PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
18467771-2	2007	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) of pathogenic protozoa Trichomonas vaginalis (TvGAPDH) is an attractive drug target since this parasite lacks functional citric acid cycle and is dependent solely on glycolysis for its energy requirements.	Citric Acid	170-181	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	42-47
17390701-7	2007	Results showed the best formulation (F-5) to closely corresponded to extra design checkpoint formulation by a similarity (f2) value of 95.41 and capsules made with 15% w/v EC, 50 mg sodium chloride, 8% w/v glycerol and 30 mg citric acid (F-11), to achieve therapeutic concentration within first hour of dissolution not observed with any other formulations used in the study.	Citric Acid	225-236	coagulation factor V	Homo sapiens	37-40
17143956-2	2006	METHODS: Rabbit-anti-FHIT antibody was used to detect FHIT protein expression in 64 formalin-fixed, paraffin-embedded tissue specimens of inflammatory bowel disease (IBD) by citrate-microwave-streptavidin (SP)-HRP immunohistochemical method.	Citric Acid	174-181	fragile histidine triad diadenosine triphosphatase	Homo sapiens	21-25
17143956-2	2006	METHODS: Rabbit-anti-FHIT antibody was used to detect FHIT protein expression in 64 formalin-fixed, paraffin-embedded tissue specimens of inflammatory bowel disease (IBD) by citrate-microwave-streptavidin (SP)-HRP immunohistochemical method.	Citric Acid	174-181	fragile histidine triad diadenosine triphosphatase	Homo sapiens	54-58
17102648-6	2006	The plasma levels of F1+2 and TAT, measured in a subset of 30 untreated patients, were significantly lower when blood was collected in polymer than in glass tubes, for both citrate concentrations.	Citric Acid	173-180	coagulation factor XII	Homo sapiens	21-25
17139575-4	2006	Glucokinase, a glucose phosphorylating enzyme, functions as a metabolic glucose sensor, which couples changes in physiological glucose concentration in the pancreatic beta cells and in the liver to the intermediary metabolism, i.e. glycolysis, the citrate cycle and respiratory-chain phosphorylation.	Citric Acid	248-255	glucokinase	Homo sapiens	0-11
16923776-10	2006	However, comparisons of preference ratios and consumption volumes indicated that both wild-type and TRPV1 knockout mice avoided citric acid in quite a similar manner, suggesting that TRPV1 receptors do not mediate the detection of citric acid.	Citric Acid	128-139	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	100-105
17131383-5	2006	The PI4K230 immunoreactivity of the nucleolus is masked in PFA fixed cells, but it can be restored by treatment of PFA fixed cells with hot wet citrate buffer or by washing the cryosections with PBS prior to PFA fixation.	Citric Acid	144-151	phosphatidylinositol 4-kinase alpha	Homo sapiens	4-11
16935279-3	2006	This histamine-induced increase in the number of citric acid-induced coughs was dose dependently and significantly reduced when animals were pretreated with fexofenadine, a histamine H1 receptor antagonist.	Citric Acid	49-60	histamine H1 receptor	Cavia porcellus	173-194
16868074-8	2006	Across all tissues, there was a profound decrease in glucose and a number of amino acids, including glutamine and alanine, and an increase in lactate, demonstrating that a failure to express PPAR-alpha results in perturbations in glycolysis, the citric acid cycle, and gluconeogenesis.	Citric Acid	246-257	peroxisome proliferator activated receptor alpha	Mus musculus	191-201
16705147-10	2006	We conclude that 1) oxidant-induced activation of ERK1/2 but not p38 or JNK reduces mitochondrial respiration and ATP production by decreasing complex I activity and substrate oxidation through complex I, 2) citric acid cycle dehydrogenases are not under control of the ERK1/2 pathway in oxidant-injured RPTC, 3) the protective effects of ERK1/2 inhibition are not due to activation of Akt, and 4) ERK1/2 and PKC-epsilon mediate oxidant-induced mitochondrial dysfunction through independent pathways.	Citric Acid	208-219	mitogen-activated protein kinase 3	Homo sapiens	50-56
16914432-1	2006	Experiments carried out in conscious guinea pigs suggest that citric acid-evoked coughing is partly mediated by transient receptor potential vanilloid type 1 (TRPV1) receptor-dependent activation of tachykinin-containing, capsaicin-sensitive C fibers.	Citric Acid	62-73	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	112-157
17015275-3	2006	Thermal treatment of pooled samples of human citrate-plasma or EDTA-plasma at 50 degrees C resulted in a rapid and parallel loss of fibrinogen concentration and AOPP reactivity.	Citric Acid	45-52	fibrinogen beta chain	Homo sapiens	132-142
16914432-1	2006	Experiments carried out in conscious guinea pigs suggest that citric acid-evoked coughing is partly mediated by transient receptor potential vanilloid type 1 (TRPV1) receptor-dependent activation of tachykinin-containing, capsaicin-sensitive C fibers.	Citric Acid	62-73	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	159-164
16627674-3	2006	Irritant agents, including capsaicin, resiniferatoxin, and citric acid, elicit cough in humans and in experimental animals through the activation of the transient receptor potential vanilloid 1 (TRPV1).	Citric Acid	59-70	transient receptor potential cation channel subfamily V member 1	Homo sapiens	153-193
16627674-3	2006	Irritant agents, including capsaicin, resiniferatoxin, and citric acid, elicit cough in humans and in experimental animals through the activation of the transient receptor potential vanilloid 1 (TRPV1).	Citric Acid	59-70	transient receptor potential cation channel subfamily V member 1	Homo sapiens	195-200
16458993-3	2006	The present study explores the effects of pyruvate, aspartate and citrate on improving the abnormalities observed in the Ctrn-/- liver.	Citric Acid	66-73	solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13	Mus musculus	121-125
16627674-7	2006	However, they potentiated citric acid- and resiniferatoxin-induced cough, an effect that was completely prevented by the TRPV1 receptor antagonist capsazepine.	Citric Acid	26-37	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	121-126
17044470-0	2006	Citrate attenuates tubulointerstitial fibrosis in 5/6 nephrectomized rats by decreasing transforming growth factor-beta1.	Citric Acid	0-7	transforming growth factor, beta 1	Rattus norvegicus	88-120
17044470-9	2006	CONCLUSION: As such, in 5/6 nephrectomized rats, citrate therapy for eight weeks could decrease tubulointerstitial fibrosis mainly by reducing the heightened renal TGF-beta1 levels and additionally by attenuating the increased myofibroblast activity.	Citric Acid	49-56	transforming growth factor, beta 1	Rattus norvegicus	164-173
16682415-1	2006	The tricarboxylate carrier (TCC), also known as citrate carrier, is an integral protein of the mitochondrial inner membrane.	Citric Acid	48-55	sideroflexin 3	Rattus norvegicus	4-26
16682415-1	2006	The tricarboxylate carrier (TCC), also known as citrate carrier, is an integral protein of the mitochondrial inner membrane.	Citric Acid	48-55	sideroflexin 3	Rattus norvegicus	28-31
16644293-2	2006	Alpha lactoalbumin concentrated in the polyethyleneglycol rich-phase, while beta-lactoglobulin, bovine serum albumin and alpha-1 antitrypsin showed affinity for the citrate rich-phase.	Citric Acid	165-172	albumin	Homo sapiens	103-116
16644293-2	2006	Alpha lactoalbumin concentrated in the polyethyleneglycol rich-phase, while beta-lactoglobulin, bovine serum albumin and alpha-1 antitrypsin showed affinity for the citrate rich-phase.	Citric Acid	165-172	serpin family A member 1	Homo sapiens	121-140
16722645-0	2006	Homology modeling of human serum carnosinase, a potential medicinal target, and MD simulations of its allosteric activation by citrate.	Citric Acid	127-134	carnosine dipeptidase 1	Homo sapiens	27-44
16722645-2	2006	The present study was undertaken with a view to model the serum carnosinase and its catalytic site and to unravel the molecular mechanism by which citrate ions increase the catalytic efficiency of serum carnosinase.	Citric Acid	147-154	carnosine dipeptidase 1	Homo sapiens	58-75
16722645-2	2006	The present study was undertaken with a view to model the serum carnosinase and its catalytic site and to unravel the molecular mechanism by which citrate ions increase the catalytic efficiency of serum carnosinase.	Citric Acid	147-154	carnosine dipeptidase 1	Homo sapiens	197-214
16425198-3	2006	Additionally, MRS performed on the prostate epithelia of probasin-ErbB-2Delta x Pten(+/-) mice identified changes in the relative concentrations of the metabolites choline and citrate, which was not observed in TRAMP mice.	Citric Acid	176-183	phosphatase and tensin homolog	Mus musculus	80-84
16425198-3	2006	Additionally, MRS performed on the prostate epithelia of probasin-ErbB-2Delta x Pten(+/-) mice identified changes in the relative concentrations of the metabolites choline and citrate, which was not observed in TRAMP mice.	Citric Acid	176-183	translocating chain-associating membrane protein 1	Mus musculus	211-216
16640561-8	2006	Kinetic analysis of PFK-1 showed low sensitivity towards its allosteric inhibitors citrate and ATP, at physiological concentrations of the activator Fru(2,6)P2.	Citric Acid	83-90	phosphofructokinase, liver type	Rattus norvegicus	20-25
16691347-1	2006	Solution combustion technique has been used to prepare hydroxypatite (HAp) powder from calcium nitrate, di-ammonium hydrogen phosphate and citric acid precursors.	Citric Acid	139-150	reticulon 3	Homo sapiens	70-73
16343525-1	2006	Citrate-capped gold nanoparticles (NPs) in aqueous solution were transferred directly into the organic solution mesitylene containing C-undecylcalix[4]-resorcinarene (C11-resorcinarene).	Citric Acid	0-7	RNA polymerase III subunit K	Homo sapiens	167-170
16517595-8	2006	We studied the regulation of hK5 activity by cations (Zn2+, Ca2+, Mg2+, Na2+, and K+) and citrate and showed that Zn can efficiently inhibit hK5 activity at levels well below its normal concentration in the prostate.	Citric Acid	90-97	keratin 5	Homo sapiens	29-32
16516867-3	2006	In the present study, we investigated the characteristics of Na+ -dependent citrate transport in primary cultures of neurons from mouse cerebral cortex and established the molecular identity of this transport system as the Na+ -coupled citrate transporter (NaC2/NaCT).	Citric Acid	76-83	nucleus accumbens associated 2, BEN and BTB (POZ) domain containing	Mus musculus	257-261
16720243-3	2006	186Re-MAMA-HBP was prepared by a reaction with 186ReO(4-) and SnCl2 in citrate buffer after the deprotection of the Tr groups of Tr-MAMA-HBP.	Citric Acid	71-78	heme binding protein 1	Homo sapiens	11-14
16516867-3	2006	In the present study, we investigated the characteristics of Na+ -dependent citrate transport in primary cultures of neurons from mouse cerebral cortex and established the molecular identity of this transport system as the Na+ -coupled citrate transporter (NaC2/NaCT).	Citric Acid	76-83	solute carrier family 13 (sodium-dependent citrate transporter), member 5	Mus musculus	262-266
16489927-3	2006	AsAT from the rat liver was specified by substrate inhibition and also by changes in the enzyme affinity for the substrates under the influence of some intermediates of the tricarboxylic acid cycle: isocitrate, succinate, fumarate, and citrate.	Citric Acid	202-209	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	0-4
16566597-1	2006	The Na+/dicarboxylate cotransporter 1 (NaDC1) is a low-affinity transporter for citric acid cycle intermediates such as succinate and citrate.	Citric Acid	80-91	solute carrier family 13 member 2	Oryctolagus cuniculus	4-37
16566597-1	2006	The Na+/dicarboxylate cotransporter 1 (NaDC1) is a low-affinity transporter for citric acid cycle intermediates such as succinate and citrate.	Citric Acid	80-91	solute carrier family 13 member 2	Oryctolagus cuniculus	39-44
16566597-1	2006	The Na+/dicarboxylate cotransporter 1 (NaDC1) is a low-affinity transporter for citric acid cycle intermediates such as succinate and citrate.	Citric Acid	134-141	solute carrier family 13 member 2	Oryctolagus cuniculus	4-37
16566597-1	2006	The Na+/dicarboxylate cotransporter 1 (NaDC1) is a low-affinity transporter for citric acid cycle intermediates such as succinate and citrate.	Citric Acid	134-141	solute carrier family 13 member 2	Oryctolagus cuniculus	39-44
16517173-5	2006	PRL supports the growth of pancreatic islets, stimulates insulin secretion and increases citrate production in the prostate.	Citric Acid	89-96	prolactin	Homo sapiens	0-3
16566829-13	2006	The regulation of EAAC1 expression and L-aspartate transport by testosterone and prolactin is consistent with their regulation of citrate production in prostate cells.	Citric Acid	130-137	solute carrier family 1 member 1	Homo sapiens	18-23
16094633-1	2006	Mitochondrial aconitase (mACON) contains a [4Fe-4S] cluster as the key enzyme for citrate oxidation in the human prostatic epithelial cell.	Citric Acid	82-89	aconitase 2	Homo sapiens	0-23
16211368-4	2006	The other members of the family (NaDC1, NaDC3, and NaCT) are transporters for di- and tri-carboxylates including succinate, citrate and alpha-ketoglutarate.	Citric Acid	124-131	solute carrier family 13 member 2	Homo sapiens	33-38
16211368-4	2006	The other members of the family (NaDC1, NaDC3, and NaCT) are transporters for di- and tri-carboxylates including succinate, citrate and alpha-ketoglutarate.	Citric Acid	124-131	solute carrier family 13 member 3	Homo sapiens	40-45
16211368-4	2006	The other members of the family (NaDC1, NaDC3, and NaCT) are transporters for di- and tri-carboxylates including succinate, citrate and alpha-ketoglutarate.	Citric Acid	124-131	solute carrier family 13 member 2	Homo sapiens	51-55
16391084-4	2006	The aatA mutation with an insertion of the neomycin resistance gene within the aatA coding region showed reduced resistance to acetic acid, formic acid, propionic acid, and lactic acid, whereas the aatA mutation exerted no effects on resistance to various drugs, growth at low pH (adjusted with HCl), assimilation of acetic acid, or resistance to citric acid.	Citric Acid	347-358	AatA, outermembrane protein	Escherichia coli	4-8
16286459-3	2006	ADAMTS13 activity in citrate-anticoagulated plasma was enhanced approximately 2-fold by zinc ions, approximately 3-fold by calcium ions, and approximately 6-fold by both ions, suggesting cooperative activation.	Citric Acid	21-28	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	0-8
16286459-5	2006	Barium ions stimulated ADAMTS13 activity in citrated plasma but not in citrate-free plasma.	Citric Acid	44-51	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	23-31
16286459-6	2006	Therefore, the stimulation by barium ions of ADAMTS13 in citrated plasma appears to reflect the release of chelated calcium and zinc ions from complexes with citrate.	Citric Acid	57-64	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	45-53
16300682-10	2005	CONCLUSION: We conclude that PEPCK-C is required not only for gluconeogenesis and glyceroneogenesis but also for cataplerosis (i.e. the removal of citric acid cycle anions) and that the failure of this process in the livers of PEPCK-C-/- mice results in a marked reduction in citric acid cycle flux and the shunting of hepatic lipid into triglyceride, resulting in a fatty liver.	Citric Acid	147-158	phosphoenolpyruvate carboxykinase 1, cytosolic	Mus musculus	29-36
16174656-4	2006	Compared with placebo, trimetazidine induced 1) an increase in insulin-induced forearm glucose uptake and glucose oxidation accompanied by a reduction in forearm lipid oxidation and citrate release and 2) a decrease of endothelin-1 release paralleled by a significant increase in forearm cGMP release.	Citric Acid	182-189	insulin	Homo sapiens	63-70
16269513-7	2006	Ex vivo copeptin stability (<20% loss of analyte) for at least 7 days at room temperature and 14 days at 4 degrees C was shown for serum and EDTA-, heparin-, and citrate plasma.	Citric Acid	165-172	arginine vasopressin	Homo sapiens	8-16
16798056-0	2006	Citrate enhances in vitro metastatic behaviours of PC-3M human prostate cancer cells: status of endogenous citrate and dependence on aconitase and fatty acid synthase.	Citric Acid	0-7	fatty acid synthase	Homo sapiens	147-166
17278781-4	2006	In the citric plasma obtained from venous blood concentration of plasmin-alpha2 antiplasmin complexes (PAP) using immunosorbed method (ELISA), alpha-2-antiplasmin with chromogenic method, concentration of fibrinogen and fibrin/ /fibrinogen degradation products (FDP) were determined.	Citric Acid	7-13	plasminogen	Homo sapiens	65-72
16444687-7	2006	Citric acid was found to give comparable results in terms of N recovery and 15N values, both for NH4+ and for NO3- samples.	Citric Acid	0-11	NBL1, DAN family BMP antagonist	Homo sapiens	110-113
16144965-7	2005	Excretion of ammonium, titratable acid, and citrate were the same in Slc26a4 null and wild-type mice.	Citric Acid	44-51	solute carrier family 26, member 4	Mus musculus	69-76
20050561-4	2006	Between 38 and 189 gREEs/hm2 per year (available for plants, estimated by 2% citric acid) will be introduced into the soil solution when applying 320 kg superphosphate/hm2 per year.	Citric Acid	77-88	cholinergic receptor muscarinic 2	Homo sapiens	25-28
16604823-5	2006	Immunostaining of 5 pm sections for maspin expression was obtained using the citrate antigen retrieval method.	Citric Acid	77-84	serpin family B member 5	Homo sapiens	36-42
16300682-10	2005	CONCLUSION: We conclude that PEPCK-C is required not only for gluconeogenesis and glyceroneogenesis but also for cataplerosis (i.e. the removal of citric acid cycle anions) and that the failure of this process in the livers of PEPCK-C-/- mice results in a marked reduction in citric acid cycle flux and the shunting of hepatic lipid into triglyceride, resulting in a fatty liver.	Citric Acid	276-287	phosphoenolpyruvate carboxykinase 1, cytosolic	Mus musculus	29-36
16370207-3	2005	The promotors (oxalate, calcium, uric acid, phosphates) and inhibitors (citrate, magnesium) are statistically significant between G1, G2 and G3, G2.	Citric Acid	72-79	proline rich protein BstNI subfamily 3	Homo sapiens	130-147
16226706-4	2005	A key enzyme linking glucose metabolism to lipid synthesis is ATP citrate lyase (ACL), which catalyzes the conversion of citrate to cytosolic acetyl-CoA.	Citric Acid	66-73	ATP citrate lyase	Homo sapiens	81-84
16164960-6	2005	Both dusts and a citrate extract caused phosphorylation of the EGF receptor on tyrosine 845, an indicator of Src activity.	Citric Acid	17-24	epidermal growth factor receptor	Rattus norvegicus	63-75
16164960-6	2005	Both dusts and a citrate extract caused phosphorylation of the EGF receptor on tyrosine 845, an indicator of Src activity.	Citric Acid	17-24	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	109-112
16027120-6	2005	We observed that inhibition of malate transport by Slc25a10 suppression significantly reduced the citrate transport from the mitochondria to the cytosol.	Citric Acid	98-105	solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10	Mus musculus	51-59
15961223-2	2005	For ferrihydrite, the organic species increased %As(V) extraction in the order: acetate<oxalate<<citrate.	Citric Acid	106-113	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	49-54
16027120-9	2005	These results suggested that Slc25a10 plays an important role in supplying malate for citrate transport required for fatty acid synthesis and indicated that inhibition of Slc25a10 might effectively reduce lipid accumulation in adipose tissues.	Citric Acid	86-93	solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10	Mus musculus	29-37
16027120-9	2005	These results suggested that Slc25a10 plays an important role in supplying malate for citrate transport required for fatty acid synthesis and indicated that inhibition of Slc25a10 might effectively reduce lipid accumulation in adipose tissues.	Citric Acid	86-93	solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10	Mus musculus	171-179
16007201-5	2005	The net conversion of glucose to lipid is dependent on the ability of cells to produce cytosolic acetyl CoA from mitochondria-derived citrate through the action of ATP citrate lyase (ACL).	Citric Acid	134-141	ATP citrate lyase	Homo sapiens	164-181
16007201-5	2005	The net conversion of glucose to lipid is dependent on the ability of cells to produce cytosolic acetyl CoA from mitochondria-derived citrate through the action of ATP citrate lyase (ACL).	Citric Acid	134-141	ATP citrate lyase	Homo sapiens	183-186
16135743-2	2005	PLCbeta2 KO mice displayed no concentration-dependent licking of the prototypical sweetener sucrose but were similar to wild-type mice in their responses to citric acid and NaCl, notwithstanding some interesting exceptions.	Citric Acid	157-168	phospholipase C, beta 2	Mus musculus	0-8
16087232-3	2005	Under non-stimulated conditions, the same transport processes can regulate matrix Ca2+ concentrations and hence citric acid cycle activity.	Citric Acid	112-123	carbonic anhydrase 2	Homo sapiens	82-85
16089431-1	2005	The binding of titanium(IV) to human serum transferrin in 50 mM Tris with 20 mM bicarbonate and 10 mM citrate at pH 7.4 was studied by UV/vis kinetics and by isothermal titration calorimetry.	Citric Acid	102-109	transferrin	Homo sapiens	43-54
15933230-0	2005	Simultaneous treatment with citrate prevents nephropathy induced by FYX-051, a xanthine oxidoreductase inhibitor, in rats.	Citric Acid	28-35	xanthine dehydrogenase	Rattus norvegicus	79-102
16089431-2	2005	Ti(IV) citrate, [Ti(C6H4O7)3]8-, employed in this study was previously characterized and delivers the metal to transferrin rapidly, allowing the quantification of the intrinsic binding constants for Ti(IV) to the C- and N-sites of transferrin.	Citric Acid	7-14	transferrin	Homo sapiens	111-122
16089431-2	2005	Ti(IV) citrate, [Ti(C6H4O7)3]8-, employed in this study was previously characterized and delivers the metal to transferrin rapidly, allowing the quantification of the intrinsic binding constants for Ti(IV) to the C- and N-sites of transferrin.	Citric Acid	7-14	transferrin	Homo sapiens	231-242
16097770-6	2005	The decrease in the detectability produced by the potential formation of SPC salts with divalent cations such as Ca2+ can be prevented by lowering the pH of the assay medium below the pKa value of the SPC carboxylic group and using a buffer chelating with properties such as citrate buffer.	Citric Acid	275-282	proline rich protein gene cluster	Homo sapiens	73-76
16097770-6	2005	The decrease in the detectability produced by the potential formation of SPC salts with divalent cations such as Ca2+ can be prevented by lowering the pH of the assay medium below the pKa value of the SPC carboxylic group and using a buffer chelating with properties such as citrate buffer.	Citric Acid	275-282	proline rich protein gene cluster	Homo sapiens	201-204
16026159-4	2005	This is in agreement with the strength of protein-anion interactions at the IL-1ra single anion-binding site as judged by the estimated dissociation constant values of 2.9 mM, 3.8 mM, and 13.7 mM for pyrophosphate, citrate, and phosphate, respectively.	Citric Acid	215-222	interleukin 1 receptor antagonist	Homo sapiens	76-82
16014041-0	2005	High citrate diet delays progression of renal insufficiency in the ClC-5 knockout mouse model of Dent"s disease.	Citric Acid	5-12	chloride channel, voltage-sensitive 5	Mus musculus	67-72
16014041-3	2005	METHODS: We studied the effect of zero and high citrate diet on renal function of ClC-5 knockout mice and wild-type mice.	Citric Acid	48-55	chloride channel, voltage-sensitive 5	Mus musculus	82-87
16014041-6	2005	RESULTS: ClC-5 knockout mice fed zero or high citrate diet had significantly increased urinary calcium excretion compared with wild-type mice fed the same diets.	Citric Acid	46-53	chloride channel, voltage-sensitive 5	Mus musculus	9-14
16014041-8	2005	ClC-5 knockout mice fed a zero citrate diet had significantly increased tubular atrophy, interstitial fibrosis, cystic changes, and nephrocalcinosis compared to ClC-5 knockout mice fed a high citrate diet.	Citric Acid	31-38	chloride channel, voltage-sensitive 5	Mus musculus	0-5
16014041-8	2005	ClC-5 knockout mice fed a zero citrate diet had significantly increased tubular atrophy, interstitial fibrosis, cystic changes, and nephrocalcinosis compared to ClC-5 knockout mice fed a high citrate diet.	Citric Acid	192-199	chloride channel, voltage-sensitive 5	Mus musculus	0-5
16014041-9	2005	Transforming growth factor-beta1 (TGF-beta1) was significantly increased in 9-month-old ClC-5 knockout mice on zero citrate diet compared to 9-month-old wild-type mice on the same diet.	Citric Acid	116-123	transforming growth factor, beta 1	Mus musculus	0-32
16014041-9	2005	Transforming growth factor-beta1 (TGF-beta1) was significantly increased in 9-month-old ClC-5 knockout mice on zero citrate diet compared to 9-month-old wild-type mice on the same diet.	Citric Acid	116-123	transforming growth factor, beta 1	Mus musculus	34-43
16014041-9	2005	Transforming growth factor-beta1 (TGF-beta1) was significantly increased in 9-month-old ClC-5 knockout mice on zero citrate diet compared to 9-month-old wild-type mice on the same diet.	Citric Acid	116-123	chloride channel, voltage-sensitive 5	Mus musculus	88-93
16014041-10	2005	CONCLUSION: High citrate diet preserved renal function and delayed progression of renal disease in ClC-5 knockout mice even in the apparent absence of stone formation.	Citric Acid	17-24	chloride channel, voltage-sensitive 5	Mus musculus	99-104
15981006-7	2005	The addition of citrate to urine also produced a rise in the pHn.	Citric Acid	16-23	carbamoyl-phosphate synthase 1	Homo sapiens	61-64
15882280-5	2005	After adjustment for illness severity, antithrombin-III levels increased significantly more over the period of study in the citrate as compared to the heparin group (P= 0.038).	Citric Acid	124-131	serpin family C member 1	Homo sapiens	39-55
15883004-2	2005	The crystal structures of human dPGM-B bound with citrate were determined in two crystal forms.	Citric Acid	50-57	Phosphoglucose mutase 1	Drosophila melanogaster	32-36
15883004-5	2005	The citrate-binding mode suggests a substrate-binding model, consistent with the structure of Escherichia coli dPGM/vanadate complex.	Citric Acid	4-11	Phosphoglucose mutase 1	Drosophila melanogaster	111-115
16201454-1	2005	Mitochondrial aconitase (mACON) is the key enzyme for the citrate oxidation in the mitochondrial Krebs cycle.	Citric Acid	58-65	aconitase 2	Homo sapiens	0-23
15882280-6	2005	Moreover, after adjustment for antithrombin-III levels and illness severity score, the relative risk of hemorrhage with citrate anticoagulation was significantly lower than that with heparin (relative risk of 0.14; 95% CI 0.02 to 0.96, P= 0.05).	Citric Acid	120-127	serpin family C member 1	Homo sapiens	31-47
15636585-6	2005	It appears that the first step in the aconitase reaction (conversion of citrate into the intermediate cis-aconitate) is more severely affected, as recombinant IRP1(S711E) retains approx.	Citric Acid	72-79	aconitase 1	Homo sapiens	159-163
15929998-6	2005	These structural changes, which altogether cause a reduction of the substrate-binding cavity volume (from 776 A(3) in the presence of testosterone/acetate to 704 A(3) in the acetate/citrate complex), are reminiscent of the "induced-fit" mechanism previously proposed for the aldose reductase, another member of the AKR superfamily.	Citric Acid	182-189	aldo-keto reductase family 1 member B	Homo sapiens	275-291
15636585-8	2005	When expressed in mammalian cells, IRP1(S711E) completely fails to bind to RNA and to generate isocitrate from citrate.	Citric Acid	98-105	aconitase 1	Homo sapiens	35-39
16511074-4	2005	Whereas IRP2 is known to be involved in Fe homeostasis, the role of IRP1 is less clear; it may provide a link between citrate and iron metabolisms and be involved in oxidative stress response.	Citric Acid	118-125	aconitase 1	Homo sapiens	68-72
15817147-4	2005	Optimal MAP-2 immunoreactivity was observed only when MAP-2 antibody clone AP18 was used in conjunction with citric acid buffer of pH 6.0.	Citric Acid	109-120	microtubule-associated protein 2	Cavia porcellus	8-13
15834009-4	2005	In this study, we investigated the regulatory role of plasma membrane H+-ATPase on the Al-induced secretion of citrate from soybean roots.	Citric Acid	111-118	plasma membrane ATPase 4	Glycine max	70-79
15834009-6	2005	Vanadate and fusicoccin, an inhibitor and an activator, respectively, of plasma membrane H+-ATPase, exerted inhibitory and stimulatory effects on the Al-induced secretion of citrate.	Citric Acid	174-181	plasma membrane ATPase 4	Glycine max	89-98
15834009-7	2005	Higher activity of plasma membrane H+-ATPase coincided with more citrate secretion in Al-resistant than Al-sensitive soybean cultivars.	Citric Acid	65-72	plasma membrane ATPase 4	Glycine max	35-44
15834009-8	2005	These results suggested that the effects of Al stress on citrate secretion were mediated via modulation of the activity of plasma membrane H+-ATPase.	Citric Acid	57-64	plasma membrane ATPase 4	Glycine max	139-148
15834009-9	2005	The relationship between the Al-induced secretion of citrate and the activity of plasma membrane H+-ATPase was further demonstrated by analysis of plasma membrane H+-ATPase transgenic Arabidopsis (Arabidopsis thaliana).	Citric Acid	53-60	plasma membrane ATPase 4	Glycine max	97-106
15834009-9	2005	The relationship between the Al-induced secretion of citrate and the activity of plasma membrane H+-ATPase was further demonstrated by analysis of plasma membrane H+-ATPase transgenic Arabidopsis (Arabidopsis thaliana).	Citric Acid	53-60	plasma membrane ATPase 4	Glycine max	163-172
15834009-14	2005	Taken together, our results demonstrated that up-regulation of plasma membrane H+-ATPase activity was associated with the secretion of citrate from soybean roots.	Citric Acid	135-142	plasma membrane ATPase 4	Glycine max	79-88
15781190-5	2005	Considering that pyruvate carboxylase is a key enzyme for anaplerosis, besides the new perspectives brought by anaplerotic therapies in those rare pyruvate carboxylase deficiencies, this therapeutic trial also emphasizes the possible extended indications of triheptanoin in various diseases where the citric acid cycle is impaired.	Citric Acid	301-312	pyruvate carboxylase	Homo sapiens	17-37
15914972-13	2005	Co-administration of citrate or L-Arg improved the CsA- and L-NAME-induced acidosis and hyperkalemia.	Citric Acid	21-28	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	51-54
15914972-19	2005	Citrate, at least in part, directly reduces the protonation of bone in animals treated with CsA and is recommended as a potential adjunct drug to prevent bone demineralization in patients chronically receiving CsA.	Citric Acid	0-7	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	92-95
15914972-19	2005	Citrate, at least in part, directly reduces the protonation of bone in animals treated with CsA and is recommended as a potential adjunct drug to prevent bone demineralization in patients chronically receiving CsA.	Citric Acid	0-7	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	210-213
15882437-5	2005	The levels of TIMP-2 were measured in ethylenediaminetetraacetic acid (EDTA) and citrate plasma from healthy donors.	Citric Acid	81-88	TIMP metallopeptidase inhibitor 2	Homo sapiens	14-20
15882437-7	2005	The TIMP-2 concentration in citrate plasma from 15 patients with advanced, stage IV breast cancer had a median value of 160 ng/ml, only slightly higher but statistically distinguishable from the level found in citrate plasma from the healthy donors.	Citric Acid	28-35	TIMP metallopeptidase inhibitor 2	Homo sapiens	4-10
15882437-7	2005	The TIMP-2 concentration in citrate plasma from 15 patients with advanced, stage IV breast cancer had a median value of 160 ng/ml, only slightly higher but statistically distinguishable from the level found in citrate plasma from the healthy donors.	Citric Acid	210-217	TIMP metallopeptidase inhibitor 2	Homo sapiens	4-10
15557328-4	2005	Apart from its ability to convert citrate to iso-citrate, IRP1 in its apo-form binds to iron-responsive elements in the untranslated regions of mRNAs coding for proteins involved in iron metabolism, to regulate their synthesis and thus control the cellular homeostasis of this metal.	Citric Acid	34-41	aconitase 1	Mus musculus	58-62
15725511-3	2005	Rats from control and citrate groups had free access to tap water and to a sodium citrate solution (35 mM), respectively.	Citric Acid	22-29	nuclear RNA export factor 1	Rattus norvegicus	56-59
15728336-12	2005	In conclusion, these results show that Arabidopsis vacuoles contain at least two transporters and a channel for dicarboxylates and citrate and that the activity of AttDT is critical for regulation of pH homeostasis.	Citric Acid	131-138	tonoplast dicarboxylate transporter	Arabidopsis thaliana	164-169
15643195-6	2005	Semen from a 47-year-old man with benign prostatic hyperplasia and a PSA of 5.5 ng/ml contained 156 mM citrate.	Citric Acid	103-110	kallikrein related peptidase 3	Homo sapiens	69-72
15664815-3	2005	The cytosolic isozyme hCA I was strongly activated by acetate, oxalate, pyruvate, l-lactate, and citrate (K(A) around 0.1 microM), whereas formate, malonate, malate, and benzoate were weaker activators (K(A) in the range 0.1-1mM).	Citric Acid	97-104	carbonic anhydrase 1	Homo sapiens	22-27
15664815-5	2005	The membrane-associated isozyme hCA IV was the most sensitive to inhibition by carboxylates, showing a K(I) of 99 nM for citrate and oxalate, of 2.8 microM for malonate and of 14.5 microM for pyruvate among others.	Citric Acid	121-128	carbonic anhydrase 4	Homo sapiens	32-38
15733107-0	2005	Effects of potassium-magnesium citrate supplementation on cytosolic ATP citrate lyase and mitochondrial aconitase activity in leukocytes: a window on renal citrate metabolism.	Citric Acid	31-38	ATP citrate lyase	Homo sapiens	68-85
15733107-0	2005	Effects of potassium-magnesium citrate supplementation on cytosolic ATP citrate lyase and mitochondrial aconitase activity in leukocytes: a window on renal citrate metabolism.	Citric Acid	31-38	aconitase 2	Homo sapiens	90-113
15733107-1	2005	BACKGROUND: An increase in urinary citrate excretion is associated with a decrease in activity of renal cortical cytosolic ATP citrate lyase (ACL) and mitochondrial aconitase (m-aconitase).	Citric Acid	35-42	ATP citrate lyase	Homo sapiens	123-140
15733107-1	2005	BACKGROUND: An increase in urinary citrate excretion is associated with a decrease in activity of renal cortical cytosolic ATP citrate lyase (ACL) and mitochondrial aconitase (m-aconitase).	Citric Acid	35-42	ATP citrate lyase	Homo sapiens	142-145
15733107-1	2005	BACKGROUND: An increase in urinary citrate excretion is associated with a decrease in activity of renal cortical cytosolic ATP citrate lyase (ACL) and mitochondrial aconitase (m-aconitase).	Citric Acid	35-42	aconitase 2	Homo sapiens	151-174
15733107-1	2005	BACKGROUND: An increase in urinary citrate excretion is associated with a decrease in activity of renal cortical cytosolic ATP citrate lyase (ACL) and mitochondrial aconitase (m-aconitase).	Citric Acid	35-42	aconitase 2	Homo sapiens	176-187
15733107-9	2005	The decrease in ACL activity was inversely correlated with an increase in urinary excretion of both potassium (r = -0.620, P < 0.0001) and citrate (r = -0.451, P < 0.004).	Citric Acid	142-149	ATP citrate lyase	Homo sapiens	16-19
15733107-10	2005	A similar inverse correlation was observed between m-aconitase activity and urinary excretion of citrate (r = -0.322, P < 0.043).	Citric Acid	97-104	aconitase 2	Homo sapiens	51-62
15714566-2	2005	The stationary phase was 3-(1,8-naphthalimido) propyl-modified silyl silica gel (NAIP) and the best separations were achieved with 4.0 mM citrate buffer (pH 5.0) containing 80% methanol at an applied voltage of 25 kV.	Citric Acid	138-145	NLR family, apoptosis inhibitory protein 6	Rattus norvegicus	81-85
15585595-2	2005	In glucose-induced insulin secretion, the rate of pyruvate carboxylation is very high and correlates more strongly with the glucose concentration the beta-cell is exposed to (and thus with insulin release) than does pyruvate decarboxylation, which produces acetyl-CoA for metabolism in the citric acid cycle to produce ATP.	Citric Acid	290-301	insulin	Homo sapiens	19-26
15607730-3	2005	Expression of hNaS2 protein in Xenopus oocytes led to a Na(+)-dependent transport of sulfate that was inhibited by thiosulfate, phosphate, molybdate, selenate and tungstate, but not by oxalate, citrate, succinate, phenol red or DIDS.	Citric Acid	194-201	solute carrier family 13 member 4	Homo sapiens	14-19
15625112-6	2005	The influence of citrate and certain urinary proteins on adhesion was examined, and it was curious that osteopontin, a suspected regulator of stone formation, increased the adhesion force between a carboxylate tip and the (100) crystal face.	Citric Acid	17-24	secreted phosphoprotein 1	Homo sapiens	104-115
15607568-4	2005	GLA, through a molecular mechanism involving the lipogenic enzyme fatty acid synthase (FAS), coordinately interrupts the pathways that replenish the pools of metabolic intermediates in the citric acid cycle (cellular anaplerosis).	Citric Acid	189-200	fatty acid synthase	Homo sapiens	66-85
15842073-3	2005	In the present study, the activities of citric acid cycle enzymes, such as isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, succinate dehydrogenase, and malate dehydrogenase, were found to be decreased in aged rats as well as that of electron-transferring enzymes such as NADH dehydrogenase and cytochrome c oxidase.	Citric Acid	40-51	oxoglutarate dehydrogenase	Rattus norvegicus	101-134
15569629-4	2005	The method was used to determine the apparent dissociation constant, Kapp (+/- SD) of Mg2+ binding to aspartate (22 degrees C, 101.7 +/- 22.5 mmol/l, n = 8; 44 degrees C, 45.2 +/- 8.3 mmol/l, n = 6), citrate (high affinity, 0.33 +/- 0.14 mmol/l, n = 4; low affinity, approximately 80 mmol/l), malate (15.9 +/- 1.0 mmol/l, n = 7) and Ca2+ binding to malate (10.3 +/- 1.1 mmol/l, n = 7).	Citric Acid	200-207	mucin 7, secreted	Homo sapiens	86-89
15607568-4	2005	GLA, through a molecular mechanism involving the lipogenic enzyme fatty acid synthase (FAS), coordinately interrupts the pathways that replenish the pools of metabolic intermediates in the citric acid cycle (cellular anaplerosis).	Citric Acid	189-200	fatty acid synthase	Homo sapiens	87-90
15935834-7	2005	vWF values were comparable in citrate and acidified citrate plasma but serum and EDTA plasma samples yielded lower than expected results.	Citric Acid	30-37	von Willebrand factor	Homo sapiens	0-3
15771240-6	2005	The chelating agents citrate and EDTA have different effects on the rates of oxidation of methionine residues in G-CSF.	Citric Acid	21-28	colony stimulating factor 3	Homo sapiens	113-118
15456782-9	2004	In addition, 13C-labeling experiments revealed an increase in the conversion of pyruvate to citrate as a result of increased UCP protein content.	Citric Acid	92-99	Mitochondrial uncoupling protein 1-like	Solanum tuberosum	125-128
15322810-2	2004	Several conditions shown to induce AOX1 mRNA accumulation also result in an increase in cellular citrate concentrations, suggesting that citrate and/or other tricarboxylic acid (TCA) cycle intermediates may be important signal metabolites.	Citric Acid	97-104	ubiquinol oxidase 1, mitochondrial	Nicotiana tabacum	35-39
15596698-9	2004	CONCLUSION: (99m)Tc IL-8 offers many advantages over the conventionally used radiopharmaceuticals to image pulmonary infection, (67)Ga citrate and radiolabeled leukocytes, ie, rapid and easy preparation, short time span between injection and imaging, low radiation burden and, most importantly, clear delineation of the infectious foci.	Citric Acid	135-142	interleukin-8	Oryctolagus cuniculus	20-24
15322810-4	2004	We found that the exogenously supplied TCA cycle organic acids citrate, malate and 2-oxoglutarate caused rapid and dramatic increases in the steady-state level of AOX1 mRNA at low, near physiological concentrations (0.1 mM).	Citric Acid	63-70	ubiquinol oxidase 1, mitochondrial	Nicotiana tabacum	163-167
15545369-1	2004	A novel method for the separation of milk-fat globule membrane (MFGM) isolate by microfiltration in the presence of citrate was applied to prepare a fraction to be used to stabilize oil-in-water emulsions.	Citric Acid	116-123	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	37-62
15545369-1	2004	A novel method for the separation of milk-fat globule membrane (MFGM) isolate by microfiltration in the presence of citrate was applied to prepare a fraction to be used to stabilize oil-in-water emulsions.	Citric Acid	116-123	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	64-68
15322810-2	2004	Several conditions shown to induce AOX1 mRNA accumulation also result in an increase in cellular citrate concentrations, suggesting that citrate and/or other tricarboxylic acid (TCA) cycle intermediates may be important signal metabolites.	Citric Acid	137-144	ubiquinol oxidase 1, mitochondrial	Nicotiana tabacum	35-39
18404402-8	2004	Nature 2004; 429: 188-93) reported that GPR80 is a Gq-coupled receptor activated by the citric acid cycle intermediate, alpha-ketoglutarate.	Citric Acid	88-99	oxoglutarate receptor 1	Homo sapiens	40-45
15385375-0	2004	Parathyroid hormone secretion during citrate anticoagulated hemodialysis in acutely ill maintenance hemodialysis patients.	Citric Acid	37-44	parathyroid hormone	Homo sapiens	0-19
15502082-8	2004	Renin concentrations as measured by ICMA were identical in serum and EDTA-, heparin-, and citrate-anticoagulated plasmas.	Citric Acid	90-97	renin	Homo sapiens	0-5
15564525-9	2004	When examined in planta in response to citrate feeding, a strong conversion of AOX from its oxidized to its reduced form was observed in the transgenic line.	Citric Acid	39-46	ubiquinol oxidase 1, mitochondrial	Nicotiana tabacum	79-82
15543948-1	2004	The mitochondrial aconitase (mACON) containing a [4Fe-4S] cluster is regarded as the key enzyme for citrate oxidation in the epithelial cells of human prostate.	Citric Acid	100-107	aconitase 2	Homo sapiens	4-27
15327586-1	2004	BACKGROUND: The previous formulation of epoetin alfa in Japan was a citrate-buffered protein solution containing gelatin hydrolysate as the protein protective agent.	Citric Acid	68-75	erythropoietin	Homo sapiens	40-47
15327944-5	2004	Cytosolic aconitase (aco-1), iron regulatory protein, is known to regulate cellular iron concentration by modulating translation of the ferritin mRNA in addition to its enzymatic activity that converts citrate into iso-citrate.	Citric Acid	202-209	Cytoplasmic aconitate hydratase	Caenorhabditis elegans	21-26
15247478-4	2004	Frataxin interacted with aconitase in a citrate-dependent fashion, reduced the level of oxidant-induced inactivation, and converted inactive [3Fe-4S]1+ enzyme to the active [4Fe-4S]2+ form of the protein.	Citric Acid	40-47	frataxin	Homo sapiens	0-8
15296731-7	2004	The NTP binding pocket of UAP56 is occupied by a citrate ion, mimicking the phosphates of NTP and retaining the P loop in an open conformation.	Citric Acid	49-56	DExD-box helicase 39B	Homo sapiens	26-31
15240674-6	2004	Exposure to DETA-NO and NCX-4016 enhances glucose uptake, glycolytic rate, and lactate generation in CD3/CD28-costimulated lymphocytes, while reduced citric acid cycle intermediates.	Citric Acid	150-161	T cell leukemia homeobox 2	Homo sapiens	24-27
15196919-6	2004	Principal components analysis and Partial Least Squares-Discriminate analysis of the urine (1)H NMR spectra revealed significant differences between each of the cytokine adenovirus groups and the control groups; for the TNF-alpha group the main differences lay in citrate and succinate, while for the IL-1beta group the predominant changes occurred in leucine, isoleucine, valine and myo-inositol.	Citric Acid	264-271	tumor necrosis factor	Rattus norvegicus	220-229
15225178-8	2004	CONCLUSIONS: Proton pump inhibitor-induced false negative results on high-dose citric acid based urea breath test vary with the type of proton pump inhibitor used.	Citric Acid	79-90	ATPase H+/K+ transporting subunit alpha	Homo sapiens	13-24
15225178-8	2004	CONCLUSIONS: Proton pump inhibitor-induced false negative results on high-dose citric acid based urea breath test vary with the type of proton pump inhibitor used.	Citric Acid	79-90	ATPase H+/K+ transporting subunit alpha	Homo sapiens	136-147
14973148-2	2004	Citrate reabsorption is mediated by the Na-dicarboxylate cotransporter-1 (NaDC-1).	Citric Acid	0-7	solute carrier family 13 member 2L homeolog	Xenopus laevis	74-80
14973148-5	2004	When injected into Xenopus oocytes, the cotransporter is expressed and demonstrates Na-coupled citrate transport with a stoichiometry of >or=3 Na:1 citrate, specificity for di- and tricarboxylates, pH-dependent citrate transport, and pH-independent succinate transport, all characteristics of the other NaDC-1 orthologs.	Citric Acid	95-102	solute carrier family 13 member 2L homeolog	Xenopus laevis	306-312
14973148-5	2004	When injected into Xenopus oocytes, the cotransporter is expressed and demonstrates Na-coupled citrate transport with a stoichiometry of >or=3 Na:1 citrate, specificity for di- and tricarboxylates, pH-dependent citrate transport, and pH-independent succinate transport, all characteristics of the other NaDC-1 orthologs.	Citric Acid	151-158	solute carrier family 13 member 2L homeolog	Xenopus laevis	306-312
14973148-5	2004	When injected into Xenopus oocytes, the cotransporter is expressed and demonstrates Na-coupled citrate transport with a stoichiometry of >or=3 Na:1 citrate, specificity for di- and tricarboxylates, pH-dependent citrate transport, and pH-independent succinate transport, all characteristics of the other NaDC-1 orthologs.	Citric Acid	151-158	solute carrier family 13 member 2L homeolog	Xenopus laevis	306-312
15060089-1	2004	The tricarboxylate (citrate) carrier (TCC), a protein of the mitochondrial inner membrane, is an obligatory component of the shuttle system by which mitochondrial acetyl-CoA is transported into the cytosol, where lipogenesis occurs.	Citric Acid	20-27	sideroflexin 3	Rattus norvegicus	38-41
15138618-5	2004	Thus, IL-15 seems to be able to modulate de novo fatty acid synthesis, possibly by influencing citrate tissue levels, an allosteric activator of the key lipogenic enzyme acetyl-CoA carboxylase.	Citric Acid	95-102	interleukin 15	Rattus norvegicus	6-11
15141213-7	2004	4), a close relative of GPR91, responds to alpha-ketoglutarate, another intermediate in the citric acid cycle.	Citric Acid	92-103	succinate receptor 1	Homo sapiens	24-29
15147181-1	2004	The Saccharomyces cerevisiae Tmt1 gene product is the yeast homologue of the Escherichia coli enzyme that catalyzes the methyl esterification of trans-aconitate, a thermodynamically favored isomer of cis-aconitate and an inhibitor of the citric acid cycle.	Citric Acid	238-249	trans-aconitate 3-methyltransferase	Saccharomyces cerevisiae S288C	29-33
15147181-10	2004	These results suggest that the Tmt1 methyltransferase may work in two different pathways in two different ways: for detoxification in the citric acid cycle and for a possibly novel biosynthetic branch reaction of the leucine biosynthetic pathway.	Citric Acid	138-149	trans-aconitate 3-methyltransferase	Saccharomyces cerevisiae S288C	31-35
15110995-4	2004	We recently demonstrated that oxalomalate (OMA, alpha-hydroxy-beta-oxalosuccinic acid), a competitive inhibitor of aconitase, which is an enzyme of the citric acid cycle, remarkably decreases the binding activity of IRP1.	Citric Acid	152-163	aconitase 1	Homo sapiens	216-220
15149735-1	2004	Mitochondrial aconitase (mACON) is regarded as the key enzyme for citrate oxidation in human prostatic epithelial cells.	Citric Acid	66-73	aconitase 2	Homo sapiens	0-23
14678010-3	2004	When heterologously expressed in a mammalian cell line or in Xenopus oocytes, the cloned ceNAC-2 mediates the Na+-coupled transport of various intermediates of the citric acid cycle.	Citric Acid	164-175	Sodium-dependent high-affinity dicarboxylate transporter 2	Caenorhabditis elegans	89-96
14960588-1	2004	Acetyl-CoA synthetase 2 (AceCS2) produces acetyl-CoA for oxidation through the citric acid cycle in the mitochondrial matrix.	Citric Acid	79-90	acyl-CoA synthetase short-chain family member 1	Mus musculus	25-31
15255069-10	2004	A significant decrease in net acid excretion was observed upon citrate supplementation, and this was paralleled by a significant decrease of urinary deoxypyridinolines, hydroxyproline-to-creatinine ratios, and, to a lesser extent, serum osteocalcin.	Citric Acid	63-70	bone gamma-carboxyglutamate protein	Homo sapiens	237-248
15163023-7	2004	COX-2 immunohistochemistry was performed using affinity purified polyclonal murine antibody and avidin-biotin detection method with citrate antigen retrieval.	Citric Acid	132-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15039637-5	2004	The second involves uptake by low molecular weight organic anions such as ascorbate and citrate (non-transferrin bound uptake).	Citric Acid	88-95	transferrin	Homo sapiens	101-112
15060153-2	2004	Deletion of HOG1, SSK1, PBS2, PTC2, PTP2, and PTP3 resulted in sensitivity to citric acid.	Citric Acid	78-89	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	12-16
15060153-2	2004	Deletion of HOG1, SSK1, PBS2, PTC2, PTP2, and PTP3 resulted in sensitivity to citric acid.	Citric Acid	78-89	mitogen-activated protein kinase kinase kinase SSK1	Saccharomyces cerevisiae S288C	18-22
15060153-2	2004	Deletion of HOG1, SSK1, PBS2, PTC2, PTP2, and PTP3 resulted in sensitivity to citric acid.	Citric Acid	78-89	mitogen-activated protein kinase kinase PBS2	Saccharomyces cerevisiae S288C	24-28
15060153-2	2004	Deletion of HOG1, SSK1, PBS2, PTC2, PTP2, and PTP3 resulted in sensitivity to citric acid.	Citric Acid	78-89	type 2C protein phosphatase PTC2	Saccharomyces cerevisiae S288C	30-34
15060153-2	2004	Deletion of HOG1, SSK1, PBS2, PTC2, PTP2, and PTP3 resulted in sensitivity to citric acid.	Citric Acid	78-89	tyrosine protein phosphatase PTP2	Saccharomyces cerevisiae S288C	36-40
15060153-2	2004	Deletion of HOG1, SSK1, PBS2, PTC2, PTP2, and PTP3 resulted in sensitivity to citric acid.	Citric Acid	78-89	tyrosine protein phosphatase PTP3	Saccharomyces cerevisiae S288C	46-50
15060153-3	2004	Furthermore, citric acid resulted in the dual phosphorylation, and thus activation, of Hog1p.	Citric Acid	13-24	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	87-92
15060153-5	2004	HOG1 negatively regulated the expression of a number of proteins in response to citric acid stress, including Bmh1p.	Citric Acid	80-91	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	0-4
15060153-5	2004	HOG1 negatively regulated the expression of a number of proteins in response to citric acid stress, including Bmh1p.	Citric Acid	80-91	14-3-3 family protein BMH1	Saccharomyces cerevisiae S288C	110-115
15060153-6	2004	Evidence suggests that BMH1 is induced by citric acid to counteract the effect of amino acid starvation.	Citric Acid	42-53	14-3-3 family protein BMH1	Saccharomyces cerevisiae S288C	23-27
15060153-7	2004	In addition, deletion of BMH2 rendered cells sensitive to citric acid.	Citric Acid	58-69	14-3-3 family protein BMH2	Saccharomyces cerevisiae S288C	25-29
15060153-9	2004	HOG1 was also required for citric acid-induced up-regulation of Ssa1p and Eno2p.	Citric Acid	27-38	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	0-4
15060153-9	2004	HOG1 was also required for citric acid-induced up-regulation of Ssa1p and Eno2p.	Citric Acid	27-38	Hsp70 family ATPase SSA1	Saccharomyces cerevisiae S288C	64-69
15060153-9	2004	HOG1 was also required for citric acid-induced up-regulation of Ssa1p and Eno2p.	Citric Acid	27-38	phosphopyruvate hydratase ENO2	Saccharomyces cerevisiae S288C	74-79
15060153-10	2004	To counteract the cation chelating activity of citric acid, the plasma membrane Ca(2+) channel, CCH1, and a functional vacuolar membrane H(+)-ATPase were found to be essential for optimal adaptation.	Citric Acid	47-58	Cch1p	Saccharomyces cerevisiae S288C	96-100
15060153-11	2004	Also, the transcriptional regulator CYC8, which mediates glucose derepression, was required for adaptation to citric acid to allow cells to metabolize excess citrate via the tricarboxylic acid (TCA) cycle.	Citric Acid	110-121	transcription regulator CYC8	Saccharomyces cerevisiae S288C	36-40
15060153-11	2004	Also, the transcriptional regulator CYC8, which mediates glucose derepression, was required for adaptation to citric acid to allow cells to metabolize excess citrate via the tricarboxylic acid (TCA) cycle.	Citric Acid	158-165	transcription regulator CYC8	Saccharomyces cerevisiae S288C	36-40
15060153-12	2004	Supporting this, Mdh1p and Idh1p, both TCA cycle enzymes, were up-regulated in response to citric acid.	Citric Acid	91-102	malate dehydrogenase MDH1	Saccharomyces cerevisiae S288C	17-22
15060153-12	2004	Supporting this, Mdh1p and Idh1p, both TCA cycle enzymes, were up-regulated in response to citric acid.	Citric Acid	91-102	isocitrate dehydrogenase (NAD(+)) IDH1	Saccharomyces cerevisiae S288C	27-32
14656221-10	2004	Extracellular pH has a differential effect on the transport function of mouse NaCT depending on whether the transported substrate is citrate or succinate.	Citric Acid	133-140	solute carrier family 13 (sodium-dependent citrate transporter), member 5	Mus musculus	78-82
14644932-1	2004	This study was designed to determine whether extended ETS exposure enhances citric acid-induced cough and bronchoconstriction in young guinea pigs via a neurokinin-1 (NK-1) receptor mechanism at the first central synapse of lung afferent neurons, the nucleus tractus solitarius.	Citric Acid	76-87	substance-P receptor	Cavia porcellus	167-181
14972331-1	2004	A bioenergetic theory of prostate malignancy proposed that normal citrate-producing prostate epithelial cell become citrate-oxidizing cells, in which mitochondrial aconitase (mACON) is not limiting, providing the energy required for the onset and progression of malignancy and metastasis.	Citric Acid	116-123	aconitase 2	Homo sapiens	150-173
15129972-3	2004	Although the hypoglycemic effect was greatly improved when a dry insulin powder containing citric acid (MIC SD) was administered, insulin in the MIC SD was unstable compared with the other powders examined.	Citric Acid	91-102	insulin	Homo sapiens	65-72
15129972-6	2004	We modified the insulin dosage form with citric acid to improve the insulin stability at room temperature without loss of hypoglycemic activity.	Citric Acid	41-52	insulin	Homo sapiens	16-23
15129972-6	2004	We modified the insulin dosage form with citric acid to improve the insulin stability at room temperature without loss of hypoglycemic activity.	Citric Acid	41-52	insulin	Homo sapiens	68-75
15129972-7	2004	MIC Mix was formulated as a combination of insulin powder (MI") and citric acid powder (MC).	Citric Acid	68-79	Mix paired-like homeobox	Homo sapiens	4-7
14644932-5	2004	ETS exposure significantly enhanced citric acid-induced cough by 56% and maximal Penh (a measure of airway obstruction) by 43%, effects that were attenuated by the NK-1 receptor antagonist in the nucleus tractus solitarius.	Citric Acid	36-47	substance-P receptor	Cavia porcellus	164-177
14644932-6	2004	We conclude that in young guinea pigs extended exposure to ETS increases citric acid-induced cough and bronchoconstriction in part by an NK-1 receptor mechanism in the nucleus tractus solitarius.	Citric Acid	73-84	substance-P receptor	Cavia porcellus	137-150
12974670-3	2004	Both residues in PFK-C and Leu-767 in PFK-M were also observed to be critical for inhibition by citrate, which is synergistic with that by MgATP.	Citric Acid	96-103	phosphofructokinase, muscle	Homo sapiens	38-43
14706641-6	2004	The action of the kinases and NHERF-2 may link urinary citrate excretion to proximal tubular H(+) secretion.	Citric Acid	55-62	SLC9A3 regulator 2 L homeolog	Xenopus laevis	30-37
15151257-11	2004	Increased NaDC-1 expression was associated with a decline in urinary citrate excretion.	Citric Acid	69-76	solute carrier family 13 member 2	Rattus norvegicus	10-16
14740109-4	2004	Genetic alterations in the mitochondrial enzyme complex II (SDH), which is involved in respiratory chain and citric acid cycle reactions, have been shown to lead to sporadic as well as familial cases of these tumors.	Citric Acid	109-120	serine dehydratase	Homo sapiens	60-63
15151257-12	2004	Potassium citrate administration could significantly down-regulate NaDC-1 expression and its mRNA, and elevate urinary citrate content alleviate renal pathological changes and reduce nephrolithiasis occurrence.	Citric Acid	10-17	solute carrier family 13 member 2	Rattus norvegicus	67-73
15499218-7	2004	Most filtered citrate is taken up across the apical membrane of the proximal tubule via a sodium-dicarboxylate co-transporter (NaDC-1).	Citric Acid	14-21	solute carrier family 13 member 2	Homo sapiens	127-133
14603493-7	2003	The blood glucose level after administration of the insulin powder without citric acid prepared by the SCF process (MI SCF) decreased rapidly, and a significant difference was observed for areas under the curve of change in plasma glucose concentration versus time (AUCs) between MI SCF and the insulin powder without citric acid prepared by the SD process (MI SD).	Citric Acid	318-329	insulin	Homo sapiens	52-59
14643166-0	2004	Effect of a novel NK1 receptor selective antagonist (NKP608) on citric acid induced cough and airway obstruction.	Citric Acid	64-75	substance-P receptor	Cavia porcellus	18-30
14643166-8	2004	These data show that NKP608, a selective NK1 receptor antagonist, is a potent inhibitor of citric acid induced cough in guinea pigs and may therefore have value in the therapy of clinical cough.	Citric Acid	91-102	substance-P receptor	Cavia porcellus	41-53
14603493-7	2003	The blood glucose level after administration of the insulin powder without citric acid prepared by the SCF process (MI SCF) decreased rapidly, and a significant difference was observed for areas under the curve of change in plasma glucose concentration versus time (AUCs) between MI SCF and the insulin powder without citric acid prepared by the SD process (MI SD).	Citric Acid	318-329	insulin	Homo sapiens	295-302
14603493-5	2003	Insulin powder containing citric acid prepared by the SCF method (MIC SCF) showed improved inhalation performance compared with insulin powder prepared by the SD process, although the particle size of the former powder was larger than that in powders prepared by SD.	Citric Acid	26-37	insulin	Homo sapiens	0-7
14596841-0	2003	Use of citrate to minimize neutrophil matrix metalloproteinase-9 in human plasma.	Citric Acid	7-14	matrix metallopeptidase 9	Homo sapiens	38-64
14603493-5	2003	Insulin powder containing citric acid prepared by the SCF method (MIC SCF) showed improved inhalation performance compared with insulin powder prepared by the SD process, although the particle size of the former powder was larger than that in powders prepared by SD.	Citric Acid	26-37	KIT ligand	Homo sapiens	54-57
14603493-5	2003	Insulin powder containing citric acid prepared by the SCF method (MIC SCF) showed improved inhalation performance compared with insulin powder prepared by the SD process, although the particle size of the former powder was larger than that in powders prepared by SD.	Citric Acid	26-37	KIT ligand	Homo sapiens	70-73
14504133-4	2003	TRA-418 also inhibited platelet aggregation induced by those platelet-stimulants in Ca2+ chelating anticoagulant, citrate and in nonchelating anticoagulant, d-phenylalanyl-l-prolyl-l-arginyl-chloromethyl ketone (PPACK).	Citric Acid	114-121	T cell receptor alpha locus	Homo sapiens	0-3
14551810-9	2003	Significantly, we address the lability of the Fe(3+) coordination shell in nFbp, Fe(3+) nFbp(X) (X=PO(4)(3-), citrate), with respect to exogenous anion (X(n-)) exchange and dissociation, and ultimately complete dissociation of the protein to yield naked (hydrated) Fe(aq)(3+).	Citric Acid	110-117	programmed cell death 11	Homo sapiens	75-79
14636878-4	2003	RESULTS: Heparin and citrate increased S100B levels (p<0.001), whereas EDTA had no effect (p=0.24).	Citric Acid	21-28	S100 calcium binding protein B	Homo sapiens	39-44
12941780-6	2003	In hearts from citrate-treated control rats, angiotensin II-stimulated [(3)H]phenylalanine incorporation and atrial natriuretic peptide and beta-myosin heavy chain mRNA expression were prevented by B-type natriuretic peptide (BNP), bradykinin, the ACE inhibitor ramiprilat, and the neutral endopeptidase inhibitor candoxatrilat.	Citric Acid	15-22	angiotensinogen	Rattus norvegicus	45-59
14575683-7	2003	Citrate was found to be an uncompetitive inhibitor of cMDH and mixed noncompetitive/uncompetitve inhibitor of mMDH.	Citric Acid	0-7	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	110-114
14619957-5	2003	Increases in cytosolic citrate leading to an increase in the concentration of malonyl CoA occur when muscle is presented with insulin and glucose, or when it is made inactive by denervation.	Citric Acid	23-30	insulin	Homo sapiens	126-133
14587005-7	2003	Among cancer samples, larger increases in choline, and decreases in citrate and polyamines (P = 0.05) were observed with more aggressive cancers, and a MIB-1 labeling index correlated (r = 0.62, P = 0.01) with elevated choline.	Citric Acid	68-75	MIB E3 ubiquitin protein ligase 1	Homo sapiens	152-157
14563444-4	2003	RESULTS: Heparin plasma and citrate increased plasma S100B levels (p < 0.001), whereas EDTA had no effect (p = 0.24).	Citric Acid	28-35	S100 calcium binding protein B	Homo sapiens	53-58
12971756-0	2003	Kinetics of metal ion exchange between citric acid and serum transferrin.	Citric Acid	39-50	transferrin	Homo sapiens	61-72
12941780-6	2003	In hearts from citrate-treated control rats, angiotensin II-stimulated [(3)H]phenylalanine incorporation and atrial natriuretic peptide and beta-myosin heavy chain mRNA expression were prevented by B-type natriuretic peptide (BNP), bradykinin, the ACE inhibitor ramiprilat, and the neutral endopeptidase inhibitor candoxatrilat.	Citric Acid	15-22	myosin heavy chain 7	Rattus norvegicus	140-163
12676650-7	2003	Citrate levels increased similarly in glucose-treated MIN6 and GIP/Ins cells.	Citric Acid	0-7	gastric inhibitory polypeptide	Mus musculus	63-66
12941780-6	2003	In hearts from citrate-treated control rats, angiotensin II-stimulated [(3)H]phenylalanine incorporation and atrial natriuretic peptide and beta-myosin heavy chain mRNA expression were prevented by B-type natriuretic peptide (BNP), bradykinin, the ACE inhibitor ramiprilat, and the neutral endopeptidase inhibitor candoxatrilat.	Citric Acid	15-22	natriuretic peptide B	Rattus norvegicus	198-224
12941780-6	2003	In hearts from citrate-treated control rats, angiotensin II-stimulated [(3)H]phenylalanine incorporation and atrial natriuretic peptide and beta-myosin heavy chain mRNA expression were prevented by B-type natriuretic peptide (BNP), bradykinin, the ACE inhibitor ramiprilat, and the neutral endopeptidase inhibitor candoxatrilat.	Citric Acid	15-22	natriuretic peptide B	Rattus norvegicus	226-229
12941780-6	2003	In hearts from citrate-treated control rats, angiotensin II-stimulated [(3)H]phenylalanine incorporation and atrial natriuretic peptide and beta-myosin heavy chain mRNA expression were prevented by B-type natriuretic peptide (BNP), bradykinin, the ACE inhibitor ramiprilat, and the neutral endopeptidase inhibitor candoxatrilat.	Citric Acid	15-22	angiotensin I converting enzyme	Rattus norvegicus	248-251
12826022-1	2003	NaCT (sodium-coupled citrate transporter) is an Na(+)-coupled citrate transporter identified recently in mammals that mediates the cellular uptake of citrate.	Citric Acid	21-28	solute carrier family 13 member 5	Homo sapiens	0-4
12826022-4	2003	Here, we show that NaCT mediates the utilization of extracellular citrate for fat synthesis in human liver cells, and that the process is stimulated by lithium.	Citric Acid	66-73	solute carrier family 13 member 5	Homo sapiens	19-23
12913175-5	2003	Overexpression of a mitochondrial CS (CIT1) in MMYO11 resulted in a 2- to 3-fold increase in citrate levels, and the transformants showed enhanced Al tolerance.	Citric Acid	93-100	citrate (Si)-synthase CIT1	Saccharomyces cerevisiae S288C	38-42
12692122-8	2003	The TRPV4 channel expressed in vitro in Chinese hamster ovary cells was opened by low pH, citrate, and inflation but not by heat or capsaicin.	Citric Acid	90-97	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 4	Cricetulus griseus	4-9
12820873-2	2003	Holo-IRP1 containing a [4Fe-4S] cluster exhibits aconitase activity which catalyzes the isomerization of citrate and isocitrate.	Citric Acid	105-112	aconitase 1	Homo sapiens	5-9
12938993-2	2003	Results showed that electrokinetic process and remediation efficiency varied obviously when different buffer systems, including citric acid (test 1 ) nitric acid + EDTA (test 2) and nitric acid (test 3), were used to control catholyte pH and Na2CO3 was used at the same time to control all anolyte one.	Citric Acid	128-139	serine protease 21	Homo sapiens	141-147
12623203-8	2003	The flux enhancement of insulin in the presence of phthalate buffer was higher in comparison to citrate buffer, but the enhancement in these two buffers was the same in the presence of 0.05 M NaCl, which was also supported by a similar trend in conductivity values.	Citric Acid	96-103	insulin	Homo sapiens	24-31
12730455-8	2003	The changes in m-acon synthesis and abundance in liver during iron deficiency fail to affect TCA-cycle capacity but are associated with a significant upregulation of mitochondrial export of radiolabeled citrate.	Citric Acid	203-210	aconitase 2	Homo sapiens	15-21
12721416-1	2003	This study dealt with the partition behavior and partial purification of hexokinase (HK) from baker"s yeast by liquid-liquid extraction using aqueous two-phase polyethylene glycol (PEG)/citrate systems.	Citric Acid	186-193	hexokinase	Saccharomyces cerevisiae S288C	73-83
12721416-1	2003	This study dealt with the partition behavior and partial purification of hexokinase (HK) from baker"s yeast by liquid-liquid extraction using aqueous two-phase polyethylene glycol (PEG)/citrate systems.	Citric Acid	186-193	hexokinase	Saccharomyces cerevisiae S288C	85-87
12627980-0	2003	Aluminum exchange between citrate and human serum transferrin and interaction with transferrin receptor 1.	Citric Acid	26-33	transferrin	Homo sapiens	50-61
12646708-2	2003	nFbp was reconstituted as a stable iron containing protein by using a number of different exogenous anions [arsenate, citrate, nitrilotriacetate, pyrophosphate, and oxalate (symbolized by X)] in addition to phosphate, predominantly present in the recombinant form of the protein.	Citric Acid	118-125	programmed cell death 11	Homo sapiens	0-4
12636042-5	2003	The Ela/alpha1-PI level is positively correlated with other seminal fluid markers of male genital tract inflammation: reduced semen volume, citric acid, fructose, and increased albumin, complement component C3, caeruloplasmin, immunoglobulins IgG and IgA, and cytokines interleukins-8 and -6.	Citric Acid	140-151	apelin receptor early endogenous ligand	Homo sapiens	4-7
12632503-4	2003	VEGF protein was identified by citrate-microwave SP immunohistochemical method.	Citric Acid	31-38	vascular endothelial growth factor A	Homo sapiens	0-4
12542560-0	2003	Association between vitamin D receptor gene polymorphisms and tubular citrate handling in calcium nephrolithiasis.	Citric Acid	70-77	vitamin D receptor	Homo sapiens	20-38
12542560-3	2003	The aim of this study was to evaluate the relationship between vitamin D receptor (VDR) allelic variant and urinary citrate excretion in recurrent stone formers (SF) patients.	Citric Acid	116-123	vitamin D receptor	Homo sapiens	63-81
12542560-3	2003	The aim of this study was to evaluate the relationship between vitamin D receptor (VDR) allelic variant and urinary citrate excretion in recurrent stone formers (SF) patients.	Citric Acid	116-123	vitamin D receptor	Homo sapiens	83-86
12513074-6	2003	The octahedral environment around each Co(II) is complemented by another singly bonded citrate belonging to the adjacent Co(II) unit and two water molecules.	Citric Acid	87-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-45
12513074-6	2003	The octahedral environment around each Co(II) is complemented by another singly bonded citrate belonging to the adjacent Co(II) unit and two water molecules.	Citric Acid	87-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-127
12513074-11	2003	Collectively, this comprehensive study offers significant structural insight into the Co(II)-citrate speciation and the elucidation of the role of Co(II) in biological fluids.	Citric Acid	93-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
12513074-11	2003	Collectively, this comprehensive study offers significant structural insight into the Co(II)-citrate speciation and the elucidation of the role of Co(II) in biological fluids.	Citric Acid	93-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-92
14991680-2	2003	Relative to an x-ray structure of citrate complexed to the pTyr binding site of the Src SH2 domain, these nonpeptide ligands illustrate the systematic replacement of the phosphate group by multiple nonhydrolyzable, mono- or dianionic functionalities.	Citric Acid	34-41	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	84-87
12519834-9	2003	In addition, during the high-dose insulin clamp, the increase in cytosolic citrate and malate in muscle, which parallels and regulates malonyl CoA levels, was significantly less in the diabetic patients (P < 0.05 vs. P < 0.001).	Citric Acid	75-82	insulin	Homo sapiens	34-41
12524480-9	2003	These data are consistent with the in vivo studies that have shown a redirection of glutamine carbon away from net hepatic glutamate release and into the citric acid cycle through the forward reaction catalyzed by GDH, i.e., glutamate to oxoglutarate.	Citric Acid	154-165	glutamate dehydrogenase 1	Homo sapiens	214-217
12605306-6	2003	The Na(+)-dicarboxylate cotransporter 3 (NaDC-3) was cloned from human, rat, mouse and flounder, and transported three Na(+) with one divalent di- or tricarboxylate, such as citric acid cycle intermediates and the heavy metal chelator 2,3-dimercaptosuccinate (succimer).	Citric Acid	174-185	solute carrier family 13 member 3	Homo sapiens	4-39
12411726-6	2003	Sodium citrate treatment, started at age 1 month, lowered TGF-beta levels to normal in 3-month-old rats, but this is probably not the primary mechanism of citrate"s beneficial effect.	Citric Acid	7-14	transforming growth factor, beta 1	Rattus norvegicus	58-66
12564377-11	2003	The brain Kin was (5-13) x 10(-5), (3-51) x 10(-5), and (2-13) x 10(-5) ml/s/g for 54Mn2+, 54Mn citrate, and 54Mn Tf, respectively.	Citric Acid	96-103	Kin17 DNA and RNA binding protein	Homo sapiens	10-13
12564377-14	2003	When compared to calculated diffusion rates, brain Kin values suggest carrier-mediated brain influx of 54Mn2+, 54Mn citrate and 54Mn Tf.	Citric Acid	116-123	Kin17 DNA and RNA binding protein	Homo sapiens	51-54
12605306-6	2003	The Na(+)-dicarboxylate cotransporter 3 (NaDC-3) was cloned from human, rat, mouse and flounder, and transported three Na(+) with one divalent di- or tricarboxylate, such as citric acid cycle intermediates and the heavy metal chelator 2,3-dimercaptosuccinate (succimer).	Citric Acid	174-185	solute carrier family 13 member 3	Homo sapiens	41-47
12578113-15	2002	The amount of iron mobilized by citrate was directly proportional to the amount of ferritin induced in the A549 cells.	Citric Acid	32-39	Ferritin 1 heavy chain homologue	Drosophila melanogaster	83-91
12445824-5	2002	When functionally expressed in mammalian cells, human NaCT mediates the Na(+)-coupled transport of citrate.	Citric Acid	99-106	solute carrier family 13 member 2	Homo sapiens	54-58
12445824-13	2002	The selectivity of NaCT towards citrate and its predominant expression in the liver suggest that this transporter may facilitate the utilization of circulating citrate for the generation of metabolic energy and for the synthesis of fatty acids and cholesterol.	Citric Acid	32-39	solute carrier family 13 member 2	Homo sapiens	19-23
12445824-13	2002	The selectivity of NaCT towards citrate and its predominant expression in the liver suggest that this transporter may facilitate the utilization of circulating citrate for the generation of metabolic energy and for the synthesis of fatty acids and cholesterol.	Citric Acid	160-167	solute carrier family 13 member 2	Homo sapiens	19-23
12445817-1	2002	Starvation has been associated with a reduced citrate carrier (CTP) activity in rat liver mitochondria.	Citric Acid	46-53	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	63-66
12367768-8	2002	When data of the two groups were combined, urinary citrate excretion was inversely correlated with leucocyte ACL activity (r = 0.6783, p < 0.001).	Citric Acid	51-58	ATP citrate lyase	Homo sapiens	109-112
12374304-4	2002	Incubation with antimycin A, citrate, salicylic acid or at low temperature (10 degrees C) specifically induced the accumulation of the Aox1 isoform.	Citric Acid	29-36	ubiquinol oxidase 1, mitochondrial	Glycine max	135-139
12549788-9	2002	Treatment with PC 2 mEq/kg/day was not able to normalize serum bicarbonate and caused no significant change in the urine citrate/creatinine ratio, and activity production of calcium phosphate stone but it caused a significant decrease in the urine calcium/citrate ratio.	Citric Acid	256-263	chromobox 4	Homo sapiens	15-19
12374304-9	2002	Aox1 induction by citrate, but not by antimycin, was prevented by including the protein kinase inhibitor staurosporine in the medium.	Citric Acid	18-25	ubiquinol oxidase 1, mitochondrial	Glycine max	0-4
12234788-2	2002	We tested the hypothesis that citrate provides acetyl-CoA for malonyl-CoA synthesis after its mitochondrial efflux and cleavage by cytosolic ATP-citrate lyase.	Citric Acid	30-37	ATP citrate lyase	Rattus norvegicus	141-158
21329602-2	2002	METHODS: Fhit protein expression was detected in 92 cases of formalin-fixed, paraffin-embedded human lung cancer by citrate-microwave-SP immunohistochemical method, of which 52 were non-small cell cancer (NSCLC) and 40 small cell cancer (SCLC).	Citric Acid	116-123	fragile histidine triad diadenosine triphosphatase	Homo sapiens	9-13
12198595-5	2002	The key regulatory enzymes directly associated with citrate production in the prostate cells are mitochondrial aspartate aminotransferase, pyruvate dehydrogenase, and mitochondrial aconitase.	Citric Acid	52-59	aconitase 2	Homo sapiens	167-190
12218443-8	2002	CONCLUSIONS: Citrate-coated USPIO particles VSOP-C125 appear to have more favorable properties for magnetic labeling of macrophages than the carboxydextran-coated USPIO preparation DDM 43/34/103.	Citric Acid	13-20	hydrogen voltage gated channel 1	Homo sapiens	44-48
12150972-4	2002	BBG-TCC shows a citrate transport activity.	Citric Acid	16-23	sideroflexin 5	Rattus norvegicus	0-7
12142388-6	2002	RESULTS: The mean (SD) concentrations of free TIMP-1 were similar in citrate [55.5 (11.5) microg/L] and EDTA plasma [58.9 (13.3) microg/L] from 76 donors (r(2) = 0.82).	Citric Acid	69-76	TIMP metallopeptidase inhibitor 1	Homo sapiens	46-52
12362501-5	2002	In blood serum with citrate of 94 angina pectoris patients one found statistically higher E-selectin concentration than in control group.	Citric Acid	20-27	selectin E	Homo sapiens	90-100
12049778-1	2002	Acetyl-CoA synthetase (AceCS) provides acetyl-CoA for different physiological processes, such as fatty acid and cholesterol synthesis, as well as the citric acid cycle.	Citric Acid	150-161	acyl-CoA synthetase long-chain family member 1	Mus musculus	0-21
12049778-1	2002	Acetyl-CoA synthetase (AceCS) provides acetyl-CoA for different physiological processes, such as fatty acid and cholesterol synthesis, as well as the citric acid cycle.	Citric Acid	150-161	acyl-CoA synthetase long-chain family member 1	Mus musculus	23-28
12362501-8	2002	E-selectin was determined in citrate blood serum by ELISA immunoenzymatic method using Bender Medsystems kit.	Citric Acid	29-36	selectin E	Homo sapiens	0-10
12452072-3	2002	METHODS: Fhit protein expression in 66 cases of formalin-fixed, paraffin-embedded breast cancer composed of 6 in situ and 60 invasive ductal carcinoma were detected with citrate-microwave-Streptavidin-HRP(SP) immunohistochemical method, using rabbit antibody to human FHIT gene protein and relationships to invasion and lymphatic metastasis were analyzed.	Citric Acid	170-177	fragile histidine triad diadenosine triphosphatase	Homo sapiens	9-13
12010763-0	2002	Quinine and citric acid elicit distinctive Fos-like immunoreactivity in the rat nucleus of the solitary tract.	Citric Acid	12-23	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	43-46
12010763-1	2002	The present experiment investigated Fos-like immunoreactivity (FLI) in the nucleus of the solitary tract (NST) after intraoral infusions of 0.1 M citric acid, 0.3 M NaCl, and 0.3-30 mM quinine monohydrochloride (QHCl) in awake, behaving rats.	Citric Acid	146-157	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	36-39
12079877-1	2002	Mammals metabolize citrate to acetyl-CoA and oxaloacetate via the enzyme, ATP:citrate lyase.	Citric Acid	19-26	ATP citrate lyase	Homo sapiens	74-91
12019523-3	2002	Oral administration of Al hydroxide [Al (OH)3] or aluminum chloride (AlC13) with citric acid for 7 wk was not found to increase brain Al levels.	Citric Acid	81-92	Alcohol consumption QTL 13	Rattus norvegicus	69-74
12067826-0	2002	Citrate infusion test in the diagnosis of hypocalcemia due to a mutation in the calcium-sensing receptor gene.	Citric Acid	0-7	calcium sensing receptor	Homo sapiens	80-104
12067826-5	2002	When serum calcium was further lowered via a citrate infusion, a significant increase in circulating iPTH was observed, although with lower peak values than in normal controls, suggesting a gain in function of the Ca-R.	Citric Acid	45-52	calcium sensing receptor	Homo sapiens	214-218
12067826-7	2002	The aims of this case report are: (1) to present a mutation in the Ca-R with a gain in function at a codon where previously loss of function was described, and (2) to suggest that measuring circulating iPTH during a citrate infusion in the presence of familial hypocalcemia is an additional test to diagnose this particular form of hypoparathyroidism.	Citric Acid	216-223	calcium sensing receptor	Homo sapiens	67-71
11925455-10	2002	Taken together, our results indicate that the iron-dependent regulation of m-acon in liver does not alter TCA cycle capacity but suggest that IRP-mediated changes in m-acon expression may modulate citrate use in other aspects of intermediary or iron metabolism.	Citric Acid	197-204	caspase 3	Rattus norvegicus	142-145
12419158-2	2002	METHODS: Detecting FHIT protein expression in 60 cases of formalin-fixed, paraffin-embedded colorectal carcinoma by citrate-microwave-SP immunohistochemical method, and analyzing its relationship to histological grade, Dukes" stage and 5-year survival rate.	Citric Acid	116-123	fragile histidine triad diadenosine triphosphatase	Homo sapiens	19-23
11882940-8	2002	In fruit, the increase in LYCes;Ppc2 mRNA was closely followed by an increase in fruit PEPCase protein and activity, and was coincident with the increased accumulation of malate and citrate during the initial period of rapid growth rate, from 8 to 20 days post anthesis.	Citric Acid	182-189	phosphoenolpyruvate carboxylase	Solanum lycopersicum	32-36
12005349-0	2002	Endothelin-1 in citric acid aerosol inhalation-induced airway constriction of guinea pigs.	Citric Acid	16-27	endothelin-1	Cavia porcellus	0-12
11869565-15	2002	If a woman finds cramp troublesome in pregnancy, the best evidence is for magnesium lactate or citrate taken as 5mmol in the morning and 10mmol in the evening.	Citric Acid	95-102	cathelicidin antimicrobial peptide	Homo sapiens	17-22
11762832-13	2002	By decreasing the amount of HCO-60 and citric acid, the PA of G-CSF decreased.	Citric Acid	39-50	colony stimulating factor 3	Canis lupus familiaris	62-67
11851336-4	2002	PEPCK catalyzes the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.	Citric Acid	137-148	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	0-5
11752131-2	2002	SB 235375, a low central nervous system-penetrant, potent and selective neurokinin-3 receptor antagonist, inhibits citric acid-induced cough and airways hyper-reactivity in guinea pigs.	Citric Acid	115-126	neuromedin-K receptor	Cavia porcellus	72-93
11570874-14	2001	Interestingly, human prostatic fluid contains as much as 150 micro mol citrate/g wet weight, which suggests that salt concentrations may regulate PSA activity in vivo.	Citric Acid	71-78	kallikrein related peptidase 3	Homo sapiens	146-149
11896316-1	2002	BACKGROUND: Previous studies indicate that platelet concentrates (PCs) in a platelet additive solution (PAS) containing citrate, acetate, and sodium chloride (PAS-2) show a significantly higher increase of CD62+ platelets than PCs in other brands of PAS containing Mg(2+) and K(+).	Citric Acid	120-127	glycophorin C (Gerbich blood group)	Homo sapiens	159-164
11896316-1	2002	BACKGROUND: Previous studies indicate that platelet concentrates (PCs) in a platelet additive solution (PAS) containing citrate, acetate, and sodium chloride (PAS-2) show a significantly higher increase of CD62+ platelets than PCs in other brands of PAS containing Mg(2+) and K(+).	Citric Acid	120-127	selectin P	Homo sapiens	206-210
11803399-5	2001	We have determined the level of C3a (the most reactive complement component) generated in isolated citrate plasma of healthy individuals after challenge with recombinant and wild-type adenoviruses in amounts corresponding to virus blood levels to be expected in patients during adenoviral gene therapy.	Citric Acid	99-106	complement C3	Homo sapiens	32-35
11729363-3	2001	Enhanced GP IIb/IIIa binding and inhibition of platelet aggregation for eptifibatide secondary to citrate induced reduction of ionized plasma calcium concentrations has been reported.	Citric Acid	98-105	integrin subunit alpha 2b	Homo sapiens	9-15
11729363-5	2001	The decrease in ionized calcium afforded by citrate was associated with enhanced in vitro platelet inhibition for all three GP IIb/IIIa inhibitors, including abciximab.	Citric Acid	44-51	integrin subunit alpha 2b	Homo sapiens	124-130
11513726-5	2001	Here we describe the crystal structure of the PtdIns(3,4)P(2)-binding PH domain of TAPP1 at 1.4 A (1 A=0.1 nm) resolution in complex with an ordered citrate molecule.	Citric Acid	149-156	pleckstrin homology domain containing A1	Homo sapiens	83-88
11762790-8	2001	Urinary potassium and citrate excretion increased with potassium citrate (Period 2).	Citric Acid	22-29	period circadian regulator 2	Homo sapiens	74-82
11471731-5	2001	In 20 mm phosphate and citrate at pH 7.0, the results are similar, i.e., EPO suffered a substantial aggregation, while it showed little aggregation in 20 mm Tris or histidine at pH 7.0 and 20 mm glycine at pH 6.3 under identical heat treatment.	Citric Acid	23-30	erythropoietin	Homo sapiens	73-76
11758258-9	2001	The ratio hNaDC1 mRNA/18sRNA in the patients with normal urine citrate was not significantly different from that in the controls (P > 0.05).	Citric Acid	63-70	solute carrier family 13 member 2	Homo sapiens	10-16
12604013-9	2001	When LMWH was used in combination with citrate we observed a decrease in basal activation and significant modifications in CD11b expression induced by shear stress (80.0±4.1 vs. 50.4±2.7).	Citric Acid	39-46	integrin subunit alpha M	Homo sapiens	123-128
11399753-1	2001	The Na(+)/dicarboxylate co-transporter, NaDC-1, couples the transport of sodium and Krebs cycle intermediates, such as succinate and citrate.	Citric Acid	133-140	solute carrier family 13 member 2	Homo sapiens	40-46
11522542-2	2001	Hitherto sampling for prothrombin time (PT) has been measured on blood collected into a coagulation tube and diluted in citrate solution.	Citric Acid	120-127	coagulation factor II, thrombin	Homo sapiens	22-33
11467696-4	2001	The determination of citrate plasma soluble P-selectin levels throughout pregnancy was performed using a commercial quantitative sandwich immunoassay kit.	Citric Acid	21-28	selectin P	Homo sapiens	44-54
11716369-3	2001	Using a CdS/AgS ion selective electrode to measure [Cd2+] in physiological saline solution at pH 7.4, we show that Fe2+ promotes Cd2+ binding to citrate thereby decreasing the availability of free Cd2+.	Citric Acid	145-152	CD2 molecule	Homo sapiens	129-132
11716369-3	2001	Using a CdS/AgS ion selective electrode to measure [Cd2+] in physiological saline solution at pH 7.4, we show that Fe2+ promotes Cd2+ binding to citrate thereby decreasing the availability of free Cd2+.	Citric Acid	145-152	CD2 molecule	Homo sapiens	129-132
11457470-3	2001	Also, anticoagulation [citrate vs. D-phenylalanyl-1-prolyl-1 arginine chloromethyl ketone (PPACK)] was varied to enhance the functions of GP Ia/IIa, since it has been shown that the cation-poor environment of citrated blood impairs GP Ia/IIa-dependent platelet recruitment.	Citric Acid	23-30	multimerin 1	Homo sapiens	138-143
11481570-10	2001	CONCLUSIONS: BMIPP imaging correlates well with the activities of HAD and CS, suggesting that a decrease in BMIPP uptake reflects deterioration of both fatty acid metabolism and citrate cycle and shows information other than regional myocardial perfusion.	Citric Acid	178-185	citrate synthase	Rattus norvegicus	74-76
11356166-9	2001	We develop the hypothesis that PDK4 is a "lipid status"-responsive PDK isoform facilitating FA oxidation and signalling through citrate formation.	Citric Acid	128-135	pyruvate dehydrogenase kinase 4	Homo sapiens	31-35
11380429-6	2001	Both serum and citrate samples are suitable for the detection of aPT.	Citric Acid	15-22	LYPLA2 pseudogene 1	Homo sapiens	65-68
11259450-4	2001	AR (heated citrate buffer, pH 6.0, LR White resin) increased the amount of label of collagen IV and fibronectin in tissue fixed in four different fixatives, including those containing glutaraldehyde.	Citric Acid	11-18	fibronectin 1	Homo sapiens	100-111
11442063-1	2001	The iron-sulfur protein is an essential component of mitochondrial complex II (succinate dehydrogenase, SDH), which is a functional enzyme of both the citric acid cycle and the respiratory electron transport chain.	Citric Acid	151-162	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	104-107
11341499-6	2001	Shortening of the prothrombin time was also observed when magnesium chloride was added to dialysed plasma, i.e., in the absence of citrate.	Citric Acid	131-138	coagulation factor II, thrombin	Homo sapiens	18-29
11341505-2	2001	First the monoclonal antibody (MoAb) 9C8, raised against human platelet GPIbalpha, dose-dependently induced platelet aggregation of citrate-anticoagulated platelet-rich plasma, an effect that can be inhibited by several activation inhibitors.	Citric Acid	132-139	glycoprotein Ib platelet subunit alpha	Homo sapiens	72-81
11341513-3	2001	Similar studies using citrate anticoagulated blood showed that this was due to fibrinogen and not fibrin.	Citric Acid	22-29	fibrinogen beta chain	Homo sapiens	79-89
11241046-1	2001	OBJECTIVES: To quantify urinary citrate and calcium excretion and systemic acid-base status in patients with type 1a glycogen storage disease (GSD1a) and to investigate their relationship to renal complications.	Citric Acid	32-39	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	143-148
11237858-7	2001	A large positive inotropic (contraction-intensifying) effect of loading the Mg2+ chelator citrate, via its acetoxymethyl ester, into the heart has confirmed the competitive inhibition of the Ca2+ activation by Mg2+, previously seen in vitro.	Citric Acid	90-97	mucin 7, secreted	Homo sapiens	76-79
11237858-7	2001	A large positive inotropic (contraction-intensifying) effect of loading the Mg2+ chelator citrate, via its acetoxymethyl ester, into the heart has confirmed the competitive inhibition of the Ca2+ activation by Mg2+, previously seen in vitro.	Citric Acid	90-97	mucin 7, secreted	Homo sapiens	210-213
11083877-10	2001	Adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate were also transported by the human ODC.	Citric Acid	103-110	solute carrier family 25 member 21	Homo sapiens	146-149
11241046-6	2001	Normally, urinary citrate excretion increases with age; however, in patients with GSD1a, a strong inverse exponential relationship was found between age and citrate excretion (r = -0.84, P <.0001).	Citric Acid	18-25	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	82-87
11241046-6	2001	Normally, urinary citrate excretion increases with age; however, in patients with GSD1a, a strong inverse exponential relationship was found between age and citrate excretion (r = -0.84, P <.0001).	Citric Acid	157-164	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	82-87
11241046-11	2001	Citrate supplementation may be beneficial in preventing or ameliorating nephrocalcinosis and the development of urinary calculi in GSD1a.	Citric Acid	0-7	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	131-136
11307828-10	2001	CONCLUSIONS: These data confirm previous observations that Ca2+ chelation afforded by citrate decreases the effective inhibitor concentrations of GPIIb/IIIa antagonists, as assessed by turbidimetric platelet aggregation.	Citric Acid	86-93	integrin subunit alpha 2b	Homo sapiens	146-151
11160511-11	2001	For citric acid-best neurons, the magnitude of inhibition produced by CeA activation increased with an increase in stimulus effectiveness.	Citric Acid	4-15	CEA cell adhesion molecule 3	Homo sapiens	70-73
11468010-3	2001	The aim of this work was to assess in pigs the effects of bradykinin and tachykinins on citric-acid-induced coughing after ACE inhibitor pretreatment.	Citric Acid	88-99	angiotensin-converting enzyme	Sus scrofa	123-126
11162899-2	2000	The metabolic pathway for citrate production in the prostate involves the activity of mitochondrial aspartate aminotransferase (mAAT).	Citric Acid	26-33	serine (or cysteine) preptidase inhibitor, clade A, member 1B	Mus musculus	128-132
11310216-2	2001	To examine the effect of citrate on the matrix, we investigated the effect of citrate on osteopontin (OPN) expression, which we had previously identified as an important stone matrix protein.	Citric Acid	78-85	secreted phosphoprotein 1	Rattus norvegicus	89-100
11310216-2	2001	To examine the effect of citrate on the matrix, we investigated the effect of citrate on osteopontin (OPN) expression, which we had previously identified as an important stone matrix protein.	Citric Acid	78-85	secreted phosphoprotein 1	Rattus norvegicus	102-105
11310216-5	2001	This was associated with a low expression of OPN mRNA in citrate-treated rats relative to that in the stone group.	Citric Acid	57-64	secreted phosphoprotein 1	Rattus norvegicus	45-48
11310216-6	2001	Citrate was effective in preventing calcium oxalate stone formation and reduced OPN expression in rats.	Citric Acid	0-7	secreted phosphoprotein 1	Rattus norvegicus	80-83
11310216-7	2001	Our results suggest that citrate prevents renal stone formation by acting against not only the crystal aggregation and growth of calcium oxalate but also OPN expression.	Citric Acid	25-32	secreted phosphoprotein 1	Rattus norvegicus	154-157
11835418-3	2001	Citrate-based anticoagulants, notably sodium citrate and ACD formula A, have been indicated as the major cause of hypocalcemic toxicity, but colloid replacement fluids containing human serum albumin are also at fault.	Citric Acid	0-7	albumin	Homo sapiens	185-198
11201340-0	2001	Preparation of PEG-grafted immunomagnetoliposomes entrapping citrate stabilized magnetite particles and their application in CD34+ cell sorting.	Citric Acid	61-68	CD34 molecule	Homo sapiens	125-129
11085915-5	2000	By means of an Fe-S-cluster-dependent switch, IRP-1 can function as an mRNA-binding protein or as an enzyme that converts citrate into isocitrate.	Citric Acid	122-129	aconitase 1	Homo sapiens	46-51
11161786-5	2000	Expression of hNaSi-1 protein in Xenopus oocytes demonstrated a high-affinity Na+-sulfate cotransporter that was inhibited by selenate, thiosulfate, molybdate, tungstate, citrate, and succinate.	Citric Acid	171-178	solute carrier family 13 member 1	Homo sapiens	14-21
11171137-1	2000	ATP citrate lyase (ACL) catalyses the ATP-dependent reaction between citrate and CoA to form oxaloacetate and acetyl-CoA.	Citric Acid	4-11	acetone-cyanohydrin lyase	Arabidopsis thaliana	19-22
11033232-3	2000	Treatment with citrate and aluminum plus citrate increased ALA-D activity in vivo and the increase in enzyme activity was parallel to the increase in aluminum content in blood and plasma.	Citric Acid	15-22	aminolevulinate, delta-, dehydratase	Mus musculus	59-64
11033232-3	2000	Treatment with citrate and aluminum plus citrate increased ALA-D activity in vivo and the increase in enzyme activity was parallel to the increase in aluminum content in blood and plasma.	Citric Acid	41-48	aminolevulinate, delta-, dehydratase	Mus musculus	59-64
10966927-1	2000	The sodium-dicarboxylate cotransporter of the renal proximal tubule, NaDC-1, reabsorbs filtered Krebs cycle intermediates and plays an important role in the regulation of urinary citrate concentrations.	Citric Acid	179-186	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2	Mus musculus	69-75
12549038-3	2000	Citrate synthase plays a key role in regulating TCA cycle and is responsible for catalysing the synthesis of citrate from oxaloacetate and acetyl CoA.	Citric Acid	109-116	citrate synthase	Homo sapiens	0-16
10974231-3	2000	RESULTS: A significantly higher IC50s was shown with heparin (free ionized calcium=1.1 mM) as compared to that with citrate (free ionized calcium=0.12 mM) with class II GPIIb/IIIa antagonists (P<0.01) such as Orbofiban, and Integrilin.	Citric Acid	116-123	integrin subunit alpha 2b	Homo sapiens	169-174
10962094-7	2000	Citrate, also a major component of seminal and prostatic fluid, spermine, and spermidine each protect rPSA from Zn(2+) inhibition, presumably via Zn(2+) sequestration.	Citric Acid	0-7	aminopeptidase puromycin sensitive	Rattus norvegicus	102-106
10962087-0	2000	The citrate ion increases the conformational stability of alpha(1)-antitrypsin.	Citric Acid	4-11	serpin family A member 1	Homo sapiens	58-78
11019963-1	2000	Oral anticoagulant therapy is usually monitored with the prothrombin time (PT) on citrate plasma samples.	Citric Acid	82-89	coagulation factor II, thrombin	Homo sapiens	57-68
10944103-1	2000	The structure of L-amino acid oxidase (LAAO) from Calloselasma rhodostoma has been determined to 2.0 A resolution in the presence of two ligands: citrate and o-aminobenzoate (AB).	Citric Acid	146-153	interleukin 4 induced 1	Homo sapiens	17-37
10962087-4	2000	alpha(1)-Antitrypsin was fully active in the presence of a range of citrate concentrations (0.	Citric Acid	68-75	serpin family A member 1	Homo sapiens	0-20
10962087-6	2000	The association rate constant between alpha(1)-antitrypsin and chymotrypsin was decreased with increasing citrate concentration.	Citric Acid	106-113	serpin family A member 1	Homo sapiens	38-58
10962087-8	2000	However, the insertion rate of exogenous reactive-center loop peptide increased with increasing citrate concentration, indicating some structural changes in the A beta-sheet region.	Citric Acid	96-103	amyloid beta precursor protein	Homo sapiens	161-167
10962087-9	2000	Taken together, these data suggest that in the presence of 0.5 M citrate alpha(1)-antitrypsin adopts a highly stable but active conformation.	Citric Acid	65-72	serpin family A member 1	Homo sapiens	73-93
10944103-1	2000	The structure of L-amino acid oxidase (LAAO) from Calloselasma rhodostoma has been determined to 2.0 A resolution in the presence of two ligands: citrate and o-aminobenzoate (AB).	Citric Acid	146-153	interleukin 4 induced 1	Homo sapiens	39-43
10971117-4	2000	Then, the PG was treated with citrate buffer at pH 3.0 for 5 min to liberate IgE from IgG-IgE complexes, after IgG-binding sites on the PG were saturated with bovine IgG, since PG came to bind IgE at acidic pHs.	Citric Acid	30-37	immunoglobulin heavy constant epsilon	Homo sapiens	77-80
10944210-3	2000	Based on a cocrystal structure of the noncatalytic Src homology 2 (SH2) domain of Src complexed with citrate [in the phosphotyrosine (pTyr) binding pocket], we designed 3",4"-diphosphonophenylalanine (Dpp) as a pTyr mimic.	Citric Acid	101-108	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	51-54
10944210-3	2000	Based on a cocrystal structure of the noncatalytic Src homology 2 (SH2) domain of Src complexed with citrate [in the phosphotyrosine (pTyr) binding pocket], we designed 3",4"-diphosphonophenylalanine (Dpp) as a pTyr mimic.	Citric Acid	101-108	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	82-85
10994634-12	2000	ELISA results indicate that UEC secrete IL-1alpha constitutively in citro.	Citric Acid	68-73	interleukin 1 alpha	Rattus norvegicus	40-49
10971117-4	2000	Then, the PG was treated with citrate buffer at pH 3.0 for 5 min to liberate IgE from IgG-IgE complexes, after IgG-binding sites on the PG were saturated with bovine IgG, since PG came to bind IgE at acidic pHs.	Citric Acid	30-37	immunoglobulin heavy constant epsilon	Homo sapiens	86-93
10971117-4	2000	Then, the PG was treated with citrate buffer at pH 3.0 for 5 min to liberate IgE from IgG-IgE complexes, after IgG-binding sites on the PG were saturated with bovine IgG, since PG came to bind IgE at acidic pHs.	Citric Acid	30-37	immunoglobulin heavy constant epsilon	Homo sapiens	90-93
10940744-7	2000	RESULTS: The use of citrate at a high concentration (10 mmol/l) was associated with a blunted upregulation of CD11b, both at the inlet and at the outlet bloodline; for CD11c a reduced upregulation was observed on granulocytes harvested from the inlet bloodline.	Citric Acid	20-27	integrin subunit alpha M	Homo sapiens	110-115
10968618-4	2000	In an effort to unravel the aqueous chemistry of cobalt in the presence of a physiologically relevant ligand, citrate, the first aqueous, soluble, mononuclear complex has been synthesized and isolated from reaction mixtures containing Co(II) and citrate in a 1:2 molar ratio at pH approximately 8.	Citric Acid	110-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	235-241
10968618-6	2000	Its X-ray structure consists of a distorted octahedral anion with two citrate ligands fulfilling the coordination requirements of the Co(II) ion.	Citric Acid	70-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-140
10940744-7	2000	RESULTS: The use of citrate at a high concentration (10 mmol/l) was associated with a blunted upregulation of CD11b, both at the inlet and at the outlet bloodline; for CD11c a reduced upregulation was observed on granulocytes harvested from the inlet bloodline.	Citric Acid	20-27	integrin subunit alpha X	Homo sapiens	168-173
10781268-14	2000	After 30 min of citrate storage a gradual thrombin activation was observed, as evidenced by increasing thrombin-antithrombin complex and prothrombin fragment 1+2 values (P < 0.05).	Citric Acid	16-23	coagulation factor II, thrombin	Homo sapiens	42-50
10894787-7	2000	The preferred substrates of hNaDC-1 are fumarate (K(0.5) 1.8 mM) and succinate, followed by methylsuccinate (K(0.5) 2.8 mM), citrate (K(0.	Citric Acid	125-132	solute carrier family 13 member 2	Homo sapiens	28-35
10845608-6	2000	CONCLUSIONS: Insulin antagonizes GC-induced gluconeogenesis, stimulates glycolysis, and ultimately leads to recovery of decreased activity in the citric acid cycle.	Citric Acid	146-157	insulin	Gallus gallus	13-20
10860730-4	2000	The crystal structure of IFN-gamma SC1 has been determined at 2.9 A resolution from crystals grown in 1.4 M citrate solutions at pH 7.6.	Citric Acid	108-115	interferon gamma	Homo sapiens	25-34
10860730-4	2000	The crystal structure of IFN-gamma SC1 has been determined at 2.9 A resolution from crystals grown in 1.4 M citrate solutions at pH 7.6.	Citric Acid	108-115	transcription factor 19	Homo sapiens	35-38
10799480-2	2000	Mitochondrial aconitase (m-aconitase) contains a [4Fe-4S](2+) cluster in its active site that catalyzes the stereospecific dehydration-rehydration of citrate to isocitrate in the Krebs cycle.	Citric Acid	150-157	aconitase 2	Homo sapiens	0-23
10799480-2	2000	Mitochondrial aconitase (m-aconitase) contains a [4Fe-4S](2+) cluster in its active site that catalyzes the stereospecific dehydration-rehydration of citrate to isocitrate in the Krebs cycle.	Citric Acid	150-157	aconitase 2	Homo sapiens	25-36
10794676-8	2000	Simultaneous measurements of succinate-evoked charge transfer and radiolabeled succinate uptake in hNaDC3-expressing oocytes indicate a charge-to-succinate ratio of 1:1 for the transport process, suggesting a Na(+)-to-succinate stoichiometry of 3:1. pH titration of citrate-induced currents shows that hNaDC3 accepts preferentially the divalent anionic form of citrate as a substrate.	Citric Acid	266-273	solute carrier family 13 member 3	Homo sapiens	99-105
10794676-8	2000	Simultaneous measurements of succinate-evoked charge transfer and radiolabeled succinate uptake in hNaDC3-expressing oocytes indicate a charge-to-succinate ratio of 1:1 for the transport process, suggesting a Na(+)-to-succinate stoichiometry of 3:1. pH titration of citrate-induced currents shows that hNaDC3 accepts preferentially the divalent anionic form of citrate as a substrate.	Citric Acid	361-368	solute carrier family 13 member 3	Homo sapiens	99-105
10781268-14	2000	After 30 min of citrate storage a gradual thrombin activation was observed, as evidenced by increasing thrombin-antithrombin complex and prothrombin fragment 1+2 values (P < 0.05).	Citric Acid	16-23	coagulation factor II, thrombin	Homo sapiens	103-111
10781268-15	2000	beta-Thromboglobulin level was increased after 2 and 8 h of citrate storage (P < 0.01).	Citric Acid	60-67	pro-platelet basic protein	Homo sapiens	0-20
10640321-2	2000	Parenteral administration of selective agonists of the delta-opioid receptor (SB 227122), mu-opioid receptor (codeine and hydrocodone), and kappa-opioid receptor (BRL 52974) produced dose-related inhibition of citric acid-induced cough with ED(50) values of 7.3, 5.2, 5.1, and 5.3 mg/kg, respectively.	Citric Acid	210-221	mu-type opioid receptor	Cavia porcellus	90-108
10759602-3	2000	In heart muscle, depletion of the citric acid cycle (TCA cycle) through a block of 2-oxoglutarate dehydrogenase results in a rapid decline of contractile function, which is reversed by the addition of substrates promoting flux through the carboxylating enzymes, malic enzyme, pyruvate carboxylase and propionyl-CoA carboxylase.	Citric Acid	34-45	pyruvate carboxylase	Homo sapiens	276-296
10759520-1	2000	ATP:citrate lyase (ACL) catalyzes the conversion of citrate to acetyl-coenzyme A (CoA) and oxaloacetate and is a key enzyme for lipid accumulation in mammals and oleaginous yeasts and fungi.	Citric Acid	4-11	ATP citrate lyase	Rattus norvegicus	19-22
10937051-8	2000	Boric acid was used for antigen retrieval on sections stored for 12 weeks at 20 degrees C. For both p53 protein and MIB1 antigen, this resulted in an extent and intensity of immunostaining equal to or higher than (MIB1) that obtained in freshly cut sections, using citrate buffer.	Citric Acid	265-272	tumor protein p53	Homo sapiens	100-103
10937051-8	2000	Boric acid was used for antigen retrieval on sections stored for 12 weeks at 20 degrees C. For both p53 protein and MIB1 antigen, this resulted in an extent and intensity of immunostaining equal to or higher than (MIB1) that obtained in freshly cut sections, using citrate buffer.	Citric Acid	265-272	MIB E3 ubiquitin protein ligase 1	Homo sapiens	116-120
10691965-14	2000	These results suggest that MTf played only a minor role in Fe uptake from 59Fe-citrate by these cells.	Citric Acid	79-86	melanotransferrin	Homo sapiens	27-30
10675755-4	2000	In contrast, TNF-alpha concentrations obtained from PHA and LPS stimulated whole blood cultures from citrate-treated blood did not show a correlation.	Citric Acid	101-108	tumor necrosis factor	Homo sapiens	13-22
10675755-5	2000	We also found that the PHA stimulated TNF-alpha response was significantly higher in PBMC than in whole blood cultures, whereas the highest LPS stimulated TNF-alpha response was observed in citrate-treated blood.	Citric Acid	190-197	tumor necrosis factor	Homo sapiens	155-164
10675755-6	2000	Moreover, the TNF-alpha response in both, citrate and EDTA treated whole blood cultures was significantly higher after LPS than after PHA stimulation.	Citric Acid	42-49	tumor necrosis factor	Homo sapiens	14-23
10639190-5	2000	Previous animal studies demonstrated that testosterone and prolactin regulate the level of m-aconitase specifically in citrate-producing prostate cells.	Citric Acid	119-126	prolactin	Homo sapiens	59-68
10648272-9	2000	The percentage increase in serum PTH during citrate-induced hypocalcemia was lower in the TPN recipients, consistent with secondary hyperparathyroidism.	Citric Acid	44-51	parathyroid hormone	Homo sapiens	33-36
10640321-2	2000	Parenteral administration of selective agonists of the delta-opioid receptor (SB 227122), mu-opioid receptor (codeine and hydrocodone), and kappa-opioid receptor (BRL 52974) produced dose-related inhibition of citric acid-induced cough with ED(50) values of 7.3, 5.2, 5.1, and 5.3 mg/kg, respectively.	Citric Acid	210-221	kappa-type opioid receptor	Cavia porcellus	140-161
11182632-11	2000	Lower leptin measurements in citrate-treated plasma may partially, but not in total, be a consequence of dilution by anticoagulating additives.	Citric Acid	29-36	leptin	Homo sapiens	6-12
11271829-4	2000	These mutants showed a 40% lower LDH activity than the wild type grown at 5 degrees C that was comparable to the wild type grown at 15 degrees C. High specific activity of succinic dehydrogenase (SDH) at 28 degrees C in both strains and mutants indicated that aerobic respiration via the citrate cycle is the normal mode of saccharide utilization.	Citric Acid	288-295	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	172-194
11271829-4	2000	These mutants showed a 40% lower LDH activity than the wild type grown at 5 degrees C that was comparable to the wild type grown at 15 degrees C. High specific activity of succinic dehydrogenase (SDH) at 28 degrees C in both strains and mutants indicated that aerobic respiration via the citrate cycle is the normal mode of saccharide utilization.	Citric Acid	288-295	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	196-199
10602269-1	2000	Citrate synthase is a key regulatory metabolic enzyme that catalyzes the first step in the tricarboxylic acid (TCA) cycle, the synthesis of citrate from acetyl coenzyme A and oxaloacetate.	Citric Acid	140-147	citrate synthase	Bos taurus	0-16
10898885-3	2000	The liquid phase of CP-1 and CP-2 was a solution containing tannic acid and citric acid.	Citric Acid	76-87	cathepsin L	Rattus norvegicus	29-33
10590185-12	2000	These findings indicate that dosing regimens for GPIIb/IIIa receptor antagonists based on the platelet inhibition profile in citrate may provide misleading information with respect to their true in vivo antithrombotic efficacy.	Citric Acid	125-132	integrin subunit alpha 2b	Homo sapiens	49-54
10616843-5	2000	In untreated diabetic rats, there were significant increases in blood glucose, urine albumin excretion, kidney weight, glomerular volume, and TGF-beta1 mRNA expression in the glomeruli compared with normal control rats treated with citrate buffer only.	Citric Acid	232-239	transforming growth factor, beta 1	Rattus norvegicus	142-151
10670033-9	1999	Using the citric acid technique the average concentration of RANTES in middle turbinates was 1.3 ng/mg, in inferior turbinates 1.6 ng/mg and in polyps 2.6 ng/mg tissue, using the PBS technique respectively 0.6 ng/mg, 0.5 ng/mg and 0.8 ng/mg tissue.	Citric Acid	10-21	C-C motif chemokine ligand 5	Homo sapiens	61-67
10631981-1	1999	The crystal structure of the S642A mutant of mitochondrial aconitase (mAc) with citrate bound has been determined at 1.8 A resolution and 100 K to capture this binding mode of substrates to the native enzyme.	Citric Acid	80-87	aconitase 2	Homo sapiens	45-68
10582722-10	1999	Neutrophils in citrate-blood increased their ability to respond to fMLP, as compared with EDTA-blood.	Citric Acid	15-22	formyl peptide receptor 1	Homo sapiens	67-71
10556622-4	1999	Interestingly, iron also positively affects three other citric acid cycle enzymes, namely citrate synthase, isocitric dehydrogenase, and succinate dehydrogenase, while DFO decreases the activity of these enzymes.	Citric Acid	56-67	citrate synthase	Homo sapiens	90-106
10597025-7	1999	Namely, at the beginning of evolution methylglyoxalase path was essential for the reductive citric acid cycle as an anaplerotic route, while in the extant metabolism it concerns with the detoxification of methylglyoxal and plays some regulatory role in triose-phosphate household.	Citric Acid	92-103	glyoxalase I	Homo sapiens	38-54
10555083-1	1999	The role of citric acid in a simulated body fluid (SBF) was examined with the main focus on its induction ability of hydroxyapatite (HAp) nucleation on a bioinert collagen membrane.	Citric Acid	12-23	reticulon 3	Homo sapiens	133-136
11869534-2	1999	METHODS: Reverse transcription-polymerase chain reaction (RT-PCR) and citric acid-microwave-ABC immunohistochemistry (ICH) were used to observe mRNA transcription forms and protein distributions of bcl-x in 30 frozen tissues and 109 paraffin embedded tissues (both including reactive hyperplasia and common types of lymphoma).	Citric Acid	70-81	BCL2 like 1	Homo sapiens	198-203
10541277-3	1999	Calcium oxalate monohydrate and hydroxyapatite (calcium phosphate) crystals rapidly adhere to anionic sites on the surface of cultured renal epithelial cells, but this process is inhibited by specific urinary anions such as citrate, glycosaminoglycans, uropontin, or nephrocalcin, each of which can coat the crystals.	Citric Acid	224-231	secreted phosphoprotein 1	Homo sapiens	253-262
10529440-5	1999	Histological analysis revealed a significant reduction in the number of cell bodies immunostained for tyrosine hydroxylase (TH+) within the transplant for those animals pretreated with an intrastriatal injection of citrate buffer and subsequently given either dose of 6-OHDA.	Citric Acid	215-222	tyrosine hydroxylase	Rattus norvegicus	102-122
10529440-6	1999	Transplanted animals pretreated with GDNF and subsequently administered 8.0 microg of 6-OHDA showed a significant reduction of TH+ neurons within the transplant compared to controls, however TH+ cell counts for this group remained significantly higher than the TH+ cell counts for the group of animals receiving the same dose of 6-OHDA but pretreated with citrate buffer.	Citric Acid	356-363	glial cell derived neurotrophic factor	Rattus norvegicus	37-41
10529440-9	1999	For both groups of transplanted animals receiving GDNF pretreatment and 6-OHDA injections, amphetamine-induced rotational scores dropped below the scores for animals pretreated with citrate buffer but remained significantly higher than the scores for transplanted animals that were not injected with 6-OHDA.	Citric Acid	182-189	glial cell derived neurotrophic factor	Rattus norvegicus	50-54
10446305-1	1999	The Na(+)/dicarboxylate cotransporter of the renal proximal tubule, NaDC-1, reabsorbs Krebs cycle intermediates, such as succinate and citrate, from the tubular filtrate.	Citric Acid	135-142	solute carrier family 13 member 2L homeolog	Xenopus laevis	68-74
10544213-8	1999	Antigen retrieval using SDS and citrate buffer substantially increased ODC immunostaining and decreased background staining.	Citric Acid	32-39	ornithine decarboxylase 1	Rattus norvegicus	71-74
10604256-7	1999	RESULTS: The plasma samples anticoagulated with 6-percent citrate contained significantly higher levels of factors V, VIII, and IX than the samples anticoagulated with 8-percent citrate (p<0.0001, p< or =0.0001 and p = 0.009, respectively).	Citric Acid	58-65	cytochrome c oxidase subunit 8A	Homo sapiens	118-122
10604256-10	1999	CONCLUSION: A reduction in the final citrate concentration of plasma collected by automated plasmapheresis results in higher yields of factors V, VIII, and IX without activation of hemostasis.	Citric Acid	37-44	cytochrome c oxidase subunit 8A	Homo sapiens	146-150
10482501-8	1999	Although PrpC could use acetyl-CoA as a substrate to synthesize citrate, kinetic analysis demonstrated that propionyl-CoA is the preferred substrate.	Citric Acid	64-71	2-methylcitrate synthase	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	9-13
10482502-10	1999	Regulation studies with a dctA-lacZ (f428-lacZ) transcriptional fusion showed that dctA is subject to cyclic AMP receptor protein (CRP)-dependent catabolite repression and ArcA-mediated anaerobic repression and is weakly induced by the DcuS-DcuR system in response to C(4)-dicarboxylates and citrate.	Citric Acid	292-299	catabolite gene activator protein	Escherichia coli	102-129
10482502-10	1999	Regulation studies with a dctA-lacZ (f428-lacZ) transcriptional fusion showed that dctA is subject to cyclic AMP receptor protein (CRP)-dependent catabolite repression and ArcA-mediated anaerobic repression and is weakly induced by the DcuS-DcuR system in response to C(4)-dicarboxylates and citrate.	Citric Acid	292-299	catabolite gene activator protein	Escherichia coli	131-134
10482502-10	1999	Regulation studies with a dctA-lacZ (f428-lacZ) transcriptional fusion showed that dctA is subject to cyclic AMP receptor protein (CRP)-dependent catabolite repression and ArcA-mediated anaerobic repression and is weakly induced by the DcuS-DcuR system in response to C(4)-dicarboxylates and citrate.	Citric Acid	292-299	arginine deiminase	Escherichia coli	172-176
10488562-5	1999	Reaction is insensitive to the concentration of monovalent cations but is completely prevented by chelating agents (EDTA and citrate) at concentrations exceeding that of Mg2+.	Citric Acid	125-132	mucin 7, secreted	Homo sapiens	170-173
10393170-3	1999	We determined crystal structures for APRT from Leishmania donovani in complex with the substrate adenine, the product AMP, and sulfate and citrate ions that appear to mimic the binding of phosphate moieties.	Citric Acid	139-146	adenine phosphoribosyltransferase	Leishmania donovani	37-41
10408859-2	1999	The ELISA enabled specific detection of total TIMP-1 in EDTA, citrate and heparin plasma.	Citric Acid	62-69	TIMP metallopeptidase inhibitor 1	Homo sapiens	46-52
10402815-3	1999	2) We evaluated the effect of citrate on Mg2+ and Ca2+ in vitro.	Citric Acid	30-37	mucin 7, secreted	Homo sapiens	41-44
10402815-6	1999	Mean value of post-operative citrate concentration of patients with blood transfusion was 0.15 +/- 0.11 mmol.l-1, and this value decreased Mg2+ about 2% in in vitro study.	Citric Acid	29-36	mucin 7, secreted	Homo sapiens	139-142
10320342-1	1999	The Na+/dicarboxylate cotransporter (NaDC-1) couples the transport of sodium and tricarboxylic acid cycle intermediates, such as succinate and citrate.	Citric Acid	143-150	solute carrier family 13 member 2	Homo sapiens	37-43
10408859-4	1999	TIMP-1 levels measured in citrate plasma (mean 69.2+/-13.1 microg I(-1)) correlated with TIMP-1 measured in EDTA plasma (mean 73.5+/-14.2 microg I(-1)) from the same individuals in a set of 100 healthy blood donors (Spearman"s rho = 0.62, P< 0.0001).	Citric Acid	26-33	TIMP metallopeptidase inhibitor 1	Homo sapiens	0-6
10207168-9	1999	SDCT2 expressed in Xenopus oocytes mediated sodium-dependent transport of di- and tricarboxylates with substrate preference for succinate rather than citrate, but excluding monocarboxylates.	Citric Acid	150-157	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 L homeolog	Xenopus laevis	0-5
11225055-1	1999	Compartmentalization of human cytosolic malate dehydrogenase, hcMDH, together with its isozyme partner-mitochondrial form, hmMDH, plays an important role in the aerobic metabolism of the malate-aspartate shuttle and the citric acid cycle.	Citric Acid	220-231	malate dehydrogenase 1	Homo sapiens	30-60
9927373-6	1999	The effect produced by a half-submaximum dose of citric acid (5 breaths) was halved by the bradykinin B2 receptor antagonist HOE 140 (0.1 micromol x kg-1, intravenous) and abolished by the tachykinin NK2 receptor antagonist SR 48968 (0.3 micromol x kg-1, intravenous).	Citric Acid	49-60	B2 bradykinin receptor	Cavia porcellus	91-113
9920886-10	1999	In contrast, the influence of pH on NaDC3-mediated transport of citrate is biphasic in which a pH change from 8.0 to 6.	Citric Acid	64-71	solute carrier family 13 member 3	Homo sapiens	36-41
9920886-12	1999	In addition, the potency of citrate to compete with NaDC3-mediated transport of succinate increases 25-fold when pH is changed from 7.5 to 5.5.	Citric Acid	28-35	solute carrier family 13 member 3	Homo sapiens	52-57
9920886-13	1999	These data show that NaDC3 interacts preferentially with the divalent anionic species of citrate.	Citric Acid	89-96	solute carrier family 13 member 3	Homo sapiens	21-26
9927373-7	1999	Bronchoconstriction induced by a submaximum dose of citric acid (10 breaths) was partially reduced by the administration of HOE 140, SR 48968, or the NK1 receptor antagonist CP-99,994 (8 micromol x kg-1, intravenous) alone and completely abolished by the combination of SR 48968 and CP-99,994.	Citric Acid	52-63	substance-P receptor	Cavia porcellus	150-162
10851292-1	1999	Prolactin stimulates citrate accumulation in prostate cells by increasing the expression of mitochondrial aspartate aminotransferase (mAAT).	Citric Acid	21-28	prolactin	Homo sapiens	0-9
10206097-6	1999	This alteration of the Ca2+ control of the steady-state PTH levels contrasted with the maintenance of the PTH secretory response to a sequential citrate and calcium infusion (CiCa clamp), which was normal in two patients evaluated in the morning following surgery.	Citric Acid	145-152	parathyroid hormone	Homo sapiens	106-109
10851292-1	1999	Prolactin stimulates citrate accumulation in prostate cells by increasing the expression of mitochondrial aspartate aminotransferase (mAAT).	Citric Acid	21-28	serine (or cysteine) preptidase inhibitor, clade A, member 1B	Mus musculus	134-138
10627770-1	1998	Luteinizing hormone releasing hormone (LHRH) agonists have been used in conjunction with gonadotrophins, and occasionally with pulsatile LHRH, for ovulation induction in women with clomiphene-citrate-resistant polycystic ovary syndrome (PCOS) and also for superovulation for in vitro fertilization (IVF) and gamete intrafallopian transfer in women with PCOS.	Citric Acid	192-199	gonadotropin releasing hormone 1	Homo sapiens	0-37
10608615-11	1999	Finally, in order to eliminate the class I molecules from the cell surface, we treated the MT-2 using a buffered citric acid solution (pH 3.8).	Citric Acid	113-124	metallothionein 2A	Homo sapiens	91-95
10627770-1	1998	Luteinizing hormone releasing hormone (LHRH) agonists have been used in conjunction with gonadotrophins, and occasionally with pulsatile LHRH, for ovulation induction in women with clomiphene-citrate-resistant polycystic ovary syndrome (PCOS) and also for superovulation for in vitro fertilization (IVF) and gamete intrafallopian transfer in women with PCOS.	Citric Acid	192-199	gonadotropin releasing hormone 1	Homo sapiens	39-43
9844143-11	1998	This is due, at least in part, to increases in cytosolic citrate metabolism through ATP citrate lyase in rats similar to that seen with chronic metabolic acidosis and hypokalemia.	Citric Acid	57-64	ATP citrate lyase	Rattus norvegicus	84-101
9881153-1	1998	NAD-dependent isocitrate dehydrogenase (IDH) is a key enzyme controlling the activity of the citric acid cycle.	Citric Acid	93-104	isocitrate dehydrogenase [NADP]	Nicotiana tabacum	40-43
9817380-13	1998	Activities of the citric acid cycle enzymes citrate synthase and malate dehydrogenase recovered and were similar to control levels four weeks after relief of the obstruction.	Citric Acid	18-29	citrate synthase, mitochondrial	Oryctolagus cuniculus	44-60
9778326-9	1998	CONCLUSIONS: GP IIb/IIIa antagonist potency is variably enhanced by citrate.	Citric Acid	68-75	integrin subunit alpha 2b	Homo sapiens	13-19
9788754-2	1998	A 400 mg dose of Al in the presence of citric acid inhibited cytosolic total and CN -sensitive superoxide dismutase activities of the cerebral hemisphere in 7- and 30-day treated chicks, whereas in 15-day treated chicks the enzyme activities were decreased in response to both doses in the presence of citric acid.	Citric Acid	39-50	superoxide dismutase 1	Homo sapiens	95-115
9788743-5	1998	This stimulatory effect of citrate was totally abolished when these cells were grown in presence of 1 mM phenyl thiourea, a specific inhibitor of tyrosinase activity.	Citric Acid	27-34	tyrosinase	Mus musculus	146-156
9788754-4	1998	Cerebral catalase activity decreased in response to 400 mg Al when the chicks were also fed with citric acid for 7 and 30 days, but in 15-day treated chicks the enzyme activity was depleted following treatment with 200 and 400 mg Al combined with citric acid.	Citric Acid	97-108	catalase	Homo sapiens	9-17
9788743-14	1998	Citrate, a natural metabolite, is a unique molecule which may be involved in the regulation of melanin biosynthetic pathway, since it enhances melanogenesis by increasing the hydroxylase activity of tyrosinase which is the regulatory enzyme of this pathway.	Citric Acid	0-7	tyrosinase	Mus musculus	199-209
9788754-4	1998	Cerebral catalase activity decreased in response to 400 mg Al when the chicks were also fed with citric acid for 7 and 30 days, but in 15-day treated chicks the enzyme activity was depleted following treatment with 200 and 400 mg Al combined with citric acid.	Citric Acid	247-258	catalase	Homo sapiens	9-17
9788754-5	1998	400 mg Al treatment for 7 days in combination with citric acid inhibited hepatic catalase activity and extension of the treatment period to 15 and 30 days also produced reduction in its activity even in response to the lower Al dose mixed with citric acid.	Citric Acid	51-62	catalase	Homo sapiens	81-89
9730972-1	1998	AMP deaminase (AMPD) plays a central role in preserving the adenylate energy charge in myocytes following exercise and in producing intermediates for the citric acid cycle in muscle.	Citric Acid	154-165	adenosine monophosphate deaminase 1	Homo sapiens	0-13
9722566-5	1998	The carboxyl-terminal half of Aralar (amino acids 321-678) has high similarity with the oxoglutarate, citrate, and adenine nucleotide carriers (28-29% identity), whereas the amino-terminal half (amino acids 1-320) contains three canonical EF-hands.	Citric Acid	102-109	solute carrier family 25 member 12	Homo sapiens	30-36
9730972-1	1998	AMP deaminase (AMPD) plays a central role in preserving the adenylate energy charge in myocytes following exercise and in producing intermediates for the citric acid cycle in muscle.	Citric Acid	154-165	adenosine monophosphate deaminase 1	Homo sapiens	15-19
9846068-6	1998	An increase in the concentration of citrate buffer increased the rate and extent of thermal-induced denaturation of bFGF.	Citric Acid	36-43	fibroblast growth factor 2	Homo sapiens	116-120
9694847-7	1998	When expressed in Xenopus oocytes, SDCT1 mediated electrogenic, sodium-dependent transport of most Krebs cycle intermediates (Km = 20-60 microM), including citrate, succinate, alpha-ketoglutarate, and oxaloacetate.	Citric Acid	156-163	solute carrier family 13 member 2L homeolog	Xenopus laevis	35-40
9772210-7	1998	In cells treated with gallium-citrate/transferrin mixtures, 30 to 35% of the gallium in the cytosol was bound to protein, at least 35 being loosely bound; the main gallium-associated protein was probably intracellular transferrin.	Citric Acid	30-37	transferrin	Homo sapiens	218-229
9691021-4	1998	Substrates of rNaDC-1 evoked inward currents in oocytes expressed with rNaDC-1; succinate, alpha-ketoglutarate, and glutarate were relatively high-affinity substrates, and citrate was a low-affinity substrate of rNaDC-1.	Citric Acid	172-179	solute carrier family 13 member 2	Rattus norvegicus	14-21
9668069-5	1998	Currents were induced in NaDC-1 by a range of di- and tricarboxylates, including citrate, methylsuccinate, fumarate, and tricarballylate.	Citric Acid	81-88	solute carrier family 13 member 2L homeolog	Xenopus laevis	25-31
9688635-7	1998	Importantly, IGFBP-3/Glu-Pg complexes were detected in both human citrate plasma and serum, indicating that these complexes exist in vivo.	Citric Acid	66-73	insulin like growth factor binding protein 3	Homo sapiens	13-20
18967265-4	1998	With 30 s of electrolysis time, a linear calibration curve is obtained over the 0-50 muM range in 0.05 M citrate buffer solution, pH 4.0, with slope (muA/muM) and correlation coefficient of 0.34 and 0.9984, respectively.	Citric Acid	105-112	latexin	Homo sapiens	85-88
9689066-6	1998	ZPI is a 72,000-Mr single-chain protein with an N-terminal amino acid sequence of LAPSPQSPEXXA (X = indeterminate) and an estimated concentration in citrate-treated plasma of 1.0-1.6 microg/ml.	Citric Acid	149-156	serpin family A member 10	Homo sapiens	0-3
9689946-1	1998	In a previous paper we suggested that the methylglyoxalase pathway might have been an anaplerotic route for the archaic reductive citric acid cycle of surface metabolists at the early stage of evolution.	Citric Acid	130-141	glyoxalase I	Homo sapiens	42-58
9681723-3	1998	METHODS: The effect of citrate anticoagulation on the expression of CD11b, CD11c and CD45 on the surface of granulocytes and CD14 on monocytes during haemodialysis with cuprophane membranes, was evaluated by flow cytometric analysis.	Citric Acid	23-30	integrin subunit alpha M	Homo sapiens	68-73
9639597-0	1998	Functional citric acid cycle in an arcA mutant of Escherichia coli during growth with nitrate under anoxic conditions.	Citric Acid	11-22	arginine deiminase	Escherichia coli	35-39
9681723-3	1998	METHODS: The effect of citrate anticoagulation on the expression of CD11b, CD11c and CD45 on the surface of granulocytes and CD14 on monocytes during haemodialysis with cuprophane membranes, was evaluated by flow cytometric analysis.	Citric Acid	23-30	integrin subunit alpha X	Homo sapiens	75-80
9681723-3	1998	METHODS: The effect of citrate anticoagulation on the expression of CD11b, CD11c and CD45 on the surface of granulocytes and CD14 on monocytes during haemodialysis with cuprophane membranes, was evaluated by flow cytometric analysis.	Citric Acid	23-30	protein tyrosine phosphatase receptor type C	Homo sapiens	85-89
9575949-10	1998	Pyruvate dehydrogenase activity in the a form (PDHa) was lower during Int (1.61 +/- 0.17 vs. 2.22 +/- 0.24 mmol.min-1.kg wet muscle-1), and muscle citrate was higher (0.59 +/- 0.04 vs. 0.48 +/- 0.04 mmol/kg dm).	Citric Acid	147-154	pyruvate dehydrogenase E1 subunit alpha 1	Homo sapiens	47-51
9553712-2	1998	To develop an assay for measurement of plasma MPO in horses during the above-mentioned infectious and inflammatory conditions, MPO was purified from equine PMN isolated from blood anticoagulated with citrate.	Citric Acid	200-207	myeloperoxidase	Equus caballus	127-130
9578471-11	1998	Incubations carried out using 55Fe-labelled citrate in the presence of 59Fe-labelled diferric transferrin indicated that citrate-mediated iron binding by the cells decreased with increasing diferric transferrin concentrations but the citrate iron was not replaced by iron from transferrin during the 15-min incubation period.	Citric Acid	121-128	transferrin	Rattus norvegicus	94-105
9578471-4	1998	The endogenous low-molecular-mass iron chelator, citrate, is considered to be a major contributing molecule to non-transferrin iron transport.	Citric Acid	49-56	transferrin	Rattus norvegicus	115-126
9578471-5	1998	This study was conducted to investigate the effects of transferrin on the uptake of citrate and iron citrate by hepatocytes in culture.	Citric Acid	84-91	transferrin	Rattus norvegicus	55-66
9578471-7	1998	Binding and internalisation of both citrate and iron were inhibited in a dose-dependent manner with increasing concentration of diferric transferrin, with iron uptake decreasing to less than 5% of control values.	Citric Acid	36-43	transferrin	Rattus norvegicus	137-148
9578471-11	1998	Incubations carried out using 55Fe-labelled citrate in the presence of 59Fe-labelled diferric transferrin indicated that citrate-mediated iron binding by the cells decreased with increasing diferric transferrin concentrations but the citrate iron was not replaced by iron from transferrin during the 15-min incubation period.	Citric Acid	121-128	transferrin	Rattus norvegicus	94-105
9578471-11	1998	Incubations carried out using 55Fe-labelled citrate in the presence of 59Fe-labelled diferric transferrin indicated that citrate-mediated iron binding by the cells decreased with increasing diferric transferrin concentrations but the citrate iron was not replaced by iron from transferrin during the 15-min incubation period.	Citric Acid	121-128	transferrin	Rattus norvegicus	199-210
9578471-11	1998	Incubations carried out using 55Fe-labelled citrate in the presence of 59Fe-labelled diferric transferrin indicated that citrate-mediated iron binding by the cells decreased with increasing diferric transferrin concentrations but the citrate iron was not replaced by iron from transferrin during the 15-min incubation period.	Citric Acid	121-128	transferrin	Rattus norvegicus	199-210
9578471-11	1998	Incubations carried out using 55Fe-labelled citrate in the presence of 59Fe-labelled diferric transferrin indicated that citrate-mediated iron binding by the cells decreased with increasing diferric transferrin concentrations but the citrate iron was not replaced by iron from transferrin during the 15-min incubation period.	Citric Acid	121-128	transferrin	Rattus norvegicus	199-210
9578471-11	1998	Incubations carried out using 55Fe-labelled citrate in the presence of 59Fe-labelled diferric transferrin indicated that citrate-mediated iron binding by the cells decreased with increasing diferric transferrin concentrations but the citrate iron was not replaced by iron from transferrin during the 15-min incubation period.	Citric Acid	121-128	transferrin	Rattus norvegicus	199-210
9578471-13	1998	These data suggest that citrate-mediated iron uptake by hepatocytes shares at least one common pathway with transferrin-mediated iron uptake.	Citric Acid	24-31	transferrin	Rattus norvegicus	108-119
9518625-1	1998	A substrate cycle between citric acid cycle (CAC) intermediates isocitrate and 2-oxoglutarate, involving NAD+- and NADP+-linked isocitrate dehydrogenase (NAD-IDH and NADP-IDH, respectively) and mitochondrial transhydrogenase (H+-Thase), has recently been proposed.	Citric Acid	26-37	isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma	Rattus norvegicus	158-161
9518625-1	1998	A substrate cycle between citric acid cycle (CAC) intermediates isocitrate and 2-oxoglutarate, involving NAD+- and NADP+-linked isocitrate dehydrogenase (NAD-IDH and NADP-IDH, respectively) and mitochondrial transhydrogenase (H+-Thase), has recently been proposed.	Citric Acid	26-37	isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma	Rattus norvegicus	171-174
9629674-4	1998	Moreover, addition of citrate, a potent ligand for trivalent cations, resulted in a significant withdrawal in mAb recognition of aluminium which was previously bound to either CaM or S100b proteins.	Citric Acid	22-29	S100 protein, beta polypeptide, neural	Mus musculus	183-188
9688217-0	1998	Iron binding and autoreduction by citrate: are these involved in signalling by iron regulatory protein-1?	Citric Acid	34-41	aconitase 1	Homo sapiens	79-104
9521487-13	1998	8-Br-cyclic GMP and the exogenous NO donor linsidomine inhibited aggregation in PRP anticoagulated with citrate or r-hirudin.	Citric Acid	104-111	5'-nucleotidase, cytosolic II	Homo sapiens	12-15
9386152-4	1997	Although minimal activation was seen without ADP, the fraction of platelets expressing P-selectin in response to ADP was greatest in blood anticoagulated with citrate compared with CTI and all other anticoagulants.	Citric Acid	159-166	selectin P	Homo sapiens	87-97
9530999-5	1998	Cultures were exposed to aluminium, glutamate, aluminium/glutamate, aluminium/citric acid and citric acid (since aluminium is thought to enter cells via the transferrin receptor by complexing with citric acid) from 7-12 days in vitro.	Citric Acid	94-105	transferrin	Rattus norvegicus	157-168
9530999-5	1998	Cultures were exposed to aluminium, glutamate, aluminium/glutamate, aluminium/citric acid and citric acid (since aluminium is thought to enter cells via the transferrin receptor by complexing with citric acid) from 7-12 days in vitro.	Citric Acid	94-105	transferrin	Rattus norvegicus	157-168
9375662-5	1997	Increasing extracellular pyruvate from 0 to 5 mM increased pyruvate carboxylase flux as observed by increases in the 14C incorporated into pyruvate and citric acid cycle intermediates, but incorporation into glutamate and glutamine, although relatively high at low pyruvate levels, did not increase as pyruvate carboxylase flux increased.	Citric Acid	152-163	pyruvate carboxylase	Rattus norvegicus	59-79
18642242-7	1997	Whatever the citrate content, precipitation curves for bovine serum albumin (BSA) and alpha-LA intersect at a temperature around 45 degrees C. For a temperature of heat treatment lower than 40 degrees C, a selective enrichment in alpha-LA of the precipitated phase is observed.	Citric Acid	13-20	lactalbumin alpha	Homo sapiens	230-238
18642242-8	1997	As addition of citrate leads to high alpha-LA precipitated fractions at a temperature around 35 degrees C, the precipitation step may be performed at this temperature.	Citric Acid	15-22	lactalbumin alpha	Homo sapiens	37-45
9387145-1	1997	Citrate synthase which condenses acetyl-CoA and oxaloacetate to citrate was purified from Drosophila melanogaster.	Citric Acid	64-71	knockdown	Drosophila melanogaster	0-16
9467872-10	1997	Mitochondrial phosphoenolpyruvate carboxykinase in enterocytes in vivo could convert glycolysis-derived phosphoenolpyruvate to oxaloacetate that, with acetyl CoA, could form citrate for export to support cytosolic lipogenesis as an activator of acetyl CoA carboxylase, a source of carbon via ATP:citrate lyase and of NADPH via NADP:malate dehydrogenase or NADP:isocitrate dehydrogenase.	Citric Acid	174-181	phosphoenolpyruvate carboxykinase [GTP], mitochondrial	Oryctolagus cuniculus	0-47
9315536-0	1997	Effect of Ca2+ on GP IIb-IIIa interactions with integrilin: enhanced GP IIb-IIIa binding and inhibition of platelet aggregation by reductions in the concentration of ionized calcium in plasma anticoagulated with citrate.	Citric Acid	212-219	integrin subunit alpha 2b	Homo sapiens	18-24
9326580-4	1997	Utilizing an immunochemical probe for oxidatively modified proteins, we show that mitochondrial aconitase, an enzyme in the citric acid cycle, is a specific target during aging of the housefly.	Citric Acid	124-135	aconitase 2	Homo sapiens	82-105
9342380-8	1997	ODR-10 expressed in human cells also responds to two anionic compounds, pyruvate and citrate, which are metabolic precursors used for diacetyl production by certain bacterial species.	Citric Acid	85-92	Serpentine receptor class r-10	Caenorhabditis elegans	0-6
9315536-2	1997	The present study was designed to determine whether the reduced Ca2+ concentrations in plasma anticoagulated with citrate affect Integrilin binding to GP IIb-IIIa and the ex vivo pharmacodynamic measurements for this drug.	Citric Acid	114-121	integrin subunit alpha 2b	Homo sapiens	151-157
9315536-6	1997	Citrate anticoagulation decreased the amounts of Integrilin required to inhibit the binding of PAC1, a monoclonal antibody that mimics the GP IIb-IIIa binding activity of fibrinogen.	Citric Acid	0-7	dual specificity phosphatase 2	Homo sapiens	95-99
9381947-5	1997	The trained SCI groups had significantly higher levels of the citric acid cycle marker enzyme citrate synthase (34% and 63%) than the untrained SCI groups and able-bodied subjects, respectively.	Citric Acid	62-73	citrate synthase	Homo sapiens	94-110
9315536-6	1997	Citrate anticoagulation decreased the amounts of Integrilin required to inhibit the binding of PAC1, a monoclonal antibody that mimics the GP IIb-IIIa binding activity of fibrinogen.	Citric Acid	0-7	integrin subunit alpha 2b	Homo sapiens	139-145
9315536-8	1997	CONCLUSIONS: These data suggest that citrate anticoagulation removes Ca2+ from GP IIb-IIIa and enhances the apparent inhibitory activity of Integrilin.	Citric Acid	37-44	integrin subunit alpha 2b	Homo sapiens	79-85
9339389-3	1997	MATERIAL AND METHODS: TNF alpha was measured by a WEHI 164 bioassay in the plasma of 16 septic patients anticoagulated with heparin, citrate, or EDTA.	Citric Acid	133-140	tumor necrosis factor	Homo sapiens	22-31
9303500-5	1997	Iron citrate inhibited the uptake of 59Fe-transferrin (2.5 micromol/L Fe) in a concentration-dependent manner with a maximum effect when the citrate-iron:Tf-Fe molar ratio was 10:1.	Citric Acid	5-12	transferrin	Homo sapiens	42-53
9339389-8	1997	RESULTS: No biologically active TNF alpha was detected in the plasma with heparin anticoagulation, whereas with citrate, reproducible, TNF alpha-induced cytotoxicity was detectable in blood samples of 13 of the 16 patients.	Citric Acid	112-119	tumor necrosis factor	Homo sapiens	135-144
9299784-6	1997	The overexpression of MDH2 activity also causes an evaluation in the accumulation of fumaric acid and citric acid.	Citric Acid	102-113	malate dehydrogenase MDH2	Saccharomyces cerevisiae S288C	22-26
9313859-1	1997	Enantiomers of 4-nitrophenyl 4-X-phenacyl methylphosphonate esters (X = H, PMN; CH3; and CH3O) inactivate human alpha-thrombin with rate constants 4-235 M-1 s-1 in pH 6.5, 0.025 M citrate buffer, and 0.15 M NaCl at 7.0 +/- 0.1 degrees C. Stereoselectivity of the inactivation of thrombin is 2-39 and favors the levorotatory enantiomers.	Citric Acid	180-187	coagulation factor II, thrombin	Homo sapiens	118-126
9239450-10	1997	In guinea pig, citric acid induced cough was increased by ACE inhibitors, captopril, alacepril, enalapril and lisinopril (10 and 30 mg/kg p.o.).	Citric Acid	15-26	LOW QUALITY PROTEIN: angiotensin-converting enzyme	Cavia porcellus	58-61
9244391-8	1997	Citrate and isocitrate concentrations were also elevated in the idh2 mutants, but probably not to toxic levels.	Citric Acid	0-7	isocitrate dehydrogenase (NAD(+)) IDH2	Saccharomyces cerevisiae S288C	64-68
9379358-0	1997	Gastroprotective effect of MX1 (a novel salt of the active metabolite of roxatidine with a complex of bismuth and citric acid) against stress ulcers in rats.	Citric Acid	114-125	MX dynamin like GTPase 1	Rattus norvegicus	27-30
9379358-1	1997	We have studied the effect of the newly synthesized agent MX1, a salt of the active metabolite of the H2-blocker roxatidine with a complex of bismuth and citric acid (N-[3-(3-(1-piperidinylmethyl)phenoxy)propyl]-hydroxyacetamide+ ++ -2-hydroxypropane-1,2,3-tricarboxilate-bismuth(3+) complex), against restraint stress ulcers in rats (24 h immobilization).	Citric Acid	154-165	MX dynamin like GTPase 1	Rattus norvegicus	58-61
9277403-5	1997	Oocytes injected with NaDC-2 cRNA exhibit increased transport of succinate, citrate, and glutarate.	Citric Acid	76-83	solute carrier family 13 member 2 S homeolog	Xenopus laevis	22-28
9277403-8	1997	The transport of succinate by NaDC-2 is insensitive to pH, whereas the transport of citrate is inhibited at high pH.	Citric Acid	84-91	solute carrier family 13 member 2 S homeolog	Xenopus laevis	30-36
9249774-9	1997	Citrate abolished the release of MPO almost completely, whereas LF release was partially inhibited.	Citric Acid	0-7	myeloperoxidase	Homo sapiens	33-36
9195881-3	1997	The existence of an anionic binding site near the NADP+ has been determined from the structures of the complexes of AR with citrate, cacodylate and glucose-6-phosphate.	Citric Acid	124-131	aldo-keto reductase family 1 member B	Homo sapiens	116-118
12237366-4	1997	The transcripts for phosphoenolpyruvate carboxylase, cytosolic pyruvate kinase, citrate synthase, and NADP-isocitrate dehydrogenase increased; phosphoenolpyruvate carboxylase activity increased; and malate, citrate, isocitrate, and [alpha]-oxoglutarate accumulated in leaves and roots.	Citric Acid	80-87	phosphoenolpyruvate carboxylase	Nicotiana tabacum	143-174
9057641-1	1997	NNKY5-5, an IgG monoclonal antibody directed against the von Willebrand factor-binding domain of glycoprotein (GP) Ib alpha, induced weak but irreversible aggregation (or association) of platelets in citrate-anticoagulated platelet-rich plasma.	Citric Acid	200-207	glycoprotein Ib platelet subunit alpha	Homo sapiens	97-123
9099897-1	1997	Citrate production is a major physiological function of the prostate that is regulated by testosterone and prolactin.	Citric Acid	0-7	prolactin	Homo sapiens	107-116
9073575-2	1997	More specifically, the activity of two [Fe-S] enzymes was followed during the course of NO synthase expression:mitochondrial aconitase, which catalyzes citrate:isocitrate conversion in the Krebs cycle, and cytoplasmic aconitase, or iron regulatory protein (IRP), a trans-regulator that controls expression at the posttranscriptional level of proteins involved in iron metabolism.	Citric Acid	152-159	aconitase 2	Homo sapiens	111-134
9325434-6	1997	In fact, recent studies have demonstrated that the membrane-bound Tf homologue, MTf, can bind and internalize Fe from 59Fe-citrate.	Citric Acid	123-130	metallothionein 1L, pseudogene	Homo sapiens	80-83
9161883-2	1997	Specific reduction in class I MHC levels (range 60-76%) was induced by brief exposure to citrate buffer (pH 3.0).	Citric Acid	89-96	major histocompatibility complex, class I, C	Homo sapiens	30-33
9029219-7	1997	The activation constant (Ka) for citrate activation was increased to the same extent by AMPK phosphorylation, regardless of previous or subsequent phosphorylation by PKA.	Citric Acid	33-40	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	88-92
9028637-1	1997	Inhibition of AADC for several hours increases the activity and mass of NaKATPase in proximal tubular basolateral membranes and reduces phosphate (P1) and citrate excretion, but has only a small effect on Na excretion.	Citric Acid	155-162	dopa decarboxylase	Rattus norvegicus	14-18
9018332-12	1997	The results support the concept that mitochondrial zinc is an inhibitor of m-aconitase and citrate oxidation; and that prolactin and testosterone regulation of mitochondrial zinc provides a mechanism for their regulation of citrate oxidation in citrate-producing prostate epithelial cells.	Citric Acid	224-231	prolactin	Rattus norvegicus	119-128
9297604-3	1997	Comparison of kallikrein-like activity on glass using citrate or heparinized plasma demonstrated enhanced activity in the presence of heparin.	Citric Acid	54-61	kallikrein related peptidase 4	Homo sapiens	14-24
9018332-12	1997	The results support the concept that mitochondrial zinc is an inhibitor of m-aconitase and citrate oxidation; and that prolactin and testosterone regulation of mitochondrial zinc provides a mechanism for their regulation of citrate oxidation in citrate-producing prostate epithelial cells.	Citric Acid	224-231	prolactin	Rattus norvegicus	119-128
9037708-1	1997	Citrate synthase forms citrate by deprotonation of acetyl-CoA followed by nucleophilic attack of this substrate on oxaloacetate, and subsequent hydrolysis.	Citric Acid	23-30	citrate synthase	Homo sapiens	0-16
8994263-4	1997	The finding of an IRE in the citric acid cycle enzymes, mitochondrial aconitase and succinate dehydrogenase, suggests that the IRPs may also influence cellular energy production.	Citric Acid	29-40	aconitase 2	Homo sapiens	56-79
10168560-3	1996	Blood flow was reduced to 30-50 mL min-1 depending on the children"s size and weight to prevent citrate reactions.	Citric Acid	96-103	CD59 molecule (CD59 blood group)	Homo sapiens	35-40
8946005-1	1996	The rabbit and human Na(+)-dicarboxylate cotransporters, NaDC-1 and hNaDC-1, were expressed in Xenopus oocytes, and the transport of succinate, citrate, and glutarate was compared.	Citric Acid	144-151	solute carrier family 13 member 2	Homo sapiens	68-75
8941657-2	1996	The present study addressed the effect of chronic metabolic acidosis on a cytosolic enzyme of citrate metabolism, ATP citrate lyase.	Citric Acid	94-101	ATP citrate lyase	Rattus norvegicus	114-131
8946005-4	1996	At pH 7.5, the K(m) value for citrate was 0.9 mM in the rabbit NaDC-1 and 7 mM in the human hNaDC-1.	Citric Acid	30-37	solute carrier family 13 member 2	Oryctolagus cuniculus	63-69
8946005-4	1996	At pH 7.5, the K(m) value for citrate was 0.9 mM in the rabbit NaDC-1 and 7 mM in the human hNaDC-1.	Citric Acid	30-37	solute carrier family 13 member 2	Homo sapiens	92-99
8946005-6	1996	At pH 5.5, the K(m) value for citrate decreased to 1.2 mM in hNaDC-1 and decreased to 0.3 mM in the rabbit transporter.	Citric Acid	30-37	solute carrier family 13 member 2	Homo sapiens	61-68
8865808-1	1996	The tricarboxylate or citrate transporter protein (CTP) catalyzes the transport of citrate across the inner mitochondrial membrane by an exchange for malate or some other anionic metabolite.	Citric Acid	22-29	solute carrier family 25 member 1	Bos taurus	51-54
8957982-1	1996	We have investigated the effect on the pH of the gastric fluid of a single dose of sodium citrate 0.3 mol litre-1 (antacid) and a solution containing sodium citrate dehydrate (100 mg ml-1) with citric acid monohydrate (66 mg ml-1) (buffer).	Citric Acid	194-217	interleukin 17F	Homo sapiens	183-187
9415099-1	1996	The role of the citric acid cycle enzyme NADP-dependent isocitrate dehydrogenase (IDH-NADP) and its allele product variants in resisting the oxidative agent paraquat, was analyzed among descendants of reciprocal crosses between fast developmental time short-lived individuals (F-) and slow developmental time long-lived ones (S+), in Drosophila melanogaster.	Citric Acid	16-27	Isocitrate dehydrogenase	Drosophila melanogaster	82-90
8865808-5	1996	The amino acid sequence of the mature bovine CTP is 95.6, 94.9, 32.2% identical to that of the citrate carrier from man, rat and yeast, respectively.	Citric Acid	95-102	solute carrier family 25 member 1	Bos taurus	45-48
8816895-9	1996	p53 immunoperoxidase staining using citrate buffer/microwave antigen retrieval was performed.	Citric Acid	36-43	tumor protein p53	Homo sapiens	0-3
8798666-9	1996	Thus, expression of the iron-sulfur protein mitochondrial aconitase and function of the citric acid cycle may be regulated by iron levels in cells.	Citric Acid	88-99	aconitase 2	Homo sapiens	44-67
8840462-5	1996	The increased expression of GMP-140 was paralleled by the enhanced platelet clumping in the samples anticoagulated with either EDTAK2 or heparin, and the raised platelet microparticles in blood withdrawn into citrate.	Citric Acid	209-216	selectin P	Homo sapiens	28-35
8774722-1	1996	A mathematical model of the citric acid cycle devoted to the analysis of 13C-NMR data was developed for determining the relative flux of molecules through the anaplerotic versus oxidative pathways and the relative pyruvate carboxylase versus pyruvate dehydrogenase activities.	Citric Acid	28-39	pyruvate carboxylase	Homo sapiens	214-234
8696078-0	1996	On the mechanism of citrate inhibition of ceruloplasmin ferroxidase activity.	Citric Acid	20-27	ceruloplasmin	Homo sapiens	42-67
8836557-7	1996	Fluorocitrate, a suicidal-inhibitor of aconitase, also protected astrocytes, but not neurons, from hypoxia in "pure" culture, presumably by increasing intracellular citrate concentrations through inhibition of the catalysis of citrate to isocitrate We conclude that FBP and citrate attenuate hypoxic neuronal injury through their effects on astrocytes.	Citric Acid	6-13	fructose-bisphosphatase 1	Homo sapiens	266-269
8661307-0	1996	Effect of Cation Binding on the Proton Chemical Shifts and the Spin-Spin Coupling Constant of Citrate	Citric Acid	94-101	spindlin 1	Homo sapiens	63-67
9035730-1	1996	Coinjection of citrate iron complex (7.5-10 mg iron/kg) with Escherichia coli lipopolysaccharide (LPS) inhibited generation of nitric oxide in the liver of mice caused by LPS-dependent synthesis of inducible NO-synthase (iNOS).	Citric Acid	15-22	nitric oxide synthase 2, inducible	Mus musculus	198-219
9035730-1	1996	Coinjection of citrate iron complex (7.5-10 mg iron/kg) with Escherichia coli lipopolysaccharide (LPS) inhibited generation of nitric oxide in the liver of mice caused by LPS-dependent synthesis of inducible NO-synthase (iNOS).	Citric Acid	15-22	nitric oxide synthase 2, inducible	Mus musculus	221-225
8661307-0	1996	Effect of Cation Binding on the Proton Chemical Shifts and the Spin-Spin Coupling Constant of Citrate	Citric Acid	94-101	spindlin 1	Homo sapiens	68-72
8682202-2	1996	More recently, IRP-1 was found to represent the functional cytoplasmic homologue of mitochondrial aconitase, a citric acid cycle enzyme.	Citric Acid	111-122	aconitase 1	Homo sapiens	15-20
8682202-2	1996	More recently, IRP-1 was found to represent the functional cytoplasmic homologue of mitochondrial aconitase, a citric acid cycle enzyme.	Citric Acid	111-122	aconitase 2	Homo sapiens	84-107
12226312-2	1996	We found that an increase in the tricarboxylic acid cycle intermediate citrate (either after its exogenous supply to cells or after inhibition of aconitase by monofluoroacetate) caused a rapid and dramatic increase in the steady-state level of Aox1 mRNA and AOX protein.	Citric Acid	71-78	ubiquinol oxidase 1, mitochondrial	Nicotiana tabacum	244-248
12226312-2	1996	We found that an increase in the tricarboxylic acid cycle intermediate citrate (either after its exogenous supply to cells or after inhibition of aconitase by monofluoroacetate) caused a rapid and dramatic increase in the steady-state level of Aox1 mRNA and AOX protein.	Citric Acid	71-78	ubiquinol oxidase 1, mitochondrial	Nicotiana tabacum	258-261
12226312-4	1996	The results indicate that citrate may be an important signal metabolite regulating Aox1 gene expression.	Citric Acid	26-33	ubiquinol oxidase 1, mitochondrial	Nicotiana tabacum	83-87
8807546-2	1996	Ion chromatography with gradient elution was preferred to an enzymatic-spectrophotometric method for citrate concentrations in the range 0.4-11 mg l-1.	Citric Acid	101-108	immunoglobulin kappa variable 1-16	Homo sapiens	147-150
8795046-4	1996	On the other hand, the melting temperatures of lysozyme with or without additives in 0.02 M citrate buffer (pH 6.0) were evaluated using differential scanning calorimetry.	Citric Acid	92-99	lysozyme	Homo sapiens	47-55
8630592-8	1996	In conclusion, these results show that inhaled citric acid can induce the development of an airway hyperresponsiveness in the guinea pig through a release of tachykinins, and also demonstrate that NK2-receptor stimulation plays a predominant role in the development of airway hyperresponsiveness.	Citric Acid	47-58	substance-K receptor	Cavia porcellus	197-209
8607193-6	1996	There was an inverse correlation between Me2+ and citrate for all patients.	Citric Acid	50-57	malic enzyme 2	Homo sapiens	41-44
8609829-0	1996	Prolactin specifically regulates citrate oxidation and m-aconitase of rat prostate epithelial cells.	Citric Acid	33-40	prolactin	Rattus norvegicus	0-9
8609829-4	1996	Recent studies have revealed that prolactin (PRL) stimulates net citrate production of rat lateral prostate (RLP).	Citric Acid	65-72	prolactin	Rattus norvegicus	34-43
8609829-4	1996	Recent studies have revealed that prolactin (PRL) stimulates net citrate production of rat lateral prostate (RLP).	Citric Acid	65-72	prolactin	Rattus norvegicus	45-48
8609829-6	1996	The current studies were concerned with the possibility that PRL might be involved in the regulation of citrate oxidation and m-aconitase of prostate cells.	Citric Acid	104-111	prolactin	Rattus norvegicus	61-64
8609829-8	1996	The results showed that PRL in vitro and in vivo decreased citrate utilization and the level of m-aconitase in RLP cells, and conversely increased citrate utilization and m-aconitase in RVP cells.	Citric Acid	59-66	prolactin	Rattus norvegicus	24-27
8609829-8	1996	The results showed that PRL in vitro and in vivo decreased citrate utilization and the level of m-aconitase in RLP cells, and conversely increased citrate utilization and m-aconitase in RVP cells.	Citric Acid	147-154	prolactin	Rattus norvegicus	24-27
8609829-10	1996	The effects of PRL on both citrate utilization and m-aconitase of RLP and RVP were abolished by cycloheximide and actinomycin.	Citric Acid	27-34	prolactin	Rattus norvegicus	15-18
8609829-11	1996	Mitochondrial studies revealed that PRL decreased citrate oxidation of RLP and increased citrate oxidation of RVP, but had no effect on isocitrate oxidation.	Citric Acid	50-57	prolactin	Rattus norvegicus	36-39
8609829-11	1996	Mitochondrial studies revealed that PRL decreased citrate oxidation of RLP and increased citrate oxidation of RVP, but had no effect on isocitrate oxidation.	Citric Acid	89-96	prolactin	Rattus norvegicus	36-39
8609829-12	1996	In conclusion, these studies establish that PRL has a physiological role in the regulation of citrate oxidation in prostate, and that this action is associated with PRL regulation of the biosynthesis of m-aconitase.	Citric Acid	94-101	prolactin	Rattus norvegicus	44-47
8607193-7	1996	Me2+, like ionized calcium (Ca2+), is chelated by citrate and its evolution is a mirror image of that of citrate.	Citric Acid	50-57	malic enzyme 2	Homo sapiens	0-3
8607193-7	1996	Me2+, like ionized calcium (Ca2+), is chelated by citrate and its evolution is a mirror image of that of citrate.	Citric Acid	105-112	malic enzyme 2	Homo sapiens	0-3
8667073-2	1996	METHODS: In vivo testicular uptake and retention of the transferrin binding radionuclides 114mIn-citrate and 59Fe-citrate were compared with that of the nontransferrin binding isotopes 137Cs-citrate and Na125I for 63 days postinjection.	Citric Acid	97-104	transferrin	Homo sapiens	56-67
8737057-1	1996	MX1 (N-[3-(3-(1-piperidinylmethyl)phenoxy)propyl]-hydroxyacetamide+ ++ 2-hydroxypropane-1,2,3-tricarboxylate bismuth (3+) complex) is a novel salt of the active metabolite of H2-antagonist roxatidine with a complex of bismuth with citric acid.	Citric Acid	231-242	MX dynamin like GTPase 1	Rattus norvegicus	0-3
8785392-7	1996	During hemodialysis with CUP, anticoagulation with citrate significantly reduced neutropenia, C3a levels, and lactoferrin release.	Citric Acid	51-58	complement C3	Homo sapiens	94-97
8594304-7	1996	Since adenomyosis was induced by chronic hyperprolactinemia, the change of citrate level in the uterus with this lesion might imply some effects of prolactin (PRL) on metabolism and/or secretion of citrate.	Citric Acid	75-82	prolactin	Mus musculus	159-162
8791263-4	1996	The selective tissue kallikrein inhibitor CH694 inhibited cough caused by citric acid but not by bradykinin.	Citric Acid	74-85	serine peptidase inhibitor Kazal type 6	Homo sapiens	21-41
8530520-10	1995	Furthermore, Drosophila SDHb represents the second example, after porcine mitochondrial aconitase, of an enzyme of the citric acid cycle whose mRNA possesses all necessary features for translational regulation by cellular iron levels.	Citric Acid	119-130	Succinate dehydrogenase, subunit B (iron-sulfur)	Drosophila melanogaster	24-28
8837351-1	1996	We evaluated a new glucose-free citrate-acetate-NaCl platelet additive solution (PAS 2).	Citric Acid	32-39	glycophorin C (Gerbich blood group)	Homo sapiens	81-86
8873419-1	1996	Drawing of blood into a citrate-phosphate-dextrose (CPD) solution with a reduced citrate concentration has been shown to improve the maintenance of coagulation factor VIII (F VIII) in plasma and to give possibilities to improve erythrocyte preservation.	Citric Acid	24-31	coagulation factor VIII	Homo sapiens	173-179
8713780-4	1996	The amount of circulating APC is calculated from the difference between the total amount of complexed APC (sample in citrate plus heparin) and the amount of APC complexed in vivo (sample in citrate plus inhibitor).	Citric Acid	117-124	APC regulator of WNT signaling pathway	Homo sapiens	26-29
8713780-4	1996	The amount of circulating APC is calculated from the difference between the total amount of complexed APC (sample in citrate plus heparin) and the amount of APC complexed in vivo (sample in citrate plus inhibitor).	Citric Acid	190-197	APC regulator of WNT signaling pathway	Homo sapiens	26-29
7673129-6	1995	Binding of partially purified yeast-expressed AE1 to 4-acetamido-4"-isothiocyanostilbene-2,2"-disulfonate resin was competitive with the transportable substrate chloride but not the nontransported anion citrate, suggesting that the structure of the anion binding site is preserved.	Citric Acid	203-210	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	46-49
8847993-0	1995	Effect of D- and L-1,3-butanediol isomers on glycolytic and citric acid cycle intermediates in the rat brain.	Citric Acid	60-71	ribosomal protein L4	Rattus norvegicus	10-20
8595612-8	1995	RESULTS: The medians of up-regulation of CD11b were 540.2 (range 235.2-653.3) for heparin vs. 186.5 (55.7-207.1) for EDTA and 192.5 (69.2-263.8) for citrate mixture, P < 0.01.	Citric Acid	149-156	integrin subunit alpha M	Homo sapiens	41-46
8595612-9	1995	The medians of down-regulation of L-selectin were 79 (32-192) for heparin vs. 18.4 (0-188) for EDTA and 36.2 (7.4-135) for citrate mixture, P < 0.05.	Citric Acid	123-130	selectin L	Homo sapiens	34-44
8586125-9	1995	Aerosolized fenspiride (1, 3 and 10 mg.mL-1) administered for 4 min reduced citric acid (300 mM) induced cough, but 0.1 mg.mL-1 was without effect.	Citric Acid	76-87	L1 cell adhesion molecule	Mus musculus	39-43
8586125-10	1995	Pretreatment with aerosolized fenspiride (10 mg.mL-1) caused a shift in the citric acid dose response curve to the right.	Citric Acid	76-87	L1 cell adhesion molecule	Mus musculus	48-52
7665595-8	1995	This histidine can also be phosphorylated by ATP, and its phosphorylation is the first step in the conversion of citrate and CoA to oxaloacetate and acetyl-CoA by ATP-citrate lyase.	Citric Acid	113-120	ATP citrate lyase	Rattus norvegicus	163-180
7580053-5	1995	Citrate and urate inhibit the iron-ceruloplasmin-dependent ascorbate oxidation by chelating ferric ions.	Citric Acid	0-7	ceruloplasmin	Homo sapiens	35-48
7669921-2	1995	CD spectroscopic studies on two synthetic fragments of the human neurofilament protein midsized subunit (NF-M), and their alanine-for-serine-substituted and/or serine-phosphorylated derivatives showed the formation of stable, citric acid resistant complexes of Al3+ with peptide ligands [M. Hollosi, Z. M. Shen, A. Perczel, and G. D. Fasman (1994) Proc.	Citric Acid	226-237	neurofilament medium chain	Homo sapiens	65-103
7669921-2	1995	CD spectroscopic studies on two synthetic fragments of the human neurofilament protein midsized subunit (NF-M), and their alanine-for-serine-substituted and/or serine-phosphorylated derivatives showed the formation of stable, citric acid resistant complexes of Al3+ with peptide ligands [M. Hollosi, Z. M. Shen, A. Perczel, and G. D. Fasman (1994) Proc.	Citric Acid	226-237	neurofilament medium chain	Homo sapiens	105-109
8846425-7	1995	A role for NK2 receptor stimulation has also been clearly demonstrated in bronchoconstriction induced by various agents known to induce the release of tachykinins (capsaicin, resiniferatoxin, citric acid, sodium metabisulfite diethyl ether, serotonin, and bradykinin), in allergen-induced airway constriction in the guinea pig sensitized to ovalbumin, and in hyperpnea-induced bronchoconstriction.	Citric Acid	192-203	substance-K receptor	Cavia porcellus	11-23
7646445-7	1995	Since ATP citrate-lyase, the cytosolic enzyme that catalyses the conversion of citrate into acetyl-CoA, catalyses an early rate-limiting step in fatty acid synthesis, levels of cytosolic citrate may be rate controlling for de novo fatty acid and sterol synthesis.	Citric Acid	79-86	ATP citrate lyase	Rattus norvegicus	6-23
7619077-9	1995	In recombinant rat muscle PFK-2/FBPase-2, mutation of Arg-104 to Ser increased the Km for Fru-6-P 60-fold, increased the IC50 of citrate, increased the Vmax.	Citric Acid	129-136	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	Rattus norvegicus	26-31
7619077-9	1995	In recombinant rat muscle PFK-2/FBPase-2, mutation of Arg-104 to Ser increased the Km for Fru-6-P 60-fold, increased the IC50 of citrate, increased the Vmax.	Citric Acid	129-136	fructose-bisphosphatase 2	Rattus norvegicus	32-40
7675770-1	1995	Microwave heating of formalin-fixed, paraffin embedded tissue sections in citrate buffer (MHC) has been shown recently to enhance the antigenicity of a number of formalin-sensitive epitopes.	Citric Acid	74-81	major histocompatibility complex, class I, C	Homo sapiens	90-93
7759481-3	1995	Ternary complexes of periodate-modified transferrin and either Fe(III) with nitrilotriacetate (NTA), oxalate, citrate, or EDTA, or of Cu(II) with oxalate could be formed.	Citric Acid	110-117	transferrin	Homo sapiens	40-51
7771027-7	1995	RESULTS: We observed an increased urinary excretion rate of citrate from a mean of 1.9 mmol/24 h prealkali to 2.6 mmol/24 h postalkali (P < 0.0004) and of THP from a mean of 94.0 mg/24 h prealkali to 199.3 mg/24 h postalkali (P < 0.0016).	Citric Acid	60-67	uromodulin	Homo sapiens	158-161
7771027-9	1995	CONCLUSIONS: To our knowledge this is the first report correlating increased urinary citrate with THP excretion rate following oral alkalinization with potassium citrate in calcium stone formers.	Citric Acid	85-92	uromodulin	Homo sapiens	98-101
7730304-17	1995	The following conclusions can be drawn from the calculated reaction rates: (i) about half of the lactate conversion to glucose occurs via the citrate cleavage pathway, (ii) the flux through the reversal of the isocitrate dehydrogenase reaction is almost as fast as that through the citrate synthase reaction, and (iii) the flux through citrate synthase and alpha-ketoglutarate dehydrogenase is 1.6- and 3.2-fold that through pyruvate carboxylase, respectively.	Citric Acid	142-149	citrate synthase	Rattus norvegicus	282-298
7759512-1	1995	Mitochondrial aspartate aminotransferase (mAAT) is one of two key enzymes in the pathway of citrate production in prostate.	Citric Acid	92-99	serine (or cysteine) preptidase inhibitor, clade A, member 1B	Mus musculus	42-46
7663422-3	1995	The polyamines compete with Mg2+ for common binding sites on Mg2+ buffers such as ATP, ADP and citrate, releasing bound Mg2+ and increasing the [Mg2+]free.	Citric Acid	95-102	mucin 7, secreted	Homo sapiens	28-31
7663422-3	1995	The polyamines compete with Mg2+ for common binding sites on Mg2+ buffers such as ATP, ADP and citrate, releasing bound Mg2+ and increasing the [Mg2+]free.	Citric Acid	95-102	mucin 7, secreted	Homo sapiens	61-64
7663422-3	1995	The polyamines compete with Mg2+ for common binding sites on Mg2+ buffers such as ATP, ADP and citrate, releasing bound Mg2+ and increasing the [Mg2+]free.	Citric Acid	95-102	mucin 7, secreted	Homo sapiens	61-64
7663422-3	1995	The polyamines compete with Mg2+ for common binding sites on Mg2+ buffers such as ATP, ADP and citrate, releasing bound Mg2+ and increasing the [Mg2+]free.	Citric Acid	95-102	mucin 7, secreted	Homo sapiens	61-64
7657754-6	1995	However, DAO activity was correlated with citric acid only in the oligoasthenozoospermic and the azoospermic groups.	Citric Acid	42-53	amine oxidase copper containing 1	Homo sapiens	9-12
7676467-0	1995	Arthropod venom citrate inhibits phospholipase A2.	Citric Acid	16-23	phospholipase A2	Apis mellifera	33-49
7676469-9	1995	These anions include citrate, 3-phosphoglycerate and 2-phosphoglycerate, which also inhibit the PLA2 activity of notexin.	Citric Acid	21-28	phospholipase A2 group IB	Homo sapiens	96-100
7730305-5	1995	This fitting yielded rates which we express relative to that of pyruvate carboxylase: citric acid cycle represented by the irreversible alpha-ketoglutarate dehydrogenase = 0.32; citrate synthase = 0.64; reversal of isocitrate dehydrogenase = 0.52; citrate lyase = 0.33, aspartate shuttle = 0.24, and malate shuttle = 0.44.	Citric Acid	86-97	oxoglutarate dehydrogenase	Rattus norvegicus	136-169
7730304-17	1995	The following conclusions can be drawn from the calculated reaction rates: (i) about half of the lactate conversion to glucose occurs via the citrate cleavage pathway, (ii) the flux through the reversal of the isocitrate dehydrogenase reaction is almost as fast as that through the citrate synthase reaction, and (iii) the flux through citrate synthase and alpha-ketoglutarate dehydrogenase is 1.6- and 3.2-fold that through pyruvate carboxylase, respectively.	Citric Acid	142-149	citrate synthase	Rattus norvegicus	336-352
7730304-17	1995	The following conclusions can be drawn from the calculated reaction rates: (i) about half of the lactate conversion to glucose occurs via the citrate cleavage pathway, (ii) the flux through the reversal of the isocitrate dehydrogenase reaction is almost as fast as that through the citrate synthase reaction, and (iii) the flux through citrate synthase and alpha-ketoglutarate dehydrogenase is 1.6- and 3.2-fold that through pyruvate carboxylase, respectively.	Citric Acid	142-149	oxoglutarate dehydrogenase	Rattus norvegicus	357-390
7730304-17	1995	The following conclusions can be drawn from the calculated reaction rates: (i) about half of the lactate conversion to glucose occurs via the citrate cleavage pathway, (ii) the flux through the reversal of the isocitrate dehydrogenase reaction is almost as fast as that through the citrate synthase reaction, and (iii) the flux through citrate synthase and alpha-ketoglutarate dehydrogenase is 1.6- and 3.2-fold that through pyruvate carboxylase, respectively.	Citric Acid	142-149	pyruvate carboxylase	Rattus norvegicus	425-445
7726729-4	1995	With the formalin-fixed tissues, we compared pepsin predigestion with microwave irradiation in citrate buffer as means of enhancing the sensitivity of p53 detection.	Citric Acid	95-102	tumor protein p53	Homo sapiens	151-154
7562952-3	1995	Pyruvate carboxylase plays a pivotal role in gluconeogenesis and in supplying carbon units for the citric acid cycle.	Citric Acid	99-110	pyruvate carboxylase	Mus musculus	0-20
7596346-6	1995	Conversely, citrate levels in IBAT were increased in animals treated with TNF, suggesting that it could be the cause for the increased fatty acid synthesis in this tissue.	Citric Acid	12-19	tumor necrosis factor	Rattus norvegicus	74-77
7716083-4	1995	Two key regulatory enzymes involved in citrate synthesis by prostate epithelial cells are mitochondrial aspartate aminotransferase (mAAT) which provides oxalacetate, and PDH E1 alpha (pyruvate dehydrogenase) which provides acetyl CoA for citrate synthesis.	Citric Acid	39-46	branched chain keto acid dehydrogenase E1 subunit alpha	Rattus norvegicus	174-182
7716083-4	1995	Two key regulatory enzymes involved in citrate synthesis by prostate epithelial cells are mitochondrial aspartate aminotransferase (mAAT) which provides oxalacetate, and PDH E1 alpha (pyruvate dehydrogenase) which provides acetyl CoA for citrate synthesis.	Citric Acid	238-245	branched chain keto acid dehydrogenase E1 subunit alpha	Rattus norvegicus	174-182
7890640-4	1995	We show here that the archetypal serpin, alpha 1-antitrypsin, can also be induced to adopt the latent conformation by heating at high temperatures in 0.7 M citrate for 12 h. The resulting species elutes at a lower sodium chloride concentration on an anion-exchange column and has a more cathodal electrophoretic mobility on non-denaturing polyacrylamide gel electrophoresis and isoelectric focusing than native M antitrypsin.	Citric Acid	156-163	serpin family A member 1	Bos taurus	41-60
7536352-3	1995	Those samples with HbS or HbC were verified by means of agar-citrate electrophoresis at pH 6.2.	Citric Acid	61-68	keratin 88, pseudogene	Homo sapiens	26-29
7665190-12	1995	When the reaction mixtures were incubated with the urea-activated gamma-glutamyl hydrolase, a maximum stimulatory effect on the enzyme activity was observed with the bivalent metal ion Ca2+ whereas the most potent inhibitory effect was observed with the trivalent anion citrate.	Citric Acid	270-277	gamma-glutamyl hydrolase	Gallus gallus	66-90
7840619-2	1995	PLP caused a concentration-dependent inhibition of citrate transport with an IC50 value of 0.09 mM.	Citric Acid	51-58	pyridoxal phosphatase	Homo sapiens	0-3
7719722-7	1995	Citrate, a cytosolic precursor to acetyl-CoA formation, caused stimulation of C-4 (phrenic) output.	Citric Acid	0-7	complement C4A	Rattus norvegicus	78-81
7840619-4	1995	Substrate protection studies demonstrated that substrates for the tricarboxylate transporter (i.e., citrate, isocitrate, phosphoenolpyruvate, and malate) effectively protected against PLP inhibition, whereas other organic anions which are not transported by the tricarboxylate carrier (i.e., malonate, alpha-ketoglutarate, phosphate, and succinate) afforded considerably less protection.	Citric Acid	100-107	pyridoxal phosphatase	Homo sapiens	184-187
7840619-5	1995	Kinetic studies in which the transport rate was measured at varying citrate and PLP concentrations indicated that PLP caused an increase in the apparent Km of transport with little change in the Vmax, thereby resulting in a primarily competitive inhibition pattern.	Citric Acid	68-75	pyridoxal phosphatase	Homo sapiens	114-117
7983356-5	1994	The SMI-32 staining results are optimal with citrate buffer at pH 2.5 and 2-hr irradiation at 90 degrees C, whereas MAP-2 staining results are optimal with citrate buffer at pH 4.5 and 10-min full-power irradiation.	Citric Acid	156-163	microtubule associated protein 2	Homo sapiens	116-121
7741527-5	1995	The factors governing competitive interactions between SRB and other anaerobes involved in methanogenesis is discussed in the context of literature data on sulphate wastewater treatment and with particular reference to laboratory and full-scale digestion of citric acid production wastewater.	Citric Acid	258-269	chaperonin containing TCP1 subunit 4	Homo sapiens	55-58
7483148-5	1995	The major biochemical characteristics in RTA patients compared with patients without RTA were: (a) significantly higher urinary pH, (b) significantly lower excretion of citric acid, (c) no significant difference in calcium excretion and (d) a tendency toward lower titratable acidity and ammonium excretion.	Citric Acid	169-180	MAS related GPR family member F	Homo sapiens	41-44
7526817-7	1994	The correlation of citrate and EDTA fibrinogen values (fibrometer) was r = .9718; for citrate and special anticoagulant plasma, r = .9717.	Citric Acid	19-26	fibrinogen beta chain	Homo sapiens	36-46
7740458-2	1994	At a fixed concentration of APC the prolongation of the APTT is dependent on the activator, the CaCl2 concentration, the citrate concentration in the sample, and on sample handling.	Citric Acid	121-128	APC regulator of WNT signaling pathway	Homo sapiens	28-31
7527943-5	1994	Altogether, microwave boiling of the tissue sections in citrate buffer clearly improved the immunoreactivity for cytokeratin 18, oestrogen receptor, Ki-67 protein, PCNA, p53 protein, retinoblastoma gene protein and c-erbB-2 protein.	Citric Acid	56-63	keratin 18	Homo sapiens	113-154
7929313-10	1994	The resulting depletion of citric acid cycle intermediates was compensated by anaplerosis at the level of pyruvate carboxylase.	Citric Acid	27-38	LOW QUALITY PROTEIN: pyruvate carboxylase, mitochondrial	Oryctolagus cuniculus	106-126
8000525-5	1994	Studies on the regulation of aconitase A synthesis using an acnA-lacZ translational fusion showed that the acnA gene resembles other citric acid cycle genes in being subject to CRP-mediated catabolite repression and ArcA-mediated anaerobic repression.	Citric Acid	133-144	catabolite gene activator protein	Escherichia coli	177-180
8091252-1	1994	Animal models suggest that citrate-containing compounds augment absorption of aluminum from food and tap water, causing aluminum accumulation in bone and brain despite normal renal function.	Citric Acid	27-34	nuclear RNA export factor 1	Homo sapiens	101-104
7527943-5	1994	Altogether, microwave boiling of the tissue sections in citrate buffer clearly improved the immunoreactivity for cytokeratin 18, oestrogen receptor, Ki-67 protein, PCNA, p53 protein, retinoblastoma gene protein and c-erbB-2 protein.	Citric Acid	56-63	proliferating cell nuclear antigen	Homo sapiens	164-168
7527943-5	1994	Altogether, microwave boiling of the tissue sections in citrate buffer clearly improved the immunoreactivity for cytokeratin 18, oestrogen receptor, Ki-67 protein, PCNA, p53 protein, retinoblastoma gene protein and c-erbB-2 protein.	Citric Acid	56-63	tumor protein p53	Homo sapiens	170-173
7527943-5	1994	Altogether, microwave boiling of the tissue sections in citrate buffer clearly improved the immunoreactivity for cytokeratin 18, oestrogen receptor, Ki-67 protein, PCNA, p53 protein, retinoblastoma gene protein and c-erbB-2 protein.	Citric Acid	56-63	RB transcriptional corepressor 1	Homo sapiens	183-197
7527943-5	1994	Altogether, microwave boiling of the tissue sections in citrate buffer clearly improved the immunoreactivity for cytokeratin 18, oestrogen receptor, Ki-67 protein, PCNA, p53 protein, retinoblastoma gene protein and c-erbB-2 protein.	Citric Acid	56-63	erb-b2 receptor tyrosine kinase 2	Homo sapiens	215-223
24310015-6	1994	Of the citric-acid cycle enzymes, malate dehydrogenase, fumarase, fumarate reductase and an NADP-specific isocitrate dehydrogenase were readily detectable but no aconitase or citrate synthase activity was found.	Citric Acid	7-18	malic enzyme 1	Homo sapiens	34-54
7979805-7	1994	Seminal prolactin levels in leucocytospermic subjects were more associated with citric acid concentration than with corrected fructose, suggesting that prolactin is also secreted by the prostate.	Citric Acid	80-91	prolactin	Homo sapiens	8-17
7979805-7	1994	Seminal prolactin levels in leucocytospermic subjects were more associated with citric acid concentration than with corrected fructose, suggesting that prolactin is also secreted by the prostate.	Citric Acid	80-91	prolactin	Homo sapiens	152-161
7816745-5	1994	The age-related decrease in muscular glucose 6-phosphate, pyruvate and alanine concentrations and increase in citrate concentration were consistent with the age-related decreased hexokinase and increased citrate synthase activities.	Citric Acid	110-117	citrate synthase	Rattus norvegicus	204-220
7523644-7	1994	We suggest that the boiling of sections in citrate buffer is exposing an epitope for the anti-PGP9.5 antibody which is inaccessible in the native or fixed state and therefore we would recommend retesting of antibody specificity following non-enzymatic retrieval of antigen.	Citric Acid	43-50	ubiquitin C-terminal hydrolase L1	Homo sapiens	94-100
24310015-6	1994	Of the citric-acid cycle enzymes, malate dehydrogenase, fumarase, fumarate reductase and an NADP-specific isocitrate dehydrogenase were readily detectable but no aconitase or citrate synthase activity was found.	Citric Acid	7-18	fumarate hydratase	Homo sapiens	56-64
8080091-5	1994	The method was used to demonstrate association between two enzymes of the mitochondrial citric acid cycle, malate dehydrogenase and citrate synthase, and between the lysosomal hydrolases, beta-galactosidase and cathepsin A.	Citric Acid	88-99	malic enzyme 1	Homo sapiens	107-127
8080091-5	1994	The method was used to demonstrate association between two enzymes of the mitochondrial citric acid cycle, malate dehydrogenase and citrate synthase, and between the lysosomal hydrolases, beta-galactosidase and cathepsin A.	Citric Acid	88-99	citrate synthase	Homo sapiens	132-148
8195591-2	1994	The IgM was digested at a pepsin-to-IgM ratio of 1:200 (w/w) in 100 mM citrate buffer (pH 4.5) at 37 degrees C for 2 h. During digestion, the light (L) chain (27 kDa) of IgM remained undegraded, whereas the heavy (H) chain disappeared and two new bands of 44 and 48 kDa appeared.	Citric Acid	71-78	immunoglobulin heavy constant mu	Mus musculus	4-7
7511585-11	1994	In conjunction with NOS, citric acid cycle enzymes that covert fumarate to oxaloacetate (fumarase and malate dehydrogenase) and oxaloacetate to aspartate (aspartate transaminase), AS and AL form a novel arginine-citrulline cycle that enables high output NO production by cells.	Citric Acid	25-36	fumarate hydratase	Homo sapiens	89-97
7912941-5	1994	PCNA immunoreactivity in sections microwaved twice in citrate buffer was not satisfactory.	Citric Acid	54-61	proliferating cell nuclear antigen	Homo sapiens	0-4
7511585-11	1994	In conjunction with NOS, citric acid cycle enzymes that covert fumarate to oxaloacetate (fumarase and malate dehydrogenase) and oxaloacetate to aspartate (aspartate transaminase), AS and AL form a novel arginine-citrulline cycle that enables high output NO production by cells.	Citric Acid	25-36	malic enzyme 1	Homo sapiens	102-122
8117658-11	1994	The location of citrate binding in the active site leads to a plausible catalytic mechanism for aldose reductase.	Citric Acid	16-23	aldo-keto reductase family 1 member B	Homo sapiens	96-112
8088501-7	1994	From the kinetic data it appears that inhibition by mono- and deca-vanadate of ACL with respect to both ATP and citrate was of competitive nature.	Citric Acid	112-119	ATP citrate lyase	Rattus norvegicus	79-82
8117658-0	1994	An anion binding site in human aldose reductase: mechanistic implications for the binding of citrate, cacodylate, and glucose 6-phosphate.	Citric Acid	93-100	aldo-keto reductase family 1 member B	Homo sapiens	31-47
8088501-10	1994	Endogenous (auto)phosphorylation of the ACL histidine as well as its response to vanadate depended on the presence of he substrate (citrate + CoA).	Citric Acid	132-139	ATP citrate lyase	Rattus norvegicus	40-43
8120184-6	1994	Milk fat percentage and yield were lower, and milk citrate concentration was higher, for the trans than the cis treatment.	Citric Acid	51-58	Weaning weight-maternal milk	Bos taurus	46-50
7823585-4	1994	Recently, several anti-estrogen receptor (ER) antibodies have appeared which can be successfully employed to assay routinely prepared tissue sections if used in conjunction with new antigen-retrieval techniques such as the microwave oven and citrate buffers.	Citric Acid	242-249	estrogen receptor 1	Homo sapiens	23-40
7762449-6	1994	We consider the most likely explanation is that other factors necessary for the optimum activity of lactoferrin were not present or in inappropriate concentration, e.g. sIgA, lysozyme, citrate, bicarbonate.	Citric Acid	185-192	lactotransferrin	Bos taurus	100-111
7929613-5	1994	Coordinated inhibition of glycolytic flux mediated by effects of citrate on PFK1 and PFK2 in muscles and liver results in an associated inhibition of glucose uptake.	Citric Acid	65-72	phosphofructokinase, muscle	Homo sapiens	76-80
7929613-5	1994	Coordinated inhibition of glycolytic flux mediated by effects of citrate on PFK1 and PFK2 in muscles and liver results in an associated inhibition of glucose uptake.	Citric Acid	65-72	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	85-89
8115281-4	1994	Citrate production, the major function of prostate, is directly regulated by prolactin.	Citric Acid	0-7	prolactin	Homo sapiens	77-86
7783702-6	1994	By chelating free Ca ions, citrate reduces self-aggregation of THP molecules and turns promoting THPs into inhibitors of calcium oxalate crystal aggregation.	Citric Acid	27-34	uromodulin	Homo sapiens	63-66
7816003-4	1994	Results of this study indicate that Al compounds (chloride and citrate) at concentrations as low as 0.37 mumol Al/l inhibit erythropoiesis in vitro through a mechanism dependent upon the availability of transferrin to bind to aluminum.	Citric Acid	63-70	transferrin	Mus musculus	203-214
8115281-6	1994	The mechanisms of prolactin regulation of citrate production by prostate epithelial cells include a.	Citric Acid	42-49	prolactin	Homo sapiens	18-27
8115281-7	1994	Regulation of the pmAAT gene, which results in an increase in the biosynthesis of mAAT and, ultimately, an increase in citrate synthesis (the prolactin regulation of gene transcription is mediated via <protein-id="5579">PKC).	Citric Acid	119-126	prolactin	Homo sapiens	142-151
16727547-2	1994	Citrate concentration was determined for each lot of BSA, and then correlated with differences noted in the ability of BSA lots to support embryo development.	Citric Acid	0-7	albumin	Bos taurus	53-56
16727547-5	1994	Citrate content (based on 3.2% BSA) of the medium varied from 320 to 1280 microM.	Citric Acid	0-7	albumin	Bos taurus	31-34
8285211-0	1993	Citrate and calcium effects on Tamm-Horsfall glycoprotein as a modifier of calcium oxalate crystal aggregation.	Citric Acid	0-7	uromodulin	Homo sapiens	31-57
8285211-6	1993	With an additional 3.5 mM of citrate, inhibition of Ac was 56 +/- 5% by normal and 34 +/- 6% by stone former THP (P = 0.021), and all seven stone former THP again inhibited Ac.	Citric Acid	29-36	uromodulin	Homo sapiens	109-112
8285211-6	1993	With an additional 3.5 mM of citrate, inhibition of Ac was 56 +/- 5% by normal and 34 +/- 6% by stone former THP (P = 0.021), and all seven stone former THP again inhibited Ac.	Citric Acid	29-36	uromodulin	Homo sapiens	153-156
7908029-1	1993	The effects of four angiotensin-converting enzyme (ACE) inhibitors, captopril, enalapril, quinapril and alacepril, on the cough responses caused by citric acid and capsaicin inhalation were studied in normal and bronchitic guinea-pigs.	Citric Acid	148-159	LOW QUALITY PROTEIN: angiotensin-converting enzyme	Cavia porcellus	51-54
7908029-5	1993	When administered daily for 8 days, captopril was the only ACE inhibitor which significantly increased the number of coughs due to citric acid inhalation.	Citric Acid	131-142	LOW QUALITY PROTEIN: angiotensin-converting enzyme	Cavia porcellus	59-62
8397139-2	1993	Recently, ferric ion chelated to citrate (Fe-citrate) was identified as the major non-transferrin-bound iron in the serum of GH patients.	Citric Acid	33-40	transferrin	Homo sapiens	86-97
8213795-9	1993	In conclusion, the local pain experienced after subcutaneous administration of epoetin alfa preparations is mainly caused by the citrate component of the buffered solution.	Citric Acid	129-136	erythropoietin	Homo sapiens	79-86
8345822-1	1993	Citrate synthase catalyzes the condensation of acetyl-coenzyme A (CoA) and oxaloacetic acid to form citric acid.	Citric Acid	100-111	citrate synthase	Homo sapiens	0-16
8395934-1	1993	When phenylalanine was incubated with myeloperoxidase (MPO) and NADH in citrate buffer (pH 4.5), o-, m-, and p-tyrosines were identified as hydroxylated products.	Citric Acid	72-79	myeloperoxidase	Homo sapiens	38-53
7686953-1	1993	In the course of studies of desmosomes, we found trichohyalin, a 200-kDa protein of the inner root sheath and medulla, in a citric acid-insoluble fraction ("desmosome preparation") from tongue epithelium.	Citric Acid	124-135	trichohyalin	Homo sapiens	49-61
8514278-2	1993	One such antibody, MIB1, recognizes a fixation and embedding resistant epitope on the Ki-67 protein if sections are previously microwaved in a citrate buffer.	Citric Acid	143-150	MIB E3 ubiquitin protein ligase 1	Homo sapiens	19-23
8514278-2	1993	One such antibody, MIB1, recognizes a fixation and embedding resistant epitope on the Ki-67 protein if sections are previously microwaved in a citrate buffer.	Citric Acid	143-150	antigen identified by monoclonal antibody Ki 67	Mus musculus	86-91
8479597-8	1993	Citrate inhibited mMDH via an uncompetitive mechanism and cMDH via a noncompetitive mechanism.	Citric Acid	0-7	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	18-22
8450120-5	1993	A surface conditioning of the dentin grains by 3% citric acid or by 2.5% minocycline-HCl increased the initial attachment of HPDL cells significantly (p &lt; 0.05).	Citric Acid	50-61	4-hydroxyphenylpyruvate dioxygenase like	Homo sapiens	125-129
15159875-0	1993	[Verapamil enhancement of antitumor activity of mitoxantrone on ACC-22 cells in citro] The combined effect of verapamil and DHAD on the growth of human adenoid cystic carcinoma cell line(ACC-2) in vitro was investigated.In combination, VP and DHAD had synergistic inhibitory effect.VP enhanced the cytotoxicity of DHAD in ACC-2 cells and significantly inhibited the cell proliferation.VP also potentiated the inhibitory effect of DHAD on colongenic ability of ACC-2 cell,suggesting it enhance the cytocidal effect of DHAD on human adenoid cystic carcinoma.	Citric Acid	80-85	acetyl-CoA carboxylase beta	Homo sapiens	64-69
8447387-4	1993	Muscle citrate concentration at the end of exercise correlated significantly with CS activity (r = 0.70; P &lt; 0.005) and was slightly but not significantly higher after training (0.80 +/- 0.19 vs. 0.54 +/- 0.19 mmol/kg dry wt; P = 0.16).	Citric Acid	7-14	citrate synthase	Homo sapiens	82-84
8440713-12	1993	This, together with the citrate data, strongly suggests that p93/calnexin, in isolated nuclear envelopes, is mostly bound to the inner membrane.	Citric Acid	24-31	calnexin	Homo sapiens	65-73
8438789-6	1993	An immunoglobulin M/lambda anti-platelet antibody was found to react in serum as well as in plasma EDTA at room temperature, but not at 37 degrees C. This antibody appeared to be directed against GP78 membrane antigen because this antigen was not detectable by immunofluorescence in platelets collected in EDTA and Na-citrate anticoagulant, whereas a fluorescence signal was revealed in platelets collected in citrate-theophylline-adenosine-dipyridamole.	Citric Acid	318-325	autocrine motility factor receptor	Homo sapiens	196-200
1298434-5	1992	A 30- to 60-s application of citric acid left a significantly greater coating thickness than all other treatments, whereas a 3-min application of citric acid removed significantly more HA than untreated controls.	Citric Acid	146-157	T cell immune regulator 1, ATPase H+ transporting V0 subunit a3	Homo sapiens	123-126
8249366-2	1993	After treatment with citric acid at pH 3 and chloroquine, the expression of HLA class I was significantly reduced, while the density of the molecules GPIa/IIa, GPIIb, and GPIIb/IIIa (GP = glycoprotein) carrying "thrombocyte-specific" antigens was not or only weakly decreased on the surface of the platelets.	Citric Acid	21-32	multimerin 1	Homo sapiens	150-154
8249366-2	1993	After treatment with citric acid at pH 3 and chloroquine, the expression of HLA class I was significantly reduced, while the density of the molecules GPIa/IIa, GPIIb, and GPIIb/IIIa (GP = glycoprotein) carrying "thrombocyte-specific" antigens was not or only weakly decreased on the surface of the platelets.	Citric Acid	21-32	integrin subunit alpha 2b	Homo sapiens	160-165
8249366-2	1993	After treatment with citric acid at pH 3 and chloroquine, the expression of HLA class I was significantly reduced, while the density of the molecules GPIa/IIa, GPIIb, and GPIIb/IIIa (GP = glycoprotein) carrying "thrombocyte-specific" antigens was not or only weakly decreased on the surface of the platelets.	Citric Acid	21-32	integrin subunit alpha 2b	Homo sapiens	171-176
7805589-3	1993	When glucose was the labeling substrate, incorporation due to pyruvate carboxylation should be observed in the C-2 position in glutamine and the C-4 position in citrate.	Citric Acid	161-168	complement C4A (Rodgers blood group)	Homo sapiens	145-148
7805589-7	1993	Altogether, these observations led to the conclusion that glutamine precursors and citrate are either produced in different types of astrocytes or in different tricarboxylic acid cycles, situated in functionally different mitochondria in the same cell, and that in all likelihood pyruvate carboxylase is expressed differently in these mitochondria.	Citric Acid	83-90	pyruvate carboxylase	Homo sapiens	280-300
8258312-6	1993	The effect of the phosphate, succinate and citrate anions on the electron transfer reaction between cytochrome c and cytochrome c oxidase is important as a control of the respiration process in mitochondria at physiological conditions.	Citric Acid	43-50	cytochrome c, somatic	Equus caballus	100-112
8258312-6	1993	The effect of the phosphate, succinate and citrate anions on the electron transfer reaction between cytochrome c and cytochrome c oxidase is important as a control of the respiration process in mitochondria at physiological conditions.	Citric Acid	43-50	cytochrome c, somatic	Equus caballus	117-129
8487208-4	1993	Changes in the aerobic oxidative capacity of the stimulated muscles were judged from increases in citrate synthase activity, representing the constant-proportion enzyme group of the citric acid cycle.	Citric Acid	182-193	citrate synthase	Rattus norvegicus	98-114
1479587-2	1992	Citric acid analogues (+/-)-12a,b and (+/-)-17a,b, where one of the primary carboxylates has been replaced by a sulfoximinoyl and a 3-(3-hydroxy-beta-lactamyl) moiety, respectively, have been synthesized and evaluated as inhibitors of ATP-citrate lyase.	Citric Acid	0-11	ATP citrate lyase	Homo sapiens	235-252
1443123-7	1992	This increased citrate level could be related to a mobilization of glucose stored as glycogen since liver glycogen was decreased by TNF-alpha injection (P &lt; 0.05).	Citric Acid	15-22	tumor necrosis factor	Rattus norvegicus	132-141
1301396-1	1992	Prolactin (PRL) has been reported to stimulate citrate production and the activity of mitochondrial aspartate aminotransferase (mAAT) and its precursor form pmAAT in prostate epithelial cells.	Citric Acid	47-54	prolactin	Sus scrofa	0-9
1301396-1	1992	Prolactin (PRL) has been reported to stimulate citrate production and the activity of mitochondrial aspartate aminotransferase (mAAT) and its precursor form pmAAT in prostate epithelial cells.	Citric Acid	47-54	prolactin	Sus scrofa	11-14
1435878-5	1992	A transferrin-independent non-heme iron uptake activity was, however, detected in both infected and uninfected erythrocytes when iron was presented to the cells as 55Fe-NTA or 55Fe-citrate.	Citric Acid	181-188	transferrin	Homo sapiens	2-13
1333636-1	1992	In plasma from healthy subjects a coupling was identified between von Willebrand factor (vWf), fibrinogen (fg), and fibronectin (fn) that was dependent of anticoagulants heparin, EDTA, and citrate.	Citric Acid	189-196	von Willebrand factor	Homo sapiens	66-87
1333636-1	1992	In plasma from healthy subjects a coupling was identified between von Willebrand factor (vWf), fibrinogen (fg), and fibronectin (fn) that was dependent of anticoagulants heparin, EDTA, and citrate.	Citric Acid	189-196	von Willebrand factor	Homo sapiens	89-92
1333636-1	1992	In plasma from healthy subjects a coupling was identified between von Willebrand factor (vWf), fibrinogen (fg), and fibronectin (fn) that was dependent of anticoagulants heparin, EDTA, and citrate.	Citric Acid	189-196	fibrinogen beta chain	Homo sapiens	95-105
1333636-1	1992	In plasma from healthy subjects a coupling was identified between von Willebrand factor (vWf), fibrinogen (fg), and fibronectin (fn) that was dependent of anticoagulants heparin, EDTA, and citrate.	Citric Acid	189-196	fibronectin 1	Homo sapiens	116-127
1369009-4	1992	Gelation was initiated by addition of an oil-soluble acid thereby reducing the pH of the alginate solution and releasing soluble Ca2+ from the citrate complex.	Citric Acid	143-150	carbonic anhydrase 2	Homo sapiens	129-132
1288767-4	1992	A significant dose-dependent reduction of complement activation was achieved by anticoagulating whole blood with 10 U/ml heparin (p &lt; 0.05) if compared with serum whereas citrate inhibited more effectively the generation of C5a (desarg) even at a low concentration (ACD-B 1:20) (p &lt; 0.01).	Citric Acid	174-181	complement C5a receptor 1	Homo sapiens	227-230
1643943-0	1992	Relationship between gallium 67 citrate scanning and transferrin receptor expression in lung diseases.	Citric Acid	32-39	transferrin receptor	Homo sapiens	53-73
1324911-1	1992	We have obtained iron K-edge extended x-ray absorption fine structure spectra of the plant mitochondrial aconitase in its active state, in the presence (aconitase (+)) and absence (aconitase (-)) of the substrate citrate.	Citric Acid	213-220	aconitase 2	Homo sapiens	91-114
1514598-2	1992	Through utilization of the citrate clamp technique and the calcium clamp technique we were able, in a standardized way, to stimulate and suppress the parathyroid hormone secretion.	Citric Acid	27-34	parathyroid hormone	Homo sapiens	150-169
1514598-5	1992	During the citrate clamp, preceded by normal calcemia, serum intact parathyroid hormone peaked to a maximum after 5-10 min, four to six times above baseline concentration and then declined to a steady state two to three times above baseline concentration.	Citric Acid	11-18	parathyroid hormone	Homo sapiens	68-87
1514598-6	1992	During the citrate clamp, preceded by hypercalcemia induced by a calcium clamp, serum intact parathyroid hormone also peaked immediately to about five to nine times above its suppressed level, approximately two times above the baseline concentration.	Citric Acid	11-18	parathyroid hormone	Homo sapiens	93-112
1526029-0	1992	Effect of pH and citrate on binding of iron and gallium by transferrin in serum.	Citric Acid	17-24	transferrin	Homo sapiens	59-70
1526029-3	1992	The effect of pH ana citrate on the binding of 67Ga (a radiotracer used as an analog of Al) to transferrin in normal human serum was tested in the presence of physiological concentrations of CO2.	Citric Acid	21-28	transferrin	Homo sapiens	95-106
1644826-11	1992	Growth phenotype analysis of the IDH1 disruption strains revealed that they grew at a reduced rate on the nonfermentable carbon sources examined (glycerol, lactate, and acetate), consistent with NAD(+)-dependent isocitrate dehydrogenase performing a critical role in oxidative function of the citric acid cycle.	Citric Acid	293-304	isocitrate dehydrogenase (NAD(+)) IDH1	Saccharomyces cerevisiae S288C	33-37
1643943-7	1992	These findings suggest that 67Ga-citrate initially combines with transferrin in the blood and then the complex is incorporated into cells through TFR.	Citric Acid	33-40	transferrin	Homo sapiens	65-76
1643943-7	1992	These findings suggest that 67Ga-citrate initially combines with transferrin in the blood and then the complex is incorporated into cells through TFR.	Citric Acid	33-40	transferrin receptor	Homo sapiens	146-149
1535194-1	1992	Phosphofructokinases from granulocytes isolated from insulin-resistant patients, mainly those from type II diabetics where the degree of insulin resistance was more pronounced, exhibit some changes in their kinetic behavior when assayed under allosteric conditions, characterized by an increased affinity for fructose-6-phosphate, being more resistant to ATP inhibition while it became more sensitive to citrate inhibitory effect.	Citric Acid	404-411	insulin	Homo sapiens	137-144
1414126-8	1992	The total yield of human insulin was about 5 mg/L The Zinc insulin crystals were obtained with amorphous human insulin using citrate method.	Citric Acid	125-132	insulin	Homo sapiens	25-32
1593151-2	1992	We have purified trichohyalin in milligram quantities from a citric acid-insoluble fraction derived from pig tongue epithelium.	Citric Acid	61-72	trichohyalin	Sus scrofa	17-29
1593151-3	1992	Trichohyalin was extracted under conditions of low ionic strength from the citric acid-insoluble fraction, separated by gel-filtration chromatography in buffer containing 1 M NaBr, and concentrated by ion-exchange chromatography in buffer containing 4 M urea.	Citric Acid	75-86	trichohyalin	Sus scrofa	0-12
1535194-1	1992	Phosphofructokinases from granulocytes isolated from insulin-resistant patients, mainly those from type II diabetics where the degree of insulin resistance was more pronounced, exhibit some changes in their kinetic behavior when assayed under allosteric conditions, characterized by an increased affinity for fructose-6-phosphate, being more resistant to ATP inhibition while it became more sensitive to citrate inhibitory effect.	Citric Acid	404-411	insulin	Homo sapiens	53-60
1414126-8	1992	The total yield of human insulin was about 5 mg/L The Zinc insulin crystals were obtained with amorphous human insulin using citrate method.	Citric Acid	125-132	insulin	Homo sapiens	59-66
1414126-8	1992	The total yield of human insulin was about 5 mg/L The Zinc insulin crystals were obtained with amorphous human insulin using citrate method.	Citric Acid	125-132	insulin	Homo sapiens	59-66
1314575-6	1992	Substituting chloride anion for citrate abrogated the increase in angiotensin I-converting enzyme activity.	Citric Acid	32-39	angiotensinogen	Homo sapiens	66-79
1623322-5	1992	After processing 13 cycles of 400 ml whole blood/HES-citrate-volume a total yield of 9.20 +/- 2.80 x 10(9) white cells were collected in volumes of 125 ml.	Citric Acid	53-60	ribosome binding protein 1	Homo sapiens	49-52
1533471-5	1992	Phosphofructokinase (PFK) isolated from PFKL-overexpressing clones was more inhibited by ATP and citrate and less activated by fructose-6-phosphate than control PFK; similar results were obtained when PFK preparations from DS and control fibroblasts were compared.	Citric Acid	97-104	phosphofructokinase, liver type	Homo sapiens	40-44
1593546-0	1992	Purification of an embryotrophic factor from commercial bovine serum albumin and its identification as citrate.	Citric Acid	103-110	albumin	Oryctolagus cuniculus	63-76
1747128-1	1991	Binding of aluminium by human transferrin in the presence of human albumin and citrate.	Citric Acid	79-86	transferrin	Homo sapiens	30-41
1375080-4	1992	In the presence of citric acid, chromium binding to transferrin is five times more than aluminum.	Citric Acid	19-30	transferrin	Homo sapiens	52-63
1316186-3	1992	Superoxide radical was generated from the reaction of H2O2 with Co(II), but was inhibited when Co(II) was chelated with adenosine 5"-diphosphate or citrate.	Citric Acid	148-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-70
1316186-3	1992	Superoxide radical was generated from the reaction of H2O2 with Co(II), but was inhibited when Co(II) was chelated with adenosine 5"-diphosphate or citrate.	Citric Acid	148-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-101
1394906-3	1992	When certain substrates of citric acid cycle were added to liver mitochondria of Oncomelania snail, we found that oxidative phosphorylation increased to 0.353-0.444 mumol O2/mg protein.20 min.	Citric Acid	27-38	snail family transcriptional repressor 1	Homo sapiens	93-98
1747128-6	1991	Competitive assays of binding of Al3+ to transferrin in the presence of citrate and human serum albumin at molar ratios corresponding to those found in normal plasma showed that a considerable amount of Al3+ was not bound to transferrin.	Citric Acid	72-79	transferrin	Homo sapiens	41-52
1897514-4	1991	Initially, the aggregation of PPACK-PRP was nearly twice that of citrate-PRP.	Citric Acid	65-72	complement component 4 binding protein alpha	Homo sapiens	73-76
1722939-5	1991	The shift from mechanical to gustatory stimulation with 0.5% citric acid enhanced significantly the secretion of amylase and kallikrein (P less than 0.009), while application of 5.0% citric acid increased the secretion of both acinar products (P less than 0.009) more than kallikrein.	Citric Acid	61-72	kallikrein related peptidase 4	Homo sapiens	125-135
1722939-5	1991	The shift from mechanical to gustatory stimulation with 0.5% citric acid enhanced significantly the secretion of amylase and kallikrein (P less than 0.009), while application of 5.0% citric acid increased the secretion of both acinar products (P less than 0.009) more than kallikrein.	Citric Acid	183-194	kallikrein related peptidase 4	Homo sapiens	273-283
1776362-3	1991	These compounds were absent in an SDS extract of cell walls or in a hot-citrate extract of mnn9 cells.	Citric Acid	72-79	mannosyltransferase complex subunit MNN9	Saccharomyces cerevisiae S288C	91-95
1778900-8	1991	These muscles showed marked metabolic adaptations: training increased the activity levels of enzymes involved in the citric acid cycle (citrate synthase, CS) and the beta-oxidation of fatty acids (3 hydroxyacyl CoA dehydrogenase, HAD).	Citric Acid	117-128	citrate synthase	Rattus norvegicus	136-152
1718493-8	1991	Complex formation between alpha 2M and APC was found to be almost completely inhibited by EDTA, but to a lesser extent by citrate.	Citric Acid	122-129	alpha-2-macroglobulin	Homo sapiens	26-34
1833982-7	1991	Biopsies taken after the 400 mU insulin infusion showed decreases in acetylcarnitine and citrate and increases in the fractional activity of glycogen synthase.	Citric Acid	89-96	insulin	Homo sapiens	32-39
1833982-10	1991	The insulin-mediated decreases in acetylcarnitine and citrate suggest an activation of the tricarboxylic acid cycle in skeletal muscle but an absence of the normal response to replenish these intermediates.	Citric Acid	54-61	insulin	Homo sapiens	4-11
1897514-6	1991	The improved stability of the response obtained from samples anticoagulated with PPACK was due to the absence of citrate, since PRP containing both citrate and PPACK became less responsive over time in a manner similar to PRP which contained only citrate.	Citric Acid	148-155	complement component 4 binding protein alpha	Homo sapiens	128-131
1897514-6	1991	The improved stability of the response obtained from samples anticoagulated with PPACK was due to the absence of citrate, since PRP containing both citrate and PPACK became less responsive over time in a manner similar to PRP which contained only citrate.	Citric Acid	148-155	complement component 4 binding protein alpha	Homo sapiens	128-131
1765569-4	1991	There was a significant relationship between high PMN elastase levels and low citric acid levels in semen; fructose and neutral alpha-glucosidase were not related to PMN elastase.	Citric Acid	78-89	elastase, neutrophil expressed	Homo sapiens	50-62
1765569-5	1991	Semen samples with increased PMN elastase levels (greater than 250 and greater than 1,000 ng/ml) showed a high incidence of pathologic citric acid levels (67% and 73%, respectively).	Citric Acid	135-146	elastase, neutrophil expressed	Homo sapiens	29-41
1991136-5	1991	Spermine, which contributes to an activation of Ca2(+)-sensitive dehydrogenases of the citric acid cycle by enhancing Ca2+ uptake into mitochondria, can activate citrate synthase directly, and is responsible for the stimulation of oxidative metabolism in mitochondria.	Citric Acid	87-98	citrate synthase	Homo sapiens	162-178
1808706-6	1991	In the presence of citrate (5 mmol/l), which is only slightly inhibitory (14%), the promoting effect of THP is reversed into aggregation inhibition (up to 55%).	Citric Acid	19-26	uromodulin	Homo sapiens	104-107
1931558-4	1991	All of the CSF samples showed peaks for lactate, L-alanine, acetate, glutamine, citrate, creatine/creatinine and sugar resonances.	Citric Acid	80-87	colony stimulating factor 2	Homo sapiens	11-14
1795217-2	1991	This vitamin takes part in the activity of the enzyme methylmalonyl coenzyme A mutase, involved in the conversion of propionyl CoA to succinyl CoA, an intermediary product of the citrate cycle, and of the 5-methyltetrahydrofolate: homocystein methyltransferase, working in the metabolism of methionin and in DNA synthesis.	Citric Acid	179-186	methylmalonyl-CoA mutase	Homo sapiens	54-85
1764503-3	1991	The first procedure is based on the conversion of oxalacetate generated from pyruvate to 14C-labelled citrate in the presence of [1-14C]acetyl-CoA and citrate synthase.	Citric Acid	102-109	citrate synthase	Rattus norvegicus	151-167
1901574-4	1991	Enzyme activities of the citric acid cycle, i.e., isocitrate dehydrogenase, 2-oxoglutarate sythase, succinate dehydrogenase, fumarase, and malate dehydrogenase, were observed.	Citric Acid	25-36	fumarate hydratase	Homo sapiens	125-133
1901574-4	1991	Enzyme activities of the citric acid cycle, i.e., isocitrate dehydrogenase, 2-oxoglutarate sythase, succinate dehydrogenase, fumarase, and malate dehydrogenase, were observed.	Citric Acid	25-36	malic enzyme 2	Homo sapiens	139-159
2037846-0	1991	Kinetics of the release of aluminum from human serum dialuminum transferrin to citrate.	Citric Acid	79-86	transferrin	Homo sapiens	64-75
2037846-1	1991	The kinetics of release of Al3+ from human serum dialuminum transferrin (Al2Tf) to citrate were investigated at 37 degrees C, pH 7.4, mu = 0.7 M, by difference UV spectrophotometry.	Citric Acid	83-90	transferrin	Homo sapiens	60-71
2057326-2	1991	The pipette solution, used for internal dialysis of the cells, contained a high concentration, 60 mM or 25 mM, of citrate as a non-saturable low-affinity Ca2(+)-chelating compound.	Citric Acid	114-121	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	154-157
1892612-6	1991	; 24 hr after warfarin administration, prothrombin time was determined on citrate blood specimens and the animals were submitted to autopsy.	Citric Acid	74-81	coagulation factor II	Rattus norvegicus	39-50
2221921-11	1990	On the other hand, 200 microM 3MP blocked completely the epimastigotes" catabolism of L-[U-14C]proline through the Kreb"s cycle via PEP-carboxykinase, as indicated by the disappearance of 14C label present in alanine, pyruvate, citrate, and isocitrate after 1 h of incubation in the presence of the labeled amino acid, while the amount of radioactivity present in alpha-ketoglutarate and malate doubled.	Citric Acid	228-235	phosphoenolpyruvate carboxykinase 1	Homo sapiens	132-149
2046827-6	1991	There was a stepwise decrease in the filtered load of citrate as GFR decreased, while its renal clearance was significantly reduced only at higher degrees of renal failure.	Citric Acid	54-61	Rap guanine nucleotide exchange factor 5	Homo sapiens	65-68
2046827-7	1991	This behavior was due to an increase in the fractional excretion of citrate which was inversely related to the decrease in GFR (p = 0.015).	Citric Acid	68-75	Rap guanine nucleotide exchange factor 5	Homo sapiens	123-126
2176871-14	1990	Together, these results imply that enzyme-catalyzed interconversion of citrate and isocitrate does not involve displacement of an endogenous fourth ligand, but rather addition of the anionic carboxylate ligand and a change in protonation state of a solvent species bound to Fea.	Citric Acid	71-78	FEA	Homo sapiens	274-277
2083485-6	1990	Adenosine-diphosphate (0.5-2 microM) or thrombin (0.1-0.4 NIH units ml-1) induced dose-dependent aggregation of platelets in citrate- or heparin-containing PRP; such aggregation was, however, not affected by ET-1 (1-100 microM) either.	Citric Acid	125-132	coagulation factor II, thrombin	Homo sapiens	40-48
2083485-6	1990	Adenosine-diphosphate (0.5-2 microM) or thrombin (0.1-0.4 NIH units ml-1) induced dose-dependent aggregation of platelets in citrate- or heparin-containing PRP; such aggregation was, however, not affected by ET-1 (1-100 microM) either.	Citric Acid	125-132	endothelin 1	Homo sapiens	208-212
16667849-9	1990	Malate, aspartate, glutamate, citrate, and 2-oxoglutarate were potent inhibitors of PEPC at pH 7 in the absence of glycerol, but their effectiveness was decreased by raising the pH to 8 and/or by adding glycerol.	Citric Acid	30-37	phosphoenolpyruvate carboxylase, housekeeping isozyme	Glycine max	84-88
2221051-3	1990	The rate of oxygen consumption or end-product formation of palmitoyl-L-carnitine and octanoate was not altered, but the rate of CPT I-dependent palmitoyl-CoA (plus L-carnitine) oxidation was reduced by LPS, when acetyl-CoA produced via beta-oxidation was directed toward citrate.	Citric Acid	271-278	carnitine palmitoyltransferase 1B	Rattus norvegicus	128-133
1666632-3	1991	Three 45TiO-complexes with diethylenetriaminepentaacetic acid, citric acid and human serum albumin showed the highest radioactivity levels in the blood over 6 h. The binding of the 45Ti with plasma transferrin in vitro and in vivo suggested that these compounds can be used for estimating the blood volume.	Citric Acid	63-74	transferrin	Rattus norvegicus	198-209
2146265-10	1990	Citrate increased the K0.5 for Rib-1,5-P2 without affecting the maximum activation, and AMP lowered the K0.5 for Rib-1,5-P2 without affecting the maximum activation.	Citric Acid	0-7	ribonuclease A family member 1, pancreatic	Homo sapiens	31-36
2118436-7	1990	Preoperative local intramuscular injections of citric, edetic, or hyaluronic acids in specified concentrations markedly enhanced subperiosteal BMP/NCP-induced bone formation.	Citric Acid	47-53	bone morphogenetic protein 1	Homo sapiens	143-146
1974251-2	1990	The phosphorylation of the Ser-1200 residue by cyclic AMP-dependent protein kinase transforms ACC from a citrate-independent form to a citrate-dependent form (10, 16).	Citric Acid	105-112	acetyl-CoA carboxylase alpha	Homo sapiens	94-97
1974251-2	1990	The phosphorylation of the Ser-1200 residue by cyclic AMP-dependent protein kinase transforms ACC from a citrate-independent form to a citrate-dependent form (10, 16).	Citric Acid	135-142	acetyl-CoA carboxylase alpha	Homo sapiens	94-97
2198251-8	1990	Mitochondria isolated from the IDH1 and IDH2 mutants exhibited a markedly reduced capacity for utilization of either isocitrate or citrate for respiratory O2 consumption.	Citric Acid	120-127	isocitrate dehydrogenase (NAD(+)) IDH1	Saccharomyces cerevisiae S288C	31-35
2364381-7	1990	Interleukin 6 stimulates hepatic lipogenesis by increasing hepatic citrate concentrations, the same mechanism by which TNF stimulates hepatic lipogenesis.	Citric Acid	67-74	interleukin 6	Rattus norvegicus	0-13
2198251-8	1990	Mitochondria isolated from the IDH1 and IDH2 mutants exhibited a markedly reduced capacity for utilization of either isocitrate or citrate for respiratory O2 consumption.	Citric Acid	120-127	isocitrate dehydrogenase (NAD(+)) IDH2	Saccharomyces cerevisiae S288C	40-44
1972922-4	1990	TNF administration results in increased hepatic levels of citrate, the primary allosteric activator of acetyl-CoA carboxylase, which is the major rate-limiting enzyme for fatty acid synthesis.	Citric Acid	58-65	tumor necrosis factor	Mus musculus	0-3
1972922-5	1990	The TNF-induced increase in citrate occurs within 15 min of administration, early enough to account for the acute rise in hepatic fatty acid synthesis seen by 30 min after TNF administration.	Citric Acid	28-35	tumor necrosis factor	Mus musculus	4-7
1972922-5	1990	The TNF-induced increase in citrate occurs within 15 min of administration, early enough to account for the acute rise in hepatic fatty acid synthesis seen by 30 min after TNF administration.	Citric Acid	28-35	tumor necrosis factor	Mus musculus	172-175
2198184-3	1990	Citrate gel electrophoresis of lysed erythrocytes, previously washed and incubated in 0.9% NaCl, gave accurate HbA1 values without interference from either abnormal Hb variants or labile glycosylation products.	Citric Acid	0-7	hemoglobin alpha, adult chain 1	Rattus norvegicus	111-115
2230664-7	1990	In addition to transferrin, aluminium was shown to be associated with citrate in serum, resulting in a low-molecular weight complex.	Citric Acid	70-77	transferrin	Rattus norvegicus	15-26
2383300-1	1990	Heparin sodium was assayed by turbidimetric measurement of the clotting time of bovine citrate plasma with thromboplastin, between the moment of recalcification and the moment of maximal speed of polymerization of the fibrinogen monomer, as marked by the turning-point of the trace of the turbidimetric record.	Citric Acid	87-94	coagulation factor III, tissue factor	Bos taurus	107-121
1980584-7	1990	Net synthesis of citric acid cycle intermediates is dependent on carbon dioxide fixation to pyruvate, catalyzed by pyruvate carboxylase (EC 6.4.1.1).	Citric Acid	17-28	pyruvate carboxylase	Homo sapiens	115-135
2324086-4	1990	Citrate at millimolar concentrations lowered calcium uptake of sperm in the presence of enhancer caltrin to near control levels.	Citric Acid	0-7	caltrin	Bos taurus	97-104
2341289-1	1990	A comparative study of carrier-free 67Ga-citrate uptake by Ehrlich ascites tumor cells in the presence of lactoferrin, transferrin and ferritin has demonstrated that lactoferrin considerably increases the uptake of 67Ga, and that this increase seems to be determined by its iron-load.	Citric Acid	41-48	transferrin	Mus musculus	119-130
2341289-1	1990	A comparative study of carrier-free 67Ga-citrate uptake by Ehrlich ascites tumor cells in the presence of lactoferrin, transferrin and ferritin has demonstrated that lactoferrin considerably increases the uptake of 67Ga, and that this increase seems to be determined by its iron-load.	Citric Acid	41-48	lactotransferrin	Mus musculus	166-177
2352102-6	1990	Treatment of cementum with citric acid pH 1.1 (4 minutes) followed by 5% sodium hypochlorite (5 minutes) caused a significant increase in fibronectin sorption with maximum retention upon subsequent exposure to serum (P less than 0.05).	Citric Acid	27-38	fibronectin 1	Homo sapiens	138-149
2352102-7	1990	Fibronectin sorption to cementum was: rapid, electrostatic in nature, competitive, reversible, Ca+(+)-facilitated, and maximized by prior treatment of the root with citric acid and sodium hypochlorite.	Citric Acid	165-176	fibronectin 1	Homo sapiens	0-11
2245005-6	1990	; 24 hr after warfarin administration, prothrombin time was determined on citrate blood specimens and the animals were submitted to autopsy.	Citric Acid	74-81	coagulation factor II	Rattus norvegicus	39-50
2385549-0	1990	Prolactin directly stimulates citrate production and mitochondrial aspartate aminotransferase of prostate epithelial cells.	Citric Acid	30-37	prolactin	Rattus norvegicus	0-9
2287610-8	1990	By our method, the DEAE-Sephadex step is omitted, the G6PD is eluted from P11 with citrate and NADP, and from 2"5" ADP-Sepharose with KC1, NADP and EDTA.	Citric Acid	83-90	glucose-6-phosphate dehydrogenase	Homo sapiens	54-58
2385549-4	1990	The phorbol ester TPA (12-O-tetradecanoyl-phorbol-13-acetate) induced the same effects as prolactin thereby indicating the involvement of protein kinase C. This report demonstrates that prolactin directly regulates citrate production of prostate epithelial cells and the availability of an in vitro model to elucidate the mechanism of action of prolactin.	Citric Acid	215-222	prolactin	Rattus norvegicus	90-99
2385549-1	1990	Prolactin, in vitro, significantly increased citrate production, mAAT (mitochondrial aspartate aminotransferase) and pmAAT (precursor form of mAAT) activity of prostate epithelial cells derived from rat lateral prostate (LP) and pig prostate cultures.	Citric Acid	45-52	prolactin	Rattus norvegicus	0-9
2385549-4	1990	The phorbol ester TPA (12-O-tetradecanoyl-phorbol-13-acetate) induced the same effects as prolactin thereby indicating the involvement of protein kinase C. This report demonstrates that prolactin directly regulates citrate production of prostate epithelial cells and the availability of an in vitro model to elucidate the mechanism of action of prolactin.	Citric Acid	215-222	prolactin	Rattus norvegicus	186-195
2385549-4	1990	The phorbol ester TPA (12-O-tetradecanoyl-phorbol-13-acetate) induced the same effects as prolactin thereby indicating the involvement of protein kinase C. This report demonstrates that prolactin directly regulates citrate production of prostate epithelial cells and the availability of an in vitro model to elucidate the mechanism of action of prolactin.	Citric Acid	215-222	prolactin	Rattus norvegicus	186-195
33777935-9	2021	Therefore, expedited citrate efflux from cholesterol-enriched tumor mitochondria via the CTP/SLC25A1 citrate transporter is fundamental for sustaining the constant demand for cytosolic citrate that fuels the elevated flow of carbons from acetyl-CoA through the deregulated pathway of cholesterol biosynthesis.	Citric Acid	21-28	solute carrier family 25 member 1	Homo sapiens	89-92
33821665-10	2021	Metabolomics/lipidomics, functional metabolic assays, and single-cell analysis of cultured human macrophages revealed that PPARalpha modulates macrophage glycolysis, citrate metabolism, mitochondrial membrane sphingolipid metabolism, and heterogeneity.	Citric Acid	166-173	peroxisome proliferator activated receptor alpha	Homo sapiens	123-132
33768618-5	2021	Acetate buffer was found to work better than citrate/phosphate buffer for the oxytocin stability.	Citric Acid	45-52	oxytocin/neurophysin I prepropeptide	Homo sapiens	78-86
33777935-9	2021	Therefore, expedited citrate efflux from cholesterol-enriched tumor mitochondria via the CTP/SLC25A1 citrate transporter is fundamental for sustaining the constant demand for cytosolic citrate that fuels the elevated flow of carbons from acetyl-CoA through the deregulated pathway of cholesterol biosynthesis.	Citric Acid	101-108	solute carrier family 25 member 1	Homo sapiens	89-92
33777935-9	2021	Therefore, expedited citrate efflux from cholesterol-enriched tumor mitochondria via the CTP/SLC25A1 citrate transporter is fundamental for sustaining the constant demand for cytosolic citrate that fuels the elevated flow of carbons from acetyl-CoA through the deregulated pathway of cholesterol biosynthesis.	Citric Acid	101-108	solute carrier family 25 member 1	Homo sapiens	93-100
33777935-9	2021	Therefore, expedited citrate efflux from cholesterol-enriched tumor mitochondria via the CTP/SLC25A1 citrate transporter is fundamental for sustaining the constant demand for cytosolic citrate that fuels the elevated flow of carbons from acetyl-CoA through the deregulated pathway of cholesterol biosynthesis.	Citric Acid	21-28	solute carrier family 25 member 1	Homo sapiens	93-100
27912099-7	2017	However, with the increase in citrate concentration from 0.1 to 1 mM, the As partitioned in the solution increased from 0.3 to 2.67 muM.	Citric Acid	30-37	latexin	Homo sapiens	132-135
33809182-6	2021	In addition, BACH1 suppresses activity of pyruvate dehydrogenase (PDH), a key enzyme that converts pyruvate to acetyl-CoA for the citric acid (TCA) cycle through transcriptional activation of pyruvate dehydrogenase kinase (PDK).	Citric Acid	130-141	BTB domain and CNC homolog 1	Homo sapiens	13-18
33809182-6	2021	In addition, BACH1 suppresses activity of pyruvate dehydrogenase (PDH), a key enzyme that converts pyruvate to acetyl-CoA for the citric acid (TCA) cycle through transcriptional activation of pyruvate dehydrogenase kinase (PDK).	Citric Acid	130-141	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	42-64
33809182-6	2021	In addition, BACH1 suppresses activity of pyruvate dehydrogenase (PDH), a key enzyme that converts pyruvate to acetyl-CoA for the citric acid (TCA) cycle through transcriptional activation of pyruvate dehydrogenase kinase (PDK).	Citric Acid	130-141	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	66-69
29289017-6	2018	SM1, was also able to dissimilatory reduce iron (III) and uranium (VI) in the presence of citrate as an electron donor.	Citric Acid	90-97	SM1	Homo sapiens	0-3
11519124-3	2001	Addition of 2.0 mol/l urea in 0.1 mol/l citrate buffer(pH 4.5) was effective for elimination of immunoglobulins, such as IgG and IgM, and rheumatoid factors adsorped non-specifically to liver-type arginase-autoantibody complexes on the plate.	Citric Acid	40-47	arginase 1	Homo sapiens	186-205
12812680-12	2003	CONCLUSION: NaDC3 may play a role in the aging process through the metabolic mechanism of citrate, etc.	Citric Acid	90-97	solute carrier family 13 member 3	Rattus norvegicus	12-17
34923382-5	2022	A pyrene removal rate of 90.53% was achieved in aqueous solutions and an above 80% removal rate was obtained in weakly acidic or neutral soil environments by CS-U@PS activated by Fe2+ with citric acid as the chelating agent.	Citric Acid	189-200	citrate synthase	Homo sapiens	158-160
12177002-3	2002	Here we report on the cloning and functional characterization of a plasma membrane transporter (NaCT for Na+ -coupled citrate transporter) from rat brain that mediates uphill cellular uptake of citrate coupled to an electrochemical Na+ gradient.	Citric Acid	118-125	solute carrier family 13 member 5	Rattus norvegicus	96-100
12177002-6	2002	When expressed heterologously in mammalian cells, rat NaCT mediates the transport of citrate with high affinity (Michaelis-Menten constant, approximately 20 microm) and with a Na+:citrate stoichiometry of 4:1.	Citric Acid	85-92	solute carrier family 13 member 5	Rattus norvegicus	54-58
12177002-9	2002	NaCT represents the first transporter to be identified in mammalian cells that shows preference for citrate over dicarboxylates.	Citric Acid	100-107	solute carrier family 13 member 2	Homo sapiens	0-4
34757181-7	2022	The dissolution rate decreases when: 1) citrate is consumed by the reaction with the released Al cations; 2) the pH increases during a reaction in poorly buffered solutions; 3) the dissolution products are accumulated; 4) fibers are not fully wetted with the fluid.	Citric Acid	40-47	phenylalanine hydroxylase	Homo sapiens	113-115
34738699-1	2022	In the current investigation, a series of NaCa1-x PO4 :xDy3+ (x = 0.1, 0.3, 0.5, 0.7, 1.0, 1.5 and 2 mol %) phosphors have been synthesized by solution combustion method using citric acid as fuel.	Citric Acid	176-187	nascent polypeptide associated complex subunit alpha	Homo sapiens	42-47
34342829-1	2022	A composite material prepared by polymerization of beta-cyclodextrin (beta-CD) on the surface of natural hydroxyapatite using citric acid as cross linker, was employed as electrode material for the detection of Pb(II).	Citric Acid	126-137	ACD shelterin complex subunit and telomerase recruitment factor	Bos taurus	70-77
34747157-5	2022	Furthermore, ATM-associated DNA damage response cooperates with MAPK and mTOR signaling pathways to control citrate-induced tumor cell growth arrest and senescence.	Citric Acid	108-115	ATM serine/threonine kinase	Homo sapiens	13-16
34747157-5	2022	Furthermore, ATM-associated DNA damage response cooperates with MAPK and mTOR signaling pathways to control citrate-induced tumor cell growth arrest and senescence.	Citric Acid	108-115	mechanistic target of rapamycin kinase	Homo sapiens	73-77
34619358-1	2022	Malate dehydrogenase (MDH) catalyzes the conversion of NAD+ and malate to NADH and oxaloacetate in the citric acid cycle.	Citric Acid	103-114	Malate dehydrogenase	Caenorhabditis elegans	0-20
34619358-1	2022	Malate dehydrogenase (MDH) catalyzes the conversion of NAD+ and malate to NADH and oxaloacetate in the citric acid cycle.	Citric Acid	103-114	Malate dehydrogenase	Caenorhabditis elegans	22-25
34662447-11	2022	CONCLUSIONS: The aqueous metabolomic patterns in Pten-KO prostate and TRAMP NECa shared similarities in the greater pools of cystathionine, GSH/GSSG redox pair, and nucleotides and shunting away from glycolysis-citrate cycle in both models.	Citric Acid	211-218	phosphatase and tensin homolog	Mus musculus	49-53
34662447-11	2022	CONCLUSIONS: The aqueous metabolomic patterns in Pten-KO prostate and TRAMP NECa shared similarities in the greater pools of cystathionine, GSH/GSSG redox pair, and nucleotides and shunting away from glycolysis-citrate cycle in both models.	Citric Acid	211-218	dermatopontin	Mus musculus	70-75
34928443-7	2021	Malate, fumarate, pyruvate, alpha-ketoglutarate, lactate, succinate and citrate/isocitrate loaded positively on PC1; methylsuccinate, ethylmalonate and succinate loaded positively on PC2; and methylmalonate, ethylmalonate and citrate/isocitrate loaded negatively on PC3.	Citric Acid	72-79	proprotein convertase subtilisin/kexin type 1	Homo sapiens	112-115
34939235-8	2022	However, downregulation of triglyceride and citric acid was only observed in SLC25A17 silenced cells.	Citric Acid	44-55	solute carrier family 25 member 17	Homo sapiens	77-85
34919194-7	2021	The addition of bovine serum albumin (BSA), as an index protein, substantially further decreased the T2 of spermine and citrate implying the formation of a transient spermine-metal ion-citrate-BSA complex.	Citric Acid	120-127	albumin	Homo sapiens	23-36
34927252-9	2021	CONCLUSION: Citric acid was proved as an effective dissolving and crosslinking agents simultaneously in the preparation of MCS and HCS based hydrogels.	Citric Acid	12-23	holocarboxylase synthetase	Homo sapiens	131-134
34919194-7	2021	The addition of bovine serum albumin (BSA), as an index protein, substantially further decreased the T2 of spermine and citrate implying the formation of a transient spermine-metal ion-citrate-BSA complex.	Citric Acid	185-192	albumin	Homo sapiens	23-36
34946101-6	2021	Exogenous citric acid treatment boosted plant growth and development by improving photosynthesis via enzymes such as superoxide dismutase, guaiacol peroxidase, catalase, and ascorbate peroxidase, which decreased Cr toxicity.	Citric Acid	10-21	LOW QUALITY PROTEIN: peroxidase 60	Ricinus communis	148-158
34498076-3	2021	Here we show by a systems approach that DICARBOXYLATE CARRIER 2 (DIC2) facilitates mitochondrial malate-citrate exchange in vivo in Arabidopsis thaliana.	Citric Acid	104-111	dicarboxylate carrier 2	Arabidopsis thaliana	40-63
34498076-3	2021	Here we show by a systems approach that DICARBOXYLATE CARRIER 2 (DIC2) facilitates mitochondrial malate-citrate exchange in vivo in Arabidopsis thaliana.	Citric Acid	104-111	dicarboxylate carrier 2	Arabidopsis thaliana	65-69
34498076-5	2021	In vitro and in organello analyses demonstrate that DIC2 preferentially imports malate against citrate export, which is consistent with altered malate and citrate utilisation in response to prolonged darkness of dic2-1 plants or a sudden shift to darkness of dic2-1 leaves.	Citric Acid	95-102	dicarboxylate carrier 2	Arabidopsis thaliana	212-216
34498076-5	2021	In vitro and in organello analyses demonstrate that DIC2 preferentially imports malate against citrate export, which is consistent with altered malate and citrate utilisation in response to prolonged darkness of dic2-1 plants or a sudden shift to darkness of dic2-1 leaves.	Citric Acid	95-102	dicarboxylate carrier 2	Arabidopsis thaliana	259-263
34498076-5	2021	In vitro and in organello analyses demonstrate that DIC2 preferentially imports malate against citrate export, which is consistent with altered malate and citrate utilisation in response to prolonged darkness of dic2-1 plants or a sudden shift to darkness of dic2-1 leaves.	Citric Acid	155-162	dicarboxylate carrier 2	Arabidopsis thaliana	52-56
34498076-5	2021	In vitro and in organello analyses demonstrate that DIC2 preferentially imports malate against citrate export, which is consistent with altered malate and citrate utilisation in response to prolonged darkness of dic2-1 plants or a sudden shift to darkness of dic2-1 leaves.	Citric Acid	155-162	dicarboxylate carrier 2	Arabidopsis thaliana	212-216
34498076-5	2021	In vitro and in organello analyses demonstrate that DIC2 preferentially imports malate against citrate export, which is consistent with altered malate and citrate utilisation in response to prolonged darkness of dic2-1 plants or a sudden shift to darkness of dic2-1 leaves.	Citric Acid	155-162	dicarboxylate carrier 2	Arabidopsis thaliana	259-263
34498076-7	2021	These observations reveal the physiological function of DIC2 in mediating the flow of malate and citrate between the mitochondrial matrix and other cell compartments.	Citric Acid	97-104	dicarboxylate carrier 2	Arabidopsis thaliana	56-60
34839601-13	2021	Urea nitrogen level, creatinine level, and CRP value of patients in citrate group were significantly lower than those in heparin group (P<0.05).	Citric Acid	68-75	C-reactive protein	Homo sapiens	43-46
34895160-1	2021	BACKGROUND: Regional citrate anticoagulation may cause a negative calcium balance, systemic hypocalcemia and parathormone (PTH) activation but randomzed studies are not available.	Citric Acid	21-28	parathyroid hormone	Homo sapiens	123-126
34796899-8	2021	In addition, we solved an ODC/PLP complex structure with citrate bound at the substrate binding pocket.	Citric Acid	57-64	ornithine decarboxylase 1	Homo sapiens	26-29
34946101-6	2021	Exogenous citric acid treatment boosted plant growth and development by improving photosynthesis via enzymes such as superoxide dismutase, guaiacol peroxidase, catalase, and ascorbate peroxidase, which decreased Cr toxicity.	Citric Acid	10-21	catalase isozyme 1-like	Ricinus communis	160-168
34946101-6	2021	Exogenous citric acid treatment boosted plant growth and development by improving photosynthesis via enzymes such as superoxide dismutase, guaiacol peroxidase, catalase, and ascorbate peroxidase, which decreased Cr toxicity.	Citric Acid	10-21	LOW QUALITY PROTEIN: peroxidase 60	Ricinus communis	184-194
34609626-5	2021	Enzymatic activities (lactate dehydrogenase and beta-galactosidase) of L90, and its metabolism of lactose and citric acid, as well as lactic acid and pyruvic acid production in milk, were modified depending on the growth media.	Citric Acid	110-121	beta-galactosidase	Glycine max	48-66
34924279-10	2021	Here, we suggest that this could be achieved by citrate administration at high concentration, because citrate is a physiologic inhibitor of PFK1 and PFK2.	Citric Acid	48-55	phosphofructokinase, muscle	Homo sapiens	140-144
34924279-10	2021	Here, we suggest that this could be achieved by citrate administration at high concentration, because citrate is a physiologic inhibitor of PFK1 and PFK2.	Citric Acid	48-55	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	149-153
34924279-10	2021	Here, we suggest that this could be achieved by citrate administration at high concentration, because citrate is a physiologic inhibitor of PFK1 and PFK2.	Citric Acid	102-109	phosphofructokinase, muscle	Homo sapiens	140-144
34924279-10	2021	Here, we suggest that this could be achieved by citrate administration at high concentration, because citrate is a physiologic inhibitor of PFK1 and PFK2.	Citric Acid	102-109	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	149-153
34924279-11	2021	As shown in various in vitro studies, including HCC cell lines, administration of high concentrations of citrate inhibits PFK1 and PFK2 (and consequently glycolysis), decreases ATP production, counteracts HIF-1alpha and PI3K/AKT signaling, induces apoptosis, and sensitizes cells to cisplatin treatment.	Citric Acid	105-112	phosphofructokinase, muscle	Homo sapiens	122-126
34924279-11	2021	As shown in various in vitro studies, including HCC cell lines, administration of high concentrations of citrate inhibits PFK1 and PFK2 (and consequently glycolysis), decreases ATP production, counteracts HIF-1alpha and PI3K/AKT signaling, induces apoptosis, and sensitizes cells to cisplatin treatment.	Citric Acid	105-112	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	131-135
34924279-11	2021	As shown in various in vitro studies, including HCC cell lines, administration of high concentrations of citrate inhibits PFK1 and PFK2 (and consequently glycolysis), decreases ATP production, counteracts HIF-1alpha and PI3K/AKT signaling, induces apoptosis, and sensitizes cells to cisplatin treatment.	Citric Acid	105-112	hypoxia inducible factor 1 subunit alpha	Homo sapiens	205-215
34924279-11	2021	As shown in various in vitro studies, including HCC cell lines, administration of high concentrations of citrate inhibits PFK1 and PFK2 (and consequently glycolysis), decreases ATP production, counteracts HIF-1alpha and PI3K/AKT signaling, induces apoptosis, and sensitizes cells to cisplatin treatment.	Citric Acid	105-112	AKT serine/threonine kinase 1	Homo sapiens	225-228
34899913-9	2021	Z350 and HRI showed higher microhardness percentage loss, and it was more evident after storage in alcohol (-48.49 +- 20.16 and -25.02 +- 14.04, respectively) and citric acid (-65.05 +- 28.97 and 16.12 +- 8.35, respectively).	Citric Acid	163-174	eukaryotic translation initiation factor 2 alpha kinase 1	Homo sapiens	9-12
34810128-5	2021	Our findings demonstrated that extracellular citrate aggravated the pathological lung injury induced by LPS in mice, characterized by up-regulation of pro-inflammatory factors and over-activation of NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome in the lungs.	Citric Acid	45-52	NLR family, pyrin domain containing 3	Mus musculus	199-247
34810128-5	2021	Our findings demonstrated that extracellular citrate aggravated the pathological lung injury induced by LPS in mice, characterized by up-regulation of pro-inflammatory factors and over-activation of NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome in the lungs.	Citric Acid	45-52	NLR family, pyrin domain containing 3	Mus musculus	249-254
34810128-6	2021	In vitro, we found that citrate treatment significantly augmented the expression of NLRP3 and pro-IL-1beta and enhanced the translocation of NF-kappaB/p65 into the nucleus.	Citric Acid	24-31	NLR family, pyrin domain containing 3	Mus musculus	84-89
34810128-6	2021	In vitro, we found that citrate treatment significantly augmented the expression of NLRP3 and pro-IL-1beta and enhanced the translocation of NF-kappaB/p65 into the nucleus.	Citric Acid	24-31	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	141-151
34810128-6	2021	In vitro, we found that citrate treatment significantly augmented the expression of NLRP3 and pro-IL-1beta and enhanced the translocation of NF-kappaB/p65 into the nucleus.	Citric Acid	24-31	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	151-154
34810128-9	2021	Altogether, we conclude that extracellular citrate may serve as a damage-associated molecular pattern (DAMP) and aggravates LPS-induced ALI by activating the NLRP3 inflammasome.	Citric Acid	43-50	NLR family, pyrin domain containing 3	Mus musculus	158-163
34943889-2	2021	The solute carrier family 13 member 5 (SLC13A5), a sodium-coupled citrate transporter, plays an important role in intracellular citrate homeostasis that is associated with a number of metabolic syndromes and neurological disorders.	Citric Acid	128-135	solute carrier family 13 member 5	Homo sapiens	4-37
34943889-2	2021	The solute carrier family 13 member 5 (SLC13A5), a sodium-coupled citrate transporter, plays an important role in intracellular citrate homeostasis that is associated with a number of metabolic syndromes and neurological disorders.	Citric Acid	128-135	solute carrier family 13 member 5	Homo sapiens	39-46
34899913-11	2021	HRI had the worst roughness for citric acid (-0.090 +- 0.025).	Citric Acid	32-43	eukaryotic translation initiation factor 2 alpha kinase 1	Homo sapiens	0-3
34371126-7	2021	Citrate supplemented animals had increased liver PKCalpha activity and altered phosphorylation at serine or threonine residues of components of insulin signaling including IRS-1, Akt, GSK-3 and FoxO1.	Citric Acid	0-7	protein kinase C, alpha	Mus musculus	49-57
34371126-7	2021	Citrate supplemented animals had increased liver PKCalpha activity and altered phosphorylation at serine or threonine residues of components of insulin signaling including IRS-1, Akt, GSK-3 and FoxO1.	Citric Acid	0-7	insulin receptor substrate 1	Mus musculus	172-177
34371126-7	2021	Citrate supplemented animals had increased liver PKCalpha activity and altered phosphorylation at serine or threonine residues of components of insulin signaling including IRS-1, Akt, GSK-3 and FoxO1.	Citric Acid	0-7	thymoma viral proto-oncogene 1	Mus musculus	179-182
34371126-7	2021	Citrate supplemented animals had increased liver PKCalpha activity and altered phosphorylation at serine or threonine residues of components of insulin signaling including IRS-1, Akt, GSK-3 and FoxO1.	Citric Acid	0-7	glycogen synthase kinase 3 beta	Mus musculus	184-189
34371126-7	2021	Citrate supplemented animals had increased liver PKCalpha activity and altered phosphorylation at serine or threonine residues of components of insulin signaling including IRS-1, Akt, GSK-3 and FoxO1.	Citric Acid	0-7	forkhead box O1	Mus musculus	194-199
34839347-2	2021	The mitochondrial citrate carrier SLC25A1 (also known as mitochondrial citrate/isocitrate carrier, CIC), has been shown to play an important role in lipid metabolism regulation.	Citric Acid	18-25	solute carrier family 25 member 1	Homo sapiens	34-41
34839347-2	2021	The mitochondrial citrate carrier SLC25A1 (also known as mitochondrial citrate/isocitrate carrier, CIC), has been shown to play an important role in lipid metabolism regulation.	Citric Acid	71-78	solute carrier family 25 member 1	Homo sapiens	34-41
34732847-9	2022	Enzymes for ketone body catabolism (Scot) and citrate cycle (Cs, Idh3a), and a marker of regenerating muscle (myogenin) were also upregulated via increased KLB expression.	Citric Acid	46-53	klotho beta	Mus musculus	156-159
34795200-6	2021	Unfortunately, increases in matrix metalloproteinase 9, tumor necrosis factor alpha, and interleukin-1 were detected in the product after incubation; however, these increases could be blocked by adding citric acid, with no effect on the concentration of the target therapeutic molecules.	Citric Acid	202-213	matrix metallopeptidase 9	Homo sapiens	28-54
34795200-6	2021	Unfortunately, increases in matrix metalloproteinase 9, tumor necrosis factor alpha, and interleukin-1 were detected in the product after incubation; however, these increases could be blocked by adding citric acid, with no effect on the concentration of the target therapeutic molecules.	Citric Acid	202-213	tumor necrosis factor	Homo sapiens	56-83
34795200-6	2021	Unfortunately, increases in matrix metalloproteinase 9, tumor necrosis factor alpha, and interleukin-1 were detected in the product after incubation; however, these increases could be blocked by adding citric acid, with no effect on the concentration of the target therapeutic molecules.	Citric Acid	202-213	interleukin 1 alpha	Homo sapiens	89-102
34492283-8	2021	Furthermore, cell treatment with citric acid was found to reduce inflammation in a lipopolysaccharide (LPS)-induced in vitro inflammation model by significantly reducing interleukin 6 expression.	Citric Acid	33-44	interleukin 6	Homo sapiens	170-183
34119736-3	2021	The citrate iron complex of Fe(II)(Cit)- played the key role for the degradation process since it could quickly react with the generated H2O2 to produce free radicals in the Bi/Fe0+NaCA + CA system, which broadened the applicable pH range of the traditional Fenton reaction and promoted the oxidative degradation process of ATR.	Citric Acid	4-11	nascent polypeptide associated complex subunit alpha	Homo sapiens	181-185
34458928-7	2021	Na+-dependent dicarboxylate-1 (NADC-1) is the Na+-carboxylate co-transporter of the SLC13 gene family, which primarily mediates the co-transport of Na+ and tricarboxylic acid cycle intermediates, such as citrate and succinate, amongst others.	Citric Acid	204-211	solute carrier family 13 member 2	Homo sapiens	0-29
34458928-11	2021	The present review examines the results from early reports studying oxalate transport and citrate transport in the kidney, describing the synergistic molecular mechanisms of SLC26A6 and NADC-1 in the process of nephrolithiasis formation.	Citric Acid	90-97	solute carrier family 26 member 6	Homo sapiens	174-181
34458928-7	2021	Na+-dependent dicarboxylate-1 (NADC-1) is the Na+-carboxylate co-transporter of the SLC13 gene family, which primarily mediates the co-transport of Na+ and tricarboxylic acid cycle intermediates, such as citrate and succinate, amongst others.	Citric Acid	204-211	solute carrier family 13 member 2	Homo sapiens	31-37
34537657-2	2021	C18-CDs are synthesized by simple one-step solvothermal method using octadecylamine and citric acid as carbon sources, and C18-CDs with proper polarity are collected through column chromatography purification.	Citric Acid	88-99	Bardet-Biedl syndrome 9	Homo sapiens	0-3
34831186-3	2021	In this context, the metabolic enzyme ATP citrate lyase (ACLY), the producer of citrate-derived acetyl-coenzyme A (CoA), plays a critical role in supporting a proinflammatory response.	Citric Acid	80-87	ATP citrate lyase	Homo sapiens	38-55
34714823-5	2021	In fact, glutamate biosynthesis from the citric acid cycle was limiting in Indy mutants for seizure-suppressing glutamate transmission.	Citric Acid	41-52	I'm not dead yet	Drosophila melanogaster	75-79
34831186-3	2021	In this context, the metabolic enzyme ATP citrate lyase (ACLY), the producer of citrate-derived acetyl-coenzyme A (CoA), plays a critical role in supporting a proinflammatory response.	Citric Acid	80-87	ATP citrate lyase	Homo sapiens	57-61
34746707-4	2021	The HFD activated ACLY to govern the "citrate transport" to transfer acetyl-CoA from the mitochondria to the nucleus.	Citric Acid	38-45	ATP-citrate synthase	Larimichthys crocea	18-22
34677421-8	2021	Indy gene expression levels change in response to caloric content of the diet, inflammation and aging, suggesting that INDY regulates metabolic adaptation to nutrition or energetic requirements by controlling citrate levels.	Citric Acid	209-216	I'm not dead yet	Drosophila melanogaster	0-4
34677421-8	2021	Indy gene expression levels change in response to caloric content of the diet, inflammation and aging, suggesting that INDY regulates metabolic adaptation to nutrition or energetic requirements by controlling citrate levels.	Citric Acid	209-216	I'm not dead yet	Drosophila melanogaster	119-123
34491056-7	2021	As a test application we show that, during the interaction between a single CNP and a flat planar 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine bilayer, the citrate coating is spontaneously replaced by lipids on the surface of Au NPs, while the NP size and shape determine the final structural configuration of the NP-bilayer complex.	Citric Acid	160-167	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	76-79
34677420-2	2021	The solute carrier family 13 member 5 (SLC13A5), a sodium-coupled citrate transporter highly expressed in the mammalian liver with relatively low levels in the testis and brain, imports citrate from extracellular spaces into the cells.	Citric Acid	186-193	solute carrier family 13 member 5	Homo sapiens	4-37
34677420-2	2021	The solute carrier family 13 member 5 (SLC13A5), a sodium-coupled citrate transporter highly expressed in the mammalian liver with relatively low levels in the testis and brain, imports citrate from extracellular spaces into the cells.	Citric Acid	186-193	solute carrier family 13 member 5	Homo sapiens	39-46
34677421-3	2021	Indy reduction in flies, worms, mice and rats affects metabolism by regulating the levels of cytoplasmic citrate, inducing a state similar to calorie restriction.	Citric Acid	105-112	I'm not dead yet	Drosophila melanogaster	0-4
34632918-4	2021	Consistently, FLT4 mutants lacking the extracellular ligand-binding domain increased production of the proinflammatory metabolites such as succinate and lactate, and reduced antimicrobial metabolites including citrate and NAD(P)H in macrophages and liver upon infection.	Citric Acid	210-217	fms related receptor tyrosine kinase 4	Homo sapiens	14-18
34352515-7	2021	Thus, we propose that PEPCK1 contributes to citrate degradation under nitrogen limitation.	Citric Acid	44-51	phosphoenolpyruvate carboxykinase 1	Homo sapiens	22-28
34640224-8	2021	ELISA assays showed higher TGF-beta1 release from 10% EDTA compared to 10% citric acid (p < 0.00001).	Citric Acid	75-86	transforming growth factor beta 1	Homo sapiens	27-36
34677384-1	2021	INDY (I"m Not Dead Yet) is a plasma membrane transporter for citrate, first identified in Drosophila.	Citric Acid	61-68	I'm not dead yet	Drosophila melanogaster	0-4
34482919-2	2021	The Al-dependent release of citrate from resistant lines of maize is controlled by ZmMATE1 which encodes a multidrug and toxic compound extrusion (MATE) transporter protein.	Citric Acid	28-35	Protein DETOXIFICATION 42	Zea mays	83-90
34650548-8	2021	These findings suggest increased glycolysis, perturbation in the citrate cycle, oxidative stress, protein catabolism and increased urea cycle activity are key characteristics of newly presenting RA patients with elevated CRP.	Citric Acid	65-72	C-reactive protein	Homo sapiens	221-224
34677384-1	2021	INDY (I"m Not Dead Yet) is a plasma membrane transporter for citrate, first identified in Drosophila.	Citric Acid	61-68	I'm not dead yet	Drosophila melanogaster	6-22
34677384-3	2021	The mammalian counterpart (NaCT/SLC13A5) also transports citrate.	Citric Acid	57-64	solute carrier family 13 member 5	Homo sapiens	27-31
34677384-3	2021	The mammalian counterpart (NaCT/SLC13A5) also transports citrate.	Citric Acid	57-64	solute carrier family 13 member 5	Homo sapiens	32-39
34677384-6	2021	Though both Drosophila INDY and mammalian INDY transport citrate, the translocation mechanism differs, the former being a dicarboxylate exchanger for the influx of citrate2- in exchange for other dicarboxylates, and the latter being a Na+-coupled uniporter for citrate2-.	Citric Acid	57-64	I'm not dead yet	Drosophila melanogaster	42-46
34548590-3	2021	Microscale Thermophoresis analysis of the porcine heart MDH-CS complex revealed that substrates of the MDH and CS reactions, NAD+ and acetyl-CoA, enhance complex association while products of the reactions, NADH and citrate, weaken the affinity of the complex.	Citric Acid	216-223	citrate synthase	Homo sapiens	60-62
34525352-0	2021	NaCT/SLC13A5 facilitates citrate import and metabolism under nutrient-limited conditions.	Citric Acid	25-32	solute carrier family 13 member 5	Homo sapiens	0-4
34538237-3	2021	RESULTS: RALA/Au nanoparticles were formed by optimising the ratio of RALA to citrate capped AuNPs, with assembly occurring through electrostatic interactions.	Citric Acid	78-85	RAS like proto-oncogene A	Homo sapiens	9-13
34525352-0	2021	NaCT/SLC13A5 facilitates citrate import and metabolism under nutrient-limited conditions.	Citric Acid	25-32	solute carrier family 13 member 5	Homo sapiens	5-12
34525352-3	2021	To examine how NaCT contributes to citrate metabolism in cells relevant to the pathophysiology of these diseases, we apply 13C isotope tracing to SLC13A5-deficient hepatocellular carcinoma (HCC) cells and primary rat cortical neurons.	Citric Acid	35-42	solute carrier family 13 member 5	Rattus norvegicus	15-19
34525352-6	2021	Knockout of SLC13A5 in Huh7 cells compromises citrate uptake and catabolism.	Citric Acid	46-53	solute carrier family 13 member 5	Homo sapiens	12-19
34525352-8	2021	Collectively, these findings demonstrate that NaCT-mediated citrate uptake is metabolically important under nutrient-limited conditions and may facilitate resistance to metal toxicity.	Citric Acid	60-67	solute carrier family 13 member 5	Homo sapiens	46-50
34495967-6	2021	All GABA pathway metabolites (gamma-hydroxybutyrate, glutamine, glutamate, total GABA, succinic semialdehyde) and TCA cycle metabolites (citrate, malate, fumarate, isocitrate, lactate) were significantly low in the homozygous knock-out aldh7a1 zebrafish compared to the wildtype zebrafish.	Citric Acid	137-144	aldehyde dehydrogenase 7 family, member A1	Danio rerio	236-243
34242566-7	2021	FOXA1 knockout partially reversed the changes of ENO2, SDHA, PCK2 and p-ERK1/2 (Thr202/Tyr204) levels, lactic acid release, citric acid content in mitochondria of THBEc1 cells.	Citric Acid	124-135	forkhead box A1	Homo sapiens	0-5
34512869-7	2021	Results: Multiomic analysis revealed that PKLR perturbations significantly affected the pyruvate, citrate, and glycerophospholipid metabolism pathways, as crucial steps in de novo lipogenesis (DNL).	Citric Acid	98-105	pyruvate kinase L/R	Homo sapiens	42-46
34488769-14	2021	Further analysis of the biological interaction and gene regulation networks of LYRM4 suggested that these genes were mainly involved in the citric acid cycle and oxidative phosphorylation.	Citric Acid	140-151	LYR motif containing 4	Homo sapiens	79-84
34502217-6	2021	Interestingly, combined overexpression of either hexokinase with hexose transporters significantly accelerated citric acid biosynthesis and enhanced pentose phosphate pathway leading to secretion of polyols (31.5 g/L vs. no polyols in the control strain).	Citric Acid	111-122	hexokinase	Saccharomyces cerevisiae S288C	49-59
34391608-3	2021	In a previous work, we described the acute changes during an HD session with a DF with citrate instead of acetate.	Citric Acid	87-94	complement factor D	Homo sapiens	79-81
34443969-5	2021	Lysozyme-AuNPs interactions induce aggregation of citrate-stabilized AuNPs at low concentrations by neutering the negative charges of citrate anions; from those aggregation data, the magnitude of the interactions has been measured by using Benesi-Hildebrand plots.	Citric Acid	50-57	lysozyme	Homo sapiens	0-8
34443969-5	2021	Lysozyme-AuNPs interactions induce aggregation of citrate-stabilized AuNPs at low concentrations by neutering the negative charges of citrate anions; from those aggregation data, the magnitude of the interactions has been measured by using Benesi-Hildebrand plots.	Citric Acid	134-141	lysozyme	Homo sapiens	0-8
34440217-8	2021	However, many of the interactors were involved in the ER to Golgi anterograde transport (e.g., AP3D1), aggrephagy (e.g., PSMC1), and the pyruvate metabolism/citric acid cycle (e.g., SHMT2), and illustrated the complex protein interaction networks of HTRA2 in neurological tissues.	Citric Acid	157-168	HtrA serine peptidase 2	Sus scrofa	250-255
34456857-9	2021	Estrogens altered the levels of metabolites from various pathways, including aerobic glycolysis, citric acid cycle, urea cycle, and amino acid metabolism, demonstrating that ERalpha reprograms cell metabolism in mammary organoids.	Citric Acid	97-108	estrogen receptor 1 (alpha)	Mus musculus	174-181
34323067-0	2021	Regulation on Citrate Influx and Metabolism through Inhibiting SLC13A5 and ACLY: A Novel Mechanism Mediating the Therapeutic Effects of Curcumin on NAFLD.	Citric Acid	14-21	solute carrier family 13 member 5	Homo sapiens	63-70
34323067-0	2021	Regulation on Citrate Influx and Metabolism through Inhibiting SLC13A5 and ACLY: A Novel Mechanism Mediating the Therapeutic Effects of Curcumin on NAFLD.	Citric Acid	14-21	ATP citrate lyase	Homo sapiens	75-79
34323067-2	2021	Cytoplasmic citrate flux, mediated by plasma membrane citrate transporter (SLC13A5), mitochondrial citrate carrier (SLC25A1), and ATP-dependent citrate lyase (ACLY), determines the central carbon source for acetyl-CoA required in DNL.	Citric Acid	12-19	solute carrier family 13 member 5	Homo sapiens	75-82
34323067-2	2021	Cytoplasmic citrate flux, mediated by plasma membrane citrate transporter (SLC13A5), mitochondrial citrate carrier (SLC25A1), and ATP-dependent citrate lyase (ACLY), determines the central carbon source for acetyl-CoA required in DNL.	Citric Acid	12-19	solute carrier family 25 member 1	Homo sapiens	116-123
34323067-2	2021	Cytoplasmic citrate flux, mediated by plasma membrane citrate transporter (SLC13A5), mitochondrial citrate carrier (SLC25A1), and ATP-dependent citrate lyase (ACLY), determines the central carbon source for acetyl-CoA required in DNL.	Citric Acid	12-19	ATP citrate lyase	Homo sapiens	130-157
34323067-2	2021	Cytoplasmic citrate flux, mediated by plasma membrane citrate transporter (SLC13A5), mitochondrial citrate carrier (SLC25A1), and ATP-dependent citrate lyase (ACLY), determines the central carbon source for acetyl-CoA required in DNL.	Citric Acid	12-19	ATP citrate lyase	Homo sapiens	159-163
34323067-2	2021	Cytoplasmic citrate flux, mediated by plasma membrane citrate transporter (SLC13A5), mitochondrial citrate carrier (SLC25A1), and ATP-dependent citrate lyase (ACLY), determines the central carbon source for acetyl-CoA required in DNL.	Citric Acid	99-106	solute carrier family 25 member 1	Homo sapiens	116-123
34323067-8	2021	Besides, curcumin also functionally inhibited both citrate transport and metabolism mediated by SLC13A5 and ACLY, respectively.	Citric Acid	51-58	solute carrier family 13 member 5	Homo sapiens	96-103
34323067-8	2021	Besides, curcumin also functionally inhibited both citrate transport and metabolism mediated by SLC13A5 and ACLY, respectively.	Citric Acid	51-58	ATP citrate lyase	Homo sapiens	108-112
34391608-8	2021	After 16 weeks of citrate treatment, pre-HD ionic calcium and magnesium were significantly lower and paratiroid hormone (PTH) higher than in the acetate period.	Citric Acid	18-25	parathyroid hormone	Homo sapiens	121-124
34129733-6	2021	The partitioning behavior of porcine parvovirus (PPV), a nonenveloped mammalian virus, and human immunodeficiency virus-like particle (HIV-VLP), a yeast-expressed enveloped VLP, were studied in a polyethylene glycol (PEG) 12 kDa-citrate system.	Citric Acid	229-236	VHL like	Homo sapiens	139-142
34351836-7	2021	The effective molecular interactions of coumarin, citric acid, ascorbic acid, and sodium sulfide with GST target enzyme were found with their binding lowest energy affinities -4.62, -3.04, -2.53, and -1.67 kcal/mol, respectively.Communicated by Ramaswamy H. Sarma.	Citric Acid	50-61	glutathione S-transferase kappa 1	Homo sapiens	102-105
34129733-6	2021	The partitioning behavior of porcine parvovirus (PPV), a nonenveloped mammalian virus, and human immunodeficiency virus-like particle (HIV-VLP), a yeast-expressed enveloped VLP, were studied in a polyethylene glycol (PEG) 12 kDa-citrate system.	Citric Acid	229-236	VHL like	Homo sapiens	173-176
34186087-3	2021	Citrate synthase (CS) is one of only two irreversible steps in the citric acid cycle (CAC) and forms an important regulatory checkpoint that gates the entry of acetyl-CoA formed in glycolysis or fatty acid catabolism into this critical central metabolic hub.	Citric Acid	67-78	citrate synthase	Homo sapiens	0-16
34356864-2	2021	IDH enzymes catalyze the conversion of isocitrate to alpha-ketoglutarate (alpha-KG), an intermediate in the citric acid cycle.	Citric Acid	108-119	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-3
34279821-8	2022	Urinary citrate was correlated with serum creatinine (r = - 0.61, p < 0.001) and eGFR (r = 0.55, p < 0.001) in both gender.	Citric Acid	8-15	epidermal growth factor receptor	Homo sapiens	81-85
34190286-3	2021	Herein we report a versatile method for introducing functionality to gold nanoparticles by exploiting the strong interaction between chemically functionalised bovine serum albumin (f-BSA) and citrate-capped gold nanoparticles (AuNPs).	Citric Acid	192-199	albumin	Homo sapiens	166-179
34277562-1	2021	Herein, selenium and nitrogen co-doped carbon quantum dots (Se/N-CQDs) were hydrothermally synthesized by using citric acid, histidine, and sodium selenite, which had sp3 and sp2 hybridized carbon atoms and showed excitation-dependent fluorescence behavior.	Citric Acid	112-123	Sp3 transcription factor	Homo sapiens	167-170
34277562-1	2021	Herein, selenium and nitrogen co-doped carbon quantum dots (Se/N-CQDs) were hydrothermally synthesized by using citric acid, histidine, and sodium selenite, which had sp3 and sp2 hybridized carbon atoms and showed excitation-dependent fluorescence behavior.	Citric Acid	112-123	Sp2 transcription factor	Homo sapiens	175-178
34231328-1	2021	BACKGROUND: Animal models have demonstrated an interactive relationship between the epithelial anion exchanger SLC26A6 and transporter NaDC-1 that regulates citrate and oxalate homeostasis.	Citric Acid	157-164	solute carrier family 26 member 6	Homo sapiens	111-118
34231328-1	2021	BACKGROUND: Animal models have demonstrated an interactive relationship between the epithelial anion exchanger SLC26A6 and transporter NaDC-1 that regulates citrate and oxalate homeostasis.	Citric Acid	157-164	solute carrier family 13 member 2	Homo sapiens	135-141
34184985-4	2021	Herein, we report that citrate induces a phase transition that enhances SARM1 activity by ~2000-fold.	Citric Acid	23-30	sterile alpha and HEAT/Armadillo motif containing 1	Mus musculus	72-77
34184985-7	2021	We further show that citrate induces axonal degeneration in C. elegans that is dependent on the C. elegans orthologue of SARM1 (TIR-1).	Citric Acid	21-28	sterile alpha and HEAT/Armadillo motif containing 1	Mus musculus	121-126
34184985-7	2021	We further show that citrate induces axonal degeneration in C. elegans that is dependent on the C. elegans orthologue of SARM1 (TIR-1).	Citric Acid	21-28	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase;NAD(+) hydrolase tir-1	Caenorhabditis elegans	128-133
34184985-8	2021	Notably, citrate induces the formation of larger puncta indicating that TIR-1/SARM1 multimerization is essential for degeneration in vivo.	Citric Acid	9-16	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase;NAD(+) hydrolase tir-1	Caenorhabditis elegans	72-77
34184985-8	2021	Notably, citrate induces the formation of larger puncta indicating that TIR-1/SARM1 multimerization is essential for degeneration in vivo.	Citric Acid	9-16	sterile alpha and HEAT/Armadillo motif containing 1	Mus musculus	78-83
34195210-0	2021	Thrombin Generation and Platelet Function in ICU Patients Undergoing CVVHD Using Regional Citrate Anticoagulation.	Citric Acid	90-97	coagulation factor II, thrombin	Homo sapiens	0-8
34205414-8	2021	Remarkably, in preclinical cancer models, the administration of high doses of citrate showed various anti-cancer effects, such as the inhibition of glycolysis, the promotion of cytotoxic drugs sensibility and apoptosis, the neutralization of extracellular acidity, and the inhibition of tumors growth and of key signalling pathways (in particular, the IGF-1R/AKT pathway).	Citric Acid	78-85	insulin like growth factor 1 receptor	Homo sapiens	352-358
34205414-8	2021	Remarkably, in preclinical cancer models, the administration of high doses of citrate showed various anti-cancer effects, such as the inhibition of glycolysis, the promotion of cytotoxic drugs sensibility and apoptosis, the neutralization of extracellular acidity, and the inhibition of tumors growth and of key signalling pathways (in particular, the IGF-1R/AKT pathway).	Citric Acid	78-85	AKT serine/threonine kinase 1	Homo sapiens	359-362
34306426-3	2021	RESULTS: The urine oxalic acid content of the experimental group was found to be notably higher than the control group, while the citric acid content was lower; we observed higher levels of the 24-hour urine calcium content in the experimental group, while the citric acid/calcium ratio was remarkably lower; 24-hour urine magnesium and phosphorus levels of the two groups showed no marked difference; the mRNA expression levels of TRPV5 and OPN in the kidney tissues of the two groups were statistically different.	Citric Acid	130-141	transient receptor potential cation channel subfamily V member 5	Homo sapiens	432-437
34179093-2	2021	The free energy of lysozyme interacting with two kinds of polyanionic excipients, citrate and tripolyphosphate, together with sodium chloride and TRIS-buffer, are analysed in multiple-walker metadynamics simulations to understand why tripolyphosphate causes lysozyme to precipitate but citrate does not.	Citric Acid	82-89	lysozyme	Homo sapiens	19-27
34113573-2	2021	It is known to be caused by germline mutations of the fumarate hydratase (FH) gene, which encodes an enzyme component of the citric acid cycle and catalyzes the conversion of fumarate to L-malate.	Citric Acid	125-136	fumarate hydratase	Homo sapiens	54-72
34113573-2	2021	It is known to be caused by germline mutations of the fumarate hydratase (FH) gene, which encodes an enzyme component of the citric acid cycle and catalyzes the conversion of fumarate to L-malate.	Citric Acid	125-136	fumarate hydratase	Homo sapiens	74-76
34122722-5	2021	As a consequence of NF-kappaB inhibition, reduced promoter activities of SLC25A1-encoding the mitochondrial citrate carrier (CIC)-and ATP citrate lyase (ACLY) metabolic genes have been observed.	Citric Acid	108-115	nuclear factor kappa B subunit 1	Homo sapiens	20-29
34122722-5	2021	As a consequence of NF-kappaB inhibition, reduced promoter activities of SLC25A1-encoding the mitochondrial citrate carrier (CIC)-and ATP citrate lyase (ACLY) metabolic genes have been observed.	Citric Acid	108-115	solute carrier family 25 member 1	Homo sapiens	73-80
34122722-6	2021	CIC, ACLY, and citrate are components of the citrate pathway: in LPS-activated macrophages, the mitochondrial citrate is exported by CIC into the cytosol where it is cleaved by ACLY in oxaloacetate and acetyl-CoA, precursors for ROS, NO , and PGE2 inflammatory mediators.	Citric Acid	45-52	ATP citrate lyase	Homo sapiens	5-9
34122722-6	2021	CIC, ACLY, and citrate are components of the citrate pathway: in LPS-activated macrophages, the mitochondrial citrate is exported by CIC into the cytosol where it is cleaved by ACLY in oxaloacetate and acetyl-CoA, precursors for ROS, NO , and PGE2 inflammatory mediators.	Citric Acid	45-52	ATP citrate lyase	Homo sapiens	177-181
34122722-6	2021	CIC, ACLY, and citrate are components of the citrate pathway: in LPS-activated macrophages, the mitochondrial citrate is exported by CIC into the cytosol where it is cleaved by ACLY in oxaloacetate and acetyl-CoA, precursors for ROS, NO , and PGE2 inflammatory mediators.	Citric Acid	110-117	ATP citrate lyase	Homo sapiens	177-181
34179093-2	2021	The free energy of lysozyme interacting with two kinds of polyanionic excipients, citrate and tripolyphosphate, together with sodium chloride and TRIS-buffer, are analysed in multiple-walker metadynamics simulations to understand why tripolyphosphate causes lysozyme to precipitate but citrate does not.	Citric Acid	82-89	lysozyme	Homo sapiens	258-266
34122722-7	2021	We identify the citrate pathway as a RWP target in carrying out its anti-inflammatory activity since RWP reduces CIC and ACLY protein levels, ACLY enzymatic activity, the cytosolic citrate concentration, and in turn ROS, NO , PGE2, and histone acetylation levels.	Citric Acid	16-23	ATP citrate lyase	Homo sapiens	121-125
34122722-7	2021	We identify the citrate pathway as a RWP target in carrying out its anti-inflammatory activity since RWP reduces CIC and ACLY protein levels, ACLY enzymatic activity, the cytosolic citrate concentration, and in turn ROS, NO , PGE2, and histone acetylation levels.	Citric Acid	16-23	ATP citrate lyase	Homo sapiens	142-146
35302710-4	2022	Specifically, abrogation of SCO2 increased NAD+ regenerating reactions and decreased glucose oxidation through citric acid cycle while enhancing pyruvate carboxylation.	Citric Acid	111-122	synthesis of cytochrome C oxidase 2	Homo sapiens	28-32
34101804-1	2021	NaCT (SLC13A5) is a Na+-coupled transporter for citrate, which is expressed in the liver, brain, testes, and bone.	Citric Acid	48-55	solute carrier family 13 member 5	Homo sapiens	0-4
34101804-1	2021	NaCT (SLC13A5) is a Na+-coupled transporter for citrate, which is expressed in the liver, brain, testes, and bone.	Citric Acid	48-55	solute carrier family 13 member 5	Homo sapiens	6-13
34101804-2	2021	It is the mammalian homolog of Drosophila INDY, a cation-independent transporter for citrate, whose partial loss extends lifespan in the organism.	Citric Acid	85-92	I'm not dead yet	Drosophila melanogaster	42-46
34093433-6	2021	Pathway analysis further showed that citric acid cycle was the most differential metabolic pathway regulated by Cx43 channels.	Citric Acid	37-48	gap junction protein, alpha 3	Mus musculus	112-116
34064761-0	2021	KRAS, A Prime Mediator in Pancreatic Lipid Synthesis through Extra Mitochondrial Glutamine and Citrate Metabolism.	Citric Acid	95-102	KRAS proto-oncogene, GTPase	Homo sapiens	0-4
35452830-12	2022	CONCLUSION: CRRT with topical citrate + low-dose LMW heparin-calcium anticoagulation in the treatment of patients with SAP reduces the levels of WBC, CRP, and PCT and the concentrations of cytokines, including IL-6, IL-8, and TNF-alpha.	Citric Acid	30-37	interleukin 6	Homo sapiens	210-214
35452830-12	2022	CONCLUSION: CRRT with topical citrate + low-dose LMW heparin-calcium anticoagulation in the treatment of patients with SAP reduces the levels of WBC, CRP, and PCT and the concentrations of cytokines, including IL-6, IL-8, and TNF-alpha.	Citric Acid	30-37	C-X-C motif chemokine ligand 8	Homo sapiens	216-220
35452830-12	2022	CONCLUSION: CRRT with topical citrate + low-dose LMW heparin-calcium anticoagulation in the treatment of patients with SAP reduces the levels of WBC, CRP, and PCT and the concentrations of cytokines, including IL-6, IL-8, and TNF-alpha.	Citric Acid	30-37	tumor necrosis factor	Homo sapiens	226-235
35608902-0	2022	Citric acid of ovarian cancer metabolite induces pyroptosis via the caspase-4/TXNIP-NLRP3-GSDMD pathway in ovarian cancer.	Citric Acid	0-11	caspase 4	Homo sapiens	68-77
35608902-0	2022	Citric acid of ovarian cancer metabolite induces pyroptosis via the caspase-4/TXNIP-NLRP3-GSDMD pathway in ovarian cancer.	Citric Acid	0-11	thioredoxin interacting protein	Homo sapiens	78-83
35608902-0	2022	Citric acid of ovarian cancer metabolite induces pyroptosis via the caspase-4/TXNIP-NLRP3-GSDMD pathway in ovarian cancer.	Citric Acid	0-11	NLR family pyrin domain containing 3	Homo sapiens	84-89
35608902-0	2022	Citric acid of ovarian cancer metabolite induces pyroptosis via the caspase-4/TXNIP-NLRP3-GSDMD pathway in ovarian cancer.	Citric Acid	0-11	gasdermin D	Homo sapiens	90-95
35614500-6	2022	The desorption of Pr(III) from the loaded resin was achieved with 1.0 M citric acid at pH = 3 and found to be 58.0%.	Citric Acid	72-83	transmembrane protein 37	Homo sapiens	18-25
35598879-8	2022	Indeed, along with the known pathway of aspartate replenishing oxaloacetate, glutamine was shown to fuel citrate synthesis through both glutaminolysis and reductive carboxylation in a GLS1-dependent manner.	Citric Acid	105-112	glutaminase	Homo sapiens	184-188
35588018-8	2022	This metabolic adaptation promoted by IRAK4i in Spike protein-activated MThetas was shown to be in part through constraining PFKBF3, HIF1alpha, cMYC, LDHA, lactate expression, and reversal of citrate and succinate buildup.	Citric Acid	192-199	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	48-53
35593434-4	2022	URLi is a novel formulation of insulin lispro with accelerated absorption driven by 2 excipients: treprostinil, which increases local vasodilation, and citrate, which increases local vascular permeability.	Citric Acid	152-159	insulin	Homo sapiens	31-38
35626081-10	2022	Awaiting the development of non-toxic inhibitors of these enzymes, we propose to test the administration of citrate at a high dosage, because citrate is a physiologic inhibitor of both PFK1 and PFK2/PFKFB3.	Citric Acid	142-149	phosphofructokinase, muscle	Homo sapiens	185-189
35626081-10	2022	Awaiting the development of non-toxic inhibitors of these enzymes, we propose to test the administration of citrate at a high dosage, because citrate is a physiologic inhibitor of both PFK1 and PFK2/PFKFB3.	Citric Acid	142-149	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	194-198
35626081-10	2022	Awaiting the development of non-toxic inhibitors of these enzymes, we propose to test the administration of citrate at a high dosage, because citrate is a physiologic inhibitor of both PFK1 and PFK2/PFKFB3.	Citric Acid	142-149	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	199-205
35626081-11	2022	Consistently, in various cultured cancer cells (including melanoma, sarcoma, hematologic, and epithelial cancer cells), this "citrate strategy" efficiently inhibits the IGFR1/AKT pathway, promotes PTEN activity, reduces Bcl-xL and MCL1 expression, and increases sensitivity to standard chemotherapy.	Citric Acid	126-133	Fc gamma receptor Ic, pseudogene	Homo sapiens	169-174
35626081-11	2022	Consistently, in various cultured cancer cells (including melanoma, sarcoma, hematologic, and epithelial cancer cells), this "citrate strategy" efficiently inhibits the IGFR1/AKT pathway, promotes PTEN activity, reduces Bcl-xL and MCL1 expression, and increases sensitivity to standard chemotherapy.	Citric Acid	126-133	AKT serine/threonine kinase 1	Homo sapiens	175-178
35626081-11	2022	Consistently, in various cultured cancer cells (including melanoma, sarcoma, hematologic, and epithelial cancer cells), this "citrate strategy" efficiently inhibits the IGFR1/AKT pathway, promotes PTEN activity, reduces Bcl-xL and MCL1 expression, and increases sensitivity to standard chemotherapy.	Citric Acid	126-133	phosphatase and tensin homolog	Homo sapiens	197-201
35626081-11	2022	Consistently, in various cultured cancer cells (including melanoma, sarcoma, hematologic, and epithelial cancer cells), this "citrate strategy" efficiently inhibits the IGFR1/AKT pathway, promotes PTEN activity, reduces Bcl-xL and MCL1 expression, and increases sensitivity to standard chemotherapy.	Citric Acid	126-133	BCL2 like 1	Homo sapiens	220-226
35626081-11	2022	Consistently, in various cultured cancer cells (including melanoma, sarcoma, hematologic, and epithelial cancer cells), this "citrate strategy" efficiently inhibits the IGFR1/AKT pathway, promotes PTEN activity, reduces Bcl-xL and MCL1 expression, and increases sensitivity to standard chemotherapy.	Citric Acid	126-133	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	231-235
35585086-5	2022	Mechanistically, IRAKM interacts with and phosphorylates mitochondrial citrate carrier Slc25a1 to promote IL-1beta-induced mitochondrial citrate transport to cytosol and de novo lipogenesis.	Citric Acid	71-78	interleukin-1 receptor-associated kinase 3	Mus musculus	17-22
35585086-5	2022	Mechanistically, IRAKM interacts with and phosphorylates mitochondrial citrate carrier Slc25a1 to promote IL-1beta-induced mitochondrial citrate transport to cytosol and de novo lipogenesis.	Citric Acid	71-78	solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1	Mus musculus	87-94
35585086-5	2022	Mechanistically, IRAKM interacts with and phosphorylates mitochondrial citrate carrier Slc25a1 to promote IL-1beta-induced mitochondrial citrate transport to cytosol and de novo lipogenesis.	Citric Acid	71-78	interleukin 1 alpha	Mus musculus	106-114
35585086-5	2022	Mechanistically, IRAKM interacts with and phosphorylates mitochondrial citrate carrier Slc25a1 to promote IL-1beta-induced mitochondrial citrate transport to cytosol and de novo lipogenesis.	Citric Acid	137-144	interleukin-1 receptor-associated kinase 3	Mus musculus	17-22
35585086-5	2022	Mechanistically, IRAKM interacts with and phosphorylates mitochondrial citrate carrier Slc25a1 to promote IL-1beta-induced mitochondrial citrate transport to cytosol and de novo lipogenesis.	Citric Acid	137-144	solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1	Mus musculus	87-94
35585086-5	2022	Mechanistically, IRAKM interacts with and phosphorylates mitochondrial citrate carrier Slc25a1 to promote IL-1beta-induced mitochondrial citrate transport to cytosol and de novo lipogenesis.	Citric Acid	137-144	interleukin 1 alpha	Mus musculus	106-114
35471551-7	2022	The DIA data were further confirmed by a markedly reduction of intermediate metabolites (citrate and fumarate) in TCA cycle and terminal metabolite (ATP) in OXPHOS system after disruption of PRSS37.	Citric Acid	89-96	protease, serine 37	Mus musculus	191-197
35433126-3	2022	However, diurnal variations and sex differences in salivary alpha-amylase (sAA), pH, salivary flow rate (SFR), and salivary cortisol before and after citric acid stimulation remain unclear.	Citric Acid	150-161	amylase alpha 1A	Homo sapiens	51-73
35404187-0	2022	Selective autophagic degradation of ACLY (ATP citrate lyase) maintains citrate homeostasis and promotes oocyte maturation.	Citric Acid	71-78	ATP citrate lyase	Homo sapiens	36-40
35404187-0	2022	Selective autophagic degradation of ACLY (ATP citrate lyase) maintains citrate homeostasis and promotes oocyte maturation.	Citric Acid	71-78	ATP citrate lyase	Homo sapiens	42-59
35404187-6	2022	Mechanistically, we found that ACLY (ATP citrate lyase), which is a crucial enzyme catalyzing the cleavage of citrate, was preferentially associated with K63-linked ubiquitin chains and recognized by the autophagy receptor protein SQSTM1/p62 for selective autophagic degradation.	Citric Acid	110-117	ATP citrate lyase	Homo sapiens	31-35
35404187-6	2022	Mechanistically, we found that ACLY (ATP citrate lyase), which is a crucial enzyme catalyzing the cleavage of citrate, was preferentially associated with K63-linked ubiquitin chains and recognized by the autophagy receptor protein SQSTM1/p62 for selective autophagic degradation.	Citric Acid	110-117	ATP citrate lyase	Homo sapiens	37-54
35404187-6	2022	Mechanistically, we found that ACLY (ATP citrate lyase), which is a crucial enzyme catalyzing the cleavage of citrate, was preferentially associated with K63-linked ubiquitin chains and recognized by the autophagy receptor protein SQSTM1/p62 for selective autophagic degradation.	Citric Acid	110-117	sequestosome 1	Homo sapiens	231-237
35404187-6	2022	Mechanistically, we found that ACLY (ATP citrate lyase), which is a crucial enzyme catalyzing the cleavage of citrate, was preferentially associated with K63-linked ubiquitin chains and recognized by the autophagy receptor protein SQSTM1/p62 for selective autophagic degradation.	Citric Acid	110-117	sequestosome 1	Homo sapiens	238-241
35404187-9	2022	Collectively, our data reveal that autophagy in granulosa cells is a beneficial mechanism to maintain a certain degree of citrate by selectively targeting ACLY during oocyte maturation.	Citric Acid	122-129	ATP citrate lyase	Homo sapiens	155-159
35500386-10	2022	These changes were attributed to protein specific salt effects of citrate on bovine serum albumin and magnesium on alpha-chymotrypsin.	Citric Acid	66-73	albumin	Homo sapiens	84-97
35203088-3	2022	AT-1 overexpressing neurons maintain the cytosolic pool of acetyl-CoA by upregulation of SLC25A1, the mitochondrial citrate/malate antiporter and ATP citrate lyase, which converts cytosolic citrate into acetyl-CoA.	Citric Acid	190-197	solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1	Mus musculus	89-96
35203088-3	2022	AT-1 overexpressing neurons maintain the cytosolic pool of acetyl-CoA by upregulation of SLC25A1, the mitochondrial citrate/malate antiporter and ATP citrate lyase, which converts cytosolic citrate into acetyl-CoA.	Citric Acid	190-197	ATP citrate lyase	Mus musculus	146-163
35428174-5	2022	The results showed that IMF deposition in BM was associated with pyruvate and citric acid metabolism through GAPDH, LDHA, GPX1, GBE1, and other genes.	Citric Acid	78-89	glyceraldehyde-3-phosphate dehydrogenase	Gallus gallus	109-114
35428174-5	2022	The results showed that IMF deposition in BM was associated with pyruvate and citric acid metabolism through GAPDH, LDHA, GPX1, GBE1, and other genes.	Citric Acid	78-89	lactate dehydrogenase A	Gallus gallus	116-120
35428174-5	2022	The results showed that IMF deposition in BM was associated with pyruvate and citric acid metabolism through GAPDH, LDHA, GPX1, GBE1, and other genes.	Citric Acid	78-89	glutathione peroxidase 1	Gallus gallus	122-126
35428174-5	2022	The results showed that IMF deposition in BM was associated with pyruvate and citric acid metabolism through GAPDH, LDHA, GPX1, GBE1, and other genes.	Citric Acid	78-89	1,4-alpha-glucan branching enzyme 1	Gallus gallus	128-132
35448538-2	2022	SLC13A5 protein deficiency reduces citrate transport into the cell.	Citric Acid	35-42	solute carrier family 13 member 5	Homo sapiens	0-7
35433126-6	2022	Results: There were circadian fluctuations in sAA activity, SFR, pH, and cortisol level both before and after citric acid stimulation, and the diurnal fluctuations of these indexes were not affected by citric acid stimulation.	Citric Acid	110-121	serum amyloid A1 cluster	Homo sapiens	46-49
35405936-9	2022	(3) Results: Women with type 2 diabetes had a slower increase in breastmilk citrate concentration postpartum, indicative of delayed SA, compared to both control groups.	Citric Acid	76-83	acyl-CoA synthetase medium chain family member 3	Homo sapiens	132-134
35353621-5	2022	Pyruvate carboxylase provides sufficient anaplerotic carbons to support citrate secretion.	Citric Acid	72-79	pyruvate carboxylase	Homo sapiens	0-20
35359923-9	2022	Thirty-nine proteins were found highly expressed in axSpA uniquely, RNA-binding protein 8A and protein transport protein Sec24C included, whose bioinformatic analysis was significantly involved in "acute-phase response" and "citrate cycle".	Citric Acid	225-232	RNA binding motif protein 8A	Homo sapiens	68-90
35359923-9	2022	Thirty-nine proteins were found highly expressed in axSpA uniquely, RNA-binding protein 8A and protein transport protein Sec24C included, whose bioinformatic analysis was significantly involved in "acute-phase response" and "citrate cycle".	Citric Acid	225-232	SEC24 homolog C, COPII coat complex component	Homo sapiens	121-127
34857466-6	2022	With the addition of citrate, the fluorescence of GMP/Tb at 545 nm was significantly quenched, contrasting to the enhancement of fluorescence of CDs at 454 nm.	Citric Acid	21-28	5'-nucleotidase, cytosolic II	Homo sapiens	50-53
35066423-4	2022	When the citrate buffer was used, in which there is buffering capacity in the pH range studied, the maximum of Syn aggregation was very close to the isoelectric point (pI = 4.7).	Citric Acid	9-16	synemin	Homo sapiens	111-114
35264789-5	2022	Genetic co-essentiality mapping revealed a cluster of genes that is sufficient to compose a biochemical alternative to the canonical TCA cycle, wherein mitochondrially derived citrate exported to the cytoplasm is metabolized by ATP citrate lyase, ultimately regenerating mitochondrial oxaloacetate to complete this non-canonical TCA cycle.	Citric Acid	176-183	ATP citrate lyase	Homo sapiens	228-245
35133638-12	2022	CONCLUSIONS: XC8 acts against cough evoked by the activation of TRPA1 (citric acid/cinnamaldehyde) but not TRPV1 (capsaicin) channels.	Citric Acid	71-82	transient receptor potential cation channel subfamily A member 1	Homo sapiens	64-69
35204826-0	2022	A Potential Citrate Shunt in Erythrocytes of PKAN Patients Caused by Mutations in Pantothenate Kinase 2.	Citric Acid	12-19	pantothenate kinase 2	Homo sapiens	45-49
35204826-0	2022	A Potential Citrate Shunt in Erythrocytes of PKAN Patients Caused by Mutations in Pantothenate Kinase 2.	Citric Acid	12-19	pantothenate kinase 2	Homo sapiens	82-103
35204826-8	2022	Assuming low/absent CoA levels in PKAN erythrocytes, changes are consistent with a model of altered citrate channeling where citrate is preferentially converted to alpha-ketoglutarate and alpha-hydroxyglutarate instead of being used for de novo acetyl-CoA generation.	Citric Acid	125-132	pantothenate kinase 2	Homo sapiens	34-38
35172156-0	2022	Blockage of citrate export prevents TCA cycle fragmentation via Irg1 inactivation.	Citric Acid	12-19	aconitate decarboxylase 1	Homo sapiens	64-68
35592618-2	2022	Until recently, treatment of PH1 was supportive, consisting of intensive hyperhydration, use of crystallization inhibitors (citrate and neutral phosphorus), in a subset of responsive PH1 patients" pharmacologic doses of vitamin B6 (pyridoxine), and kidney and liver transplantation when patients progressed to kidney failure.	Citric Acid	124-131	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	29-32
35149585-7	2022	Overexpression of GAPDHS was sufficient to block melanoma metastasis, while its inhibition promoted metastasis, decreased glycolysis, and increased levels of certain TCA cycle metabolites and their derivatives including citrate, fumarate, malate, and aspartate.	Citric Acid	220-227	glyceraldehyde-3-phosphate dehydrogenase, spermatogenic	Homo sapiens	18-24
35176280-7	2022	We found that deletion of G6pc2 led to ~60% increases in glycolytic and citric acid cycle (CAC) fluxes at both 5 and 11 mM glucose concentrations.	Citric Acid	72-83	glucose-6-phosphatase, catalytic, 2	Mus musculus	26-31
35176280-10	2022	These results demonstrate that G6pc2 regulates GSIS by modulating not only glycolysis but also, independently, citric acid cycle activity in beta-cells.	Citric Acid	111-122	glucose-6-phosphatase, catalytic, 2	Mus musculus	31-36
35152003-6	2022	RNA sequencing revealed that citrate cycle-related genes were positively enriched in the renal tissues of RTEC-specific Tipe1 knockout mice.	Citric Acid	29-36	tumor necrosis factor, alpha-induced protein 8-like 1	Mus musculus	120-125
35355147-0	2022	Effects of regional citrate anticoagulation on thrombin generation, fibrinolysis and platelet function in critically ill patients receiving continuous renal replacement therapy for acute kidney injury: a prospective study.	Citric Acid	20-27	coagulation factor II, thrombin	Homo sapiens	47-55
35425793-3	2022	Our results showed that amniotic fluid had a decrease (P < 0.05) in the concentrations of glucose, insulin and hepatocyte growth factor as pregnancy progressed, while maternal serum exhibited the highest concentrations of glucose and insulin at 75 days of gestation (P < 0.05), and a significant positive correlation (P < 0.05) between insulin and citric acid.	Citric Acid	348-359	hepatocyte growth factor	Homo sapiens	111-135
35425793-3	2022	Our results showed that amniotic fluid had a decrease (P < 0.05) in the concentrations of glucose, insulin and hepatocyte growth factor as pregnancy progressed, while maternal serum exhibited the highest concentrations of glucose and insulin at 75 days of gestation (P < 0.05), and a significant positive correlation (P < 0.05) between insulin and citric acid.	Citric Acid	348-359	insulin	Homo sapiens	234-241
35402505-6	2022	To do this, we used genome editing to knock out ATP citrate lyase (ACLY), the enzyme responsible for converting citrate to oxaloacetate and acetyl-CoA in the cytoplasm and nucleus.	Citric Acid	112-119	ATP citrate lyase	Homo sapiens	48-65
35402505-6	2022	To do this, we used genome editing to knock out ATP citrate lyase (ACLY), the enzyme responsible for converting citrate to oxaloacetate and acetyl-CoA in the cytoplasm and nucleus.	Citric Acid	112-119	ATP citrate lyase	Homo sapiens	67-71
35448460-8	2022	Whereas BI01383298 inhibited only human NaCT-mediated citrate uptake, it inhibits the uptake of arginine and derivatives mediated by both human NaCT and mouse Nact.	Citric Acid	54-61	solute carrier family 13 member 5	Homo sapiens	40-44
35448460-9	2022	In contrast, the prototypic substrate citrate inhibited the transport of arginine and derivatives mediated only by human NaCT.	Citric Acid	38-45	solute carrier family 13 member 5	Homo sapiens	121-125
35434198-5	2022	The functioning of the roTCA cycle requires unusually high activity of citrate synthase, the enzyme responsible for citrate cleavage, as well as elevated CO2 partial pressures.	Citric Acid	116-123	citrate synthase	Homo sapiens	71-87
35260871-2	2022	The zeta potential of lysozyme varies significantly at the same buffer concentration, in the order Tris > phosphate > citrate, with citrate even inverting the zeta potential, usually positive at pH 7.15, to a negative value.	Citric Acid	118-125	lysozyme	Homo sapiens	22-30
35260871-2	2022	The zeta potential of lysozyme varies significantly at the same buffer concentration, in the order Tris > phosphate > citrate, with citrate even inverting the zeta potential, usually positive at pH 7.15, to a negative value.	Citric Acid	132-139	lysozyme	Homo sapiens	22-30
35226893-7	2022	Selective up-regulation of chondrogenesis-related genes (COL2A1andACAN) was found for the magnetic scaffolds with citric acid-coated MNPs (CAG).	Citric Acid	114-125	collagen type II alpha 1 chain	Homo sapiens	57-70
35484745-0	2022	Gold-Nanoparticle-Conjugated Citrate Inhibits Tumor Necrosis Factor-alpha Expression via Suppression of Nuclear Factor Kappa B (NF-kappaB) Activation in Breast Cancer Cells.	Citric Acid	29-36	tumor necrosis factor	Homo sapiens	46-73
35159907-2	2022	We explored and compared the loading/release ability of diclofenac (COX-2 antagonist), in both undoped- and luminescent Terbium3+ (Tb3+)-doped citrate-coated carbonated apatite nanoparticles at different temperatures (25, 37, 40  C) and pHs (7.4, 5.2).	Citric Acid	143-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
35484745-3	2022	In this study, we aimed to determine the therapeutic role of novel gold nanoparticles conjugated with citrate (AuNPs-CIT) on the elevated expression of TNF-alpha in breast cancer cells.	Citric Acid	102-109	tumor necrosis factor	Homo sapiens	152-161
35484745-0	2022	Gold-Nanoparticle-Conjugated Citrate Inhibits Tumor Necrosis Factor-alpha Expression via Suppression of Nuclear Factor Kappa B (NF-kappaB) Activation in Breast Cancer Cells.	Citric Acid	29-36	nuclear factor kappa B subunit 1	Homo sapiens	104-126
35484745-0	2022	Gold-Nanoparticle-Conjugated Citrate Inhibits Tumor Necrosis Factor-alpha Expression via Suppression of Nuclear Factor Kappa B (NF-kappaB) Activation in Breast Cancer Cells.	Citric Acid	29-36	nuclear factor kappa B subunit 1	Homo sapiens	128-137
35048959-7	2022	Further, citrate, isocitrate, and malate were observed to activate human LDH-A, both at pH 5.0 and 6.5, with citrate and isocitrate being responsible for major effects.	Citric Acid	9-16	lactate dehydrogenase A	Homo sapiens	73-78
35048959-7	2022	Further, citrate, isocitrate, and malate were observed to activate human LDH-A, both at pH 5.0 and 6.5, with citrate and isocitrate being responsible for major effects.	Citric Acid	109-116	lactate dehydrogenase A	Homo sapiens	73-78
34935845-4	2022	Herein, we report the synthesis of HA nanoparticles coordinated by citric acid (Cit/HA) based on the interactions between carboxylate and calcium ions to control the sizes and shapes of the hybrid nanoparticles, to improve their dispersibility in water and to eventually form uniform transparent films with nanospaces, and investigated the film formation mechanism.	Citric Acid	67-78	citron rho-interacting serine/threonine kinase	Homo sapiens	80-83
35098993-2	2022	Few people know that one of the roots of this new paradigm in cell biology can be traced to a serendipitous discovery by an obscure Russian biochemist, Boris Belousov, who was studying the oxidation of citric acid.	Citric Acid	202-213	CCCTC-binding factor like	Homo sapiens	152-157
34951613-2	2022	We previously demonstrated that citrate-stabilized gold nanoparticles (Cit-AuNPs) interact with beta2-microglobulin (beta2m) preserving the protein native structure.	Citric Acid	32-39	beta-2-microglobulin	Homo sapiens	96-115
34951613-2	2022	We previously demonstrated that citrate-stabilized gold nanoparticles (Cit-AuNPs) interact with beta2-microglobulin (beta2m) preserving the protein native structure.	Citric Acid	32-39	alpha-2-macroglobulin	Homo sapiens	117-123
35343271-10	2022	These beneficial effects are accompanied by a stimulus of the citric acid cycle-which feed the mitochondrial complexes with the electrons removed from different substrates-as the result of accentuated stimulus of citrate synthase activity by BMMC.	Citric Acid	62-73	citrate synthase	Homo sapiens	213-229
35021096-0	2022	NHR-80 senses the mitochondrial UPR to rewire citrate metabolism for lipid accumulation in Caenorhabditis elegans.	Citric Acid	46-53	Nuclear Hormone Receptor family	Caenorhabditis elegans	0-6
35021096-4	2022	Here, we show that inactivation of either the citric/tricarboxylic acid (TCA) cycle enzymes aco-2 or idha-1, which encode aconitase and isocitrate dehydrogenase respectively, leads to citrate accumulation.	Citric Acid	46-52	putative aconitate hydratase, mitochondrial	Caenorhabditis elegans	92-97
35021096-4	2022	Here, we show that inactivation of either the citric/tricarboxylic acid (TCA) cycle enzymes aco-2 or idha-1, which encode aconitase and isocitrate dehydrogenase respectively, leads to citrate accumulation.	Citric Acid	46-52	putative isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	Caenorhabditis elegans	101-107
35021096-4	2022	Here, we show that inactivation of either the citric/tricarboxylic acid (TCA) cycle enzymes aco-2 or idha-1, which encode aconitase and isocitrate dehydrogenase respectively, leads to citrate accumulation.	Citric Acid	46-52	Isocitrate dehydrogenase [NADP]	Caenorhabditis elegans	122-160
35021096-4	2022	Here, we show that inactivation of either the citric/tricarboxylic acid (TCA) cycle enzymes aco-2 or idha-1, which encode aconitase and isocitrate dehydrogenase respectively, leads to citrate accumulation.	Citric Acid	184-191	putative aconitate hydratase, mitochondrial	Caenorhabditis elegans	92-97
35021096-4	2022	Here, we show that inactivation of either the citric/tricarboxylic acid (TCA) cycle enzymes aco-2 or idha-1, which encode aconitase and isocitrate dehydrogenase respectively, leads to citrate accumulation.	Citric Acid	184-191	putative isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	Caenorhabditis elegans	101-107
35021096-4	2022	Here, we show that inactivation of either the citric/tricarboxylic acid (TCA) cycle enzymes aco-2 or idha-1, which encode aconitase and isocitrate dehydrogenase respectively, leads to citrate accumulation.	Citric Acid	184-191	Isocitrate dehydrogenase [NADP]	Caenorhabditis elegans	122-160
35021096-7	2022	NHR-80 then upregulates lipogenesis and lipid accumulation, shifting excess citrate for use in lipogenesis and for storage as triacylglycerol in lipid droplets.	Citric Acid	76-83	Nuclear Hormone Receptor family	Caenorhabditis elegans	0-6
34591307-2	2022	Here, we describe an injectable, citrate-containing polyester hydrogel which can release citrate as a cell regulator via hydrogel degradation and simultaneously show sustained release of an encapsulated myeloid-derived growth factor (Mydgf).	Citric Acid	33-40	myeloid-derived growth factor	Rattus norvegicus	203-232
35444834-6	2022	(2021) demonstrate that mitochondrial function is impaired in CD4+ T cells from RA patients, leading to reduced levels of various citric acid cycle metabolites (e.g., aspartate) that regulate TNF-alpha production.	Citric Acid	130-141	CD4 molecule	Homo sapiens	62-65
35444834-6	2022	(2021) demonstrate that mitochondrial function is impaired in CD4+ T cells from RA patients, leading to reduced levels of various citric acid cycle metabolites (e.g., aspartate) that regulate TNF-alpha production.	Citric Acid	130-141	tumor necrosis factor	Homo sapiens	192-201
34591307-2	2022	Here, we describe an injectable, citrate-containing polyester hydrogel which can release citrate as a cell regulator via hydrogel degradation and simultaneously show sustained release of an encapsulated myeloid-derived growth factor (Mydgf).	Citric Acid	33-40	myeloid-derived growth factor	Rattus norvegicus	234-239
34591307-6	2022	The authors also observed improved postmyocardial infarction (MI) heart repair in a rat MI model through coupling the therapeutic effect of the hydrogel degradation product (citrate) with encapsulated Mydgf.	Citric Acid	174-181	myeloid-derived growth factor	Rattus norvegicus	201-206
34591307-9	2022	Their results showed that the intramyocardial injection of Mydgf-loaded citrate-containing hydrogel significantly reduced scar formation and infarct size, increased wall thickness and neovascularization, and improved heart function.	Citric Acid	72-79	myeloid-derived growth factor	Rattus norvegicus	59-64
2556968-10	1989	NADH-dependent lipid peroxidation was much lower than the NADPH-catalyzed reaction and showed an opposite response to catalysis by ferric complexes compared to .OH generation as production of thiobarbituric acid-reactive material was increased with ferric-ATP and -citrate, but not with ferric-EDTA or- DTPA, and was not affected by catalase, SOD, or .OH scavengers.	Citric Acid	264-272	2,4-dienoyl-CoA reductase 1	Homo sapiens	0-4
35005550-5	2022	High-throughput transcriptomic and MS-metabolomic profiling of IL-32 KO cells revealed that cells depleted of IL-32 had perturbations in metabolic pathways, with accumulation of lipids, pyruvate precursors, and citrate.	Citric Acid	211-218	interleukin 32	Homo sapiens	63-68
35005550-5	2022	High-throughput transcriptomic and MS-metabolomic profiling of IL-32 KO cells revealed that cells depleted of IL-32 had perturbations in metabolic pathways, with accumulation of lipids, pyruvate precursors, and citrate.	Citric Acid	211-218	interleukin 32	Homo sapiens	110-115
2793057-3	1989	It has been demonstrated that seminal catalase originated from prostate; however, its activity was not correlated with the usual prostatic markers (such as citric acid and zinc).	Citric Acid	156-167	catalase	Homo sapiens	38-46
2746239-8	1989	Preincubation of aluminum with citrate, NADP+, EDTA, NaF, ATP, and apotransferrin protected the G6PD isozymes against aluminum inactivation.	Citric Acid	31-38	glucose-6-phosphate dehydrogenase	Homo sapiens	96-100
2768270-13	1989	When pH, aluminum, citrate, phosphate, substrates, and products were maintained at cellular levels measured under anoxia, we can account for a 90% inhibition of hexokinase relative to activity under control (aerobic) conditions.	Citric Acid	19-26	hexokinase 1	Homo sapiens	161-171
2760172-5	1989	Citrate-induced hypocalcemia produced a rise in serum PTH levels from 28.1 +/- 3.6 to 69.4 +/- 4.8 ng/L as calcium fell from 1.26 +/- 0.01 to 1.06 +/- 0.02 mmol/L.	Citric Acid	0-7	parathyroid hormone	Homo sapiens	54-57
2760172-10	1989	When citrate was used to return calcium to baseline, PTH levels rose from 7.8 +/- 2.0 to 55.0 +/- 6.8 ng/L as calcium fell from 1.42 +/- 0.02 to 1.26 +/- 0.02 mmol/L and defined a regression relationship significantly different from the period of increasing calcium.	Citric Acid	5-12	parathyroid hormone	Homo sapiens	53-56
2779524-2	1989	There was a marked reduction in the rate of urinary excretion of citrate, 2-oxoglutarate, and succinate within 4.5 hr of the administration of 24 mumol/kg Cd2+.	Citric Acid	65-72	Cd2 molecule	Rattus norvegicus	155-158
2759092-0	1989	The visualization by affinity electrophoresis of a specific association between the consecutive citric acid cycle enzymes fumarase and malate dehydrogenase.	Citric Acid	96-107	fumarate hydratase	Homo sapiens	122-130
2759092-0	1989	The visualization by affinity electrophoresis of a specific association between the consecutive citric acid cycle enzymes fumarase and malate dehydrogenase.	Citric Acid	96-107	malic enzyme 2	Homo sapiens	135-155
2759092-17	1989	The latter findings are suggestive of an interruption of the citric acid cycle at the level of fumarase under conditions of high energy load (i.e. high ATP/ADP ratios).	Citric Acid	61-72	fumarate hydratase	Homo sapiens	95-103
2529663-5	1989	PAI-1 activity showed the same level in all citrate based anticoagulants and ETP and no increase was found in blood standing for 2 hours at room temperature.	Citric Acid	44-51	serpin family E member 1	Homo sapiens	0-5
2700116-2	1989	Citric acid pH1 and 50 per cent phosphoric acid were topically applied to thoroughly scaled and planed root surfaces for one to three minutes.	Citric Acid	0-11	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	12-15
2619313-6	1989	Citric acid was lower at sea level than in NA and MMC.	Citric Acid	0-11	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	25-28
2920849-4	1989	Serum PRL was higher in azoospermia and also in subjects with lower levels of seminal citric acid.	Citric Acid	86-97	prolactin	Homo sapiens	6-9
2920849-6	1989	Seminal PRL was increased in subjects with higher levels of seminal citric acid and decreased in subjects with lower levels of corrected seminal fructose.	Citric Acid	68-79	prolactin	Homo sapiens	8-11
2661160-5	1989	There was a positive correlation between KL-6 antigen levels and the degree of clinical disease activity as measured by 67Ga-citrate scintigram and the clinical course.	Citric Acid	125-132	mucin 1, cell surface associated	Homo sapiens	41-45
2731546-1	1989	Arguments are presented which indicate that the low steady-state rates of citrate production governing the catalytic interaction of citrate synthase from pig heart with citryl-CoA reflect the formation of a non-productive enzyme.citryl-CoA complex.	Citric Acid	74-81	citrate synthase	Sus scrofa	132-148
2466835-6	1989	It is proposed that non-transferrin-bound iron in the plasma of iron-overloaded patients exists largely as complexes with citrate and possibly also as ternary iron-citrate-acetate complexes.	Citric Acid	122-129	transferrin	Homo sapiens	24-35
2645827-0	1989	Effect of esters of succinic acid and other citric acid cycle intermediates on insulin release and inositol phosphate formation by pancreatic islets.	Citric Acid	44-55	insulin	Homo sapiens	79-86
2497449-0	1989	Citrate activates tyrosinase from B-16 murine melanoma and human skin.	Citric Acid	0-7	tyrosinase	Mus musculus	18-28
2746239-9	1989	However, when the G6PD isozymes were completely inactivated by aluminum, only citrate, NaF, and apotransferrin restored the enzyme activity.	Citric Acid	78-85	glucose-6-phosphate dehydrogenase	Homo sapiens	18-22
2512904-6	1989	Thus, stimulation with citric acid causes a significant decrease in tPA activity of parotid saliva but this decrease, as well as the reduction rate, appears to be independent of flow rate.	Citric Acid	23-34	chromosome 20 open reading frame 181	Homo sapiens	68-71
2688562-5	1989	The IgA deposits which could not be removed by this treatment were eluted by a combination of low pH (0.5 M citrate pH 2) and a chaotropic agent (2 M NaCl).	Citric Acid	108-115	CD79a molecule	Homo sapiens	4-7
2804473-1	1989	Rhodium II citrate was tested in mice for acute toxicity, antitumoral activity against Ehrlich ascites carcinoma and inhibition of DNA synthesis by Ehrlich tumor, malignant adrenocortical cells (Y-1) and normal adrenocortical cells (AR-1).	Citric Acid	11-18	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	195-198
3146144-3	1988	When [Ca2+]o is decreased by addition of citrate to hirudin-PRP or when no CaCl2 is added to washed platelet suspensions, ASvWf does induce platelet aggregation and the release reaction.	Citric Acid	41-48	prion protein	Homo sapiens	60-63
2591351-5	1989	The binding between glucosylceramidase and the substrate-containing particles is dramatically depressed by changes of experimental conditions which negatively influence also the enzyme activity such as: (1) a decrease in the molarity of the citrate/phosphate buffer; (2) an increase of the buffer pH, and (3) an increase of the taurocholate concentration.	Citric Acid	241-248	glucosylceramidase beta	Homo sapiens	20-38
2906959-7	1988	However, hepatic levels of citrate, an allosteric activator of acetyl-CoA carboxylase, were significantly elevated (51%) within 90 min of TNF treatment.	Citric Acid	27-34	tumor necrosis factor-like	Rattus norvegicus	138-141
2906959-10	1988	These data suggest that TNF acutely regulates hepatic fatty acid synthesis in vivo by raising hepatic levels of citrate.	Citric Acid	112-119	tumor necrosis factor-like	Rattus norvegicus	24-27
3414320-5	1988	However, this effect was abolished if a known CBG inhibitor, phosphate:citrate buffer at pH 4, was used as the diluent in the assay.	Citric Acid	71-78	serpin family A member 6	Homo sapiens	46-49
3054048-4	1988	Fibronectin, which had previously been isolated from the patient"s own plasma, was applied with a tuberculin syringe on the citric acid demineralized root surfaces and the inner aspect of the flap.	Citric Acid	124-135	fibronectin 1	Homo sapiens	0-11
3343546-5	1988	When blood from one donor was collected into 10 mmol/L and 20 mmol/L citrate, increased binding of 125I-fibrinogen was observed on platelets exposed to 20 mmol/L citrate.	Citric Acid	162-169	fibrinogen beta chain	Homo sapiens	104-114
3355862-2	1988	Iron complexes of DL-penicillamine, citrate and six different aroyl hydrazones may be utilized by immature erythroid cells for hemoglobin synthesis, although less efficiently than iron from transferrin.	Citric Acid	36-43	serotransferrin	Oryctolagus cuniculus	190-201
2455358-3	1988	A good correlation between precipitable (sulphite) and functional (clotting rate) fibrinogen levels was observed in plasma collected on citrate before therapy (r = 0.76) and in samples collected after 3 hours on either aprotinin (r = 0.87) or PPACK (r = 0.82).	Citric Acid	136-143	fibrinogen beta chain	Homo sapiens	82-92
2455358-4	1988	Precipitable fibrinogen levels were approximately 10% higher than functional level, in baseline samples collected on citrate alone and approximately 20% higher in 3 hour samples collected on either PPACK or aprotinin.	Citric Acid	117-124	fibrinogen beta chain	Homo sapiens	13-23
3278998-8	1988	Metal uptake from the citrate complex can be prevented only by the presence of other chelating agents and/or by transferrin.	Citric Acid	22-29	transferrin	Homo sapiens	112-123
3343546-2	1988	Because citrate has been reported to affect platelet function, we examined the involvement of citrate on the platelet-fibrinogen interactions.	Citric Acid	94-101	fibrinogen beta chain	Homo sapiens	118-128
3343546-3	1988	More iodine 125-labeled fibrinogen was bound on washed platelets from citrate-anticoagulated blood (CP) than on washed platelets from non-anticoagulated blood (PNB) obtained by the rapid gel filtration of native blood from the same donor.	Citric Acid	70-77	fibrinogen beta chain	Homo sapiens	24-34
3343546-5	1988	When blood from one donor was collected into 10 mmol/L and 20 mmol/L citrate, increased binding of 125I-fibrinogen was observed on platelets exposed to 20 mmol/L citrate.	Citric Acid	69-76	fibrinogen beta chain	Homo sapiens	104-114
2497449-1	1989	Citrate stimulates cresolase activity of tyrosinase from B-16 murine melanoma and human skin.	Citric Acid	0-7	tyrosinase	Mus musculus	41-51
2497449-3	1989	Citrate stimulates tyrosinase not only from mammalian sources but also from mushroom.	Citric Acid	0-7	tyrosinase	Homo sapiens	19-29
2497449-10	1989	The physiological role of stimulation of cresolase activity of tyrosinase by citrate is yet to be unravelled.	Citric Acid	77-84	tyrosinase	Homo sapiens	63-73
2899080-0	1988	Regulation of malate dehydrogenase activity by glutamate, citrate, alpha-ketoglutarate, and multienzyme interaction.	Citric Acid	58-65	malic enzyme 2	Homo sapiens	14-34
2899080-7	1988	This would maintain the catalytic activity of the multienzyme system because alpha-ketoglutarate and citrate allosterically inhibit malate dehydrogenase and dissociate this enzyme from the multienzyme system.	Citric Acid	101-108	malic enzyme 2	Homo sapiens	132-152
2899080-8	1988	In addition, citrate also competitively inhibits fumarase.	Citric Acid	13-20	fumarate hydratase	Homo sapiens	49-57
2459580-5	1988	These transformation-associated deviations from the normally high amounts of citrate and low amounts of lipids in the prostate are consistent with an alteration in either the concentration or the activity of ATP-citrate lyase in the tumors.	Citric Acid	77-84	ATP citrate lyase	Homo sapiens	208-225
3048387-1	1988	Citrate synthase is a key enzyme of the Krebs tricarboxylic acid cycle and catalyzes the stereospecific synthesis of citrate from acetyl coenzyme A and oxalacetate.	Citric Acid	117-124	citrate synthase	Sus scrofa	0-16
3343546-6	1988	Exposure of PNB to varying citrate concentrations showed enhanced fibrinogen binding with increasing citrate concentrations; differences in the Kd values between non-citrate-treated PNB and citrate-treated PNB were apparent at about 7.5 mmol/L of citrate.	Citric Acid	27-34	fibrinogen beta chain	Homo sapiens	66-76
3343546-6	1988	Exposure of PNB to varying citrate concentrations showed enhanced fibrinogen binding with increasing citrate concentrations; differences in the Kd values between non-citrate-treated PNB and citrate-treated PNB were apparent at about 7.5 mmol/L of citrate.	Citric Acid	101-108	fibrinogen beta chain	Homo sapiens	66-76
3343546-6	1988	Exposure of PNB to varying citrate concentrations showed enhanced fibrinogen binding with increasing citrate concentrations; differences in the Kd values between non-citrate-treated PNB and citrate-treated PNB were apparent at about 7.5 mmol/L of citrate.	Citric Acid	101-108	fibrinogen beta chain	Homo sapiens	66-76
3343546-6	1988	Exposure of PNB to varying citrate concentrations showed enhanced fibrinogen binding with increasing citrate concentrations; differences in the Kd values between non-citrate-treated PNB and citrate-treated PNB were apparent at about 7.5 mmol/L of citrate.	Citric Acid	101-108	fibrinogen beta chain	Homo sapiens	66-76
3343546-6	1988	Exposure of PNB to varying citrate concentrations showed enhanced fibrinogen binding with increasing citrate concentrations; differences in the Kd values between non-citrate-treated PNB and citrate-treated PNB were apparent at about 7.5 mmol/L of citrate.	Citric Acid	101-108	fibrinogen beta chain	Homo sapiens	66-76
3343546-7	1988	The effects of citrate in increasing the association of fibrinogen with platelets were not caused by variations in the pH; although fibrinogen binding was diminished at low pH of the citrate used, more binding was observed in the presence of citrate than with buffer of the same pH.	Citric Acid	15-22	fibrinogen beta chain	Homo sapiens	56-66
3343546-7	1988	The effects of citrate in increasing the association of fibrinogen with platelets were not caused by variations in the pH; although fibrinogen binding was diminished at low pH of the citrate used, more binding was observed in the presence of citrate than with buffer of the same pH.	Citric Acid	183-190	fibrinogen beta chain	Homo sapiens	132-142
3343546-7	1988	The effects of citrate in increasing the association of fibrinogen with platelets were not caused by variations in the pH; although fibrinogen binding was diminished at low pH of the citrate used, more binding was observed in the presence of citrate than with buffer of the same pH.	Citric Acid	183-190	fibrinogen beta chain	Homo sapiens	132-142
3343546-8	1988	The effects of citrate appear to be on the platelet fibrinogen receptor because nonspecific binding was not affected by the citrate.	Citric Acid	15-22	fibrinogen beta chain	Homo sapiens	52-62
3343546-9	1988	Inasmuch as no carbon 14-labeled citric acid binding to platelets was observed, citrate may affect the platelet-fibrinogen interactions without binding to the platelets.	Citric Acid	80-87	fibrinogen beta chain	Homo sapiens	112-122
3343546-10	1988	We conclude that platelet exposure to citrate increases the fibrinogen binding and may lead to the appearance of curved Scatchard plots.	Citric Acid	38-45	fibrinogen beta chain	Homo sapiens	60-70
3323644-1	1987	Myoadenylate deaminase (MAD) is the rate-limiting enzyme in the purine nucleotide cycle which is biochemically linked to glycolysis and the citric cycle and thereby providing energy during intense muscular activity.	Citric Acid	140-146	adenosine monophosphate deaminase 3	Homo sapiens	0-22
3257395-4	1988	The complete extraction of the enzyme activity is never observed when, at pH 5.0, the acetate is replaced by glutamate, citrate, succinate or maleate and only 45% and 15% of the adenosine deaminase activity is extracted by the acetate at pH 6.0 and 7.0, respectively.	Citric Acid	120-127	adenosine deaminase	Mus musculus	178-197
3384677-2	1988	Both 199Au and 195Au complex anions in citrate-buffered solutions (pH 3.8-7.2) are rapidly bound to sheep polyclonal anti-CEA with high efficiency.	Citric Acid	39-46	CEA cell adhesion molecule 3	Homo sapiens	122-125
3142152-2	1988	Loss of VIII:C over process-finishing procedures (formulation, 0.22 micron filtration, dispensing) was associated with a citrate-induced inactivation which could be prevented by controlling the ionised calcium concentration of the solution.	Citric Acid	121-128	cytochrome c oxidase subunit 8A	Homo sapiens	8-12
2826495-1	1987	Small bipolar filaments, or "minifilaments," are formed when smooth muscle myosin is dialyzed against low ionic strength pyrophosphate or citrate/Tris buffers.	Citric Acid	138-145	myosin heavy chain 14	Homo sapiens	75-81
3323644-1	1987	Myoadenylate deaminase (MAD) is the rate-limiting enzyme in the purine nucleotide cycle which is biochemically linked to glycolysis and the citric cycle and thereby providing energy during intense muscular activity.	Citric Acid	140-146	adenosine monophosphate deaminase 3	Homo sapiens	24-27
3681974-1	1987	Electron microscopic observations of negatively stained myosin minifilaments in a solution containing 10 mM-citrate buffer (pH 8.0), 4 mM-MgCl2 reveal ordered assemblies.	Citric Acid	107-115	myosin heavy chain 14	Homo sapiens	56-62
2452210-2	1988	Furthermore, with conventional uranyl acetate and lead citrate stains, the elastin matrix remains electron-lucent so that even severe elastosis is elusive.	Citric Acid	55-62	elastin	Mus musculus	75-82
3325498-1	1987	When baker"s yeast grown aerobically on ethanol as a carbon source was anaerobically cultured in a medium containing glucose, the activity of a cytoplasmic fumarate reductase irreversibly catalyzing the conversion of fumarate to succinate increased, reaching about 3 times the original activity after 12 h, while the activity of succinate dehydrogenase was almost lost after 10 h. These results indicate that the citrate cycle is partially modified to become a reductive pathway leading to succinate during the anaerobic cultivation.	Citric Acid	413-420	fumarate reductase	Saccharomyces cerevisiae S288C	156-174
3553333-13	1987	C1-INH antigenic concentrations were measured and shown to be correlated in serum, citrate plasma, and EDTA plasma from 16 normal subjects.	Citric Acid	83-90	serpin family G member 1	Homo sapiens	0-6
3603581-9	1987	Pb2+ was a more effective inhibitor of delta-aminolevulinic acid dehydratase (ALA-d) activity in MES buffer than in citrate buffer, possibly because of chelation of Pb2+ by citrate.	Citric Acid	173-180	aminolevulinate dehydratase	Homo sapiens	39-76
3603581-9	1987	Pb2+ was a more effective inhibitor of delta-aminolevulinic acid dehydratase (ALA-d) activity in MES buffer than in citrate buffer, possibly because of chelation of Pb2+ by citrate.	Citric Acid	173-180	aminolevulinate dehydratase	Homo sapiens	78-83
3114026-0	1987	Independent control of citrate production and ornithine decarboxylase by prolactin in the lateral lobe of the rat prostate.	Citric Acid	23-30	prolactin	Rattus norvegicus	73-82
3114026-1	1987	Prolactin stimulated the citric acid content of the lateral lobe of the prostate of androgenized-hypophysectomized rats in a time-dependent manner.	Citric Acid	25-36	prolactin	Rattus norvegicus	0-9
3114026-2	1987	This stimulation of citric acid levels was not blocked by pretreatment of the animals with the ornithine decarboxylase (ODC) inhibitor, alpha-difluoromethyl ornithine (DFMO), suggesting that the prolactin induction of citric acid in this organ is not mediated through activation of the ODC.	Citric Acid	20-31	prolactin	Rattus norvegicus	195-204
3114026-6	1987	Both studies suggest that although citric acid and ODC are modulated by prolactin, their synthesis or activation are controlled independently of each other.	Citric Acid	35-46	prolactin	Rattus norvegicus	72-81
3606854-10	1987	HTr) using the citrate method invariably contained 2.2-2.4 atoms Fe/molecule, whereas Fe .	Citric Acid	15-22	telomerase RNA component	Homo sapiens	0-3
3108440-6	1987	Incubation of human luteal tissue with ice-cold citrate buffer (pH 3) released more than 90% of specifically bound 125I-labelled hCG within 5 min.	Citric Acid	48-55	chorionic gonadotropin subunit beta 5	Homo sapiens	129-132
3606854-14	1987	HTr (citrate) than from 55Fe .	Citric Acid	5-12	telomerase RNA component	Homo sapiens	0-3
3606854-20	1987	HTr (citrate), respectively.	Citric Acid	5-12	telomerase RNA component	Homo sapiens	0-3
3026789-6	1987	Addition of lipase and protease inhibitors to the citrate buffer or fasting the animals before death increase the active Ca2+ transport rates in BLM from -D rats to control levels.	Citric Acid	50-57	lipase G, endothelial type	Rattus norvegicus	12-18
3815806-4	1987	When the concentration of total Al3+ in plasma is 1 mumol/L, the free Al3+ concentration permitted by transferrin is 10(-14.6) mol/L, less than that allowed by insoluble Al(OH)3, by Al(OH)2H2PO4, or by complexing with citrate.	Citric Acid	218-225	transferrin	Homo sapiens	102-113
3658826-0	1987	Interaction of sex steroids and prolactin on phosphatases, transaminases, and citric acid in the ventral prostate of male albino rats.	Citric Acid	78-89	prolactin	Rattus norvegicus	32-41
3449140-2	1987	Further blood perfusion through SKN-D hemosorbent allowed to reduce the following adenine level to zero; riboxine by 90; citrate and lactate by 50%.	Citric Acid	121-128	hedgehog acyltransferase	Homo sapiens	32-35
3436479-4	1987	As involution progressed, somatic cell counts, percent protein, pH, and concentrations of serum albumin, lactoferrin, and immunoglobulin G increased while percent fat, concentrations of citrate, and the citrate to lactoferrin molar ratio decreased.	Citric Acid	203-210	lactotransferrin	Bos taurus	214-225
3332990-1	1987	Three key dehydrogenases in the mitochondria of higher animals have been found to be activated by Ca2+ ions; these are pyruvate dehydrogenase and two enzymes in the citric acid cycle, NAD-isocitrate dehydrogenase and oxoglutarate dehydrogenase.	Citric Acid	165-176	oxoglutarate dehydrogenase	Homo sapiens	217-243
3332992-5	1987	From affinity chromatographic experiments, we have shown that the enzymes of the citric acid cycle and the aspartate-malate shuttle are organized as one huge multi-enzyme complex, and a stoichiometric arrangement of fumarase/malate dehydrogenase/citrate synthase/aspartate aminotransferase has been postulated.	Citric Acid	81-92	fumarate hydratase	Homo sapiens	216-224
3332992-5	1987	From affinity chromatographic experiments, we have shown that the enzymes of the citric acid cycle and the aspartate-malate shuttle are organized as one huge multi-enzyme complex, and a stoichiometric arrangement of fumarase/malate dehydrogenase/citrate synthase/aspartate aminotransferase has been postulated.	Citric Acid	81-92	malic enzyme 1	Homo sapiens	225-245
3332992-5	1987	From affinity chromatographic experiments, we have shown that the enzymes of the citric acid cycle and the aspartate-malate shuttle are organized as one huge multi-enzyme complex, and a stoichiometric arrangement of fumarase/malate dehydrogenase/citrate synthase/aspartate aminotransferase has been postulated.	Citric Acid	81-92	citrate synthase	Homo sapiens	246-262
3658826-6	1987	The synergistic effect of PRL with androgens was observed in the adult ventral prostatic secretory acid phosphatase and citric acid.	Citric Acid	120-131	prolactin	Rattus norvegicus	26-29
3806090-5	1986	Ignoring the likely occurrence of a competing 2:1 citrate-Fe3+ complex necessitates adjustments in reported stability constants for Fe3+ binding to transferrin.	Citric Acid	50-57	transferrin	Homo sapiens	148-159
3778666-15	1986	However, the addition of trisodium citrate to Fe.HTr (ceruloplasmin) caused a reduction in absorbance at 465 nm and a change in ESR profile to resemble that of Fe.HTr (citrate) after dialysis in H2O; these changes, caused by citrate binding to Fe.HTr (ceruloplasmin), were restored to normal by the addition of Na2CO3.	Citric Acid	35-42	telomerase RNA component	Homo sapiens	49-52
3492437-13	1986	About 75% of the amount of glutamate derived from glutamine entered into the citric acid cycle via the aspartate aminotransferase, and the remaining 25% via the glutamate dehydrogenase reaction.	Citric Acid	77-88	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	103-129
3768349-1	1986	Magnetic birefringence is used to monitor the kinetics of thrombin-catalyzed fibrin polymerization in model systems of increasing complexity (i.e., fibrinogen solutions, fibrinogen/albumin mixtures, and plasma anticoagulated with citrate) and in plasma containing free calcium which is the physiological condition.	Citric Acid	230-237	coagulation factor II, thrombin	Homo sapiens	58-66
3778666-6	1986	Ion-exchange chromatography of 55Fe.HTr (citrate) did not induce loss of 55Fe.	Citric Acid	41-48	telomerase RNA component	Homo sapiens	36-39
3778666-8	1986	Using an excitation wavelength of 275 nm, the fluorescence intensity ratios relative to apo.HTr were 0.275 and 0.309 for Fe.HTr (citrate) and Fe.HTr (ceruloplasmin), respectively.	Citric Acid	129-136	telomerase RNA component	Homo sapiens	92-95
3778666-15	1986	However, the addition of trisodium citrate to Fe.HTr (ceruloplasmin) caused a reduction in absorbance at 465 nm and a change in ESR profile to resemble that of Fe.HTr (citrate) after dialysis in H2O; these changes, caused by citrate binding to Fe.HTr (ceruloplasmin), were restored to normal by the addition of Na2CO3.	Citric Acid	35-42	ceruloplasmin	Homo sapiens	54-67
3778666-9	1986	Electron spin resonance (ESR) measurements confirmed that Fe.HTr (citrate) and Fe.HTr (ceruloplasmin) were saturated with Fe.	Citric Acid	66-73	telomerase RNA component	Homo sapiens	61-64
3778666-11	1986	Dialysis against H2O caused Fe.HTr (citrate), but not Fe.HTr (ceruloplasmin), to lose absorbance at 465 nm.	Citric Acid	36-43	telomerase RNA component	Homo sapiens	31-34
3778666-15	1986	However, the addition of trisodium citrate to Fe.HTr (ceruloplasmin) caused a reduction in absorbance at 465 nm and a change in ESR profile to resemble that of Fe.HTr (citrate) after dialysis in H2O; these changes, caused by citrate binding to Fe.HTr (ceruloplasmin), were restored to normal by the addition of Na2CO3.	Citric Acid	35-42	telomerase RNA component	Homo sapiens	163-166
3778666-12	1986	The ESR profile of Fe.HTr (citrate), after dialysis against H2O, was reduced to multiple splittings and a lack of resolution of the central hyperfine structure.	Citric Acid	27-34	telomerase RNA component	Homo sapiens	22-25
3778666-13	1986	Addition of Na2CO3 restored the absorbance (465 nm) and the ESR pattern of Fe.HTr (citrate).	Citric Acid	83-90	telomerase RNA component	Homo sapiens	78-81
3778666-15	1986	However, the addition of trisodium citrate to Fe.HTr (ceruloplasmin) caused a reduction in absorbance at 465 nm and a change in ESR profile to resemble that of Fe.HTr (citrate) after dialysis in H2O; these changes, caused by citrate binding to Fe.HTr (ceruloplasmin), were restored to normal by the addition of Na2CO3.	Citric Acid	35-42	telomerase RNA component	Homo sapiens	163-166
3778666-15	1986	However, the addition of trisodium citrate to Fe.HTr (ceruloplasmin) caused a reduction in absorbance at 465 nm and a change in ESR profile to resemble that of Fe.HTr (citrate) after dialysis in H2O; these changes, caused by citrate binding to Fe.HTr (ceruloplasmin), were restored to normal by the addition of Na2CO3.	Citric Acid	35-42	ceruloplasmin	Homo sapiens	252-265
3778666-15	1986	However, the addition of trisodium citrate to Fe.HTr (ceruloplasmin) caused a reduction in absorbance at 465 nm and a change in ESR profile to resemble that of Fe.HTr (citrate) after dialysis in H2O; these changes, caused by citrate binding to Fe.HTr (ceruloplasmin), were restored to normal by the addition of Na2CO3.	Citric Acid	168-175	telomerase RNA component	Homo sapiens	49-52
3778666-15	1986	However, the addition of trisodium citrate to Fe.HTr (ceruloplasmin) caused a reduction in absorbance at 465 nm and a change in ESR profile to resemble that of Fe.HTr (citrate) after dialysis in H2O; these changes, caused by citrate binding to Fe.HTr (ceruloplasmin), were restored to normal by the addition of Na2CO3.	Citric Acid	168-175	ceruloplasmin	Homo sapiens	54-67
3778666-15	1986	However, the addition of trisodium citrate to Fe.HTr (ceruloplasmin) caused a reduction in absorbance at 465 nm and a change in ESR profile to resemble that of Fe.HTr (citrate) after dialysis in H2O; these changes, caused by citrate binding to Fe.HTr (ceruloplasmin), were restored to normal by the addition of Na2CO3.	Citric Acid	168-175	telomerase RNA component	Homo sapiens	163-166
3778666-15	1986	However, the addition of trisodium citrate to Fe.HTr (ceruloplasmin) caused a reduction in absorbance at 465 nm and a change in ESR profile to resemble that of Fe.HTr (citrate) after dialysis in H2O; these changes, caused by citrate binding to Fe.HTr (ceruloplasmin), were restored to normal by the addition of Na2CO3.	Citric Acid	168-175	telomerase RNA component	Homo sapiens	163-166
3748680-7	1986	Milk samples from ruminants were found to have concentrations of hydrogen ions and citrate that are greater than and pH that is less than the respective measurements in human milk.	Citric Acid	83-90	Weaning weight-maternal milk	Bos taurus	0-4
2946386-7	1986	However, genetic factors appear to be involved in the variation of regulatory enzymes of the glycolytic (PFK) and citric acid cycle (OGDH) pathways and in the variation of the oxidative to glycolytic activity ratio (PFK/OGDH ratio).	Citric Acid	114-125	oxoglutarate dehydrogenase	Homo sapiens	133-137
3748680-0	1986	Relationship of human milk pH during course of lactation to concentrations of citrate and fatty acids.	Citric Acid	78-85	Weaning weight-maternal milk	Bos taurus	22-26
3748680-4	1986	The change in hydrogen ion concentration in milk was associated with corresponding changes throughout lactation in the concentration of citrate but not with the concentration of lactose.	Citric Acid	136-143	Weaning weight-maternal milk	Bos taurus	44-48
3095944-5	1986	Mean fibrinogen levels at the end of the infusions of 40 mg or 60 mg rt-PA over 90 min, measured in thawed plasma samples collected on citrate/aprotinin, decreased to 74% and 57% of the preinfusion values respectively.	Citric Acid	135-142	fibrinogen beta chain	Homo sapiens	5-15
3776117-2	1986	The liver enzyme as well as the callus citrate synthase were responsible for high rate of lipogenesis (activation of ATP-citrate lyase) and for an increase in content of citric acid within the initial period of consolidation.	Citric Acid	170-181	citrate synthase	Rattus norvegicus	39-55
3738860-1	1986	When human citrated plasma is dialysed against a phosphate buffer containing Ca++, citrate anions are removed, thrombin is generated and soluble fibrinogen derivatives (fibrin monomers and/or soluble fibrin polymers) are formed.	Citric Acid	11-18	coagulation factor II, thrombin	Homo sapiens	111-119
2942107-3	1986	For both PFK homologs, carbethoxylation reduces the sensitivity to ATP and citrate inhibition, the cooperativity as a function of fructose 6-phosphate concentration and the degree of activation in the presence ADP, AMP, and fructose 2,6-bisphosphate.	Citric Acid	75-82	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	9-12
3738860-1	1986	When human citrated plasma is dialysed against a phosphate buffer containing Ca++, citrate anions are removed, thrombin is generated and soluble fibrinogen derivatives (fibrin monomers and/or soluble fibrin polymers) are formed.	Citric Acid	11-18	fibrinogen beta chain	Homo sapiens	145-155
3738862-1	1986	The changes that take place when a therapeutic antithrombin III (AT III) concentrate is heated in the presence of citrate ion have been assessed.	Citric Acid	114-121	serpin family C member 1	Homo sapiens	47-63
3738862-1	1986	The changes that take place when a therapeutic antithrombin III (AT III) concentrate is heated in the presence of citrate ion have been assessed.	Citric Acid	114-121	serpin family C member 1	Homo sapiens	65-71
3087006-4	1986	Differences between citrate-PRP and heparin-PRP are probably due to citrate inhibition of platelet aggregation, since addition of citrate to heparin-PRP decreased aggregation, while addition of heparin to citrate-PRP did not alter aggregation.	Citric Acid	20-27	proline rich protein 2-like 1	Rattus norvegicus	28-31
3521681-9	1986	Muscle PEPCK activity was also increased during exercise suggesting an increased rate of conversion of oxaloacetate to pyruvate to provide net oxidation of oxaloacetate and other citric acid cycle intermediates.	Citric Acid	179-190	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	7-12
3087006-1	1986	Aggregation of platelets in heparin- and citrate-anticoagulated platelet-rich-plasma (PRP) from rats anesthetized with methoxyflurane (M), diethyl ether (E), acepromazine/ketamine (A/K), or sodium pentobarbital (P) is described, as are platelet counts.	Citric Acid	41-48	proline rich protein 2-like 1	Rattus norvegicus	64-84
3087006-1	1986	Aggregation of platelets in heparin- and citrate-anticoagulated platelet-rich-plasma (PRP) from rats anesthetized with methoxyflurane (M), diethyl ether (E), acepromazine/ketamine (A/K), or sodium pentobarbital (P) is described, as are platelet counts.	Citric Acid	41-48	proline rich protein 2-like 1	Rattus norvegicus	86-89
3087006-4	1986	Differences between citrate-PRP and heparin-PRP are probably due to citrate inhibition of platelet aggregation, since addition of citrate to heparin-PRP decreased aggregation, while addition of heparin to citrate-PRP did not alter aggregation.	Citric Acid	68-75	proline rich protein 2-like 1	Rattus norvegicus	44-47
3087006-2	1986	Platelet counts were highest in heparin- or citrate-PRP from E and A/K anesthetized rats.	Citric Acid	44-51	proline rich protein 2-like 1	Rattus norvegicus	52-55
3087006-4	1986	Differences between citrate-PRP and heparin-PRP are probably due to citrate inhibition of platelet aggregation, since addition of citrate to heparin-PRP decreased aggregation, while addition of heparin to citrate-PRP did not alter aggregation.	Citric Acid	68-75	proline rich protein 2-like 1	Rattus norvegicus	44-47
3087006-4	1986	Differences between citrate-PRP and heparin-PRP are probably due to citrate inhibition of platelet aggregation, since addition of citrate to heparin-PRP decreased aggregation, while addition of heparin to citrate-PRP did not alter aggregation.	Citric Acid	68-75	proline rich protein 2-like 1	Rattus norvegicus	44-47
3087006-4	1986	Differences between citrate-PRP and heparin-PRP are probably due to citrate inhibition of platelet aggregation, since addition of citrate to heparin-PRP decreased aggregation, while addition of heparin to citrate-PRP did not alter aggregation.	Citric Acid	68-75	proline rich protein 2-like 1	Rattus norvegicus	44-47
3087006-4	1986	Differences between citrate-PRP and heparin-PRP are probably due to citrate inhibition of platelet aggregation, since addition of citrate to heparin-PRP decreased aggregation, while addition of heparin to citrate-PRP did not alter aggregation.	Citric Acid	68-75	proline rich protein 2-like 1	Rattus norvegicus	44-47
3087006-4	1986	Differences between citrate-PRP and heparin-PRP are probably due to citrate inhibition of platelet aggregation, since addition of citrate to heparin-PRP decreased aggregation, while addition of heparin to citrate-PRP did not alter aggregation.	Citric Acid	68-75	proline rich protein 2-like 1	Rattus norvegicus	44-47
3087006-4	1986	Differences between citrate-PRP and heparin-PRP are probably due to citrate inhibition of platelet aggregation, since addition of citrate to heparin-PRP decreased aggregation, while addition of heparin to citrate-PRP did not alter aggregation.	Citric Acid	68-75	proline rich protein 2-like 1	Rattus norvegicus	44-47
3087006-4	1986	Differences between citrate-PRP and heparin-PRP are probably due to citrate inhibition of platelet aggregation, since addition of citrate to heparin-PRP decreased aggregation, while addition of heparin to citrate-PRP did not alter aggregation.	Citric Acid	68-75	proline rich protein 2-like 1	Rattus norvegicus	44-47
3087006-4	1986	Differences between citrate-PRP and heparin-PRP are probably due to citrate inhibition of platelet aggregation, since addition of citrate to heparin-PRP decreased aggregation, while addition of heparin to citrate-PRP did not alter aggregation.	Citric Acid	68-75	proline rich protein 2-like 1	Rattus norvegicus	44-47
3087006-6	1986	Anesthetics affected rat platelet aggregation: the rank order of the maximal extent of ADP-induced aggregation in citrate-PRP was M greater than E = A/K greater than P, and that for AA and collagen in heparin-PRP was E = A/K greater than M = P. The correlation between the effect of the anesthetics and activation of the sympathoadrenal system is discussed.	Citric Acid	114-121	proline rich protein 2-like 1	Rattus norvegicus	122-125
3087006-6	1986	Anesthetics affected rat platelet aggregation: the rank order of the maximal extent of ADP-induced aggregation in citrate-PRP was M greater than E = A/K greater than P, and that for AA and collagen in heparin-PRP was E = A/K greater than M = P. The correlation between the effect of the anesthetics and activation of the sympathoadrenal system is discussed.	Citric Acid	114-121	proline rich protein 2-like 1	Rattus norvegicus	209-212
3949736-4	1986	Oxaloacetate and citrate, substrates for the forward and reverse reaction catalyzed by citrate synthase, affect dimerization at concentrations of the protein which exists as monomer in their absence.	Citric Acid	17-24	citrate synthase	Homo sapiens	87-103
3530729-3	1986	This monoclonal antibody seems to belong to IgG2b as it was eluted from protein A-Sepharose CL-4B with citrate buffer pH 3.5. competitive binding experiment using fragment peptides of LHRH indicated the binding site of LRH13 was a region around serine and tyrosine, and modification of mammalian LHRH by radioiodination caused a marked decrease in the binding activity.	Citric Acid	103-110	gonadotropin releasing hormone 1	Homo sapiens	184-188
3530729-3	1986	This monoclonal antibody seems to belong to IgG2b as it was eluted from protein A-Sepharose CL-4B with citrate buffer pH 3.5. competitive binding experiment using fragment peptides of LHRH indicated the binding site of LRH13 was a region around serine and tyrosine, and modification of mammalian LHRH by radioiodination caused a marked decrease in the binding activity.	Citric Acid	103-110	gonadotropin releasing hormone 1	Homo sapiens	296-300
3085265-1	1986	Factor VIII coagulant activity (VIII:C) has been shown by several investigators to exhibit increased stability in vitro when physiological levels of plasma ionized calcium are maintained by anticoagulation with heparin rather than citrate.	Citric Acid	231-238	cytochrome c oxidase subunit 8A	Homo sapiens	7-11
3085265-1	1986	Factor VIII coagulant activity (VIII:C) has been shown by several investigators to exhibit increased stability in vitro when physiological levels of plasma ionized calcium are maintained by anticoagulation with heparin rather than citrate.	Citric Acid	231-238	cytochrome c oxidase subunit 8A	Homo sapiens	32-36
3085265-2	1986	An increase in initial activity of VIII:C in heparin over that of VIII:C in citrate has been reported but this has not been confirmed.	Citric Acid	76-83	cytochrome c oxidase subunit 8A	Homo sapiens	66-70
3949736-7	1986	In light of recent evidence derived from x-ray crystallographic studies showing amino acid residues from one subunit contributing to the citrate and CoA binding sites of the other, the dissociation into monomers would be expected to have profound effects on citrate synthase activity and regulation, as well as overall tricarboxylic acid cycle activity.	Citric Acid	137-144	citrate synthase	Homo sapiens	258-274
3485450-2	1986	Nevertheless, the presence of nonequivalent bonding interactions within the filament permits differential stabilization of several macromolecular assemblies of myosin under well-controlled ionic conditions in citrate/Tris buffer at pH 8.0.	Citric Acid	209-216	myosin heavy chain 14	Homo sapiens	160-166
3513675-9	1986	A highly significant positive correlation was found between bacterial growth inhibition and concentrations of lactoferrin, serum albumin, and immunoglobulin G. A highly significant negative correlation was found in the citrate:lactoferrin molar ratio during early involution and the peripartum period.	Citric Acid	219-226	lactotransferrin	Bos taurus	227-238
3944416-5	1986	Increasing concentrations of acetate or citrate led to decreasing light scattering of the polyethylene glycol--bovine submaxillary mucin--H. pomatia lectin reaction mixture.	Citric Acid	40-47	mucin 1, cell surface associated	Bos taurus	131-136
2414457-10	1985	Tissue beta-glucuronidase activity was enhanced by either spermidine, spermine, or citrate together with testosterone.	Citric Acid	83-90	glucuronidase beta	Homo sapiens	7-25
3941460-6	1986	citrate had a significant correlation coefficient (lnY = 1.048 X lnX-2.755, r = 0.997).	Citric Acid	0-7	ligand of numb-protein X 2	Rattus norvegicus	65-70
3959117-5	1986	Intraperitoneal administration of citrate (40 mg/100 g body weight) along with FAR significantly reduced FAR-induced increase in hepatic cytochrome P-450 levels and glutathione S-transferase activity.	Citric Acid	34-41	Fs(3)Far	Drosophila melanogaster	105-108
3959117-5	1986	Intraperitoneal administration of citrate (40 mg/100 g body weight) along with FAR significantly reduced FAR-induced increase in hepatic cytochrome P-450 levels and glutathione S-transferase activity.	Citric Acid	34-41	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	137-153
3959117-5	1986	Intraperitoneal administration of citrate (40 mg/100 g body weight) along with FAR significantly reduced FAR-induced increase in hepatic cytochrome P-450 levels and glutathione S-transferase activity.	Citric Acid	34-41	hematopoietic prostaglandin D synthase	Rattus norvegicus	165-190
3509891-5	1986	Stimulated sallivation with citric acid caused a fall in hEGF through a dilution effect.	Citric Acid	28-39	epidermal growth factor	Homo sapiens	57-61
2413926-4	1985	Plasma factor XIII and 125I-factor XIII was bound (89.6% to 92.5%) to fibrin II formed by thrombin in either citrate or EDTA anticoagulated plasma.	Citric Acid	109-116	coagulation factor II, thrombin	Homo sapiens	90-98
3915598-2	1985	The single crystals of this pair of insulin analogue suitable for X-ray diffraction analysis have been grown in the citrate buffer system by still-setting method.	Citric Acid	116-123	insulin	Homo sapiens	36-43
3806090-6	1986	In the blood, plasma transferrin steals both Fe3+ and Al3+ from citrate.	Citric Acid	64-71	transferrin	Homo sapiens	21-32
3931594-12	1985	Shock, sepsis, and multiple transfusions containing citrate may lower total and/or ionized calcium and thus stimulate PTH secretion.	Citric Acid	52-59	parathyroid hormone	Homo sapiens	118-121
2993389-7	1985	The citrate: lactoferrin molar ratio decreased from 1373 to 606.	Citric Acid	4-11	lactotransferrin	Bos taurus	13-24
3903101-9	1985	However, citric acid or phenol-water extracts of diseased cementum shavings (highly endotoxin positive) significantly suppressed HGF growth 58% and 61%, respectively.	Citric Acid	9-20	hepatocyte growth factor	Homo sapiens	129-132
3932188-7	1985	In contrast, after dissociation of C1 or C1 by citrate, 100% of the original C1q activity is recoverable on addition of C1q deficient serum as source of C1r and C1s.	Citric Acid	47-54	complement C1q A chain	Homo sapiens	77-80
4030589-1	1985	Administration of aerosols of citric acid to anesthetized spontaneously breathing hyperreactive rats produced reversible increases in respiratory rate (f) and pleural pressure (Ppl) accompanied by hypotension and bradycardia.	Citric Acid	30-41	periplakin	Rattus norvegicus	177-180
4030589-3	1985	The effects of various treatments on citric acid-induced changes in f, Ppl and blood pressure were studied.	Citric Acid	37-48	periplakin	Rattus norvegicus	71-74
3860519-6	1985	Significantly increased amounts of connective tissue reattachment were observed in the areas treated with the citric acid/fibronectin combination.	Citric Acid	110-121	fibronectin 1	Canis lupus familiaris	122-133
2993389-9	1985	The citrate: lactoferrin molar ratio decreased from 1621 to 1301.	Citric Acid	4-11	lactotransferrin	Bos taurus	13-24
4003387-4	1985	Higher levels of Zn+2 (greater than 0.2 mM final concentration) were required to accelerate thrombin-induced clot formation in the presence of citrate or oxalate.	Citric Acid	143-150	coagulation factor II, thrombin	Homo sapiens	92-100
4008497-7	1985	Thus, MEDICA 16 inhibited liver ATP-citrate lyase competitively to citrate with a Ki of 16 microM as compared to a Km of 0.8 mM for the citrate substrate.	Citric Acid	67-74	ATP citrate lyase	Rattus norvegicus	32-49
3836023-1	1985	The uptake and binding of 59Fe, 67Ga and 239Pu complexed with citrate of transferrin (Tf) and of 125I-labelled Fe-Tf by human lymphoblasts (WI-L2 cells) have been studied.	Citric Acid	62-69	transferrin	Homo sapiens	73-84
3836023-1	1985	The uptake and binding of 59Fe, 67Ga and 239Pu complexed with citrate of transferrin (Tf) and of 125I-labelled Fe-Tf by human lymphoblasts (WI-L2 cells) have been studied.	Citric Acid	62-69	transferrin	Homo sapiens	86-88
4035200-7	1985	Dried Concentrated Antihemophilic Factor and Dried plasma contain citrate which inhibits the reaction.	Citric Acid	66-73	coagulation factor VIII	Homo sapiens	19-40
2861809-10	1985	The amount of glutamate formed by phosphate-dependent glutaminase which entered the citric acid cycle was enhanced 5-fold in the proliferating cells: 76% was converted into 2-oxoglutarate by aspartate aminotransferase, present in high activity, and the remaining 24% by glutamate dehydrogenase.	Citric Acid	84-95	glutaminase	Canis lupus familiaris	54-65
2861809-10	1985	The amount of glutamate formed by phosphate-dependent glutaminase which entered the citric acid cycle was enhanced 5-fold in the proliferating cells: 76% was converted into 2-oxoglutarate by aspartate aminotransferase, present in high activity, and the remaining 24% by glutamate dehydrogenase.	Citric Acid	84-95	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	191-217
2861809-12	1985	Maximal activities of glutaminase, glutamate dehydrogenase and aspartate aminotransferase were increased 3-, 12- and 6-fold respectively in proliferating cells; 32% of the glutamate metabolized in the citric acid cycle was recovered in CO2 and 61% in aspartate.	Citric Acid	201-212	glutaminase	Canis lupus familiaris	22-58
2861809-12	1985	Maximal activities of glutaminase, glutamate dehydrogenase and aspartate aminotransferase were increased 3-, 12- and 6-fold respectively in proliferating cells; 32% of the glutamate metabolized in the citric acid cycle was recovered in CO2 and 61% in aspartate.	Citric Acid	201-212	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	63-89
3985618-2	1985	Using an affinity elution procedure based upon citrate binding to malate dehydrogenase, the isolation of pure heterodimer (a dimeric species with one active subunit and one iodoacetamide-inactivated subunit) has been achieved.	Citric Acid	47-54	malic enzyme 2	Homo sapiens	66-86
3980672-1	1985	To study the relationships between changes in concentrations of different forms of calcium and the responses of immunoreactive PTH in humans during citrate-induced hypocalcemia, we studied 12 healthy donors undergoing continuous flow plateletapheresis.	Citric Acid	148-155	parathyroid hormone	Homo sapiens	127-130
3884090-1	1985	Pyruvate carboxylase is the predominant anaplerotic enzyme in CNS tissues, and thus provides for net utilization of glucose to generate citric acid cycle intermediates such as alpha-ketoglutarate and malate for replenishment of the neurotransmitter pools of glutamate, GABA and aspartate.	Citric Acid	136-147	pyruvate carboxylase	Homo sapiens	0-20
2859813-4	1985	GGTP showed similar relationships with citrate and fructose.	Citric Acid	39-46	inactive glutathione hydrolase 2	Homo sapiens	0-4
3158347-0	1985	Interactions between citrate and nucleoside triphosphates in binding to phosphofructokinase.	Citric Acid	21-28	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	72-91
3158347-1	1985	Interrelationships between the binding by rabbit muscle phosphofructokinase of citrate, ATP, GTP, and adenyl-5"-yl imidodiphosphate (AMP-PNP) were investigated.	Citric Acid	79-86	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	56-75
4018438-2	1985	Citrate is normally secreted in the pancreatic juice and this secretion increases in parallel with protein after CCK injection.	Citric Acid	0-7	cholecystokinin	Homo sapiens	113-116
3983897-1	1985	Fibrinogen was purified from fresh citrated human plasma by precipitation with beta-alanine in the presence of citrate and protease inhibitors.	Citric Acid	35-42	fibrinogen beta chain	Homo sapiens	0-10
3997374-5	1985	CIT clearance correlated well with GFR above 50 ml/min/1.73 m2.	Citric Acid	0-3	CD59 molecule (CD59 blood group)	Homo sapiens	51-56
3997374-6	1985	At lower levels, percent tubular reabsorption of CIT decreased rapidly, reaching levels between 17% and 41% at GFR less than 10 ml/min/1.73 m2; this disproportionate fall might be related to reduced renal CIT utilization at a relatively early stage of renal insufficiency.	Citric Acid	49-52	CD59 molecule (CD59 blood group)	Homo sapiens	131-136
3983905-1	1985	Human plasma fibronectin prepared by elution of the adsorbed protein from gelatin-agarose by pH 5.5 citrate buffer is very low in hemagglutinating activity toward trypsinized rabbit erythrocytes, an activity previously associated with the purified plasma protein.	Citric Acid	100-107	fibronectin 1	Homo sapiens	13-24
6325518-8	1984	Addition of increasing concentrations of citrate (2.0 mg/ml) to an assay system containing apo-lactoferrin (5 mg/ml) resulted in a concomitant reduction of growth inhibition of three coliform strains.	Citric Acid	41-48	lactotransferrin	Bos taurus	95-106
6588129-4	1984	The ratio between two citrate cycle enzymes, fumarase and CS, was 4- or 5-fold higher in proximal segments than in the glomerulus or thin limb areas.	Citric Acid	22-29	fumarate hydratase	Rattus norvegicus	45-53
6588129-4	1984	The ratio between two citrate cycle enzymes, fumarase and CS, was 4- or 5-fold higher in proximal segments than in the glomerulus or thin limb areas.	Citric Acid	22-29	citrate synthase	Rattus norvegicus	58-60
6426525-5	1984	In fact, when antithrombin III was pasteurized in the presence of 2 M glucose and 0.5 M citrate, it steadily lost its ability to inhibit thrombin even though Td under these conditions was 10 degrees C higher than in citrate alone where activity was preserved.	Citric Acid	88-95	serpin family C member 1	Homo sapiens	14-30
6426525-5	1984	In fact, when antithrombin III was pasteurized in the presence of 2 M glucose and 0.5 M citrate, it steadily lost its ability to inhibit thrombin even though Td under these conditions was 10 degrees C higher than in citrate alone where activity was preserved.	Citric Acid	88-95	coagulation factor II, thrombin	Homo sapiens	18-26
6426525-5	1984	In fact, when antithrombin III was pasteurized in the presence of 2 M glucose and 0.5 M citrate, it steadily lost its ability to inhibit thrombin even though Td under these conditions was 10 degrees C higher than in citrate alone where activity was preserved.	Citric Acid	216-223	serpin family C member 1	Homo sapiens	14-30
6426525-5	1984	In fact, when antithrombin III was pasteurized in the presence of 2 M glucose and 0.5 M citrate, it steadily lost its ability to inhibit thrombin even though Td under these conditions was 10 degrees C higher than in citrate alone where activity was preserved.	Citric Acid	216-223	coagulation factor II, thrombin	Homo sapiens	18-26
3992968-2	1985	Fn was pasteurized (60 degrees C, 10 h) in the presence of either citrate, tricarballylate, sucrose or four mixtures of lysine, glucarate, gluconate or citrate which had been found to increase the denaturation temperature of Fn by greater than or equal to 19 degrees C. All but a citrate/gluconate mixture were effective in preventing aggregation as measured by dye fluorescence, light scattering, gel filtration and electrophoresis.	Citric Acid	66-73	fibronectin 1	Homo sapiens	0-2
6096166-3	1984	Phosphate also enhances the inactivation of PFK2 by citrate, suggesting that phosphate acts as a regulator of PFK2.	Citric Acid	52-59	6-phosphofructokinase subunit beta	Saccharomyces cerevisiae S288C	44-48
6096166-3	1984	Phosphate also enhances the inactivation of PFK2 by citrate, suggesting that phosphate acts as a regulator of PFK2.	Citric Acid	52-59	6-phosphofructokinase subunit beta	Saccharomyces cerevisiae S288C	110-114
6477932-5	1984	For association of citrate with Co2+ under the assay conditions, KCo-cit was determined as (5.3 +/- 1.4) X 10(3) M-1 by anodic stripping polarography.	Citric Acid	19-26	complement C2	Homo sapiens	32-35
6714171-8	1984	Incubation in the presence of PTH-(1-34) (100 ng/ml) resulted in significant decrease in alkaline phosphatase activity, collagen synthesis, and citrate decarboxylation after 24 h of exposure (P less than 0.001).	Citric Acid	144-151	parathyroid hormone	Rattus norvegicus	30-33
6729777-4	1984	Treatment of plasma with neuraminidase largely abolished the inhibitory effect of excess citrate, and the thrombin times and clot opacity of asialofibrinogen were less affected by citrate than native fibrinogen.	Citric Acid	89-96	neuraminidase 1	Homo sapiens	25-38
6729777-4	1984	Treatment of plasma with neuraminidase largely abolished the inhibitory effect of excess citrate, and the thrombin times and clot opacity of asialofibrinogen were less affected by citrate than native fibrinogen.	Citric Acid	180-187	coagulation factor II, thrombin	Homo sapiens	106-114
6729777-4	1984	Treatment of plasma with neuraminidase largely abolished the inhibitory effect of excess citrate, and the thrombin times and clot opacity of asialofibrinogen were less affected by citrate than native fibrinogen.	Citric Acid	180-187	fibrinogen beta chain	Homo sapiens	147-157
6729777-5	1984	In addition, the effects of citrate on the clotting of purified, calcium-free fibrinogen from cirrhotic patients correlated with the sialic acid content.	Citric Acid	28-35	fibrinogen beta chain	Homo sapiens	78-88
6729777-6	1984	It is concluded that binding of citrate ions to fibrinogen renders the molecule acutely more sensitive to elevations in the sialic acid content, and that a simple plasma clot opacity test in the presence of excess citrate may be a useful aid in the differential diagnosis of liver disease.	Citric Acid	32-39	fibrinogen beta chain	Homo sapiens	48-58
6325518-9	1984	These data indicate a potential relationship between the molar ratio of citrate to lactoferrin of the lacteal secretion and its capacity to inhibit coliform strains associated with mastitis.	Citric Acid	72-79	lactotransferrin	Bos taurus	83-94
6704128-1	1984	At a molar excess of 10:1 for [citrate]/[calmodulin], citrate can prevent aluminum binding to calmodulin when present in the protein solution in micromolar concentration, as determined by fluorescence and circular dichroism spectroscopy.	Citric Acid	54-61	calmodulin 1	Homo sapiens	41-51
6704128-1	1984	At a molar excess of 10:1 for [citrate]/[calmodulin], citrate can prevent aluminum binding to calmodulin when present in the protein solution in micromolar concentration, as determined by fluorescence and circular dichroism spectroscopy.	Citric Acid	54-61	calmodulin 1	Homo sapiens	94-104
6704128-2	1984	In contrast, citrate is only partially effective in restoring calmodulin to its native structure once the aluminum-calmodulin complex (3:1) is formed, as measured by the alpha-helix content of the protein.	Citric Acid	13-20	calmodulin 1	Homo sapiens	62-72
6734667-3	1984	Apotransferrin inhibited the binding of 67Ga to ferritin, especially in the presence of sodium bicarbonate and citrate, thus indicating that 67Ga has not gained access to ferritin from its complex with transferrin.	Citric Acid	111-118	transferrin	Rattus norvegicus	3-14
6704128-2	1984	In contrast, citrate is only partially effective in restoring calmodulin to its native structure once the aluminum-calmodulin complex (3:1) is formed, as measured by the alpha-helix content of the protein.	Citric Acid	13-20	calmodulin 1	Homo sapiens	115-125
6704128-3	1984	Considering the magnitude of the stability constant of the citrate-aluminum chelate, citrate and perhaps other carboxylic acids may protect calmodulin, and thus cells, from toxic aluminum ions.	Citric Acid	59-66	calmodulin 1	Homo sapiens	140-150
6704128-3	1984	Considering the magnitude of the stability constant of the citrate-aluminum chelate, citrate and perhaps other carboxylic acids may protect calmodulin, and thus cells, from toxic aluminum ions.	Citric Acid	85-92	calmodulin 1	Homo sapiens	140-150
6544194-0	1984	The effects of citrate on fMLP-induced polymorphonuclear leukocyte stimulation and locomotion.	Citric Acid	15-22	formyl peptide receptor 1	Homo sapiens	26-30
6544194-4	1984	Citrate (12 mM) partially inhibits fMLP stimulation of the respiratory burst (50%) and degranulation (65%) of PMNs in a divalent cation free media, while having no effect or only a small effect in the presence of 1 mm Ca2+.	Citric Acid	0-7	formyl peptide receptor 1	Homo sapiens	35-39
6544194-5	1984	Citrate also caused significant inhibition of fMLP (12 mM = 50%) induced locomotion of PMN when incubated in media containing 500 microM Ca2+ and 600 microM Mg2+ in a modified Boyden chamber.	Citric Acid	0-7	formyl peptide receptor 1	Homo sapiens	46-50
6544194-7	1984	Citrate apparently inhibits fMLP-induced stimulation in cation free media by chelating CA2+ effluxed from intracellular storage sites.	Citric Acid	0-7	formyl peptide receptor 1	Homo sapiens	28-32
6734667-5	1984	The release of 59Fe from its transferrin complex was enhanced by ATP, citrate, or ascorbic acid, while these reagents did not stimulate the dissociation of 67Ga from its transferrin complex.	Citric Acid	70-77	transferrin	Rattus norvegicus	29-40
6469101-5	1984	As the use of PLP in the citrate tube decreased the heparin neutralization to a negligible effect, PLP-citrate tubes are to be preferred for all plasma heparin determinations.	Citric Acid	25-32	pyridoxal phosphatase	Homo sapiens	14-17
6489730-4	1984	Acid treatment on bone powders in low concentration such as 10 mM of citric acid enhanced [125I]fibronectin binding.	Citric Acid	69-80	fibronectin 1	Homo sapiens	96-107
6469101-5	1984	As the use of PLP in the citrate tube decreased the heparin neutralization to a negligible effect, PLP-citrate tubes are to be preferred for all plasma heparin determinations.	Citric Acid	103-110	pyridoxal phosphatase	Homo sapiens	99-102
6141745-3	1983	The two enzyme activities showed a positive correlation and GGTP activity was significantly correlated with sperm number and citrate concentration.	Citric Acid	125-132	inactive glutathione hydrolase 2	Homo sapiens	60-64
6138356-10	1983	Free citrate is the species responsible for polymerizing the enzyme and Mg2+ causes depolymerization of the enzyme by lowering the concentration of free citrate.	Citric Acid	153-160	mucin 7, secreted	Homo sapiens	72-75
6226805-4	1983	Chicken myosin also assembles into highly homogeneous minifilaments similar to those formed by rabbit myosin in a citrate/Tris buffer.	Citric Acid	114-121	myosin, heavy chain 15	Gallus gallus	8-14
6414552-3	1983	Collection of blood in heparin, instead of chelating anticoagulants, or neutralization of citrate by addition of CaCl2 to heparinized citrate phosphate dextrose (CPD) plasma rendered VIII:C noticeably stable.	Citric Acid	90-97	cytochrome c oxidase subunit 8A	Homo sapiens	183-187
6649022-6	1983	The carboxyl-terminal parathyroid hormone response varied among different donors, but on the average, decreased slightly before gradually rising during the citrate-induced hypocalcemia.	Citric Acid	156-163	parathyroid hormone	Homo sapiens	22-41
6415848-5	1983	The VIII:CAg amount detected in the internal volume increased following the series heparin less than citrate less than EDTA.	Citric Acid	101-108	cytochrome c oxidase subunit 8A	Homo sapiens	4-8
6412352-5	1983	Thrombin induced MDA production was considerably higher in EDTA than in citrate plasma.	Citric Acid	72-79	coagulation factor II, thrombin	Homo sapiens	0-8
6308639-3	1983	Our studies show that the environment of one iron site (Fea) of the [4Fe-4S] cluster is drastically altered in the presence of citrate.	Citric Acid	127-134	FEA	Homo sapiens	56-59
6573370-3	1983	The concentration of lysozyme was three times higher in the submandibular-sublingual than in the parotid secretion, and was significantly higher in unstimulated submandibular saliva than in secretions stimulated with 1, 2, or 4% citric acid.	Citric Acid	229-240	lysozyme	Homo sapiens	21-29
6307150-9	1983	In OB cells, PTH induced significant decreases in citrate decarboxylation at 0.1 nM, compared to 250 nM for PGE1.	Citric Acid	50-57	parathyroid hormone	Bos taurus	13-16
6307150-10	1983	Half-maximal inhibition of citrate decarboxylation (19% of control) by PTH occurred at 0.5 nM, whereas 500 nM of PGE1 was required for an equivalent effect.	Citric Acid	27-34	parathyroid hormone	Bos taurus	71-74
6311371-5	1983	In addition, PTH-induced decrease in citrate decarboxylation was inhibited by low doses of TFP, an inhibitor of calmodulin and calcium-dependent, phospholipid-sensitive protein kinases, in contrast to 1,25(OH)2D3, whose effects were not reduced by this agent.	Citric Acid	37-44	inhibitor of carbonic anhydrase pseudogene	Homo sapiens	91-94
6343501-4	1983	We have modified the buffer by the addition of citric acid and sodium azide to reduce background color development and to inhibit the activity of catalase, respectively.	Citric Acid	47-58	catalase	Homo sapiens	146-154
6635261-6	1983	NaHCO3 or citrate was found to give a synergistic effect on the binding of 67Ga to transferrin, as well as Fe-transferrin.	Citric Acid	10-17	transferrin	Homo sapiens	83-94
24263450-0	1983	Identification of citrate as the albumin-bound inhibitor of the ferroxidase activity of ceruloplasmin.	Citric Acid	18-25	ceruloplasmin	Homo sapiens	88-101
6635261-6	1983	NaHCO3 or citrate was found to give a synergistic effect on the binding of 67Ga to transferrin, as well as Fe-transferrin.	Citric Acid	10-17	transferrin	Homo sapiens	110-121
6635261-8	1983	3 The release of 59Fe from 59Fe-transferrin was enhanced with adenosine triphosphate (ATP), citrate, or ascorbic acid, while any of these reagents did not affect the release of 67Ga from 67Ga-transferrin.	Citric Acid	92-99	transferrin	Homo sapiens	32-43
6401714-5	1983	14CO2 production from glucose or citrate was similar in control and experimental conditions in the two regions.	Citric Acid	33-40	complement C2	Homo sapiens	2-5
6824684-7	1983	In citrate-containing plasma, the fibrinogen clotting was significantly delayed by an equimolar concentration of fragment D. In barium sulfate-adsorbed oxalated plasma, containing 2.5 mM Ca2+, the same amount of fragment D hardly affected fibrin polymerization.	Citric Acid	3-10	fibrinogen beta chain	Homo sapiens	34-44
6847645-0	1983	Alteration of hepatic glucocorticoid receptor stability and nuclear binding in vitro by citrate.	Citric Acid	88-95	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	22-45
7139922-4	1982	CK-BB" is quite stable, and probably results from binding of cations to CK-BB, because the transformation is prevented by EDTA and citrate.	Citric Acid	131-138	creatine kinase B	Rattus norvegicus	0-5
6402584-1	1983	Organic acids such as citric acid enhance the vaginal absorption of luteinizing hormone-releasing hormone, the potent analogue (leuprolide), and insulin.	Citric Acid	22-33	gonadotropin releasing hormone 1	Rattus norvegicus	68-105
7139922-4	1982	CK-BB" is quite stable, and probably results from binding of cations to CK-BB, because the transformation is prevented by EDTA and citrate.	Citric Acid	131-138	creatine kinase B	Rattus norvegicus	72-77
6294903-3	1982	Before adding the fibrinogen, the citric acid was always neutralized with sodium hydrogen carbonate.	Citric Acid	34-45	fibrinogen beta chain	Homo sapiens	18-28
18546124-5	1982	It proved to be lower than 55 h for both enzymes if adsorbed on zeolite treated with 2N HCl, and 15-fold and 30-fold higher for glucose oxidase and catalase adsorbed, respectively, on zeolite treated with the 0.1M citric-phosphate buffer and 0.01M citric acid.	Citric Acid	248-259	catalase	Homo sapiens	148-156
6982956-5	1982	If the dilution of the blood sample with citrate solution is taken into account in calculating the activity in citrated plasma, it is apparent that higher values are found in plasma than in serum (median 13%): Hence, the in vivo-alpha 1-antitrypsin activity can most probably be better determined using a plasma sample.	Citric Acid	41-48	serpin family A member 1	Homo sapiens	229-248
7158392-5	1982	Removal of citrate with a combination of citrate lyase, malate dehydrogenase and lactate dehydrogenase did, however, completely abolish its ability to bind zinc.	Citric Acid	11-18	malic enzyme 1	Homo sapiens	56-76
6288209-0	1982	Effect of citrate on the reactions of cytochrome c with reductants and cyanide.	Citric Acid	10-17	cytochrome c, somatic	Homo sapiens	38-50
6955501-1	1982	The purpose of this study was to examine the effect of time, light and air exposure on the pH stability and demineralization ability of a standardized pH 1 citric acid solution.	Citric Acid	156-167	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	151-155
6288209-4	1982	Substitution of citrate for morpholinopropane sulphonate in isoionic buffer media increases the apparent dissociation constant for cyanide suggesting citrate stabilizes the cytochrome c heme crevice.	Citric Acid	16-23	cytochrome c, somatic	Homo sapiens	173-185
6288209-4	1982	Substitution of citrate for morpholinopropane sulphonate in isoionic buffer media increases the apparent dissociation constant for cyanide suggesting citrate stabilizes the cytochrome c heme crevice.	Citric Acid	150-157	cytochrome c, somatic	Homo sapiens	173-185
6955501-2	1982	A 0.5 liter pH 1 citric acid solution was prepared and examined over a 5 month period.	Citric Acid	17-28	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	12-16
6955501-3	1982	The results indicated that pH 1 citric acid and solutions prepared under the described conditions remained stable during the examination period with regards to all tested variables.	Citric Acid	32-43	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	27-31
7069860-12	1982	Also testosterone possibly regulated prostate citrate production by its effect on the level of mitochondrial AAT activity.	Citric Acid	46-53	serpin family A member 1	Rattus norvegicus	109-112
6751301-7	1982	Regeneration of used insulin-dialyzers was accomplished by treatment with 0.02 M citrate buffer pH 3.2, which restored their ability to clear 90% and 40% of high affinity and total insulin antibodies, respectively.	Citric Acid	81-88	insulin	Homo sapiens	21-28
6751301-7	1982	Regeneration of used insulin-dialyzers was accomplished by treatment with 0.02 M citrate buffer pH 3.2, which restored their ability to clear 90% and 40% of high affinity and total insulin antibodies, respectively.	Citric Acid	81-88	insulin	Homo sapiens	181-188
6280764-1	1982	Citrate and other polyanion binding to ferricytochrome c partially blocks reduction by ascorbate, but at constant ionic strength the citrate-cytochrome c complex remains reducible; reduction by TMPD is unaffected.	Citric Acid	0-7	cytochrome c, somatic	Homo sapiens	44-56
6280764-2	1982	At a constant high ionic strength citrate inhibits the cytochrome c oxidase reaction competitively with respect to cytochrome c, indicating that ferrocytochrome c also binds citrate, and that the citrate-ferrocytochrome c complex is rejected by the binding site at high ionic strength.	Citric Acid	34-41	cytochrome c, somatic	Homo sapiens	55-67
6280764-2	1982	At a constant high ionic strength citrate inhibits the cytochrome c oxidase reaction competitively with respect to cytochrome c, indicating that ferrocytochrome c also binds citrate, and that the citrate-ferrocytochrome c complex is rejected by the binding site at high ionic strength.	Citric Acid	34-41	cytochrome c, somatic	Homo sapiens	115-127
6280764-2	1982	At a constant high ionic strength citrate inhibits the cytochrome c oxidase reaction competitively with respect to cytochrome c, indicating that ferrocytochrome c also binds citrate, and that the citrate-ferrocytochrome c complex is rejected by the binding site at high ionic strength.	Citric Acid	174-181	cytochrome c, somatic	Homo sapiens	55-67
6280764-2	1982	At a constant high ionic strength citrate inhibits the cytochrome c oxidase reaction competitively with respect to cytochrome c, indicating that ferrocytochrome c also binds citrate, and that the citrate-ferrocytochrome c complex is rejected by the binding site at high ionic strength.	Citric Acid	174-181	cytochrome c, somatic	Homo sapiens	115-127
6280764-4	1982	The turnover at low cytochrome c concentrations is diminished by citrate but not the Km (apparent non-competitive inhibition) or the rate of cytochrome a reduction by bound cytochrome c.	Citric Acid	65-72	cytochrome c, somatic	Homo sapiens	20-32
7102130-4	1982	The conspicuous incidence of calculi when there is a concurrence of hypocitraturia and alkaline urine (RTA, in animal experiments: acetazolamide) clearly suggests the lithoprotective significance of citric acid.	Citric Acid	199-210	RT1 class I, locus A	Rattus norvegicus	103-106
7184470-6	1982	The ODC reaction was terminated by addition of citric acid to the buffer and the amount of 14CO2 released was determined by scintillation counting of a center well filled with trapping agent.	Citric Acid	47-58	ornithine decarboxylase, structural 1	Mus musculus	4-7
7056739-10	1982	Iron on uteroferrin is relatively stable to pH and is not readily lost to transferrin at around neutral pH unless low molecular iron chelators such as citrate, pyrophosphate, ATP, or ascorbate are present.	Citric Acid	151-158	acid phosphatase 5, tartrate resistant	Sus scrofa	8-19
7082318-7	1982	The C-6 of citrate (which is removed in the isocitrate dehydrogenase reaction) and the remainder of the molecule showed differential labelling kinetics, the specific radioactivity of C-6 declining more rapidly.	Citric Acid	11-18	complement C6	Rattus norvegicus	4-7
7082318-7	1982	The C-6 of citrate (which is removed in the isocitrate dehydrogenase reaction) and the remainder of the molecule showed differential labelling kinetics, the specific radioactivity of C-6 declining more rapidly.	Citric Acid	11-18	complement C6	Rattus norvegicus	183-186
6897227-4	1982	When plasma from rabbits injection 67Ga-citrate was dialyzed at pH 6.5-7.5, dissociation of Ga from transferrin showed an inverse pH-dependence.	Citric Acid	40-47	serotransferrin	Oryctolagus cuniculus	100-111
7057338-2	1982	Baseline serum PTH concentrations and the PTH rise in response to citrate-induced hypocalcemia were studied.	Citric Acid	66-73	parathyroid hormone	Homo sapiens	42-45
7057338-4	1982	The acute response of PTH to citrate-induced hypocalcemia appears within ten minutes following the initiation of exchange transfusion and was shortlived in spite of further decline of serum ionized calcium.	Citric Acid	29-36	parathyroid hormone	Homo sapiens	22-25
6185934-3	1982	One possibility is that aspartate aminotransferase (AAT) could supply an extra Krebs cycle source of oxaloacetate for citrate formation.	Citric Acid	118-125	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	24-50
6185934-3	1982	One possibility is that aspartate aminotransferase (AAT) could supply an extra Krebs cycle source of oxaloacetate for citrate formation.	Citric Acid	118-125	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	52-55
6185934-4	1982	Since testosterone regulates citrate production and secretion and strong transaminase activity exists in prostate, a relationship between AAT and citrate production could exist if testosterone also regulates AAT activity.	Citric Acid	146-153	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	138-141
6185934-4	1982	Since testosterone regulates citrate production and secretion and strong transaminase activity exists in prostate, a relationship between AAT and citrate production could exist if testosterone also regulates AAT activity.	Citric Acid	146-153	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	208-211
7034387-1	1981	In adult coeliac sprue patients, intraduodenal instillation of a hypertonic glucose-citric acid solution may release gastrointestinal hormones of the proximal (secretin, gastric inhibitory polypeptide, motilin) and distal (enteroglucagon, neurotensin) small intestine and, indirectly, of the pancreas (glucagon, insulin, pancreatic polypeptide).	Citric Acid	84-95	motilin	Homo sapiens	202-209
7034387-1	1981	In adult coeliac sprue patients, intraduodenal instillation of a hypertonic glucose-citric acid solution may release gastrointestinal hormones of the proximal (secretin, gastric inhibitory polypeptide, motilin) and distal (enteroglucagon, neurotensin) small intestine and, indirectly, of the pancreas (glucagon, insulin, pancreatic polypeptide).	Citric Acid	84-95	neurotensin	Homo sapiens	239-250
7034387-1	1981	In adult coeliac sprue patients, intraduodenal instillation of a hypertonic glucose-citric acid solution may release gastrointestinal hormones of the proximal (secretin, gastric inhibitory polypeptide, motilin) and distal (enteroglucagon, neurotensin) small intestine and, indirectly, of the pancreas (glucagon, insulin, pancreatic polypeptide).	Citric Acid	84-95	insulin	Homo sapiens	312-319
6978209-1	1981	When citrate plasma and serum of the same individual were tested simultaneously in the C1q-binding assay (C1qBA), binding levels in plasma were found to be 90-400% higher than in serum.	Citric Acid	5-12	complement C1q A chain	Homo sapiens	87-90
7304905-9	1981	In the following phase the force of contraction and the contractility normalised when heparin was employed, whilst when citrate was used there was a reduction of the force of contraction and of the contractility corresponding with the different dose of citrate of ACD-B and CPD.	Citric Acid	120-127	carboxypeptidase D	Canis lupus familiaris	264-277
7304905-9	1981	In the following phase the force of contraction and the contractility normalised when heparin was employed, whilst when citrate was used there was a reduction of the force of contraction and of the contractility corresponding with the different dose of citrate of ACD-B and CPD.	Citric Acid	253-260	carboxypeptidase D	Canis lupus familiaris	264-277
7266074-6	1981	While pyruvate kinase and those mitochondrial enzymes lying between citrate formation and isocitrate oxidation (citrate synthase, NADP+-and NAD+-isocitrate dehydrogenases) decline to some degree, mitochondrial succinate dehydrogenase and NAD+-malate dehydrogenase activities increase over the same period.	Citric Acid	68-75	citrate synthase	Rattus norvegicus	112-128
6454665-0	1981	The influence of citrate ions on the radiochemical purity of 99Tcm-human serum albumin.	Citric Acid	17-24	albumin	Homo sapiens	73-86
6458117-0	1981	Human fibrinogen binds EDTA and citrate.	Citric Acid	32-39	fibrinogen beta chain	Homo sapiens	6-16
6789496-4	1981	Addition of citrate restored the extent of ADP-induced secretion and of epinephrine-induced aggregation and secretion in heparin-PRP to that observed in citrate-PRP, and increased the extent of ADP-induced secretion in hirudin-PRP.	Citric Acid	12-19	prion protein	Homo sapiens	129-132
6789496-4	1981	Addition of citrate restored the extent of ADP-induced secretion and of epinephrine-induced aggregation and secretion in heparin-PRP to that observed in citrate-PRP, and increased the extent of ADP-induced secretion in hirudin-PRP.	Citric Acid	12-19	prion protein	Homo sapiens	161-164
6789496-4	1981	Addition of citrate restored the extent of ADP-induced secretion and of epinephrine-induced aggregation and secretion in heparin-PRP to that observed in citrate-PRP, and increased the extent of ADP-induced secretion in hirudin-PRP.	Citric Acid	12-19	prion protein	Homo sapiens	161-164
6789496-4	1981	Addition of citrate restored the extent of ADP-induced secretion and of epinephrine-induced aggregation and secretion in heparin-PRP to that observed in citrate-PRP, and increased the extent of ADP-induced secretion in hirudin-PRP.	Citric Acid	153-160	prion protein	Homo sapiens	161-164
6789496-4	1981	Addition of citrate restored the extent of ADP-induced secretion and of epinephrine-induced aggregation and secretion in heparin-PRP to that observed in citrate-PRP, and increased the extent of ADP-induced secretion in hirudin-PRP.	Citric Acid	153-160	prion protein	Homo sapiens	161-164
6453626-1	1981	Some properties of three interconvertible forms of rabbit muscle phosphofructokinase specifically eluted from DEAE-cellulose with 19 mM citrate in 0.1 M tris-phosphate buffer, pH 8,0 (I), with 0,3 M buffer (II) and 1.5 M NaCl (III) are compared.	Citric Acid	136-143	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	65-84
7221136-0	1981	[Changes in plasma pseudocholinesterase levels in citric acid-dextrose-preserved blood].	Citric Acid	50-61	butyrylcholinesterase	Homo sapiens	19-39
7236804-6	1981	Preincubation of the reconstituted system with citrate stimulated the rate of acetyl-CoA incorporation into I. Stimulation of biosynthesis of I occurred independently of the diurnal rhythm of the 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reductase) activity.	Citric Acid	47-54	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	238-255
6940133-4	1981	This molecule induces expression of terminal deoxynucleotidyl transferase (DNA nucleotidylexotransferase, EC 2.7.7.31) in transferase-negative murine thymocytes in vivo and in citro.	Citric Acid	176-181	deoxynucleotidyltransferase, terminal	Mus musculus	36-73
6940133-4	1981	This molecule induces expression of terminal deoxynucleotidyl transferase (DNA nucleotidylexotransferase, EC 2.7.7.31) in transferase-negative murine thymocytes in vivo and in citro.	Citric Acid	176-181	deoxynucleotidyltransferase, terminal	Mus musculus	75-104
16661476-4	1980	Citrate synthetase activity in purified glyoxysomes could be coupled readily to glutamate: oxaloacetate aminotransferase activity as a source of oxaloacetate, but coupling to malate dehydrogenase and malate resulted in low rates of citrate formation.	Citric Acid	232-239	malate dehydrogenase, cytoplasmic-like	Ricinus communis	175-195
6452177-1	1980	The sedimentation behaviour of the subform of rabbit muscle phosphofructokinase specifically eluted from DEAE cellulose by citrate was studied in different media by velocity experiments.	Citric Acid	123-130	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	60-79
6996699-3	1980	The kinetics of citrate as an activator of the hexokinase reaction are consistent with its reaction with AlATP present as a contaminant in commercial ATP to form Al citrate.	Citric Acid	16-23	hexokinase	Saccharomyces cerevisiae S288C	47-57
221136-16	1979	Administration of insulin causes serum citrate concentrations to decrease.	Citric Acid	39-46	insulin	Homo sapiens	18-25
7362856-2	1980	These mitochondria have a large capacity to flux pyruvate through the pyruvate carboxylase reaction causing an accumulation of malate, citrate and phosphoenolpyruvate.	Citric Acid	135-142	pyruvate carboxylase	Homo sapiens	70-90
116225-2	1979	The inhibition is reversed by citrate, 3-phosphoglycerate, malate, phosphate, and catecholamines, all of which have previously been described as activators of hexokinase at low pH.	Citric Acid	30-37	hexokinase	Saccharomyces cerevisiae S288C	159-169
503663-0	1979	Parathyroid hormone response in newborn infants during exchange transfusion with blood supplemented with citrate and phosphate: effect of iv calcium.	Citric Acid	105-112	parathyroid hormone	Homo sapiens	0-19
750695-6	1978	Following treatment of slides with 0.01 M citrate buffer, seven previously negative biopsies showed positive staining with neuraminidase-treated IgG.	Citric Acid	42-49	neuraminidase 1	Homo sapiens	123-136
432930-4	1979	Although the citrate anticoagulant was returned to the donor and there were some decreases in the concentrations of fibrinogen, platelets, and factors V and VIII, there were no changes of sufficient degree to suggest that development of a potential bleeding disorder.	Citric Acid	13-20	cytochrome c oxidase subunit 8A	Homo sapiens	157-161
435278-18	1979	The decreases in the concentrations of citrate and alpha-oxoglutarate indicate that isocitrate dehydrogenase and oxoglutarate dehydrogenase may be stimulated by factors other than their pathway substrates during the early stages of flight.	Citric Acid	39-46	oxoglutarate dehydrogenase	Homo sapiens	113-139
261674-7	1979	For example, phosphorylase or phosphofructokinase activities provide a quantitative indication of maximum flux through glycolysis-from-glycogen (i.e. anaerobic glycolysis); hexokinase activities provide a quantitative indication of maximum flux through glycolysis-from-glucose; 2-oxoglutarate dehydrogenase activities provide a quantitative indication of maximum flux through the citric acid cycle.	Citric Acid	380-391	hexokinase 1	Homo sapiens	173-183
925022-3	1977	Acetylation can be prevented by metabolizing the available acetyl-CoA to citrate with the addition of citrate synthase and oxalacetate to the translation system.	Citric Acid	73-80	citrate synthase	Homo sapiens	102-118
30489-0	1978	The effect of acid pH and citrate on the release and exchange of iron on rat transferrin.	Citric Acid	26-33	transferrin	Rattus norvegicus	77-88
30489-1	1978	The effect of acid pH and citrate on the exchange of iron between binding sites of rat transferrin has been studied.	Citric Acid	26-33	transferrin	Rattus norvegicus	87-98
30489-5	1978	At pH 7.4, randomization of iron on transferrin takes from 3 to 6 h in the presence of millimolar concentrations of citrate.	Citric Acid	116-123	transferrin	Rattus norvegicus	36-47
29888-4	1978	The bound fumarase was released from the membrane by the substrates, isocitrate, citrate or 2,3-diphosphoglycerate at low concentrations.	Citric Acid	72-79	fumarate hydratase	Rattus norvegicus	10-18
698186-6	1978	Citrate-mediated transfer of iron from ferritin to apotransferrin is first order with respect to ferritin, zero order with respect to transferrin, and has a complex dependence upon citrate concentration.	Citric Acid	0-7	transferrin	Homo sapiens	54-65
698186-6	1978	Citrate-mediated transfer of iron from ferritin to apotransferrin is first order with respect to ferritin, zero order with respect to transferrin, and has a complex dependence upon citrate concentration.	Citric Acid	181-188	transferrin	Homo sapiens	54-65
680639-11	1978	Plotting the calculated free mitochondrial oxaloacetate concentration against the citrate concentration measured in the mitochondrial pellet yielded a hyperbolic saturation curve, from which an apparent Km of citrate synthase for oxaloacetate in the intact cells of 2 micron can be derived, which is comparable to the value determined with purified rat liver citrate synthase.	Citric Acid	82-89	citrate synthase	Rattus norvegicus	209-225
354693-7	1978	But even after extensive modification, hexokinase PII still demonstrates negative cooperativity with MgATP and is still strongly activated by citrate when assayed at pH 6.5.	Citric Acid	142-149	hexokinase	Saccharomyces cerevisiae S288C	39-49
16660424-3	1978	ATP and citrate at 5 mm concentrations inhibited pyruvate kinase 27 and 34%, respectively.	Citric Acid	8-15	pyruvate kinase	Glycine max	49-64
7276932-2	1981	The order of the stabilities (log KML) of their A1(III) chelates are SA (13.7) less than EDTA (15.3) less than CIT (18.0) less than EDDHA (24.5) approximately equal to HBED (24.8).	Citric Acid	111-114	BCL2 related protein A1	Homo sapiens	48-55
647446-14	1978	Related studies have shown that citrate removed calcium bound by PPG; N6-substituted adenines were bound by PPG while three polyphosphorylated dinucleosides, HS3, HS2, and HS1, were displaced from it.	Citric Acid	32-39	serglycin	Homo sapiens	65-68
647446-14	1978	Related studies have shown that citrate removed calcium bound by PPG; N6-substituted adenines were bound by PPG while three polyphosphorylated dinucleosides, HS3, HS2, and HS1, were displaced from it.	Citric Acid	32-39	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta	Homo sapiens	172-175
21074-1	1977	1,2,3-Benzene-tricarboxylate, a known inhibitor of the mitochondrial tricarboxylate carrier, was found to inhibit pyruvate carboxylation as well as the transport of citrate out of the matrix in rat liver mitochondria incubated with pyruvate.	Citric Acid	165-172	solute carrier family 25 member 1	Rattus norvegicus	55-91
19087-4	1977	GTP, 2,3-diphosphoglycerate, ATP, ADP and citrate produced the most rapid exchange of iron between the two types of transferrin, but many other compounds showed some degree of activity.	Citric Acid	42-49	transferrin	Homo sapiens	116-127
861073-4	1977	The influence of heparin, EDTA, and citrate on C1 esterase inhibitor activity of normal plasma was also investigated.	Citric Acid	36-43	serpin family G member 1	Homo sapiens	47-68
20995-1	1977	It was demonstrated that 0.2 M citric acid (pH 2.5) inactivates highly-purified malate dehydrogenase from tea leaves; the degree of inactivation depends on temperature and time of incubation.	Citric Acid	31-42	malic enzyme 1	Homo sapiens	80-100
598455-2	1977	The interaction of phosphate and citrate with chondroitin sulfate-A (CSA) in binding to collagen was investigated in different environmental conditions.	Citric Acid	33-40	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	46-67
837895-1	1977	In the liver of adult diabetics, the activity of two enzymes of the citrate-cleavage pathway was increased, the change being statistically significant for NADP-malate dehydrogenase (+ 46%, p less than 0.05) but not significant for ATP citrate-lyase (+ 55%, p greater than 0.10).	Citric Acid	68-75	ATP citrate lyase	Homo sapiens	231-248
142370-3	1977	Citrate (administered separately and together with hydroxythiamin) is assumed to influence indirectly the transketolase activity affecting the total regulation of carbohydrate metabolism.	Citric Acid	0-7	transketolase	Homo sapiens	106-119
12594-2	1976	Bovine platelets were transferred by Sepharose 2B gel filtration from citrate-PRP into citrate free buffer (buffer-GFP).	Citric Acid	70-77	PRP@	Bos taurus	78-81
16659756-10	1976	The addition of glucose, fructose 1,6-diphosphate, pyruvate, citrate, succinate, or malate to the in vivo assay medium significantly increased measurable NR activity of leaf tissue from plants pretreated to extended dark periods at elevated temperature.	Citric Acid	61-68	inducible nitrate reductase [NADH] 1	Glycine max	154-156
12594-8	1976	Citrate-PRP resembles buffer-GFP: response is sensitive to the selective removal of calcium and excess magnesium inhibition is present.	Citric Acid	0-7	PRP@	Bos taurus	8-11
8120-5	1976	At pH 6.8 Zn2+ had no effect on the 19F magnetic resonance spectrum, however, citrate and acetate ions significantly sharpened the signal from the trifluoroacetyl probe at the N-terminal end (glycine A-1) of the insulin A chain.	Citric Acid	78-85	insulin	Homo sapiens	212-219
1036813-0	1976	The prothrombin time test: effect of varying citrate concentration.	Citric Acid	45-52	coagulation factor II, thrombin	Homo sapiens	4-15
181659-6	1976	PTH increases the production by bone cells of lactate, citric and carbonic acids, lysosomal enzymes, collagenase, and hyaluronic acid, some or all of which are concerned in the mechanism of bone resorption.	Citric Acid	55-61	parathyroid hormone	Homo sapiens	0-3
1276140-2	1976	In mitochondria contaminated with lysosomes, the time course and magnitude of ATP-dependent Mg2+ accumulation are influenced by various cytoplasmic substances, besides substrates of the citric acid cycle.	Citric Acid	186-197	mucin 7, secreted	Homo sapiens	92-95
183513-7	1976	Kidney mitochondrial function, as determined by in vitro measurements of citrate-stimulated respiratory rates and specific activities of isocitrate dehydrogenase, succinate dehydrogenase, malate dehydrogenase, and cytochrome c oxidase, appears to be unaffected by environmental heat.	Citric Acid	73-80	malic enzyme 1	Homo sapiens	188-208
955852-0	1976	Effect of testosterone, dihydrotestosterone, estradiol, and prolactin on the weight and citric acid content of the lateral lobe of the rat prostate.	Citric Acid	88-99	prolactin	Rattus norvegicus	60-69
955852-1	1976	This study has been designed to investigate possible potentiation of testosterone and dihydrotestosterone by estradiol and prolactin in augmenting weight and citric acid content of the rat lateral prostate.	Citric Acid	158-169	prolactin	Rattus norvegicus	123-132
178355-11	1976	Phosphofructokinase protected by citrate plus MgATP can also be modified by the incorporation of 1 or more mol of pyridoxal phosphate, but the enzyme so produced is capable of interacting with citrate and shows none of the properties herein described for the enzyme modified in the absence of citrate.	Citric Acid	33-40	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	0-19
178355-11	1976	Phosphofructokinase protected by citrate plus MgATP can also be modified by the incorporation of 1 or more mol of pyridoxal phosphate, but the enzyme so produced is capable of interacting with citrate and shows none of the properties herein described for the enzyme modified in the absence of citrate.	Citric Acid	193-200	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	0-19
178355-11	1976	Phosphofructokinase protected by citrate plus MgATP can also be modified by the incorporation of 1 or more mol of pyridoxal phosphate, but the enzyme so produced is capable of interacting with citrate and shows none of the properties herein described for the enzyme modified in the absence of citrate.	Citric Acid	193-200	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	0-19
8154-3	1976	The chemically modified forms of hexokinase and the native enzyme are affected in the same way by activators (citrate, D-malate, 3-phosphoglycerate and Pi) when the activity was measured at pH 6.6.	Citric Acid	110-117	hexokinase	Saccharomyces cerevisiae S288C	33-43
139173-2	1976	Citrate and fructose-6-phosphate elute PFK at concentrations of 1.0 and 2.5 mM respectively, i.e. without increasing the ionic strength of the starting buffer (similar to 0.12).	Citric Acid	0-7	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	39-42
179741-5	1976	Citrate, the other additive in ACD blood, causes a fall in ionised plasma calcium levels resulting in a stimulation of PTH secretion and mobilisation of calcium and phosphorus.	Citric Acid	0-7	parathyroid hormone	Homo sapiens	119-122
57111-9	1976	Ample information on the distribution of NAG activity in the CNS was obtained by using fast garnet GBC coupler and 0.1 M citrate buffer.	Citric Acid	121-128	sodium voltage-gated channel alpha subunit 7	Rattus norvegicus	41-44
1250158-7	1976	However, since a previous study has suggested a correlation between increased microtubule content and increased secretory status in the chief cell, one may speculate that increased microtubule content resulting from citric acid administration may also be associated with increased parathyroid hormone secretion.	Citric Acid	216-227	parathyroid hormone	Homo sapiens	281-300
1250158-8	1976	By this formulation, citric acid-induced hypercalcemia would be secondary to increased parathyroid hormone secretion, but the transient hypercalcemia that occurs after nephrectomy would take place in the absence of an increase in parathyroid hormone secretion.	Citric Acid	21-32	parathyroid hormone	Homo sapiens	87-106
127795-5	1975	In the presence of MgATP and at pH 7.0, the dissociation constant for the enzyme-citrate complex is 20 muM.	Citric Acid	81-88	latexin	Homo sapiens	103-106
64398-1	1976	Description of a micromethod for determining heat fibrinogen where 0.06 to 0.08 ml of citrate plasma are only required.	Citric Acid	86-93	fibrinogen beta chain	Homo sapiens	50-60
992942-7	1976	The smaller fractions, G-I-G-VII, were found to be derived from G-VIII by the action of trypsin-like protease contained in the extract of sperm heads with 1% citric acid.	Citric Acid	158-169	cytochrome c oxidase subunit 8A	Homo sapiens	66-70
992942-7	1976	The smaller fractions, G-I-G-VII, were found to be derived from G-VIII by the action of trypsin-like protease contained in the extract of sperm heads with 1% citric acid.	Citric Acid	158-169	kallikrein related peptidase 11	Homo sapiens	88-109
127795-6	1975	At 50 muM citrate and excess magnesium ion, the concentration of ATP required to give half-maximal binding of citrate is approximately 3 muM .	Citric Acid	10-17	latexin	Homo sapiens	6-9
127795-6	1975	At 50 muM citrate and excess magnesium ion, the concentration of ATP required to give half-maximal binding of citrate is approximately 3 muM .	Citric Acid	10-17	latexin	Homo sapiens	137-140
127795-6	1975	At 50 muM citrate and excess magnesium ion, the concentration of ATP required to give half-maximal binding of citrate is approximately 3 muM .	Citric Acid	110-117	latexin	Homo sapiens	6-9
127795-6	1975	At 50 muM citrate and excess magnesium ion, the concentration of ATP required to give half-maximal binding of citrate is approximately 3 muM .	Citric Acid	110-117	latexin	Homo sapiens	137-140
127795-7	1975	Both P-enolpyruvate and 3-P-glycerate compete for the binding of citrate and the estimated Ki values are 480 and 52 muM, respectively.	Citric Acid	65-72	latexin	Homo sapiens	116-119
1168730-0	1975	Gallium-67 citrate uptake by cultured tumor cells, stimulated by serum transferrin.	Citric Acid	11-18	transferrin	Mus musculus	71-82
5407-5	1975	The high pHi of ACD blood was a results of the temperature at which the pHe and the pHi were measured (4degrees) and the presence of citrate anions in the medium, and could be explained by application of the Donnan-Gibbs equilibrium.	Citric Acid	133-140	glucose-6-phosphate isomerase	Homo sapiens	9-12
1003-2	1975	The activities of citrate synthase and NAD+-linked and NADP+-linked isocitrate dehydrogenases were measured in nervous tissue from different animals in an attempt to provide more information about the citric acid cycle in this tissue.	Citric Acid	201-212	citrate synthase	Homo sapiens	18-34
1113-1	1975	The modified procedure for rabbit skeletal muscle phosphofructokinase (PFK) purification is worked out utioizing the method of specific elution from DEAE-cellulose in 0.1 M tris-EDTA-phosphate pH 8.0 with 10 mM citrate.	Citric Acid	211-218	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	71-74
236846-2	1975	(b) Of the enzymes of the citrate cleavage pathway, ATP citrate lyase and malate dehydrogenase (decarboxylating) (NADP+) were virtually absent in the cells studied.	Citric Acid	26-33	ATP citrate lyase	Homo sapiens	52-69
164301-9	1975	Serum citrate as measured by both procedures during a glucose tolerance test was decreased from initial values under the influence of administered glucose (and endogenous insulin).	Citric Acid	6-13	insulin	Homo sapiens	171-178
175244-5	1975	During oxidation of succinate (citrate, malate or alpha-ketoglutarate) by the cells with ER close to zero, reduction of cytochrome c takes place only some time after the beginning of oxygen uptake.	Citric Acid	31-38	cytochrome c, somatic	Homo sapiens	120-132
1183727-6	1975	Of the citrate cleavage pathway enzymes, ATP citrate-lyase, although having a lower activity than malate dehydrogenase and malate dehydrogenase (decarboxylating) (NADP), was readily measurable, which contrasts with previous data by others.	Citric Acid	7-14	ATP citrate lyase	Homo sapiens	41-58
1183727-6	1975	Of the citrate cleavage pathway enzymes, ATP citrate-lyase, although having a lower activity than malate dehydrogenase and malate dehydrogenase (decarboxylating) (NADP), was readily measurable, which contrasts with previous data by others.	Citric Acid	7-14	malic enzyme 1	Homo sapiens	98-118
1183727-6	1975	Of the citrate cleavage pathway enzymes, ATP citrate-lyase, although having a lower activity than malate dehydrogenase and malate dehydrogenase (decarboxylating) (NADP), was readily measurable, which contrasts with previous data by others.	Citric Acid	7-14	malic enzyme 1	Homo sapiens	123-143
1293-1	1975	The thresholds of the pH for citric acid (pH=4.9) were found to exceed by 1.4 pH the thresholds for HC1 (3.5) at 1.2 mmol/1 bicarbonate in the solution.	Citric Acid	29-40	CYCS pseudogene 39	Homo sapiens	100-103
1293-2	1975	The reaction to citric acid was higher than to HC1 at equal pH.	Citric Acid	16-27	CYCS pseudogene 39	Homo sapiens	47-50
123467-1	1975	Equilibrium binding studies of the interaction of rabbit muscle phosphofructokinase with fructose 6-phosphate and fructose 1,6-bisphosphate have been carried out at 5 degrees in the presence of 1-10 mM potassium phosphate (pH 7.0 and 8.0), 5 mM citrate (pH 7.0), or 0.22 mm adenylyl imidodiphosphate (pH 7.0 and 8.0).	Citric Acid	245-252	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	64-83
4748832-1	1973	Equilibrium-dialysis experiments showed that Tris or citrate in the solution prevented copper from occupying completely the specific metal-binding sites on human transferrin.	Citric Acid	53-60	transferrin	Homo sapiens	162-173
808936-3	1975	Iron-donating activity of the supernatant was subsequently compared to that of a fresh preparation equal in iron and transferrin concentration; it was found significantly reduced, but gradually improving in presence of 10(-3)M citrate.	Citric Acid	227-234	transferrin	Rattus norvegicus	117-128
4745218-0	1973	Calcitonin effects on plasma and urinary citrate levels in rats.	Citric Acid	41-48	calcitonin-related polypeptide alpha	Rattus norvegicus	0-10
1136707-5	1975	(3) G-6-PDH, G-PDH and oxidoreductases acting within the citric acid cycle are demonstrable only in single cells of the interfascicular oligodendroglia of adult rabbit brains, while almost all cells exhibit appreciable activity of HBDH and NADH-2 tetrazolium dehydrogenase.	Citric Acid	57-68	NADH dehydrogenase subunit 2	Oryctolagus cuniculus	240-246
1111077-0	1975	GLC determination of PPB levels of citrate by conversion to bromoform.	Citric Acid	35-42	histatin 1	Homo sapiens	21-24
175415-8	1975	Citric acid cycle flux was coordinated by activational interactions at citrate synthase, isocitrate dehydrogenase, and alpha-ketoglutarate dehydrogenase, but a transient imbalance between the individual cycle steps leads to a sharp peak of lactate production shortly after the work transition.	Citric Acid	0-11	citrate synthase	Homo sapiens	71-87
4214890-7	1974	Significant exchange of iron from transferrin to lactoferrin was observed in vitro only at a pH below 7.0 or in the presence of a high concentration of citrate.	Citric Acid	152-159	transferrin	Homo sapiens	34-45
4214890-7	1974	Significant exchange of iron from transferrin to lactoferrin was observed in vitro only at a pH below 7.0 or in the presence of a high concentration of citrate.	Citric Acid	152-159	lactotransferrin	Rattus norvegicus	49-60
5076790-0	1972	The determination of part-per-billion levels of citric and nitrilotriacetic acids in tap water and sewage effluents.	Citric Acid	48-54	nuclear RNA export factor 1	Homo sapiens	85-88
4725035-7	1973	The observed rates of H(14)CO(3) (-) fixation and citrate formation correlated with the measured activities of pyruvate carboxylase and citrate synthase in the mitochondria.	Citric Acid	50-57	pyruvate carboxylase	Rattus norvegicus	111-131
4725035-7	1973	The observed rates of H(14)CO(3) (-) fixation and citrate formation correlated with the measured activities of pyruvate carboxylase and citrate synthase in the mitochondria.	Citric Acid	50-57	citrate synthase	Rattus norvegicus	136-152
4345356-17	1972	Citrate content was increased in the kidney cortex of diabetic and growth hormone-treated rats but was unchanged in cortisone-treated rats.	Citric Acid	0-7	gonadotropin releasing hormone receptor	Rattus norvegicus	67-81
5158897-11	1971	They also support the view that oxaloacetate for citrate synthesis is preferentially formed from pyruvate through pyruvate carboxylase rather than malate through malate dehydrogenase and that the mitochondrial metabolism of citrate in fat-cells is restricted.	Citric Acid	49-56	pyruvate carboxylase	Homo sapiens	114-134
5158898-5	1971	Mitochondria prepared from fat-cells exposed to insulin put out more citrate than non-insulin-treated controls under conditions where the oxaloacetate moiety of citrate was formed from pyruvate by pyruvate carboxylase and under conditions where it was formed from malate.	Citric Acid	69-76	insulin	Homo sapiens	48-55
5158898-5	1971	Mitochondria prepared from fat-cells exposed to insulin put out more citrate than non-insulin-treated controls under conditions where the oxaloacetate moiety of citrate was formed from pyruvate by pyruvate carboxylase and under conditions where it was formed from malate.	Citric Acid	161-168	insulin	Homo sapiens	48-55
5158898-5	1971	Mitochondria prepared from fat-cells exposed to insulin put out more citrate than non-insulin-treated controls under conditions where the oxaloacetate moiety of citrate was formed from pyruvate by pyruvate carboxylase and under conditions where it was formed from malate.	Citric Acid	161-168	insulin	Homo sapiens	86-93
5158898-5	1971	Mitochondria prepared from fat-cells exposed to insulin put out more citrate than non-insulin-treated controls under conditions where the oxaloacetate moiety of citrate was formed from pyruvate by pyruvate carboxylase and under conditions where it was formed from malate.	Citric Acid	161-168	pyruvate carboxylase	Homo sapiens	197-217
5165527-0	1971	Stereochemistry of the interconversions of citrate and acetate catalyzed by citrate synthase, adenosine triphosphate citrate lyase, and citrate lyase.	Citric Acid	43-50	citrate synthase	Homo sapiens	76-92
5283959-2	1971	Rat prothrombin has now been purified by disc electrophoresis after BaSO(4) adsorption and citrate elution.	Citric Acid	91-98	coagulation factor II	Rattus norvegicus	4-15
5527949-0	1970	Parathyroid hormone effects on soft-tissue citrate levels.	Citric Acid	43-50	parathyroid hormone	Homo sapiens	0-19
5461512-0	1970	The effects of Na+ and K+ on the citrate activation of prothrombin and on the esterase activities of thrombokinase.	Citric Acid	33-40	coagulation factor II, thrombin	Homo sapiens	55-66
5820638-12	1969	The behaviour of glyoxylate in producing multiple inhibitions of the citric acid cycle, either by direct interaction with oxoglutarate dehydrogenase, or by means of its condensation compounds which inhibit aconitate hydratase and isocitrate dehydrogenase, is discussed.	Citric Acid	69-80	oxoglutarate dehydrogenase	Homo sapiens	122-148
17387923-4	1968	The plutonium complex is considered to be less stable than the iron-transferrin complex, but plutonium can only be released from the transferrin complex by citrate or stronger chelating agents.	Citric Acid	156-163	transferrin	Homo sapiens	133-144
5812939-9	1969	The final product of pyruvate carboxylase action in the mitochondrial and particle-free supernatant fractions of lactating rat mammary gland was shown to be citrate.	Citric Acid	157-164	pyruvate carboxylase	Rattus norvegicus	21-41
4387231-0	1969	Oxygen uptake and 14CO2 production from citrate and isocitrate by control and parathyroid hormone-treated bone maintained in tissue culture.	Citric Acid	40-47	complement C2	Homo sapiens	20-23
14564711-6	1967	Consequently, the pyruvate carboxylase in adipose tissue both generates mitochondrial oxaloacetate for the citrate cleavage pathway and supplies soluble NADPH for the conversion of acetyl-CoA to fatty acid.	Citric Acid	107-114	pyruvate carboxylase	Rattus norvegicus	18-38
4386407-4	1968	Incorporation of either of these labelled carbon atoms into fatty acids would require a functioning citrate-cleavage pathway which consists of the enzymes ATP-citrate lyase, NAD-malate dehydrogenase and NADP-malate dehydrogenase.	Citric Acid	100-107	ATP citrate lyase	Rattus norvegicus	155-172
4386407-9	1968	Measurement of the citrate-cleavage pathway by incorporation studies with [3-(14)C]aspartate and [U-(14)C]glucose and by determining the activities of ATP-citrate lyase and NADP-malate dehydrogenase have shown that this sequence of reactions is present in the liver of the bovine foetus but not in the adult.	Citric Acid	19-26	ATP citrate lyase	Bos taurus	151-168
5650365-12	1968	The effects of starvation and diabetes on the citrate and acetyl-CoA contents are discussed in relation to control of gluconeogenesis, fatty acid synthesis and the activity of citrate synthase.	Citric Acid	46-53	citrate synthase	Rattus norvegicus	176-192
6026240-0	1967	Esterase and clotting activities derived from citrate activation of human prothrombin.	Citric Acid	46-53	coagulation factor II, thrombin	Homo sapiens	74-85
4962163-18	1967	Citrate formation was enhanced, owing to de-inhibition of citrate synthase.	Citric Acid	0-7	citrate synthase	Homo sapiens	58-74
6033777-11	1967	Under the conditions used, citrate had an inhibitory effect on the 6-bromo-2-naphthyl beta-galactosidase activity at pH3-4, but did not influence the 6-bromo-2-naphthyl beta-galactosidase activity at pH5-6 or the hydrolysis of the other substrates at any pH.	Citric Acid	27-34	galactosidase, beta 1	Rattus norvegicus	86-104
4288254-0	1966	Chlordiazepoxide and diphenylhydantoin as antagonists to ACTH effect on serum calcium and citrate levels.	Citric Acid	90-97	proopiomelanocortin	Homo sapiens	57-61
4287908-0	1966	The inhibition by citrate of inorganic pyrophosphate-glucose phosphotransferase and glucose 6-phosphatase.	Citric Acid	18-25	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	84-105
4229016-0	1966	[Changes in the enzymatic capacity of hexokinase, phosphofructokinase and pyruvate kinase in red blood cells in preservation with ACD and citrate-free stabilizers].	Citric Acid	138-145	hexokinase 1	Homo sapiens	38-48
14333562-9	1965	The radioactivity in citrate was predominantly in C-6, suggesting some carboxylation of alpha-oxoglutarate in addition to carboxylation of C(3) compounds.	Citric Acid	21-28	complement component C6	Capra hircus	50-53
5880050-0	1965	The level of citrate in CSF after acute intracranial injury.	Citric Acid	13-20	colony stimulating factor 2	Homo sapiens	24-27
14333562-11	1965	[1-(14)C]Glutamate was infused in a similar experiment, and milk citrate radioactivity was predominantly in C-1+C-5.	Citric Acid	65-72	complement C5	Capra hircus	112-115
13782126-0	1960	[Use of a polytropic 2-layer culture medium (CIG) for the simultaneous study of citrate utilization, indole production and gelatin liquefaction].	Citric Acid	80-87	fibronectin 1	Homo sapiens	45-48
14431648-0	1959	Effect of insulin acid tolbutamide on blood citric acid in rabbits.	Citric Acid	44-55	insulin	Oryctolagus cuniculus	10-17
13742556-0	1960	Two-layer polytrophic culture medium (CIG) for simultaneous investigation of citrate utilization, indole formation and gelatine liquefaction.	Citric Acid	77-84	fibronectin 1	Homo sapiens	38-41
13053221-0	1953	Response of serum citric acid levels in schizophrenics to the intramuscular administration of insulin.	Citric Acid	18-29	insulin	Homo sapiens	94-101
13465193-0	1957	[Effect of adrenocorticotropic hormone on citric acid level in the blood in experimental vitamin C deficiency].	Citric Acid	42-53	proopiomelanocortin	Homo sapiens	11-38
13028250-0	1952	[Concerning the presence of citrate in commercial crystallized bovine serum albumin].	Citric Acid	28-35	albumin	Homo sapiens	76-83
33676027-12	2021	Specifically, blockade of ACO2 caused reduction in TCA cycle intermediates and suppression of mitochondrial oxidative phosphorylation, resulting in increase of glycolysis and elevated citrate flux for fatty acid and lipid synthesis.	Citric Acid	184-191	aconitase 2	Homo sapiens	26-30
13218177-0	1954	Role of citrate in stimulation of oxygen consumption by insulin in frog muscle.	Citric Acid	8-15	insulin	Homo sapiens	56-63
33744326-0	2021	Citrate activates autophagic death of prostate cancer cells via downregulation CaMKII/AKT/mTOR pathway.	Citric Acid	0-7	calcium/calmodulin-dependent protein kinase II, delta	Mus musculus	79-85
33744326-0	2021	Citrate activates autophagic death of prostate cancer cells via downregulation CaMKII/AKT/mTOR pathway.	Citric Acid	0-7	thymoma viral proto-oncogene 1	Mus musculus	86-89
33744326-0	2021	Citrate activates autophagic death of prostate cancer cells via downregulation CaMKII/AKT/mTOR pathway.	Citric Acid	0-7	mechanistic target of rapamycin kinase	Mus musculus	90-94
33744326-9	2021	Based on the Ca2+-chelating property of citrate, the further study suggested that citrate activates autophagic cell death in prostate cancer cells via downregulation CaMKII/AKT/mTOR pathway.	Citric Acid	40-47	calcium/calmodulin-dependent protein kinase II, delta	Mus musculus	166-172
33744326-9	2021	Based on the Ca2+-chelating property of citrate, the further study suggested that citrate activates autophagic cell death in prostate cancer cells via downregulation CaMKII/AKT/mTOR pathway.	Citric Acid	40-47	mechanistic target of rapamycin kinase	Mus musculus	177-181
33744326-9	2021	Based on the Ca2+-chelating property of citrate, the further study suggested that citrate activates autophagic cell death in prostate cancer cells via downregulation CaMKII/AKT/mTOR pathway.	Citric Acid	82-89	calcium/calmodulin-dependent protein kinase II, delta	Mus musculus	166-172
33744326-9	2021	Based on the Ca2+-chelating property of citrate, the further study suggested that citrate activates autophagic cell death in prostate cancer cells via downregulation CaMKII/AKT/mTOR pathway.	Citric Acid	82-89	thymoma viral proto-oncogene 1	Mus musculus	173-176
33744326-9	2021	Based on the Ca2+-chelating property of citrate, the further study suggested that citrate activates autophagic cell death in prostate cancer cells via downregulation CaMKII/AKT/mTOR pathway.	Citric Acid	82-89	mechanistic target of rapamycin kinase	Mus musculus	177-181
33744326-12	2021	That citrate activates autophagic cell death of prostate cancer via downregulation CaMKII/AKT/mTOR pathway and without remarkable toxicity in mice.	Citric Acid	5-12	calcium/calmodulin-dependent protein kinase II, delta	Mus musculus	83-89
33744326-12	2021	That citrate activates autophagic cell death of prostate cancer via downregulation CaMKII/AKT/mTOR pathway and without remarkable toxicity in mice.	Citric Acid	5-12	thymoma viral proto-oncogene 1	Mus musculus	90-93
33744326-12	2021	That citrate activates autophagic cell death of prostate cancer via downregulation CaMKII/AKT/mTOR pathway and without remarkable toxicity in mice.	Citric Acid	5-12	mechanistic target of rapamycin kinase	Mus musculus	94-98
33676027-13	2021	Increased citrate flux was able to induce upregulation of stearoyl-CoA desaturase (SCD1), which enhanced lipid desaturation in ACO2-deficent cells to favor colorectal cancer growth.	Citric Acid	10-17	stearoyl-CoA desaturase	Homo sapiens	58-81
33676027-13	2021	Increased citrate flux was able to induce upregulation of stearoyl-CoA desaturase (SCD1), which enhanced lipid desaturation in ACO2-deficent cells to favor colorectal cancer growth.	Citric Acid	10-17	stearoyl-CoA desaturase	Homo sapiens	83-87
33676027-13	2021	Increased citrate flux was able to induce upregulation of stearoyl-CoA desaturase (SCD1), which enhanced lipid desaturation in ACO2-deficent cells to favor colorectal cancer growth.	Citric Acid	10-17	aconitase 2	Homo sapiens	127-131
34057673-2	2021	Astrocytes synthesize glutamate de novo owing to the pyruvate entry to the citric/tricarboxylic acid cycle via pyruvate carboxylase, an astrocyte specific enzyme.	Citric Acid	75-81	pyruvate carboxylase	Homo sapiens	111-131
33888605-0	2021	Citric acid in drug formulations causes pain by potentiating acid-sensing ion channel 1.	Citric Acid	0-11	acid sensing ion channel subunit 1	Homo sapiens	61-87
34002645-6	2021	In brain tissue from rats that were exposed to citrate-capped AuNPs for 12-weeks, tumour necrosis factor-alpha and interleukin-6 levels were significantly increased compared to the untreated control.	Citric Acid	47-54	interleukin 6	Rattus norvegicus	115-128
33888605-8	2021	Finally, removal of calcium ions from the extracellular solution mimicked the potentiating effect of citrate and prevented citrate from further potentiating ASIC1.	Citric Acid	123-130	acid sensing ion channel subunit 1	Homo sapiens	157-162
33888605-12	2021	In addition, we demonstrated that citrate potentiates ASIC1 by removing the inhibitory action of calcium on the extracellular side of the receptor.	Citric Acid	34-41	acid sensing ion channel subunit 1	Homo sapiens	54-59
34018557-3	2021	Roots of sdhaf2 mutants showed high accumulation of succinate, depletion of citrate and malate and up-regulation of ROS-related and stress-inducible genes at pH 5.5.	Citric Acid	76-83	succinate dehydrogenase assembly factor	Arabidopsis thaliana	9-15
33859156-12	2021	One bone marker, N-terminal propeptide of type I procollagen (PINP), significantly decreased from 146.07+-130.12 mmol/L to 92.42+-79.01 mmol/L after citrate treatment (P=0.018).	Citric Acid	149-156	collagen type I alpha 2 chain	Homo sapiens	42-60
33982576-4	2021	Increased BCAA levels in diabetes are due to alterations in glycolysis, citric acid cycle, and fatty acid oxidation.	Citric Acid	72-83	AT-rich interaction domain 4B	Homo sapiens	10-14
5667255-2	1968	Four of the citric acid-cycle enzymes (aconitase, succinyl-CoA thiokinase, alpha-oxoglutarate dehydrogenase and succinate dehydrogenase) have closely similar low activities; two [isocitrate dehydrogenase (NAD) and citrate synthase] have intermediate activities; the remaining two (malate dehydrogenase and fumarase) have high activities.	Citric Acid	12-23	citrate synthase	Rattus norvegicus	214-230
5667255-2	1968	Four of the citric acid-cycle enzymes (aconitase, succinyl-CoA thiokinase, alpha-oxoglutarate dehydrogenase and succinate dehydrogenase) have closely similar low activities; two [isocitrate dehydrogenase (NAD) and citrate synthase] have intermediate activities; the remaining two (malate dehydrogenase and fumarase) have high activities.	Citric Acid	12-23	fumarate hydratase	Rattus norvegicus	306-314
33848143-5	2021	Mutations to fumarate hydratase (FH), an enzyme of the citric acid cycle, can lead to human diseases.	Citric Acid	55-66	fumarate hydratase	Homo sapiens	13-31
33848143-5	2021	Mutations to fumarate hydratase (FH), an enzyme of the citric acid cycle, can lead to human diseases.	Citric Acid	55-66	fumarate hydratase	Homo sapiens	33-35
33882171-3	2021	In this research, osteosarcoma biomarker (miRNA-195) was identified by citrate-capped GNP-colorimetric assay.	Citric Acid	71-78	microRNA 195	Homo sapiens	42-51
33923786-0	2021	Citric Acid Cycle Metabolites Predict Infarct Size in Pigs Submitted to Transient Coronary Artery Occlusion and Treated with Succinate Dehydrogenase Inhibitors or Remote Ischemic Perconditioning.	Citric Acid	0-11	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	125-148
33222147-8	2021	After IR, a substantial decrease in the citric acid level in CA1, an accumulation of pipecolic acid in both regions, and opposite changes in the amount of PE and LysoPE were observed.	Citric Acid	40-51	carbonic anhydrase 1	Homo sapiens	61-64
33880024-6	2021	Results: The experimental results showed that citrate-stabilized AuNRs have superior biocompatibility and undergo aspect-ratio-dependent osteogenic differentiation via expression of osteogenic marker genes, alkaline phosphatase (ALP) activity and formation of mineralized nodule.	Citric Acid	46-53	alkaline phosphatase, placental	Homo sapiens	207-227
33880024-6	2021	Results: The experimental results showed that citrate-stabilized AuNRs have superior biocompatibility and undergo aspect-ratio-dependent osteogenic differentiation via expression of osteogenic marker genes, alkaline phosphatase (ALP) activity and formation of mineralized nodule.	Citric Acid	46-53	alkaline phosphatase, placental	Homo sapiens	229-232
33880024-7	2021	Furthermore, Wnt/beta-catenin signaling pathway might provide a potential explanation for the citrate-stabilized AuNRs-mediated osteogenic differentiation.	Citric Acid	94-101	catenin beta 1	Homo sapiens	17-29
33880024-8	2021	Conclusion: These findings revealed that citrate-stabilized AuNRs with great biocompatibility could regulate the osteogenic differentiation of multiple cell types through Wnt/beta-catenin signaling pathway, which promote innovative AuNRs in the field of tissue engineering and other biomedical applications.	Citric Acid	41-48	catenin beta 1	Homo sapiens	175-187
33121804-5	2021	Under the acidic conditions caused by citric acid (pH = 4.5), DTC-LPEI-PUF could effectively adsorb Cd, and the adsorption rate reached equilibrium after 5 h. Theoretical calculations suggested that the absorption behavior followed pseudo -second order kinetics, and the saturated adsorption capacity of Cd by DTC-LPEI-PUF was 89.05 mg/g, obeying Langmuir isothermal adsorption models.	Citric Acid	38-49	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	71-74
33121804-5	2021	Under the acidic conditions caused by citric acid (pH = 4.5), DTC-LPEI-PUF could effectively adsorb Cd, and the adsorption rate reached equilibrium after 5 h. Theoretical calculations suggested that the absorption behavior followed pseudo -second order kinetics, and the saturated adsorption capacity of Cd by DTC-LPEI-PUF was 89.05 mg/g, obeying Langmuir isothermal adsorption models.	Citric Acid	38-49	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	319-322
33691969-2	2021	Malonyl CoA is an important intermediate in anthocyanin synthesis, and citrate, formed by citrate synthase (CS) catalysing oxaloacetate, is the precursor for the formation of malonyl-CoA.	Citric Acid	71-78	sperm mitochondria-associated cysteine-rich protein	Mus musculus	108-110
33610892-5	2021	In experimental groups CA10 and CA15, eggshells were sprayed with the aqueous solution of citric acid (10 and 15% concentration, respectively).	Citric Acid	90-101	carbonic anhydrase 10	Homo sapiens	23-27
33675134-1	2021	A series of Bi1-x Eux PO4 phosphors were successfully prepared via a facile citric acid-assisted hydrothermal method.	Citric Acid	76-87	transmembrane BAX inhibitor motif containing 6	Homo sapiens	12-15
33758075-3	2021	Here, we show for the first time that citrate is supplied to cancer by cancer-associated stroma (CAS) and also that citrate synthesis and release is one of the latter"s major metabolic tasks.	Citric Acid	38-45	BCAR1 scaffold protein, Cas family member	Homo sapiens	97-100
33758075-4	2021	Citrate release from CAS is controlled by cancer cells through cross-cellular communication.	Citric Acid	0-7	BCAR1 scaffold protein, Cas family member	Homo sapiens	21-24
33758075-5	2021	The availability of citrate from CAS regulated the cytokine profile, metabolism and features of cellular invasion.	Citric Acid	20-27	BCAR1 scaffold protein, Cas family member	Homo sapiens	33-36
33758075-6	2021	Moreover, citrate released by CAS is involved in inducing cancer progression especially enhancing invasiveness and organ colonisation.	Citric Acid	10-17	BCAR1 scaffold protein, Cas family member	Homo sapiens	30-33
33758075-8	2021	We conclude that citrate is supplied to tumour cells by CAS and citrate uptake plays a significant role in cancer metastatic progression.	Citric Acid	17-24	BCAR1 scaffold protein, Cas family member	Homo sapiens	56-59
33678882-3	2021	The 4 weeks of storage had a statistically significant (P < 0.05) effect on every tested parameter, while the addition of citric acid had a statistically significant (P < 0.05) effect on pH, conductivity, L* and b* values, protein solubility, emulsion activity index, emulsion capacity, emulsion stability, and an increase in foaming and texture parameters, but not on rheological parameters.	Citric Acid	122-133	phenylalanine hydroxylase	Homo sapiens	187-189
33325149-0	2021	Citrate utilization under anaerobic environment in Escherichia coli is under direct control of Fnr and indirect control of ArcA and Fnr via CitA-CitB system.	Citric Acid	0-7	arginine deiminase	Escherichia coli	123-127
33325149-7	2021	Deletions of arcA and fnr significantly reduced the growth of Escherichia coli in M9 medium with a citrate carbon source.	Citric Acid	99-106	arginine deiminase	Escherichia coli	13-17
33325149-8	2021	We conclude that both ArcA and Fnr can indirectly control the citrate utilization via CitA-CitB system, while, Fnr can also directly regulate the expression of citrate fermentation genes in E. coli under anaerobic conditions.	Citric Acid	62-69	arginine deiminase	Escherichia coli	22-26
33486087-10	2021	Furthermore, we find that albumin and transferrin have significantly different impacts on Fe(II)-mediated .OH than citrate, a common component of simulated lung fluids, a factor that should be considered carefully in the interpretation of results obtained from solutions containing citrate.	Citric Acid	115-122	transferrin	Homo sapiens	38-49
33486087-10	2021	Furthermore, we find that albumin and transferrin have significantly different impacts on Fe(II)-mediated .OH than citrate, a common component of simulated lung fluids, a factor that should be considered carefully in the interpretation of results obtained from solutions containing citrate.	Citric Acid	282-289	albumin	Homo sapiens	26-33
33486087-10	2021	Furthermore, we find that albumin and transferrin have significantly different impacts on Fe(II)-mediated .OH than citrate, a common component of simulated lung fluids, a factor that should be considered carefully in the interpretation of results obtained from solutions containing citrate.	Citric Acid	282-289	transferrin	Homo sapiens	38-49
33678882-4	2021	Citric acid addition and a storage period of 4 weeks resulted in a change of pH and an increase in protein solubility.	Citric Acid	0-11	phenylalanine hydroxylase	Homo sapiens	77-79
33597751-4	2021	Liver cells import citrate through the sodium-dependent citrate transporter NaCT (encoded by SLC13A5) and, as a consequence, this protein is a potential target for anti-obesity drugs.	Citric Acid	19-26	solute carrier family 13 member 5	Homo sapiens	76-80
33597751-4	2021	Liver cells import citrate through the sodium-dependent citrate transporter NaCT (encoded by SLC13A5) and, as a consequence, this protein is a potential target for anti-obesity drugs.	Citric Acid	19-26	solute carrier family 13 member 5	Homo sapiens	93-100
33597751-5	2021	Here, to understand the structural basis of its inhibition mechanism, we determined cryo-electron microscopy structures of human NaCT in complexes with citrate or a small-molecule inhibitor.	Citric Acid	152-159	solute carrier family 13 member 5	Homo sapiens	129-133
33597751-6	2021	These structures reveal how the inhibitor-which binds to the same site as citrate-arrests the transport cycle of NaCT.	Citric Acid	74-81	solute carrier family 13 member 5	Homo sapiens	113-117
33527430-8	2021	Moreover, citrate-free storage significantly reduced exposure of P-selectin and the apoptosis signal phosphatidylserine, thereby abolishing the activating effect of photochemical treatment on both parameters.	Citric Acid	10-17	selectin P	Homo sapiens	65-75
33625693-0	2021	Correction to: Citrate high volume on-line hemodiafiltration modulates serum Interleukin-6 and Klotho levels: the multicenter randomized controlled study "Hephaestus".	Citric Acid	15-22	interleukin 6	Homo sapiens	77-90
33625693-0	2021	Correction to: Citrate high volume on-line hemodiafiltration modulates serum Interleukin-6 and Klotho levels: the multicenter randomized controlled study "Hephaestus".	Citric Acid	15-22	klotho	Homo sapiens	95-101
33596250-6	2021	Our study suggests that use of an antigen retrieval buffer with higher pH value (such as Tris-EDTA pH9.0) than that of the stripping buffers (such as citrate buffer pH6.0) is helpful when using this advanced mIHC method to develop panels with multiple biomarkers.	Citric Acid	150-157	baculoviral IAP repeat-containing 3	Mus musculus	208-212
33594546-12	2021	Some of the selected metabolites, such as citric acid and methionine, were significantly associated with serum lipids and insulin resistance (P < 0.05).	Citric Acid	42-53	insulin	Oryctolagus cuniculus	122-129
32919374-1	2021	We investigated the inhibitory effect and binding mechanism of four selected compounds (ascorbic acid, l-cysteine, glutathione, and citric acid) on membrane-bound polyphenol oxidases (mPPO) using spectroscopic and molecular docking techniques.	Citric Acid	132-143	protoporphyrinogen oxidase	Mus musculus	184-188
33582830-5	2021	We identified significant interactions between age and creatinine clearance in predicting 24-h urine pH, calcium, and citrate.	Citric Acid	118-125	renin binding protein	Homo sapiens	47-50
33559851-0	2021	Citrate high volume on-line hemodiafiltration modulates serum Interleukin-6 and Klotho levels: the multicenter randomized controlled study "Hephaestus".	Citric Acid	0-7	interleukin 6	Homo sapiens	62-75
33559851-0	2021	Citrate high volume on-line hemodiafiltration modulates serum Interleukin-6 and Klotho levels: the multicenter randomized controlled study "Hephaestus".	Citric Acid	0-7	klotho	Homo sapiens	80-86
33559851-14	2021	CONCLUSIONS: Citrate buffer modulated IL-6, hsCRP and Klotho levels during high volume OL-HDF.	Citric Acid	13-20	interleukin 6	Homo sapiens	38-42
33559851-14	2021	CONCLUSIONS: Citrate buffer modulated IL-6, hsCRP and Klotho levels during high volume OL-HDF.	Citric Acid	13-20	klotho	Homo sapiens	54-60
33529218-5	2021	By investigating the level of citrate, the first metabolite of the TCA cycle, we demonstrate that the elevation of citrate depends on VACV-encoded viral growth factor (VGF), a viral homolog of cellular epidermal growth factor.	Citric Acid	30-37	VGF nerve growth factor inducible	Homo sapiens	168-171
33529218-5	2021	By investigating the level of citrate, the first metabolite of the TCA cycle, we demonstrate that the elevation of citrate depends on VACV-encoded viral growth factor (VGF), a viral homolog of cellular epidermal growth factor.	Citric Acid	115-122	VGF nerve growth factor inducible	Homo sapiens	168-171
33529218-5	2021	By investigating the level of citrate, the first metabolite of the TCA cycle, we demonstrate that the elevation of citrate depends on VACV-encoded viral growth factor (VGF), a viral homolog of cellular epidermal growth factor.	Citric Acid	115-122	epidermal growth factor	Homo sapiens	202-225
33529218-6	2021	Further, the upregulation of citrate is dependent on STAT3 signaling, which is activated non-canonically at the serine727 upon VACV infection.	Citric Acid	29-36	signal transducer and activator of transcription 3	Homo sapiens	53-58
33544126-1	2021	NaCT/SLC13A5 is a Na+-coupled transporter for citrate in hepatocytes, neurons, and testes.	Citric Acid	46-53	solute carrier family 13 member 5	Homo sapiens	0-4
33544126-1	2021	NaCT/SLC13A5 is a Na+-coupled transporter for citrate in hepatocytes, neurons, and testes.	Citric Acid	46-53	solute carrier family 13 member 5	Homo sapiens	5-12
33544126-6	2021	Mouse Slc13a5 is a low-capacity transporter, whereas human SLC13A5 is a high-capacity transporter, thus leading to quantitative differences in citrate entry into cells via the transporter.	Citric Acid	143-150	solute carrier family 13 (sodium-dependent citrate transporter), member 5	Mus musculus	6-13
33544126-6	2021	Mouse Slc13a5 is a low-capacity transporter, whereas human SLC13A5 is a high-capacity transporter, thus leading to quantitative differences in citrate entry into cells via the transporter.	Citric Acid	143-150	solute carrier family 13 member 5	Homo sapiens	59-66
33544126-8	2021	NaCT-mediated citrate entry in the liver impacts fatty acid and cholesterol synthesis, fatty acid oxidation, glycolysis, and gluconeogenesis; in neurons, this process is essential for the synthesis of the neurotransmitters glutamate, GABA, and acetylcholine.	Citric Acid	14-21	solute carrier family 13 member 5	Homo sapiens	0-4
33264632-9	2021	An impact of ART on mitochondria was observed for suppression of enzymes in the citric acid cycle (TCA), such as citrate synthase (CS), isocitrate dehydrogenase (IDH2), and alpha ketoglutarate dehydrogenase (OGDH) in a dose-dependent manner.	Citric Acid	80-91	citrate synthase	Mus musculus	113-129
33264632-9	2021	An impact of ART on mitochondria was observed for suppression of enzymes in the citric acid cycle (TCA), such as citrate synthase (CS), isocitrate dehydrogenase (IDH2), and alpha ketoglutarate dehydrogenase (OGDH) in a dose-dependent manner.	Citric Acid	80-91	citrate synthase	Mus musculus	131-133
33051847-8	2021	The effects of citrate and SRNOM on the transport and retention of QDs were pH dependent as reflected in the influence of the electrostatic and steric interactions between QDs and sand surfaces.	Citric Acid	15-22	phenylalanine hydroxylase	Homo sapiens	76-78
32926942-6	2021	Moreover, targeted metabolomics and 13C isotopic labeling experiments demonstrate that cells lacking the inner membrane fusion GTPase OPA1 undergo widespread metabolic remodeling altering the balance of citric acid cycle intermediates and ultimately favoring GSH synthesis.	Citric Acid	203-214	OPA1, mitochondrial dynamin like GTPase	Mus musculus	134-138
33167224-1	2021	An analytical methodology based on asymmetric flow field flow fractionation hyphenated to inductively coupled plasma mass spectrometry (AF4-ICP-MS) has been developed for monitoring citrate coated platinum nanoparticles (PtNPs) of different sizes (5, 30, and 50 nm) in water samples.	Citric Acid	182-189	AF4/FMR2 family member 1	Homo sapiens	136-139
33435350-0	2021	Rethinking the Citric Acid Cycle: Connecting Pyruvate Carboxylase and Citrate Synthase to the Flow of Energy and Material.	Citric Acid	15-26	citrate synthase	Homo sapiens	70-86
33513731-3	2021	Sulfuric acid, citric acid, and acetic acid were used to maintain the pH level, which varied from 5 to 2 for the precipitation process.	Citric Acid	15-26	phenylalanine hydroxylase	Homo sapiens	70-72
33513731-5	2021	The finding showed that the lignin isolated using citric acid maintained to pH 3 resulted in briquette with 72% fixed carbon content, excellent 99.7% DSI, and a calorific value equivalent to coal-based briquette.	Citric Acid	50-61	phenylalanine hydroxylase	Homo sapiens	76-78
33553891-2	2021	Here, we designed pH-responsive carboxylated cellulose microspheres (CCMs) by the citric/hydrochloric acid hydrolysis method to enhance oral bioavailability of insulin by a green route.	Citric Acid	82-88	insulin	Homo sapiens	160-167
33491666-7	2021	Citrate, the main mINDY substrate, increased catecholamine content in pheochromocytoma cells, while pharmacological inhibition of citrate uptake blunted the effect.	Citric Acid	0-7	solute carrier family 13 (sodium-dependent citrate transporter), member 5	Mus musculus	18-23
33499062-0	2021	The Mitochondrial Citrate Carrier SLC25A1/CIC and the Fundamental Role of Citrate in Cancer, Inflammation and Beyond.	Citric Acid	18-25	solute carrier family 25 member 1	Homo sapiens	34-41
33499062-0	2021	The Mitochondrial Citrate Carrier SLC25A1/CIC and the Fundamental Role of Citrate in Cancer, Inflammation and Beyond.	Citric Acid	18-25	capicua transcriptional repressor	Homo sapiens	42-45
33499062-1	2021	The mitochondrial citrate/isocitrate carrier, CIC, has been shown to play an important role in a growing list of human diseases.	Citric Acid	18-25	capicua transcriptional repressor	Homo sapiens	46-49
33167253-3	2021	By comparing the physico-chemical characteristics of hydroxyapatite material before and after reaction with beta-CD, all of these techniques have demonstrated the successful grafting process of beta-CD on the surface hydroxyl groups of hydroxyapatite, using citric acid (CA) as cross linker.	Citric Acid	258-269	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	194-201
33402732-8	2022	Metabolomic analysis revealed that modulation of GGCT expression induced a metabolic switch from the citric acid cycle to glycolysis under normoxia.	Citric Acid	101-112	gamma-glutamyl cyclotransferase	Mus musculus	49-53
33245891-7	2021	Additionally, TNFalpha production, strongly associating with the glycolysis enzyme Ldha/Ldhb, could be reduced as glycolysis was inhibited or be enhanced as citrate cycle was blocked.	Citric Acid	157-164	tumor necrosis factor	Rattus norvegicus	14-22
32415670-7	2021	KEY RESULTS: AITC- and citric acid- induced DBF were significantly reduced in Trpa1 KO rats compared to wildtype (90+- 2% and 65+- 11% reduction, respectively), whereas capsaicin response did not differ.	Citric Acid	23-34	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	78-83
32942044-13	2021	Mechanistically, L-PK altered mitochondrial pyruvate flux and its incorporation into citrate and this, in turn, increased liver triglycerides via upregulated de novo lipogenesis and increased PNPLA3 levels accompanied by mitochondrial dysfunction.	Citric Acid	85-92	pyruvate kinase liver and red blood cell	Mus musculus	17-21
33115805-3	2021	ACO2 promoted mitochondrial citrate synthesis to facilitate de novo lipogenesis, and genetic ablation of ACO2 reduced total lipid content and severely repressed in vivo prostate cancer progression.	Citric Acid	28-35	aconitase 2	Homo sapiens	0-4
33245891-7	2021	Additionally, TNFalpha production, strongly associating with the glycolysis enzyme Ldha/Ldhb, could be reduced as glycolysis was inhibited or be enhanced as citrate cycle was blocked.	Citric Acid	157-164	lactate dehydrogenase A	Rattus norvegicus	83-87
33245891-7	2021	Additionally, TNFalpha production, strongly associating with the glycolysis enzyme Ldha/Ldhb, could be reduced as glycolysis was inhibited or be enhanced as citrate cycle was blocked.	Citric Acid	157-164	lactate dehydrogenase B	Rattus norvegicus	88-92
33316744-11	2021	Biochemical analysis revealed that Sesn2 is associated with citrate cycle components to modulate pyruvate dehydrogenase and isocitrate dehydrogenase activities during I/R stress.	Citric Acid	60-67	sestrin 2	Mus musculus	35-40
32529549-5	2021	Citrate directly and irreversibly diminishes platelet function and even after recalcification, it may result in altered platelet aggregation in response to ADP, epinephrine or collagen, and interfere with thrombin generation from activated platelets.	Citric Acid	0-7	coagulation factor II, thrombin	Homo sapiens	205-213
32725557-4	2020	Significant interference on As(V) removal was caused by the presence of phosphate and natural organic acids (NOAs), such as citric acid.	Citric Acid	124-135	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	28-33
33359432-5	2022	Endogenously produced RO/NS from mitochondrial metabolic citric-acid-cycle coupled with electron-transport-chain or exogenous stimuli trigger cellular signaling events leading to homeostatic response or pathological damage.	Citric Acid	57-68	serine peptidase inhibitor Kazal type 5	Homo sapiens	22-27
33332393-0	2020	Citric acid promoted melanin synthesis in B16F10 mouse melanoma cells, but inhibited it in human epidermal melanocytes and HMV-II melanoma cells via the GSK3beta/beta-catenin signaling pathway.	Citric Acid	0-11	glycogen synthase kinase 3 alpha	Homo sapiens	153-161
33332393-0	2020	Citric acid promoted melanin synthesis in B16F10 mouse melanoma cells, but inhibited it in human epidermal melanocytes and HMV-II melanoma cells via the GSK3beta/beta-catenin signaling pathway.	Citric Acid	0-11	catenin beta 1	Homo sapiens	162-174
33332393-6	2020	Furthermore, the expression of factors important for melanin synthesis, such as microphthalmia-associated transcription factor (MITF), was also regulated by citric acid treatment-it was promoted in mouse cells and suppressed in human cells.	Citric Acid	157-168	melanogenesis associated transcription factor	Mus musculus	80-126
33332393-6	2020	Furthermore, the expression of factors important for melanin synthesis, such as microphthalmia-associated transcription factor (MITF), was also regulated by citric acid treatment-it was promoted in mouse cells and suppressed in human cells.	Citric Acid	157-168	melanogenesis associated transcription factor	Mus musculus	128-132
33332393-7	2020	Citric acid also impacted the upstream regulators of MITF, glycogen synthase kinase 3beta (GSK3beta), and beta-catenin.	Citric Acid	0-11	melanocyte inducing transcription factor	Homo sapiens	53-57
33332393-7	2020	Citric acid also impacted the upstream regulators of MITF, glycogen synthase kinase 3beta (GSK3beta), and beta-catenin.	Citric Acid	0-11	glycogen synthase kinase 3 beta	Homo sapiens	59-89
33332393-7	2020	Citric acid also impacted the upstream regulators of MITF, glycogen synthase kinase 3beta (GSK3beta), and beta-catenin.	Citric Acid	0-11	glycogen synthase kinase 3 alpha	Homo sapiens	91-99
33332393-7	2020	Citric acid also impacted the upstream regulators of MITF, glycogen synthase kinase 3beta (GSK3beta), and beta-catenin.	Citric Acid	0-11	catenin beta 1	Homo sapiens	106-118
33332393-8	2020	Second, we determined the importance of GSK3beta in the citric acid-mediated regulation of melanin synthesis, using a GSK3beta inhibitor (BIO).	Citric Acid	56-67	glycogen synthase kinase 3 alpha	Homo sapiens	40-48
33332393-9	2020	To the best of our knowledge, this is the first study to show that citric acid regulates melanin synthesis via the GSK3beta/beta-catenin signaling pathway, and that equal amounts of exogenous citric acid exert opposing effects on mouse and human cells.	Citric Acid	67-78	glycogen synthase kinase 3 alpha	Mus musculus	115-123
33332393-9	2020	To the best of our knowledge, this is the first study to show that citric acid regulates melanin synthesis via the GSK3beta/beta-catenin signaling pathway, and that equal amounts of exogenous citric acid exert opposing effects on mouse and human cells.	Citric Acid	67-78	catenin (cadherin associated protein), beta 1	Mus musculus	124-136
33264602-3	2020	SUCLG2-deficient T cells reverted the tricarboxylic acid (TCA) cycle from the oxidative to the reductive direction, accumulated alpha-ketoglutarate, citrate, and acetyl-CoA (AcCoA), and differentiated into pro-inflammatory effector cells.	Citric Acid	149-156	succinate-CoA ligase GDP-forming subunit beta	Homo sapiens	0-6
32456513-0	2020	Citrate pretreatment attenuates hypoxia/reoxygenation-induced cardiomyocyte injury via regulating microRNA-142-3p/Rac1 aix.	Citric Acid	0-7	Rac family small GTPase 1	Rattus norvegicus	114-118
33047344-1	2020	In this study, a beta-cyclodextrin polymer (beta-CDP) was synthesized by pretreating beta-cyclodextrin (beta-CD) with citric acid (CA), and then, chitosan (CTS) and beta-CDP were cross-linked to prepare a biomass-based (CTS/beta-CDP) composite membrane.	Citric Acid	118-129	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	44-51
32907909-8	2020	In healthy controls, GDF-15 levels showed an optimal correlation between EDTA-serum (r=0.975; p<0.001), EDTA-citrate (r=0.972; p<0.001), and serum-citrate (r=0.997; p<0.001) samples.	Citric Acid	109-116	growth differentiation factor 15	Homo sapiens	21-27
32907909-10	2020	Our results demonstrate that citrate samples may be used for the determination of GDF-15 in AF given the positive and good correlation with EDTA and serum matrices.	Citric Acid	29-36	growth differentiation factor 15	Homo sapiens	82-88
32456513-10	2020	Furthermore, Rac1 was target gene of miR-142-3p, and decreased by citrate, in comparison with H/R + miR-142-3p inhibitor group.Conclusion: Taken together, our findings indicated that citrate ameliorates H/R injury-induced cardiomyocytes autophagy by regulating miR-142-3p/Rac1 aix.	Citric Acid	183-190	Rac family small GTPase 1	Rattus norvegicus	272-276
32456513-10	2020	Furthermore, Rac1 was target gene of miR-142-3p, and decreased by citrate, in comparison with H/R + miR-142-3p inhibitor group.Conclusion: Taken together, our findings indicated that citrate ameliorates H/R injury-induced cardiomyocytes autophagy by regulating miR-142-3p/Rac1 aix.	Citric Acid	66-73	Rac family small GTPase 1	Rattus norvegicus	13-17
32456513-10	2020	Furthermore, Rac1 was target gene of miR-142-3p, and decreased by citrate, in comparison with H/R + miR-142-3p inhibitor group.Conclusion: Taken together, our findings indicated that citrate ameliorates H/R injury-induced cardiomyocytes autophagy by regulating miR-142-3p/Rac1 aix.	Citric Acid	183-190	Rac family small GTPase 1	Rattus norvegicus	13-17
33223511-10	2020	Gene set enrichment analysis analysis revealed that TRIM2 may be involved in ubiquitin mediated proteolysis, apoptosis, autophagy and citrate cycle TCA cycle.	Citric Acid	134-141	tripartite motif containing 2	Homo sapiens	52-57
33282912-2	2020	Within the cytosol, citrate is cleaved by ATP citrate lyase (ACLY) into oxaloacetate (OAA) and acetyl-CoA; OAA can be used for neoglucogenesis or in the TCA cycle, while acetyl-CoA is the precursor of some biosynthetic processes, including the synthesis of fatty acids.	Citric Acid	20-27	ATP-citrate synthase	Cricetulus griseus	42-59
33176824-13	2020	CONCLUSIONS: Myoglobin clearance using continuous veno-venous hemodialysis with high cutoff dialyzer and regional citrate anticoagulation is better than that with continuous veno-venous hemodiafiltration with regional citrate anticoagulation.	Citric Acid	114-121	myoglobin	Homo sapiens	13-22
33176824-13	2020	CONCLUSIONS: Myoglobin clearance using continuous veno-venous hemodialysis with high cutoff dialyzer and regional citrate anticoagulation is better than that with continuous veno-venous hemodiafiltration with regional citrate anticoagulation.	Citric Acid	218-225	myoglobin	Homo sapiens	13-22
33079129-1	2020	The Na+-coupled citrate transporter (NaCT/SLC13A5/mINDY) in the liver delivers citrate from the blood into hepatocytes.	Citric Acid	16-23	solute carrier family 13 member 5	Homo sapiens	37-41
33079129-1	2020	The Na+-coupled citrate transporter (NaCT/SLC13A5/mINDY) in the liver delivers citrate from the blood into hepatocytes.	Citric Acid	16-23	solute carrier family 13 member 5	Homo sapiens	42-49
33079129-1	2020	The Na+-coupled citrate transporter (NaCT/SLC13A5/mINDY) in the liver delivers citrate from the blood into hepatocytes.	Citric Acid	16-23	solute carrier family 13 (sodium-dependent citrate transporter), member 5	Mus musculus	50-55
33079129-2	2020	As citrate is a key metabolite and regulator of multiple biochemical pathways, deletion of Slc13a5 in mice protects against diet-induced obesity, diabetes, and metabolic syndrome.	Citric Acid	3-10	solute carrier family 13 (sodium-dependent citrate transporter), member 5	Mus musculus	91-98
33282912-3	2020	Accumulating evidence suggests that citrate is involved in numerous physiological and pathophysiological processes such as inflammation, insulin secretion, neurological disorders, and cancer.	Citric Acid	36-43	insulin	Cricetulus griseus	137-144
33282912-5	2020	At low concentration, citrate increased both histone H4 acetylation and lipid deposition; at high concentration, citrate inhibited both, thus suggesting a crucial role of acetyl-CoA availability, which prompted us to investigate the effect of citrate on ACLY.	Citric Acid	22-29	histone H4	Cricetulus griseus	45-55
33282912-6	2020	In HepG2 cells, the expression of ACLY is correlated with histone acetylation, which, in turn, depends on citrate concentration.	Citric Acid	106-113	ATP citrate lyase	Homo sapiens	34-38
33282912-8	2020	Considering the strong demand for acetyl-CoA but not for OAA in tumor cells, the exogenous citrate would behave like a trojan horse that carries OAA inside the cells and reduces ACLY expression and cellular metabolism.	Citric Acid	91-98	ATP-citrate synthase	Cricetulus griseus	178-182
33282912-2	2020	Within the cytosol, citrate is cleaved by ATP citrate lyase (ACLY) into oxaloacetate (OAA) and acetyl-CoA; OAA can be used for neoglucogenesis or in the TCA cycle, while acetyl-CoA is the precursor of some biosynthetic processes, including the synthesis of fatty acids.	Citric Acid	20-27	ATP-citrate synthase	Cricetulus griseus	61-65
32986444-7	2020	Specifically for citrate buffer, the light-induced formation of H2O2,  OH,  CO2- and formaldehyde was demonstrated.	Citric Acid	17-24	complement C2	Homo sapiens	76-79
32686200-2	2020	Mutations in genes encoding the citric acid cycle enzymes succinate dehydrogenase, fumarate hydratase and malate dehydrogenase all predispose to hereditary tumour syndromes.	Citric Acid	32-43	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	58-81
32686200-2	2020	Mutations in genes encoding the citric acid cycle enzymes succinate dehydrogenase, fumarate hydratase and malate dehydrogenase all predispose to hereditary tumour syndromes.	Citric Acid	32-43	fumarate hydratase	Homo sapiens	83-101
32686200-2	2020	Mutations in genes encoding the citric acid cycle enzymes succinate dehydrogenase, fumarate hydratase and malate dehydrogenase all predispose to hereditary tumour syndromes.	Citric Acid	32-43	malic enzyme 2	Homo sapiens	106-126
32686200-3	2020	The succinate dehydrogenase enzyme complex (SDH) couples the oxidation of succinate to fumarate in the citric acid cycle and the reduction of ubiquinone to ubiquinol in the electron transport chain.	Citric Acid	103-114	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	4-27
32686200-3	2020	The succinate dehydrogenase enzyme complex (SDH) couples the oxidation of succinate to fumarate in the citric acid cycle and the reduction of ubiquinone to ubiquinol in the electron transport chain.	Citric Acid	103-114	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	44-47
33204395-6	2020	In LPS-triggered U937 cells, it inhibited NF-kappaB, a key transcription factor in inflammatory cascade, regulating the expression of both the mitochondrial citrate carrier and the ATP citrate lyase genes.	Citric Acid	157-164	nuclear factor kappa B subunit 1	Homo sapiens	42-51
32806244-0	2020	One-pot synthesized citric acid-modified bimetallic PtNi hollow nanospheres as peroxidase mimics for colorimetric detection of human serum albumin.	Citric Acid	20-31	albumin	Homo sapiens	133-146
33134464-7	2020	Results: INR-RTF results from adjusted and unadjusted citrate blood specimens showed a strong correlation (R2 = 0.8226, p < 0.0001).	Citric Acid	54-61	ATPase H+ transporting V0 subunit a2	Homo sapiens	13-16
33115417-13	2020	Additionally, cell cycle, pyrimidine metabolism, DNA replication, p53 signaling pathway, ubiquitin-mediated proteolysis, the citrate cycle TCA cycle may be the key pathway by which E2F2 participates in the initial and progression of HCC.	Citric Acid	125-132	E2F transcription factor 2	Homo sapiens	181-185
33104522-5	2020	Ccl2 overexpression decreased the lifespan of the progeroid mice and induced the dysregulation of glycolysis, the citric acid cycle and one-carbon metabolism in skeletal muscle, driving dynamic changes in energy metabolism and DNA methylation.	Citric Acid	114-125	chemokine (C-C motif) ligand 2	Mus musculus	0-4
33304224-4	2020	This work presents a crystallographic study of Nd5.8WO12-delta and molybdenum-substituted Nd5.7W0.75Mo0.25O12-delta prepared by the citrate complexation route.	Citric Acid	132-139	mitochondrially encoded NADH dehydrogenase 5	Homo sapiens	47-50
33304224-4	2020	This work presents a crystallographic study of Nd5.8WO12-delta and molybdenum-substituted Nd5.7W0.75Mo0.25O12-delta prepared by the citrate complexation route.	Citric Acid	132-139	mitochondrially encoded NADH dehydrogenase 5	Homo sapiens	90-93
33096779-1	2020	Hydroxycitrate (HCA), a main organic acid component of the fruit rind of Garcinia cambogia, is a natural citrate analog that can inhibit the ATP citrate lyase (ACLY) enzyme with a consequent reduction of inflammatory mediators (i.e., nitric oxide (NO), reactive oxygen species (ROS), and prostaglandin E2 (PGE2)) levels.	Citric Acid	7-14	ATP citrate lyase	Homo sapiens	141-158
33096779-1	2020	Hydroxycitrate (HCA), a main organic acid component of the fruit rind of Garcinia cambogia, is a natural citrate analog that can inhibit the ATP citrate lyase (ACLY) enzyme with a consequent reduction of inflammatory mediators (i.e., nitric oxide (NO), reactive oxygen species (ROS), and prostaglandin E2 (PGE2)) levels.	Citric Acid	7-14	ATP citrate lyase	Homo sapiens	160-164
33026009-1	2020	In this work, uniform ultra-small core-shell Au-Pt nanoparticles (denoted as USCS Au-Pt NPs) with Au-decorated Pt surfaces are successfully prepared by Fe(ii)-assisted one-pot co-reduction of Au(iii) ions and Pt(ii) ions in a citrate solution.	Citric Acid	226-233	general transcription factor IIE subunit 1	Homo sapiens	152-158
32986054-5	2020	In this study, we report on maghemite nanoparticles functionalized with citrate-, dextran- and polyethylene glycol coatings and their interaction with the clotting protein fibrinogen.	Citric Acid	72-79	fibrinogen beta chain	Homo sapiens	172-182
32535467-4	2020	The S-Ag-NPs were prepared by sulfidation of citrate-coated silver nanoparticles (Cit-Ag-NPs).	Citric Acid	45-52	S-antigen visual arrestin	Homo sapiens	4-8
32535467-11	2020	For S-Ag-NPs stabilized by a low amount of citrate, we expect longer residence times in the water phase of rivers and thus higher risk for aquatic organisms.	Citric Acid	43-50	S-antigen visual arrestin	Homo sapiens	4-8
32986054-8	2020	In addition, bioconjugates of fibrinogen with dextran- and citrate-coated NPs interact with integrin-containing lipid bilayer, especially upon treatment with divalent ions, whereas PEG-coating reveals minor interaction.	Citric Acid	59-66	fibrinogen beta chain	Homo sapiens	30-40
32692565-5	2020	Notably, citrate metabolism and transportation in cell mitochondria were significantly influenced by BBR, which led to the blocked biosynthesis of the defined fatty acids (FAs) through the regulation of ACLY, ACO1 and SLC13A5.	Citric Acid	9-16	ATP citrate lyase	Homo sapiens	203-207
32713659-1	2020	BACKGROUND: The ACO2 gene encodes mitochondrial aconitase, the enzyme involved in the second step of the tricarboxylic acid cycle, catalyzing the interconversion of citrate into isocitrate.	Citric Acid	165-172	aconitase 2	Homo sapiens	16-20
32713659-1	2020	BACKGROUND: The ACO2 gene encodes mitochondrial aconitase, the enzyme involved in the second step of the tricarboxylic acid cycle, catalyzing the interconversion of citrate into isocitrate.	Citric Acid	165-172	aconitase 2	Homo sapiens	34-57
33083382-4	2020	Citric acid had the lowest IC50 values for alpha-amylase and alpha-glucosidase activities 0.64+-0.04 muM/mL and 8.95+-0.05 muM/mL, respectively, and thus exhibited the strongest antidiabetic effect.	Citric Acid	0-11	sucrase-isomaltase	Homo sapiens	61-78
32969324-5	2022	Therefore, in order to address this mechanism leading to cancer, the binding efficiency of potential human FH inhibitor citrate to zebrafish fh has been extensively analysed in this study by molecular docking and simulation experiments followed by quantification of fumarate hydratase enzyme activity to validate and confirm the findings.	Citric Acid	120-127	fumarate hydratase	Danio rerio	266-284
32946687-10	2020	Furthermore, glutamine restriction suppressed isocitrate dehydrogenase 1 (IDH1) gene expression, an enzyme which produces citrate for lipid synthesis.	Citric Acid	49-56	isocitrate dehydrogenase 1 (NADP+), soluble	Mus musculus	74-78
32786449-5	2020	Pronounced differences in aggregation and aggregate stability were observed with silver nanoparticles (citrate-coated) with an initial hydrodynamic diameter (Dh) of 24.6 +- 0.4 nm examined under fasted (pH 2) and fed (pH 5) gastric conditions using nanoparticle tracking analysis (NTA) for size distributions and transmission electron microscopy with energy dispersive X-ray spectroscopy (TEM-EDX) for morphology and elemental composition.	Citric Acid	103-110	phenylalanine hydroxylase	Homo sapiens	203-205
32786449-5	2020	Pronounced differences in aggregation and aggregate stability were observed with silver nanoparticles (citrate-coated) with an initial hydrodynamic diameter (Dh) of 24.6 +- 0.4 nm examined under fasted (pH 2) and fed (pH 5) gastric conditions using nanoparticle tracking analysis (NTA) for size distributions and transmission electron microscopy with energy dispersive X-ray spectroscopy (TEM-EDX) for morphology and elemental composition.	Citric Acid	103-110	phenylalanine hydroxylase	Homo sapiens	218-220
32856916-1	2020	G-protein-coupled receptor SUCNR1 (succinate receptor 1 or GPR91) senses the citric cycle intermediate succinate and is implicated in various pathological conditions such as rheumatoid arthritis, liver fibrosis, or obesity.	Citric Acid	77-83	succinate receptor 1	Homo sapiens	27-33
32856916-1	2020	G-protein-coupled receptor SUCNR1 (succinate receptor 1 or GPR91) senses the citric cycle intermediate succinate and is implicated in various pathological conditions such as rheumatoid arthritis, liver fibrosis, or obesity.	Citric Acid	77-83	succinate receptor 1	Homo sapiens	35-55
32856916-1	2020	G-protein-coupled receptor SUCNR1 (succinate receptor 1 or GPR91) senses the citric cycle intermediate succinate and is implicated in various pathological conditions such as rheumatoid arthritis, liver fibrosis, or obesity.	Citric Acid	77-83	succinate receptor 1	Homo sapiens	59-64
33163409-2	2020	In particular, AR signaling influences the fates of citrate that uniquely characterizes normal and malignant prostatic metabolism (i.e., mitochondrial export and extracellular secretion in normal prostate, mitochondrial retention and oxidation to support oxidative phenotype of primary PCa, and extra-mitochondrial interconversion into acetyl-CoA for fatty acid synthesis and epigenetics in the advanced PCa).	Citric Acid	52-59	androgen receptor	Homo sapiens	15-17
32600733-9	2020	Evaluation of the cell behaviour following exposure to Zn-Hap and cit-Hap strongly suggested a synergistic effect of citrate and Zn in cit-Zn-Hap NPs towards the induction of the osteogenic commitment and functionality of BMSCs.	Citric Acid	117-124	reticulon 3	Homo sapiens	58-61
32600733-9	2020	Evaluation of the cell behaviour following exposure to Zn-Hap and cit-Hap strongly suggested a synergistic effect of citrate and Zn in cit-Zn-Hap NPs towards the induction of the osteogenic commitment and functionality of BMSCs.	Citric Acid	117-124	reticulon 3	Homo sapiens	70-73
32600733-9	2020	Evaluation of the cell behaviour following exposure to Zn-Hap and cit-Hap strongly suggested a synergistic effect of citrate and Zn in cit-Zn-Hap NPs towards the induction of the osteogenic commitment and functionality of BMSCs.	Citric Acid	117-124	reticulon 3	Homo sapiens	70-73
32574661-2	2020	Furthermore, sleep disorders can alter the function of alpha-KGDH (alpha-ketoglutarate dehydrogenase), which is involved in the citric acid cycle.	Citric Acid	128-139	oxoglutarate dehydrogenase	Rattus norvegicus	67-100
32822537-4	2020	AK3 plays an important role in the citric acid cycle where it is responsible for GTP/GDP recycling.	Citric Acid	35-46	adenylate kinase 3	Homo sapiens	0-3
32687811-3	2020	1.0M citric acid dissolved in 5% acetic acid (C3A) provides comparable results following both SDS-PAGE and two-dimensional gel electrophoresis, while also eliminating waste removal costs.	Citric Acid	5-16	complement C3	Homo sapiens	46-49
32692565-5	2020	Notably, citrate metabolism and transportation in cell mitochondria were significantly influenced by BBR, which led to the blocked biosynthesis of the defined fatty acids (FAs) through the regulation of ACLY, ACO1 and SLC13A5.	Citric Acid	9-16	aconitase 1	Homo sapiens	209-213
32692565-5	2020	Notably, citrate metabolism and transportation in cell mitochondria were significantly influenced by BBR, which led to the blocked biosynthesis of the defined fatty acids (FAs) through the regulation of ACLY, ACO1 and SLC13A5.	Citric Acid	9-16	solute carrier family 13 member 5	Homo sapiens	218-225
32876527-2	2020	It has been shown that mitochondrial metabolites, transported by the citrate carrier (CIC), dicarboxylate carrier (DIC), oxoglutarate carrier (OGC), and mitochondrial pyruvate carrier (MPC) play a vital role in the regulation of glucose-stimulated insulin secretion (GSIS).	Citric Acid	69-76	insulin	Homo sapiens	248-255
32819574-5	2020	Finally, we turned our attention to inflammatory mediators derived from the cleavage of citrate catalyzed by ACLY: prostaglandin E2, nitric oxide and reactive oxygen species.	Citric Acid	88-95	ATP citrate lyase	Mus musculus	109-113
32505811-6	2020	Consumption of CKRT resources can be made more efficient by optimizing circuit anticoagulation to preserve filters, extending use of each vascular access, lowering blood flows to reduce citrate consumption, moderating the CKRT intensity to conserve fluids, or running accelerated KRT at higher clearance to treat more patients per machine.	Citric Acid	186-193	keratin 126, pseudogene	Homo sapiens	16-19
32634519-1	2020	Solute carrier family 13 member 5 (SLC13A5) is an uptake transporter mainly expressed in the liver and transports citrate from blood circulation into hepatocytes.	Citric Acid	114-121	solute carrier family 13 member 5	Homo sapiens	0-33
32744123-4	2020	HLRCC results from germline mutations in the FH gene, which encodes the citric acid cycle enzyme fumarate hydratase (FH).	Citric Acid	72-83	fumarate hydratase	Homo sapiens	45-47
32744123-4	2020	HLRCC results from germline mutations in the FH gene, which encodes the citric acid cycle enzyme fumarate hydratase (FH).	Citric Acid	72-83	fumarate hydratase	Homo sapiens	97-115
32744123-4	2020	HLRCC results from germline mutations in the FH gene, which encodes the citric acid cycle enzyme fumarate hydratase (FH).	Citric Acid	72-83	fumarate hydratase	Homo sapiens	117-119
32498134-9	2020	This unique localization and activity of Acot9 directed acetyl-CoA away from protein lysine acetylation and towards the citric acid (TCA) cycle.	Citric Acid	120-131	acyl-CoA thioesterase 9	Mus musculus	41-46
32682952-0	2020	Disruption of the sodium-dependent citrate transporter SLC13A5 in mice causes alterations in brain citrate levels and neuronal network excitability in the hippocampus.	Citric Acid	35-42	solute carrier family 13 (sodium-dependent citrate transporter), member 5	Mus musculus	55-62
32682952-5	2020	The experiments revealed an increased propensity for epileptic seizures, proepileptogenic neuronal excitability changes in the hippocampus, and significant citrate alterations in the CSF and brain tissue of Slc13a5 deficient mice, which may underlie the neurological abnormalities.	Citric Acid	156-163	solute carrier family 13 (sodium-dependent citrate transporter), member 5	Mus musculus	207-214
32682952-6	2020	These data demonstrate that SLC13A5 is involved in brain citrate regulation and suggest that abnormalities in this regulation can induce seizures.	Citric Acid	57-64	solute carrier family 13 (sodium-dependent citrate transporter), member 5	Mus musculus	28-35
32682952-7	2020	The present study is the first to (i) establish the Slc13a5-knockout mouse model as a helpful tool to study the neuronal functions of NaCT and characterize the molecular mechanisms by which functional deficiency of this citrate transporter causes epilepsy and impairs neuronal function; (ii) evaluate all hypotheses that have previously been suggested on theoretical grounds to explain the neurological phenotype of SLC13A5 mutations; and (iii) indicate that alterations in brain citrate levels result in neuronal network excitability and increased seizure propensity.	Citric Acid	220-227	solute carrier family 13 (sodium-dependent citrate transporter), member 5	Mus musculus	52-59
32682952-7	2020	The present study is the first to (i) establish the Slc13a5-knockout mouse model as a helpful tool to study the neuronal functions of NaCT and characterize the molecular mechanisms by which functional deficiency of this citrate transporter causes epilepsy and impairs neuronal function; (ii) evaluate all hypotheses that have previously been suggested on theoretical grounds to explain the neurological phenotype of SLC13A5 mutations; and (iii) indicate that alterations in brain citrate levels result in neuronal network excitability and increased seizure propensity.	Citric Acid	220-227	solute carrier family 13 (sodium-dependent citrate transporter), member 5	Mus musculus	134-138
32634519-1	2020	Solute carrier family 13 member 5 (SLC13A5) is an uptake transporter mainly expressed in the liver and transports citrate from blood circulation into hepatocytes.	Citric Acid	114-121	solute carrier family 13 member 5	Homo sapiens	35-42
32859092-4	2020	Among these alterations, an important role is played by two mutant enzymes of the citric acid cycle, isocitrate dehydrogenase (IDH), IDH1 and IDH2, occurring in about 20% of AMLs, which leads to the production of an oncogenic metabolite R-2-hydroxy-glutarate (R-2-HG); this causes a DNA hypermethylation and an inhibition of hematopoietic stem cell differentiation.	Citric Acid	82-93	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	101-125
32859092-4	2020	Among these alterations, an important role is played by two mutant enzymes of the citric acid cycle, isocitrate dehydrogenase (IDH), IDH1 and IDH2, occurring in about 20% of AMLs, which leads to the production of an oncogenic metabolite R-2-hydroxy-glutarate (R-2-HG); this causes a DNA hypermethylation and an inhibition of hematopoietic stem cell differentiation.	Citric Acid	82-93	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	127-130
32859092-4	2020	Among these alterations, an important role is played by two mutant enzymes of the citric acid cycle, isocitrate dehydrogenase (IDH), IDH1 and IDH2, occurring in about 20% of AMLs, which leads to the production of an oncogenic metabolite R-2-hydroxy-glutarate (R-2-HG); this causes a DNA hypermethylation and an inhibition of hematopoietic stem cell differentiation.	Citric Acid	82-93	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	133-137
32859092-4	2020	Among these alterations, an important role is played by two mutant enzymes of the citric acid cycle, isocitrate dehydrogenase (IDH), IDH1 and IDH2, occurring in about 20% of AMLs, which leads to the production of an oncogenic metabolite R-2-hydroxy-glutarate (R-2-HG); this causes a DNA hypermethylation and an inhibition of hematopoietic stem cell differentiation.	Citric Acid	82-93	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	142-146
32825193-1	2020	We investigated the opportunities for obtaining hexaferrites Pb1-xLaxFe12-xZnxO19 (x = 0-1) from citrate-glycerin gel and showed that synthesis occurs via the formation of the Fe3O4 phase; products with a small amount of hematite impurity Fe2O3 can be obtained after firing at 800 to 900  C with 0 <= x <= 0.5.	Citric Acid	97-104	submaxillary gland androgen regulated protein 3A	Homo sapiens	61-64
32849657-0	2020	Cytoplasmic Citrate Flux Modulates the Immune Stimulatory NKG2D Ligand MICA in Cancer Cells.	Citric Acid	12-19	killer cell lectin like receptor K1	Homo sapiens	58-63
32849657-0	2020	Cytoplasmic Citrate Flux Modulates the Immune Stimulatory NKG2D Ligand MICA in Cancer Cells.	Citric Acid	12-19	MHC class I polypeptide-related sequence A	Homo sapiens	71-75
32849657-8	2020	Cells with constitutive high MICA expression showed enhanced spare respiratory capacity and elevated mitochondrial efflux of citrate, determined by extracellular flux analysis and metabolomics.	Citric Acid	125-132	MHC class I polypeptide-related sequence A	Homo sapiens	29-33
32849657-9	2020	MICA expression was reduced by inhibitors of mitochondrial function, FCCP and etomoxir e.g., and depended on conversion of citrate to acetyl-CoA and oxaloacetate by ATP citrate lyase, which was also observed in several cancer cell types.	Citric Acid	123-130	MHC class I polypeptide-related sequence A	Homo sapiens	0-4
32849657-9	2020	MICA expression was reduced by inhibitors of mitochondrial function, FCCP and etomoxir e.g., and depended on conversion of citrate to acetyl-CoA and oxaloacetate by ATP citrate lyase, which was also observed in several cancer cell types.	Citric Acid	123-130	ATP citrate lyase	Homo sapiens	165-182
32849657-11	2020	We identify mitochondria and cytoplasmic citrate as key regulators of constitutive MICA expression and we propose that metabolic reprogramming of certain cancer cells facilitates MICA expression and NKG2D-mediated immune recognition.	Citric Acid	41-48	MHC class I polypeptide-related sequence A	Homo sapiens	83-87
30979692-13	2020	Remarkably, all the primary metabolites belonging to the Krebs Cycle (citric acid, fumaric acid, succinic acid, pyruvic acid, malic acid and citramalic acid, an analog of malic acid) were positively correlated with BDNF activity.	Citric Acid	70-81	brain derived neurotrophic factor	Homo sapiens	215-219
32770017-5	2020	F. gigantica encodes a single cytosolic MDH, a key enzyme of the citric acid cycle.	Citric Acid	65-76	malate dehydrogenase 2	Homo sapiens	40-43
32802835-9	2020	Moreover, the PPI network (containing 237 edges and 170 nodes) with the top module significantly enriched in 4 BPs (tricarboxylic acid metabolic process, citrate metabolic process, tricarboxylic acid cycle, and aerobic respiration) and 3 pathways (citrate cycle, malaria parasite metabolic pathway, and AGE-RAGE signaling pathway in diabetic complications) was constructed.	Citric Acid	154-161	advanced glycosylation end-product specific receptor	Homo sapiens	307-311
32802835-9	2020	Moreover, the PPI network (containing 237 edges and 170 nodes) with the top module significantly enriched in 4 BPs (tricarboxylic acid metabolic process, citrate metabolic process, tricarboxylic acid cycle, and aerobic respiration) and 3 pathways (citrate cycle, malaria parasite metabolic pathway, and AGE-RAGE signaling pathway in diabetic complications) was constructed.	Citric Acid	248-255	advanced glycosylation end-product specific receptor	Homo sapiens	307-311
32449285-1	2020	The mitochondrial aconitase gene (ACO2) encodes an enzyme that catalyzes the conversion of citrate to isocitrate in the tricarboxylic acid cycle.	Citric Acid	91-98	aconitase 2	Homo sapiens	4-27
32449285-1	2020	The mitochondrial aconitase gene (ACO2) encodes an enzyme that catalyzes the conversion of citrate to isocitrate in the tricarboxylic acid cycle.	Citric Acid	91-98	aconitase 2	Homo sapiens	34-38
32789178-3	2020	Upon mitochondrial stress, the impaired tricarboxylic acid cycle results in a decreased level of citrate, which accounts for reduced production of acetyl-CoA and consequently induces nuclear accumulation of the NuRD and a homeodomain-containing transcription factor DVE-1, thereby enabling decreased histone acetylation and chromatin reorganization.	Citric Acid	97-104	Homeobox protein dve-1	Caenorhabditis elegans	266-271
32722640-5	2020	The increased levels of fumaric acid, malic acid, oxaloacetic acid and citric acid related to the citric acid cycle pathway after alpha-MSH treatment suggested enhanced energy metabolism.	Citric Acid	71-82	STAM binding protein	Mus musculus	130-139
32722640-5	2020	The increased levels of fumaric acid, malic acid, oxaloacetic acid and citric acid related to the citric acid cycle pathway after alpha-MSH treatment suggested enhanced energy metabolism.	Citric Acid	98-109	STAM binding protein	Mus musculus	130-139
32801864-1	2020	Purpose: Citrate synthase (CS) is a rate-limiting enzyme in the citrate cycle and is capable of catalyzing oxaloacetate and acetyl-CoA to citrate.	Citric Acid	64-71	citrate synthase	Homo sapiens	9-25
32801864-1	2020	Purpose: Citrate synthase (CS) is a rate-limiting enzyme in the citrate cycle and is capable of catalyzing oxaloacetate and acetyl-CoA to citrate.	Citric Acid	64-71	citrate synthase	Homo sapiens	27-29
32801864-1	2020	Purpose: Citrate synthase (CS) is a rate-limiting enzyme in the citrate cycle and is capable of catalyzing oxaloacetate and acetyl-CoA to citrate.	Citric Acid	138-145	citrate synthase	Homo sapiens	9-25
32801864-1	2020	Purpose: Citrate synthase (CS) is a rate-limiting enzyme in the citrate cycle and is capable of catalyzing oxaloacetate and acetyl-CoA to citrate.	Citric Acid	138-145	citrate synthase	Homo sapiens	27-29
32639996-0	2020	The membrane protein ANKH is crucial for bone mechanical performance by mediating cellular export of citrate and ATP.	Citric Acid	101-108	progressive ankylosis	Mus musculus	21-25
32639996-5	2020	Mice lacking functional Ank (Ankank/ank mice) had plasma citrate concentrations that were 65% lower than those detected in wild type control animals.	Citric Acid	57-64	progressive ankylosis	Mus musculus	24-27
32639996-5	2020	Mice lacking functional Ank (Ankank/ank mice) had plasma citrate concentrations that were 65% lower than those detected in wild type control animals.	Citric Acid	57-64	progressive ankylosis	Mus musculus	32-35
32639996-6	2020	Consequently, citrate excretion via the urine was substantially reduced in Ankank/ank mice.	Citric Acid	14-21	progressive ankylosis	Mus musculus	78-81
32639996-7	2020	Citrate was even undetectable in the urine of a human patient lacking functional ANKH.	Citric Acid	0-7	ANKH inorganic pyrophosphate transport regulator	Homo sapiens	81-85
32639996-8	2020	The hydroxyapatite of Ankank/ank mice contained dramatically reduced levels of both, citrate and PPi and displayed diminished strength.	Citric Acid	85-92	progressive ankylosis	Mus musculus	25-28
32639996-9	2020	Our results show that ANKH is a critical contributor to extracellular citrate and PPi homeostasis and profoundly affects bone matrix composition and, consequently, bone quality.	Citric Acid	70-77	progressive ankylosis	Mus musculus	22-26
32671252-4	2020	In this work, novel, ultrasensitive sandwich-type portable bio device based on citrate-capped silver nanoparticles (Citrate-AgNPs) modified graphene quantum dots (GQDs) nano ink for detection of Prostate specific antigen (PSA) was fabricated.	Citric Acid	79-86	kallikrein related peptidase 3	Homo sapiens	195-220
32671252-4	2020	In this work, novel, ultrasensitive sandwich-type portable bio device based on citrate-capped silver nanoparticles (Citrate-AgNPs) modified graphene quantum dots (GQDs) nano ink for detection of Prostate specific antigen (PSA) was fabricated.	Citric Acid	79-86	kallikrein related peptidase 3	Homo sapiens	222-225
32641713-6	2020	Oxidized ATM up-regulates GLUT1, PKM2, and PDHa expressions to enhance the uptake of glucose and production of pyruvate rather than lactate products, which facilitates glycolytic flux to mitochondrial pyruvate and citrate, thus resulting in accumulation of cytoplasmic acetyl-CoA instead of the tricarboxylic acid (TCA) cycle by regulating ATP-citrate lyase (ACLY) activity.	Citric Acid	214-221	ATM serine/threonine kinase	Homo sapiens	9-12
32641713-6	2020	Oxidized ATM up-regulates GLUT1, PKM2, and PDHa expressions to enhance the uptake of glucose and production of pyruvate rather than lactate products, which facilitates glycolytic flux to mitochondrial pyruvate and citrate, thus resulting in accumulation of cytoplasmic acetyl-CoA instead of the tricarboxylic acid (TCA) cycle by regulating ATP-citrate lyase (ACLY) activity.	Citric Acid	214-221	solute carrier family 2 member 1	Homo sapiens	26-31
32641713-6	2020	Oxidized ATM up-regulates GLUT1, PKM2, and PDHa expressions to enhance the uptake of glucose and production of pyruvate rather than lactate products, which facilitates glycolytic flux to mitochondrial pyruvate and citrate, thus resulting in accumulation of cytoplasmic acetyl-CoA instead of the tricarboxylic acid (TCA) cycle by regulating ATP-citrate lyase (ACLY) activity.	Citric Acid	214-221	pyruvate dehydrogenase E1 subunit alpha 1	Homo sapiens	43-47
33988647-11	2020	CONCLUSION: The supplementation of SOD3 (300 IU/mL) in Tris citric acid extender improves both in vitro quality and in vivo fertility of buffalo bull spermatozoa.	Citric Acid	60-71	extracellular superoxide dismutase [Cu-Zn]	Bubalus bubalis	35-39
32777080-10	2020	For the 2014-17 period, the IRR for mortality with citric acid [adjusted IRR 0.94 (95% CI 0.90-0.99)] and with hydrochloric acid [adjusted IRR 0.86 (95% CI 0.79-0.94)] were significantly lower than with acetic acid.	Citric Acid	51-62	insulin receptor related receptor	Homo sapiens	28-31
32777080-10	2020	For the 2014-17 period, the IRR for mortality with citric acid [adjusted IRR 0.94 (95% CI 0.90-0.99)] and with hydrochloric acid [adjusted IRR 0.86 (95% CI 0.79-0.94)] were significantly lower than with acetic acid.	Citric Acid	51-62	insulin receptor related receptor	Homo sapiens	73-76
32777080-10	2020	For the 2014-17 period, the IRR for mortality with citric acid [adjusted IRR 0.94 (95% CI 0.90-0.99)] and with hydrochloric acid [adjusted IRR 0.86 (95% CI 0.79-0.94)] were significantly lower than with acetic acid.	Citric Acid	51-62	insulin receptor related receptor	Homo sapiens	73-76
32278414-2	2020	In this work, we present a simple and fast colorimetric method for CRP detection that employs citrate-capped gold nanoparticles (AuNPs) and a CRP-binding aptamer as sensing elements.	Citric Acid	94-101	C-reactive protein	Homo sapiens	67-70
32448086-1	2021	ATP citrate lyase (ACLY) is an important enzyme that catalyzes the conversion of citrate to acetyl-CoA in normal cells, facilitating the de novo fatty acid synthesis.	Citric Acid	4-11	ATP citrate lyase	Homo sapiens	19-23
32151988-1	2020	The capability of citrate-stabilized gold nanoparticles (AuNps) has been explored for the inhibition of amyloid fibrillation of human gammaD-crystallin (HGD), a major protein of eye lens.	Citric Acid	18-25	homogentisate 1,2-dioxygenase	Homo sapiens	153-156
32448086-3	2021	Since ACLY-mediated conversion of citrate to acetyl-CoA constitutes the basis for fatty acid synthesis, ACLY seems to be quite an unexplored and promising therapeutic target for anticancer drug design.	Citric Acid	34-41	ATP citrate lyase	Homo sapiens	6-10
31856334-0	2020	Interleukin-5 drives glycolysis and reactive oxygen species-dependent citric acid cycling by eosinophils.	Citric Acid	70-81	interleukin 5	Homo sapiens	0-13
32212192-1	2020	Mitochondrial aconitase (Aco2) catalyzes the conversion of citrate to isocitrate in the TCA cycle, which produces NADH and FADH2, driving synthesis of ATP through OXPHOS.	Citric Acid	59-66	aconitase 2, mitochondrial	Mus musculus	25-29
32538058-3	2020	METHODS: In this prospective study, thrombin generation was measured in twenty-fold repetitions in 3.2% citrate PPP obtained from male healthy blood donors aged 19 - 39 years (n = 54 donations).	Citric Acid	104-111	coagulation factor II, thrombin	Homo sapiens	36-44
32366855-7	2020	We found that the inhibitory effect of TPL on metabolism occurs mainly on the step from citrate to alpha-ketoglutarate or vice versa.	Citric Acid	88-95	BPI fold containing family A, member 5	Mus musculus	39-42
32671252-4	2020	In this work, novel, ultrasensitive sandwich-type portable bio device based on citrate-capped silver nanoparticles (Citrate-AgNPs) modified graphene quantum dots (GQDs) nano ink for detection of Prostate specific antigen (PSA) was fabricated.	Citric Acid	116-123	kallikrein related peptidase 3	Homo sapiens	195-220
32671252-4	2020	In this work, novel, ultrasensitive sandwich-type portable bio device based on citrate-capped silver nanoparticles (Citrate-AgNPs) modified graphene quantum dots (GQDs) nano ink for detection of Prostate specific antigen (PSA) was fabricated.	Citric Acid	116-123	kallikrein related peptidase 3	Homo sapiens	222-225
31094281-7	2020	C-reactive protein and renal function, glucose and lipid profile measurements were performed in sera; klotho was determined in citrate-treated plasma samples.	Citric Acid	127-134	klotho	Homo sapiens	102-108
32472000-6	2020	CD spectroscopy revealed that the immobilized bFGF initially exhibited secondary structure rich in alpha-helix and that the spectrum was gradually transformed to exhibit the formation of beta-strands upon exposure to citrate buffer solution, approaching to the spectrum of native bFGF.	Citric Acid	217-224	fibroblast growth factor 2	Homo sapiens	46-50
32472000-7	2020	The rate of hMSC proliferation was 1.2-fold higher on the bFGF-immobilized surface treated with in situ citrate buffer, compared to the polystyrene surface.	Citric Acid	104-111	fibroblast growth factor 2	Homo sapiens	58-62
32444674-6	2020	Metformin inhibits the expression of the plasma membrane citrate transporter NaCT in HepG2 cells and decreases cellular levels of citrate.	Citric Acid	57-64	solute carrier family 13 member 5	Homo sapiens	77-81
32444674-12	2020	Citrate is known to suppress glycolysis by inhibiting phosphofructokinase-1 and activate gluconeogenesis by stimulating fructose-1,6-bisphophatase; therefore, the decrease in cellular levels of citrate would stimulate glycolysis and inhibit gluconeogenesis.	Citric Acid	0-7	phosphofructokinase, muscle	Homo sapiens	54-75
32508637-5	2020	ZIP-1 knockdown and overexpression confirmed that melatonin specifically upregulated ZIP-1 to rescue citrate levels and bone mass.	Citric Acid	101-108	solute carrier family 39 (zinc transporter), member 1	Mus musculus	0-5
32508637-5	2020	ZIP-1 knockdown and overexpression confirmed that melatonin specifically upregulated ZIP-1 to rescue citrate levels and bone mass.	Citric Acid	101-108	solute carrier family 39 (zinc transporter), member 1	Mus musculus	85-90
32420483-6	2020	Three of them (Y682, Y252, Y227) can be also phosphorylated by Src and they are located in catalytic, citrate binding and ATP binding domains, respectively.	Citric Acid	102-109	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	63-66
32278088-4	2020	While the buildup of NADPH in chloroplasts provides operation of the malate valve leading to establishment of NADH/NAD+ ratios in different cell compartments, the production of NADH by mitochondria drives citrate export by establishing conditions for the operation of the citrate valve.	Citric Acid	205-212	2,4-dienoyl-CoA reductase 1	Homo sapiens	21-26
32278088-4	2020	While the buildup of NADPH in chloroplasts provides operation of the malate valve leading to establishment of NADH/NAD+ ratios in different cell compartments, the production of NADH by mitochondria drives citrate export by establishing conditions for the operation of the citrate valve.	Citric Acid	272-279	2,4-dienoyl-CoA reductase 1	Homo sapiens	21-26
32278736-10	2020	The evolution of several biological parameters seemed favourable over the citrate period: increase in pre-dialysis serum bicarbonate, stability of plasma hemoglobin and decrease in erythropoietin resistance index (ERI).	Citric Acid	74-81	erythropoietin	Homo sapiens	181-195
32397894-3	2020	In the manufacturing process of fractionated antithrombin from plasma, heat treatment, citrate, and freeze drying speed up the transformation of native antithrombin to latent antithrombin.	Citric Acid	87-94	serpin family C member 1	Homo sapiens	45-57
32397894-3	2020	In the manufacturing process of fractionated antithrombin from plasma, heat treatment, citrate, and freeze drying speed up the transformation of native antithrombin to latent antithrombin.	Citric Acid	87-94	serpin family C member 1	Homo sapiens	152-164
32397894-3	2020	In the manufacturing process of fractionated antithrombin from plasma, heat treatment, citrate, and freeze drying speed up the transformation of native antithrombin to latent antithrombin.	Citric Acid	87-94	serpin family C member 1	Homo sapiens	152-164
32355284-2	2020	In maize, ZmMATE1 confers Al tolerance via Al-activated citrate release, whereby citrate forms non-toxic complexes with Al3+ in the rhizosphere.	Citric Acid	56-63	Protein DETOXIFICATION 42	Zea mays	10-17
31751299-14	2020	ACO1 is an iron-sulfur enzyme in the citric acid cycle that upon loss of an iron-sulfur cluster converts to iron regulatory protein 1 (IRP1).	Citric Acid	37-48	aconitase 1	Homo sapiens	0-4
31751299-14	2020	ACO1 is an iron-sulfur enzyme in the citric acid cycle that upon loss of an iron-sulfur cluster converts to iron regulatory protein 1 (IRP1).	Citric Acid	37-48	aconitase 1	Homo sapiens	108-133
31751299-14	2020	ACO1 is an iron-sulfur enzyme in the citric acid cycle that upon loss of an iron-sulfur cluster converts to iron regulatory protein 1 (IRP1).	Citric Acid	37-48	aconitase 1	Homo sapiens	135-139
31751299-15	2020	With the dysregulation of iron-sulfur cluster formation ACO1 will convert to IRP1 which will decrease the 2-oxglutarate synthesis dysregulating the citric acid cycle and also dysregulating iron metabolism.	Citric Acid	148-159	aconitase 1	Homo sapiens	56-60
31751299-15	2020	With the dysregulation of iron-sulfur cluster formation ACO1 will convert to IRP1 which will decrease the 2-oxglutarate synthesis dysregulating the citric acid cycle and also dysregulating iron metabolism.	Citric Acid	148-159	aconitase 1	Homo sapiens	77-81
32290638-0	2020	Gamma-Aminobutyric Acid Increases Erythropoietin by Activation of Citrate Cycle and Stimulation of Hypoxia-Inducible Factors Expression in Rats.	Citric Acid	66-73	erythropoietin	Rattus norvegicus	34-48
32050063-4	2020	The best results were obtained with citrate-buffered version QuEChERS and a cleanup step, with 150 mg of MgSO4, 50 mg of primary secondary amine (PSA), 50 mg of C18, and 5 mg of carbon.	Citric Acid	36-43	Bardet-Biedl syndrome 9	Homo sapiens	161-164
32317970-2	2020	Renal homeostasis of oxalate and citrate is controlled by complex mechanisms including epithelial transport proteins such as the oxalate transporter, SLC26A6, and the citrate transporters, the SLC13"s.	Citric Acid	33-40	solute carrier family 26 member 6	Homo sapiens	150-157
32317970-6	2020	Our in vitro experiments indicate that the homolog mutations of SLC26A6(D23H/D673N) and SLC26A6(D673N) alone abolished the expression and function of SLC26A6, and impaired the regulation of SLC13-mediated citrate transport by SLC26A6.	Citric Acid	205-212	solute carrier family 26 member 6	Homo sapiens	64-71
32317970-6	2020	Our in vitro experiments indicate that the homolog mutations of SLC26A6(D23H/D673N) and SLC26A6(D673N) alone abolished the expression and function of SLC26A6, and impaired the regulation of SLC13-mediated citrate transport by SLC26A6.	Citric Acid	205-212	solute carrier family 26 member 6	Homo sapiens	88-95
32317970-6	2020	Our in vitro experiments indicate that the homolog mutations of SLC26A6(D23H/D673N) and SLC26A6(D673N) alone abolished the expression and function of SLC26A6, and impaired the regulation of SLC13-mediated citrate transport by SLC26A6.	Citric Acid	205-212	solute carrier family 26 member 6	Homo sapiens	88-95
32317970-6	2020	Our in vitro experiments indicate that the homolog mutations of SLC26A6(D23H/D673N) and SLC26A6(D673N) alone abolished the expression and function of SLC26A6, and impaired the regulation of SLC13-mediated citrate transport by SLC26A6.	Citric Acid	205-212	solute carrier family 26 member 6	Homo sapiens	88-95
32317970-8	2020	Accordingly, the human SLC26A6(D23H/D673N) carrier showed a dramatic reduction in urinary citrate concentrations which resulted in Ca2+-oxalate stones formation, as opposed to the carrier of SLC26A6(R621G).	Citric Acid	90-97	solute carrier family 26 member 6	Homo sapiens	23-30
31630411-11	2020	In addition, baseline levels of four amino acids (ie, glutamate, glutamine, threonine, and glycine) and two organic acids (ie, lactate and citric acid) were significantly different in ILK knockdown compared with wild-type HPDLFs.	Citric Acid	139-150	integrin linked kinase	Homo sapiens	184-187
31630411-13	2020	Among them, four amino acids (ie, glutamate, glutamine, threonine, and glycine) and two organic acids (ie, lactate and citric acid) may be closely linked to ILK.	Citric Acid	119-130	integrin linked kinase	Homo sapiens	157-160
32035259-2	2020	CD44 targeted HA-modified carbon dots (HA-CDs) were synthesized as carrier by one-step hydrothermal treatment within one hour with citric acid and branch-PEI as core carbon source.	Citric Acid	131-142	CD44 antigen	Mus musculus	0-4
32222830-3	2020	Herein, we have developed highly sensitive vertical flow immunokit (VFIK) for the detection of C-reactive protein (CRP), comprising an antibody/citrate conjugated gold nanoparticle in a fixed orientation surface.	Citric Acid	144-151	C-reactive protein	Homo sapiens	95-113
32222830-3	2020	Herein, we have developed highly sensitive vertical flow immunokit (VFIK) for the detection of C-reactive protein (CRP), comprising an antibody/citrate conjugated gold nanoparticle in a fixed orientation surface.	Citric Acid	144-151	C-reactive protein	Homo sapiens	115-118
32230933-3	2020	Milk quality was evaluated in relation to selected negative energy balance (NEB) traits: body condition change (DEC) and milk citric acid content (CAC) after calving.	Citric Acid	126-137	Weaning weight-maternal milk	Bos taurus	121-125
32004824-7	2020	The 2% citric acid solution caused an in vitro decrease of 0.4 Log10 CFU mL-1 of Salmonella and E. coli and on eggs artificially contaminated with E. coli or Salmonella there was a decrease of 0.06 and 0.62 Log10 CFU/egg respectively.	Citric Acid	7-18	L1 cell adhesion molecule	Mus musculus	73-77
33558934-1	2020	Theoretical studies on conformational analysis, geometry optimizations and frequencies for citrate at the MP2/LANL2DZ level portrait it as a promising candidate for a complexing agent for cadmium (II) ion (Cd2+) and cadmium sulfide (CdS).	Citric Acid	91-98	CD2 molecule	Homo sapiens	206-209
32164290-0	2020	Comparative Metabolites and Citrate-Degrading Enzymes Activities in Citrus Fruits Reveal the Role of Balance between ACL and Cyt-ACO in Metabolite Conversions.	Citric Acid	28-35	ATP citrate lyase	Homo sapiens	117-120
32164290-2	2020	ATP-citrate lyase (ACL) and cytosolic aconitase (cyt-ACO) are the two citrate-degrading enzymes that decide the carbon flux towards different metabolite biosynthesis pathways.	Citric Acid	4-11	ATP citrate lyase	Homo sapiens	19-22
32164290-5	2020	The results showed that the correlation between citrate concentration and cyt-ACO or ACL activity varied greatly among cultivars, while the activities of cyt-ACO and ACL had a significantly negative correlation (r = -0.4431).	Citric Acid	48-55	ATP citrate lyase	Homo sapiens	85-88
32164290-8	2020	Taken together, the present study suggested that ACL and cyt-ACO synergistically control the citrate fate for the biosynthesis of other metabolites, but they are not the key determinants for the accumulation of citrate, as well as other metabolites in citrus fruits.	Citric Acid	93-100	ATP citrate lyase	Homo sapiens	49-52
33558934-3	2020	The most stable structures involved the interaction between the LUMO of Cd2+/CdS and the most dense region of the HOMO of the citrate ion.	Citric Acid	126-133	CD2 molecule	Homo sapiens	72-75
31371786-8	2020	We exploited the survival of MCU overexpressing cones to additionally demonstrate that mitochondrial Ca2+ uptake alters the distributions of citric acid cycle intermediates and accelerates recovery kinetics of the cone response to light.	Citric Acid	141-152	mitochondrial calcium uniporter	Danio rerio	29-32
31527857-2	2020	SLC25A1 encodes a mitochondrial citrate carrier, associated mainly with the severe neurometabolic disease combined D-2- and L-2-hydroxyglutaric aciduria (D/L-2-HGA).	Citric Acid	32-39	solute carrier family 25 member 1	Homo sapiens	0-7
31527857-2	2020	SLC25A1 encodes a mitochondrial citrate carrier, associated mainly with the severe neurometabolic disease combined D-2- and L-2-hydroxyglutaric aciduria (D/L-2-HGA).	Citric Acid	32-39	L-2-hydroxyglutarate dehydrogenase	Homo sapiens	156-163
31944402-1	2020	Malic enzyme 1 (Me1), a member of the malic enzymes involving in glycolytic pathway and citric acid cycle, is essential for the energy metabolism and maintenance of intracellular redox balance state, but its physiological role and regulatory mechanism in the uterine decidualization are still unknown.	Citric Acid	88-99	malic enzyme 1	Homo sapiens	16-19
31957331-9	2020	Serum citrate was significantly and negatively associated with MMP-13 (beta -3106.37, P < .05) after adjustment for potential confounders.	Citric Acid	6-13	matrix metallopeptidase 13	Homo sapiens	63-69
31957331-11	2020	CONCLUSION: Serum citrate was negatively associated with knee structural changes including femoral osteophytes, cartilage defects, and BMLs and also serum MMP-13 in patients with knee OA, suggesting that low serum citrate may be a potential indicator for advanced knee OA.	Citric Acid	214-221	matrix metallopeptidase 13	Homo sapiens	155-161
32214246-3	2020	The ATP citrate lyase (ACLY) enzyme cleaves cytosolic citrate to generate acetyl-CoA, and is upregulated after consumption of carbohydrates7.	Citric Acid	8-15	ATP citrate lyase	Mus musculus	23-27
31778962-8	2020	The new CP-ELISA displayed a wide working range (0.10-6.78 mg CP/L) and low sample requirement (2 muL of serum, EDTA-, heparin- or citrate-plasma).	Citric Acid	131-138	ceruloplasmin	Homo sapiens	8-10
33987467-1	2020	The objective of the study was to compare the effect of calcium peroxide and citric acid on the activity of acid phosphatase (ACP), alkaline phosphatase (ALP), and dehydrogenases (DHA) in uncontaminated soil and soil contaminated with petrol.	Citric Acid	77-88	alkaline phosphatase, placental	Homo sapiens	132-152
32115039-3	2020	In the presence of lactate or citrate, the high-pressure processing caused an increase in the surface hydrophobicity and reactive sulfhydryl group, indicating the unfolding of myosin molecule.	Citric Acid	30-37	myosin, heavy chain 7B, cardiac muscle, beta	Gallus gallus	176-182
33987467-1	2020	The objective of the study was to compare the effect of calcium peroxide and citric acid on the activity of acid phosphatase (ACP), alkaline phosphatase (ALP), and dehydrogenases (DHA) in uncontaminated soil and soil contaminated with petrol.	Citric Acid	77-88	alkaline phosphatase, placental	Homo sapiens	154-157
32033248-1	2020	Because of a decreased sensitivity toward insulin, a key regulator of pyruvate dehydrogenase (PDH), Alzheimer"s patients have lower brain glucose utilization with reductions in Tricarboxylic Acid (TCA) cycle metabolites such as citrate, a precursor to n-acetyl-aspartate.	Citric Acid	228-235	insulin	Homo sapiens	42-49
32107402-0	2020	Initial interaction of citrate-coated iron oxide nanoparticles with the glycocalyx of THP-1 monocytes assessed by real-time magnetic particle spectroscopy and electron microscopy.	Citric Acid	23-30	GLI family zinc finger 2	Homo sapiens	86-91
31677912-7	2020	In addition, the effective treatment volume of Pb(II) was elevated to 5029.06 L/m2 by the co-existence of citric acid, since neutral PbHL coordinated with neutral NH2 and cationic PbL- interacted with NH3+ through electrostatic attraction.	Citric Acid	106-117	submaxillary gland androgen regulated protein 3B	Homo sapiens	47-53
31927905-3	2020	The 3-PBA detection was via a direct competition for binding to alkaline phosphatase-embedded nanobodies between free 3-PBA and a 3-PBA-bovine serum albumin conjugate covalently immobilized onto citric acid decorated Nylon nanofibers, which were incorporated on a screen-printed electrode (SPE).	Citric Acid	195-206	albumin	Homo sapiens	143-156
32033248-1	2020	Because of a decreased sensitivity toward insulin, a key regulator of pyruvate dehydrogenase (PDH), Alzheimer"s patients have lower brain glucose utilization with reductions in Tricarboxylic Acid (TCA) cycle metabolites such as citrate, a precursor to n-acetyl-aspartate.	Citric Acid	228-235	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	70-92
32033248-1	2020	Because of a decreased sensitivity toward insulin, a key regulator of pyruvate dehydrogenase (PDH), Alzheimer"s patients have lower brain glucose utilization with reductions in Tricarboxylic Acid (TCA) cycle metabolites such as citrate, a precursor to n-acetyl-aspartate.	Citric Acid	228-235	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	94-97
32108577-5	2020	The objective of this study was to compare the stability of both aPTT and anti-Xa in citrate and CTAD samples, and to determine the effect of delayed centrifugation on both aPTT, anti-Xa results, and PF4 release in citrate samples only.	Citric Acid	215-222	platelet factor 4	Homo sapiens	200-203
31039394-1	2020	Succinate dehydrogenase (SDH) has been classically considered a mitochondrial enzyme with the unique property to participate in both the citric acid cycle and the electron transport chain.	Citric Acid	137-148	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	0-23
31944402-1	2020	Malic enzyme 1 (Me1), a member of the malic enzymes involving in glycolytic pathway and citric acid cycle, is essential for the energy metabolism and maintenance of intracellular redox balance state, but its physiological role and regulatory mechanism in the uterine decidualization are still unknown.	Citric Acid	88-99	malic enzyme 1	Homo sapiens	0-14
31039394-1	2020	Succinate dehydrogenase (SDH) has been classically considered a mitochondrial enzyme with the unique property to participate in both the citric acid cycle and the electron transport chain.	Citric Acid	137-148	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	25-28
31979010-7	2020	H3Cit was also associated with P-selectin expression in response to thrombin-receptor activating peptide (p = 0.048) and AA (p = 0.032).	Citric Acid	0-5	selectin P	Homo sapiens	31-41
31947614-1	2020	The Drosophila melanogaster DmATPCL gene encodes for the human ATP Citrate Lyase (ACL) ortholog, a metabolic enzyme that from citrate generates glucose-derived Acetyl-CoA, which fuels central biochemical reactions such as the synthesis of fatty acids, cholesterol and acetylcholine, and the acetylation of proteins and histones.	Citric Acid	126-133	ATP citrate lyase	Drosophila melanogaster	28-35
31947614-1	2020	The Drosophila melanogaster DmATPCL gene encodes for the human ATP Citrate Lyase (ACL) ortholog, a metabolic enzyme that from citrate generates glucose-derived Acetyl-CoA, which fuels central biochemical reactions such as the synthesis of fatty acids, cholesterol and acetylcholine, and the acetylation of proteins and histones.	Citric Acid	126-133	ATP citrate lyase	Homo sapiens	63-80
31947614-1	2020	The Drosophila melanogaster DmATPCL gene encodes for the human ATP Citrate Lyase (ACL) ortholog, a metabolic enzyme that from citrate generates glucose-derived Acetyl-CoA, which fuels central biochemical reactions such as the synthesis of fatty acids, cholesterol and acetylcholine, and the acetylation of proteins and histones.	Citric Acid	126-133	ATP citrate lyase	Homo sapiens	82-85
31819175-2	2020	Aconitase 2 (ACO2) participates in the TCA cycle by converting citrate to isocitrate, but no evident demonstrations of its involvement in cancer metabolism have been provided so far.	Citric Acid	63-70	aconitase 2	Homo sapiens	0-11
31819175-2	2020	Aconitase 2 (ACO2) participates in the TCA cycle by converting citrate to isocitrate, but no evident demonstrations of its involvement in cancer metabolism have been provided so far.	Citric Acid	63-70	aconitase 2	Homo sapiens	13-17
31624141-8	2020	In vivo delivery of an orally active inhibitor of C5aR1 (PMX53) reversed the phenotypic changes and normalized the renal mitochondrial fatty acid profile, cardiolipin remodeling, and citric acid cycle intermediates.	Citric Acid	183-194	complement component 5a receptor 1	Mus musculus	50-55
31809960-8	2020	Six metabolites including GPC, 1-methyladenosine, maleic acid, L-pyroglutamic acid, inosine, and citrate are significantly changed (VIP >= 1 and p <= 0.05) in both serum and urine samples from patients with POP.	Citric Acid	97-104	diphosphoinositol pentakisphosphate kinase 1	Homo sapiens	132-140
31873304-5	2020	The structure of a catalytic mutant of ACLY in the presence of ATP, citrate and CoA substrates reveals a phospho-citryl-CoA intermediate in the ASH domain.	Citric Acid	68-75	ATP citrate lyase	Homo sapiens	39-43
31634706-7	2020	Meanwhile, the inhibition effects of LMWOAs on Cd2+ transport in the following order of citric acid > tartaric acid > acetic acid, which was also in agreement with the decreasing complex stability constants between Cd2+ and LMWOAs.	Citric Acid	88-99	CD2 molecule	Homo sapiens	47-50
31499095-1	2020	ATP citrate lyase (ACLY) is an important enzyme linking carbohydrate to lipid metabolism by generating acetyl-CoA from citrate for fatty acid and cholesterol biosynthesis.	Citric Acid	4-11	ATP citrate lyase	Homo sapiens	19-23
31634706-7	2020	Meanwhile, the inhibition effects of LMWOAs on Cd2+ transport in the following order of citric acid > tartaric acid > acetic acid, which was also in agreement with the decreasing complex stability constants between Cd2+ and LMWOAs.	Citric Acid	88-99	CD2 molecule	Homo sapiens	215-218
31634706-9	2020	Interestingly, when the LMWOA concentrations 0.5 mM, tartaric acid and citric acid still inhibited Cd2+ transport, while acetic acid slightly enhanced the Cd2+ mobility due to its weaker complexing strength.	Citric Acid	71-82	CD2 molecule	Homo sapiens	99-102
31634706-12	2020	In addition, citric acid could obviously inhibit the transport of Cd2+ under competitive transport conditions (i.e., with competing cations), which is mainly due to different complex affinities of citric acid to Pb2+ and Cd2+.	Citric Acid	13-24	CD2 molecule	Homo sapiens	66-69
31634706-12	2020	In addition, citric acid could obviously inhibit the transport of Cd2+ under competitive transport conditions (i.e., with competing cations), which is mainly due to different complex affinities of citric acid to Pb2+ and Cd2+.	Citric Acid	13-24	CD2 molecule	Homo sapiens	221-224
31634706-12	2020	In addition, citric acid could obviously inhibit the transport of Cd2+ under competitive transport conditions (i.e., with competing cations), which is mainly due to different complex affinities of citric acid to Pb2+ and Cd2+.	Citric Acid	197-208	CD2 molecule	Homo sapiens	66-69
31634706-12	2020	In addition, citric acid could obviously inhibit the transport of Cd2+ under competitive transport conditions (i.e., with competing cations), which is mainly due to different complex affinities of citric acid to Pb2+ and Cd2+.	Citric Acid	197-208	CD2 molecule	Homo sapiens	221-224
31842972-6	2019	This is mediated via alterations in the levels and activities of the cellular nutrient sensors 5" adenosine monophosphate-activated protein kinase (AMPK) and mammalian target of rapamycin complex 1 (mTORC1), intracellular accumulation of metabolic intermediates such as succinate and citrate, and increases in free fatty acids (FFAs) and hyperglycaemia-induced advanced glycation end-products (AGEs) that bind to receptors on the macrophage surface.	Citric Acid	284-291	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	98-146
31812361-7	2020	RESULTS: The highest transforming growth factor beta 1 release was observed after citric acid treatment followed by phosphoric acid; there was no significant difference between them, but compared with EDTA and 1% IP6, there were significant differences observed.	Citric Acid	82-93	transforming growth factor beta 1	Homo sapiens	21-54
31842972-6	2019	This is mediated via alterations in the levels and activities of the cellular nutrient sensors 5" adenosine monophosphate-activated protein kinase (AMPK) and mammalian target of rapamycin complex 1 (mTORC1), intracellular accumulation of metabolic intermediates such as succinate and citrate, and increases in free fatty acids (FFAs) and hyperglycaemia-induced advanced glycation end-products (AGEs) that bind to receptors on the macrophage surface.	Citric Acid	284-291	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	148-152
31842972-6	2019	This is mediated via alterations in the levels and activities of the cellular nutrient sensors 5" adenosine monophosphate-activated protein kinase (AMPK) and mammalian target of rapamycin complex 1 (mTORC1), intracellular accumulation of metabolic intermediates such as succinate and citrate, and increases in free fatty acids (FFAs) and hyperglycaemia-induced advanced glycation end-products (AGEs) that bind to receptors on the macrophage surface.	Citric Acid	284-291	CREB regulated transcription coactivator 1	Mus musculus	199-205
31745774-9	2019	Excess citric acid also slightly increased the LC50 by 1.3- to 2.0-fold, basic movements by 1.0- to 1.5-fold, decreased the ROS content by 2.4- to 2.1-fold, the MDA content by 4- to 2-fold, the SOD activity by 9- to 3-fold, the GPx activity by 4.0- to 3.0-fold, and the mRNA expression levels of GPxs by 3.2- to 1.8-fold after metals treatment.	Citric Acid	7-18	gpx-8	Caenorhabditis elegans	228-231
31449765-1	2019	Ferric citrate liposome (FAC-Lip) with good sustained-released property was prepared by the rotary-evaporated film-ultrasonic method, and characterized by TEM, DLS, zeta potential and encapsulation efficiency (EE%).	Citric Acid	7-14	SMG1 nonsense mediated mRNA decay associated PI3K related kinase	Homo sapiens	29-32
31745774-11	2019	This study not only provides information to further understand the effects of heavy metal exposure on ROS, MDA, GPx, SOD, and citric acid in worms but also indicates that supplemental citric acid can protect animals from heavy metal stress and has broad application prospects in decreasing oxidative damage caused by heavy metals.	Citric Acid	184-195	gpx-8	Caenorhabditis elegans	112-115
31179539-11	2019	The calcium and citrate contents in Swedish milk have changed over time, whereby calcium content has increased and citrate content has decreased.	Citric Acid	16-23	Weaning weight-maternal milk	Bos taurus	44-48
32082382-9	2019	Chondrogenesis is enhanced by EDTA-PRP and osteogenesis by citrate PRP, whereas hyperacute serum enhances both differentiations comparably.	Citric Acid	59-66	prion protein	Homo sapiens	67-70
31179539-11	2019	The calcium and citrate contents in Swedish milk have changed over time, whereby calcium content has increased and citrate content has decreased.	Citric Acid	115-122	Weaning weight-maternal milk	Bos taurus	44-48
31660563-5	2019	Finally, this low-triggering-potential ECL system was used to construct sandwiched immunosensors to detect carcinoembryonic antigen (CEA) with the potential range from 0 to -0.8 V. In this immunosensor, PDI-CH3 and gold nanoparticles (AuNPs) reduced by citrate were grafted onto graphite oxide (GO) to label secondary antibodies (Ab2).	Citric Acid	253-260	CEA cell adhesion molecule 3	Homo sapiens	107-131
31444411-6	2019	Metabolomic profiling reveals that GLDC knockdown disrupts purine and central carbon metabolism and reduces citrate production, leading to a decrease in the steady-state levels of cholesterol and fatty acids.	Citric Acid	108-115	glycine decarboxylase	Homo sapiens	35-39
31209480-7	2019	Compared with Egret-Burke, wheat line Egret-Burke TaMATE1B with citrate efflux had lower inorganic N, microbial biomass C (16 %) and N (30 %) in the rhizosphere but greater RPE (18 %), shoot biomass (12 %) and root-derived CO2-C (low P 36 %, high P 13 %).	Citric Acid	64-71	LOC101664696	Triticum aestivum	50-58
31209480-8	2019	Egret-Burke TaMATE1B also had higher concentrations of water-extractable P, Fe and Al in the rhizosphere, indicating the release of mineral-protected C. In addition, citrate ligand facilitated Fe and Al release from soil, with their concentrations rising with increasing ligand concentration and incubation time.	Citric Acid	166-173	LOC101664696	Triticum aestivum	12-20
31660563-5	2019	Finally, this low-triggering-potential ECL system was used to construct sandwiched immunosensors to detect carcinoembryonic antigen (CEA) with the potential range from 0 to -0.8 V. In this immunosensor, PDI-CH3 and gold nanoparticles (AuNPs) reduced by citrate were grafted onto graphite oxide (GO) to label secondary antibodies (Ab2).	Citric Acid	253-260	CEA cell adhesion molecule 3	Homo sapiens	133-136
31717433-7	2019	This so-called aerobic glycolysis is known as the "Warburg Effect" and serves to provide more anabolic metabolites upstream of the citric acid cycle, such as amino acids, pentoses and NADPH for cancer cell growth.	Citric Acid	131-142	2,4-dienoyl-CoA reductase 1	Homo sapiens	184-189
31650481-5	2019	The Raptor het ameliorated both TAC- and Galphaq overexpression-induced heart failure and the associated proteomic remodeling, especially those pathways involved in mitochondrial function, citric acid cycle, and ubiquitination.	Citric Acid	189-200	regulatory associated protein of MTOR, complex 1	Mus musculus	4-10
31650481-5	2019	The Raptor het ameliorated both TAC- and Galphaq overexpression-induced heart failure and the associated proteomic remodeling, especially those pathways involved in mitochondrial function, citric acid cycle, and ubiquitination.	Citric Acid	189-200	guanine nucleotide binding protein, alpha q polypeptide	Mus musculus	32-48
31763571-4	2019	Transmission electron microscopy, Fourier transform infrared spectroscopy, Thermogravimetric analysis, XRD, and anti-CD34 immunofluorescence suggested that anti-CD34 and citric acid were successfully modified onto Fe3O4, and Prussian blue staining demonstrated the selectivity of the as-prepared nanoparticles for EPCs.	Citric Acid	170-181	CD34 molecule	Homo sapiens	117-121
31350362-6	2019	On the other hand, elevated secretion of malate and citrate in vha-a2 vha-a3 root exudates appeared to be independent of OAs metabolism and tolerance of phosphate starvation but was likely related to impaired vacuolar sequestration.	Citric Acid	52-59	vacuolar proton ATPase A2	Arabidopsis thaliana	63-69
31808398-10	2019	CONCLUSION: Measurement of [CITRATE] by means of 1HNMRS is superior to PSA for early detection of csPCa in men with elevated PSA.	Citric Acid	28-35	kallikrein related peptidase 3	Homo sapiens	125-128
31543453-9	2019	Moreover, gustatory nerve responses in Otop1-KO mice were severely and selectively attenuated for acidic stimuli, including citric acid and HCl.	Citric Acid	124-135	otopetrin 1	Mus musculus	39-44
31675964-10	2019	We investigated ATP citrate lyase (ACLY) because it cleaves citrate into oxaloacetate and acetyl CoA.	Citric Acid	20-27	ATP citrate lyase	Mus musculus	35-39
31623336-3	2019	In the present study, we explored the effect of different ratios of citric acid (CA) and EDTA (CA/EDTA), which are used as stabilizers during synthesis of CeNPs, on the antioxidant enzyme-mimetic and biological activity of the CeNPs.	Citric Acid	68-79	centromere protein S	Mus musculus	155-160
31350362-6	2019	On the other hand, elevated secretion of malate and citrate in vha-a2 vha-a3 root exudates appeared to be independent of OAs metabolism and tolerance of phosphate starvation but was likely related to impaired vacuolar sequestration.	Citric Acid	52-59	vacuolar proton ATPase A3	Arabidopsis thaliana	70-76
31397148-6	2019	NTI and BNTX-type DOR inverse agonists SYK-623 and SYK-723 (12c) showed dose-dependent antitussive effects in a mouse cough model induced by citric acid exposure.	Citric Acid	141-152	opioid receptor, delta 1	Mus musculus	18-21
31493918-8	2019	Compared to the I/R group, the I/R-citric acid group had higher expression of catalase, superoxide dismutase, antioxidants, and nitric oxide, and lower expression of aspartate aminotransferase and alanine aminotransferase.	Citric Acid	35-46	catalase	Rattus norvegicus	78-86
31493918-8	2019	Compared to the I/R group, the I/R-citric acid group had higher expression of catalase, superoxide dismutase, antioxidants, and nitric oxide, and lower expression of aspartate aminotransferase and alanine aminotransferase.	Citric Acid	35-46	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	166-192
30896511-2	2019	The purpose of this study was to test cranial bone healing in a surgical defect model utilizing bone morphogenetic protein-9 (BMP-9) transduced immortalized murine adipocyte (iMAD) progenitor cells in a citrate-based, phase-changing, poly(polyethylene glycol citrate-co-N-isopropylacrylamide) (PPCN)-gelatin scaffold.	Citric Acid	203-211	growth differentiation factor 2	Mus musculus	96-124
31506465-4	2019	Ptch1+/-/ODCt/C57BL/6 mice show an altered metabolic landscape in the phenotypically normal skin, including restricted glucose availability, restricted ribose/deoxyribose flow and NADPH production, an accumulation of alpha-ketoglutarate, aconitate, and citrate that is associated with reversal of the tricarboxylic acid cycle, coupled with increased ketogenic/lipogenic activity via acetyl-CoA, 3-hydroybutyrate, and cholesterol metabolites.	Citric Acid	253-260	patched 1	Mus musculus	0-5
30896511-2	2019	The purpose of this study was to test cranial bone healing in a surgical defect model utilizing bone morphogenetic protein-9 (BMP-9) transduced immortalized murine adipocyte (iMAD) progenitor cells in a citrate-based, phase-changing, poly(polyethylene glycol citrate-co-N-isopropylacrylamide) (PPCN)-gelatin scaffold.	Citric Acid	203-211	growth differentiation factor 2	Mus musculus	126-131
31564968-2	2019	Preclinical studies have demonstrated a mutated enzyme in the citric acid cycle, isocitrate dehydrogenase (IDH), leads to the production of an oncogenic metabolite R-2-hydroxy-glutarate (R-2-HG).	Citric Acid	62-73	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	81-105
31564968-2	2019	Preclinical studies have demonstrated a mutated enzyme in the citric acid cycle, isocitrate dehydrogenase (IDH), leads to the production of an oncogenic metabolite R-2-hydroxy-glutarate (R-2-HG).	Citric Acid	62-73	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	107-110
31474035-14	2019	At PTH 24, the serum creatinine, urea nitrogen, and cystatin C of patients in citric acid group were significantly lower than those in heparin group (t=7.778, 9.776, 5.117, P&lt;0.01).	Citric Acid	78-89	parathyroid hormone	Homo sapiens	3-6
31474035-14	2019	At PTH 24, the serum creatinine, urea nitrogen, and cystatin C of patients in citric acid group were significantly lower than those in heparin group (t=7.778, 9.776, 5.117, P&lt;0.01).	Citric Acid	78-89	cystatin C	Homo sapiens	52-62
31474035-16	2019	At PTH 24, the serum procalcitonin and C-reactive protein of patients in citric acid group were significantly lower than those in heparin group (t=2.635, 2.297, P&lt;0.05).	Citric Acid	73-84	parathyroid hormone	Homo sapiens	3-6
31474035-16	2019	At PTH 24, the serum procalcitonin and C-reactive protein of patients in citric acid group were significantly lower than those in heparin group (t=2.635, 2.297, P&lt;0.05).	Citric Acid	73-84	C-reactive protein	Homo sapiens	39-57
31474035-18	2019	At PTH 24, the neutrophil, leukocyte count, blood sugar, AST, and ALT of patients in citric acid group were significantly lower than those in heparin group (t=2.054, 3.314, 7.185, 2.151, 3.013, P&lt;0.05 or P&lt;0.01).	Citric Acid	85-96	parathyroid hormone	Homo sapiens	3-6
31474035-18	2019	At PTH 24, the neutrophil, leukocyte count, blood sugar, AST, and ALT of patients in citric acid group were significantly lower than those in heparin group (t=2.054, 3.314, 7.185, 2.151, 3.013, P&lt;0.05 or P&lt;0.01).	Citric Acid	85-96	solute carrier family 17 member 5	Homo sapiens	57-60
31474035-20	2019	At PTH 24, the heart rate, body temperature, and mean arterial pressure of patients in citric acid group were significantly lower than those in heparin group (t=2.307, 4.498, 2.056, P&lt;0.05 or P&lt;0.01).	Citric Acid	87-98	parathyroid hormone	Homo sapiens	3-6
31188034-2	2019	Both metabolic acidosis and hypokalemia decrease citrate excretion and increase expression of Na+-dicarboxylate cotransporter 1 (NaDC1; SLC13A2), the primary protein involved in citrate reabsorption.	Citric Acid	178-185	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2	Mus musculus	94-127
31474035-12	2019	At PTH 24, the platelet count of patients in citric acid group was significantly higher than that in heparin group (t=10.947, P&lt;0.01), and APTT and PT of patients in citric acid group were significantly shorter than those in heparin group (t=7.069, 9.142, P&lt;0.01).	Citric Acid	45-56	parathyroid hormone	Homo sapiens	3-6
31411782-1	2019	ATP-citrate lyase (ACLY) catalyzes production of acetyl-CoA and oxaloacetate from CoA and citrate using ATP.	Citric Acid	4-11	ATP citrate lyase	Homo sapiens	19-23
31188034-2	2019	Both metabolic acidosis and hypokalemia decrease citrate excretion and increase expression of Na+-dicarboxylate cotransporter 1 (NaDC1; SLC13A2), the primary protein involved in citrate reabsorption.	Citric Acid	178-185	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2	Mus musculus	129-134
31188034-2	2019	Both metabolic acidosis and hypokalemia decrease citrate excretion and increase expression of Na+-dicarboxylate cotransporter 1 (NaDC1; SLC13A2), the primary protein involved in citrate reabsorption.	Citric Acid	178-185	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2	Mus musculus	136-143
31150280-2	2019	Here we showed that ATP-citrate lyase (ACL), an enzyme converting citrate to acetyl-CoA, is highly induced in the kidney of overweight or obese patients with CKD and ob/ob BTBR mice.	Citric Acid	24-31	ATP citrate lyase	Homo sapiens	39-42
31555705-0	2019	The effects of citrate dialysate in hemodialysis on polymorphonuclear elastase interaction with tissue factor and its inhibitor.	Citric Acid	15-22	elastase, neutrophil expressed	Homo sapiens	52-78
31555705-0	2019	The effects of citrate dialysate in hemodialysis on polymorphonuclear elastase interaction with tissue factor and its inhibitor.	Citric Acid	15-22	coagulation factor III, tissue factor	Homo sapiens	96-109
31357597-5	2019	The therapeutic intervention by citrate-based coupled plasma filtration adsorption (CPFA) significantly reduced LBP, TGF-beta, and endothelin-1 (ET-1) serum levels, and furthermore preserved PDGFRbeta and decreased alpha-SMA expression in renal biopsies.	Citric Acid	32-39	LBP	Sus scrofa	112-115
31155267-0	2019	Natural variations of citrate and calcium in milk and their effects on milk processing properties.	Citric Acid	22-29	Weaning weight-maternal milk	Bos taurus	45-49
31155267-0	2019	Natural variations of citrate and calcium in milk and their effects on milk processing properties.	Citric Acid	22-29	Weaning weight-maternal milk	Bos taurus	71-75
31155267-2	2019	In this study, we focused on natural variations in milk citrate and its interplay with calcium distribution in milk, in relation to processing properties.	Citric Acid	56-63	Weaning weight-maternal milk	Bos taurus	51-55
31155267-6	2019	No significant change in citrate content was observed during the sampling period, which suggests that mechanisms other than feeding affect citrate levels in milk.	Citric Acid	139-146	Weaning weight-maternal milk	Bos taurus	157-161
31098816-6	2019	The objective of this study was to compare the stability of both aPTT and anti-Xa in citrate and CTAD samples, and to determine the effect of delayed centrifugation on both aPTT, anti-Xa results, and PF4 release in citrate samples only.	Citric Acid	215-222	platelet factor 4	Homo sapiens	200-203
31068457-1	2019	Mutations of the isocitrate dehydrogenase genes IDH1 and IDH2, key enzymes involved in citrate metabolism, are important oncogenic events in several cancer types, including in 1%-3% of all prostate cancer cases.	Citric Acid	20-27	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	48-52
31068457-1	2019	Mutations of the isocitrate dehydrogenase genes IDH1 and IDH2, key enzymes involved in citrate metabolism, are important oncogenic events in several cancer types, including in 1%-3% of all prostate cancer cases.	Citric Acid	20-27	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	57-61
31376963-10	2019	Leaching with 1 M citrate, 0.2 M N2H4, at pH = 5, using sodium hydroxide (NaOH) at solid:liquid (S:L) ratio of 20 g L-1, yielded a remarkably high In recovery of 98.9% after 16.6 h.	Citric Acid	18-25	L1 cell adhesion molecule	Homo sapiens	116-119
31555705-6	2019	Results: Compared with the control group, the plasma TFPI levels of the LMWH group and the citrate group were significantly higher (P=0.000, P=0.002, respectively) under baseline conditions as well as the plasma PMNE levels (P=0.001, P=0.02, respectively), whereas TF showed no difference (P=0.186).	Citric Acid	91-98	tissue factor pathway inhibitor	Homo sapiens	53-57
31555705-6	2019	Results: Compared with the control group, the plasma TFPI levels of the LMWH group and the citrate group were significantly higher (P=0.000, P=0.002, respectively) under baseline conditions as well as the plasma PMNE levels (P=0.001, P=0.02, respectively), whereas TF showed no difference (P=0.186).	Citric Acid	91-98	elastase, neutrophil expressed	Homo sapiens	212-216
31555705-6	2019	Results: Compared with the control group, the plasma TFPI levels of the LMWH group and the citrate group were significantly higher (P=0.000, P=0.002, respectively) under baseline conditions as well as the plasma PMNE levels (P=0.001, P=0.02, respectively), whereas TF showed no difference (P=0.186).	Citric Acid	91-98	coagulation factor III, tissue factor	Homo sapiens	53-55
31555705-7	2019	During HD with citrate, plasma TFPI decreased slightly (P=0.012) and PMNE increased significantly (P=0.008) at 1 h. The plasma TFPI levels of the citrate group correlate with PMNE at 2 and 5 h (P=0.001, P=0.008, respectively).	Citric Acid	15-22	tissue factor pathway inhibitor	Homo sapiens	31-35
31555705-7	2019	During HD with citrate, plasma TFPI decreased slightly (P=0.012) and PMNE increased significantly (P=0.008) at 1 h. The plasma TFPI levels of the citrate group correlate with PMNE at 2 and 5 h (P=0.001, P=0.008, respectively).	Citric Acid	15-22	elastase, neutrophil expressed	Homo sapiens	69-73
31555705-7	2019	During HD with citrate, plasma TFPI decreased slightly (P=0.012) and PMNE increased significantly (P=0.008) at 1 h. The plasma TFPI levels of the citrate group correlate with PMNE at 2 and 5 h (P=0.001, P=0.008, respectively).	Citric Acid	15-22	tissue factor pathway inhibitor	Homo sapiens	127-131
31555705-7	2019	During HD with citrate, plasma TFPI decreased slightly (P=0.012) and PMNE increased significantly (P=0.008) at 1 h. The plasma TFPI levels of the citrate group correlate with PMNE at 2 and 5 h (P=0.001, P=0.008, respectively).	Citric Acid	15-22	elastase, neutrophil expressed	Homo sapiens	175-179
31555705-7	2019	During HD with citrate, plasma TFPI decreased slightly (P=0.012) and PMNE increased significantly (P=0.008) at 1 h. The plasma TFPI levels of the citrate group correlate with PMNE at 2 and 5 h (P=0.001, P=0.008, respectively).	Citric Acid	146-153	tissue factor pathway inhibitor	Homo sapiens	31-35
31555705-7	2019	During HD with citrate, plasma TFPI decreased slightly (P=0.012) and PMNE increased significantly (P=0.008) at 1 h. The plasma TFPI levels of the citrate group correlate with PMNE at 2 and 5 h (P=0.001, P=0.008, respectively).	Citric Acid	146-153	elastase, neutrophil expressed	Homo sapiens	69-73
31555705-7	2019	During HD with citrate, plasma TFPI decreased slightly (P=0.012) and PMNE increased significantly (P=0.008) at 1 h. The plasma TFPI levels of the citrate group correlate with PMNE at 2 and 5 h (P=0.001, P=0.008, respectively).	Citric Acid	146-153	tissue factor pathway inhibitor	Homo sapiens	127-131
31555705-7	2019	During HD with citrate, plasma TFPI decreased slightly (P=0.012) and PMNE increased significantly (P=0.008) at 1 h. The plasma TFPI levels of the citrate group correlate with PMNE at 2 and 5 h (P=0.001, P=0.008, respectively).	Citric Acid	146-153	elastase, neutrophil expressed	Homo sapiens	175-179
31555705-9	2019	TFPI and PMNE are differently regulated, but the plasma levels correlated during HD in the citrate group.	Citric Acid	91-98	tissue factor pathway inhibitor	Homo sapiens	0-4
31555705-9	2019	TFPI and PMNE are differently regulated, but the plasma levels correlated during HD in the citrate group.	Citric Acid	91-98	elastase, neutrophil expressed	Homo sapiens	9-13
31357597-5	2019	The therapeutic intervention by citrate-based coupled plasma filtration adsorption (CPFA) significantly reduced LBP, TGF-beta, and endothelin-1 (ET-1) serum levels, and furthermore preserved PDGFRbeta and decreased alpha-SMA expression in renal biopsies.	Citric Acid	32-39	transforming growth factor alpha	Sus scrofa	117-125
31357597-5	2019	The therapeutic intervention by citrate-based coupled plasma filtration adsorption (CPFA) significantly reduced LBP, TGF-beta, and endothelin-1 (ET-1) serum levels, and furthermore preserved PDGFRbeta and decreased alpha-SMA expression in renal biopsies.	Citric Acid	32-39	endothelin-1	Sus scrofa	131-143
31357597-5	2019	The therapeutic intervention by citrate-based coupled plasma filtration adsorption (CPFA) significantly reduced LBP, TGF-beta, and endothelin-1 (ET-1) serum levels, and furthermore preserved PDGFRbeta and decreased alpha-SMA expression in renal biopsies.	Citric Acid	32-39	endothelin-1	Sus scrofa	145-149
31357597-5	2019	The therapeutic intervention by citrate-based coupled plasma filtration adsorption (CPFA) significantly reduced LBP, TGF-beta, and endothelin-1 (ET-1) serum levels, and furthermore preserved PDGFRbeta and decreased alpha-SMA expression in renal biopsies.	Citric Acid	32-39	PDGFRB	Sus scrofa	191-200
31337804-0	2019	Citrate anion improves chronic dialysis efficacy, reduces systemic inflammation and prevents Chemerin-mediated microvascular injury.	Citric Acid	0-7	retinoic acid receptor responder 2	Homo sapiens	93-101
31337804-7	2019	Citrate dialysis increased HD efficacy and reduced plasma levels of CRP, fibrinogen, IL6 and chemerin.	Citric Acid	0-7	C-reactive protein	Homo sapiens	68-71
31337804-7	2019	Citrate dialysis increased HD efficacy and reduced plasma levels of CRP, fibrinogen, IL6 and chemerin.	Citric Acid	0-7	fibrinogen beta chain	Homo sapiens	73-83
31337804-7	2019	Citrate dialysis increased HD efficacy and reduced plasma levels of CRP, fibrinogen, IL6 and chemerin.	Citric Acid	0-7	interleukin 6	Homo sapiens	85-88
31337804-7	2019	Citrate dialysis increased HD efficacy and reduced plasma levels of CRP, fibrinogen, IL6 and chemerin.	Citric Acid	0-7	retinoic acid receptor responder 2	Homo sapiens	93-101
31337804-9	2019	These effects were reduced by citrate-buffered solutions and paralleled by the decrease of chemerin levels.	Citric Acid	30-37	retinoic acid receptor responder 2	Homo sapiens	91-99
31337804-11	2019	In conclusion, Switching from acetate to citrate improved dialysis efficacy and inflammatory parameters; in vitro, chemerin-induced EC and VSMC injury were decreased by using citrate as dialysis buffer.	Citric Acid	41-48	retinoic acid receptor responder 2	Homo sapiens	115-123
31337804-11	2019	In conclusion, Switching from acetate to citrate improved dialysis efficacy and inflammatory parameters; in vitro, chemerin-induced EC and VSMC injury were decreased by using citrate as dialysis buffer.	Citric Acid	175-182	retinoic acid receptor responder 2	Homo sapiens	115-123
31169845-10	2019	In conclusion, CPE containing citric acid together with various bioactive compounds may be used as a chemopreventive agent for post-therapy cancer patients.	Citric Acid	30-41	carboxypeptidase E	Homo sapiens	15-18
31015085-1	2019	In this study, CuFe2O4 nanocomposite loaded on natural sepiolite (CuFe2O4/SEP) was prepared by the citrate sol-gel method.	Citric Acid	99-106	membrane metalloendopeptidase like 1	Homo sapiens	66-77
31202812-8	2019	These miRNAs can suppress the expression of Nadc1 and Cldn14, thus enhancing urinary citrate excretion and reducing urinary calcium excretion.	Citric Acid	85-92	solute carrier family 13 member 2	Homo sapiens	44-49
31202812-8	2019	These miRNAs can suppress the expression of Nadc1 and Cldn14, thus enhancing urinary citrate excretion and reducing urinary calcium excretion.	Citric Acid	85-92	claudin 14	Homo sapiens	54-60
31308404-1	2019	The enzyme succinate dehydrogenase (SDH) functions in the citric acid cycle and loss of function predisposes to the development of phaeochromocytoma/paraganglioma (PPGL), wild type gastrointestinal stromal tumour (wtGIST) and renal cell carcinoma.	Citric Acid	58-69	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	11-34
31308404-1	2019	The enzyme succinate dehydrogenase (SDH) functions in the citric acid cycle and loss of function predisposes to the development of phaeochromocytoma/paraganglioma (PPGL), wild type gastrointestinal stromal tumour (wtGIST) and renal cell carcinoma.	Citric Acid	58-69	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	36-39
32373781-0	2019	Entry of glucose- and glutamine-derived carbons into the citric acid cycle supports early steps of HIV-1 infection in CD4 T cells.	Citric Acid	57-68	CD4 molecule	Homo sapiens	118-121
31213557-10	2019	This suggests that the dissection of the conserved Cand1-encoding gene within the genome of aspergilli was possible because it allowed the integration of a fungus-specific protein required for growth into the CandA complex in two different gene set versions, which might provide an advantage in evolution.IMPORTANCE Aspergillus species are important for biotechnological applications, like the production of citric acid or antibacterial agents.	Citric Acid	408-419	cullin associated and neddylation dissociated 1	Homo sapiens	51-56
30902655-10	2019	In a guinea pig cough model, BLU-5937 (0.3, 3 and 30 mg/kg, oral) significantly reduced, in a dose-dependent fashion, the histamine-induced enhancement in the number of citric acid-induced coughs.	Citric Acid	169-180	zinc finger MYND-type containing 10	Homo sapiens	29-32
30892081-8	2019	ACC activation with citrate replicates these CF phenotypes in WT cells further supporting the role of AMPK signaling through ACC as a key mediator in CF cell signaling.	Citric Acid	20-27	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	102-106
30903842-3	2019	Therefore, the aggregation and dissolution of nAg and nZnO pretreated with citric acid (CA), tartaric acid (TA) and fulvic acid (FA) in simulated lung biological fluids (artificial lysosomal fluid (ALF) and Gamble Solution) were investigated.	Citric Acid	75-86	NBAS subunit of NRZ tethering complex	Homo sapiens	46-49
31006963-9	2019	No ADAMTS13 activity decrease was seen in heparinized plasma, but the addition of citrate again caused ADAMTS13 instability at 37 C. Scavenging of citrate by the addition of Ca2+ or Zn2+ prior to but not postincubation prevented the activity decrease of the enzyme.	Citric Acid	82-89	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	103-111
31006963-9	2019	No ADAMTS13 activity decrease was seen in heparinized plasma, but the addition of citrate again caused ADAMTS13 instability at 37 C. Scavenging of citrate by the addition of Ca2+ or Zn2+ prior to but not postincubation prevented the activity decrease of the enzyme.	Citric Acid	147-154	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	103-111
30902655-11	2019	BLU-5937 (3 and 30 mg/kg, oral) was also shown to reduce significantly and dose-dependently the ATP-induced enhancement of citric acid-induced coughs in the guinea pig.	Citric Acid	123-134	zinc finger MYND-type containing 10	Homo sapiens	0-3
30794332-8	2019	RESULTS: Study 1 identified that inclusion of citrate in PAS resulted in a dose-dependent increase in glucose utilization, lactate formation, P-selectin expression, phosphatidylserine (PS) exposure, and reactive oxygen species (ROS) formation.	Citric Acid	46-53	selectin P	Homo sapiens	142-152
30794332-9	2019	Study 2 showed similar results in which platelets stored in citrate-free PAS-III benefited through better maintenance of glucose utilization with less lactate production, P-selectin expression, PS exposure, and ROS formation compared to citrate-containing PAS-III.	Citric Acid	60-67	mucin 15, cell surface associated	Homo sapiens	73-80
30794332-9	2019	Study 2 showed similar results in which platelets stored in citrate-free PAS-III benefited through better maintenance of glucose utilization with less lactate production, P-selectin expression, PS exposure, and ROS formation compared to citrate-containing PAS-III.	Citric Acid	60-67	selectin P	Homo sapiens	171-181
30794332-10	2019	Platelets stored in citrate-free PAS-III had aggregation responses that were at least 10% greater than those platelets stored in PAS-III.	Citric Acid	20-27	mucin 15, cell surface associated	Homo sapiens	33-40
31141937-4	2019	Acute administration of high levels of extracellular citrate impaired cell adhesion and inhibited the proliferation of PC3 cells, but surviving cells adapted to grow in the chronic presence of 20 mM citrate.	Citric Acid	53-60	proprotein convertase subtilisin/kexin type 1	Homo sapiens	119-122
30794332-11	2019	CONCLUSION: Storage of apheresis platelets in citrate-free PAS-III improved multiple storage parameters including glucose utilization, lactate production, P-selection expression, PS exposure, and ROS formation and resulted in a modest increase in aggregation.	Citric Acid	46-53	mucin 15, cell surface associated	Homo sapiens	59-66
31141937-5	2019	Citrate-resistant PC3 cells are significantly less glycolytic than control cells.	Citric Acid	0-7	proprotein convertase subtilisin/kexin type 1	Homo sapiens	18-21
30973710-5	2019	This release occurred via synergistic citrate and ascorbate effects, which pointed to respective roles as the likely elusive Fe chelator and reductant within the Tf cycle.	Citric Acid	38-45	transferrin	Homo sapiens	162-164
31141937-6	2019	Moreover, they overexpress short-form, citrate-insensitive phosphofructokinase 1 (PFK1) together with full-length PFK1.	Citric Acid	39-46	phosphofructokinase, muscle	Homo sapiens	82-86
31141937-8	2019	In comparison with PC3 cells, citrate-resistant cells display morphological changes that involve both microtubule and microfilament organization.	Citric Acid	30-37	proprotein convertase subtilisin/kexin type 1	Homo sapiens	19-22
30790654-7	2019	The results showed that the cardiac energy metabolism (especially the citrate cycle), actin cytoskeleton organization, and cardiac muscle contraction (related to mitogen-activated protein kinase, toll-like receptor, and ErbB signalling pathway) were potential core mechanisms underlying ADRB3-KO-induced LVDD.	Citric Acid	70-77	adrenergic receptor, beta 3	Mus musculus	287-292
31191018-10	2019	Furthermore, isoform 1 of LINC00477 was determined to interact with ACO1 and suppress the conversion ability from citrate to isocitrate by ACO1.	Citric Acid	114-121	long intergenic non-protein coding RNA 477	Homo sapiens	26-35
31191018-10	2019	Furthermore, isoform 1 of LINC00477 was determined to interact with ACO1 and suppress the conversion ability from citrate to isocitrate by ACO1.	Citric Acid	114-121	aconitase 1	Homo sapiens	68-72
31191018-10	2019	Furthermore, isoform 1 of LINC00477 was determined to interact with ACO1 and suppress the conversion ability from citrate to isocitrate by ACO1.	Citric Acid	114-121	aconitase 1	Homo sapiens	139-143
30992036-4	2019	RESULTS: On multivariate logistic regression analysis adjusted for age and gender, predictors of high H3Cit (&gt;= 7.36 ng/mL, upper quartile) were: glycated hemoglobin (HbA1c) &gt;= 7.0% and interleukin-6.	Citric Acid	102-107	interleukin 6	Homo sapiens	192-205
30784975-5	2019	Comparatively, the highest Cu removal (92.5%) and the second largest BDE-209 removal (85.6%) were achieved by the joint application of MCD and citric acid in anolyte during the EK-persulfate treatment.	Citric Acid	143-154	homeobox D13	Homo sapiens	69-72
30972978-3	2019	In prostate cancer, cells undergo metabolic transformation from zinc-accumulating, citrate-producing cells to citrate-oxidizing malignant cells with lower zinc levels and higher mitochondrial aconitase (ACO2) activity.	Citric Acid	110-117	aconitase 2	Homo sapiens	178-201
30972978-3	2019	In prostate cancer, cells undergo metabolic transformation from zinc-accumulating, citrate-producing cells to citrate-oxidizing malignant cells with lower zinc levels and higher mitochondrial aconitase (ACO2) activity.	Citric Acid	110-117	aconitase 2	Homo sapiens	203-207
30972978-4	2019	ACO2 is a Krebs cycle enzyme that converts citrate to isocitrate and is sensitive to reactive oxygen species (ROS)-mediated damage.	Citric Acid	43-50	aconitase 2	Homo sapiens	0-4
31035650-0	2019	Citrate-Induced p85alpha-PTEN Complex Formation Causes G2/M Phase Arrest in Human Pharyngeal Squamous Carcinoma Cell Lines.	Citric Acid	0-7	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	16-24
31035650-0	2019	Citrate-Induced p85alpha-PTEN Complex Formation Causes G2/M Phase Arrest in Human Pharyngeal Squamous Carcinoma Cell Lines.	Citric Acid	0-7	phosphatase and tensin homolog	Homo sapiens	25-29
31035650-4	2019	A coimmunoprecipitation study demonstrated that citrate-induced cell cycle arrest in the G2/M phase was associated with stabilizing the formation of cyclin B1-phospho (p)-cyclin-dependent kinase 1 (CDK1) (Thr 161) complexes.	Citric Acid	48-55	cyclin B1	Homo sapiens	149-158
31035650-4	2019	A coimmunoprecipitation study demonstrated that citrate-induced cell cycle arrest in the G2/M phase was associated with stabilizing the formation of cyclin B1-phospho (p)-cyclin-dependent kinase 1 (CDK1) (Thr 161) complexes.	Citric Acid	48-55	cyclin dependent kinase 1	Homo sapiens	171-196
31035650-4	2019	A coimmunoprecipitation study demonstrated that citrate-induced cell cycle arrest in the G2/M phase was associated with stabilizing the formation of cyclin B1-phospho (p)-cyclin-dependent kinase 1 (CDK1) (Thr 161) complexes.	Citric Acid	48-55	cyclin dependent kinase 1	Homo sapiens	198-202
31035650-5	2019	The citrate-induced increased levels of cyclin B1 and G2/M phase arrest were suppressed by the caspase-3 inhibitor Ac-DEVD-CMK and caspase-3 cleavage of mutant p21 (D112N).	Citric Acid	4-11	cyclin B1	Homo sapiens	40-49
31035650-5	2019	The citrate-induced increased levels of cyclin B1 and G2/M phase arrest were suppressed by the caspase-3 inhibitor Ac-DEVD-CMK and caspase-3 cleavage of mutant p21 (D112N).	Citric Acid	4-11	caspase 3	Homo sapiens	95-104
31035650-5	2019	The citrate-induced increased levels of cyclin B1 and G2/M phase arrest were suppressed by the caspase-3 inhibitor Ac-DEVD-CMK and caspase-3 cleavage of mutant p21 (D112N).	Citric Acid	4-11	cytidine/uridine monophosphate kinase 1	Homo sapiens	123-126
31035650-5	2019	The citrate-induced increased levels of cyclin B1 and G2/M phase arrest were suppressed by the caspase-3 inhibitor Ac-DEVD-CMK and caspase-3 cleavage of mutant p21 (D112N).	Citric Acid	4-11	caspase 3	Homo sapiens	131-140
31035650-5	2019	The citrate-induced increased levels of cyclin B1 and G2/M phase arrest were suppressed by the caspase-3 inhibitor Ac-DEVD-CMK and caspase-3 cleavage of mutant p21 (D112N).	Citric Acid	4-11	H3 histone pseudogene 16	Homo sapiens	160-163
31035650-6	2019	Ectopic expression of the constitutively active form of protein kinase B (Akt1) could overcome the induction of p21 cleavage, cyclin B1-p-CDK1 (Thr 161) complexes, and G2/M phase arrest by citrate.	Citric Acid	189-196	AKT serine/threonine kinase 1	Homo sapiens	74-78
31035650-7	2019	p85alpha-phosphatase and tensin homolog deleted from chromosome 10 (PTEN) complex-mediated inactivation of Akt was required for citrate-induced G2/M phase cell cycle arrest because PTEN short hairpin RNA or a PTEN inhibitor (SF1670) blocked the suppression of Akt Ser 473 phosphorylation and the induction of cyclin B1-p-CDK1 (Thr 161) complexes and G2/M phase arrest by citrate.	Citric Acid	128-135	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	0-8
31035650-7	2019	p85alpha-phosphatase and tensin homolog deleted from chromosome 10 (PTEN) complex-mediated inactivation of Akt was required for citrate-induced G2/M phase cell cycle arrest because PTEN short hairpin RNA or a PTEN inhibitor (SF1670) blocked the suppression of Akt Ser 473 phosphorylation and the induction of cyclin B1-p-CDK1 (Thr 161) complexes and G2/M phase arrest by citrate.	Citric Acid	128-135	phosphatase and tensin homolog	Homo sapiens	68-72
31035650-7	2019	p85alpha-phosphatase and tensin homolog deleted from chromosome 10 (PTEN) complex-mediated inactivation of Akt was required for citrate-induced G2/M phase cell cycle arrest because PTEN short hairpin RNA or a PTEN inhibitor (SF1670) blocked the suppression of Akt Ser 473 phosphorylation and the induction of cyclin B1-p-CDK1 (Thr 161) complexes and G2/M phase arrest by citrate.	Citric Acid	128-135	AKT serine/threonine kinase 1	Homo sapiens	107-110
31035650-7	2019	p85alpha-phosphatase and tensin homolog deleted from chromosome 10 (PTEN) complex-mediated inactivation of Akt was required for citrate-induced G2/M phase cell cycle arrest because PTEN short hairpin RNA or a PTEN inhibitor (SF1670) blocked the suppression of Akt Ser 473 phosphorylation and the induction of cyclin B1-p-CDK1 (Thr 161) complexes and G2/M phase arrest by citrate.	Citric Acid	128-135	phosphatase and tensin homolog	Homo sapiens	181-185
31035650-7	2019	p85alpha-phosphatase and tensin homolog deleted from chromosome 10 (PTEN) complex-mediated inactivation of Akt was required for citrate-induced G2/M phase cell cycle arrest because PTEN short hairpin RNA or a PTEN inhibitor (SF1670) blocked the suppression of Akt Ser 473 phosphorylation and the induction of cyclin B1-p-CDK1 (Thr 161) complexes and G2/M phase arrest by citrate.	Citric Acid	128-135	phosphatase and tensin homolog	Homo sapiens	181-185
31035650-7	2019	p85alpha-phosphatase and tensin homolog deleted from chromosome 10 (PTEN) complex-mediated inactivation of Akt was required for citrate-induced G2/M phase cell cycle arrest because PTEN short hairpin RNA or a PTEN inhibitor (SF1670) blocked the suppression of Akt Ser 473 phosphorylation and the induction of cyclin B1-p-CDK1 (Thr 161) complexes and G2/M phase arrest by citrate.	Citric Acid	128-135	AKT serine/threonine kinase 1	Homo sapiens	260-263
31035650-7	2019	p85alpha-phosphatase and tensin homolog deleted from chromosome 10 (PTEN) complex-mediated inactivation of Akt was required for citrate-induced G2/M phase cell cycle arrest because PTEN short hairpin RNA or a PTEN inhibitor (SF1670) blocked the suppression of Akt Ser 473 phosphorylation and the induction of cyclin B1-p-CDK1 (Thr 161) complexes and G2/M phase arrest by citrate.	Citric Acid	128-135	cyclin B1	Homo sapiens	309-318
31035650-7	2019	p85alpha-phosphatase and tensin homolog deleted from chromosome 10 (PTEN) complex-mediated inactivation of Akt was required for citrate-induced G2/M phase cell cycle arrest because PTEN short hairpin RNA or a PTEN inhibitor (SF1670) blocked the suppression of Akt Ser 473 phosphorylation and the induction of cyclin B1-p-CDK1 (Thr 161) complexes and G2/M phase arrest by citrate.	Citric Acid	128-135	cyclin dependent kinase 1	Homo sapiens	321-325
31035650-7	2019	p85alpha-phosphatase and tensin homolog deleted from chromosome 10 (PTEN) complex-mediated inactivation of Akt was required for citrate-induced G2/M phase cell cycle arrest because PTEN short hairpin RNA or a PTEN inhibitor (SF1670) blocked the suppression of Akt Ser 473 phosphorylation and the induction of cyclin B1-p-CDK1 (Thr 161) complexes and G2/M phase arrest by citrate.	Citric Acid	371-378	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	0-8
31035650-7	2019	p85alpha-phosphatase and tensin homolog deleted from chromosome 10 (PTEN) complex-mediated inactivation of Akt was required for citrate-induced G2/M phase cell cycle arrest because PTEN short hairpin RNA or a PTEN inhibitor (SF1670) blocked the suppression of Akt Ser 473 phosphorylation and the induction of cyclin B1-p-CDK1 (Thr 161) complexes and G2/M phase arrest by citrate.	Citric Acid	371-378	phosphatase and tensin homolog	Homo sapiens	68-72
31035650-7	2019	p85alpha-phosphatase and tensin homolog deleted from chromosome 10 (PTEN) complex-mediated inactivation of Akt was required for citrate-induced G2/M phase cell cycle arrest because PTEN short hairpin RNA or a PTEN inhibitor (SF1670) blocked the suppression of Akt Ser 473 phosphorylation and the induction of cyclin B1-p-CDK1 (Thr 161) complexes and G2/M phase arrest by citrate.	Citric Acid	371-378	AKT serine/threonine kinase 1	Homo sapiens	107-110
31035650-8	2019	In conclusion, citrate induces G2/M phase arrest in PSC cells by inducing the formation of p85alpha-PTEN complexes to attenuate Akt-mediated signaling, thereby causing the formation of cyclin B1-p-CDK1 (Thr 161) complexes.	Citric Acid	15-22	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	91-99
31035650-8	2019	In conclusion, citrate induces G2/M phase arrest in PSC cells by inducing the formation of p85alpha-PTEN complexes to attenuate Akt-mediated signaling, thereby causing the formation of cyclin B1-p-CDK1 (Thr 161) complexes.	Citric Acid	15-22	phosphatase and tensin homolog	Homo sapiens	100-104
31035650-8	2019	In conclusion, citrate induces G2/M phase arrest in PSC cells by inducing the formation of p85alpha-PTEN complexes to attenuate Akt-mediated signaling, thereby causing the formation of cyclin B1-p-CDK1 (Thr 161) complexes.	Citric Acid	15-22	AKT serine/threonine kinase 1	Homo sapiens	128-131
31035650-8	2019	In conclusion, citrate induces G2/M phase arrest in PSC cells by inducing the formation of p85alpha-PTEN complexes to attenuate Akt-mediated signaling, thereby causing the formation of cyclin B1-p-CDK1 (Thr 161) complexes.	Citric Acid	15-22	cyclin B1	Homo sapiens	185-194
31035650-8	2019	In conclusion, citrate induces G2/M phase arrest in PSC cells by inducing the formation of p85alpha-PTEN complexes to attenuate Akt-mediated signaling, thereby causing the formation of cyclin B1-p-CDK1 (Thr 161) complexes.	Citric Acid	15-22	cyclin dependent kinase 1	Homo sapiens	197-201
31058131-5	2019	Anti-VEGF antibody was covalently immobilized on the surface of the polymer films through attachment to citrate-functionalized Au NPs, and the resulting composites were used to detect VEGF-165 by electrochemical impedance spectroscopy (EIS).	Citric Acid	104-111	vascular endothelial growth factor A	Homo sapiens	5-9
30589099-1	2019	The succinate dehydrogenase (SDH) enzyme complex functions as a key enzyme coupling the oxidation of succinate to fumarate in the citric acid cycle.	Citric Acid	130-141	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	4-27
30912776-2	2019	In this article, we have studied the interaction of citrate-capped GNPs of 16, 28, 41, and 69 nm sizes with Lyz by the non-destructive label-free second harmonic light scattering (SHLS) technique at physiological pH in phosphate buffer.	Citric Acid	52-59	lysozyme	Homo sapiens	108-111
31019471-1	2019	The Citrate Lyase (ACL) is the main cytosolic enzyme that converts the citrate exported from mitochondria by the SLC25A1 carrier in Acetyl Coenzyme A (acetyl-CoA) and oxaloacetate.	Citric Acid	71-78	solute carrier family 25 member 1	Homo sapiens	113-120
31019471-7	2019	Interestingly, depletion of ATPCL drastically increased the frequency of chromosome breaks (CBs) associated to mutations in scheggia, which encodes the ortholog of the mitochondrial citrate carrier SLC25A1 that is also required for chromosome integrity and histone acetylation.	Citric Acid	182-189	ATP citrate lyase	Homo sapiens	28-33
31019471-7	2019	Interestingly, depletion of ATPCL drastically increased the frequency of chromosome breaks (CBs) associated to mutations in scheggia, which encodes the ortholog of the mitochondrial citrate carrier SLC25A1 that is also required for chromosome integrity and histone acetylation.	Citric Acid	182-189	solute carrier family 25 member 1	Homo sapiens	198-205
31019471-8	2019	Our results indicate that ATPCL has a dispensable role in histone acetylation and prevents massive chromosome fragmentation when citrate efflux is altered.	Citric Acid	129-136	ATP citrate lyase	Homo sapiens	26-31
30589099-1	2019	The succinate dehydrogenase (SDH) enzyme complex functions as a key enzyme coupling the oxidation of succinate to fumarate in the citric acid cycle.	Citric Acid	130-141	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	29-32
32308292-9	2019	Citric acid had reduced the hardness of CFM and had caused surface roughness on Sure fill SDR and Tetric Evo Ceram.	Citric Acid	0-11	caveolae associated protein 2	Homo sapiens	90-93
31015764-7	2019	The mechanisms involved in the abovementioned phenomena were that TNF-alpha knockout inhibited the citrate cycle and increased starch, sucrose, amino sugar and nucleotide sugar metabolism.	Citric Acid	99-106	tumor necrosis factor	Homo sapiens	66-75
30944472-1	2019	ATP-citrate lyase (ACLY) is a central metabolic enzyme and catalyses the ATP-dependent conversion of citrate and coenzyme A (CoA) to oxaloacetate and acetyl-CoA1-5.	Citric Acid	4-11	ATP citrate lyase	Homo sapiens	19-23
30944472-1	2019	ATP-citrate lyase (ACLY) is a central metabolic enzyme and catalyses the ATP-dependent conversion of citrate and coenzyme A (CoA) to oxaloacetate and acetyl-CoA1-5.	Citric Acid	4-11	cytochrome c oxidase assembly factor 1	Homo sapiens	157-161
30944476-1	2019	Across different kingdoms of life, ATP citrate lyase (ACLY, also known as ACL) catalyses the ATP-dependent and coenzyme A (CoA)-dependent conversion of citrate, a metabolic product of the Krebs cycle, to oxaloacetate and the high-energy biosynthetic precursor acetyl-CoA1.	Citric Acid	39-46	ATP citrate lyase	Homo sapiens	54-58
30944476-1	2019	Across different kingdoms of life, ATP citrate lyase (ACLY, also known as ACL) catalyses the ATP-dependent and coenzyme A (CoA)-dependent conversion of citrate, a metabolic product of the Krebs cycle, to oxaloacetate and the high-energy biosynthetic precursor acetyl-CoA1.	Citric Acid	39-46	cytochrome c oxidase assembly factor 1	Homo sapiens	267-271
30935029-3	2019	MMP-9 expression was assessed in response to ethylenediaminetetraacetic acid, citrate, and high-/low-molecular-weight heparin (HMWH, LMWH) in co-culture experiments using THP-1, Jurkat, and HT cells (representing monocytes, T, and B cells).	Citric Acid	78-85	matrix metallopeptidase 9	Homo sapiens	0-5
30850587-6	2019	The underlying mechanism mainly involves citrate-stimulated activation of the AKT/ERK/MMP2/9 signaling axis.	Citric Acid	41-48	thymoma viral proto-oncogene 1	Mus musculus	78-81
30785201-4	2019	The strongest delta13C response to the pgm-induced starch deficiency was observed in N. sylvestris, with more negative delta13COM, delta13CR, and delta13C values for assimilates (i.e. sugars and starch) and organic acids (i.e. malate and citrate) in pgm mutants than in wild-type plants during a diel cycle.	Citric Acid	238-245	phosphoglucomutase	Arabidopsis thaliana	39-42
30945499-13	2019	Metabolic pathway enrichment analysis indicated that the protective effect of PC6-EA pretreatment was realized mainly by regulating pathways of glycolysis, gluconeogenesis, citric acid metabolism, pyruvate metabolism, ketone body metabolism, etc.	Citric Acid	173-184	proprotein convertase subtilisin/kexin type 5	Rattus norvegicus	78-81
30663303-4	2019	Moreover, Jurkat cells exposed to IAPP and AuNPs were characterized by quantifying their cytokine secretions with a localized surface plasmon resonance (LSPR) immunoassay, where a peak response was registered for the most toxic IAPP oligomers and most suppressed by citrate-coated AuNPs.	Citric Acid	266-273	islet amyloid polypeptide	Homo sapiens	34-38
30663303-4	2019	Moreover, Jurkat cells exposed to IAPP and AuNPs were characterized by quantifying their cytokine secretions with a localized surface plasmon resonance (LSPR) immunoassay, where a peak response was registered for the most toxic IAPP oligomers and most suppressed by citrate-coated AuNPs.	Citric Acid	266-273	islet amyloid polypeptide	Homo sapiens	228-232
30872788-3	2019	We found that the contents of citrate, cis-aconitate and succinate were increased, which were consistent with the expression of ATP-citrate synthase (ACS) and isocitrate dehydrogenase (IDH) genes in cold-treated tomato fruit.	Citric Acid	30-37	1-aminocyclopropane-1-carboxylate synthase 2	Solanum lycopersicum	128-148
30872788-3	2019	We found that the contents of citrate, cis-aconitate and succinate were increased, which were consistent with the expression of ATP-citrate synthase (ACS) and isocitrate dehydrogenase (IDH) genes in cold-treated tomato fruit.	Citric Acid	30-37	1-aminocyclopropane-1-carboxylate synthase 2	Solanum lycopersicum	150-153
30872788-4	2019	Cold stress promotes the expression of ACS and IDH which may increase the synthesis of citrate, cis-aconitate and succinate.	Citric Acid	87-94	1-aminocyclopropane-1-carboxylate synthase 2	Solanum lycopersicum	39-42
30850587-6	2019	The underlying mechanism mainly involves citrate-stimulated activation of the AKT/ERK/MMP2/9 signaling axis.	Citric Acid	41-48	mitogen-activated protein kinase 1	Mus musculus	82-85
30850587-6	2019	The underlying mechanism mainly involves citrate-stimulated activation of the AKT/ERK/MMP2/9 signaling axis.	Citric Acid	41-48	matrix metallopeptidase 2	Mus musculus	86-92
30726670-2	2019	In this work, we studied adsorption kinetics of an antimicrobial protein, regenerating islet-derived protein 3-alpha (REG3A), on the surface of as-synthesized citrate-capped AuNPs under the influence of lipopolysaccharides (LPSs), with a combined method of UV-vis spectroscopy, multivariate analysis, and molecular dockings.	Citric Acid	159-166	regenerating family member 3 alpha	Homo sapiens	74-116
30433807-9	2019	HCl perfusion and citric acid-induced cough caused Fos expressions in the nucleus of solitary tract (nTS), dorsal motor nucleus of the vagus (DMV), paratrigeminal nucleus (Pa5), and intermediate reticular nucleus (IRt), which was higher than HCl group, saline control group, citric acid-induced cough group, and blank group.	Citric Acid	18-29	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	51-54
30726670-2	2019	In this work, we studied adsorption kinetics of an antimicrobial protein, regenerating islet-derived protein 3-alpha (REG3A), on the surface of as-synthesized citrate-capped AuNPs under the influence of lipopolysaccharides (LPSs), with a combined method of UV-vis spectroscopy, multivariate analysis, and molecular dockings.	Citric Acid	159-166	regenerating family member 3 alpha	Homo sapiens	118-123
30445261-1	2019	Citrate-capped gold nanoparticles (AuNPs) modified with thrombin-binding aptamer are often implemented for colorimetric, fluorescent, and electrochemical detection of thrombin in an aqueous solution.	Citric Acid	0-7	coagulation factor II, thrombin	Homo sapiens	56-64
30891062-7	2019	Most of the functional categories altered by Gclc overexpression related to metabolism including Drug metabolism, Metabolism of xenobiotics by cytochrome P450, Glutathione metabolism, Starch and sucrose metabolism, Citrate cycle (TCA cycle), One carbon pool by folate.	Citric Acid	215-222	Glutamate-cysteine ligase catalytic subunit	Drosophila melanogaster	45-49
30445261-1	2019	Citrate-capped gold nanoparticles (AuNPs) modified with thrombin-binding aptamer are often implemented for colorimetric, fluorescent, and electrochemical detection of thrombin in an aqueous solution.	Citric Acid	0-7	coagulation factor II, thrombin	Homo sapiens	167-175
30445261-4	2019	Considering that fibrinogen stabilized citrate-capped AuNPs against a high-ionic-strength buffer, F-AuNPs efficiently catalyzed the NaBH4-mediated decrease of yellow 4-nitrophenol to colorless 4-aminophenol.	Citric Acid	39-46	fibrinogen beta chain	Homo sapiens	17-27
30458393-7	2019	A suitable linear relationship for citrate was obtained for the range of 0.5 to 1000 muM.	Citric Acid	35-42	latexin	Homo sapiens	85-88
30421319-1	2019	Succinate dehydrogenase (SDH) is an enzyme complex, composed of four protein subunits, that plays a role in both the citric acid cycle and the electron transport chain.	Citric Acid	117-128	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	0-23
30421319-1	2019	Succinate dehydrogenase (SDH) is an enzyme complex, composed of four protein subunits, that plays a role in both the citric acid cycle and the electron transport chain.	Citric Acid	117-128	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	25-28
30689204-1	2019	Mitochondrial aconitase is the second enzyme in the tricarboxylic acid (TCA) cycle catalyzing the interconversion of citrate into isocitrate and encoded by the nuclear gene ACO2.	Citric Acid	117-124	aconitase 2	Homo sapiens	0-23
30103843-8	2019	The results showed that 100-fold of Na+, K+, Mg2+, Ca2+, Cl-, SO42-, sorbitol, sucrose, fructose, citric acid, 40-fold of NO3-, glucose, sucrose, urea, and 10-fold of uric acid had no significant interference.	Citric Acid	98-109	NBL1, DAN family BMP antagonist	Homo sapiens	122-125
30689204-1	2019	Mitochondrial aconitase is the second enzyme in the tricarboxylic acid (TCA) cycle catalyzing the interconversion of citrate into isocitrate and encoded by the nuclear gene ACO2.	Citric Acid	117-124	aconitase 2	Homo sapiens	173-177
30794680-2	2019	Citrate synthase from M. sedula (MsCS) is an enzyme involved in the first step of the incomplete TCA/glyoxylate cycle by converting oxaloacetate and acetyl-CoA into citrate and coenzyme A.	Citric Acid	165-172	citrate synthase	Metallosphaera sedula	0-16
30741341-0	2019	Voltammetric immunosensor for E-cadherin promoter DNA methylation using a Fe3O4-citric acid nanocomposite and a screen-printed carbon electrode modified with poly(vinyl alcohol) and reduced graphene oxide.	Citric Acid	80-91	cadherin 1	Homo sapiens	30-40
30728179-5	2019	RESULTS: Compared with control mice, slc26a6-/- mice (previously shown to have low urinary citrate and to develop calcium oxalate stones) had a 40% decrease in urinary excretion of succinate, a 35% increase in serum succinate, and elevated plasma renin.	Citric Acid	91-98	solute carrier family 26, member 6	Mus musculus	37-44
30728179-9	2019	CONCLUSIONS: These findings reveal a succinate/citrate homeostatic pathway regulated by IRBIT that affects BP and biochemical risk of calcium oxalate stone formation, thus providing a potential molecular link between hypertension and lithogenesis.	Citric Acid	47-54	S-adenosylhomocysteine hydrolase-like 1	Mus musculus	88-93
30720737-1	2019	In this work, Sr0.3Ba0.4Pb0.3Fe12O19/(CuFe2O4)x (x = 2, 3, 4, and 5) as strongly exchange-coupled nanosized ferrites were fabricated using a one-pot sol-gel combustion method (citrate sol-gel method).	Citric Acid	176-183	frataxin	Homo sapiens	38-67
30586346-3	2019	RECENT FINDINGS: The liver-specific activation of bempedoic acid inhibits ACLY, a key enzyme linking glucose catabolism to lipogenesis by catalyzing the formation of acetyl-CoA from mitochondrial-derived citrate for de novo synthesis of fatty acids and cholesterol.	Citric Acid	204-211	ATP citrate lyase	Homo sapiens	74-78
30535738-3	2019	Furthermore, the effect of organic additives, sorbitol, and citric acid on catalyst compounds was investigated by temperature-programmed reduction analysis (H2-TPR).	Citric Acid	60-71	translocated promoter region, nuclear basket protein	Homo sapiens	160-163
30293044-1	2019	This study analyzes the effect of the addition of acetate, citrate, and nitrilotriacetate anions on the retention of Co(II) cations by the gamma-alumina surface in view of the preparation of alumina supported cobalt catalysts.	Citric Acid	59-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-123
30576924-7	2019	Citrate-regulated global PPARgamma expression was evidenced by the significant increase expression of PPARgamma in PC12 cell line.	Citric Acid	0-7	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	25-34
30850587-0	2019	Intracellular citrate accumulation by oxidized ATM-mediated metabolism reprogramming via PFKP and CS enhances hypoxic breast cancer cell invasion and metastasis.	Citric Acid	14-21	ataxia telangiectasia mutated	Mus musculus	47-50
30850587-0	2019	Intracellular citrate accumulation by oxidized ATM-mediated metabolism reprogramming via PFKP and CS enhances hypoxic breast cancer cell invasion and metastasis.	Citric Acid	14-21	phosphofructokinase, platelet	Mus musculus	89-93
30850587-0	2019	Intracellular citrate accumulation by oxidized ATM-mediated metabolism reprogramming via PFKP and CS enhances hypoxic breast cancer cell invasion and metastasis.	Citric Acid	14-21	citrate synthase	Mus musculus	98-100
30850587-3	2019	Here we find that hypoxia (1% O2) induces DNA damage-independent ATM activation (oxidized ATM) and suppression of oxidized ATM reduces intracellular citrate via decreasing the levels of phosphofructokinase (PFKP) and citrate synthase (CS), two key glucose metabolism-associated enzymes.	Citric Acid	149-156	phosphofructokinase, platelet	Mus musculus	207-211
30850587-3	2019	Here we find that hypoxia (1% O2) induces DNA damage-independent ATM activation (oxidized ATM) and suppression of oxidized ATM reduces intracellular citrate via decreasing the levels of phosphofructokinase (PFKP) and citrate synthase (CS), two key glucose metabolism-associated enzymes.	Citric Acid	149-156	citrate synthase	Mus musculus	217-233
30850587-3	2019	Here we find that hypoxia (1% O2) induces DNA damage-independent ATM activation (oxidized ATM) and suppression of oxidized ATM reduces intracellular citrate via decreasing the levels of phosphofructokinase (PFKP) and citrate synthase (CS), two key glucose metabolism-associated enzymes.	Citric Acid	149-156	citrate synthase	Mus musculus	235-237
30576924-7	2019	Citrate-regulated global PPARgamma expression was evidenced by the significant increase expression of PPARgamma in PC12 cell line.	Citric Acid	0-7	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	102-111
30426593-6	2019	Metabolome analysis of lymphoma cells in coculture with CAF demonstrated that intermediates in the citric acid cycle were significantly increased, indicating that tumor cells produced energy by aerobic metabolism.	Citric Acid	99-110	lysine acetyltransferase 2B	Homo sapiens	56-59
30099315-2	2019	CQDs with citric acid as a carbon source and diethylenetriamine as a nitrogen doping agent were directly synthesized in MCM-41 via a hydrothermal method and the reaction conditions were optimized.	Citric Acid	10-21	methylmalonyl-CoA mutase	Homo sapiens	120-123
30446806-3	2019	In addition, CaSR increases water and proton excretion in the collecting duct and promotes phosphate reabsorption and citrate excretion in the proximal tubule.	Citric Acid	118-125	calcium sensing receptor	Homo sapiens	13-17
30666555-0	2019	Colorimetric determination of ascorbic acid and the activity of alkaline phosphatase based on the inhibition of the peroxidase-like activity of citric acid-capped Prussian Blue nanocubes.	Citric Acid	144-155	alkaline phosphatase, placental	Homo sapiens	64-84
30582451-10	2019	Chromatin immunoprecipitation sequencing analyses showed that PFKFB3 is required for citrate-dependent H3K27 acetylation at enhancer sites of genes regulated by the acetyl transferase p300 and by N1ICD or the N1ICD target MYC and necessary for EC proliferation and homeostasis.	Citric Acid	85-92	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Mus musculus	62-68
30586707-6	2019	The toll-like receptor 3 agonist poly I:C increased expression of the mitochondrial citrate transporter Slc25A1, and the nuclear ATP-citrate lyase, in association with intracellular accumulation of citrate, the precursor for acetyl coenzyme A.	Citric Acid	84-91	solute carrier family 25 member 1	Homo sapiens	104-111
30426593-7	2019	These findings indicate that energy production in lymphoma cells is regulated in coordination not only with anaerobic glycolysis, but also with aerobic metabolism termed the reverse-Warburg effect, involving the secretion of pyruvate from CAF resulting in increased use of the citric acid cycle in lymphoma cells.	Citric Acid	277-288	lysine acetyltransferase 2B	Homo sapiens	239-242
29745322-3	2019	In this context most of citrate is diverted from Krebs cycle and channeled into the "citrate pathway" consisting in the increase of the export of citrate into cytosol by the mitochondrial citrate carrier followed by its cleavage into acetyl-CoA and oxaloacetate by ATP citrate lyase.	Citric Acid	24-31	ATP citrate lyase	Homo sapiens	265-282
29745322-3	2019	In this context most of citrate is diverted from Krebs cycle and channeled into the "citrate pathway" consisting in the increase of the export of citrate into cytosol by the mitochondrial citrate carrier followed by its cleavage into acetyl-CoA and oxaloacetate by ATP citrate lyase.	Citric Acid	85-92	ATP citrate lyase	Homo sapiens	265-282
29745322-3	2019	In this context most of citrate is diverted from Krebs cycle and channeled into the "citrate pathway" consisting in the increase of the export of citrate into cytosol by the mitochondrial citrate carrier followed by its cleavage into acetyl-CoA and oxaloacetate by ATP citrate lyase.	Citric Acid	85-92	ATP citrate lyase	Homo sapiens	265-282
29745322-3	2019	In this context most of citrate is diverted from Krebs cycle and channeled into the "citrate pathway" consisting in the increase of the export of citrate into cytosol by the mitochondrial citrate carrier followed by its cleavage into acetyl-CoA and oxaloacetate by ATP citrate lyase.	Citric Acid	85-92	ATP citrate lyase	Homo sapiens	265-282
29745322-7	2019	Inhibition of CIC or ACLY by different synthetic and natural molecules results in reduction of NO, ROS and PGE2 levels suggesting that the citrate pathway can be a new target to be addressed in inflammation.	Citric Acid	139-146	ATP citrate lyase	Homo sapiens	21-25
30478052-3	2018	Our studies show that extracellular citrate uptake through solute carrier family 13, member 5 (SLC13a5) supports osteogenic differentiation via regulation of energy-producing metabolic pathways, leading to elevated cell energy status that fuels the high metabolic demands of hMSC osteodifferentiation.	Citric Acid	36-43	solute carrier family 13 member 5	Homo sapiens	59-93
31230273-5	2019	Citrate, often found as a contaminant in serum albumin, may have an essential role in rabbit blastocyst growth, which would fit in with its role in the development of serum-free media for culture of various types of mammalian cells.A comprehensive account of the methodology is given to enable a researcher with experience culturing embryos of a different species to work on the rabbit embryo.	Citric Acid	0-7	albumin	Homo sapiens	47-54
30606780-7	2019	Consistent with the increased amounts of citrate, isotope-labeling experiments revealed that respiration through the tricarboxylic acid cycle was enhanced in srk2d srk2e srk2i These results, together with transcriptome data, indicate that the SnRK2s involved in ABA signaling modulate metabolism and leaf growth under nonstress conditions by fine-tuning flux through the tricarboxylic acid cycle.	Citric Acid	41-48	SNF1-related protein kinase 2.2	Arabidopsis thaliana	158-163
30606780-7	2019	Consistent with the increased amounts of citrate, isotope-labeling experiments revealed that respiration through the tricarboxylic acid cycle was enhanced in srk2d srk2e srk2i These results, together with transcriptome data, indicate that the SnRK2s involved in ABA signaling modulate metabolism and leaf growth under nonstress conditions by fine-tuning flux through the tricarboxylic acid cycle.	Citric Acid	41-48	Protein kinase superfamily protein	Arabidopsis thaliana	164-169
30686542-16	2019	CONCLUSION: Dialysis with citrate acutely produces less postdialysis alkalemia and significantly modifies Ca, Mg and PTH.	Citric Acid	26-33	parathyroid hormone	Homo sapiens	117-120
30581893-4	2019	Citrate, the standard apheresis anticoagulant, chelates ionized calcium with consequent perturbations of serum calcium, parathyroid hormone, vitamin D, and markers of bone remodeling in donors.	Citric Acid	0-7	parathyroid hormone	Homo sapiens	120-139
30478052-3	2018	Our studies show that extracellular citrate uptake through solute carrier family 13, member 5 (SLC13a5) supports osteogenic differentiation via regulation of energy-producing metabolic pathways, leading to elevated cell energy status that fuels the high metabolic demands of hMSC osteodifferentiation.	Citric Acid	36-43	solute carrier family 13 member 5	Homo sapiens	95-102
30291581-2	2018	Citrate was incubated with 50 muM Eu3+-tetracycline and the complex separated using capillary electrophoresis utilizing post-column laser-induced luminescence detection in a sheath flow cuvette.	Citric Acid	0-7	latexin	Homo sapiens	30-33
30446220-6	2018	In this study, we determined the structure of human p49 at 2.2 A resolution with citrate in its inactive forms.	Citric Acid	81-88	DNA primase subunit 1	Homo sapiens	52-55
30446220-9	2018	We further demonstrated that the p49 activity is regulated by pH and citrate, which was not previously recognized as a key regulator of DNA replication.	Citric Acid	69-76	DNA primase subunit 1	Homo sapiens	33-36
30107042-9	2018	Compared to the carbonate-treated group, the following bone turnover markers decreased significantly in the citrate-treated group: procollagen I N-terminal propeptide (-16.6% vs -3.2%, P = 0.021), osteocalcin (-17.2% vs -4.3%, P = 0.007) and bone-specific alkaline phosphatase (-5.9% vs 3.7%, P = 0.027) and remained significantly decreased after multivariable adjustment.	Citric Acid	108-115	bone gamma-carboxyglutamate protein	Homo sapiens	197-208
30291581-3	2018	Signal was linear with citrate concentration from 10 muM to 200 nM.	Citric Acid	23-30	latexin	Homo sapiens	53-56
30564403-2	2018	We proposed a simple and convenient wet-state SERS method for uranyl detection based on the citrate-stabilized silver nanoparticles.	Citric Acid	92-99	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	46-50
29774548-8	2018	RESULTS: Ten percent citric acid released the greatest amount of TGF-beta1 amongst all groups, which was significantly different to 17% EDTA (P &lt; 0.01).	Citric Acid	21-32	transforming growth factor beta 1	Homo sapiens	65-74
29774548-11	2018	CONCLUSIONS: Ten percent citric acid was effective as a final irrigant for releasing TGF-beta1 with good biocompatibility in regenerative endodontics.	Citric Acid	25-36	transforming growth factor beta 1	Homo sapiens	85-94
30140954-9	2018	The results obtained from the renal expression of NaDC1 could explain an adaptive mechanism to prevent the formation of kidney stones by increasing the levels of citrate, a calcium chelator.	Citric Acid	162-169	solute carrier family 13 member 2	Rattus norvegicus	50-55
30565175-3	2018	In this work, we have synthesized human serum albumin-coated citrate-functionalized iron oxide nanoparticles by CDI coupling.	Citric Acid	61-68	albumin	Homo sapiens	46-53
30053689-2	2018	Inspired by the role of citrate in the growth of apatite crystals during natural bio-mineralization, uniform and nearly monodisperse Eu3+-doped CaF2 nanoparticles with excellent colloidal stability and high fluorescence in aqueous media have been successfully synthesized in the presence of sodium citrate using a hydrothermal method.	Citric Acid	24-31	CCR4-NOT transcription complex subunit 8	Homo sapiens	144-148
30419358-0	2018	Structural and biochemical characterization of citrate binding to AtPPC3, a plant-type phosphoenolpyruvate carboxylase from Arabidopsis thaliana.	Citric Acid	47-54	phosphoenolpyruvate carboxylase 3	Arabidopsis thaliana	66-72
30419358-2	2018	The structure of AtPPC3, a C3 PEPC isozyme of the model plant Arabidopsis thaliana, in complex with the inhibitors aspartate and citrate was solved at 2.2-A resolution.	Citric Acid	129-136	phosphoenolpyruvate carboxylase 3	Arabidopsis thaliana	17-23
30419358-2	2018	The structure of AtPPC3, a C3 PEPC isozyme of the model plant Arabidopsis thaliana, in complex with the inhibitors aspartate and citrate was solved at 2.2-A resolution.	Citric Acid	129-136	phosphoenolpyruvate carboxylase	Solanum tuberosum	30-34
30419358-3	2018	This represents the first PEPC structure with citrate bound.	Citric Acid	46-53	phosphoenolpyruvate carboxylase	Solanum tuberosum	26-30
30419358-5	2018	Citrate functions as a mixed (allosteric) inhibitor as it reduced AtPPC3"s Vmax while increasing Km(PEP) values.	Citric Acid	0-7	phosphoenolpyruvate carboxylase 3	Arabidopsis thaliana	66-72
30419358-5	2018	Citrate functions as a mixed (allosteric) inhibitor as it reduced AtPPC3"s Vmax while increasing Km(PEP) values.	Citric Acid	0-7	RNA-binding KH domain-containing protein	Arabidopsis thaliana	100-103
30419358-6	2018	The PEP saturation data gave an excellent fit to the mixed inhibition model, yielding Ki and Ki" (citrate) values of 9.3 and 42.5 mM, respectively.	Citric Acid	98-105	RNA-binding KH domain-containing protein	Arabidopsis thaliana	4-7
30419358-7	2018	Citrate and aspartate inhibition of AtPPC3 was non-additive, likely due to their closely positioned binding sites, their similar negative charge, and type of binding residues.	Citric Acid	0-7	phosphoenolpyruvate carboxylase 3	Arabidopsis thaliana	36-42
30419358-8	2018	Fewer interactions and lower affinity for citrate support its observed weaker inhibition of AtPPC3 relative to aspartate.	Citric Acid	42-49	phosphoenolpyruvate carboxylase 3	Arabidopsis thaliana	92-98
30419358-11	2018	The cytosolic citrate concentration of potato tubers suggests that AtPPC3"s inhibition by citrate may be physiologically relevant.	Citric Acid	14-21	phosphoenolpyruvate carboxylase 3	Arabidopsis thaliana	67-73
30419358-11	2018	The cytosolic citrate concentration of potato tubers suggests that AtPPC3"s inhibition by citrate may be physiologically relevant.	Citric Acid	90-97	phosphoenolpyruvate carboxylase 3	Arabidopsis thaliana	67-73
30397150-6	2018	The discovery that the Zn-depleted middle-aged rat prostate has a metabolic phenotype resembling that of human prostate cancer, with a 10-fold down-regulation of citric acid (P = 0.0003), links citrate reduction directly to prostatic Zn loss, providing the underlying mechanism linking dietary Zn deficiency with miR-183-96-182 overexpression, ZIP1 down-regulation, prostatic Zn loss, and the resultant citrate down-regulation, changes mimicking features of human prostate cancer.	Citric Acid	194-201	solute carrier family 39 member 1	Homo sapiens	344-348
30428349-2	2018	The endogenous metabolite citrate has recently emerged as a modulator of DC activation.	Citric Acid	26-33	decorin	Mus musculus	73-75
30428349-5	2018	Metabolic analysis revealed that the citrate increase induced by lipopolysaccharide (LPS) is impaired in p32-deficient DCs.	Citric Acid	37-44	complement component 1, q subcomponent binding protein	Mus musculus	105-108
30428349-7	2018	Therefore, we suggest that DC maturation is regulated by citrate production via p32-dependent PDH activity.	Citric Acid	57-64	decorin	Mus musculus	27-29
30428349-7	2018	Therefore, we suggest that DC maturation is regulated by citrate production via p32-dependent PDH activity.	Citric Acid	57-64	complement component 1, q subcomponent binding protein	Mus musculus	80-83
30455595-4	2018	Among the potential activators of FBP listed by Liu and Zhang, citrate was surprisingly not mentioned although it is an activator of FBPase, also demonstrating various anti-cancer effects in pre-clinical studies.	Citric Acid	63-70	ECB2	Homo sapiens	34-37
30891326-9	2018	As a result, PKM2 reduced glucose levels reserved for intracellular utilization, particularly for the production of citrate, and thus increased the alpha-ketoglutarate/citrate ratio to promote the generation of glutamine-derived acetyl-coenzyme A through the reductive pathway.	Citric Acid	168-175	pyruvate kinase, muscle	Mus musculus	13-17
30891326-9	2018	As a result, PKM2 reduced glucose levels reserved for intracellular utilization, particularly for the production of citrate, and thus increased the alpha-ketoglutarate/citrate ratio to promote the generation of glutamine-derived acetyl-coenzyme A through the reductive pathway.	Citric Acid	116-123	pyruvate kinase, muscle	Mus musculus	13-17
30021702-7	2018	SGLT2 inhibition as well as calorie restriction almost completely eliminated citrate accumulation in the cortex.	Citric Acid	77-84	solute carrier family 5 (sodium/glucose cotransporter), member 2	Mus musculus	0-5
30121429-1	2018	The vacuolar H+-ATPase (V-ATPase) proton pump plays an important role in the acidification of vacuoles; however, genes encoding V-ATPase in the citrus genome and their roles in citric acid accumulation remain unclear in citrus fruit.	Citric Acid	177-188	V-type proton ATPase catalytic subunit A	Citrus sinensis	4-22
30121429-1	2018	The vacuolar H+-ATPase (V-ATPase) proton pump plays an important role in the acidification of vacuoles; however, genes encoding V-ATPase in the citrus genome and their roles in citric acid accumulation remain unclear in citrus fruit.	Citric Acid	177-188	V-type proton ATPase catalytic subunit A	Citrus sinensis	24-32
30121429-1	2018	The vacuolar H+-ATPase (V-ATPase) proton pump plays an important role in the acidification of vacuoles; however, genes encoding V-ATPase in the citrus genome and their roles in citric acid accumulation remain unclear in citrus fruit.	Citric Acid	177-188	V-type proton ATPase catalytic subunit A	Citrus sinensis	128-136
30121429-9	2018	The lower activity of V-ATPase caused by the transcript reduction of some subunit genes may be one reason for the low citrate accumulation in "HAL" juice sacs.	Citric Acid	118-125	V-type proton ATPase catalytic subunit A	Citrus sinensis	22-30
30224277-6	2018	By evaluating the total ion chromatograms (TIC) on GC-Orbitrap-MS of different extracts using various sorbents, QuEChERS citrate using EMR-Lipid sorbent resulted in the cleanest extract among Z-Sep, Primary secondary amine (PSA), Oasis  Prime HLB, and Supelclean  Ultra cartridges that consist of a top bed of PSA, C18 and Grashsphere  2031 and a bottom bed of Z-Sep. Later, the analyses were performed on a GC-QQQ-MS/MS, applying a 15 min runtime method covering 205 compounds.	Citric Acid	121-128	Bardet-Biedl syndrome 9	Homo sapiens	315-318
30150300-10	2018	beta-Catenin activity is maintained by acetylation, and mitochondria generate the acetyl donor acetyl-CoA, which upon entering the Krebs cycle is converted to citrate capable of exiting mitochondria.	Citric Acid	159-166	catenin (cadherin associated protein), beta 1	Mus musculus	0-12
30140954-7	2018	The renal expression of NaDC1 was decreased in BUO5 and BUO24, with a concomitant increase in urinary excretion of citrate.	Citric Acid	115-122	solute carrier family 13 member 2	Rattus norvegicus	24-29
30323304-4	2018	The amino acids glycine and phenylalanine and the energy metabolites citrate and glycerol were negatively associated with eGFR in all the cohorts, while alanine, valine and pyruvate depicted opposite association in diabetics (positive) and non-diabetics (negative).	Citric Acid	69-76	epidermal growth factor receptor	Homo sapiens	122-126
30150300-11	2018	Cytosolic citrate is converted back to acetyl-CoA by ATP citrate lyase (ACLY).	Citric Acid	10-17	ATP citrate lyase	Mus musculus	53-70
30150300-11	2018	Cytosolic citrate is converted back to acetyl-CoA by ATP citrate lyase (ACLY).	Citric Acid	10-17	ATP citrate lyase	Mus musculus	72-76
29672123-6	2018	MEASUREMENTS AND MAIN RESULTS: Intratracheal instillation of IFN-gamma enhanced the cough response to citric acid in vivo.	Citric Acid	102-113	interferon gamma	Rattus norvegicus	61-70
30195238-1	2018	ATP citrate lyase (ACLY) is a cytosolic homotetrameric enzyme that catalyzes the conversion of citrate and coenzyme A (CoA) to acetyl-CoA and oxaloacetate, with the simultaneous hydrolysis of ATP to ADP and phosphate.	Citric Acid	4-11	ATP citrate lyase	Homo sapiens	19-23
29638199-10	2018	CONCLUSION: This study investigates CD11b levels in response to an air stimulus in blood that was anticoagulated with citrate or heparin.	Citric Acid	118-125	integrin subunit alpha M	Homo sapiens	36-41
29638199-12	2018	Activation of CD11b was less when using heparin as an anticoagulant compared to citrate.	Citric Acid	80-87	integrin subunit alpha M	Homo sapiens	14-19
29383416-2	2018	Here we investigate if the apical CaSR in the proximal tubule also prevents stone formation acting via regulation of apical dicarboxylate and citrate transport.	Citric Acid	142-149	calcium sensing receptor	Homo sapiens	34-38
29981745-10	2018	KDM5B was especially resistant to inhibition by R-2HG, while citrate was the most efficient inhibitor of KDM6B.	Citric Acid	61-68	lysine demethylase 6B	Homo sapiens	105-110
30195238-4	2018	Once transported to the cytosol, citrate is here converted by ACLY to acetyl-CoA, an essential biosynthetic precursor for fatty acid synthesis and mevalonate pathway.	Citric Acid	33-40	ATP citrate lyase	Homo sapiens	62-66
29986283-0	2018	Effects of the food additives sodium acid pyrophosphate, sodium acetate, and citric acid on hemato-immunological pathological biomarkers in rats: Relation to PPAR-alpha, PPAR-gamma and tnfalpha signaling pathway.	Citric Acid	77-88	peroxisome proliferator activated receptor alpha	Rattus norvegicus	158-168
30049710-7	2018	The lipid storage defects in dSeipin mutant fat cells can be rescued by replenishing mitochondrial calcium or by restoring the level of citrate through genetic manipulations or supplementation with exogenous metabolites.	Citric Acid	136-143	seipin	Drosophila melanogaster	29-36
30274007-0	2018	Effects of Freeze-Thaw Times on Screening Coagulation Tests and Factors VIII and IX Activities in Citrate-Anticoagulated Plasma at -20 C and -80 C. BACKGROUND: Accurate determination of screening coagulation tests and factors VIII and IX activities (FVIII:C and FIX:C) in fresh plasma is very important for diagnosing abnormalities in the intrinsic or extrinsic coagulation pathways and factor deficiencies.	Citric Acid	98-105	cytochrome c oxidase subunit 8A	Homo sapiens	72-76
29986283-0	2018	Effects of the food additives sodium acid pyrophosphate, sodium acetate, and citric acid on hemato-immunological pathological biomarkers in rats: Relation to PPAR-alpha, PPAR-gamma and tnfalpha signaling pathway.	Citric Acid	77-88	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	170-180
29986283-0	2018	Effects of the food additives sodium acid pyrophosphate, sodium acetate, and citric acid on hemato-immunological pathological biomarkers in rats: Relation to PPAR-alpha, PPAR-gamma and tnfalpha signaling pathway.	Citric Acid	77-88	tumor necrosis factor	Rattus norvegicus	185-193
29396649-7	2018	By using CPT1A floxed mice, we have observed that genetic ablation of CPT1A recapitulates the effect of ghrelin on GABA release in cortical neurons, inducing reductions in mitochondrial oxygen consumption, cell content of citrate and alpha-ketoglutarate, and GABA shunt enzyme activity.	Citric Acid	222-229	carnitine palmitoyltransferase 1a, liver	Mus musculus	70-75
30155711-2	2018	Sodium-dicarboxylate cotransporter-1 (NaDC-1) is a main transporter responsible for citrate reabsorption in renal proximal tubules.	Citric Acid	84-91	solute carrier family 13 member 2	Homo sapiens	38-44
29935209-11	2018	sMAC results stayed around 81% of baseline in serum and 47% in citrate plasma with 50mug/mL ECU.	Citric Acid	63-70	diablo IAP-binding mitochondrial protein	Homo sapiens	0-4
29396649-7	2018	By using CPT1A floxed mice, we have observed that genetic ablation of CPT1A recapitulates the effect of ghrelin on GABA release in cortical neurons, inducing reductions in mitochondrial oxygen consumption, cell content of citrate and alpha-ketoglutarate, and GABA shunt enzyme activity.	Citric Acid	222-229	ghrelin	Mus musculus	104-111
30906855-0	2018	Thermoresponsive Citrate-Based Graphene Oxide Scaffold Enhances Bone Regeneration from BMP9-Stimulated Adipose-Derived Mesenchymal Stem Cells.	Citric Acid	17-24	growth differentiation factor 2	Mus musculus	87-91
29784665-8	2018	Interestingly, decreased triglyceride accumulation observed upon SREBF1 inhibition is paralleled by an increase in mitochondrial respiration, indicating a potential rewiring of citrate metabolism in prostate cancer cells.	Citric Acid	177-184	sterol regulatory element binding transcription factor 1	Homo sapiens	65-71
29784665-9	2018	Altogether, these data define an AR/mTOR nuclear axis, in the context of prostate cancer, as a novel pathway regulating SREBF1 activity and citrate metabolism.Implications: The finding that an AR/mTOR complex promotes SREBF1 expression and activity enhances our understanding of the metabolic adaptation necessary for prostate cancer cell growth and suggests novel therapeutic approaches to target metabolic vulnerabilities in tumors.	Citric Acid	140-147	androgen receptor	Homo sapiens	33-35
29784665-9	2018	Altogether, these data define an AR/mTOR nuclear axis, in the context of prostate cancer, as a novel pathway regulating SREBF1 activity and citrate metabolism.Implications: The finding that an AR/mTOR complex promotes SREBF1 expression and activity enhances our understanding of the metabolic adaptation necessary for prostate cancer cell growth and suggests novel therapeutic approaches to target metabolic vulnerabilities in tumors.	Citric Acid	140-147	mechanistic target of rapamycin kinase	Homo sapiens	36-40
29784665-9	2018	Altogether, these data define an AR/mTOR nuclear axis, in the context of prostate cancer, as a novel pathway regulating SREBF1 activity and citrate metabolism.Implications: The finding that an AR/mTOR complex promotes SREBF1 expression and activity enhances our understanding of the metabolic adaptation necessary for prostate cancer cell growth and suggests novel therapeutic approaches to target metabolic vulnerabilities in tumors.	Citric Acid	140-147	androgen receptor	Homo sapiens	193-195
29784665-9	2018	Altogether, these data define an AR/mTOR nuclear axis, in the context of prostate cancer, as a novel pathway regulating SREBF1 activity and citrate metabolism.Implications: The finding that an AR/mTOR complex promotes SREBF1 expression and activity enhances our understanding of the metabolic adaptation necessary for prostate cancer cell growth and suggests novel therapeutic approaches to target metabolic vulnerabilities in tumors.	Citric Acid	140-147	mechanistic target of rapamycin kinase	Homo sapiens	196-200
29784665-9	2018	Altogether, these data define an AR/mTOR nuclear axis, in the context of prostate cancer, as a novel pathway regulating SREBF1 activity and citrate metabolism.Implications: The finding that an AR/mTOR complex promotes SREBF1 expression and activity enhances our understanding of the metabolic adaptation necessary for prostate cancer cell growth and suggests novel therapeutic approaches to target metabolic vulnerabilities in tumors.	Citric Acid	140-147	sterol regulatory element binding transcription factor 1	Homo sapiens	218-224
30906855-0	2018	Thermoresponsive Citrate-Based Graphene Oxide Scaffold Enhances Bone Regeneration from BMP9-Stimulated Adipose-Derived Mesenchymal Stem Cells.	Citric Acid	17-24	WD and tetratricopeptide repeats 1	Mus musculus	103-110
30906855-4	2018	We previously showed that BMP9 is the most osteogenic BMP and induces robust bone formation of immortalized mouse adipose-derived MSCs entrapped in a citrate-based thermoresponsive hydrogel referred to as PPCNg.	Citric Acid	150-157	growth differentiation factor 2	Mus musculus	26-30
29929979-3	2018	Hence, we studied chondrocyte ATP-citrate lyase (ACLY), which generates acetyl-CoA from mitochondrial-derived citrate, and modulates acetylation of histones and transcription factors.	Citric Acid	34-41	ATP citrate lyase	Homo sapiens	49-53
30224979-2	2018	The citric acid-modified resins PS-CA, PS-O-CA and PS-N-CA were synthesized by anchoring citric acid on PS-Cl, PS-OH and PS-NH2, respectively.	Citric Acid	4-15	prostate stem cell antigen	Homo sapiens	32-37
30224979-2	2018	The citric acid-modified resins PS-CA, PS-O-CA and PS-N-CA were synthesized by anchoring citric acid on PS-Cl, PS-OH and PS-NH2, respectively.	Citric Acid	89-100	prostate stem cell antigen	Homo sapiens	32-37
29616790-4	2018	Moreover, its citrate (3c Cit) possessed improved water solubility and good effects against scopolamine-induced cognitive impairment with inhibition of cortical AChE activities and enhancement of cAMP response element-binding protein (CREB) phosphorylation ex vivo.	Citric Acid	14-21	acetylcholinesterase	Mus musculus	161-165
29772249-5	2018	RESULTS: Decreased mean live CD45+ cell counts were observed after storage of biopsies at -80  C dimethyl sulfoxide (DMSO)/citrate buffer compared with immediate processing (1794.3 vs. 19,672.7; p = 0.006]).	Citric Acid	123-130	protein tyrosine phosphatase receptor type C	Homo sapiens	29-33
29772249-6	2018	A non-significant decrease in CD45+ live cell count occurred after storage at -20  C in DMSO/citrate buffer and cell yield was adequate for subsequent analysis.	Citric Acid	93-100	protein tyrosine phosphatase receptor type C	Homo sapiens	30-34
29772249-8	2018	Mean CD14+ cell proportions were significantly higher after storage of biopsies at -80  C in DMSO/citrate buffer compared with immediate analysis (2.61% vs. 1.31%, p = 0.007).	Citric Acid	98-105	CD14 molecule	Homo sapiens	5-9
30040959-11	2018	Consistent down-regulation of isocitrate dehydrogenase encoding idhg-1 gene which is among the rate-controlling enzymes of the citric acid cycle was considered as main biochemical factor involved in the nematicidal activity of honey and MRJP-containing glycoproteins.	Citric Acid	127-138	Isocitrate dehydrogenase [NAD] subunit, mitochondrial	Caenorhabditis elegans	64-70
30054523-1	2018	The human uptake transporter NaCT is important for human brain development, brain function and energy metabolism and mediates the uptake of citrate and other intermediates of the tricarboxylic acid cycle from blood into neurons and hepatocytes.	Citric Acid	140-147	solute carrier family 13 member 5	Homo sapiens	29-33
30054523-5	2018	Furthermore, the impact on NaCT-mediated citrate uptake was measured.	Citric Acid	41-48	solute carrier family 13 member 5	Homo sapiens	27-31
29616790-4	2018	Moreover, its citrate (3c Cit) possessed improved water solubility and good effects against scopolamine-induced cognitive impairment with inhibition of cortical AChE activities and enhancement of cAMP response element-binding protein (CREB) phosphorylation ex vivo.	Citric Acid	14-21	cAMP responsive element binding protein 1	Mus musculus	196-233
29616790-4	2018	Moreover, its citrate (3c Cit) possessed improved water solubility and good effects against scopolamine-induced cognitive impairment with inhibition of cortical AChE activities and enhancement of cAMP response element-binding protein (CREB) phosphorylation ex vivo.	Citric Acid	14-21	cAMP responsive element binding protein 1	Mus musculus	235-239
30012170-11	2018	Mechanistically, by suppressing PDHX, miR-27b altered levels of pyruvate, lactate and citrate, as well as reducing mitochondrial oxidation and promoting extracellular acidification.	Citric Acid	86-93	pyruvate dehydrogenase complex component X	Homo sapiens	32-36
30012170-11	2018	Mechanistically, by suppressing PDHX, miR-27b altered levels of pyruvate, lactate and citrate, as well as reducing mitochondrial oxidation and promoting extracellular acidification.	Citric Acid	86-93	microRNA 27b	Homo sapiens	38-45
30093983-6	2018	Citrate production, along with growth and proliferation by these cells, is regulated by co-existing testosterone and prolactin signaling pathways; and by the oncogenic down-regulation of ZIP1 transporter/zinc/citrate in the development of malignancy.	Citric Acid	0-7	prolactin	Homo sapiens	117-126
30059044-2	2018	By using citrate-stabilized gold nanoparticles (mean diameter: 13 nm) and cellulose acetate membranes, gold nanoparticle-embedded cellulose acetate membranes (Au-CAM) have easily been fabricated.	Citric Acid	9-16	calmodulin 3	Homo sapiens	162-165
30093983-6	2018	Citrate production, along with growth and proliferation by these cells, is regulated by co-existing testosterone and prolactin signaling pathways; and by the oncogenic down-regulation of ZIP1 transporter/zinc/citrate in the development of malignancy.	Citric Acid	0-7	solute carrier family 39 member 1	Homo sapiens	187-191
30093983-6	2018	Citrate production, along with growth and proliferation by these cells, is regulated by co-existing testosterone and prolactin signaling pathways; and by the oncogenic down-regulation of ZIP1 transporter/zinc/citrate in the development of malignancy.	Citric Acid	209-216	solute carrier family 39 member 1	Homo sapiens	187-191
29651165-0	2018	The mitochondrial citrate carrier, SLC25A1, drives stemness and therapy resistance in non-small cell lung cancer.	Citric Acid	18-25	solute carrier family 25 member 1	Homo sapiens	35-42
29412702-0	2018	alpha-Ketoglutarate stimulates pendrin-dependent Cl- absorption in the mouse CCD through protein kinase C. alpha-Ketoglutarate (alpha-KG) is a citric acid cycle intermediate and a glutamine catabolism product.	Citric Acid	143-154	solute carrier family 26, member 4	Mus musculus	31-38
29853564-12	2018	Inhibition of ATP citrate lyase, which generates acetyl-CoA from citrate, also decreased Period 2 occupancy, with concomitant upregulation of Abcg5/8.	Citric Acid	18-25	period circadian clock 2	Mus musculus	89-97
29853564-12	2018	Inhibition of ATP citrate lyase, which generates acetyl-CoA from citrate, also decreased Period 2 occupancy, with concomitant upregulation of Abcg5/8.	Citric Acid	18-25	ATP binding cassette subfamily G member 5	Mus musculus	142-147
29651165-5	2018	We demonstrate that SLC25A1 plays a key role in maintaining the mitochondrial pool of citrate and redox balance in CSCs, whereas its inhibition leads to reactive oxygen species build-up thereby inhibiting the self-renewal capability of CSCs.	Citric Acid	86-93	solute carrier family 25 member 1	Homo sapiens	20-27
29442644-3	2018	Iron-carboxylate MOF (Fe-MOF) was synthesized by the novel cetyltrimethylammonium bromide (CTAB)-citric acid (CA) double-template method.	Citric Acid	97-108	lysine acetyltransferase 8	Homo sapiens	17-20
29877121-0	2018	Association of cough hypersensitivity with tracheal TRPV1 activation and neurogenic inflammation in a novel guinea pig model of citric acid-induced chronic cough.	Citric Acid	128-139	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	52-57
29877121-8	2018	The areas of TRPV1 positivity in the trachea and bronchi of citric acid-treated animals were significantly larger than in the control group.	Citric Acid	60-71	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	13-18
29442644-3	2018	Iron-carboxylate MOF (Fe-MOF) was synthesized by the novel cetyltrimethylammonium bromide (CTAB)-citric acid (CA) double-template method.	Citric Acid	97-108	lysine acetyltransferase 8	Homo sapiens	25-28
29425105-6	2018	EDTA plasma samples with a pre-centrifugation delay longer than 48 h had an IL16 concentration higher than 897 pg/mL, citrate plasma samples had an IL8 concentration higher than 21.5 pg/mL and serum samples had an IL8 concentration higher than 528 pg/mL.	Citric Acid	118-125	C-X-C motif chemokine ligand 8	Homo sapiens	148-151
29601126-1	2018	Malic enzyme 1 (ME1) is a multifunctional protein involved in glycolysis, the citric acid cycle, NADPH production, glutamine metabolism, and lipogenesis.	Citric Acid	78-89	malic enzyme 1	Homo sapiens	0-14
29874573-6	2018	In addition, we show that the specific inhibition of SDHA degradation by UPS promotes SDHA-dependent oxygen consumption and increases ATP, malate, and citrate levels.	Citric Acid	151-158	succinate dehydrogenase complex flavoprotein subunit A	Homo sapiens	53-57
30050389-3	2018	Citrate is an intermediary metabolite synthesized in mitochondria, and when transported into the cytosol by the mitochondrial citrate carrier-SLC25A1-encoded protein-it is cleaved into acetyl-CoA and oxaloacetate by ATP citrate lyase (ACLY).	Citric Acid	0-7	solute carrier family 25 member 1	Homo sapiens	142-149
30050389-3	2018	Citrate is an intermediary metabolite synthesized in mitochondria, and when transported into the cytosol by the mitochondrial citrate carrier-SLC25A1-encoded protein-it is cleaved into acetyl-CoA and oxaloacetate by ATP citrate lyase (ACLY).	Citric Acid	0-7	ATP citrate lyase	Homo sapiens	216-233
30050389-3	2018	Citrate is an intermediary metabolite synthesized in mitochondria, and when transported into the cytosol by the mitochondrial citrate carrier-SLC25A1-encoded protein-it is cleaved into acetyl-CoA and oxaloacetate by ATP citrate lyase (ACLY).	Citric Acid	0-7	ATP citrate lyase	Homo sapiens	235-239
30050389-3	2018	Citrate is an intermediary metabolite synthesized in mitochondria, and when transported into the cytosol by the mitochondrial citrate carrier-SLC25A1-encoded protein-it is cleaved into acetyl-CoA and oxaloacetate by ATP citrate lyase (ACLY).	Citric Acid	126-133	solute carrier family 25 member 1	Homo sapiens	142-149
30050389-3	2018	Citrate is an intermediary metabolite synthesized in mitochondria, and when transported into the cytosol by the mitochondrial citrate carrier-SLC25A1-encoded protein-it is cleaved into acetyl-CoA and oxaloacetate by ATP citrate lyase (ACLY).	Citric Acid	126-133	ATP citrate lyase	Homo sapiens	216-233
30050389-3	2018	Citrate is an intermediary metabolite synthesized in mitochondria, and when transported into the cytosol by the mitochondrial citrate carrier-SLC25A1-encoded protein-it is cleaved into acetyl-CoA and oxaloacetate by ATP citrate lyase (ACLY).	Citric Acid	126-133	ATP citrate lyase	Homo sapiens	235-239
30050389-11	2018	Therefore, SLC25A1 and ACLY upregulation suggests that metabolic reprogramming in BS involves the citrate pathway dysregulation.	Citric Acid	98-105	solute carrier family 25 member 1	Homo sapiens	11-18
30050389-11	2018	Therefore, SLC25A1 and ACLY upregulation suggests that metabolic reprogramming in BS involves the citrate pathway dysregulation.	Citric Acid	98-105	ATP citrate lyase	Homo sapiens	23-27
29601126-1	2018	Malic enzyme 1 (ME1) is a multifunctional protein involved in glycolysis, the citric acid cycle, NADPH production, glutamine metabolism, and lipogenesis.	Citric Acid	78-89	malic enzyme 1	Homo sapiens	16-19
29678998-1	2018	Background Urine citrate is reabsorbed exclusively along the renal proximal tubule via the apical Na+-dicarboxylate cotransporter NaDC-1.	Citric Acid	17-24	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2	Mus musculus	130-136
29620160-9	2018	The concentrations of malic acid (P=0.015) and citric acid (P=0.008) were significantly lower in pT3-4 than in pT1-2, suggesting the downregulation of tricarboxylic acid (TCA) cycle activity in pT3-4.	Citric Acid	47-58	zinc finger protein 135	Homo sapiens	97-100
29620160-9	2018	The concentrations of malic acid (P=0.015) and citric acid (P=0.008) were significantly lower in pT3-4 than in pT1-2, suggesting the downregulation of tricarboxylic acid (TCA) cycle activity in pT3-4.	Citric Acid	47-58	zinc finger protein 77	Homo sapiens	111-114
29865145-3	2018	Here, we evaluate the internalization of citrate-coated PtNPs into THP-1 monocytes and its consequences on immune cell responses.	Citric Acid	41-48	GLI family zinc finger 2	Homo sapiens	67-72
29737327-0	2018	Interference of citrate-stabilized gold nanoparticles with beta2-microglobulin oligomeric association.	Citric Acid	16-23	beta-2-microglobulin	Homo sapiens	59-78
29928345-3	2018	The mitochondrial pyruvate carrier 1 (MPC1) is involved in transporting pyruvate for entry into the citric acid cycle, an important event in cancer progression.	Citric Acid	100-111	mitochondrial pyruvate carrier 1-like	Gallus gallus	4-36
29928345-3	2018	The mitochondrial pyruvate carrier 1 (MPC1) is involved in transporting pyruvate for entry into the citric acid cycle, an important event in cancer progression.	Citric Acid	100-111	mitochondrial pyruvate carrier 1-like	Gallus gallus	38-42
29888201-0	2018	The Mitochondrial Citrate Carrier (SLC25A1) Sustains Redox Homeostasis and Mitochondrial Metabolism Supporting Radioresistance of Cancer Cells With Tolerance to Cycling Severe Hypoxia.	Citric Acid	18-25	solute carrier family 25 member 1	Homo sapiens	35-42
29888201-4	2018	Here, we explored the role of the mitochondrial citrate carrier (SLC25A1) for the improved antioxidant defense of cancer cells with tolerance to acute and chronic severe hypoxia/reoxygenation stress and the use of pharmacologic SLC25A1 inhibition for tumor cell radiosensitization.	Citric Acid	48-55	solute carrier family 25 member 1	Homo sapiens	65-72
29888201-4	2018	Here, we explored the role of the mitochondrial citrate carrier (SLC25A1) for the improved antioxidant defense of cancer cells with tolerance to acute and chronic severe hypoxia/reoxygenation stress and the use of pharmacologic SLC25A1 inhibition for tumor cell radiosensitization.	Citric Acid	48-55	solute carrier family 25 member 1	Homo sapiens	228-235
29737327-2	2018	NMR and QCMD experiments allowed us to establish that the interaction between citrate-stabilized gold nanoparticles and a paradigmatic amyloidogenic protein, beta2-microglobulin, is able to interfere with protein association into oligomers.	Citric Acid	78-85	beta-2-microglobulin	Homo sapiens	158-177
29928578-10	2018	Taken together, we suggest that inhibition of the DNL pathway following reduction in citrate levels is an important regulator of apoptosis in HepG2 cells via suppression of CPT-1 activity.	Citric Acid	85-92	carnitine palmitoyltransferase 1A	Homo sapiens	173-178
30027060-3	2018	A metabolomics analysis of cells exposed to nanosilver (nAg) integrates volcano plots (t-tests and fold change analysis), partial least squares-discriminant analysis (PLS-DA), and significance analysis of microarrays (SAM) and identifies six metabolites (l-aspartic acid, l-malic acid, myoinositol, d-sorbitol, citric acid, and l-cysteine).	Citric Acid	311-322	NBAS subunit of NRZ tethering complex	Homo sapiens	56-59
29642579-2	2018	AHAs including glycolic acid, lactic acid, malic acid, tartaric acid, and citric acid are often used extensively in cosmetic formulations.	Citric Acid	74-85	ilvB acetolactate synthase like	Homo sapiens	0-4
29857814-3	2018	HIF1, a major hypoxia induced transcription factor, promotes a dissociation between glycolysis and the tricarboxylic acid cycle, a process limiting the efficient production of ATP and citrate which otherwise would arrest glycolysis.	Citric Acid	184-191	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-4
29407868-1	2018	Binary complexes of citric acid (H3L - protonated form, H2L and HL - partly protonated forms, L - fully deprotonated) with d- and f-electron metal ions were investigated.	Citric Acid	20-31	H3 clustered histone 2	Homo sapiens	33-36
29576065-3	2018	Citrate is a primary iron chelator, and the transporter FERRIC REDUCTASE DEFECTIVE 3 (FRD3) loads citrate into the xylem.	Citric Acid	98-105	MATE efflux family protein	Arabidopsis thaliana	86-90
29594675-0	2018	The mechanism of the adsorption of dsDNA on citrate-stabilized gold nanoparticles and a colorimetric and visual method for detecting the V600E point mutation of the BRAF gene.	Citric Acid	44-51	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	165-169
29720324-6	2018	SnF2 application of ameliorated acid induced permeability in citric and hydrochloric treated samples.	Citric Acid	61-67	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	0-4
29367340-3	2018	tdt knockout plants showed decreased malate and increased citrate concentrations in leaves during the diurnal light-dark rhythm and after onset of drought, when compared with wildtypes.	Citric Acid	58-65	tonoplast dicarboxylate transporter	Arabidopsis thaliana	0-3
29367340-4	2018	Interestingly, under the latter two conditions, tDT overexpressors exhibited malate and citrate levels opposite to tdt knockout plants.	Citric Acid	88-95	tonoplast dicarboxylate transporter	Arabidopsis thaliana	48-51
29367340-5	2018	Highly purified tDT protein transports malate and citrate in a 1:1 antiport mode.	Citric Acid	50-57	tonoplast dicarboxylate transporter	Arabidopsis thaliana	16-19
29367340-10	2018	The displayed, so far unknown counterexchange properties of tDT now explain the frequently observed reciprocal concentration changes of malate and citrate in leaves from various plant species.	Citric Acid	147-154	tonoplast dicarboxylate transporter	Arabidopsis thaliana	60-63
29469914-0	2018	Citrate stabilized gold nanoparticles interfere with amyloid fibril formation: D76N and DeltaN6 beta2-microglobulin variants.	Citric Acid	0-7	beta-2-microglobulin	Homo sapiens	96-115
29469914-4	2018	In particular citrate-coated gold nanoparticles (cit-AuNPs) were recently investigated with amyloidogenic protein beta2-microglobulin (beta2m).	Citric Acid	14-21	beta-2-microglobulin	Homo sapiens	114-133
29469914-4	2018	In particular citrate-coated gold nanoparticles (cit-AuNPs) were recently investigated with amyloidogenic protein beta2-microglobulin (beta2m).	Citric Acid	14-21	beta-2-microglobulin	Homo sapiens	135-141
29686934-4	2018	For extraction, 1000 mL of sample containing 2.0% (v/v) ethanol and 0.002 mol L-1 citric acid at pH 2.50 was loaded through a 1000 mg of C18 cartridge.	Citric Acid	82-93	immunoglobulin kappa variable 1-16	Homo sapiens	78-81
29440644-4	2018	Finally, by mixing citrate-capped AuNP/probe and polyethylenimine-capped AuNP/miR-155, hybridization occurs and the optical signal of the mixture give a measure to quantify the miR-155 content.	Citric Acid	19-26	microRNA 155	Homo sapiens	177-184
29238895-2	2018	Autosomal recessive mutations in the SLC25A1 gene, which encodes the mitochondrial citrate carrier (CIC), were previously detected in patients affected with combined D/L-2-HGA.	Citric Acid	83-90	solute carrier family 25 member 1	Homo sapiens	37-44
29238895-2	2018	Autosomal recessive mutations in the SLC25A1 gene, which encodes the mitochondrial citrate carrier (CIC), were previously detected in patients affected with combined D/L-2-HGA.	Citric Acid	83-90	L-2-hydroxyglutarate dehydrogenase	Homo sapiens	168-175
29238895-3	2018	We showed that transfection of deficient fibroblasts with wild-type SLC25A1 restored citrate efflux and decreased intracellular 2-hydroxyglutarate levels, confirming that deficient CIC is the cause of D/L-2-HGA.	Citric Acid	85-92	solute carrier family 25 member 1	Homo sapiens	68-75
29973023-16	2018	Fibrinogen of patients in citrate group after CBP treatment was (3.5+-0.6) g/L, significantly higher than (3.0+-0.6) g/L in heparin group (t=-2.427, P&lt;0.05).	Citric Acid	26-33	fibrinogen beta chain	Homo sapiens	0-10
29973023-17	2018	Serum procalcitonin and CRP of patients in citrate group after CBP treatment were significantly lower than those in heparin group (t=2.520, 2.710, P&lt;0.05).	Citric Acid	43-50	C-reactive protein	Homo sapiens	24-27
29973023-18	2018	Decreased degree of serum procalcitonin and CRP of patients in citrate group after CBP treatment were (1.8+-0.6) ng/mL and (143+-69) mg/L, respectively, significantly higher than (0.9+-0.6) ng/mL and (95+-50) mg/L in heparin group (t=-4.033, -2.170, P&lt;0.05 or P&lt;0.01).	Citric Acid	63-70	C-reactive protein	Homo sapiens	44-47
29410496-1	2018	NaCT is a Na+-coupled transporter for citrate expressed in hepatocytes and neurons.	Citric Acid	38-45	solute carrier family 13 member 5	Homo sapiens	0-4
29410496-11	2018	The functional features of this citrate transport system distinguish it from NaCT.	Citric Acid	32-39	solute carrier family 13 member 5	Homo sapiens	77-81
29410496-12	2018	Loss-of-function mutations in NaCT cause early-onset epilepsy and encephalopathy; the newly discovered Na+-coupled Fe3+-citrate transport system might offer a novel treatment strategy for these patients to deliver citrate into affected neurons independent of NaCT.	Citric Acid	120-127	solute carrier family 13 member 5	Homo sapiens	30-34
29410496-12	2018	Loss-of-function mutations in NaCT cause early-onset epilepsy and encephalopathy; the newly discovered Na+-coupled Fe3+-citrate transport system might offer a novel treatment strategy for these patients to deliver citrate into affected neurons independent of NaCT.	Citric Acid	120-127	solute carrier family 13 member 5	Homo sapiens	259-263
29744439-7	2018	Furthermore, osteogenic differentiation of hMSCs exposure to Citrate resulted in less inhibitory effect on alkaline phosphatase (ALP) production.	Citric Acid	61-68	alkaline phosphatase, placental	Homo sapiens	107-127
29744439-7	2018	Furthermore, osteogenic differentiation of hMSCs exposure to Citrate resulted in less inhibitory effect on alkaline phosphatase (ALP) production.	Citric Acid	61-68	alkaline phosphatase, placental	Homo sapiens	129-132
29226520-2	2018	SLC25A1 encodes the mitochondrial citrate carrier (CIC), which mediates efflux of the mitochondrial tricarboxylic acid (TCA) cycle intermediates citrate and isocitrate in exchange for cytosolic malate.	Citric Acid	34-41	solute carrier family 25 member 1	Homo sapiens	0-7
29226520-2	2018	SLC25A1 encodes the mitochondrial citrate carrier (CIC), which mediates efflux of the mitochondrial tricarboxylic acid (TCA) cycle intermediates citrate and isocitrate in exchange for cytosolic malate.	Citric Acid	145-152	solute carrier family 25 member 1	Homo sapiens	0-7
28407230-3	2018	ATP citrate lyase (ACLY) catalyzes the conversion of citrate and coenzyme A to acetyl-CoA, hence, it is also important for lipogenesis.	Citric Acid	4-11	ATP-citrate synthase	Capra hircus	19-23
29070651-1	2018	Succinate dehydrogenase (SDH) is a heterotetrameric nuclear encoded mitochondrial protein complex which plays a role in the citric acid cycle and the electron transfer chain.	Citric Acid	124-135	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	0-23
29070651-1	2018	Succinate dehydrogenase (SDH) is a heterotetrameric nuclear encoded mitochondrial protein complex which plays a role in the citric acid cycle and the electron transfer chain.	Citric Acid	124-135	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	25-28
29275047-3	2018	METHODS: DM1 was induced by injecting STZ (diluted in citrate buffer) at a dose of 50 mg/kg intraperitoneally over 2 consecutive days into ovariectomized Wistar rats.	Citric Acid	54-61	immunoglobulin heavy diversity 1-7	Homo sapiens	9-12
29227471-5	2018	Inhibition of Mir1 by ML316 in respiring yeast diminished mitochondrial oxygen consumption, resulting in an unusual metabolic catastrophe marked by citrate accumulation and death.	Citric Acid	148-155	Mir1p	Saccharomyces cerevisiae S288C	14-18
29721422-0	2018	Runx2/Osterix and Zinc Uptake Synergize to Orchestrate Osteogenic Differentiation and Citrate Containing Bone Apatite Formation.	Citric Acid	86-93	RUNX family transcription factor 2	Homo sapiens	0-5
29721422-0	2018	Runx2/Osterix and Zinc Uptake Synergize to Orchestrate Osteogenic Differentiation and Citrate Containing Bone Apatite Formation.	Citric Acid	86-93	Sp7 transcription factor	Homo sapiens	6-13
29721422-4	2018	Moreover, zinc (Zn2+) is identified playing dual functions: (i) Zn2+ influx is influenced by ZIP1 which is regulated by Runx2 and Osterix to form a zinc-Runx2/Osterix-ZIP1 regulation axis promoting osteogenic differentiation; (ii) Zn2+ enhances citrate accumulation and deposition in bone apatite.	Citric Acid	245-252	solute carrier family 39 member 1	Homo sapiens	93-97
29721422-4	2018	Moreover, zinc (Zn2+) is identified playing dual functions: (i) Zn2+ influx is influenced by ZIP1 which is regulated by Runx2 and Osterix to form a zinc-Runx2/Osterix-ZIP1 regulation axis promoting osteogenic differentiation; (ii) Zn2+ enhances citrate accumulation and deposition in bone apatite.	Citric Acid	245-252	RUNX family transcription factor 2	Homo sapiens	120-125
29721422-4	2018	Moreover, zinc (Zn2+) is identified playing dual functions: (i) Zn2+ influx is influenced by ZIP1 which is regulated by Runx2 and Osterix to form a zinc-Runx2/Osterix-ZIP1 regulation axis promoting osteogenic differentiation; (ii) Zn2+ enhances citrate accumulation and deposition in bone apatite.	Citric Acid	245-252	Sp7 transcription factor	Homo sapiens	130-137
29721422-4	2018	Moreover, zinc (Zn2+) is identified playing dual functions: (i) Zn2+ influx is influenced by ZIP1 which is regulated by Runx2 and Osterix to form a zinc-Runx2/Osterix-ZIP1 regulation axis promoting osteogenic differentiation; (ii) Zn2+ enhances citrate accumulation and deposition in bone apatite.	Citric Acid	245-252	RUNX family transcription factor 2	Homo sapiens	153-158
29721422-4	2018	Moreover, zinc (Zn2+) is identified playing dual functions: (i) Zn2+ influx is influenced by ZIP1 which is regulated by Runx2 and Osterix to form a zinc-Runx2/Osterix-ZIP1 regulation axis promoting osteogenic differentiation; (ii) Zn2+ enhances citrate accumulation and deposition in bone apatite.	Citric Acid	245-252	Sp7 transcription factor	Homo sapiens	159-166
29222329-5	2018	Increases in the steady-state concentrations of TCA cycle metabolites including alpha-KG, succinate, fumarate, malate, and citrate were observed in TGF-beta1-differentiated myofibroblasts.	Citric Acid	123-130	transforming growth factor beta 1	Homo sapiens	148-157
29293394-1	2018	In Arabidopsis, aluminum (Al) exclusion from the root is mainly facilitated by Al-activated root malate and citrate exudation through the ALMT1 malate transporter and the MATE citrate transporter, respectively.	Citric Acid	108-115	aluminum-activated malate transporter 1	Arabidopsis thaliana	138-143
29478513-2	2018	Although glycolysis inhibitors such as sodium fluoride (NaF) in combination with potassium oxalate (KOx) are currently used for overcoming this drawback, their efficacy for stabilizing blood glucose is seemingly limited, and probably lower than that of newer additives such as the citrate buffer.	Citric Acid	281-288	C-X-C motif chemokine ligand 8	Homo sapiens	56-59
29478513-2	2018	Although glycolysis inhibitors such as sodium fluoride (NaF) in combination with potassium oxalate (KOx) are currently used for overcoming this drawback, their efficacy for stabilizing blood glucose is seemingly limited, and probably lower than that of newer additives such as the citrate buffer.	Citric Acid	281-288	NADPH oxidase 4	Homo sapiens	100-103
29085987-7	2018	Specifically, nonequilibrium capillary electrophoresis of equilibrium mixtures (NECEEM) was employed for the determination of equilibrium and rate constants for binding between citrate-stabilized AuNPs and two model proteins, lysozyme and fibrinogen.	Citric Acid	177-184	fibrinogen beta chain	Homo sapiens	239-249
29124783-7	2018	Combined, Vav1 and Vav3 deletions decreased H3Cit response and caused a modest but significant impairment of NETosis.	Citric Acid	44-49	vav 3 oncogene	Mus musculus	19-23
29563071-7	2018	The ability of KLK6 to cleave native PFK-M and form highly active citrate-resistant 45 kDa fragments was further confirmed by enzymatic tests and SDS-PAGE.	Citric Acid	66-73	kallikrein related peptidase 6	Homo sapiens	15-19
29031613-0	2018	Pathogenic mutations of the human mitochondrial citrate carrier SLC25A1 lead to impaired citrate export required for lipid, dolichol, ubiquinone and sterol synthesis.	Citric Acid	48-55	solute carrier family 25 member 1	Homo sapiens	64-71
29031613-0	2018	Pathogenic mutations of the human mitochondrial citrate carrier SLC25A1 lead to impaired citrate export required for lipid, dolichol, ubiquinone and sterol synthesis.	Citric Acid	89-96	solute carrier family 25 member 1	Homo sapiens	64-71
29031613-1	2018	Missense mutations of the human mitochondrial citrate carrier, encoded by the SLC25A1 gene, lead to an autosomal recessive neurometabolic disorder characterised by neonatal-onset encephalopathy with severe muscular weakness, intractable seizures, respiratory distress, and lack of psychomotor development, often resulting in early death.	Citric Acid	46-53	solute carrier family 25 member 1	Homo sapiens	78-85
29207315-7	2018	The ogg1-/- mice exhibited reduced mitochondrial electron transport chain (ETC) capacity and a combined low activity of the pyruvate dehydrogenase (PDH), alluding to inefficient channeling of glycolytic products into the citric acid cycle.	Citric Acid	221-232	8-oxoguanine DNA-glycosylase 1	Mus musculus	4-8
29483823-6	2018	The serum metabonomics study showed that the LDLR-/- ,PSGL-1-/- mice had higher levels of HDL, valine, acetate, pyruvate, choline, PC, GPC and glycine, and lower levels of LDL+VLDL and lactate at the early stage of atherosclerosis, while lactate, citrate and glutamine showed statistical significance at the late stage of atherosclerosis.	Citric Acid	247-254	low density lipoprotein receptor	Mus musculus	45-49
29483823-6	2018	The serum metabonomics study showed that the LDLR-/- ,PSGL-1-/- mice had higher levels of HDL, valine, acetate, pyruvate, choline, PC, GPC and glycine, and lower levels of LDL+VLDL and lactate at the early stage of atherosclerosis, while lactate, citrate and glutamine showed statistical significance at the late stage of atherosclerosis.	Citric Acid	247-254	selectin, platelet (p-selectin) ligand	Mus musculus	54-60
28741793-6	2018	Upon high-fat diet, Tert-/- hepatocytes fail to engage the citric acid cycle (TCA), with an imbalance of NADPH/NADP+ and NADH/NAD+ ratios and depletion of intermediates of TCA cycle, such as cis-aconitic acid.	Citric Acid	59-70	telomerase reverse transcriptase	Mus musculus	20-24
29318542-1	2018	Mitochondrial aconitase is a reversible enzyme that catalyzes the conversion of citrate to isocitrate in the tricarboxylic acid cycle.	Citric Acid	80-87	aconitase 2	Homo sapiens	0-23
29220362-8	2017	Whereas ACD was similar effective as CTAD, citrate only showed comparable PF4 plasma levels when plasma was kept at 4 C. Moreover, blood sampling with CTAD as anticoagulant resulted in the most reproducible values, even when samples were processed at ambient temperature or after storage over 6 hours.	Citric Acid	43-50	platelet factor 4	Homo sapiens	74-77
29124783-7	2018	Combined, Vav1 and Vav3 deletions decreased H3Cit response and caused a modest but significant impairment of NETosis.	Citric Acid	44-49	vav 1 oncogene	Mus musculus	10-14
29404068-1	2017	In this work a new method is presented for simultaneous colorimetric determination of morphine(MOR) and ibuprofen(IBU) based on the aggregation of citrate-capped gold nanoparticles (AuNPs).	Citric Acid	147-154	opioid receptor mu 1	Homo sapiens	95-98
29226743-2	2017	In the crystal structure of the tetrameric fumarase, it was found that some of the active site residues S145, T147, N188 G364 and H235 had water-mediated hydrogen bonding interactions with pyromellitic acid and citrate which help to the protonation state for the conversion of fumarate to malate.	Citric Acid	211-218	fumarate hydratase	Homo sapiens	43-51
28750242-5	2017	For serum albumin solutions prepared using citrate buffer at acidic pH, we observed a discrepancy between the experimental rotational diffusivity and that predicted from the Stokes-Einstein relation.	Citric Acid	43-50	albumin	Homo sapiens	4-17
29128444-8	2017	We observed increased urine citrate excretion (+74%, p=0.00009) and plasma 2-oxoglutarate concentrations (+12%, p=0.002) in CKD patients during treatment with a vitamin-D receptor agonist in a randomized trial.	Citric Acid	28-35	vitamin D receptor	Homo sapiens	161-179
28869274-5	2017	Two major binding sites in beta-LG were identified as being driven by citrate-mediated electrostatic interactions, while the associated binding kinetics and conformational changes in the secondary structures were also characterized.	Citric Acid	70-77	beta-lactoglobulin	Bos taurus	27-34
29045980-7	2017	After the recurrent episode of AAV was diagnosed, she underwent the following therapy: Plasmapheresis was initiated within 24 h after admission, 3 000 mL of plasma was removed per session, and the anticoagulation of citrate was applied during plasmapheresis.	Citric Acid	216-223	adeno-associated virus integration site 1	Homo sapiens	31-34
29126301-8	2017	The extrinsic pathway is triggered when tissue factor, phospholipid and calcium are added to plasma anticoagulated with citrate.	Citric Acid	120-127	coagulation factor III, tissue factor	Homo sapiens	40-53
29079735-6	2017	In our study cohort, where metabolic information was available, SFRP4 expression correlated significantly with the concentrations of citrate and spermine, two previously suggested biomarkers for aggressive prostate cancer.	Citric Acid	133-140	secreted frizzled related protein 4	Homo sapiens	64-69
28622550-12	2017	When EGCG and CHX-treated AEPs were challenged with citric acid, there was increase in cystatins and Profilin-1.	Citric Acid	52-63	profilin 1	Homo sapiens	101-111
28614745-7	2017	The predicted Y1 and Y2 were 71.07% and 0.0098 H K$/%/m3, respectively, suggesting that RSM can be readily used to determine the optimum condition of the Fe(II)/citrate/UV/PMS process for CBZ degradation.	Citric Acid	161-168	RNA, Ro60-associated Y1	Homo sapiens	14-23
28966666-7	2017	Other DEGs were enriched in the citrate cycle (tricarboxylic acid cycle; IDH1 and IDH3A) and certain DEGs were enriched in pyrimidine metabolism, including CARD8.	Citric Acid	32-39	isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha	Homo sapiens	82-87
29046123-10	2017	In summary, citrate-coated AgNPs are genotoxic in both genotypes and Ogg1 deficiency exacerbates the effect.	Citric Acid	12-19	8-oxoguanine DNA-glycosylase 1	Mus musculus	69-73
28947800-4	2017	The increase of H3K27 acetylation (H3K27ac) is dependent on adenosine triphosphate (ATP)-citrate lyase which cleaves citrate to acetyl-CoA in the cytoplasm, and requires histone acetyltransferase GCN5.	Citric Acid	89-96	histone acetyltransferase of the GNAT family 1	Arabidopsis thaliana	196-200
27856334-1	2017	The mitochondrial citrate transport protein (CTP), encoded by SLC25A1, accommodates bidirectional trafficking of citrate between the mitochondria and cytosol, supporting lipid biosynthesis and redox homeostasis.	Citric Acid	18-25	solute carrier family 25 member 1	Homo sapiens	45-48
28605936-9	2017	Patients with any AAC showed lower 24-hour urine citrate (399 vs 593 mg/day, p &lt; 0.001) and lower 24-hour urine pH (5.862 vs 6.328, p = 0.003).	Citric Acid	49-56	glycine-N-acyltransferase	Homo sapiens	18-21
28802982-5	2017	We also verified this approach using blood, a magnesium-containing liquid supplement, and two citric acid-containing soft drinks that were contaminated with saliva stains as forensic mock samples; these samples also showed a significant reduction in salivary alpha-amylase activity.	Citric Acid	94-105	amylase alpha 1A	Homo sapiens	250-272
27856334-1	2017	The mitochondrial citrate transport protein (CTP), encoded by SLC25A1, accommodates bidirectional trafficking of citrate between the mitochondria and cytosol, supporting lipid biosynthesis and redox homeostasis.	Citric Acid	18-25	solute carrier family 25 member 1	Homo sapiens	62-69
28592703-5	2017	In patients with castration-resistant prostate cancer, analysis of cfDNA revealed that all patients with 68Ga-citrate avid tumors had a gain of at least one MYC copy number.	Citric Acid	110-117	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	157-160
28592703-8	2017	A larger prospective study is ongoing to demonstrate the specificity of 68Ga-citrate for tumors with hyperactive MYC.Implications: Noninvasive measurement of MYC activity with quantitative imaging modalities could substantially increase our understanding of the role of MYC signaling in clinical settings for which invasive techniques are challenging to implement or do not characterize the biology of all tumors in a patient.	Citric Acid	77-84	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	113-116
28592703-4	2017	Importantly, 68Ga-citrate detected human prostate cancer models in a MYC-dependent fashion.	Citric Acid	18-25	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	69-72
28592703-8	2017	A larger prospective study is ongoing to demonstrate the specificity of 68Ga-citrate for tumors with hyperactive MYC.Implications: Noninvasive measurement of MYC activity with quantitative imaging modalities could substantially increase our understanding of the role of MYC signaling in clinical settings for which invasive techniques are challenging to implement or do not characterize the biology of all tumors in a patient.	Citric Acid	77-84	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	158-161
28655760-1	2017	The solute carrier family 13 member 5 (SLC13A5), a sodium-coupled citrate transporter, plays a key role in importing citrate from the circulation into liver cells.	Citric Acid	66-73	solute carrier family 13 member 5	Homo sapiens	4-37
28655760-1	2017	The solute carrier family 13 member 5 (SLC13A5), a sodium-coupled citrate transporter, plays a key role in importing citrate from the circulation into liver cells.	Citric Acid	66-73	solute carrier family 13 member 5	Homo sapiens	39-46
28655760-7	2017	Metabolically, knockdown of SLC13A5 in HepG2 and Huh7 cells was associated with a decrease in intracellular levels of citrate, the ratio of ATP/ADP, phospholipid content, and ATP citrate lyase expression.	Citric Acid	118-125	solute carrier family 13 member 5	Homo sapiens	28-35
28785759-3	2017	Here we investigated the interaction of 23 nm citrate-coated CaF2 NP with a calcium sensor protein GCAP1 that is normally expressed in photoreceptor cells and involved in the regulation of the early steps of vision.	Citric Acid	46-53	CCR4-NOT transcription complex subunit 8	Homo sapiens	61-65
28821606-2	2017	A new study reports that loss of solute carrier family 13 member 5, which transports citrate across cell membranes, halts liver cancer cell growth by altering both energy production and mammalian target of rapamycin signaling in human liver cancer cell lines and in both an in vitro and in vivo model of liver tumors, suggesting a new target for liver cancer chemoprevention and/or chemotherapy.	Citric Acid	85-92	solute carrier family 13 member 5	Homo sapiens	33-66
28821606-2	2017	A new study reports that loss of solute carrier family 13 member 5, which transports citrate across cell membranes, halts liver cancer cell growth by altering both energy production and mammalian target of rapamycin signaling in human liver cancer cell lines and in both an in vitro and in vivo model of liver tumors, suggesting a new target for liver cancer chemoprevention and/or chemotherapy.	Citric Acid	85-92	mechanistic target of rapamycin kinase	Homo sapiens	186-215
28785759-3	2017	Here we investigated the interaction of 23 nm citrate-coated CaF2 NP with a calcium sensor protein GCAP1 that is normally expressed in photoreceptor cells and involved in the regulation of the early steps of vision.	Citric Acid	46-53	guanylate cyclase activator 1A	Homo sapiens	99-104
28551574-6	2017	Citrate-stabilized nanoparticles (SBTC) induced superoxide dismutase (SOD) activity in the HL-60 cells and total antioxidant activity in the U-937 cells despite their resistance to oxidative dissolution.	Citric Acid	0-7	superoxide dismutase 1	Homo sapiens	48-68
28133767-9	2017	Activation of the IL-6-signal transducer and activator of transcription 3 pathway stimulated mIndy expression, enhanced cytoplasmic citrate influx, and augmented hepatic lipogenesis in vivo.	Citric Acid	132-139	interleukin 6	Homo sapiens	18-22
28133767-9	2017	Activation of the IL-6-signal transducer and activator of transcription 3 pathway stimulated mIndy expression, enhanced cytoplasmic citrate influx, and augmented hepatic lipogenesis in vivo.	Citric Acid	132-139	signal transducer and activator of transcription 3	Homo sapiens	23-73
28133767-10	2017	In contrast, deletion of mIndy completely prevented the stimulating effect of IL-6 on citrate uptake and reduced hepatic lipogenesis.	Citric Acid	86-93	solute carrier family 13 (sodium-dependent citrate transporter), member 5	Mus musculus	25-30
28133767-10	2017	In contrast, deletion of mIndy completely prevented the stimulating effect of IL-6 on citrate uptake and reduced hepatic lipogenesis.	Citric Acid	86-93	interleukin 6	Homo sapiens	78-82
28322955-3	2017	However, the presence of citrate resulted in autoproteolysis of pro-caspase-9 and its inhibition by XIAP BIR3, which was not observed for apoptosome activated pro-caspase-9 indicating abnormal behavior of pro-caspase-9 in kosmotropic citrate salt.	Citric Acid	25-32	caspase 9	Homo sapiens	68-77
28322955-3	2017	However, the presence of citrate resulted in autoproteolysis of pro-caspase-9 and its inhibition by XIAP BIR3, which was not observed for apoptosome activated pro-caspase-9 indicating abnormal behavior of pro-caspase-9 in kosmotropic citrate salt.	Citric Acid	25-32	X-linked inhibitor of apoptosis	Homo sapiens	100-104
28585096-0	2017	Cellular citrate levels establish a regulatory link between energy metabolism and the hepatic iron hormone hepcidin.	Citric Acid	9-16	hepcidin antimicrobial peptide	Mus musculus	107-115
28585096-4	2017	We show that the inhibition of citrate-consuming enzymes increases hepcidin mRNA expression in primary murine hepatocytes.	Citric Acid	31-38	hepcidin antimicrobial peptide	Mus musculus	67-75
28585096-5	2017	Consistently, citrate treatment of primary murine hepatocytes or intravenous injection of citrate in mice increases cellular citrate concentrations and hepcidin expression.	Citric Acid	14-21	hepcidin antimicrobial peptide	Mus musculus	152-160
28585096-5	2017	Consistently, citrate treatment of primary murine hepatocytes or intravenous injection of citrate in mice increases cellular citrate concentrations and hepcidin expression.	Citric Acid	90-97	hepcidin antimicrobial peptide	Mus musculus	152-160
28585096-5	2017	Consistently, citrate treatment of primary murine hepatocytes or intravenous injection of citrate in mice increases cellular citrate concentrations and hepcidin expression.	Citric Acid	90-97	hepcidin antimicrobial peptide	Mus musculus	152-160
28585096-6	2017	We further demonstrate that the hepcidin response to citrate involves the SMAD signaling pathway.	Citric Acid	53-60	hepcidin antimicrobial peptide	Mus musculus	32-40
28585096-8	2017	KEY MESSAGES:   Elevated citrate levels increase hepcidin mRNA expression in primary hepatocytes.	Citric Acid	25-32	hepcidin antimicrobial peptide	Mus musculus	49-57
28585096-9	2017	Citrate treatment in primary hepatocytes activates hepcidin expression.	Citric Acid	0-7	hepcidin antimicrobial peptide	Mus musculus	51-59
28585096-10	2017	Intravenous injection of citrate in mice increases hepcidin mRNA levels.	Citric Acid	25-32	hepcidin antimicrobial peptide	Mus musculus	51-59
28585096-11	2017	The hepcidin response to citrate involves the BMP/SMAD signaling pathway.	Citric Acid	25-32	hepcidin antimicrobial peptide	Mus musculus	4-12
28673551-3	2017	RESULTS: Distinctive elevations of citrate and dysregulation of citric acid cycle intermediates, supporting the hypothesis that loss of SLC13A5 function alters tricarboxylic acid cycle (TCA) metabolism and may disrupt metabolic compartmentation in the brain.	Citric Acid	35-42	solute carrier family 13 member 5	Homo sapiens	136-143
28673551-3	2017	RESULTS: Distinctive elevations of citrate and dysregulation of citric acid cycle intermediates, supporting the hypothesis that loss of SLC13A5 function alters tricarboxylic acid cycle (TCA) metabolism and may disrupt metabolic compartmentation in the brain.	Citric Acid	64-75	solute carrier family 13 member 5	Homo sapiens	136-143
28673551-4	2017	SIGNIFICANCE: Our results indicate that analysis of plasma citrate and other TCA analytes in SLC13A5 deficient patients define a diagnostic metabolic signature that can aid in diagnosing children with this disease.	Citric Acid	59-66	solute carrier family 13 member 5	Homo sapiens	93-100
29404483-7	2017	Among these, adipose tissue insulin sensitivity assessed by clamped percent suppression of free fatty acid, serum high molecular weight adiponectin, and plasma tricarboxylic acid cycle metabolites, such as citric acid and cis-aconitic acid, were significantly higher in the high-HIS group compared to the low-HIS group.	Citric Acid	206-217	insulin	Homo sapiens	28-35
28747166-3	2017	It is caused by mutations in the FH gene (1q42.1) that result in deficiency of the citric acid cycle enzyme fumarate hydratase, resulting in accumulation of fumaric acid.	Citric Acid	83-89	fumarate hydratase	Homo sapiens	33-35
28747166-3	2017	It is caused by mutations in the FH gene (1q42.1) that result in deficiency of the citric acid cycle enzyme fumarate hydratase, resulting in accumulation of fumaric acid.	Citric Acid	83-89	fumarate hydratase	Homo sapiens	108-126
28723962-6	2017	The kinetics data of thrombin generation showed that ZnO NPs reduced the thrombin generation potential with functionalization-specificity in the order of pristine &gt; citrate &gt; L-serine but there was no size-specificity.	Citric Acid	168-175	coagulation factor II	Rattus norvegicus	73-81
28551574-6	2017	Citrate-stabilized nanoparticles (SBTC) induced superoxide dismutase (SOD) activity in the HL-60 cells and total antioxidant activity in the U-937 cells despite their resistance to oxidative dissolution.	Citric Acid	0-7	superoxide dismutase 1	Homo sapiens	70-73
28671531-6	2017	However, ACE did not use aromatic compounds and was unable to grow on common carbon sources, such as glucose, xylose, glycerol or citrate.	Citric Acid	130-137	angiotensin I converting enzyme	Homo sapiens	9-12
28644630-1	2017	The recent X-ray structure of titanium(IV)-bound human serum transferrin (STf) exhibiting citrate as a synergistic anion reveals a difference in Ti(IV) coordination versus iron(III), the metal endogenously delivered by the protein to cells.	Citric Acid	90-97	transferrin	Homo sapiens	61-72
28674429-0	2017	Citrate Suppresses Tumor Growth in Multiple Models through Inhibition of Glycolysis, the Tricarboxylic Acid Cycle and the IGF-1R Pathway.	Citric Acid	0-7	insulin like growth factor 1 receptor	Homo sapiens	122-128
28674429-6	2017	Moreover, we found that citrate inhibited IGF-1R phosphorylation.	Citric Acid	24-31	insulin like growth factor 1 receptor	Homo sapiens	42-48
28674429-7	2017	In vitro studies suggested that citrate treatment inhibited AKT phosphorylation, activated PTEN and increased expression of p-eIF2a.	Citric Acid	32-39	phosphatase and tensin homolog	Homo sapiens	91-95
28674429-7	2017	In vitro studies suggested that citrate treatment inhibited AKT phosphorylation, activated PTEN and increased expression of p-eIF2a.	Citric Acid	32-39	eukaryotic translation initiation factor 2 subunit alpha	Homo sapiens	126-131
28674429-9	2017	These data suggest that citrate acts on the IGF-1R-AKT-PTEN-eIF2a pathway.	Citric Acid	24-31	insulin like growth factor 1 receptor	Homo sapiens	44-50
28674429-9	2017	These data suggest that citrate acts on the IGF-1R-AKT-PTEN-eIF2a pathway.	Citric Acid	24-31	phosphatase and tensin homolog	Homo sapiens	55-59
28674429-9	2017	These data suggest that citrate acts on the IGF-1R-AKT-PTEN-eIF2a pathway.	Citric Acid	24-31	eukaryotic translation initiation factor 2 subunit alpha	Homo sapiens	60-65
28166201-4	2017	PCK2 downregulation accelerated biosynthesis and transportation of citrate from mitochondria to the cytosol, leading to cytosolic glucose carbon flow via OAA-malate-pyruvate and acetyl-CoA-fatty acid pathways in TRCs.	Citric Acid	67-74	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	0-4
27829555-1	2017	Zwitterionic peptides were anchored to a conducting polymer of citrate doped poly(3,4-ethylenedioxythiophene) (PEDOT) via the nickel cation coordination, and the obtained peptide modified PEDOT, with excellent antifouling ability and good conductivity, was further used for the immobilization of a DNA probe to construct an electrochemical biosensor for the breast cancer marker BRCA1.	Citric Acid	63-70	BRCA1 DNA repair associated	Homo sapiens	379-384
28462819-4	2017	Here, we identified that WNT7B and WNT8B secreted from hepatocytes and cholangiocytes play important roles in achieving perivenous zone-specific characteristics, such as the enhancement of glutamine secretion, citric acid cycle, cytochrome P450 (CYP) 1A2 metabolism, and CYP1A2 induction capacities.	Citric Acid	210-221	Wnt family member 7B	Homo sapiens	25-30
28462819-4	2017	Here, we identified that WNT7B and WNT8B secreted from hepatocytes and cholangiocytes play important roles in achieving perivenous zone-specific characteristics, such as the enhancement of glutamine secretion, citric acid cycle, cytochrome P450 (CYP) 1A2 metabolism, and CYP1A2 induction capacities.	Citric Acid	210-221	Wnt family member 8B	Homo sapiens	35-40
28284162-0	2017	SERS substrates fabricated using ceramic filters for the detection of bacteria: Eliminating the citrate interference.	Citric Acid	96-103	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	0-4
28284162-1	2017	It was found that spectra obtained for bacteria on SERS substrates fabricated by filtering citrate-generated Ag nanoparticles (NPs) onto rigid, ceramic filters exhibited peaks due to citrate as well as the bacteria.	Citric Acid	91-98	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	51-55
28284162-1	2017	It was found that spectra obtained for bacteria on SERS substrates fabricated by filtering citrate-generated Ag nanoparticles (NPs) onto rigid, ceramic filters exhibited peaks due to citrate as well as the bacteria.	Citric Acid	183-190	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	51-55
28265615-0	2017	Citrate-stabilized gold nanoparticles hinder fibrillogenesis of a pathological variant of beta2-microglobulin.	Citric Acid	0-7	beta-2-microglobulin	Homo sapiens	90-109
28316078-4	2017	Further, these 5-HT3 -expressing nerve fibers terminate in a restricted central-lateral portion of the nucleus of the solitary tract (nTS)-the same area that shows increased c-Fos expression upon presentation of a sour tastant (30 mM citric acid).	Citric Acid	234-245	hypothermia due to alcohol sensitivity 3	Mus musculus	17-20
28391595-4	2017	In mitochondria, it is possible that some or all of the enzymes of the citric acid cycle, including citrate synthase, are organized in metabolons to facilitate the channelling of substrates between participating enzymes.	Citric Acid	71-82	citrate synthase	Homo sapiens	100-116
28481367-3	2017	In glucose-restricted culture conditions, cancer cells increased ME1 expression, and tracer experiments with labelled glutamine revealed that the flux of ME1-derived pyruvate to citrate was enhanced.	Citric Acid	178-185	malic enzyme 1	Homo sapiens	154-157
28467904-4	2017	During this period, the inhibition of STAT3 blocks the expression of citrate synthase (CS) and reduces the levels of intracellular citrate.	Citric Acid	69-76	signal transducer and activator of transcription 3	Homo sapiens	38-43
28467904-4	2017	During this period, the inhibition of STAT3 blocks the expression of citrate synthase (CS) and reduces the levels of intracellular citrate.	Citric Acid	69-76	citrate synthase	Homo sapiens	87-89
28467904-6	2017	These effects were due to STAT3-dependent transcriptional regulation of CS, as exogenous addition of citrate could restore fatty acid synthesis, cell growth, and proliferation.	Citric Acid	101-108	signal transducer and activator of transcription 3	Homo sapiens	26-31
28467904-6	2017	These effects were due to STAT3-dependent transcriptional regulation of CS, as exogenous addition of citrate could restore fatty acid synthesis, cell growth, and proliferation.	Citric Acid	101-108	citrate synthase	Homo sapiens	72-74
28671097-1	2017	The effect of citrate to Desloratadine Citrate Disodium set in the treatment of chronic urticaria in patients with IL4, IL18, and IL23, IL33 levels was investigated.	Citric Acid	14-21	interleukin 4	Homo sapiens	115-118
28671097-1	2017	The effect of citrate to Desloratadine Citrate Disodium set in the treatment of chronic urticaria in patients with IL4, IL18, and IL23, IL33 levels was investigated.	Citric Acid	14-21	interleukin 18	Homo sapiens	120-124
28671097-1	2017	The effect of citrate to Desloratadine Citrate Disodium set in the treatment of chronic urticaria in patients with IL4, IL18, and IL23, IL33 levels was investigated.	Citric Acid	14-21	interleukin 23 subunit alpha	Homo sapiens	130-134
28671097-1	2017	The effect of citrate to Desloratadine Citrate Disodium set in the treatment of chronic urticaria in patients with IL4, IL18, and IL23, IL33 levels was investigated.	Citric Acid	14-21	interleukin 33	Homo sapiens	136-140
28370161-8	2017	Intracellular citrate concentrations were increased in red cells stored in AS-3 and PAGGSM media.	Citric Acid	14-21	PDS5 cohesin associated factor B	Homo sapiens	75-79
28059952-3	2017	RECENT FINDINGS: ACLY is a critical enzyme linking glucose catabolism to lipogenesis by providing acetyl-CoA from mitochondrial citrate for fatty acid and cholesterol biosynthesis.	Citric Acid	128-135	ATP citrate lyase	Homo sapiens	17-21
28640312-5	2017	The results suggested that Metvan transforms at physiological pH into the hydrolytic species cis-[VO(Me2phen)2(OH)]+ and that both citrate and proteins (transferrin and albumin in the blood serum, and hemoglobin in the erythrocytes) form mixed complexes, denoted [VO(Me2phen)(citrH-1)]2- and VO-Me2phen-Protein with the probable binding of His-N donors.	Citric Acid	131-138	transferrin	Homo sapiens	153-164
27639591-2	2017	The Na+-dicarboxylate cotransporter NaDC1, encoded by the sodium-dicarboxylate cotransporter (SLC13A2) gene, is a major determinant of urinary citrate excretion and its biological functions are regulated also by the vitamin D/Vitamin D receptor (VDR) biological system.	Citric Acid	143-150	solute carrier family 13 member 2	Homo sapiens	36-41
27639591-2	2017	The Na+-dicarboxylate cotransporter NaDC1, encoded by the sodium-dicarboxylate cotransporter (SLC13A2) gene, is a major determinant of urinary citrate excretion and its biological functions are regulated also by the vitamin D/Vitamin D receptor (VDR) biological system.	Citric Acid	143-150	solute carrier family 13 member 2	Homo sapiens	94-101
27639591-2	2017	The Na+-dicarboxylate cotransporter NaDC1, encoded by the sodium-dicarboxylate cotransporter (SLC13A2) gene, is a major determinant of urinary citrate excretion and its biological functions are regulated also by the vitamin D/Vitamin D receptor (VDR) biological system.	Citric Acid	143-150	vitamin D receptor	Homo sapiens	246-249
28617269-6	2017	At a low concentration of Pb(II) ions (20 mg/L), the amount of photoreduced Pb(II) ions was proportional to the concentration of the citric acid solution, but at high concentrations (240 mg/L), the correlation was inversely proportional.	Citric Acid	133-144	submaxillary gland androgen regulated protein 3B	Homo sapiens	26-32
28617269-6	2017	At a low concentration of Pb(II) ions (20 mg/L), the amount of photoreduced Pb(II) ions was proportional to the concentration of the citric acid solution, but at high concentrations (240 mg/L), the correlation was inversely proportional.	Citric Acid	133-144	submaxillary gland androgen regulated protein 3B	Homo sapiens	76-82
28596784-6	2017	The metabolic effects of reducing INDY activity are the result of reduced cytoplasmic citrate.	Citric Acid	86-93	solute carrier family 13 (sodium-dependent citrate transporter), member 5	Mus musculus	34-38
28596784-8	2017	Thereby newly described drugs that reduce INDY transporting activity increase insulin sensitivity and reduce hepatic lipid levels via its effect on hepatic citrate uptake.	Citric Acid	156-163	solute carrier family 13 (sodium-dependent citrate transporter), member 5	Mus musculus	42-46
28596784-8	2017	Thereby newly described drugs that reduce INDY transporting activity increase insulin sensitivity and reduce hepatic lipid levels via its effect on hepatic citrate uptake.	Citric Acid	156-163	insulin	Homo sapiens	78-85
28474724-2	2017	In comparison with AgNO3, in-depth investigations were carried out into the interactions between citrate-coated AgNPs (20 nm) and two metalloproteins, intracellular metallothionein 1 (MT1) and plasmatic ceruloplasmin (Cp), both involved in metal homeostasis.	Citric Acid	97-104	metallothionein 1I, pseudogene	Homo sapiens	165-182
28474724-2	2017	In comparison with AgNO3, in-depth investigations were carried out into the interactions between citrate-coated AgNPs (20 nm) and two metalloproteins, intracellular metallothionein 1 (MT1) and plasmatic ceruloplasmin (Cp), both involved in metal homeostasis.	Citric Acid	97-104	ceruloplasmin	Homo sapiens	203-216
28229947-5	2017	A proof of concept production of hydrated and anhydrous cocrystals of 1:1 Theophylline Citric acid system at a 400mg scale was demonstrated using solvent and bead assisted RAM.	Citric Acid	87-98	CCDC26 long non-coding RNA	Homo sapiens	172-175
28443281-2	2017	As part of the metabolic transformation MYC promotes lipid, nucleotide and protein synthesis by hijacking citric acid cycle to serve biosynthetic processes, which simultaneously exhausts ATP production.	Citric Acid	106-117	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	40-43
27819678-10	2017	A gene co-expression network identified using TCGA prostate tumour RNA-sequencing identifies co-regulated cancer genes associated with 2-oxoglutarate (2-OG) and succinate metabolism, including TET2, lysine demethylase (KDM) KDM6A, BRCA1-associated BAP1, and citric acid cycle enzymes IDH1/2, SDHA/B, and FH.	Citric Acid	258-269	tet methylcytosine dioxygenase 2	Homo sapiens	193-197
27819678-10	2017	A gene co-expression network identified using TCGA prostate tumour RNA-sequencing identifies co-regulated cancer genes associated with 2-oxoglutarate (2-OG) and succinate metabolism, including TET2, lysine demethylase (KDM) KDM6A, BRCA1-associated BAP1, and citric acid cycle enzymes IDH1/2, SDHA/B, and FH.	Citric Acid	258-269	lysine demethylase 6A	Homo sapiens	224-229
27819678-10	2017	A gene co-expression network identified using TCGA prostate tumour RNA-sequencing identifies co-regulated cancer genes associated with 2-oxoglutarate (2-OG) and succinate metabolism, including TET2, lysine demethylase (KDM) KDM6A, BRCA1-associated BAP1, and citric acid cycle enzymes IDH1/2, SDHA/B, and FH.	Citric Acid	258-269	BRCA1 DNA repair associated	Homo sapiens	231-236
27819678-10	2017	A gene co-expression network identified using TCGA prostate tumour RNA-sequencing identifies co-regulated cancer genes associated with 2-oxoglutarate (2-OG) and succinate metabolism, including TET2, lysine demethylase (KDM) KDM6A, BRCA1-associated BAP1, and citric acid cycle enzymes IDH1/2, SDHA/B, and FH.	Citric Acid	258-269	BRCA1 associated protein 1	Homo sapiens	248-252
27819678-10	2017	A gene co-expression network identified using TCGA prostate tumour RNA-sequencing identifies co-regulated cancer genes associated with 2-oxoglutarate (2-OG) and succinate metabolism, including TET2, lysine demethylase (KDM) KDM6A, BRCA1-associated BAP1, and citric acid cycle enzymes IDH1/2, SDHA/B, and FH.	Citric Acid	258-269	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	284-290
28189066-3	2017	Malate dehydrogenase 2 (MDH2) is one of the isoforms of malate dehydrogenase, which is involved in citric acid cycle in mitochondria.	Citric Acid	99-110	malate dehydrogenase 2	Homo sapiens	0-22
28189066-3	2017	Malate dehydrogenase 2 (MDH2) is one of the isoforms of malate dehydrogenase, which is involved in citric acid cycle in mitochondria.	Citric Acid	99-110	malate dehydrogenase 2	Homo sapiens	24-28
28189066-3	2017	Malate dehydrogenase 2 (MDH2) is one of the isoforms of malate dehydrogenase, which is involved in citric acid cycle in mitochondria.	Citric Acid	99-110	malic enzyme 1	Homo sapiens	56-76
28276241-3	2017	The insulin synthesis was markedly reduced with non-DNA citrate-capped AuNP (1.25-fold) and AuNP-DNA with a nonspecific poly(T) sequence (1.25-fold).	Citric Acid	56-63	insulin	Homo sapiens	4-11
28355564-7	2017	Inhibition of H3Cit induced H3K9me3 at the overlapping regions of H3R26Cit peaks and SMARCAD1 peaks.	Citric Acid	14-19	SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1	Homo sapiens	85-93
28110161-0	2017	Citrate and albumin facilitate transferrin iron loading in the presence of phosphate.	Citric Acid	0-7	transferrin	Homo sapiens	31-42
28110161-7	2017	In this study we evaluate iron loading into transferrin under physiologically relevant phosphate conditions to evaluate the roles of citrate and albumin in mediating iron delivery into apo transferrin.	Citric Acid	133-140	transferrin	Homo sapiens	189-200
28110161-10	2017	The results showed citrate marginally improved the delivery of Fe3+ to apo transferrin.	Citric Acid	19-26	transferrin	Homo sapiens	75-86
28110161-12	2017	The most efficient Fe3+ loading into apo transferrin in a phosphate solution occurred when both citrate and albumin were present at physiological concentrations.	Citric Acid	96-103	transferrin	Homo sapiens	41-52
28110161-13	2017	Citrate and albumin overcame phosphate inhibition and loaded apo transferrin equal to the control of Fe3+ added to apo transferrin.	Citric Acid	0-7	transferrin	Homo sapiens	65-76
28110161-14	2017	Our results suggest a physiologically important role for albumin and citrate for apo transferrin iron loading.	Citric Acid	69-76	transferrin	Homo sapiens	85-96
28184946-11	2017	There was significant correlation between [111In]TSP-A18 uptake and TfR protein expression in both strains, whereas there was significant correlation of [67Ga]citrate uptake with TfR expression only in C57BL/6J.	Citric Acid	159-166	transferrin receptor	Mus musculus	179-182
28254778-5	2017	In contrast, exogenously applied organic acids such as malate or citrate are able to reverse the stomatal closure induced by MPK3/MPK6 activation.	Citric Acid	65-72	mitogen-activated protein kinase 3	Arabidopsis thaliana	125-129
28254778-5	2017	In contrast, exogenously applied organic acids such as malate or citrate are able to reverse the stomatal closure induced by MPK3/MPK6 activation.	Citric Acid	65-72	MAP kinase 6	Arabidopsis thaliana	130-134
28078343-3	2017	Both citrate- and branched polyethyleneimine-coated AgNPs (c-AgNPs, bPEI-AgNPs) inhibited IAPP aggregation at 500 mug mL-1, likely through electrostatic attraction and sequestering of IAPP monomers from fibrillation.	Citric Acid	5-12	islet amyloid polypeptide	Homo sapiens	90-94
28030815-9	2017	The NCWP-EMT signature was also associated with decreased concentrations of the metabolites citrate and spermine, which have previously been linked to aggressive prostate cancer.	Citric Acid	92-99	IL2 inducible T cell kinase	Homo sapiens	9-12
28260837-2	2017	In this work, we systematically explored the interactions between citrate-capped gold nanoparticles (AuNPs) and islet amyloid polypeptide (IAPP), a 37-amino acid peptide hormone co-secreted with insulin from the pancreatic islet.	Citric Acid	66-73	islet amyloid polypeptide	Homo sapiens	139-143
28260837-2	2017	In this work, we systematically explored the interactions between citrate-capped gold nanoparticles (AuNPs) and islet amyloid polypeptide (IAPP), a 37-amino acid peptide hormone co-secreted with insulin from the pancreatic islet.	Citric Acid	66-73	insulin	Homo sapiens	195-202
28260837-7	2017	On a Au(111) surface, IAPP was unfolded and adsorbed directly onto the Au surface, while for the Au(100) surface, it interacted predominantly with the citrate adlayer and retained some helical conformation.	Citric Acid	151-158	islet amyloid polypeptide	Homo sapiens	22-26
28264506-1	2017	SLC13A5 is a Na+-coupled transporter for citrate that is expressed in the plasma membrane of specific cell types in the liver, testis, and brain.	Citric Acid	41-48	solute carrier family 13 member 5	Homo sapiens	0-7
28264506-3	2017	In humans, the Michaelis constant for SLC13A5 to transport citrate is ~600 muM, which is physiologically relevant given that the normal concentration of citrate in plasma is in the range of 150-200 muM.	Citric Acid	59-66	solute carrier family 13 member 5	Homo sapiens	38-45
28264506-3	2017	In humans, the Michaelis constant for SLC13A5 to transport citrate is ~600 muM, which is physiologically relevant given that the normal concentration of citrate in plasma is in the range of 150-200 muM.	Citric Acid	153-160	solute carrier family 13 member 5	Homo sapiens	38-45
28264506-5	2017	Human SLC13A5 differs from rodent Slc13a5 in two important aspects: the affinity of the human transporter for citrate is ~30-fold less than that of the rodent transporter, thus making human SLC13A5 a low-affinity/high-capacity transporter and the rodent Slc13a5 a high-affinity/low-capacity transporter.	Citric Acid	110-117	solute carrier family 13 member 5	Homo sapiens	6-13
28264506-5	2017	Human SLC13A5 differs from rodent Slc13a5 in two important aspects: the affinity of the human transporter for citrate is ~30-fold less than that of the rodent transporter, thus making human SLC13A5 a low-affinity/high-capacity transporter and the rodent Slc13a5 a high-affinity/low-capacity transporter.	Citric Acid	110-117	solute carrier family 13 member 5	Homo sapiens	190-197
28264506-6	2017	In the liver, SLC13A5 is expressed exclusively in the sinusoidal membrane of the hepatocytes, where it plays a role in the uptake of circulating citrate from the sinusoidal blood for metabolic use.	Citric Acid	145-152	solute carrier family 13 member 5	Homo sapiens	14-21
28264506-9	2017	As astrocytes secrete citrate into extracellular medium, the potential function of SLC13A5 in neurons is to mediate the uptake of circulating citrate and astrocyte-released citrate for subsequent metabolism.	Citric Acid	22-29	solute carrier family 13 member 5	Homo sapiens	83-90
28264506-9	2017	As astrocytes secrete citrate into extracellular medium, the potential function of SLC13A5 in neurons is to mediate the uptake of circulating citrate and astrocyte-released citrate for subsequent metabolism.	Citric Acid	142-149	solute carrier family 13 member 5	Homo sapiens	83-90
28264506-9	2017	As astrocytes secrete citrate into extracellular medium, the potential function of SLC13A5 in neurons is to mediate the uptake of circulating citrate and astrocyte-released citrate for subsequent metabolism.	Citric Acid	142-149	solute carrier family 13 member 5	Homo sapiens	83-90
28167750-2	2017	In mammalian cells the central precursor for lipid biosynthesis, cytosolic acetyl CoA (Ac-CoA), is produced by ATP-citrate lyase (ACLY) from mitochondria-derived citrate or by acetyl-CoA synthetase short-chain family member 2 (ACSS2) from acetate.	Citric Acid	115-122	ATP citrate lyase	Homo sapiens	130-134
28167750-2	2017	In mammalian cells the central precursor for lipid biosynthesis, cytosolic acetyl CoA (Ac-CoA), is produced by ATP-citrate lyase (ACLY) from mitochondria-derived citrate or by acetyl-CoA synthetase short-chain family member 2 (ACSS2) from acetate.	Citric Acid	115-122	acyl-CoA synthetase short chain family member 2	Homo sapiens	227-232
28208702-4	2017	In addition, the GDH pathway is linked to diverse cellular processes, including ammonia metabolism, acid-base equilibrium, redox homeostasis (via formation of fumarate), lipid biosynthesis (via oxidative generation of citrate), and lactate production.	Citric Acid	218-225	glutamate dehydrogenase 1	Homo sapiens	17-20
28177875-6	2017	In addition, by analyzing the metabolic profiles of long-lived germline-less glp-1 mutants, we discovered that glp-1 mutants regulate the levels of many age-variant metabolites to attenuate aging, including elevated concentrations of the pyrimidine and purine metabolism intermediates and decreased concentrations of the citric acid cycle intermediates.	Citric Acid	321-332	glp-1/Notch intracellular domain	Caenorhabditis elegans	111-116
27890529-5	2017	Strong PC suppression lowered glucose incorporation into downstream metabolites of oxaloacetate, the product of the PC reaction, including malate, citrate and aspartate.	Citric Acid	147-154	pyruvate carboxylase	Homo sapiens	7-9
27890529-5	2017	Strong PC suppression lowered glucose incorporation into downstream metabolites of oxaloacetate, the product of the PC reaction, including malate, citrate and aspartate.	Citric Acid	147-154	pyruvate carboxylase	Homo sapiens	116-118
27292295-8	2017	In wild-type mice, citric acid stimulation evoked significant c-Fos activation in the central part of the rostral nTS-activity that was largely absent in the P2X-dbl KO mice.	Citric Acid	19-30	FBJ osteosarcoma oncogene	Mus musculus	62-67
27596402-5	2017	The content of citrate was significantly increased, which was primarily attributed to the inhibition of the expression of glutamate decarboxylase (GAD).	Citric Acid	15-22	glutamate-ammonia ligase	Homo sapiens	122-145
27596402-5	2017	The content of citrate was significantly increased, which was primarily attributed to the inhibition of the expression of glutamate decarboxylase (GAD).	Citric Acid	15-22	glutamate-ammonia ligase	Homo sapiens	147-150
27721426-4	2017	The IDH2 protein is localized in the mitochondria and is a critical component of the tricarboxylic acid (also called the "citric acid" or Krebs) cycle.	Citric Acid	122-133	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	4-8
27707801-5	2016	Indeed, we found that yeast cells assimilating hydroxybenzoates increase the expression of genes SFC1, LEU5, YHM2, and MPC1 coding for succinate/fumarate carrier, coenzyme A carrier, oxoglutarate/citrate carrier, and the subunit of pyruvate carrier, respectively.	Citric Acid	196-203	Sfc1p	Saccharomyces cerevisiae S288C	97-101
27871965-4	2017	In this review, we analytically summarize recent findings, which indicate that gain-of-function (GOF) mutant p53 proteins counteract the autophagic machinery by various molecular mechanisms including the regulation of AMPK and Akt/mTOR pathways, autophagy-related genes (ATGs), HIF-1alpha target genes, and the mitochondrial citrate carrier CIC.	Citric Acid	325-332	tumor protein p53	Homo sapiens	109-112
27566399-3	2017	Here, we report that (i) citric acid (0.2 mol/L) pH-dependently induced a scratching response in mice when applied intradermally to nape or cheek skin, (ii) acidified buffer elevated intracellular calcium levels in dorsal root ganglion pruriceptors, and (iii) injection of intradermal citric acid (pH 3.0) into the nape induced a pruritogen-like but not algogen-like c-Fos immunoreactivity pattern in the cervical spinal cord.	Citric Acid	25-36	FBJ osteosarcoma oncogene	Mus musculus	367-372
27566399-5	2017	Results indicate that TRPV1, but neither ASIC3 nor TRPA1, is involved in the acidic citrate-induced scratching response.	Citric Acid	84-91	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	22-27
27566399-7	2017	Itch induced by acidic citrate, but not alpha-methyl-5-hydroxytryptamine, chloroquine, compound 48/80, or bile acid, was markedly decreased in TDAG8-/- mice.	Citric Acid	23-30	G-protein coupled receptor 65	Mus musculus	143-148
29122211-8	2017	RESULTS: Unlike the citrate dialysates, the dialysates with acetate (dialysate 3 and dialysate 4) induced increased ICAM-1 expression density in THP-1 cells; an increase in ICAM-1 expression was observed in the immunocompetent cells of healthy subjects with acetate dialysate (dialysate 3 and dialysate 4) but not with citrate dialysate (dialysate 1 and dialysate 2).	Citric Acid	319-326	intercellular adhesion molecule 1	Homo sapiens	173-179
27802586-0	2017	Crystal structure of heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB2) and the inhibitory influence of citrate on substrate binding.	Citric Acid	121-128	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	Homo sapiens	81-87
27802586-3	2017	Citrate, a TCA cycle intermediate and well-known inhibitor of PFKFB2, co-crystallized in the 2-kinase domains of both orthologues, occupying the fructose-6-phosphate binding-site and extending into the gamma-phosphate binding pocket of ATP.	Citric Acid	0-7	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	Homo sapiens	62-68
27802586-9	2017	Together, these structural and kinetic data establish a molecular basis for citrate"s negative feed-back loop of the glycolytic pathway via PFKFB2.	Citric Acid	76-83	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	Homo sapiens	140-146
30404406-6	2016	In the thermal desorption spectroscopy (TDS) measurement of the H2/Ar plasma-treated Cu sample, the total number of the detected H2 was 3.1 times more than the citric acid-treated one.	Citric Acid	160-171	H2A clustered histone 19	Homo sapiens	64-69
27707801-5	2016	Indeed, we found that yeast cells assimilating hydroxybenzoates increase the expression of genes SFC1, LEU5, YHM2, and MPC1 coding for succinate/fumarate carrier, coenzyme A carrier, oxoglutarate/citrate carrier, and the subunit of pyruvate carrier, respectively.	Citric Acid	196-203	coenzyme A transporter	Saccharomyces cerevisiae S288C	103-107
27707801-5	2016	Indeed, we found that yeast cells assimilating hydroxybenzoates increase the expression of genes SFC1, LEU5, YHM2, and MPC1 coding for succinate/fumarate carrier, coenzyme A carrier, oxoglutarate/citrate carrier, and the subunit of pyruvate carrier, respectively.	Citric Acid	196-203	Yhm2p	Saccharomyces cerevisiae S288C	109-113
27707801-5	2016	Indeed, we found that yeast cells assimilating hydroxybenzoates increase the expression of genes SFC1, LEU5, YHM2, and MPC1 coding for succinate/fumarate carrier, coenzyme A carrier, oxoglutarate/citrate carrier, and the subunit of pyruvate carrier, respectively.	Citric Acid	196-203	pyruvate transporter MPC1	Saccharomyces cerevisiae S288C	119-123
27955746-12	2016	Brain AChE increased but PON1 and butyrylcholinesterase activities decreased by citric acid.	Citric Acid	80-91	paraoxonase 1	Rattus norvegicus	25-29
27955746-13	2016	Liver enzymes, the percentage of damaged blood lymphocytes, histopathological alterations and iNOS expression in brain and liver was decreased by citric acid.	Citric Acid	146-157	nitric oxide synthase 2	Rattus norvegicus	94-98
27227708-7	2016	RESULTS: The median percentage of platelets expressing P-selectin in citrate- and EDTA-plasma centrifuged at 2000 g for 10 min were 43% [interquartile range (IQR), 38%-53%] and 56% (IQR, 31%-78%), respectively (p=0.82).	Citric Acid	69-76	selectin P	Homo sapiens	55-65
27754898-1	2016	In the liver, citrate is a key metabolic intermediate involved in the regulation of glycolysis and lipid synthesis and reduced expression of the hepatic citrate SLC13A5 transporter has been shown to improve metabolic outcomes in various animal models.	Citric Acid	14-21	solute carrier family 13 member 5	Homo sapiens	161-168
27683012-6	2016	Furthermore, residues located outside of the putative citrate binding site, Q77 and T86, may also play a role in NaCT inhibition by compounds 2: and 4: Our results provide new insight into the mechanism of transport and inhibition in NaCT and the SLC13 family.	Citric Acid	54-61	solute carrier family 13 member 5	Homo sapiens	113-117
27683012-6	2016	Furthermore, residues located outside of the putative citrate binding site, Q77 and T86, may also play a role in NaCT inhibition by compounds 2: and 4: Our results provide new insight into the mechanism of transport and inhibition in NaCT and the SLC13 family.	Citric Acid	54-61	solute carrier family 13 member 5	Homo sapiens	234-238
27754898-2	2016	Although inhibition of hepatic extracellular citrate uptake through SLC13A5 has been suggested as a potential therapeutic approach for Type-2 diabetes and/or fatty liver disease, so far, only a few SLC13A5 inhibitors have been identified.	Citric Acid	45-52	solute carrier family 13 member 5	Homo sapiens	68-75
27809681-2	2016	MATERIALS &amp; METHODS: Effects of citrate-stabilized CaF2 and SrF2: Yb, Er NPs (13-15 nm) on human dendritic cells and neurons were assessed in vitro.	Citric Acid	36-43	CCR4-NOT transcription complex subunit 8	Homo sapiens	55-59
28331816-10	2017	Furthermore, we were able to show that microRNA 27a and/or microRNA 96 are important regulators of gap junction signalling, the rearrangement of the actin cytoskeleton as well as the citric acid cycle, which represent the most affected pathways with regard to inhibitory effects of ATRA in 3T3-L1 preadipocytes.	Citric Acid	183-194	microRNA 96	Mus musculus	59-70
27995584-1	2016	In present work, the effect of citric acid (CA) addition in different amounts (0, 1, 5 and 10 ml) on the structure of hydroxyapatite (HAp) was investigated using X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM) and energy dispersive X-ray (EDX) spectroscopy techniques.	Citric Acid	31-42	reticulon 3	Homo sapiens	134-137
27769451-2	2016	Our biosensing approach provides an especial and significant detection mechanism: CS can catalyze the essential condensation reaction between acetyl-coenzyme A (Ac-CoA) and oxaloacetate (OAA) to form citrate and CoA; then, in the presence of Ag(I), CoA-Ag(I) CP can be in situ formed because of the strong complexation ability of thiol groups of CoA toward Ag(I).	Citric Acid	200-207	citrate synthase	Homo sapiens	82-84
27775118-1	2016	We performed comprehensive studies on the photoluminescence properties of the carbon dots prepared from citric acid (C-dotsCA) and citric acid + ethylenediamine (C-dotsCA+EDA).	Citric Acid	131-142	ectodysplasin A	Homo sapiens	171-174
27912843-5	2016	Strategies aiming to increase cytosolic citrate should be developed and tested in humans, knowing that experimental studies have shown that administration of citrate and/or inhibition of ACLY arrest tumor growth, inhibit the expression of the key anti-apoptotic factor Mcl-1, reverse cell dedifferentiation and increase sensibility to cisplatin.	Citric Acid	40-47	ATP citrate lyase	Homo sapiens	187-191
27845736-2	2016	The objective of this study is to optimize polyethylene glycol (PEG)/citrate based on an aqueous two-phase system (ATPS) and Response Surface Methodology (RSM) to purify protease from Penicillium candidum (PCA 1/TT031).	Citric Acid	69-76	prostate cancer associated transcript 1	Homo sapiens	206-211
27912843-5	2016	Strategies aiming to increase cytosolic citrate should be developed and tested in humans, knowing that experimental studies have shown that administration of citrate and/or inhibition of ACLY arrest tumor growth, inhibit the expression of the key anti-apoptotic factor Mcl-1, reverse cell dedifferentiation and increase sensibility to cisplatin.	Citric Acid	158-165	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	269-274
27366965-5	2016	This citrate-modified NaYbF4:Tm@CaF2@NaDyF4 nanocomposite was used as a multifunctional contrast agent for trimodal lymphatic bioimaging with T2-weighted magnetic resonance imaging (MRI), CT, and UCL imaging.	Citric Acid	5-12	CCR4-NOT transcription complex subunit 8	Homo sapiens	32-36
27796299-5	2016	Mutant LCN2 strips iron from transferrin and citrate, and delivers it into the urine.	Citric Acid	45-52	lipocalin 2	Mus musculus	7-11
27063365-1	2016	BACKGROUND AND AIMS: Phosphoenolpyruvate carboxylase (PEPC) is a tightly regulated enzyme that controls carbohydrate partitioning to organic acid anions (malate, citrate) excreted in copious amounts by cluster roots of inorganic phosphate (Pi)-deprived white lupin plants.	Citric Acid	162-169	phosphoenolpyruvate carboxykinase 1	Homo sapiens	21-52
27063365-1	2016	BACKGROUND AND AIMS: Phosphoenolpyruvate carboxylase (PEPC) is a tightly regulated enzyme that controls carbohydrate partitioning to organic acid anions (malate, citrate) excreted in copious amounts by cluster roots of inorganic phosphate (Pi)-deprived white lupin plants.	Citric Acid	162-169	phosphoenolpyruvate carboxykinase 1	Homo sapiens	54-58
27063365-1	2016	BACKGROUND AND AIMS: Phosphoenolpyruvate carboxylase (PEPC) is a tightly regulated enzyme that controls carbohydrate partitioning to organic acid anions (malate, citrate) excreted in copious amounts by cluster roots of inorganic phosphate (Pi)-deprived white lupin plants.	Citric Acid	162-169	5'-nucleotidase, cytosolic IIIA	Homo sapiens	259-264
27725912-1	2016	Pyruvate dehydrogenase A1 (PDHA1) serves as a gate-keeper enzyme link between glycolysis and the mitochondrial citric acid cycle.	Citric Acid	111-122	pyruvate dehydrogenase E1 subunit alpha 1	Homo sapiens	0-25
27725912-1	2016	Pyruvate dehydrogenase A1 (PDHA1) serves as a gate-keeper enzyme link between glycolysis and the mitochondrial citric acid cycle.	Citric Acid	111-122	pyruvate dehydrogenase E1 subunit alpha 1	Homo sapiens	27-32
27560955-0	2016	Letter to the Editor: Re: Decontamination of Anodized Implant Surface With Different Modalities for Peri-Implantitis Treatment: Lasers and Mechanical Debridement With Citric Acid.	Citric Acid	167-178	perilipin 1	Homo sapiens	100-104
27481896-8	2016	A lower citrate concentration was observed in nitrate-grown cucumbers, which was associated with lower MATE (multidrug and toxin compound extrusion) family gene and citrate synthase (CS) gene expression, as well as lower CS activity.	Citric Acid	8-15	cysteine synthase	Cucumis sativus	165-181
27481896-8	2016	A lower citrate concentration was observed in nitrate-grown cucumbers, which was associated with lower MATE (multidrug and toxin compound extrusion) family gene and citrate synthase (CS) gene expression, as well as lower CS activity.	Citric Acid	8-15	cysteine synthase	Cucumis sativus	183-185
27481896-8	2016	A lower citrate concentration was observed in nitrate-grown cucumbers, which was associated with lower MATE (multidrug and toxin compound extrusion) family gene and citrate synthase (CS) gene expression, as well as lower CS activity.	Citric Acid	8-15	cysteine synthase	Cucumis sativus	221-223
27656674-9	2016	Succinate acts as a signaling molecule by binding to a G-protein-coupled receptor termed GPR91, "Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors" (W. He, F.J. Miao, D.C. Lin, R.T. Schwandner, Z. Wang, J. Gao, J.L.	Citric Acid	97-108	succinate receptor 1	Rattus norvegicus	89-94
27818933-2	2016	Citrate uptake modifies intracellular hepatic energy metabolism and is controlled by the conserved sodium-dicarboxylate cotransporter solute carrier family 13 member 5 (SLC13A5, mammalian homolog of INDY: mINDY).	Citric Acid	0-7	solute carrier family 13 member 5	Homo sapiens	169-176
27818933-2	2016	Citrate uptake modifies intracellular hepatic energy metabolism and is controlled by the conserved sodium-dicarboxylate cotransporter solute carrier family 13 member 5 (SLC13A5, mammalian homolog of INDY: mINDY).	Citric Acid	0-7	solute carrier family 13 (sodium-dependent citrate transporter), member 5	Mus musculus	199-203
27818933-2	2016	Citrate uptake modifies intracellular hepatic energy metabolism and is controlled by the conserved sodium-dicarboxylate cotransporter solute carrier family 13 member 5 (SLC13A5, mammalian homolog of INDY: mINDY).	Citric Acid	0-7	solute carrier family 13 (sodium-dependent citrate transporter), member 5	Mus musculus	205-210
27389143-5	2016	Since these citrate-EDTA stabilized CeNPs exhibited catalase and oxidase activity in cell-free systems and in in vitro models of ischemic oxidative stress, we hypothesize that antioxidant activity is the protective mechanism prolonging survival in the SOD1G93A mice.	Citric Acid	12-19	superoxide dismutase 1, soluble	Mus musculus	252-256
27813585-12	2016	Infarction area and caspase-3 and CAM levels were significantly lower in the citrate groups compared with the model group (P &lt; 0.05).	Citric Acid	77-84	caspase 3	Rattus norvegicus	20-29
27813585-12	2016	Infarction area and caspase-3 and CAM levels were significantly lower in the citrate groups compared with the model group (P &lt; 0.05).	Citric Acid	77-84	calmodulin 1	Rattus norvegicus	34-37
27813585-13	2016	Citrate can reduce myocardial cell apoptosis, alleviating ventricular arrhythmia and protecting the myocardium by reducing serum calcium ion concentration and downregulating caspase-3 and CAM expression.	Citric Acid	0-7	caspase 3	Rattus norvegicus	174-183
27813585-13	2016	Citrate can reduce myocardial cell apoptosis, alleviating ventricular arrhythmia and protecting the myocardium by reducing serum calcium ion concentration and downregulating caspase-3 and CAM expression.	Citric Acid	0-7	calmodulin 1	Rattus norvegicus	188-191
27302170-8	2016	The TCA intermediates alpha-KG and citrate potentiated the malignant character of NPC cells, in part by altering IKKalpha-dependent EMT gene expression.	Citric Acid	35-42	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	113-121
28002912-6	2016	N-terminal propeptide of type I procollagen (PINP) correlated with 24-h excretion of potassium, calcium and citrate.	Citric Acid	108-115	collagen type I alpha 2 chain	Homo sapiens	25-43
27307049-9	2016	Conditioning by EDTA, phosphoric acid, and citric acid exposed growth factors on dentine and triggered an upregulation in genes associated with mineralized differentiation, osteopontin, and alkaline phosphatase in DPSCs cultured on dentine.	Citric Acid	43-54	secreted phosphoprotein 1	Homo sapiens	173-184
27474283-2	2016	The proposed method can be easily performed by introducing the premixing of NAC and Hg(2+) into as-prepared citrate-capped AuNPs solution.	Citric Acid	108-115	synuclein alpha	Homo sapiens	76-79
27473766-3	2016	The goal of this research was to assess whether sustained release of SDF-1, a chemokine that promotes endothelial progenitor cell homing and angiogenesis, from a citrate-based antioxidant thermoresponsive polymer would significantly improve impaired dermal wound healing in diabetes.	Citric Acid	162-169	chemokine (C-X-C motif) ligand 12	Mus musculus	69-74
27187685-4	2016	Samples were analysed for levels of MMPs in corresponding citrate plasma and serum.	Citric Acid	58-65	matrix metallopeptidase 1	Homo sapiens	36-40
27187685-8	2016	We conclude that future studies regarding MMPs as biological markers in cancer should consider the use of citrate plasma instead of serum.	Citric Acid	106-113	matrix metallopeptidase 1	Homo sapiens	42-46
27179853-10	2016	Additionally, there were 2 differentially expressed genes coding for an intracellular fatty acid transporter (FABP4), an intermediate molecule of the citric acid cycle (SUCNR1), and 2 heat shock proteins (HSP70, HSPB8) that could be related to high protein production.	Citric Acid	150-161	fatty acid-binding protein, adipocyte	Ovis aries	110-115
27179853-10	2016	Additionally, there were 2 differentially expressed genes coding for an intracellular fatty acid transporter (FABP4), an intermediate molecule of the citric acid cycle (SUCNR1), and 2 heat shock proteins (HSP70, HSPB8) that could be related to high protein production.	Citric Acid	150-161	succinate receptor 1	Ovis aries	169-175
27260862-7	2016	The insulin-sensitizing and hypotensive effect, however, depend on citrate as the accompanying anion.	Citric Acid	67-74	insulin	Homo sapiens	4-11
27380437-3	2016	Histidine and citrate buffers with/without sodium chloride were employed to modulate the mAb"s conformational stability, solubility (in the presence of polyethylene glycol, PEG), and protein-protein interactions as measured by differential scanning calorimetry, PEG precipitation, and static light scattering, respectively.	Citric Acid	14-21	progestagen associated endometrial protein	Homo sapiens	262-265
27099338-5	2016	This acetylation was blocked by pharmacological inhibition of mitochondrial citrate export (a source for mitochondria-derived acetyl-CoA in the cytosol), was dependent on the alpha-tubulin acetyltransferase (alphaTAT) and was coupled to a loss in function of the cytosolic histone deacetylase, HDAC6.	Citric Acid	76-83	alpha tubulin acetyltransferase 1	Homo sapiens	175-217
27146323-1	2016	In this report, we have studied the recognition of citrate anions adsorbed on the surface of silver nanoparticles (cit-Ag-NPs), by macrocyclic polyammonium cations (MCPACs): Me6 [14]ane-N4 H8 (4+) (Tet-A/Tet-B cations) and [32]ane-N8 H16 (8+) , which are well reputed anion recognizers and are treated as to mimic of biological polyamines.	Citric Acid	51-58	protocadherin gamma subfamily B, 7	Homo sapiens	174-177
27101767-10	2016	After citric acid attack, nHAp@MSN exhibited the highest acid-resistant stability among the four groups.	Citric Acid	6-17	moesin	Homo sapiens	31-34
27099338-5	2016	This acetylation was blocked by pharmacological inhibition of mitochondrial citrate export (a source for mitochondria-derived acetyl-CoA in the cytosol), was dependent on the alpha-tubulin acetyltransferase (alphaTAT) and was coupled to a loss in function of the cytosolic histone deacetylase, HDAC6.	Citric Acid	76-83	histone deacetylase 6	Homo sapiens	294-299
27119351-9	2016	MIR126 also reduced pyruvate dehydrogenase kinase (PDK) and acetyl-CoA-citrate lyase (ACL) expression, leading to the accumulation of cytosolic citrate and paradoxical inhibition of pyruvate dehydrogenase (PDH) activity.	Citric Acid	71-78	microRNA 126a	Mus musculus	0-6
27125548-1	2016	Adaptation to anchorage-independent growth requires IDH1-mediated changes in citrate metabolism.	Citric Acid	77-84	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	52-56
27672436-6	2016	We illustrate the utility of these methods by presenting case studies in which rational integration of computation and experiment was used to characterize SLC members that transport key nutrients and metabolites, including the amino acid transporters LAT-1 and ASCT2, the SLC13 family of citric acid cycle intermediate transporters, and the glucose transporter GLUT1.	Citric Acid	288-299	solute carrier family 7 member 5	Homo sapiens	251-256
27125629-9	2016	Among patients with calculated insulin resistance, stone burden was greater (17.6 mm vs. 6.3 mm, p = 0.002) and 24-hour urine samples revealed higher urine calcium (293 mg/d vs. 159 mg/d, p = 0.02) and lower urine pH and citrate (454 mg/d vs. 639 mg/d, p = 0.04 and 5.83 vs. 6.33, p = 0.04, respectively).	Citric Acid	221-228	insulin	Homo sapiens	31-38
27021274-7	2016	Concerning the impact on cell cycle dynamics, both Cit30 and PEG30 AgNPs affected cell cycle regulation of HaCaT cells, but, again, citrate-coating induced more drastic effects, showing earlier downregulation of cyclin B1 gene and cellular arrest at the G2 phase.	Citric Acid	132-139	cyclin B1	Homo sapiens	212-221
27102694-9	2016	In the branch of regional citrate anticoagulation a higher value of functional fibrinogen is apparent.	Citric Acid	26-33	fibrinogen beta chain	Homo sapiens	79-89
27213574-4	2016	Since capsaicin, citric acid, and bradykinin evoked coughing in guinea pigs can be inhibited by drugs that antagonize the transient receptor potential cation channel, subfamily V, member 1 (TRPV1), it was reasoned that the virally-induced hypertussive state may involve alterations in TPRV1 activity.	Citric Acid	17-28	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	190-195
27091002-7	2016	The BDBA-induced aggregation of citrate-capped AuNPs can be paired with the glucose oxidase (GOx)-glucose system to design a colorimetric probe for glucose.	Citric Acid	32-39	hydroxyacid oxidase 1	Homo sapiens	76-91
27091002-7	2016	The BDBA-induced aggregation of citrate-capped AuNPs can be paired with the glucose oxidase (GOx)-glucose system to design a colorimetric probe for glucose.	Citric Acid	32-39	hydroxyacid oxidase 1	Homo sapiens	93-96
26547618-4	2016	In the presence of acetylcholinesterase (AChE) and acetylthiocholine (ATCl), the AChE catalyzes the hydrolysis of ATCl into positively charged thiocholine which would replace the citrate on AuNPs through the strong AuS bond and convert the negative charged surface to be positively charged.	Citric Acid	179-186	acetylcholinesterase (Cartwright blood group)	Homo sapiens	19-39
26857608-2	2016	RESULTS: After optimizing the fusion orientation in shake-flask culture, HSA-TMP-TMP was expressed at 0.4 g/l in Pichia pastoris grown in a 20 l bioreactor, during which pH was controlled at 5 by addition of NH4OH and citric acid.	Citric Acid	218-229	CD24a antigen	Mus musculus	73-84
26590824-2	2016	In 2004, GPR91 and GPR99 were identified as receptors for the citric acid cycle intermediates, succinate and alpha-ketoglutarate, respectively.	Citric Acid	62-73	succinate receptor 1	Mus musculus	9-14
26590824-2	2016	In 2004, GPR91 and GPR99 were identified as receptors for the citric acid cycle intermediates, succinate and alpha-ketoglutarate, respectively.	Citric Acid	62-73	oxoglutarate (alpha-ketoglutarate) receptor 1	Mus musculus	19-24
26718472-7	2016	When the supplementation of citric acid in the fermentation medium was controlled at 0.3% (w/v), the concentration of erythritol produced from the wild-type and To-HOG1 knockout mutant strains improved by 18.21% and 21.65%, respectively.	Citric Acid	28-39	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	164-168
27120592-8	2016	By comparing the contents of these compounds with gene expression and enzymatic activity levels, we determined that cytoplasmic NAD-dependent malate dehydrogenase (cyNAD-MDH) and mitochondrial citrate synthase (mCS) play important regulatory roles in the malic and citric acid biosynthetic pathways.	Citric Acid	265-276	sperm mitochondria-associated cysteine-rich protein	Mus musculus	211-214
27097687-3	2016	Here, we investigated the potential use of a biodegradable citrate-based thermosensitive macromolecule, poly(polyethyleneglycol citrate-co-N-isopropylacrylamide) (PPCN) mixed with gelatin (PPCNG) as a scaffold for the delivery of BMP9-stimulated MSCs to promote localized bone formation.	Citric Acid	59-66	growth differentiation factor 2	Mus musculus	230-234
26655179-7	2016	The three strategies involved immobilization of Anti-CA125 antibody - (1) after EDC-NHS activation of citrate stabilized gold nanoparticles, (2) directly onto citrate stabilized gold nanoparticles and (3) directly onto L-Asparagine stabilized gold nanoparticles modified electrode surfaces.	Citric Acid	102-109	mucin 16, cell surface associated	Homo sapiens	53-58
27049945-10	2016	Isotope tracing revealed that in spheroids, isocitrate/citrate produced reductively in the cytosol could enter the mitochondria and participate in oxidative metabolism, including oxidation by IDH2.	Citric Acid	47-54	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	192-196
27049945-13	2016	Together, the data indicate that adaptation to anchorage independence requires a fundamental change in citrate metabolism, initiated by IDH1-dependent reductive carboxylation and culminating in suppression of mitochondrial ROS.	Citric Acid	103-110	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	136-140
26936970-1	2016	The 2-oxoglutarate dehydrogenase (OGDH) complex is an important control point in vertebrate mitochondrial oxidative metabolism, including in the citrate cycle and catabolism of alternative fuels including glutamine.	Citric Acid	145-152	oxoglutarate dehydrogenase	Homo sapiens	4-32
26936970-1	2016	The 2-oxoglutarate dehydrogenase (OGDH) complex is an important control point in vertebrate mitochondrial oxidative metabolism, including in the citrate cycle and catabolism of alternative fuels including glutamine.	Citric Acid	145-152	oxoglutarate dehydrogenase	Homo sapiens	34-38
26930370-9	2016	Citrate level was reduced in serum of FSHD patients, but elevated in LGMD-2B patients.	Citric Acid	0-7	FSHMD1A	Homo sapiens	38-42
26930370-9	2016	Citrate level was reduced in serum of FSHD patients, but elevated in LGMD-2B patients.	Citric Acid	0-7	dysferlin	Homo sapiens	69-76
26978279-5	2016	Citric acid, a fumarase inhibitor, prevented the conversion of added fumaric acid in rat plasma.	Citric Acid	0-11	fumarate hydratase	Rattus norvegicus	15-23
27182133-6	2016	Significantly better FCR was observed in groups supplemented with 1% citric acid and 1% citric acid along with antibiotic followed by antibiotic along with organic acids supplemented group.	Citric Acid	69-80	FCR	Gallus gallus	21-24
27182133-6	2016	Significantly better FCR was observed in groups supplemented with 1% citric acid and 1% citric acid along with antibiotic followed by antibiotic along with organic acids supplemented group.	Citric Acid	88-99	FCR	Gallus gallus	21-24
27182133-7	2016	CONCLUSION: Growth performance of birds in terms of body weight, body weight gain, and FCR improved significantly in 1% citric acid which was significantly higher than antibiotic supplemented group.	Citric Acid	120-131	FCR	Gallus gallus	87-90
26863933-5	2016	Within the cytosol, citrate is readily metabolised by ATP-citrate lyase into acetyl-CoA - the metabolic precursor of endogenously produced lipids and cholesterol.	Citric Acid	20-27	ATP citrate lyase	Mus musculus	54-71
26863933-10	2016	However, the group receiving citrate+sucrose showed augmented fasting glycaemia, glucose intolerance and the expression of pro-inflammatory cytokines (TNF-alpha, IL-1beta, IL-6 and IL-10) in their AT.	Citric Acid	29-36	tumor necrosis factor	Mus musculus	151-160
26863933-10	2016	However, the group receiving citrate+sucrose showed augmented fasting glycaemia, glucose intolerance and the expression of pro-inflammatory cytokines (TNF-alpha, IL-1beta, IL-6 and IL-10) in their AT.	Citric Acid	29-36	interleukin 1 beta	Mus musculus	162-170
26863933-10	2016	However, the group receiving citrate+sucrose showed augmented fasting glycaemia, glucose intolerance and the expression of pro-inflammatory cytokines (TNF-alpha, IL-1beta, IL-6 and IL-10) in their AT.	Citric Acid	29-36	interleukin 6	Mus musculus	172-176
26863933-10	2016	However, the group receiving citrate+sucrose showed augmented fasting glycaemia, glucose intolerance and the expression of pro-inflammatory cytokines (TNF-alpha, IL-1beta, IL-6 and IL-10) in their AT.	Citric Acid	29-36	interleukin 10	Mus musculus	181-186
27337897-5	2016	Moreover, the inhibitory ability displayed a decreasing order of citric acid, oxalic acid, and malic acid when their concentrations were 20 mmol   L-1, which is related to the molecular structure and acidity of the three LMWOAs.	Citric Acid	65-76	immunoglobulin kappa variable 1-16	Homo sapiens	147-150
26547618-4	2016	In the presence of acetylcholinesterase (AChE) and acetylthiocholine (ATCl), the AChE catalyzes the hydrolysis of ATCl into positively charged thiocholine which would replace the citrate on AuNPs through the strong AuS bond and convert the negative charged surface to be positively charged.	Citric Acid	179-186	acetylcholinesterase (Cartwright blood group)	Homo sapiens	41-45
26547618-4	2016	In the presence of acetylcholinesterase (AChE) and acetylthiocholine (ATCl), the AChE catalyzes the hydrolysis of ATCl into positively charged thiocholine which would replace the citrate on AuNPs through the strong AuS bond and convert the negative charged surface to be positively charged.	Citric Acid	179-186	acetylcholinesterase (Cartwright blood group)	Homo sapiens	81-85
27069776-8	2016	This suggests that NaCT inhibition will have a limited impact on hepatic citrate concentrations across species.	Citric Acid	73-80	solute carrier family 13 member 5	Homo sapiens	19-23
26811873-3	2016	Fifty-four compounds were detected, and the contents of metabolites from the citric acid cycle increased in response to the insulin treatment for 4 h, which was sensitive to U0126 and LY294002, inhibitors for mitogen-activated protein kinase kinase-1 and phosphoinositide 3-kinase, respectively.	Citric Acid	77-88	insulin	Homo sapiens	124-131
26811873-8	2016	The present study revealed the unexpected accumulation of citric acid cycle metabolites in adipocytes by insulin.	Citric Acid	58-69	insulin	Homo sapiens	105-112
26939608-7	2016	We employed a push/pull strategy to shunt citrate towards ACL by deletion of the mitochondrial NAD(+)-dependent isocitrate dehydrogenase (IDH1) and engineering higher flux through the upper mevalonate pathway.	Citric Acid	42-49	isocitrate dehydrogenase (NAD(+)) IDH1	Saccharomyces cerevisiae S288C	138-142
26808164-3	2016	SUCNR1 has been classified as an orphan receptor until a landmark study paired it with succinate, a citric acid cycle intermediate.	Citric Acid	100-111	succinate receptor 1	Homo sapiens	0-6
26916297-9	2016	H3Cit correlated positively with thrombin-antithrombin complex (p=0.004) and soluble P-selectin (p&lt;0.001), further linking NETosis to the pro-thrombotic state.	Citric Acid	0-5	selectin P	Homo sapiens	85-95
27069776-0	2016	Model-Based Assessment of Plasma Citrate Flux Into the Liver: Implications for NaCT as a Therapeutic Target.	Citric Acid	33-40	solute carrier family 13 member 5	Homo sapiens	79-83
27069776-2	2016	For this reason, the sodium-coupled citrate transporter (NaCT), a plasma membrane transporter that governs hepatic influx of plasma citrate in human, is being explored as a potential therapeutic target for metabolic disorders.	Citric Acid	36-43	solute carrier family 13 member 5	Homo sapiens	57-61
26911930-5	2016	METHODS: Phosphofructokinase (PFK) activity was measured in the presence of both of its substrates, fructose-6-phosphate (F6P) and ATP, as well as some allosteric effectors: Fructose- 2,6 - bisphosphate (F2, 6BP), citrate and AMP.	Citric Acid	214-221	Phosphofructokinase	Drosophila melanogaster	9-28
26911930-5	2016	METHODS: Phosphofructokinase (PFK) activity was measured in the presence of both of its substrates, fructose-6-phosphate (F6P) and ATP, as well as some allosteric effectors: Fructose- 2,6 - bisphosphate (F2, 6BP), citrate and AMP.	Citric Acid	214-221	Phosphofructokinase	Drosophila melanogaster	30-33
26679997-8	2016	Glucose-derived pyruvate is oxidized via PDH to generate citrate in the mitochondria.	Citric Acid	57-64	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	41-44
26734723-2	2016	In a previous report, we discovered dicarboxylate 1a (PF-06649298) which inhibits the transport of citrate in in vitro and in vivo settings via a specific interaction with NaCT.	Citric Acid	99-106	solute carrier family 13 member 5	Homo sapiens	172-176
26176209-5	2015	A polyclonal anti-human EGFR Ab was conjugated to citrate-coated gold nanoparticles (AuNPs) and used as a signaling probe.	Citric Acid	50-57	epidermal growth factor receptor	Homo sapiens	24-28
26801765-5	2016	RESULTS: Citrate-coated Ag ENMs of various sizes (10-40 nm) reacted with Cu(II) azurin resulted in an order of magnitude more dissolved ionic silver (Ag(I)(aq)) than samples of Ag ENMs only, ENMs mixed Cu(II) ions, or control proteins such as cytochrome c and horse radish peroxidase.	Citric Acid	9-16	cytochrome c, somatic	Equus caballus	243-255
26695452-2	2016	Concentrations of 5-10 mol % of each of Fe and Co have been doped for the B-site of BCS by citric acid autocombustion method.	Citric Acid	91-102	BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone	Homo sapiens	84-87
26755275-9	2016	Isocitrate is interconverted with citrate via the intermediate aconitate in a reaction catalyzed by the enzyme aconitase 1 (ACO1).	Citric Acid	3-10	aconitase 1	Homo sapiens	111-122
26755275-9	2016	Isocitrate is interconverted with citrate via the intermediate aconitate in a reaction catalyzed by the enzyme aconitase 1 (ACO1).	Citric Acid	3-10	aconitase 1	Homo sapiens	124-128
27156328-13	2016	CONCLUSIONS: Compared to the serum tube, NaF/citrate plasma tube is suitable for shipping venous whole blood samples within 10 hours at room temperature without undergoing significant glycolysis.	Citric Acid	45-52	C-X-C motif chemokine ligand 8	Homo sapiens	41-44
26643360-5	2016	In LPS and IFN-gamma-activated macrophages (M1 macrophages), there is decreased respiration and a broken Krebs cycle, leading to accumulation of succinate and citrate, which act as signals to alter immune function.	Citric Acid	159-166	interferon gamma	Mus musculus	11-20
26358042-2	2016	It has been recently identified in cells of macrophage lineage as a product of an enzyme encoded by immunoresponsive gene 1 (Irg1), acting on the citric acid cycle intermediate cis-aconitate.	Citric Acid	146-157	aconitate decarboxylase 1	Mus musculus	100-123
26358042-2	2016	It has been recently identified in cells of macrophage lineage as a product of an enzyme encoded by immunoresponsive gene 1 (Irg1), acting on the citric acid cycle intermediate cis-aconitate.	Citric Acid	146-157	aconitate decarboxylase 1	Mus musculus	125-129
27096063-8	2016	RESULTS: Intraperitoneal injection of citrate significantly reduced caspase-3 and PAI-1 protein levels and increased p-AKT level on the 5(th) week; EC in the heart was found to be increased as well.	Citric Acid	38-45	caspase 3	Mus musculus	68-77
27096063-8	2016	RESULTS: Intraperitoneal injection of citrate significantly reduced caspase-3 and PAI-1 protein levels and increased p-AKT level on the 5(th) week; EC in the heart was found to be increased as well.	Citric Acid	38-45	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	82-87
27096063-8	2016	RESULTS: Intraperitoneal injection of citrate significantly reduced caspase-3 and PAI-1 protein levels and increased p-AKT level on the 5(th) week; EC in the heart was found to be increased as well.	Citric Acid	38-45	thymoma viral proto-oncogene 1	Mus musculus	119-122
27306203-1	2016	Mutations of the mitochondrial citrate carrier (CIC) SLC25A1 cause combined D-2- and L-2-hydroxyglutaric aciduria (DL-2HGA; OMIM #615182), a neurometabolic disorder characterized by developmental delay, hypotonia, and seizures.	Citric Acid	31-38	solute carrier family 25 member 1	Homo sapiens	53-60
26753809-1	2016	Removal of Cr(VI) and citric acid (Cit) by heterogeneous photocatalytic Cr(VI) transformation under UV light over two commercial TiO2 samples (1 g L(-1)), Evonik P25 and Hombikat UV100, was studied at pH 2 and Cr(VI) concentrations between 0.2 and 3 mM, with a fixed [Cit]0/[Cr(VI)]0 molar ratio (MR) of 2.5.	Citric Acid	35-38	tubulin polymerization promoting protein	Homo sapiens	162-165
26753809-5	2016	Both kinetic experiments and TRMC measurements confirm that UV100 is not only more efficient than P25 for Cr(VI) and Cit removal, but it is also less influenced by the poisoning of the surface, consistent with its larger specific area.	Citric Acid	117-120	tubulin polymerization promoting protein	Homo sapiens	98-101
26734528-6	2015	Specific changes in the morphology of the surface layer were observed when mica was primed with a monolayer of small organic compounds (e.g., N-acetylcysteine, citric acid, thioglycolic or acid).	Citric Acid	160-171	MHC class I polypeptide-related sequence A	Homo sapiens	75-79
27408652-2	2015	HLRCC is an autosomal dominant condition caused by a mutation in the fumarate hydratase gene, which encodes for an enzyme in the citric acid cycle.	Citric Acid	129-140	fumarate hydratase	Homo sapiens	69-87
26595389-4	2015	The presence of citrate molecules on the crystal surface of the iron oxide was established by FTIR, TGA, DLS and zeta potential measurements.	Citric Acid	16-23	T-box transcription factor 1	Homo sapiens	100-103
25776985-7	2015	Analysis demonstrated that OT dry powders containing a mixture of citrate and zinc salts retained more than 90% of initial assay after 32 weeks storage and showed significant reduction in dimers and trisulfide formation (up to threefold reduction compared to control).	Citric Acid	66-73	oxytocin/neurophysin I prepropeptide	Homo sapiens	27-29
26454222-13	2015	CONCLUSION: SnF2 reduced step height formation overall when compared to NaF, but particularly when applied before citric acid immersion.	Citric Acid	114-125	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	12-16
26454222-14	2015	In contrast, NaF reduced step height when applied after citric acid immersion, but only in the presence of saliva.	Citric Acid	56-67	C-X-C motif chemokine ligand 8	Homo sapiens	13-16
26498726-11	2015	Among them, cystatin-B was increased 20- and 13-fold after exposure to citric and lactic acids, respectively.	Citric Acid	71-77	cystatin B	Homo sapiens	12-22
26620127-2	2015	Inhibition of hepatic extracellular citrate uptake, by blocking the sodium-coupled citrate transporter (NaCT or SLC13A5), has been suggested as a potential therapeutic approach to treat metabolic disorders.	Citric Acid	36-43	solute carrier family 13 member 5	Homo sapiens	104-108
26620127-2	2015	Inhibition of hepatic extracellular citrate uptake, by blocking the sodium-coupled citrate transporter (NaCT or SLC13A5), has been suggested as a potential therapeutic approach to treat metabolic disorders.	Citric Acid	36-43	solute carrier family 13 member 5	Homo sapiens	112-119
26620127-3	2015	NaCT transports citrate from the blood into the cell coupled to the transport of sodium ions.	Citric Acid	16-23	solute carrier family 13 member 5	Homo sapiens	0-4
26620127-4	2015	The studies herein report the identification and characterization of a novel small dicarboxylate molecule (compound 2) capable of selectively and potently inhibiting citrate transport through NaCT, both in vitro and in vivo.	Citric Acid	166-173	solute carrier family 13 member 5	Homo sapiens	192-196
26635626-0	2015	Age Differences of Salivary Alpha-Amylase Levels of Basal and Acute Responses to Citric Acid Stimulation Between Chinese Children and Adults.	Citric Acid	81-92	amylase alpha 1A	Homo sapiens	19-41
25977064-5	2015	Moreover, under high oxygen (75%) storage conditions, KCS combinations of glutamate, citrate and malate increased PFP (from 1.22 to 1.29 mmol peroxides/kg) and TBARS (from 0.37 to 0.40 mg MDA equivalents/kg mince).	Citric Acid	85-92	perforin 1	Homo sapiens	114-117
26459958-4	2015	Citrate-capped AuNPs (100 nm in diameter) functionalized with 0.01 orthopyridyl-disulfide-poly(ethylene glycol) (5 kDa)-N-hydroxysuccinimide (OPSS-PEG-NHS) conjugated to monoclonal antibodies per nm(2) and 5 muM HS-PEG (5 kDa) were colloidally stable in cell culture medium containing serum proteins.	Citric Acid	0-7	latexin	Homo sapiens	208-211
26266538-12	2015	In conclusion, Myc alters substrate preferences for the citric acid cycle during early pressure overload hypertrophy without negatively affecting cardiac function.	Citric Acid	56-67	myelocytomatosis oncogene	Mus musculus	15-18
26324167-2	2015	Citrate is imported from the circulation across the plasma membrane into liver cells mainly by the sodium-dependent citrate transporter (NaCT; SLC13A5).	Citric Acid	0-7	solute carrier family 13 member 5	Homo sapiens	137-141
26324167-2	2015	Citrate is imported from the circulation across the plasma membrane into liver cells mainly by the sodium-dependent citrate transporter (NaCT; SLC13A5).	Citric Acid	0-7	solute carrier family 13 member 5	Homo sapiens	143-150
26324167-5	2015	Interestingly, striking differences were found between mouse and human NaCT with respect to their sensitivities to citric acid cycle intermediates as substrates for these transporters.	Citric Acid	115-126	solute carrier family 13 member 5	Homo sapiens	71-75
26324167-7	2015	Mouse NaCT is fully active at physiologic plasma levels of citrate, but its human counterpart is not.	Citric Acid	59-66	solute carrier family 13 (sodium-dependent citrate transporter), member 5	Mus musculus	6-10
26324167-9	2015	The low sensitivity of human NaCT for citrate raises questions about the translatability of this target from the mouse to the human situation and raises doubts about the validity of this transporter as a therapeutic target for the treatment of metabolic diseases in humans.	Citric Acid	38-45	solute carrier family 13 member 5	Homo sapiens	29-33
26031345-1	2015	Apheresis donation using citrate causes acute decrease in serum calcium and increase in serum parathyroid hormone.	Citric Acid	25-32	parathyroid hormone	Homo sapiens	94-113
26254094-2	2015	Nrf1 specifically regulates pathways in lipid metabolism, amino acid metabolism, proteasomal degradation, the citric acid cycle, and the mitochondrial respiratory chain.	Citric Acid	110-121	nuclear respiratory factor 1	Homo sapiens	0-4
25828536-6	2015	Therefore, we developed a small scale procedure to isolate hBChE from citrate plasma.	Citric Acid	70-77	butyrylcholinesterase	Homo sapiens	59-64
26420908-5	2015	We found that alpha-ketoglutarate (alphaKG), the glutamine-derived metabolite that enters into the mitochondrial citric acid cycle, acted as a metabolic regulator of CD4(+) T cell differentiation.	Citric Acid	113-124	CD4 molecule	Homo sapiens	166-169
26043180-7	2015	Citrate, an ACAC activator, and CBM-301106, an inhibitor of malonyl CoA decarboxylase, which converts malonyl CoA to acetyl CoA, suppressed both meiotic induction and FAO induced by follicle-stimulating hormone, presumably by maintaining elevated malonyl CoA levels.	Citric Acid	0-7	acetyl-Coenzyme A carboxylase beta	Mus musculus	12-16
25036665-0	2015	Enhancement of mechanical properties, microstructure, and antimicrobial activities of zein films cross-linked using succinic anhydride, eugenol, and citric Acid.	Citric Acid	149-160	zein	Zea mays	86-90
25036665-3	2015	In this study, zein proteins were modified using citric acid, succinic anhydride, and eugenol as natural cross-linking agents in the wet state.	Citric Acid	49-60	zein	Zea mays	15-19
26303333-3	2015	A central regulator of hepatic lipid metabolism is cytosolic citrate that can either be derived from the mitochondrium or be taken up from the blood via the plasma membrane sodium citrate transporter NaCT, the product of the mammalian INDY gene (SLC13A5).	Citric Acid	61-68	solute carrier family 13 member 5	Homo sapiens	200-204
26303333-3	2015	A central regulator of hepatic lipid metabolism is cytosolic citrate that can either be derived from the mitochondrium or be taken up from the blood via the plasma membrane sodium citrate transporter NaCT, the product of the mammalian INDY gene (SLC13A5).	Citric Acid	61-68	solute carrier family 13 (sodium-dependent citrate transporter), member 5	Mus musculus	235-239
26303333-3	2015	A central regulator of hepatic lipid metabolism is cytosolic citrate that can either be derived from the mitochondrium or be taken up from the blood via the plasma membrane sodium citrate transporter NaCT, the product of the mammalian INDY gene (SLC13A5).	Citric Acid	61-68	solute carrier family 13 member 5	Homo sapiens	246-253
25348479-2	2015	The quality of spectral fitting of the (choline + creatine)/citrate ([Cho + Cr]/Cit) ratio at different field strengths and different coils is important for quantitative/semi-quantitative diagnosis of prostate cancer.	Citric Acid	60-67	citron rho-interacting serine/threonine kinase	Homo sapiens	80-83
26264645-2	2015	In the present study, elastin-like recombinamers hydrogels were produced by means of carbodiimide-catalyzed crosslinking with citric acid, a molecule suggested to be essential for bone nanostructure.	Citric Acid	126-137	elastin	Homo sapiens	22-29
26384929-0	2015	Recessive mutations in SLC13A5 result in a loss of citrate transport and cause neonatal epilepsy, developmental delay and teeth hypoplasia.	Citric Acid	51-58	solute carrier family 13 member 5	Homo sapiens	23-30
26529007-0	2015	Iron Absorption from Two Milk Formulas Fortified with Iron Sulfate Stabilized with Maltodextrin and Citric Acid.	Citric Acid	100-111	Weaning weight-maternal milk	Bos taurus	25-29
26378018-9	2015	Whereas AR increased citrate levels, AR-V7 reduced citrate mirroring metabolic shifts observed in CRPC patients.	Citric Acid	21-28	androgen receptor	Homo sapiens	8-10
26439475-14	2015	Overall, quality of the reporting of the included studies was considered moderate to poor, and there was a high risk of attrition bias in two studies.Compared with placebo or no intervention, citrate therapy significantly reduced the stone size (4 studies, 160 participants: RR 2.35, 95% CI 1.36 to 4.05).	Citric Acid	192-199	ribonucleotide reductase regulatory subunit M2	Homo sapiens	275-279
28626495-3	2015	In this study, the binding of the protein alpha-synuclein to citrate and (16-mercaptohexadecyl) trimethylammonium bromide (MTAB) coated 12 nm Au NPs is examined by heteronuclear single quantum coherence NMR spectroscopy to provide site-specific measurements of protein-nanoparticle binding.	Citric Acid	61-68	synuclein alpha	Homo sapiens	42-57
26269671-21	2015	CONCLUSION: Citrate excretion is decreased in BDL rats, at least in part, because of the higher NaDC1 expression.	Citric Acid	12-19	solute carrier family 13 member 2	Rattus norvegicus	96-101
26269671-22	2015	Using the outward gradient of citrate generated by NaDC1, Oat5 can reabsorb/eliminate different organic anions of pathophysiological importance.	Citric Acid	30-37	solute carrier family 13 member 2	Rattus norvegicus	51-56
26269671-22	2015	Using the outward gradient of citrate generated by NaDC1, Oat5 can reabsorb/eliminate different organic anions of pathophysiological importance.	Citric Acid	30-37	solute carrier family 22, member 24	Rattus norvegicus	58-62
26007236-7	2015	At hypoxia (5% O2), IDH2-related and unrelated (13)C-accumulation into citrate and malate increased 1.5-2.5-fold with unchanged IDH2 expression; whereas hypoxic 2HG formation did not.	Citric Acid	71-78	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	20-24
26002909-6	2015	Consistent with the function of FRD3 as a citrate efflux protein, the iron retention defect in gcn5 was rescued and fertility was partly restored by overexpressing FRD3.	Citric Acid	42-49	MATE efflux family protein	Arabidopsis thaliana	32-36
26002909-6	2015	Consistent with the function of FRD3 as a citrate efflux protein, the iron retention defect in gcn5 was rescued and fertility was partly restored by overexpressing FRD3.	Citric Acid	42-49	histone acetyltransferase of the GNAT family 1	Arabidopsis thaliana	95-99
26002909-6	2015	Consistent with the function of FRD3 as a citrate efflux protein, the iron retention defect in gcn5 was rescued and fertility was partly restored by overexpressing FRD3.	Citric Acid	42-49	MATE efflux family protein	Arabidopsis thaliana	164-168
26002909-7	2015	Moreover, iron retention in gcn5 roots was significantly reduced by the exogenous application of citrate.	Citric Acid	97-104	histone acetyltransferase of the GNAT family 1	Arabidopsis thaliana	28-32
26193703-6	2015	The Human FGF23 (C-Terminal) ELISA kit was used to measure FGF23 in citrate plasma.	Citric Acid	68-75	fibroblast growth factor 23	Homo sapiens	59-64
25753478-1	2015	Malic enzyme 1 (ME1) links the glycolytic and citric acid cycles and is important for NADPH production, glutamine metabolism, and lipogenesis.	Citric Acid	46-57	malic enzyme 1	Homo sapiens	0-14
25753478-1	2015	Malic enzyme 1 (ME1) links the glycolytic and citric acid cycles and is important for NADPH production, glutamine metabolism, and lipogenesis.	Citric Acid	46-57	malic enzyme 1	Homo sapiens	16-19
25874445-6	2015	RESULTS: Beta cells lacking LKB1 surprisingly display impaired mitochondrial metabolism and lower ATP levels following glucose stimulation, yet compensate for this by upregulating both uptake and synthesis of glutamine, leading to increased production of citrate.	Citric Acid	255-262	serine/threonine kinase 11	Mus musculus	28-32
26066995-4	2015	We investigated how citrate affects the function of a soluble CYP3A4 monooxygenase system consisting of equimolar amounts of CYP3A4 and cytochrome P450 reductase (CPR).	Citric Acid	20-27	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	62-68
26066995-6	2015	CYP3A4-substrate binding, reduction of CPR with NADPH, and interflavin and interprotein electron transfer were identified as citrate-sensitive steps.	Citric Acid	125-132	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-6
26066995-6	2015	CYP3A4-substrate binding, reduction of CPR with NADPH, and interflavin and interprotein electron transfer were identified as citrate-sensitive steps.	Citric Acid	125-132	cytochrome p450 oxidoreductase	Homo sapiens	39-42
25907923-6	2015	In addition the aqueous fraction of metabolites in BAT were profoundly affected by Arntl disruption, consistent with the dynamic role of this tissue in maintaining body temperature across the day-night cycle and an upregulation in fatty acid oxidation and citric acid cycle activity to generate heat during the day when rats are inactive (increases in 3-hydroxybutyrate and glutamate), and increased synthesis and storage of lipids during the night when rats feed more (increased concentrations of glycerol, choline and glycerophosphocholine).	Citric Acid	256-267	aryl hydrocarbon receptor nuclear translocator-like	Rattus norvegicus	83-88
26158292-5	2015	Here we show that p53 improved the ability of rapamycin to: 1) extend mouse life span, 2) suppress ionizing radiation (IR)-induced senescence-associated secretory phenotype (SASP) and 3) increase the levels of amino acids and citric acid in mouse embryonic stem (ES) cells.	Citric Acid	226-237	transformation related protein 53, pseudogene	Mus musculus	18-21
26114427-8	2015	Namely, metabolic products of the TCA cycle increased in PGC-1alpha-Tg mice, with increased levels of citrate (2.3-fold), succinate (2.2-fold), fumarate (2.8-fold), and malate (2.3-fold) observed.	Citric Acid	102-109	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	57-67
25702953-9	2015	The number of fragments per kilobase per million mapped reads of the mitochondrial aco2 gene was only 4.6, whereas that of the cytoplasmic aco1 was 41.5, indicating that the citrate comes from amino acids in the cytoplasm of parasitized cotton-melon aphids.	Citric Acid	174-181	1-aminocyclopropane-1-carboxylate oxidase 3-like	Gossypium hirsutum	139-143
26106407-2	2015	INDY is expressed in metabolically active tissues functioning as a transporter of Krebs cycle intermediates with the highest affinity for citrate.	Citric Acid	138-145	solute carrier family 13 (sodium-dependent citrate transporter), member 5	Mus musculus	0-4
26106407-6	2015	Citrate cleavage is a key event during lipid and glucose metabolism; thus, reduction of citrate due to Indy reduction alters these processes.	Citric Acid	0-7	solute carrier family 13 (sodium-dependent citrate transporter), member 5	Mus musculus	103-107
26106407-6	2015	Citrate cleavage is a key event during lipid and glucose metabolism; thus, reduction of citrate due to Indy reduction alters these processes.	Citric Acid	88-95	solute carrier family 13 (sodium-dependent citrate transporter), member 5	Mus musculus	103-107
26562994-7	2015	CONCLUSION: Among the representative strains of group I, II, III and IV, only the representative strain cp20 of group II has the ability of strong utilizing citrate obviously.	Citric Acid	157-164	lymphocyte cytosolic protein, molecular weight 20kD	Homo sapiens	104-108
26039450-2	2015	ATP citrate lyase (ACL) is a cytosolic enzyme that catalyzes mitochondria-derived citrate into oxaloacetate and acetyl-CoA.	Citric Acid	4-11	ATP citrate lyase	Homo sapiens	19-22
25619261-4	2015	In normal medium (0.4 mM calcium), citrate inhibited LPS-induced tumour necrosis factor (TNF)-alpha and interleukin (IL)-8 transcripts, whereas in medium supplemented with calcium (1.4 mM), TNF-alpha and IL-8 levels increased and appeared independent of calcium chelation.	Citric Acid	35-42	C-X-C motif chemokine ligand 8	Homo sapiens	104-122
25619261-4	2015	In normal medium (0.4 mM calcium), citrate inhibited LPS-induced tumour necrosis factor (TNF)-alpha and interleukin (IL)-8 transcripts, whereas in medium supplemented with calcium (1.4 mM), TNF-alpha and IL-8 levels increased and appeared independent of calcium chelation.	Citric Acid	35-42	tumor necrosis factor	Homo sapiens	190-199
25619261-4	2015	In normal medium (0.4 mM calcium), citrate inhibited LPS-induced tumour necrosis factor (TNF)-alpha and interleukin (IL)-8 transcripts, whereas in medium supplemented with calcium (1.4 mM), TNF-alpha and IL-8 levels increased and appeared independent of calcium chelation.	Citric Acid	35-42	C-X-C motif chemokine ligand 8	Homo sapiens	204-208
25619261-6	2015	Tricarballylic acid, an inhibitor of ATP-citrate lyase, blocked the ability of citrate to augment TNF-alpha, linking citrate"s augmentation effect with its metabolism by ATP-citrate lyase.	Citric Acid	41-48	tumor necrosis factor	Homo sapiens	98-107
25619261-6	2015	Tricarballylic acid, an inhibitor of ATP-citrate lyase, blocked the ability of citrate to augment TNF-alpha, linking citrate"s augmentation effect with its metabolism by ATP-citrate lyase.	Citric Acid	79-86	ATP citrate lyase	Homo sapiens	37-54
25619261-6	2015	Tricarballylic acid, an inhibitor of ATP-citrate lyase, blocked the ability of citrate to augment TNF-alpha, linking citrate"s augmentation effect with its metabolism by ATP-citrate lyase.	Citric Acid	79-86	tumor necrosis factor	Homo sapiens	98-107
25619261-6	2015	Tricarballylic acid, an inhibitor of ATP-citrate lyase, blocked the ability of citrate to augment TNF-alpha, linking citrate"s augmentation effect with its metabolism by ATP-citrate lyase.	Citric Acid	79-86	ATP citrate lyase	Homo sapiens	170-187
25619261-7	2015	In the presence of citrate, increased histone acetylation was observed in the TNF-alpha and IL-8 promoter regions of THP-1 cells.	Citric Acid	19-26	tumor necrosis factor	Homo sapiens	78-87
25619261-7	2015	In the presence of citrate, increased histone acetylation was observed in the TNF-alpha and IL-8 promoter regions of THP-1 cells.	Citric Acid	19-26	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
25771043-5	2015	The milk samples from cows with the DGAT1 KK genotype contained more stomatin, sphingomyelin, choline, and carnitine, and less citrate, creatine or phosphocreatine, glycerol-phosphocholine, mannose-like sugar, acetyl sugar phosphate, uridine diphosphate (UDP)-related sugar, and orotic acid compared with milk samples from cows with the DGAT1 AA genotype.	Citric Acid	127-134	diacylglycerol O-acyltransferase 1	Bos taurus	36-41
26028748-6	2015	Citric acid acted only as PPO non-competitive inhibitor with KI = 2.074 +- 0.363 mM.	Citric Acid	0-11	protoporphyrinogen oxidase	Homo sapiens	26-29
26237829-8	2015	However, the role played by glycosylated sAA content in sAA activity in healthy children increased after citric acid stimulation, while it decreased in splenic asthenia children.	Citric Acid	105-116	amylase alpha 1A	Homo sapiens	41-44
26237829-8	2015	However, the role played by glycosylated sAA content in sAA activity in healthy children increased after citric acid stimulation, while it decreased in splenic asthenia children.	Citric Acid	105-116	amylase alpha 1A	Homo sapiens	56-59
26237829-9	2015	CONCLUSION: Genetic factors like AMY1 copy number variations, and more importantly, sAA glycosylation abnormalities leading to attenuated sAA activity after citric acid stimulation, which were the main reasons of the attenuated sAA activity ratio in splenic asthenia children compared with healthy children.	Citric Acid	157-168	amylase alpha 1A	Homo sapiens	33-37
26237829-9	2015	CONCLUSION: Genetic factors like AMY1 copy number variations, and more importantly, sAA glycosylation abnormalities leading to attenuated sAA activity after citric acid stimulation, which were the main reasons of the attenuated sAA activity ratio in splenic asthenia children compared with healthy children.	Citric Acid	157-168	amylase alpha 1A	Homo sapiens	84-87
26237829-9	2015	CONCLUSION: Genetic factors like AMY1 copy number variations, and more importantly, sAA glycosylation abnormalities leading to attenuated sAA activity after citric acid stimulation, which were the main reasons of the attenuated sAA activity ratio in splenic asthenia children compared with healthy children.	Citric Acid	157-168	amylase alpha 1A	Homo sapiens	138-141
26237829-9	2015	CONCLUSION: Genetic factors like AMY1 copy number variations, and more importantly, sAA glycosylation abnormalities leading to attenuated sAA activity after citric acid stimulation, which were the main reasons of the attenuated sAA activity ratio in splenic asthenia children compared with healthy children.	Citric Acid	157-168	amylase alpha 1A	Homo sapiens	138-141
26010859-8	2015	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and citrate synthase (CS), which are involved in glycolysis and the citric acid cycle, respectively, were expressed at similar levels at 32 C and 37 C in pellet cultures, but the levels were significantly lower at 41 C. Expression of the chondrogenic markers, collagen type IIA1 (COL2A1) and aggrecan (ACAN), was higher at 37 C than at 32 C and 41 C in both culture systems.	Citric Acid	117-128	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	0-40
26010859-8	2015	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and citrate synthase (CS), which are involved in glycolysis and the citric acid cycle, respectively, were expressed at similar levels at 32 C and 37 C in pellet cultures, but the levels were significantly lower at 41 C. Expression of the chondrogenic markers, collagen type IIA1 (COL2A1) and aggrecan (ACAN), was higher at 37 C than at 32 C and 41 C in both culture systems.	Citric Acid	117-128	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	42-47
26010859-8	2015	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and citrate synthase (CS), which are involved in glycolysis and the citric acid cycle, respectively, were expressed at similar levels at 32 C and 37 C in pellet cultures, but the levels were significantly lower at 41 C. Expression of the chondrogenic markers, collagen type IIA1 (COL2A1) and aggrecan (ACAN), was higher at 37 C than at 32 C and 41 C in both culture systems.	Citric Acid	117-128	citrate synthase	Homo sapiens	53-69
26010859-8	2015	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and citrate synthase (CS), which are involved in glycolysis and the citric acid cycle, respectively, were expressed at similar levels at 32 C and 37 C in pellet cultures, but the levels were significantly lower at 41 C. Expression of the chondrogenic markers, collagen type IIA1 (COL2A1) and aggrecan (ACAN), was higher at 37 C than at 32 C and 41 C in both culture systems.	Citric Acid	117-128	citrate synthase	Homo sapiens	71-73
25577059-6	2015	Citric acid could be effective in inhibiting lysozyme from interacting with other proteins during PEF processing.	Citric Acid	0-11	lysozyme	Homo sapiens	45-53
25652229-15	2015	IRP-1 protein levels are not regulated by ROS, but IRP-1-dependent ferritin expression may decrease ROS and increase total glutathione levels, suggesting that ferritin levels are more important than citrate metabolism in protecting renal cells against iron.	Citric Acid	199-206	aconitase 1	Rattus norvegicus	51-56
25655949-10	2015	Only Delta(9)-tetrahydrocannabinol inhibited TNF-alpha-enhanced vagal-induced bronchoconstriction, neutrophil recruitment to the airways, and citric acid-induced cough responses.	Citric Acid	142-153	tumor necrosis factor	Cavia porcellus	45-54
25724137-5	2015	In the present study, a mesoporous metalosilicate, Neusilin( ) US2, was incorporated in SDs prepared by using malic, tartaric and citric acids.	Citric Acid	130-142	usherin	Homo sapiens	63-66
25880638-8	2015	Furthermore, the levels of lactate (inhibitor of hexokinase and phosphofructokinase-1) and citrate (inhibitor of phosphofructokinase-1 and pyruvate kinase) were increased in fed and fasted ShcKO versus WT mice.	Citric Acid	91-98	phosphofructokinase, liver, B-type	Mus musculus	113-134
25784372-0	2015	Attenuated acute salivary alpha-amylase responses to gustatory stimulation with citric acid in thin children.	Citric Acid	80-91	amylase alpha 1A	Homo sapiens	17-39
25784372-4	2015	To measure sAA responses to gustatory stimulation with citric acid, we used sAA ratio (the ratio of stimulated sAA levels to those of resting sAA) and investigated acute sAA responses to citric acid in children with normal (Normal-BMI, n 22) and low (Low-BMI, n 21) BMI.	Citric Acid	55-66	amylase alpha 1A	Homo sapiens	11-14
25370487-1	2015	We have recently shown that the ATP-forming SUCLA2 subunit of succinyl-CoA ligase, an enzyme of the citric acid cycle, is exclusively expressed in neurons of the human cerebral cortex; GFAP- and S100-positive astroglial cells did not exhibit immunohistoreactivity or in situ hybridization reactivity for either SUCLA2 or the GTP-forming SUCLG2.	Citric Acid	100-111	succinate-CoA ligase ADP-forming subunit beta	Homo sapiens	44-50
25370487-1	2015	We have recently shown that the ATP-forming SUCLA2 subunit of succinyl-CoA ligase, an enzyme of the citric acid cycle, is exclusively expressed in neurons of the human cerebral cortex; GFAP- and S100-positive astroglial cells did not exhibit immunohistoreactivity or in situ hybridization reactivity for either SUCLA2 or the GTP-forming SUCLG2.	Citric Acid	100-111	glial fibrillary acidic protein	Homo sapiens	185-189
25370487-1	2015	We have recently shown that the ATP-forming SUCLA2 subunit of succinyl-CoA ligase, an enzyme of the citric acid cycle, is exclusively expressed in neurons of the human cerebral cortex; GFAP- and S100-positive astroglial cells did not exhibit immunohistoreactivity or in situ hybridization reactivity for either SUCLA2 or the GTP-forming SUCLG2.	Citric Acid	100-111	succinate-CoA ligase ADP-forming subunit beta	Homo sapiens	311-317
25370487-1	2015	We have recently shown that the ATP-forming SUCLA2 subunit of succinyl-CoA ligase, an enzyme of the citric acid cycle, is exclusively expressed in neurons of the human cerebral cortex; GFAP- and S100-positive astroglial cells did not exhibit immunohistoreactivity or in situ hybridization reactivity for either SUCLA2 or the GTP-forming SUCLG2.	Citric Acid	100-111	succinate-CoA ligase GDP-forming subunit beta	Homo sapiens	337-343
25617245-2	2015	Human NaCT is relatively specific for citrate compared with other Krebs cycle intermediates.	Citric Acid	38-45	solute carrier family 13 member 5	Homo sapiens	6-10
25695203-5	2015	Here we present the first detailed structural characterization and molecular mechanics model of the interaction between a fibrillogenic protein, beta2-microglobulin, and a NP, 5 nm hydrophilic citrate-capped gold nanoparticles.	Citric Acid	193-200	beta-2-microglobulin	Homo sapiens	145-164
25628225-1	2015	The solute carrier family 13 member 5 (SLC13A5) is a sodium-coupled transporter that mediates cellular uptake of citrate, which plays important roles in the synthesis of fatty acids and cholesterol.	Citric Acid	113-120	solute carrier family 13 member 5	Homo sapiens	4-37
25628225-1	2015	The solute carrier family 13 member 5 (SLC13A5) is a sodium-coupled transporter that mediates cellular uptake of citrate, which plays important roles in the synthesis of fatty acids and cholesterol.	Citric Acid	113-120	solute carrier family 13 member 5	Homo sapiens	39-46
25652229-2	2015	The bifunctional iron-regulatory protein IRP-1 potentially regulates iron trafficking and participates in citrate metabolism as a cytosolic (c-) aconitase.	Citric Acid	106-113	aconitase 1	Rattus norvegicus	41-46
25695203-8	2015	Simulations reproduce these findings and reveal instead the role of the citrate in destabilizing the lower pH protonated form of beta2-microglobulin.	Citric Acid	72-79	beta-2-microglobulin	Homo sapiens	129-148
25450611-0	2015	Impaired cytosolic NADH shuttling and elevated UCP3 contribute to inefficient citric acid cycle flux support of postischemic cardiac work in diabetic hearts.	Citric Acid	78-89	uncoupling protein 3 (mitochondrial, proton carrier)	Mus musculus	47-51
25664849-5	2015	In prostate cancer cells, SRC-2 stimulated reductive carboxylation of alpha-ketoglutarate to generate citrate via retrograde TCA cycling, promoting lipogenesis and reprogramming of glutamine metabolism.	Citric Acid	102-109	nuclear receptor coactivator 2	Homo sapiens	26-31
25701462-1	2015	ATP citrate lyase (ACLY) is responsible for the conversion of cytosolic citrate into acetyl-CoA and oxaloacetate, and the first rate-limiting enzyme involved in de novo lipogenesis.	Citric Acid	4-11	ATP citrate lyase	Homo sapiens	19-23
25588735-6	2015	Physiological and metabolic analysis revealed that decreased PEPC activity in the ppc1/ppc2 mutant greatly reduced the synthesis of malate and citrate and severely suppressed ammonium assimilation.	Citric Acid	143-150	phosphoenolpyruvate carboxylase 1	Arabidopsis thaliana	82-86
25588735-6	2015	Physiological and metabolic analysis revealed that decreased PEPC activity in the ppc1/ppc2 mutant greatly reduced the synthesis of malate and citrate and severely suppressed ammonium assimilation.	Citric Acid	143-150	phosphoenolpyruvate carboxylase 2	Arabidopsis thaliana	87-91
25622151-1	2015	The three-component reaction between a nitrobenzene, an aldehyde, and a dienophile in the presence of iron powder as a reductant and montmorillonite K10 as a catalyst in aqueous citric acid delivers the products of an aza-Diels-Alder (Povarov) reaction with high endo-selectivity and yields up to 99%.	Citric Acid	178-189	keratin 10	Homo sapiens	149-152
25604941-7	2015	T1R1 knockout mice readily learned the aversion to dashi and generalized the aversion to sucrose, citric acid, and quinine but not to NaCl, glutamate, or any amino acid.	Citric Acid	98-109	taste receptor, type 1, member 1	Mus musculus	0-4
25713707-9	2015	Increased citrate concentration up to 6 mM further reduced the activation of C3a, C5a and sC5b-9, as well as the expression of CD11b.	Citric Acid	10-17	complement C3	Homo sapiens	77-80
25713707-9	2015	Increased citrate concentration up to 6 mM further reduced the activation of C3a, C5a and sC5b-9, as well as the expression of CD11b.	Citric Acid	10-17	complement C5a receptor 1	Homo sapiens	82-85
25713707-9	2015	Increased citrate concentration up to 6 mM further reduced the activation of C3a, C5a and sC5b-9, as well as the expression of CD11b.	Citric Acid	10-17	integrin subunit alpha M	Homo sapiens	127-132
25697682-6	2015	The mitochondrial enzyme DLST is an essential player in the citric acid cycle that warrants proper adenosine-tri-phosphate (ATP) production.	Citric Acid	60-71	dihydrolipoamide S-succinyltransferase	Danio rerio	25-29
25634685-14	2015	Aconitate hydratase 2 (ACO2), which catalyzes the conversion of citrate to isocitrate in TCA cycle, was down-regulated in animals of the high-fat group (p &lt; 0.05).	Citric Acid	64-71	aconitase 2	Homo sapiens	0-21
25367309-1	2015	ATP citrate lyase (ACLY) is a key enzyme that is involved in de novo lipogenesis by catalyzing conversion of cytosolic citrate into acetyl CoA and oxaloacetate.	Citric Acid	4-11	ATP citrate lyase	Homo sapiens	19-23
25634685-14	2015	Aconitate hydratase 2 (ACO2), which catalyzes the conversion of citrate to isocitrate in TCA cycle, was down-regulated in animals of the high-fat group (p &lt; 0.05).	Citric Acid	64-71	aconitase 2	Homo sapiens	23-27
25196033-9	2015	The apoptosis assay showed a dose-dependent increase of caspase-3 activity after administering citrate that was statistically significant.	Citric Acid	95-102	caspase 3	Mus musculus	56-65
24085565-1	2015	SUCLA2 encodes the ATP-forming beta subunit (A-SUCL-beta) of succinyl-CoA ligase, an enzyme of the citric acid cycle.	Citric Acid	99-110	succinate-CoA ligase ADP-forming subunit beta	Homo sapiens	0-6
25537655-1	2015	ATP citrate lyase (ACLY), an important enzyme involved in lipid biogenesis linked with glucose metabolism, catalyzes the conversion of citrate to oxaloacetic acid (OAA) and acetyl-CoA.	Citric Acid	4-11	ATP citrate lyase	Homo sapiens	19-23
25380696-3	2015	An excellent tool for the study of glutamine transfer from astrocytes to neurons is [(14)C]acetate or [(13)C]acetate and the glial specific enzyme inhibitors, i.e. the glutamine synthetase inhibitor methionine sulfoximine and the tricarboxylic acid cycle (aconitase) inhibitors fluoro-acetate and -citrate.	Citric Acid	297-305	glutamate-ammonia ligase	Homo sapiens	168-188
25881464-0	2015	[Effect of citric acid stimulation on salivary alpha-amylase, total protein, salivary flow rate and pH value in Pi deficiency children].	Citric Acid	11-22	amylase alpha 1A	Homo sapiens	38-60
25881464-1	2015	OBJECTIVE: To compare the effect of citric acid stimulation on salivary alpha-amylase (sAA), total protein (TP), salivary flow rate, and pH value between Pi deficiency (PD) children and healthy children, thereby providing evidence for Pi controlling saliva theory.	Citric Acid	36-47	amylase alpha 1A	Homo sapiens	63-85
25511512-4	2015	Here we report that while chemical inhibition of CTP reduces cytoplasmic citrate levels and limits breast cancer cell viability effectively, siRNA based inhibition had little effect on both.	Citric Acid	73-80	solute carrier family 25 member 1	Homo sapiens	49-52
25511512-5	2015	We also compared the effects of CTP inhibition with ACLY and found that the inhibition of ACLY reduced cytoplasmic citrate levels and limited cell viability more effectively than CTP inhibition.	Citric Acid	115-122	solute carrier family 25 member 1	Homo sapiens	32-35
25511512-5	2015	We also compared the effects of CTP inhibition with ACLY and found that the inhibition of ACLY reduced cytoplasmic citrate levels and limited cell viability more effectively than CTP inhibition.	Citric Acid	115-122	ATP citrate lyase	Homo sapiens	90-94
25966765-7	2015	In clotting filters, production of APC-PCI and PAI was also higher with heparin than citrate.	Citric Acid	85-92	serpin family E member 1	Homo sapiens	35-50
26635961-0	2015	In vitro BMP2 stimulation of osteoblast citrate production in concert with mineralized bone nodule formation.	Citric Acid	40-47	bone morphogenetic protein 2	Homo sapiens	9-13
26635961-7	2015	METHODS: The goal of this study was to determine if BMP2 promotes the development of citrate-producing osteoblasts for increased citrate incorporation in the formation of mineralized bone nodules.	Citric Acid	85-92	bone morphogenetic protein 2	Homo sapiens	52-56
26635961-7	2015	METHODS: The goal of this study was to determine if BMP2 promotes the development of citrate-producing osteoblasts for increased citrate incorporation in the formation of mineralized bone nodules.	Citric Acid	129-136	bone morphogenetic protein 2	Homo sapiens	52-56
26635961-10	2015	In addition, BMP2 increased osteoblast citrate production and incorporation in the mineralized bone nodule.	Citric Acid	39-46	bone morphogenetic protein 2	Homo sapiens	13-17
26635961-11	2015	This was accompanied by increased ZIP1 transporter, which is an essential genetic/metabolic event for citrate-producing cells.	Citric Acid	102-109	solute carrier family 39 member 1	Homo sapiens	34-38
25614306-0	2015	Expanding the Clinical Spectrum of Mitochondrial Citrate Carrier (SLC25A1) Deficiency: Facial Dysmorphism in Siblings with Epileptic Encephalopathy and Combined D,L-2-Hydroxyglutaric Aciduria.	Citric Acid	49-56	solute carrier family 25 member 1	Homo sapiens	66-73
25614306-1	2015	Recessive mutations in SLC25A1 encoding mitochondrial citrate carrier cause a rare inherited metabolic disorder, combined D,L-2-hydroxyglutaric aciduria (D,L-2-HGA), characterized by epileptic encephalopathy, respiratory insufficiency, developmental arrest and early death.	Citric Acid	54-61	solute carrier family 25 member 1	Homo sapiens	23-30
25545012-1	2014	Citrate synthase (CS), one of the key enzymes in the tricarboxylic acid (TCA) cycle, catalyzes the reaction between oxaloacetic acid and acetyl coenzyme A to generate citrate.	Citric Acid	167-174	citrate synthase	Homo sapiens	0-16
24488656-2	2015	The ratio of choline (plus spermine as the main polyamine) plus creatine over citrate [(Cho+(Spm+)Cr)/Cit] is derived from these metabolites and is used as a marker for the presence of prostate cancer.	Citric Acid	78-85	citron rho-interacting serine/threonine kinase	Homo sapiens	102-105
24488656-5	2015	These parameters influence especially the spectral shapes of citrate and spermine resonances, and consequently, the (Cho+(Spm+)Cr)/Cit ratio.	Citric Acid	61-68	citron rho-interacting serine/threonine kinase	Homo sapiens	131-134
25446200-4	2015	Our findings showed that citric acid could induce significant increase in sAA activity, total sAA amount, and glycosylated sAA amount, among which the glycosylated sAA amount had the largest response.	Citric Acid	25-36	amylase alpha 1A	Homo sapiens	74-77
25446200-4	2015	Our findings showed that citric acid could induce significant increase in sAA activity, total sAA amount, and glycosylated sAA amount, among which the glycosylated sAA amount had the largest response.	Citric Acid	25-36	amylase alpha 1A	Homo sapiens	94-97
25446200-4	2015	Our findings showed that citric acid could induce significant increase in sAA activity, total sAA amount, and glycosylated sAA amount, among which the glycosylated sAA amount had the largest response.	Citric Acid	25-36	amylase alpha 1A	Homo sapiens	94-97
25446200-4	2015	Our findings showed that citric acid could induce significant increase in sAA activity, total sAA amount, and glycosylated sAA amount, among which the glycosylated sAA amount had the largest response.	Citric Acid	25-36	amylase alpha 1A	Homo sapiens	94-97
25661822-0	2015	Changes of serum calcium, magnesium and parathyroid hormone induced by hemodialysis with citrate-enriched dialysis solution.	Citric Acid	89-96	parathyroid hormone	Homo sapiens	40-59
25661822-10	2015	CONCLUSION: Our study clearly shows that the substitution of part of acetate with citrate in dialysis solution significantly influences changes of serum calcium, magnesium and parathyroid hormone concentrations during hemodialysis and hemodiafiltration procedures.	Citric Acid	82-89	parathyroid hormone	Homo sapiens	176-195
25326241-4	2015	Citrate-suspended 20 nm AgNPs were incubated with human serum albumin (HSA), bovine serum albumin (BSA), high-density lipoprotein (HDL), or water (control) to form a PC.	Citric Acid	0-7	albumin	Rattus norvegicus	56-69
25326241-4	2015	Citrate-suspended 20 nm AgNPs were incubated with human serum albumin (HSA), bovine serum albumin (BSA), high-density lipoprotein (HDL), or water (control) to form a PC.	Citric Acid	0-7	albumin	Rattus norvegicus	84-97
25545012-1	2014	Citrate synthase (CS), one of the key enzymes in the tricarboxylic acid (TCA) cycle, catalyzes the reaction between oxaloacetic acid and acetyl coenzyme A to generate citrate.	Citric Acid	167-174	citrate synthase	Homo sapiens	18-20
25673124-1	2014	In a previous issue of Critical Care, Schilder and colleagues report the results of their multicenter trial (Citrate Anticoagulation Versus Systemic Heparinization; CASH) comparing regional anticoagulation with citrate to heparin anticoagulation.	Citric Acid	109-116	CASP8 and FADD like apoptosis regulator	Homo sapiens	165-169
25539979-1	2014	BACKGROUND: Succinate is an intermediate of the citric acid cycle as well as an extracellular circulating molecule, whose receptor, G protein-coupled receptor-91 (GPR91), was recently identified and characterized in several tissues, including heart.	Citric Acid	48-59	succinate receptor 1	Homo sapiens	163-168
25489948-2	2014	SIRT3 deacetylases and activates a large number of mitochondrial enzymes involved in the respiratory chain, in ATP production, and in both the citric acid and urea cycles.	Citric Acid	143-154	sirtuin 3	Homo sapiens	0-5
25671108-1	2014	BACKGROUND: Succinate dehydrogenase (SDH) is a mitochondrial metabolic enzyme complex involved in both the electron transport chain and the citric acid cycle.	Citric Acid	140-151	aminoadipate-semialdehyde synthase	Mus musculus	12-35
25671108-1	2014	BACKGROUND: Succinate dehydrogenase (SDH) is a mitochondrial metabolic enzyme complex involved in both the electron transport chain and the citric acid cycle.	Citric Acid	140-151	aminoadipate-semialdehyde synthase	Mus musculus	37-40
25673124-7	2014	Nevertheless, the CASH trial is the third large randomized trial showing superiority of citrate over heparin, supporting the recommendation of citrate as first choice anticoagulant.	Citric Acid	143-150	CASP8 and FADD like apoptosis regulator	Homo sapiens	18-22
25262187-8	2014	Isocitrate in milk is correlated to milk protein, fat, and citrate, and it is speculated, based on biochemistry, former studies, and the present, that isocitrate may reflect the energy situation in the mammary gland.	Citric Acid	3-10	Weaning weight-maternal milk	Bos taurus	14-18
25262187-8	2014	Isocitrate in milk is correlated to milk protein, fat, and citrate, and it is speculated, based on biochemistry, former studies, and the present, that isocitrate may reflect the energy situation in the mammary gland.	Citric Acid	3-10	casein beta	Bos taurus	36-48
25351951-4	2014	RESULTS: We found homozygous or compound heterozygous missense and frameshift mutations in the gene encoding mitochondrial aconitase (ACO2), a tricarboxylic acid cycle enzyme, catalysing interconversion of citrate into isocitrate.	Citric Acid	206-213	aconitase 2	Homo sapiens	109-132
25351951-4	2014	RESULTS: We found homozygous or compound heterozygous missense and frameshift mutations in the gene encoding mitochondrial aconitase (ACO2), a tricarboxylic acid cycle enzyme, catalysing interconversion of citrate into isocitrate.	Citric Acid	206-213	aconitase 2	Homo sapiens	134-138
25673124-1	2014	In a previous issue of Critical Care, Schilder and colleagues report the results of their multicenter trial (Citrate Anticoagulation Versus Systemic Heparinization; CASH) comparing regional anticoagulation with citrate to heparin anticoagulation.	Citric Acid	211-218	CASP8 and FADD like apoptosis regulator	Homo sapiens	165-169
25673124-7	2014	Nevertheless, the CASH trial is the third large randomized trial showing superiority of citrate over heparin, supporting the recommendation of citrate as first choice anticoagulant.	Citric Acid	88-95	CASP8 and FADD like apoptosis regulator	Homo sapiens	18-22
24444362-8	2014	This metabolic shift, associated with insulin receptor substrate-1 (IRS1)-modulated ATP-citrate lyase deregulation, resulted in higher ATP and citrate production.	Citric Acid	88-95	insulin receptor substrate 1	Homo sapiens	38-66
25194297-4	2014	Markers of oxidative stress, measured at 0.5-5 ppm exposure concentrations, indicated that caspase 3/7 activity and glutathione levels were significantly increased by both sizes of PVP-coated nanoAg and by the 75 nm citrate-coated nanoAg.	Citric Acid	216-223	caspase 3	Rattus norvegicus	91-100
24444362-8	2014	This metabolic shift, associated with insulin receptor substrate-1 (IRS1)-modulated ATP-citrate lyase deregulation, resulted in higher ATP and citrate production.	Citric Acid	88-95	insulin receptor substrate 1	Homo sapiens	68-72
25072865-6	2014	Importantly, we show that the citrate exported from mitochondria via CIC and its downstream metabolic intermediate, acetyl-coenzyme A, are necessary for TNFalpha or IFNgamma to induce nitric oxide and prostaglandin production.	Citric Acid	30-37	tumor necrosis factor	Homo sapiens	153-161
25372769-1	2014	Citric acid-based polymer/hydroxyapatite composites (CABP-HAs) are a novel class of biomimetic composites that have recently attracted significant attention in tissue engineering.	Citric Acid	0-11	S100 calcium binding protein G	Rattus norvegicus	53-57
25072865-6	2014	Importantly, we show that the citrate exported from mitochondria via CIC and its downstream metabolic intermediate, acetyl-coenzyme A, are necessary for TNFalpha or IFNgamma to induce nitric oxide and prostaglandin production.	Citric Acid	30-37	interferon gamma	Homo sapiens	165-173
25152236-1	2014	Pyruvate dehydrogenase E1alpha (PDHA1) is the first component enzyme of the pyruvate dehydrogenase (PDH) complex that transforms pyruvate, via pyruvate decarboxylation, into acetyl-CoA that is subsequently used by both the citric acid cycle and oxidative phosphorylation to generate ATP.	Citric Acid	223-234	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	0-22
25152236-1	2014	Pyruvate dehydrogenase E1alpha (PDHA1) is the first component enzyme of the pyruvate dehydrogenase (PDH) complex that transforms pyruvate, via pyruvate decarboxylation, into acetyl-CoA that is subsequently used by both the citric acid cycle and oxidative phosphorylation to generate ATP.	Citric Acid	223-234	pyruvate dehydrogenase E1 subunit alpha 1	Homo sapiens	32-37
25152236-1	2014	Pyruvate dehydrogenase E1alpha (PDHA1) is the first component enzyme of the pyruvate dehydrogenase (PDH) complex that transforms pyruvate, via pyruvate decarboxylation, into acetyl-CoA that is subsequently used by both the citric acid cycle and oxidative phosphorylation to generate ATP.	Citric Acid	223-234	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	76-98
25152236-1	2014	Pyruvate dehydrogenase E1alpha (PDHA1) is the first component enzyme of the pyruvate dehydrogenase (PDH) complex that transforms pyruvate, via pyruvate decarboxylation, into acetyl-CoA that is subsequently used by both the citric acid cycle and oxidative phosphorylation to generate ATP.	Citric Acid	223-234	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	32-35
24588850-7	2014	Noticeably, the presence of a transposon in the upstream of TaMATE1-4B in Barbela 7/72/92 seems to be responsible for its higher transcript expression where it may confer citrate efflux.	Citric Acid	171-178	protein DETOXIFICATION 42	Triticum aestivum	60-67
25061985-0	2014	Selective induction and subcellular distribution of ACONITASE 3 reveal the importance of cytosolic citrate metabolism during lipid mobilization in Arabidopsis.	Citric Acid	99-106	aconitase 3	Arabidopsis thaliana	52-63
25061985-3	2014	Characterization of knockout mutants for each of the three ACOs suggests a major role for only ACO3 in citrate metabolism.	Citric Acid	103-110	aconitase 3	Arabidopsis thaliana	95-99
25061985-4	2014	The aco3 mutant showed delayed early seedling growth, altered assimilation of [14C]acetate feeding and elevated citrate levels, which were nearly 4-fold greater than in wild-type, aco1 or aco2.	Citric Acid	112-119	aconitase 3	Arabidopsis thaliana	4-8
25061985-9	2014	We conclude that ACO3 is cytosolic in young seedlings and functions in citrate catabolism consistent with the operation of the classic glyoxylate and not direct catabolism of citrate within mitochondria.	Citric Acid	71-78	aconitase 3	Arabidopsis thaliana	17-21
24687295-3	2014	Impaired function of the mitochondrial citrate carrier (CIC) due to pathogenic mutations within the SLC25A1 gene has been identified as the underlying molecular cause of the disease.	Citric Acid	39-46	solute carrier family 25 member 1	Homo sapiens	100-107
25072865-0	2014	A key role of the mitochondrial citrate carrier (SLC25A1) in TNFalpha- and IFNgamma-triggered inflammation.	Citric Acid	32-39	solute carrier family 25 member 1	Homo sapiens	49-56
25072865-0	2014	A key role of the mitochondrial citrate carrier (SLC25A1) in TNFalpha- and IFNgamma-triggered inflammation.	Citric Acid	32-39	tumor necrosis factor	Homo sapiens	61-69
25072865-0	2014	A key role of the mitochondrial citrate carrier (SLC25A1) in TNFalpha- and IFNgamma-triggered inflammation.	Citric Acid	32-39	interferon gamma	Homo sapiens	75-83
25072865-2	2014	The mitochondrial citrate carrier (CIC), encoded by the SLC25A1 gene, promotes the export of citrate from the mitochondria to the cytoplasm, a process that profoundly influences energy balance in the cells.	Citric Acid	18-25	solute carrier family 25 member 1	Homo sapiens	56-63
25072865-2	2014	The mitochondrial citrate carrier (CIC), encoded by the SLC25A1 gene, promotes the export of citrate from the mitochondria to the cytoplasm, a process that profoundly influences energy balance in the cells.	Citric Acid	93-100	solute carrier family 25 member 1	Homo sapiens	56-63
25341358-4	2014	In healthy animals drinking tap water, oral citrate administration increased aluminum absorption and, over a 4-week period, increased aluminum deposition in brain and bone by about 2- and 20-fold, respectively.	Citric Acid	44-51	nuclear RNA export factor 1	Homo sapiens	28-31
25277207-8	2014	Levels of phosphorylated ATP-citrate Lyase (ACLY) were lower in cell lines expressing mutant CIC-S proteins compared to cells expressing wild type CIC-S, supporting a cytosolic citrate metabolism-related mechanism bof reduced clonogenicity in our in vitro model systems.	Citric Acid	29-36	ATP citrate lyase	Homo sapiens	44-48
25277207-8	2014	Levels of phosphorylated ATP-citrate Lyase (ACLY) were lower in cell lines expressing mutant CIC-S proteins compared to cells expressing wild type CIC-S, supporting a cytosolic citrate metabolism-related mechanism bof reduced clonogenicity in our in vitro model systems.	Citric Acid	29-36	capicua transcriptional repressor	Homo sapiens	93-96
25096242-2	2014	In this work, we proposed a simple in situ activation approach by dipping CdS NCs film on glass carbon electrode (CdS NCs/GCE) in an activation solution containing H2O2 and citric acid, resulting in a ~58-fold enhancement of ECL intensity in the presence of coreactant H2O2.	Citric Acid	173-184	glycine cleavage system protein H	Homo sapiens	122-125
24740690-7	2014	Moreover, hACC2 polymerization, analyzed by native page gel analysis and atomic force microscopy imaging, was allosterically regulated by citrate and the phosphorylation/dephosphorylation modulated citrate-induced hACC2 polymerization process.	Citric Acid	138-145	acetyl-CoA carboxylase beta	Homo sapiens	10-15
24740690-7	2014	Moreover, hACC2 polymerization, analyzed by native page gel analysis and atomic force microscopy imaging, was allosterically regulated by citrate and the phosphorylation/dephosphorylation modulated citrate-induced hACC2 polymerization process.	Citric Acid	198-205	acetyl-CoA carboxylase beta	Homo sapiens	10-15
24740690-7	2014	Moreover, hACC2 polymerization, analyzed by native page gel analysis and atomic force microscopy imaging, was allosterically regulated by citrate and the phosphorylation/dephosphorylation modulated citrate-induced hACC2 polymerization process.	Citric Acid	198-205	acetyl-CoA carboxylase beta	Homo sapiens	214-219
25214198-6	2014	Effect of metabolites, as exemplified by certain metabolites such as lactate, citrate, sarcosine, metabolites of arachidonic acid on angiogenesis through the regulation of expression of VEGF as well as its angiogenic potential through polyADP ribosylation is discussed.	Citric Acid	78-85	vascular endothelial growth factor A	Homo sapiens	186-190
24948467-1	2014	Citrate synthase (CS) catalyses the entry of carbon into the citric acid cycle and is highly-conserved structurally across the tree of life.	Citric Acid	61-72	citrate synthase	Homo sapiens	0-16
24948467-1	2014	Citrate synthase (CS) catalyses the entry of carbon into the citric acid cycle and is highly-conserved structurally across the tree of life.	Citric Acid	61-72	citrate synthase	Homo sapiens	18-20
32481889-1	2014	Water dispersible Gd3+,Yb3+,Er3+ and Gd3+,Yb3+,Tm3+ doped CaF2 nanoparticles (NPs) were prepared by one-pot hydrothermal synthesis using citrate ions as capping agents without the need for any post-synthesis reaction.	Citric Acid	137-144	CCR4-NOT transcription complex subunit 8	Homo sapiens	58-62
25256100-6	2014	This deficit was caused by Lkb1-regulated diminished production of the mitochondrial Krebs cycle substrate citrate, a precursor to cellular lipids.	Citric Acid	107-114	serine/threonine kinase 11	Mus musculus	27-31
25256100-8	2014	Restoring citrate partially rescued Lkb1-mutant SC defects.	Citric Acid	10-17	serine/threonine kinase 11	Mus musculus	36-40
24712822-12	2014	Astaxanthin administration was more effective than citrate treatment in reducing crystal deposition and down-regulating the expression of OPN and TGF-beta1.	Citric Acid	51-58	transforming growth factor, beta 1	Rattus norvegicus	146-155
24845712-7	2014	RESULTS: OPG concentrations were significantly lower (p&lt;0.0001) in serum (1015+-357 pg/mL) than in all plasma samples (1314+-448 pg/mL in EDTA, 1209+-417 pg/mL in heparin and 1260+-498 pg/mL in citrate).	Citric Acid	197-204	TNF receptor superfamily member 11b	Homo sapiens	9-12
24954417-1	2014	Disorders arising from impaired assembly of succinate dehydrogenase (SDH) result in a myriad of pathologies, consistent with its unique role in linking the citric acid cycle and electron transport chain.	Citric Acid	156-167	Sorbitol dehydrogenase-2	Drosophila melanogaster	69-72
24819445-3	2014	In this work we report that changes observed in the expression of the lipogenic enzymes acetyl-CoA carboxylase and fatty acid synthase were associated with a decrease in the activity of citrate carrier (CIC), a protein of the inner mitochondrial membrane closely related to hepatic lipogenesis.	Citric Acid	186-193	fatty acid synthase	Rattus norvegicus	115-134
24712822-10	2014	Astaxanthin treatment was more effective than citrate administration in the regulation of renal ACE levels, OPN and TGF-beta1 expressions.	Citric Acid	46-53	angiotensin I converting enzyme	Rattus norvegicus	96-99
24712822-10	2014	Astaxanthin treatment was more effective than citrate administration in the regulation of renal ACE levels, OPN and TGF-beta1 expressions.	Citric Acid	46-53	secreted phosphoprotein 1	Rattus norvegicus	108-111
24712822-10	2014	Astaxanthin treatment was more effective than citrate administration in the regulation of renal ACE levels, OPN and TGF-beta1 expressions.	Citric Acid	46-53	transforming growth factor, beta 1	Rattus norvegicus	116-125
24712822-12	2014	Astaxanthin administration was more effective than citrate treatment in reducing crystal deposition and down-regulating the expression of OPN and TGF-beta1.	Citric Acid	51-58	secreted phosphoprotein 1	Rattus norvegicus	138-141
24850836-4	2014	The (14)C-citrate efflux experiments in oocytes demonstrated that BoMATE is a citrate transporter.	Citric Acid	10-17	MATE efflux family protein 1-like	Brassica oleracea	66-72
25052436-4	2014	High and significant correlations among the concentrations of lactose, glucose, glucose-6-posphate, milk related respiratory index (the ratio between the concentrations of citrate/lactate+malate in milk) and milk-derived glycolytic index (the ratio between glucose-6-phosphate and glucose in milk) and milk clotting parameters were found.	Citric Acid	172-179	Weaning weight-maternal milk	Bos taurus	100-104
25052436-4	2014	High and significant correlations among the concentrations of lactose, glucose, glucose-6-posphate, milk related respiratory index (the ratio between the concentrations of citrate/lactate+malate in milk) and milk-derived glycolytic index (the ratio between glucose-6-phosphate and glucose in milk) and milk clotting parameters were found.	Citric Acid	172-179	Weaning weight-maternal milk	Bos taurus	198-202
25052436-4	2014	High and significant correlations among the concentrations of lactose, glucose, glucose-6-posphate, milk related respiratory index (the ratio between the concentrations of citrate/lactate+malate in milk) and milk-derived glycolytic index (the ratio between glucose-6-phosphate and glucose in milk) and milk clotting parameters were found.	Citric Acid	172-179	Weaning weight-maternal milk	Bos taurus	198-202
25052436-4	2014	High and significant correlations among the concentrations of lactose, glucose, glucose-6-posphate, milk related respiratory index (the ratio between the concentrations of citrate/lactate+malate in milk) and milk-derived glycolytic index (the ratio between glucose-6-phosphate and glucose in milk) and milk clotting parameters were found.	Citric Acid	172-179	Weaning weight-maternal milk	Bos taurus	198-202
25052436-4	2014	High and significant correlations among the concentrations of lactose, glucose, glucose-6-posphate, milk related respiratory index (the ratio between the concentrations of citrate/lactate+malate in milk) and milk-derived glycolytic index (the ratio between glucose-6-phosphate and glucose in milk) and milk clotting parameters were found.	Citric Acid	172-179	Weaning weight-maternal milk	Bos taurus	198-202
24850836-7	2014	Compared with the wild-type Arabidopsis, the transgenic lines constitutively overexpressing BoMATE enhanced Al tolerance and increased citrate secretion.	Citric Acid	135-142	MATE efflux family protein 1-like	Brassica oleracea	92-98
24778178-3	2014	Here we report crystal structures of ALKBH5 in the presence of either its cofactors or the ALKBH5 inhibitor citrate.	Citric Acid	108-115	alkB homolog 5, RNA demethylase	Homo sapiens	37-43
24995870-5	2014	Analysis of rare variants in genes consistent with an autosomal-recessive mode of inheritance led to identification of mutations in SLC13A5, which encodes the cytoplasmic sodium-dependent citrate carrier, notably expressed in neurons.	Citric Acid	188-195	solute carrier family 13 member 5	Homo sapiens	132-139
24778178-3	2014	Here we report crystal structures of ALKBH5 in the presence of either its cofactors or the ALKBH5 inhibitor citrate.	Citric Acid	108-115	alkB homolog 5, RNA demethylase	Homo sapiens	91-97
24755473-0	2014	IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism.	Citric Acid	21-32	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-4
24935220-12	2014	CONCLUSIONS: MiR-26a regulates glucose metabolism of colorectal cancer cells by direct targeting the PDHX, which inhibits the conversion of pyruvate to acetyl coenzyme A in the citric acid cycle.	Citric Acid	177-188	microRNA 26a-1	Homo sapiens	13-20
24935220-12	2014	CONCLUSIONS: MiR-26a regulates glucose metabolism of colorectal cancer cells by direct targeting the PDHX, which inhibits the conversion of pyruvate to acetyl coenzyme A in the citric acid cycle.	Citric Acid	177-188	pyruvate dehydrogenase complex component X	Homo sapiens	101-105
24819048-5	2014	In the present study, we demonstrate in vitro direct functional activation of TRPA1 receptor by citric acid which is routinely used to evoke cough in preclinical and clinical studies.	Citric Acid	96-107	transient receptor potential cation channel subfamily A member 1	Cavia porcellus	78-83
24857658-2	2014	In contrast, hypoxia and other impairments of mitochondrial function induce an alternative pathway that produces citrate by reductively carboxylating alpha-ketoglutarate (AKG) via NADPH-dependent isocitrate dehydrogenase (IDH).	Citric Acid	113-120	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	222-225
24216261-4	2014	The presence of malic and citric acids significantly decreased the immobilizationefficiency of Pb(II) by HAp1 and PR, clarifying the lower adsorption affinities of Pb(II)-organic acid complexes on HAp1 and PR rather than Pb(II) ion.	Citric Acid	26-38	submaxillary gland androgen regulated protein 3B	Homo sapiens	95-101
24216261-4	2014	The presence of malic and citric acids significantly decreased the immobilizationefficiency of Pb(II) by HAp1 and PR, clarifying the lower adsorption affinities of Pb(II)-organic acid complexes on HAp1 and PR rather than Pb(II) ion.	Citric Acid	26-38	huntingtin associated protein 1	Homo sapiens	105-109
24216261-4	2014	The presence of malic and citric acids significantly decreased the immobilizationefficiency of Pb(II) by HAp1 and PR, clarifying the lower adsorption affinities of Pb(II)-organic acid complexes on HAp1 and PR rather than Pb(II) ion.	Citric Acid	26-38	huntingtin associated protein 1	Homo sapiens	197-201
24604252-3	2014	The enzymes 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) and glutaminase-1 (GLS1) maintain a high abundance in glycolytic intermediates (for synthesis of non-essential amino acids, the use of ribose for the synthesis of nucleotides and hexosamine biosynthesis), as well as tricarboxylic acid cycle intermediates (replenishing the loss of mitochondrial citrate), respectively.	Citric Acid	370-377	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	12-65
24604252-3	2014	The enzymes 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) and glutaminase-1 (GLS1) maintain a high abundance in glycolytic intermediates (for synthesis of non-essential amino acids, the use of ribose for the synthesis of nucleotides and hexosamine biosynthesis), as well as tricarboxylic acid cycle intermediates (replenishing the loss of mitochondrial citrate), respectively.	Citric Acid	370-377	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	67-73
24604252-3	2014	The enzymes 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) and glutaminase-1 (GLS1) maintain a high abundance in glycolytic intermediates (for synthesis of non-essential amino acids, the use of ribose for the synthesis of nucleotides and hexosamine biosynthesis), as well as tricarboxylic acid cycle intermediates (replenishing the loss of mitochondrial citrate), respectively.	Citric Acid	370-377	glutaminase	Homo sapiens	79-92
24604252-3	2014	The enzymes 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) and glutaminase-1 (GLS1) maintain a high abundance in glycolytic intermediates (for synthesis of non-essential amino acids, the use of ribose for the synthesis of nucleotides and hexosamine biosynthesis), as well as tricarboxylic acid cycle intermediates (replenishing the loss of mitochondrial citrate), respectively.	Citric Acid	370-377	glutaminase	Homo sapiens	94-98
24808185-5	2014	In addition to citric acid cycle intermediates such as alpha-ketoglutarate and succinate, NaDC3 transports other compounds into cells, including N-acetyl aspartate, mercaptosuccinate, and glutathione, in keeping with its dual roles in cell nutrition and detoxification.	Citric Acid	15-26	solute carrier family 13 member 3	Homo sapiens	90-95
24398694-7	2014	Sonication also enhanced solute crystallization in tartaric (200 mM; pH 5), citric (200 mM pH 4) and malic (200 mM; pH 4) acid buffers.	Citric Acid	76-82	prolyl 4-hydroxylase, transmembrane	Homo sapiens	91-95
24657347-5	2014	By analyzing maximum in vitro enzyme activities we found low activities of pyruvate dehydrogenase and pyruvate carboxylase which suggest a reduced metabolite transfer into the citric acid cycle resulting in lactate release (Warburg effect).	Citric Acid	176-187	pyruvate carboxylase	Homo sapiens	102-122
24819048-6	2014	We also show for the first time that a potent and selective TRPA1 antagonist GRC 17536 inhibits citric acid induced cellular Ca(+2) influx in TRPA1 expressing cells and the citric acid induced cough response in guinea pigs.	Citric Acid	96-107	transient receptor potential cation channel subfamily A member 1	Cavia porcellus	60-65
24819048-6	2014	We also show for the first time that a potent and selective TRPA1 antagonist GRC 17536 inhibits citric acid induced cellular Ca(+2) influx in TRPA1 expressing cells and the citric acid induced cough response in guinea pigs.	Citric Acid	96-107	transient receptor potential cation channel subfamily A member 1	Cavia porcellus	142-147
24819048-6	2014	We also show for the first time that a potent and selective TRPA1 antagonist GRC 17536 inhibits citric acid induced cellular Ca(+2) influx in TRPA1 expressing cells and the citric acid induced cough response in guinea pigs.	Citric Acid	173-184	transient receptor potential cation channel subfamily A member 1	Cavia porcellus	60-65
24819048-7	2014	Hence our data provides a mechanistic link between TRPA1 receptor activation in vitro and cough response induced in vivo by citric acid.	Citric Acid	124-135	transient receptor potential cation channel subfamily A member 1	Cavia porcellus	51-56
24631175-5	2014	CONCLUSIONS: The change from NaF to citrate tubes caused higher glucose values, and consequently more glucose determinations above the decision limit for diabetes.	Citric Acid	36-43	C-X-C motif chemokine ligand 8	Homo sapiens	29-32
24626348-6	2014	Importantly, our further analyses identified that HIF-1alpha protein downregulation induced by short-term GS-HCl treatment was blunted by exogenous administration of the citric acid cycle metabolites citrate and 2-oxoglutarate, but not the glycolytic end byproducts pyruvate and lactate.	Citric Acid	170-181	hypoxia inducible factor 1 subunit alpha	Homo sapiens	50-60
24626348-6	2014	Importantly, our further analyses identified that HIF-1alpha protein downregulation induced by short-term GS-HCl treatment was blunted by exogenous administration of the citric acid cycle metabolites citrate and 2-oxoglutarate, but not the glycolytic end byproducts pyruvate and lactate.	Citric Acid	200-207	hypoxia inducible factor 1 subunit alpha	Homo sapiens	50-60
24626348-7	2014	These findings demonstrate firstly that short-term GS treatment selectively downregulates HIF-1alpha at the protein level in YD-8 cells via interference of production of the citric acid cycle metabolites.	Citric Acid	174-185	hypoxia inducible factor 1 subunit alpha	Homo sapiens	90-100
24433072-7	2014	The administration of citric acid (1-2 g/kg) attenuated LPS-induced elevations in brain MDA, nitrite, TNF-alpha, GPx, and PON1 activity.	Citric Acid	22-33	tumor necrosis factor	Mus musculus	102-111
24433072-7	2014	The administration of citric acid (1-2 g/kg) attenuated LPS-induced elevations in brain MDA, nitrite, TNF-alpha, GPx, and PON1 activity.	Citric Acid	22-33	paraoxonase 1	Mus musculus	122-126
24433072-9	2014	GPx activity was increased, while PON1 activity was decreased by citric acid.	Citric Acid	65-76	paraoxonase 1	Mus musculus	34-38
24433072-10	2014	The LPS-induced liver injury, DNA fragmentation, serum transaminase elevations, caspase-3, and inducible nitric oxide synthase expression were attenuated by 1-2 g/kg citric acid.	Citric Acid	166-177	caspase 3	Mus musculus	80-89
24734634-2	2014	The BCS nanopowders were prepared with various molar ratio of citric acid to metal nitrate.	Citric Acid	62-73	BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone	Homo sapiens	4-7
24720842-1	2014	The enzyme citrate synthase is used by all living cells to catalyze the first step of the citric acid cycle.	Citric Acid	90-101	citrate synthase	Homo sapiens	11-27
24434492-3	2014	We have demonstrated that a protein (cytochrome c (Cytc c) or bovine serum albumin (BSA)) can be employed to gate fluorescence resonance energy transfer occurring from a fluorescein isothiocyanate fluorescent dye to plasmonic citrate-capped gold nanoparticles.	Citric Acid	226-233	cytochrome c, somatic	Homo sapiens	37-49
24434492-3	2014	We have demonstrated that a protein (cytochrome c (Cytc c) or bovine serum albumin (BSA)) can be employed to gate fluorescence resonance energy transfer occurring from a fluorescein isothiocyanate fluorescent dye to plasmonic citrate-capped gold nanoparticles.	Citric Acid	226-233	cytochrome c, somatic	Homo sapiens	51-57
24773569-3	2014	In this Article, we focus on the "reaction products" of a widely known nanoparticle type, citrate-capped 30 nm gold nanospheres, with a model protein, horse myoglobin.	Citric Acid	90-97	myoglobin	Equus caballus	157-166
24755339-10	2014	Concentrations of NGAL in the ultrafiltrate were lower with citrate-based CVVH (P = 0.03) and decreased over time, irrespective of anticoagulation administered (P &lt; 0.001).	Citric Acid	60-67	lipocalin 2	Homo sapiens	18-22
24469453-6	2014	ACLY produces cytosolic acetyl-CoA from mitochondrially derived citrate.	Citric Acid	64-71	ATP citrate lyase	Mus musculus	0-4
32261517-7	2014	BCC and insulin formed supramolecular aggregates with significantly different morphologies depending on the buffer species used: a network structure in acetate buffer, nanoparticles in citrate buffer, and large aggregates in phosphate buffer.	Citric Acid	185-192	insulin	Homo sapiens	8-15
24291138-2	2014	The degradation of parabens increased with decreasing pH within the range of 5.0-8.0 at the Fe(III)-to-citrate ratio of 10:150 (muM).	Citric Acid	103-110	latexin	Homo sapiens	128-131
24222346-4	2014	The current study revealed that mIndy expression and [(14)C]-citrate uptake was induced by physiological concentrations of glucagon via a cAMP-dependent and cAMP-responsive element-binding protein (CREB)-dependent mechanism in primary rat hepatocytes.	Citric Acid	61-68	cAMP responsive element binding protein 1	Rattus norvegicus	198-202
24587533-7	2014	The paneer samples made with citric acid and tartaric acid had significantly higher (P &lt;= 0.05) values for fat, protein, ash, total solids recovery, fat on dry matter basis, body and texture and overall acceptability scores than paneer made with malic acid at all concentrations.	Citric Acid	29-40	FAT atypical cadherin 1	Homo sapiens	110-113
24587533-7	2014	The paneer samples made with citric acid and tartaric acid had significantly higher (P &lt;= 0.05) values for fat, protein, ash, total solids recovery, fat on dry matter basis, body and texture and overall acceptability scores than paneer made with malic acid at all concentrations.	Citric Acid	29-40	FAT atypical cadherin 1	Homo sapiens	152-155
24356238-6	2014	Citrate-reduced silver nanoparticles were used as SERS substrate and these nanoparticles were functionalized using 1-butanethiol.	Citric Acid	0-7	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	50-54
24445252-13	2014	GC/MS analysis with universally-labeled (13)C-glucose in adult worms further showed significantly increased isotopic enrichment in lactate, citrate, and malate species in the complex I (gas-1) mutant.	Citric Acid	140-147	putative NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	Caenorhabditis elegans	186-191
24183442-3	2014	In the current study, we address this problem through the complete ligand transformation of CdTe QDs from toxic thiolglycolic acid (TGA) to green citrate, which is attributed to the Cd-S bond breaking and the Au-S bond formation.	Citric Acid	146-153	CDP-diacylglycerol synthase 1	Homo sapiens	182-186
24433428-10	2014	CONCLUSIONS: CAMH and Lutrol have different reactivities towards venlafaxine HCl and also different plasticising mechanisms for Eudragit RSPO because of hydrogen bonding and because of similar overall molecular attractive forces, respectively.	Citric Acid	13-17	R-spondin 1	Homo sapiens	137-141
24419633-1	2014	Human fumarase (HsFH) is a well-known citric acid cycle enzyme and is therefore a key component in energy metabolism.	Citric Acid	38-49	fumarate hydratase	Homo sapiens	6-14
24666349-1	2014	Staphylococcus aureus elaborates two citrate-containing siderophores, staphyloferrin A (SA) and staphyloferrin B (SB), that enhance growth under iron-restriction, yet, paradoxically, expression of the TCA cycle citrate synthase, CitZ, is downregulated during iron starvation.	Citric Acid	37-44	AT695_RS09050	Staphylococcus aureus	211-227
24342687-8	2014	As involution advanced, the Na(+):K(+) ratio increased, whereas the citrate:lactoferrin ratio decreased.	Citric Acid	68-75	lactotransferrin	Bos taurus	76-87
24252724-4	2014	We found that CCl4 caused a significant increase in lactate, succinate, citrate, dimethylgycine, choline and taurine.	Citric Acid	72-79	C-C motif chemokine ligand 4	Rattus norvegicus	14-18
24401421-5	2014	Analysis of these parameters for the system gives evidence that HSA molecules are very likely to be attached to AuNPs surface predominantly as a flat monolayer to form a stable AuNPs-HSA conjugate with a core-shell structure, and the binding process takes place mainly through electrostatic and hydrogen-bond interactions between the positively amino acid residues of HSA and the negatively carboxyl group of citrate on AuNPs surface.	Citric Acid	409-416	albumin	Homo sapiens	64-67
24395786-8	2014	The higher levels of citric acid cycle intermediates found in the mitochondria of siUCP2-HepG2 cells compared with those found in wild-type cells in addition to the transport data indicate that, by exporting C4 compounds out of mitochondria, UCP2 limits the oxidation of acetyl-CoA-producing substrates such as glucose and enhances glutaminolysis, preventing the mitochondrial accumulation of C4 metabolites derived from glutamine.	Citric Acid	21-32	uncoupling protein 2	Homo sapiens	84-88
24634330-16	2014	With citrate the levels of ANGPTL4 decreased.	Citric Acid	5-12	angiopoietin like 4	Homo sapiens	27-34
24688728-2	2013	Indy and its mammalian homolog mINDY (Slc 3a5, NaCT) are transporters of TCA cycle intermediates, mainly handling the uptake of citrate via the plasma membrane into the cytosol.	Citric Acid	128-135	solute carrier family 13 (sodium-dependent citrate transporter), member 5	Mus musculus	0-4
26870663-0	2014	Mutations in the Mitochondrial Citrate Carrier SLC25A1 are Associated with Impaired Neuromuscular Transmission.	Citric Acid	31-38	solute carrier family 25 member 1	Homo sapiens	47-54
26870663-5	2014	RESULTS: We identified a novel homozygous missense mutation in the SLC25A1 gene, encoding the mitochondrial citrate carrier.	Citric Acid	108-115	solute carrier family 25 member 1	Homo sapiens	67-74
25745519-8	2014	The up-regulation of zinc uptake transporter ZIP1 is essential for the manifestation of the citrate-producing capability of the osteoblasts.	Citric Acid	92-99	solute carrier family 39 member 1	Homo sapiens	45-49
24114175-5	2014	NaDC1, primarily found on the apical membranes of renal proximal tubule and small intestinal cells, is involved in regulating urinary levels of citrate and plays a role in kidney stone development.	Citric Acid	144-151	solute carrier family 13 member 2	Homo sapiens	0-5
24688728-2	2013	Indy and its mammalian homolog mINDY (Slc 3a5, NaCT) are transporters of TCA cycle intermediates, mainly handling the uptake of citrate via the plasma membrane into the cytosol.	Citric Acid	128-135	solute carrier family 13 (sodium-dependent citrate transporter), member 5	Mus musculus	31-36
24688728-2	2013	Indy and its mammalian homolog mINDY (Slc 3a5, NaCT) are transporters of TCA cycle intermediates, mainly handling the uptake of citrate via the plasma membrane into the cytosol.	Citric Acid	128-135	solute carrier family 13 member 5	Homo sapiens	47-51
24688728-3	2013	Deletion of mINDY in mice leads to significant metabolic changes akin to caloric restriction, likely caused by reducing the effects of mINDY-imported citrate on fatty acid and cholesterol synthesis, glucose metabolism and ss-oxidation.	Citric Acid	150-157	solute carrier family 13 (sodium-dependent citrate transporter), member 5	Mus musculus	12-17
24688728-3	2013	Deletion of mINDY in mice leads to significant metabolic changes akin to caloric restriction, likely caused by reducing the effects of mINDY-imported citrate on fatty acid and cholesterol synthesis, glucose metabolism and ss-oxidation.	Citric Acid	150-157	solute carrier family 13 (sodium-dependent citrate transporter), member 5	Mus musculus	135-140
24304688-11	2013	The biological relevance of the control of glutamine metabolism genes by the PGC-1alpha/ERRalpha axis is demonstrated by consequent regulation of glutamine flux through the citric acid cycle.	Citric Acid	173-184	PPARG coactivator 1 alpha	Homo sapiens	77-87
24304688-11	2013	The biological relevance of the control of glutamine metabolism genes by the PGC-1alpha/ERRalpha axis is demonstrated by consequent regulation of glutamine flux through the citric acid cycle.	Citric Acid	173-184	estrogen related receptor alpha	Homo sapiens	88-96
24304688-12	2013	PGC-1alpha and ERRalpha regulate both the canonical citric acid cycle (forward) and the reductive carboxylation (reverse) fluxes; the latter can be used to support de novo lipogenesis reactions, most notably in hypoxic conditions.	Citric Acid	52-63	PPARG coactivator 1 alpha	Homo sapiens	0-10
24304688-12	2013	PGC-1alpha and ERRalpha regulate both the canonical citric acid cycle (forward) and the reductive carboxylation (reverse) fluxes; the latter can be used to support de novo lipogenesis reactions, most notably in hypoxic conditions.	Citric Acid	52-63	estrogen related receptor alpha	Homo sapiens	15-23
24024967-4	2013	This article, a companion to a previous one (Boulton, 2013, Submitted for publication), describes in more detail how they recognised a potential for chemical anticoagulants which led to the introduction for a short period of sodium phosphate to aid blood transfusion: these cases preceded the introduction of citrate (Mollison, 2000, British Journal of Haematology, 108, 13-18).	Citric Acid	309-316	activation induced cytidine deaminase	Homo sapiens	245-248
24367243-5	2013	RESULTS: In citrate OL-HDF pretreatment plasma levels of C-reactive protein and beta 2-microglobulin were significantly reduced; intra-treatment plasma acetate levels increased in the former technique and decreased in the latter.	Citric Acid	12-19	beta-2-microglobulin	Homo sapiens	80-100
24277613-6	2013	Citrate-induced polymerization and enzymatic activity of ACC2 were restrained by the addition of the recombinant Spot14/Mig12 heterocomplex but only partially by the oligo-heterocomplex, demonstrating that the heterocomplex is a designated metabolic inhibitor of human ACC2.	Citric Acid	0-7	acetyl-CoA carboxylase beta	Homo sapiens	57-61
24277613-6	2013	Citrate-induced polymerization and enzymatic activity of ACC2 were restrained by the addition of the recombinant Spot14/Mig12 heterocomplex but only partially by the oligo-heterocomplex, demonstrating that the heterocomplex is a designated metabolic inhibitor of human ACC2.	Citric Acid	0-7	thyroid hormone responsive	Homo sapiens	113-119
24277613-6	2013	Citrate-induced polymerization and enzymatic activity of ACC2 were restrained by the addition of the recombinant Spot14/Mig12 heterocomplex but only partially by the oligo-heterocomplex, demonstrating that the heterocomplex is a designated metabolic inhibitor of human ACC2.	Citric Acid	0-7	MID1 interacting protein 1	Homo sapiens	120-125
24277613-6	2013	Citrate-induced polymerization and enzymatic activity of ACC2 were restrained by the addition of the recombinant Spot14/Mig12 heterocomplex but only partially by the oligo-heterocomplex, demonstrating that the heterocomplex is a designated metabolic inhibitor of human ACC2.	Citric Acid	0-7	acetyl-CoA carboxylase beta	Homo sapiens	269-273
24171660-6	2013	For PAH/citrate, the film growth rate reaches a plateau value when the spraying rate of citrate is increased while that of PAH is maintained constant, whereas when the spraying rate of citrate is maintained constant and that of PAH is increased, a behavior similar to that of PAH/CD-S is observed.	Citric Acid	8-15	phenylalanine hydroxylase	Homo sapiens	4-7
24171660-6	2013	For PAH/citrate, the film growth rate reaches a plateau value when the spraying rate of citrate is increased while that of PAH is maintained constant, whereas when the spraying rate of citrate is maintained constant and that of PAH is increased, a behavior similar to that of PAH/CD-S is observed.	Citric Acid	8-15	phenylalanine hydroxylase	Homo sapiens	123-126
24171660-6	2013	For PAH/citrate, the film growth rate reaches a plateau value when the spraying rate of citrate is increased while that of PAH is maintained constant, whereas when the spraying rate of citrate is maintained constant and that of PAH is increased, a behavior similar to that of PAH/CD-S is observed.	Citric Acid	8-15	phenylalanine hydroxylase	Homo sapiens	123-126
24171660-6	2013	For PAH/citrate, the film growth rate reaches a plateau value when the spraying rate of citrate is increased while that of PAH is maintained constant, whereas when the spraying rate of citrate is maintained constant and that of PAH is increased, a behavior similar to that of PAH/CD-S is observed.	Citric Acid	8-15	phenylalanine hydroxylase	Homo sapiens	123-126
24171660-6	2013	For PAH/citrate, the film growth rate reaches a plateau value when the spraying rate of citrate is increased while that of PAH is maintained constant, whereas when the spraying rate of citrate is maintained constant and that of PAH is increased, a behavior similar to that of PAH/CD-S is observed.	Citric Acid	88-95	phenylalanine hydroxylase	Homo sapiens	4-7
24171660-8	2013	For PAH/citrate, by increasing the PAH/citrate spraying rate ratio, the carboxylic/nitrogen ratio in the film increases and tends to 1.	Citric Acid	8-15	phenylalanine hydroxylase	Homo sapiens	4-7
24171660-8	2013	For PAH/citrate, by increasing the PAH/citrate spraying rate ratio, the carboxylic/nitrogen ratio in the film increases and tends to 1.	Citric Acid	8-15	phenylalanine hydroxylase	Homo sapiens	35-38
24171660-8	2013	For PAH/citrate, by increasing the PAH/citrate spraying rate ratio, the carboxylic/nitrogen ratio in the film increases and tends to 1.	Citric Acid	39-46	phenylalanine hydroxylase	Homo sapiens	4-7
24171660-8	2013	For PAH/citrate, by increasing the PAH/citrate spraying rate ratio, the carboxylic/nitrogen ratio in the film increases and tends to 1.	Citric Acid	39-46	phenylalanine hydroxylase	Homo sapiens	35-38
24171660-12	2013	A model based on strong (respectively weak) interactions between PAH and CD-S (respectively citrate) is proposed to explain these features.	Citric Acid	92-99	phenylalanine hydroxylase	Homo sapiens	65-68
24171660-12	2013	A model based on strong (respectively weak) interactions between PAH and CD-S (respectively citrate) is proposed to explain these features.	Citric Acid	92-99	CDP-diacylglycerol synthase 1	Homo sapiens	73-77
24070486-1	2013	In this contribution, we demonstrated a novel colorimetric method for highly sensitive and accurate detection of iodide using citrate-stabilized silver triangular nanoplates (silver TNPs).	Citric Acid	126-133	C1GALT1 specific chaperone 1	Homo sapiens	182-186
24064771-0	2013	Citrate induces apoptosis of the acute monocytic leukemia U937 cell line through regulation of HIF-1alpha signaling.	Citric Acid	0-7	hypoxia inducible factor 1 subunit alpha	Homo sapiens	95-105
24064771-3	2013	The results showed that citrate inhibits the expression of Bcl-2, while it induces the activation of caspases-3 and -9.	Citric Acid	24-31	BCL2 apoptosis regulator	Homo sapiens	59-64
24064771-3	2013	The results showed that citrate inhibits the expression of Bcl-2, while it induces the activation of caspases-3 and -9.	Citric Acid	24-31	caspase 3	Homo sapiens	101-118
24064771-4	2013	In addition, citrate induces U937 apoptosis in a dose- and time-dependent manner by regulating the expression of HIF-1alpha and its downstream target GLUT-1.	Citric Acid	13-20	hypoxia inducible factor 1 subunit alpha	Homo sapiens	113-123
24064771-4	2013	In addition, citrate induces U937 apoptosis in a dose- and time-dependent manner by regulating the expression of HIF-1alpha and its downstream target GLUT-1.	Citric Acid	13-20	solute carrier family 2 member 1	Homo sapiens	150-156
24064771-5	2013	The results suggest that citrate performs an anti-acute monocytic leukemia action by targeting HIF-1alpha signaling and may be a promising clinical approach.	Citric Acid	25-32	hypoxia inducible factor 1 subunit alpha	Homo sapiens	95-105
23876293-2	2013	IDH3 is mitochondrial, uses NAD(H) and was believed to be the IDH that supports the citric acid cycle.	Citric Acid	84-95	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-3
23876293-5	2013	Cellular levels of citrate, alpha-ketoglutarate, malate and ATP were altered in patterns consistent with blockage at the mitochondrial IDH reactions.	Citric Acid	19-26	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	135-138
23876293-9	2013	The results also indicate that IDH2 can support the citric acid cycle.	Citric Acid	52-63	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	31-35
24101491-3	2013	We here report the crystal structures of Mincle, MCL, and the Mincle-citric acid complex.	Citric Acid	69-80	C-type lectin domain family 4 member E	Homo sapiens	41-47
24101491-3	2013	We here report the crystal structures of Mincle, MCL, and the Mincle-citric acid complex.	Citric Acid	69-80	C-type lectin domain family 4 member E	Homo sapiens	62-68
24123010-7	2013	Citric acid increased the level of Bcl-2-associated X protein (BAX) and reduced the levels of B-cell lymphoma-2 (BCL-2), B-cell lymphoma-extra large (BCL-XL) and activated caspase-9 and caspase-3, which subsequently induced apoptosis via caspase-dependent and caspase-independent pathways.	Citric Acid	0-11	BCL2 associated X, apoptosis regulator	Homo sapiens	35-61
24103422-0	2013	Inhibition of Mcl-1 expression by citrate enhances the effect of Bcl-xL inhibitors on human ovarian carcinoma cells.	Citric Acid	34-41	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	14-19
24103422-0	2013	Inhibition of Mcl-1 expression by citrate enhances the effect of Bcl-xL inhibitors on human ovarian carcinoma cells.	Citric Acid	34-41	BCL2 like 1	Homo sapiens	65-71
24103422-2	2013	We have studied their concomitant inhibition, using ABT 737 or siRNA targeting XL1 and citrate, a molecule which reduces the expression level of Mcl-1.Two cisplatin-chemoresistant ovarian cell lines (SKOV3 and IGROV1-R10) were exposed to ABT 737 or siRNA targeting XL1 and citrate at various individual concentrations, or combined.	Citric Acid	87-94	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	145-150
24103422-4	2013	Western blot analyses were performed to detect various proteins implied in apoptotic cell death pathways.Mcl-1 expression was barely reduced when cells were exposed to citrate alone, whereas a mild reduction was observed after ABT 737 treatment.	Citric Acid	168-175	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	105-110
24103422-5	2013	Concomitant inhibition of Bcl-xL and Mcl-1 using ABT 737 or siXL1 associated with citrate was far more effective in inhibiting cell proliferation and inducing cell death than treatment alone.Given that few, if any, specific inhibitors of Mcl-1 are currently available, anti-glycolytic agents such as citrate could be tested in association with synthetic inhibitors of Bcl-xL.	Citric Acid	82-89	BCL2 like 1	Homo sapiens	26-32
24103422-5	2013	Concomitant inhibition of Bcl-xL and Mcl-1 using ABT 737 or siXL1 associated with citrate was far more effective in inhibiting cell proliferation and inducing cell death than treatment alone.Given that few, if any, specific inhibitors of Mcl-1 are currently available, anti-glycolytic agents such as citrate could be tested in association with synthetic inhibitors of Bcl-xL.	Citric Acid	82-89	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	37-42
24103422-5	2013	Concomitant inhibition of Bcl-xL and Mcl-1 using ABT 737 or siXL1 associated with citrate was far more effective in inhibiting cell proliferation and inducing cell death than treatment alone.Given that few, if any, specific inhibitors of Mcl-1 are currently available, anti-glycolytic agents such as citrate could be tested in association with synthetic inhibitors of Bcl-xL.	Citric Acid	82-89	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	238-243
24103422-5	2013	Concomitant inhibition of Bcl-xL and Mcl-1 using ABT 737 or siXL1 associated with citrate was far more effective in inhibiting cell proliferation and inducing cell death than treatment alone.Given that few, if any, specific inhibitors of Mcl-1 are currently available, anti-glycolytic agents such as citrate could be tested in association with synthetic inhibitors of Bcl-xL.	Citric Acid	82-89	BCL2 like 1	Homo sapiens	368-374
24103422-5	2013	Concomitant inhibition of Bcl-xL and Mcl-1 using ABT 737 or siXL1 associated with citrate was far more effective in inhibiting cell proliferation and inducing cell death than treatment alone.Given that few, if any, specific inhibitors of Mcl-1 are currently available, anti-glycolytic agents such as citrate could be tested in association with synthetic inhibitors of Bcl-xL.	Citric Acid	300-307	BCL2 like 1	Homo sapiens	26-32
24103422-5	2013	Concomitant inhibition of Bcl-xL and Mcl-1 using ABT 737 or siXL1 associated with citrate was far more effective in inhibiting cell proliferation and inducing cell death than treatment alone.Given that few, if any, specific inhibitors of Mcl-1 are currently available, anti-glycolytic agents such as citrate could be tested in association with synthetic inhibitors of Bcl-xL.	Citric Acid	300-307	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	37-42
24409720-5	2013	And compared with the samples using citric acid or sucrose as carbon source, the sample which was synthetized with mixed carbon source (mixed by citric acid and sucrose) exhibited higher I(D)/I(G) ratios and sp2/sp3 peak area ratios.	Citric Acid	145-156	Sp2 transcription factor	Homo sapiens	208-211
23958001-7	2013	A significant increase for citrate was observed in evening milk.	Citric Acid	27-34	Weaning weight-maternal milk	Bos taurus	59-63
24103587-10	2013	Using the same calcium concentration (1.5 mM), citrate dialysis fluid resulted in lower post-dialysis plasma ionized calcium level (1.10 mM vs. 1.27 mM for control, p &lt; 0.0001) and higher post-dialysis PTH level (28.8 pM vs. 14.7 pM for control, p &lt; 0.0001) while pre-dialysis levels were unaffected.	Citric Acid	47-54	parathyroid hormone	Homo sapiens	205-208
24103587-11	2013	Citrate reduced intra-dialytic induction of PTX-3 (+1.1 ng/ml vs. +1.4 ng/ml for control, p = 0.04) but had no effect on other markers of inflammation or oxidative stress.	Citric Acid	0-7	pentraxin 3	Homo sapiens	44-49
24123010-7	2013	Citric acid increased the level of Bcl-2-associated X protein (BAX) and reduced the levels of B-cell lymphoma-2 (BCL-2), B-cell lymphoma-extra large (BCL-XL) and activated caspase-9 and caspase-3, which subsequently induced apoptosis via caspase-dependent and caspase-independent pathways.	Citric Acid	0-11	BCL2 associated X, apoptosis regulator	Homo sapiens	63-66
24123010-7	2013	Citric acid increased the level of Bcl-2-associated X protein (BAX) and reduced the levels of B-cell lymphoma-2 (BCL-2), B-cell lymphoma-extra large (BCL-XL) and activated caspase-9 and caspase-3, which subsequently induced apoptosis via caspase-dependent and caspase-independent pathways.	Citric Acid	0-11	BCL2 apoptosis regulator	Homo sapiens	94-111
24123010-7	2013	Citric acid increased the level of Bcl-2-associated X protein (BAX) and reduced the levels of B-cell lymphoma-2 (BCL-2), B-cell lymphoma-extra large (BCL-XL) and activated caspase-9 and caspase-3, which subsequently induced apoptosis via caspase-dependent and caspase-independent pathways.	Citric Acid	0-11	BCL2 apoptosis regulator	Homo sapiens	113-118
24123010-7	2013	Citric acid increased the level of Bcl-2-associated X protein (BAX) and reduced the levels of B-cell lymphoma-2 (BCL-2), B-cell lymphoma-extra large (BCL-XL) and activated caspase-9 and caspase-3, which subsequently induced apoptosis via caspase-dependent and caspase-independent pathways.	Citric Acid	0-11	BCL2 like 1	Homo sapiens	121-148
24123010-7	2013	Citric acid increased the level of Bcl-2-associated X protein (BAX) and reduced the levels of B-cell lymphoma-2 (BCL-2), B-cell lymphoma-extra large (BCL-XL) and activated caspase-9 and caspase-3, which subsequently induced apoptosis via caspase-dependent and caspase-independent pathways.	Citric Acid	0-11	BCL2 like 1	Homo sapiens	150-156
24123010-7	2013	Citric acid increased the level of Bcl-2-associated X protein (BAX) and reduced the levels of B-cell lymphoma-2 (BCL-2), B-cell lymphoma-extra large (BCL-XL) and activated caspase-9 and caspase-3, which subsequently induced apoptosis via caspase-dependent and caspase-independent pathways.	Citric Acid	0-11	caspase 9	Homo sapiens	172-181
24123010-7	2013	Citric acid increased the level of Bcl-2-associated X protein (BAX) and reduced the levels of B-cell lymphoma-2 (BCL-2), B-cell lymphoma-extra large (BCL-XL) and activated caspase-9 and caspase-3, which subsequently induced apoptosis via caspase-dependent and caspase-independent pathways.	Citric Acid	0-11	caspase 3	Homo sapiens	186-195
24123010-8	2013	Citric acid also activated death receptors and increased the levels of caspase-8, activated BH3 interacting-domain death agonist (BID) protein, Apoptosis-inducing factor (AIF), and Endonuclease G (EndoG).	Citric Acid	0-11	caspase 8	Homo sapiens	71-80
24123010-8	2013	Citric acid also activated death receptors and increased the levels of caspase-8, activated BH3 interacting-domain death agonist (BID) protein, Apoptosis-inducing factor (AIF), and Endonuclease G (EndoG).	Citric Acid	0-11	BH3 interacting domain death agonist	Homo sapiens	130-133
24123010-8	2013	Citric acid also activated death receptors and increased the levels of caspase-8, activated BH3 interacting-domain death agonist (BID) protein, Apoptosis-inducing factor (AIF), and Endonuclease G (EndoG).	Citric Acid	0-11	apoptosis inducing factor mitochondria associated 1	Homo sapiens	144-169
24123010-8	2013	Citric acid also activated death receptors and increased the levels of caspase-8, activated BH3 interacting-domain death agonist (BID) protein, Apoptosis-inducing factor (AIF), and Endonuclease G (EndoG).	Citric Acid	0-11	apoptosis inducing factor mitochondria associated 1	Homo sapiens	171-174
24123010-8	2013	Citric acid also activated death receptors and increased the levels of caspase-8, activated BH3 interacting-domain death agonist (BID) protein, Apoptosis-inducing factor (AIF), and Endonuclease G (EndoG).	Citric Acid	0-11	endonuclease G	Homo sapiens	181-195
24123010-8	2013	Citric acid also activated death receptors and increased the levels of caspase-8, activated BH3 interacting-domain death agonist (BID) protein, Apoptosis-inducing factor (AIF), and Endonuclease G (EndoG).	Citric Acid	0-11	endonuclease G	Homo sapiens	197-202
23833257-0	2013	SLC26A6 and NaDC-1 transporters interact to regulate oxalate and citrate homeostasis.	Citric Acid	65-72	solute carrier family 26, member 6	Mus musculus	0-7
23833257-0	2013	SLC26A6 and NaDC-1 transporters interact to regulate oxalate and citrate homeostasis.	Citric Acid	65-72	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2	Mus musculus	12-18
23833257-2	2013	Here, we examined the relationship between the oxalate transporter SLC26A6 and the citrate transporter NaDC-1 in citrate and oxalate homeostasis.	Citric Acid	83-90	solute carrier family 26, member 6	Mus musculus	67-74
23833257-2	2013	Here, we examined the relationship between the oxalate transporter SLC26A6 and the citrate transporter NaDC-1 in citrate and oxalate homeostasis.	Citric Acid	83-90	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2	Mus musculus	103-109
23833257-5	2013	In contrast, Slc26a6 inhibited NaDC-1 transport activity in an activity dependent manner to restricted tubular citrate absorption.	Citric Acid	111-118	solute carrier family 26, member 6	Mus musculus	13-20
23833257-5	2013	In contrast, Slc26a6 inhibited NaDC-1 transport activity in an activity dependent manner to restricted tubular citrate absorption.	Citric Acid	111-118	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2	Mus musculus	31-37
23858010-4	2013	Laryngeal citric acid-evoked swallowing was mimicked by laryngeal capsaicin challenges, implicating transient receptor potential vanilloid 1 (TRPV1)-expressing laryngeal afferent nerves arising from the jugular ganglia.	Citric Acid	10-21	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	100-140
23900858-8	2013	As expected, c-Fos-immunopositive cells were also found in these regions, suggesting that increased FDG signals induced by intraoral citrate injection are likely to reflect neural activity in these regions.	Citric Acid	133-140	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	13-18
23918900-7	2013	Furthermore, using a combination of pharmacological and mutagenesis approaches, we identified citrate as an "open channel blocker" of AtALMT9 and used this tool to examine the inhibition sensitivity of different point mutants of highly conserved amino acid residues.	Citric Acid	94-101	aluminum-activated malate transporter 9	Arabidopsis thaliana	134-141
23918900-9	2013	Moreover, using a citrate-insensitive AtALMT9 mutant and biochemical approaches, we could demonstrate that AtALMT9 forms a multimeric complex that is supposedly composed of four subunits.	Citric Acid	18-25	aluminum-activated malate transporter 9	Arabidopsis thaliana	107-114
23858010-4	2013	Laryngeal citric acid-evoked swallowing was mimicked by laryngeal capsaicin challenges, implicating transient receptor potential vanilloid 1 (TRPV1)-expressing laryngeal afferent nerves arising from the jugular ganglia.	Citric Acid	10-21	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	142-147
24280423-13	2013	Analysis of more than 500 metabolites upon LDHA inhibition in Snu398 cells revealed that intracellular concentrations of glycolysis and citric acid cycle intermediates were increased, consistent with enhanced Krebs cycle activity and blockage of cytosolic glycolysis.	Citric Acid	136-147	lactate dehydrogenase A	Homo sapiens	43-47
24010567-2	2013	These effects were likely mediated by the induction of key regulators of fiber transition, PGC-1alpha and PGC-1beta, leading to muscle fiber switching and up-regulation of genes involved in mitochondrial fatty acid import and oxidation, citrate cycle, oxidative phosphorylation, mitochondrial biogenesis.	Citric Acid	237-244	PPARG coactivator 1 alpha	Sus scrofa	91-101
24046774-3	2013	Roots of soil-grown plants accumulate iron in the apoplast of the central cylinder, a pattern that is strongly intensified when the citrate effluxer FRD3 is not functional, thus stressing the importance of citrate in the apoplastic movement of Fe.	Citric Acid	132-139	MATE efflux family protein	Arabidopsis thaliana	149-153
23763865-3	2013	Electrostatic repulsion between citrate-coated AuNPs and rat CYP2B1 may influence the active conformation of the isozyme and consequently affect its activity and stereoselectivity.	Citric Acid	32-39	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	61-67
23161184-4	2013	Increased vascularization in chorioallantoic membrane assay, increased endothelial sprouting in rat aortic rings, and increased expression of CD31, E-selectin in endothelial cells suggested a possible proangiogenic effect of citrate.	Citric Acid	225-232	platelet and endothelial cell adhesion molecule 1	Rattus norvegicus	142-146
23161184-4	2013	Increased vascularization in chorioallantoic membrane assay, increased endothelial sprouting in rat aortic rings, and increased expression of CD31, E-selectin in endothelial cells suggested a possible proangiogenic effect of citrate.	Citric Acid	225-232	selectin E	Rattus norvegicus	148-158
23161184-5	2013	Upregulation of angiogenic factors such as vascular endothelial growth factor and fibroblast growth factor suggested that the effect of citrate involves modulation of expression of angiogenic growth factors.	Citric Acid	136-143	vascular endothelial growth factor A	Homo sapiens	43-77
23161184-6	2013	LY 294002, an inhibitor of PI3K-Akt pathway, and wortmannin, an inhibitor of Akt pathway, reversed the effect of citrate in human umbilical vein endothelial cells.	Citric Acid	113-120	AKT serine/threonine kinase 1	Homo sapiens	77-80
23161184-7	2013	Citrate induced significant upregulation and activation of Akt in endothelial cells.	Citric Acid	0-7	AKT serine/threonine kinase 1	Homo sapiens	59-62
23161184-8	2013	Rapamycin, an inhibitor of mTOR, also reversed the effect of citrate in human umbilical vein endothelial cells and sprouting of aortic rings suggesting that the angiogenic effect of citrate involves activation of PI3K-Akt-mTOR pathway.	Citric Acid	61-68	mechanistic target of rapamycin kinase	Homo sapiens	27-31
23161184-8	2013	Rapamycin, an inhibitor of mTOR, also reversed the effect of citrate in human umbilical vein endothelial cells and sprouting of aortic rings suggesting that the angiogenic effect of citrate involves activation of PI3K-Akt-mTOR pathway.	Citric Acid	61-68	AKT serine/threonine kinase 1	Homo sapiens	218-221
23161184-8	2013	Rapamycin, an inhibitor of mTOR, also reversed the effect of citrate in human umbilical vein endothelial cells and sprouting of aortic rings suggesting that the angiogenic effect of citrate involves activation of PI3K-Akt-mTOR pathway.	Citric Acid	61-68	mechanistic target of rapamycin kinase	Homo sapiens	222-226
23161184-8	2013	Rapamycin, an inhibitor of mTOR, also reversed the effect of citrate in human umbilical vein endothelial cells and sprouting of aortic rings suggesting that the angiogenic effect of citrate involves activation of PI3K-Akt-mTOR pathway.	Citric Acid	182-189	mechanistic target of rapamycin kinase	Homo sapiens	27-31
23161184-8	2013	Rapamycin, an inhibitor of mTOR, also reversed the effect of citrate in human umbilical vein endothelial cells and sprouting of aortic rings suggesting that the angiogenic effect of citrate involves activation of PI3K-Akt-mTOR pathway.	Citric Acid	182-189	AKT serine/threonine kinase 1	Homo sapiens	218-221
23161184-8	2013	Rapamycin, an inhibitor of mTOR, also reversed the effect of citrate in human umbilical vein endothelial cells and sprouting of aortic rings suggesting that the angiogenic effect of citrate involves activation of PI3K-Akt-mTOR pathway.	Citric Acid	182-189	mechanistic target of rapamycin kinase	Homo sapiens	222-226
23819811-1	2013	A one-dimensional mathematical model is developed and implemented to describe the coupled transport of citrate-stabilized silver nanoparticles (nAg) and dissolved silver ions in porous media.	Citric Acid	103-110	NBAS subunit of NRZ tethering complex	Homo sapiens	144-147
23819811-4	2013	A three pore volume pulse of a citrate-stabilized nAg suspension (ca.	Citric Acid	31-38	NBAS subunit of NRZ tethering complex	Homo sapiens	50-53
23798600-0	2013	The barley MATE gene, HvAACT1, increases citrate efflux and Al(3+) tolerance when expressed in wheat and barley.	Citric Acid	41-48	HvMATE	Hordeum vulgare	11-15
23798600-3	2013	The Al(3+)-activated release of citrate from the root apices of Al(3+)-tolerant genotypes of barley is controlled by a MATE gene named HvAACT1 that encodes a citrate transport protein located on the plasma membrane.	Citric Acid	32-39	HvMATE	Hordeum vulgare	119-123
23798600-3	2013	The Al(3+)-activated release of citrate from the root apices of Al(3+)-tolerant genotypes of barley is controlled by a MATE gene named HvAACT1 that encodes a citrate transport protein located on the plasma membrane.	Citric Acid	158-165	HvMATE	Hordeum vulgare	119-123
23773695-6	2013	RESULTS: Serum and plasma anticoagulated with citrate or heparin had equivalent ADAMTS13 activity with FRETS-rVWF71.	Citric Acid	46-53	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	80-88
23747014-4	2013	Here, we report that glutamine-dependent oxidative citric acid cycle metabolism is required to generate fumarate and increase ROS and HIF-1 levels.	Citric Acid	51-62	hypoxia inducible factor 1 subunit alpha	Homo sapiens	134-139
23370576-0	2013	Mechanisms of divergent effects of activated peroxisome proliferator-activated receptor-gamma on mitochondrial citrate carrier expression in 3T3-L1 fibroblasts and mature adipocytes.	Citric Acid	111-118	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	45-93
23449767-1	2013	BACKGROUND AND OBJECTIVES: Lower urinary citrate excretion is a risk factor for nephrolithiasis and associated with metabolic acidosis and higher prevalence of hypertension and insulin resistance.	Citric Acid	41-48	insulin	Homo sapiens	177-184
23550275-2	2013	Aconitase (ACO2) is an essential enzyme located in the mitochondria and catalyzes the interconversion of citrate and isocitrate in the tricarboxylic acid cycle.	Citric Acid	105-112	aconitase 2	Homo sapiens	11-15
24955952-0	2013	Citrate-linked keto- and aldo-hexose monosaccharide cellulose conjugates demonstrate selective human neutrophil elastase-lowering activity in cotton dressings.	Citric Acid	0-7	elastase, neutrophil expressed	Homo sapiens	101-120
23504317-2	2013	In addition, reductive carboxylation of alpha-ketoglutarate by isocitrate dehydrogenase 1 (IDH1) and 2 (IDH2) was recently shown to be a major source of citrate synthesis from glutamine.	Citric Acid	66-73	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	91-95
23504317-2	2013	In addition, reductive carboxylation of alpha-ketoglutarate by isocitrate dehydrogenase 1 (IDH1) and 2 (IDH2) was recently shown to be a major source of citrate synthesis from glutamine.	Citric Acid	66-73	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	104-108
23926603-4	2013	report on the function of an exciting new paracrine mediator, the mitochondrial the citric acid(TCA) cycle intermediate alpha-ketoglutarate (alphaKG), which via its OXGR1 receptor plays an unexpected, nontraditional role in the adaptive regulation of renal HCO(3-) secretion and salt reabsorption.	Citric Acid	84-95	oxoglutarate receptor 1	Homo sapiens	165-170
23709747-3	2013	Mitochondrial aconitase (mACON) (ACONM) is an enzyme that is central to carbohydrate and energy metabolism and is responsible for the interconversion of citrate to isocitrate as part of the citric acid cycle in the human prostate.	Citric Acid	153-160	aconitase 2	Homo sapiens	0-23
23709747-3	2013	Mitochondrial aconitase (mACON) (ACONM) is an enzyme that is central to carbohydrate and energy metabolism and is responsible for the interconversion of citrate to isocitrate as part of the citric acid cycle in the human prostate.	Citric Acid	153-160	aconitase 2	Homo sapiens	33-38
23709747-3	2013	Mitochondrial aconitase (mACON) (ACONM) is an enzyme that is central to carbohydrate and energy metabolism and is responsible for the interconversion of citrate to isocitrate as part of the citric acid cycle in the human prostate.	Citric Acid	190-201	aconitase 2	Homo sapiens	0-23
23709747-3	2013	Mitochondrial aconitase (mACON) (ACONM) is an enzyme that is central to carbohydrate and energy metabolism and is responsible for the interconversion of citrate to isocitrate as part of the citric acid cycle in the human prostate.	Citric Acid	190-201	aconitase 2	Homo sapiens	33-38
23321217-3	2013	RESEARCH DESIGN AND METHODS: We determined VEGF levels in plasma collected in both citrate and PECT, a medium that inactivates platelets, in a cross-sectional cohort of 21 healthy subjects and 64 patients with type 1 diabetes.	Citric Acid	83-90	vascular endothelial growth factor A	Homo sapiens	43-47
23321217-6	2013	In contrast, VEGF levels in citrate plasma were 150% higher in diabetic patients than in control subjects and correlated with diabetes-related variables.	Citric Acid	28-35	vascular endothelial growth factor A	Homo sapiens	13-17
23321217-7	2013	Multiple linear regression analysis showed that levels of platelet factor 4, a marker for ex vivo platelet activation, and HbA1c were the independent predictors of VEGF levels in citrate plasma.	Citric Acid	179-186	vascular endothelial growth factor A	Homo sapiens	164-168
23321217-11	2013	Higher levels of VEGF in citrate plasma samples of diabetic persons do not represent the in vivo situation, but mainly originate from higher artificial ex vivo release from platelets correlating with the degree of glycemic control.	Citric Acid	25-32	vascular endothelial growth factor A	Homo sapiens	17-21
32261042-0	2013	Structure and dynamics of the hydration shells of citrate-coated GdF3 nanoparticles.	Citric Acid	50-57	growth differentiation factor 3	Homo sapiens	65-69
32261042-1	2013	The 1H and 17O relaxometric behaviour in aqueous solution of GdF3 nanoparticles (<5 nm) coated with citrate molecules (Gd-NPs) was investigated as a function of magnetic field strength and temperature in order to unravel the mechanisms underlying their magnetic interaction with water molecules.	Citric Acid	100-107	growth differentiation factor 3	Homo sapiens	61-65
23564607-8	2013	A robust diminution in the activity of succinate dehydrogenase and moderate decline in the citrate synthase activity suggested a specific effect on citric acid cycle enzymes.	Citric Acid	148-159	knockdown	Drosophila melanogaster	91-107
23456655-7	2013	The CSF levels of the citric, isocitric, and lactic acids were significantly higher in grade I-III gliomas with mutant IDH than in those with wild-type IDH.	Citric Acid	22-28	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	119-122
23616560-9	2013	Both sour citric acid and salty NaCl increased NPY secretion but had no effects on GLP-1 or glucagon.	Citric Acid	10-21	neuropeptide Y	Mus musculus	47-50
23580130-2	2013	The fly Indy gene and its mammalian homolog are transporters of Krebs cycle intermediates, with the highest rate of uptake for citrate.	Citric Acid	127-134	I'm not dead yet	Drosophila melanogaster	8-12
23561848-0	2013	Deficiency in SLC25A1, encoding the mitochondrial citrate carrier, causes combined D-2- and L-2-hydroxyglutaric aciduria.	Citric Acid	50-57	solute carrier family 25 member 1	Homo sapiens	14-21
23561848-4	2013	Complementary to these findings, we now report recessive mutations in SLC25A1, the mitochondrial citrate carrier, in 12 out of 12 individuals with combined D-2- and L-2-hydroxyglutaric aciduria.	Citric Acid	97-104	solute carrier family 25 member 1	Homo sapiens	70-77
23299802-5	2013	The protective function exerted by PGC-1beta is due to its ability to induce mitochondrial oxidative phosphorylation, fatty acid beta-oxidation, and citrate cycle, as well as to decrease oxidative stress and promote TG secretion in the blood stream.	Citric Acid	149-156	peroxisome proliferative activated receptor, gamma, coactivator 1 beta	Mus musculus	35-44
23403202-10	2013	The largest citrate associated effect was in the 3" untranslated region of the SLC25A1 gene, which is responsible for the transport of citrate across the mitochondrial inner membrane.	Citric Acid	12-19	solute carrier family 25 member 1	Bos taurus	79-86
23403202-10	2013	The largest citrate associated effect was in the 3" untranslated region of the SLC25A1 gene, which is responsible for the transport of citrate across the mitochondrial inner membrane.	Citric Acid	135-142	solute carrier family 25 member 1	Bos taurus	79-86
23506872-3	2013	While the two SLC13 cotransporters NaS1 (SLC13A1) and NaS2 (SLC13A4) transport anions such sulfate, selenate and thiosulfate, the three other SLC13 members, NaDC1 (SLC13A2), NaCT (SLC13A5) and NaDC3 (SLC13A3), transport di- and tri-carboxylate Krebs cycle intermediates such as succinate, citrate and alpha-ketoglutarate.	Citric Acid	289-296	solute carrier family 13 member 1	Homo sapiens	35-39
23506872-3	2013	While the two SLC13 cotransporters NaS1 (SLC13A1) and NaS2 (SLC13A4) transport anions such sulfate, selenate and thiosulfate, the three other SLC13 members, NaDC1 (SLC13A2), NaCT (SLC13A5) and NaDC3 (SLC13A3), transport di- and tri-carboxylate Krebs cycle intermediates such as succinate, citrate and alpha-ketoglutarate.	Citric Acid	289-296	solute carrier family 13 member 1	Homo sapiens	41-48
23506872-3	2013	While the two SLC13 cotransporters NaS1 (SLC13A1) and NaS2 (SLC13A4) transport anions such sulfate, selenate and thiosulfate, the three other SLC13 members, NaDC1 (SLC13A2), NaCT (SLC13A5) and NaDC3 (SLC13A3), transport di- and tri-carboxylate Krebs cycle intermediates such as succinate, citrate and alpha-ketoglutarate.	Citric Acid	289-296	solute carrier family 13 member 4	Homo sapiens	54-58
23506872-3	2013	While the two SLC13 cotransporters NaS1 (SLC13A1) and NaS2 (SLC13A4) transport anions such sulfate, selenate and thiosulfate, the three other SLC13 members, NaDC1 (SLC13A2), NaCT (SLC13A5) and NaDC3 (SLC13A3), transport di- and tri-carboxylate Krebs cycle intermediates such as succinate, citrate and alpha-ketoglutarate.	Citric Acid	289-296	solute carrier family 13 member 4	Homo sapiens	60-67
23242143-8	2013	Moreover, LC3 stains were optimal in neutral-buffered formalin-fixed tissue, immersed in citrate buffer during antigen retrieval.	Citric Acid	89-96	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	10-13
23473032-4	2013	Feeding VHL-deficient RCC cells with acetate or citrate or knocking down PDK-1 and ACLY restored citrate levels and suppressed RC.	Citric Acid	97-104	pyruvate dehydrogenase kinase, isoenzyme 1	Mus musculus	73-78
23473032-4	2013	Feeding VHL-deficient RCC cells with acetate or citrate or knocking down PDK-1 and ACLY restored citrate levels and suppressed RC.	Citric Acid	97-104	ATP citrate lyase	Mus musculus	83-87
23314954-3	2013	In this study, we compared in vitro uptake and binding of electrostatically stabilized citrate-coated very small superparamagnetic iron oxide particles (VSOP) to THP-1 cells with sterically stabilized carboxydextran-coated Resovist( ).	Citric Acid	87-94	GLI family zinc finger 2	Homo sapiens	162-167
23223024-6	2013	In contrast, genes related to beta-oxidation and the citric acid cycle were relatively overexpressed in adipose of insulin-sensitive patients.	Citric Acid	53-64	insulin	Homo sapiens	115-122
23015148-7	2013	Serum metabolomics revealed higher glycerol and citrate levels in the VHL ( R200W ) homozygotes.	Citric Acid	48-55	von Hippel-Lindau tumor suppressor	Homo sapiens	70-73
23399274-1	2013	Novel poly(vinyl alcohol)/citric acid/chitosan (PVA/CA/CHT, PCC) beads were prepared as an adsorbent for the removal of trivalent chromium (Cr(3+)) in aqueous solutions.	Citric Acid	26-37	crystallin gamma D	Homo sapiens	60-63
23369146-8	2013	The fentanyl-induced enhancement of the number of citric acid-induced coughs was abolished in mice that had been pretreated with moguisteine, a rapidly adapting receptor (RAR) antagonist or fexofenadine, a histamine H1 receptor antagonist.	Citric Acid	50-61	histamine receptor H1	Mus musculus	206-227
23258564-5	2013	Additionally, HFI could easily precipitate and had progressive characteristics and thus, the buffer system of the additive phosphate-citric acid buffer, arginine, Triton X-100 or Tween-80, the establishment of a microfiltration, ion exchange, affinity chromatography and gel filtration chromatography-based purification process were explored.	Citric Acid	133-144	major intrinsic protein of lens fiber	Mus musculus	14-17
22562483-0	2013	Both decrease in ACL1 gene expression and increase in ICL1 gene expression in marine-derived yeast Yarrowia lipolytica expressing INU1 gene enhance citric acid production from inulin.	Citric Acid	148-159	isocitrate lyase 1	Saccharomyces cerevisiae S288C	54-58
23204428-0	2013	Transposon-mediated alteration of TaMATE1B expression in wheat confers constitutive citrate efflux from root apices.	Citric Acid	84-91	LOC101664696	Triticum aestivum	34-42
23204428-3	2013	The coding region of TaMATE1B was identical in a genotype showing citrate efflux from root apices (cv Carazinho) to one that lacked citrate efflux (cv Egret).	Citric Acid	66-73	LOC101664696	Triticum aestivum	21-29
23204428-3	2013	The coding region of TaMATE1B was identical in a genotype showing citrate efflux from root apices (cv Carazinho) to one that lacked citrate efflux (cv Egret).	Citric Acid	132-139	LOC101664696	Triticum aestivum	21-29
23204428-11	2013	We conclude that the transposon-like element in cv Carazinho extends TaMATE1B expression to the root apex, where it confers citrate efflux and enhanced aluminum tolerance.	Citric Acid	124-131	LOC101664696	Triticum aestivum	69-77
23327614-0	2013	Acetate free citrate-containing dialysate increase intact-PTH and BAP levels in the patients with low intact-PTH.	Citric Acid	13-20	parathyroid hormone	Homo sapiens	58-61
23327614-0	2013	Acetate free citrate-containing dialysate increase intact-PTH and BAP levels in the patients with low intact-PTH.	Citric Acid	13-20	parathyroid hormone	Homo sapiens	109-112
23737849-3	2013	In in vivo rat model of myocardial ischemia/reperfusion injury, we found that treatments with citric acid and L-malic acid significantly reduced myocardial infarct size, serum levels of TNF-alpha, and platelet aggregation.	Citric Acid	94-105	tumor necrosis factor	Rattus norvegicus	186-195
23737849-4	2013	In vitro experiments revealed that both citric acid and L-malic acid significantly reduced LDH release, decreased apoptotic rate, downregulated the expression of cleaved caspase-3, and upregulated the expression of phosphorylated Akt in primary neonatal rat cardiomyocytes subjected to hypoxia/reoxygenation injury.	Citric Acid	40-51	AKT serine/threonine kinase 1	Rattus norvegicus	230-233
23019249-1	2013	This study was conducted to develop a method for the simultaneous separation and detection of antimonite (Sb(III)), antimonate (Sb(V)) and trimethyl antinmony (TMSb) species in soils, using ultrasonic-aided citric acid extraction and high-performance liquid chromatography-inductively coupled plasma-mass spectrometry separation and detection.	Citric Acid	207-218	tropomyosin 2	Homo sapiens	160-164
23353549-4	2013	By gene disruption strategy, idh1 and idh2 genes involved in citrate turnover in tricarboxylic acid cycle (TCA cycle) were disrupted and the citrate production level was increased to 4- and 5-times in mutant yeast strains.	Citric Acid	61-68	isocitrate dehydrogenase (NAD(+)) IDH1	Saccharomyces cerevisiae S288C	29-33
23353549-4	2013	By gene disruption strategy, idh1 and idh2 genes involved in citrate turnover in tricarboxylic acid cycle (TCA cycle) were disrupted and the citrate production level was increased to 4- and 5-times in mutant yeast strains.	Citric Acid	61-68	isocitrate dehydrogenase (NAD(+)) IDH2	Saccharomyces cerevisiae S288C	38-42
23353549-4	2013	By gene disruption strategy, idh1 and idh2 genes involved in citrate turnover in tricarboxylic acid cycle (TCA cycle) were disrupted and the citrate production level was increased to 4- and 5-times in mutant yeast strains.	Citric Acid	141-148	isocitrate dehydrogenase (NAD(+)) IDH1	Saccharomyces cerevisiae S288C	29-33
23353549-4	2013	By gene disruption strategy, idh1 and idh2 genes involved in citrate turnover in tricarboxylic acid cycle (TCA cycle) were disrupted and the citrate production level was increased to 4- and 5-times in mutant yeast strains.	Citric Acid	141-148	isocitrate dehydrogenase (NAD(+)) IDH2	Saccharomyces cerevisiae S288C	38-42
23306859-11	2013	We therefore conclude that VN P2Y12 with hirudin anticoagulation can be performed more rapidly and results are strongly correlated with delayed citrate measurements.	Citric Acid	144-151	purinergic receptor P2Y12	Homo sapiens	30-35
23112137-3	2013	Here we show for the first time that citrate-stabilized gold nanoparticles, in a size dependent manner, specifically downregulate cellular responses induced by IL-1beta both in vitro and in vivo.	Citric Acid	37-44	interleukin 1 beta	Homo sapiens	160-168
22828478-0	2013	C-Myc induced compensated cardiac hypertrophy increases free fatty acid utilization for the citric acid cycle.	Citric Acid	92-103	myelocytomatosis oncogene	Mus musculus	0-5
24832661-4	2013	This review focuses on the transcriptional control of two genes involved in fatty acid biosynthesis and oxidation: the citrate carrier (CIC) and the carnitine/ acylcarnitine/carrier (CAC), which are members of the mitochondrial carrier gene family, SLC25.	Citric Acid	119-126	solute carrier family 25 member 20	Homo sapiens	149-187
23163577-8	2013	Citrate increased UO(2) reoxidation with ferrihydrite at a rate of 1.8 muM day(-1), but did not increase the extent of reaction with goethite or hematite, with no reoxidation in this case.	Citric Acid	0-7	latexin	Homo sapiens	71-74
24251349-4	2013	We find that low concentrations of citrate (10-100 muM) induced a reduction in step retreat rates along both the [100]Cc and [101]Cc directions.	Citric Acid	35-42	latexin	Homo sapiens	51-54
24219503-6	2013	In this work, we investigated the influence of citrate-capped gold nanoparticles on the aggregation kinetics of AS using a fluorescent probe (MFC) sensitive to the polarity of the molecular microenvironment via excited state intramolecular proton transfer (ESIPT).	Citric Acid	47-54	long intergenic non-protein coding RNA 2605	Homo sapiens	112-114
24066190-1	2013	Aconitase, the second enzyme of the tricarboxylic acid cycle encoded by ACO1 in the budding yeast Saccharomyces cerevisiae, catalyzes the conversion of citrate to isocitrate.	Citric Acid	152-159	aconitate hydratase ACO1	Saccharomyces cerevisiae S288C	72-76
23283237-9	2012	Citrate-stimulated NADPH responses were also significantly larger in FGF21-treated islets suggesting preference for citrate cycling rather than acetyl-CoA carboxylase-dependent fatty acid synthesis.	Citric Acid	0-7	fibroblast growth factor 21	Homo sapiens	69-74
23283237-9	2012	Citrate-stimulated NADPH responses were also significantly larger in FGF21-treated islets suggesting preference for citrate cycling rather than acetyl-CoA carboxylase-dependent fatty acid synthesis.	Citric Acid	116-123	fibroblast growth factor 21	Homo sapiens	69-74
23052210-0	2012	Citrate kills tumor cells through activation of apical caspases.	Citric Acid	0-7	caspase 2	Homo sapiens	55-63
23018274-0	2012	Interaction of [Ru(eta6-p-cym)(H2O)3]2+ with citrate and tricarballate ions in aqueous solution; X-ray crystal structure of novel half-sandwich Ru(II)-citrato complexes.	Citric Acid	45-52	endothelin receptor type A	Homo sapiens	19-22
23018274-6	2012	Crucial role of the alcoholic/alcoholate function of the citric acid in [Ru(eta(6)-p-cym)(H(2)O)(3)](2+) binding is reflected in the low stability of the species formed with tricarballylic acid.	Citric Acid	57-68	endothelin receptor type A	Homo sapiens	76-79
23052210-6	2012	Hence, increasing concentrations of citrate induced characteristic manifestations of apoptosis, such as caspase-3 activation, and poly-ADP-ribose polymerase cleavage, as well as the release of cytochrome c.	Citric Acid	36-43	poly(ADP-ribose) polymerase 1	Homo sapiens	130-156
23052210-6	2012	Hence, increasing concentrations of citrate induced characteristic manifestations of apoptosis, such as caspase-3 activation, and poly-ADP-ribose polymerase cleavage, as well as the release of cytochrome c.	Citric Acid	36-43	cytochrome c, somatic	Homo sapiens	193-205
23052210-8	2012	We propose that the activation of apical caspases by citrate could be explained by its kosmotropic properties.	Citric Acid	53-60	caspase 2	Homo sapiens	41-49
23052210-9	2012	Caspase-8 is activated by proximity-induced dimerization, which might be facilitated by citrate through the stabilization of intermolecular interactions between the proteins.	Citric Acid	88-95	caspase 8	Homo sapiens	0-9
23106124-7	2012	While yeast Aco1p is essential for the citric acid cycle and, thus, for glutamate synthesis, Aco2p specifically and exclusively contributes to lysine biosynthesis.	Citric Acid	39-50	aconitate hydratase ACO1	Saccharomyces cerevisiae S288C	12-17
22683389-4	2012	Our results indicate that deletion of the lon gene in the DeltarfaJ strain did not affect invasiveness in IPEC-J2 cells and resulted in an increased susceptibility to UV, disinfectants (such as hydrogen peroxide and tosylchloramide sodium) and citric acid.	Citric Acid	244-255	lon peptidase 1, mitochondrial	Mus musculus	42-45
23226729-1	2012	IDH2 encodes a mitochondrial metabolic enzyme that converts isocitrate to alpha-ketoglutarate (alpha-KG) by reducing nicotinamide adenine dinucleotide phosphate (NADP(+)) to NADPH and participates in the citric acid cycle for energy production.	Citric Acid	204-215	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	0-4
22802136-0	2012	D-Amino acid oxidase-induced oxidative stress, 3-bromopyruvate and citrate inhibit angiogenesis, exhibiting potent anticancer effects.	Citric Acid	67-74	D-amino acid oxidase	Homo sapiens	0-20
23052210-5	2012	The lethal effect of citrate was found to be related to the activation of apical caspases-8 and -2, rather than to the inhibition of cellular energy metabolism.	Citric Acid	21-28	caspase 8	Homo sapiens	81-98
23052210-6	2012	Hence, increasing concentrations of citrate induced characteristic manifestations of apoptosis, such as caspase-3 activation, and poly-ADP-ribose polymerase cleavage, as well as the release of cytochrome c.	Citric Acid	36-43	caspase 3	Homo sapiens	104-113
22787121-1	2012	ATP-citrate lyase (ACLY) is a cytosolic enzyme that catalyzes the generation of acetyl CoA from citrate.	Citric Acid	4-11	ATP citrate lyase	Homo sapiens	19-23
22962799-1	2012	A novel and practical glucose biosensor was fabricated with immobilization of Glucose oxidase (GOx) enzyme on the surface of citric acid (CA) assisted cobalt ferrite (CF) magnetic nanoparticles (MNPs).	Citric Acid	125-136	hydroxyacid oxidase 1	Homo sapiens	78-93
22516131-10	2012	It was concluded that biofilm-forming ability varies strikingly depending on strain background, and that ClfB is involved in biofilm formation in the presence EGTA and citrate.	Citric Acid	168-175	AT695_RS04065	Staphylococcus aureus	105-109
22962799-1	2012	A novel and practical glucose biosensor was fabricated with immobilization of Glucose oxidase (GOx) enzyme on the surface of citric acid (CA) assisted cobalt ferrite (CF) magnetic nanoparticles (MNPs).	Citric Acid	125-136	hydroxyacid oxidase 1	Homo sapiens	95-98
22920799-2	2012	A novel formulation of recombinant human insulin containing citrate and disodium ethylenediaminetetraacetic acid (EDTA) has been tested in clinic and has a very rapid onset of action in patients with diabetes.	Citric Acid	60-67	insulin	Homo sapiens	41-48
22920799-7	2012	CONCLUSIONS: The combination of rapid dissociation of insulin hexamers upon dilution due to the zinc chelating effects of disodium EDTA followed by the inhibition of insulin monomer/dimer reassociation due to the charge-masking effects of citrate provides the basis for the ultra-rapid absorption of this novel insulin formulation.	Citric Acid	239-246	insulin	Homo sapiens	166-173
22920803-3	2012	In addition, insulin monomer surface charges are chemically masked with citrate to prevent reaggregation.	Citric Acid	72-79	insulin	Homo sapiens	13-20
22506506-5	2012	The covering of Ag nanoparticles with carboxylate groups is necessary to initiate rapid STP transformation by premixing citrate before H(2)O(2) addition.	Citric Acid	120-127	sulfotransferase family 1A member 1	Homo sapiens	88-91
22515552-1	2012	We present in situ observations of adsorption of bovine serum albumin (BSA) on citrate-stabilized gold nanospheres.	Citric Acid	79-86	albumin	Homo sapiens	56-69
22522115-6	2012	RESULTS: The anticoagulation of blood with citrate resulted in decreased levels of PrP(C) on monocytes but not the other cell types.	Citric Acid	43-50	prion protein	Homo sapiens	83-89
22920799-7	2012	CONCLUSIONS: The combination of rapid dissociation of insulin hexamers upon dilution due to the zinc chelating effects of disodium EDTA followed by the inhibition of insulin monomer/dimer reassociation due to the charge-masking effects of citrate provides the basis for the ultra-rapid absorption of this novel insulin formulation.	Citric Acid	239-246	insulin	Homo sapiens	54-61
22920799-7	2012	CONCLUSIONS: The combination of rapid dissociation of insulin hexamers upon dilution due to the zinc chelating effects of disodium EDTA followed by the inhibition of insulin monomer/dimer reassociation due to the charge-masking effects of citrate provides the basis for the ultra-rapid absorption of this novel insulin formulation.	Citric Acid	239-246	insulin	Homo sapiens	166-173
22453629-9	2012	Taken together, these results suggest an intriguing possibility: that increasing brain lactate following hypoglycemia offsets the decrease in NAD(+) due to overactivation of PARP-1 by acting as an alternative energy substrate that can effectively bypass glycolysis and be fed directly to the citric acid cycle to maintain cellular ATP levels.	Citric Acid	292-303	poly(ADP-ribose) polymerase 1	Homo sapiens	174-180
22657152-1	2012	ATP citrate lyase (ACL) catalyzes an ATP-dependent biosynthetic reaction which produces acetyl-coenzyme A and oxaloacetate from citrate and coenzyme A (CoA).	Citric Acid	4-11	ATP citrate lyase	Homo sapiens	19-22
22510345-9	2012	Gene products predicting significantly a reduced citrate level were acetyl citrate lyase (ACLY, P = 0.003) and m-aconitase (ACON, P &lt; 0.001).	Citric Acid	49-56	ATP citrate lyase	Homo sapiens	68-88
22510345-9	2012	Gene products predicting significantly a reduced citrate level were acetyl citrate lyase (ACLY, P = 0.003) and m-aconitase (ACON, P &lt; 0.001).	Citric Acid	49-56	ATP citrate lyase	Homo sapiens	90-94
22794107-6	2012	Similarly, transformants expressing T2R38 and PKD2L1 also showed a similar preference increase for T2R38-specific ligand phenylthiocarbamide (PTC) and a sour-taste ligand, citric acid, respectively.	Citric Acid	172-183	taste 2 receptor member 38	Homo sapiens	36-41
22794107-6	2012	Similarly, transformants expressing T2R38 and PKD2L1 also showed a similar preference increase for T2R38-specific ligand phenylthiocarbamide (PTC) and a sour-taste ligand, citric acid, respectively.	Citric Acid	172-183	polycystin 2 like 1, transient receptor potential cation channel	Homo sapiens	46-52
22575446-1	2012	ATP-citrate lyase (ACLY) is a cytosolic enzyme that catalyzes generation of acetyl-CoA from citrate.	Citric Acid	4-11	ATP citrate lyase	Homo sapiens	19-23
22406166-11	2012	A similar agreement between the total TGF-beta1 and the LAP ELISA was found with citrate- and heparin-containing plasma.	Citric Acid	81-88	transforming growth factor beta 1	Homo sapiens	38-47
22406166-11	2012	A similar agreement between the total TGF-beta1 and the LAP ELISA was found with citrate- and heparin-containing plasma.	Citric Acid	81-88	LAP	Homo sapiens	56-59
22481570-6	2012	Anti-TNF binds to both TNF-conjugated and citrate-stabilized AuNPs, showing that non-specific binding is significant.	Citric Acid	42-49	tumor necrosis factor	Homo sapiens	5-8
22277779-6	2012	However, overexpression of EMI5, LIP5, RTG2 and UBP3 had a significant effect on the production of acetate, citrate, lactate, and succinate in the bottom-fermenting yeast Saccharomyces pastorianus.	Citric Acid	108-115	succinate dehydrogenase assembly factor SDH5	Saccharomyces cerevisiae S288C	27-31
22890268-2	2012	Although AS-3 is based on a saline-adenine-glucose solution, it also contains citrate and phosphate.	Citric Acid	78-85	PDS5 cohesin associated factor B	Homo sapiens	9-13
22277779-6	2012	However, overexpression of EMI5, LIP5, RTG2 and UBP3 had a significant effect on the production of acetate, citrate, lactate, and succinate in the bottom-fermenting yeast Saccharomyces pastorianus.	Citric Acid	108-115	putative lipoate synthase	Saccharomyces cerevisiae S288C	33-37
22277779-6	2012	However, overexpression of EMI5, LIP5, RTG2 and UBP3 had a significant effect on the production of acetate, citrate, lactate, and succinate in the bottom-fermenting yeast Saccharomyces pastorianus.	Citric Acid	108-115	Rtg2p	Saccharomyces cerevisiae S288C	39-43
22277779-6	2012	However, overexpression of EMI5, LIP5, RTG2 and UBP3 had a significant effect on the production of acetate, citrate, lactate, and succinate in the bottom-fermenting yeast Saccharomyces pastorianus.	Citric Acid	108-115	mRNA-binding ubiquitin-specific protease UBP3	Saccharomyces cerevisiae S288C	48-52
21688263-1	2012	ATP citrate lyase (ACL) catalyzes the conversion of cytosolic citrate to acetyl-CoA and oxaloacetate.	Citric Acid	4-11	ATP citrate lyase	Homo sapiens	19-22
22565275-6	2012	After 100 d, the Fe(II) production reached its maximum and 34% of the citrate-bicarbonate-dithionite extractable Fe (Fe(CBD)) was reduced to Fe(II) in the sandy soil.	Citric Acid	70-77	opsin 1, medium wave sensitive	Homo sapiens	117-124
22249025-1	2012	Citrate carrier (CiC), a mitochondrial inner membrane protein, is an essential component of the shuttle system which transports acetyl-CoA from mitochondria to the cytosol where lipogenesis occurs.	Citric Acid	0-7	inner membrane mitochondrial protein	Rattus norvegicus	25-61
22257021-3	2012	Oxytocin degradation products have been identified including citrate adducts formed in a formulation with citrate buffer.	Citric Acid	61-68	oxytocin/neurophysin I prepropeptide	Homo sapiens	0-8
22257021-3	2012	Oxytocin degradation products have been identified including citrate adducts formed in a formulation with citrate buffer.	Citric Acid	106-113	oxytocin/neurophysin I prepropeptide	Homo sapiens	0-8
22257021-4	2012	In a more recent study we have found that divalent metal salts in combination with citrate buffer strongly stabilize oxytocin in aqueous solutions (Avanti, C.; et al.	Citric Acid	83-90	oxytocin/neurophysin I prepropeptide	Homo sapiens	117-125
22257021-6	2012	The aim of the present investigation was to identify various degradation products of oxytocin in citrate-buffered solution after thermal stress at a temperature of 70  C for 5 days and the changes in degradation pattern in the presence of divalent metal ions.	Citric Acid	97-104	oxytocin/neurophysin I prepropeptide	Homo sapiens	85-93
22257021-7	2012	Degradation products of oxytocin in the citrate buffer formulation with and without divalent metal ions were analyzed using liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS).	Citric Acid	40-47	oxytocin/neurophysin I prepropeptide	Homo sapiens	24-32
22257021-11	2012	We therefore postulate that cysteine-mediated intermolecular reactions are suppressed by complex formation of the divalent metal ion and citrate with oxytocin, thereby inhibiting the formation of citrate adducts and reactions of the cysteine thiol group in oxytocin.	Citric Acid	137-144	oxytocin/neurophysin I prepropeptide	Homo sapiens	150-158
22257021-11	2012	We therefore postulate that cysteine-mediated intermolecular reactions are suppressed by complex formation of the divalent metal ion and citrate with oxytocin, thereby inhibiting the formation of citrate adducts and reactions of the cysteine thiol group in oxytocin.	Citric Acid	137-144	oxytocin/neurophysin I prepropeptide	Homo sapiens	257-265
22257021-11	2012	We therefore postulate that cysteine-mediated intermolecular reactions are suppressed by complex formation of the divalent metal ion and citrate with oxytocin, thereby inhibiting the formation of citrate adducts and reactions of the cysteine thiol group in oxytocin.	Citric Acid	196-203	oxytocin/neurophysin I prepropeptide	Homo sapiens	150-158
22257021-11	2012	We therefore postulate that cysteine-mediated intermolecular reactions are suppressed by complex formation of the divalent metal ion and citrate with oxytocin, thereby inhibiting the formation of citrate adducts and reactions of the cysteine thiol group in oxytocin.	Citric Acid	196-203	oxytocin/neurophysin I prepropeptide	Homo sapiens	257-265
21660471-5	2012	One of the most important advances in understanding the molecular events associated with the Al exclusion mechanism was the identification of the ALMT1 gene (Al-activated malate transporter) in Triticum aestivum root cells, which codes for a plasma membrane anion channel that allows efflux of organic acid anions, such as malate, citrate or oxalate.	Citric Acid	331-338	aluminum-activated malate transporter 1	Triticum aestivum	146-151
22452130-1	2012	Regional citrate anticoagulation of the extracorporeal circuits (CRA) experienced considerable growth over the past decade.	Citric Acid	9-16	myotubularin related protein 11	Homo sapiens	65-68
22398801-5	2012	This is potentially due to defects in the renal tubular citrate carriers (NaDC 1 and 3) which may be genetically determined.	Citric Acid	56-63	solute carrier family 13 member 2	Homo sapiens	74-86
22080945-5	2012	RECENT FINDINGS: Metabolomic studies of IDH1/2 mutant cells have revealed alterations in glutamine, fatty acid, and citrate synthesis pathways.	Citric Acid	116-123	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	40-44
22031945-4	2012	Crystals of citrate in complex with the protruding domain from norovirus GII.10 Vietnam026 diffracted to 1.4 A and showed a single citrate bound at the site of HBGA interaction.	Citric Acid	12-19	hemoglobin subunit gamma 1	Homo sapiens	160-164
22031945-4	2012	Crystals of citrate in complex with the protruding domain from norovirus GII.10 Vietnam026 diffracted to 1.4 A and showed a single citrate bound at the site of HBGA interaction.	Citric Acid	131-138	hemoglobin subunit gamma 1	Homo sapiens	160-164
22031945-7	2012	STD NMR showed the protruding domain to have weak affinity for citrate (460 muM).	Citric Acid	63-70	latexin	Homo sapiens	76-79
23077570-4	2012	The Mcat-deficient phenotype is attributed primarily to reduced synthesis, in several tissues, of the octanoyl precursors required for the posttranslational lipoylation of pyruvate and alpha-ketoglutarate dehydrogenase complexes, resulting in diminished capacity of the citric acid cycle and disruption of energy metabolism.	Citric Acid	270-281	malonyl CoA:ACP acyltransferase (mitochondrial)	Mus musculus	4-8
22333045-7	2012	There was a significant difference (p &lt; 0.05) in the mean channel fluorescence intensity (MFI) of mCD14 on neutrophils in whole blood samples anticoagulated with HEPARIN (MFI = 64.77) in comparison with those in whole blood samples anticoagulated with either EDTA (MFI = 38.25) or CITRATE (MFI = 43.7).	Citric Acid	284-291	CD14 antigen	Mus musculus	101-106
22333045-8	2012	The MFI of mCD14 on monocytes in whole blood samples anticoagulted with HEPARIN (MFI = 206.90) was significantly higher than the MFI in whole blood samples anticoagulated with EDTA (MFI = 149.37) but similar to that with CITRATE (MFI = 162.55).	Citric Acid	221-228	CD14 antigen	Mus musculus	11-16
22333045-10	2012	However, MFI of mCD14 on monocytes was about 3.2-folds (HEPARIN), 3.9-folds (EDTA) or 3.7 folds (CITRATE) higher than those on neutrophils.	Citric Acid	97-104	CD14 antigen	Mus musculus	16-21
22371326-7	2012	The accumulating citrate enhances AOX capacity, expression, and protein abundance.	Citric Acid	17-24	alternative oxidase 2	Arabidopsis thaliana	34-37
22371326-10	2012	The findings show that NO inhibits aconitase under hypoxia which results in accumulation of citrate, the latter in turn inducing AOX and causing a shift of metabolism towards amino acid biosynthesis.	Citric Acid	92-99	alternative oxidase 2	Arabidopsis thaliana	129-132
22848174-2	2012	We have developed SPIONs capped with citric acid/2-bromo-2-methylpropionic acid which are compact, water dispersible, biocompatible having narrow range of size dispersity (8-10 nm), and relatively high T2 relaxivity (R2 = 222L   mmol-1   sec-1).	Citric Acid	37-48	secretory blood group 1, pseudogene	Homo sapiens	238-243
22156800-0	2011	Human prostate cancer ZIP1/zinc/citrate genetic/metabolic relationship in the TRAMP prostate cancer animal model.	Citric Acid	32-39	zinc finger BED-type containing 1	Homo sapiens	78-83
22485150-3	2012	Citrate synthase (CS) is a key enzyme of the citric acid cycle that provides energy for cellular function.	Citric Acid	45-56	citrate synthase	Mus musculus	0-16
22485150-3	2012	Citrate synthase (CS) is a key enzyme of the citric acid cycle that provides energy for cellular function.	Citric Acid	45-56	citrate synthase	Mus musculus	18-20
22485150-4	2012	Additionally, CS plays a critical role in providing citrate derived acetyl-CoA for lipogenesis and cholesterologenesis.	Citric Acid	52-59	citrate synthase	Mus musculus	14-16
22156800-6	2011	The results show that citrate levels are markedly decreased in the developing and advancing stages of malignancy in TRAMP.	Citric Acid	22-29	zinc finger BED-type containing 1	Homo sapiens	116-121
22156800-11	2011	It now appears that the TRAMP model will be suitable for studies relating to the implications and role of zinc- and citrate-related metabolism in the development and progression of human prostate cancer.	Citric Acid	116-123	zinc finger BED-type containing 1	Homo sapiens	24-29
21556928-0	2011	Expression of the H+-ATPase AHA10 proton pump is associated with citric acid accumulation in lemon juice sac cells.	Citric Acid	65-76	autoinhibited H[+]-ATPase 	Arabidopsis thaliana	28-33
22106302-6	2011	Glutamine-derived alpha-ketoglutarate is reductively carboxylated by the NADPH-linked mitochondrial isocitrate dehydrogenase (IDH2) to form isocitrate, which can then be isomerized to citrate.	Citric Acid	103-110	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	126-130
21963157-10	2011	The citrate-modified photo-Fenton system may be suitable for in vivo applications of resilin biomaterials.	Citric Acid	4-11	resilin	Drosophila melanogaster	85-92
22107692-2	2011	This is the first study conducted to examine the potentially additive benefit effect of regional citrate anticoagulation (RCA) on polymorphonuclear (PMN) cell degranulation of myeloperoxidase (MPO) and cytokines production in patients with critically acute kidney injury (AKI) undergoing CVVH treatment.	Citric Acid	97-104	myeloperoxidase	Homo sapiens	176-191
22005676-6	2011	Moreover, bilateral Na(V)1.7 shRNA injected animals survived for several months and the vagal reflex behaviour, exemplified by citric acid-induced coughing, was significantly suppressed.	Citric Acid	127-138	neuron navigator 1	Cavia porcellus	20-26
22506410-1	2011	Phosphoenolpyruvate carboxylase (PEPC, EC 4.1.1.31) is an important ubiquitous cytosol enzyme that fixes HCO3 together with phosphoenolpyruvate (PEP) and yields oxaloacetate that can be converted to intermediates of the citric acid cycle.	Citric Acid	220-231	phosphoenolpyruvate carboxykinase 1	Homo sapiens	0-31
22506410-1	2011	Phosphoenolpyruvate carboxylase (PEPC, EC 4.1.1.31) is an important ubiquitous cytosol enzyme that fixes HCO3 together with phosphoenolpyruvate (PEP) and yields oxaloacetate that can be converted to intermediates of the citric acid cycle.	Citric Acid	220-231	phosphoenolpyruvate carboxykinase 1	Homo sapiens	33-37
22107692-2	2011	This is the first study conducted to examine the potentially additive benefit effect of regional citrate anticoagulation (RCA) on polymorphonuclear (PMN) cell degranulation of myeloperoxidase (MPO) and cytokines production in patients with critically acute kidney injury (AKI) undergoing CVVH treatment.	Citric Acid	97-104	myeloperoxidase	Homo sapiens	193-196
22107692-8	2011	Citrate could significantly decrease systemic pre-filter serum MPO levels from baseline at 6 h (median 43.5 vs. 17.3 ng/mL, P&lt;0.01) as well as IL-8 levels (P&lt;0.05) whereas heparin provided only significant TNF-alpha reduction (P&lt;0.05).	Citric Acid	0-7	myeloperoxidase	Homo sapiens	63-66
22107692-8	2011	Citrate could significantly decrease systemic pre-filter serum MPO levels from baseline at 6 h (median 43.5 vs. 17.3 ng/mL, P&lt;0.01) as well as IL-8 levels (P&lt;0.05) whereas heparin provided only significant TNF-alpha reduction (P&lt;0.05).	Citric Acid	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
22107692-8	2011	Citrate could significantly decrease systemic pre-filter serum MPO levels from baseline at 6 h (median 43.5 vs. 17.3 ng/mL, P&lt;0.01) as well as IL-8 levels (P&lt;0.05) whereas heparin provided only significant TNF-alpha reduction (P&lt;0.05).	Citric Acid	0-7	tumor necrosis factor	Homo sapiens	212-221
21829838-3	2011	Additionally, chemosensor 2 (c = 6.29 x 10(-3) M) forms a stable gel only with citrate in CH(3)CN, which validates its visual sensing.	Citric Acid	79-86	complement C6	Homo sapiens	29-34
21921028-6	2011	CPO displayed a neutral pH optimum and was inhibited by common metallocarboxypeptidase inhibitors as well as citrate.	Citric Acid	109-116	carboxypeptidase O	Homo sapiens	0-3
21742986-3	2011	Consistently, frd3 loss-of-function mutants are defective in early germination and are almost completely sterile, both defects being rescued by iron and/or citrate supply.	Citric Acid	156-163	MATE efflux family protein	Arabidopsis thaliana	14-18
21841001-6	2011	Concomitantly, co-disruption of the RTG1 gene reduced the cellular levels of succinate in the sdh2Delta and fum1Delta strains, of fumarate in the fum1Delta strain, and citrate in an idhDelta strain.	Citric Acid	168-175	Rtg1p	Saccharomyces cerevisiae S288C	36-40
21757732-7	2011	A computational approach was used to analyze in vivo metabolomic as well as transcriptomic data from wild-type and OAT1 knock-out animals, resulting in the implication of several metabolic pathways, including the citric acid cycle, polyamine, and fatty acid metabolism.	Citric Acid	213-224	solute carrier family 22 member 6	Homo sapiens	115-119
21547912-0	2011	Formation of amide- and imide-linked degradation products between the peptide drug oxytocin and citrate in citrate-buffered formulations.	Citric Acid	96-103	oxytocin/neurophysin I prepropeptide	Homo sapiens	83-91
21547912-0	2011	Formation of amide- and imide-linked degradation products between the peptide drug oxytocin and citrate in citrate-buffered formulations.	Citric Acid	107-114	oxytocin/neurophysin I prepropeptide	Homo sapiens	83-91
21547912-2	2011	In accelerated stability studies of the small cyclic peptide oxytocin, we have noted that additional degradation products form when oxytocin is formulated in citrate that do not form in other common buffers such as acetate and phosphate.	Citric Acid	158-165	oxytocin/neurophysin I prepropeptide	Homo sapiens	61-69
21547912-2	2011	In accelerated stability studies of the small cyclic peptide oxytocin, we have noted that additional degradation products form when oxytocin is formulated in citrate that do not form in other common buffers such as acetate and phosphate.	Citric Acid	158-165	oxytocin/neurophysin I prepropeptide	Homo sapiens	132-140
21547912-3	2011	Using high-pressure liquid chromatography combined with high-resolution and tandem mass spectrometry, we identified these degradation products as amide- and imide-linked adducts of oxytocin and citrate.	Citric Acid	194-201	oxytocin/neurophysin I prepropeptide	Homo sapiens	181-189
21547912-5	2011	The adducts have been found to form for oxytocin formulated in citrate buffer over the pH range of 3-6; the extent of formation is greatest at a pH of 4-4.5.	Citric Acid	63-70	oxytocin/neurophysin I prepropeptide	Homo sapiens	40-48
21547912-6	2011	We have additionally identified these same adducts in samples of oxytocin formulated in citrate buffer that had been stored in the dark for 3 months at room temperature.	Citric Acid	88-95	oxytocin/neurophysin I prepropeptide	Homo sapiens	65-73
21547912-7	2011	Altogether, these results demonstrate that reaction between citrate and oxytocin leads to the formation of covalent amide- and imide-linked adducts.	Citric Acid	60-67	oxytocin/neurophysin I prepropeptide	Homo sapiens	72-80
21480413-3	2011	SMPS reduces the degree of liver injury by up-regulating the enzymes of the citric acid cycle, namely malate dehydrogenase (MDH) and 2-oxoglutarate dehydrogenase complex.	Citric Acid	76-87	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	102-122
21480413-3	2011	SMPS reduces the degree of liver injury by up-regulating the enzymes of the citric acid cycle, namely malate dehydrogenase (MDH) and 2-oxoglutarate dehydrogenase complex.	Citric Acid	76-87	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	124-127
21854985-6	2011	Increasing cellular levels of acetyl-CoA by addition of acetate or citrate restores protein N-alpha-acetylation in Bcl-xL-expressing cells and confers sensitivity to apoptotic stimuli.	Citric Acid	67-74	BCL2 like 1	Homo sapiens	115-121
22016913-6	2011	RESULTS: The stabilized SnF2 toothpaste included in these studies demonstrated a highly significant reduction in enamel surface loss, relative to the control, in each study: Study 1 = 65% reduction; Study 2 = 58% reduction when using citric acid and 84% reduction when using phosphoric acid.	Citric Acid	234-245	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	24-28
21827592-7	2011	HEMOSTASIS TESTING: Citrate anticoagulated blood was collected for point-of-care testing with a viscoelastic monitor (thromboelastograph [TEG]) and citrate plasma was prepared for coagulation screening tests and specific assay of the following hemostatic proteins: antiplasmin, antithrombin, D-dimer, Factor VIII, fibrinogen, plasminogen, protein C, and von Willebrand factor.	Citric Acid	20-27	coagulation factor VIII	Canis lupus familiaris	301-312
21161647-11	2011	Results suggest that at least in mice (1) Increase in oxalate and decrease in citrate excretion can lead to CaOx crystalluria but not CaOx nephrolithiasis; (2) MCP-1 does not play a role in crystal retention within the kidneys; (3) Expression of OPN and MCP-1 is not increased in the kidneys in the absence of crystal deposition; (4) Crystal deposition is necessary for significant pathological changes and movement of monocytes and macrophages into the interstitium.	Citric Acid	78-85	chemokine (C-C motif) ligand 2	Mus musculus	160-165
21742986-7	2011	Based on the findings that iron acquisition in embryo, leaf, and pollen depends on FRD3, we propose that FRD3 mediated-citrate release in the apoplastic space represents an important process by which efficient iron nutrition is achieved between adjacent tissues lacking symplastic connections.	Citric Acid	119-126	MATE efflux family protein	Arabidopsis thaliana	83-87
21742986-7	2011	Based on the findings that iron acquisition in embryo, leaf, and pollen depends on FRD3, we propose that FRD3 mediated-citrate release in the apoplastic space represents an important process by which efficient iron nutrition is achieved between adjacent tissues lacking symplastic connections.	Citric Acid	119-126	MATE efflux family protein	Arabidopsis thaliana	105-109
21698747-4	2011	In the presence of aldolase, PFK is not modulated by its allosteric activators, ADP and fructose-2,6-bisphosphate, but is still inhibited by citrate and lactate.	Citric Acid	141-148	phosphofructokinase, muscle	Homo sapiens	29-32
20711769-6	2011	The working range was 3 nM to 10 muM for citric acid, 158 nM to 10 muM for fumaric acid, 34 nM to 10 muM for malic acid, 33 nM to 10 muM for malonic acid, 53 nM to 10 muM for oxalic acid, 48 nM to 10 muM for succinic acid, and 6 nM to 10 muM for aconitic acid.	Citric Acid	41-52	latexin	Homo sapiens	33-36
21623810-2	2011	METHODS: Dentine discs were prepared from extracted caries-free human third molars and etched with 0.02 M citric acid (pH 4) for 3 minutes in order to produce patent dentinal tubules.	Citric Acid	106-117	prolyl 4-hydroxylase, transmembrane	Homo sapiens	119-123
21073858-1	2011	Citric acid cycle intermediates, including succinate and citrate, are absorbed across the apical membrane by the NaDC1 Na+/dicarboxylate cotransporter located in the kidney and small intestine.	Citric Acid	0-11	solute carrier family 13 member 2	Homo sapiens	113-118
21073858-1	2011	Citric acid cycle intermediates, including succinate and citrate, are absorbed across the apical membrane by the NaDC1 Na+/dicarboxylate cotransporter located in the kidney and small intestine.	Citric Acid	57-64	solute carrier family 13 member 2	Homo sapiens	113-118
21643438-3	2011	Mouse L-PGDS with a C65A mutation was previously crystallized with citrate or malonate as a precipitant, and the X-ray crystallographic structure was determined at 2.0 A resolution.	Citric Acid	67-74	prostaglandin D2 synthase (brain)	Mus musculus	6-12
21392885-4	2011	The extent of degradation followed the trend: TBP-EDTA-citric acid greater than TBP-EDTA, greater than TBP alone.	Citric Acid	55-66	TATA-box binding protein	Homo sapiens	46-49
21770132-3	2011	The results showed that variation of citric acid concentration directly influences the particle size and the BET specific surface area.	Citric Acid	37-48	delta/notch like EGF repeat containing	Homo sapiens	109-112
21624077-10	2011	The total/ionized calcium ratio (1.87 +- 0.22 before vs. 1.56 +- 0.20 after 6 h) and the corrected/ionized calcium ratio (2.02 +- 0.21 before vs. 1.88 +- 0.27 after 6 h) decreased during HDF, indicating no citrate accumulation.	Citric Acid	206-213	heart and neural crest derivatives expressed 1	Homo sapiens	1-2
21624077-11	2011	Citrate anticoagulation was effectively performed during 8 h of HCO membrane HDF.	Citric Acid	0-7	heart and neural crest derivatives expressed 1	Homo sapiens	59-60
21506536-7	2011	It is shown that IGF-1 adsorbs onto the surface of citrate-coated magnetite nanoparticles, and adsorption is confirmed by dot-blot analysis.	Citric Acid	51-58	insulin like growth factor 1	Homo sapiens	17-22
21506536-8	2011	In addition, it is also demonstrated that the external layer of IGF-1 exerts a shielding effect on the surface charge of citrate-magnetite particles, as suggested by the mobility reduction upon contacting the particles with the hormone.	Citric Acid	121-128	insulin like growth factor 1	Homo sapiens	64-69
20379854-4	2011	In dependence on the conditions, penetration was as follows: 30.3-95.2% of calcium ions from fumarate solution; 73.0-90.1% of Ca(II) from citrate solution; and 19.0-95.0% of Ca from gluconate solution.	Citric Acid	138-145	carbonic anhydrase 2	Homo sapiens	126-132
21573193-8	2011	Based on limited proteolytic digestion of the rabbit muscle PFK-M, an active citrate inhibition-resistant shorter form was obtained, indicating that a single posttranslational modification step was possible.	Citric Acid	77-84	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	60-65
21422166-2	2011	The aim of this study was to noninvasively assess uptake of citrate coated very small iron oxide particles at different stages of plaque development in the brachiocephalic artery of apoE(-/-) mice.	Citric Acid	60-67	apolipoprotein E	Mus musculus	182-186
21315475-4	2011	The higher concentrations of malate and citrate were accompanied by increased activities of phosphoenolpyruvate carboxylase (PEPC), phosphoenolpyruvate phosphatase (PEPP), citrate synthase (CS) and NAD-malic enzyme (NAD-ME) and decreased activities of pyruvate kinase (PK), NADP-ME and NADP-isocitrate dehydrogenase (NADP-IDH) in roots.	Citric Acid	40-47	phosphoenolpyruvate carboxykinase 1	Homo sapiens	92-123
21315475-4	2011	The higher concentrations of malate and citrate were accompanied by increased activities of phosphoenolpyruvate carboxylase (PEPC), phosphoenolpyruvate phosphatase (PEPP), citrate synthase (CS) and NAD-malic enzyme (NAD-ME) and decreased activities of pyruvate kinase (PK), NADP-ME and NADP-isocitrate dehydrogenase (NADP-IDH) in roots.	Citric Acid	40-47	phosphoenolpyruvate carboxykinase 1	Homo sapiens	125-129
21315475-4	2011	The higher concentrations of malate and citrate were accompanied by increased activities of phosphoenolpyruvate carboxylase (PEPC), phosphoenolpyruvate phosphatase (PEPP), citrate synthase (CS) and NAD-malic enzyme (NAD-ME) and decreased activities of pyruvate kinase (PK), NADP-ME and NADP-isocitrate dehydrogenase (NADP-IDH) in roots.	Citric Acid	40-47	citrate synthase	Homo sapiens	172-188
21315475-4	2011	The higher concentrations of malate and citrate were accompanied by increased activities of phosphoenolpyruvate carboxylase (PEPC), phosphoenolpyruvate phosphatase (PEPP), citrate synthase (CS) and NAD-malic enzyme (NAD-ME) and decreased activities of pyruvate kinase (PK), NADP-ME and NADP-isocitrate dehydrogenase (NADP-IDH) in roots.	Citric Acid	40-47	citrate synthase	Homo sapiens	190-192
21315475-4	2011	The higher concentrations of malate and citrate were accompanied by increased activities of phosphoenolpyruvate carboxylase (PEPC), phosphoenolpyruvate phosphatase (PEPP), citrate synthase (CS) and NAD-malic enzyme (NAD-ME) and decreased activities of pyruvate kinase (PK), NADP-ME and NADP-isocitrate dehydrogenase (NADP-IDH) in roots.	Citric Acid	40-47	malic enzyme 2	Homo sapiens	198-214
21315475-4	2011	The higher concentrations of malate and citrate were accompanied by increased activities of phosphoenolpyruvate carboxylase (PEPC), phosphoenolpyruvate phosphatase (PEPP), citrate synthase (CS) and NAD-malic enzyme (NAD-ME) and decreased activities of pyruvate kinase (PK), NADP-ME and NADP-isocitrate dehydrogenase (NADP-IDH) in roots.	Citric Acid	40-47	malic enzyme 2	Homo sapiens	216-222
21315475-4	2011	The higher concentrations of malate and citrate were accompanied by increased activities of phosphoenolpyruvate carboxylase (PEPC), phosphoenolpyruvate phosphatase (PEPP), citrate synthase (CS) and NAD-malic enzyme (NAD-ME) and decreased activities of pyruvate kinase (PK), NADP-ME and NADP-isocitrate dehydrogenase (NADP-IDH) in roots.	Citric Acid	40-47	malic enzyme 1	Homo sapiens	274-281
21105859-0	2011	Establishment of simultaneous treatment model with citrate for preventing nephropathy induced by FYX-051, a xanthine oxidoreductase inhibitor, in rats.	Citric Acid	51-58	xanthine dehydrogenase	Rattus norvegicus	108-131
21257749-0	2011	Synthesis, maturation, and trafficking of human Na+-dicarboxylate cotransporter NaDC1 requires the chaperone activity of cyclophilin B. Renal excretion of citrate, an inhibitor of calcium stone formation, is controlled mainly by reabsorption via the apical Na(+)-dicarboxylate cotransporter NaDC1 (SLC13A2) in the proximal tubule.	Citric Acid	155-162	solute carrier family 13 member 2	Homo sapiens	80-85
21257749-0	2011	Synthesis, maturation, and trafficking of human Na+-dicarboxylate cotransporter NaDC1 requires the chaperone activity of cyclophilin B. Renal excretion of citrate, an inhibitor of calcium stone formation, is controlled mainly by reabsorption via the apical Na(+)-dicarboxylate cotransporter NaDC1 (SLC13A2) in the proximal tubule.	Citric Acid	155-162	solute carrier family 13 member 2	Homo sapiens	291-296
21257749-0	2011	Synthesis, maturation, and trafficking of human Na+-dicarboxylate cotransporter NaDC1 requires the chaperone activity of cyclophilin B. Renal excretion of citrate, an inhibitor of calcium stone formation, is controlled mainly by reabsorption via the apical Na(+)-dicarboxylate cotransporter NaDC1 (SLC13A2) in the proximal tubule.	Citric Acid	155-162	solute carrier family 13 member 2	Homo sapiens	298-305
21257749-4	2011	While FK-506 had no effect, CsA reduced NaDC1-mediated citrate transport by lowering heterologous carrier expression (as well as endogenous carrier expression in HEK293 cells), indicating that calcineurin is not involved.	Citric Acid	55-62	solute carrier family 13 member 2	Homo sapiens	40-45
21257749-7	2011	We have thus identified for the first time a regulatory partner for NaDC1, and have gained novel mechanistic insight into the effect of CsA on renal citrate transport and kidney stone disease, as well as into the regulation of membrane transporters in general.	Citric Acid	149-156	solute carrier family 13 member 2	Homo sapiens	68-73
21192320-5	2011	Caspase-3 siRNA was administered directly into the renal artery in hyperosmolar citrate solution (3 mug/ml) with the renal vein clamped and into autologous blood (0.15 mug/ml), both of which were stored for 24 hr on ice.	Citric Acid	80-87	caspase 3	Homo sapiens	0-9
21498699-7	2011	RESULTS: A 3-day continuous exposure to citrate led to near destruction of the cell population in both cell lines, apoptotic cell death occurred through the mitochondrial pathway in a dose- and time-dependent manner, associated with the reduction of the anti-apoptotic Mcl-1 protein in both lines.	Citric Acid	40-47	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	269-274
21498699-8	2011	CONCLUSION: Citrate demonstrates strong cytotoxic activity against two gastric cancer lines, leading to an early diminution of expression of Mcl-1 and to massive apoptotic cell death involving the mitochondrial pathway.	Citric Acid	12-19	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	141-146
21439216-8	2011	The purpose of this study was to evaluate the effectiveness of an NK1 receptor antagonist, maropitant citrate, as a treatment for murine UD.	Citric Acid	102-109	tachykinin receptor 1	Mus musculus	66-78
21123491-2	2011	The major transporter to reabsorb citrate is Na(+)-dicarboxylate cotransporter (NaDC1), which transports dicarboxylates, including the divalent form of citrate.	Citric Acid	34-41	solute carrier family 13 member 2	Oryctolagus cuniculus	80-85
21123491-2	2011	The major transporter to reabsorb citrate is Na(+)-dicarboxylate cotransporter (NaDC1), which transports dicarboxylates, including the divalent form of citrate.	Citric Acid	152-159	solute carrier family 13 member 2	Oryctolagus cuniculus	80-85
20949348-10	2011	CONCLUSIONS/INTERPRETATION: Malate transport by DIC may play an important role in GSIS, possibly by providing cytosolic malate as a counter-substrate for citrate and/or isocitrate export by CIC.	Citric Acid	154-161	solute carrier family 25 member 10	Rattus norvegicus	48-51
21143371-1	2011	BACKGROUND: The citric cycle intermediate succinate has recently been identified as a ligand for the G-protein-coupled receptor (GPCR) SUCNR1.	Citric Acid	16-22	succinate receptor 1	Homo sapiens	135-141
22105806-7	2011	Additionally, decreased Erk signaling in matrix-detached cells causes a disproportionate decrease in flux through pyruvate dehydrogenase (PDH), leading to decreased entry of glucose carbons into the citric acid cycle.	Citric Acid	199-210	mitogen-activated protein kinase 1	Homo sapiens	24-27
22105806-7	2011	Additionally, decreased Erk signaling in matrix-detached cells causes a disproportionate decrease in flux through pyruvate dehydrogenase (PDH), leading to decreased entry of glucose carbons into the citric acid cycle.	Citric Acid	199-210	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	114-136
22105806-7	2011	Additionally, decreased Erk signaling in matrix-detached cells causes a disproportionate decrease in flux through pyruvate dehydrogenase (PDH), leading to decreased entry of glucose carbons into the citric acid cycle.	Citric Acid	199-210	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	138-141
19932013-13	2011	Serum testosterone, estradiol, PAcP, citric acid levels, AR and ER-alpha expressions were significantly decreased while H(2)O(2) generation, LPO, ER-beta were increased in PCB-exposed animals.	Citric Acid	37-48	pyruvate carboxylase	Rattus norvegicus	172-175
20607720-1	2011	BACKGROUND: Mitochondrial aconitase (mACON) is regarded as the key enzyme in citrate oxidation in human prostate epithelial cells, and its abnormal expression has been implicated in tumorigenesis of the prostate.	Citric Acid	77-84	aconitase 2	Homo sapiens	12-35
20866109-2	2010	Intracellular free [Mg2+] can be estimated by measurements of [citrate]/[isocitrate], a ratio known to vary with tissue free [Mg2+].	Citric Acid	63-70	mucin 7, secreted	Homo sapiens	20-23
20866109-2	2010	Intracellular free [Mg2+] can be estimated by measurements of [citrate]/[isocitrate], a ratio known to vary with tissue free [Mg2+].	Citric Acid	63-70	mucin 7, secreted	Homo sapiens	126-129
21042731-1	2010	Both normal (PTN1A) and cancer (PC3) prostate cells produce high levels of L-lactate because of a low energy supply via the citric cycle and oxidative phosphorylation.	Citric Acid	124-130	chromobox 8	Homo sapiens	32-35
20876955-7	2010	Lactic acid- and citric acid-derived bioactive glasses (LBG, CBG) exhibited nanoscale surface morphology, relatively low surface areas and comparable apatite-forming bioactivity.	Citric Acid	17-28	glucosylceramidase beta 3 (gene/pseudogene)	Homo sapiens	61-64
20807508-1	2010	Pyruvate carboxylase (PC) is a mitochondrial enzyme that catalyses the carboxylation of pyruvate to oxaloacetate thereby allowing supplementation of citric acid cycle intermediates.	Citric Acid	149-160	pyruvate carboxylase	Homo sapiens	0-20
20807508-1	2010	Pyruvate carboxylase (PC) is a mitochondrial enzyme that catalyses the carboxylation of pyruvate to oxaloacetate thereby allowing supplementation of citric acid cycle intermediates.	Citric Acid	149-160	pyruvate carboxylase	Homo sapiens	22-24
21042593-6	2010	In contrast, Ets-1 down-regulates genes involved in the citric acid cycle, electron transport chain, and mitochondrial proteins.	Citric Acid	56-67	ETS proto-oncogene 1, transcription factor	Homo sapiens	13-18
20610529-1	2010	The sodium-coupled transport of citric acid cycle intermediates in the intestine and kidney is mediated by the Na(+)-dicarboxylate cotransporter, NaDC1.	Citric Acid	32-43	solute carrier family 13 member 2	Homo sapiens	146-151
20610529-2	2010	In the kidney, NaDC1 plays an important role in regulating succinate and citrate concentrations in the urine, which may have physiological consequences including the development of kidney stones.	Citric Acid	73-80	solute carrier family 13 member 2	Homo sapiens	15-20
21124851-0	2010	Evolution of allosteric citrate binding sites on 6-phosphofructo-1-kinase.	Citric Acid	24-31	phosphofructokinase, muscle	Homo sapiens	49-73
21124851-6	2010	Stricter inhibition of the PFK1 enzyme was needed during the evolution of multi-cellular organisms, and the most stringent control of PFK1 by citrate occurs in vertebrates.	Citric Acid	142-149	phosphofructokinase, muscle	Homo sapiens	27-31
21124851-6	2010	Stricter inhibition of the PFK1 enzyme was needed during the evolution of multi-cellular organisms, and the most stringent control of PFK1 by citrate occurs in vertebrates.	Citric Acid	142-149	phosphofructokinase, muscle	Homo sapiens	134-138
21124851-9	2010	Substitution of another residue at the citrate-binding site (D591V) of human PFK-M resulted in the complete loss of activity.	Citric Acid	39-46	phosphofructokinase, muscle	Homo sapiens	77-82
21045285-4	2010	Here, the 1.94 A resolution X-ray structure of bisphosphoglycerate mutase is presented, focusing on the dynamic nature of key ligand-binding residues and their interaction with the inhibitor citrate.	Citric Acid	191-198	bisphosphoglycerate mutase	Homo sapiens	47-73
21170875-3	2010	The activity of many transport processes involved in calcium, citrate and phosphate handling are sensitive to changes in systemic or local pH as shown for several phosphate transporters, the citrate transporter NaDC1 and the TRPV5 calcium channel.	Citric Acid	62-69	solute carrier family 13 member 2	Homo sapiens	211-216
21170875-3	2010	The activity of many transport processes involved in calcium, citrate and phosphate handling are sensitive to changes in systemic or local pH as shown for several phosphate transporters, the citrate transporter NaDC1 and the TRPV5 calcium channel.	Citric Acid	62-69	transient receptor potential cation channel subfamily V member 5	Homo sapiens	225-230
21170889-6	2010	Acid-base status is the most important physiological determinant of urinary citrate excretion, by modulating the activities of NaDC1 and cytoplasmic (ATP citrate lyase) and mitochondrial (m-aconitase) enzymes involved in citrate metabolism.	Citric Acid	76-83	solute carrier family 13 member 2	Homo sapiens	127-132
21170889-6	2010	Acid-base status is the most important physiological determinant of urinary citrate excretion, by modulating the activities of NaDC1 and cytoplasmic (ATP citrate lyase) and mitochondrial (m-aconitase) enzymes involved in citrate metabolism.	Citric Acid	76-83	ATP citrate lyase	Homo sapiens	150-167
20845974-1	2010	Sodium-coupled transport of citric acid cycle intermediates, such as succinate and citrate, is mediated by the NaDC1 transporter located on the apical membrane of kidney proximal tubule and small intestine cells.	Citric Acid	28-39	solute carrier family 13 member 2	Homo sapiens	111-116
20845974-1	2010	Sodium-coupled transport of citric acid cycle intermediates, such as succinate and citrate, is mediated by the NaDC1 transporter located on the apical membrane of kidney proximal tubule and small intestine cells.	Citric Acid	83-90	solute carrier family 13 member 2	Homo sapiens	111-116
20845974-2	2010	Our previous study showed that transmembrane helix (TM) 11 of NaDC1 is important for sodium and lithium binding, as well as for determining citrate affinity [Kahn and Pajor (1999) Biochemistry 38, 6151].	Citric Acid	140-147	solute carrier family 13 member 2	Homo sapiens	62-67
21049082-7	2010	By feeding the cells labeled glutamine, we also detected a "backwards" flux in the tricarboxylic acid cycle from alpha-ketoglutarate to citrate that was enhanced in contact-inhibited fibroblasts; this flux likely contributes to shuttling of NADPH from the mitochondrion to cytosol for redox defense or fatty acid synthesis.	Citric Acid	136-143	2,4-dienoyl-CoA reductase 1	Homo sapiens	241-246
20561451-6	2010	The results showed that compared with placebo group, infusion of citrate increased serum levels of OC and CTX (p &lt; 0.0001).	Citric Acid	65-72	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	106-109
20566322-5	2010	The key points in K-Ras4B preparation are low temperature expression and extraction of K-Ras4B from the insoluble fraction using a nucleotide loading procedure in the presence of Mg(2+) and citrate, a low affinity chelator.	Citric Acid	190-197	KRAS proto-oncogene, GTPase	Homo sapiens	18-25
20566322-5	2010	The key points in K-Ras4B preparation are low temperature expression and extraction of K-Ras4B from the insoluble fraction using a nucleotide loading procedure in the presence of Mg(2+) and citrate, a low affinity chelator.	Citric Acid	190-197	KRAS proto-oncogene, GTPase	Homo sapiens	87-94
20591941-7	2010	Compared with 24-h urine from the wild-type mice, that of THP-null mice is supersaturated with brushite (calcium phosphate), a stone precursor, and has reduced urinary excretion of citrate, a stone inhibitor.	Citric Acid	181-188	uromodulin	Mus musculus	58-61
20488800-1	2010	ATP-citrate lyase (ACL) is a key lipogenic enzyme that converts citrate in the cytoplasm to acetyl-CoA, the initial precursor that yields malonyl-CoA for fatty acid biosynthesis.	Citric Acid	4-11	ATP citrate lyase	Mus musculus	19-22
20488800-2	2010	As cytosolic citrate is derived from the tricarboxylic acid cycle in the mitochondrion, ACL catalyzes a critical reaction linking cellular glucose catabolism and lipid synthesis.	Citric Acid	13-20	ATP citrate lyase	Mus musculus	88-91
20693693-4	2010	The A-TIM crystals were grown in the presence of citrate, which is bound in the active site of each of the two molecules in the asymmetric unit.	Citric Acid	49-56	triosephosphate isomerase 1	Homo sapiens	6-9
20693693-6	2010	Extensive crystal-soaking protocols have been developed to flush the bound citrate out of the active-site pocket of both molecules and the crystal structure shows that the unliganded open conformation of the A-TIM active site is the same as in unliganded wild-type TIM.	Citric Acid	75-82	triosephosphate isomerase 1	Homo sapiens	210-213
20693693-6	2010	Extensive crystal-soaking protocols have been developed to flush the bound citrate out of the active-site pocket of both molecules and the crystal structure shows that the unliganded open conformation of the A-TIM active site is the same as in unliganded wild-type TIM.	Citric Acid	75-82	triosephosphate isomerase 1	Homo sapiens	265-268
20856820-0	2010	Ghrelin is produced in taste cells and ghrelin receptor null mice show reduced taste responsivity to salty (NaCl) and sour (citric acid) tastants.	Citric Acid	124-135	ghrelin	Mus musculus	0-7
20856820-0	2010	Ghrelin is produced in taste cells and ghrelin receptor null mice show reduced taste responsivity to salty (NaCl) and sour (citric acid) tastants.	Citric Acid	124-135	growth hormone secretagogue receptor	Mus musculus	39-55
20856820-7	2010	GHSR null mice exhibited significantly reduced taste responsivity to sour (citric acid) and salty (sodium chloride) tastants.	Citric Acid	75-86	growth hormone secretagogue receptor	Mus musculus	0-4
20598931-1	2010	Pyruvate carboxylase (PC) is a regulated mitochondrial enzyme that catalyzes the conversion of pyruvate to oxaloacetate, a critical transition that replenishes citric acid cycle intermediates and facilitates other biosynthetic reactions that drive anabolism.	Citric Acid	160-171	pyruvate carboxylase	Homo sapiens	0-20
20598931-1	2010	Pyruvate carboxylase (PC) is a regulated mitochondrial enzyme that catalyzes the conversion of pyruvate to oxaloacetate, a critical transition that replenishes citric acid cycle intermediates and facilitates other biosynthetic reactions that drive anabolism.	Citric Acid	160-171	pyruvate carboxylase	Homo sapiens	22-24
20558738-0	2010	Identification of the citrate-binding site of human ATP-citrate lyase using X-ray crystallography.	Citric Acid	22-29	ATP citrate lyase	Homo sapiens	52-69
20558738-1	2010	ATP-citrate lyase (ACLY) catalyzes the conversion of citrate and CoA into acetyl-CoA and oxaloacetate, coupled with the hydrolysis of ATP.	Citric Acid	4-11	ATP citrate lyase	Homo sapiens	19-23
21032899-4	2010	The superoxide dismutase and catalase activities increased in at experimental toxic hepatitis, tended towards control values after citrate administration.	Citric Acid	131-138	catalase	Rattus norvegicus	29-37
20371607-5	2010	Its transport properties, kinetic parameters, and targeting to mitochondria show that Yhm2p is a mitochondrial transporter for citrate and oxoglutarate.	Citric Acid	127-134	Yhm2p	Saccharomyces cerevisiae S288C	86-91
20371607-7	2010	Yhm2p catalyzed only a counter-exchange transport that was saturable and inhibited by sulfhydryl-blocking reagents but not by 1,2,3-benzenetricarboxylate (a powerful inhibitor of the citrate/malate carrier).	Citric Acid	183-190	Yhm2p	Saccharomyces cerevisiae S288C	0-5
20561451-9	2010	Infusion of citrate also induced profound increase in serum (i)PTH level (p &lt; 0.0001) and urinary calcium excretion (p &lt; 0.0001), and decrease in serum (i)Ca(2+) (p &lt; 0.0001) and P(i) (p &lt; 0.01) levels.	Citric Acid	12-19	parathyroid hormone	Homo sapiens	63-66
19795461-5	2010	The enzyme that breaks down cytosolic citric acid is ATP citrate lyase (ACLY).	Citric Acid	38-49	ATP citrate lyase	Homo sapiens	53-70
21488266-1	2010	The synthesis, structure and magnetic properties of a 3D network based on {Co4(cit)4}8- (H4cit = citric acid) cubane units linked by octahedral Co(II) centres is reported.	Citric Acid	97-108	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-150
20457939-3	2010	Here, we show that MIG12, a 22 kDa cytosolic protein of previously unknown function, binds to ACC and lowers the threshold for citrate activation into the physiological range (&lt; 1 mM).	Citric Acid	127-134	thymosin beta 10	Homo sapiens	19-24
20457939-4	2010	In vitro, recombinant MIG12 induced polymerization of ACC (as determined by nondenaturing gels, FPLC, and electron microscopy) and increased ACC activity by &gt; 50-fold in the presence of 1 mM citrate.	Citric Acid	194-201	thymosin beta 10	Homo sapiens	22-27
19795461-5	2010	The enzyme that breaks down cytosolic citric acid is ATP citrate lyase (ACLY).	Citric Acid	38-49	ATP citrate lyase	Homo sapiens	72-76
20153162-2	2010	This system is based on the noncrosslinking aggregation mechanism with a cationic protein kinase C (PKC) alpha-specific peptide substrate, which is used as a coagulant of citrate-coated GNP with anionic surface charges.	Citric Acid	171-178	protein kinase C alpha	Homo sapiens	100-103
20078130-7	2010	The gelation of PAH begins with the formation of colloidal aggregates of PAH and citrate, which then combine under shear flow to form noncontinuous or continuous gels.	Citric Acid	81-88	phenylalanine hydroxylase	Homo sapiens	16-19
20203136-5	2010	Competitive assays of binding of Cd(2+) to transferrin in the presence of citrate and human serum albumin at molar ratios corresponding to those found in normal plasma showed that a considerable amount of Cd(2+) was not bound to transferrin.	Citric Acid	74-81	transferrin	Homo sapiens	43-54
20003133-10	2010	[(14)C]-citrate efflux experiments in oocytes demonstrate that ZmMATE1 is a citrate transporter.	Citric Acid	8-15	Protein DETOXIFICATION 42	Zea mays	63-70
20026031-6	2010	Citrate/oxaloacetate appearance outside mitochondria also occurred as result of PEP addition to PLM.	Citric Acid	0-7	Sodium/potassium-transporting ATPase subunit FXYD1	Sus scrofa	96-99
19965590-8	2010	Knockdown of ATP-citrate lyase, which converts citrate to acetyl-CoA, decreased histone acetylation and attenuated glucose induction of CYP7A1 mRNA expression.	Citric Acid	17-24	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	136-142
20063412-4	2010	Consistent with this proposed function, Mdh2 mutants have significantly lower levels of ATP and accumulate late-stage citric acid cycle intermediates, suggesting that the cell death defects arise from a deficit in energy production.	Citric Acid	118-129	Malate dehydrogenase 2	Drosophila melanogaster	40-44
19508702-5	2009	RESULTS: Infusion of citrate resulted in increased serum levels of the bone formation marker osteocalcin (OC) and bone resorption marker C-telopeptide of type 1 collagen (CTX).	Citric Acid	21-28	bone gamma-carboxyglutamate protein	Homo sapiens	93-104
20026062-3	2010	At high substrate levels; PA oxidation was reduced while release of acid soluble metabolites was increased and, both glucose oxidation and release of citrate was increased which could be abolished by phenylacetic acid (inhibitor of pyruvate carboxylase (PC)).	Citric Acid	150-157	pyruvate carboxylase	Homo sapiens	232-252
20026062-3	2010	At high substrate levels; PA oxidation was reduced while release of acid soluble metabolites was increased and, both glucose oxidation and release of citrate was increased which could be abolished by phenylacetic acid (inhibitor of pyruvate carboxylase (PC)).	Citric Acid	150-157	pyruvate carboxylase	Homo sapiens	254-256
20832780-7	2010	AChE activity was increased by 50.7% in Al plus citrate and by 28.6% in Al groups, when compared to the control.	Citric Acid	48-55	acetylcholinesterase	Rattus norvegicus	0-4
20005400-1	2009	UNLABELLED: Citrate synthase (CS) is the one of the key enzymes in the citric acid cycle and an important mitochondrial autoantigen.	Citric Acid	71-82	citrate synthase	Rattus norvegicus	12-28
20005400-1	2009	UNLABELLED: Citrate synthase (CS) is the one of the key enzymes in the citric acid cycle and an important mitochondrial autoantigen.	Citric Acid	71-82	citrate synthase	Rattus norvegicus	30-32
19691484-0	2009	Comparison between hirudin and citrate in monitoring the inhibitory effects of P2Y12 receptor antagonists with different platelet function tests.	Citric Acid	31-38	purinergic receptor P2Y12	Homo sapiens	79-84
20018372-1	2010	GPR91 is an orphan G-protein-coupled receptor (GPCR) that has been characterized as a receptor for succinate, a citric acid cycle intermediate, in several tissues.	Citric Acid	112-123	succinate receptor 1	Rattus norvegicus	0-5
19733154-5	2009	We also observed that the activity of the mitochondrial enzyme citrate synthase from mitochondrial preparations and purified citrate synthase was significantly inhibited by D-Ser, whereas the other activities of the citric acid cycle as well as the activities of complexes I-III, II-III, II and IV of the respiratory chain, creatine kinase and Na(+),K(+)-ATPase were not affected by this D-amino acid.	Citric Acid	216-227	citrate synthase	Rattus norvegicus	63-79
19891767-13	2009	CONCLUSION: Our results identify a previously uncharacterized function of STAT1 in tumours: expressional regulation of genes encoding proteins involved in glycolysis, the citrate cycle and mitochondrial oxidative phosphorylation, with predominant regulation of glycolytic genes.	Citric Acid	171-178	signal transducer and activator of transcription 1	Homo sapiens	74-79
19833662-5	2009	In contrast, in brief access tests, P2X2/P2X3(Dbl-/-) mice avoided citric acid and hydrochloric acid at the same concentrations as their wild-type counterparts, indicating that these weak acids activate oropharyngeal chemoreceptors.	Citric Acid	67-78	purinergic receptor P2X, ligand-gated ion channel, 2	Mus musculus	36-40
19833662-5	2009	In contrast, in brief access tests, P2X2/P2X3(Dbl-/-) mice avoided citric acid and hydrochloric acid at the same concentrations as their wild-type counterparts, indicating that these weak acids activate oropharyngeal chemoreceptors.	Citric Acid	67-78	purinergic receptor P2X, ligand-gated ion channel, 3	Mus musculus	41-45
19654186-3	2009	Here, we show that mutations in the scheggia (sea)-encoded Sea protein, the Drosophila ortholog of the human mitochondrial citrate carrier Solute carrier 25 A1 (SLC25A1), impair citrate transport from mitochondria to the cytosol.	Citric Acid	123-130	solute carrier family 25 member 1	Homo sapiens	139-159
19654186-3	2009	Here, we show that mutations in the scheggia (sea)-encoded Sea protein, the Drosophila ortholog of the human mitochondrial citrate carrier Solute carrier 25 A1 (SLC25A1), impair citrate transport from mitochondria to the cytosol.	Citric Acid	123-130	solute carrier family 25 member 1	Homo sapiens	161-168
19654186-3	2009	Here, we show that mutations in the scheggia (sea)-encoded Sea protein, the Drosophila ortholog of the human mitochondrial citrate carrier Solute carrier 25 A1 (SLC25A1), impair citrate transport from mitochondria to the cytosol.	Citric Acid	178-185	solute carrier family 25 member 1	Homo sapiens	139-159
19654186-3	2009	Here, we show that mutations in the scheggia (sea)-encoded Sea protein, the Drosophila ortholog of the human mitochondrial citrate carrier Solute carrier 25 A1 (SLC25A1), impair citrate transport from mitochondria to the cytosol.	Citric Acid	178-185	solute carrier family 25 member 1	Homo sapiens	161-168
19631611-3	2009	Furthermore, metabolites such as arginine, glutamate, citrate, and oxalacetate also exerted a negative effect on the PII-NAGK complex formation in the presence of Mg-ATP.	Citric Acid	54-61	N-acetyl-l-glutamate kinase	Arabidopsis thaliana	121-125
19809738-2	2009	Furthermore, citrate has been demonstrated to be an important ligand for the non-transferrin bound iron (NTBI) pool occurring in the plasma of individuals suffering from iron-overload.	Citric Acid	13-20	transferrin	Homo sapiens	81-92
19428179-3	2009	The use of model solutions has allowed establishing that THM promotion is a rather general effect for polyols, citric and humic acids, while for some other substrates such as histidine and dicarboxylic acids the influence of the presence of Mg(2+) and Ca(2+) is negligible.	Citric Acid	111-117	THM	Homo sapiens	57-60
19286649-1	2009	ATP citrate lyase (ACL) is a cytosolic enzyme that catalyzes the synthesis of acetyl-CoA and oxaloacetate using citrate, CoA, and ATP as substrates and Mg(2+) as a necessary cofactor.	Citric Acid	4-11	ATP citrate lyase	Homo sapiens	19-22
19286649-8	2009	The current assay consists of 1) incubation of ACL enzyme with [(14)C]citrate and other substrates/cofactors CoA, ATP, and Mg(2+), 2) EDTA quench, 3) addition of MicroScint-O, the agent that specifically detects product [(14)C]acetyl-CoA, and 4) detection of signal by TopCount.	Citric Acid	70-77	ATP citrate lyase	Homo sapiens	47-50
19678691-1	2009	In this work, the adsorption of citric (2-hydroxypropane-1,2,3-tricarboxylic acid) and tricarballylic (propane-1,2,3-tricarboxylic acid) acids onto alpha-FeOOH (goethite) in aqueous suspensions was studied as a function of pH and total ligand concentration in 0.1 M NaCl at 25.0 degrees C, and the molecular structures of the surface complexes formed were analyzed by means of ATR-FTIR spectroscopy.	Citric Acid	32-38	ATR serine/threonine kinase	Homo sapiens	377-380
19911682-11	2009	Citrate seems able to reduce the expression of urinary osteopontin.	Citric Acid	0-7	secreted phosphoprotein 1	Homo sapiens	55-66
19329367-3	2009	MMA(V) and DMA(V) in a sample were allowed to react with citric acid (CiA).	Citric Acid	57-68	nuclear receptor coactivator 5	Homo sapiens	70-73
19497920-8	2009	However, exposure of guinea pigs to NGF immediately before citric acid inhalation resulted in a significant increase in the citric acid-induced cough and airway obstruction compared with vehicle-treated animals.	Citric Acid	59-70	beta-nerve growth factor	Cavia porcellus	36-39
19497920-8	2009	However, exposure of guinea pigs to NGF immediately before citric acid inhalation resulted in a significant increase in the citric acid-induced cough and airway obstruction compared with vehicle-treated animals.	Citric Acid	124-135	beta-nerve growth factor	Cavia porcellus	36-39
19445897-4	2009	In addition, FOXA1 silencing in INS-1 cells decreases not only CIC mRNA and protein but also the amount of citrate in the cytosol and glucose-stimulated insulin secretion.	Citric Acid	107-114	forkhead box A1	Rattus norvegicus	13-18
19514735-4	2009	Among the bL ligands, only lactate and citrate are able to bind VO(2+) in the presence of transferrin or albumin, the others not interacting at all.	Citric Acid	39-46	transferrin	Homo sapiens	90-101
19362365-3	2009	This material, an ion complex gel matrix (IC gel) consisting of collagen and a citric acid derivative, enabled it to associate with basic fibroblast growth factor (bFGF).	Citric Acid	79-90	fibroblast growth factor 2	Rattus norvegicus	132-162
19362365-3	2009	This material, an ion complex gel matrix (IC gel) consisting of collagen and a citric acid derivative, enabled it to associate with basic fibroblast growth factor (bFGF).	Citric Acid	79-90	fibroblast growth factor 2	Rattus norvegicus	164-168
19293334-8	2009	The increase in GSIS following ME1 overexpression in INS-1 832/13 cells did not alter the ATP-to-ADP ratio but was accompanied by increases in malate and citrate levels.	Citric Acid	154-161	malic enzyme 1	Rattus norvegicus	31-34
19293334-8	2009	The increase in GSIS following ME1 overexpression in INS-1 832/13 cells did not alter the ATP-to-ADP ratio but was accompanied by increases in malate and citrate levels.	Citric Acid	154-161	insulin 1	Rattus norvegicus	53-58
19293334-9	2009	Increased malate and citrate levels were also observed after INS-1 832/13 cells were treated with the malate-permeable analog dimethyl malate.	Citric Acid	21-28	insulin 1	Rattus norvegicus	61-66
19672256-6	2009	The different uPAR forms were measured in citrate plasma collected before endoscopical examination, using three different Time Resolved - Fluorescence Immuno Assays (TR-FIA"s).	Citric Acid	42-49	plasminogen activator, urokinase receptor	Homo sapiens	14-18
19342121-5	2009	In Arabidopsis thaliana, citrate is effluxed into the xylem by the ferric reductase defective3 (FRD3) protein.	Citric Acid	25-32	MATE efflux family protein	Arabidopsis thaliana	67-94
19342121-5	2009	In Arabidopsis thaliana, citrate is effluxed into the xylem by the ferric reductase defective3 (FRD3) protein.	Citric Acid	25-32	MATE efflux family protein	Arabidopsis thaliana	96-100
19719226-2	2009	Three different PGN probes are synthesized by direct adsorption of cytochrome c, albumin, or human serum onto citrate-capped GNPs.	Citric Acid	110-117	SPG7 matrix AAA peptidase subunit, paraplegin	Homo sapiens	16-19
19250982-7	2009	Moreover, CaM activates PFK in the presence of citrate and lactate, two inhibitory metabolites that induce the dimerization of PFK tetramers, as well as potentiate the stimulatory action of ADP and fructose-2,6-bisphosphate.	Citric Acid	47-54	phosphofructokinase, muscle	Homo sapiens	24-27
19250982-7	2009	Moreover, CaM activates PFK in the presence of citrate and lactate, two inhibitory metabolites that induce the dimerization of PFK tetramers, as well as potentiate the stimulatory action of ADP and fructose-2,6-bisphosphate.	Citric Acid	47-54	phosphofructokinase, muscle	Homo sapiens	127-130
19885010-3	2009	It is well known that aggregation of Abeta depends on its hydrophobicity, and thus, in order to increase the hydrophilicity of Abeta, we considered using citrate, an anionic surfactant with three carboxylic acid groups.	Citric Acid	154-161	amyloid beta precursor protein	Homo sapiens	37-42
19885010-3	2009	It is well known that aggregation of Abeta depends on its hydrophobicity, and thus, in order to increase the hydrophilicity of Abeta, we considered using citrate, an anionic surfactant with three carboxylic acid groups.	Citric Acid	154-161	amyloid beta precursor protein	Homo sapiens	127-132
19885010-4	2009	We hypothesized that citrate could reduce hydrophobicity and increase hydrophilicity of Abeta(1-40) molecules via hydrophilic/electrostatic interactions.	Citric Acid	21-28	amyloid beta precursor protein	Homo sapiens	88-93
19885010-5	2009	We found that citrate significantly inhibited Abeta(1-40) aggregation and significantly protected SH-SY5Y cell line against Abeta(1-40) aggregates-induced neurotoxicity.	Citric Acid	14-21	amyloid beta precursor protein	Homo sapiens	46-51
19885010-5	2009	We found that citrate significantly inhibited Abeta(1-40) aggregation and significantly protected SH-SY5Y cell line against Abeta(1-40) aggregates-induced neurotoxicity.	Citric Acid	14-21	amyloid beta precursor protein	Homo sapiens	124-129
19885010-7	2009	Th-T assays showed that citrate significantly inhibited Abeta(1-40) aggregation in a concentration-dependent manner (Th-T intensity: from 91.3% in 0.01 mM citrate to 82.1% in 1.0 mM citrate vs. 100.0% in Abeta(1-40) alone).	Citric Acid	24-31	amyloid beta precursor protein	Homo sapiens	56-61
19885010-7	2009	Th-T assays showed that citrate significantly inhibited Abeta(1-40) aggregation in a concentration-dependent manner (Th-T intensity: from 91.3% in 0.01 mM citrate to 82.1% in 1.0 mM citrate vs. 100.0% in Abeta(1-40) alone).	Citric Acid	24-31	amyloid beta precursor protein	Homo sapiens	204-209
19885010-8	2009	In cytotoxicity and viability assays, citrate reduced the toxicity of Abeta(1-40) in a concentration-dependent manner, in which the cytotoxicity decreased from 107.5 to 102.3% as compared with Abeta(1-40) aggregates alone treated cells (127.3%) and the cell viability increased from 84.6 to 93.8% as compared with the Abeta(1-40) aggregates alone treated cells (65.3%).	Citric Acid	38-45	amyloid beta precursor protein	Homo sapiens	70-75
19885010-8	2009	In cytotoxicity and viability assays, citrate reduced the toxicity of Abeta(1-40) in a concentration-dependent manner, in which the cytotoxicity decreased from 107.5 to 102.3% as compared with Abeta(1-40) aggregates alone treated cells (127.3%) and the cell viability increased from 84.6 to 93.8% as compared with the Abeta(1-40) aggregates alone treated cells (65.3%).	Citric Acid	38-45	amyloid beta precursor protein	Homo sapiens	193-198
19885010-9	2009	Furthermore, Hoechst 33342 staining showed that citrate (1.0 mM) suppressed Abeta(1-40) aggregates-induced apoptosis in the cells.	Citric Acid	48-55	amyloid beta precursor protein	Homo sapiens	76-81
19885010-10	2009	This study suggests that citrate can inhibit Abeta(1-40) aggregation and protect neurons from the apoptotic effects of Abeta(1-40) aggregates.	Citric Acid	25-32	amyloid beta precursor protein	Homo sapiens	45-50
19885010-10	2009	This study suggests that citrate can inhibit Abeta(1-40) aggregation and protect neurons from the apoptotic effects of Abeta(1-40) aggregates.	Citric Acid	25-32	amyloid beta precursor protein	Homo sapiens	119-124
19375412-9	2009	DRS with a customized library and quantitation database was able to clearly separate co-eluting compounds including those with very similar mass spectra such as citric acid and isocitric acid.	Citric Acid	161-172	sushi repeat containing protein X-linked	Homo sapiens	0-3
19482931-10	2009	We showed that AcsD, AcsA, and AcsC together are able to condense citrate, ethanolamine, 2,4-diaminobutyrate, and alpha-ketoglutarate into achromobactin.	Citric Acid	66-73	acsA	Pseudomonas syringae pv. syringae B728a	21-25
19285877-5	2009	At pH 6.0 citric acid is able to mobilize arsenate from the As-Fe-PGA network through the complexation of the Fe(III) polyions that leads to the release of As(V).	Citric Acid	10-21	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	156-161
19204147-2	2009	However, the citric acid cycle intermediate succinate was shown recently to be a ligand for the G-protein-coupled receptor GPR91.	Citric Acid	13-24	succinate receptor 1	Homo sapiens	123-128
19244229-9	2009	In the YscM1(-) and YscM2(-) mutants, increased rates of pyruvate formation via glycolysis or the Entner-Doudoroff pathway, of oxaloacetate formation via the citrate cycle, and of amino acid biosynthesis suggest that both regulators trigger the central metabolism of Y. enterocolitica.	Citric Acid	158-165	yscM1	Yersinia enterocolitica	7-12
19244229-9	2009	In the YscM1(-) and YscM2(-) mutants, increased rates of pyruvate formation via glycolysis or the Entner-Doudoroff pathway, of oxaloacetate formation via the citrate cycle, and of amino acid biosynthesis suggest that both regulators trigger the central metabolism of Y. enterocolitica.	Citric Acid	158-165	yscM2	Yersinia enterocolitica	20-25
19246647-1	2009	IDH1 encodes isocitrate dehydrogenase 1, which participates in the citric acid cycle and was recently reported to be mutated in 12% of glioblastomas.	Citric Acid	67-78	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-4
19132743-0	2009	Small molecule clearance in ultrafiltration/diafiltration in relation to protein interactions:Study of citrate binding to a Fab.	Citric Acid	103-110	FA complementation group B	Homo sapiens	124-127
19359783-2	2009	In a pH 7.8 citric acid-Na(2)HPO(4) buffer solution and in the presence of polyethylene glycol (PEG), an immunoreaction between AuGCP and CP took place, and the released nanogold particles aggregated to bigger clusters, which caused the resonance scattering (RS) intensity at 552 nm (I(552nm)) to be enhanced greatly.	Citric Acid	12-23	ceruloplasmin	Homo sapiens	131-133
19414371-3	2009	RESULTS: A 3-day continuous exposure to citrate led to apoptotic cell death via a mitochondrial pathway, associated with a reduction of anti-apoptotic protein Bcl-x(L) and Mcl-1 expression.	Citric Acid	40-47	BCL2 like 1	Homo sapiens	159-167
19414371-3	2009	RESULTS: A 3-day continuous exposure to citrate led to apoptotic cell death via a mitochondrial pathway, associated with a reduction of anti-apoptotic protein Bcl-x(L) and Mcl-1 expression.	Citric Acid	40-47	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	172-177
19414371-6	2009	CONCLUSION: Depletion of ATP, diminution of the expression of the anti-apoptotic proteins and inhibition of hexokinase secondary to inhibition of phosphofructokinase by citrate may explain the cytotoxic activity of this molecule and its synergistic effect with cisplatin.	Citric Acid	169-176	hexokinase 1	Homo sapiens	108-118
18571954-7	2009	Citric acid perfusion marginally increased NGF levels to 7.3 fg/microg/ml on average in the upper arm and control axilla.	Citric Acid	0-11	nerve growth factor	Homo sapiens	43-46
18571954-9	2009	In contrast, perfusion of the inflamed axilla with citric acid significantly enhanced the release of both NGF and BDNF.	Citric Acid	51-62	nerve growth factor	Homo sapiens	106-109
18571954-9	2009	In contrast, perfusion of the inflamed axilla with citric acid significantly enhanced the release of both NGF and BDNF.	Citric Acid	51-62	brain derived neurotrophic factor	Homo sapiens	114-118
19217524-4	2009	[(90)Y]DOTA-complex-conjugated bisphosphonate ([(90)Y]DOTA-HBP) was prepared by coordination with (90)Y, and its biodistribution was studied in comparison to [(90)Y]citrate.	Citric Acid	165-172	heme binding protein 1	Homo sapiens	59-62
19177596-3	2009	ATP-citrate lyase (ACL) is a lipogenic enzyme that catalyzes the critical reaction linking cellular glucose catabolism and lipogenesis, converting cytosolic citrate to acetyl-coenzyme A (CoA).	Citric Acid	4-11	ATP citrate lyase	Mus musculus	19-22
19513421-2	2009	The effects of oxidized fibrinogen preparations on the clot formation by citrate-treated donor plasma were evaluated by the thrombin time test.	Citric Acid	73-80	fibrinogen beta chain	Homo sapiens	24-34
19513421-2	2009	The effects of oxidized fibrinogen preparations on the clot formation by citrate-treated donor plasma were evaluated by the thrombin time test.	Citric Acid	73-80	coagulation factor II, thrombin	Homo sapiens	124-132
18826429-6	2009	The AtALMT1 AtMATE double mutant lacked both Al-activated root malate and citrate exudation and showed greater Al sensitivity than the AtALMT1 mutant.	Citric Acid	74-81	aluminum-activated malate transporter 1	Arabidopsis thaliana	4-11
18550276-0	2009	Adsorption of Pb(II) and Pb(II)-citric acid on sawdust activated carbon: Kinetic and equilibrium isotherm studies.	Citric Acid	32-43	submaxillary gland androgen regulated protein 3B	Homo sapiens	25-31
18550276-1	2009	The removal of Pb(II) and Pb(II)-citric acid (Pb(II)-CA) from aqueous solutions by sawdust activated carbon (SDAC) was investigated.	Citric Acid	33-44	submaxillary gland androgen regulated protein 3B	Homo sapiens	26-32
18550276-1	2009	The removal of Pb(II) and Pb(II)-citric acid (Pb(II)-CA) from aqueous solutions by sawdust activated carbon (SDAC) was investigated.	Citric Acid	33-44	submaxillary gland androgen regulated protein 3B	Homo sapiens	26-32
20131677-12	2009	CONCLUSION: The utility of NaF, whether delivered from simple solution or toothpaste, to reduce citric acid-mediated surface roughening and bulk tissue loss has been clearly demonstrated.	Citric Acid	96-107	C-X-C motif chemokine ligand 8	Homo sapiens	27-30
18945875-5	2009	Organic and amino acid profiles of starved PPARalpha(-/-) mice suggested compromised citric acid cycle flux, enhanced urea cycle activity, and increased amino acid catabolism.	Citric Acid	85-96	peroxisome proliferator activated receptor alpha	Mus musculus	43-52
19053530-8	2009	A 50 mM citrate additive was tested successfully for UPLC-MS analysis of a commercial four-component phosphopeptide mixture, a tryptic beta-casein digest, and several digests of the 140 kDa protein SETDB1.	Citric Acid	8-15	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	198-204
18825335-8	2009	Recent studies with newly developed high-affinity and selective TRPV1 antagonists have revealed that TRPV1 inhibition reduces cough induced by citric acid or antigen challenge.	Citric Acid	143-154	transient receptor potential cation channel subfamily V member 1	Homo sapiens	64-69
18825335-8	2009	Recent studies with newly developed high-affinity and selective TRPV1 antagonists have revealed that TRPV1 inhibition reduces cough induced by citric acid or antigen challenge.	Citric Acid	143-154	transient receptor potential cation channel subfamily V member 1	Homo sapiens	101-106
18690549-1	2009	BACKGROUND: Rat dicarboxylate transporter (SDCT1), expressed in renal tubular epithelial cells, plays a key role in regulating blood and urinary citrate level by reabsorbing citrate from the lumen.	Citric Acid	145-152	solute carrier family 13 member 2L homeolog	Xenopus laevis	43-48
18690549-1	2009	BACKGROUND: Rat dicarboxylate transporter (SDCT1), expressed in renal tubular epithelial cells, plays a key role in regulating blood and urinary citrate level by reabsorbing citrate from the lumen.	Citric Acid	174-181	solute carrier family 13 member 2L homeolog	Xenopus laevis	43-48
18690549-12	2009	CONCLUSION: Generation of a high-specificity immunoglobulin G antibody against SDCT1 by genetic immunization has provided an important tool for the study of citrate transport.	Citric Acid	157-164	solute carrier family 13 member 2L homeolog	Xenopus laevis	79-84
19923105-5	2009	Mean values for citrate- and EDTA-treated plasma were most different for PT, PTT, factors V and VIII, and proteins C and S. Sodium tetraphenylborate testing correctly classified 100% of citratetreated and EDTA-treated samples.	Citric Acid	16-23	cytochrome c oxidase subunit 8A	Homo sapiens	96-100
20030444-4	2009	We hypothesized that increased levels of bradykinin could be responsible for the decrease in citric acid cough threshold on exposure to altitude and a possible etiologic factor in altitude-related cough.	Citric Acid	93-104	kininogen 1	Homo sapiens	41-51
18663378-0	2008	Apaf-1-deficient fog mouse cell apoptosis involves hypo-polarization of the mitochondrial inner membrane, ATP depletion and citrate accumulation.	Citric Acid	124-131	apoptotic peptidase activating factor 1	Mus musculus	0-6
19367869-2	2008	In this paper, we describe the great enhancement of red upconversion emission (4F9/2 --&gt; I15/2 transition of Er3+ ion) in NaYF4:Yb3+, Er3+ nanocrystals at low doping level, which is ascribed to the effectiveness of the multiphonon relaxation process due to the existence of citrate as a chelator and cross relaxation between Er3+ ions.	Citric Acid	277-284	CD82 molecule	Homo sapiens	79-84
18774285-6	2008	By mimicking the complete citric acid cycle on a carbon electrode, power density was increased 8.71-fold compared to a single enzyme (alcohol dehydrogenase)-based ethanol/air biofuel cell.	Citric Acid	26-37	aldo-keto reductase family 1 member A1	Homo sapiens	134-155
18663378-0	2008	Apaf-1-deficient fog mouse cell apoptosis involves hypo-polarization of the mitochondrial inner membrane, ATP depletion and citrate accumulation.	Citric Acid	124-131	zinc finger protein, multitype 1	Mus musculus	17-20
18979361-5	2008	Citrate resulted in significantly reduced collagen or TRAP-induced IPA and ATP release when measured 32 h and 48 h after blood collection.	Citric Acid	0-7	TRAP	Homo sapiens	54-58
18984166-4	2008	From one such prediction, we showed that the Gpr91 ligand succinate can regulate lipolysis in white adipose tissue, suggesting that signaling by this citric acid cycle intermediate may regulate energy homeostasis.	Citric Acid	150-161	succinate receptor 1	Mus musculus	45-50
19132246-4	2008	In the classic prothrombin time (PT) test, citrate plasma is mixed with thromboplastin and an excess of calcium ions.	Citric Acid	43-50	coagulation factor II, thrombin	Homo sapiens	15-26
19019213-4	2008	The cough reflex sensitivities were defined as the lowest concentration of citric acid that elicited two or more coughs (C2) and five or more coughs (C5).	Citric Acid	75-86	complement C2	Homo sapiens	121-123
19019213-4	2008	The cough reflex sensitivities were defined as the lowest concentration of citric acid that elicited two or more coughs (C2) and five or more coughs (C5).	Citric Acid	75-86	complement C5	Homo sapiens	150-152
18854275-4	2008	The correlation coefficients (95% confidence intervals [CIs]) between levels in EDTA- and citrate-anticoagulated plasma samples were 0.893 (0.806-0.943) for FVII antigen (ag), 0.930 (0.870-0.962) for FVIIIag, 0.990 (0.981-0.995) for vWFag, and 0.949 (0.906-0.973) for vWF activity.	Citric Acid	90-97	von Willebrand factor	Homo sapiens	233-236
18697738-7	2008	Consistent with a block at PC, the most PC-deficient cells showed a metabolic crossover point at PC with increased basal and/or glucose-stimulated pyruvate plus lactate and decreased malate and citrate.	Citric Acid	194-201	pyruvate carboxylase	Homo sapiens	40-42
18697738-7	2008	Consistent with a block at PC, the most PC-deficient cells showed a metabolic crossover point at PC with increased basal and/or glucose-stimulated pyruvate plus lactate and decreased malate and citrate.	Citric Acid	194-201	pyruvate carboxylase	Homo sapiens	40-42
18697738-8	2008	In addition, in BCH plus glutamine-stimulated PC knockdown cells, pyruvate plus lactate was increased, whereas citrate was severely decreased, and malate and aspartate were slightly decreased.	Citric Acid	111-118	NK2 homeobox 1	Homo sapiens	16-19
18697738-8	2008	In addition, in BCH plus glutamine-stimulated PC knockdown cells, pyruvate plus lactate was increased, whereas citrate was severely decreased, and malate and aspartate were slightly decreased.	Citric Acid	111-118	pyruvate carboxylase	Homo sapiens	46-48
18680753-6	2008	Furthermore, Sirt3 deacetylates and activates isocitrate dehydrogenase 2, an enzyme that promotes regeneration of antioxidants and catalyzes a key regulation point of the citric acid cycle.	Citric Acid	171-182	sirtuin 3	Homo sapiens	13-18
18558494-7	2008	After washing out unbound proteins, column-captured fibrinogen was specifically eluted down with a citrate buffer solution (50mM, pH 5.6).	Citric Acid	99-106	fibrinogen beta chain	Homo sapiens	52-62
18806796-2	2008	Affected family members were homozygous for loss-of-function mutations in IDH3B, encoding the beta-subunit of NAD-specific isocitrate dehydrogenase (NAD-IDH, or IDH3), which is believed to catalyze the oxidation of isocitrate to alpha-ketoglutarate in the citric acid cycle.	Citric Acid	256-267	isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta	Homo sapiens	74-79
18553042-3	2008	We therefore tested the hypothesis that calcium as citrate is more effective than calcium as carbonate in suppressing parathyroid hormone (PTH) and C-terminal telopeptide.	Citric Acid	51-58	parathyroid hormone	Homo sapiens	118-137
18553042-3	2008	We therefore tested the hypothesis that calcium as citrate is more effective than calcium as carbonate in suppressing parathyroid hormone (PTH) and C-terminal telopeptide.	Citric Acid	51-58	parathyroid hormone	Homo sapiens	139-142
18239072-7	2008	It is also shown that the A-TIM active site can bind compounds which do not bind to wild-type TIM and which are completely different from the normal TIM substrate, like a citrate molecule.	Citric Acid	171-178	triosephosphate isomerase 1	Homo sapiens	28-31
18515854-5	2008	One of them, the product of the gene CG6782, shows a fairly close sequence homology to the known sequence of the rat mitochondrial citrate carrier.	Citric Acid	131-138	scheggia	Drosophila melanogaster	37-43
18455495-10	2008	Taken together, these data suggest that recombinant human ACC1 and ACC2 are differentially activated by citrate, most likely through conformational changes leading to aggregation, with ACC2 being more sensitive to this activator.	Citric Acid	104-111	acetyl-CoA carboxylase alpha	Homo sapiens	58-62
18455495-10	2008	Taken together, these data suggest that recombinant human ACC1 and ACC2 are differentially activated by citrate, most likely through conformational changes leading to aggregation, with ACC2 being more sensitive to this activator.	Citric Acid	104-111	acetyl-CoA carboxylase beta	Homo sapiens	67-71
18455495-10	2008	Taken together, these data suggest that recombinant human ACC1 and ACC2 are differentially activated by citrate, most likely through conformational changes leading to aggregation, with ACC2 being more sensitive to this activator.	Citric Acid	104-111	acetyl-CoA carboxylase beta	Homo sapiens	185-189
18469022-0	2008	Intracerebroventricular injection of citrate inhibits hypothalamic AMPK and modulates feeding behavior and peripheral insulin signaling.	Citric Acid	37-44	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	67-71
18469022-1	2008	We hypothesized that citrate might modulate the AMP-activated protein kinase/acetyl-CoA carboxylase (AMPK)/(ACC) pathway and participate in neuronal feeding control and glucose homeostasis.	Citric Acid	21-28	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	48-99
18469022-1	2008	We hypothesized that citrate might modulate the AMP-activated protein kinase/acetyl-CoA carboxylase (AMPK)/(ACC) pathway and participate in neuronal feeding control and glucose homeostasis.	Citric Acid	21-28	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	101-105
18469022-3	2008	Intracerebroventricular (ICV) injection of citrate diminished the phosphorylation of hypothalamic AMPK/ACC, increased the expression of anorexigenic neuropeptide (pro-opiomelanocortin and corticotropin-releasing hormone), elevated the level of malonyl-CoA in the hypothalamus, and reduced food intake.	Citric Acid	43-50	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	98-102
18469022-3	2008	Intracerebroventricular (ICV) injection of citrate diminished the phosphorylation of hypothalamic AMPK/ACC, increased the expression of anorexigenic neuropeptide (pro-opiomelanocortin and corticotropin-releasing hormone), elevated the level of malonyl-CoA in the hypothalamus, and reduced food intake.	Citric Acid	43-50	pyroglutamylated RFamide peptide	Rattus norvegicus	149-161
18469022-3	2008	Intracerebroventricular (ICV) injection of citrate diminished the phosphorylation of hypothalamic AMPK/ACC, increased the expression of anorexigenic neuropeptide (pro-opiomelanocortin and corticotropin-releasing hormone), elevated the level of malonyl-CoA in the hypothalamus, and reduced food intake.	Citric Acid	43-50	proopiomelanocortin	Rattus norvegicus	163-183
17351819-8	2008	GhAOX1 was also found to be induced by a variety of stresses stimulation including cold, citrate, SA, KCN and antimycin A in cotton.	Citric Acid	89-96	ubiquinol oxidase 2, mitochondrial-like	Gossypium hirsutum	0-6
18625772-6	2008	Determination of the 1.23-A structure of a KPC-2 mutant in which the five C-ter residues were deleted revealed that the catalytic site was filled by a citrate molecule.	Citric Acid	151-158	KPC-2	Escherichia coli	43-48
18588337-6	2008	The addition of sodium fluoride to citric acid solutions leads to formation of surface CaF2 and considerably reduces the changes in the apatite P-O-Ca framework.	Citric Acid	35-46	CCR4-NOT transcription complex subunit 8	Homo sapiens	87-91
18455495-2	2008	In the current study, we found that citrate activated recombinant human ACC2 by more than approximately 1000-fold, but activated recombinant human ACC1 only by approximately 4-fold.	Citric Acid	36-43	acetyl-CoA carboxylase beta	Homo sapiens	72-76
18455495-2	2008	In the current study, we found that citrate activated recombinant human ACC2 by more than approximately 1000-fold, but activated recombinant human ACC1 only by approximately 4-fold.	Citric Acid	36-43	acetyl-CoA carboxylase alpha	Homo sapiens	147-151
18455495-4	2008	Citrate activates ACCs at lower concentrations and inhibits at higher concentrations with apparent K(d) values of 0.8+/-0.3 and 3.4+/-0.6 mM, and apparent K(i) values of 20+/-8 and 38 +/-8 mM for ACC1 and ACC2, respectively.	Citric Acid	0-7	acetyl-CoA carboxylase alpha	Homo sapiens	196-200
18455495-4	2008	Citrate activates ACCs at lower concentrations and inhibits at higher concentrations with apparent K(d) values of 0.8+/-0.3 and 3.4+/-0.6 mM, and apparent K(i) values of 20+/-8 and 38 +/-8 mM for ACC1 and ACC2, respectively.	Citric Acid	0-7	acetyl-CoA carboxylase beta	Homo sapiens	205-209
18455495-5	2008	In the absence of added citrate, both ACC1 and ACC2 were inactivated by avidin rapidly and completely.	Citric Acid	24-31	acetyl-CoA carboxylase alpha	Homo sapiens	38-42
18455495-5	2008	In the absence of added citrate, both ACC1 and ACC2 were inactivated by avidin rapidly and completely.	Citric Acid	24-31	acetyl-CoA carboxylase beta	Homo sapiens	47-51
18455495-6	2008	Addition of 10 mM citrate protected ACC2 from avidin inactivation; however, protection by citrate was less pronounced for ACC1.	Citric Acid	18-25	acetyl-CoA carboxylase beta	Homo sapiens	36-40
18455495-6	2008	Addition of 10 mM citrate protected ACC2 from avidin inactivation; however, protection by citrate was less pronounced for ACC1.	Citric Acid	90-97	acetyl-CoA carboxylase alpha	Homo sapiens	122-126
18469022-3	2008	Intracerebroventricular (ICV) injection of citrate diminished the phosphorylation of hypothalamic AMPK/ACC, increased the expression of anorexigenic neuropeptide (pro-opiomelanocortin and corticotropin-releasing hormone), elevated the level of malonyl-CoA in the hypothalamus, and reduced food intake.	Citric Acid	43-50	corticotropin releasing hormone	Rattus norvegicus	188-219
18397368-7	2008	A modest increase in citric acid taste sensitivity in these knockout mice suggests GLP-1 signaling may modulate sour taste, as well.	Citric Acid	21-32	glucagon	Mus musculus	83-88
18459103-7	2008	In old TRAMP mice with well-defined malignancy, reduced tumor levels of citrate (49%), choline (33%), PC (57%), GPC (66%), and glycerophosphoinositol (61%) were observed relative to normal prostate (P &lt; 0.05).	Citric Acid	72-79	tumor necrosis factor receptor superfamily, member 25	Mus musculus	7-12
18585204-2	2008	The immunoreaction between AuRhCG and hCG take place to form hCG-AuRhCG immunocomplex in pH 5.0 citric acid-Na(2)HPO(4) buffer solution.	Citric Acid	96-107	chorionic gonadotropin subunit beta 5	Homo sapiens	30-33
18585204-2	2008	The immunoreaction between AuRhCG and hCG take place to form hCG-AuRhCG immunocomplex in pH 5.0 citric acid-Na(2)HPO(4) buffer solution.	Citric Acid	96-107	chorionic gonadotropin subunit beta 5	Homo sapiens	38-41
18509013-8	2008	MPO concentrations were consistently higher in samples collected in serum and heparin plasma tubes than in samples in EDTA or citrate tubes.	Citric Acid	126-133	myeloperoxidase	Homo sapiens	0-3
18022670-0	2008	Influence of clay minerals on the reduction of Cr6+ by citric acid.	Citric Acid	55-66	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	47-50
18022670-1	2008	The influence of clay minerals on the reduction of Cr6+ by citric acid was investigated at pH values 4.0, 4.5 and 5.0 at 25 degrees C. The results indicate that montmorillonite and illite greatly accelerate the reduction reactions at pH 4.0 and 4.5, but their effects are dramatically reduced at pH 5.0.	Citric Acid	59-70	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	51-54
18022670-5	2008	Thus, the formation of complexes between Mn(2+) and citric acid could be a prerequisite for the acceleration of the reductions of Cr6+ by clay minerals.	Citric Acid	52-63	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	130-133
18162426-7	2008	This strain gave a maximum yield of 0.9g citrate per g glucose and a maximum specific productivity of 0.025g citrate per g DW per h. Overexpression of mdh2 alone resulted in an increased citrate production rate only in the initial phase of the fermentations compared with the other transformants and the wild type.	Citric Acid	41-48	malate dehydrogenase MDH2	Saccharomyces cerevisiae S288C	151-155
18162426-7	2008	This strain gave a maximum yield of 0.9g citrate per g glucose and a maximum specific productivity of 0.025g citrate per g DW per h. Overexpression of mdh2 alone resulted in an increased citrate production rate only in the initial phase of the fermentations compared with the other transformants and the wild type.	Citric Acid	109-116	malate dehydrogenase MDH2	Saccharomyces cerevisiae S288C	151-155
18162426-7	2008	This strain gave a maximum yield of 0.9g citrate per g glucose and a maximum specific productivity of 0.025g citrate per g DW per h. Overexpression of mdh2 alone resulted in an increased citrate production rate only in the initial phase of the fermentations compared with the other transformants and the wild type.	Citric Acid	109-116	malate dehydrogenase MDH2	Saccharomyces cerevisiae S288C	151-155
17847084-0	2008	Structure of aspartate racemase complexed with a dual substrate analogue, citric acid, and implications for the reaction mechanism.	Citric Acid	74-85	aspartate/glutamate racemase family protein	Pyrococcus horikoshii OT3	13-31
17847084-11	2008	Based on the PhAspR-Cit complex structure, the reaction mechanism of aspartate racemase was elucidated.	Citric Acid	20-23	aspartate/glutamate racemase family protein	Pyrococcus horikoshii OT3	69-87
18160486-9	2008	In line with this, citrate was increased by beta-hydroxybutyrate plus MMS in INS-1 cells and by beta-hydroxybutyrate plus succinate in mitochondria.	Citric Acid	19-26	insulin 1	Rattus norvegicus	77-82
17991444-0	2008	Oxidative stress in hypercholesterolemic LDL (low-density lipoprotein) receptor knockout mice is associated with low content of mitochondrial NADP-linked substrates and is partially reversed by citrate replacement.	Citric Acid	194-201	low density lipoprotein receptor	Mus musculus	46-79
17991444-8	2008	In conclusion, the data demonstrate that the mitochondrial oxidative stress in hypercholesterolemic LDL receptor knockout mice is the result of a low content of mitochondrial NADPH-linked substrates in the intact animal that can be, at least in part, replenished by oral administration of citrate.	Citric Acid	289-296	low density lipoprotein receptor	Mus musculus	100-112
18082127-5	2008	Increasing the amounts of nonsoluble silica and soluble silicate added to citrate and empty tubes prior to blood collection resulted in increasing levels of MMP-9 relative to citrate plasma and serum.	Citric Acid	74-81	matrix metallopeptidase 9	Homo sapiens	157-162
18227254-5	2008	Strains lacking CTN1 or CTN2 were unable to grow on ethanol or acetate as sole carbon source; additionally, citrate was utilized poorly (Deltactn2) or not at all (Deltactn1) and the Deltactn2 mutant failed to grow on fatty acids as well.	Citric Acid	108-115	Ras family guanine nucleotide exchange factor CDC25	Saccharomyces cerevisiae S288C	16-20
18161988-1	2008	The Na+/dicarboxylate cotransporter (NaDC1) is involved in the absorption of citric acid cycle intermediates from the lumen of the renal proximal tubule and small intestine.	Citric Acid	77-88	solute carrier family 13 member 2	Oryctolagus cuniculus	37-42
18161988-2	2008	The NaDC1 orthologues from human (h) and rabbit (rb) exhibit differences in citrate and cation transport properties.	Citric Acid	76-83	solute carrier family 13 member 2	Homo sapiens	4-9
18161988-3	2008	The citrate Km and sodium KNa values are much larger in human than rabbit NaDC1.	Citric Acid	4-11	solute carrier family 13 member 2	Oryctolagus cuniculus	74-79
17954369-1	2007	BACKGROUND: Recent evidence suggests that succinate, long known as an intermediate in the citric acid cycle, may also have a role as a signaling molecule through GPR91 and that activation of this receptor results in blood pressure (BP) elevation via the renin-angiotensin system.	Citric Acid	90-101	succinate receptor 1	Homo sapiens	162-167
17936256-4	2008	RESULTS: In citric acid-Na(2)HPO(4) buffer solution and in the presence of polyethylene glycol (PEG)6000, the immunoreaction between hCG and nanogold-labeled anti-hCG took place, the immunonanogold-complex was formed and deposited.	Citric Acid	12-23	chorionic gonadotropin subunit beta 5	Homo sapiens	133-136
18605954-0	2008	Can both EDTA and citrate plasma samples be used in measurements of fibrinogen and C-reactive protein concentrations?	Citric Acid	18-25	fibrinogen beta chain	Homo sapiens	68-78
18605954-0	2008	Can both EDTA and citrate plasma samples be used in measurements of fibrinogen and C-reactive protein concentrations?	Citric Acid	18-25	C-reactive protein	Homo sapiens	83-101
18605954-4	2008	Fibrinogen was also measured in citrate plasma using a clotting method.	Citric Acid	32-39	fibrinogen beta chain	Homo sapiens	0-10
18605954-5	2008	RESULTS: In approximately one-third of the samples, the fibrinogen concentration measured by immunoassay was higher in citrate plasma than in EDTA plasma, in spite of the dilution by citrate.	Citric Acid	119-126	fibrinogen beta chain	Homo sapiens	56-66
18605954-6	2008	The immunoassay results of fibrinogen concentration measurements in EDTA and citrate plasma differed significantly and also differed from those of functionally measured fibrinogen concentrations.	Citric Acid	77-84	fibrinogen beta chain	Homo sapiens	27-37
18605954-11	2008	Fibrinogen concentrations should preferably be measured functionally in citrate plasma.	Citric Acid	72-79	fibrinogen beta chain	Homo sapiens	0-10
17951087-3	2008	The number of citric-acid-induced coughs in sensitized guinea pigs was dose-dependently and significantly reduced to the level in non-sensitized guinea pigs when animals were pretreated with fexofenadine, a selective histamine H1 receptor antagonist, 60min before citric acid inhalation.	Citric Acid	14-25	histamine H1 receptor	Cavia porcellus	217-238
18224564-8	2008	No significant correlations were found between TIMP-1 content in the tumour extracts and in blood.However, EDTA and citrate plasma TIMP-1 levels (r=0.75; p &lt;0.0001) as well as EDTA plasma and serum TIMP-1 levels (r= .064; p&lt;0.0001) were highly correlated.	Citric Acid	116-123	TIMP metallopeptidase inhibitor 1	Homo sapiens	131-137
18224564-8	2008	No significant correlations were found between TIMP-1 content in the tumour extracts and in blood.However, EDTA and citrate plasma TIMP-1 levels (r=0.75; p &lt;0.0001) as well as EDTA plasma and serum TIMP-1 levels (r= .064; p&lt;0.0001) were highly correlated.	Citric Acid	116-123	TIMP metallopeptidase inhibitor 1	Homo sapiens	131-137
18154688-0	2007	Inhibition of citric acid- and capsaicin-induced cough by novel TRPV-1 antagonist, V112220, in guinea-pig.	Citric Acid	14-25	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	64-70
18181122-1	2008	An indirect magnetic resonance imaging (MRI) method has been developed to determine in a noninvasive manner the distribution of paramagnetic Co2+ complexes inside Co/Al2O3 catalyst extrudates after impregnation with Co2+/citrate solutions of different pH and citrate concentrations.	Citric Acid	221-228	complement C2	Homo sapiens	141-144
18181122-1	2008	An indirect magnetic resonance imaging (MRI) method has been developed to determine in a noninvasive manner the distribution of paramagnetic Co2+ complexes inside Co/Al2O3 catalyst extrudates after impregnation with Co2+/citrate solutions of different pH and citrate concentrations.	Citric Acid	259-266	complement C2	Homo sapiens	141-144
18181122-5	2008	Complexation of Co2+ by citrate was found to lead to a stronger interaction of Co with the support surface and formation of an eggshell distribution of Co2+ complexes after impregnation.	Citric Acid	24-31	complement C2	Homo sapiens	16-19
18181122-5	2008	Complexation of Co2+ by citrate was found to lead to a stronger interaction of Co with the support surface and formation of an eggshell distribution of Co2+ complexes after impregnation.	Citric Acid	24-31	complement C2	Homo sapiens	152-155
18181122-6	2008	By addition of free citrate and by changing the pH of the impregnation solution, it was possible to obtain the rather uncommon egg-yolk and egg-white distributions of Co2+ inside the extrudates after impregnation.	Citric Acid	20-27	complement C2	Homo sapiens	167-170
17960358-12	2008	The study supports the view that amplification results from the intramitochondrial production of citrate by citrate synthase and from the associated export of citrate into the cytosol.	Citric Acid	97-104	citrate synthase	Mus musculus	108-124
17953660-7	2007	Instead, iron is probably released from transferrin on the abluminal surface of these cells by the action of citrate and ATP that are released by astrocytes, which form a very close relationship with BCECs.	Citric Acid	109-116	transferrin	Homo sapiens	40-51
17953660-8	2007	Complexes of iron with citrate and ATP can then circulate in brain extracellular fluid and may be taken up in these low-molecular weight forms by all types of brain cells or be bound by transferrin and taken up by cells which express transferrin receptors.	Citric Acid	23-30	transferrin	Homo sapiens	234-245
17945281-11	2007	CONCLUSIONS: The prostacyclin receptor antagonist RO3244019 decreased bladder contraction frequency and increased micturition threshold in the anesthetized isovolumetric bladder contraction and Refill models, respectively, and increased the micturition voiding interval in the conscious citric acid induced detrusor overactivity model.	Citric Acid	287-298	prostaglandin I2 receptor	Rattus norvegicus	17-38
17923106-3	2007	There are evidences that some positive and negative modulators of PFK, such as ADP and citrate, may interfere with the enzyme oligomeric structure shifting the tetramer-dimer equilibrium towards opposite orientations, where the negative modulators favor the dissociation of tetramers into dimers and vice versa.	Citric Acid	87-94	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	66-69
17904541-3	2007	RESULTS: : Active MMP-2 and MMP-9 mean concentrations were similar in serum and in plasma-citrate, higher in plasma EDTA than in serum, in plasma-heparin and in plasma-citrate, and lower in plasma-heparin than in serum and plasma-citrate.	Citric Acid	90-97	matrix metallopeptidase 2	Homo sapiens	18-23
17954502-0	2007	Silicate increases the release of MMP-9 forms in peripheral blood: why gelatin zymography differs significantly in citrate plasma and serum obtained with or without clot activators.	Citric Acid	115-122	matrix metallopeptidase 9	Homo sapiens	34-39
17904541-3	2007	RESULTS: : Active MMP-2 and MMP-9 mean concentrations were similar in serum and in plasma-citrate, higher in plasma EDTA than in serum, in plasma-heparin and in plasma-citrate, and lower in plasma-heparin than in serum and plasma-citrate.	Citric Acid	90-97	matrix metallopeptidase 9	Homo sapiens	28-33
17867930-9	2007	SKI-1/S1P inhibition was observed to affect a number of other metabolic pathways, including glycolysis and citric acid cycle.	Citric Acid	107-118	membrane bound transcription factor peptidase, site 1	Homo sapiens	0-5
17867930-9	2007	SKI-1/S1P inhibition was observed to affect a number of other metabolic pathways, including glycolysis and citric acid cycle.	Citric Acid	107-118	membrane bound transcription factor peptidase, site 1	Homo sapiens	6-9
17715401-1	2007	The Na(+)/dicarboxylate cotransporter NaDC1 absorbs citric acid cycle intermediates from the lumen of the small intestine and kidney proximal tubule.	Citric Acid	52-63	solute carrier family 13 member 2	Homo sapiens	38-43
18299720-4	2007	Before the physical load, salivary chromogranin A, measured as a physiological stress marker, was lower in the group given citric acid than in the group given placebo.	Citric Acid	123-134	chromogranin A	Homo sapiens	35-49
17976259-0	2007	Citric acid as a solid-state plasticizer for Eudragit RS PO.	Citric Acid	0-11	R-spondin 1	Homo sapiens	54-59
17976259-2	2007	The purpose of this study was to determine the suitability of citric acid (CA) as a solid plasticizer for the preparation of Eudragit RS PO extended-release matrix systems by a melt extrusion technique.	Citric Acid	62-73	R-spondin 1	Homo sapiens	134-139
17505104-1	2007	The crystal structure of human aldose reductase in complex with citrate has been determined to a resolution of 0.82 A.	Citric Acid	64-71	aldo-keto reductase family 1 member B	Homo sapiens	31-47
17724028-4	2007	Studies of 12 relevant enzymes in rat and human pancreatic islets and INS-1 832/13 cells showed the feasibility of at least two redundant pathways, one involving acetoacetate and the other citrate, for the synthesis SC-CoAs from secretagogue carbon in mitochondria and the transfer of their acyl groups to the cytosol where the acyl groups are converted to SC-CoAs.	Citric Acid	189-196	insulin 1	Rattus norvegicus	70-75
17570335-1	2007	In this study, the product of the CIT3 gene has been identified as a dual specificity mitochondrial citrate and methylcitrate synthase and that of the CIT1 gene as a specific citrate synthase.	Citric Acid	100-107	citrate (Si)-synthase CIT3	Saccharomyces cerevisiae S288C	34-38
17676935-1	2007	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) of the pathogenic protozoa Entamoeba histolytica (Eh) is a major glycolytic enzyme and an attractive drug target since this parasite lacks a functional citric acid cycle and is dependent solely on glycolysis for its energy requirements.	Citric Acid	201-212	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	42-47
17525933-0	2007	Effect of metabolic inhibitors on ATP and citrate content in PC3 prostate cancer cells.	Citric Acid	42-49	chromobox 8	Homo sapiens	61-64
17525933-11	2007	CONCLUSION: PC3 cells can support ATP production when m-aconitase is inhibited by using glycolysis or oxidation of substrate (e.g., glutamine) entering the TCA cycle distal to citrate.	Citric Acid	176-183	chromobox 8	Homo sapiens	12-15
17551710-9	2007	Furthermore, HvMATE expression in the F(2:3) families tested, including all the informative recombinant lines identified between HvGABP and ABG715 was significantly correlated with Al tolerance and Al-activated citrate efflux.	Citric Acid	211-218	HvMATE	Hordeum vulgare	13-19
17447058-2	2007	Here we report the production of citric acid (CA) in a fed-batch cultivation process on sucrose using the recombinant Y. lipolytica strain H222-S4(p67ICL1) T5, harbouring the invertase encoding ScSUC2 gene of Saccharomyces cerevisiae under the inducible XPR2 promoter control and multiple ICL1 copies (10-15).	Citric Acid	33-44	isocitrate lyase 1	Saccharomyces cerevisiae S288C	150-154
17097337-3	2007	At pH 3.8 Na(2)HPO(4)-citric acid buffer solution, the RLS intensities of PMAA-BSA (HSA) system were greatly enhanced.	Citric Acid	22-33	albumin	Homo sapiens	79-82
17446700-7	2007	Median serum PTH was higher (30.0 pmol/l vs. 6.5 pmol/l, p = 0.003) in the citrate group.	Citric Acid	75-82	parathyroid hormone	Homo sapiens	13-16
17408294-11	2007	FB aggregated and redissolved in the presence of the citrate and after the citrate was removed.	Citric Acid	53-60	fibrinogen beta chain	Homo sapiens	0-2
17408294-11	2007	FB aggregated and redissolved in the presence of the citrate and after the citrate was removed.	Citric Acid	75-82	fibrinogen beta chain	Homo sapiens	0-2
17351051-0	2007	The FRD3-mediated efflux of citrate into the root vasculature is necessary for efficient iron translocation.	Citric Acid	28-35	MATE efflux family protein	Arabidopsis thaliana	4-8
17351051-8	2007	Xylem exudate from frd3 plants contains significantly less citrate and iron than the exudate from wild-type plants.	Citric Acid	59-66	MATE efflux family protein	Arabidopsis thaliana	19-23
17351051-9	2007	Additionally, supplementation of growth media with citrate rescues the frd3 phenotypes.	Citric Acid	51-58	MATE efflux family protein	Arabidopsis thaliana	71-75
17351051-11	2007	Consistent with this result, approximately 3 times more citrate was detected in root exudate from plants ectopically expressing FRD3-GFP.	Citric Acid	56-63	MATE efflux family protein	Arabidopsis thaliana	128-132
17351051-12	2007	Finally, heterologous studies in Xenopus laevis oocytes reveal that FRD3 mediates the transport of citrate.	Citric Acid	99-106	MATE efflux family protein	Arabidopsis thaliana	68-72
17351051-13	2007	These results all strongly support the hypothesis that FRD3 effluxes citrate into the root vasculature, a process important for the translocation of iron to the leaves, as well as confirm previous reports suggesting that iron moves through the xylem as a ferric-citrate complex.	Citric Acid	69-76	MATE efflux family protein	Arabidopsis thaliana	55-59
17409499-5	2007	The results clearly showed a linear relationship between urinary pH and chemical shift of citrate in 1H-NMR spectra both in mice and rats.	Citric Acid	90-97	inversion, Chr X, Harwell 1	Mus musculus	98-103
17182618-4	2007	Oxaloacetate was an additional inhibitor of all three HIF-P4Hs with K(i) values of 400-1000 microM and citrate of HIF-P4H-3, citrate being the most effective inhibitor of FIH with a K(i) of 110 microM.	Citric Acid	103-110	egl-9 family hypoxia inducible factor 3	Homo sapiens	114-123
16973915-1	2007	In this article, we report on the expression and function of a Na(+)-coupled transporter for citrate, NaCT, in human and rat liver cell lines and in primary hepatocytes from the rat liver.	Citric Acid	93-100	solute carrier family 13 member 5	Homo sapiens	102-106
16973915-3	2007	Citrate uptake in human liver cell lines HepG2 and Huh-7 was obligatorily dependent on Na+.	Citric Acid	0-7	MIR7-3 host gene	Homo sapiens	51-56
17205209-3	2007	Assembly and disassembly of Fe-S clusters is a key process not only in regulating the enzymatic activity of mitochondrial aconitase in the citric acid cycle, but also in controlling the iron sensing and RNA binding activities of cytosolic aconitase (also known as iron regulatory protein IRP1).	Citric Acid	139-150	aconitase 2	Homo sapiens	108-131
17205209-3	2007	Assembly and disassembly of Fe-S clusters is a key process not only in regulating the enzymatic activity of mitochondrial aconitase in the citric acid cycle, but also in controlling the iron sensing and RNA binding activities of cytosolic aconitase (also known as iron regulatory protein IRP1).	Citric Acid	139-150	aconitase 1	Homo sapiens	288-292
17400183-3	2007	With citrate, a well-known kosmotrope to enhance the monomer-dimer transition, caspase-4 was activated approximately 40 times that was comparable with that of caspase-9 ( approximately 75-fold increments).	Citric Acid	5-12	caspase 4	Homo sapiens	79-88
17400183-3	2007	With citrate, a well-known kosmotrope to enhance the monomer-dimer transition, caspase-4 was activated approximately 40 times that was comparable with that of caspase-9 ( approximately 75-fold increments).	Citric Acid	5-12	caspase 9	Homo sapiens	159-168
17229526-4	2007	Fructose-2,6-bisphosphate (fru-2,6-P(2)) converted the saturation curves for fru-6-P to hyperbolic, activated PFKM synergistically with other positive effectors of the enzyme such as AMP and ADP, and counteracted ATP and citrate inhibition.	Citric Acid	221-228	phosphofructokinase, muscle	Homo sapiens	110-114
17443871-0	2007	On a hypothetical generational relationship between HCN and constituents of the reductive citric acid cycle.	Citric Acid	90-101	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	52-55
17443871-1	2007	Encouraged by observations made on the course of reactions the HCN-tetramer can undergo with acetaldehyde, I delineate a constitutional and potentially generational relationship between HCN and those constituents of the reductive citric acid cycle that are direct precursors of amino acids in contemporary metabolism.	Citric Acid	230-241	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	63-66
17443871-1	2007	Encouraged by observations made on the course of reactions the HCN-tetramer can undergo with acetaldehyde, I delineate a constitutional and potentially generational relationship between HCN and those constituents of the reductive citric acid cycle that are direct precursors of amino acids in contemporary metabolism.	Citric Acid	230-241	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	186-189
17319879-7	2007	The ICL enzyme activity in crude extracts from cultures of the PAO1 strain was induced by acetate, citronellol and leucine, and repressed by growth on glucose or citrate.	Citric Acid	162-169	isocitrate lyase	Pseudomonas aeruginosa PAO1	4-7
17470169-0	2007	Associations between renal sodium-citrate cotransporter (hNaDC-1) gene polymorphism and urinary citrate excretion in recurrent renal calcium stone formers and normal controls.	Citric Acid	34-41	solute carrier family 13 member 2	Homo sapiens	57-64
17470169-9	2007	CONCLUSION: These results suggest that the B allele of I550V polymorphism of hNaDC-1 may be associated with a reduction in urinary citrate excretion and contribute to hypocitraturia in recurrent renal stone formers.	Citric Acid	131-138	solute carrier family 13 member 2	Homo sapiens	77-84
17240345-6	2007	We found that chemerin 145-154 is C-terminally truncated in human citrate plasma by the cleavage of the penultimate dipeptidyl residue.	Citric Acid	66-73	retinoic acid receptor responder 2	Homo sapiens	14-22
17536314-1	2007	We describe a modification to the prescribed procedure for the Zymed Spot-Light HER2 chromogenic in situ hybridization kit (84-0146, Zymed Laboratories, San Francisco, CA) by substituting the heat pretreatment step with MW irradiation in citrate buffer 10 mmol/L at pH 6.0 at 98 degrees C for 10 minutes and repeating the procedure afterenzyme digestion with time and temperature controlled in the Mega T/ T oven (Milestone s.r.l., Sorisole, Italy).	Citric Acid	238-245	erb-b2 receptor tyrosine kinase 2	Homo sapiens	80-84
17279667-2	2007	From a direct comparison with its resonance Raman spectrum in solution, CYP2D6 appears to fully retain its native structure upon adsorption on coated hydrosol through electrostatic interaction, while a structural change in the active site is observed when uncoated citrate-reduced hydrosol is used.	Citric Acid	265-272	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	72-78
17446700-8	2007	CONCLUSION: With a relative low target-serum-iCa (0.8-0.9 mmol/l) citrate CVVH-treated patients had a negative daily calcium balance and a temporarily lower iCa level resulting in an enhanced PTH response in comparison to nadroparin.	Citric Acid	66-73	parathyroid hormone	Homo sapiens	192-195
17184967-10	2007	This study shows that a higher level of insulin resistance is associated with lower urinary citrate excretion, and that hypocitraturic patients show a greater insulin resistance than normocitraturic calcium stone formers.	Citric Acid	92-99	insulin	Homo sapiens	40-47
17184967-11	2007	This may be related to changes in citrate, Na(+)-K(+) and H(+) renal tubule transports, which have been described in insulin resistance.	Citric Acid	34-41	insulin	Homo sapiens	117-124
17184967-12	2007	In conclusion, insulin resistance may contribute to an increased risk of calcium stone formation by lowering urinary citrate excretion.	Citric Acid	117-124	insulin	Homo sapiens	15-22
17150202-4	2007	RESULTS: MMPs are released by platelets or leukocytes during platelet activation or sampling process, thus leading to artificially higher MMP-9 levels in serum compared with citrate, heparin, or EDTA plasma samples, independently of TBDC.	Citric Acid	174-181	matrix metallopeptidase 2	Homo sapiens	9-13
17150202-5	2007	Citrate and heparin plasma samples had the lowest Pro-MMP-9 and MMP-9 levels, which correlated with each other.	Citric Acid	0-7	matrix metallopeptidase 9	Homo sapiens	54-59
17150202-5	2007	Citrate and heparin plasma samples had the lowest Pro-MMP-9 and MMP-9 levels, which correlated with each other.	Citric Acid	0-7	matrix metallopeptidase 9	Homo sapiens	64-69
17150202-6	2007	Pro-MMP-9 levels in serum correlated with Pro-MMP-9 levels in EDTA or citrate plasma, but not with heparin plasma.	Citric Acid	70-77	matrix metallopeptidase 9	Homo sapiens	4-9
17150202-6	2007	Pro-MMP-9 levels in serum correlated with Pro-MMP-9 levels in EDTA or citrate plasma, but not with heparin plasma.	Citric Acid	70-77	matrix metallopeptidase 9	Homo sapiens	46-51
17150202-9	2007	CONCLUSIONS: These results suggest that the circulating levels of MMP-9 should be assessed in citrate or heparin plasma samples, but not in serum samples because of artificially higher MMP-9 levels in serum, independently of TBDC, and because they do not correlate with the MMP-9 levels in plasma samples.	Citric Acid	94-101	matrix metallopeptidase 9	Homo sapiens	66-71