PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
28264467-0	2017	Derivate Isocorydine (d-ICD) Suppresses Migration and Invasion of Hepatocellular Carcinoma Cell by Downregulating ITGA1 Expression.	isocorydine	9-20	integrin subunit alpha 1	Homo sapiens	114-119
32774728-0	2020	Isocorydine decrease gemcitabine-resistance by inhibiting epithelial-mesenchymal transition via STAT3 in pancreatic cancer cells.	isocorydine	0-11	signal transducer and activator of transcription 3	Homo sapiens	96-101
29171235-5	2017	This paper investigated the structure-activity relationship of isocorydine and its derivatives with anticancer activity in the aspect of stereochemical structure, functional groups positions of the compounds and the electron density of aromatic rings based on the single crystal diffraction structure and the molecular docking of EGFR and isocorydine.	isocorydine	63-74	epidermal growth factor receptor	Homo sapiens	330-334
25120059-4	2014	The results suggested that the isocorydine structural modifications at C-8 could significantly improve the biological activity of this alkaloid, indicating its suitability as a lead compound in the development of an effective anticancer agent.	isocorydine	31-42	homeobox C8	Homo sapiens	71-74
26327240-0	2015	An isocorydine derivative (d-ICD) inhibits drug resistance by downregulating IGF2BP3 expression in hepatocellular carcinoma.	isocorydine	3-14	insulin like growth factor 2 mRNA binding protein 3	Homo sapiens	77-84
26327240-1	2015	In our previous studies, we reported that CD133(+) cancer stem cells (CSCs) were chemoresistant in hepatocellular carcinoma (HCC) and that isocorydine treatment decreased the percentage of CD133(+) CSCs.	isocorydine	139-150	prominin 1	Homo sapiens	42-47
26327240-1	2015	In our previous studies, we reported that CD133(+) cancer stem cells (CSCs) were chemoresistant in hepatocellular carcinoma (HCC) and that isocorydine treatment decreased the percentage of CD133(+) CSCs.	isocorydine	139-150	prominin 1	Homo sapiens	189-194
26327240-2	2015	Here, we found that a derivative of isocorydine (d-ICD) inhibited HCC cell growth, particularly among the CD133(+) subpopulation, and rendered HCC cells more sensitive to sorafenib treatment.	isocorydine	36-47	prominin 1	Homo sapiens	106-111
22714713-0	2012	Isocorydine targets the drug-resistant cellular side population through PDCD4-related apoptosis in hepatocellular carcinoma.	isocorydine	0-11	programmed cell death 4	Homo sapiens	72-77
22623962-3	2012	We report that isocorydine induces G2/M phase arrest by increasing cyclin B1 and p-CDK1 expression levels, which was caused by decreasing the expression and inhibiting the activation of Cdc25C.	isocorydine	15-26	cyclin B1	Homo sapiens	67-76
22623962-3	2012	We report that isocorydine induces G2/M phase arrest by increasing cyclin B1 and p-CDK1 expression levels, which was caused by decreasing the expression and inhibiting the activation of Cdc25C.	isocorydine	15-26	cyclin dependent kinase 1	Homo sapiens	83-87
22623962-3	2012	We report that isocorydine induces G2/M phase arrest by increasing cyclin B1 and p-CDK1 expression levels, which was caused by decreasing the expression and inhibiting the activation of Cdc25C.	isocorydine	15-26	cell division cycle 25C	Homo sapiens	186-192