PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
19005028-10	2009	Therefore, the presence of a nitro group in the side chain of benzodiazepines may play a crucial role in the metabolic activation by CYP3A4.	nitro	29-34	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	133-139
18393299-7	2009	In RAN-B polymorphs, the nitro group is involved in a strong intramolecular hydrogen bond responsible for the existence of a Z configuration in the enamine portion of the molecules.	nitro	25-30	RAN, member RAS oncogene family	Homo sapiens	3-6
19396848-2	2009	The nitro precursor is reduced at the tip to the amine, which is diazotized in the interelectrode space as it diffuses (see picture).	nitro	4-9	TOR signaling pathway regulator	Homo sapiens	38-41
19022677-5	2009	The results suggest that this heterocyclic functionality is potential bioisoster of the nitro and cyano groups forming the polar pharmacophores of known non-steroidal AR ligands.	nitro	88-93	androgen receptor	Homo sapiens	167-169
19152223-3	2009	The major activation pathway of AA involves reduction of the nitro group, primarily catalyzed by NAD(P)H:quinone oxidoreductase (NQO1), to an electrophilic cyclic N-acylnitrenium ion that reacts preferentially with purine bases to form covalent DNA adducts.	nitro	61-66	NAD(P)H quinone dehydrogenase 1	Homo sapiens	129-133
19026174-7	2008	CONCLUSION: This study was the first to identify new structural types of antiproliferative agents against the EGFR-overexpressing tumor cell lines by the incorporation of the nitro group at the 3-position of the quinoline core structure, providing promising new templates for the further development of anticancer agents.	nitro	175-180	epidermal growth factor receptor	Homo sapiens	110-114
18614806-9	2008	RESULTS: Pretreatment with blebbistatin (5 microM for 20 minutes) or its nitro derivative prevented the thrombin-induced inhibition of the Ca(2+) wave.	nitro	73-78	coagulation factor II, thrombin	Bos taurus	104-112
26631704-6	2008	In addition, according to the experimentally detected enhancement of the reaction rate due to the presence of a nitro group on the benzoate ligand, our calculations show that the transition state for the hydrogen atom abstraction by molecular oxygen along the pathway for the oxygenation reaction of (IMe)2(p-O2NC6H4CO2)PdH lies lower in energy with respect to the analogous transition state calculated for R=Ph.	nitro	112-117	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	320-323
18289860-5	2008	7-NO(2)-1,2,3,4-Tetrahydroisoquino-2-yl purine riboside was identified as the analogue with the nitro group in the best orientation at the NBMPR binding site of ENT1.	nitro	96-101	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	161-165
18589954-4	2008	The transient appearance of 1,3-dinitro-5-nitroso-1,3,5-triazacyclohexane (MNX), 1,3-dinitroso-5-nitro-1,3,5-triazacyclohexane (DNX), and 1,3,5-trinitroso-1,3,5-triazacyclohexane (TNX) indicate that some nitro-group reduction occurred.	nitro	34-39	keratin 86	Homo sapiens	75-78
18289863-0	2008	Nitro as a novel zinc-binding group in the inhibition of carboxypeptidase A.	nitro	0-5	carboxypeptidase A1	Homo sapiens	57-75
18572893-5	2008	CIS/6-31G(d,p) calculations predict planarization of the nitro-aromatic torsional angle as the major nuclear relaxation coordinate, from 32.8 degrees at the HF/6-31G(d,p) level of theory in the ground state (27.46 degrees at B3LYP/6-31++G(d,p)) to 0.07 degrees in the S1 state.	nitro	57-62	suppressor of cytokine signaling 5	Homo sapiens	0-5
18196976-0	2008	NCX-4016, a nitro-derivative of aspirin, inhibits EGFR and STAT3 signaling and modulates Bcl-2 proteins in cisplatin-resistant human ovarian cancer cells and xenografts.	nitro	12-17	T cell leukemia homeobox 2	Homo sapiens	0-3
18207300-8	2008	AKR1C2 was constitutively expressed in HepG2 cells and was not regulated by 1-NP or B[a]P. In conclusion, this is the first report on AKRs" actions toward nitro-PAH in cells.	nitro	155-160	aldo-keto reductase family 1 member C2	Homo sapiens	0-6
17983755-6	2008	Differences in the way carnitine nitro-derivatives are metabolized in biological fluids and cells and transported by OCTN2 transporter are modulated by the chemical structures and by the length of the acyl template which carries the nitro-group.	nitro	33-38	solute carrier family 22 member 5	Homo sapiens	117-122
18289863-3	2008	X-ray crystallography discloses that the nitro group well mimics the transition state occurred in the hydrolysis catalyzed by CPA, that is, an O,O"-bidentate coordination to the zinc ion and the two respective hydrogen bonds with Glu-270 and Arg-127.	nitro	41-46	carboxypeptidase A1	Homo sapiens	126-129
18289863-4	2008	Because the nitro group is a planar species, we proposed (R)-2-benzyl-3-nitropropanoic acid as a pseudo-transition-state analog inhibitor against CPA.	nitro	12-17	carboxypeptidase A1	Homo sapiens	146-149
18194265-6	2008	Strikingly, iNOS-/- and Nitro-Arg-treated mice presented fungal resistance, controlling fungal load in tissues and restoring T-cell activity, as well as producing high amounts of IFN-gamma Interestingly, macrophages from these groups of mice presented fungicidal activity after in vitro stimulation with higher doses of IFN-gamma.	nitro	24-29	interferon gamma	Mus musculus	179-188
18194265-6	2008	Strikingly, iNOS-/- and Nitro-Arg-treated mice presented fungal resistance, controlling fungal load in tissues and restoring T-cell activity, as well as producing high amounts of IFN-gamma Interestingly, macrophages from these groups of mice presented fungicidal activity after in vitro stimulation with higher doses of IFN-gamma.	nitro	24-29	interferon gamma	Mus musculus	320-329
18161731-9	2008	Furthermore, hemoglobin also catalyzed nitro reduction of 3-nitrotyrosine to form 3-aminotyrosine, at Tyr24 in the alpha-chain peptide of human Hb in the presence of ascorbate.	nitro	39-44	Fc gamma receptor and transporter	Homo sapiens	115-126
18196976-1	2008	We have previously reported the inhibitory effect of NCX-4016, a nitro derivative of aspirin, on the proliferation of cisplatin-resistant human ovarian cancer cells, in vitro (Bratasz et al., Proc Natl Acad Sci USA 2006; 103:3914-9).	nitro	65-70	T cell leukemia homeobox 2	Homo sapiens	53-56
17643990-2	2007	Molecular modelling studies suggest that cryptolepine is able to fit into the active site of NQO2 and thus raising the possibility that nitro-analogues of 1 could act as bioreductive prodrugs and be selectively reduced by NQO1 and NQO2 to more toxic species in cancer cells in which these enzymes are over-expressed.	nitro	136-141	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	93-97
18554544-3	2008	A novel structural modification, involving the addition of nitro and hydroxy groups to tryptophan, has been detected in the mitochondrial protein succinyl-CoA:3-oxoacid CoA transferase (SCOT) in rat heart.	nitro	59-64	3-oxoacid CoA transferase 1	Rattus norvegicus	146-184
18554544-3	2008	A novel structural modification, involving the addition of nitro and hydroxy groups to tryptophan, has been detected in the mitochondrial protein succinyl-CoA:3-oxoacid CoA transferase (SCOT) in rat heart.	nitro	59-64	3-oxoacid CoA transferase 1	Rattus norvegicus	186-190
17880238-1	2007	A general synthetic route to prepare derivatives of the DEPMPO nitrone (5-diethoxyphosphoryl-5-methyl-1-pyrroline-N-oxide) functionalized at C-4 was established via the synthesis of 4-HMDEPMPO nitrone (5-diethoxyphosphoryl-4-hydroxymethyl-5-methyl-1-pyrroline-N-oxide) that was obtained from reduction of the nitro compound 1.	nitro	63-68	complement C4A (Rodgers blood group)	Homo sapiens	141-144
17760507-1	2007	We recently reported that NCX-4016, a derivative of aspirin containing a nitro moiety that releases nitric oxide (NO) in a sustained fashion in biologic systems, is a potent cytotoxic agent inhibiting the proliferation of cisplatin-resistant human ovarian cancer cells.	nitro	73-78	T cell leukemia homeobox 2	Homo sapiens	26-29
17643990-2	2007	Molecular modelling studies suggest that cryptolepine is able to fit into the active site of NQO2 and thus raising the possibility that nitro-analogues of 1 could act as bioreductive prodrugs and be selectively reduced by NQO1 and NQO2 to more toxic species in cancer cells in which these enzymes are over-expressed.	nitro	136-141	NAD(P)H quinone dehydrogenase 1	Homo sapiens	222-226
17643990-2	2007	Molecular modelling studies suggest that cryptolepine is able to fit into the active site of NQO2 and thus raising the possibility that nitro-analogues of 1 could act as bioreductive prodrugs and be selectively reduced by NQO1 and NQO2 to more toxic species in cancer cells in which these enzymes are over-expressed.	nitro	136-141	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	231-235
17510231-6	2007	The increase in nitro-JAK2 after LPS was greater in a line of experimental animals with a genetic propensity for higher PR at the given LPS dose than responses measured in their normal counterparts.	nitro	16-21	Janus kinase 2	Homo sapiens	22-26
17510231-7	2007	The development and remission of nitro-JAK2 was temporally concordant with changes in plasma concentrations of IGF-I; hepatocellular IGF-I mRNA content was inversely proportional to nitro-JAK2 content.	nitro	33-38	Janus kinase 2	Homo sapiens	39-43
17510231-7	2007	The development and remission of nitro-JAK2 was temporally concordant with changes in plasma concentrations of IGF-I; hepatocellular IGF-I mRNA content was inversely proportional to nitro-JAK2 content.	nitro	33-38	insulin like growth factor 1	Homo sapiens	111-116
17510232-4	2007	In vivo (bovine liver) and in vitro (porcine hepatocytes), GH-induced cellular levels of nitro-(1007)Y-(1008)Y-JAK2 persisted significantly longer after a stimulatory GH pulse than did levels of phospho-JAK2.	nitro	89-94	Janus kinase 2	Bos taurus	111-115
17510232-4	2007	In vivo (bovine liver) and in vitro (porcine hepatocytes), GH-induced cellular levels of nitro-(1007)Y-(1008)Y-JAK2 persisted significantly longer after a stimulatory GH pulse than did levels of phospho-JAK2.	nitro	89-94	Janus kinase 2	Bos taurus	203-207
17510232-5	2007	Treatment of cultured cells with inhibitors of AKT or endothelial nitric oxide synthase prior to GH challenge attenuated the increases in nitro-JAK2 predominantly in the membrane subcellular fraction.	nitro	138-143	AKT serine/threonine kinase 1	Bos taurus	47-50
17510232-5	2007	Treatment of cultured cells with inhibitors of AKT or endothelial nitric oxide synthase prior to GH challenge attenuated the increases in nitro-JAK2 predominantly in the membrane subcellular fraction.	nitro	138-143	nitric oxide synthase 3	Bos taurus	54-87
17510232-5	2007	Treatment of cultured cells with inhibitors of AKT or endothelial nitric oxide synthase prior to GH challenge attenuated the increases in nitro-JAK2 predominantly in the membrane subcellular fraction.	nitro	138-143	Janus kinase 2	Bos taurus	144-148
17909483-0	2007	Synthesis of novel nitro-substituted triaryl pyrazole derivatives as potential estrogen receptor ligands.	nitro	19-24	estrogen receptor 1	Homo sapiens	79-96
17909483-1	2007	Novel tetrasubstituted pyrazole derivatives bearing a nitro substituent on their A-phenol ring were synthesized and their binding affinity towards the estrogen receptor (ER) subtypes ERalpha and ERbeta was determined.	nitro	54-59	estrogen receptor 1	Homo sapiens	151-168
17909483-1	2007	Novel tetrasubstituted pyrazole derivatives bearing a nitro substituent on their A-phenol ring were synthesized and their binding affinity towards the estrogen receptor (ER) subtypes ERalpha and ERbeta was determined.	nitro	54-59	estrogen receptor 2	Homo sapiens	195-201
17909483-3	2007	In general, the introduction of a nitro group into the A ring of these compounds was found to benefit their ERbeta binding abilities.	nitro	34-39	estrogen receptor 2	Homo sapiens	108-114
17083258-7	2006	Reaction of the nitro complexes with HPF6 gives the new nitrosyl complexes [Ru(bpy)TpNO][PF6]2 and [Ru(bpy)(Tpm)NO][PF6]3.	nitro	16-21	sperm associated antigen 17	Homo sapiens	38-41
17258463-3	2007	Several substituents including an oxygen anion, amino, and nitro groups have been introduced at the C-6 position of the indazole scaffold, leading to a significant drop in Akt potency.	nitro	59-64	AKT serine/threonine kinase 1	Homo sapiens	172-175
17083258-7	2006	Reaction of the nitro complexes with HPF6 gives the new nitrosyl complexes [Ru(bpy)TpNO][PF6]2 and [Ru(bpy)(Tpm)NO][PF6]3.	nitro	16-21	sperm associated antigen 17	Homo sapiens	89-92
17083258-9	2006	The nitro and nitrosyl complexes were characterized by 1H and 15N NMR and IR spectroscopy, elemental analysis, cyclic voltammetry, and single-crystal structure determination for [Ru(bpy)TpNO][PF6]2.	nitro	4-9	sperm associated antigen 17	Homo sapiens	192-195
16442292-1	2006	A series of analogs with nitro or serinamide substituents at the C-2"-, C-5"-, or C-6"-position of the combretastatin A-4 (CA4) B-ring was synthesized and evaluated for cytotoxic effects against heart endothelioma cells, blood flow reduction to tumors in SCID mice, and as inhibitors of tubulin polymerization.	nitro	25-30	carbonic anhydrase 4	Mus musculus	103-121
16815963-9	2006	Species differences were observed in S-4 metabolism; the major metabolic pathway for S-4 in dogs was deacetylation of the B-ring acetamide group and reduction of the A-ring nitro group, whereas the major metabolic pathway for S-4 in rats was hydrolysis on the amide bond and reduction of the A-ring nitro group.	nitro	173-178	proteasome 26S subunit, ATPase 1	Rattus norvegicus	85-88
16815963-9	2006	Species differences were observed in S-4 metabolism; the major metabolic pathway for S-4 in dogs was deacetylation of the B-ring acetamide group and reduction of the A-ring nitro group, whereas the major metabolic pathway for S-4 in rats was hydrolysis on the amide bond and reduction of the A-ring nitro group.	nitro	173-178	proteasome 26S subunit, ATPase 1	Rattus norvegicus	85-88
16815963-9	2006	Species differences were observed in S-4 metabolism; the major metabolic pathway for S-4 in dogs was deacetylation of the B-ring acetamide group and reduction of the A-ring nitro group, whereas the major metabolic pathway for S-4 in rats was hydrolysis on the amide bond and reduction of the A-ring nitro group.	nitro	299-304	proteasome 26S subunit, ATPase 1	Rattus norvegicus	85-88
16815963-9	2006	Species differences were observed in S-4 metabolism; the major metabolic pathway for S-4 in dogs was deacetylation of the B-ring acetamide group and reduction of the A-ring nitro group, whereas the major metabolic pathway for S-4 in rats was hydrolysis on the amide bond and reduction of the A-ring nitro group.	nitro	299-304	proteasome 26S subunit, ATPase 1	Rattus norvegicus	85-88
16904722-11	2006	Nitro-group of PNP converted to nitrite and nitrate.	nitro	0-5	purine nucleoside phosphorylase	Homo sapiens	15-18
16676969-6	2006	IR spectral changes show that, upon further warming to 200 K, 2 isomerizes into the N-bonded nitro linkage isomer Mn(Por)(NO)(NO2) (3).	nitro	93-98	cytochrome p450 oxidoreductase	Homo sapiens	117-120
16894785-4	2006	Among the substituents on the benzoyl group of analytes, the nitro group was the best for good resolution of analytes on CSP 1.	nitro	61-66	regulator of calcineurin 1	Homo sapiens	121-126
16618795-3	2006	For this purpose, we compared two simple regioisomeric nitrocatechol-type inhibitors of COMT, BIA 3-228 and BIA 8-176, which contain the benzoyl substituent attached at the meta and ortho positions, respectively, relative to the nitro group.	nitro	55-60	catechol-O-methyltransferase	Homo sapiens	88-92
16618795-7	2006	This is the first reported structure of the soluble form of COMT complexed with a nitrocatecholic inhibitor having a bulky substituent group in adjacent position (ortho) to the nitro group.	nitro	82-87	catechol-O-methyltransferase	Homo sapiens	60-64
16442292-3	2006	Several of these nitrogen-modified CA4 derivatives (both amino and nitro) demonstrate significant inhibition of tubulin assembly as well as cytotoxicity and in vivo blood flow reduction.	nitro	17-22	carbonic anhydrase 4	Mus musculus	35-38
16272404-3	2006	The major phase I metabolism pathways of S4 in humans were identified as deacetylation of the B-ring acetamide group, hydrolysis of the amide bond, reduction of the A-ring nitro group, and oxidation of the aromatic rings, with deacetylation being the predominant pathway observed with most of the enzyme preparations tested.	nitro	172-177	ribosomal protein S4 X-linked	Homo sapiens	41-43
16702728-3	2006	The liver cytosol of various mammals also exhibits a significant reductase activity toward nitro, sulfoxide, N-oxide and other moieties, catalyzed by aldehyde oxidase.	nitro	91-96	aldehyde oxidase 1	Homo sapiens	150-166
16153789-2	2006	CYP3A4 oxidation at several molecular sites and AOX reduction at the nitro substituent result in either an increase (activation) or decrease (inactivation) of agonist potency at nicotinic acetylcholine receptors (nAChRs), both insect and vertebrate alpha 4beta 2.	nitro	69-74	Aldox89A	Drosophila melanogaster	48-51
16497833-0	2006	Reversal to cisplatin sensitivity in recurrent human ovarian cancer cells by NCX-4016, a nitro derivative of aspirin.	nitro	89-94	T cell leukemia homeobox 2	Homo sapiens	77-80
16497833-5	2006	We used NCX-4016 [2-(acetyloxy)benzoic acid 3-(nitrooxymethyl)phenyl ester], a derivative of aspirin containing a nitro group that releases nitric oxide in a sustained fashion for several hours in cells and in vivo, and we studied its cytotoxic efficacy against human ovarian cancer cells (HOCCs).	nitro	47-52	T cell leukemia homeobox 2	Homo sapiens	8-11
16392842-7	2006	The geometrical distortions of the BaP structure upon nitro group substitution and correlations between structural parameters and vibrational data as well as structure-function relationships related to the mutagenicity of this important class of polycyclic aromatic hydrocarbons are discussed.	nitro	54-59	prohibitin 2	Homo sapiens	35-38
16129418-4	2005	The complex structure indicates the essentiality of the two nitro groups: one nitro group forms hydrogen bonds with the side-chain of Asn161 of QR2 to hold the other nitro group in position for the reduction.	nitro	60-65	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	144-147
16335931-2	2005	Changing the position of the nitro group from the "classical" meta- to the ortho-position relative to the side-chain substituent of the nitrocatechol pharmacophore exerted profound effects on selectivity and duration of COMT inhibition.	nitro	29-34	catechol-O-methyltransferase	Homo sapiens	220-224
16125300-9	2005	The orientation of AAI in the active centre of CYP1A1 however causes an interaction of the heme iron with both the nitro- and the carboxylic groups of AAI.	nitro	115-120	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	47-53
16129418-4	2005	The complex structure indicates the essentiality of the two nitro groups: one nitro group forms hydrogen bonds with the side-chain of Asn161 of QR2 to hold the other nitro group in position for the reduction.	nitro	78-83	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	144-147
16129418-4	2005	The complex structure indicates the essentiality of the two nitro groups: one nitro group forms hydrogen bonds with the side-chain of Asn161 of QR2 to hold the other nitro group in position for the reduction.	nitro	78-83	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	144-147
15681708-9	2005	The results suggest that nitro generation activated MMP and PAR-1, leading to endothelial-myocyte uncoupling.	nitro	25-30	matrix metallopeptidase 2	Mus musculus	52-55
15996858-6	2005	Both nitro-derivatives were found to alter the phosphorylation status of ERK1/ERK2 and p38.	nitro	5-10	mitogen-activated protein kinase 3	Homo sapiens	73-77
15996858-6	2005	Both nitro-derivatives were found to alter the phosphorylation status of ERK1/ERK2 and p38.	nitro	5-10	mitogen-activated protein kinase 1	Homo sapiens	78-82
15996858-6	2005	Both nitro-derivatives were found to alter the phosphorylation status of ERK1/ERK2 and p38.	nitro	5-10	mitogen-activated protein kinase 1	Homo sapiens	87-90
15996858-11	2005	Also, the MEK inhibitor (PD98059) in combination with nitro-derivatives stimulated an even greater increase in tyrosinase activity when compared to either drug.	nitro	54-59	mitogen-activated protein kinase kinase 7	Homo sapiens	10-13
15996858-11	2005	Also, the MEK inhibitor (PD98059) in combination with nitro-derivatives stimulated an even greater increase in tyrosinase activity when compared to either drug.	nitro	54-59	tyrosinase	Homo sapiens	111-121
15911322-4	2005	Structure-activity relationships showed that the position (ortho or meta) of the nitro-substituent on the C-5 phenyl ring, the size (van der Waal"s radius for Br and Cl are 1.95 and 1.80A, respectively) and/or electronegativity (Cl>Br) of the C-7 geminal halogen atoms do not appear to have a significant effect on CC antagonist activity.	nitro	81-86	complement C5	Cavia porcellus	106-109
15911322-4	2005	Structure-activity relationships showed that the position (ortho or meta) of the nitro-substituent on the C-5 phenyl ring, the size (van der Waal"s radius for Br and Cl are 1.95 and 1.80A, respectively) and/or electronegativity (Cl>Br) of the C-7 geminal halogen atoms do not appear to have a significant effect on CC antagonist activity.	nitro	81-86	complement component C7	Cavia porcellus	246-249
16097830-2	2005	Stepwise conversion of the chloro complex [Ru(tpy)(dpk)(Cl)]+ ([1]+) via [Ru(tpy)(dpk)(CH3CN)]2+ ([2]2+) and the nitro compound [Ru(tpy)(dpk)(NO2)]+ ([3]+) yielded [4]3+; all four complexes were structurally characterized as perchlorates.	nitro	113-118	TAO kinase 3	Homo sapiens	82-85
16097830-2	2005	Stepwise conversion of the chloro complex [Ru(tpy)(dpk)(Cl)]+ ([1]+) via [Ru(tpy)(dpk)(CH3CN)]2+ ([2]2+) and the nitro compound [Ru(tpy)(dpk)(NO2)]+ ([3]+) yielded [4]3+; all four complexes were structurally characterized as perchlorates.	nitro	113-118	TAO kinase 3	Homo sapiens	82-85
15925323-2	2005	We estimated CFTR Cl(-) channel activity and transcellular Cl(-) secretion by measuring 5-nitro 2-(3-phenylpropylamino)benzoate (NPPB, a blocker of CFTR Cl(-) channel)-sensitive transepithelial conductance (Gt) and short-circuit current (Isc), respectively.	nitro	90-95	CF transmembrane conductance regulator	Homo sapiens	13-17
15681708-9	2005	The results suggest that nitro generation activated MMP and PAR-1, leading to endothelial-myocyte uncoupling.	nitro	25-30	coagulation factor II (thrombin) receptor	Mus musculus	60-65
15651034-4	2005	The two methods are then used to evaluate the accuracy of different popular post-SCF methods (B3LYP and MP2) and molecular mechanics methods (MMX and MMFF94) in calculating the molecular structure of a set of sterically crowded nitro aromatic compounds.	nitro	228-233	tryptase pseudogene 1	Homo sapiens	104-107
15804809-3	2005	Likely degradation mechanisms for hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) include hydroxylation utilizing addition of hydroxide ions to initiate proton abstraction via 2nd order rate elimination (E2) or via nucleophilic substitution of nitro groups, reductive chemical and biochemical degradation, and free radical oxidation.	nitro	53-58	radixin	Homo sapiens	75-78
15331172-8	2004	Finally, the two nitro-derivatives caused a dose-dependant inhibition of the S phase regulatory protein, cyclin A.	nitro	17-22	cyclin A2	Homo sapiens	105-113
15704952-2	2005	A remarkably regioselective hexa ipso-nitration reaction led to a calix[6]azatube substituted at the wide rim in alternate position by tBu and nitro groups.	nitro	143-148	hexosaminidase subunit alpha	Homo sapiens	28-32
15147783-4	2004	QSDs bind covalently to bovine serum albumin (BSA) under anaerobic conditions, in the presence, and less in the absence, of HX/XO and only if the nitro group is present at the QSD.	nitro	146-151	albumin	Homo sapiens	31-44
15368579-0	2004	Bisubstrate inhibitors of the enzyme catechol O-methyltransferase (COMT): efficient inhibition despite the lack of a nitro group.	nitro	117-122	catechol-O-methyltransferase	Homo sapiens	37-65
15368579-0	2004	Bisubstrate inhibitors of the enzyme catechol O-methyltransferase (COMT): efficient inhibition despite the lack of a nitro group.	nitro	117-122	catechol-O-methyltransferase	Homo sapiens	67-71
15288124-6	2004	A myeloperoxidase-H(2)O(2)-NO(2)(-) system generated the nitro derivatives but not the nitroso derivative.	nitro	57-62	myeloperoxidase	Homo sapiens	2-17
15179450-10	2004	The finding of increased liver nitrite/nitrate content in NCX-1000-treated animals together with an increase in cGMP levels in their liver homogenates suggests that this nitro-compound behaves as a liver-selective NO donor.	nitro	170-175	T cell leukemia homeobox 2	Homo sapiens	58-61
15206865-6	2004	A rationale for the catalysis invokes the highly reduced Fe(I) state of myoglobin in surfactant film; the latter engages in efficient inner-sphere electron transfers to the nitro compound coupled to proton transfers.	nitro	173-178	myoglobin	Homo sapiens	72-81
15038757-8	2004	Both V(TH) and beta of the nitro-based SAMs also depended strongly on the molecular headgroup on the end benzene ring addressed by the tip.	nitro	27-32	TOR signaling pathway regulator	Homo sapiens	135-138
15187443-5	2004	The present findings suggest that the ability of dihydropyridine calcium channel antagonists to activate the CYP2B1 and CYP3A1 are mainly dependent on the length of the side chain at the 3-position of the dihydropyridine ring and the position of the nitro group in the nitrophenyl substituent, respectively.	nitro	250-255	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	109-115
15187443-5	2004	The present findings suggest that the ability of dihydropyridine calcium channel antagonists to activate the CYP2B1 and CYP3A1 are mainly dependent on the length of the side chain at the 3-position of the dihydropyridine ring and the position of the nitro group in the nitrophenyl substituent, respectively.	nitro	250-255	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	120-126
14658904-1	2003	Interaction of a low-pressure NO2 with sublimed layers of (meso-tetraphenylporphyrinato)cobalt(II) (Co(TPP)) leads to formation of 5-coordinate nitro complex Co(III)(TPP)(NO2).	nitro	144-149	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	158-165
14672753-4	2004	This is exemplified by aristolochic acids present in Aristolochia spp, undergoing reduction of the nitro group by hepatic cytochrome P450 (CYP1A1/2) or peroxidases in extrahepatic tissues to reactive cyclic nitrenium ion.	nitro	99-104	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	139-145
15001841-4	2004	Docking of this molecule onto the P-selectin carbohydrate-binding site demonstrated that a nitro group enabled an electrostatic interaction with residue Lys 84, while the phenyl ring and the CH2 at C-6 contacted the CH2 groups of the same Lys residue.	nitro	91-96	selectin P	Homo sapiens	34-44
14737322-3	2004	The fragment ion of m/z 149 from RDX reacts with EVE by a formal vinylation reaction, that is, the elusive cyclic adduct loses ethanol to yield a nitro-iminium ion of m/z 175, which reacts further with EVE to form a second cyclic product ion of m/z 247.	nitro	146-151	radixin	Homo sapiens	33-36
14575878-1	2003	The nitro group of a neonicotinoid, imidacloprid, plays a key role in its selective actions on insect nicotinic acetylcholine receptors (nicotinic AChRs) and is postulated to bind close to residues Q79 in loop D and G189 in loop F of the chicken alpha7 nicotinic AChR.	nitro	4-9	cholinergic receptor nicotinic delta subunit	Gallus gallus	147-151
14575878-5	2003	Three-dimensional modeling of the alpha7 nicotinic AChR, based on the acetylcholine-binding protein (AChBP) of Lymnaea stagnalis, suggests that the reduced efficacy of imidacloprid following the G189E mutation is likely to result from carboxylate interference with the electronic interactions between the nitro group of imidacloprid and the basic residues in loop D.	nitro	305-310	cholinergic receptor nicotinic delta subunit	Gallus gallus	51-55
12713312-3	2003	Spin delocalization on the nitro group is proposed to explain the stability of the carbon-centered radical generated.	nitro	27-32	spindlin 1	Homo sapiens	0-4
14732339-7	2003	This enhancement was markedly potentiated by treatment of iNOS(-/-) mice with nitro.	nitro	78-83	nitric oxide synthase 2, inducible	Mus musculus	58-62
14732339-9	2003	Similar results were observed in iNOS(-/-) mice, in which these mechanisms were potentiated and reverted by nitro and L-arginine treatments, respectively.	nitro	108-113	nitric oxide synthase 2, inducible	Mus musculus	33-37
14530796-10	2003	Molecules like nitro-NSAIDs or tromethamine salt derivatives have been synthesized considering that both COX-1 and COX-2 are responsible for the synthesis of prostaglandins involved either in homeostatic functions or inflammation.	nitro	15-20	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	105-110
14530796-10	2003	Molecules like nitro-NSAIDs or tromethamine salt derivatives have been synthesized considering that both COX-1 and COX-2 are responsible for the synthesis of prostaglandins involved either in homeostatic functions or inflammation.	nitro	15-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
12747791-6	2003	Against CA II, low nanomolar inhibitors (1.1-5 nM) were phenylsulfamate and some of its 4-halogeno/nitro derivatives, n-octyl sulfamate, and estradiol 3,17beta-disulfamate among others.	nitro	99-104	carbonic anhydrase 2	Homo sapiens	8-13
11886806-4	2002	Besides retrieving several carboxylic acid derivatives, which are known to generally inhibit aldose reductase, docking proposed other families of putative inhibitors such as sulfonic acids, nitro-derivatives, sulfonamides and carbonyl derivatives.	nitro	190-195	aldo-keto reductase family 1 member B	Homo sapiens	93-109
12538053-8	2003	The large 15N isotope effect argues for a late transition state or Eu(III) interaction with the nitro group, and was also seen in Eu(III)-catalyzed hydrolysis of p-nitrophenyl phosphate.	nitro	96-101	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	70-73
12538053-8	2003	The large 15N isotope effect argues for a late transition state or Eu(III) interaction with the nitro group, and was also seen in Eu(III)-catalyzed hydrolysis of p-nitrophenyl phosphate.	nitro	96-101	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	133-136
12413844-2	2002	The nitro group was predicted to bind to the Tyr48 and His110 active site residues of the enzyme, the site where acidic ALR2 inhibitors such as carboxylic acids bind in their anionic form.	nitro	4-9	aldo-keto reductase family 1 member B	Homo sapiens	120-124
12128066-7	2002	cGMP production induced by methacholine, A23187 and thapsigargin was clearly inhibited by NG-nitro-L-arginine methylester (L-NAME), a specific inhibitor of nitric oxide synthase (NOS).	nitro	93-98	nitric oxide synthase, brain	Oryctolagus cuniculus	156-177
12324700-3	2002	In both 3-nitrobenzylidene-3"-iodoaniline and 4-nitrobenzylidene-3"-iodoaniline, (V) and (VI), a combination of C-H...O hydrogen bonds and iodo...nitro interactions generates molecular ladders that are linked into sheets by aromatic pi...pi stacking interactions, while in 2-nitrobenzylidene-4"-iodoaniline and 3-nitrobenzylidene-4"-iodoaniline, (VII) and (VIII), which both crystallize with Z" = 2 in C2/c and P1, respectively, the combination of C-H...O hydrogen bonds and iodo...nitro interactions generates sheets, which in (VIII) are further linked by pi...pi stacking interactions to form a three-dimensional structure.	nitro	10-15	cytochrome c oxidase subunit 8A	Homo sapiens	357-361
12324700-3	2002	In both 3-nitrobenzylidene-3"-iodoaniline and 4-nitrobenzylidene-3"-iodoaniline, (V) and (VI), a combination of C-H...O hydrogen bonds and iodo...nitro interactions generates molecular ladders that are linked into sheets by aromatic pi...pi stacking interactions, while in 2-nitrobenzylidene-4"-iodoaniline and 3-nitrobenzylidene-4"-iodoaniline, (VII) and (VIII), which both crystallize with Z" = 2 in C2/c and P1, respectively, the combination of C-H...O hydrogen bonds and iodo...nitro interactions generates sheets, which in (VIII) are further linked by pi...pi stacking interactions to form a three-dimensional structure.	nitro	10-15	complement C2	Homo sapiens	402-413
12324700-3	2002	In both 3-nitrobenzylidene-3"-iodoaniline and 4-nitrobenzylidene-3"-iodoaniline, (V) and (VI), a combination of C-H...O hydrogen bonds and iodo...nitro interactions generates molecular ladders that are linked into sheets by aromatic pi...pi stacking interactions, while in 2-nitrobenzylidene-4"-iodoaniline and 3-nitrobenzylidene-4"-iodoaniline, (VII) and (VIII), which both crystallize with Z" = 2 in C2/c and P1, respectively, the combination of C-H...O hydrogen bonds and iodo...nitro interactions generates sheets, which in (VIII) are further linked by pi...pi stacking interactions to form a three-dimensional structure.	nitro	10-15	cytochrome c oxidase subunit 8A	Homo sapiens	529-533
12324700-3	2002	In both 3-nitrobenzylidene-3"-iodoaniline and 4-nitrobenzylidene-3"-iodoaniline, (V) and (VI), a combination of C-H...O hydrogen bonds and iodo...nitro interactions generates molecular ladders that are linked into sheets by aromatic pi...pi stacking interactions, while in 2-nitrobenzylidene-4"-iodoaniline and 3-nitrobenzylidene-4"-iodoaniline, (VII) and (VIII), which both crystallize with Z" = 2 in C2/c and P1, respectively, the combination of C-H...O hydrogen bonds and iodo...nitro interactions generates sheets, which in (VIII) are further linked by pi...pi stacking interactions to form a three-dimensional structure.	nitro	48-53	cytochrome c oxidase subunit 8A	Homo sapiens	357-361
12324700-3	2002	In both 3-nitrobenzylidene-3"-iodoaniline and 4-nitrobenzylidene-3"-iodoaniline, (V) and (VI), a combination of C-H...O hydrogen bonds and iodo...nitro interactions generates molecular ladders that are linked into sheets by aromatic pi...pi stacking interactions, while in 2-nitrobenzylidene-4"-iodoaniline and 3-nitrobenzylidene-4"-iodoaniline, (VII) and (VIII), which both crystallize with Z" = 2 in C2/c and P1, respectively, the combination of C-H...O hydrogen bonds and iodo...nitro interactions generates sheets, which in (VIII) are further linked by pi...pi stacking interactions to form a three-dimensional structure.	nitro	48-53	complement C2	Homo sapiens	402-413
12324700-3	2002	In both 3-nitrobenzylidene-3"-iodoaniline and 4-nitrobenzylidene-3"-iodoaniline, (V) and (VI), a combination of C-H...O hydrogen bonds and iodo...nitro interactions generates molecular ladders that are linked into sheets by aromatic pi...pi stacking interactions, while in 2-nitrobenzylidene-4"-iodoaniline and 3-nitrobenzylidene-4"-iodoaniline, (VII) and (VIII), which both crystallize with Z" = 2 in C2/c and P1, respectively, the combination of C-H...O hydrogen bonds and iodo...nitro interactions generates sheets, which in (VIII) are further linked by pi...pi stacking interactions to form a three-dimensional structure.	nitro	48-53	cytochrome c oxidase subunit 8A	Homo sapiens	529-533
11868969-9	2002	In an atypical reaction for oximes, BIA 2-024 in rats was rapidly (t(max) = 2h) metabolized to the non-active 10-nitro-derivative (BIA 2-254), whereas rabbits and particularly mice oxidized the oxime moiety to a much lower extent.	nitro	113-118	tripartite motif containing 58	Homo sapiens	36-41
11868969-9	2002	In an atypical reaction for oximes, BIA 2-024 in rats was rapidly (t(max) = 2h) metabolized to the non-active 10-nitro-derivative (BIA 2-254), whereas rabbits and particularly mice oxidized the oxime moiety to a much lower extent.	nitro	113-118	tripartite motif containing 58	Homo sapiens	131-136
11868969-12	2002	In vitro data showed a very similar cross-species behaviour as the in vivo results; human liver microsomes catalysed the oxidation of BIA 2-024 to the nitro metabolite only at a low rate, and the same was observed for the subsequent metabolism to OXC.	nitro	151-156	tripartite motif containing 58	Homo sapiens	134-139
11708926-3	2001	Introduction of nitro and sulfonyl electron-withdrawing groups covalently bound to the P2" guanidine moiety rendered the inhibitors electronically neutral at cellular pH and led to potent inhibition of TNF-alpha release from stimulated macrophages.	nitro	16-21	tumor necrosis factor	Rattus norvegicus	202-211
11152460-6	2001	In general, CD22 ligand recognition appeared to be rather tolerant with respect to structural modifications of the anomeric sugar on a mono-, di-, and trisaccharide level, although affinity was increased by the presence of a nitro aromatic group at C-2.	nitro	225-230	CD22 molecule	Homo sapiens	12-16
11474839-7	2001	Many of the SOD1 mutations associated with FALS appear to increase the likelihood that the enzyme will perform either one of these potentially harmful functions resulting in increased hydroxyl radical formation or the addition of nitro groups to tyrosine residues within cellular proteins.	nitro	230-235	superoxide dismutase 1	Homo sapiens	12-16
11459640-2	2001	Structure-activity relationship (SAR) studies showed that a nitro group and two other electron-withdrawing groups are essential for these compounds to be potent inhibitors of VCAM-1 expression.	nitro	60-65	vascular cell adhesion molecule 1	Homo sapiens	175-181
11340659-1	2001	NAD(P)H:quinone oxidoreductase type 1 (QR1, NQO1, formerly DT-diaphorase; EC 1.6.99.2) is an FAD-containing enzyme that catalyzes the nicotinamide nucleotide-dependent reduction of quinones, quinoneimines, azo dyes, and nitro groups.	nitro	220-225	NAD(P)H quinone dehydrogenase 1	Homo sapiens	0-42
11340659-1	2001	NAD(P)H:quinone oxidoreductase type 1 (QR1, NQO1, formerly DT-diaphorase; EC 1.6.99.2) is an FAD-containing enzyme that catalyzes the nicotinamide nucleotide-dependent reduction of quinones, quinoneimines, azo dyes, and nitro groups.	nitro	220-225	NAD(P)H quinone dehydrogenase 1	Homo sapiens	44-48
11340659-1	2001	NAD(P)H:quinone oxidoreductase type 1 (QR1, NQO1, formerly DT-diaphorase; EC 1.6.99.2) is an FAD-containing enzyme that catalyzes the nicotinamide nucleotide-dependent reduction of quinones, quinoneimines, azo dyes, and nitro groups.	nitro	220-225	NAD(P)H quinone dehydrogenase 1	Homo sapiens	59-72
11535070-6	2001	MO calculations of nitrated BaP suggest that the perpendicular conformation of the nitro substituent to the aromatic ring is important for the release of NO with light.	nitro	83-88	prohibitin 2	Homo sapiens	28-31
11433534-5	2001	The MALDI time-of-flight mass spectrum of nitrated angiotensin II showed an unexpected prompt fragmentation involving the nitro group, in contrast to ESI-MS, where no fragmentation of nitrated angiotensin II was observed.	nitro	122-127	angiotensinogen	Homo sapiens	51-65
11433534-8	2001	The dinitrated angiotensin II contained two nitro groups on the tyrosine residue.	nitro	44-49	angiotensinogen	Homo sapiens	15-29
11347911-7	2001	Of the RDX that was mineralized to N2O, one N originated from the ring and the other from the nitro group substituent, as determined using N15 ring-labeled RDX.	nitro	94-99	radixin	Homo sapiens	7-10
11313595-4	2001	In (IV), the C-4 nitro group is nearly perpendicular to the imidazole ring and the C-4-NO(2) bond length is comparable to the value for a normal single Csp(2)-NO(2) bond.	nitro	17-22	complement C4A (Rodgers blood group)	Homo sapiens	13-16
9702206-4	1998	The antiproliferative activity and the maximum potency of antiviral activity correlate with the presence of both the 2-pyridyl moiety bound at the ethylenic bridge in C-2 of benzimidazole and the nitro group in the benzene ring.	nitro	196-201	complement C2	Homo sapiens	167-170
11114788-9	2000	Incubation of calf thymus DNA with organic extracts from particulate matter and xanthine oxidase allowed the detection of five nitro-PAH-DNA adducts.	nitro	127-132	phenylalanine hydroxylase	Bos taurus	133-136
10650914-2	1999	In order to assess whether the levels of some biomarkers (PAH-DNA adducts, nitro-PAH adducts to Hb and MN frequency) could be modulated by the genetic metabolic polymorphisms for CYP1A1 and GSTM1, we analysed in 76 coke-oven workers and 18 controls the CYP1A1 (MspI and Ile/Val sites) and the GSTM1 genotypes by a PCR assay.	nitro	75-80	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	179-185
10214711-1	1999	A complete remote control system was constructed for production of the PET 5-HT2A ligand [18F]altanserin by nitro-for-fluoro exchange.	nitro	108-113	5-hydroxytryptamine receptor 2A	Homo sapiens	77-81
10609886-4	1999	A model explaining the reactivity of dinitrohalobenzenes with thioredoxin reductase is presented, involving dinitrophenyl-derivatization of both the selenocysteine residue and its neighboring cysteine residue, reduction by NADPH of the enzyme-bound flavin in dinitrophenyl-alkylated enzyme (dnp-TrxR), followed by two consecutive one-electron transfers from the flavin to nitro groups of the dnp-moieties in dnp-TrxR, forming nitro anion radicals.	nitro	39-44	thioredoxin	Homo sapiens	62-73
10197616-11	1999	These results, the first report on the comparative metabolism of mono-NP in humans, clearly demonstrate that the role of specific human P450 enzymes in catalyzing oxidative and reductive pathways of mono-NP is dependent upon the position of the nitro group.	nitro	245-250	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	136-140
9894022-9	1999	MS/MS analysis gave an NO2- fragment, and 15N NMR indicated that the product contained a nitro (RNO2) functional group, suggesting that the product was nitroepoxylinoleic acid [L(O)NO2].	nitro	89-94	NLR family pyrin domain containing 12	Homo sapiens	96-100
9826512-7	1998	Release of p-nitrophenol is facilitated due to the unfavourable interaction of the partial charge of the nitro group of p-nitrophenolate with the hydrophobic cavity where it is located, and to the absence of a direct hydrogen bond between the product and the Fab.	nitro	13-18	FA complementation group B	Homo sapiens	259-262
11667330-3	1996	In all the examined cases boroxy nitroxides, RN(O(*))OBLH(2), resulting from the addition of ligated boryl radicals, LBH(2)(*), to an oxygen atom of the nitro group were detected and characterized by EPR spectroscopy.	nitro	33-38	LBH regulator of WNT signaling pathway	Homo sapiens	117-120
9603906-4	1998	Mass spectroscopic analysis of the peroxynitrite-inactivated Mn-SOD showed an increased molecular mass because of a single nitro group substituted onto a tyrosine residue.	nitro	123-128	superoxide dismutase 2	Homo sapiens	61-67
9364740-10	1997	The involvement of these two isoforms in the O-demethylation of 4-nitroanisole can be rationalized in terms of a hydrogen bond interaction with the nitro group and the active site of CYP2A6 and a hydrophobic interaction with the active site of CYP2E1.	nitro	66-71	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	183-189
9364740-10	1997	The involvement of these two isoforms in the O-demethylation of 4-nitroanisole can be rationalized in terms of a hydrogen bond interaction with the nitro group and the active site of CYP2A6 and a hydrophobic interaction with the active site of CYP2E1.	nitro	66-71	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	244-250
9172695-1	1997	Changes in ESR signals from the active form of cyt P-450 in mouse liver samples after administration of some nitro compounds were studied by the ESR method.	nitro	109-114	esterase 5 regulator	Mus musculus	11-14
9172695-2	1997	It is shown that administration of nitro compounds leads to the formation of nitrosyl cyt P-450-NO complexes and a decrease in the ESR signal from cyt P-450 within the first 1-2 h after administration, indicating the inhibition of enzyme activity.	nitro	35-40	esterase 5 regulator	Mus musculus	131-134
9343369-1	1997	We have synthesized a number of nitrobenzimidazoles containing nitro groups in the benzene ring and found that they acted as relatively efficient substrates for rat liver DT-diaphorase (EC 1.6.99.2), their reactivity exceeding reactivities of nitrofurans and nitrobenzenes.	nitro	32-37	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	171-184
7767940-14	1995	These observations suggest that the initial reduction of the nitro group can be catalyzed by NADPH cytochrome P450 reductase alone but cytochrome P450 is needed in the reduction of the hydroxylamine to the amine.	nitro	61-66	cytochrome p450 oxidoreductase	Rattus norvegicus	115-124
7591216-9	1995	These results (i) are consistent with the specific inhibition of topoisomerase II or tubulin by azatoxin derivatives in cells; (ii) indicate that the nitro group of nitroanilinoazatoxin allows recognition and efflux by the P-glycoprotein; and (iii) suggest that cross-resistance of K562/ADM cells to other azatoxin derivatives is not mediated by P-glycoprotein.	nitro	150-155	ATP binding cassette subfamily B member 1	Homo sapiens	223-237
7591216-9	1995	These results (i) are consistent with the specific inhibition of topoisomerase II or tubulin by azatoxin derivatives in cells; (ii) indicate that the nitro group of nitroanilinoazatoxin allows recognition and efflux by the P-glycoprotein; and (iii) suggest that cross-resistance of K562/ADM cells to other azatoxin derivatives is not mediated by P-glycoprotein.	nitro	150-155	ATP binding cassette subfamily B member 1	Homo sapiens	346-360
8625944-8	1996	The results indicate that nitro substitution at C1 or C3 of BaP-DE reduces mutational potency in CHO cells and appears to have only subtle effects upon the mutational pattern in the hprt gene.	nitro	26-31	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	182-186
7612649-6	1995	Results show that the effect of reversible soman binding on butyrylcholinesterase activity in the presence of amiloride depends on the position of the substrate nitro group and amiloride concentration.	nitro	161-166	butyrylcholinesterase	Homo sapiens	60-81
7947734-0	1994	A-ring nitro- and amino-substituted estradiol analogs produce a negative cooperative or noncooperative [3H]estradiol-estrogen receptor binding mechanism.	nitro	7-12	estrogen receptor 1	Bos taurus	117-134
7947734-7	1994	The presence of a nitro group on C4 eliminated the positive cooperativity of the [3H]estradiol-estrogen receptor interaction; the Hill coefficient of [3H]estradiol binding in the presence of the analog was 0.99 compared with 1.7 for [3H]estradiol alone.	nitro	18-23	estrogen receptor 1	Bos taurus	95-112
8200499-8	1994	These trials has pointed out the followings: 1) prompt therapy (within 24 hours of chest pain) with ACE inhibitors is able to improve short term survival in patients with clinical evidence of heart failure, in women and old patients; 2) ACE inhibitors and nitro derivatives are complementary therapies in the acute and subacute phase of infarction, and their association produces the best improvement in short-term survival.	nitro	256-261	angiotensin I converting enzyme	Homo sapiens	100-103
7925401-5	1994	Introduction of 1.6 nitro groups/polypeptide chain resulted in a fivefold increase in binding affinity for cytochrome P-450 2B4 (P-450 2B4), whereas spectral interaction with cytochrome c remained unaffected.	nitro	20-25	cytochrome P450 2B4	Oryctolagus cuniculus	107-127
1629932-2	1992	The mutagenic potency of TNT decreased in proportion to the number of nitro groups that were reduced to the amino form.	nitro	70-75	troponin T3, fast skeletal type	Rattus norvegicus	25-28
1469689-1	1992	A series of nitro derivatives of dihydroxy- and hydroxymethoxybenzaldehyde was synthesized and tested as potential inhibitors of partially purified pig liver catechol-O-methyltransferase (COMT).	nitro	12-17	catechol-O-methyltransferase	Sus scrofa	158-186
1469689-1	1992	A series of nitro derivatives of dihydroxy- and hydroxymethoxybenzaldehyde was synthesized and tested as potential inhibitors of partially purified pig liver catechol-O-methyltransferase (COMT).	nitro	12-17	catechol-O-methyltransferase	Sus scrofa	188-192
1469689-3	1992	Although previously reported data showed that the presence of electron-withdrawing substituents at position 5 seemed to be very important for activity as COMT inhibitor, our results suggest that the requirement necessary to enhance the activity of the dihydroxyni-trobenzaldehyde derivatives toward COMT is the presence of the nitro group in a position ortho with respect to one hydroxyl group.	nitro	327-332	catechol-O-methyltransferase	Sus scrofa	154-158
2013125-11	1991	Our results represent the first direct demonstration of a C8-deoxyadenosine adduct being formed as a major product from the reaction of a nitro-PAH metabolite with DNA.	nitro	138-143	phenylalanine hydroxylase	Rattus norvegicus	144-147
1515143-4	1992	This sensitive blotting procedure utilizing AMPPD, a polyclonal rabbit anti-transferrin:goat anti-rabbit IgG-alkaline phosphatase detection complex, and a PVDF membrane blocked with Nitro-Block permits the detection of 125 pg (1.6 fmol) of human transferrin.	nitro	182-187	transferrin	Homo sapiens	246-257
1893513-4	1991	The nitro-reduction of 20 microM [4,5,9,10-3H]1-nitropyrene or 20 microM [4-3H]3-nitrofluoranthene by aldehyde oxidase required the presence of flavin mononucleotide (FMN) or flavin adenine dinucleotide (FAD), and was inhibited by oxygen in a concentration-dependent manner.	nitro	4-9	aldehyde oxidase 1	Homo sapiens	102-118
2087623-16	1990	The application of 1 mg Nitro-Mack intravenously was followed by a significant decrease in RAP, PAP, AOP and CO.(ABSTRACT TRUNCATED AT 400 WORDS)	nitro	24-29	LDL receptor related protein associated protein 1	Homo sapiens	91-94
34320448-0	2021	Increased nitro-oxidative toxicity in association with metabolic syndrome, atherogenicity and insulin resistance in patients with affective disorders.	nitro	10-15	insulin	Homo sapiens	94-101
32796938-6	2020	We further show that the NAC catalyst is versatile for dehydrogenation of ethylbenzene and tetrahydroquinoline as well as for hydrogenation of common unsaturated functionalities, including ketone, alkene, alkyne, and nitro groups.	nitro	217-222	synuclein alpha	Homo sapiens	25-28
34688713-7	2022	The results of the studies indicate that bismuth vanadate modified electrode exhibited four electron transfer process for reduction of nitro group and this lead to the superior electrochemical sensing performance for ethyl Paraoxon with a detection limit of 0.03 muM and good sensitivity 0.345 muA muM-1 cm-2 with excellent reproducibility, repeatability, stability and selectivity over common interferents.	nitro	135-140	PWWP domain containing 3A, DNA repair factor	Homo sapiens	298-303
34936721-5	2022	Moreover, CP-1 exhibited green luminescence in live cells after imaging very low concentration of H 2 S, while the nitro analogue, CP-2, couldn"t detect the target analyte due to it"s framework disruption.	nitro	115-120	ceruloplasmin	Homo sapiens	131-135
34426189-8	2021	These results suggest that exposure to certain nitro-PAHs affects glucose homeostasis, partly resulting from the depletion of insulin-stimulating amino acids (Asp, Glu, and Orn).	nitro	47-52	insulin	Homo sapiens	126-133
34959631-2	2021	Hypoxia selectivity results from one-electron nitro reduction of PR-104A, in which cytochrome P450 oxidoreductase (POR) plays an important role.	nitro	46-51	cytochrome p450 oxidoreductase	Homo sapiens	83-113
34959631-2	2021	Hypoxia selectivity results from one-electron nitro reduction of PR-104A, in which cytochrome P450 oxidoreductase (POR) plays an important role.	nitro	46-51	cytochrome p450 oxidoreductase	Homo sapiens	115-118
34732048-8	2021	This study provides quantitative insights on the formation and impacts of gaseous NPs in the continental outflow and highlights the role of NO3  chemistry in the secondary nitro-aromatics production that may facilitate regional pollution.	nitro	172-177	NBL1, DAN family BMP antagonist	Homo sapiens	140-143
35149995-11	2022	Taken together, our results suggest that AOX play an important role in the mitigation of ROS and RNS levels and enhance plant growth, thus providing tolerance against nitro-oxidative stress exerted by NaCl.	nitro	167-172	alternative oxidase 2	Arabidopsis thaliana	41-44
34641548-0	2021	Selected Class of Enamides Bearing Nitro Functionality as Dual-Acting with Highly Selective Monoamine Oxidase-B and BACE1 Inhibitors.	nitro	35-40	beta-secretase 1	Homo sapiens	116-121
35257853-6	2022	Hyperglycemia induced nitro-oxidative stress appears to involve reduction in redox ratio (GSH/GSSG) and enzymatic antioxidants; catalase (CAT) and superoxide dismutase (SOD) in cortex and hippocampus.	nitro	22-27	catalase	Mus musculus	128-136
35257853-6	2022	Hyperglycemia induced nitro-oxidative stress appears to involve reduction in redox ratio (GSH/GSSG) and enzymatic antioxidants; catalase (CAT) and superoxide dismutase (SOD) in cortex and hippocampus.	nitro	22-27	catalase	Mus musculus	138-141
35599239-5	2022	Especially, compound 3f bearing the nitro substituent was found to be the most promising compound on BChE in the series.	nitro	36-41	butyrylcholinesterase	Homo sapiens	101-105
3137698-5	1988	The microsomal production of DCAP can be inhibited by the addition of specific antibodies to cytochrome P-450d, thus indicating that the removal of the nitro group and subsequent replacement with a hydroxyl group was initiated by cytochrome P-450d in the mixed-function oxidase system.	nitro	152-157	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	93-110
35056740-3	2022	Here, we designed and synthesized a novel theranostic agent H6M based on the "double-locked" strategy by introducing an electron-withdrawing nitro group into 1-position of a pH-responsive 3-amino-beta-carboline and further covalently linking the hydroxamic acid group, a zinc-binding group (ZBG), to the 3-position of beta-carboline to obtain histone deacetylase (HDAC) inhibitory effect for combined HDAC-targeted therapy.	nitro	141-146	phenylalanine hydroxylase	Homo sapiens	174-176
3137698-5	1988	The microsomal production of DCAP can be inhibited by the addition of specific antibodies to cytochrome P-450d, thus indicating that the removal of the nitro group and subsequent replacement with a hydroxyl group was initiated by cytochrome P-450d in the mixed-function oxidase system.	nitro	152-157	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	230-247
3593260-2	1987	In the presence of NADH, lipoamide dehydrogenase reduces the nitro group of 4-nitropyridine and 4-nitropyridine N-oxide.	nitro	61-66	dihydrolipoamide dehydrogenase	Homo sapiens	25-48
2827059-4	1987	In a series of patients with essential arterial hypertension treated with ACE inhibitors, 6 developed first dose syndrome, two of them after captopril and 4 after enalapril maleate, two of whom were also receiving theophylline and nitro derivates.	nitro	231-236	angiotensin I converting enzyme	Homo sapiens	74-77
3480514-6	1987	The results with the nitro analogue show that the enzyme can also bind a substrate-like ligand to the cluster in the alternative isocitrate mode (carboxyl at C-1), as is implicit in models proposed for the aconitase reaction.	nitro	21-26	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	158-161
2968964-1	1988	(D-Trp)6-LHRH:pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-GlyNH2 was prepared by solid-phase peptide synthesis using the nitro group to protect the guanidine side chain of the arginyl residue.	nitro	116-121	gonadotropin releasing hormone 1	Homo sapiens	9-13
2901184-0	1988	The synthetic peptide GRF (1-29)-NH2 with growth hormone releasing activity penetrates human epidermis in nitro.	nitro	106-111	growth hormone releasing hormone	Homo sapiens	22-25
3116788-5	1987	Patients, regularly taking nitro-remedies, showed enhanced NO3--(25.8 mg/l) and NO2--(8.4 mg/l)-values.	nitro	27-32	NBL1, DAN family BMP antagonist	Homo sapiens	59-62
3593260-5	1987	Nitro reduction catalysed by lipoamide dehydrogenase was monitored spectrophotometrically and chromatographically.	nitro	0-5	dihydrolipoamide dehydrogenase	Homo sapiens	29-52
3752953-5	1986	3-ABP was also converted to the corresponding hydroxylamine, nitroso and nitro compound although the latter may have arisen via a non enzymic process.	nitro	61-66	amine oxidase, copper containing 1	Rattus norvegicus	2-5
3021349-10	1986	The data indicated that reduced nitro- and nitrosopyrene intermediates were directly reducing succinoylated cytochrome c and that the assay could be used as a measure of aerobic nitroreduction.	nitro	32-37	cytochrome c, somatic	Homo sapiens	108-120
3713815-5	1986	Evidence for the atmospheric formation of nitro-PAH has come only recently, from observations that 2-nitropyrene (2-NP) and 2-nitrofluoranthene (2-NF) neither of which has been reported to be emitted from combustion sources, are among the major nitro-PAH present in ambient air.	nitro	42-47	Henna	Drosophila melanogaster	48-51
3713815-5	1986	Evidence for the atmospheric formation of nitro-PAH has come only recently, from observations that 2-nitropyrene (2-NP) and 2-nitrofluoranthene (2-NF) neither of which has been reported to be emitted from combustion sources, are among the major nitro-PAH present in ambient air.	nitro	42-47	Henna	Drosophila melanogaster	251-254
6547814-0	1984	Nitro analogs of substrates for argininosuccinate synthetase and argininosuccinate lyase.	nitro	0-5	argininosuccinate lyase	Homo sapiens	65-88
4031869-4	1985	On the other hand, both the nitro and the azido groups of FNPA were shown to be important for FNPA inactivation of two types of MAO.	nitro	28-33	monoamine oxidase B	Rattus norvegicus	128-131
6474483-1	1984	Musk ambrette (2,6-dinitro-3-methoxy-4-tert-butyltoluene), a nitro-musk compound widely used as a fixative in fragrance formulations and found to a lesser degree in flavor compositions, produces hindlimb weakness when administered in the diet or applied to skin of rats for periods up to 12 weeks.	nitro	21-26	muscle associated receptor tyrosine kinase	Rattus norvegicus	0-4
6547814-1	1984	The nitro analogs of aspartate and argininosuccinate were synthesized and tested as substrates and inhibitors of argininosuccinate synthetase and argininosuccinate lyase, respectively.	nitro	4-9	argininosuccinate lyase	Homo sapiens	146-169
6547814-5	1984	The nitro analog of argininosuccinate, N3-(L-1-carboxy-2-nitroethyl)-L-arginine, was a strong competitive inhibitor of argininosuccinate lyase but was not a substrate.	nitro	4-9	argininosuccinate lyase	Homo sapiens	119-142
6152049-2	1984	The action of nitroimidazole derivatives on the erythrocyte membrane ATP-ase activity differed depending on the nitro group position.	nitro	14-19	dynein axonemal heavy chain 8	Homo sapiens	69-76
6428413-3	1984	This demonstrated that the nitro compounds activated the hexose monophosphate shunt and is evidence that an important pathway of nitro reduction in these cell lines is electron transfer from NADPH-dependent cytochrome c reductase to the nitro group.	nitro	27-32	cytochrome c, somatic	Homo sapiens	207-219
6428413-3	1984	This demonstrated that the nitro compounds activated the hexose monophosphate shunt and is evidence that an important pathway of nitro reduction in these cell lines is electron transfer from NADPH-dependent cytochrome c reductase to the nitro group.	nitro	129-134	cytochrome c, somatic	Homo sapiens	207-219
6428413-3	1984	This demonstrated that the nitro compounds activated the hexose monophosphate shunt and is evidence that an important pathway of nitro reduction in these cell lines is electron transfer from NADPH-dependent cytochrome c reductase to the nitro group.	nitro	129-134	cytochrome c, somatic	Homo sapiens	207-219
6141677-6	1983	In the presence of the vital stain methylene blue - which was shown in vitro to prevent nitrate-induced activation of guanylate cyclase, the enzyme which forms cGMP from GTP - the relaxant actions as well as the increases in cGMP produced by several of these nitro-compounds in coronary strips were almost abolished.	nitro	259-264	guanylate cyclase	Bos taurus	118-135
6699544-1	1984	Previous work has shown that the injection of antiidiotope antibodies specific for idiotopes of the germline-encoded anti-(4-hydroxy-3-nitro-phenyl) acetyl (NP) antibody B1-8 enhanced or suppressed the expression of B1-8 idiotopes in subsequent humoral anti-NP responses, depending on the dose and perhaps also the isotype of the injected antibody.	nitro	135-140	bradykinin receptor, beta 2	Mus musculus	170-174
115635-0	1979	Allergic contact dermatitis secondary to nitroglycerin in Nitro-Bid ointment.	nitro	58-63	BH3 interacting domain death agonist	Homo sapiens	64-67
16345884-2	1981	A scheme for the biodegradation of RDX is proposed which proceeds via successive reduction of the nitro groups to a point where destabilization and fragmentation of the ring occurs.	nitro	98-103	radixin	Homo sapiens	35-38
110443-7	1979	Both V79 and Ehrlich cells contained appreciable amounts of glutathione S-transferase (EC 2.5.1.18), which catalyzes the nucleophilic substitution of the nitro group of 4-NQO with thiols.	nitro	154-159	hematopoietic prostaglandin D synthase	Mus musculus	60-85
1246040-5	1976	From Lineweaver-Burke plots, nitro compounds were shown to competitively interact with type II compounds for cytochrome p-450 binding sites.	nitro	29-34	cytochrome P-450	Oryctolagus cuniculus	109-125
181049-9	1976	We have previously reported that the enzymatic activities of these reconstituted nitro and amino derivatives toware cytochrome c reduction in the presence of adrenodoxin reductase and reduced nicotinamide adenine dinucleotide phosphate were 19 and 7% of native adrenodoxin, respectively.	nitro	81-86	LOC104968582	Bos taurus	116-128
181049-9	1976	We have previously reported that the enzymatic activities of these reconstituted nitro and amino derivatives toware cytochrome c reduction in the presence of adrenodoxin reductase and reduced nicotinamide adenine dinucleotide phosphate were 19 and 7% of native adrenodoxin, respectively.	nitro	81-86	ferredoxin reductase	Bos taurus	158-179
240656-5	1975	There is apparent mutual inhibition of binding of carbon monoxide, metyrapone, and nitro compounds with reduced cytochrome P-450, since addition of metyrapone or carbon monoxide to reference and sample cuvettes does not alter qualitative aspects of the nitro binding spectra, but only its magnitude.	nitro	83-88	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	112-128
1150656-2	1975	Reaction of tetranitromethane with the lone tyrosine residue of bovine neurophysin I and II, tyrosine-49, gave nitro derivatives of these proteins which were obtained in a highly purified form by preparative electrophoresis.	nitro	17-22	arginine vasopressin	Bos taurus	71-104
33826336-2	2021	Introducing a methyl group at the alpha-position of nitro group generated two diastereomers, the greater potency and efficacy of erythro, (+-)-9 vs threo, (+-)-10 constitutes the first demonstration of diastereoselective CB1R-allosteric modulator interaction.	nitro	52-57	cannabinoid receptor 1 (brain)	Mus musculus	221-225
13224424-0	1954	[Methemoglobin in nitro and amino compounds poisoning].	nitro	18-23	hemoglobin subunit gamma 2	Homo sapiens	1-14
34048738-7	2021	Meanwhile, large amount of nicotinamide adenine dinucleotide phosphate (NADPH) can be consumed to decrease the synthesis of GSH during the bio-reduction process of the nitro group in PLC under hypoxic conditions.	nitro	168-173	heparan sulfate proteoglycan 2	Homo sapiens	183-186
33453599-0	2021	Study of photo induced charge transfer mechanism of PEDOT with nitro groups of RDX, HMX and TNT explosives using anti-stokes and stokes Raman lines ratios.	nitro	63-68	chromosome 16 open reading frame 82	Homo sapiens	92-95
33453800-6	2021	After reaction with NTR accompanied by NADH as an electron donor, the nitro group in the RCO-NTR probe can be reduced and then the RCOH fluorophore can be released through rearrangement and elimination, leading to the enhancement of fluorescence signal.	nitro	70-75	neurotensin receptor 1	Homo sapiens	20-23
33709693-0	2021	Rip It off: Nitro to Nitroso Reduction by Iron Half-Sandwich Complexes.	nitro	12-17	receptor interacting serine/threonine kinase 1	Homo sapiens	0-3
33453800-6	2021	After reaction with NTR accompanied by NADH as an electron donor, the nitro group in the RCO-NTR probe can be reduced and then the RCOH fluorophore can be released through rearrangement and elimination, leading to the enhancement of fluorescence signal.	nitro	70-75	neurotensin receptor 1	Homo sapiens	93-96
33498695-2	2021	Herein, nitro-introduced dipyrrolyldiketone BF2 complexes as anion-responsive pi-electronic molecules were synthesized, and their electronic properties and anion-binding abilities were investigated by spectroscopic analyses and theoretical studies.	nitro	8-13	forkhead box G1	Homo sapiens	44-47
33122195-4	2020	Herein we report that electrophilic nitro-fatty acids (nitro-oleic acid and nitro-conjugated linoleic acid) potently activate SIRT6.	nitro	36-41	sirtuin 6	Homo sapiens	126-131
33249154-11	2021	Molecular docking analysis revealed the formation of several H-bonding interactions through the ester carbonyl and the nitro oxygens of 3c with the side chains of His348, Arg212 and His279 in the active pocket of alpha-glucosidase whereas 3b interacted with His95, -OH of Thr197, Thr198 and WAT462 in the active site of carbonic anhydrase-II.	nitro	119-124	carbonic anhydrase 2	Homo sapiens	320-341
33189994-1	2020	In this study, various N-heterocyclic nitro prodrugs (NHN1-16) containing pyrimidine, triazine and piperazine rings were designed and synthesized.	nitro	38-43	zinc finger CCCH-type containing 18	Homo sapiens	54-58
32545500-7	2020	Moreover, the orientation of the nitro-group in CL-20 or FOX-7 with regard to the MgH2 (110) surface plays an important role on whether and how the energetic molecule decomposes.	nitro	33-38	epithelial membrane protein 1	Homo sapiens	48-53
32960575-2	2020	Here we report the reactivity of selected nitro substrates RNO2 (R = Me, Ph, p-C6H4CHO) with pyrazolate-based dinickel(II) dihydride complexes [ML(NiH)2] (M = Na, K); the latter eliminate H2 upon substrate binding and serve as a masked dinickel(I) platform.	nitro	42-47	NLR family pyrin domain containing 12	Homo sapiens	59-63
32960575-2	2020	Here we report the reactivity of selected nitro substrates RNO2 (R = Me, Ph, p-C6H4CHO) with pyrazolate-based dinickel(II) dihydride complexes [ML(NiH)2] (M = Na, K); the latter eliminate H2 upon substrate binding and serve as a masked dinickel(I) platform.	nitro	42-47	phenylalanine hydroxylase	Homo sapiens	73-75
33078806-1	2020	Here, we used malononitrile or AMBN as a cyanating agent to develop efficient and practical protocols for Cu-mediated decarboxylative cyanations, under aerobic conditions, of aryl carboxylic acids bearing nitro and methoxyl substituents at the ortho position as well as of heteroaromatic carboxylic acids.	nitro	205-210	ameloblastin	Homo sapiens	31-35
32377662-1	2020	Rapid "in-field" detection of environmentally hazardous organophosphorus and nitro-containing pesticides is highly essential due to the lethal effects caused by the inhibition of the activity of acetylcholinesterase (AChE).	nitro	77-82	acetylcholinesterase (Cartwright blood group)	Homo sapiens	195-215
32377662-1	2020	Rapid "in-field" detection of environmentally hazardous organophosphorus and nitro-containing pesticides is highly essential due to the lethal effects caused by the inhibition of the activity of acetylcholinesterase (AChE).	nitro	77-82	acetylcholinesterase (Cartwright blood group)	Homo sapiens	217-221
32493948-5	2020	The results indicated that Pb(II) was immobilized as lead oxalate outside the fungal cell, bound with phosphate, nitro, halide, hydroxyl, amino, and carboxyl groups on the cell wall, precipitated as pyromorphite [Pb5(PO4)3Cl] on the cell wall, and reduced to Pb(0) inside the cell.	nitro	113-118	submaxillary gland androgen regulated protein 3B	Homo sapiens	27-33
32499803-9	2020	Finally, AOX was particularly important in preventing nitro-oxidative stress during the reoxygenation period, thereby contributing positively to the recovery of energy status following hypoxia.	nitro	54-59	ubiquinol oxidase 1, mitochondrial	Nicotiana tabacum	9-12
31963524-7	2020	We focused on the implication of Hsp90 and Hsp70 in control under expression of neuronal nitric oxide synthase, localization of the enzyme, and further generation of nitro-oxidative stress.	nitro	166-171	heat shock protein 90 alpha family class A member 1	Homo sapiens	33-38
32305006-2	2020	Previously, our group evidenced that from mechanistic point of view one of anticancer mechanisms of action of 2-ME is specific induction and nuclear hijacking of neuronal nitric oxide synthase (nNOS), resulting in local generation of nitro-oxidative stress and finally, cancer cell death.	nitro	234-239	nitric oxide synthase 1	Homo sapiens	162-192
32305006-2	2020	Previously, our group evidenced that from mechanistic point of view one of anticancer mechanisms of action of 2-ME is specific induction and nuclear hijacking of neuronal nitric oxide synthase (nNOS), resulting in local generation of nitro-oxidative stress and finally, cancer cell death.	nitro	234-239	nitric oxide synthase 1	Homo sapiens	194-198
32353998-6	2020	This result indicates that the substituting ability of nitronate is higher than that of enolate for the direct SN2 substitution of a nitro group.	nitro	55-60	solute carrier family 38 member 5	Homo sapiens	111-114
31057090-7	2020	The combined modeling analysis revealed that the presence of aryl hydrazyl sulphonyl moiety, furazan ring, halogen substitution, nitro group and hetero atoms in aromatic system can be very useful in designing IDO1 inhibitors.	nitro	129-134	indoleamine 2,3-dioxygenase 1	Homo sapiens	209-213
31325829-4	2019	The presence of NACs (up to 0.5 mM) effectively suppressed the AChE-catalyzed hydrolysis of acetylthiocholine iodide, with the suppression effect increasing with the nitro-group substitution (TNB > DNB > NB).	nitro	166-171	acetylcholinesterase (Cartwright blood group)	Homo sapiens	63-67
31460469-2	2019	CL-20 in these complexes was surrounded by methyl, nitro, and amino derivatives of 4-nitropyrazole.	nitro	51-56	epithelial membrane protein 1	Homo sapiens	0-5
30727777-3	2019	The results of the biological testing demonstrated that the presence of the hydrazothiazole nucleus bearing at C4 a phenyl ring functionalised at the meta position with a nitro group represents an important pharmacophoric feature to obtain selective and reversible human MAO-B inhibition for the treatment of neurodegenerative disorders.	nitro	171-176	monoamine oxidase B	Homo sapiens	271-276
31347761-6	2019	To the best of our knowledge, this work represents the first TbIII -based MOF as an efficient fluorescent sensor for detecting metal ions, inorganic anions, nitro-compounds, and antibiotics simultaneously.	nitro	157-162	lysine acetyltransferase 8	Homo sapiens	74-77
31364627-2	2019	Furthermore, by comparing (2-(3,3-dimethyl-3H-indol-2-yl)vinyl)-4-nitrophenol (AM-N) with the control molecules de-nitrated AM, nitro-mismatched OM-N and methylated AM-N-C, it was found that the pressure-triggered proton transfer in the crystal was not a simple loss or gain of protons as that in solution; instead, it involved the sharing of protons by their gradual deviation from a proton donor to a proton acceptor.	nitro	66-71	amnion associated transmembrane protein	Homo sapiens	79-83
31414099-6	2019	Chalcones holding nitro groups and chloro substituents, together with a hydroxy group in the chalcone scaffold, showed strong inhibition of the alpha-glucosidase activity.	nitro	18-23	sucrase-isomaltase	Homo sapiens	144-161
31078851-0	2019	PM2.5-associated nitro-PAH exposure promotes tumor cell metastasis through Hippo-YAP mediated transcriptional regulation.	nitro	17-22	Yes1 associated transcriptional regulator	Homo sapiens	81-84
30779238-5	2019	In fact, the transformation product, p-nitrophenol (p-NP), becomes a substrate for further reaction with BSA in which its nitro group in subtracted and released in the form of HNO2 .	nitro	39-44	purine nucleoside phosphorylase	Homo sapiens	52-56
31230245-8	2019	The XPS of smectite further manifested the cation-nitro interactions that the binding energies of K 2p 1/2, K 2p 3/2, and Si 2p shifted higher with 1,3-DNB adsorbed.	nitro	50-55	potassium two pore domain channel subfamily K member 1	Homo sapiens	98-127
30981774-0	2019	Voltammetric determination of nitro compound 4-nitroaniline in aqueous medium at chitosan gelified modified carbon paste electrode (CS@CPE).	nitro	30-35	carboxypeptidase E	Homo sapiens	135-138
32830652-8	2019	The results revealed that the O-H...O hydrogen bonding interaction between the phenolic hydroxyl group of TNP and nitro groups of CL-20, as well as nitro...pi, nitro...nitro and ONO2...pi(N)NO2 interactions, based on the benzene ring and nitro groups, are the main interactions occurring in the cocrystal.	nitro	114-119	epithelial membrane protein 1	Homo sapiens	130-135
30920217-8	2019	The best theoretical results reported in the literature so far, viz., density functional theory energies of nitro group radical elimination in CL-20 and ONC, underestimate the value by ~10 kcal mol-1.	nitro	108-113	epithelial membrane protein 1	Homo sapiens	143-148
30586198-7	2019	In the pituitary gland, we also detected an increase in the expression levels of proopiomelanocortin (POMC) that was accompanied by increased levels of: lipoperoxides, nitro-tyrosine modified proteins, catalase, heme oxygenase-1, interleukin-1beta mRNA, and by an increase in the tissue number of inflammatory cells (F4/80 and Iba-1 positive cells).	nitro	168-173	pro-opiomelanocortin-alpha	Mus musculus	81-100
30896160-5	2019	The nitro-substituted quinazolin-4(3 H)-one 2k inhibited NLRP3 inflammasome (IC50 5 muM) via the suppression of IL-1beta release from ATP-stimulated J774A.1 cells.	nitro	4-9	NLR family, pyrin domain containing 3	Mus musculus	57-62
30896160-5	2019	The nitro-substituted quinazolin-4(3 H)-one 2k inhibited NLRP3 inflammasome (IC50 5 muM) via the suppression of IL-1beta release from ATP-stimulated J774A.1 cells.	nitro	4-9	interleukin 1 beta	Mus musculus	112-120
30928710-3	2019	For this aim, nitro containing aromatic amides (A1-A23)2 were designed, synthesized, performed in silico ADMET and molecular docking techniques in this study.	nitro	14-19	immunoglobulin kappa variable 2-24	Homo sapiens	51-54
30822734-3	2019	The study of sensing properties of all molecules towards several metal ions showed that the one and two nitro-bearing N1 and N2 derivatives responded selectively to Cr3+ in MeCN with a color change from pink to colorless.	nitro	104-109	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	165-168
30586198-7	2019	In the pituitary gland, we also detected an increase in the expression levels of proopiomelanocortin (POMC) that was accompanied by increased levels of: lipoperoxides, nitro-tyrosine modified proteins, catalase, heme oxygenase-1, interleukin-1beta mRNA, and by an increase in the tissue number of inflammatory cells (F4/80 and Iba-1 positive cells).	nitro	168-173	pro-opiomelanocortin-alpha	Mus musculus	102-106
30818765-2	2019	meso-Tetraphenyl-porphyrin chelates (CuII, NiII, CoII) upon reaction wit e.g., itric acid (yellow HNO3, d = 1.52, diluted to 25-50%) in CHCl3 formed a mixture of nitro-derivatives with combined yields of ca 80%.	nitro	162-167	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-53
30867949-1	2019	In the complex cation of the title compound, [Fe(C27H41N10O3)](PF6)2, the tripodal tris-{4-[1-(2-meth-oxy-eth-yl)imidazol-2-yl]-3-aza-but-3-en-yl}amine ligand is coordinated to an FeII ion through the nitro-gen atoms of three imidazole and three imino groups.	nitro	201-206	sperm associated antigen 17	Homo sapiens	63-66
30433782-3	2018	Here, new selective CA IX/XII inhibitors, as analogues of the antitumor phase II drug SLC-0111 are described, namely ureido-substituted benzenesulfonamides appended with a nitro-aromatic moiety to yield an antiproliferative action increased by hypoxia.	nitro	172-177	carbonic anhydrase 9	Homo sapiens	20-25
29995422-2	2019	Nitrostyrene derivative Z-10 is the first identified nitro-ligand of RXRalpha.	nitro	53-58	retinoid X receptor alpha	Mus musculus	69-77
29660194-4	2018	The nitro group of this BIII subporphyrin was reduced with NaBH4 to prepare BIII 5-(aminophenyl)subporphyrin, which was converted into BIII 5-phenylsubporphyrin via the corresponding diazonium salt.	nitro	4-9	calcium voltage-gated channel subunit alpha1 B	Homo sapiens	24-28
29660194-4	2018	The nitro group of this BIII subporphyrin was reduced with NaBH4 to prepare BIII 5-(aminophenyl)subporphyrin, which was converted into BIII 5-phenylsubporphyrin via the corresponding diazonium salt.	nitro	4-9	calcium voltage-gated channel subunit alpha1 B	Homo sapiens	76-80
29660194-4	2018	The nitro group of this BIII subporphyrin was reduced with NaBH4 to prepare BIII 5-(aminophenyl)subporphyrin, which was converted into BIII 5-phenylsubporphyrin via the corresponding diazonium salt.	nitro	4-9	calcium voltage-gated channel subunit alpha1 B	Homo sapiens	76-80
31267866-3	2019	Pharmacophore-based studies revealed that the nitro- or cyano-substituted anilide groups have influenced the activity profiles of non-steroidal AR antagonists, followed by the molecular docking studies with five AR receptors.	nitro	46-51	androgen receptor	Homo sapiens	144-146
30457862-1	2018	Topological analysis reveals stronger bonding for the N-NO2 bond relative to energetic nitramines RDX and HMX and the indication of a trend between this and impact sensitivity of nitro-containing energetic materials is noted.	nitro	179-184	radixin	Homo sapiens	98-101
30631331-5	2018	These two GSTs share 79% identity yet only GSTU25 catalyzes the substitution of a nitro group for sulfur to form 2-glutathionyl-4,6-dinitrotoluene.	nitro	82-87	glutathione S-transferase TAU 25	Arabidopsis thaliana	43-49
30367827-6	2018	Via structural analysis, we observed that nitroaromatic drugs reduced by AOX1 possessed a relatively electron-deficient nitro group.	nitro	42-47	aldehyde oxidase 1	Homo sapiens	73-77
30359520-3	2018	However, various attempts to obtain a double bond via nitrous acid elimination failed because steric repulsion between the newly introduced sp3/sp2 substituent and the nitro group hampered the required anti-coplanar conformation.	nitro	54-59	Sp3 transcription factor	Homo sapiens	140-143
30121001-2	2018	The 2-amino-4H-pyran bearing nitro groups on both the aryl rings showed the highest activity, with an IC50 of 1.98 +- 0.09 microM against acetylcholinesterase (AChE) and 10.62 +- 0.21 microM against butyrylcholinesterase (BChE), the inhibition mechanisms on AChE and BChE receptors were revealed by means of molecular docking simulations.	nitro	29-34	acetylcholinesterase (Cartwright blood group)	Homo sapiens	138-158
30121001-2	2018	The 2-amino-4H-pyran bearing nitro groups on both the aryl rings showed the highest activity, with an IC50 of 1.98 +- 0.09 microM against acetylcholinesterase (AChE) and 10.62 +- 0.21 microM against butyrylcholinesterase (BChE), the inhibition mechanisms on AChE and BChE receptors were revealed by means of molecular docking simulations.	nitro	29-34	acetylcholinesterase (Cartwright blood group)	Homo sapiens	160-164
30121001-2	2018	The 2-amino-4H-pyran bearing nitro groups on both the aryl rings showed the highest activity, with an IC50 of 1.98 +- 0.09 microM against acetylcholinesterase (AChE) and 10.62 +- 0.21 microM against butyrylcholinesterase (BChE), the inhibition mechanisms on AChE and BChE receptors were revealed by means of molecular docking simulations.	nitro	29-34	butyrylcholinesterase	Homo sapiens	199-220
30121001-2	2018	The 2-amino-4H-pyran bearing nitro groups on both the aryl rings showed the highest activity, with an IC50 of 1.98 +- 0.09 microM against acetylcholinesterase (AChE) and 10.62 +- 0.21 microM against butyrylcholinesterase (BChE), the inhibition mechanisms on AChE and BChE receptors were revealed by means of molecular docking simulations.	nitro	29-34	butyrylcholinesterase	Homo sapiens	222-226
30121001-2	2018	The 2-amino-4H-pyran bearing nitro groups on both the aryl rings showed the highest activity, with an IC50 of 1.98 +- 0.09 microM against acetylcholinesterase (AChE) and 10.62 +- 0.21 microM against butyrylcholinesterase (BChE), the inhibition mechanisms on AChE and BChE receptors were revealed by means of molecular docking simulations.	nitro	29-34	acetylcholinesterase (Cartwright blood group)	Homo sapiens	258-262
30121001-2	2018	The 2-amino-4H-pyran bearing nitro groups on both the aryl rings showed the highest activity, with an IC50 of 1.98 +- 0.09 microM against acetylcholinesterase (AChE) and 10.62 +- 0.21 microM against butyrylcholinesterase (BChE), the inhibition mechanisms on AChE and BChE receptors were revealed by means of molecular docking simulations.	nitro	29-34	butyrylcholinesterase	Homo sapiens	267-271
29557543-3	2018	The most promising antibacterial activity was observed for the nitro- and amino-substituted benzimidazole derivatives 3a, 4a, 5a and 5b with MICs 2-8 [Formula: see text].	nitro	63-68	CD99 molecule (Xg blood group)	Homo sapiens	141-149
30153729-3	2018	Specifically, to favor SN2 reaction with a halogen nucleophile over intramolecular cyclization, the nucleophilicity of O-2 oxygen was reduced by incorporation of an adjacent electron withdrawing nitro substituent at N-3.	nitro	195-200	immunoglobulin kappa variable 1D-39	Homo sapiens	119-122
29782802-6	2018	Moreover, the ensemble composed of the Pt single atom and nearby Ni atoms in Pt1/Ni nanocrystals leads to the adsorption configuration of 3-nitrostyrene favorable for the activation of nitro groups, accounting for the high selectivity for 3-vinylaniline.	nitro	140-145	zinc finger protein 77	Homo sapiens	77-80
30093861-5	2018	Among all compounds tested, those with a nitro group and a cyclic pattern structures (FC-30b2, FC-29c, and bozepinib) are the most benefited from the gef gene effect.	nitro	41-46	Rho/Rac guanine nucleotide exchange factor 2	Homo sapiens	150-153
29786423-4	2018	The corresponding limits of detection were 25 mug L-1 for TNT, 30 mug L-1 for DNT, and 10 mug L-1 for both RDX and HMX, using nitro-energetic memory-GC/P(Cz- co-ANI)-Aunano electrodes.	nitro	126-131	immunoglobulin kappa variable 1-16	Homo sapiens	50-53
29473818-1	2018	Nitro-conjugated linoleic acid (NO2-CLA) is formed by metabolic and inflammatory reactions of nitric oxide and nitrite, and represents the most abundant nitro-fatty acid species in humans.	nitro	0-5	selectin P ligand	Homo sapiens	36-39
29504403-1	2018	1,3-Disulfonic acid imidazolium nitrate {[Dsim]NO3} was prepared and characterized as a new ionic liquid and nitrating agent for the ipso-nitration of various arylboronic acids and nitro-Hunsdiecker reaction of different alpha,beta-unsaturated acids and benzoic acid derivatives, by in situ generation of NO2 to give various nitroarenes and nitroolefins without using any cocatalysts and solvents under mild conditions.	nitro	181-186	NBL1, DAN family BMP antagonist	Homo sapiens	47-50
29745962-0	2018	Regioselective nitration of anilines with Fe(NO3)3 9H2O as a promoter and a nitro source.	nitro	76-81	NBL1, DAN family BMP antagonist	Homo sapiens	45-48
28888950-3	2017	AOX is also reported to catalyze the reductive metabolism of nitro-compounds, N-oxides, sulfoxides, isoxazoles, isothiazoles, nitrite and hydroxamic acids.	nitro	61-66	aldehyde oxidase 1	Homo sapiens	0-3
31458502-0	2018	In Situ Preparation of CoP@CdS and Its Catalytic Activity toward Controlling Nitro Reduction under Visible-Light Irradiation.	nitro	77-82	caspase recruitment domain family member 16	Homo sapiens	23-26
29053273-0	2017	Distinguishing Nitro vs Nitrito Coordination in Cytochrome c" Using Vibrational Spectroscopy and Density Functional Theory.	nitro	15-20	D-alanyl-D-alanine carboxypeptidase	Achromobacter xylosoxidans	48-60
28741347-4	2017	FBN-1-3 were composed of a fluorescein analogue and one of three different aromatic nitro groups.	nitro	84-89	fibrillin 1	Homo sapiens	0-5
28929145-2	2017	Intensity changes in nitro vibrations with analyte complexation occur via a mechanism of resonance between the 785 nm laser line and the strongly absorbing charge-transfer chromophore arising from the complex between electron-donating TTF-C[4]P and electron-accepting nitroaromatic explosives.	nitro	21-26	ras homolog family member H	Homo sapiens	235-238
28667876-4	2017	The structure-activity relationship revealed that the electron-withdrawing nitro group substituted at the C6" position of the benzopyran moiety increased the PPARalpha and gamma agonist efficacy.	nitro	75-80	peroxisome proliferator activated receptor alpha	Homo sapiens	158-167
28803055-3	2017	Previous findings showed that aristolochic acid (AA), a major constituent of Aristolochia indica, inhibits Russell"s viper venom LAAO enzyme activity since, AA interacts with DNA and causes genotoxicity, derivatives of this compound were synthesized by replacing the nitro group to reduce toxicity while retaining the inhibitory potency.	nitro	267-272	interleukin 4 induced 1	Homo sapiens	129-133
28841513-5	2017	Compounds with 3,4-dimethoxy groups and meta or para nitro substituents were found to be highly potent inhibitors of ABCG2.	nitro	53-58	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	117-122
28633978-0	2017	Airborne nitro-PAHs induce Nrf2/ARE defense system against oxidative stress and promote inflammatory process by activating PI3K/Akt pathway in A549 cells.	nitro	9-14	NFE2 like bZIP transcription factor 2	Homo sapiens	27-31
28633978-0	2017	Airborne nitro-PAHs induce Nrf2/ARE defense system against oxidative stress and promote inflammatory process by activating PI3K/Akt pathway in A549 cells.	nitro	9-14	AKT serine/threonine kinase 1	Homo sapiens	128-131
28614619-1	2017	A RhII -catalyzed direct and stereospecific N-H- and N-alkyl aziridination of olefins is reported that uses hydroxylamine-O-sulfonic acids as inexpensive, readily available, and nitro group-free aminating reagents.	nitro	178-183	Rh blood group D antigen	Homo sapiens	2-6
28527783-10	2017	Analyses of TIM-38 derivatives revealed that the nitro moiety is vital to P2Y6 receptor inhibition.	nitro	49-54	pyrimidinergic receptor P2Y6	Homo sapiens	74-87
28537428-5	2017	The beta-RDX/Au crystalline films have a high dynamic response, which is characterized by the asymmetric stretching mode of the axial nitro groups, whereas for the beta-RDX/SS crystalline films, the dynamic response was mediated by the -N-NO2 symmetric stretch mode.	nitro	134-139	radixin	Homo sapiens	9-12
28414231-4	2017	As compared with the unsubstituted parent compound, the lone pair of electrons of sulfur substitution plus the intramolecular charge transfer interaction introduced by the nitro moiety lead to an highly efficient T1 (pi,pi*)   S1 (n,pi*) ISC (PhiISC = 100%) and a moderate PhiP (10%).	nitro	172-177	pleckstrin homology domain interacting protein	Homo sapiens	273-277
28189421-3	2017	Among the series, compound 5j (12.46+-0.13muM) with strong electron-withdrawing nitro group on the arylacetamide moiety was identified as the most potent inhibitor of alpha-glucosidase.	nitro	80-85	sucrase-isomaltase	Homo sapiens	167-184
28013041-0	2017	CA3 hippocampal field: Cellular changes and its relation with blood nitro-oxidative stress reveal a balancing function of CA3 area in rats exposed to repetead restraint stress.	nitro	68-73	carbonic anhydrase 3	Rattus norvegicus	0-3
28013041-0	2017	CA3 hippocampal field: Cellular changes and its relation with blood nitro-oxidative stress reveal a balancing function of CA3 area in rats exposed to repetead restraint stress.	nitro	68-73	carbonic anhydrase 3	Rattus norvegicus	122-125
27852777-11	2016	SIGNIFICANCE STATEMENT: We report that nitration (i.e., the irreversible addition of a nitro group) of the Alzheimer-related peptide amyloid-beta (Abeta) favors the stabilization of highly toxic oligomers and inhibits the formation of Abeta fibrils.	nitro	87-92	amyloid beta (A4) precursor protein	Mus musculus	147-152
27988460-5	2017	Molecular docking analysis on iNOS revealed that compounds 5 and 6 bind to the enzyme more efficiently compared to other compounds due to having optimum number of nitro groups, orientations and polarizabilities.	nitro	163-168	nitric oxide synthase 2	Homo sapiens	30-34
28034716-0	2017	Dichotomous effects of isomeric secondary amines containing an aromatic nitrile and nitro group on human aortic smooth muscle cells via inhibition of cystathionine-gamma-lyase.	nitro	84-89	cystathionine gamma-lyase	Homo sapiens	150-175
27923813-2	2017	Nitro-conjugated linoleic acid (NO2-CLA) is preferentially formed, constitutes the most abundant nitrated fatty acid in humans, and contains two carbons that could potentially react with thiols, modulating signaling actions and levels.	nitro	0-5	selectin P ligand	Homo sapiens	36-39
28496472-5	2017	Overall, nitro containing derivatives exerted a higher cytotoxic activity against PC3 cell line and methoxylated derivatives showed an acceptable activity against SKNMC cell line.	nitro	9-14	proprotein convertase subtilisin/kexin type 1	Homo sapiens	82-85
28901858-14	2017	CONCLUSION: The organic nitro compounds, acetyl salicylic acid, insulin and glucose were found to activate PLASENOS in the arterial endothelial cells for a continuous supply of NO to control the chest pain in acute coronary syndrome.	nitro	24-29	insulin	Capra hircus	64-71
29491804-8	2017	Two steps degradation were depicted in the TGA thermograph in nitro containing polymers.	nitro	62-67	T-box transcription factor 1	Homo sapiens	43-46
27852777-11	2016	SIGNIFICANCE STATEMENT: We report that nitration (i.e., the irreversible addition of a nitro group) of the Alzheimer-related peptide amyloid-beta (Abeta) favors the stabilization of highly toxic oligomers and inhibits the formation of Abeta fibrils.	nitro	87-92	amyloid beta (A4) precursor protein	Mus musculus	235-240
27188502-2	2016	Ni(acac)2 and 1,10-phenanthroline showed the best result in the presence of CsF and CuF2 at 120  C. This system tolerated the presence of alkyl, alkoxy, halogen, nitro, cyano, ketone, and ester functional groups.	nitro	162-167	colony stimulating factor 2	Homo sapiens	76-79
27812217-6	2016	Overexpression of NTR2 in wild-type parasites rendered cells hyper-sensitive to bicyclic nitro-compounds, but only marginally to the monocyclic nitro-drugs, nifurtimox and fexinidazole sulfone, known to be activated by a mitochondrial oxygen-insensitive nitroreductase (NTR1).	nitro	89-94	neurotensin receptor 2	Homo sapiens	18-22
27812217-7	2016	Conversely, a double knockout NTR2 null cell line was completely resistant to bicyclic nitro-compounds and only marginally resistant to nifurtimox.	nitro	87-92	neurotensin receptor 2	Homo sapiens	30-34
32263141-2	2016	The nitro-benzyl substrate of HRCNs could be selectively reduced by NTR/NADH that was overexpressed under hypoxic conditions, while it was not responsive to reductive agents (GSH or DTT) commonly existing in biological systems.	nitro	4-9	neurotensin receptor 1	Homo sapiens	68-71
27571070-9	2016	Unlike B[a]P, induction of the aryl hydrocarbon receptor, measured as mRNA expression levels of CYP1A1 and CYP1B1, was low after treatment with polycyclic aromatic hydrocarbon (PAH) nitro-derivatives.	nitro	182-187	aryl hydrocarbon receptor	Homo sapiens	31-56
27571070-9	2016	Unlike B[a]P, induction of the aryl hydrocarbon receptor, measured as mRNA expression levels of CYP1A1 and CYP1B1, was low after treatment with polycyclic aromatic hydrocarbon (PAH) nitro-derivatives.	nitro	182-187	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	96-102
27571070-9	2016	Unlike B[a]P, induction of the aryl hydrocarbon receptor, measured as mRNA expression levels of CYP1A1 and CYP1B1, was low after treatment with polycyclic aromatic hydrocarbon (PAH) nitro-derivatives.	nitro	182-187	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	107-113
27373905-4	2016	We demonstrate, that the luminescence of PSpCz is selectively quenched by nitro-aromatic analytes, e.g. nitrobenzene, 2,4-DNT and TNT.	nitro	74-79	5', 3'-nucleotidase, cytosolic	Homo sapiens	122-125
27063329-6	2016	In particular, large hydrophobic substituents at amine moiety or a nitro at resorcinol skeleton enhanced the inhibitory effect of AAPD even higher than that of sulfamethoxypyridazine, another successful PD-1 inhibitor.	nitro	67-72	programmed cell death 1	Homo sapiens	203-207
27016566-2	2016	Relatively large bulk enrichments in (15)N were observed during biodegradation of RDX via anaerobic ring cleavage (epsilon(15)N = -12.7% +- 0.8%) and anaerobic nitro reduction (epsilon(15)N = -9.9% +- 0.7%), in comparison to smaller effects during biodegradation via aerobic denitration (epsilon(15)N = -2.4% +- 0.2%).	nitro	160-165	radixin	Homo sapiens	82-85
27075703-2	2016	The reactions with 2,3,4-trinitrothiophene offered evidence, by NMR spectroscopy at low temperature, of the formation of new labile Wheland-Meisenheimer intermediates whereas at room temperature stable unexpected products derived from the attack of the nucleophile at C-4 with replacement of the nitro group were isolated.	nitro	28-33	complement C4A (Rodgers blood group)	Homo sapiens	268-271
26531150-0	2015	Benzo[7]annulene-based GluN2B selective NMDA receptor antagonists: Surprising effect of a nitro group in 2-position.	nitro	90-95	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	23-29
26959719-4	2016	Finally, a very interesting, and never observed before, palladium-catalyzed syn beta-elimination occurred, leading to the selective nitro group reduction reaction on the syn-alpha-amino ester functionalized aza-Henry adducts and obtaining more stable optically pure trifluoromethyl conjugated imines.	nitro	132-137	synemin	Homo sapiens	76-79
26959719-4	2016	Finally, a very interesting, and never observed before, palladium-catalyzed syn beta-elimination occurred, leading to the selective nitro group reduction reaction on the syn-alpha-amino ester functionalized aza-Henry adducts and obtaining more stable optically pure trifluoromethyl conjugated imines.	nitro	132-137	synemin	Homo sapiens	170-173
26714298-6	2016	The results showed that oxidation with Cl2 and KMnO4 were more effective than ClO2 and O3 in removing the nitro-based pharmaceuticals.	nitro	106-111	endogenous retrovirus group W member 5	Homo sapiens	39-42
25794030-9	2016	Thirty minutes after occlusion, nitroglycerin ointment USP, 2%(Nitro-Bid) was applied topically to the experimental ears.	nitro	63-68	BH3 interacting domain death agonist	Homo sapiens	69-72
26593383-3	2016	From 1,3,5-tris(N-morpholinyl)benzene and 5-chloro-4-nitrobenzofurazan in the presence of triethylamine an unexpected product derived from the shift of the nitro group from C-4 to C-5 of the electrophile and bearing the nucleophile at position 4 was obtained.	nitro	53-58	complement C4A (Rodgers blood group)	Homo sapiens	173-176
26593383-3	2016	From 1,3,5-tris(N-morpholinyl)benzene and 5-chloro-4-nitrobenzofurazan in the presence of triethylamine an unexpected product derived from the shift of the nitro group from C-4 to C-5 of the electrophile and bearing the nucleophile at position 4 was obtained.	nitro	53-58	complement C5	Homo sapiens	180-183
26716570-6	2016	Reduction was found to comprise two consecutive reactions: a fast four-electron first-order reduction of the nitro-group to the hydroxylamine-intermediate (rate constant=0.28h(-1)) followed by a slower two-electron zero-order reduction resulting in the final amino product (rate constant=6.9muM h(-1)).	nitro	109-114	latexin	Homo sapiens	291-294
26531304-0	2015	A theoretical investigation into the strength of N-NO2 bonds, ring strain and electrostatic potential upon formation of intermolecular H-bonds between HF and the nitro group in nitrogen heterocyclic rings C n H2n N-NO2 (n = 2-5), RDX and HMX.	nitro	162-167	membrane frizzled-related protein	Homo sapiens	49-54
26531304-0	2015	A theoretical investigation into the strength of N-NO2 bonds, ring strain and electrostatic potential upon formation of intermolecular H-bonds between HF and the nitro group in nitrogen heterocyclic rings C n H2n N-NO2 (n = 2-5), RDX and HMX.	nitro	162-167	membrane frizzled-related protein	Homo sapiens	213-218
26531304-1	2015	Changes in N-NO2 bond strength, ring strain energy and electrostatic potential upon formation of intermolecular H-bonds between HF and the nitro group in nitrogen heterocyclic rings C n H2n N-NO2 (n = 2-5), RDX and HMX were investigated using DFT-B3LYP and MP2(full) methods with the 6-311++G(2df,2p) and aug-cc-pVTZ basis sets.	nitro	139-144	membrane frizzled-related protein	Homo sapiens	11-16
26531304-1	2015	Changes in N-NO2 bond strength, ring strain energy and electrostatic potential upon formation of intermolecular H-bonds between HF and the nitro group in nitrogen heterocyclic rings C n H2n N-NO2 (n = 2-5), RDX and HMX were investigated using DFT-B3LYP and MP2(full) methods with the 6-311++G(2df,2p) and aug-cc-pVTZ basis sets.	nitro	139-144	membrane frizzled-related protein	Homo sapiens	190-195
26531304-1	2015	Changes in N-NO2 bond strength, ring strain energy and electrostatic potential upon formation of intermolecular H-bonds between HF and the nitro group in nitrogen heterocyclic rings C n H2n N-NO2 (n = 2-5), RDX and HMX were investigated using DFT-B3LYP and MP2(full) methods with the 6-311++G(2df,2p) and aug-cc-pVTZ basis sets.	nitro	139-144	radixin	Homo sapiens	207-210
26531304-1	2015	Changes in N-NO2 bond strength, ring strain energy and electrostatic potential upon formation of intermolecular H-bonds between HF and the nitro group in nitrogen heterocyclic rings C n H2n N-NO2 (n = 2-5), RDX and HMX were investigated using DFT-B3LYP and MP2(full) methods with the 6-311++G(2df,2p) and aug-cc-pVTZ basis sets.	nitro	139-144	tryptase pseudogene 1	Homo sapiens	257-260
26043946-3	2015	Here we show that a simple replacement of cyano for nitro at the 4 position to give compound 4b ("p-cyano-PABA/NO") has the dual effect of slowing the undesired side reactions while enhancing the proportion of NO release and arylating activity on catalysis by GSTP1.	nitro	52-57	glutathione S-transferase pi 1	Homo sapiens	260-265
26094119-4	2015	The nitro derivative showed the highest activity of the series with an IC50 = 17.24 muM, and comparable potency to the 3,4-benzodioxole ester and n-hexyl carbamate derivatives.	nitro	4-9	latexin	Homo sapiens	84-87
26370130-1	2015	Interpretation of the experiments showing that the Ras-GAP protein complex maintains activity in guanosine triphosphate (GTP) hydrolysis upon replacement of Glu61 in Ras with its unnatural nitro analog, NGln, is an important issue for understanding details of chemical transformations at the enzyme active site.	nitro	189-194	RAS p21 protein activator 1	Homo sapiens	51-58
26265155-3	2015	This work presents an ultra-high performance liquid chromatography-atmospheric pressure photoionization-tandem mass spectrometry (UHPLC-APPI-MS/MS) method for simultaneous analysis of 20 PAHs and nine nitro-PAHs.	nitro	201-206	amyloid beta precursor protein	Homo sapiens	136-140
26265155-10	2015	This fast, sensitive, and reliable method is the first UHPLC-APPI-MS/MS method capable of simultaneously analyzing 29 environmentally and toxicologically important PAHs and nitro-PAHs.	nitro	173-178	amyloid beta precursor protein	Homo sapiens	61-65
26135808-5	2015	Furthermore, NO2-PTPA afforded nonvolatile WORM memory behavior attributed to the charge could be trapped into the nonconjugated nitro group even though the dipole moment and electron-withdrawing capability of nitro group were weaker than cyanovinyl groups.	nitro	129-134	protein phosphatase 2 phosphatase activator	Homo sapiens	17-21
25970048-2	2015	The barrier heights for the roaming transition states between nitro (RNO2) and nitrite (RONO) isomerization reactions and those for the concerted HONO and HNO2 elimination reactions from RNO2 and RONO, affect the pressure dependences of the product-specific rate coefficients.	nitro	62-67	NLR family pyrin domain containing 12	Homo sapiens	69-73
26135808-5	2015	Furthermore, NO2-PTPA afforded nonvolatile WORM memory behavior attributed to the charge could be trapped into the nonconjugated nitro group even though the dipole moment and electron-withdrawing capability of nitro group were weaker than cyanovinyl groups.	nitro	210-215	protein phosphatase 2 phosphatase activator	Homo sapiens	17-21
25819320-7	2015	From the MEP plot, the negative charge covers the nitro group and the positive region is over the hydroxyl group and N-H part of the imidazole ring.	nitro	50-55	neurolysin	Homo sapiens	9-12
25712867-7	2015	Nitro-oxidative stress and cell death in NOS-3 overexpressing cells occurred with the expression increase of pro-apoptotic genes and a higher expression/activity of the enzymes adrenodoxin reductase mitochondrial (AR) and cathepsin D (CatD).	nitro	0-5	nitric oxide synthase 3	Homo sapiens	41-46
25795708-3	2015	Here, we report that a class of nitrostyrene derivatives bind to RXRalpha by a unique mechanism, of which the nitro group of nitrostyrene derivatives and Cys432 of RXRalpha are required for binding.	nitro	32-37	retinoid X receptor alpha	Homo sapiens	65-73
25795708-3	2015	Here, we report that a class of nitrostyrene derivatives bind to RXRalpha by a unique mechanism, of which the nitro group of nitrostyrene derivatives and Cys432 of RXRalpha are required for binding.	nitro	32-37	retinoid X receptor alpha	Homo sapiens	164-172
25712867-7	2015	Nitro-oxidative stress and cell death in NOS-3 overexpressing cells occurred with the expression increase of pro-apoptotic genes and a higher expression/activity of the enzymes adrenodoxin reductase mitochondrial (AR) and cathepsin D (CatD).	nitro	0-5	ferredoxin reductase	Homo sapiens	177-198
25712867-7	2015	Nitro-oxidative stress and cell death in NOS-3 overexpressing cells occurred with the expression increase of pro-apoptotic genes and a higher expression/activity of the enzymes adrenodoxin reductase mitochondrial (AR) and cathepsin D (CatD).	nitro	0-5	cathepsin D	Homo sapiens	222-233
25712867-7	2015	Nitro-oxidative stress and cell death in NOS-3 overexpressing cells occurred with the expression increase of pro-apoptotic genes and a higher expression/activity of the enzymes adrenodoxin reductase mitochondrial (AR) and cathepsin D (CatD).	nitro	0-5	cathepsin D	Homo sapiens	235-239
25630891-1	2015	The highly enantioselective organocatalytic addition of ethyl nitroacetate to isatin-derived N-Boc ketimines (Boc = tert-butoxycarbonyl), followed by the removal of the nitro group, is described.	nitro	62-67	BOC cell adhesion associated, oncogene regulated	Homo sapiens	95-98
25633645-7	2015	Quantum chemistry predicts the planar structure of both syn- and anti- stable conformations with close energies and weak interaction between internal rotations of nitro and vinyl groups.	nitro	163-168	synemin	Homo sapiens	56-59
25630891-1	2015	The highly enantioselective organocatalytic addition of ethyl nitroacetate to isatin-derived N-Boc ketimines (Boc = tert-butoxycarbonyl), followed by the removal of the nitro group, is described.	nitro	62-67	BOC cell adhesion associated, oncogene regulated	Homo sapiens	110-113
26528062-12	2015	CONCLUSION: In patients with noncirrhotic and cirrhotic portal hypertension a significant systemic nitro-oxidative stress was found, correlated with an increase of VEGF.	nitro	99-104	vascular endothelial growth factor A	Homo sapiens	164-168
25532905-3	2015	In general, the amino derivatives (4-6) proved to be more selective against MAO-B than the nitro derivatives (1-3).	nitro	91-96	monoamine oxidase B	Homo sapiens	76-81
25496238-2	2015	By using this mild and economical methodology, syntheses of beta-(2/4-nitroaryl)-indoles with sensitive functionalities such as bromo, iodo, cyano, and nitro were achieved chemo- and regioselectively.	nitro	70-75	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	60-67
26461400-0	2014	Mapping nitro-tyrosine modifications in fibrinogen by mass spectrometry as a biomarker for inflammatory disease.	nitro	8-13	fibrinogen beta chain	Homo sapiens	40-50
25181676-8	2014	The most potent inhibitors among the two series were nitro substituted compounds 1i and 2i with Ki values of ~1.1x10(-9)M and 19.5x10(-8)M for cathepsin B and Ki values of ~5.19x10(-8)M and 9.8x10(-7)M for cathepsin H, respectively.	nitro	53-58	cathepsin B	Homo sapiens	143-154
25181676-8	2014	The most potent inhibitors among the two series were nitro substituted compounds 1i and 2i with Ki values of ~1.1x10(-9)M and 19.5x10(-8)M for cathepsin B and Ki values of ~5.19x10(-8)M and 9.8x10(-7)M for cathepsin H, respectively.	nitro	53-58	cathepsin H	Homo sapiens	206-217
25259515-3	2014	Particularly, compounds bearing electron withdrawing groups such as nitro substituted compound 3j (IC50 = 0.001 muM) and fluoro substituted compound 3i (IC50 = 0.003 muM) showed comparatively more cytotoxic potential than standard drugs against lung cancer cell line (A549).	nitro	68-73	latexin	Homo sapiens	112-115
25259515-3	2014	Particularly, compounds bearing electron withdrawing groups such as nitro substituted compound 3j (IC50 = 0.001 muM) and fluoro substituted compound 3i (IC50 = 0.003 muM) showed comparatively more cytotoxic potential than standard drugs against lung cancer cell line (A549).	nitro	68-73	latexin	Homo sapiens	166-169
25329713-3	2014	In previous studies, these two products were observed in the gas-phase reaction between N2O5/NO3/NO2 and their parent polycyclic aromatic hydrocarbons (PAHs), while the heterogeneous reaction generated other nitro-PAH isomers (1, 3, 7, 8-NFL and 1-NPY) (Atkinson et al.	nitro	208-213	NBL1, DAN family BMP antagonist	Homo sapiens	93-96
25329713-3	2014	In previous studies, these two products were observed in the gas-phase reaction between N2O5/NO3/NO2 and their parent polycyclic aromatic hydrocarbons (PAHs), while the heterogeneous reaction generated other nitro-PAH isomers (1, 3, 7, 8-NFL and 1-NPY) (Atkinson et al.	nitro	208-213	neurofilament light chain	Homo sapiens	238-241
25329713-3	2014	In previous studies, these two products were observed in the gas-phase reaction between N2O5/NO3/NO2 and their parent polycyclic aromatic hydrocarbons (PAHs), while the heterogeneous reaction generated other nitro-PAH isomers (1, 3, 7, 8-NFL and 1-NPY) (Atkinson et al.	nitro	208-213	neuropeptide Y	Homo sapiens	248-251
25329713-6	2014	Under low humidity (0.5% RH) or a relatively high ratio of [NO3]/[N2O5], 2-NFL and 2-NPY were observed as the major nitro-FL isomers for the first time in the heterogeneous reaction.	nitro	116-121	neuropeptide Y	Homo sapiens	85-88
25156478-6	2014	Intramolecular N   O and Hal   O (Hal=F (1), Br (2), I (3)) interactions, both competitors in terms of the orientation of the nitro groups by rotation about the C-N bonds, lead to a propeller-type twisting of these groups favoring the mentioned interactions.	nitro	126-131	histidine ammonia-lyase	Homo sapiens	25-28
25156478-6	2014	Intramolecular N   O and Hal   O (Hal=F (1), Br (2), I (3)) interactions, both competitors in terms of the orientation of the nitro groups by rotation about the C-N bonds, lead to a propeller-type twisting of these groups favoring the mentioned interactions.	nitro	126-131	histidine ammonia-lyase	Homo sapiens	34-37
24992467-4	2014	DFT calculations of the stable tautomer of selected (Ph)ImC analogues suggested a relationship between the HOMO-LUMO gap and Phi and explained the loss of fluorescence in the nitro analogue.	nitro	175-180	glucose-6-phosphate isomerase	Homo sapiens	125-128
25087047-2	2014	The evaluation of their inhibitory potency toward Pim kinases demonstrated that the nitro series could be considered as an interesting starting point for the development of new Pim kinase inhibitors, especially Pim-3.	nitro	84-89	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	50-53
25087047-2	2014	The evaluation of their inhibitory potency toward Pim kinases demonstrated that the nitro series could be considered as an interesting starting point for the development of new Pim kinase inhibitors, especially Pim-3.	nitro	84-89	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	177-180
25087047-2	2014	The evaluation of their inhibitory potency toward Pim kinases demonstrated that the nitro series could be considered as an interesting starting point for the development of new Pim kinase inhibitors, especially Pim-3.	nitro	84-89	Pim-3 proto-oncogene, serine/threonine kinase	Homo sapiens	211-216
25087047-3	2014	A preferential binding mode was suggested by molecular modeling experiments for nitro series and Pim-1/Pim-3 ATP-binding sites.	nitro	80-85	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	97-102
25087047-3	2014	A preferential binding mode was suggested by molecular modeling experiments for nitro series and Pim-1/Pim-3 ATP-binding sites.	nitro	80-85	Pim-3 proto-oncogene, serine/threonine kinase	Homo sapiens	103-108
24780403-5	2014	The most potent inhibitors among the three series were nitro substituted compounds 1g, 2g and 3g with Ki values of ~6.18x10(-8) M, 4.8x10(-7) M and 7.85x10(-7) M for cathepsin B and Ki values of ~2.8x10(-7) M, 31.8x10(-6) M and 33.7x10(-6) M for cathepsin H, respectively.	nitro	55-60	cathepsin B	Homo sapiens	166-177
24780403-5	2014	The most potent inhibitors among the three series were nitro substituted compounds 1g, 2g and 3g with Ki values of ~6.18x10(-8) M, 4.8x10(-7) M and 7.85x10(-7) M for cathepsin B and Ki values of ~2.8x10(-7) M, 31.8x10(-6) M and 33.7x10(-6) M for cathepsin H, respectively.	nitro	55-60	cathepsin H	Homo sapiens	246-257
25145416-4	2014	Gas chromatography with an electron capture detector is an instrumentation configuration sensitive to nitro-energetics, such as TNT and RDX, due to their relatively high electron affinity.	nitro	102-107	chromosome 16 open reading frame 82	Homo sapiens	128-131
25145416-4	2014	Gas chromatography with an electron capture detector is an instrumentation configuration sensitive to nitro-energetics, such as TNT and RDX, due to their relatively high electron affinity.	nitro	102-107	radixin	Homo sapiens	136-139
24507930-9	2014	Thin-layer UV-visible spectroelectrochemical measurements in CH2Cl2, 0.1 M TBAP demonstrate the occurrence of an equilibrium between a Co(III) pi-anion radical and a Co(II) derivative with an uncharged macrocycle after the first controlled potential reduction of the nitro-substituted corroles.	nitro	267-272	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-172
25313764-8	2014	RESULTS: Both nitro/methoxy (Group I) and halogen substituted propandiones at ortho, meta and para positions (Group II) showed a moderate increase in caspase-3 activity by 1.5- to 3.3-fold as compared with controls.	nitro	14-19	caspase 3	Homo sapiens	150-159
24507930-9	2014	Thin-layer UV-visible spectroelectrochemical measurements in CH2Cl2, 0.1 M TBAP demonstrate the occurrence of an equilibrium between a Co(III) pi-anion radical and a Co(II) derivative with an uncharged macrocycle after the first controlled potential reduction of the nitro-substituted corroles.	nitro	267-272	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	135-142
24840643-2	2014	Here we report a combined high-pressure diffraction and computational study of the structural response to methanol uptake at high pressure on a scandium terephthalate MOF (Sc2BDC3, BDC = 1,4-benzenedicarboxylate) and its nitro-functionalized derivative (Sc2(NO2-BDC)3) and compare it to direct compression behavior in a nonpenetrative hydrostatic fluid, Fluorinert-77.	nitro	221-226	lysine acetyltransferase 8	Homo sapiens	167-170
24860331-4	2014	One H atom of the phenyl ring and of the NMe2 group associate with the O atoms of the nitro group, giving chains along the a- and b-axis directions.	nitro	86-91	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	41-45
24697240-2	2014	Most organic functional groups are tolerated by zinc organometallic reagents, and Csp(2)-centered magnesium organometallic reagents are compatible with important functional groups, such as the ester, aryl ketone, nitro, cyano, and amide functions.	nitro	213-218	regulator of calcineurin 2	Homo sapiens	82-87
24410114-2	2014	Transformation of one of the products to beta(2,2)-amino ester and tetrahydro-beta-carboline through nitro reduction and sequential Pictet-Spengler cyclization was exemplified.	nitro	101-106	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	41-49
23436231-4	2013	Specifically, the question remains: do such adducts have a nitro- (RNO2) or nitrosoxy- (RONO) moiety, or are both isomers present in the adduct population?	nitro	59-64	NLR family pyrin domain containing 12	Homo sapiens	67-71
24614897-5	2014	We found an increased production of methylglyoxal (MG), a toxic byproduct of the inefficient nitro-TPI function.	nitro	93-98	triosephosphate isomerase 1	Homo sapiens	99-102
24043545-7	2013	The results show that the two components TNT and CL-20 are connected mainly by nitro-aromatic interactions, and nitro-nitro interactions.	nitro	79-84	epithelial membrane protein 1	Homo sapiens	49-54
24043545-7	2013	The results show that the two components TNT and CL-20 are connected mainly by nitro-aromatic interactions, and nitro-nitro interactions.	nitro	112-117	epithelial membrane protein 1	Homo sapiens	49-54
24043545-7	2013	The results show that the two components TNT and CL-20 are connected mainly by nitro-aromatic interactions, and nitro-nitro interactions.	nitro	112-117	epithelial membrane protein 1	Homo sapiens	49-54
24900588-3	2013	Structure-activity relationship studies confirmed that the pharmacophore of these novel AR antagonists is distinct from the nitro- or cyano-substituted anilide substructure of other nonsteroidal AR antagonists.	nitro	124-129	androgen receptor	Homo sapiens	88-90
23351115-7	2013	KEY RESULTS: One indolecarboxamide (75) with a nitro substituent on position R7 of the aromatic ring displayed an equal preference for the Galphai and beta-arrestin2 pathway and was classified as unbiased hH4R ligand.	nitro	47-52	arrestin beta 2	Homo sapiens	151-165
23351115-7	2013	KEY RESULTS: One indolecarboxamide (75) with a nitro substituent on position R7 of the aromatic ring displayed an equal preference for the Galphai and beta-arrestin2 pathway and was classified as unbiased hH4R ligand.	nitro	47-52	histamine receptor H4	Homo sapiens	205-209
23490159-3	2013	Among all the designed compounds, compound 18 bearing a nitro substituent exhibited more potent in vitro anticancer activities with IC50 values of 0.7+-0.2, 30.0+-1.2, 18.3+-1.4 muM, respectively, which was superior to the positive control.	nitro	56-61	latexin	Homo sapiens	178-181
23078107-2	2012	The formation of SAMs and their quality are investigated as a function of the position of the nitro substituent(s) on the aromatic ring.	nitro	94-99	methionine adenosyltransferase 1A	Homo sapiens	17-21
23697103-5	2013	P-2, P-3 and P-4 have varying degrees of quenching after nitro joining.	nitro	57-62	exosome component 10	Homo sapiens	0-16
22955424-1	2013	The changes of bond dissociation energy (BDE) in the C-NO(2) bond and nitro group charge upon the formation of the intermolecular hydrogen-bonding interaction between HF and the nitro group of 14 kinds of nitrotriazoles or methyl derivatives were investigated using the B3LYP and MP2(full) methods with the 6-311++G**, 6-311++G(2df,2p) and aug-cc-pVTZ basis sets.	nitro	178-183	tryptase pseudogene 1	Homo sapiens	280-283
23270469-2	2013	A Li-based MOF can detect an explosive aromatic compound containing nitro groups as an explosophore, by showing a dramatic color change with concurrent luminescence quenching in the solid state.	nitro	68-73	lysine acetyltransferase 8	Homo sapiens	11-14
23476457-2	2013	Further, the N-H bond is syn to the ortho-nitro group in the sulfonyl benzene ring and also syn to both the ortho- and meta-Cl atoms in the aniline ring.	nitro	42-47	synemin	Homo sapiens	25-28
23476457-2	2013	Further, the N-H bond is syn to the ortho-nitro group in the sulfonyl benzene ring and also syn to both the ortho- and meta-Cl atoms in the aniline ring.	nitro	42-47	synemin	Homo sapiens	92-95
23233058-9	2013	Moreover, nitro-TPI aggregates interact with tau protein inducing the intraneuronal aggregation of tau.	nitro	10-15	triosephosphate isomerase 1	Homo sapiens	16-19
23233058-9	2013	Moreover, nitro-TPI aggregates interact with tau protein inducing the intraneuronal aggregation of tau.	nitro	10-15	microtubule associated protein tau	Homo sapiens	45-48
23233058-9	2013	Moreover, nitro-TPI aggregates interact with tau protein inducing the intraneuronal aggregation of tau.	nitro	10-15	microtubule associated protein tau	Homo sapiens	99-102
23171305-8	2012	The main transformation pathway of methoxyphenols is the NO3 electrophilic addition, followed by H-abstraction and nitro-substituted processes.	nitro	115-120	NBL1, DAN family BMP antagonist	Homo sapiens	57-60
22794275-1	2012	Tetrahydroquinolines (THQs), a new class of nonsteroidal selective androgen receptor (AR) modulators, have two indispensable functional groups, that is, a hydroxyl group for AR binding and a nitro group for agonistic activity.	nitro	191-196	androgen receptor	Homo sapiens	86-88
23012404-6	2012	In agreement with these observations, we demonstrate that TFAM has the capacity to induce negative supercoils in DNA, and, using the recently developed nucleobase analog FRET-pair tC(O)-tC(nitro), we find that TFAM distorts significantly the DNA structure.	nitro	189-194	transcription factor A, mitochondrial	Homo sapiens	58-62
23012404-6	2012	In agreement with these observations, we demonstrate that TFAM has the capacity to induce negative supercoils in DNA, and, using the recently developed nucleobase analog FRET-pair tC(O)-tC(nitro), we find that TFAM distorts significantly the DNA structure.	nitro	189-194	transcription factor A, mitochondrial	Homo sapiens	210-214
21720886-0	2012	Structural features underlying the selectivity of the kinase inhibitors NBC and dNBC: role of a nitro group that discriminates between CK2 and DYRK1A.	nitro	96-101	Calcium-dependent protein kinase 6	Zea mays	135-138
22905002-1	2012	In the title compound, C(12)H(9)ClN(2)O(4)S, the N-H bond in the -SO(2)-NH- segment is syn to both the ortho-nitro group in the sulfonyl-benzene ring and the ortho-Cl atom in the aniline ring.	nitro	109-114	synemin	Homo sapiens	87-90
22770527-4	2012	The two TNT isomers differ by an internal rotation of the methyl group, while the four conformers of RDX differ by the arrangements of the nitro group relative to the ring.	nitro	139-144	radixin	Homo sapiens	101-104
21904813-0	2012	A B3LYP and MP2(full) theoretical investigation into explosive sensitivity upon the formation of the molecule-cation interaction between the nitro group of 3,4-dinitropyrazole and H+, Li+, Na+, Be2+ or Mg2+.	nitro	141-146	tryptase pseudogene 1	Homo sapiens	12-15
21904813-1	2012	The explosive sensitivity upon the formation of molecule-cation interaction between the nitro group of 3,4-dinitropyrazole (DNP) and H(+), Li(+), Na(+), Be(2+) or Mg(2+) has been investigated using the B3LYP and MP2(full) methods with the 6-311++G** and 6-311++G(2df,2p) basis sets.	nitro	88-93	tryptase pseudogene 1	Homo sapiens	212-215
21370283-3	2011	AAI binds to the active site of NQO1 indicating that the binding orientation allows for direct hydride transfer (i.e., two electron reductions) to the nitro group of AAI.	nitro	151-156	NAD(P)H quinone dehydrogenase 1	Homo sapiens	32-36
22072032-1	2012	Highly purified preparations of thymidylate synthase, isolated from calf thymus, and L1210 parental and FdUrd-resistant cells, were found to be nitrated, as indicated by a specific reaction with anti-nitro-tyrosine antibodies, suggesting this modification to appear endogenously in normal and tumor tissues.	nitro	200-205	thymidylate synthetase	Bos taurus	32-52
23167798-6	2012	Results show that quinone-derivatives that bear two electroactive groups (namely quinone and nitro) exhibit the highest inhibitory activity (Hsp90 cleavage and cell death).	nitro	93-98	heat shock protein 90 alpha family class A member 1	Homo sapiens	141-146
21623630-2	2011	The indolic ring system was substituted at the C-4 to C-7 positions either by a bromine atom or by nitro or amino groups.	nitro	99-104	complement C4A (Rodgers blood group)	Homo sapiens	47-50
21623630-2	2011	The indolic ring system was substituted at the C-4 to C-7 positions either by a bromine atom or by nitro or amino groups.	nitro	99-104	complement C7	Homo sapiens	54-57
21674491-2	2012	By reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides, peroxiredoxins (Prdxs) represent a major potential protective barrier against nitro-oxidative insults in the brain.	nitro	152-157	peroxiredoxin 1	Mus musculus	74-88
22162208-0	2012	beta-Carotene and lycopene affect endothelial response to TNF-alpha reducing nitro-oxidative stress and interaction with monocytes.	nitro	77-82	tumor necrosis factor	Homo sapiens	58-67
23353840-14	2012	For the CYP1B1:AAI complex, however, any hydrogen bonding of the nitro-group of AAI is prevented as Ser122/Thr124 residues are in CYP1B1 protein replaced by hydrophobic residue Ala133.	nitro	65-70	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	8-14
23353840-14	2012	For the CYP1B1:AAI complex, however, any hydrogen bonding of the nitro-group of AAI is prevented as Ser122/Thr124 residues are in CYP1B1 protein replaced by hydrophobic residue Ala133.	nitro	65-70	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	130-136
23353840-18	2012	The absence of a suitable proton donor in the AAI-CYP1B1 binary complex could be the key difference, as the nitro group is in this complex surrounded only by the hydrophobic residues with potential hydrogen donors not closer than 5 A.	nitro	108-113	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	50-56
21162566-8	2011	Differences in the quenching rate constants of the triplet by water and phenols suggest a strong hydrogen-bond interaction with the nitro group in the C-2 position, which provides for radiationless deactivation routes.	nitro	132-137	complement C2	Homo sapiens	151-154
21284394-0	2011	Enantioselective conjugate addition nitro-Mannich reactions: solvent controlled synthesis of acyclic anti- and syn-beta-nitroamines with three contiguous stereocenters.	nitro	36-41	synemin	Homo sapiens	80-83
21109332-2	2011	The latter, together with the respective nitro derivatives obtained by oxidation, have been characterised as weak inhibitors of rat dihydroorotate dehydrogenase (DHODH).	nitro	41-46	dihydroorotate dehydrogenase (quinone)	Rattus norvegicus	132-160
21142121-2	2011	PTN introduces a nitro group in the ortho position of the phenolic hydroxyl group of tyrosine residues.	nitro	17-22	pleiotrophin	Homo sapiens	0-3
21109332-2	2011	The latter, together with the respective nitro derivatives obtained by oxidation, have been characterised as weak inhibitors of rat dihydroorotate dehydrogenase (DHODH).	nitro	41-46	dihydroorotate dehydrogenase (quinone)	Rattus norvegicus	162-167
20071057-4	2010	In this study, two nitro derivatives of rosmarinic acid synthesized previously, 6"-nitro and 6",6""-dinitrorosmarinic acids, are proposed as aldose reductase inhibitors.	nitro	19-24	aldo-keto reductase family 1 member B	Homo sapiens	141-157
20097754-5	2010	In contrast, nitro derivatives of unsaturated fatty acids (NO(2)-FA) are endogenous products of nitric oxide ((*)NO) and nitrite (NO(2)(-))-mediated redox reactions that activate PPARgamma at nanomolar concentrations.	nitro	13-18	peroxisome proliferator activated receptor gamma	Mus musculus	179-188
22167209-11	2011	One of the reasons causing this phenomenon is a lower efficiency of NQO1 to reduce AAII than AAI we found in this work; although both AAI and AAII are bound with similar binding affinities to the NQO1 active site, the binding orientation of AAII in the active site of NQO1 does not favor the effective reduction of its nitro group.	nitro	319-324	NAD(P)H quinone dehydrogenase 1	Homo sapiens	68-72
22167209-11	2011	One of the reasons causing this phenomenon is a lower efficiency of NQO1 to reduce AAII than AAI we found in this work; although both AAI and AAII are bound with similar binding affinities to the NQO1 active site, the binding orientation of AAII in the active site of NQO1 does not favor the effective reduction of its nitro group.	nitro	319-324	NAD(P)H quinone dehydrogenase 1	Homo sapiens	196-200
22167209-11	2011	One of the reasons causing this phenomenon is a lower efficiency of NQO1 to reduce AAII than AAI we found in this work; although both AAI and AAII are bound with similar binding affinities to the NQO1 active site, the binding orientation of AAII in the active site of NQO1 does not favor the effective reduction of its nitro group.	nitro	319-324	NAD(P)H quinone dehydrogenase 1	Homo sapiens	196-200
20131084-7	2010	A low degree of nitro group removal resulting in the formation of pentachlorobenzene (PeCB) was also observed in the control culture when amended with 13 muM PCNB.	nitro	16-21	latexin	Homo sapiens	154-157
20682995-4	2010	The main findings were that the nitro-oxy derivative behaved like celecoxib in HT-29 cells in terms of COX-2 and ERK/MAPK inhibition, as well as induction of apoptosis, while the benzyl nitrate had no such effects.	nitro	32-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
20682995-4	2010	The main findings were that the nitro-oxy derivative behaved like celecoxib in HT-29 cells in terms of COX-2 and ERK/MAPK inhibition, as well as induction of apoptosis, while the benzyl nitrate had no such effects.	nitro	32-37	mitogen-activated protein kinase 1	Homo sapiens	113-116
20188776-3	2010	ACE inhibitors are reported to induce nitric oxide (NO)-dependent vasorelaxation by elevating the endogenous bradykinin level; however, the vasorelaxation induced by 10microM of rapakinin was blocked only insignificantly by HOE140 or N(G)-nitro-l-arginine methyl ester (l-NAME), antagonists of bradykinin B(2) receptor and an inhibitor of NO synthase, respectively.	nitro	239-244	angiotensin I converting enzyme	Rattus norvegicus	0-3
20218689-0	2010	Heterobimetallic transition metal/rare earth metal bifunctional catalysis: a Cu/Sm/Schiff base complex for syn-selective catalytic asymmetric nitro-Mannich reaction.	nitro	142-147	synemin	Homo sapiens	107-110
20218689-1	2010	The full details of a catalytic asymmetric syn-selective nitro-Mannich reaction promoted by heterobimetallic Cu/Sm/dinucleating Schiff base complexes are described, demonstrating the effectiveness of the heterobimetallic transition metal/rare earth metal bifunctional catalysis.	nitro	57-62	synemin	Homo sapiens	43-46
20218689-2	2010	The first-generation system prepared from Cu(OAc)(2)/Sm(O-iPr)(3)/Schiff base 1a = 1:1:1 with an achiral phenol additive was partially successful for achieving the syn-selective catalytic asymmetric nitro-Mannich reaction.	nitro	199-204	synemin	Homo sapiens	164-167
20071057-5	2010	Docking studies of the nitro derivatives have been carried out in the active site of aldose reductase.	nitro	23-28	aldo-keto reductase family 1 member B	Homo sapiens	85-101
20858976-11	2010	Altogether, our results support a key role of nitro-oxidative stress in the neuronal damage induced by Abeta fibrils.	nitro	46-51	amyloid beta precursor protein	Homo sapiens	103-108
20025965-3	2010	However, subsequent mass spectrometric and amino acid analyses of purified SCOT indicated that tryptophan 372, rather than a tyrosine residue, was the actual site of simultaneous additions of nitro and hydroxy groups.	nitro	192-197	3-oxoacid CoA transferase 1	Rattus norvegicus	75-79
19682443-6	2009	In particular, the analogue displaying two nitro-oxy functions fully mimicked the known inhibitory properties of celecoxib, including inhibition of COX-2, as well as of ERK/MAPK and beta-catenin signalling pathways.	nitro	43-48	prostaglandin-endoperoxide synthase 2	Homo sapiens	148-153
19682443-6	2009	In particular, the analogue displaying two nitro-oxy functions fully mimicked the known inhibitory properties of celecoxib, including inhibition of COX-2, as well as of ERK/MAPK and beta-catenin signalling pathways.	nitro	43-48	catenin beta 1	Homo sapiens	182-194
19711927-5	2009	Catalytic reduction of the nitro group followed by reaction with NBS resulted in the formation of the required pentacyclic indoline framework of the target alkaloid.	nitro	27-32	nibrin	Homo sapiens	65-68
19391582-3	2009	Human liver aldehyde oxidase reduces the nitro substituent of CLO to nitroso much more rapidly than it does that of TMX.	nitro	41-46	aldehyde oxidase 1	Homo sapiens	12-28
19376645-5	2009	Based on the spectra analyzed by gas chromatograph/mass spectrometer (GC/MS), it is proposed that initial denitration of 2,4-DNT and/or 2,6-DNT gives rise to formation of o-mononitrotoluene, which undergoes the cleavage of nitro group into toluene, followed by oxidation of methyl group to benzoic acid and subsequent decarboxylation.	nitro	177-182	5', 3'-nucleotidase, cytosolic	Homo sapiens	125-128
19376645-5	2009	Based on the spectra analyzed by gas chromatograph/mass spectrometer (GC/MS), it is proposed that initial denitration of 2,4-DNT and/or 2,6-DNT gives rise to formation of o-mononitrotoluene, which undergoes the cleavage of nitro group into toluene, followed by oxidation of methyl group to benzoic acid and subsequent decarboxylation.	nitro	177-182	5', 3'-nucleotidase, cytosolic	Homo sapiens	140-143
19882863-8	2009	The nitro compounds showing the properties of NO donors (RNO2) were determined as the substances that acquire the properties of DNIC in the presence of ferrous iron and thiols.	nitro	4-9	NLR family pyrin domain containing 12	Homo sapiens	57-61
19441779-3	2009	Relative stereocontrol was achieved between C-2 and C-3 by kinetic protonation of a nitronate or by equilibration of the nitro group under thermodynamic control.	nitro	84-89	complement C2	Homo sapiens	44-47
19441779-3	2009	Relative stereocontrol was achieved between C-2 and C-3 by kinetic protonation of a nitronate or by equilibration of the nitro group under thermodynamic control.	nitro	84-89	complement C3	Homo sapiens	52-55