PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
24082892-7	2013	A series of 3-hydroxypyridine-4-one derivatives were prepared in high yield and evaluated for their inhibitory activity on tyrosinase enzyme using dopachrome method.	3-hydroxy-4-pyridone	12-35	tyrosinase	Homo sapiens	123-133
32380385-2	2020	These compounds were designed as dual binding site AChE inhibitors: they possess an arylalkylamine moiety connected via an alkyl chain to a 3-hydroxy-4-pyridone fragment, to allow the simultaneous interaction with catalytic active site (CAS) and peripheral anionic site (PAS) of the enzyme.	3-hydroxy-4-pyridone	140-160	acetylcholinesterase (Cartwright blood group)	Homo sapiens	51-55