PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
26719708-19	2015	Pathological patterns of proliferation (r=0.37, P=0.04), GFAP (r=0.37, P=0.04), and Olig2 (r=0.36, P=0.05) showed a significant positive correlation with cortical URs.	Peptichemio	163-166	oligodendrocyte transcription factor 2	Homo sapiens	84-89
26935956-13	2016	We also observed upregulation of NOXA (up to 3.6 +- 1.2-fold induction, P = 0.009) and subsequent downregulation of myeloid cell leukemia 1 (MCL-1) protein levels, which likely mediates the apoptotic effects of PTC-209.	Peptichemio	211-214	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	33-37
26935956-13	2016	We also observed upregulation of NOXA (up to 3.6 +- 1.2-fold induction, P = 0.009) and subsequent downregulation of myeloid cell leukemia 1 (MCL-1) protein levels, which likely mediates the apoptotic effects of PTC-209.	Peptichemio	211-214	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	141-146
26863604-2	2016	A longstanding question is how Ptc inhibits Smo and how such inhibition is relieved by Hh stimulation.	Peptichemio	31-34	smoothened, frizzled class receptor	Mus musculus	44-47
26354280-5	2015	The impedimetric results of the FTO/ZnO/Urs biosensor showed a high sensitivity for urea detection within 8.0-110.0mg dL(-1) with the limit of detection as 5.0mg dL(-1).	Peptichemio	40-43	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	32-35
24632946-8	2014	In addition, the beta-catenin GOF mutants displayed reduced apoptosis and subsequently increased apoptosis in the URS epithelium.	Peptichemio	114-117	catenin beta 1	Homo sapiens	17-29
27125030-8	2015	The data obtained allow to hypothesize existence of evolutionary conserved mechanism that modulates Hh-signaling and based on the interaction of Zyxin with Ptc.	Peptichemio	156-159	zyxin	Homo sapiens	145-150
26037485-10	2015	The cat sequence for Tas2r38 contains 3 major amino acid residues known to confer the taster phenotype (PAI), which is associated with sensitivity to the bitter compounds PROP and PTC.	Peptichemio	180-183	taste 2 receptor member 38	Homo sapiens	21-28
26037485-11	2015	However, in contrast to human TAS2R38, cat Tas2r38 is activated by PTC but not by PROP.	Peptichemio	67-70	taste 2 receptor member 38	Homo sapiens	43-50
26037485-15	2015	Results with cat Tas2r38 also demonstrate that additional residues beyond those classically associated with PROP sensitivity in humans influence the sensitivity to PROP and PTC.	Peptichemio	173-176	taste 2 receptor member 38	Homo sapiens	17-24
26672717-10	2015	For URS serum TNF-a levels were statistical significantly correlated preoperatively with one hour (P=0,0083) and 48 hours (P<0,001) after URS and IL-6 with 2 and 24 hours (P<0,001).	Peptichemio	4-7	tumor necrosis factor	Homo sapiens	14-19
26672717-10	2015	For URS serum TNF-a levels were statistical significantly correlated preoperatively with one hour (P=0,0083) and 48 hours (P<0,001) after URS and IL-6 with 2 and 24 hours (P<0,001).	Peptichemio	141-144	tumor necrosis factor	Homo sapiens	14-19
26672717-13	2015	In conclusion, high pre ESWL/URS levels of serum TNF-a and IL-6 may indicate a predisposition for post ESWL/URS inflammation and infection following URS lithotripsy or ESWL procedure.	Peptichemio	29-32	tumor necrosis factor	Homo sapiens	49-54
26672717-13	2015	In conclusion, high pre ESWL/URS levels of serum TNF-a and IL-6 may indicate a predisposition for post ESWL/URS inflammation and infection following URS lithotripsy or ESWL procedure.	Peptichemio	29-32	interleukin 6	Homo sapiens	59-63
26153718-1	2015	In this paper, a novel electrochemiluminescence resonance energy transfer (ECL-RET) system from O2/S2O8(2-) to a kind of amino-terminated perylene derivative (PTC-NH2) was demonstrated for the first time, which was then applied to construct a ratiometric aptasensor for lead ion (Pb(2+)) detection.	Peptichemio	159-162	ret proto-oncogene	Homo sapiens	79-82
24632946-10	2014	The expression of bone morphogenetic protein (Bmp) genes, such as Bmp4 and Bmp7, was also ectopically induced in the epithelia of the URS in the beta-catenin GOF mutants.	Peptichemio	134-137	bone morphogenetic protein 1	Homo sapiens	18-44
24632946-10	2014	The expression of bone morphogenetic protein (Bmp) genes, such as Bmp4 and Bmp7, was also ectopically induced in the epithelia of the URS in the beta-catenin GOF mutants.	Peptichemio	134-137	bone morphogenetic protein 1	Homo sapiens	46-49
24632946-10	2014	The expression of bone morphogenetic protein (Bmp) genes, such as Bmp4 and Bmp7, was also ectopically induced in the epithelia of the URS in the beta-catenin GOF mutants.	Peptichemio	134-137	bone morphogenetic protein 4	Homo sapiens	66-70
24632946-10	2014	The expression of bone morphogenetic protein (Bmp) genes, such as Bmp4 and Bmp7, was also ectopically induced in the epithelia of the URS in the beta-catenin GOF mutants.	Peptichemio	134-137	bone morphogenetic protein 7	Homo sapiens	75-79
24632946-10	2014	The expression of bone morphogenetic protein (Bmp) genes, such as Bmp4 and Bmp7, was also ectopically induced in the epithelia of the URS in the beta-catenin GOF mutants.	Peptichemio	134-137	catenin beta 1	Homo sapiens	145-157
24632946-13	2014	The Shh(CreERT2/+); beta-catenin(flox(ex3)/+); BmprIA(flox/-) mutants displayed partial restoration of URS elongation compared with the beta-catenin GOF mutants.	Peptichemio	103-106	catenin beta 1	Homo sapiens	20-32
24632949-3	2014	Recent studies only focused on the importance of urs mesenchyme proliferation, which is induced by endoderm-derived Sonic Hedgehog (Shh).	Peptichemio	49-52	sonic hedgehog signaling molecule	Homo sapiens	116-130
24632949-3	2014	Recent studies only focused on the importance of urs mesenchyme proliferation, which is induced by endoderm-derived Sonic Hedgehog (Shh).	Peptichemio	49-52	sonic hedgehog signaling molecule	Homo sapiens	132-135
24632949-9	2014	Taken altogether, these data suggest that regulated expression of Wif1 is critical for the growth of the urs during cloaca septation.	Peptichemio	105-108	WNT inhibitory factor 1	Homo sapiens	66-70
24632949-10	2014	Hence, Wif1 governs cell apoptosis of urs endoderm by repressing beta-catenin signal, which may facilitate the protrusion of the underlying proliferating mesenchymal cells towards the cm for cloaca septation.	Peptichemio	38-41	WNT inhibitory factor 1	Homo sapiens	7-11
24632949-10	2014	Hence, Wif1 governs cell apoptosis of urs endoderm by repressing beta-catenin signal, which may facilitate the protrusion of the underlying proliferating mesenchymal cells towards the cm for cloaca septation.	Peptichemio	38-41	catenin beta 1	Homo sapiens	65-77
24605247-10	2014	IL-6 levels were found statistically significant, elevated after 2 and 24 hours from the URS (P < 0.001).	Peptichemio	89-92	interleukin 6	Homo sapiens	0-4
21296759-6	2011	Notably, overexpression of Rph1 and H3K36A mutant reduced histone acetylation at the URS, which implies a crosstalk between histone demethylation and acetylation at the PHR1 promoter.	Peptichemio	85-88	Rph1p	Saccharomyces cerevisiae S288C	27-31
24389432-9	2013	CONCLUSIONS: SB3-positive immunohistochemistry score of 2 or more (>10% tumor cells positive) identifies a subgroup of patients with stage IV NSCLC who have a poor survival (median 120 days) when treated with PtC, similar to that estimated for untreated or chemo-refractory stage IV NSCLC.	Peptichemio	212-215	serpin family B member 3	Homo sapiens	13-16
24049373-12	2013	In the Perc-URS group, 21 patients (95.45%) had complete calculus clearance through a single tract in one session of percutaneous surgery, whereas in the URS group, only 20 patients (66.7%) had complete stone clearance (P = 0.007).	Peptichemio	12-15	PPARG coactivator 1 beta	Homo sapiens	7-11
22990626-11	2013	Concomitant with the fall in values of NK cells, in athletes that shown more than three URS episodes, a moderate correlation (r = 0.493; p = 0.036) was found between CD56(bright)/CD56(dim) ratio and the number of URS episodes after the more demanding training phase (t3).	Peptichemio	88-91	neural cell adhesion molecule 1	Homo sapiens	166-170
22990626-11	2013	Concomitant with the fall in values of NK cells, in athletes that shown more than three URS episodes, a moderate correlation (r = 0.493; p = 0.036) was found between CD56(bright)/CD56(dim) ratio and the number of URS episodes after the more demanding training phase (t3).	Peptichemio	88-91	neural cell adhesion molecule 1	Homo sapiens	179-183
22990626-11	2013	Concomitant with the fall in values of NK cells, in athletes that shown more than three URS episodes, a moderate correlation (r = 0.493; p = 0.036) was found between CD56(bright)/CD56(dim) ratio and the number of URS episodes after the more demanding training phase (t3).	Peptichemio	213-216	neural cell adhesion molecule 1	Homo sapiens	166-170
22990626-11	2013	Concomitant with the fall in values of NK cells, in athletes that shown more than three URS episodes, a moderate correlation (r = 0.493; p = 0.036) was found between CD56(bright)/CD56(dim) ratio and the number of URS episodes after the more demanding training phase (t3).	Peptichemio	213-216	neural cell adhesion molecule 1	Homo sapiens	179-183
22990626-12	2013	At t3, a lower value of CD56 cell counts was found in the group who reported three or more URS episodes (t = 2.239; p = 0.032).	Peptichemio	91-94	neural cell adhesion molecule 1	Homo sapiens	24-28
23322450-2	2013	T2R38 was initially identified in the quest to understand the variability in bitter taste perception to the compound phenylthiocarbamide (PTC) and demonstrated to have polymorphisms generating diplotypes dividing people into PTC supertasters, heterozygotes (with variable PTC detection), and nontasters.	Peptichemio	138-141	taste 2 receptor member 38	Homo sapiens	0-5
20531374-4	2011	We find a significant association between DISC1 missense variants and URS.	Peptichemio	70-73	DISC1 scaffold protein	Homo sapiens	42-47
21296759-6	2011	Notably, overexpression of Rph1 and H3K36A mutant reduced histone acetylation at the URS, which implies a crosstalk between histone demethylation and acetylation at the PHR1 promoter.	Peptichemio	85-88	deoxyribodipyrimidine photo-lyase PHR1	Saccharomyces cerevisiae S288C	169-173
22070050-3	2011	CK-19 was positive in 91% (62/68) DTC, 98% (51/52) PTC, 69% (11/16) FTC and 15% (3/20) benign thyroid nodules.	Peptichemio	51-54	keratin 19	Homo sapiens	0-5
21253826-6	2011	Our study demonstrated that after both PTC 124 and gentamicin treatment, there was an increase in CPT1 activity in patient fibroblasts to levels that are similar to that of the mild Inuit P479L variant.	Peptichemio	39-42	carnitine palmitoyltransferase 1A	Homo sapiens	98-102
21332312-7	2011	However, one haplotype spanning UCP4 was found to be significantly under-represented in URS patients.	Peptichemio	88-91	solute carrier family 25 member 27	Homo sapiens	32-36
21332312-9	2011	CONCLUSION: Although our sample is of limited size and not representative of schizophrenia as a whole, the association found between the URS group and the UCP4 haplotype is noteworthy as it may influence treatment outcome in schizophrenia.	Peptichemio	137-140	solute carrier family 25 member 27	Homo sapiens	155-159
20416345-3	2010	Addition of NF1 and URS to EP (NEP and UNEP) or EPEI (NEPEI and UNEPEI) results in a lesser effect on the expression.	Peptichemio	20-23	membrane metalloendopeptidase	Homo sapiens	31-34
14517335-6	2003	Promoter analysis of FLO11 identifies one upstream activation sequence (UASR) and one repression site (URS) that confer regulation by amino acid starvation.	Peptichemio	103-106	Flo11p	Saccharomyces cerevisiae S288C	21-26
20839488-11	2010	The IL-6 high-expression genotype was associated with an increased likelihood of > or =3 URS episodes in a 12 month period (odds ratio (OR): 2.87, 95% confidence interval (CI): 1.10-7.53; p = 0.03).	Peptichemio	92-95	interleukin 6	Homo sapiens	4-8
20839488-12	2010	The IL-2 high-expression genotype was associated with a tendency for a decreased likelihood of > or =3 URS episodes in a 12 month period (OR: 0.361, 95% CI: 0.124-1.06; p = 0.06).	Peptichemio	106-109	interleukin 2	Homo sapiens	4-8
19302865-12	2009	RESULTS: On the immunologic labeling study, EphB2 expression was confined to the cloaca in control groups, whereas EphB2 expression was mainly located at the urorectal septum (URS) and cloacal membrane on Gd13 and Gd14.	Peptichemio	176-179	Eph receptor B2	Rattus norvegicus	115-120
17234669-9	2007	CONCLUSIONS: Direct injection of OCT into the PTG enables the administration of the highly concentrated drug for specific binding to nuclear vitamin D binding sites, including VDR of PTC, which markedly suppresses the parathyroid hormone, improves the response to calcium and vitamin D and induces apoptosis in PTC.	Peptichemio	183-186	vitamin D receptor	Rattus norvegicus	176-179
12799307-6	2003	Using confocal microscopy with a novel antibody raised against the predicted extracellular NH2 terminus of human NHE3, we observed in nonpermeabilized cells that exposure of PTC to albumin (0.1 and 1.0 mg/ml) increased NHE3 at the cell surface to 115.4 +/- 2.7% (P < 0.0005) and 122.4 +/- 3.7% (P < 0.0001) of control levels, respectively.	Peptichemio	174-177	solute carrier family 9 member A3	Homo sapiens	113-117
12799307-6	2003	Using confocal microscopy with a novel antibody raised against the predicted extracellular NH2 terminus of human NHE3, we observed in nonpermeabilized cells that exposure of PTC to albumin (0.1 and 1.0 mg/ml) increased NHE3 at the cell surface to 115.4 +/- 2.7% (P < 0.0005) and 122.4 +/- 3.7% (P < 0.0001) of control levels, respectively.	Peptichemio	174-177	solute carrier family 9 member A3	Homo sapiens	219-223
17942488-5	2007	We show that FOS-1 is expressed at pi cell specification and can bind in vitro to egl-13 upstream regulatory sequence (URS) as a heterodimer with C. elegans Jun.	Peptichemio	119-122	Transcription factor fos-1	Caenorhabditis elegans	13-18
17942488-5	2007	We show that FOS-1 is expressed at pi cell specification and can bind in vitro to egl-13 upstream regulatory sequence (URS) as a heterodimer with C. elegans Jun.	Peptichemio	119-122	HMG box domain-containing protein;Transcription factor egl-13	Caenorhabditis elegans	82-88
16723984-8	2006	In cultured MC and PTC, aldosterone induced significant increases in CTGF gene expression and protein synthesis associated with increased collagen synthesis, which was abolished by prior treatment with spironolactone.	Peptichemio	19-22	cellular communication network factor 2	Rattus norvegicus	69-73
15581865-7	2004	Ptc encircles the dense Shh immunoproduct in papillae at various stages.	Peptichemio	0-3	sonic hedgehog signaling molecule	Rattus norvegicus	24-27
14736958-5	2004	RESULTS: In the in vitro model, hypoxia (1% O(2)) induced a significant degree of PTC apoptosis, which was substantially reduced by co-incubation with EPO at 24 h (vehicle 2.5+/-0.5% vs 25 IU/ml EPO 1.8+/-0.4% vs 200 IU/ml EPO 0.9+/-0.2%, n = 9, P<0.05).	Peptichemio	82-85	erythropoietin	Rattus norvegicus	151-154
14517335-7	2003	Gcn4p is not required for regulation of the UASR by amino acid starvation, but seems to be indirectly required to overcome the negative effects of the URS on FLO11 transcription.	Peptichemio	151-154	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	0-5
14517335-7	2003	Gcn4p is not required for regulation of the UASR by amino acid starvation, but seems to be indirectly required to overcome the negative effects of the URS on FLO11 transcription.	Peptichemio	151-154	Flo11p	Saccharomyces cerevisiae S288C	158-163
14507971-6	2003	Alternatively, if ACe damage selectively interferes with CR formation, maintenance, or expression, then both freezing and USV should be blocked or impaired when elicited as CRs during acquisition and retention testing but spared when evoked as unconditional responses (URs) to ejaculation.	Peptichemio	269-272	angiotensin I converting enzyme	Rattus norvegicus	18-21
12051917-6	2002	We analyzed the function of the SACE of the left arm of chromosome VIII in vivo and found its ATF/CREB site to act as UAS/URS of the COS8 promoter, effected by the yeast bZip proteins Sko1p, Aca1p, and Aca2p.	Peptichemio	122-125	Cos8p	Saccharomyces cerevisiae S288C	133-137
12816775-12	2003	CONCLUSION: The association between diet and fasting insulin differed between URs and non-URs in this study of 301 healthy men aged 63 y.	Peptichemio	78-81	insulin	Homo sapiens	53-60
12051917-6	2002	We analyzed the function of the SACE of the left arm of chromosome VIII in vivo and found its ATF/CREB site to act as UAS/URS of the COS8 promoter, effected by the yeast bZip proteins Sko1p, Aca1p, and Aca2p.	Peptichemio	122-125	Sko1p	Saccharomyces cerevisiae S288C	184-189
12051917-6	2002	We analyzed the function of the SACE of the left arm of chromosome VIII in vivo and found its ATF/CREB site to act as UAS/URS of the COS8 promoter, effected by the yeast bZip proteins Sko1p, Aca1p, and Aca2p.	Peptichemio	122-125	Aca1p	Saccharomyces cerevisiae S288C	191-196
12051917-6	2002	We analyzed the function of the SACE of the left arm of chromosome VIII in vivo and found its ATF/CREB site to act as UAS/URS of the COS8 promoter, effected by the yeast bZip proteins Sko1p, Aca1p, and Aca2p.	Peptichemio	122-125	Cst6p	Saccharomyces cerevisiae S288C	202-207
11961008-10	2002	In conclusion, human renal OPN localization in cell cultures demonstrated differences between PTC and DTC comparable to those observed after renal ischemia in vivo.	Peptichemio	94-97	secreted phosphoprotein 1	Homo sapiens	27-30
10705372-3	2000	In our previous work, we have shown that there are two elements acting as TUP1-dependent upstream repression sequence (URS) and tup1 mutation-dependent upstream activation sequence (UAS) between nt -915 and -621 of the IME1 promoter under nutritional conditions.	Peptichemio	119-122	chromatin-silencing transcriptional regulator TUP1	Saccharomyces cerevisiae S288C	74-78
11459833-5	2001	Consequently, the binding of Rfa2p to upstream repressing sequences (URS) of repair genes is decreased, thereby leading to their derepression.	Peptichemio	69-72	Rfa2p	Saccharomyces cerevisiae S288C	29-34
11459833-7	2001	Moreover, we show that the deletion of the amino-terminal region of Rfa2p suppresses the sensitivity to ultraviolet radiation of a mec3Delta checkpoint mutant, abolishes the URS-mediated repression, and increases the expression of repair genes.	Peptichemio	174-177	Rfa2p	Saccharomyces cerevisiae S288C	68-73
11513817-8	2001	Measurements obtained before ingestion of the AA drink indicated that, relative to control subjects URs exhibited lower serotonin platelet concentrations, lower affinity, and fewer binding sites of the serotonin transporter for imipramine; these differences were unaffected by ATD.	Peptichemio	100-103	solute carrier family 6 member 4	Homo sapiens	202-223
11104700-5	2000	The complex character of URS(1) includes the presence of two different cis-acting sequences: (i) a RAP1 (repressor activator protein 1)-binding site that is capable of binding the RAP1 protein in vitro and (ii) two putative ethanol-repression sequences, the modification of which derepresses the AAC3 gene.	Peptichemio	25-28	ADP/ATP carrier protein AAC3	Saccharomyces cerevisiae S288C	296-300
11097841-4	2000	We also revealed that the 28-bp region fused with a reporter gene harbored Yhp1-dependent URS (upstream repression sequence) activity and that the transcription of YHP1 was repressed by nonfermentable carbon source.	Peptichemio	90-93	Yhp1p	Saccharomyces cerevisiae S288C	75-79
11097841-5	2000	In this study, we found, using a 5"-deletion series of the YHP1 promoter fused with a reporter gene, that the URS responsible for repression of YHP1 transcription with a nonfermentable carbon source is located at a region from nt -696 to -466 of the YHP1 promoter.	Peptichemio	110-113	Yhp1p	Saccharomyces cerevisiae S288C	59-63
11097841-5	2000	In this study, we found, using a 5"-deletion series of the YHP1 promoter fused with a reporter gene, that the URS responsible for repression of YHP1 transcription with a nonfermentable carbon source is located at a region from nt -696 to -466 of the YHP1 promoter.	Peptichemio	110-113	Yhp1p	Saccharomyces cerevisiae S288C	144-148
11097841-5	2000	In this study, we found, using a 5"-deletion series of the YHP1 promoter fused with a reporter gene, that the URS responsible for repression of YHP1 transcription with a nonfermentable carbon source is located at a region from nt -696 to -466 of the YHP1 promoter.	Peptichemio	110-113	Yhp1p	Saccharomyces cerevisiae S288C	144-148
11042356-9	2000	These studies further demonstrated that the NF-M 1.5 kb URS was highly susceptible to positional effects, a property that may be relevant to the highly variant, tissue-specific expression that is seen among members of the intermediate filament gene family.	Peptichemio	56-59	neurofilament medium chain L homeolog	Xenopus laevis	44-48
10705372-3	2000	In our previous work, we have shown that there are two elements acting as TUP1-dependent upstream repression sequence (URS) and tup1 mutation-dependent upstream activation sequence (UAS) between nt -915 and -621 of the IME1 promoter under nutritional conditions.	Peptichemio	119-122	transcription factor IME1	Saccharomyces cerevisiae S288C	219-223
10705372-7	2000	The region for binding of Yhp1 was delimited to the 28 bp region between nt -702 and -675 of the IME1 promoter in vivo and in vitro, and the 28 bp region harboured a URS activity in a Yhp1-dependent manner under nutrient growth conditions.	Peptichemio	166-169	Yhp1p	Saccharomyces cerevisiae S288C	26-30
10705372-7	2000	The region for binding of Yhp1 was delimited to the 28 bp region between nt -702 and -675 of the IME1 promoter in vivo and in vitro, and the 28 bp region harboured a URS activity in a Yhp1-dependent manner under nutrient growth conditions.	Peptichemio	166-169	Yhp1p	Saccharomyces cerevisiae S288C	184-188
9858577-5	1999	A second URS at -502 to -513 is responsible for transcriptional repression regulated by osmotic stress and is similar to mammalian cyclic AMP response elements (CREs) that are recognized by CREB proteins.	Peptichemio	9-12	cAMP responsive element binding protein 1	Homo sapiens	190-194
10523651-3	1999	The primary regulator of the PHR1 damage response is a 39-bp sequence called URS(PHR1) which is the binding site for a protein(s) that constitutes the damage-responsive repressor PRP.	Peptichemio	77-80	deoxyribodipyrimidine photo-lyase PHR1	Saccharomyces cerevisiae S288C	29-33
10523651-3	1999	The primary regulator of the PHR1 damage response is a 39-bp sequence called URS(PHR1) which is the binding site for a protein(s) that constitutes the damage-responsive repressor PRP.	Peptichemio	77-80	deoxyribodipyrimidine photo-lyase PHR1	Saccharomyces cerevisiae S288C	81-85
10523651-4	1999	In this communication, we report the identification of two proteins, Rph1p and Gis1p, that regulate PHR1 expression through URS(PHR1).	Peptichemio	124-127	Rph1p	Saccharomyces cerevisiae S288C	69-74
10523651-4	1999	In this communication, we report the identification of two proteins, Rph1p and Gis1p, that regulate PHR1 expression through URS(PHR1).	Peptichemio	124-127	histone demethylase GIS1	Saccharomyces cerevisiae S288C	79-84
10523651-4	1999	In this communication, we report the identification of two proteins, Rph1p and Gis1p, that regulate PHR1 expression through URS(PHR1).	Peptichemio	124-127	deoxyribodipyrimidine photo-lyase PHR1	Saccharomyces cerevisiae S288C	100-104
10523651-4	1999	In this communication, we report the identification of two proteins, Rph1p and Gis1p, that regulate PHR1 expression through URS(PHR1).	Peptichemio	124-127	deoxyribodipyrimidine photo-lyase PHR1	Saccharomyces cerevisiae S288C	128-132
10523651-7	1999	In vitro footprinting and binding competition studies indicate that the sequence AG(4) (C(4)T) within URS(PHR1) is the binding site for Rph1p and Gis1p and suggests that at least one additional DNA binding component is present in the PRP complex.	Peptichemio	102-105	deoxyribodipyrimidine photo-lyase PHR1	Saccharomyces cerevisiae S288C	106-110
10523651-7	1999	In vitro footprinting and binding competition studies indicate that the sequence AG(4) (C(4)T) within URS(PHR1) is the binding site for Rph1p and Gis1p and suggests that at least one additional DNA binding component is present in the PRP complex.	Peptichemio	102-105	Rph1p	Saccharomyces cerevisiae S288C	136-141
10523651-7	1999	In vitro footprinting and binding competition studies indicate that the sequence AG(4) (C(4)T) within URS(PHR1) is the binding site for Rph1p and Gis1p and suggests that at least one additional DNA binding component is present in the PRP complex.	Peptichemio	102-105	histone demethylase GIS1	Saccharomyces cerevisiae S288C	146-151
9560430-8	1998	We also demonstrated that the 294-bp fragment from nucleotide position -914 to -621 and the 301-bp fragment from nucleotide position -1215 to -915 of the IME1 promoter region contain elements acting as URS and UAS in TUP1+ and tup1 mutant cells, respectively.	Peptichemio	202-205	transcription factor IME1	Saccharomyces cerevisiae S288C	154-158
9658552-6	1998	IBat was significantly lower with 2 x QRS as compared with 2 x URS (13.43 +/- 1.0 vs. 14.20 +/- 1.2 microA, p < 0.01) and as compared with 3 x tRS (13.99 +/- 1.2 microA, p < 0.05).	Peptichemio	63-66	solute carrier family 10 member 2	Homo sapiens	0-4
9560430-8	1998	We also demonstrated that the 294-bp fragment from nucleotide position -914 to -621 and the 301-bp fragment from nucleotide position -1215 to -915 of the IME1 promoter region contain elements acting as URS and UAS in TUP1+ and tup1 mutant cells, respectively.	Peptichemio	202-205	chromatin-silencing transcriptional regulator TUP1	Saccharomyces cerevisiae S288C	217-221
9560430-8	1998	We also demonstrated that the 294-bp fragment from nucleotide position -914 to -621 and the 301-bp fragment from nucleotide position -1215 to -915 of the IME1 promoter region contain elements acting as URS and UAS in TUP1+ and tup1 mutant cells, respectively.	Peptichemio	202-205	chromatin-silencing transcriptional regulator TUP1	Saccharomyces cerevisiae S288C	227-231
9425123-4	1998	We have identified and partially purified a 27 kDa protein that binds specifically to both the UAS and URS sequences of the ICL1 promoter.	Peptichemio	103-106	isocitrate lyase 1	Saccharomyces cerevisiae S288C	124-128
9038161-9	1997	A consensus element with homology to the URS sequence of the ENO1 promoter was found in the promoters of the GPD1, GPP2, GCY1, and DAK1 genes.	Peptichemio	41-44	phosphopyruvate hydratase ENO1	Saccharomyces cerevisiae S288C	61-65
9368060-7	1997	The 57-bp URS contained not only Egr-1 consensus sequence (2) but also four direct repeats of a heptamer sequence (C/A)CAGCCC.	Peptichemio	10-13	early growth response 1	Mus musculus	33-38
9368060-8	1997	Electrophoresis mobility shift assay revealed that the 57-bp URS formed specific nuclear protein-DNA complexes, which were neither competed by previously known positive and negative vitamin D response elements nor supershifted by anti-vitamin D receptor antibody, suggesting the absence of vitamin D receptor in these complexes.	Peptichemio	61-64	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	235-253
9368060-8	1997	Electrophoresis mobility shift assay revealed that the 57-bp URS formed specific nuclear protein-DNA complexes, which were neither competed by previously known positive and negative vitamin D response elements nor supershifted by anti-vitamin D receptor antibody, suggesting the absence of vitamin D receptor in these complexes.	Peptichemio	61-64	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	290-308
9140049-4	1997	22Na+ uptake studies in PTC grown on permeable supports demonstrated preferential stimulation of apical vs. basolateral NHE.	Peptichemio	24-27	solute carrier family 9 member C1	Homo sapiens	120-123
9038161-9	1997	A consensus element with homology to the URS sequence of the ENO1 promoter was found in the promoters of the GPD1, GPP2, GCY1, and DAK1 genes.	Peptichemio	41-44	glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1	Saccharomyces cerevisiae S288C	109-113
9038161-9	1997	A consensus element with homology to the URS sequence of the ENO1 promoter was found in the promoters of the GPD1, GPP2, GCY1, and DAK1 genes.	Peptichemio	41-44	glycerol-1-phosphatase HOR2	Saccharomyces cerevisiae S288C	115-119
9038161-9	1997	A consensus element with homology to the URS sequence of the ENO1 promoter was found in the promoters of the GPD1, GPP2, GCY1, and DAK1 genes.	Peptichemio	41-44	glycerol 2-dehydrogenase (NADP(+)) GCY1	Saccharomyces cerevisiae S288C	121-125
9038161-9	1997	A consensus element with homology to the URS sequence of the ENO1 promoter was found in the promoters of the GPD1, GPP2, GCY1, and DAK1 genes.	Peptichemio	41-44	dihydroxyacetone kinase	Saccharomyces cerevisiae S288C	131-135
7700231-5	1995	Although a sequence mediating the control of gene expression by GCN4 was found within the URS element, the GCN4 gene product is not required for DNA-binding activity.	Peptichemio	90-93	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	64-68
9046094-4	1997	First, deletion of the URS(SUC2) results in expression of the SUC2 gene in the absence of glucose, and second the URS(SUC2) mediates a six-fold repression of a reporter gene when inserted into a heterologous promoter.	Peptichemio	23-26	beta-fructofuranosidase SUC2	Saccharomyces cerevisiae S288C	27-31
9046094-4	1997	First, deletion of the URS(SUC2) results in expression of the SUC2 gene in the absence of glucose, and second the URS(SUC2) mediates a six-fold repression of a reporter gene when inserted into a heterologous promoter.	Peptichemio	23-26	beta-fructofuranosidase SUC2	Saccharomyces cerevisiae S288C	62-66
9046094-4	1997	First, deletion of the URS(SUC2) results in expression of the SUC2 gene in the absence of glucose, and second the URS(SUC2) mediates a six-fold repression of a reporter gene when inserted into a heterologous promoter.	Peptichemio	23-26	beta-fructofuranosidase SUC2	Saccharomyces cerevisiae S288C	62-66
9046094-5	1997	However, this URS(SUC2) mediated repression occurs on all tested carbon sources, suggesting that this URS element acts in concert with all other promoter elements to respond to low concentrations of glucose.	Peptichemio	14-17	beta-fructofuranosidase SUC2	Saccharomyces cerevisiae S288C	18-22
9046094-5	1997	However, this URS(SUC2) mediated repression occurs on all tested carbon sources, suggesting that this URS element acts in concert with all other promoter elements to respond to low concentrations of glucose.	Peptichemio	102-105	beta-fructofuranosidase SUC2	Saccharomyces cerevisiae S288C	18-22
8668127-4	1996	Two elements, designated DRE1 and DRE2 (for damage-responsive element), match a decamer consensus URS (upstream repressing sequence) found in the promoters of many other DNA repair and metabolism genes from S. cerevisiae.	Peptichemio	98-101	electron carrier DRE2	Saccharomyces cerevisiae S288C	34-38
8668127-5	1996	However, our results show that DRE1 and DRE2 each function as a UAS (upstream activating sequence) rather than a URS and are also required for DNA-damage inducibility of the gene.	Peptichemio	113-116	electron carrier DRE2	Saccharomyces cerevisiae S288C	40-44
8668127-6	1996	A 20-bp fragment located downstream of both DRE1 and DRE2 is responsible for URS function.	Peptichemio	77-80	electron carrier DRE2	Saccharomyces cerevisiae S288C	53-57
8544396-5	1995	When the infusion rate was decreased to 15 +/- 3 nl/min, concomitant PTC infusion of NLA and 10(-7) M Ang II was associated with a tremendous increase in maximum TGF responses (23.8 +/- 3.9 mm Hg; P < 0.01 vs. responses during PTC NLA or Ang II) in the absence of a decrease in resting SFP.	Peptichemio	69-72	angiotensinogen	Homo sapiens	102-108
8544396-5	1995	When the infusion rate was decreased to 15 +/- 3 nl/min, concomitant PTC infusion of NLA and 10(-7) M Ang II was associated with a tremendous increase in maximum TGF responses (23.8 +/- 3.9 mm Hg; P < 0.01 vs. responses during PTC NLA or Ang II) in the absence of a decrease in resting SFP.	Peptichemio	69-72	angiotensinogen	Homo sapiens	241-247
7502579-3	1995	The ENO1 URS element repressed transcription of the yeast CYC1 gene when positioned between the CYC1 upstream activation sequences (UAS elements) and TATAAA boxes.	Peptichemio	9-12	phosphopyruvate hydratase ENO1	Saccharomyces cerevisiae S288C	4-8
7502579-3	1995	The ENO1 URS element repressed transcription of the yeast CYC1 gene when positioned between the CYC1 upstream activation sequences (UAS elements) and TATAAA boxes.	Peptichemio	9-12	cytochrome c isoform 1	Saccharomyces cerevisiae S288C	58-62
7502579-3	1995	The ENO1 URS element repressed transcription of the yeast CYC1 gene when positioned between the CYC1 upstream activation sequences (UAS elements) and TATAAA boxes.	Peptichemio	9-12	cytochrome c isoform 1	Saccharomyces cerevisiae S288C	96-100
7502579-4	1995	The ENO1 URS element failed to repress transcription of the wild-type yeast enolase gene ENO2; however, expression of an ENO2 gene lacking one of the ENO2 UAS elements was efficiently repressed by the ENO1 URS element, suggesting that the URS element interferes with the transcriptional activation by some, but not all, UAS elements.	Peptichemio	9-12	phosphopyruvate hydratase ENO1	Saccharomyces cerevisiae S288C	4-8
7502579-4	1995	The ENO1 URS element failed to repress transcription of the wild-type yeast enolase gene ENO2; however, expression of an ENO2 gene lacking one of the ENO2 UAS elements was efficiently repressed by the ENO1 URS element, suggesting that the URS element interferes with the transcriptional activation by some, but not all, UAS elements.	Peptichemio	9-12	phosphopyruvate hydratase ENO2	Saccharomyces cerevisiae S288C	121-125
7502579-4	1995	The ENO1 URS element failed to repress transcription of the wild-type yeast enolase gene ENO2; however, expression of an ENO2 gene lacking one of the ENO2 UAS elements was efficiently repressed by the ENO1 URS element, suggesting that the URS element interferes with the transcriptional activation by some, but not all, UAS elements.	Peptichemio	9-12	phosphopyruvate hydratase ENO2	Saccharomyces cerevisiae S288C	121-125
7502579-4	1995	The ENO1 URS element failed to repress transcription of the wild-type yeast enolase gene ENO2; however, expression of an ENO2 gene lacking one of the ENO2 UAS elements was efficiently repressed by the ENO1 URS element, suggesting that the URS element interferes with the transcriptional activation by some, but not all, UAS elements.	Peptichemio	206-209	phosphopyruvate hydratase ENO1	Saccharomyces cerevisiae S288C	4-8
7502579-4	1995	The ENO1 URS element failed to repress transcription of the wild-type yeast enolase gene ENO2; however, expression of an ENO2 gene lacking one of the ENO2 UAS elements was efficiently repressed by the ENO1 URS element, suggesting that the URS element interferes with the transcriptional activation by some, but not all, UAS elements.	Peptichemio	206-209	phosphopyruvate hydratase ENO2	Saccharomyces cerevisiae S288C	121-125
7502579-4	1995	The ENO1 URS element failed to repress transcription of the wild-type yeast enolase gene ENO2; however, expression of an ENO2 gene lacking one of the ENO2 UAS elements was efficiently repressed by the ENO1 URS element, suggesting that the URS element interferes with the transcriptional activation by some, but not all, UAS elements.	Peptichemio	206-209	phosphopyruvate hydratase ENO2	Saccharomyces cerevisiae S288C	121-125
7502579-4	1995	The ENO1 URS element failed to repress transcription of the wild-type yeast enolase gene ENO2; however, expression of an ENO2 gene lacking one of the ENO2 UAS elements was efficiently repressed by the ENO1 URS element, suggesting that the URS element interferes with the transcriptional activation by some, but not all, UAS elements.	Peptichemio	206-209	phosphopyruvate hydratase ENO1	Saccharomyces cerevisiae S288C	201-205
7502579-4	1995	The ENO1 URS element failed to repress transcription of the wild-type yeast enolase gene ENO2; however, expression of an ENO2 gene lacking one of the ENO2 UAS elements was efficiently repressed by the ENO1 URS element, suggesting that the URS element interferes with the transcriptional activation by some, but not all, UAS elements.	Peptichemio	206-209	phosphopyruvate hydratase ENO1	Saccharomyces cerevisiae S288C	4-8
7502579-4	1995	The ENO1 URS element failed to repress transcription of the wild-type yeast enolase gene ENO2; however, expression of an ENO2 gene lacking one of the ENO2 UAS elements was efficiently repressed by the ENO1 URS element, suggesting that the URS element interferes with the transcriptional activation by some, but not all, UAS elements.	Peptichemio	206-209	phosphopyruvate hydratase ENO2	Saccharomyces cerevisiae S288C	121-125
7502579-4	1995	The ENO1 URS element failed to repress transcription of the wild-type yeast enolase gene ENO2; however, expression of an ENO2 gene lacking one of the ENO2 UAS elements was efficiently repressed by the ENO1 URS element, suggesting that the URS element interferes with the transcriptional activation by some, but not all, UAS elements.	Peptichemio	206-209	phosphopyruvate hydratase ENO2	Saccharomyces cerevisiae S288C	121-125
7502579-4	1995	The ENO1 URS element failed to repress transcription of the wild-type yeast enolase gene ENO2; however, expression of an ENO2 gene lacking one of the ENO2 UAS elements was efficiently repressed by the ENO1 URS element, suggesting that the URS element interferes with the transcriptional activation by some, but not all, UAS elements.	Peptichemio	206-209	phosphopyruvate hydratase ENO1	Saccharomyces cerevisiae S288C	201-205
7502579-5	1995	In contrast to the ENO1 gene, the ENO1 URS element repressed CYC1 and ENO2 expression in cells grown on glucose or glycerol plus lactate.	Peptichemio	39-42	phosphopyruvate hydratase ENO1	Saccharomyces cerevisiae S288C	34-38
7502579-5	1995	In contrast to the ENO1 gene, the ENO1 URS element repressed CYC1 and ENO2 expression in cells grown on glucose or glycerol plus lactate.	Peptichemio	39-42	cytochrome c isoform 1	Saccharomyces cerevisiae S288C	61-65
7502579-5	1995	In contrast to the ENO1 gene, the ENO1 URS element repressed CYC1 and ENO2 expression in cells grown on glucose or glycerol plus lactate.	Peptichemio	39-42	phosphopyruvate hydratase ENO2	Saccharomyces cerevisiae S288C	70-74
7502579-6	1995	Evidence is presented that the ENO1 URS element also functions during stationary growth phase.	Peptichemio	36-39	phosphopyruvate hydratase ENO1	Saccharomyces cerevisiae S288C	31-35
9065690-4	1997	Ume6p, which also controls the expression of early meiotic genes, represses CAR1 expression through a sequence called URS, as a function of nitrogen availability.	Peptichemio	118-121	DNA-binding transcriptional regulator UME6	Saccharomyces cerevisiae S288C	0-5
9065690-4	1997	Ume6p, which also controls the expression of early meiotic genes, represses CAR1 expression through a sequence called URS, as a function of nitrogen availability.	Peptichemio	118-121	arginase	Saccharomyces cerevisiae S288C	76-80
9157248-8	1997	Like MAG1, the DDI1 gene is also controlled by an upstream repressing site (URS) located 5" to the direct repeat.	Peptichemio	76-79	DNA-3-methyladenine glycosylase II	Saccharomyces cerevisiae S288C	5-9
9157248-8	1997	Like MAG1, the DDI1 gene is also controlled by an upstream repressing site (URS) located 5" to the direct repeat.	Peptichemio	76-79	Ddi1p	Saccharomyces cerevisiae S288C	15-19
9157248-9	1997	Based on this and previous studies, a model is proposed whereby the constitutive expression of MAG1 and DDI1 is controlled by two functionally opposite regulatory elements, UAS and URS, probably through an antagonistic mechanism, whereas the damage-induced expression appears to be regulated by mechanisms of derepression at the URS as well as activation at the UAS.	Peptichemio	181-184	DNA-3-methyladenine glycosylase II	Saccharomyces cerevisiae S288C	95-99
9157248-9	1997	Based on this and previous studies, a model is proposed whereby the constitutive expression of MAG1 and DDI1 is controlled by two functionally opposite regulatory elements, UAS and URS, probably through an antagonistic mechanism, whereas the damage-induced expression appears to be regulated by mechanisms of derepression at the URS as well as activation at the UAS.	Peptichemio	181-184	Ddi1p	Saccharomyces cerevisiae S288C	104-108
9157248-9	1997	Based on this and previous studies, a model is proposed whereby the constitutive expression of MAG1 and DDI1 is controlled by two functionally opposite regulatory elements, UAS and URS, probably through an antagonistic mechanism, whereas the damage-induced expression appears to be regulated by mechanisms of derepression at the URS as well as activation at the UAS.	Peptichemio	329-332	DNA-3-methyladenine glycosylase II	Saccharomyces cerevisiae S288C	95-99
9157248-9	1997	Based on this and previous studies, a model is proposed whereby the constitutive expression of MAG1 and DDI1 is controlled by two functionally opposite regulatory elements, UAS and URS, probably through an antagonistic mechanism, whereas the damage-induced expression appears to be regulated by mechanisms of derepression at the URS as well as activation at the UAS.	Peptichemio	329-332	Ddi1p	Saccharomyces cerevisiae S288C	104-108
9266544-6	1996	The CD4+ to CD8+ T lymphocyte ratios (CD4+/CD8+ ratios) in the peripheral blood, spleen and thymus of URs were significantly smaller than in NRs; also, the ratios in the peripheral blood and spleen of URs were significantly smaller than in CRs.	Peptichemio	102-105	Cd4 molecule	Rattus norvegicus	4-7
9266544-6	1996	The CD4+ to CD8+ T lymphocyte ratios (CD4+/CD8+ ratios) in the peripheral blood, spleen and thymus of URs were significantly smaller than in NRs; also, the ratios in the peripheral blood and spleen of URs were significantly smaller than in CRs.	Peptichemio	102-105	Cd4 molecule	Rattus norvegicus	38-41
9266544-6	1996	The CD4+ to CD8+ T lymphocyte ratios (CD4+/CD8+ ratios) in the peripheral blood, spleen and thymus of URs were significantly smaller than in NRs; also, the ratios in the peripheral blood and spleen of URs were significantly smaller than in CRs.	Peptichemio	201-204	Cd4 molecule	Rattus norvegicus	38-41
7502579-1	1995	The activity of an upstream repression sequence (URS element) that mediates a 20-fold repression of ENO1 expression in cells grown in a medium containing glucose was characterized.	Peptichemio	49-52	phosphopyruvate hydratase ENO1	Saccharomyces cerevisiae S288C	100-104
7502579-2	1995	Sequences that are sufficient for orientation-dependent ENO1 URS element activity were mapped between positions -241 and -126 relative to the ENO1 transcriptional initiation site.	Peptichemio	61-64	phosphopyruvate hydratase ENO1	Saccharomyces cerevisiae S288C	56-60
7502579-2	1995	Sequences that are sufficient for orientation-dependent ENO1 URS element activity were mapped between positions -241 and -126 relative to the ENO1 transcriptional initiation site.	Peptichemio	61-64	phosphopyruvate hydratase ENO1	Saccharomyces cerevisiae S288C	142-146
7816617-6	1994	The upstream region of the HAC1 gene contains a T4C site, a URS (upstream repression sequence) and a TR (T-rich) box-like sequence, which reside upstream of many meiotic genes.	Peptichemio	60-63	transcription factor HAC1	Saccharomyces cerevisiae S288C	27-31
8144571-1	1994	Cis-acting sequences that modulate ENO1 URS (upstream repression site) element activity were identified by base pair substitution mutagenesis.	Peptichemio	40-43	phosphopyruvate hydratase ENO1	Saccharomyces cerevisiae S288C	35-39
8144571-4	1994	A binding site for the yeast REB1 protein was identified near the 5" terminus of the ENO1 URS element.	Peptichemio	90-93	DNA-binding protein REB1	Saccharomyces cerevisiae S288C	29-33
8144571-4	1994	A binding site for the yeast REB1 protein was identified near the 5" terminus of the ENO1 URS element.	Peptichemio	90-93	phosphopyruvate hydratase ENO1	Saccharomyces cerevisiae S288C	85-89
8144571-5	1994	Base substitution mutations that disrupted REB1 binding in vitro caused a 30% loss of URS activity in vivo.	Peptichemio	86-89	DNA-binding protein REB1	Saccharomyces cerevisiae S288C	43-47
8144571-8	1994	Base substitution mutations within a second region of the ENO1 URS element caused a 38% loss of URS activity in vivo.	Peptichemio	63-66	phosphopyruvate hydratase ENO1	Saccharomyces cerevisiae S288C	58-62
8144571-8	1994	Base substitution mutations within a second region of the ENO1 URS element caused a 38% loss of URS activity in vivo.	Peptichemio	96-99	phosphopyruvate hydratase ENO1	Saccharomyces cerevisiae S288C	58-62
8144571-9	1994	The nucleotide sequence of this latter region is very similar to essential sequences within the URS elements from the yeast CAR1 and SSA1 genes, respectively.	Peptichemio	96-99	arginase	Saccharomyces cerevisiae S288C	124-128
8144571-9	1994	The nucleotide sequence of this latter region is very similar to essential sequences within the URS elements from the yeast CAR1 and SSA1 genes, respectively.	Peptichemio	96-99	Hsp70 family ATPase SSA1	Saccharomyces cerevisiae S288C	133-137
8144571-10	1994	Base substitution mutations within a third region near the 3" terminus of the ENO1 URS element caused a 70% loss of URS activity in vivo.	Peptichemio	83-86	phosphopyruvate hydratase ENO1	Saccharomyces cerevisiae S288C	78-82
8144571-10	1994	Base substitution mutations within a third region near the 3" terminus of the ENO1 URS element caused a 70% loss of URS activity in vivo.	Peptichemio	116-119	phosphopyruvate hydratase ENO1	Saccharomyces cerevisiae S288C	78-82
8144571-12	1994	These results showed that ENO1 URS element activity was modulated by multiple cis-acting sequences that bound distinct trans-acting factors.	Peptichemio	31-34	phosphopyruvate hydratase ENO1	Saccharomyces cerevisiae S288C	26-30
8119960-8	1994	The protein interacts with two UAS1 13-base pair elements and one URS 13-base pair element, one of which had been previously designated GPE (general regulatory factor 1 (GRF1) binding site potentiator element) (Bitter, G. A., Chang, K. K. H., and Egan, K. M. (1991) Mol.	Peptichemio	66-69	DNA-binding transcription factor RAP1	Saccharomyces cerevisiae S288C	170-174
8119960-12	1994	In addition, mutational analyses strongly suggested that UAS1, URS, and UAS2 interact with GRF1 and GPEB, GPEB, and the GCR1 (glycolysis regulation 1) gene product, respectively.	Peptichemio	63-66	DNA-binding transcription factor RAP1	Saccharomyces cerevisiae S288C	91-95
1505479-3	1992	In URs from 14.5- and 15.5-day-old fetuses, the cranial portion of the MD regressed almost completely during the 3-day culture period in the presence of MIS, whereas the caudal half to third of the MD remained intact but tapered to a fine point cranially.	Peptichemio	3-6	anti-Mullerian hormone	Homo sapiens	153-156
8246943-5	1993	One of the MAG URS elements matches a decamer consensus sequence present in the promoters of 11 other S. cerevisiae DNA repair and metabolism genes, including the MGT1 gene, which encodes an O6-methylguanine DNA repair methyltransferase.	Peptichemio	15-18	methylated-DNA--protein-cysteine methyltransferase	Saccharomyces cerevisiae S288C	163-167
8246943-6	1993	Two proteins of 26 and 39 kDa bind specifically to the MAG and MGT1 URS elements.	Peptichemio	68-71	methylated-DNA--protein-cysteine methyltransferase	Saccharomyces cerevisiae S288C	63-67
8224185-4	1993	By deletion analyses as well as by studying the influence on expression of different fragments cloned into the heterologous CYC1 promoter lacking its own UAS sequences, we defined UAS and URS elements in the ICL1 promoter.	Peptichemio	188-191	isocitrate lyase 1	Saccharomyces cerevisiae S288C	208-212
8376332-9	1993	Since the DAL and UGA genes are overexpressed and largely inducer independent in dal80 deletion mutants, we have suggested DAL80 protein negatively regulates a wide spectrum of nitrogen-catabolic gene expression, likely in conjunction with a URS element.	Peptichemio	242-245	Dal80p	Saccharomyces cerevisiae S288C	123-128
2685561-3	1989	Deletion and subcloning analysis identified two, and possibly three, upstream activating sequences (UAS) and one repressing (URS) element in the RNR2 regulatory region.	Peptichemio	125-128	RNA, ribosomal 45S cluster 2	Homo sapiens	145-149
1901643-5	1991	We demonstrate that both the AP-1 sequence and the URS bind phorbol or interleukin-1 induced nuclear proteins.	Peptichemio	51-54	interleukin 1 alpha	Homo sapiens	71-84
34577533-4	2021	Herein, we developed tri-(tert-butanol)-methylammonium iodide (TBMA-I), a quaternary ammonium salt serving as the PTC for 18F-fluorination reactions.	Peptichemio	114-117	telomerase reverse transcriptase	Homo sapiens	26-30
1620097-4	1992	Dependence of activation on helical periodicity was observed in the region between the URS and the promoter of the xylS gene, suggesting DNA loop formation between these two sites, which are located about 100 bp apart.	Peptichemio	87-90	transcriptional activator of xyl-meta pathway operon	Pseudomonas putida	115-119
1620097-6	1992	This autogenous repression is decreased in an NtrA- background, irrespective of the presence of the xylS promoter in cis, indicating that NtrA protein, or NtrA-containing RNA polymerase that is not bound to the xylS promoter, is involved in the binding of XylR protein to the URS.	Peptichemio	276-279	xylose operon regulatory protein	Pseudomonas putida	256-260
2115115-3	1990	To determine the structure of the CAR1 URS element, we performed a saturation mutagenesis.	Peptichemio	39-42	arginase	Saccharomyces cerevisiae S288C	34-38
2115115-4	1990	Results of the mutagenic analysis indicated that the CAR1 URS was a 9-base-pair palindromic sequence, 5"-AGCCGCCGA-3".	Peptichemio	58-61	arginase	Saccharomyces cerevisiae S288C	53-57
2115115-8	1990	These sequences were shown to support varying degrees of URS function in the expression vector assay, to bind protein as demonstrated by the gel shift assay, and to compete with a DNA fragment containing the CAR1 URS for protein binding.	Peptichemio	57-60	arginase	Saccharomyces cerevisiae S288C	208-212
2115115-8	1990	These sequences were shown to support varying degrees of URS function in the expression vector assay, to bind protein as demonstrated by the gel shift assay, and to compete with a DNA fragment containing the CAR1 URS for protein binding.	Peptichemio	213-216	arginase	Saccharomyces cerevisiae S288C	208-212
2115115-9	1990	These results indicate that the CAR1 URS element possesses the characteristics of a repressor binding site.	Peptichemio	37-40	arginase	Saccharomyces cerevisiae S288C	32-36
2901386-9	1988	Thus, URS-2 plays a key role in the developmental regulation of Gapdh-2.	Peptichemio	6-9	Glyceraldehyde 3 phosphate dehydrogenase 2	Drosophila melanogaster	64-71
2656688-4	1989	The promoter element is located 5" to the URS in the ANB1 gene.	Peptichemio	42-45	translation elongation factor eIF-5A	Saccharomyces cerevisiae S288C	53-57
2901386-10	1988	Additionally, the efficient transcription of Gapdh-2 in larval and adult stages appears to depend on a synergistic function of URS-1 and URS-2.	Peptichemio	127-130	Glyceraldehyde 3 phosphate dehydrogenase 2	Drosophila melanogaster	45-52
2901386-10	1988	Additionally, the efficient transcription of Gapdh-2 in larval and adult stages appears to depend on a synergistic function of URS-1 and URS-2.	Peptichemio	137-140	Glyceraldehyde 3 phosphate dehydrogenase 2	Drosophila melanogaster	45-52
32726929-11	2020	Finally, we demonstrated that pretreatment of PTC-209 in mice bearing pemetrexed-resistant A549 tumors sensitized them to pemetrexed treatment and the expression of Ki-67, BMI1, and SP1 expression in tumor tissues was observed to be reduced.	Peptichemio	46-49	antigen identified by monoclonal antibody Ki 67	Mus musculus	165-170
3899417-7	1985	After sitting up the A-II concentration increased more in patients with URS than in those with EH (p less than 0.05).	Peptichemio	72-75	angiotensinogen	Homo sapiens	21-25
3295874-5	1987	Action of the URS and its cognate repressor was overcome by CAR1 induction when the URS was situated cis to the CAR1 flanking sequences.	Peptichemio	14-17	arginase	Saccharomyces cerevisiae S288C	60-64
3295874-5	1987	Action of the URS and its cognate repressor was overcome by CAR1 induction when the URS was situated cis to the CAR1 flanking sequences.	Peptichemio	14-17	arginase	Saccharomyces cerevisiae S288C	112-116
3295874-5	1987	Action of the URS and its cognate repressor was overcome by CAR1 induction when the URS was situated cis to the CAR1 flanking sequences.	Peptichemio	84-87	arginase	Saccharomyces cerevisiae S288C	60-64
3295874-5	1987	Action of the URS and its cognate repressor was overcome by CAR1 induction when the URS was situated cis to the CAR1 flanking sequences.	Peptichemio	84-87	arginase	Saccharomyces cerevisiae S288C	112-116
3295874-6	1987	This was not observed, however, when it was situated downstream of a heterologous CYC1 upstream activation sequence indicating that URS function is specifically neutralized by cis-acting elements associated with CAR1 induction.	Peptichemio	132-135	cytochrome c isoform 1	Saccharomyces cerevisiae S288C	82-86
3295874-6	1987	This was not observed, however, when it was situated downstream of a heterologous CYC1 upstream activation sequence indicating that URS function is specifically neutralized by cis-acting elements associated with CAR1 induction.	Peptichemio	132-135	arginase	Saccharomyces cerevisiae S288C	212-216
33080094-10	2021	CONCLUSIONS: The URS not only predicts the biochemical response, but also reflects the Nakanuma system and the CK7 hepatocyte grading at pretreatment.	Peptichemio	17-20	keratin 7	Homo sapiens	111-114
32674841-6	2020	The stage-to-stage match between URS biopsy/final pathology showed a positive predictive value (PPV) for cT1+/muscle-invasive disease of 94% (95% CI: 84%-100%) and a NPV for cTa-Tis/non-muscle-invasive disease of 60% (95% CI: 52%-68%).	Peptichemio	33-36	cardiotrophin 1	Homo sapiens	105-108
32674841-11	2020	The identification of cHG tumors and subepithelial connective tissue invasion (cT1+) in URS biopsy showed a moderate and a strong correlation with invasive UTUC, respectively.	Peptichemio	88-91	cardiotrophin 1	Homo sapiens	79-82
32726929-11	2020	Finally, we demonstrated that pretreatment of PTC-209 in mice bearing pemetrexed-resistant A549 tumors sensitized them to pemetrexed treatment and the expression of Ki-67, BMI1, and SP1 expression in tumor tissues was observed to be reduced.	Peptichemio	46-49	Bmi1 polycomb ring finger oncogene	Mus musculus	172-176
30797815-16	2019	Our findings suggest that iNOS plays a key role in the reduction of cardioprotection of PTC in diabetes and may provide a therapeutic target for diabetic patients.	Peptichemio	88-91	nitric oxide synthase 2	Homo sapiens	26-30
32278009-5	2020	Our results confirmed this hypothesis because: i) protection of PTC by DIDS was abolished by RAR-beta antagonist LE-135; ii) DIDS increased the expression of RAR-beta in PTC and prevented its decrease in cisplatin-treated PTC but not in cisplatin-treated human cervical adenocarcinoma HeLa cells in which DIDS failed to prevent cisplatin"s toxicity; iii) while RAR-beta expression decreased in cisplatin-treated PTC, RAR-beta over-expression prevented cisplatin"s toxicity.	Peptichemio	64-67	retinoic acid receptor alpha	Homo sapiens	93-101
32080691-3	2020	Compared with the URS intervention group, the ARS administration resulted in a more pronounced effect in controlling body weight, together with a more prominent reduction in blood glucose and triglyceride concentration, as well as a significant increase in the HDL-c level in obese mice.	Peptichemio	18-21	secreted Ly6/Plaur domain containing 1	Mus musculus	46-49
32080691-4	2020	The ARS group also showed an absolute advantage over URS in suppressing the oxidative stress and regulating the liver function induced by the HF diet.	Peptichemio	53-56	secreted Ly6/Plaur domain containing 1	Mus musculus	4-7
32080691-5	2020	Simultaneously, the administration of URS and ARS efficiently suppressed the HF-diet induced alterations in gut microbial ecology, with an obviously decreased ratio of Firmicutes to Bacteroidetes, especially for the ARS group, suggesting its beneficial role in gastrointestinal tract health.	Peptichemio	38-41	secreted Ly6/Plaur domain containing 1	Mus musculus	216-219
32080691-6	2020	The structural characterization results revealed that ARS and URS differed significantly in their supramolecular structural characteristics, where ARS exhibited a higher proportion of crystallinity and double helix content with an X-ray diffraction pattern of a CB type crystal polymorph and a low proportion of molecular inhomogeneity.	Peptichemio	62-65	secreted Ly6/Plaur domain containing 1	Mus musculus	147-150
31054579-6	2019	On E15, abundant stained cells were observed in the rectum, URS and dorsal cloacal membrane and the expression of positive cells reached its peak.	Peptichemio	60-63	RNA, U105C small nucleolar	Homo sapiens	3-6
30268882-5	2018	RESULTS: Immunohistochemical staining of ARM embryos revealed that MSX2 was mainly expressed in the epithelium of the hindgut and urorectal septum (URS) on GD14.	Peptichemio	148-151	msh homeobox 2	Rattus norvegicus	67-71
30268882-7	2018	However, in normal embryos, faint immunopositivity for MSX2 was demonstrated in the epithelium of the rectum and URS from GD14 to GD16.	Peptichemio	113-116	msh homeobox 2	Rattus norvegicus	55-59
30527251-7	2018	Comparing TNM-7 and TNM-8, the PVE values increased from 3.4% to 4.7% in the PTC group, whereas they decreased from 17.5% to 14.5% in the FTC group.	Peptichemio	77-80	teneurin transmembrane protein 1	Homo sapiens	20-23
27941910-7	2016	We found that the URs of [123I]-ADAM were significantly lower in the brains of MDMA than control group, indicating lower brain SERT levels in the MDMA-treated monkeys.	Peptichemio	18-21	solute carrier family 6 member 4	Homo sapiens	127-131
28593477-9	2017	When comparing the two time periods, during period 2, the change was +171% (p = 0.007), +279% (p < 0.001), and -17% (p = 0.2) for URS, PCNL, and SWL, respectively.	Peptichemio	133-136	period circadian regulator 2	Homo sapiens	44-52
29262596-4	2017	Herein, we report on the anti-myeloma effects of the BMI-1 inhibitor PTC-209 and demonstrate that PTC-209 is a potent anti-myeloma agent in vitro using MM cell lines and primary MM cells.	Peptichemio	69-72	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	53-58
28848992-5	2017	The mechanism of action of URS against MRSA was analyzed using a viability assay in the presence of a detergent and an ATPase inhibitor.	Peptichemio	27-30	AT695_RS06370	Staphylococcus aureus	119-125
28363010-10	2017	Sequences with similarity to the AP2 gene were isolated from the oat lines UFRGS 017004-2 and URS Taura, and genetic polymorphisms were identified, which are valuable to confirm the action of AP2 on the multiflorous spikelet trait.	Peptichemio	94-97	transcription factor AP-2 alpha	Homo sapiens	33-36