of 3D hierarchical assemblies with distinct secondary domains formed through the intramolecular folding of a block copolymer containing a coil-like poly(styrene) (PS) block with a helical poly(isocyanide) (PIC) block induced by phenyl-pentafluorophenyl quadrupole interactions.	copolymer	161-170	coilin	Homo sapiens	184-188
34672613-9	2022	The copolymer was adsorbed onto mucin at pH 3; however, the adsorption decreased at pH 7.4.	copolymer	4-13	LOC100508689	Homo sapiens	32-37
34683317-4	2021	Formulation of a gas-permeable, high-resolution PDMS resin was developed using a methacrylate-PDMS copolymer and the novel combination of a photoabsorber, Sudan I, and photosensitizer, 2-Isopropylthioxanthone.	copolymer	99-108	gastrin	Homo sapiens	17-20
34218011-0	2021	Design and synthesis of polyacrylic acid/deoxycholic acid-modified chitosan copolymer and a close inspection of human growth hormone-copolymer interactions: An experimental and computational study.	copolymer	133-142	growth hormone 1	Homo sapiens	118-132
34643079-8	2021	Moreover, the PIM-(durene-PEG/PPG) copolymer membranes display excellent anti-aging performance for up to 1 year.	copolymer	35-44	serglycin	Homo sapiens	30-33
34632775-2	2021	Herein, a semicrystalline fluorinated copolymer ionogel (SFCI) with extremely high stretchability, underwater stability, and fast self-healability was fabricated, among which hydrophobic ionic liquids ((BMIM)(TFSI)) were selectively enriched in fluoroacrylate segment domains of the fluorinated copolymer matrix through unique ion-dipole interactions.	copolymer	38-47	Fas activated serine/threonine kinase	Homo sapiens	125-129
34523660-4	2021	After encapsulating it with a biodegradable copolymer (DSPE-mPEG2000-cRGD), well distributed organic TQs-PEG4 nanoparticles (NPs) are formed with good water dispersity and excellent active tumor-targeting property.	copolymer	44-53	small nuclear ribonucleoprotein N	Mus musculus	105-109
34062235-3	2021	RESULTS: A hybrid nanocarrier composed of calcium phosphate as the inorganic phase and a block copolymer containing polyanions as organic phase, named HNPs, was developed to deliver VEGF siRNA into metastatic breast cancer in mice.	copolymer	95-104	vascular endothelial growth factor A	Mus musculus	182-186
34170581-4	2021	The nanoparticles are engineered by integrating an ionizable block copolymer and acid-liable phenylboronate ester (PBE) dynamic covalent bonds for tumor-specific delivery of the ferroptosis inducer, a glutathione peroxidase 4 inhibitor RSL-3.	copolymer	67-76	glutathione peroxidase 4	Homo sapiens	201-225
34605672-4	2022	In this study, the well-known biodegradable copolymer poly (epsilon-caprolactone-co-L, L-lactide) (PLCL) was electrospun into high porosity external sheaths.	copolymer	44-53	phospholipase C-like 1	Mus musculus	99-103
35576931-3	2022	This study advanced the anti-biofouling property of S-ISE sensors through precisely coating a self-assembled channel-type zwitterionic copolymer poly(trifluoroethyl methacrylate-random-sulfobetaine methacrylate) (PTFEMA-r-SBMA) on the sensor surface using electrospray.	copolymer	135-144	androgen receptor	Homo sapiens	222-226
34063011-4	2021	The synthesized copolymer with optimized grafting parameters has been characterized by Infrared Spectroscopy and Thermal Analysis (DSC).	copolymer	16-25	desmocollin 3	Homo sapiens	131-134
35569872-3	2022	This protocol utilizes the quenching phenomena displayed by QDs due to the competitive binding of As3+ ions and cationic copolymer to the aptamer.	copolymer	121-130	PDS5 cohesin associated factor B	Homo sapiens	98-101
35335582-2	2022	Consequently, the grafted copolymer is applied as a component in a metallocene polyolefin-based hot-melt adhesive composition with increased adhesion.	copolymer	26-35	alcohol dehydrogenase iron containing 1	Homo sapiens	96-99
35313287-0	2022	pH-responsive and CD44-targeting polymer micelles based on CD44p-conjugated amphiphilic block copolymer PEG-b-HES-b-PLA for delivery of emodin to breast cancer cells.	copolymer	94-103	CD44 molecule (Indian blood group)	Homo sapiens	18-22
35313287-0	2022	pH-responsive and CD44-targeting polymer micelles based on CD44p-conjugated amphiphilic block copolymer PEG-b-HES-b-PLA for delivery of emodin to breast cancer cells.	copolymer	94-103	CD44 molecule (Indian blood group)	Homo sapiens	59-64
35238538-2	2022	In this paper, we design a tough and flexible amphoteric copolymer-based (AC) hydrogel with bioactive groups for bone regeneration.	copolymer	57-66	N-acylsphingosine amidohydrolase 1	Rattus norvegicus	74-76
35241773-5	2022	Surprisingly, activation of the insulin receptor and proximal downstream signalling was detected upon copolymer extraction even in the absence of insulin stimulation.	copolymer	102-111	insulin receptor	Homo sapiens	32-48
35142781-0	2022	Dynamics of small molecules within the F127 PEO-PPO-PEO triblock copolymer gel and sol phases studied at the molecular scale.	copolymer	65-74	protoporphyrinogen oxidase	Homo sapiens	48-51
35309424-2	2022	The addition of silica to P(NIPAAm-co-AAc) copolymer hydrogel has the potential to open up new applications in the development of thermosensitive building materials by leveraging the favorable thermal characteristics of P(NIPAAm-co-AAc).	copolymer	43-52	glycine-N-acyltransferase	Homo sapiens	38-41
35183097-0	2022	Dynamic molecular conformational change leading to energy transfer in F8-5% BSP copolymer revealed by single-molecule spectroscopy.	copolymer	80-89	integrin binding sialoprotein	Homo sapiens	76-79
35215686-2	2022	The copolymer ability to self-fold in single-chain nano-sized structures (unimer micelles) in aqueous solutions was exploited to encapsulate Combretastatin A-4 (CA-4), which is a very hydrophobic anticancer drug.	copolymer	4-13	carbonic anhydrase 4	Mus musculus	161-165
35129351-1	2022	Here, we report the magnetic field-induced self-assembly of a conjugated block copolymer, poly(3-hexylthiopene)-block-poly(ethylene glycol) (P3HT-b-PEG), and iron oxide nanoparticles (IONPs) at the air-water interface.	copolymer	79-88	striated muscle enriched protein kinase	Homo sapiens	146-151
35119286-0	2022	Complex pH-Dependent Interactions between Weak Polyelectrolyte Block Copolymer Micelles and Molecular Fluorophores.	copolymer	69-78	phenylalanine hydroxylase	Homo sapiens	8-10
35574763-2	2022	For this, a block copolymer of poly(N-(acryloyloxy)phthalimide) (PAP) is synthesized by straightforward reversible addition-fragmentation chain-transfer (RAFT) polymerization using a dedicated macroRAFT transfer agent.	copolymer	18-27	poly(A) polymerase alpha	Homo sapiens	65-68
35574763-3	2022	Upon decarboxylation of the PAP block, followed by efficient block copolymer cleavage, a polyethylene homopolymer with a predictable degree of polymerization is obtained.	copolymer	67-76	poly(A) polymerase alpha	Homo sapiens	28-31
35425510-3	2022	A pH-responsive copolymer was prepared and the variables of loading time, loading temperature, the amount of copolymer and also the ratio of acrylic/maleic copolymer to beta CD and the effect that these variables have on drug loading were investigated, with variable optimization studies carried out following a definitive screening design (DSD).	copolymer	16-25	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	169-176
35425298-6	2022	Thereby the copolymer with the sequence length tau = 8 is more effective in reducing the interfacial tension compared to that of diblock copolymers and the alternating copolymers at the same concentration.	copolymer	12-21	microtubule associated protein tau	Homo sapiens	47-50
35160621-7	2022	Furthermore, the viscoelastic and thermal properties of copolymer films were characterized by DMA, DSC, and TGA.	copolymer	56-65	T-box transcription factor 1	Homo sapiens	108-111
35160434-6	2022	It was shown that the gas permeability of the copolymer significantly depends on its composition, as well as on the amounts of hydroxyl and epoxy groups.	copolymer	46-55	gastrin	Homo sapiens	22-25
35160502-1	2022	A new copolymer has been studied, which is formed by Poly(2-methoxy-5-(2-ethyl-hexyloxy)-1,4-phenylene-vinylene) (MEH-PPV) and poly(3-hexylthiophene) (P3HT).	copolymer	6-15	epoxide hydrolase 1	Homo sapiens	114-117
2559918-4	1989	This ABA type block copolymer, where A is a poly(N-acetylethyleneimine) (PAEI) sequence and B a polyethylene oxide (PEO) sequence was preadsorbed at pH 4.5 and 25 degrees C; the fibrinogen adsorption was reduced to less than 5% of the value observed on untreated solid surfaces.	copolymer	20-29	fibrinogen beta chain	Homo sapiens	178-188
2533187-3	1989	The most effective of these materials is a random basic copolymer of alanine, glutamic acid, lysine and tyrosine, denoted COP 1.	copolymer	56-65	COP1 E3 ubiquitin ligase	Homo sapiens	122-127
2479428-0	1989	Identification of vitronectin as a major plasma protein adsorbed on polymer surfaces of different copolymer composition.	copolymer	98-107	vitronectin	Homo sapiens	18-29
2711904-4	1989	The authors report their experience with 150 cases of discectomies performed with interbody grafts using a copolymer (Biocompatible Orthopedic Polymer or BOP).	copolymer	107-116	BOP	Homo sapiens	154-157
2561629-4	1989	The combination consisting of 0.3% triclosan/2% PVM/MA copolymer/1100 ppm NaF was found to be highly effective on reducing smooth and fissure caries, and plaque extent compared to to 1100 ppm/NaF by itself in rats when applied topically.	copolymer	55-64	C-X-C motif chemokine ligand 8	Homo sapiens	192-195
2543564-5	1989	Parallel pelleting experiments revealed, however, that the process of polymer formation is biphasic and only at higher concentrations of caldesmon does the copolymer contain around one caldesmon/three actin monomers.	copolymer	156-165	caldesmon 1	Homo sapiens	137-146
2543564-5	1989	Parallel pelleting experiments revealed, however, that the process of polymer formation is biphasic and only at higher concentrations of caldesmon does the copolymer contain around one caldesmon/three actin monomers.	copolymer	156-165	caldesmon 1	Homo sapiens	185-194
2726457-1	1989	Physical properties of the DNA duplex, poly(dA).poly(dT) differ considerably from the alternating copolymer poly(dAT).	copolymer	98-107	Dopamine transporter	Drosophila melanogaster	113-116
2462252-0	1988	Specific inhibition of the T-cell response to myelin basic protein by the synthetic copolymer Cop 1.	copolymer	84-93	myelin basic protein	Homo sapiens	46-66
2462252-0	1988	Specific inhibition of the T-cell response to myelin basic protein by the synthetic copolymer Cop 1.	copolymer	84-93	COP1 E3 ubiquitin ligase	Homo sapiens	94-99
2462252-1	1988	Cop 1 is a synthetic basic random copolymer of L-alanine, L-glutamic acid, L-lysine, and L-tyrosine in a residue molar ratio of 6.0:1.9:4.7:1.0 and with a molecular weight of 21,000 which proved to be effective in specific suppression of experimental allergic encephalomyelitis and has been proposed as a candidate drug against multiple sclerosis.	copolymer	34-43	COP1 E3 ubiquitin ligase	Homo sapiens	0-5
3170684-1	1988	The polymeric reversed-phase packing material, PRP-1, a macroporous copolymer of styrene and divinylbenzene has been used for the liquid chromatographic analysis of proteins, peptides, oligonucleotides, pharmaceuticals and other biologically active materials.	copolymer	68-77	prion protein	Homo sapiens	47-50
2972556-6	1988	Retinal IGF-I and insulin receptors possess kinase activity towards their own beta-subunits, a tyrosine containing copolymer, and various molecular forms and subunits of transducin (T alpha-GDP, T alpha-GTP, T beta).	copolymer	115-124	insulin like growth factor 1	Bos taurus	8-13
3143185-8	1988	Trypsin-albumin copolymer bound specifically the blood serum u-PA inhibitors and the fraction adsorbed was electrophoretically characterized as a protein with molecular mass of 185 kDa.	copolymer	16-25	plasminogen activator, urokinase	Homo sapiens	61-65
2419385-0	1986	Soluble copolymer of wasp venom with human albumin for venom immunotherapy.	copolymer	8-17	WASP actin nucleation promoting factor	Homo sapiens	21-25
2445212-5	1987	The copolymer of beta hCG and MDP administered with Al(OH)3 to mice induced a high anti-beta hCG response, better than that induced by the conjugate of beta hCG to tetanus toxoid given with Al(OH)3.	copolymer	4-13	chorionic gonadotropin subunit beta 5	Homo sapiens	22-25
2445212-5	1987	The copolymer of beta hCG and MDP administered with Al(OH)3 to mice induced a high anti-beta hCG response, better than that induced by the conjugate of beta hCG to tetanus toxoid given with Al(OH)3.	copolymer	4-13	chorionic gonadotropin subunit beta 5	Homo sapiens	93-96
2445212-5	1987	The copolymer of beta hCG and MDP administered with Al(OH)3 to mice induced a high anti-beta hCG response, better than that induced by the conjugate of beta hCG to tetanus toxoid given with Al(OH)3.	copolymer	4-13	chorionic gonadotropin subunit beta 5	Homo sapiens	93-96
2445212-7	1987	Even more interesting, a copolymer of beta hCG and of murabutide induced high levels of biologically active antibodies.	copolymer	25-34	chorionic gonadotropin subunit beta 5	Homo sapiens	43-46
3593791-2	1987	It was shown that only tN-DSK effectively produces with fibrinogen soluble and insoluble forms of the copolymer characterized by a constant stoichiometry which, in turn, reflects its regular structure.	copolymer	102-111	fibrinogen beta chain	Homo sapiens	56-66
6189942-3	1983	The copolymer L-glutamic acid50-L-tyrosine50 (GT) completely inhibits the response of L-glutamic acid60-L-alanine40-L-tyrosine10 (GAT)-specific, I-Ad-restricted T cell hybridomas to GAT plus accessory cells.	copolymer	4-13	glycine-N-acyltransferase	Homo sapiens	86-128
2935880-1	1986	Lipophilic anionic copolymer (styrene-maleic acid; SMA) conjugates of albumin and antitumor protein neocarzinostatin (NCS) (smancs) were found to stimulate the release of H2O2 and O-2 from the peritoneal macrophages obtained from mice which had been pretreated with the heat-killed preparation of Streptococcus pyogenes (OK-432) in vivo.	copolymer	19-28	immunoglobulin mu binding protein 2	Mus musculus	51-54
4030968-3	1985	A water-soluble linear copolymer supporting procainamide, a ligand of the anionic site of cholinesterase, was physically entrapped at various concentrations within the gel network.	copolymer	23-32	butyrylcholinesterase	Homo sapiens	90-104
6202427-1	1984	The synthetic random copolymer poly( Glu60 , Phe40 ) ( GPhe ) is an excellent immunogen in SWR/J (H-2q) mice.	copolymer	21-30	histocompatibility 2, Q region	Mus musculus	98-102
2983990-2	1985	In partially purified receptor preparations from eight different tissues insulin best stimulated (highest V) phosphorylation of a random copolymer composed of glutamic and tyrosine residues at a 4:1 ratio (Glu/Tyr, 4:1).	copolymer	137-146	insulin	Homo sapiens	73-80
2998590-4	1985	Pyran copolymer-induced peritoneal cells endowed the tumour vaccine-primed mice, but not unprimed mice, with resistance to implanted L1210 and, among those peritoneal cell populations, macrophages but not T cells were responsible for this effect since the activity was associated with a cell population which was adherent to nylon wool columns, sensitive to silica and insensitive to anti-Thy 1.2 antibody plus complement.	copolymer	6-15	thymus cell antigen 1, theta	Mus musculus	389-396
6189942-3	1983	The copolymer L-glutamic acid50-L-tyrosine50 (GT) completely inhibits the response of L-glutamic acid60-L-alanine40-L-tyrosine10 (GAT)-specific, I-Ad-restricted T cell hybridomas to GAT plus accessory cells.	copolymer	4-13	glycine-N-acyltransferase	Homo sapiens	130-133
6189942-3	1983	The copolymer L-glutamic acid50-L-tyrosine50 (GT) completely inhibits the response of L-glutamic acid60-L-alanine40-L-tyrosine10 (GAT)-specific, I-Ad-restricted T cell hybridomas to GAT plus accessory cells.	copolymer	4-13	glycine-N-acyltransferase	Homo sapiens	182-185
289438-4	1979	Simultaneous treatment of MI cells with the anti-interferon serum and copolymer of polyinosine and polycytidylic acids and D-factor abolished the enhancing effect of copolymer of polyinosine and polycytidylic acids on the action of the D-factor.	copolymer	70-79	leukemia inhibitory factor	Mus musculus	236-244
6988213-5	1980	Immobilization of NADH onto this copolymer was accomplished in three steps, namely, alkylation of NAD at N-1, reduction of the nicotinamide moiety with dithionite and Dimroth rearrangement of the alkyl linkage from the N-1 to the C-6 amino position.	copolymer	33-42	complement C6	Homo sapiens	230-233
6988213-7	1980	Using this copolymer, immobilization of NADH through the adenine C-6 amino position was accomplished in a single step.	copolymer	11-20	complement C6	Homo sapiens	65-68
289438-4	1979	Simultaneous treatment of MI cells with the anti-interferon serum and copolymer of polyinosine and polycytidylic acids and D-factor abolished the enhancing effect of copolymer of polyinosine and polycytidylic acids on the action of the D-factor.	copolymer	166-175	leukemia inhibitory factor	Mus musculus	123-131
289438-4	1979	Simultaneous treatment of MI cells with the anti-interferon serum and copolymer of polyinosine and polycytidylic acids and D-factor abolished the enhancing effect of copolymer of polyinosine and polycytidylic acids on the action of the D-factor.	copolymer	166-175	leukemia inhibitory factor	Mus musculus	236-244
473117-3	1979	The antithrombin activity of the copolymer corresponded to 1% of grafted heparin.	copolymer	33-42	serpin family C member 1	Homo sapiens	4-16
473117-4	1979	PMMA sequence of the copolymer played the leading role in fibrinogen, immunoglobulins, transferrin and albumin adsorption.	copolymer	21-30	fibrinogen beta chain	Homo sapiens	58-68
473117-4	1979	PMMA sequence of the copolymer played the leading role in fibrinogen, immunoglobulins, transferrin and albumin adsorption.	copolymer	21-30	transferrin	Homo sapiens	87-98
473117-5	1979	These proteins adsorbed on the copolymer, showed different competitive desorption pattern in the presence of whole plasma: fibrinogen presented the highest degree of affinity for the copolymer.	copolymer	31-40	fibrinogen beta chain	Homo sapiens	123-133
473117-5	1979	These proteins adsorbed on the copolymer, showed different competitive desorption pattern in the presence of whole plasma: fibrinogen presented the highest degree of affinity for the copolymer.	copolymer	183-192	fibrinogen beta chain	Homo sapiens	123-133
473117-6	1979	The heparin part of the copolymer was responsible for antithrombin III adsorption and for decrease of factor V activity.	copolymer	24-33	serpin family C member 1	Homo sapiens	54-70
853045-4	1977	After contact with plasma, the copolymer lost part of its antithrombin activity which could be restored by a high ionic-strength medium.	copolymer	31-40	serpin family C member 1	Homo sapiens	58-70
4741155-0	1973	Polymerization of DL-phenylalanine NCA initiated by copolymer of sarcosine and DL-phenylalanine.	copolymer	52-61	CEA cell adhesion molecule 6	Homo sapiens	35-38
932641-2	1976	Mapping of H-2 complex complementing genes controlling immune suppression by the random copolymer L-glutamic acid50-L-tyrosine50 (GT).	copolymer	88-97	histocompatibility-2, MHC	Mus musculus	11-14
766630-2	1976	Iodinated hormone was prepared with the use of the chloramine-T method, and antibodies were developed in rabbits over a six-month period with a GnRH synthetic copolymer immunogen.	copolymer	159-168	gonadotropin releasing hormone 1	Homo sapiens	144-148
4899881-7	1969	The compound was shown to be incorporated enzymatically into dAT copolymer to the extent of about one molecule per molecule of template.	copolymer	65-74	Dopamine transporter	Drosophila melanogaster	61-64
5648278-0	1968	Statistics of branching and hairpin helices for the dAT copolymer.	copolymer	56-65	Dopamine transporter	Drosophila melanogaster	52-55
5745507-3	1968	One catalyzes the dAT (copolymer of deoxyadenylate and deoxythymidylate)-primed conversion of adenosine triphosphate and uridine triphosphate into an acid-insoluble product.	copolymer	23-32	Dopamine transporter	Drosophila melanogaster	18-21
33876979-1	2021	A pair of ATR IR spectra obtained during the crystallization of bioplastic copolymer poly[(R)-3-hydroxybutyrate-co-(R)-3-hydroxyhexanoate] or PHBHx from the melt by spontaneous cooling were examined using the two-trace two-dimensional correlation spectroscopy (2T2D-COS) analysis.	copolymer	75-84	ATR serine/threonine kinase	Homo sapiens	10-13
33389648-0	2021	DDAB cationic lipid-mPEG, PCL copolymer hybrid nano-carrier synthesis and application for delivery of siRNA targeting IGF-1R into breast cancer cells.	copolymer	30-39	insulin like growth factor 1 receptor	Homo sapiens	118-124
33740633-0	2021	A novel "smart" PNIPAM-based copolymer for breast cancer targeted therapy: Synthesis, and characterization of dual pH/temperature-responsive lactoferrin-targeted PNIPAM-co-AA.	copolymer	29-38	lactotransferrin	Mus musculus	141-152
33872001-9	2021	In an air pouch model of acute local inflammation, the optimized copolymer outperformed both the free drug and a 100% poly(TEMPO) formulation in O2 - scavenging, retention, and reduction of TNFalpha levels.	copolymer	65-74	tumor necrosis factor	Homo sapiens	190-198
34031970-4	2021	In this study, nanoparticles composed of novel PEGylated alternating copolymer-CA4 conjugates are designed to improve the therapeutic efficiency of CA4.	copolymer	69-78	carbonic anhydrase 4	Mus musculus	79-82
34031970-4	2021	In this study, nanoparticles composed of novel PEGylated alternating copolymer-CA4 conjugates are designed to improve the therapeutic efficiency of CA4.	copolymer	69-78	carbonic anhydrase 4	Mus musculus	148-151
34014640-0	2021	Buried Structure in Block Copolymer Films Revealed by Soft X-ray Reflectivity.	copolymer	26-35	POC1 centriolar protein A	Homo sapiens	54-58
33942499-1	2021	In this study a histidine containing elastin-like polypeptide (ELP) diblock copolymer is described with multiresponsive assembly behavior.	copolymer	76-85	nuclear receptor subfamily 5 group A member 1	Homo sapiens	37-61
33942499-1	2021	In this study a histidine containing elastin-like polypeptide (ELP) diblock copolymer is described with multiresponsive assembly behavior.	copolymer	76-85	nuclear receptor subfamily 5 group A member 1	Homo sapiens	63-66
33373606-11	2021	This work suggested that star-like amphiphilic Suc-OBF(TGA)-SS-PEG copolymer micelles may provide a promising platform for delivering doxorubicin and other hydrophobic anticancer drugs.	copolymer	67-76	izumo sperm-egg fusion 1	Homo sapiens	51-54
33898875-3	2021	Herein, a cyclodextrin-cored star copolymer nanoparticle system (sCDP/DOX/miR-122) is constructed to co-deliver miR-122 with doxorubicin (DOX) for hepatoma therapy.	copolymer	34-43	microRNA 122	Homo sapiens	74-81
33899561-1	2021	In this experiment, a new amphiphilic chitosan-poly(lactide) graft copolymer was synthesized and characterized by IR, 1H-NMR, XRD, TGA.	copolymer	67-76	T-box transcription factor 1	Homo sapiens	131-134
33919756-3	2021	However, both the synthesis of PLCL and the structure-activity relationship of the copolymer need to be further investigated to allow tuning of different mechanical properties.	copolymer	83-92	phospholipase C like 1 (inactive)	Homo sapiens	31-35
33755416-6	2021	The copolymer composition, i.e., NCE to EP ratio, has found to have profound impacts on the resin flowability, thermomechanical properties, moisture absorption, and dielectric properties, which are discussed in this paper with in-depth analysis on their structure-property relationships.	copolymer	4-13	epiregulin	Homo sapiens	40-42
33898875-3	2021	Herein, a cyclodextrin-cored star copolymer nanoparticle system (sCDP/DOX/miR-122) is constructed to co-deliver miR-122 with doxorubicin (DOX) for hepatoma therapy.	copolymer	34-43	microRNA 122	Homo sapiens	112-119
32997426-0	2021	Effect of hydrophilic monomer distribution on self-assembly of a pH-responsive copolymer: Spheres, worms and vesicles from a single copolymer composition.	copolymer	79-88	phenylalanine hydroxylase	Homo sapiens	65-67
33661006-0	2021	Programmable Morphology Evolution of Rod-Coil-Rod Block Copolymer Assemblies Induced by Variation of Chain Ordering.	copolymer	56-65	kinetochore associated 1	Homo sapiens	37-40
33661006-0	2021	Programmable Morphology Evolution of Rod-Coil-Rod Block Copolymer Assemblies Induced by Variation of Chain Ordering.	copolymer	56-65	kinetochore associated 1	Homo sapiens	46-49
33601885-0	2021	Long-Lasting Bioluminescence Imaging of the Fibroblast Activation Protein by an Amphiphilic Block Copolymer-Based Probe.	copolymer	98-107	fibroblast activation protein alpha	Homo sapiens	44-73
33601885-4	2021	For this purpose, an amphiphilic block copolymer containing an FAP-responsive peptide was fabricated to self-assemble into micelles, which act as a depot to load amounts of d-luciferin for constructing the BL probe.	copolymer	39-48	fibroblast activation protein alpha	Homo sapiens	63-66
32997426-3	2021	In particular, a diblock copolymer consisting of two random copolymer segments of equal length (16 mol% and 84 mol% AA respectively) formed spherical micelles at pH > 5, a mix of spherical and worm-like micelles at pH 5 and vesicles at pH 4.	copolymer	25-34	phenylalanine hydroxylase	Homo sapiens	162-164
32997426-0	2021	Effect of hydrophilic monomer distribution on self-assembly of a pH-responsive copolymer: Spheres, worms and vesicles from a single copolymer composition.	copolymer	132-141	phenylalanine hydroxylase	Homo sapiens	65-67
32997426-3	2021	In particular, a diblock copolymer consisting of two random copolymer segments of equal length (16 mol% and 84 mol% AA respectively) formed spherical micelles at pH > 5, a mix of spherical and worm-like micelles at pH 5 and vesicles at pH 4.	copolymer	25-34	phenylalanine hydroxylase	Homo sapiens	215-217
32997426-3	2021	In particular, a diblock copolymer consisting of two random copolymer segments of equal length (16 mol% and 84 mol% AA respectively) formed spherical micelles at pH > 5, a mix of spherical and worm-like micelles at pH 5 and vesicles at pH 4.	copolymer	25-34	phenylalanine hydroxylase	Homo sapiens	215-217
33499588-3	2021	As the third component, ITIC building blocks with a larger pi-conjugation structure, shorter solubilizing side chains, and red-shifted absorption spectrum were incorporated into an IDIC16-based nonconjugated copolymer acceptor PF1-TS4, which built up the terpolymers with two conjugated building blocks linked by flexible thioalkyl chain-thiophene segments.	copolymer	208-217	PHD finger protein 12	Homo sapiens	227-230
33068897-0	2021	Fluorescence copolymer-based dual-signal monitoring tyrosinase activity and its inhibitor screening via blue-green emission transformation.	copolymer	13-22	tyrosinase	Homo sapiens	52-62
33568710-4	2021	The results show that, at a fixed PPG/PEG ratio, block copolymers have larger two-phase region compared with random copolymer.	copolymer	55-64	serglycin	Homo sapiens	34-37
33068897-2	2021	Herein, a dual-signal fluorescence sensing system for monitoring TYR activity is constructed depending on the transformation of blue-green fluorescence emission of copolymer.	copolymer	164-173	tyrosinase	Homo sapiens	65-68
33068897-3	2021	The developed sensing system is based on TYR catalyzing the hydroxylation of mono-phenol to o-diphenol and the conversion of fluorescence copolymer (FCP) blue emission (430 nm) and green emission (535 nm) in the presence of PEI.	copolymer	138-147	tyrosinase	Homo sapiens	41-44
32418316-6	2021	Moreover, the copolymer was able to induce lysosome membrane permeation (LMP) and increase Rh123 accumulation inside cells indicating inhibition of the P-gp efflux pumps.	copolymer	14-23	phosphoglycolate phosphatase	Homo sapiens	152-156
33226777-4	2021	A set of copolymer-PEG solubilizers is synthesized by controlled radical polymerization, systematically altering the length of the functional segment (DPn = 2, 4, 6) and the side chain functionalization (iBuMA, iPrMA, MeMA).	copolymer	9-18	pinin, desmosome associated protein	Homo sapiens	218-222
33219887-1	2020	We studied the effects of repeated injections of methylprednisolone and its micellar complex with block-copolymer on locomotor activity of a terrestrial snail.	copolymer	104-113	snail family transcriptional repressor 1	Homo sapiens	153-158
32656667-2	2020	To harvest hMSCs from MCs without using proteolytic enzyme treatment but by lowering temperature, polystyrene MCs coated with a copolymer called CAT having zwitterionic and thermoresponsive characteristics, which has a lower critical solution temperature (LCST) in the range of 28-32 C, were developed and compared with those coated with poly(N-isopropylacrylamide) (PNIPAM), which has an LCST almost the same as that of the CAT copolymer.	copolymer	128-137	catalase	Homo sapiens	145-148
32656667-2	2020	To harvest hMSCs from MCs without using proteolytic enzyme treatment but by lowering temperature, polystyrene MCs coated with a copolymer called CAT having zwitterionic and thermoresponsive characteristics, which has a lower critical solution temperature (LCST) in the range of 28-32 C, were developed and compared with those coated with poly(N-isopropylacrylamide) (PNIPAM), which has an LCST almost the same as that of the CAT copolymer.	copolymer	128-137	catalase	Homo sapiens	425-428
32693292-3	2020	The copolymer PPO is mixed with LiTFSI and LLZTO at different ratios and the Li conductivity and other electrochemical properties were studied.	copolymer	4-13	protoporphyrinogen oxidase	Homo sapiens	14-17
33373170-0	2021	Au-Polyoxometalates A-B-A-B Type Copolymer-Analogue Sub-1 nm Nanowires.	copolymer	33-42	SUB1 regulator of transcription	Homo sapiens	52-57
32852145-2	2020	Here, hypoxia-activated self-immolative paclitaxel prodrug (PTX 2 -Azo) was synthesized and combined with photodynamic therapy (PDT) to prepare light-boosted PTX nanoparticle (Ce6/PTX 2 -Azo NP) by encapsulation PTX 2 -Azo into photosensitizer chlorine (Ce6) decorated peptide copolymer.	copolymer	277-286	paired like homeodomain 2	Homo sapiens	60-65
33045320-7	2020	As demonstrated by the release of highly bioactive vascular endothelial growth factor, formulations of this copolymer are suitable for prolonged delivery of protein therapeutics.	copolymer	108-117	vascular endothelial growth factor A	Homo sapiens	51-85
32786529-5	2020	The activity of the BChE-polymer-oxime conjugates was dependent on the degree of oxime loading within the copolymer side chains.	copolymer	106-115	butyrylcholinesterase	Homo sapiens	20-24
32930567-3	2020	In this work, we reported a stable hydrogel electrolyte, fabricated by coupling the grafted copolymer xanthan gum-polyacrylamide (XG-PAM) with cotton cellulose nanofiber (CNF), denoted as XG-PAM/CNF.	copolymer	92-101	NPHS1 adhesion molecule, nephrin	Homo sapiens	171-174
32505754-5	2020	In contrast, TRAIL gene delivered by the autophagy-blocking-deficient control copolymer without the chlorine atom presents weaker antitumor efficacy, although expressing a similar amount of therapeutic TRAIL protein.	copolymer	78-87	TNF superfamily member 10	Homo sapiens	13-18
32679269-1	2020	HPMA copolymer-based dexamethasone prodrug (P-Dex) and PEG-based dexamethasone prodrug (PEG-Dex, ZSJ-0228) were previously found to passively target the inflamed kidney and provide potent and sustained resolution of nephritis in NZB/WF1 lupus-prone mice.	copolymer	5-14	TP53 regulated inhibitor of apoptosis 1	Mus musculus	233-236
32806310-8	2020	A decreased crystallinity and increased hydrophilicity of the graft copolymer, concerning the PHB, was found.	copolymer	68-77	prohibitin 1	Homo sapiens	94-97
33001126-6	2020	The PCL-ss-P(PEGMA-co-GHA) amphiphilic copolymer could self-assemble into nanoparticles, which could be used to encapsulate anticancer drug doxorubicin (DOX) and compress the p53 gene to form the DOX-loaded PCL-ss-P(PEGMA-co-GHA)/p53 complex (abbreviated as DPGHAP/p53).	copolymer	39-48	tumor protein p53	Homo sapiens	175-178
33001126-6	2020	The PCL-ss-P(PEGMA-co-GHA) amphiphilic copolymer could self-assemble into nanoparticles, which could be used to encapsulate anticancer drug doxorubicin (DOX) and compress the p53 gene to form the DOX-loaded PCL-ss-P(PEGMA-co-GHA)/p53 complex (abbreviated as DPGHAP/p53).	copolymer	39-48	tumor protein p53	Homo sapiens	230-233
33001126-6	2020	The PCL-ss-P(PEGMA-co-GHA) amphiphilic copolymer could self-assemble into nanoparticles, which could be used to encapsulate anticancer drug doxorubicin (DOX) and compress the p53 gene to form the DOX-loaded PCL-ss-P(PEGMA-co-GHA)/p53 complex (abbreviated as DPGHAP/p53).	copolymer	39-48	tumor protein p53	Homo sapiens	258-269
32816457-6	2020	We report di-block copolymer of tryptophan-functionalized methacrylic acid (PTMA) polyampholyte synthesized through reversible addition fragmentation chain transfer (RAFT) polymerization.	copolymer	19-28	prothymosin alpha	Homo sapiens	76-80
32498278-4	2020	Furthermore, the copolymer was functionalized with the peptide ligand GE11 targeting the epidermal growth factor receptor, EGFR.	copolymer	17-26	epidermal growth factor receptor	Homo sapiens	89-121
32589696-5	2020	Herein, a biodegradable conductive block copolymer, tetraaniline-b-polycaprolactone-b-tetraaniline (TPT), is synthesised and 3D printed for the first time into porous scaffolds with defined geometries.	copolymer	41-50	decaprenyl diphosphate synthase subunit 1	Homo sapiens	52-98
32589696-5	2020	Herein, a biodegradable conductive block copolymer, tetraaniline-b-polycaprolactone-b-tetraaniline (TPT), is synthesised and 3D printed for the first time into porous scaffolds with defined geometries.	copolymer	41-50	decaprenyl diphosphate synthase subunit 1	Homo sapiens	100-103
33029079-1	2020	1"-(2-Acryloxyethyl)-3,3"-dimethyl-6-nitrospiro[2 H-1-benzopyran-2,2"-indoline] (SPA) was synthesized and grafted onto a water-soluble carboxymethyl chitin (CMCH) macromolecule to prepare a photochromic copolymer (CMCH-g-SPA).	copolymer	203-212	surfactant protein A1	Homo sapiens	81-84
32378308-5	2020	In addition, we have applied post-polymerization modification to the covalent linking of a photocaged cyclic antibiotic (Gramicidin S) to the side chains of the KAT-containing copolymer.	copolymer	176-185	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	161-164
32863801-0	2020	Lactoferrin-Loaded PEG/PLA Block Copolymer Targeted With Anti-Transferrin Receptor Antibodies for Alzheimer Disease.	copolymer	33-42	transferrin	Homo sapiens	62-73
33094280-7	2020	In M20 mice, unilateral hippocampal injection of alpha-synuclein fibrils or tau fibrils induced robust bilateral phosphorylated alpha-synuclein pathology, while tau + alpha-synuclein copolymer injection resulted in restricted phosphorylated alpha-synuclein pathology predominantly in the ipsilateral cortex.	copolymer	183-192	synuclein, alpha	Mus musculus	49-64
32629765-3	2020	According to the data of elemental analysis, FTIR-spectroscopy, X-ray photoelectron spectroscopy and thermal analysis these IPCs have excess of anionic copolymer (Eudragit  S100) in their structure; they are stabilized by hydrogen and ionic intermacromolecular bonds and do not include free copolymer domains.	copolymer	152-161	S100 calcium binding protein A1	Homo sapiens	173-177
32453943-0	2020	PEG/PPG-PDMS-based Crosslinked Copolymer Membranes Prepared by ROMP and in situ Membrane Casting for CO2 Separation: an approach to endow rubbery materials with properties of rigid polymers.	copolymer	31-40	serglycin	Homo sapiens	4-7
32404554-2	2020	The key features of random copolymer self-assemblies are 1) selffolding of polymer chains, 2) precision self-assembly of side chains, and 3) dynamic self-sorting and selective recognition.	copolymer	27-36	VPS52 subunit of GARP complex	Homo sapiens	53-58
32498278-4	2020	Furthermore, the copolymer was functionalized with the peptide ligand GE11 targeting the epidermal growth factor receptor, EGFR.	copolymer	17-26	epidermal growth factor receptor	Homo sapiens	123-127
32378131-11	2020	The conclusions are in qualitative agreement with experimental data showing high selectivity towards copolymer formation in the copolymerization processes catalyzed by bifunctional Co(III) salen-complexes.	copolymer	101-110	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	181-188
32353997-0	2020	Facilitated Structure Formation in Isoporous Block Copolymer Membranes upon Controlled Evaporation by Gas Flow.	copolymer	51-60	gastrin	Homo sapiens	102-105
32197572-0	2020	Electrochemical quartz crystal microbalance with dissipation investigation of fibronectin adsorption dynamics driven by electrical stimulation onto a conducting and partially biodegradable copolymer.	copolymer	189-198	fibronectin 1	Mus musculus	78-89
32216370-0	2020	Spatial Distribution of PEO-PPO-PEO Block Copolymer and PEO Homopolymer in Lipid Bilayers.	copolymer	42-51	twinkle mtDNA helicase	Homo sapiens	24-27
32216370-0	2020	Spatial Distribution of PEO-PPO-PEO Block Copolymer and PEO Homopolymer in Lipid Bilayers.	copolymer	42-51	twinkle mtDNA helicase	Homo sapiens	32-35
32216370-0	2020	Spatial Distribution of PEO-PPO-PEO Block Copolymer and PEO Homopolymer in Lipid Bilayers.	copolymer	42-51	twinkle mtDNA helicase	Homo sapiens	32-35
32173261-3	2020	Herein, we prepare a MFG-E8-loaded copolymer system-based anti-inflammation therapy for SCI treatment.	copolymer	35-44	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	21-27
32125062-1	2020	The periodic twist behaviors of amyloid fibrils initiated and formed on block copolymer films with nanoscale features are studied.	copolymer	78-87	twist family bHLH transcription factor 1	Homo sapiens	13-18
32210118-2	2020	The copolymer, denoted as SX-1, was characterized by FT-IR, TGA-DSC, and GPC.	copolymer	4-13	T-box transcription factor 1	Homo sapiens	60-63
32210118-2	2020	The copolymer, denoted as SX-1, was characterized by FT-IR, TGA-DSC, and GPC.	copolymer	4-13	glycophorin C (Gerbich blood group)	Homo sapiens	73-76
32197572-7	2020	Additionally, FN binds to the copolymer interface in an unfolded conformation, which can promote better NIH-3T3 fibroblast cell adhesion and later cell development.	copolymer	30-39	fibronectin 1	Mus musculus	14-16
31923958-2	2020	To this end, we constructed a novel UV-light cross-linked and pH de-cross-linked coumarin-decorated cationic copolymer functionalized mesoporous silica nanoparticles (MSN) for co-delivery of chemotherapeutic agent 5-FU and tumor suppresser p53 gene.	copolymer	109-118	tumor protein p53	Homo sapiens	240-243
32103941-4	2020	An amphiphilic block copolymer N-acetyl-d-glucosamine(NAG)-poly(styrene-alt-maleic anhydride)58-b-polystyrene130 acted as a targeting moiety and emulsifier in formation of nanostructures (NLCs).	copolymer	21-30	neuroblastoma amplified sequence	Mus musculus	54-57
31977118-0	2020	A Facile and Highly Efficient Route to Amphiphilic Star-Like Rod-Coil Block Copolymer via a Combination of Atom Transfer Radical Polymerization with Thiol-Ene Click Chemistry.	copolymer	76-85	steroidogenic acute regulatory protein	Homo sapiens	51-55
31704343-2	2020	To overcome these drawbacks, a novel erythrocyte-cancer cell hybrid membrane camouflaged pH-responsive copolymer micelle (dextran-grafted-poly (histidine) copolymer) was prepared to target deliver a selective CSF-1R inhibitor: BLZ-945 (shorten as DH@ECm) to TAMs for TAMs depletion.	copolymer	103-112	colony stimulating factor 1 receptor	Homo sapiens	209-215
31835183-2	2020	BR nanodiscs were synthesized by solubilizing purple membrane in discoidal phospholipid bilayer stabilized by amphipathic Styrene-Maleic Acid (SMA) copolymer.	copolymer	148-157	chromosome 12 open reading frame 73	Homo sapiens	0-2
31970547-6	2020	The functionalization of the block copolymer carriers with a targeting folate group enhanced the tumor cell growth inhibition and total apoptotic rates induced by CytC.	copolymer	35-44	cytochrome c, somatic	Homo sapiens	163-167
31769963-3	2019	Here, we report a novel biodegradable copolymer to codeliver LY2109761 (a TGF-beta receptor I/II inhibitor) and CPI-613 (a novel chemotherapy agent) to desmoplastic stroma and tumor cells, respectively, in the tumor microenvironment.	copolymer	38-47	transforming growth factor, beta receptor II	Mus musculus	74-96
33012880-7	2020	Hydrolytic degradation analysis showed rapid degradation of copolymer in formulation containing higher chain length of CS (200 kDa)-zinc-insulin complexes, implying formation of bigger pores and channels in copolymeric matrix during initial release in this system.	copolymer	60-69	citrate synthase	Homo sapiens	119-121
33012880-7	2020	Hydrolytic degradation analysis showed rapid degradation of copolymer in formulation containing higher chain length of CS (200 kDa)-zinc-insulin complexes, implying formation of bigger pores and channels in copolymeric matrix during initial release in this system.	copolymer	60-69	insulin	Homo sapiens	137-144
31756283-4	2019	PPO-GP, is a di-block copolymer with PPO and beta-galactose polypeptide, exhibits lower critical solution temperature and is entrapped within the scaffold through hydrophobic interactions.	copolymer	22-31	protoporphyrinogen oxidase	Homo sapiens	0-3
31769963-4	2019	Hydrophobic CPI-613 is conjugated to the hydrophilic copolymer via a newly designed MMP-2-responsive linker to form a trigger-responsive nanopolyplex.	copolymer	53-62	matrix metallopeptidase 2	Mus musculus	84-89
31472313-2	2019	Hierarchical strand networks of hydrophobic PS/PB blocks anchored via PEO blocks to the water surface, with an internal phase-separation structure consisting of periodic domains of PS blocks surrounded and connected by a matrix of PB blocks, are generated by the interplay of interfacial amphiphilic block copolymer aggregation and polymer/polymer phase separation.	copolymer	306-315	surfactant protein B	Homo sapiens	44-49
31472313-2	2019	Hierarchical strand networks of hydrophobic PS/PB blocks anchored via PEO blocks to the water surface, with an internal phase-separation structure consisting of periodic domains of PS blocks surrounded and connected by a matrix of PB blocks, are generated by the interplay of interfacial amphiphilic block copolymer aggregation and polymer/polymer phase separation.	copolymer	306-315	surfactant protein B	Homo sapiens	44-46
31472313-2	2019	Hierarchical strand networks of hydrophobic PS/PB blocks anchored via PEO blocks to the water surface, with an internal phase-separation structure consisting of periodic domains of PS blocks surrounded and connected by a matrix of PB blocks, are generated by the interplay of interfacial amphiphilic block copolymer aggregation and polymer/polymer phase separation.	copolymer	306-315	surfactant protein B	Homo sapiens	47-49
31382833-4	2019	METHODS: A tumor suppressor gene GRIM-19 was delivered by an amphiphilic copolymer consisted of Poly(epsilon-caprolactone) and ethanolamine-functionalized poly (glycidyl methacrylate) (PCG).	copolymer	73-82	NADH:ubiquinone oxidoreductase subunit A13	Mus musculus	33-40
31436780-5	2019	By changing the hydrophilic-hydrophobic balance in the copolymer, anti-VEGF release rates can be modulated.	copolymer	55-64	vascular endothelial growth factor A	Rattus norvegicus	71-75
31382833-4	2019	METHODS: A tumor suppressor gene GRIM-19 was delivered by an amphiphilic copolymer consisted of Poly(epsilon-caprolactone) and ethanolamine-functionalized poly (glycidyl methacrylate) (PCG).	copolymer	73-82	psoriasis susceptibility 1 candidate 2 (human)	Mus musculus	185-188
31442510-3	2019	The grafted copolymer was characterized by FTIR, TGA and SEM tools.	copolymer	12-21	T-box transcription factor 1	Homo sapiens	49-52
31501424-2	2019	Here we report the generation of block copolymer Moebius strips via a fast self-assembly of chiral block copolymer polystyrene-block-poly(D-lactide acid) (PS-b-PDLA) in tetrahydrofuran/water mixed solvents.	copolymer	39-48	PDON2	Homo sapiens	160-164
31494237-7	2019	This also transferred to greater DNA damage, more apoptosis and superior cytotoxicity (2.4-fold) of doxorubicin which was chosen as the model drug and attached to SVS-1 modified HPMA copolymer (SVS-1-P-DOX).	copolymer	183-192	amine oxidase copper containing 1-like 3	Mus musculus	163-168
31494237-7	2019	This also transferred to greater DNA damage, more apoptosis and superior cytotoxicity (2.4-fold) of doxorubicin which was chosen as the model drug and attached to SVS-1 modified HPMA copolymer (SVS-1-P-DOX).	copolymer	183-192	amine oxidase copper containing 1-like 3	Mus musculus	194-199
31339220-1	2019	Polyoligosiloxysilicone (POSiSil; designated PSS-2) is a copolymer of double four-ring (D4R) cyclosilicate and dimethylsiloxane.	copolymer	57-66	phosphatidylserine synthase 2	Homo sapiens	45-50
31475270-1	2019	Synthesis of Ag2O decorated hierarchical TiO2 was realised in this study by employing a facile hydrothermal method, which involved the use of a double comb copolymer templated sol-gel and a chemical bath.	copolymer	156-165	anterior gradient 2, protein disulphide isomerase family member	Homo sapiens	13-16
31268075-3	2019	A novel copolymer mPEG-C[double bond, length as m-dash]N-PAsp(MEA)-CA was synthesized and self-assembled into a dual-sensitive interlayer-crosslinked micelle (ICM).	copolymer	8-17	carboxypeptidase B1	Homo sapiens	57-61
31404498-0	2019	Nitrogen-Doped Hollow Copolymer Tube via Template-Free Asynchronous Polymerization with Highly Selective Separation of Hydrophilic Dipeptide for Enhancing Inhibitory Activity of Angiotensin Converting Enzyme.	copolymer	22-31	LOC101737600	Bombyx mori	178-207
31411778-0	2019	Thermally Induced Reversible Self-Assembly of Apoferritin-Block Copolymer Complexes.	copolymer	64-73	ferritin heavy chain 1	Homo sapiens	46-57
31079690-8	2019	The degree of crystallinity and thermal stability of the lipase catalysed copolymer was reduced compared to unmodified chitosan.	copolymer	74-83	PAN0_003d1715	Moesziomyces antarcticus	57-63
31048243-6	2019	Copolymer concentration influenced the hemolytic profile of encapsulated HePC; for F127 the HC50 increased relative to free HePC (40 mug/mL) up to 184, 441, 736 and 964 mug/mL, for 1, 3, 6 and 9% F127, respectively.	copolymer	0-9	hepcidin antimicrobial peptide	Homo sapiens	73-77
31048243-6	2019	Copolymer concentration influenced the hemolytic profile of encapsulated HePC; for F127 the HC50 increased relative to free HePC (40 mug/mL) up to 184, 441, 736 and 964 mug/mL, for 1, 3, 6 and 9% F127, respectively.	copolymer	0-9	hepcidin antimicrobial peptide	Homo sapiens	124-128
30952291-0	2019	Electrogenerated chemiluminescence aptasensor for lysozyme based on copolymer nanospheres encapsulated black phosphorus quantum dots.	copolymer	68-77	lysozyme	Homo sapiens	50-58
31273372-3	2019	The best electric performance, including the largest Ue of 12.2 J cm-3, eta of 92%, and Eb of 530 MV m-1 at ambient temperature, was obtained in the copolymer bearing 45 mol% MMA.	copolymer	149-158	endothelin receptor type A	Homo sapiens	72-75
31054369-3	2019	The goal of this study is to develop an improved therapy that co-delivers a novel bioengineered miRNA prodrug (tRNA-mir-34a) and doxorubicin (DOX) via a multifunctional nanomicellar carrier that is based on a conjugate of amphiphilic copolymer POEG-VBC backbone with creatine, a naturally occurring cationic molecule.	copolymer	234-243	microRNA 34a	Homo sapiens	116-123
31196355-6	2019	Computer simulation results revealed a good compatibility of H6 and MPEG2k-PCL2k copolymer.	copolymer	81-90	metal response element binding transcription factor 2	Homo sapiens	75-79
31239670-1	2019	Purpose: Doxorubicin (DOX) encapsulated O-succinyl chitosan graft Pluronic  F127 (OCP) copolymer nanoparticles conjugated with an anti-HER2 monoclonal antibody were developed as targeted drug delivery vehicles for the treatment of HER2-overexpressing breast cancer.	copolymer	87-96	erb-b2 receptor tyrosine kinase 2	Homo sapiens	135-139
31005767-2	2019	An amphiphilic copolymer PAVE containing photo-cross-linkable coumarin segments and carboxylic groups was co-assembled with MWCNTs in aqueous solution while encapsulating the model enzyme namely glucose oxidase (GOx) simultaneously, generating necklace-like bio-nanocomposites (GOx@PAVE-CNTs) with GOx-loading polymeric nanoparticles as nanobeads and MWCNTs as conducting micron-string.	copolymer	15-24	hydroxyacid oxidase 1	Homo sapiens	195-210
31005767-2	2019	An amphiphilic copolymer PAVE containing photo-cross-linkable coumarin segments and carboxylic groups was co-assembled with MWCNTs in aqueous solution while encapsulating the model enzyme namely glucose oxidase (GOx) simultaneously, generating necklace-like bio-nanocomposites (GOx@PAVE-CNTs) with GOx-loading polymeric nanoparticles as nanobeads and MWCNTs as conducting micron-string.	copolymer	15-24	hydroxyacid oxidase 1	Homo sapiens	212-215
31005767-2	2019	An amphiphilic copolymer PAVE containing photo-cross-linkable coumarin segments and carboxylic groups was co-assembled with MWCNTs in aqueous solution while encapsulating the model enzyme namely glucose oxidase (GOx) simultaneously, generating necklace-like bio-nanocomposites (GOx@PAVE-CNTs) with GOx-loading polymeric nanoparticles as nanobeads and MWCNTs as conducting micron-string.	copolymer	15-24	hydroxyacid oxidase 1	Homo sapiens	278-281
31005767-2	2019	An amphiphilic copolymer PAVE containing photo-cross-linkable coumarin segments and carboxylic groups was co-assembled with MWCNTs in aqueous solution while encapsulating the model enzyme namely glucose oxidase (GOx) simultaneously, generating necklace-like bio-nanocomposites (GOx@PAVE-CNTs) with GOx-loading polymeric nanoparticles as nanobeads and MWCNTs as conducting micron-string.	copolymer	15-24	hydroxyacid oxidase 1	Homo sapiens	278-281
31117440-2	2019	Herein, we developed camptothecin (CPT)-conjugated prodrug (CPTP) micelles in which CPT was grafted to the poly(ethylene glycol)-poly(glutamic acid) block copolymer via a disulfide bond linker for a redox-triggered drug release.	copolymer	155-164	ceramide-1-phosphate transfer protein	Homo sapiens	60-64
31285776-0	2019	Development of a Biocompatible Copolymer Nanocomplex to Deliver VEGF siRNA for Triple Negative Breast Cancer.	copolymer	31-40	vascular endothelial growth factor A	Homo sapiens	64-68
31285776-5	2019	Methods: A novel biocompatible linear copolymer poly[bis(epsilon-Lys-PEI)Glut-PEG] (PLEGP) was developed to deliver VEGF siRNA for TNBC therapy.	copolymer	38-47	vascular endothelial growth factor A	Homo sapiens	116-120
31239670-9	2019	Conclusion: Our study shows that anti-HER2 conjugated OCP copolymer nanoparticles have the potential for the development of anticancer drug carriers.	copolymer	58-67	erb-b2 receptor tyrosine kinase 2	Homo sapiens	38-42
31247953-1	2019	This article describes a new block copolymer (EGm-b-APn, where m and n denote the degrees of polymerization) of poly(ethylene glycol) (PEG) and poly(1,4-(1-H-1,2,3-triazolylene)methylene) prepared by copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) polymerization of 3-azido-1-propyne (AP) in the presence of PEG carrying a propargyl moiety.	copolymer	35-44	alanyl aminopeptidase, membrane	Homo sapiens	52-55
31117745-7	2019	Although the PPO content significantly influences the overall amount of block copolymer adsorbed to the liposome, we found that polymer binding decreases with increasing cholesterol concentration in a universal fashion, with the fraction of bound polymer dropping 10-fold between 0 and 30 mol % cholesterol relative to the total content of POPC and cholesterol.	copolymer	78-87	protoporphyrinogen oxidase	Homo sapiens	13-16
31239670-8	2019	In the in vitro cytotoxicity, the anti-HER2 conjugated OCP copolymer nanoparticles showed the lowest IC50, which indicated an increase in the therapeutic efficacy of DOX to treat human breast cancer cells with the HER2 overexpression.	copolymer	59-68	erb-b2 receptor tyrosine kinase 2	Homo sapiens	39-43
31239670-8	2019	In the in vitro cytotoxicity, the anti-HER2 conjugated OCP copolymer nanoparticles showed the lowest IC50, which indicated an increase in the therapeutic efficacy of DOX to treat human breast cancer cells with the HER2 overexpression.	copolymer	59-68	erb-b2 receptor tyrosine kinase 2	Homo sapiens	214-218
30889721-1	2019	This study used atomic force microscopy (AFM) to elucidate the interaction of fibronectin (FN) on a conducting and partially biodegradable copolymer of poly(3,4-ethylenedioxythiophene) and poly(d,l-lactic acid) (PEDOT-co-PDLLA) in three different proportions (1:05, 1:25 and 1:50).	copolymer	139-148	fibronectin 1	Homo sapiens	78-89
30889721-1	2019	This study used atomic force microscopy (AFM) to elucidate the interaction of fibronectin (FN) on a conducting and partially biodegradable copolymer of poly(3,4-ethylenedioxythiophene) and poly(d,l-lactic acid) (PEDOT-co-PDLLA) in three different proportions (1:05, 1:25 and 1:50).	copolymer	139-148	fibronectin 1	Homo sapiens	91-93
30802764-1	2019	A highly stable nanocomposite of antioxidant activity was developed by immobilization of a superoxide dismutase-mimicking metal complex on copolymer-functionalized nanoclay.	copolymer	139-148	superoxide dismutase 1	Homo sapiens	91-111
31030507-3	2019	Meanwhile, motivated by articular cartilage-inspired superlubricity and mussel-inspired adhesion, a copolymer containing both dopamine methacrylamide and 2-methacryloyloxyethyl phosphorylcholine was synthesized (DMA-MPC) and spontaneously grafted onto the TNT surface, which was validated by characterization techniques such as scanning electron microscopy, water contact angle measurements, and X-ray photoelectron spectroscopy.	copolymer	100-109	chromosome 16 open reading frame 82	Homo sapiens	256-259
31052405-0	2019	Synthesis of Thermo-Responsive Block-Graft Copolymer Based on PCL and PEG Analogs, and Preparation of Hydrogel via Click Chemistry.	copolymer	43-52	PHD finger protein 1	Homo sapiens	62-65
30960540-7	2019	PEF-PET and PPF-PPT blends formed a copolymer at relatively low reactive blending times.	copolymer	36-45	tachykinin precursor 1	Homo sapiens	16-19
30697891-8	2019	A tadpole block copolymer was also synthesized starting from linear PSt as a macroinitiator.	copolymer	16-25	sulfotransferase family 1A member 1	Homo sapiens	68-71
30829473-0	2019	sp2-Hybridized Carbon-Containing Block Copolymer Templated Synthesis of Mesoporous Semiconducting Metal Oxides with Excellent Gas Sensing Property.	copolymer	39-48	Sp2 transcription factor	Homo sapiens	0-3
30829473-7	2019	We developed a variety of novel synthesis methods based on sp2-hybridized carbon-containing block copolymer, such as ligand-assisted assembly and resol-assisted assembly strategies, achieving a controllable and versatile synthesis of mesoporous semiconducting metal oxides with excellent gas sensing performance.	copolymer	98-107	Sp2 transcription factor	Homo sapiens	59-62
31459547-1	2019	An amphiphilic block copolymer (BCP) which contains both photoresponsive and thermoresponsive blocks was synthesized by the atom transfer radical polymerization approach.	copolymer	21-30	opsin 1, short wave sensitive	Homo sapiens	32-35
32254775-3	2019	Thus, we here report a conjugation compound consisting of a copolymer (PEG-b-PLL) and a peptide (Cys-Ile-Gln-Pro-Phe-Tyr-Pro, CP7).	copolymer	60-69	proline rich protein BstNI subfamily 2	Homo sapiens	126-129
33405834-4	2019	A hydrophobic derivative of indocyanine green, DCC, was synthesized and entrapped into a pH-sensitive photosensitizer-core copolymer, PDCZP, to form DCC@PDCZP.	copolymer	123-132	deleted in colorectal carcinoma	Mus musculus	47-50
30863051-1	2019	Background: An amphiphilic cationic copolymer cholesterol-g-poly(amine-co-ester), namely Chol-g-PMSC-PPDL synthesized in a chemoenzymatic route has been utilized as a carrier for p53 gene delivery to check its antitumor efficacy, using human prostate cancer cell line PC-3 (p53 null) as a model.	copolymer	36-45	tumor protein p53	Homo sapiens	179-182
30863051-1	2019	Background: An amphiphilic cationic copolymer cholesterol-g-poly(amine-co-ester), namely Chol-g-PMSC-PPDL synthesized in a chemoenzymatic route has been utilized as a carrier for p53 gene delivery to check its antitumor efficacy, using human prostate cancer cell line PC-3 (p53 null) as a model.	copolymer	36-45	tumor protein p53	Homo sapiens	274-277
33405834-4	2019	A hydrophobic derivative of indocyanine green, DCC, was synthesized and entrapped into a pH-sensitive photosensitizer-core copolymer, PDCZP, to form DCC@PDCZP.	copolymer	123-132	deleted in colorectal carcinoma	Mus musculus	149-152
30578808-6	2019	We demonstrate for the first time that an abiotic copolymer hydrogel nanoparticle (NP1) engineered to bind a key signaling protein, vascular endothelial growth factor (VEGF165), functions in vivo to suppress tumor growth by regulating angiogenesis.	copolymer	50-59	neuropilin 1	Mus musculus	83-86
30408674-12	2019	It was also revealed that higher toxicity of the PTX-NPs could be due to ability of copolymer to inhibit P-gp pumps and induce lysosomal membrane permeabilization (LMP).	copolymer	84-93	phosphoglycolate phosphatase	Homo sapiens	105-109
30640436-1	2019	Enhanced capabilities of stain removal and comfort control are simultaneously achieved by the light and thermo dual-responsive copolymer poly(triethylene glycol methyl ether methacrylate- co-ethylene glycol methacrylate- co-acrylamide azobenzene) (P(MEO3MA- co-EGMA- co-AAAB)) cross-linked on cotton fabrics.	copolymer	127-136	chloride voltage-gated channel 2	Homo sapiens	261-265
30640436-9	2019	In addition, the trans-AAAB units of the copolymer cause the cross-linked P(MEO3MA- co-EGMA- co-AAAB) layer to be more hydrophobic under ambient conditions.	copolymer	41-50	chloride voltage-gated channel 2	Homo sapiens	87-91
30142974-4	2019	Chitosan (CH) itself is a naturally derived copolymer of glucosamine and N-acetyl-glucosamine linked with a beta-1,4 bond.	copolymer	44-53	brain protein 1	Mus musculus	108-114
30534671-1	2018	The self-assembly of a high-chi silicon-containing side-chain liquid crystalline block copolymer (LC BCP) in bulk and in thin films is reported, and the structural transition process from the hexagonally packed cylinder (HEX) to the body-centered cubic structure (BCC) in thin films was examined by both reciprocal and real space experimental methods.	copolymer	87-96	hematopoietically expressed homeobox	Homo sapiens	221-224
30201563-3	2019	The graft copolymer gel was characterized by FTIR, TGA, SEM techniques.	copolymer	10-19	T-box transcription factor 1	Homo sapiens	51-54
30089817-4	2019	In this study, we developed a poly(ethylene glycol)-poly(lysine) block copolymer-ubenimex conjugate (PEG-b-PLys(Ube)) to increase the efficacy of reagents in APN/CD13+ cancer stem cells.	copolymer	71-80	alanyl aminopeptidase, membrane	Homo sapiens	158-161
30089817-4	2019	In this study, we developed a poly(ethylene glycol)-poly(lysine) block copolymer-ubenimex conjugate (PEG-b-PLys(Ube)) to increase the efficacy of reagents in APN/CD13+ cancer stem cells.	copolymer	71-80	alanyl aminopeptidase, membrane	Homo sapiens	162-166
30643235-3	2019	p(Man-TLR7) is a random copolymer composed of monomers that either target dendritic cells (DCs) via mannose-binding receptors or activate DCs via Toll-like receptor 7 (TLR7).	copolymer	24-33	toll like receptor 7	Homo sapiens	6-10
30643235-3	2019	p(Man-TLR7) is a random copolymer composed of monomers that either target dendritic cells (DCs) via mannose-binding receptors or activate DCs via Toll-like receptor 7 (TLR7).	copolymer	24-33	toll like receptor 7	Homo sapiens	146-166
30643235-3	2019	p(Man-TLR7) is a random copolymer composed of monomers that either target dendritic cells (DCs) via mannose-binding receptors or activate DCs via Toll-like receptor 7 (TLR7).	copolymer	24-33	toll like receptor 7	Homo sapiens	168-172
30886803-3	2019	Herein, a pH-sensitive and vitamin A (VA)-conjugated copolymer VA-polyethylene glycol-polyethyleneimine-poly(N-(N",N"-diisopropylaminoethyl)-co-benzylamino) aspartamide (T-PBP) is synthesized and assembled into superparamagnetic iron oxide (SPIO)-decorated cationic micelle for miRNA delivery.	copolymer	53-62	phosphatidylethanolamine binding protein 1	Rattus norvegicus	172-175
30089817-0	2019	Poly(ethylene glycol)-poly(lysine) block copolymer-ubenimex conjugate targets aminopeptidase N and exerts an antitumor effect in hepatocellular carcinoma stem cells.	copolymer	41-50	alanyl aminopeptidase, membrane	Homo sapiens	78-94
30168802-0	2018	Thermal stability of L10-FePt nanodots patterned by self-assembled block copolymer lithography.	copolymer	73-82	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	21-24
33418811-1	2018	Herein, a hydrophobized zwitterionic-based copolymer poly(sulfobetaine methacrylate-co-2-(dimethylamino)ethyl methacrylate-co-isobornyl acrylate) (P(SBMA-co-DMA-co-ISA), PSDI) containing a chiral structure has been successfully synthesized by free radical polymerization and subsequent sulfonation reactions.	copolymer	43-52	androgen receptor	Homo sapiens	149-153
30398853-2	2018	The photocurable copolymer, poly(glycidyl methacrylate- co-butyl acrylate- co-4-benzoylphenyl methacrylate) (GBB), was synthesized by single electron transfer-living radical polymerization (SET-LRP).	copolymer	17-26	LDL receptor related protein 1	Homo sapiens	194-197
30152680-1	2018	We report two new regioregular and regioirregular model copolymer acceptors based on selenophene and perylenetetracarboxylic diimide moieties, respectively, named RR-P(SePDI) and RI-P(SePDI), which were synthesized to study how regioregularity impacts the properties of resulting polymers.	copolymer	56-65	ribosome binding protein 1	Homo sapiens	163-174
30218295-1	2018	A novel copolymer poly(thiophene-2,5-diyl-2,5-di-n-octyloxycarbonyl-1,4-phenylene), denoted as P33, is introduced as potential material for photovoltaics, polymer light-emitting diodes, and/or organic transistors.	copolymer	8-17	inhibitor of growth family member 1	Homo sapiens	95-98
30277761-4	2018	Here, we demonstrate that covalent conjugation of a small molecule TLR7/8 agonist immunomodulatory to a micelle-forming amphiphilic block copolymer greatly alters the pharmacokinetic profile, resulting in highly efficient lymphatic delivery.	copolymer	138-147	toll like receptor 7	Homo sapiens	67-71
30379557-7	2018	The superior antifouling properties of the copolymer even after biofunctionalization were exploited to fabricate a new plasmonic biosensor for the analysis of fetuin-A in real clinical blood plasma samples.	copolymer	43-52	alpha 2-HS glycoprotein	Homo sapiens	159-167
30098571-3	2018	Herein, amphiphilic block copolymer radiosensitizers are prepared from clinically approved poly(ethylene glycol)-block-poly(l-glutamic acid) (PEG-b-PLG) and metronidazole (MN) to obtain MN-grafted PEG-b-PLG (PEG-b-P(LG-g-MN)) via condensation reaction, which can self-assemble into core-shell micelles as nanoparticle-formulated radiosensitizers in aqueous solution.	copolymer	26-35	plasminogen	Homo sapiens	148-151
30098571-3	2018	Herein, amphiphilic block copolymer radiosensitizers are prepared from clinically approved poly(ethylene glycol)-block-poly(l-glutamic acid) (PEG-b-PLG) and metronidazole (MN) to obtain MN-grafted PEG-b-PLG (PEG-b-P(LG-g-MN)) via condensation reaction, which can self-assemble into core-shell micelles as nanoparticle-formulated radiosensitizers in aqueous solution.	copolymer	26-35	plasminogen	Homo sapiens	203-206
30076930-2	2018	The prepared graft copolymer has been characterized in details using FTIR and 1H NMR spectral analyses, GPC, TGA, FESEM, TEM and DLS analyses.	copolymer	19-28	glycophorin C (Gerbich blood group)	Homo sapiens	104-107
30076930-2	2018	The prepared graft copolymer has been characterized in details using FTIR and 1H NMR spectral analyses, GPC, TGA, FESEM, TEM and DLS analyses.	copolymer	19-28	T-box transcription factor 1	Homo sapiens	109-112
30076930-3	2018	GPC analysis results indicate that the polymerization is controlled, while the LCST value of the copolymer suggests that the synthesized copolymer demonstrates sol-gel behaviour on applying temperature.	copolymer	137-146	glycophorin C (Gerbich blood group)	Homo sapiens	0-3
30165141-0	2018	E-selectin-targeted copolymer reduces atherosclerotic lesions, adverse cardiac remodeling, and dysfunction.	copolymer	20-29	selectin, endothelial cell	Mus musculus	0-10
30033252-4	2018	The basic copolymer was prepared by radical copolymerization of N-isopropyl acryl amide (NIPAAm) and N-vinylimidazole (VIm).	copolymer	10-19	vimentin	Homo sapiens	119-122
30479921-3	2018	Here, a supramolecular binary copolymer hydrogel termed as PNAGA-PCBAA by copolymerization of N-acryloyl glycinamide (NAGA) and carboxybetaine acrylamide (CBAA) is prepared.	copolymer	30-39	alpha-N-acetylgalactosaminidase	Homo sapiens	94-116
30168707-4	2018	Modifications using the copolymer layer on the cell culture surface have demonstrated synergistic activity by chitosan to support the formation of spheroids and by FGF-2 to enhance the proliferation of human adipose-derived stem cells (ADSCs) within the spheroids while increasing the spheroid size and cell numbers.	copolymer	24-33	fibroblast growth factor 2	Homo sapiens	164-169
30175915-1	2018	A new fabrication method for an ultrathin (500 nm thick) pressure-sensitive adhesive (PSA) was demonstrated by utilizing a series of in situ cross-linked viscoelastic copolymer films.	copolymer	167-176	aminopeptidase puromycin sensitive	Homo sapiens	86-89
30175915-5	2018	We controlled the cross-linking density of the copolymer films to exhibit a viscoelastic property so that they would readily adhere to various kinds of substrates with only 500 nm thick copolymer PSA.	copolymer	47-56	aminopeptidase puromycin sensitive	Homo sapiens	196-199
30175915-6	2018	The adhesion performance of the PSA was systematically optimized by tuning the copolymer composition as well as the cross-linking density, and consequently a high shear strength of more than 85.2 +- 5 N/cm2 was achieved despite the 500 nm thickness.	copolymer	79-88	aminopeptidase puromycin sensitive	Homo sapiens	32-35
30479921-3	2018	Here, a supramolecular binary copolymer hydrogel termed as PNAGA-PCBAA by copolymerization of N-acryloyl glycinamide (NAGA) and carboxybetaine acrylamide (CBAA) is prepared.	copolymer	30-39	alpha-N-acetylgalactosaminidase	Homo sapiens	60-64
29350902-1	2018	In this report, a new star-like copolymer beta-CD- g-(PNIPAAm- b-POEGA) x, consisting of a beta-CD core, grafted with temperature-responsive poly( N-isopropylacrylamide) (PNIPAAm) and biocompatible poly(oligo(ethylene glycol) acrylate) (POEGA) in a block copolymer of the arms, was used to deliver chemotherapeutics to drug resistant cancer cells and tumors.	copolymer	255-264	beta-carotene oxygenase 1	Mus musculus	42-49
30052457-3	2018	This dually gated polymersome is self-assembled from a block copolymer, poly(ethylene oxide)- block-poly[ N-isopropylacrylamide- stat-7-(2-methacryloyloxyethoxy)-4-methylcoumarin- stat-2-(diethylamino)ethyl methacrylate] [PEO- b-P(NIPAM- stat-CMA- stat-DEA)].	copolymer	61-70	twinkle mtDNA helicase	Homo sapiens	222-225
30225076-4	2018	In this work, a simple and convenient method to prepare nanotubes using conjugated copolymer of perylene diimide and dithienothiophene (P(PDI-DTT)) was demonstrated.	copolymer	83-92	peptidyl arginine deiminase 1	Homo sapiens	138-141
29635085-6	2018	FINDINGS: The GPC analysis shows the low polydispersity of the developed copolymer that signifies the controlled nature of polymerization.	copolymer	73-82	glycophorin C (Gerbich blood group)	Homo sapiens	14-17
30122920-0	2018	Synthesis of a hemin-containing copolymer as a novel immunostimulator that induces IFN-gamma production.	copolymer	32-41	interferon gamma	Homo sapiens	83-92
29733637-9	2018	PEG47- b-PAMPS108 anticoagulant activity can be efficiently reversed with a copolymer of PEG and poly((3-(methacryloylamino)propyl)trimethylammonium chloride) (PMAPTAC) (PEG41- b-PMAPTAC53, HBC), which may be attributed to the formation of polyelectrolyte complexes with PEG shells without anticoagulant properties.	copolymer	76-85	keratin 88, pseudogene	Homo sapiens	190-193
29674293-6	2018	In contrast, adsorption of positively charged Ly on copolymer micelle is very low.	copolymer	52-61	lysozyme	Homo sapiens	46-48
29620538-4	2018	An imidazole-bearing amphiphilic copolymer was employed as the micelle building block to encapsulate triphenylphosphonium-pyropheophorbide a (TPP-PPa) conjugate or PPa.	copolymer	33-42	preproenkephalin	Mus musculus	146-149
29620538-4	2018	An imidazole-bearing amphiphilic copolymer was employed as the micelle building block to encapsulate triphenylphosphonium-pyropheophorbide a (TPP-PPa) conjugate or PPa.	copolymer	33-42	preproenkephalin	Mus musculus	164-167
29350902-1	2018	In this report, a new star-like copolymer beta-CD- g-(PNIPAAm- b-POEGA) x, consisting of a beta-CD core, grafted with temperature-responsive poly( N-isopropylacrylamide) (PNIPAAm) and biocompatible poly(oligo(ethylene glycol) acrylate) (POEGA) in a block copolymer of the arms, was used to deliver chemotherapeutics to drug resistant cancer cells and tumors.	copolymer	32-41	beta-carotene oxygenase 1	Mus musculus	42-49
29350902-1	2018	In this report, a new star-like copolymer beta-CD- g-(PNIPAAm- b-POEGA) x, consisting of a beta-CD core, grafted with temperature-responsive poly( N-isopropylacrylamide) (PNIPAAm) and biocompatible poly(oligo(ethylene glycol) acrylate) (POEGA) in a block copolymer of the arms, was used to deliver chemotherapeutics to drug resistant cancer cells and tumors.	copolymer	32-41	beta-carotene oxygenase 1	Mus musculus	91-98
30084632-0	2018	Polymerization Induced Self-Assembly of a Site-Specific Interferon alpha-Block Copolymer Conjugate into Micelles with Remarkably Enhanced Pharmacology.	copolymer	79-88	interferon alpha	Mus musculus	56-72
30084632-3	2018	An amphiphilic block copolymer (POEGMA-PHPMA) was directly grown from the C-terminus of an important therapeutic protein interferon-alpha (IFN) to in situ form IFN-POEGMA-PHPMA conjugate micelles.	copolymer	21-30	interferon alpha	Mus musculus	121-137
30024587-4	2018	An arylboronic ester (BE)-modified amphiphilic copolymer (mPEG-PBAM) was designed to form micelles and encapsulate doxorubicin (Dox) and hematoporphyrin (Hp).	copolymer	47-56	solute carrier family 10 member 2	Homo sapiens	63-67
29952543-2	2018	When the PS- b-PMMA film dewets on a 2 nm-thick RCP layer, the ordering of the hexagonally packed PMMA cylinders in the dewetted structures extends over distances far exceeding the correlation length obtained in continuous block copolymer (BCP) films.	copolymer	229-238	CGRP receptor component	Homo sapiens	48-51
29618203-3	2018	The MPEG-PLH-VES copolymer exerts no obvious effect on the P-gp expression level of MCF-7/ADR but exhibited a significant influence on the loss of mitochondrial membrane potential, the reduction of intracellular ATP level, and the inhibition of P-gp ATPase activity of MCF-7/ADR cells.	copolymer	17-26	phosphoglycolate phosphatase	Homo sapiens	245-249
30960648-5	2018	The resultant copolymer film was adopted as the electrode material to immobilize glucose oxidase (GOx) for construction of an enzyme biosensor.	copolymer	14-23	hydroxyacid oxidase 1	Homo sapiens	81-96
30960648-5	2018	The resultant copolymer film was adopted as the electrode material to immobilize glucose oxidase (GOx) for construction of an enzyme biosensor.	copolymer	14-23	hydroxyacid oxidase 1	Homo sapiens	98-101
29845983-3	2018	Here, ZnO nanoparticles were used as the electron-transporting material (ETM) and methylammonium lead iodide (MAPbI3) perovskite was used as the light-absorbing material to form an FTO/ZnO/MAPbI3/copolymer/Ag device, of which the power conversion efficiency (PCE) was found to be dependent on the copolymer composition and reached a maximum (~10%) at a P3TAA content of 43 mol% in the copolymer (P3).	copolymer	196-205	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	181-184
29845983-3	2018	Here, ZnO nanoparticles were used as the electron-transporting material (ETM) and methylammonium lead iodide (MAPbI3) perovskite was used as the light-absorbing material to form an FTO/ZnO/MAPbI3/copolymer/Ag device, of which the power conversion efficiency (PCE) was found to be dependent on the copolymer composition and reached a maximum (~10%) at a P3TAA content of 43 mol% in the copolymer (P3).	copolymer	297-306	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	181-184
29845983-3	2018	Here, ZnO nanoparticles were used as the electron-transporting material (ETM) and methylammonium lead iodide (MAPbI3) perovskite was used as the light-absorbing material to form an FTO/ZnO/MAPbI3/copolymer/Ag device, of which the power conversion efficiency (PCE) was found to be dependent on the copolymer composition and reached a maximum (~10%) at a P3TAA content of 43 mol% in the copolymer (P3).	copolymer	297-306	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	181-184
29350902-4	2018	More interestingly, this supramolecular host-guest nanocomplex promoted the enhanced cellular uptake of chemotherapeutics in MDR-1 up-regulated drug resistant cancer cells and exhibited high therapeutic efficacy for suppressing drug resistant tumor growth in an in vivo mouse model, due to the increased stability, improvement in aqueous solubility, enhanced cellular uptake, and partial membrane pump impairment by taking the advantage of PEGylation and supramolecular complex between this star-like copolymer and chemotherapeutics.	copolymer	501-510	malic enzyme complex, mitochondrial	Mus musculus	125-130
29744937-2	2018	In this work, the emissive organometallic complex, [CuBr(PPh3 )2 (4-methylpyridine)], is successfully, mechanically ground into a random copolymer built on 4-(diphenylphosphino)styrene (DPVP) and n-butyl acrylate (BA) monomers.	copolymer	137-146	protein phosphatase 4 catalytic subunit	Homo sapiens	57-61
29747513-4	2018	The copolymer interacts with miR-34a at low N/P ratios (~2/1) to form nanoplexes of size ~108 nm and a zeta potential ~ +39 mV.	copolymer	4-13	microRNA 34a	Homo sapiens	29-36
29683273-4	2018	To prevent infection, biocompatible nanocarriers of polypeptide-based block copolymer micelles are deposited onto the surfaces of PCL/Coll nanofibers using tannic acid as a binding partner.	copolymer	76-85	PHD finger protein 1	Homo sapiens	130-133
29196042-5	2018	Along with the cross-linked polyion complex of SOD1 with polycation poly(ethylene glycol) (PEG)-polylysine (single-coat (SC) nanozyme), we introduce for the first time the chemically cross-linked multilayer polyion complex in which SOD1 is first incorporated into a polyion complex with polycation, then coated by anionic block copolymer, PEG-polyglutamic acid (double-coat (DC) nanozyme).	copolymer	328-337	superoxide dismutase 1	Rattus norvegicus	47-51
29848991-4	2018	The pH-sensitive copolymer methoxy poly(ethylene glycol)-block-poly(methacrylic acid)-cholesterol (mPEG-b-P(MAAc)-chol) and crosslinking reagent poly(ethylene glycol) with end-capped with lysine (PEG-Lys2) were synthesized and characterized.	copolymer	17-26	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	Homo sapiens	200-204
29883571-0	2018	Magnetic Nanoparticles Associated PEG/PLGA Block Copolymer Targeted with Anti-Transferrin Receptor Antibodies for Alzheimer"s Disease.	copolymer	49-58	transferrin	Homo sapiens	78-89
29565307-5	2018	Tcp was approximately consistent with the critical temperature of intermolecular copolymer association (Tass) from DLS.	copolymer	81-90	serine peptidase inhibitor Kazal type 1	Homo sapiens	0-3
29253332-3	2018	The hydrated copolymer preserved the thermoresponsive properties from the ELP block and formed hydrogels with different transition temperatures depending on salt concentration.	copolymer	13-22	nuclear receptor subfamily 5 group A member 1	Homo sapiens	74-77
29423262-7	2018	Thus, PLG-b-PMPC copolymer might be a promising carrier for CDDP incorporating in cancer therapy.	copolymer	17-26	plasminogen	Mus musculus	6-9
30966638-2	2018	The anodic copolymer with DiCP:cyclopentadithiophene ketone (CPDTK) = 1:1 feed molar ratio showed high transmittance change (DeltaT%) and colouration efficiency (eta), which were measured as 39.5% and 184.1 cm2 C-1 at 1037 nm, respectively.	copolymer	11-20	endothelin receptor type A	Homo sapiens	162-165
29624869-3	2018	The simple donor-acceptor (D-A) type copolymer of bithiophene (BT) and BAz exhibited intense photoluminescence (PL) in the NIR region both in the dilute solution (lambdaPL =751 nm, PhiPL =0.25) and in the film (lambdaPL =821 nm, PhiPL =0.038).	copolymer	37-46	par-3 family cell polarity regulator	Homo sapiens	71-74
29595951-4	2018	Second-step delivery of multivalent polymeric effector (linear copolymer conjugated with multiple copies of complementary oligonucleotide 2) simultaneously hybridizes multiple CD20-bound engagers and strengthens CD20 ligation.	copolymer	63-72	keratin 20	Homo sapiens	176-180
29595951-4	2018	Second-step delivery of multivalent polymeric effector (linear copolymer conjugated with multiple copies of complementary oligonucleotide 2) simultaneously hybridizes multiple CD20-bound engagers and strengthens CD20 ligation.	copolymer	63-72	keratin 20	Homo sapiens	212-216
29331439-1	2018	Recent work demonstrated remarkable solubilization effects of methacrylate-copolymer Eudragit EPO (EPO) not only with acidic drugs but interestingly also with poorly soluble basic compounds.	copolymer	75-84	erythropoietin	Rattus norvegicus	94-97
29331439-1	2018	Recent work demonstrated remarkable solubilization effects of methacrylate-copolymer Eudragit EPO (EPO) not only with acidic drugs but interestingly also with poorly soluble basic compounds.	copolymer	75-84	erythropoietin	Rattus norvegicus	99-102
29468880-3	2018	The influences of the monomer concentration, the copolymer nanosphere additive content, the load, and the frequency of the friction conditions on their tribological properties were studied in detail, and a probable antiwear mechanism of the soft/hard-coupled copolymer nanospheres under water lubrication was also proposed.	copolymer	49-58	POC1 centriolar protein A	Homo sapiens	241-245
29534078-10	2018	Finally, a copolymer resin (Elvax) was trialled for the slow-release delivery of VCP to the retina.	copolymer	11-20	valosin containing protein	Homo sapiens	81-84
29218755-0	2018	Reducing Trap-Assisted Recombination in Small Organic Molecule-Based Photovoltaics by the Addition of a Conjugated Block Copolymer.	copolymer	121-130	TRAP	Homo sapiens	9-13
29386057-0	2018	Delivery of VEGFA in bone marrow stromal cells seeded in copolymer scaffold enhances angiogenesis, but is inadequate for osteogenesis as compared with the dual delivery of VEGFA and BMP2 in a subcutaneous mouse model.	copolymer	57-66	vascular endothelial growth factor A	Mus musculus	12-17
29134801-4	2017	The most protein-resistant copolymer layers, eliminating fibrinogen and lysozyme adsorption within detectible limits of 0.01 mg/m2, had metrics (the amount of pMPC at the surface and the reduced tether footprint) consistent with the formation of an interfacial polymer brush.	copolymer	27-36	fibrinogen beta chain	Homo sapiens	57-67
29030300-1	2017	A pH-sensitive copolymer PAsp(DIP)-b-PAsp(MEA) (PDPM) was synthesized and self-assembled to micelle loading chemotherapeutic drug doxorubicin (DOX) and introducing a gold nanocage structure for photothermo-chemotherapy and photoacoustic imaging.	copolymer	15-24	tripartite motif containing 44	Homo sapiens	25-36
29416334-0	2018	Copolymer micelles function as pH-responsive nanocarriers to enhance the cytotoxicity of a HER2 aptamer in HER2-positive breast cancer cells.	copolymer	0-9	erb-b2 receptor tyrosine kinase 2	Homo sapiens	91-95
29416334-0	2018	Copolymer micelles function as pH-responsive nanocarriers to enhance the cytotoxicity of a HER2 aptamer in HER2-positive breast cancer cells.	copolymer	0-9	erb-b2 receptor tyrosine kinase 2	Homo sapiens	107-111
30463066-2	2018	METHODS: We prepared iNOS-MNPs using an anionic block copolymer template-mediated calcium carbonate (CaCO3) mineralization process in the presence of iNOS.	copolymer	54-63	nitric oxide synthase 2, inducible	Mus musculus	21-25
28737462-3	2017	The conjugated copolymer was characterized in vitro by 1H-NMR, FTIR, DSC and GPC techniques.	copolymer	15-24	glycophorin C (Gerbich blood group)	Homo sapiens	77-80
28985085-5	2017	Relatively small micelles of pretty high nematic order parameter, S2   0.5-0.8, are the features of the Y-shaped and rod-coil copolymer micelles.	copolymer	126-135	coilin	Homo sapiens	121-125
28985085-7	2017	The aggregation number of the rod-coil diblock copolymer micelles increases and that of the Y-shaped copolymer micelles decreases at the solvent quality worsening.	copolymer	47-56	coilin	Homo sapiens	34-38
28472686-3	2017	The synthesized grafted samples were subjected to various analytical techniques such as FTIR, XRD, TGA and DSC methods The proof of formation of graft copolymer was ascertained from the results of FTIR analysis and XRD studies.	copolymer	151-160	T-box transcription factor 1	Homo sapiens	99-102
28472686-4	2017	The TGA and DSC results conclude the highly thermally stable behavior of the prepared graft copolymer sample.	copolymer	92-101	T-box transcription factor 1	Homo sapiens	4-7
28732712-5	2017	The most promising copolymer was chosen to formulate the osteoinductive protein bone morphogenetic protein-2 (125I-BMP-2), and the ability of its gels to sustain the release both in vitro and in vivo was monitored in situ using a gamma counter.	copolymer	19-28	bone morphogenetic protein 2	Homo sapiens	80-108
28732712-5	2017	The most promising copolymer was chosen to formulate the osteoinductive protein bone morphogenetic protein-2 (125I-BMP-2), and the ability of its gels to sustain the release both in vitro and in vivo was monitored in situ using a gamma counter.	copolymer	19-28	bone morphogenetic protein 2	Homo sapiens	115-120
28714224-0	2017	Codelivery for Paclitaxel and Bcl-2 Conversion Gene by PHB-PDMAEMA Amphiphilic Cationic Copolymer for Effective Drug Resistant Cancer Therapy.	copolymer	88-97	BCL2 apoptosis regulator	Homo sapiens	30-35
30023528-3	2017	In this work, poly(NIPA)-b-poly(HMNPPA)-b-poly(PEGMA-stat-BA) was synthesized using reversible addition fragmentation chain transfer polymerization and Chlorambucil (Cbl), an anticancer drug, was conjugated to the copolymer via 3-(3-(hydroxymethyl)-4-nitrophenoxy)propyl acrylate (HMNPPA) units to prepare the prodrug.	copolymer	214-223	zinc finger C3HC-type containing 1	Homo sapiens	19-23
28821028-6	2017	Furthermore, the PEI/WSC copolymer with a dendrimer RGD peptide (four-branched RGD moiety) as a targeting moiety suppressed the growth of a solid tumor mass in vivo mouse xenograft model generated with PC3 prostate tumor cells by silencing BCL2 mRNA.	copolymer	25-34	chromobox 8	Mus musculus	202-205
28821028-6	2017	Furthermore, the PEI/WSC copolymer with a dendrimer RGD peptide (four-branched RGD moiety) as a targeting moiety suppressed the growth of a solid tumor mass in vivo mouse xenograft model generated with PC3 prostate tumor cells by silencing BCL2 mRNA.	copolymer	25-34	B cell leukemia/lymphoma 2	Mus musculus	240-244
28576046-6	2017	The prepared copolymer can form a polymersome and effectively condense with VEGF without affecting its size and surface charges.	copolymer	13-22	vascular endothelial growth factor A	Homo sapiens	76-80
28778054-4	2017	A triblock amphiphilic copolymer, methoxy-poly(ethylene glycol) 2000-poly(2-(N,N-diethylamino)ethyl methacrylate)-polycaprolactone (mPEG-PDEA-PCL, PDC), was used to load paclitaxel (PTX), a hydrophobic anticancer agent, using an injection method.	copolymer	23-32	phosphodiesterase 6A	Homo sapiens	137-141
28526344-1	2017	A specially-designed graft copolymer of acrylic acid onto in-situ formed cellulose-fulvate hybrid showed privileged tendency for uptake of Pb(II) during competitive removal from a mixture containing Cd(II) and Ni(II) within 5min at pH 5.	copolymer	27-36	submaxillary gland androgen regulated protein 3B	Homo sapiens	139-145
28526344-4	2017	Thus, the designed graft copolymer structure exhibited superior efficiency that reached ~95% for sole removal of Pb(II).	copolymer	25-34	submaxillary gland androgen regulated protein 3B	Homo sapiens	113-119
28526344-8	2017	The Langmuir and Freundlich models showed convenience with the adsorption isotherm of Pb(II) onto the developed graft copolymer.	copolymer	118-127	submaxillary gland androgen regulated protein 3B	Homo sapiens	86-92
28658642-1	2017	The current study utilizes folic acid conjugated poly(styrene-co-maleic anhydride) block copolymer (FA-SMA) to enhance the solubility of a hydrophobic but very potent synthetic curcumin-difluorinated (CDF) analog and its targeted delivery to folate receptor-alpha overexpressing cancers.	copolymer	89-98	survival of motor neuron 1, telomeric	Homo sapiens	103-106
28658642-1	2017	The current study utilizes folic acid conjugated poly(styrene-co-maleic anhydride) block copolymer (FA-SMA) to enhance the solubility of a hydrophobic but very potent synthetic curcumin-difluorinated (CDF) analog and its targeted delivery to folate receptor-alpha overexpressing cancers.	copolymer	89-98	folate receptor alpha	Homo sapiens	242-263
28535990-1	2017	Pluronics P94 are block-copolymer showing prolonged circulation time and tumor-cell internalization in vitro, suggesting a potential for tumor accumulation and as a drug carrier.	copolymer	24-33	calpain 3	Mus musculus	10-13
29158816-5	2017	Hence, zwitterionic biodegradable copolymer poly(lactide)-polycarboxybetaine (PLA-PCB, PP), companied with PS, was used to provide a good colloidal stability and long blood circulation for the nanocubes.	copolymer	34-43	pyruvate carboxylase	Rattus norvegicus	82-85
28576046-7	2017	The Gaussian curve fit (GCF) of amide I band were revealed that VEGF efficiently interact through the alpha-helix of the amphiphilic graft copolymer rather than beta-sheet dominated poly(l-lysine).	copolymer	139-148	vascular endothelial growth factor A	Homo sapiens	64-68
32264452-2	2017	Herein, we designed a pH-responsive copolymer (PEG-ELP[VH4-70]) that entraps DOX into a hydrophobic core and self-assembles into smart DOX-loaded nanoparticles.	copolymer	36-45	diazepam binding inhibitor-like 5	Mus musculus	51-54
28735537-1	2017	A unique combination of molecular dynamics (MD) simulation and detailed size exclusion chromatography-multiangle light scattering (SEC-MALS) analysis is used to provide important a priori insights into the solution self-assembly of a well-defined and symmetric tetrablock copolymer with two acrylic acid (AA) outer blocks, two polystyrene (PS) inner blocks, and a trithiocarbonate (TTC) central group, prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization.	copolymer	272-281	natural cytotoxicity triggering receptor 3	Homo sapiens	135-139
28861765-3	2017	Human epidermal growth factor receptor 2 (HER2) targeting peptide LTVSPWY (PEP) and triphenylphosphonium lipophilic cation (TPP) were conjugated to a previously optimized RAFT block copolymer that formed self-assembled NP of appropriate size for this application and low polydispersity by self-organized precipitation method.	copolymer	182-191	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-40
28861765-3	2017	Human epidermal growth factor receptor 2 (HER2) targeting peptide LTVSPWY (PEP) and triphenylphosphonium lipophilic cation (TPP) were conjugated to a previously optimized RAFT block copolymer that formed self-assembled NP of appropriate size for this application and low polydispersity by self-organized precipitation method.	copolymer	182-191	erb-b2 receptor tyrosine kinase 2	Homo sapiens	42-46
28590596-0	2017	Alternating Copolymer of Double Four Ring Silicate and Dimethyl Silicone Monomer-PSS-1.	copolymer	12-21	corneodesmosin	Homo sapiens	81-86
28590596-1	2017	A new copolymer consisting of double four ring (D4R) silicate units linked by dimethylsilicone monomer referred to as polyoligosiloxysilicone number one (PSS-1) was synthesized.	copolymer	6-15	corneodesmosin	Homo sapiens	154-159
28093296-2	2017	Here, we report on the development of a new CD44-targeted copolymer carrying multiple copies of the A5G27 peptide, known for its ability to bind specifically to CD44v3 and CD44v6 on cancer cells and inhibit tumor cell migration, invasion, and angiogenesis.	copolymer	58-67	CD44 antigen	Mus musculus	44-48
30970990-3	2017	The mechanisms of negative ECE and the enhanced negative ECE in the nanocomposites consisting of poly(VDF-co-TrFE) and BT nanowires are explained by the Kauzmann theory on glassy polar states and the interaction between BT nanofillers and the copolymer matrix.	copolymer	243-252	endothelin converting enzyme 1	Homo sapiens	57-60
28609612-3	2017	Here, we harness the low-complexity (LC) sequence domain of fused in sarcoma (FUS) protein, an essential cellular nuclear protein with slow kinetics of amyloid fiber assembly, to construct random copolymer-like, multiblock, and self-sorted supramolecular fibrous networks with distinct structural features and fluorescent functionalities.	copolymer	196-205	FUS RNA binding protein	Homo sapiens	60-76
28609612-3	2017	Here, we harness the low-complexity (LC) sequence domain of fused in sarcoma (FUS) protein, an essential cellular nuclear protein with slow kinetics of amyloid fiber assembly, to construct random copolymer-like, multiblock, and self-sorted supramolecular fibrous networks with distinct structural features and fluorescent functionalities.	copolymer	196-205	FUS RNA binding protein	Homo sapiens	78-81
28570761-2	2017	A block copolymer with attached fructose, which interacts with GLUT5 receptor, was used and conjugated with a low and a high amount of platinum drugs.	copolymer	8-17	solute carrier family 2 member 5	Homo sapiens	63-68
28793338-4	2017	Herein, a novel chemically synthesized peptide (E5) that has an ability to target CXCR4/CXCL12 axis was loaded in micelle glycol-phosphatidylethanolamine (PEG-PE) block copolymer to form micelle-encapsulated E5 (M-E5).	copolymer	169-178	C-X-C motif chemokine receptor 4	Homo sapiens	82-87
28793338-4	2017	Herein, a novel chemically synthesized peptide (E5) that has an ability to target CXCR4/CXCL12 axis was loaded in micelle glycol-phosphatidylethanolamine (PEG-PE) block copolymer to form micelle-encapsulated E5 (M-E5).	copolymer	169-178	C-X-C motif chemokine ligand 12	Homo sapiens	88-94
32264215-6	2017	The grafting of beta-cyclodextrin (beta-CD) onto chitosan chains demonstrated remarkable cellular uptake (~5-fold) compared to pure chitosan at N/P = 6, attributed to a strong interaction and temporary disruption of the lipid bilayer in the cell membrane by the synthesized copolymer.	copolymer	274-283	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	35-42
28640588-2	2017	Here we show that a complex of salmon calcitonin and oxidized calcium alginate (sCT-OCA) was prepared and loaded into a thermosensitive copolymer hydrogel for long-term antiosteopenia treatment.	copolymer	136-145	calcitonin-related polypeptide alpha	Rattus norvegicus	38-48
28640588-2	2017	Here we show that a complex of salmon calcitonin and oxidized calcium alginate (sCT-OCA) was prepared and loaded into a thermosensitive copolymer hydrogel for long-term antiosteopenia treatment.	copolymer	136-145	secretin	Rattus norvegicus	80-83
28505457-4	2017	The objective of this study was to formulate copolymer-based NPs containing model fluorescent-tagged bovine serum albumin (BSA) with GPA-specific targeting ligands such as ERY1 (ENPs), single-chain variable antibody (scFv TER-119, SNPs), and low-molecular-weight protamine-based CPP (LNPs) and to determine their biocompatibility using a variety of complementary high-throughput in vitro assays.	copolymer	45-54	albumin	Homo sapiens	108-121
28482577-0	2017	Targeted delivery of Bcl-2 conversion gene by MPEG-PCL-PEI-FA cationic copolymer to combat therapeutic resistant cancer.	copolymer	71-80	BCL2 apoptosis regulator	Homo sapiens	21-26
28586102-6	2017	After being encapsulated with biodegradable copolymer pluronic F-127-folic acid (F-127-FA), RET-BDP molecules can form uniform and small organic nanoparticles that are water soluble and tumor targetable.	copolymer	44-53	AT-rich interaction domain 3B	Homo sapiens	96-99
28482519-0	2017	Synthesis of star-like hybrid POSS-(PDMAEMA-b-PDLA)8 copolymer and its stereocomplex properties with PLLA.	copolymer	53-62	PDON2	Homo sapiens	46-50
27008163-0	2017	Binary-copolymer system base on low-density lipoprotein-coupled N-succinyl chitosan lipoic acid micelles for co-delivery MDR1 siRNA and paclitaxel, enhances antitumor effects via reducing drug.	copolymer	7-16	ATP binding cassette subfamily B member 1	Homo sapiens	121-125
28690967-3	2017	Here, we report the synthesis of [Fe(Leq)(Lax)]n coordination polymer (CP) nanoparticles using self-assembled polystyrene-block-poly(4-vinylpyridine) (PS-b-P4VP) block copolymer (BCP) micelles as template.	copolymer	168-177	lymphocyte transmembrane adaptor 1	Homo sapiens	42-45
28482519-3	2017	In the next step, the synthesized hybrid copolymer POSS-(PDMAEMA-b-PDLA)8 was blended with PLLA in solution to form nanocomposites to further modify the thermo-mechanical and degradation properties of PLLA.	copolymer	41-50	PDON2	Homo sapiens	67-71
28482520-4	2017	The characterization of copolymer p-DMA-b-SAM was done by 1H NMR, ATR-FTIR and GPC.	copolymer	24-33	glycophorin C (Gerbich blood group)	Homo sapiens	66-82
28119221-6	2017	As the mole concentration of copolymer is increased from 10% to 50%, the microstructures formed by PCL-PDEA-PSBMA and DOX remains spherical micelles whereas PCL-PDEA-PEGMA undergoes structural transition from spherical to cylindrical and finally to lamellar micelles.	copolymer	29-38	phosphodiesterase 6A	Homo sapiens	103-107
28970881-1	2017	In this study, for the first time, we report a solution-processed amino-functionalized copolymer semiconductor (PFN-2TNDI) with a conjugated backbone composed of fluorine, naphthalene diimide, and thiophene spacers as the electron transporting layer (ETL) in n-i-p planar structured perovskite solar cells.	copolymer	87-96	profilin 2	Homo sapiens	112-117
28263073-5	2017	In this study, we further our investigation into this area by exploring the impact of copolymer block size on the biological performance of Cat S-degradable HPMA copolymers.	copolymer	86-95	cathepsin S	Homo sapiens	140-145
28638077-3	2017	Introduction of PPI block in the block copolymer architecture enabled PTh- b -PPI film to exhibit solid-to-liquid crystal phase transition by exposure to chloroform vapour, accompanied with colour change (purple-to-yellow), which is the first report on a new phenomenon of "vapour-induced liquid crystallinity".	copolymer	39-48	parathyroid hormone	Homo sapiens	70-73
28332741-4	2017	The PMMA side chains served to securely anchor the graft copolymers to the membrane substrate, and the blended membrane prepared from binary graft copolymer was more stable and exhibited more robust stimuli-responsive behavior than that prepared from mono-graft copolymer PSf-g-P(NIPAAm-co-AA).	copolymer	147-156	insulin like growth factor binding protein 7	Homo sapiens	272-275
28119221-6	2017	As the mole concentration of copolymer is increased from 10% to 50%, the microstructures formed by PCL-PDEA-PSBMA and DOX remains spherical micelles whereas PCL-PDEA-PEGMA undergoes structural transition from spherical to cylindrical and finally to lamellar micelles.	copolymer	29-38	phosphodiesterase 6A	Homo sapiens	161-165
28088077-0	2017	RhoA knockdown by cationic amphiphilic copolymer/siRhoA polyplexes enhances axonal regeneration in rat spinal cord injury model.	copolymer	39-48	ras homolog family member A	Rattus norvegicus	0-4
28287223-8	2017	Human growth hormone (hGH)-loaded polypeptide-based biodegradable copolymer sols readily formed a viscoelastic gel that inhibited an initial burst and prolonged the hGH release for one week.	copolymer	66-75	growth hormone 1	Homo sapiens	6-20
27807937-0	2017	Thermo-Responsive Complexes of c-Myc Antisense Oligonucleotide with Block Copolymer of Poly(OEGMA) and Quaternized Poly(4-Vinylpyridine).	copolymer	74-83	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	31-36
27807937-4	2017	Polyelectrolyte complexes of this copolymer with the antisense oligonucleotide of c-Myc oncogene are also thermo-responsive but, have lower LCST (lower critical solution temperature) values compared to individual copolymer.	copolymer	34-43	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	82-87
27807937-4	2017	Polyelectrolyte complexes of this copolymer with the antisense oligonucleotide of c-Myc oncogene are also thermo-responsive but, have lower LCST (lower critical solution temperature) values compared to individual copolymer.	copolymer	213-222	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	82-87
28169391-3	2017	Herein, we propose a zwitterionic copolymer, namely poly(glycidyl methacrylate-co-sulfobetaine methacrylate) (poly(GMA-co-SBMA)), for the surface modification of SERS substrates, which were fabricated and characterized spectroscopically.	copolymer	34-43	androgen receptor	Homo sapiens	122-126
27419808-6	2017	Along with time-dependent and dose-dependent behavior, lubrication and binding of the lubricin-mimetics also depended on copolymer structural parameters including pAA backbone length, PEG side chain length, and PEG:AA brush density.	copolymer	121-130	proteoglycan 4	Homo sapiens	86-94
28208297-2	2017	The copolymer receptor is optimized in three aspects: (1) mole ratio of mPD:ASA monomers, (2) size of copolymer nanoparticles, and (3) surface density of the copolymer.	copolymer	4-13	mevalonate (diphospho) decarboxylase	Mus musculus	72-75
28208297-3	2017	It is shown that the 95:5 (mPD:ASA mole ratio) copolymer with size less than 100 nm exhibits the best Pb(II)-sensing performance, and the 200 times diluted standard copolymer solution contributes to the most effective functionalization protocol.	copolymer	47-56	mevalonate (diphospho) decarboxylase	Mus musculus	27-30
27615730-0	2017	The Pentablock Amphiphilic Copolymer T1107 Prevents Aggregation of Denatured and Reduced Lysozyme.	copolymer	27-36	lysozyme	Homo sapiens	89-97
28079950-2	2017	These results provide strong evidence that the -CHF2 and -CH2 F chain ends in E/VF copolymer generated by (phosphinoarenesulfonate)PdR catalysts form by beta-F elimination of Pd(beta-F-alkyl) species, VF or E insertion of the resulting (PO)PdF species, and subsequent chain growth.	copolymer	83-92	hes related family bHLH transcription factor with YRPW motif 1	Homo sapiens	48-52
28151040-4	2017	In this work, we evaluated the potential impact of NPs prepared from a grafted copolymer of polylactic acid and PEG on P-gp function by studying in vitro permeability of Famotidine across Caco-2 cells.	copolymer	79-88	ATP binding cassette subfamily B member 1	Homo sapiens	119-123
28044375-2	2017	The linear alpha,omega-telechelic multiblock copolymer is prepared via SET-LRP by sequential addition of different monomers.	copolymer	45-54	LDL receptor related protein 1	Homo sapiens	75-78
27648819-0	2017	Controlled Release of Hepatocyte Growth Factor from MPEG-b-(PCL-ran-PLLA) Diblock Copolymer for Improved Vocal Fold Regeneration.	copolymer	82-91	hepatocyte growth factor	Oryctolagus cuniculus	22-46
32263548-0	2017	Preparation, characterization, biotoxicity, and biodistribution of thermo-responsive magnetic complex micelles formed by Mn0.6Zn0.4Fe2O4 and a PCL/PEG analogue copolymer for controlled drug delivery.	copolymer	160-169	polycystic kidney disease 2-like 1	Mus musculus	143-146
27999834-4	2017	The structure of the C18/EA/SMCC/FITC-g-PSI copolymer was confirmed using 1H-NMR and FTIR spectroscopy, and its cell binding ability was investigated by flow cytometry and confocal laser scanning microscopy.	copolymer	44-53	Bardet-Biedl syndrome 9	Homo sapiens	21-24
27999834-4	2017	The structure of the C18/EA/SMCC/FITC-g-PSI copolymer was confirmed using 1H-NMR and FTIR spectroscopy, and its cell binding ability was investigated by flow cytometry and confocal laser scanning microscopy.	copolymer	44-53	transgelin	Homo sapiens	28-32
28000449-4	2017	Depending on the chemical reaction between the formic acid (FA) droplet template and the polyvinylpyridine (PVP) segments in copolymer, we successfully create nanoBFAs by casting a PVP-containing copolymer solution in CS2 in FA vapor.	copolymer	125-134	chorionic somatomammotropin hormone 2	Homo sapiens	218-221
28026935-3	2017	The copolymer was characterized by FTIR, NMR, and GPC.	copolymer	4-13	glycophorin C (Gerbich blood group)	Homo sapiens	50-53
32263548-1	2017	A thermo-responsive PCL/PEG analogue copolymer (PCL-[b-P(MEO2MA-co-OEGMA)]2) with a lower critical solution temperature (LCST) of 40.4  C at an MEO2MA/OEGMA molar ratio of 87 : 13 was designed and synthesized.	copolymer	37-46	polycystic kidney disease 2-like 1	Mus musculus	48-51
28872995-6	2017	The area was anaesthetized, cleaned and the dislodged bone was manually repositioned, followed by an EVA copolymer splint for fixation as a result of patient"s deep bite impeding regular wire-composite splint.	copolymer	105-114	myelin protein zero like 2	Homo sapiens	101-104
28051190-6	2017	Further, the CO2 selectivities of block copolymer with the best block proportion was studied by varying the crosslinking time which confirmed that the high crosslinking degree exhibited a better CO2/N2 (alphaCO2/N2) selectivities.	copolymer	40-49	complement C2	Homo sapiens	195-201
27933999-6	2016	The DARP- and Stille-derived copolymer and fullerene blend microstructural properties and morphologies are characterized with AFM, TEM, and XRD and are found to be virtually indistinguishable.	copolymer	29-38	ankyrin repeat domain 23	Homo sapiens	4-8
28854424-2	2017	METHODS: The isoelectric point (pI) of hHGF is 5.5, and hHGF combined with PEG-b-P(ELG-g-PLL) copolymer via electrostatic interactions at pH 7.4.	copolymer	94-103	hepatocyte growth factor	Homo sapiens	39-43
27936729-5	2016	We have also evaluated the tumor targeting molecular imaging ability of these branched copolymer nanoparticle in vivo using nude/NCr mice bearing AR42J rat pancreatic tumor (SSTR2 positive) and A549 human lung carcinoma tumor (SSTR2 negative) xenografts.	copolymer	87-96	somatostatin receptor 2	Rattus norvegicus	174-179
27936729-5	2016	We have also evaluated the tumor targeting molecular imaging ability of these branched copolymer nanoparticle in vivo using nude/NCr mice bearing AR42J rat pancreatic tumor (SSTR2 positive) and A549 human lung carcinoma tumor (SSTR2 negative) xenografts.	copolymer	87-96	somatostatin receptor 2	Homo sapiens	227-232
27933999-9	2016	For the DARP copolymer PBDTT-FTTE, the power conversion efficiency of 8.4% is a record for a DARP copolymer.	copolymer	13-22	ankyrin repeat domain 23	Homo sapiens	8-12
27933999-9	2016	For the DARP copolymer PBDTT-FTTE, the power conversion efficiency of 8.4% is a record for a DARP copolymer.	copolymer	13-22	ankyrin repeat domain 23	Homo sapiens	93-97
27933999-9	2016	For the DARP copolymer PBDTT-FTTE, the power conversion efficiency of 8.4% is a record for a DARP copolymer.	copolymer	98-107	ankyrin repeat domain 23	Homo sapiens	8-12
27933999-9	2016	For the DARP copolymer PBDTT-FTTE, the power conversion efficiency of 8.4% is a record for a DARP copolymer.	copolymer	98-107	ankyrin repeat domain 23	Homo sapiens	93-97
27580376-0	2016	A Heparin-Mimicking Block Copolymer Both Stabilizes and Increases the Activity of Fibroblast Growth Factor 2 (FGF2).	copolymer	26-35	fibroblast growth factor 2	Homo sapiens	82-108
27340892-2	2016	Herein, we report a new type of self-assembling block copolymer with changeable polymer backbone structure, poly(Fmoc-Ser)ester-b-PSt, which was synthesized by combining the polycondensation of 9-fluorenylmethoxycarbonyl-serine (Fmoc-Ser) with the reversible addition-fragmentation chain transfer (RAFT) polymerization of styrene (St).	copolymer	54-63	sulfotransferase family 1A member 1	Homo sapiens	130-133
27655431-1	2016	The present study reports construction of wound dressing materials from degradable natural polymers such as hydroxy derivatives of carboxylic acids (PHAs) and 3-hydroxybutyrate/4-hydroxybutyrate [P(3HB/4HB)] as copolymer.	copolymer	211-220	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	196-205
27565214-3	2016	Diffusion coefficients are obtained for acetazolamide, riboflavin, sodium fluorescein, and theophylline in 2-hydroxyethyl methacrylate/methacrylic acid (HEMA/MAA) copolymer hydrogels as functions of composition, equilibrium water content (30-90%), and aqueous pH (2 and 7.4).	copolymer	163-172	MAA	Homo sapiens	158-161
27474601-4	2016	The factors affecting the intrinsic viscosity and the yield of copolymer were studied, which showed that the optimum conditions for the synthesis of NCS-g-PAM were mAM:mNCS=8:1, 0.15g of initiator dosage, mCS:mTPP=4.5:1, 1min of ultrasonication time, 4h of illumination time, and 30min of stirring time.	copolymer	63-72	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	155-158
30974647-2	2016	The anodic copolymer P(BCz-co-ProDOT) with BCz/ProDOT-Me2 = 1/1 feed molar ratio showed high optical contrast (DeltaT%) and coloring efficiency (eta), measured as 52.5% and 153.5 cm2 C-1 at 748 nm, respectively.	copolymer	11-20	endothelin receptor type A	Homo sapiens	145-148
27615746-4	2016	The mechanical properties and the structure of the hydrogel were controlled by changing copolymer composition and the CNC-to-copolymer mass ratio.	copolymer	125-134	protein kinase cAMP-dependent type I regulatory subunit alpha	Homo sapiens	118-121
27580376-0	2016	A Heparin-Mimicking Block Copolymer Both Stabilizes and Increases the Activity of Fibroblast Growth Factor 2 (FGF2).	copolymer	26-35	fibroblast growth factor 2	Homo sapiens	110-114
27580376-4	2016	Here we report a heparin mimicking block copolymer, poly(styrenesulfonate-co-poly(ethylene glycol) methyl ether methacrylate)-b-vinyl sulfonate) (p(SS-co-PEGMA)-b-VS, that contains a segment that enhances the stability of FGF2 and one that binds to the FGF2 receptor.	copolymer	41-50	fibroblast growth factor 2	Homo sapiens	222-226
27580376-4	2016	Here we report a heparin mimicking block copolymer, poly(styrenesulfonate-co-poly(ethylene glycol) methyl ether methacrylate)-b-vinyl sulfonate) (p(SS-co-PEGMA)-b-VS, that contains a segment that enhances the stability of FGF2 and one that binds to the FGF2 receptor.	copolymer	41-50	fibroblast growth factor 2	Homo sapiens	253-257
27580376-6	2016	A cell study performed with a cell line lacking native heparan sulfate proteoglycans indicated that the conjugated block copolymer facilitated binding of FGF2 to its receptor similar to the addition of heparin to FGF2.	copolymer	121-130	fibroblast growth factor 2	Homo sapiens	154-158
29491778-7	2017	This PCL-(PI)2 macrophotoinitiator was used as a precursor in photoinduced free radical promoted cationic polymerization to synthesize an AB2-type miktoarm star copolymer consisting of poly(epsilon-caprolactone) (PCL, as A block) and poly(cyclohexene oxide) (PCHO, as B block), namely PCL(PCHO)2.	copolymer	161-170	PHD finger protein 1	Homo sapiens	285-295
27877240-5	2016	To synthesize this novel compound, polyethylene glycol was functionalized with thioketal linker-modified camptothecin (TL-CPT) and triphenylphosphonium to form the block copolymer, TL-CPT-PEG1K-TPP.	copolymer	170-179	choline phosphotransferase 1	Homo sapiens	122-125
27877240-6	2016	The ZnPc/CPT-TPPNPs was constructed for delivery of the photosensitizer Zinc phthalocyanine (ZnPc) by blending the block copolymer TL-CPT-PEG1K-TPP with 1, 2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy (polyethylene glycol)] (DSPE-PEG).Triphenylphosphine can accumulate selectively several hundred-fold within mitochondria.	copolymer	121-130	choline phosphotransferase 1	Homo sapiens	9-12
27372424-10	2016	Based on the biodistribution and SPECT/CT studies, the copolymer extended with the cathepsin S susceptible linker exhibited significantly faster clearance and lower non-target retention without compromising tumor targeting.	copolymer	55-64	cathepsin S	Homo sapiens	83-94
27343616-3	2016	In this work, branched copolymer modified hydrophilic material Sil@Poly(THMA-co-MBAAm), with high hydrophilicity and unique "claw-like" polyhydric groups, were prepared by "grafting from" thiol-ene click reaction.	copolymer	23-32	Scl/Tal1 interrupting locus	Mus musculus	63-66
27649562-5	2016	Results indicate that poly(ethylene glycol)-poly(beta-L-malic acid)-campotothecin-I (PEG-PMLA-CPT-I, P1) is a grafted copolymer, and could form star micelles in aqueous solution with a diameter of about 97 nm, also that PEG-PMLA-CPT-II (P2) is an amphiphilic block copolymer, and could form crew cut micelles with a diameter of about 76 nm.	copolymer	118-127	carnitine palmitoyltransferase 1A	Homo sapiens	94-99
26828415-1	2016	The purpose of this investigation is to design and synthesize novel pentablock (PB) copolymer (PB-1: PCL-PLA-PEG-PLA-PCL) based nanoformulations suspended in a thermosensitive gelling copolymer (PB-2: mPEG-PCL-PLA-PCL-PEGm) termed as composite nanoformulation.	copolymer	84-93	polybromo 1	Mus musculus	95-99
27251415-4	2016	Block copolymer degradation was studied by GPC.	copolymer	6-15	glycophorin C (Gerbich blood group)	Homo sapiens	43-46
27649562-5	2016	Results indicate that poly(ethylene glycol)-poly(beta-L-malic acid)-campotothecin-I (PEG-PMLA-CPT-I, P1) is a grafted copolymer, and could form star micelles in aqueous solution with a diameter of about 97 nm, also that PEG-PMLA-CPT-II (P2) is an amphiphilic block copolymer, and could form crew cut micelles with a diameter of about 76 nm.	copolymer	265-274	carnitine palmitoyltransferase 1A	Homo sapiens	94-99
27462904-0	2016	Surface Assembly Configurations and Packing Preferences of Fibrinogen Mediated by the Periodicity and Alignment Control of Block Copolymer Nanodomains.	copolymer	129-138	fibrinogen beta chain	Homo sapiens	59-69
27346726-6	2016	Ptx and 17-AAG present similar loading efficiencies in double loaded micelles probably due to interactions of drugs with each other and also with the copolymer.	copolymer	150-159	N-methylpurine DNA glycosylase	Homo sapiens	11-14
27409712-9	2016	Surface tensiometry studies and LDH release assays suggest that the PMPC-g-PHPMA graft copolymer exhibits surfactant-like activity.	copolymer	87-96	AT695_RS04475	Staphylococcus aureus	32-35
27045347-6	2016	The prepared poly(GMA-co-SBMA) with an optimum PGMA/PSBMA ratio of 0.23 and a molecular weight of 25kDa exhibited the best resistance to fibrinogen adsorption with over 90% reduction as well as blood cell activation, tissue cell adhesion and bacterial attachment on the zwitterionic copolymer grafted surfaces.	copolymer	283-292	androgen receptor	Homo sapiens	25-29
27092438-4	2016	According to the swelling- or shrinking-responses of the smart capping copolymer to temperature changes between 10 C and 40 C, the loading and releasing patterns of the model drug cytochrome c were studied in vitro.	copolymer	71-80	cytochrome c, somatic	Homo sapiens	180-192
32263611-3	2016	By incorporating nano-hydroxyapatite (HAp) into a shape memory copolymer poly(d,l-lactide-co-trimethylene carbonate) (PLMC) via co-electrospinning, composite nanofibers of HAp/PLMC with various HAp proportions (1, 2 and 3 wt%) were successfully generated.	copolymer	63-72	reticulon 3	Homo sapiens	38-41
27334427-1	2016	In our previous work, organic solvents, especially 1-butanol, play a key role to separate highly hydrophobic analytes in EKC using the polymeric micelle self-assembled from amphiphilic random copolymer poly (stearyl methacrylate-co-methyl acrylic acid) (P(SMA-co-MAA)) as a novel pseudostationary phase.	copolymer	192-201	survival of motor neuron 1, telomeric	Homo sapiens	256-259
27332148-3	2016	In this study, we prepared a nanovehicle for codelivery of photosensitizer (pyropheophorbide-a, PPa) and chemo-drugs (paclitaxel, PTX) based on the synthesis of PPa-conjugated amphiphilic copolymer PPa-PLA-PEG-PLA-PPa.	copolymer	188-197	preproenkephalin	Mus musculus	161-164
27467072-2	2016	In this study, we synthesized a pH-responsive comb-shaped block copolymer, polyethylene glycol monomethyl ether-epsilon-polylysine-g-poly (lactic acid) (PEP)to deliver protein (bovine serum albumin (BSA)).	copolymer	64-73	prolyl endopeptidase	Mus musculus	153-156
27332148-3	2016	In this study, we prepared a nanovehicle for codelivery of photosensitizer (pyropheophorbide-a, PPa) and chemo-drugs (paclitaxel, PTX) based on the synthesis of PPa-conjugated amphiphilic copolymer PPa-PLA-PEG-PLA-PPa.	copolymer	188-197	preproenkephalin	Mus musculus	161-164
27332148-3	2016	In this study, we prepared a nanovehicle for codelivery of photosensitizer (pyropheophorbide-a, PPa) and chemo-drugs (paclitaxel, PTX) based on the synthesis of PPa-conjugated amphiphilic copolymer PPa-PLA-PEG-PLA-PPa.	copolymer	188-197	preproenkephalin	Mus musculus	161-164
27421654-7	2016	These experimental groups included an untreated group, autograft, and groups treated with the synthesized copolymer carrying different concentrations of BMP-2 (0, 5, 10, and 20 mug/ml).	copolymer	106-115	bone morphogenetic protein 2	Oryctolagus cuniculus	153-158
27154500-0	2016	Synthesis of intracellular reduction-sensitive amphiphilic polyethyleneimine and poly(epsilon-caprolactone) graft copolymer for on-demand release of doxorubicin and p53 plasmid DNA.	copolymer	114-123	tumor protein p53	Homo sapiens	165-168
27154500-10	2016	Finally, the co-delivery of Dox and p53-pDNA using the copolymer displayed greater cytotoxic effect compared with the Dox-loaded nanoparticle counterpart as revealed by cell viability and Caspase 3 expression assay.	copolymer	55-64	tumor protein p53	Homo sapiens	36-39
27154500-10	2016	Finally, the co-delivery of Dox and p53-pDNA using the copolymer displayed greater cytotoxic effect compared with the Dox-loaded nanoparticle counterpart as revealed by cell viability and Caspase 3 expression assay.	copolymer	55-64	caspase 3	Homo sapiens	188-197
27154500-16	2016	In addition, the co-delivery of doxorubicin and p53 plasmid DNA using the new copolymer displayed greater cytotoxic effect compared with single agent (i.e. Dox) loaded counterpart, which indicated the significance of rapid dissociation of therapeutic agents from the carrier for synergistic cytotoxic effects on cancer cells.	copolymer	78-87	tumor protein p53	Homo sapiens	48-51
27259274-0	2016	Folate-targeted star-shaped cationic copolymer co-delivering docetaxel and MMP-9 siRNA for nasopharyngeal carcinoma therapy.	copolymer	37-46	matrix metallopeptidase 9	Homo sapiens	75-80
27305462-5	2016	Initially, targeted delivery of the graft copolymer was investigated by introducing a tumor specific ligand, anti-HER2/neu antibody, on the structure.	copolymer	42-51	erb-b2 receptor tyrosine kinase 2	Homo sapiens	114-118
27259274-2	2016	Based on our previous work, to co-deliver docetaxel (DOC) and MMP-9 siRNA more efficiently for HNE-1 nasopharyngeal carcinoma therapy, a folate-modified star-shaped copolymer (FA-CD-PLLD) consisting of beta-cyclodextrin (CD) and poly(L-lysine) dendron (PLLD) was synthesized, and then used for DOC and MMP-9 co-delivery.	copolymer	165-174	matrix metallopeptidase 9	Homo sapiens	62-67
27259274-2	2016	Based on our previous work, to co-deliver docetaxel (DOC) and MMP-9 siRNA more efficiently for HNE-1 nasopharyngeal carcinoma therapy, a folate-modified star-shaped copolymer (FA-CD-PLLD) consisting of beta-cyclodextrin (CD) and poly(L-lysine) dendron (PLLD) was synthesized, and then used for DOC and MMP-9 co-delivery.	copolymer	165-174	matrix metallopeptidase 9	Homo sapiens	302-307
27150702-7	2016	Furthermore, using the dual-functional random copolymer, CRP could be detected in a pooled blood serum diluted 100x with dramatic reduction of nonspecific adsorption.	copolymer	46-55	C-reactive protein	Homo sapiens	57-60
26991998-4	2016	Self-assembly of the amphiphilic PVEtImBr-b-PVOcImBr block copolymer, i.e., of PIL-b-PIL-type, rapidly takes place in water, forming polymer nanoparticles consisting of a hydrophilic PVEtImBr corona and a hydrophobic PVOcImBr core.	copolymer	59-68	methionine sulfoxide reductase B2	Homo sapiens	79-84
27470963-2	2016	METHODS: The copolymer folic acid-polyethylene glycol-polyethyleneimine (FA-PEG-PEI) was synthesized through amidation reaction, and then FA-PEG-PEI/ magnetic nanoparticles-CDDP/TFPI-2 (MNP-CDDP/TFPI-2) nanocomposites was obtained by electrostatic adsorption between TFPI-2 plasmid and magnetic nanoparticles loaded with CDDP (MNP-CDDP) with vortex FA-PEG-PEI.	copolymer	13-22	tissue factor pathway inhibitor 2	Homo sapiens	178-184
27470963-2	2016	METHODS: The copolymer folic acid-polyethylene glycol-polyethyleneimine (FA-PEG-PEI) was synthesized through amidation reaction, and then FA-PEG-PEI/ magnetic nanoparticles-CDDP/TFPI-2 (MNP-CDDP/TFPI-2) nanocomposites was obtained by electrostatic adsorption between TFPI-2 plasmid and magnetic nanoparticles loaded with CDDP (MNP-CDDP) with vortex FA-PEG-PEI.	copolymer	13-22	tissue factor pathway inhibitor 2	Homo sapiens	195-201
27470963-2	2016	METHODS: The copolymer folic acid-polyethylene glycol-polyethyleneimine (FA-PEG-PEI) was synthesized through amidation reaction, and then FA-PEG-PEI/ magnetic nanoparticles-CDDP/TFPI-2 (MNP-CDDP/TFPI-2) nanocomposites was obtained by electrostatic adsorption between TFPI-2 plasmid and magnetic nanoparticles loaded with CDDP (MNP-CDDP) with vortex FA-PEG-PEI.	copolymer	13-22	tissue factor pathway inhibitor 2	Homo sapiens	195-201
27108402-7	2016	In conclusion, in vitro and in vivo results presented here demonstrate that nDP modified copolymer scaffolds are able to decrease the tumorigenic potential of DOK(Luc), while confirming concerns for the therapeutic use of BMP-2 for reconstruction of bone defects in oral cancer patients due to its tumour promoting capabilities.	copolymer	89-98	norrin cystine knot growth factor NDP	Homo sapiens	76-79
27108402-7	2016	In conclusion, in vitro and in vivo results presented here demonstrate that nDP modified copolymer scaffolds are able to decrease the tumorigenic potential of DOK(Luc), while confirming concerns for the therapeutic use of BMP-2 for reconstruction of bone defects in oral cancer patients due to its tumour promoting capabilities.	copolymer	89-98	bone morphogenetic protein 2	Homo sapiens	222-227
32264618-4	2016	Particularly, the lower critical solution temperature (LCST) of the copolymer was adjusted to human physiological temperature by the optimal comonomer ratio of MAA.	copolymer	68-77	MAA	Homo sapiens	160-163
26928528-1	2016	We previously developed a "cage"-like nano-formulation (nanozyme) for copper/Zinc superoxide dismutase (SOD1) by polyion condensation with a conventional block copolymer poly(ethylene glycol)-b-poly(L-lysine) (PEG-PLL) followed by chemical cross-linking.	copolymer	160-169	superoxide dismutase 1, soluble	Mus musculus	104-108
27153187-2	2016	Herein, to realize the codelivery of docetaxel and MMP-9 siRNA plasmid efficiently into tumor cells, a star-shaped amphiphilic copolymer consisting of hyperbranched polyglycerol derivative (HPG-C18) and dendritic poly(l-lysine) (PLLD) was synthesized by the click reaction between azido-modified HPG-C18 and propargyl focal point PLLD.	copolymer	127-136	matrix metallopeptidase 9	Homo sapiens	51-56
27427584-2	2016	In this study, a well-defined block copolymer synthesized via ATRP, i.e., poly(ethylene glycol)-b-poly(2-diisopropylaminoethyl methacrylate) (PEG-b-PDPA), has been used to investigate the insulin release behavior in response to glucose changes for potential diabetes mellitus (DM) therapy.	copolymer	36-45	insulin	Homo sapiens	188-195
26924362-0	2016	Polydopamine-assisted BMP-2-derived peptides immobilization on biomimetic copolymer scaffold for enhanced bone induction in vitro and in vivo.	copolymer	74-83	bone morphogenetic protein 2	Rattus norvegicus	22-27
27145021-6	2016	The best copolymer, PEG2k-pp-PE, showed even higher P-gp inhibition effect than the d-alpha-tocopherol polyethylene glycol 1000 succinate (TPGS1k).	copolymer	9-18	ATP binding cassette subfamily B member 1	Homo sapiens	52-56
27001892-4	2016	The VEGFR-1-targeted copolymer was tested for its binding, internalization and in vitro cytotoxicity in ECs (bEnd.3 and cEND cells) and cancer cells (B16-F10, 3LL and HT29).	copolymer	21-30	PDGF- and VEGF-receptor related	Drosophila melanogaster	4-9
26930541-8	2016	Finally, alkynyl functional hyaluronic acid (HA-BP) and nitrine functional chitosan (CS-N3) were synthesized and covalently cross-linked to copolymer hydrogel surface using LbL technique through click chemistry.	copolymer	140-149	casein kappa	Homo sapiens	85-90
27065050-1	2016	The interaction of human serum albumin (HSA) with amphiphilic block copolymer Pluronic F127 has been investigated by several physical methods.	copolymer	68-77	albumin	Homo sapiens	25-38
27100328-2	2016	In this report, we prepare the copolymer prodrugs (PPEMA-co-PCPTM) via reversible addition-fragmentation chain transfer (RAFT) polymerization of 2-(piperidin-1-yl)ethyl methacrylate (PEMA) and reduction-responsive CPT monomer (CPTM), which were quantitatively encapsulated into poly(ethylene glycol)-block-poly(epsilon-caprolactone) (PEG-b-PCL) micelles.	copolymer	31-40	choline phosphotransferase 1	Homo sapiens	61-64
27340484-3	2016	In this paper, a graft copolymer (hyperbranched polystyrene)-g-poly[2-(dimethylamino)ethyl methacrylate] (HBPS-g-PDMAEMA) was synthesized and characterized by (1)H NMR and GPC.	copolymer	23-32	glycophorin C (Gerbich blood group)	Homo sapiens	172-175
30979280-6	2016	The ODT is much lower than that of the coil-coil diblock copolymer system and the triple point at which disordered, cylinder and lamella phases coexist in equilibrium is located at rod composition fR = 0.66.	copolymer	57-66	kinetochore associated 1	Homo sapiens	181-184
27001892-4	2016	The VEGFR-1-targeted copolymer was tested for its binding, internalization and in vitro cytotoxicity in ECs (bEnd.3 and cEND cells) and cancer cells (B16-F10, 3LL and HT29).	copolymer	21-30	BEN domain containing 3	Mus musculus	109-115
27001892-7	2016	Accordingly, the VEGFR-1-targeted copolymer (P-(F56)-DOX) was more toxic towards bEnd.3 cells than to cancer cells, and exhibited significantly higher cytotoxicity than did the non-targeted control copolymer.	copolymer	34-43	FMS-like tyrosine kinase 1	Mus musculus	17-24
27001892-7	2016	Accordingly, the VEGFR-1-targeted copolymer (P-(F56)-DOX) was more toxic towards bEnd.3 cells than to cancer cells, and exhibited significantly higher cytotoxicity than did the non-targeted control copolymer.	copolymer	34-43	BEN domain containing 3	Mus musculus	81-87
27001892-7	2016	Accordingly, the VEGFR-1-targeted copolymer (P-(F56)-DOX) was more toxic towards bEnd.3 cells than to cancer cells, and exhibited significantly higher cytotoxicity than did the non-targeted control copolymer.	copolymer	198-207	FMS-like tyrosine kinase 1	Mus musculus	17-24
26703197-2	2016	The PEG-click-PPG copolymer can self-assemble into spherical micelles in aqueous solution.	copolymer	18-27	serglycin	Homo sapiens	14-17
26952455-0	2016	Effect of cationic grafted copolymer structure on the encapsulation of bovine serum albumin.	copolymer	27-36	albumin	Homo sapiens	78-91
26952460-0	2016	Comb-like amphiphilic polypeptide-based copolymer nanomicelles for co-delivery of doxorubicin and P-gp siRNA into MCF-7 cells.	copolymer	40-49	phosphoglycolate phosphatase	Homo sapiens	98-102
33440481-5	2016	In this study, the block copolymer with the shortest AEMA segment was the most effective in EGFR gene silencing, however this block copolymer revealed to be slightly more toxic as compared to the statistical copolymers studied at higher w/w ratios.	copolymer	25-34	epidermal growth factor	Homo sapiens	92-96
26812966-3	2016	METHODS: The objectives of this study were to develop and characterize in vitro a novel poly-L-lysine (PLL) and polyethylene glycol (PEG) copolymer-based NP containing fluorescent-tagged bovine serum albumin (BSA), and conjugated with ERY1, a 12 amino acid peptide with high affinity for the RBC membrane protein glycophorin A (ENP).	copolymer	138-147	albumin	Homo sapiens	194-207
26812966-3	2016	METHODS: The objectives of this study were to develop and characterize in vitro a novel poly-L-lysine (PLL) and polyethylene glycol (PEG) copolymer-based NP containing fluorescent-tagged bovine serum albumin (BSA), and conjugated with ERY1, a 12 amino acid peptide with high affinity for the RBC membrane protein glycophorin A (ENP).	copolymer	138-147	glycophorin A (MNS blood group)	Homo sapiens	313-326
26703197-3	2016	It is found that high intensity focused ultrasound (HIFU) can open the copolymer PEG-click-PPG micelles and trigger the release of the payload in the micelle.	copolymer	71-80	serglycin	Homo sapiens	91-94
26926103-2	2016	Here, we synthesized a smart polypeptide copolymer based on n-butylamine-poly(L-lysine)-b-poly(L-cysteine) (PLL-PLC) with functionalization of folic acid (FA) and 1,2-dicarboxylic-cyclohexene anhydride (DCA) for multistage responsive tumor-targeted drug delivery.	copolymer	41-50	heparan sulfate proteoglycan 2	Homo sapiens	112-115
27022665-3	2016	The unfolding and refolding behaviors of lysozyme molecules in the presence of the copolymer were studied by microcalorimetry and circular dichroism spectroscopy.	copolymer	83-92	lysozyme	Homo sapiens	41-49
27022665-5	2016	Compared with its native state, this copolymer-complexed new folding state of lysozyme has different secondary and tertiary structures, a decreased thermostability, and significantly altered unfolding/refolding behaviors.	copolymer	37-46	lysozyme	Homo sapiens	78-86
26700649-4	2016	The present study reveals that the hydrophobic part PPG of the copolymer has more influence on this behavior than the PEG hydrophilic part.	copolymer	63-72	serglycin	Homo sapiens	52-55
26853449-0	2016	In Vivo Host Response and Degradation of Copolymer Scaffolds Functionalized with Nanodiamonds and Bone Morphogenetic Protein 2.	copolymer	41-50	bone morphogenetic protein 2	Mus musculus	98-126
26864651-5	2016	Interestingly, the content of CD133 + CXCR4+ cells in HCT116 cancer cells and RKO cells treated by 5-Fu/P85 copolymer micelles was decreased.	copolymer	108-117	prominin 1	Homo sapiens	30-35
26864651-5	2016	Interestingly, the content of CD133 + CXCR4+ cells in HCT116 cancer cells and RKO cells treated by 5-Fu/P85 copolymer micelles was decreased.	copolymer	108-117	C-X-C motif chemokine receptor 4	Homo sapiens	38-43
26864651-6	2016	Importantly, the epithelial-mesenchymal transition (EMT) of CD133 + CXCR4+ cells, which was strongly associated with liver metastasis of colon cancer, was also suppressed by giving 5-Fu/P85 copolymer micelles.	copolymer	190-199	prominin 1	Homo sapiens	60-65
26864651-6	2016	Importantly, the epithelial-mesenchymal transition (EMT) of CD133 + CXCR4+ cells, which was strongly associated with liver metastasis of colon cancer, was also suppressed by giving 5-Fu/P85 copolymer micelles.	copolymer	190-199	C-X-C motif chemokine receptor 4	Homo sapiens	68-73
26864651-7	2016	The results indicated that 5-Fu/P85 copolymer micelles could inhibit the growth and metastasis of colon cancer, which could be attributed to the decrease of the content of CD133 + CXCR4+ cells and suppression of EMT of CD133 + CXCR4+ cells.	copolymer	36-45	prominin 1	Homo sapiens	172-177
26864651-7	2016	The results indicated that 5-Fu/P85 copolymer micelles could inhibit the growth and metastasis of colon cancer, which could be attributed to the decrease of the content of CD133 + CXCR4+ cells and suppression of EMT of CD133 + CXCR4+ cells.	copolymer	36-45	C-X-C motif chemokine receptor 4	Homo sapiens	180-185
26864651-7	2016	The results indicated that 5-Fu/P85 copolymer micelles could inhibit the growth and metastasis of colon cancer, which could be attributed to the decrease of the content of CD133 + CXCR4+ cells and suppression of EMT of CD133 + CXCR4+ cells.	copolymer	36-45	prominin 1	Homo sapiens	219-224
26864651-7	2016	The results indicated that 5-Fu/P85 copolymer micelles could inhibit the growth and metastasis of colon cancer, which could be attributed to the decrease of the content of CD133 + CXCR4+ cells and suppression of EMT of CD133 + CXCR4+ cells.	copolymer	36-45	C-X-C motif chemokine receptor 4	Homo sapiens	227-232
32263369-4	2016	Here, chitosan-polyethyleneimine (PEI, Mw 1800) copolymer nanoparticles were synthesized as nanocarriers to deliver Gab2 siRNA into SKOV3 cells.	copolymer	48-57	GRB2 associated binding protein 2	Homo sapiens	116-120
26636714-2	2016	The resulting PEG5K-VE4-DET20 copolymer formed nanoassemblies when mixed with the neutral PEG5K-VE4 copolymer at 1:8 weight ratio, which were investigated as the nanocarriers for combined delivery of paclitaxel and let-7b mimic.	copolymer	30-39	microRNA let7b	Mus musculus	215-221
26735344-8	2016	The copolymer film with the longest PEO sequence (PEO2000) and highest PEO weight content (60%) showed a measured CO2 pure gas permeability of 39 Barrer, and ideal CO2/H2 and CO2/N2 selectivities of 4.1 and 46, respectively, at 35  C and 3 atm, making them attractive for hydrogen purification and carbon capture.	copolymer	4-13	complement C2	Homo sapiens	175-209
26808122-0	2016	Adenoviral Mediated Expression of BMP2 by Bone Marrow Stromal Cells Cultured in 3D Copolymer Scaffolds Enhances Bone Formation.	copolymer	83-92	bone morphogenetic protein 2	Mus musculus	34-38
26572349-6	2016	The hydrodynamic radius (Rh) of the copolymer micelles was also influenced by the ratio of DMAEMA to MEO2MA and the stimuli of temperature and CO2/Ar.	copolymer	36-45	complement C2	Homo sapiens	143-149
26296988-4	2016	The polymer, abbreviated as PTH, is composed of a poly-(N,N,N",N"-tetraethyldiethylenetriamine, N-(2-hydroxypropyl) methacrylamide, TEDETAMA-co-HPMA (50:50) copolymer.	copolymer	157-166	parathyroid hormone	Homo sapiens	28-31
26653672-0	2016	Encapsulation of MEH-PPV:PCBM Hybrids in the Cores of Block Copolymer Micellar Assemblies: Photoinduced Electron Transfer in a Nanoscale Donor-Acceptor System.	copolymer	60-69	epoxide hydrolase 1	Homo sapiens	17-20
26213086-4	2016	At second stage, the copolymer-rich phase was treated with the acidic solution, and Pb(II) was back extracted into the aqueous phase.	copolymer	21-30	submaxillary gland androgen regulated protein 3B	Homo sapiens	84-90
26641134-3	2016	In this study, an amphiphilic and biodegradable ternary copolymer conjugated with folate as ligand, polyethylenimine-graft-polycaprolactone-block-poly(ethylene glycol)-folate (PEI-PCL-PEG-Fol) was synthesized and evaluated for targeted siRNA delivery via folate-FR recognition.	copolymer	56-65	PHD finger protein 1	Homo sapiens	180-183
25020049-0	2016	Gene silencing effect of SiRNA-magnetic modified with biodegradable copolymer nanoparticles on hTERT gene expression in lung cancer cell line.	copolymer	68-77	telomerase reverse transcriptase	Homo sapiens	95-100
26524535-5	2016	miR-29b1 and GDC-0449 were co-formulated into micelles using methoxy poly(ethylene glycol)-block-poly(2-methyl-2-carboxyl-propylene carbonate-graft-dodecanol-graft-tetraethylenepentamine) (mPEG-b-PCC-g-DC-g-TEPA) copolymer, and injected systemically into CBDL mice.	copolymer	213-222	microRNA 29b-1	Mus musculus	0-8
26616587-2	2015	The work was aimed at investigating the suitability of using P123 as bile salt sequestrant beside the fundamental aspects of PEO-PPO-PEO block copolymer-bile salt interactions.	copolymer	143-152	protoporphyrinogen oxidase	Homo sapiens	129-132
27301173-1	2016	A series of novel polypeptide-based graft copolymer poly(L-glutamic acid)-graft-methoxy poly(ethylene glycol) (PLG-g-mPEG) was synthesized through a Steglich esterification reaction of PLG with mPEG.	copolymer	42-51	plasminogen	Homo sapiens	111-114
27301173-1	2016	A series of novel polypeptide-based graft copolymer poly(L-glutamic acid)-graft-methoxy poly(ethylene glycol) (PLG-g-mPEG) was synthesized through a Steglich esterification reaction of PLG with mPEG.	copolymer	42-51	plasminogen	Homo sapiens	185-188
26634441-4	2015	Here, we report the 4 angstrom resolution cryogenic electron microscopy reconstruction of a one-start, double-stranded helical copolymer composed of two different human ESCRT-III subunits, charged multivesicular body protein 1B (CHMP1B) and increased sodium tolerance 1 (IST1).	copolymer	127-136	charged multivesicular body protein 1B	Homo sapiens	189-227
26572500-1	2015	A novel strategy has been adopted for the construction of a copolymer of benzene-benzylamine-1 (BBA-1), which is a porous organic polymer (POP) with a high BET surface area, through Friedel-Crafts alkylation of benzylamine and benzene by using formaldehyde dimethyl acetal as a cross-linker and anhydrous FeCl3 as a promoter.	copolymer	60-69	delta/notch like EGF repeat containing	Homo sapiens	156-159
26634441-4	2015	Here, we report the 4 angstrom resolution cryogenic electron microscopy reconstruction of a one-start, double-stranded helical copolymer composed of two different human ESCRT-III subunits, charged multivesicular body protein 1B (CHMP1B) and increased sodium tolerance 1 (IST1).	copolymer	127-136	charged multivesicular body protein 1B	Homo sapiens	229-235
26634441-4	2015	Here, we report the 4 angstrom resolution cryogenic electron microscopy reconstruction of a one-start, double-stranded helical copolymer composed of two different human ESCRT-III subunits, charged multivesicular body protein 1B (CHMP1B) and increased sodium tolerance 1 (IST1).	copolymer	127-136	IST1 factor associated with ESCRT-III	Homo sapiens	271-275
26433365-3	2015	The authors first prepared a dopamine and hexamethylendiamine (PDAM/HD) amine-rich adherent copolymer coating to introduce amine groups onto 316L stainless steel, followed by covalently conjugating 3,3-disulfodipropionic acid (S-S) and 3,3-diselenodipropionic acid (Se-Se), which mimic glutathione peroxidase-like catalytic production of NO.	copolymer	92-101	TP73 antisense RNA 1	Homo sapiens	63-67
26435266-1	2015	A poly(3,4-ethylenedioxythiophene)-b-poly(ethylene glycol) (PEDOT-b-PEG) block copolymer doped with perchlorate on FTO shows excellent optical and interfacial performance as a counter electrode (CE), such as low charge transfer resistance and low reflectivity for polymer electrolyte-based solid-state dye-sensitized solar cells (DSCs), resulting in 8.45% energy conversion efficiency, greater than the common Pt CE, via a facile room-temperature process.	copolymer	79-88	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	115-118
26612727-3	2015	The enteric copolymer poly(methacrylic acid-co-methyl methacrylate) 1:2 (MMA) has been designed for drug delivery although its chemical properties allow to use it for other applications.	copolymer	12-21	monocyte to macrophage differentiation associated	Homo sapiens	73-76
26456723-4	2015	Retarded protein migration into acrylamide gels stained for BChE activity was noted with all copolymers as the copolymer-to-protein ratio was increased.	copolymer	93-102	butyrylcholinesterase	Homo sapiens	60-64
26456723-8	2015	BChE activity was higher in C-BCs made with the medium and low compared to high MW-based copolymer.	copolymer	89-98	butyrylcholinesterase	Homo sapiens	0-4
26280750-0	2015	Disorder to Order Transition and Ordered Morphology of Coil-Comb Block Copolymer by Self-Consistent Field Theory.	copolymer	71-80	coilin	Homo sapiens	55-59
26280750-2	2015	The phase diagrams of coil-comb copolymer are obtained by varying the composition of the copolymer with the side chain number m = 1, 2, and 3.	copolymer	32-41	coilin	Homo sapiens	22-26
26280750-2	2015	The phase diagrams of coil-comb copolymer are obtained by varying the composition of the copolymer with the side chain number m = 1, 2, and 3.	copolymer	89-98	coilin	Homo sapiens	22-26
26708887-4	2015	RESULTS: The apoptosis rate of SKM-1 cells in the copolymer groups was higher than that in both MNPs-Fe(3)O(4) and artesunate groups alone.	copolymer	50-59	sodium voltage-gated channel alpha subunit 4	Homo sapiens	31-36
26393413-5	2015	The orientation analysis revealed that the orientation of the fibrinogen adsorbed on the OMe-PRX-PMB surface is close to a single distribution, which is different from the adsorption behaviors of fibrinogen on other polyrotaxane or random copolymer surfaces.	copolymer	239-248	fibrinogen beta chain	Homo sapiens	62-72
26297207-6	2015	In addition, mice pretreated with an E-selectin-targeted "drug-free" copolymer (P-(Esbp)-FITC) exhibited significantly fewer B16-F10 tumor foci in the lungs as compared with non-treated mice, demonstrating the anti-metastatic properties of the copolymer and its ability to control cancer spread through E-selectin-mediated interactions.	copolymer	69-78	selectin, endothelial cell	Mus musculus	37-47
26297207-6	2015	In addition, mice pretreated with an E-selectin-targeted "drug-free" copolymer (P-(Esbp)-FITC) exhibited significantly fewer B16-F10 tumor foci in the lungs as compared with non-treated mice, demonstrating the anti-metastatic properties of the copolymer and its ability to control cancer spread through E-selectin-mediated interactions.	copolymer	69-78	selectin, endothelial cell	Mus musculus	303-313
26297207-6	2015	In addition, mice pretreated with an E-selectin-targeted "drug-free" copolymer (P-(Esbp)-FITC) exhibited significantly fewer B16-F10 tumor foci in the lungs as compared with non-treated mice, demonstrating the anti-metastatic properties of the copolymer and its ability to control cancer spread through E-selectin-mediated interactions.	copolymer	244-253	selectin, endothelial cell	Mus musculus	37-47
26297207-7	2015	Biodistribution analysis further confirmed the preferential accumulation of the E-selectin-targeted near-infrared fluorescently-labeled copolymer P-(Esbp)-IR783 in B16-F10 lung metastases.	copolymer	136-145	selectin, endothelial cell	Mus musculus	80-90
26297207-8	2015	Taken together, this study demonstrates, for the first time, that the E-selectin targeted copolymer-drug conjugates can inhibit primary tumor growth and prevent metastases in vivo.	copolymer	90-99	selectin, endothelial cell	Mus musculus	70-80
26194248-0	2015	Effect of Knockout of Mdr1a and Mdr1b ABCB1 Genes on the Systemic Exposure of a Doxorubicin-Conjugated Block Copolymer in Mice.	copolymer	109-118	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	22-27
26289407-3	2015	The resultant open tubular capillary column immobilized with the copolymer layer was used for the separation of tryptic digest of cytochrome C in capillary electrochromatography.	copolymer	65-74	cytochrome c, somatic	Homo sapiens	130-142
26194248-0	2015	Effect of Knockout of Mdr1a and Mdr1b ABCB1 Genes on the Systemic Exposure of a Doxorubicin-Conjugated Block Copolymer in Mice.	copolymer	109-118	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	32-37
26194248-0	2015	Effect of Knockout of Mdr1a and Mdr1b ABCB1 Genes on the Systemic Exposure of a Doxorubicin-Conjugated Block Copolymer in Mice.	copolymer	109-118	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	38-43
25912841-2	2015	The original synthetic fouling-resistant copolymer, poly(vinylpyrrolidone)-co-poly(sulfobetaine methacrylate) (poly(VP-co-SBMA)), is both thermal-tolerant and fouling-resistant, and the antifouling stability of copolymer coated interfaces can be effectively controlled by regulating the VP/SBMA composition ratio.	copolymer	41-50	androgen receptor	Homo sapiens	122-126
26106797-3	2015	Firstly, methoxy polyethylene glycol-peptide-vitamin E succinate (PPV), a matrix metalloproteinases (MMPs)-sensitive copolymer, was synthesized by conjugating mPEG and vitamin E succinate (VES) using an enzyme-sensitive peptide.	copolymer	117-126	matrix metallopeptidase 9	Mus musculus	101-105
26225535-0	2015	Controlled Assembly of Fibronectin Nanofibrils Triggered by Random Copolymer Chemistry.	copolymer	67-76	fibronectin 1	Mus musculus	23-34
26369118-1	2015	Block copolymer composed of carboxymethyl dextran (CMDex) and methoxy poly(ethylene glycol) (MPEG) (abbreviated as CMDexPEG) was synthesized and doxorubicin (DOX) was conjugated with carboxyl groups of CMDexPEG.	copolymer	6-15	aggrecan	Mus musculus	115-123
26369118-2	2015	DOX-conjugated CMDexPEG block copolymer formed nanoparticles in water with sizes less than 100 nm.	copolymer	30-39	aggrecan	Mus musculus	15-23
25958846-3	2015	The fullerene building blocks coassemble with a liquid-crystalline block copolymer to produce a highly ordered covalent fullerene framework with orthorhombic Fmmm symmetry, accessible 7.5 nm pores, and high surface area, as revealed by gas adsorption, NMR spectroscopy, small-angle X-ray scattering (SAXS), and TEM.	copolymer	73-82	MFT2	Homo sapiens	311-314
26085565-10	2015	RESULTS: PHEMA-co-AAm copolymer hydrogels (75:25 HEMA:AAm) yielded the most even GOx and dye dispersion throughout the hydrogel matrix and best preserved GOx apparent activity.	copolymer	22-31	hydroxyacid oxidase 1	Homo sapiens	81-84
26085565-10	2015	RESULTS: PHEMA-co-AAm copolymer hydrogels (75:25 HEMA:AAm) yielded the most even GOx and dye dispersion throughout the hydrogel matrix and best preserved GOx apparent activity.	copolymer	22-31	hydroxyacid oxidase 1	Homo sapiens	154-157
25569871-1	2015	We report a label-free aptasensor to make direct detection of prostate specific antigen (PSA, a biomarker of prostate cancer) using a quinone-containing conducting copolymer acting as redox transducer and grafting matrix for immobilization of the short aptamer strands.	copolymer	164-173	kallikrein related peptidase 3	Homo sapiens	62-87
25569871-1	2015	We report a label-free aptasensor to make direct detection of prostate specific antigen (PSA, a biomarker of prostate cancer) using a quinone-containing conducting copolymer acting as redox transducer and grafting matrix for immobilization of the short aptamer strands.	copolymer	164-173	kallikrein related peptidase 3	Homo sapiens	89-92
26178137-1	2015	The unit-cell size and pore diameter as functions of temperature are investigated in the syntheses of FDU-12 silicas with face-centered cubic structure templated by Pluronic (PEO-PPO-PEO) block copolymer micelles swollen by toluene.	copolymer	194-203	protoporphyrinogen oxidase	Homo sapiens	179-182
25689362-3	2015	Poly(ethylene glycol) and aliphatic chain (C18) were conjugated onto PAHy to afford an amphiphilic copolymer with acid-liable hydrazone bonds.	copolymer	99-108	Bardet-Biedl syndrome 9	Homo sapiens	43-46
26140987-2	2015	In order to down-regulate HMGB1 expression in airway epithelial cells, siRNA directed against HMGB1 was delivered through nanocomplexes based on a cationic copolymer of poly(N-2-hydroxyethyl)-d,l-aspartamide (PHEA) by using H441 cells.	copolymer	156-165	high mobility group box 1	Homo sapiens	94-99
25912841-2	2015	The original synthetic fouling-resistant copolymer, poly(vinylpyrrolidone)-co-poly(sulfobetaine methacrylate) (poly(VP-co-SBMA)), is both thermal-tolerant and fouling-resistant, and the antifouling stability of copolymer coated interfaces can be effectively controlled by regulating the VP/SBMA composition ratio.	copolymer	41-50	androgen receptor	Homo sapiens	290-294
25965552-3	2015	We report here the use of a linear polyethyleneimine (LPEI)-g-polyethylene glycol (PEG) copolymer-based micellar nanoparticle system to deliver siRNA targeting BACE1 and APP, two therapeutic targets of AD.	copolymer	88-97	beta-site APP cleaving enzyme 1	Mus musculus	160-165
33429519-0	2015	Drug-Loaded Star-Shaped pH-Responsive Monomolecular Copolymer Nanocarriers for Tumor Targeting and Cancer Therapy.	copolymer	52-61	steroidogenic acute regulatory protein	Homo sapiens	12-16
25811409-3	2015	It is shown that the hydrophilic segments (PEO) of the conjugated block copolymer molecules tend to entangle around the hydrophilic patch of Cyt c, while the hydrophobic segments (PPO) extend into the toluene.	copolymer	72-81	cytochrome c, somatic	Homo sapiens	141-146
25811409-3	2015	It is shown that the hydrophilic segments (PEO) of the conjugated block copolymer molecules tend to entangle around the hydrophilic patch of Cyt c, while the hydrophobic segments (PPO) extend into the toluene.	copolymer	72-81	protoporphyrinogen oxidase	Homo sapiens	180-183
25679326-6	2015	This copolymer self-assembled into micelles of <100 nm and encapsulated hydrophobic GDC-0449 into its core with 5% w/w drug loading and allowed complex formation between miR-let7b and its cationic pendant chains.	copolymer	5-14	membrane associated ring-CH-type finger 8	Homo sapiens	173-176
25679326-6	2015	This copolymer self-assembled into micelles of <100 nm and encapsulated hydrophobic GDC-0449 into its core with 5% w/w drug loading and allowed complex formation between miR-let7b and its cationic pendant chains.	copolymer	5-14	microRNA let-7b	Homo sapiens	177-182
25668064-2	2015	We use block copolymer micellar nanolithography to fabricate substrates with precisely spaced and tunable gold nanoparticle arrays carrying single BMP-2 molecules.	copolymer	13-22	bone morphogenetic protein 2	Homo sapiens	147-152
25867524-3	2015	Thermal treatment of copolymer films at 200  C for 10 min resulted in elimination of t-Boc side groups in nearly quantitative yield as suggested by thermogravimetric analysis and Fourier transform infrared spectroscopy.	copolymer	21-30	BOC cell adhesion associated, oncogene regulated	Homo sapiens	87-90
25787735-4	2015	In this study, retinoic acid (RA) and brain-derived neurotrophic factor (BDNF) were encapsulated into a copolymer of epsilon-caprolactone and ethyl ethylene phosphate to form a multifunctional, electrospun nanofibrous scaffold.	copolymer	104-113	brain derived neurotrophic factor	Mus musculus	38-71
25787735-4	2015	In this study, retinoic acid (RA) and brain-derived neurotrophic factor (BDNF) were encapsulated into a copolymer of epsilon-caprolactone and ethyl ethylene phosphate to form a multifunctional, electrospun nanofibrous scaffold.	copolymer	104-113	brain derived neurotrophic factor	Mus musculus	73-77
25668397-2	2015	One can control the size of spontaneously formed vesicles in mixtures of zwitterionic and anionic surfactants by the admixture of small amounts of an amphiphilic copolymer of the PEO-PPO-PEO type.	copolymer	162-171	protoporphyrinogen oxidase	Homo sapiens	183-186
25723546-5	2015	We focused on the interaction between an ethyl methacrylate/methyl acrylate 70:30 copolymer film deposited onto a glass surface and a water/nonionic surfactant/2-butanone (MEK) ternary system, with MEK being a good solvent and water being a nonsolvent for the polymer.	copolymer	82-91	mitogen-activated protein kinase kinase 7	Homo sapiens	172-175
33429519-3	2015	A four-armed star copolymer, tetra-(methoxy-poly(ethylene glycol)-poly(2-(N,N-diethylamino)ethyl methacrylate)-poly(epsilon-caprolactone) pentaerythritol ((mPEG-pDEA-PCL)4-PET, PDCP), was synthesized via the ring-opening polymerization, atom transfer radical polymerization and click chemistry, which formed a monomolecular nanocarrier in water.	copolymer	18-27	steroidogenic acute regulatory protein	Homo sapiens	13-17
25498622-4	2015	The obtained CS-g-PLA copolymer was able to self-assemble into about 14 nm micelles in water at low concentration, and beta-C loaded micelles (beta-C/M) had low beta-C degradation after 15 days.	copolymer	22-31	colony stimulating factor 2 receptor subunit beta	Homo sapiens	119-125
33429519-3	2015	A four-armed star copolymer, tetra-(methoxy-poly(ethylene glycol)-poly(2-(N,N-diethylamino)ethyl methacrylate)-poly(epsilon-caprolactone) pentaerythritol ((mPEG-pDEA-PCL)4-PET, PDCP), was synthesized via the ring-opening polymerization, atom transfer radical polymerization and click chemistry, which formed a monomolecular nanocarrier in water.	copolymer	18-27	phosphodiesterase 6A	Homo sapiens	161-165
25498622-4	2015	The obtained CS-g-PLA copolymer was able to self-assemble into about 14 nm micelles in water at low concentration, and beta-C loaded micelles (beta-C/M) had low beta-C degradation after 15 days.	copolymer	22-31	colony stimulating factor 2 receptor subunit beta	Homo sapiens	143-149
26697135-3	2015	The nanozyme is produced by electrostatic coupling of the SOD1 with a cationic block copolymer, poly(L-lysine)-poly(ethyleneglycol), followed by covalent cross-linking of the complexes with 3,3"-dithiobis(sulfosuccinimidylpropionate) sodium salt.	copolymer	85-94	superoxide dismutase [Cu-Zn]	Oryctolagus cuniculus	58-62
25498622-4	2015	The obtained CS-g-PLA copolymer was able to self-assemble into about 14 nm micelles in water at low concentration, and beta-C loaded micelles (beta-C/M) had low beta-C degradation after 15 days.	copolymer	22-31	colony stimulating factor 2 receptor subunit beta	Homo sapiens	143-149
25500961-1	2015	We proposed a block copolymer, poly(dihydroxystyrene-block-styrene) (PDHSt-b-PSt), that contains catechol groups in the side chains of PDHSt moieties.	copolymer	20-29	sulfotransferase family 1A member 1	Homo sapiens	77-80
25619193-0	2015	ABC triblock copolymer micelles: spherical versus worm-like micelles depending on the preparation method.	copolymer	13-22	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	0-3
25690041-4	2015	The aim of this study was (1) to develop a new method to test the antibacterial efficacy of implant surfaces by direct surface contact and (2) to elucidate whether an innovative antimicrobial copolymer coating of 4-vinyl-N-hexylpyridinium bromide and dimethyl(2-methacryloyloxyethyl) phosphonate (VP:DMMEP 30:70) on titanium is able to reduce the attachment of bacteria prevalent in peri-implant infections.	copolymer	192-201	perilipin 1	Homo sapiens	383-387
25224297-10	2015	The supramolecular hydrogel obtained by mixing 10.54% (w/v) gamma-CD and 2.5% (w/v) copolymer had an excellent syringeability.	copolymer	84-93	tryptophanyl-tRNA synthetase 1	Homo sapiens	60-74
25401377-2	2015	METHODS: A copolymer consisting of a single-chain variable fragment targeted to human CD44 variant 6 (scFv(CD44v6)) functional group conjugated to polyethylene glycol-poly-L-lysine was synthesized and assembled into micelles encapsulating the siRNAs.	copolymer	11-20	immunglobulin heavy chain variable region	Homo sapiens	102-106
25581352-1	2015	In the previous study, we have synthesized an amphiphilic copolymer of nanostructure-forming material and P-glycoprotein (P-gp) inhibitor, lysine-linked ditocopherol polyethylene glycol 2000 succinate (PLV2K).	copolymer	58-67	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	106-120
25581352-1	2015	In the previous study, we have synthesized an amphiphilic copolymer of nanostructure-forming material and P-glycoprotein (P-gp) inhibitor, lysine-linked ditocopherol polyethylene glycol 2000 succinate (PLV2K).	copolymer	58-67	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	122-126
25145336-0	2015	Interaction studies between indomethacin nanocrystals and PEO/PPO copolymer stabilizers.	copolymer	66-75	protoporphyrinogen oxidase	Homo sapiens	62-65
25553689-2	2015	Mucin was extracted from the African giant snail and in combination with PEG was used to produce a copolymer matrix base, which was mixed with the model drugs using wet granulation method.	copolymer	99-108	LOC100508689	Homo sapiens	0-5
24934663-8	2015	A combination of rifampin and clarithromycin released from the polymer film provided >99.9% kill of an MRSA inoculate for up to 72 h. CONCLUSION: Results showed that combining multiple drugs in copolymer films with unique surface properties, initial hydrophilicity and increase in roughness, can be an effective way to prevent biofilm formation.	copolymer	197-206	solute carrier family 9 member A6	Homo sapiens	106-110
25621190-1	2014	A N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-CXCR4 antagonist (BKT140) conjugate (P-BKT140) was developed and its biological activities were tested.	copolymer	43-52	C-X-C motif chemokine receptor 4	Homo sapiens	53-58
26566467-5	2015	The number average molecular weight of the block copolymer was found to vary from 7511 to 21,270 as determined by GPC and 1HNMR studies.	copolymer	49-58	glycophorin C (Gerbich blood group)	Homo sapiens	114-117
25403150-3	2014	A potentiometric Pb(II) sensor was fabricated on the basis of the copolymer microparticles as a crucial solid ionophore component within plasticized PVC.	copolymer	66-75	submaxillary gland androgen regulated protein 3B	Homo sapiens	17-23
26447596-2	2015	Through grafting RGDS peptide onto the functionalized copolymer surface, the presented approach enables to prepare PLA surfaces with random and clustered spatial distribution of adhesive motifs.	copolymer	54-63	ral guanine nucleotide dissociation stimulator	Homo sapiens	17-21
25308862-6	2014	The degree of stretching of the tethered copolymer chains gradually grows with the increase of aPA or aPB, while the degree of stretching of solvophobic block B decreases when the morphologies change from spherical to disk-like micelles and further to rod-like micelles.	copolymer	41-50	glutamyl aminopeptidase	Homo sapiens	95-98
25308862-6	2014	The degree of stretching of the tethered copolymer chains gradually grows with the increase of aPA or aPB, while the degree of stretching of solvophobic block B decreases when the morphologies change from spherical to disk-like micelles and further to rod-like micelles.	copolymer	41-50	arginyl aminopeptidase	Homo sapiens	102-105
25264579-10	2014	The presence of nitrogen atoms at the surface of these copolymer latex particles was confirmed via X-ray photoelectron spectroscopy studies; these secondary amine groups allow covalent cross-linking via PPG-TDI when adsorbed at the surface of n-dodecane droplets at TBAEMA comonomer contents as low as 40 mol %.	copolymer	55-64	serglycin	Homo sapiens	203-206
25491862-6	2014	It is shown that the copolymer with 60 wt.% PEG side chains of 750 g/mol, where both PEG and PCOE form continuous morphology, is optimal to reduce the adsorption of both the bovine serum albumin (BSA) and platelet.	copolymer	21-30	albumin	Homo sapiens	181-194
25787203-4	2014	The complexation was studied in water as well as in vesicular medium of polyethylene glycol (PEG) and a block copolymer, PPG-PEG-PPG.	copolymer	110-119	serglycin	Homo sapiens	121-124
25787203-5	2014	The binding constants (k) of Zn-sulfanilamide complex were determined in water, PEG, and PPG-PEG-PPG block copolymer media.	copolymer	107-116	serglycin	Homo sapiens	89-92
25787203-5	2014	The binding constants (k) of Zn-sulfanilamide complex were determined in water, PEG, and PPG-PEG-PPG block copolymer media.	copolymer	107-116	serglycin	Homo sapiens	97-100
25311490-3	2014	A Thermo Gravimetric Analysis-Mass Spectrometry (TGA-GC-MS) method was optimised, validated and successfully applied to investigate the thermal behavior of ultrathin poly(styrene-r-methylmethacrylate) random copolymer layers P(S-r-MMA) grafted to a silicon wafer surface.	copolymer	208-217	T-box transcription factor 1	Homo sapiens	49-52
25329156-0	2014	Conformational antibody binding to a native, cell-free expressed GPCR in block copolymer membranes.	copolymer	79-88	vomeronasal 1 receptor 17 pseudogene	Homo sapiens	65-69
25364250-0	2014	Self-assembled micelles based on pH-sensitive PAE-g-MPEG-cholesterol block copolymer for anticancer drug delivery.	copolymer	75-84	progestagen associated endometrial protein	Homo sapiens	46-51
24789451-1	2014	PURPOSE: Our objective was to synthesize LHRH-conjugated amphiphilic copolymer for micellar delivery of CBDIV17, a novel antiandrogen for treating prostate cancer.	copolymer	69-78	gonadotropin releasing hormone 1	Homo sapiens	41-45
25118045-4	2014	Formation of the Co(i) species of the B12 complex in the copolymer was confirmed by the UV-vis spectral change in [C4mim][NTf2] containing a sacrificial reductant (triethanolamine) under irradiation with visible light.	copolymer	57-66	nuclear transport factor 2	Homo sapiens	122-126
25152419-0	2014	Co-immobilized glucose oxidase and beta-galactosidase on bovine serum albumin coated allyl glycidyl ether (AGE)-ethylene glycol dimethacrylate (EGDM) copolymer as a biosensor for lactose determination in milk.	copolymer	150-159	galactosidase beta 1	Homo sapiens	35-53
25118045-3	2014	The Ru(ii) trisbipyridine photosensitizer in the copolymer showed an enhanced emission compared to that of the monomer in the ionic liquid, 1-butyl-4-methylimidazolium bis(trifluoromethanesulfonyl)amide ([C4mim][NTf2]).	copolymer	49-58	nuclear transport factor 2	Homo sapiens	212-216
25137434-1	2014	This report describes the synthesis of amphiphilic copolymers (ABC-1 and ABC-2) composed of a hydrophilic poly(ethylene glycol) (PEG) block, a central poly(acrylic acid) (PAA) block, and a random copolymer of heptadecafluorodecyl methacrylate (HDFMA) and methyl methacrylate (MMA) forming the hydrophobic block, which are used to form nanodroplets for ultrasound-mediated cell ablation.	copolymer	51-60	ATP binding cassette subfamily A member 1	Homo sapiens	63-68
25137434-1	2014	This report describes the synthesis of amphiphilic copolymers (ABC-1 and ABC-2) composed of a hydrophilic poly(ethylene glycol) (PEG) block, a central poly(acrylic acid) (PAA) block, and a random copolymer of heptadecafluorodecyl methacrylate (HDFMA) and methyl methacrylate (MMA) forming the hydrophobic block, which are used to form nanodroplets for ultrasound-mediated cell ablation.	copolymer	51-60	ATP binding cassette subfamily A member 2	Homo sapiens	73-78
24614283-11	2014	HPMA copolymer-SQ-Cy5 exhibits preferable body distribution and drug release compared with the free drug and probe when administered to cathepsin B-overexpressing 4T1 murine mammary adenocarcinoma-bearing mice.	copolymer	5-14	cathepsin B	Mus musculus	136-147
24992665-0	2014	High specific detection of osteopontin using a three-dimensional copolymer layer support based on electrochemical impedance spectroscopy.	copolymer	65-74	secreted phosphoprotein 1	Homo sapiens	27-38
25042406-2	2014	This copolymer can self-aggregate into nanoparticles via electrostatic attraction between ammonium cation and sulfo-anion of PSBMA and successfully encapsulate anticancer drug, curcumin (CUR), with highest loading content of 2.6% in the P(SBMA-co-DPA) nanoparticles.	copolymer	5-14	androgen receptor	Homo sapiens	126-130
25216338-1	2014	Graft copolymer composed hyaluronic acid (HA) and poly(D,L-lactide-co-glycolide) (PLGA) (HAgLG) was synthesized for antitumor targeting via CD44 receptor of tumor cells.	copolymer	6-15	CD44 molecule (Indian blood group)	Homo sapiens	140-144
25023878-5	2014	The GPC data showed that the copolymer obtained from single-step eROP was similar to the end product obtained from the traditional multistep synthesis method.	copolymer	29-38	glycophorin C (Gerbich blood group)	Homo sapiens	4-7
24856106-4	2014	We transferred these benefits to the polyurethane block copolymer Elast-Eon E2A through a specific combination of surface plasma modifications and coating with human tropoelastin.	copolymer	56-65	elastin	Homo sapiens	166-178
24945939-3	2014	We prepared a bioactive coil coated with poly(d,l-lactide)-7co-(1,3-trimethylene carbonate) (P(DLLA-co-TMC)), a novel copolymer for controlling the release of vascular endothelial growth factor (VEGF).	copolymer	118-127	vascular endothelial growth factor A	Rattus norvegicus	159-193
24945939-3	2014	We prepared a bioactive coil coated with poly(d,l-lactide)-7co-(1,3-trimethylene carbonate) (P(DLLA-co-TMC)), a novel copolymer for controlling the release of vascular endothelial growth factor (VEGF).	copolymer	118-127	vascular endothelial growth factor A	Rattus norvegicus	195-199
24924945-2	2014	In an attempt to overcome the failed therapeutic impact of currently available antioxidants in cardiovascular disease, we developed a nanomedicine-based delivery system for the O2(-)-scavenging enzyme copper/zinc superoxide dismutase (CuZnSOD), in which CuZnSOD protein is electrostatically bound to a poly-l-lysine (PLL50)-polyethylene glycol (PEG) block copolymer to form a CuZnSOD nanozyme.	copolymer	356-365	superoxide dismutase 1, soluble	Mus musculus	235-242
24945908-6	2014	Triggering the phase transition of the ELP-block resulted in the formation of an amphiphilic block copolymer, which self-assembled into micelles.	copolymer	99-108	nuclear receptor subfamily 5 group A member 1	Homo sapiens	39-42
24758594-4	2014	In the present study, we present the application of a new methodology for the extraction and purification of ABC transporters without the use of detergent, instead, using a copolymer, SMA (polystyrene-co-maleic acid).	copolymer	173-182	survival of motor neuron 1, telomeric	Homo sapiens	184-187
24945908-7	2014	This is the first example of an ELP-containing hybrid block copolymer in which PEG as the hydrophilic corona-forming domain is combined with a stimulus-responsive ELP-block.	copolymer	60-69	nuclear receptor subfamily 5 group A member 1	Homo sapiens	32-35
24945908-7	2014	This is the first example of an ELP-containing hybrid block copolymer in which PEG as the hydrophilic corona-forming domain is combined with a stimulus-responsive ELP-block.	copolymer	60-69	nuclear receptor subfamily 5 group A member 1	Homo sapiens	163-166
24884872-2	2014	Here, we demonstrate a targeting mechanism that uses a thermoresponsive copolymer to mask a peptide ligand that binds a widely distributed receptor (integrin beta1) on the surface of silica core-gold shell nanoparticles.	copolymer	72-81	integrin subunit beta 1	Homo sapiens	149-163
24856087-1	2014	In this study, for the first time, a biodegradable poly(L-lactide-co-epsilon-caprolactone), PLC 67:33 copolymer was developed for use as temporary scaffolds in reconstructive nerve surgery.	copolymer	102-111	heparan sulfate proteoglycan 2	Homo sapiens	92-95
24874300-5	2014	Specifically, the synergistic effect of temperature and pH was observed, and the hydrogen bonding between PDEA and PMAA components in the copolymer played a key role for this.	copolymer	138-147	phosphodiesterase 6A	Homo sapiens	106-110
24237263-3	2014	We demonstrated earlier that packaging of catalase into a polyion complex micelle ("nanozyme") with a synthetic polyelectrolyte block copolymer protected the enzyme against degradation in macrophages and improved therapeutic outcomes.	copolymer	134-143	catalase	Mus musculus	42-50
24576804-2	2014	To co-deliver hydrophobic drug and functional gene efficiently into tumor cells, a star-shaped copolymer (PP-PLLD-Arg) with a photochemical internalization effect consisting of a porphyrin (PP) core and arginine-functionalized poly(L-lysine) dendron (PLLD-Arg) arms has been designed, and used to co-deliver docetaxel (DOC) and MMP-9 shRNA plasmid for nasopharyngeal cancer therapy.	copolymer	95-104	matrix metallopeptidase 9	Homo sapiens	328-333
24638848-0	2014	Electrochemically fabricated polypyrrole and MoS(x) copolymer films as a highly active hydrogen evolution electrocatalyst.	copolymer	52-61	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	45-48
24708538-0	2014	Distinct adsorption configurations and self-assembly characteristics of fibrinogen on chemically uniform and alternating surfaces including block copolymer nanodomains.	copolymer	146-155	fibrinogen beta chain	Homo sapiens	72-82
24708538-5	2014	By exploiting block copolymer nanodomains whose repeat distance is commensurate with the length of the individual protein, we determine that fibrinogen exhibits a more neutral tendency for interaction with both polystyrene and poly(methyl methacrylate) blocks relative to the case of common globular proteins.	copolymer	20-29	fibrinogen beta chain	Homo sapiens	141-151
24628090-1	2014	Brownian dynamics simulation is employed to examine the structure changes of complexes composed of a hydrophobic nanoparticle and a multiblock copolymer molecule (MCP).	copolymer	143-152	CD46 molecule	Homo sapiens	163-166
24589473-3	2014	The produced grafted copolymer was characterized by FTIR, TGA, surface area and elemental analysis.	copolymer	21-30	T-box transcription factor 1	Homo sapiens	58-61
24981025-1	2014	BACKGROUND: In the present study, a well-defined glucose and guanidine based copolymer, galactosylated 2-hydroxypropyl methacrylamide-s-3-guanidinopropyl methacrylamide (HPMA-s-GPMA) abbreviated as GGH was prepared and self-assembled with small hairpin RNA (shRNA) to inhibit human telomerase reverse transcriptase (hTERT) gene expression in vitro to develop a shRNA carrier.	copolymer	77-86	gamma-glutamyl hydrolase	Homo sapiens	198-201
24981025-1	2014	BACKGROUND: In the present study, a well-defined glucose and guanidine based copolymer, galactosylated 2-hydroxypropyl methacrylamide-s-3-guanidinopropyl methacrylamide (HPMA-s-GPMA) abbreviated as GGH was prepared and self-assembled with small hairpin RNA (shRNA) to inhibit human telomerase reverse transcriptase (hTERT) gene expression in vitro to develop a shRNA carrier.	copolymer	77-86	telomerase reverse transcriptase	Homo sapiens	282-314
24981025-1	2014	BACKGROUND: In the present study, a well-defined glucose and guanidine based copolymer, galactosylated 2-hydroxypropyl methacrylamide-s-3-guanidinopropyl methacrylamide (HPMA-s-GPMA) abbreviated as GGH was prepared and self-assembled with small hairpin RNA (shRNA) to inhibit human telomerase reverse transcriptase (hTERT) gene expression in vitro to develop a shRNA carrier.	copolymer	77-86	telomerase reverse transcriptase	Homo sapiens	316-321
24552290-1	2014	Thermoresponsive anionic copolymer brushes, poly(N-isopropylacrylamide-co-acrylic acid-co-tert-butylacrylamide) [P(IPAAm-co-AAc-co-tBAAm)], were grafted onto a monolithic silica rod column through surface-initiated atom-transfer radical polymerization (ATRP) to prepare an effective thermoresponsive anionic chromatography matrix.	copolymer	25-34	glycine-N-acyltransferase	Homo sapiens	124-127
24075972-0	2014	N-Acetylglucosamine-conjugated block copolymer consisting of poly(ethylene oxide) and cationic polyaspartamide as a gene carrier for targeting vimentin-expressing cells.	copolymer	37-46	vimentin	Homo sapiens	143-151
24508089-3	2014	The synthesized graft copolymer (Ag-g-PAM) has been investigated (in vitro) for controlled and colon targeted release of 5-amino salicylic acid (5-ASA).	copolymer	22-31	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	38-41
24460175-7	2014	The controlled release of insulin from the hydrogel devices was demonstrated by degradation of the copolymer, which is modulated via the 2,2"-dithiodiethanol content in the poly(ether-urethane)s.	copolymer	99-108	insulin	Homo sapiens	26-33
24449609-1	2014	Allyl glycidyl ether (AGE)-ethylene glycol dimethacrylate (EGDM) copolymer with 25% crosslink density (AGE-25) shows excellent bovine serum albumin (BSA) adsorption (up to 16% (w/w)) at pH 8.0 and the adsorbed BSA is strongly bound.	copolymer	65-74	albumin	Homo sapiens	134-147
24745277-0	2014	Dissipative particle dynamics simulation on paclitaxel loaded PEO-PPO-PEO block copolymer micelles.	copolymer	80-89	protoporphyrinogen oxidase	Homo sapiens	66-69
23943596-2	2014	First, the block copolymer poly(benzyl L-aspartate)-block-poly(ethylene glycol) (PBLA-b-PEG) is synthesized via ring-opening polymerization of beta-benzyl L-aspartate-N-carboxyanhydride (BLA-NCA) with alpha-methoxy-omega-aminopoly(ethylene glycol) (mPEG-NH2 ) as a macroinitiator.	copolymer	17-26	CEA cell adhesion molecule 4	Homo sapiens	191-194
24075972-7	2014	This study reveals that GlcNAc-coupled biocompatible block copolymer can specifically deliver gene to vimentin-expressing cells.	copolymer	59-68	vimentin	Homo sapiens	102-110
24529391-2	2014	Here, we present a simple but multifunctional micellar platform constructed by a matrix metalloproteinase 2 (MMP2)-sensitive copolymer (PEG-pp-PEI-PE) via self-assembly for tumor-targeted siRNA and drug co-delivery.	copolymer	125-134	matrix metallopeptidase 2	Homo sapiens	81-107
24529391-2	2014	Here, we present a simple but multifunctional micellar platform constructed by a matrix metalloproteinase 2 (MMP2)-sensitive copolymer (PEG-pp-PEI-PE) via self-assembly for tumor-targeted siRNA and drug co-delivery.	copolymer	125-134	matrix metallopeptidase 2	Homo sapiens	109-113
24338855-2	2014	Amphiphilic random copolymer poly(methyl methacrylate-co-methacrylic acid) (P(MMA-co-MAA)) was micellizated via neutralization in alkaline aqueous solution.	copolymer	19-28	MAA	Homo sapiens	85-88
23564487-2	2014	We have engineered a system for inducing self-assembly of model H35 rat hepatoma spheroids using a copolymer comprised of biocompatible elastin-like polypeptide (ELP) chemically conjugated to positively charged polyethyleneimine (PEI).	copolymer	99-108	diazepam binding inhibitor-like 5	Rattus norvegicus	136-160
23564487-2	2014	We have engineered a system for inducing self-assembly of model H35 rat hepatoma spheroids using a copolymer comprised of biocompatible elastin-like polypeptide (ELP) chemically conjugated to positively charged polyethyleneimine (PEI).	copolymer	99-108	diazepam binding inhibitor-like 5	Rattus norvegicus	162-165
24184534-4	2014	The multiblock copolymer micelles had lower critical micelle concentration than the linear counterpart, TEM size from 100 to 120 nm and the hydrodynamic diameters below 150 nm.	copolymer	15-24	MFT2	Homo sapiens	104-107
24075972-2	2014	Here, we synthesized a biocompatible block copolymer (abbreviated as PASPG) which consists of cationic poly[(aspartamide)(spermine)] for complexation with DNA and enhancing transfection efficiency due to buffering ability of spermine, poly(ethylene oxide)(PEO) for stability after systemic administration of the gene and N-acetylglucosamine (GlcNAc) as a specific ligand to target vimentin-expressing cells.	copolymer	43-52	vimentin	Homo sapiens	381-389
25671173-5	2014	Linear-dendritic copolymer was prepared in the presence of DCC in pyridine.	copolymer	17-26	DCC netrin 1 receptor	Homo sapiens	59-62
24075405-2	2013	For this purpose we used targeted polyplexes based on PEI-PEG-MC1SP block-copolymer containing MC1SP-peptide, a ligand specific for melanocortin receptor-1 (MC1R) overexpressed on melanoma cells.	copolymer	74-83	melanocortin 1 receptor	Mus musculus	132-155
24038924-4	2014	HPMA copolymer conjugates containing gemcitabine, a targeting ligand for HER2 receptors overexpressed in some pancreatic cancers, and an (111) In(3+) chelating agent are synthesized, characterized, and evaluated in vitro for their potential use as an IGDD system for pancreatic tumors.	copolymer	5-14	erb-b2 receptor tyrosine kinase 2	Homo sapiens	73-77
24346086-2	2014	In the present study, we synthesized a ternary copolymer mPEG-b-PLL-g-(ss-lPEI), denoted as PLI, by introducing disulfide bond linkages to graft low molecular weight linear polyethylenimine (lPEI) to the block copolymer of poly(L-lysine) (PLL) and poly(ethylene glycol) (PEG) for siRNA delivery.	copolymer	47-56	serpin family F member 2	Homo sapiens	92-95
24346086-2	2014	In the present study, we synthesized a ternary copolymer mPEG-b-PLL-g-(ss-lPEI), denoted as PLI, by introducing disulfide bond linkages to graft low molecular weight linear polyethylenimine (lPEI) to the block copolymer of poly(L-lysine) (PLL) and poly(ethylene glycol) (PEG) for siRNA delivery.	copolymer	210-219	serpin family F member 2	Homo sapiens	92-95
24256424-4	2013	The mobility of the copolymer microgel whose COOH groups are fully ionized agreed with that of PAAc when its ionization degree (alpha(n)) is close to the mole fraction (f(AAc)) of the AAc unit in the copolymer gel.	copolymer	20-29	glycine-N-acyltransferase	Homo sapiens	171-174
24256424-4	2013	The mobility of the copolymer microgel whose COOH groups are fully ionized agreed with that of PAAc when its ionization degree (alpha(n)) is close to the mole fraction (f(AAc)) of the AAc unit in the copolymer gel.	copolymer	200-209	glycine-N-acyltransferase	Homo sapiens	96-99
24256424-5	2013	There was good agreement between the mobility values of the copolymer microgel and the linear NIPA/AAc copolymer when their AAc contents are very close to each other.	copolymer	60-69	glycine-N-acyltransferase	Homo sapiens	124-127
24075405-2	2013	For this purpose we used targeted polyplexes based on PEI-PEG-MC1SP block-copolymer containing MC1SP-peptide, a ligand specific for melanocortin receptor-1 (MC1R) overexpressed on melanoma cells.	copolymer	74-83	melanocortin 1 receptor	Mus musculus	157-161
23793991-1	2013	PURPOSE: Our objective was to develop novel nanocarriers (protected graft copolymer, PGC) that improve the stability of heparin binding EGF (HBEGF) and gastrin and then to use PGC-formulated HBEGF (PGC-HBEGF) and Omeprazole (+/- PGC-gastrin) for normalizing fasting blood glucose (FBG) and improving islet function in diabetic mice.	copolymer	74-83	epidermal growth factor	Mus musculus	136-139
32261065-0	2013	Biodegradable micelles from a hyaluronan-poly(epsilon-caprolactone) graft copolymer as nanocarriers for fibroblast growth factor 1.	copolymer	74-83	fibroblast growth factor 1	Rattus norvegicus	104-130
32261065-2	2013	The copolymer formed micelles with a size of ~60 nm in aqueous solution over a critical concentration of ~4 mug mL-1.	copolymer	4-13	L1 cell adhesion molecule	Mus musculus	112-116
24055698-8	2013	Drug release studies showed that the increasing content of MAA in the copolymer enhances release in SIF to design and improve insulin release behavior from these carriers.	copolymer	70-79	insulin	Homo sapiens	126-133
23629851-6	2013	Scanning electron microscope imaging of hASC show expected spindle shaped morphology when adhered to copolymer.	copolymer	101-110	PYD and CARD domain containing	Homo sapiens	40-44
24236402-1	2013	This study compares the damping behavior of boron nitride nanotubes (BNNTs) and carbon nanotubes (CNTs) as reinforcement in PLC, a biodegradable copolymer.	copolymer	145-154	heparan sulfate proteoglycan 2	Homo sapiens	124-127
24127854-3	2013	Specifically, the copolymer-lipid bilayer consists of natural phospholipids (soy phosphatidylcholine, SPC) and the poly(N-isopropylacrylamide-methacrylic acid-octadecyl acrylate) (p(NIPAM-MAA-ODA)) copolymer.	copolymer	18-27	proline rich protein gene cluster	Homo sapiens	102-105
24066900-0	2013	Active targeting of block copolymer micelles with trastuzumab Fab fragments and nuclear localization signal leads to increased tumor uptake and nuclear localization in HER2-overexpressing xenografts.	copolymer	26-35	erb-b2 receptor tyrosine kinase 2	Mus musculus	168-172
24066900-4	2013	The current study aims to elucidate the in vivo fate of 31-nm-sized block copolymer micelles (BCMs) targeted to the nucleus of HER2-overexpressing breast cancer cells.	copolymer	74-83	erb-b2 receptor tyrosine kinase 2	Mus musculus	127-131
23793991-1	2013	PURPOSE: Our objective was to develop novel nanocarriers (protected graft copolymer, PGC) that improve the stability of heparin binding EGF (HBEGF) and gastrin and then to use PGC-formulated HBEGF (PGC-HBEGF) and Omeprazole (+/- PGC-gastrin) for normalizing fasting blood glucose (FBG) and improving islet function in diabetic mice.	copolymer	74-83	gastrin	Mus musculus	233-240
23793991-1	2013	PURPOSE: Our objective was to develop novel nanocarriers (protected graft copolymer, PGC) that improve the stability of heparin binding EGF (HBEGF) and gastrin and then to use PGC-formulated HBEGF (PGC-HBEGF) and Omeprazole (+/- PGC-gastrin) for normalizing fasting blood glucose (FBG) and improving islet function in diabetic mice.	copolymer	74-83	heparin-binding EGF-like growth factor	Mus musculus	141-146
23793991-1	2013	PURPOSE: Our objective was to develop novel nanocarriers (protected graft copolymer, PGC) that improve the stability of heparin binding EGF (HBEGF) and gastrin and then to use PGC-formulated HBEGF (PGC-HBEGF) and Omeprazole (+/- PGC-gastrin) for normalizing fasting blood glucose (FBG) and improving islet function in diabetic mice.	copolymer	74-83	gastrin	Mus musculus	152-159
23953650-8	2013	GPC as well as DSC analysis confirmed the formation of block copolymer.	copolymer	61-70	glycophorin C (Gerbich blood group)	Homo sapiens	0-3
23880471-3	2013	The TMN complexes were prepared by simply mixing the negatively charged SPL copolymer and the positively charged etanercept via electrostatic interaction at 4  C below the polymer"s clouding temperature (CT), and the resulting complex demonstrated significantly improved salt and serum stability with increased hydrophobic interactions at temperatures (physiological condition, 37.5  C) above the CT. An in vitro study of the bioactivity of etanercept indicated that the TMN complex improves the long-term stability of etanercept in an aqueous environment because of the exposure of the functional active site and the molecular chaperone-like effect of the hydrophobic copolymer.	copolymer	76-85	sphingosine-1-phosphate lyase 1	Rattus norvegicus	72-75
25619143-1	2013	In this work we report on the synthesis and self-assembly of a thermo-sensitive block copolymer system of n-octadecyl-poly(ethylene glycol)-block-poly(N-isopropylacrylamide), abbreviated as C18-PEGn-b-PNIPAAMm.	copolymer	86-95	Bardet-Biedl syndrome 9	Homo sapiens	190-193
23987367-2	2013	The copolymer matrix used to obtain the magnetic nanocomposites was synthesized by grafting reaction of carboxymethyl starch (CMS) with D,L-lactic acid (DLLA), in the presence of Sn octanoate [Sn(Oct)2] as catalyst.	copolymer	4-13	POU class 2 homeobox 2	Homo sapiens	196-201
23732799-2	2013	The graft copolymer was developed by grafting PAM chains onto HPMC backbone using potassium persulphate as initiator.	copolymer	10-19	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	46-49
23939290-2	2013	PyDPP was polymerized with bithiophene (BT) to afford a low band-gap copolymer (PBTPyDPP) which was used as an electron donor of the active layer in polymer solar cells.	copolymer	69-78	dentin sialophosphoprotein	Homo sapiens	80-88
24245114-2	2013	The structure and molecular weight of the copolymer were confirmed by 1H NMR, FT-IR and GPC, respectively.	copolymer	42-51	glycophorin C (Gerbich blood group)	Homo sapiens	78-91
23830461-0	2013	Cadmium detection by a thermally responsive elastin copolymer with metal-binding functionality.	copolymer	52-61	elastin	Homo sapiens	44-51
23809862-6	2013	The block copolymer with block ratio of almost 1:1 and higher molecular weight than that of previous PMMA-b-PS was sulfonated with acetyl sulfate, and the sulfonation was confirmed by FTIR, (1)H NMR, and TGA.	copolymer	10-19	T-box transcription factor 1	Homo sapiens	204-207
23770222-5	2013	In our study, 10 mol.% of cyclic ketals were deprotected and the ketone-containing copolymer was designated as ECT2-CO.	copolymer	83-92	epithelial cell transforming 2	Homo sapiens	111-115
23902563-8	2013	TGA, FT-IR, and XRD results indicated that the block copolymer used for synthesis remained on the HAp particle surface.	copolymer	53-62	T-box transcription factor 1	Homo sapiens	0-3
23802223-1	2013	A matrix metalloproteinase-cleavable peptide-linked block copolymer was fabricated and utilized to construct PEG-sheddable polyplex micelles as smart gene delivery vectors, which were demonstrated to exhibit higher cellular uptake, improved endosomal escape, and high-efficiency gene transfection in the presence of matrix metalloproteinase-2.	copolymer	58-67	matrix metallopeptidase 2	Homo sapiens	316-342
24693625-12	2013	Between-treatment group comparisons for change from baseline values showed that the improvement in number of bleeding sites from baseline for the SnF2 group was 49% greater versus that of the triclosan/copolymer group (P < 0.001), and the GBI and MGI improvements from baseline for the SnF2 group were 48% and 37%, greater, respectively, relative to the triclosan/copolymer group (P < 0.001).	copolymer	367-376	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	146-150
23815156-3	2013	Herein, a novel copolymer, D-alpha-tocopheryl polyethylene glycol 1000-block-poly(beta-amino ester) (TPGS-b-PBAE, TP), was synthesized for overcoming multidrug resistance by the synergistic effect of the pH-sensitive behavior of PBAE and P-gp inhibiting activity of TPGS.	copolymer	16-25	ATP binding cassette subfamily B member 1	Homo sapiens	238-242
23694904-2	2013	The star-shaped block copolymer CA-PLGA-b-TPGS of three branch arms was synthesized through the core-first approach and characterized by (1)H NMR, GPC and TGA.	copolymer	22-31	glycophorin C (Gerbich blood group)	Homo sapiens	147-150
23694904-2	2013	The star-shaped block copolymer CA-PLGA-b-TPGS of three branch arms was synthesized through the core-first approach and characterized by (1)H NMR, GPC and TGA.	copolymer	22-31	T-box transcription factor 1	Homo sapiens	155-158
23936062-3	2013	In this paper, we synthesized a gelatinase-responsive copolymer (mPEG-PCL) by inserting a gelatinase cleavable peptide (PVGLIG) between mPEG and PCL blocks of mPEG-PCL for anticancer drug delivery to make use of MMP2/9 as an intelligent target for drug delivery.	copolymer	54-63	matrix metallopeptidase 2	Homo sapiens	212-218
23913603-2	2013	We evaluated clinical performance of paclitaxel-eluting stents coated with a new bioactive polymer system (P-5) based on a copolymer of an acrylic derivative of triflusal in patients with coronary artery disease.	copolymer	123-132	solute carrier family 10 member 5	Homo sapiens	107-110
23255175-5	2013	The copolymer at 9:1 ratio of NIPAM to VP resulted in the formation of nanoparticle-based gel (NG1) at 30 C; however, at 70 C, a microgel (MG1) was formed.	copolymer	4-13	interleukin 19	Homo sapiens	95-98
23702850-2	2013	The copolymer microparticles containing many ligating functional groups including amino, imino and sulfonic groups were synthesized by a chemical oxidative copolymerization of m-phenylenediamine (mPD) and p-sulfonic-m-phenylenediamine (SPD) in pure water.	copolymer	4-13	mevalonate (diphospho) decarboxylase	Mus musculus	196-199
23466536-0	2013	Lysozyme immobilization via adsorption process using sulphonic acid functionalized silane grafted copolymer.	copolymer	98-107	lysozyme	Homo sapiens	0-8
23648038-4	2013	The graft copolymer based flocculants have been developed under optimum conditions and characterized using viscometry, (13)C NMR, SEM, TGA, rheological characteristics, determination of hydrodynamic radius and CHN analysis.	copolymer	10-19	T-box transcription factor 1	Homo sapiens	135-138
23721569-8	2013	RESULTS: FTIR, XRD, TGA and DSC studies confirmed the formation of new copolymer.	copolymer	71-80	T-box transcription factor 1	Homo sapiens	20-23
23662624-1	2013	A series of pH-responsive random copolymer poly(l-glutamic acid-co-l-lysine) [P(Glu-co-Lys)] were synthesized through the ring-opening polymerization (ROP) of gamma-benzyl-l-glutamate N-carboxyanhydride (BLG-NCA) and 3-benzyloxycarbonyl-l-lysine N-carboxyanhydride (ZLys-NCA) and the subsequent deprotection.	copolymer	33-42	CEA cell adhesion molecule 6	Homo sapiens	208-211
23662624-1	2013	A series of pH-responsive random copolymer poly(l-glutamic acid-co-l-lysine) [P(Glu-co-Lys)] were synthesized through the ring-opening polymerization (ROP) of gamma-benzyl-l-glutamate N-carboxyanhydride (BLG-NCA) and 3-benzyloxycarbonyl-l-lysine N-carboxyanhydride (ZLys-NCA) and the subsequent deprotection.	copolymer	33-42	CEA cell adhesion molecule 6	Homo sapiens	271-274
23621358-2	2013	This latter was obtained by chemical reaction of alpha,beta-poly(N-2-hydroxyethyl) (2-aminoethylcarbamate)-dl-aspartamide (PHEA-EDA) with polylactic acid (PLA), and subsequent reaction with lactose, obtaining PHEA-EDA-PLA-GAL copolymer.	copolymer	226-235	ectodysplasin A	Homo sapiens	128-131
23613425-2	2013	In this study, Bcl-xL siRNA and doxorubicin (DOX) are encapsulated into designed methoxy-poly(ethylene glycol)-block-poly(D,L-lactic acid) (mPEG-b-PLA) block copolymer polymersomes (PSomes).	copolymer	158-167	BCL2 like 1	Homo sapiens	15-21
26909278-5	2013	OPG was administered in vivo by non-viral gene transfer using an amphiphilic non ionic block copolymer.	copolymer	93-102	TNF receptor superfamily member 11b	Homo sapiens	0-3
23422564-3	2013	Here, we describe the stabilization of bFGF by covalent conjugation with a heparin-mimicking polymer, a copolymer consisting of styrene sulfonate units and methyl methacrylate units bearing poly(ethylene glycol) side chains.	copolymer	104-113	fibroblast growth factor 2	Homo sapiens	39-43
23531592-3	2013	In this work, a water soluble copolymer flocculant, STC-g-PDMC (starch-graft-poly (2-methacryloyloxyethyl) trimethyl ammonium chloride) was synthesized through grafting a monomer, (2-methacryloyloxyethyl) trimethyl ammonium chloride (DMC), onto starch initiated by potassium persulphate.	copolymer	30-39	stanniocalcin 1	Homo sapiens	52-55
23305884-1	2013	A stable drug carrier has been prepared by covalently coating magnetic nanoparticles (MNPs) with PEO-PPO-PEO block copolymer Pluronic P85.	copolymer	115-124	protoporphyrinogen oxidase	Homo sapiens	101-104
23383965-0	2013	Photoresponsive retinal-modified silk-elastin copolymer.	copolymer	46-55	elastin	Homo sapiens	38-45
23396576-1	2013	A photo-, acid- and thermo-responsive nitrobenzene-based amphiphilic copolymer was synthesized and the corresponding multi-responsive behavior of the copolymer assemblies was revealed by TEM, DLS and AFM.	copolymer	69-78	MFT2	Homo sapiens	187-190
23396576-1	2013	A photo-, acid- and thermo-responsive nitrobenzene-based amphiphilic copolymer was synthesized and the corresponding multi-responsive behavior of the copolymer assemblies was revealed by TEM, DLS and AFM.	copolymer	150-159	MFT2	Homo sapiens	187-190
23626400-0	2013	Novel pentablock copolymer (PLA-PCL-PEG-PCL-PLA) based nanoparticles for controlled drug delivery: Effect of copolymer compositions on the crystallinity of copolymers and in vitro drug release profile from nanoparticles.	copolymer	17-26	PHD finger protein 1	Homo sapiens	32-35
23626400-0	2013	Novel pentablock copolymer (PLA-PCL-PEG-PCL-PLA) based nanoparticles for controlled drug delivery: Effect of copolymer compositions on the crystallinity of copolymers and in vitro drug release profile from nanoparticles.	copolymer	17-26	PHD finger protein 1	Homo sapiens	40-43
23261689-5	2013	The efficiency of this copolymer for biomolecule anchoring was investigated with biotin- and histidine- tagged glucose oxidases, biotin-tagged cholera toxin and a histidine-tagged thrombin aptamer.	copolymer	23-32	coagulation factor II, thrombin	Homo sapiens	180-188
28809208-2	2013	Firstly, a novel HRP enzyme-antibody copolymer (EV-p24 Ab2) was synthesized through an EnVision regent (EV, a dextrin amine skeleton anchoring more than 100 molecules of HRP and 15 molecules of anti IgG), then incubated in the secondary antibody of p24.	copolymer	37-46	transmembrane p24 trafficking protein 2	Homo sapiens	51-54
28809208-2	2013	Firstly, a novel HRP enzyme-antibody copolymer (EV-p24 Ab2) was synthesized through an EnVision regent (EV, a dextrin amine skeleton anchoring more than 100 molecules of HRP and 15 molecules of anti IgG), then incubated in the secondary antibody of p24.	copolymer	37-46	transmembrane p24 trafficking protein 2	Homo sapiens	249-252
28809208-3	2013	Secondly, the copolymer was immobilized on the gold nanocolloids (AuNPs) to fabricate a novel signal tag (AuNPs/EV-p24 Ab2).	copolymer	14-23	transmembrane p24 trafficking protein 2	Homo sapiens	115-118
23224976-0	2013	Protected graft copolymer excipient leads to a higher acute maximum tolerated dose and extends residence time of vasoactive intestinal Peptide significantly better than sterically stabilized micelles.	copolymer	16-25	vasoactive intestinal peptide	Homo sapiens	113-142
23224976-2	2013	METHODS: VIP was formulated using a micellar (Sterically Stabilized Micelles, SSM) and a polymer-based (Protected Graft Copolymer, PGC) nanocarrier at various loading percentages.	copolymer	120-129	vasoactive intestinal peptide	Homo sapiens	9-12
23089310-0	2013	Mechanism of inhibition of P-glycoprotein mediated efflux by Pluronic P123/F127 block copolymers: relationship between copolymer concentration and inhibitory activity.	copolymer	86-95	ATP binding cassette subfamily B member 1	Homo sapiens	27-41
23311773-5	2013	With real-time FTIR experiments, we show that the methyl deformation mode can act as a signature for the PPO microenvironment so as to trace the progressive copolymer self-association throughout the irradiation time.	copolymer	157-166	protoporphyrinogen oxidase	Homo sapiens	105-108
23175177-0	2013	Role of block copolymer-micelle nanocomposites in dye-bovine serum albumin binding: a combined experimental and molecular docking study.	copolymer	14-23	albumin	Homo sapiens	61-74
23627041-3	2013	During the preparation, amphiphilic copolymer MPEG-PCL was chosen to form the unique core-shell structure, and tacrolimus was loaded into the hydrophobic core due to its great hydrophobicity.	copolymer	36-45	polycystic kidney disease 2-like 1	Mus musculus	51-54
23627041-4	2013	After several relevant tests, MPEG-PCL (2000-2000) was selected to be the most suitable and safest copolymer for drug carrier.	copolymer	99-108	polycystic kidney disease 2-like 1	Mus musculus	35-38
23099248-4	2013	Glycerol and glucose interact favorably with water, and reduce the block copolymer critical micelle concentration (cmc) by dehydrating the PEO-PPO interface as well as changing the bulk solvent properties.	copolymer	73-82	protoporphyrinogen oxidase	Homo sapiens	143-146
23089594-0	2013	Surface-active copolymer formation stabilizes PEG droplets and bubbles in silicone foams.	copolymer	15-24	progestagen associated endometrial protein	Homo sapiens	46-49
23696703-8	2013	All the results suggested that amphiphilic copolymer (PGA-co-PCL)-b-TPGS2k could act as a potential biological material for nanoformulation in the treatment of lung cancer.	copolymer	43-52	tubulin polyglutamylase complex subunit 2	Homo sapiens	68-73
23909655-1	2013	This study describes the formation of highly efficient antiprotein adsorption random copolymer coating of poly(N,N-dimethylacrylamide-co-sulfobetaine methacrylate) (poly(DMA-co-SBMA)) on the fused-silica capillary inner wall.	copolymer	85-94	androgen receptor	Homo sapiens	177-181
23565690-7	2013	It was found that both platelet adhesion and fibrinogen adsorption decreased with increasing copolymer content in the blends and with decreasing PEO block size for a given copolymer content.	copolymer	93-102	fibrinogen beta chain	Homo sapiens	45-55
23565690-7	2013	It was found that both platelet adhesion and fibrinogen adsorption decreased with increasing copolymer content in the blends and with decreasing PEO block size for a given copolymer content.	copolymer	172-181	fibrinogen beta chain	Homo sapiens	45-55
23101937-2	2012	Interestingly, this protein-based block copolymer could be self-assembled via two mechanisms into two different, well-defined nanocapsules: (1) pH-induced assembly yielded 28 nm virus-like particles, and (2) ELP-induced assembly yielded 18 nm virus-like particles.	copolymer	40-49	nuclear receptor subfamily 5 group A member 1	Homo sapiens	208-211
23565868-5	2013	Antibacterial activity of copolymer increased with increasing of substituted alkyl chain length of QAM, and the sequence followed as 5%C10 < 5%C11   5%C12 < 5%C16   5%C18.	copolymer	26-35	chromosome 12 open reading frame 57	Homo sapiens	135-138
23565868-5	2013	Antibacterial activity of copolymer increased with increasing of substituted alkyl chain length of QAM, and the sequence followed as 5%C10 < 5%C11   5%C12 < 5%C16   5%C18.	copolymer	26-35	RNA polymerase III subunit K	Homo sapiens	146-149
23565868-5	2013	Antibacterial activity of copolymer increased with increasing of substituted alkyl chain length of QAM, and the sequence followed as 5%C10 < 5%C11   5%C12 < 5%C16   5%C18.	copolymer	26-35	Bardet-Biedl syndrome 9	Homo sapiens	173-176
23565868-6	2013	Copolymers containing C18 and C16 had the best inhibition effectiveness on both young biofilm and mature biofilm, copolymers containing C12 and C11 only had inhibition effectiveness on young biofilm and copolymer containing C10 had none inhibition effectiveness on neither young biofilm nor mature biofilm.	copolymer	114-123	RNA polymerase III subunit K	Homo sapiens	144-147
23565868-6	2013	Copolymers containing C18 and C16 had the best inhibition effectiveness on both young biofilm and mature biofilm, copolymers containing C12 and C11 only had inhibition effectiveness on young biofilm and copolymer containing C10 had none inhibition effectiveness on neither young biofilm nor mature biofilm.	copolymer	114-123	chromosome 12 open reading frame 57	Homo sapiens	224-227
23093022-7	2013	Surprisingly, the assembly of an ELP block copolymer (78 kD) into nanoparticles (R(h) = 37.5 nm) minimally influences pharmacokinetics or tumor accumulation compared to a free ELP of similar length (74 kD).	copolymer	43-52	nuclear receptor subfamily 5 group A member 1	Homo sapiens	33-36
23093022-7	2013	Surprisingly, the assembly of an ELP block copolymer (78 kD) into nanoparticles (R(h) = 37.5 nm) minimally influences pharmacokinetics or tumor accumulation compared to a free ELP of similar length (74 kD).	copolymer	43-52	nuclear receptor subfamily 5 group A member 1	Homo sapiens	176-179
23421205-6	2012	The cytotoxicity assay of blank nanoparticles indicated that polyketal copolymer (PK3) was biocompatible and suitable as drug vehicle, while PK3 nanoparticle encapsulating DOX or PTX could kill the cancer cells sufficiently and efficiently.	copolymer	71-80	pyruvate kinase M1/2	Homo sapiens	82-85
22820448-6	2012	The transfection efficacy of these polyplexes was significantly reduced compared to the PEI homopolymer, but was restored by the application of the corresponding degradable copolymer, which involved a redox triggerable PEG domain.	copolymer	173-182	progestagen associated endometrial protein	Homo sapiens	219-222
23083188-5	2012	In addition, we examine the effect of different parameters, such as grafting density (rho(g)), the bottom block length (N(A)), and the chain length of solvent (N(S)) on the solvent response of copolymer brushes.	copolymer	193-202	ras homolog family member G	Homo sapiens	86-92
22770799-1	2012	A star-shape copolymer of nanostructure-forming material, P-glycoprotein (P-gp) reversible inhibitor and anticancer enhancer, lysine-linked di-tocopherol polyethylene glycol 2000 succinate (PLV(2K)), was synthesized to overcome multidrug resistance (MDR) in cancer chemotherapy.	copolymer	13-22	ATP binding cassette subfamily B member 1	Homo sapiens	74-78
22770799-8	2012	In summary, PLV(2K) copolymer has striking functions such as uncompetitive P-gp ATPase reversible inhibitor and anticancer efficacy, and could be a promising nanocarrier in improving the chemotherapy of hydrophobic anticancer drugs.	copolymer	20-29	ATP binding cassette subfamily B member 1	Homo sapiens	75-79
22818981-7	2012	This block copolymer self-assembles into 300 nm-diameter particles with a protein tethering moiety for surface covalent conjugation of IL-1Ra protein.	copolymer	11-20	interleukin 1 receptor antagonist	Rattus norvegicus	135-141
22818981-8	2012	This copolymer particle system efficiently bound IL-1Ra and maintained protein bioactivity in vitro.	copolymer	5-14	interleukin 1 receptor antagonist	Rattus norvegicus	49-55
22902590-2	2012	A simple synthesis and purification procedure is established for chemically cross-linked polyion complexes of Cu/Zn superoxide dismutase (SOD1) or catalase with a cationic block copolymer, methoxy-poly(ethylene glycol)-block-poly(L-lysine hydrochloride) (PEG-pLL50).	copolymer	178-187	superoxide dismutase 1	Rattus norvegicus	138-142
22823574-1	2012	A series of supramolecular aggregates were prepared using a poly(propylene oxide)-poly(ethylene oxide)-poly(propylene oxide) (PPO-PEO-PPO) block copolymer and beta- or alpha-cyclodextrins (CD).	copolymer	145-154	protoporphyrinogen oxidase	Homo sapiens	126-129
23037204-4	2012	The addition of DVB also increases the volume expansion coefficient of the copolymer, resulting in an increased thermo-optic (TO) coefficient for the copolymer system.	copolymer	75-84	major histocompatibility complex, class II, DQ beta 3	Homo sapiens	16-19
22823574-1	2012	A series of supramolecular aggregates were prepared using a poly(propylene oxide)-poly(ethylene oxide)-poly(propylene oxide) (PPO-PEO-PPO) block copolymer and beta- or alpha-cyclodextrins (CD).	copolymer	145-154	protoporphyrinogen oxidase	Homo sapiens	134-137
22957431-3	2012	The purpose of this study was to use the novel copolymer (mPEG5k-PCL1.2k)1.4-g-PEl10k to prepare siRNA-loaded nanoparticles for siRNA delivery.	copolymer	47-56	PHD finger protein 1	Homo sapiens	65-69
22934765-6	2012	Pluronic F127 poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) PEO-PPO-PEO block copolymer known to be stimuli-responsive and show structure changes when subjected to external, temperature and magnetic signals.	copolymer	96-105	protoporphyrinogen oxidase	Homo sapiens	82-85
22677055-0	2012	Loess clay based copolymer for removing Pb(II) ions.	copolymer	17-26	submaxillary gland androgen regulated protein 3B	Homo sapiens	40-46
22736203-2	2012	In this study, we coated a bioresorbable FDA-approved poly-(epsilon-caprolactone)-scaffold for bone regeneration with a poly-(D,L-lactide) layer containing copolymer-protected gene vectors to locally provide bone morphogenetic protein-2 (BMP-2).	copolymer	156-165	bone morphogenetic protein 2	Mus musculus	208-236
22712750-5	2012	The best characterized APol to date, A8-35, is a random copolymer of acrylic acid, isopropylacrylamide, and octylacrylamide.	copolymer	56-65	apolipoprotein L1	Homo sapiens	23-27
22575779-10	2012	Experimental results were discussed and explained on the basis of two- and three-dimensional copolymer structure taking into account that PPO chains could be partially immersed in hexane and water.	copolymer	93-102	protoporphyrinogen oxidase	Homo sapiens	138-141
22694801-2	2012	In comparison to the NON copolymer, gelation of the PON terpolymer was achieved at a much lower concentration, with a much sharper sol-gel transition.	copolymer	25-34	paraoxonase 1	Homo sapiens	52-55
22560492-0	2012	ABC copolymer silicone surfactant templating for biomimetic silicification.	copolymer	4-13	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	0-3
24031933-10	2012	This is the first report on simultaneous production of copolymer of bacterial PHA and alpha-amylase from unhydrolysed corn starch and agro-industrial residues as substrates.	copolymer	55-64	alpha-amylase	Zea mays	86-99
22024195-10	2012	Pc 4 was delivered in block-copolymer micelles surface-modified with GE11 peptides targeting EGFR-overexpressing cancer cells.	copolymer	28-37	proprotein convertase subtilisin/kexin type 4	Homo sapiens	0-4
22736203-2	2012	In this study, we coated a bioresorbable FDA-approved poly-(epsilon-caprolactone)-scaffold for bone regeneration with a poly-(D,L-lactide) layer containing copolymer-protected gene vectors to locally provide bone morphogenetic protein-2 (BMP-2).	copolymer	156-165	bone morphogenetic protein 2	Mus musculus	238-243
22334508-2	2012	In the presence of the dyad, the 1:1 association of a disulfide-bridged myoglobin dimer (green) with streptavidin (gray) afforded a submicrometer-sized fibrous alternating copolymer.	copolymer	172-181	myoglobin	Homo sapiens	72-81
22277745-6	2012	The nonspecific adsorption of fibrinogen and lysozyme was measured as a function of the copolymer brush thickness using a surface plasmon resonance biosensor.	copolymer	88-97	fibrinogen beta chain	Homo sapiens	30-40
22277745-9	2012	The dual functional properties of TMA:CAA copolymers were demonstrated by conjugating fibrinogen to the copolymer brush over a range of brush thicknesses.	copolymer	42-51	fibrinogen beta chain	Homo sapiens	86-96
22425383-2	2012	The purpose of this work was to evaluate the effect of this ultrasound regimen on the cellular accumulation of paclitaxel (PTX) loaded in copolymer micellar of methoxy poly(ethylene glycol)-block-poly(D,L-lactide) (MePEG-b-PDLLA) in both drug-sensitive (MDCKII and MCF-7) and P-glycoprotein (Pgp)-expressing (MDCKII-MDR and NCI-ADR) cell lines.	copolymer	138-147	PGP	Canis lupus familiaris	276-290
22425383-2	2012	The purpose of this work was to evaluate the effect of this ultrasound regimen on the cellular accumulation of paclitaxel (PTX) loaded in copolymer micellar of methoxy poly(ethylene glycol)-block-poly(D,L-lactide) (MePEG-b-PDLLA) in both drug-sensitive (MDCKII and MCF-7) and P-glycoprotein (Pgp)-expressing (MDCKII-MDR and NCI-ADR) cell lines.	copolymer	138-147	PGP	Canis lupus familiaris	292-295
22397922-3	2012	The protecting amine group (Boc) was selectively deprotected and the latter targeted copolymer was produced through the reaction of this copolymer with activated folic acid.	copolymer	85-94	BOC cell adhesion associated, oncogene regulated	Homo sapiens	28-31
22417133-2	2012	This histidine-rich elastin-like polypeptide block copolymer self-assembles at 37  C into spherical micelles that are stabilized by Zn(2+) and are disrupted as the pH drops from 7.4 to 6.4.	copolymer	51-60	elastin	Homo sapiens	20-27
22354326-4	2012	The PLGA-PEG block copolymer was first synthesized and characterized by FTIR, (1)H NMR, GPC and inherent viscosity measurements.	copolymer	19-28	glycophorin C (Gerbich blood group)	Homo sapiens	88-91
24250467-0	2012	Preparation, Characterization and Pharmacodynamic Evaluation of Fused Dispersions of Simvastatin using PEO-PPO Block Copolymer.	copolymer	117-126	protoporphyrinogen oxidase	Homo sapiens	107-110
24250467-2	2012	Fused dispersions (FDs) of simvastatin (SIM) using PEO-PPO block copolymer were prepared which paved the way for the formation of an amorphous product with enhanced dissolution and bioavailability.	copolymer	65-74	protoporphyrinogen oxidase	Homo sapiens	55-58
24250467-3	2012	The accumulative solubility of simvastatin (SIM) from PEO-PPO block copolymer (Lutrol NF 127 prill surfactant) was found to be superior to the drug alone which may be due to the increased oxyethylene content that played the major role in solubility enhancement.	copolymer	68-77	protoporphyrinogen oxidase	Homo sapiens	58-61
22281424-3	2012	The anti-cancer drug, doxorubicin (DOX) was covalently conjugated onto the hydrophobic segments of the amphiphilic block copolymer arms (i.e., PLG) via a pH-labile hydrazone linkage to enable pH-controlled drug release.	copolymer	121-130	plasminogen	Homo sapiens	143-146
22203325-0	2012	Protected graft copolymer (PGC) basal formulation of insulin as potentially safer alternative to Lantus  (insulin-glargine): a streptozotocin-induced, diabetic Sprague Dawley rats study.	copolymer	16-25	insulin	Homo sapiens	53-60
22203325-2	2012	METHODS: Development of protected graft copolymer (PGC) excipients that bind native human insulin non-covalently and testing blood glucose control obtained with these formulations in streptozotocin-induced diabetic Sprague Dawley rats compared to equally dosed insulin glargine.	copolymer	40-49	insulin	Homo sapiens	90-97
22350800-7	2012	The HA-modified HPMA-copolymer PTX conjugate (P-(HA)(34)-PTX) exhibited 50-times higher cytotoxicity towards CD44-overexpressing cells relative to the control, non-targeted, HPMA-copolymer PTX conjugate (P-PTX).	copolymer	21-30	CD44 molecule (Indian blood group)	Homo sapiens	109-113