PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
9618353-8	1998	5 years, a positive association between BPb and EPO (beta = 0.21; p = 0.0001), controlled for Hgb, was found.	bpb	40-43	erythropoietin	Homo sapiens	48-51
9505142-5	1998	The upregulation of IL-6 production induced by BK was abolished by the anti-inflammatory agent dexamethasone (DEX) and the phospholipase A2 (PLA2) inhibitor 4-bromphenacyl bromide (BPB).	bpb	181-184	interleukin 6	Homo sapiens	20-24
9505142-5	1998	The upregulation of IL-6 production induced by BK was abolished by the anti-inflammatory agent dexamethasone (DEX) and the phospholipase A2 (PLA2) inhibitor 4-bromphenacyl bromide (BPB).	bpb	181-184	kininogen 1	Homo sapiens	47-49
9505142-5	1998	The upregulation of IL-6 production induced by BK was abolished by the anti-inflammatory agent dexamethasone (DEX) and the phospholipase A2 (PLA2) inhibitor 4-bromphenacyl bromide (BPB).	bpb	181-184	phospholipase A2 group IB	Homo sapiens	123-139
9505142-5	1998	The upregulation of IL-6 production induced by BK was abolished by the anti-inflammatory agent dexamethasone (DEX) and the phospholipase A2 (PLA2) inhibitor 4-bromphenacyl bromide (BPB).	bpb	181-184	phospholipase A2 group IB	Homo sapiens	141-145
9300928-5	1997	The p-value for SPb versus BPb is 12 orders of magnitude stronger than the p-value for percent pre-1940 housing versus BPb.	bpb	27-30	surfactant protein B	Homo sapiens	16-19
9891124-9	1997	3) Multiple correlation analysis showed a negative dose-response relationship between BPb and CaM activity.	bpb	86-89	calmodulin 1	Homo sapiens	94-97
9300928-8	1997	Census tracts with high SPb are associated with high BPb and census tracts with low SPb are associated with low BPb (Fisher"s exact test, p = 3.18 X 10(-24) for BPb versus SPb).	bpb	53-56	surfactant protein B	Homo sapiens	24-27
7684901-2	1993	(1) The phospholipase A2 blocker p-bromophenacyl bromide (BPB) inhibited the phorbol 12-myristate 13-acetate (PMA)-induced activation of this channel in a concentration-dependent manner (IC50, 4 microM).	bpb	58-61	phospholipase A2 group IB	Homo sapiens	8-24
8666362-6	1996	Three (50%) BPB and WDFA stained for p53 and five (83%) for MDM2.	bpb	12-15	tumor protein p53	Homo sapiens	37-40
8111460-10	1994	When these exposure indices were entered separately into the regression equation, CBPb accounted for 36.3% of the variation in NAG-B activity, 5.7% was accounted for by TBPb and 2.7% by BPb.	bpb	83-86	O-GlcNAcase	Homo sapiens	127-130
1658188-8	1991	TNF-stimulated DAG production as well as PKC activation could be blocked by the phospholipase inhibitor p-bromophenacylbromide (BPB).	bpb	128-131	tumor necrosis factor	Homo sapiens	0-3
8495215-2	1993	The maximal cooperative effect, specific for thrombin as inducer and potentiated by exogenous calcium, was observed at 2 microM BPB.	bpb	128-131	coagulation factor II, thrombin	Homo sapiens	45-53
1580258-4	1992	In the gun metal foundry workers, the latencies of P300 and N100 were significantly prolonged; the latency of P300 was significantly correlated with BPb concentrations and other indicators of lead absorption.	bpb	149-152	E1A binding protein p300	Homo sapiens	110-114
3927314-2	1985	Bromophenacyl bromide (BPB: phospholipase A2 inhibitor), and AA861 (5-lipoxygenase inhibitor) suppressed the production of 14C-alkyl-acetyl GPC in the A23187-stimulated prelabeled macrophages in a dose-dependent manner.	bpb	23-26	phospholipase A2 group IB	Rattus norvegicus	28-44
2656765-8	1989	beta G levels were significantly correlated with populations of spirochetes, B. intermedius, B. gingivalis, and total lactose negative BPB"s.	bpb	135-138	glucuronidase beta	Homo sapiens	0-6
1950816-4	1991	The protein kinase C inhibitor, H-7, and the phospholipase A2 inhibitor, BPB, both prevented drug-mediated activation of superoxide generation by PMNL.	bpb	73-76	phospholipase A2 group IB	Homo sapiens	45-61
3106986-4	1987	BPB at concentrations of 1-10 microM also inhibited the mitogenic effect of PRL in a concentration response fashion.	bpb	0-3	prolactin	Homo sapiens	76-79
3781471-1	1986	p-Bromphenacyl bromide (BPB) at concentrations of 50 microM and above and quinacrine (50 microM) abolished the actions of prolactin (PRL) on casein and lipid biosynthesis in cultured mouse mammary gland explants.	bpb	24-27	prolactin	Mus musculus	122-131
3781471-3	1986	Since BPB and quinacrine are known to inhibit the enzyme phospholipase A2 (PLA2), it is possible that ongoing PLA2 activity is essential for prolactin to express its actions on at least certain lactogenic processes.	bpb	6-9	phospholipase A2, group IB, pancreas	Mus musculus	57-73
3781471-3	1986	Since BPB and quinacrine are known to inhibit the enzyme phospholipase A2 (PLA2), it is possible that ongoing PLA2 activity is essential for prolactin to express its actions on at least certain lactogenic processes.	bpb	6-9	phospholipase A2, group IB, pancreas	Mus musculus	75-79
3781471-3	1986	Since BPB and quinacrine are known to inhibit the enzyme phospholipase A2 (PLA2), it is possible that ongoing PLA2 activity is essential for prolactin to express its actions on at least certain lactogenic processes.	bpb	6-9	phospholipase A2, group IB, pancreas	Mus musculus	110-114
3781471-3	1986	Since BPB and quinacrine are known to inhibit the enzyme phospholipase A2 (PLA2), it is possible that ongoing PLA2 activity is essential for prolactin to express its actions on at least certain lactogenic processes.	bpb	6-9	prolactin	Mus musculus	141-150
3927314-2	1985	Bromophenacyl bromide (BPB: phospholipase A2 inhibitor), and AA861 (5-lipoxygenase inhibitor) suppressed the production of 14C-alkyl-acetyl GPC in the A23187-stimulated prelabeled macrophages in a dose-dependent manner.	bpb	23-26	glycophorin C	Rattus norvegicus	140-143
25301235-7	2014	In addition, we confirmed that the expression of both cAMP responsive element-binding protein (CREB) and brain-derived neurotrophic factor (BDNF) in the hippocampus of Abeta(1-42)-injected mice were markedly upregulated by the treatment of BPB-316.	bpb	240-243	cAMP responsive element binding protein 1	Mus musculus	54-93
3972457-3	1985	p-Bromophenylacyl bromide (BPB) inhibits the phospholipase A2 activity of neutrophil acid extracts with an IC50 of 10 microM.	bpb	27-30	phospholipase A2 group IB	Homo sapiens	45-61
3972457-4	1985	In contrast, intact neutrophils incubated for up to 1 h with BPB, washed to remove the drug, and sonicated to expose the phospholipase A2, lose less than 20% of their activity.	bpb	61-64	phospholipase A2 group IB	Homo sapiens	121-137
31195007-5	2019	The results clearly revealed that BPA and the NextGen bisphenols of BPAF, BPAP, BPB, BPC, BPE, and BPZ were highly potent against one or more of NRs such as CAR, ERalpha, ERbeta, ERRgamma, and GR, with IC50 values of 3.3-73 nM.	bpb	80-83	estrogen receptor 2	Homo sapiens	171-177
31195007-5	2019	The results clearly revealed that BPA and the NextGen bisphenols of BPAF, BPAP, BPB, BPC, BPE, and BPZ were highly potent against one or more of NRs such as CAR, ERalpha, ERbeta, ERRgamma, and GR, with IC50 values of 3.3-73 nM.	bpb	80-83	estrogen related receptor gamma	Homo sapiens	179-187
31195007-5	2019	The results clearly revealed that BPA and the NextGen bisphenols of BPAF, BPAP, BPB, BPC, BPE, and BPZ were highly potent against one or more of NRs such as CAR, ERalpha, ERbeta, ERRgamma, and GR, with IC50 values of 3.3-73 nM.	bpb	80-83	CXADR pseudogene 1	Homo sapiens	157-160
31195007-5	2019	The results clearly revealed that BPA and the NextGen bisphenols of BPAF, BPAP, BPB, BPC, BPE, and BPZ were highly potent against one or more of NRs such as CAR, ERalpha, ERbeta, ERRgamma, and GR, with IC50 values of 3.3-73 nM.	bpb	80-83	estrogen receptor 1	Homo sapiens	162-169
29145054-7	2018	We did not find a statistically significant association between prenatal BPb levels and birth outcomes; in stratified analyses, the association between higher BPb level during early pregnancy and lower birthweight (beta=-224 per square root increase in BPb; 95% confidence interval (CI): -426, -21; false discovery rate p=0.036) was significant in males of mothers with GSTM1 null.	bpb	159-162	glutathione S-transferase mu 1	Homo sapiens	370-375
29145054-7	2018	We did not find a statistically significant association between prenatal BPb levels and birth outcomes; in stratified analyses, the association between higher BPb level during early pregnancy and lower birthweight (beta=-224 per square root increase in BPb; 95% confidence interval (CI): -426, -21; false discovery rate p=0.036) was significant in males of mothers with GSTM1 null.	bpb	159-162	glutathione S-transferase mu 1	Homo sapiens	370-375
29145054-10	2018	For combined analysis with GSTM1 and GSTT1, GSTM1 null and GSTT1 present group showed a significant inverse association of BPb with birthweight and head circumference in males.	bpb	123-126	glutathione S-transferase mu 1	Homo sapiens	27-32
29145054-10	2018	For combined analysis with GSTM1 and GSTT1, GSTM1 null and GSTT1 present group showed a significant inverse association of BPb with birthweight and head circumference in males.	bpb	123-126	glutathione S-transferase theta 1	Homo sapiens	37-42
29145054-10	2018	For combined analysis with GSTM1 and GSTT1, GSTM1 null and GSTT1 present group showed a significant inverse association of BPb with birthweight and head circumference in males.	bpb	123-126	glutathione S-transferase mu 1	Homo sapiens	44-49
29145054-10	2018	For combined analysis with GSTM1 and GSTT1, GSTM1 null and GSTT1 present group showed a significant inverse association of BPb with birthweight and head circumference in males.	bpb	123-126	glutathione S-transferase theta 1	Homo sapiens	59-64
29145054-11	2018	Our findings of the most evident effects of BPb on the reduced birthweight and head circumference in male born to the mother with GSTM1 null may suggest a biological interaction among lead, GST genes and sex in detoxification process during fetal development.	bpb	44-47	glutathione S-transferase mu 1	Homo sapiens	130-135
25301235-7	2014	In addition, we confirmed that the expression of both cAMP responsive element-binding protein (CREB) and brain-derived neurotrophic factor (BDNF) in the hippocampus of Abeta(1-42)-injected mice were markedly upregulated by the treatment of BPB-316.	bpb	240-243	cAMP responsive element binding protein 1	Mus musculus	95-99
25301235-7	2014	In addition, we confirmed that the expression of both cAMP responsive element-binding protein (CREB) and brain-derived neurotrophic factor (BDNF) in the hippocampus of Abeta(1-42)-injected mice were markedly upregulated by the treatment of BPB-316.	bpb	240-243	brain derived neurotrophic factor	Mus musculus	105-138
25301235-7	2014	In addition, we confirmed that the expression of both cAMP responsive element-binding protein (CREB) and brain-derived neurotrophic factor (BDNF) in the hippocampus of Abeta(1-42)-injected mice were markedly upregulated by the treatment of BPB-316.	bpb	240-243	brain derived neurotrophic factor	Mus musculus	140-144
19121070-7	2009	RESULTS: The results showed that A. actinomycetemcomitans lipopolysaccharide stimulated both iNOS activity and nitrite production by HOS cells; this was reduced by l-NIL, anti-CD14, or anti-TLR4 antibody, SQ22536, KT5720, genistein, bisindolylmaleimde, BPB, and NDGA, but was enhanced by db-cAMP, IBMX, and forskolin.	bpb	253-256	nitric oxide synthase 2	Homo sapiens	93-97
23359659-9	2013	This finding provides a means to predict the magnitude of P-gp-based drug interactions at the BBB and BPB when only the baseline distribution of the drug (i.e., in the absence of P-gp inhibition) across these barriers is available through PET.	bpb	102-105	ATP binding cassette subfamily B member 1	Homo sapiens	58-62
29430074-2	2012	Two recent studies reported an increased risk of anemia in children with BPb between 10-20 microg dL-1, but few studies examined the association between Hb levels or risk of anemia and BPb under 10 microg dL-1.	bpb	73-76	l(1)L1	Drosophila melanogaster	98-102
20371382-3	2010	In this work, we present five structures of Lys49-PLA(2)s from snakes of the Bothrops genus in apo form, complexed with PEG molecules and chemically modified by p-bromofenacil bromide (BPB), a classic inhibitor of PLA(2).	bpb	185-188	phospholipase A2 group IIA	Homo sapiens	50-57
22845729-6	2012	Also, BPb was negatively correlated with serum Ca and, P, and positively correlated with systolic and diastolic blood pressures in pregnancy (r = -.804 for Ca, r = -.728 for P, r = .908 for SBP, and r = .842 for DBP) and preeclampsia (p < .01).	bpb	6-9	selenium binding protein 1	Homo sapiens	190-193
22845729-6	2012	Also, BPb was negatively correlated with serum Ca and, P, and positively correlated with systolic and diastolic blood pressures in pregnancy (r = -.804 for Ca, r = -.728 for P, r = .908 for SBP, and r = .842 for DBP) and preeclampsia (p < .01).	bpb	6-9	D-box binding PAR bZIP transcription factor	Homo sapiens	212-215
15354056-7	2004	The continued decline in the slope of the relationship between EPO and BPb with age, after adjustment for hemoglobin, implies a gradually decreasing capacity to produce EPO.	bpb	71-74	erythropoietin	Homo sapiens	63-66
17621417-11	2007	The levels of HYP, ALP, BALP, BGP in the BPb 300 approximately microg/L group were significantly higher than those in the BPb 0 approximately microg/L group (P < 0.05).	bpb	41-44	CEA cell adhesion molecule 1	Homo sapiens	30-33
15954127-9	2005	There was an interaction between BPb concentration and ALAD allele status; the odds of ET were greatly elevated in individuals with both an ALAD-2 allele and an elevated BPb concentration.	bpb	33-36	aminolevulinate dehydratase	Homo sapiens	140-144
15954127-10	2005	The presence of increased circulating BPb concentrations along with a greater potential for lead toxicity (ALAD-2 allele) could result in greater cerebellar damage, thereby increasing the risk of developing tremor.	bpb	38-41	aminolevulinate dehydratase	Homo sapiens	107-111
15354056-7	2004	The continued decline in the slope of the relationship between EPO and BPb with age, after adjustment for hemoglobin, implies a gradually decreasing capacity to produce EPO.	bpb	71-74	erythropoietin	Homo sapiens	169-172
14648557-5	2004	Employing identified Helisoma neurons in vitro, we demonstrate that inhibition of PLA2 with 2 microM BPB caused a 40.3% increase in average filopodial length, as well as a 37.3% reduction in the number of filopodia on a growth cone.	bpb	101-104	phospholipase A2 group IB	Homo sapiens	82-86
14646278-6	2003	Since the cutoff value of ALA-P, computed from the latter workers, seems to be closer to the upper normal limit in unexposed adults than does that from the former workers, it is suggested that the critical dose of BPb causing the increased levels of ALA is below 10 microg/dl.	bpb	214-217	endoplasmic reticulum aminopeptidase 1	Homo sapiens	26-31