PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 25101950-3 2014 A combination of the Ir complex and a (PNN)Fe pincer complex catalyzes the formation of linear alkylboronates selectively from internal olefins via sequential olefin isomerization-hydroboration. Alkenes 136-143 pinin, desmosome associated protein Homo sapiens 39-42 25101950-3 2014 A combination of the Ir complex and a (PNN)Fe pincer complex catalyzes the formation of linear alkylboronates selectively from internal olefins via sequential olefin isomerization-hydroboration. Alkenes 136-142 pinin, desmosome associated protein Homo sapiens 39-42 25125283-4 2014 7 a,b(syn,anti) were probed in olefin hydrogenations in the absence or presence of a hydrosilane/B(C6 F5 )3 mixture. Alkenes 31-37 synemin Homo sapiens 6-9 25125283-5 2014 The 7 a,b(syn,anti)/Et3 SiH/B(C6 F5 )3 co-catalytic systems were highly active in various olefin hydrogenations (60 bar H2 , 140 C), with maximum TOFs of 5250 h(-1) (7 a(syn,anti)) and 8200 h(-1) (7 b(syn,anti)) for 1-hexene hydrogenation. Alkenes 90-96 synemin Homo sapiens 10-13 25125283-5 2014 The 7 a,b(syn,anti)/Et3 SiH/B(C6 F5 )3 co-catalytic systems were highly active in various olefin hydrogenations (60 bar H2 , 140 C), with maximum TOFs of 5250 h(-1) (7 a(syn,anti)) and 8200 h(-1) (7 b(syn,anti)) for 1-hexene hydrogenation. Alkenes 90-96 synemin Homo sapiens 171-174 25125283-5 2014 The 7 a,b(syn,anti)/Et3 SiH/B(C6 F5 )3 co-catalytic systems were highly active in various olefin hydrogenations (60 bar H2 , 140 C), with maximum TOFs of 5250 h(-1) (7 a(syn,anti)) and 8200 h(-1) (7 b(syn,anti)) for 1-hexene hydrogenation. Alkenes 90-96 synemin Homo sapiens 171-174 25010426-5 2014 The formed Cu-H promotes the reduction of alkyl halides to give alkanes and Cu-X or the generation of Cu(0), probably by disproportionation, which can oxidatively add to alkyl halides to yield olefins and, in some cases, homocoupling products. Alkenes 193-200 cut like homeobox 1 Homo sapiens 76-80 25062387-0 2014 Diversity-oriented syntheses: coupling reactions between electron-deficient olefins and aryl aldehydes via C(sp2)-H functionalization. Alkenes 76-83 Sp2 transcription factor Homo sapiens 107-112 25207804-1 2014 The hydrocarbon-stapled peptide E1(S) allosterically inhibits the kinase activity of the epidermal growth factor receptor (EGFR) by blocking a distant but essential protein-protein interaction: a coiled coil formed from the juxtamembrane segment (JM) of each member of the dimeric partnership.1 Macrocyclization is not required for activity: the analogous unstapled (but alkene-bearing) peptide is equipotent in cell viability, immunoblot, and bipartite display experiments to detect coiled coil formation on the cell surface. Alkenes 371-377 epidermal growth factor receptor Homo sapiens 89-121 25207804-1 2014 The hydrocarbon-stapled peptide E1(S) allosterically inhibits the kinase activity of the epidermal growth factor receptor (EGFR) by blocking a distant but essential protein-protein interaction: a coiled coil formed from the juxtamembrane segment (JM) of each member of the dimeric partnership.1 Macrocyclization is not required for activity: the analogous unstapled (but alkene-bearing) peptide is equipotent in cell viability, immunoblot, and bipartite display experiments to detect coiled coil formation on the cell surface. Alkenes 371-377 epidermal growth factor receptor Homo sapiens 123-127 24991280-0 2014 Synthesis of chiral N-phosphoryl aziridines through enantioselective aziridination of alkenes with phosphoryl azide via Co(II)-based metalloradical catalysis. Alkenes 86-93 mitochondrially encoded cytochrome c oxidase II Homo sapiens 120-125 25152544-4 2014 Thereby, exo,exo-5-norbornene-2,3-dimethanol was found to be almost as reactive as unsubstituted norbornene whereas (+-)-endo,exo-dimethyl-5-norbornene-2,3-dicarboxylate reacted only insignificanty faster than unstrained alkenes. Alkenes 221-228 exonuclease 5 Homo sapiens 13-18 25075553-1 2014 A Rh-catalyzed oxidative dehydrogenative cross-coupling of 1,4-naphthquinones with alkenes was achieved by using a substituent-enabled C(sp(2))-H functionalization (SEF) strategy. Alkenes 83-90 transcription factor CP2 Homo sapiens 165-168 24957504-2 2014 Herein, a homogeneous Pd-complex-catalyzed transformation of terminal alkenes into primary allylic alcohols, by using 5 mol % [Pd(PPh3)4] as a catalyst, and H2O, CO2, and quinone derivatives as reagents, is reported. Alkenes 70-77 caveolin 1 Homo sapiens 130-134 24823713-4 2014 Moreover, a robust strategy for the introduction of the exo-methylene group at C-3, commonly found in many sesquiterpenes, was developed that makes use of masking the alkene in the alpha,beta-unsaturated carbonyl system by O-pivaoyl, which is stable under acidic and mild basic conditions but eliminated upon treatment with strong bases. Alkenes 167-173 complement C3 Homo sapiens 79-82 25075434-1 2014 The cationic ruthenium catalyst generated upon the acid-base reaction of H2Ru(CO)(PPh3)3 and 2,4,6-(2-Pr)3PhSO3H promotes the redox-triggered C-C coupling of 2-alkynes and primary alcohols to form (Z)-homoallylic alcohols with good to complete control of olefin geometry. Alkenes 255-261 protein phosphatase 4 catalytic subunit Homo sapiens 82-86 25484848-3 2014 Two new rings are formed in this alkene carboamination reaction where N-sulfonyl-2-aryl-4-pentenamines are converted to 6-azabicyclo[3.2.1]octanes using [Ph-Box-Cu](OTf)2 or related catalysts in the presence of MnO2 as stoichiometric oxidant in moderate to good yields and generally excellent enantioselectivities. Alkenes 33-39 POU class 2 homeobox 2 Homo sapiens 165-170 25010511-1 2014 Stereoselective palladium-catalyzed oxidative C-N bond coupling reactions between aromatic amines and alkenes involving a solvent-controlled regioselective bromination process under 1 atm of oxygen atmosphere are disclosed, providing easy access to two different brominated enamines. Alkenes 102-109 ATM serine/threonine kinase Homo sapiens 184-187 24938206-0 2014 Influence of catalyst structure and reaction conditions on anti- versus syn-aminopalladation pathways in Pd-catalyzed alkene carboamination reactions of N-allylsulfamides. Alkenes 118-124 synemin Homo sapiens 72-75 24938206-2 2014 In contrast to other known Pd-catalyzed alkene carboamination reactions, these transformations may be selectively induced to occur by way of either anti- or syn-aminopalladation mechanistic pathways by modifying the catalyst structure and reaction conditions. Alkenes 40-46 synemin Homo sapiens 157-160 24991280-1 2014 The Co(II) complex of a new D 2-symmetric chiral porphyrin 3,5-DiMes-QingPhyrin, [Co(P6)], can catalyze asymmetric aziridination of alkenes with bis(2,2,2-trichloroethyl)phosphoryl azide (TcepN3) as a nitrene source. Alkenes 132-139 mitochondrially encoded cytochrome c oxidase II Homo sapiens 4-9 24644140-1 2014 A general epoxidation of aromatic and aliphatic olefins has been developed under mild conditions using heterogeneous Cox Oy -N/C (x=1,3; y=1,4) catalysts and tert-butyl hydroperoxide as the terminal oxidant. Alkenes 48-55 cytochrome c oxidase subunit 8A Homo sapiens 117-120 24561005-0 2014 Inhibitory potency of 4-carbon alkanes and alkenes toward CYP2E1 activity. Alkenes 43-50 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 58-64 24573047-0 2014 Copper-catalysed oxidative C-H/C-H coupling between olefins and simple ethers. Alkenes 52-59 churchill domain containing 1 Homo sapiens 27-34 24561005-2 2014 In this study, we determined the potency of inhibition of human CYP2E1 for various 4-carbon alkanes, alkenes and alcohols. Alkenes 101-108 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 64-70 24171583-2 2013 Alkene ozonolysis is also known to directly form HO2 radicals, which may be readily converted to OH through reaction with NO, but whose formation is poorly understood. Alkenes 0-6 heme oxygenase 2 Homo sapiens 49-52 24552627-2 2014 By utilizing [IrCl(COD)]2 in the presence of excess COD, hydrosilylation of alkenes and alkynes with ethynylsilanes is achieved with good chemo- and regioselectivity. Alkenes 76-83 COD2 Homo sapiens 19-25 24395081-1 2014 From the interplay of STM imaging and DFT calculations we have investigated the isomerization of an alkene molecule on Cu(110) under ultrahigh vacuum conditions. Alkenes 100-106 sulfotransferase family 1A member 3 Homo sapiens 22-25 25615668-0 2014 Catalytic, stereospecific syn-dichlorination of alkenes. Alkenes 48-55 synemin Homo sapiens 26-29 25615668-3 2014 Here, we describe the first catalytic, syn-stereospecific dichlorination of alkenes, employing a group transfer catalyst based on a redox-active main group element (selenium). Alkenes 76-83 synemin Homo sapiens 39-42 24354601-0 2014 Free-radical cascade alkylarylation of alkenes with simple alkanes: highly efficient access to oxindoles via selective (sp3)C-H and (sp2)C-H bond functionalization. Alkenes 39-46 Sp3 transcription factor Homo sapiens 120-123 24354601-0 2014 Free-radical cascade alkylarylation of alkenes with simple alkanes: highly efficient access to oxindoles via selective (sp3)C-H and (sp2)C-H bond functionalization. Alkenes 39-46 Sp2 transcription factor Homo sapiens 133-136 23964958-10 2013 Two-photon excited CCl4 or CHCl3 can also ionize the diene or alkene solute. Alkenes 62-68 C-C motif chemokine ligand 4 Homo sapiens 19-23 24203915-0 2013 Ligand-metal cooperating PC(sp3)P pincer complexes as catalysts in olefin hydroformylation. Alkenes 67-73 Sp3 transcription factor Homo sapiens 28-31 24645640-3 2014 The reaction provides high levels of 5-exo selectivity, and terminally monosubstituted alkenes result in predominant syn-diastereoselectivity. Alkenes 87-94 synemin Homo sapiens 117-120 24326345-1 2014 The reaction of high-valent fac-{(99m)TcO3}(+) complexes with alkenes ((3 + 2)-cycloaddition) has been used to develop a novel labelling procedure for silica based particles. Alkenes 62-69 FA complementation group C Homo sapiens 28-31 24132303-6 2013 In particular, Fe/MOF-74 is shown to be a unique system where the guest-dependent magnetic transition observed only for the olefin adsorption is a secondary reason for the high olefin-paraffin adsorption selectivity measured. Alkenes 124-130 lysine acetyltransferase 8 Homo sapiens 18-21 24132303-6 2013 In particular, Fe/MOF-74 is shown to be a unique system where the guest-dependent magnetic transition observed only for the olefin adsorption is a secondary reason for the high olefin-paraffin adsorption selectivity measured. Alkenes 177-183 lysine acetyltransferase 8 Homo sapiens 18-21 24171583-3 2013 We report a study of the radical (OH, HO2, and RO2) production from a series of small alkenes (propene, 1-butene, cis-2-butene, trans-2-butene, 2-methylpropene, 2,3-dimethyl-2-butene (tetramethyl ethene, TME), and isoprene). Alkenes 86-93 heme oxygenase 2 Homo sapiens 38-41 24171583-7 2013 Increasing humidity further reduced the HO2 yields obtained, by typically 50% for an RH increase from 0.5 to 30%, suggesting that HOx production from alkene ozonolysis may be lower than current models suggest under (humid) ambient atmospheric boundary layer conditions. Alkenes 150-156 heme oxygenase 2 Homo sapiens 40-43 24000239-1 2013 Pin it down: A highly enantioselective diboration of terminal alkenes with chiral 1 and bis(pinacolato)diboron (B2 pin2 ) was realized. Alkenes 62-69 dynein light chain LC8-type 1 Homo sapiens 0-3 24105732-1 2013 A one-pot method has been developed for the oxidative cleavage of internal alkenes into aldehydes by using 0.5 mol% of the nonheme iron complex [Fe(OTf)2(mix-bpbp)] (bpbp=N,N"-bis(2-picolyl)-2,2"-bipyrrolidine) as catalyst and 1.5 equivalents of hydrogen peroxide and 1 equivalent of sodium periodate as oxidants. Alkenes 75-82 POU class 2 homeobox 2 Homo sapiens 148-153 24102289-1 2013 Allylic amination reactions of alkenes, with an NBP (N-bromophthalimide) or NBS (N-bromosuccinimide)/DBU combination, were developed, in which both internal and external nitrogen nucleophiles can be installed directly. Alkenes 31-38 nibrin Homo sapiens 76-79 24204414-2 2013 A regio- and diastereoselective Co(II)-catalyzed hydration of the olefin and a transannular epoxide opening were used as the key reactions. Alkenes 66-72 mitochondrially encoded cytochrome c oxidase II Homo sapiens 32-37 23959581-1 2013 A beta-barrel protein hybrid catalyst was prepared by covalently anchoring a Grubbs-Hoveyda type olefin metathesis catalyst at a single accessible cysteine amino acid in the barrel interior of a variant of beta-barrel transmembrane protein ferric hydroxamate uptake protein component A (FhuA). Alkenes 97-103 amyloid beta precursor protein Homo sapiens 0-6 23881641-5 2013 In contrast for ETO, the Ea value is approximately 60 kJ mol(-1) , which is comparable to the Ea values for the condensation of light olefins into aromatics. Alkenes 134-141 RUNX1 partner transcriptional co-repressor 1 Homo sapiens 16-19 24025085-2 2013 Predominant syn addition of the chlorenium and the nucleophile across the olefin is observed. Alkenes 74-80 synemin Homo sapiens 12-15 23613312-1 2013 We have designed the cyclopropane analog of stilbene as subtype-selective ligands for estrogen receptor based on the bioisosterism that cyclopropane could act as alkene bioisoster. Alkenes 162-168 estrogen receptor 1 Homo sapiens 86-103 23949625-1 2013 Several closely related palladium-catalysed reactions involve the addition of Pd-C across an alkene, and subsequent beta-elimination of Pd-H to give a more substituted alkene. Alkenes 93-99 phosducin Homo sapiens 78-82 23949625-1 2013 Several closely related palladium-catalysed reactions involve the addition of Pd-C across an alkene, and subsequent beta-elimination of Pd-H to give a more substituted alkene. Alkenes 93-99 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 136-140 23949625-1 2013 Several closely related palladium-catalysed reactions involve the addition of Pd-C across an alkene, and subsequent beta-elimination of Pd-H to give a more substituted alkene. Alkenes 168-174 phosducin Homo sapiens 78-82 23949625-1 2013 Several closely related palladium-catalysed reactions involve the addition of Pd-C across an alkene, and subsequent beta-elimination of Pd-H to give a more substituted alkene. Alkenes 168-174 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 136-140 23855956-1 2013 The divergent synthesis of syn-1,2-aminoalcohol or syn-1,2-diamine precursors from a common terminal olefin has been accomplished using a combination of palladium(II) catalysis with Lewis acid cocatalysis. Alkenes 101-107 synapsin I Homo sapiens 27-32 23855956-1 2013 The divergent synthesis of syn-1,2-aminoalcohol or syn-1,2-diamine precursors from a common terminal olefin has been accomplished using a combination of palladium(II) catalysis with Lewis acid cocatalysis. Alkenes 101-107 synapsin I Homo sapiens 51-56 23865980-0 2013 Fast CO2 sequestration, activation, and catalytic transformation using N-heterocyclic olefins. Alkenes 86-93 complement C2 Homo sapiens 5-8 23677698-2 2013 Electrophilic and nucleophilic oxygens (O(elec) and O(nuc)) that might be important for olefin epoxidation in a low-oxygen coverage condition were focused here. Alkenes 88-94 nucleobindin 1 Homo sapiens 18-21 23679128-1 2013 The first asymmetric catalytic biomimetic three-component 1,3-dipolar cycloaddition of alpha-keto esters and benzylamine with electron-deficient olefins, inspired by the transamination of alpha-keto acids involving pyridoxal phosphate (PLP)-dependent enzymes in biological systems, giving several families of structurally diverse pyrrolidine derivatives in high yields and excellent enantioselectivities (up to 99% ee) under mild conditions is described. Alkenes 145-152 pyridoxal phosphatase Homo sapiens 236-239 23862564-2 2013 In contrast to the previously proposed syn-oxypalladation mechanism for acyclic monoallylic diols, calculations and experiments strongly suggest that hydrogen bonding templates a hydroxyl group and Pd addition across the alkene and provides a low energy pathway via anti-addition (anti-oxypalladation) followed by intramolecular proton transfer and anti-elimination of water. Alkenes 221-227 synemin Homo sapiens 39-42 23845496-2 2013 The selective addition of sulfite to the alkene of TSP assisted by cetyltrimethyl ammonium bromide (CTAB) micelle can be visualized by dramatic color and ratiometric fluorescence changes. Alkenes 41-47 thrombospondin 1 Homo sapiens 51-54 23829768-1 2013 In this work, we present high-pressure rate rules and branching ratios for the addition of HO2 to olefins through the concerted addition channel to form an alkyl peroxy radical (HO2 + olefin RO2) and through the radical addition channel to form a beta-hydroperoxy alkyl radical (HO2 + olefin beta-QOOH). Alkenes 98-105 heme oxygenase 2 Homo sapiens 91-94 23829768-1 2013 In this work, we present high-pressure rate rules and branching ratios for the addition of HO2 to olefins through the concerted addition channel to form an alkyl peroxy radical (HO2 + olefin RO2) and through the radical addition channel to form a beta-hydroperoxy alkyl radical (HO2 + olefin beta-QOOH). Alkenes 98-105 heme oxygenase 2 Homo sapiens 178-181 23829768-1 2013 In this work, we present high-pressure rate rules and branching ratios for the addition of HO2 to olefins through the concerted addition channel to form an alkyl peroxy radical (HO2 + olefin RO2) and through the radical addition channel to form a beta-hydroperoxy alkyl radical (HO2 + olefin beta-QOOH). Alkenes 98-105 heme oxygenase 2 Homo sapiens 178-181 23862690-3 2013 Reaction progress kinetic analysis and kinetic isotope effects suggest that the stereodefining step in the catalytic cycle is olefin migratory insertion into a Pt-B bond. Alkenes 126-132 polypyrimidine tract binding protein 1 Homo sapiens 160-164 23712417-1 2013 Recently, Lewis acidic calcium salts bearing weakly coordinating anions such as Ca(NTf2)2, Ca(OTf)2, CaF2 and Ca[OCH(CF3)2]2 have been discovered as catalysts for the transformation of alcohols, olefins and carbonyl compounds. Alkenes 195-202 nuclear transport factor 2 Homo sapiens 83-87 23712417-1 2013 Recently, Lewis acidic calcium salts bearing weakly coordinating anions such as Ca(NTf2)2, Ca(OTf)2, CaF2 and Ca[OCH(CF3)2]2 have been discovered as catalysts for the transformation of alcohols, olefins and carbonyl compounds. Alkenes 195-202 POU class 2 homeobox 2 Homo sapiens 94-99 23712417-1 2013 Recently, Lewis acidic calcium salts bearing weakly coordinating anions such as Ca(NTf2)2, Ca(OTf)2, CaF2 and Ca[OCH(CF3)2]2 have been discovered as catalysts for the transformation of alcohols, olefins and carbonyl compounds. Alkenes 195-202 CCR4-NOT transcription complex subunit 8 Homo sapiens 101-105 23525234-0 2013 CAL-B catalyzed desymmetrization of 3-alkylglutarate: "olefin effect" and asymmetric synthesis of pregabalin. Alkenes 55-61 calbindin 1 Homo sapiens 0-5 24900739-4 2013 In contrast, type B physalins with C5-C6 olefin functionality inhibited nuclear translocation and DNA binding of RelA/p50 protein dimer, which lie downstream of IkappaBalpha degradation, although withanolides having the same AB-ring functionality did not. Alkenes 41-47 RELA proto-oncogene, NF-kB subunit Homo sapiens 113-117 24900739-4 2013 In contrast, type B physalins with C5-C6 olefin functionality inhibited nuclear translocation and DNA binding of RelA/p50 protein dimer, which lie downstream of IkappaBalpha degradation, although withanolides having the same AB-ring functionality did not. Alkenes 41-47 nuclear factor kappa B subunit 1 Homo sapiens 118-121 24900739-4 2013 In contrast, type B physalins with C5-C6 olefin functionality inhibited nuclear translocation and DNA binding of RelA/p50 protein dimer, which lie downstream of IkappaBalpha degradation, although withanolides having the same AB-ring functionality did not. Alkenes 41-47 NFKB inhibitor alpha Homo sapiens 161-173 23675870-2 2013 The MAZ serves as a divalent reversible chain-transfer agent for olefin polymerization, resulting in telechelic Zn-metalated polyolefins whose molecular weights are controllable over a wide range. Alkenes 65-71 MYC associated zinc finger protein Homo sapiens 4-7 23379769-0 2013 Atom-economical chemoselective synthesis of 1,4-enynes from terminal alkenes and propargylic alcohols catalyzed by Cu(OTf)2. Alkenes 69-76 POU class 2 homeobox 2 Homo sapiens 118-123 23316939-0 2013 The isolation of [Pd{OC(O)H}(H)(NHC)(PR3)] (NHC = N-heterocyclic carbene) and its role in alkene and alkyne reductions using formic acid. Alkenes 90-96 proteinase 3 Homo sapiens 37-40 23575886-0 2013 PPh3-mediated intramolecular conjugation of alkyl halides with electron-deficient olefins: facile synthesis of chromans and relevant analogues. Alkenes 82-89 caveolin 1 Homo sapiens 0-4 23471689-1 2013 Metal-free synthesis: Diamination of alkenes by using phenylhydrazine and azodicarboxylates could be achieved in a one-pot manner under very mild conditions (see scheme; Boc = tert-butoxycarbonyl). Alkenes 37-44 BOC cell adhesion associated, oncogene regulated Homo sapiens 170-173 23379769-1 2013 A novel and efficient Cu(OTf)2-catalyzed sp(3)-sp(2) C-C bond formation reaction through the direct coupling of propargylic alcohols with terminal alkenes has been realized under mild conditions. Alkenes 147-154 POU class 2 homeobox 2 Homo sapiens 25-30 23289770-0 2013 Stereoselective Rh2(S-IBAZ)4-catalyzed cyclopropanation of alkenes, alkynes, and allenes: asymmetric synthesis of diacceptor cyclopropylphosphonates and alkylidenecyclopropanes. Alkenes 59-66 Rh associated glycoprotein Homo sapiens 16-19 23303703-0 2013 Selective metal-catalyzed transfer of H2 and CO from polyols to alkenes. Alkenes 64-71 relaxin 2 Homo sapiens 38-47 23337905-0 2013 Metal-free syn-dioxygenation of alkenes. Alkenes 32-39 synemin Homo sapiens 11-14 23337905-4 2013 This review describes the methods available for metal-free syn-dioxygenation of alkenes. Alkenes 80-87 synemin Homo sapiens 59-62 23202443-0 2013 Asymmetric cyclopropanation of olefins catalysed by Cu(I) complexes of chiral pyridine-containing macrocyclic ligands (Pc-L*). Alkenes 31-38 PHD finger protein 1 Homo sapiens 119-124 23254388-0 2013 Tandem ammonia borane dehydrogenation/alkene hydrogenation mediated by [Pd(NHC)(PR3)] (NHC = N-heterocyclic carbene) catalysts. Alkenes 38-44 proteinase 3 Homo sapiens 80-83 23256882-0 2013 Influence of temperature and pressure on cyclic carbonate synthesis catalyzed by bimetallic aluminum complexes and application to overall syn-bis-hydroxylation of alkenes. Alkenes 163-170 synemin Homo sapiens 58-61 23256882-4 2013 This allowed a route for the overall syn-bis-hydroxylation of alkenes to be developed without the use of hazardous metal based reagents. Alkenes 62-69 synemin Homo sapiens 37-40 22481574-4 2012 Entry of the hybrid olefin-NSHC and halide ligands ejects either one (5, 6 and 7) phosphine ligand or keeps both phosphines (4) by replacing the acetate. Alkenes 20-26 SHC adaptor protein 3 Homo sapiens 27-31 22953753-3 2012 The surface-specific activity (apparent TOF) based on the initial activity of unpromoted catalysts at 1 bar increased 6-8-fold when the average iron carbide size decreased from 7 to 2 nm, while methane and lower olefins selectivity were not affected. Alkenes 212-219 FEZ family zinc finger 2 Homo sapiens 40-43 22849590-3 2012 The pi bonding patterns in these boron nanoladders bear similarities to those in conjugated alkenes: H(2)B(7)(-), H(2)B(8), and H(2)B(9)(-), each with two pi bonds, are similar to butadiene, while H(2)B(10)(2-), H(2)B(11)(-), and H(2)B(12), each with three pi bonds, are analogous to 1,3,5-hexatriene. Alkenes 92-99 H2B clustered histone 21 Homo sapiens 101-106 22690888-0 2012 Metal-free, organocatalytic syn diacetoxylation of alkenes. Alkenes 51-58 synemin Homo sapiens 28-31 22690888-1 2012 A novel method for the organocatalytic syn diacetoxylation of alkenes has been developed using aryl iodides as efficient catalysts. Alkenes 62-69 synemin Homo sapiens 39-42 22540125-0 2012 Controlled growth of narrowly dispersed nanosize hexagonal MOF rods from Mn(III)-porphyrin and In(NO3)3 and their application in olefin oxidation. Alkenes 129-135 lysine acetyltransferase 8 Homo sapiens 59-62 23096590-1 2012 An amine-functionalized zirconium metal-organic framework (MOF) was used as a visible-light photocatalyst for selective aerobic oxygenation of various organic compounds including alcohols, olefins and cyclic alkanes, at high efficiency and high selectivity. Alkenes 189-196 lysine acetyltransferase 8 Homo sapiens 34-63 23113538-0 2012 An osmium(III)/osmium(V) redox couple generating Os(V)(O)(OH) center for cis-1,2-dihydroxylation of alkenes with H2O2: Os complex with a nitrogen-based tetradentate ligand. Alkenes 100-107 cytokine inducible SH2 containing protein Homo sapiens 73-78 23113538-1 2012 For the synthesis of the 1,2-diols, cis-1,2-dihydroxylation of alkenes catalyzed by osmium(VIII) tetroxide (OsO(4)) is a powerful method. Alkenes 63-70 cytokine inducible SH2 containing protein Homo sapiens 36-41 23113538-1 2012 For the synthesis of the 1,2-diols, cis-1,2-dihydroxylation of alkenes catalyzed by osmium(VIII) tetroxide (OsO(4)) is a powerful method. Alkenes 63-70 cytochrome c oxidase subunit 8A Homo sapiens 91-95 23113538-3 2012 Thus, the development of alternative catalysts for cis-1,2-dihydroxylation of alkenes is highly challenging. Alkenes 78-85 cytokine inducible SH2 containing protein Homo sapiens 51-56 23113538-5 2012 The new Os-tpa complex acts as a very efficient turnover catalyst for syn-selective dihydroxylation of various alkenes (turnover number ~1000) in aqueous media, and H(2)O(2) oxidant is formally incorporated into the products quantitatively (100% atom efficiency). Alkenes 111-118 synemin Homo sapiens 70-73 23113538-7 2012 The observed syn-selectivity, structural characteristics of the intermediates, and kinetic studies have suggested a concerted [3 + 2]-cycloaddition mechanism between [Os(V)(O)(OH)(tpa)](2+) and alkenes, which is strongly supported by DFT calculations. Alkenes 194-201 synemin Homo sapiens 13-16 23077980-1 2012 The enthalpies of reduction of carbonyl compounds and hydrogenation of alkenes have been calculated at the HF, B3LYP, M06, MP2, G3, G4, CBS-QB3, CBS-APNO, and W1BD levels and, in the case of the first four methods, using a variety of basis sets up to aug-cc-pVTZ. Alkenes 71-78 tryptase pseudogene 1 Homo sapiens 123-126 22889014-4 2012 Olefin epoxidation by this catalytic system is proposed to involve a new reactive Co(II)-OOC(O)R species, based on evidence from H(2)(18)O-exchange experiments, the use of peroxyphenylacetic acid as a mechanistic probe, reactivity and Hammett studies, EPR, and ESI-mass spectrometric investigation. Alkenes 0-6 mitochondrially encoded cytochrome c oxidase II Homo sapiens 82-87 22777682-4 2012 Once the eta(2),eta(3)-cycloheptadienyl complex has been formed, isomerization to eta(5)-cycloheptadienyl again involves several steps: olefin decoordination, beta-hydride elimination, reinsertion, and olefin coordination; also here the initial decoordination step is rate limiting. Alkenes 136-142 endothelin receptor type A Homo sapiens 9-12 22777682-4 2012 Once the eta(2),eta(3)-cycloheptadienyl complex has been formed, isomerization to eta(5)-cycloheptadienyl again involves several steps: olefin decoordination, beta-hydride elimination, reinsertion, and olefin coordination; also here the initial decoordination step is rate limiting. Alkenes 136-142 endothelin receptor type A Homo sapiens 16-19 22777682-4 2012 Once the eta(2),eta(3)-cycloheptadienyl complex has been formed, isomerization to eta(5)-cycloheptadienyl again involves several steps: olefin decoordination, beta-hydride elimination, reinsertion, and olefin coordination; also here the initial decoordination step is rate limiting. Alkenes 136-142 endothelin receptor type A Homo sapiens 16-19 22777682-4 2012 Once the eta(2),eta(3)-cycloheptadienyl complex has been formed, isomerization to eta(5)-cycloheptadienyl again involves several steps: olefin decoordination, beta-hydride elimination, reinsertion, and olefin coordination; also here the initial decoordination step is rate limiting. Alkenes 202-208 endothelin receptor type A Homo sapiens 9-12 22481574-5 2012 It is also possible to accommodate two NSHC ligands by keeping the olefin pendant (6). Alkenes 67-73 SHC adaptor protein 3 Homo sapiens 39-43 22461419-2 2012 This nonheme Co(III) complex catalyzes olefin epoxidation upon treatment with meta-chloroperbenzoic acid. Alkenes 39-45 mitochondrially encoded cytochrome c oxidase III Homo sapiens 13-20 22475216-5 2012 Among olefins, the 4,5-olefin 12 (IC(50) = 0.135 muM) revealed the best activity, pointing out the importance of planarity in the A,B-ring junction near C-5. Alkenes 6-13 latexin Homo sapiens 49-52 22431359-7 2012 By using functionalised ligands bearing terminal olefins, double ring-closing metathesis leads to [2]catenanes in good yield with Fe(II) or Co(III) as the templating metal centre. Alkenes 49-56 mitochondrially encoded cytochrome c oxidase III Homo sapiens 140-147 22352868-0 2012 Structure-activity relationship study of a CXC chemokine receptor type 4 antagonist, FC131, using a series of alkene dipeptide isosteres. Alkenes 110-116 C-X-C motif chemokine receptor 4 Homo sapiens 43-72 22352383-0 2012 Stereoselective synthesis of cis-2,5-disubstituted pyrrolidines via Wacker-type aerobic oxidative cyclization of alkenes with tert-butanesulfinamide nucleophiles. Alkenes 113-120 suppressor of cytokine signaling 2 Homo sapiens 29-34 22360738-2 2012 An alkynyl diazo ester under Rh(II) catalysis is employed for cyclopropanations of electron-rich olefins while an alkynyl sulfonium ylide is used for electron-poor olefins. Alkenes 97-104 Rh blood group D antigen Homo sapiens 29-35 22360738-2 2012 An alkynyl diazo ester under Rh(II) catalysis is employed for cyclopropanations of electron-rich olefins while an alkynyl sulfonium ylide is used for electron-poor olefins. Alkenes 164-171 Rh blood group D antigen Homo sapiens 29-35 22372402-6 2012 Complex 2 was applied in the catalytic epoxidation of the biorenewable olefins DL-limonene (Lim) and methyl oleate (Ole), using tert-butylhydroperoxide (TBHP) as an oxygen donor, under mild reaction conditions (55 C, air). Alkenes 71-78 PDZ and LIM domain 5 Homo sapiens 92-95 22364208-3 2012 New kinetic (global analysis) and computational (DFT) data explain the crucial role of the anion in suppressing decomposition and catalyzing the formation of the interligand product through a dimetallic complex that appears to catalyze alkene addition across the Ni-S bond, leading to a lower barrier for the interligand adduct. Alkenes 236-242 solute carrier family 5 member 5 Homo sapiens 263-267 21989593-4 2011 In addition, the reactivity of the complexes cis-4, trans-4 and 8 towards alkenes and CO was studied using NMR experiments. Alkenes 74-81 suppressor of cytokine signaling 6 Homo sapiens 45-50 22161727-1 2012 A Co-based metal-organic framework (MOF) was investigated as a catalytic material in the aerobic epoxidation of olefins in DMF and exhibited, based on catalyst mass, a remarkably high catalytic activity compared with the Co-doped zeolite catalysts that are typically used in this reaction. Alkenes 112-119 lysine acetyltransferase 8 Homo sapiens 11-40 22423287-2 2012 For most of the olefins, the reactions afforded the C(sp3)-C(sp2) cross-coupling products, but for the alpha-methylstyrene and 1-hexene, the C(sp3)-C(sp3) cross-coupling products were obtained. Alkenes 16-23 Sp2 transcription factor Homo sapiens 59-64 22269866-4 2012 The strategic role of (TMS)(3)SiH in polymerization is underlined with emphasis on the photo-induced radical polymerization of olefins and photo-promoted cationic polymerization of epoxides. Alkenes 127-134 PYD and CARD domain containing Homo sapiens 23-26 21875065-0 2011 Regio- and stereoselective syntheses of the natural product CCR5 antagonist anibamine and its three olefin isomers. Alkenes 100-106 C-C motif chemokine receptor 5 Homo sapiens 60-64 21909523-1 2011 [Fe(Por)CF(3)SO(3)] (Por = porphyrin dianion) can efficiently catalyze selective oxidation of terminal aryl alkenes and aliphatic alkenes to aldehydes in good to high yields under mild conditions. Alkenes 108-115 cytochrome p450 oxidoreductase Homo sapiens 4-7 21909523-1 2011 [Fe(Por)CF(3)SO(3)] (Por = porphyrin dianion) can efficiently catalyze selective oxidation of terminal aryl alkenes and aliphatic alkenes to aldehydes in good to high yields under mild conditions. Alkenes 108-115 cytochrome p450 oxidoreductase Homo sapiens 21-24 22070230-3 2011 This reagent, which was prepared via a Rh(II)- or Cu(I)-catalyzed carbenoid Si-H insertion, was used to introduce the desired olefin geometry and stereocenters of the C1-C5 propionate subunit. Alkenes 126-132 Rh blood group D antigen Homo sapiens 39-46 22092171-1 2011 Selective syn and anti diacetoxylations of alkenes have been achieved using a PhI(OAc)(2)/BF(3) OEt(2) system in the presence and absence of water, respectively. Alkenes 43-50 synemin Homo sapiens 10-13 21548649-0 2011 Asymmetric Rh(II)-catalyzed cyclopropanation of alkenes with diacceptor diazo compounds: p-methoxyphenyl ketone as a general stereoselectivity controlling group. Alkenes 48-55 Rh blood group D antigen Homo sapiens 11-17 21647990-0 2011 Asymmetric cycloaddition of beta,gamma-unsaturated alpha-ketoesters with electron-rich alkenes catalyzed by a chiral Er(OTf)3/N,N"-dioxide complex: highly enantioselective synthesis of 3,4-dihydro-2H-pyrans. Alkenes 87-94 POU class 5 homeobox 1 Homo sapiens 120-125 21829832-12 2011 The Phoban and Lim systems are superior with the highest reactivity and lowest alkene loss through hydrogenation. Alkenes 79-85 PDZ and LIM domain 5 Homo sapiens 15-18 21797255-2 2011 The key step in the synthesis is the NBS olefin activation to facilitate the addition of a guanidine molecule across the double bond. Alkenes 41-47 nibrin Homo sapiens 37-40 21681331-1 2011 The palladium-assisted one-pot three-component reactions of aldehydes, amines and olefins proceeded smoothly to give 2,6-unsubstituted 1,4-dihydropyridines (1,4-DHPs) using molecular oxygen as a sole oxidant. Alkenes 82-89 deoxyhypusine synthase Homo sapiens 161-165 21678509-4 2011 DFT studies on the entire RCM catalytic cycle of hindered olefins were performed to rationalize the different behaviors of catalysts with syn- and anti-methyl groups on the NHC backbone. Alkenes 58-65 synemin Homo sapiens 138-141 21483935-2 2011 The computations clearly indicate the involvement of a cobalt "nitrene radical" intermediate in the Co(II)(por)-catalyzed alkene aziridination. Alkenes 122-128 mitochondrially encoded cytochrome c oxidase II Homo sapiens 100-105 21476495-0 2011 Potent macrocyclic inhibitors of insulin-regulated aminopeptidase (IRAP) by olefin ring-closing metathesis. Alkenes 76-82 leucyl and cystinyl aminopeptidase Homo sapiens 33-65 21476495-0 2011 Potent macrocyclic inhibitors of insulin-regulated aminopeptidase (IRAP) by olefin ring-closing metathesis. Alkenes 76-82 leucyl and cystinyl aminopeptidase Homo sapiens 67-71 21495703-1 2011 Epoxidation of olefin by [Ru(TMP)(CO)(O)](-) (TMP = tetramesitylporphine), which is a key step of the photocatalyzed epoxidation of olefin by [Ru(TMP)(CO)], is studied mainly with the density functional theory (DFT) method, where [Ru(Por)(CO)] is employed as a model complex (Por = unsubstituted porphyrin). Alkenes 15-21 cytochrome p450 oxidoreductase Homo sapiens 234-237 21523276-2 2011 Aziridination of various olefins, such as the unreactive olefins e.g. ethylhex-2-enoate and 1-decene, with N-tosyliminophenyliodinane catalyzed by [Cu(NCR)(6)][Al(OC(CF(3))(2)R")(4)](2) affords very good yields (up to 96%) and high TOFs (up to 5000 h(-1)) under mild conditions. Alkenes 25-32 Neutrophil migration (granulocyte glycoprotein) Homo sapiens 151-154 21523276-2 2011 Aziridination of various olefins, such as the unreactive olefins e.g. ethylhex-2-enoate and 1-decene, with N-tosyliminophenyliodinane catalyzed by [Cu(NCR)(6)][Al(OC(CF(3))(2)R")(4)](2) affords very good yields (up to 96%) and high TOFs (up to 5000 h(-1)) under mild conditions. Alkenes 57-64 Neutrophil migration (granulocyte glycoprotein) Homo sapiens 151-154 21534607-1 2011 Enantioselective intramolecular oxidative amidation of alkenes has been achieved using a (pyrox)Pd(II)(TFA)(2) catalyst (pyrox = pyridine-oxazoline, TFA = trifluoroacetate) and O(2) as the sole stoichiometric oxidant. Alkenes 55-62 coagulation factor III, tissue factor Homo sapiens 103-106 21534607-1 2011 Enantioselective intramolecular oxidative amidation of alkenes has been achieved using a (pyrox)Pd(II)(TFA)(2) catalyst (pyrox = pyridine-oxazoline, TFA = trifluoroacetate) and O(2) as the sole stoichiometric oxidant. Alkenes 55-62 coagulation factor III, tissue factor Homo sapiens 149-152 21495703-1 2011 Epoxidation of olefin by [Ru(TMP)(CO)(O)](-) (TMP = tetramesitylporphine), which is a key step of the photocatalyzed epoxidation of olefin by [Ru(TMP)(CO)], is studied mainly with the density functional theory (DFT) method, where [Ru(Por)(CO)] is employed as a model complex (Por = unsubstituted porphyrin). Alkenes 15-21 cytochrome p450 oxidoreductase Homo sapiens 276-279 21495703-1 2011 Epoxidation of olefin by [Ru(TMP)(CO)(O)](-) (TMP = tetramesitylporphine), which is a key step of the photocatalyzed epoxidation of olefin by [Ru(TMP)(CO)], is studied mainly with the density functional theory (DFT) method, where [Ru(Por)(CO)] is employed as a model complex (Por = unsubstituted porphyrin). Alkenes 132-138 cytochrome p450 oxidoreductase Homo sapiens 234-237 21495703-1 2011 Epoxidation of olefin by [Ru(TMP)(CO)(O)](-) (TMP = tetramesitylporphine), which is a key step of the photocatalyzed epoxidation of olefin by [Ru(TMP)(CO)], is studied mainly with the density functional theory (DFT) method, where [Ru(Por)(CO)] is employed as a model complex (Por = unsubstituted porphyrin). Alkenes 132-138 cytochrome p450 oxidoreductase Homo sapiens 276-279 21495703-11 2011 (v) The stability of the olefin adduct [Ru(Por)(CO)(O)(olefin)](-) considerably depends on the kind of olefin, such as ethylene, n-hexene, and styrene. Alkenes 25-31 cytochrome p450 oxidoreductase Homo sapiens 43-46 21495703-11 2011 (v) The stability of the olefin adduct [Ru(Por)(CO)(O)(olefin)](-) considerably depends on the kind of olefin, such as ethylene, n-hexene, and styrene. Alkenes 55-61 cytochrome p450 oxidoreductase Homo sapiens 43-46 21634191-4 2011 Furthermore, the column chromatography and GC-MS analysis revealed that content of lightly components including saturated and aromatic hydrocarbons exceeded 40%, specifically was alkenes (> C15), hydrocarbon derivatives, and a small amount aromatic hydrocarbons. Alkenes 179-186 placenta associated 8 Homo sapiens 193-196 21391709-3 2011 To obtain the desired precursor (2S,5R)-2-allyl-5-vinylpyrrolidine for RCM reaction, we developed a general and practical method for the preparation of enantiopure cis-2,5-disubstituted pyrrolidines bearing alkene- and/or alkyne-containing substituents. Alkenes 207-213 suppressor of cytokine signaling 2 Homo sapiens 164-169 21387480-0 2011 "Hydro-metathesis" of olefins: a catalytic reaction using a bifunctional single-site tantalum hydride catalyst supported on fibrous silica (KCC-1) Nanospheres. Alkenes 22-29 solute carrier family 12 member 4 Homo sapiens 140-145 21350780-3 2011 The resulting "ArS(+)" pool reacted with alkenes and alkynes to give diarylthio-substituted products. Alkenes 41-48 RIEG2 Homo sapiens 15-18 21380431-1 2011 The manganese(V) nitrido complex (PPh(4))(2)[Mn(N)(CN)(4)] is an active catalyst for alkene epoxidation and alcohol oxidation using H(2)O(2) as an oxidant. Alkenes 85-91 potassium two pore domain channel subfamily K member 3 Homo sapiens 34-40 21250701-2 2011 We report a highly stereoselective 6-exo radical cyclization/ring-closing olefin metathesis sequence to construct the syn/trans-fused polyether system. Alkenes 74-80 synemin Homo sapiens 118-121 21038071-1 2011 The simultaneous isomorphous substitution of Al(III) and P(V) ions, in an aluminophosphate framework, with redox active Co(III) and Ti(IV) metal ions, generates highly active single-site heterogeneous catalysts that exhibit considerable synergy, compared to their corresponding monometallic analogues, in the catalytic epoxidation of olefins. Alkenes 334-341 mitochondrially encoded cytochrome c oxidase III Homo sapiens 48-51 21247150-2 2011 In intermolecular, nonchelation-controlled transformations LPd(IV)Cl(4) reacted with alkenes and alkynes to 1,2-dichlorination adducts. Alkenes 85-92 acyl-CoA synthetase bubblegum family member 1 Homo sapiens 59-62 21247150-6 2011 Product stereochemistry and product distributions from various alkenes also support Cl(+)-transfer from the pentacoordinated Pd(IV)-intermediate LPd(IV)Cl(3)(+) to olefins. Alkenes 63-70 acyl-CoA synthetase bubblegum family member 1 Homo sapiens 145-148 21247150-6 2011 Product stereochemistry and product distributions from various alkenes also support Cl(+)-transfer from the pentacoordinated Pd(IV)-intermediate LPd(IV)Cl(3)(+) to olefins. Alkenes 164-171 acyl-CoA synthetase bubblegum family member 1 Homo sapiens 145-148 21038071-1 2011 The simultaneous isomorphous substitution of Al(III) and P(V) ions, in an aluminophosphate framework, with redox active Co(III) and Ti(IV) metal ions, generates highly active single-site heterogeneous catalysts that exhibit considerable synergy, compared to their corresponding monometallic analogues, in the catalytic epoxidation of olefins. Alkenes 334-341 mitochondrially encoded cytochrome c oxidase III Homo sapiens 120-127 22054130-7 2011 In analogy to [OsO(4)] and [RuO(4)], complexes containing the fac-{TcO(3)}(+) core undergo with alkenes metal-mediated, vicinal cis-dihydroxylation reactions (alkene-glycol interconversion) in water via a (3+2)-cycloaddition reaction. Alkenes 96-103 FA complementation group C Homo sapiens 62-65 20727702-5 2011 The structure of the process-related impurity was established as carbamic acid-2-carbamoyloxymethyl-2-methyl-pent-3-enyl ester (olefin). Alkenes 128-134 PTOV1 extended AT-hook containing adaptor protein Homo sapiens 74-80 21049111-0 2011 Osmium-free direct syn-dihydroxylation of alkenes. Alkenes 42-49 synemin Homo sapiens 19-22 21049111-1 2011 Numerous synthetic protocols for producing syn-diols from the corresponding alkenes have been developed and published over recent years. Alkenes 76-83 synemin Homo sapiens 9-12 21049111-2 2011 It is the intent of the following tutorial review to present a concise summary of the main methods used to prepare syn-diol fragments directly from alkene precursors, and that do not make use of osmium oxo complexes as catalysts. Alkenes 148-154 synemin Homo sapiens 115-118 22054130-7 2011 In analogy to [OsO(4)] and [RuO(4)], complexes containing the fac-{TcO(3)}(+) core undergo with alkenes metal-mediated, vicinal cis-dihydroxylation reactions (alkene-glycol interconversion) in water via a (3+2)-cycloaddition reaction. Alkenes 96-102 FA complementation group C Homo sapiens 62-65 21069994-5 2010 Alkene geometry of the products is a complex function of the allylic alcohol structure and is consistent with a mechanistic proposal based on syn-carbometalation followed by syn-elimination by way of a boat-like transition state geometry. Alkenes 0-6 synemin Homo sapiens 142-145 21031177-3 2010 The olefin complexes [Cu(Ar-dpa)(styrene)]BF(4) for Ar = Ph (13), Mes (14), 2-(i)PrC(6)H(4) (15), and 1-naph (16), in addition to the norborylene complexes of Ar = Mes (17) and 2-(i)PrC(6)H(4) (18) have been prepared and characterized by (1)H and (13)C NMR, FTIR, and TGA. Alkenes 4-10 T-box transcription factor 1 Homo sapiens 268-271 20981670-10 2010 It is demonstrated that 2 catalyzes the formation of phosphorane utilizing EDA and PPh(3), which subsequently reacts with aldehyde to produce a new olefin and phosphine oxide. Alkenes 148-154 caveolin 1 Homo sapiens 83-89 21069994-5 2010 Alkene geometry of the products is a complex function of the allylic alcohol structure and is consistent with a mechanistic proposal based on syn-carbometalation followed by syn-elimination by way of a boat-like transition state geometry. Alkenes 0-6 synemin Homo sapiens 174-177 20738239-5 2010 The structural requirement of Mrp2/Abcc2 recognition was further explored in a series of thiophene amides derivatives divided into eight structural classes, with structural changes focused on the amide linker orientation or substitution from amide and sulfonamide to alkene, alkane, or alkyne linkers. Alkenes 267-273 ATP binding cassette subfamily C member 2 Homo sapiens 30-34 20944847-2 2010 Treatment of the latter with 3-(2-(2-bromoethoxy)ethoxy)prop-1-ene under basic conditions yields ligand 4 containing pendant, alkene-terminated chains. Alkenes 126-132 PROP paired-like homeobox 1 Homo sapiens 56-62 20972491-1 2010 The addition of HCN to alkenes is a very useful reaction for the synthesis of functional organic substrates. Alkenes 23-30 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 16-19 20866083-4 2010 The putative Fe(V)(O)(O(2)CAr) oxidant decays either by undergoing oxidative decarboxylation and subsequent ipso-hydroxylation to form the observed phenol product or by oxo-transfer to olefins to form epoxide. Alkenes 185-192 FEV transcription factor, ETS family member Homo sapiens 13-18 20866057-0 2010 Alkene syn dihydroxylation with malonoyl peroxides. Alkenes 0-6 synemin Homo sapiens 7-10 20866083-5 2010 The observed higher yield of phenol over epoxide or cis-diol in all cases studied, where an electron-withdrawing benzoic acid is present in the reaction mixture, suggests that intramolecular decay of the putative Fe(V)(O)(O(2)CAr) oxidant is favored over intermolecular olefin oxidation. Alkenes 270-276 FEV transcription factor, ETS family member Homo sapiens 213-218 20701322-2 2010 Previous experimental and computational work suggests that for many alkenes the measured *OH yields should be attributed to the combined impact of both chemically activated and thermalized syn-alkyl Criegee intermediates (CIs), even though the thermalized CI should be susceptible to trapping by molecules such as water. Alkenes 68-75 synemin Homo sapiens 189-192 20822182-1 2010 Direct C-4-selective addition of pyridine across alkenes and alkynes is achieved for the first time by nickel/Lewis acid cooperative catalysis with an N-heterocyclic carbene ligand. Alkenes 49-56 complement C4A (Rodgers blood group) Homo sapiens 7-10 20831167-0 2010 Alkene hydroboration: hot intermediates that react while they are cooling. Alkenes 0-6 alcohol dehydrogenase iron containing 1 Homo sapiens 22-25 20617793-3 2010 In order of decreasing molar yields, alkene products from 1-5MeH decomposition are ethene, isobutene, propene, 3-methylbut-1-ene, but-1-ene, E/Z-hex-2-ene, 4-methylpent-1-ene, and hex-1-ene. Alkenes 37-43 exonuclease 1 Homo sapiens 180-185 20698535-2 2010 The determined substrate preferences are proved to be dependent on the molecular identity of the catalyst, exhibiting the preference order of alkyne > alkene > allene for Mo-1 and Mo-2, allene > alkene > alkyne for Ru-1 and Ru-3, and alkyne > allene > alkene for Ru-2 and Ru-4. Alkenes 154-160 Scm like with four mbt domains 1 Homo sapiens 227-240 20698535-2 2010 The determined substrate preferences are proved to be dependent on the molecular identity of the catalyst, exhibiting the preference order of alkyne > alkene > allene for Mo-1 and Mo-2, allene > alkene > alkyne for Ru-1 and Ru-3, and alkyne > allene > alkene for Ru-2 and Ru-4. Alkenes 154-160 doublecortin domain containing 2 Homo sapiens 281-285 20698535-2 2010 The determined substrate preferences are proved to be dependent on the molecular identity of the catalyst, exhibiting the preference order of alkyne > alkene > allene for Mo-1 and Mo-2, allene > alkene > alkyne for Ru-1 and Ru-3, and alkyne > allene > alkene for Ru-2 and Ru-4. Alkenes 204-210 Scm like with four mbt domains 1 Homo sapiens 227-240 20698535-2 2010 The determined substrate preferences are proved to be dependent on the molecular identity of the catalyst, exhibiting the preference order of alkyne > alkene > allene for Mo-1 and Mo-2, allene > alkene > alkyne for Ru-1 and Ru-3, and alkyne > allene > alkene for Ru-2 and Ru-4. Alkenes 204-210 doublecortin domain containing 2 Homo sapiens 281-285 20698535-2 2010 The determined substrate preferences are proved to be dependent on the molecular identity of the catalyst, exhibiting the preference order of alkyne > alkene > allene for Mo-1 and Mo-2, allene > alkene > alkyne for Ru-1 and Ru-3, and alkyne > allene > alkene for Ru-2 and Ru-4. Alkenes 204-210 Scm like with four mbt domains 1 Homo sapiens 227-240 20698535-2 2010 The determined substrate preferences are proved to be dependent on the molecular identity of the catalyst, exhibiting the preference order of alkyne > alkene > allene for Mo-1 and Mo-2, allene > alkene > alkyne for Ru-1 and Ru-3, and alkyne > allene > alkene for Ru-2 and Ru-4. Alkenes 204-210 doublecortin domain containing 2 Homo sapiens 281-285 20681723-0 2010 "Carbene radicals" in Co(II)(por)-catalyzed olefin cyclopropanation. Alkenes 44-50 cytochrome p450 oxidoreductase Homo sapiens 29-32 20681723-5 2010 The calculations suggest that the formation of the carbene is the rate-limiting step for the unfunctionalized Co(II)(por) and that the cyclopropane ring formation proceeds via a stepwise radical process: Radical addition of the "carbene radical" C to the C=C double bonds of the olefins results in formation of the gamma-alkyl radical intermediates D. Species D then easily collapse in almost barrierless ring-closure reactions (TS3) to form the cyclopropanes. Alkenes 279-286 cytochrome p450 oxidoreductase Homo sapiens 110-121 20681723-6 2010 This radical mechanism readily explains the high activity of Co(II)(por) species in the cyclopropanation of electron-deficient olefins such as methyl acrylate. Alkenes 127-134 cytochrome p450 oxidoreductase Homo sapiens 68-71 20572169-3 2010 The reaction mechanism has been largely debated in the literature; two modes for the nucleophilic addition of water to a Pd-coordinated alkene have been proposed: syn-inner- and anti-outer-sphere mechanisms. Alkenes 136-142 synemin Homo sapiens 163-166 20582360-17 2010 Some preliminary catalytic studies showed that the Mn compounds 1 and 2 were active (high yield within 3 min) for alkene epoxidation with peracetic acid and hydrogen peroxide dismutation (catalase activity). Alkenes 114-120 catalase Homo sapiens 188-196 20594838-3 2010 The alkene isostere exhibited a K(D)=90 microM in comparison to the native peptide (K(D)=2.3 microM) and Lac mutant (K(D)=2300 microM). Alkenes 4-10 lactase Homo sapiens 105-108 20397666-3 2010 These complexes undergo syn-migratory insertion of the alkene into the Pd-N bond to yield observable (dppf)palladium(aryl)(pyrrolidin-2-yl-methyl) complexes 6. Alkenes 55-61 synemin Homo sapiens 24-27 20397251-0 2010 BCl3-mediated ene reaction of sulfur dioxide and unfunctionalized alkenes. Alkenes 66-73 BCL3 transcription coactivator Homo sapiens 0-4 20372736-0 2010 Synthesis and exchange reactions of Ni-dimine-COD, acetylene and olefin complexes. Alkenes 65-71 small nuclear ribonucleoprotein polypeptides B and B1 Homo sapiens 46-49 20481452-0 2010 Shutting down secondary reaction pathways: the essential role of the pyrrolyl ligand in improving silica supported d(0)-ML4 alkene metathesis catalysts from DFT calculations. Alkenes 124-130 mucolipin TRP cation channel 1 Homo sapiens 120-123 20397666-7 2010 These are the first examples of syn-migratory insertions of unactivated alkenes into Pd-N bonds of well-defined complexes. Alkenes 72-79 synemin Homo sapiens 32-35 20502656-2 2010 Our synthetic route to the cyclooctadiene-derived scaffolds 16a-d takes advantage of the facile isolation of a novel spirocyclic precursor 9b with the crucial syn-orientation of its two alkene moieties. Alkenes 186-192 synemin Homo sapiens 4-7 20386850-1 2010 2-(3-Benzyloxy)prop-1-ynyl)benzaldehyde with PtCl(2) in toluene would form Pt-pyryliums that underwent [3+2] cycloaddition with alkenes to the oxygen-bridged (5H-benzo[7]annulen-5-ylidene)platinum(ii) intermediates with good stereoselectivities. Alkenes 128-135 PROP paired-like homeobox 1 Homo sapiens 15-21 20949433-6 2010 The cysteine S-conjugate beta-lyase pathway is of particular interest to toxicologists because it is involved in the bioactivation (toxification) of halogenated alkenes and certain drugs. Alkenes 161-168 kynurenine aminotransferase 1 Homo sapiens 4-35 20102231-0 2010 PdCl2(HNMe2)2-catalyzed highly selective cross [2 + 2 + 2] cyclization of alkynoates and alkenes under molecular oxygen. Alkenes 89-96 phosducin like 2 Homo sapiens 0-5 20234900-4 2010 First, technologies based on the production of synthesis gas, i.e., Fischer-Tropsch synthesis as well as MTO/MTP (Methanol To Olefins/Methanol To Propylene), are discussed. Alkenes 126-133 metallothionein 1B Homo sapiens 105-112 20128611-1 2010 The mechanism and regioselectivity of the osmium-catalyzed aminohydroxylation of olefins was investigated in detail by density functional theory (B3LYP/6-31G(d)) calculations in the gas phase and with the CPCM-solvent model. Alkenes 81-88 protein tyrosine phosphatase non-receptor type 22 Homo sapiens 148-151 20131803-3 2010 The olefin metathesis of H(4)L(1) selectively produced trans-H(4)L(2) while the reaction of [L(1)Zn(2)Ca] exclusively afforded cis-H(4)L(2). Alkenes 4-10 L1 cell adhesion molecule Homo sapiens 29-33 20131803-3 2010 The olefin metathesis of H(4)L(1) selectively produced trans-H(4)L(2) while the reaction of [L(1)Zn(2)Ca] exclusively afforded cis-H(4)L(2). Alkenes 4-10 immunoglobulin kappa variable 3-15 Homo sapiens 65-69 20090978-0 2010 Synthesis and biological evaluation of selective CXCR4 antagonists containing alkene dipeptide isosteres. Alkenes 78-84 C-X-C motif chemokine receptor 4 Homo sapiens 49-54 20050647-3 2010 This study constitutes the first example of catalytically converting C(sp(3))-Au bonds into C(sp(3))--C(sp(2)) bonds in a cross-coupling manner and opens new opportunities to study gold alkene catalysis where alkylgold intermediates can be readily functionalized intermolecularly. Alkenes 186-192 regulator of calcineurin 2 Homo sapiens 102-109 19835391-2 2009 The key steps of the synthetic strategy were a high regio- and complete stereoselective 1,3-dipolar cycloaddition of alkene 6 with nitrone 5, a Tamao-Fleming reaction for replacing the silicon substituent with a hydroxy group with retention of configuration, and a Mitsunobu reaction to establish the correct configuration of the target molecule at C-6. Alkenes 117-123 complement C6 Homo sapiens 349-352 20000619-1 2010 Efficient and selective ATRA reactions of CCl(4), CBr(4), TsCl (Ts = tosyl), or Cl(3)CCO(2)Et with activated olefins (styrene, methyl methacrylate, n-butyl methacrylate, tert-butyl methacrylate) using the Tp(tBu)Cu(NCMe) complex as a catalyst have been achieved in the absence of any reductant and with low catalyst loadings. Alkenes 109-116 carbonyl reductase 4 Homo sapiens 50-55 20023998-0 2010 Olefin metathesis as a tool for multinuclear Co(III)salen catalyst construction: access to cooperative catalysts. Alkenes 0-6 mitochondrially encoded cytochrome c oxidase III Homo sapiens 48-51 19826724-5 2009 With 10 mol% of [Cl2(PCy3)2Ru=CHPh] the rac-4 diastereoisomer underwent a clean intramolecular ring-closing olefin metathesis reaction to yield the ansa-zirconocene complex rac-6. Alkenes 108-114 Rac family small GTPase 1 pseudogene 4 Homo sapiens 40-45 19950647-7 2009 The bond length of chains (olefins) is shorter than that of rings, so their vibrational frequency is higher and the G-peak position moves to higher frequencies with increasing the sp3 fraction. Alkenes 27-34 Sp3 transcription factor Homo sapiens 180-183 19751053-1 2009 Inter- and intramolecular additions of alkyl radicals, generated by SET photochemical decarboxylation reactions of free carboxylic acids, to electron-deficient alkenes take place under mild conditions as part of efficient routes for the formation of N-Boc gamma-amino acids and macrocyclic lactones. Alkenes 160-167 BOC cell adhesion associated, oncogene regulated Homo sapiens 252-255 19702329-0 2009 Pt-catalyzed enantioselective diboration of terminal alkenes with B2(pin)2. Alkenes 53-60 telomeric repeat binding factor 1 Homo sapiens 66-74 19746977-13 2009 Easy chain transfer was suggested to proceed from the more stable PdH(olefin) complex 12" if beta-hydride elimination to 12" does take place. Alkenes 70-76 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 66-69 19746977-14 2009 Thus, the production of linear polyethylene with high molecular weight under ethylene pressure suggests that the cis and trans PdH(alkene)(phosphine-sulfonate) complexes (12 and 12") are merely accessible in the presence of excess amount of ethylene. Alkenes 131-137 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 127-130 19681580-0 2009 Silicon powder: the first nonmetal elemental catalyst for aminobromination of olefins with TsNH(2) and NBS. Alkenes 78-85 nibrin Homo sapiens 103-106 19621913-2 2009 This synthetic strategy relies on the ability of mannose-derived nitrone to undergo a highly stereoselective nucleophilic addition of various Grignard reagents to access syn orientation of alkenes, which then smoothly undergo ring-closing metathesis (RCM) to provide this framework. Alkenes 189-196 synemin Homo sapiens 5-8 19641786-0 2009 KI-catalyzed aminobromination of olefins with TsNH(2)-NBS combination. Alkenes 33-40 nibrin Homo sapiens 54-57 19603748-0 2009 Synthesis and structure of PNP-supported iridium silyl and silylene complexes: catalytic hydrosilation of alkenes. Alkenes 106-113 purine nucleoside phosphorylase Homo sapiens 27-30 19603748-6 2009 Catalytic hydrosilation of alkenes by hydrogen-substituted silylene complexes [(PNP)(H)Ir=SiMes(H)][B(C(6)F(5))(4)] (1) and 14 exhibited anti-Markovnikov regioselectivity with an array of alkene substrates. Alkenes 27-33 purine nucleoside phosphorylase Homo sapiens 80-83 19603748-6 2009 Catalytic hydrosilation of alkenes by hydrogen-substituted silylene complexes [(PNP)(H)Ir=SiMes(H)][B(C(6)F(5))(4)] (1) and 14 exhibited anti-Markovnikov regioselectivity with an array of alkene substrates. Alkenes 27-34 purine nucleoside phosphorylase Homo sapiens 80-83 19523824-1 2009 Cyclization of recently reported linear phosphino dipeptide isostere inhibitors of BACE1 via side chain olefin metathesis yielded macrocyclic BACE1 inhibitors. Alkenes 104-110 beta-secretase 1 Homo sapiens 83-88 19719250-4 2009 The pi-olefin-Pd complexes I and II are proposed as important intermediates to explain the syn- and anti-oxypalladation pathways. Alkenes 7-13 synemin Homo sapiens 91-94 19572601-0 2009 Taco complex templated syntheses of a cryptand/paraquat [2]rotaxane and a [2]catenane by olefin metathesis. Alkenes 89-95 coronin 1A Homo sapiens 0-4 19523824-1 2009 Cyclization of recently reported linear phosphino dipeptide isostere inhibitors of BACE1 via side chain olefin metathesis yielded macrocyclic BACE1 inhibitors. Alkenes 104-110 beta-secretase 1 Homo sapiens 142-147 19585042-1 2009 A Co(II)-based catalytic system has been developed for asymmetric aziridination of alkenes with trichloroethoxysulfonyl azide (TcesN3) under mild conditions, forming the corresponding N-Tces-aziridines in high yields and excellent enantioselectivities. Alkenes 83-90 mitochondrially encoded cytochrome c oxidase II Homo sapiens 2-7 19505107-3 2009 The present work suggests a novel, yet simple, method toward quantifying the conjugation in a general olefin group (e.g., alkenes) on a linear scale, defined as the "olefinicity scale", achieved using the computed enthalpy of hydrogenation (DeltaH(H2)) of the compound examined. Alkenes 102-108 relaxin 2 Homo sapiens 241-250 19587988-1 2009 Plausible mechanisms of olefin epoxidation catalysed by a V-salan model complex [VIV(=O)(L)(H2O)] (1, L=(CH2NHCH2CH=CHO-)2) in the presence of H2O2 are investigated and compared by theoretical methods using density functional theory. Alkenes 24-30 EBP cholestenol delta-isomerase Homo sapiens 116-122 19505107-3 2009 The present work suggests a novel, yet simple, method toward quantifying the conjugation in a general olefin group (e.g., alkenes) on a linear scale, defined as the "olefinicity scale", achieved using the computed enthalpy of hydrogenation (DeltaH(H2)) of the compound examined. Alkenes 122-129 relaxin 2 Homo sapiens 241-250 19421978-0 2009 Osmabenzenes from osmacycles containing an eta2-coordinated olefin. Alkenes 60-66 DNA polymerase iota Homo sapiens 43-47 19408926-0 2009 Cu(I)-catalyzed diamination of disubstituted terminal olefins: an approach to potent NK1 antagonist. Alkenes 54-61 tachykinin receptor 1 Homo sapiens 85-88 19413344-2 2009 The Co(II)-catalyzed reaction is suitable for various olefins, providing the desired cyclopropane succinimidyl esters in high yields and excellent diastereo- and enantioselectivity. Alkenes 54-61 mitochondrially encoded cytochrome c oxidase II Homo sapiens 4-9 19590744-0 2009 The development and evaluation of a continuous flow process for the lipase-mediated oxidation of alkenes. Alkenes 97-104 PAN0_003d1715 Moesziomyces antarcticus 68-74 19156283-10 2009 A good correlation exists between the 1HNMRDd values and the TGA data, confirming that the shift of the olefin NMR resonances upon coordination is associated with the binding strength of the complex. Alkenes 104-110 T-box transcription factor 1 Homo sapiens 61-64 19590744-1 2009 We report the use of an immobilised form of Candida antarctica lipase B, Novozym((R)) 435, in a preliminary investigation into the development of a continuous flow reactor capable of performing the chemo-enzymatic oxidation of alkenes in high yield and purity, utilising the commercially available oxidant hydrogen peroxide (100 volumes). Alkenes 227-234 PAN0_003d1715 Moesziomyces antarcticus 63-69 19590744-2 2009 Initial investigations focussed on the lipase-mediated oxidation of 1-methylcyclohexene, with the optimised reaction conditions subsequently employed for the epoxidation of an array of aromatic and aliphatic alkenes in 97.6 to 99.5% yield and quantitative purity. Alkenes 208-215 PAN0_003d1715 Moesziomyces antarcticus 39-45 19400559-1 2009 The reactivity of olefin containing complexes of the d(8) metals Ru(0) and Rh(I) toward GaCp* and AlCp* is presented. Alkenes 18-24 glutaminase Homo sapiens 88-92 19421509-0 2009 Physisorption and chemisorption of alkanes and alkenes in H-FAU: a combined ab initio-statistical thermodynamics study. Alkenes 47-54 FAU ubiquitin like and ribosomal protein S30 fusion Homo sapiens 60-63 19206234-0 2009 Fe(OTf)(3)-catalyzed addition of sp C-H bonds to olefins. Alkenes 49-56 POU class 5 homeobox 1 Homo sapiens 0-9 19206234-0 2009 Fe(OTf)(3)-catalyzed addition of sp C-H bonds to olefins. Alkenes 49-56 surfactant protein C Homo sapiens 33-37 19206234-4 2009 Among relatively hard acids, Fe(OTf)(3) was the best catalyst, which is also the case for ester formation from carboxylic acids and olefins. Alkenes 132-139 POU class 5 homeobox 1 Homo sapiens 29-38 19343246-0 2009 Synthesis of cyclic peptide analogues of the 3(10) helical Pro138-Gly144 segment of human aquaporin-4 by olefin metathesis. Alkenes 105-111 aquaporin 4 Homo sapiens 90-101 19343246-1 2009 Four cyclic pentapeptides and two cyclic heptapeptides modelled on the 3(10) helical Pro138-Gly144 segment of the water channel aquaporin-4 (AQP4) postulated to mediate adhesive interactions between AQP4 tetramers were synthesised by olefin metathesis. Alkenes 234-240 aquaporin 4 Homo sapiens 128-139 19343246-1 2009 Four cyclic pentapeptides and two cyclic heptapeptides modelled on the 3(10) helical Pro138-Gly144 segment of the water channel aquaporin-4 (AQP4) postulated to mediate adhesive interactions between AQP4 tetramers were synthesised by olefin metathesis. Alkenes 234-240 aquaporin 4 Homo sapiens 141-145 19275264-2 2009 Tridentate dianionic pyridine-2,6-dicarboxamido ligands, each with two terminal alkene groups, coordinate Co(III) in a mutually orthogonal arrangement such that entwined or interlocked molecular architectures are produced by ring-closing olefin metathesis. Alkenes 80-86 mitochondrially encoded cytochrome c oxidase III Homo sapiens 106-113 19275264-2 2009 Tridentate dianionic pyridine-2,6-dicarboxamido ligands, each with two terminal alkene groups, coordinate Co(III) in a mutually orthogonal arrangement such that entwined or interlocked molecular architectures are produced by ring-closing olefin metathesis. Alkenes 238-244 mitochondrially encoded cytochrome c oxidase III Homo sapiens 106-113 26610108-3 2009 The SCSC-MP2 method has improved performance for modeling Grubbs II olefin metathesis catalysts as compared to canonical MP2 or SCS-MP2. Alkenes 68-74 tryptase pseudogene 1 Homo sapiens 9-12 19378567-1 2009 The complex [Tpm(*,Br)Cu(NCMe)]BF4 (Tpm(*,Br) = HC(3,5-Me2-4-Br-pyrazolyl)3) catalyses the aziridination of alkenes and the amidation of cyclic ethers with chloramine-T as the nitrene source and the ionic liquid [bmim]PF6 as the reaction medium (bmim = 1-n-butyl-3-methylimidazolium). Alkenes 108-115 sperm associated antigen 17 Homo sapiens 218-221 19266521-3 2009 These reactions are relevant to catalytic chain transfer (CCT) in radical polymerization of olefins mediated by [Co(II)(por)](*), the formation and homolysis of organo-cobalt complexes that mediate living radical polymerization of vinyl acetate, and cobalt-mediated hydrogenation of olefins. Alkenes 92-99 cytochrome p450 oxidoreductase Homo sapiens 120-123 19116994-0 2009 Titanium-catalyzed hydroaminoalkylation of alkenes by C-H bond activation at sp3 centers in the alpha-position to a nitrogen atom. Alkenes 43-50 Sp3 transcription factor Homo sapiens 77-80 19943296-0 2009 Intramolecular alkynylcyclopropanation of olefins catalyzed by Bi(OTf)3: stereoselective synthesis of 1-alkynyl-3-azabicyclo[3.1.0]hexanes. Alkenes 42-49 POU class 5 homeobox 1 Homo sapiens 66-71 19229935-1 2009 The kinetics of the reductive elimination step of a C(sp(3))-C(sp(2)) Negishi cross-coupling catalyzed by a 1:1 complex 2 of palladium and the phosphine/electron-deficient olefin ligand (E)-3-(2-diphenylphosphanylphenyl)-1-phenyl-propenone (1) was studied. Alkenes 172-178 regulator of calcineurin 2 Homo sapiens 61-68 19266521-3 2009 These reactions are relevant to catalytic chain transfer (CCT) in radical polymerization of olefins mediated by [Co(II)(por)](*), the formation and homolysis of organo-cobalt complexes that mediate living radical polymerization of vinyl acetate, and cobalt-mediated hydrogenation of olefins. Alkenes 283-290 CCT Homo sapiens 58-61 19266521-0 2009 Hydrogen-atom transfer in reactions of organic radicals with [Co(II)(por)]* (por = porphyrinato) and in subsequent addition of [Co(H)(por)] to olefins. Alkenes 143-150 mitochondrially encoded cytochrome c oxidase II Homo sapiens 62-67 19266521-0 2009 Hydrogen-atom transfer in reactions of organic radicals with [Co(II)(por)]* (por = porphyrinato) and in subsequent addition of [Co(H)(por)] to olefins. Alkenes 143-150 cytochrome p450 oxidoreductase Homo sapiens 69-72 19266521-0 2009 Hydrogen-atom transfer in reactions of organic radicals with [Co(II)(por)]* (por = porphyrinato) and in subsequent addition of [Co(H)(por)] to olefins. Alkenes 143-150 cytochrome p450 oxidoreductase Homo sapiens 77-80 19266521-0 2009 Hydrogen-atom transfer in reactions of organic radicals with [Co(II)(por)]* (por = porphyrinato) and in subsequent addition of [Co(H)(por)] to olefins. Alkenes 143-150 cytochrome p450 oxidoreductase Homo sapiens 77-80 19266521-3 2009 These reactions are relevant to catalytic chain transfer (CCT) in radical polymerization of olefins mediated by [Co(II)(por)](*), the formation and homolysis of organo-cobalt complexes that mediate living radical polymerization of vinyl acetate, and cobalt-mediated hydrogenation of olefins. Alkenes 283-290 mitochondrially encoded cytochrome c oxidase II Homo sapiens 113-118 19266521-3 2009 These reactions are relevant to catalytic chain transfer (CCT) in radical polymerization of olefins mediated by [Co(II)(por)](*), the formation and homolysis of organo-cobalt complexes that mediate living radical polymerization of vinyl acetate, and cobalt-mediated hydrogenation of olefins. Alkenes 92-99 CCT Homo sapiens 58-61 19266521-3 2009 These reactions are relevant to catalytic chain transfer (CCT) in radical polymerization of olefins mediated by [Co(II)(por)](*), the formation and homolysis of organo-cobalt complexes that mediate living radical polymerization of vinyl acetate, and cobalt-mediated hydrogenation of olefins. Alkenes 283-290 cytochrome p450 oxidoreductase Homo sapiens 120-123 19266521-3 2009 These reactions are relevant to catalytic chain transfer (CCT) in radical polymerization of olefins mediated by [Co(II)(por)](*), the formation and homolysis of organo-cobalt complexes that mediate living radical polymerization of vinyl acetate, and cobalt-mediated hydrogenation of olefins. Alkenes 92-99 mitochondrially encoded cytochrome c oxidase II Homo sapiens 113-118 19266521-8 2009 Insertion of vinyl acetate into the Co-H bond of [Co(III)(H)(por)] also proceeds over a low barrier (DeltaG(double dagger) = +11.4 kcal mol(-1)) hydrogen-transfer step from [Co(III)(H)(por)] to a carbon atom of the alkene to produce a close-contact radical pair. Alkenes 215-221 cytochrome p450 oxidoreductase Homo sapiens 61-64 19266521-10 2009 The computed energies obtained for the hydrogen-atom transfer reactions from (*)C(CH(3))(2)CN to [Co(II)(por)](*) and from [Co(H)(por)] to olefins, as well as the organo-cobalt bond homolysis energies correspond well with the experimental observations. Alkenes 139-146 cytochrome p450 oxidoreductase Homo sapiens 130-133 19266521-11 2009 The mechanism of alkene insertion into the Co-H bond of [Co(III)(H)(por)] is of general interest, because the species does not contain any cis-vacant sites to the hydride and the usual migratory insertion pathway is not available. Alkenes 17-23 cytochrome p450 oxidoreductase Homo sapiens 68-71 18931770-1 2008 The three-component coupling of benzynes with terminal alkynes and activated alkenes in the presence of CuI, PCy(3) and CsF in a 1:1 mixture of CH(3)CN and THF at 50 degrees C for 5 h gave 1-alkyl-2-alkynylbenzenes in good to moderate yields. Alkenes 77-84 colony stimulating factor 2 Homo sapiens 120-123 19053466-2 2008 The intermolecular Pauson-Khand reaction (PKR), a carbonylative cycloaddition between an alkyne and an alkene, is a convenient method to prepare cyclopentenones. Alkenes 103-109 eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens 42-45 18821802-2 2008 The reaction occurs between N-Boc or N-Cbz imines, generated in situ from stable and easy to handle N-Boc or N-Cbz protected alpha-amidoalkyl-p-tolylsulfones, and electron-deficient alkenes in the presence of DABCO. Alkenes 182-189 BOC cell adhesion associated, oncogene regulated Homo sapiens 30-33 18821802-2 2008 The reaction occurs between N-Boc or N-Cbz imines, generated in situ from stable and easy to handle N-Boc or N-Cbz protected alpha-amidoalkyl-p-tolylsulfones, and electron-deficient alkenes in the presence of DABCO. Alkenes 182-189 BOC cell adhesion associated, oncogene regulated Homo sapiens 102-105 18826324-3 2008 Upon treatment with 2 equiv of PPh3 and DIAD, elimination of SR and OH moieties from 3 affords the corresponding olefins 4 in moderate to good yield. Alkenes 113-120 caveolin 1 Homo sapiens 31-35 18937477-6 2008 These labeling studies also imply that more favorable partitioning of the eta2-imine complex toward reaction with alkene versus regeneration of the starting bis-amido complex accounts for the higher reactivity of the mixed halide amido catalyst versus a homoleptic amido complex. Alkenes 114-120 DNA polymerase iota Homo sapiens 74-78 18937221-1 2008 Electrophilic additions of hydrogen halides to alkenes in the gas phase are investigated with a high-level ab initio method, MP2/6-311+G(3df,2p). Alkenes 47-54 tryptase pseudogene 1 Homo sapiens 125-128 18720969-1 2008 Alkenes can be stereoselectively arylated and vinylated without transition-metal catalyst under mild conditions through an interesting NBS-promoted semipinacol rearrangement and a subsequent unusual NaOH-mediated Grob fragmentation. Alkenes 0-7 C-X-C motif chemokine ligand 2 Homo sapiens 213-217 18630965-3 2008 Expulsion of neutral alkenes via syn-elimination to give ionized ArOH does not exhibit a pronounced preference with regard to the direction of elimination. Alkenes 21-28 synemin Homo sapiens 33-36 18720969-0 2008 Arylation and vinylation of alkenes based on unusual sequential semipinacol rearrangement/Grob fragmentation of allylic alcohols. Alkenes 28-35 C-X-C motif chemokine ligand 2 Homo sapiens 90-94 18845896-3 2008 Meanwhile, in the case of the ionic liquids with BF(4), PF(6) and CF(3)SO(3) anions, corresponding alkenes were predominantly produced along with 1-alkylimidazoles rather than haloalkanes. Alkenes 99-106 sperm associated antigen 17 Homo sapiens 56-61 18633494-1 2008 Hollow, hexa-porphyrin prisms of two sizes were template-assembled and covalently locked, via cross-olefin metathesis, into permanent, torsionally rigid structures whose active sites (metal sites) can be both accessed and altered in a facile manner. Alkenes 100-106 hexosaminidase subunit alpha Homo sapiens 8-12 18651776-3 2008 The C-H BDEs for the alkenes yielding the alkyl radicals cyclopenten-4-yl and cyclohexen-4-yl and the alpha-C-H BDE in cyclopentene were also calculated. Alkenes 21-28 homeobox D13 Homo sapiens 8-11 18616253-2 2008 Thus, the metallacyclobutene complex (eta5-C5H5)(PPh3)Co[kappa2-(C,C)-C(SO2Ph) C(Si(CH3)3)CH(CO2CH2CH3)] (2) undergoes reaction with alkenes to give 1,4-diene complexes with a high degree of regio- and stereoselectivity. Alkenes 133-140 caveolin 1 Homo sapiens 49-53 18510331-0 2008 Olefin metathesis catalyst: stabilization effect of backbone substitutions of N-heterocyclic carbene. Alkenes 0-6 high mobility group nucleosomal binding domain 4 Homo sapiens 78-100 20336192-2 2008 The key steps are a 5-exo-trig cyclization of a zinc enolate on an unactivated alkene and a stereocontrolled alkylation of the enolate formed from 3S-methyl-pyrrolidine-1,2R-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester. Alkenes 79-85 mediator complex subunit 25 Homo sapiens 187-193 18500801-1 2008 Rat NADP-dependent leukotriene B4 12-hydroxydehydrogenase (Ltb4dh) catalyzes olefin reductions for some activated alkenes at the expense of NADPH in the absence of a flavin cofactor. Alkenes 77-83 prostaglandin reductase 1 Rattus norvegicus 4-57 18624394-9 2008 For hydrogenation of olefins, the efficiency (turnover frequency, TOF) and stability (turnover number, TON) depend on the size of the dendrimer-encapsulated PdNP catalysts, similar to the behavior of polymer-supported PdNP catalysts, suggesting a classic mechanism in which all of the steps proceed on the PdNP surface. Alkenes 21-28 FEZ family zinc finger 2 Homo sapiens 66-69 18500801-1 2008 Rat NADP-dependent leukotriene B4 12-hydroxydehydrogenase (Ltb4dh) catalyzes olefin reductions for some activated alkenes at the expense of NADPH in the absence of a flavin cofactor. Alkenes 77-83 prostaglandin reductase 1 Rattus norvegicus 59-65 18500801-1 2008 Rat NADP-dependent leukotriene B4 12-hydroxydehydrogenase (Ltb4dh) catalyzes olefin reductions for some activated alkenes at the expense of NADPH in the absence of a flavin cofactor. Alkenes 114-121 prostaglandin reductase 1 Rattus norvegicus 4-57 18500801-1 2008 Rat NADP-dependent leukotriene B4 12-hydroxydehydrogenase (Ltb4dh) catalyzes olefin reductions for some activated alkenes at the expense of NADPH in the absence of a flavin cofactor. Alkenes 114-121 prostaglandin reductase 1 Rattus norvegicus 59-65 18393413-1 2008 We report the first measured activation parameters for the additions of CCl2 and CClF to simple alkenes and demonstrate the existence of enthalpic barriers for CCl2 additions to cyclohexene and 1-hexene. Alkenes 96-103 C-C motif chemokine ligand 2 Homo sapiens 72-76 18459808-1 2008 Treatment of alkenes with NBS, a nitrile, NaHCO3 and water in the presence of Cu(OTf)2 or Zn(OTf)2 is reported to furnish oxazolines in one pot and good yields. Alkenes 13-20 nibrin Homo sapiens 26-29 18459808-1 2008 Treatment of alkenes with NBS, a nitrile, NaHCO3 and water in the presence of Cu(OTf)2 or Zn(OTf)2 is reported to furnish oxazolines in one pot and good yields. Alkenes 13-20 POU class 2 homeobox 2 Homo sapiens 78-86 18443703-1 2008 A meso-palladioporphyrin intermediate was isolated from a Heck reaction between an iodoporphyrin and a non-activated olefin using a Pd(PPh3)2Cl2/Et3N system; its structure was characterized by NMR, MS and X-ray crystallography. Alkenes 117-123 caveolin 1 Homo sapiens 135-139 18370384-7 2008 In conjunction with previous surface science studies of EpB chemistry, these results can help explain selectivity trends for reactions of EpB on Pt catalysts and bimetallic PtAg catalysts, with indications that the enhanced olefin hydrogenation selectivity of PtAg catalysts likely originates from a bifunctional effect. Alkenes 224-230 rhomboid domain containing 3 Homo sapiens 173-177 18370384-7 2008 In conjunction with previous surface science studies of EpB chemistry, these results can help explain selectivity trends for reactions of EpB on Pt catalysts and bimetallic PtAg catalysts, with indications that the enhanced olefin hydrogenation selectivity of PtAg catalysts likely originates from a bifunctional effect. Alkenes 224-230 rhomboid domain containing 3 Homo sapiens 260-264 18219426-0 2008 Aminobromination of olefins with TsNH(2) and NBS as the nitrogen and bromine sources mediated by hypervalent iodine in a ball mill. Alkenes 20-27 nibrin Homo sapiens 45-48 18572597-3 2008 K/GCNF intercalates act as radical-anion alkene polymerization catalysts and reduce water with stoichiometric formation of hydrogen gas. Alkenes 41-47 nuclear receptor subfamily 6 group A member 1 Homo sapiens 2-6 18924190-1 2008 Enantioselective allylic alkylation with an organomagnesium reagent catalyzed by copper thiophene carboxylate (CuTC) was carried out on difunctionalized substrates, such as commercially available 1,4-dichloro-2-butene and 1,4-dibromo-2-butene, and on similar compounds of higher substitution pattern of the olefin for the formation of all-carbon chiral quaternary centers. Alkenes 307-313 cutC copper transporter Homo sapiens 111-115 18177039-5 2008 A simple FMO approach for alkene epoxidation is helpful to conceive a likely rationale for the greater oxidizing power of TFDO as compared to DDO. Alkenes 26-32 D-aspartate oxidase Homo sapiens 142-145 18092798-2 2008 Either the syn or the anti diastereomer can be prepared by choosing the appropriate alkene stereoisomer of the hydrazone. Alkenes 84-90 synemin Homo sapiens 11-14 18032035-4 2008 Derivatives of amylin(20-29) containing the alkene dipeptidosulfonamide isostere as well as the alkene dipeptide isostere were successfully synthesized using the solid phase cross metathesis method. Alkenes 44-50 islet amyloid polypeptide Homo sapiens 15-21 18032035-4 2008 Derivatives of amylin(20-29) containing the alkene dipeptidosulfonamide isostere as well as the alkene dipeptide isostere were successfully synthesized using the solid phase cross metathesis method. Alkenes 96-102 islet amyloid polypeptide Homo sapiens 15-21 18069987-1 2008 An efficient diamination reaction of alkenes has been developed for the synthesis of bromoalkyl-branched imidazolines by using CuI-PPh3 as the catalyst and N,N-dibromo-p-toluenesulfonamide as the nitrogen/halogen sources. Alkenes 37-44 protein phosphatase 4 catalytic subunit Homo sapiens 131-135 18437248-2 2008 The Rh(II)-catalyzed reaction also takes place intramolecularly to give products derived from trapping of the carbonyl ylide dipole with a tethered alkene. Alkenes 148-154 Rh blood group D antigen Homo sapiens 4-9 18032035-0 2008 Delayed fibril formation of amylin(20-29) by incorporation of alkene dipeptidosulfonamide isosteres obtained by solid phase olefin cross metathesis. Alkenes 62-68 islet amyloid polypeptide Homo sapiens 28-34 18032035-0 2008 Delayed fibril formation of amylin(20-29) by incorporation of alkene dipeptidosulfonamide isosteres obtained by solid phase olefin cross metathesis. Alkenes 124-130 islet amyloid polypeptide Homo sapiens 28-34 17948992-1 2007 An oligometallic template effect was observed on the cis/trans selectivity of a 32-membered macrocyclic tetraoxime in ring-closing olefin metathesis of an acyclic diallyl derivative H4L; the metathesis of heterotrinuclear complex LZn2M (M=Ca2+, La3+) afforded the cis isomer, whereas uncomplexed H4L gave the trans isomer. Alkenes 131-137 H4 clustered histone 7 Homo sapiens 182-185 19122758-4 2008 Good diastereoselectivities are obtained for the conversion of substrates bearing allylic substituents to 4,5-disubstituted imidazolidin-2-ones, and excellent selectivity for the generation of products resulting from syn-addition across the alkene is observed when substrates derived from cyclic alkenes or E-1,2-disubstituted alkenes are employed. Alkenes 241-247 synemin Homo sapiens 217-220 19122872-1 2008 Lewis acid activation of allyl halides utilizing Bi(OTf)(3) resulted in cationic cyclization of alkenes with high efficiency. Alkenes 96-103 POU class 5 homeobox 1 Homo sapiens 49-58 17960927-3 2007 The introduction of hydrophobic aromatic head groups, including quinolyl and benzoyl derivatives, and of alkenes as linkers led to several strongly active antibacterial compounds with MIC for Staphylococcus aureus, both methicillin-sensitive and -resistant strains, in the range of 0.1-5 microg mL-1, which is comparable to many established antibacterial agents. Alkenes 105-112 L1 cell adhesion molecule Mus musculus 295-299 17948992-1 2007 An oligometallic template effect was observed on the cis/trans selectivity of a 32-membered macrocyclic tetraoxime in ring-closing olefin metathesis of an acyclic diallyl derivative H4L; the metathesis of heterotrinuclear complex LZn2M (M=Ca2+, La3+) afforded the cis isomer, whereas uncomplexed H4L gave the trans isomer. Alkenes 131-137 H4 clustered histone 7 Homo sapiens 296-299 17803310-3 2007 Depending on the alkene geometry of the starting material either diastereomer, anti or syn, is accessible with good levels of acyclic stereocontrol. Alkenes 17-23 synemin Homo sapiens 87-90 24019585-0 2007 Chemistry of a novel zerovalent ruthenium pi-acidic alkene complex, Ru (eta (6)-1,3,5-cyclooctatriene)(eta (2)-dimethyl fumarate)2. Alkenes 52-58 endothelin receptor type A Homo sapiens 72-75 17434493-1 2007 Aminoacylase III (AAIII) plays an important role in deacetylation of acetylated amino acids and N-acetylated S-cysteine conjugates of halogenated alkenes and alkanes. Alkenes 146-153 aspartoacylase (aminoacylase) 3 Mus musculus 0-16 17434493-1 2007 Aminoacylase III (AAIII) plays an important role in deacetylation of acetylated amino acids and N-acetylated S-cysteine conjugates of halogenated alkenes and alkanes. Alkenes 146-153 aspartoacylase (aminoacylase) 3 Mus musculus 18-23 24019585-0 2007 Chemistry of a novel zerovalent ruthenium pi-acidic alkene complex, Ru (eta (6)-1,3,5-cyclooctatriene)(eta (2)-dimethyl fumarate)2. Alkenes 52-58 endothelin receptor type A Homo sapiens 103-106 17084061-8 2007 Dithiothreitol, a hydrophobic SH-reducing agent, was able to restore and to protect delta-ALA-D activity inhibited by tris-selenide alkene derivatives. Alkenes 132-138 aminolevulinate dehydratase Homo sapiens 84-95 17375917-0 2007 Mu-eta1:eta1-peroxo-bridged dinuclear peroxotungstate catalytically active for epoxidation of olefins. Alkenes 94-101 secreted phosphoprotein 1 Homo sapiens 3-7 17375917-0 2007 Mu-eta1:eta1-peroxo-bridged dinuclear peroxotungstate catalytically active for epoxidation of olefins. Alkenes 94-101 secreted phosphoprotein 1 Homo sapiens 8-12 17339993-0 2007 On the mechanism of the Rh(II)-catalysed cyclopropanation of alkenes. Alkenes 61-68 Rh blood group D antigen Homo sapiens 24-29 17298042-7 2007 An important section is devoted to the rigorous experimental validation of the SAR predictions against direct measurements of the site-specific addition contributions within the alkene, for monoalkenes as well as conjugated alkenes. Alkenes 178-184 sarcosine dehydrogenase Homo sapiens 79-82 17319670-9 2007 Cluster 2 also is a catalyst or catalyst precursor for the isomerization of olefins, namely, hex-1-ene to cis-hex-2-ene and tetramethyl allene to 2,4-dimethylpenta-1,3-diene. Alkenes 76-83 exonuclease 1 Homo sapiens 93-98 17295468-2 2007 Five group 13 alkene analogues, ArX=XAr, where X = B, Al, Ga, In, and Tl, have been chosen as model reactants in this work. Alkenes 14-20 aristaless related homeobox Homo sapiens 32-35 17298042-7 2007 An important section is devoted to the rigorous experimental validation of the SAR predictions against direct measurements of the site-specific addition contributions within the alkene, for monoalkenes as well as conjugated alkenes. Alkenes 194-201 sarcosine dehydrogenase Homo sapiens 79-82 17348852-6 2007 The alkene compounds were also shown to have binding affinity for the estrogen receptor alpha (IC50 values for the most active compounds in the range 0.110-0.293 microM) together with selectivity for ER alpha/beta. Alkenes 4-10 estrogen receptor 1 Homo sapiens 70-93 17348852-6 2007 The alkene compounds were also shown to have binding affinity for the estrogen receptor alpha (IC50 values for the most active compounds in the range 0.110-0.293 microM) together with selectivity for ER alpha/beta. Alkenes 4-10 estrogen receptor 1 Homo sapiens 200-208 17431865-0 2007 Asymmetric bioreduction of activated alkenes using cloned 12-oxophytodienoate reductase isoenzymes OPR-1 and OPR-3 from Lycopersicon esculentum (tomato): a striking change of stereoselectivity. Alkenes 37-44 12-oxophytodienoate reductase 1 Solanum lycopersicum 99-114 17263391-1 2007 In the presence of the third generation Grubbs catalyst, the ring-expanding olefin metathesis of a monocyclooct-4-en-1-yl functionalized salen ligand and the corresponding Co(II)(salen) complex at low monomer concentrations results in the exclusive formation of macrocyclic oligomeric structures with the salen moieties being attached in an unsymmetrical, flexible, pendent manner. Alkenes 76-82 mitochondrially encoded cytochrome c oxidase II Homo sapiens 172-178 17221975-2 2007 For 1,1,2-trisubstituted epoxyalkynes, this Co2(CO)6-allene species reacted with a tethered olefin to give [2+2]-cycloadducts, and with CO and a tethered olefin to produce [2+2+1]-cycloadducts. Alkenes 92-98 complement C2 Homo sapiens 44-47 17221975-2 2007 For 1,1,2-trisubstituted epoxyalkynes, this Co2(CO)6-allene species reacted with a tethered olefin to give [2+2]-cycloadducts, and with CO and a tethered olefin to produce [2+2+1]-cycloadducts. Alkenes 154-160 complement C2 Homo sapiens 44-47 17132008-3 2006 A deuterium-labeling experiment indicates that the oxidative addition proceeds via SN2-type attack of palladium(0) on the less-hindered carbon of the aziridine ring and that alkene insertion occurs in a syn fashion. Alkenes 174-180 synemin Homo sapiens 203-206 17216632-0 2007 Fmoc-based solid-phase synthesis of GPR54-agonistic pentapeptide derivatives containing alkene- and fluoroalkene-dipeptide isosteres. Alkenes 88-94 KISS1 receptor Homo sapiens 36-41 17107070-2 2006 Key intermediates are azabicycloalkenes such as 1 and 2, which are acylated with unsaturated carboxylic acids and subsequently submitted to tandem olefin metathesis. Alkenes 147-153 prostaglandin D2 receptor Homo sapiens 45-55 16890271-1 2006 Reactions of alkenes with OH, NO3 and O3. Alkenes 13-20 NBL1, DAN family BMP antagonist Homo sapiens 30-33 16871511-5 2006 As reported previously, the catalytic behavior of cis-alpha and cis-beta isomers of [Fe(bpmcn)(OTf)2] with respect to olefin oxidation depends dramatically on the geometry adopted by the iron complex. Alkenes 118-124 POU class 2 homeobox 2 Homo sapiens 95-100 16952251-2 2006 GaN(0001) surfaces exposed to a hydrogen plasma will react with organic molecules bearing an alkene (C=C) group when illuminated with 254 nm light. Alkenes 93-99 gigaxonin Homo sapiens 0-3 16878953-0 2006 Synthesis, structures, and olefin polymerization capability of vanadium(4+) imido compounds with fac-N3 donor ligands. Alkenes 27-33 FA complementation group C Homo sapiens 97-100 16922539-4 2006 The water solubility of cucurbit[8]uril is enhanced by inclusion of water soluble cinnamic acids and positions the olefins in an arrangement that favors the formation of syn head-head cyclobutanes in near quantitative yields. Alkenes 115-122 synemin Homo sapiens 170-173 16755620-1 2006 Three pathways actually compete in metal-catalyzed cyclizations of enynes in which the metal selectively activates the alkyne: an endocyclic process and two exo-cyclizations, one proceeding by anti attack of the alkene and a second one resulting in a syn addition. Alkenes 212-218 synemin Homo sapiens 251-254 16930051-2 2006 According to B3LYP/6-311+G(d,p) computations, the corresponding carbene endo-7 easily produces the highly strained neutral C8H8 compound 4 comprising a pyramidally tetracoordinated carbon which then rearranges to bridgehead alkene 15 through a cascade of rearrangements. Alkenes 224-230 mannosidase endo-alpha Homo sapiens 72-76 16930053-2 2006 The reaction of allyl carbamates with activated olefins in the presence of Pd(PPh3)4 catalyst in THF proceeded smoothly at room temperature to give the corresponding beta,alpha-bisadducts, beta-amino-alpha-allylated products, in high yields. Alkenes 48-55 caveolin 1 Homo sapiens 78-82 16741907-7 2006 A plausible catalytic cycle for the Al(OTf)(3)-catalyzed intramolecular hydroalkoxylation of unactivated olefins is proposed. Alkenes 105-112 POU class 5 homeobox 1 Homo sapiens 36-45 16846239-10 2006 PLP-dependent mitochondrial aspartate aminotransferase (mitAspAT) is a mitochondrial enzyme that catalyzes beta-elimination reactions with cysteine S-conjugates of halogenated alkenes. Alkenes 176-183 glutamatic-oxaloacetic transaminase 2, mitochondrial Mus musculus 14-54 16804582-3 2006 In the presence of K2CO3 and activated olefins (ol = dmfu, fn), the latter compounds react with an excess of 4-R2C6H4B(OH)2 (R2= H, Me, OMe, Cl) to give [Pd(eta2-ol)(P-N)] and the corresponding biaryl through transmetallation and fast reductive elimination. Alkenes 39-46 DNA polymerase iota Homo sapiens 157-161 16768499-6 2006 The counteranions, such as NO3- were found to interact strongly with surface silanols through multiple hydrogen bonds but have limited effect on the adsorption energy of olefins on the Ag+ cations. Alkenes 170-177 NBL1, DAN family BMP antagonist Homo sapiens 27-30 16431113-0 2006 Fragment-based drug discovery of carbonic anhydrase II inhibitors by dynamic combinatorial chemistry utilizing alkene cross metathesis. Alkenes 111-117 carbonic anhydrase 2 Bos taurus 33-54 16756288-1 2006 The combination of the air-stable RuIII complex [Cp*RuCl2(PPh3)] with AIBN can be used to catalyze the atom transfer radical addition reactions of polychlorinated compounds and of sulfonyl chlorides to olefins with unprecedented turnover numbers of up to 44 000. Alkenes 202-209 caveolin 1 Homo sapiens 58-62 16737275-1 2006 The barriers to internal rotation of methylated, ethynylated, and vinylated butatrienes and alkenes were calculated at the CASPT2/6-31G(d)//B3LYP/6-31G(d) level. Alkenes 92-99 protein tyrosine phosphatase non-receptor type 22 Homo sapiens 142-145 16768404-0 2006 Reversibility of structural transition of cytochrome c on interacting with and releasing from alternating copolymers of maleic Acid and alkene. Alkenes 136-142 cytochrome c, somatic Homo sapiens 42-54 16608324-0 2006 Gyroscope-like molecules consisting of PdX2/PtX2 rotators encased in three-spoke stators: synthesis via alkene metathesis, and facile substitution and demetalation. Alkenes 104-110 paired like homeodomain 2 Homo sapiens 44-48 16673036-2 2006 Density functional calculations are reported concerning the olefin metathesis characteristics of a variety of P-heterocyclic carbene (PHC) complexes. Alkenes 60-66 solute carrier family 25 member 3 Homo sapiens 110-138 16268627-4 2005 These studies demonstrate the validity of our synthetic strategy, although they reveal some problems associated with the olefin cross metathesis, whose efficiency depends on the substituent at the C-2 position as well as the steric environment of the alkene. Alkenes 121-127 complement C2 Homo sapiens 197-200 16557329-9 2006 Semi-hydrogenation of the resulting epoxide 36 followed by dihydroxylation of the alkene effected concomitant cyclization, thus completing the synthesis of the ABC spiroacetal ring fragment 6. Alkenes 82-88 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 160-163 16506768-6 2006 Evidence is presented that suggests the syn-addition products derive from an unprecedented transannular alkene insertion of an 11-membered Pd(Ar)(OR) complex. Alkenes 104-110 synemin Homo sapiens 40-43 16360644-7 2006 Modifications of the exocyclic alkene of EqM substantially reduce EqM"s ability to inhibit NF-kappaB activation. Alkenes 31-37 nuclear factor kappa B subunit 1 Homo sapiens 91-100 16494329-1 2006 By means of density functional theory (B3LYP/6-31G*) coupled with effective cluster models, we predict that the well-known cycloaddition reactions of carbenes and nitrenes to alkenes in organic chemistry can be employed as a new type of surface reaction to organically functionalize the Si (100) and Ge (100) surfaces at low temperature. Alkenes 175-182 protein tyrosine phosphatase non-receptor type 22 Homo sapiens 41-44 16471857-13 2006 The activation barrier of the RDS (epoxidation step: DeltaE(act) = 19.6 kcal/mol) is in the same range as that in the published computationally investigated olefin epoxidation mechanisms involving Ti sites (without Au involved) indicating that isolated Au clusters and possibly Au clusters on non-Ti supports can be active for gas-phase partial oxidation, even though cooperative mechanisms involving Au clusters/Ti-based-supports may be favored. Alkenes 157-163 peripherin 2 Homo sapiens 30-33 16358352-5 2006 Two different cyclopropanation pathways have been found; they depend on the structures of the cyclopropyl gold carbenes (anti or syn) and the relative arrangements of the metal carbenes and the alkenes. Alkenes 194-201 synemin Homo sapiens 129-132 16223684-1 2006 Rapid, efficient and selective alkene epoxidation and alkane hydroxylation with sodium periodate catalyzed by Mn (TPyP) supported on chloromethylated polystyrene, [Mn(TPyP)-CMP], under ultrasonic irradiation were reported. Alkenes 31-37 matrilin 1 Homo sapiens 173-176 16352467-3 2005 Here, we describe the synthesis of a novel F-12509A olefin isomer, K1, as an effective CERK inhibitor. Alkenes 52-58 ceramide kinase Rattus norvegicus 87-91 16323842-0 2005 A highly pyramidalized cage alkene formed via the double Diels-Alder cycloaddition of syn-4,5,13,14-bis(dehydro)octafluoroparacyclophane to anthracene. Alkenes 28-34 syntrophin gamma 1 Homo sapiens 86-91 16262334-0 2005 Interactions of apo cytochrome C with alternating copolymers of maleic acid and alkene. Alkenes 80-86 cytochrome c, somatic Homo sapiens 20-32 16526637-7 2006 This is different from gas-phase alkene-NO3 reactions, in which a large fraction of the products are formed through these pathways. Alkenes 33-39 NBL1, DAN family BMP antagonist Homo sapiens 40-43 16506751-2 2006 Electron-deficient alkenes, p-X-trans-beta-nitrostyrene (X = OCH3, CH3, H, F, Br, CF3, NO2), react quantitatively with (bc)Pd(eta2-O2) (bc = bathocuproine) in dichloromethane at room temperature to form the corresponding palladium(0)-alkene complexes. Alkenes 19-26 DNA polymerase iota Homo sapiens 126-133 16448104-2 2006 Catalytic activity has been observed for olefins CH2C(H)(X) with X = CN, C(O)Me, or CO2Me as well as crotononitrile. Alkenes 41-48 complement C2 Homo sapiens 84-87 16302169-4 2006 Ligands designed for Pin1 and CyP have primarily been ground state analogues: alkenes and bicyclic compounds. Alkenes 78-85 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Homo sapiens 21-25 16302169-4 2006 Ligands designed for Pin1 and CyP have primarily been ground state analogues: alkenes and bicyclic compounds. Alkenes 78-85 peptidylprolyl isomerase G Homo sapiens 30-33 16354078-0 2005 Photoinduced metalation of nonactivated C-Cl bonds with samarium diiodide: synthesis of alkenes with high (Z)-selectivity through beta-elimination reactions. Alkenes 88-95 crystallin gamma C Homo sapiens 40-44 16076182-1 2005 A new method for intermolecular sp3-sp3 C-C bond formation between primary aliphatic alcohol and olefin by use of a RhCl(PPh3)3 (cat. Alkenes 97-103 Sp3 transcription factor Homo sapiens 32-35 16295274-9 2005 Both alkanes and alkene/dienes came from tank farm and naphtha cracking units and were mainly composed of C3-C5 members. Alkenes 17-23 ADAM metallopeptidase with thrombospondin type 1 motif 1 Homo sapiens 106-111 16235960-1 2005 [reaction: see text] LiBr catalyzes efficiently the dihydroxylation of alkenes to afford syn and anti diols with excellent diastereoselectivity depending upon the use of NaIO(4) (30 mol %) or PhI(OAc)(2) (1 equiv), respectively, as the oxidants. Alkenes 71-78 synemin Homo sapiens 89-92 16172673-1 2005 Ranging from the oxidative conversion of water to O(2) to the elegant hydroxylation of olefins and to oxidative dehydrogenation of alcohols Ru-mediated oxidations are finding increasing application due to the unique properties of this extremely versatile transition metal, whose oxidation state can vary from -II to +VIII. Alkenes 87-94 cytochrome c oxidase subunit 8A Homo sapiens 317-321 16013029-4 2005 The organized Zn2(ImP)2 bearing allyl side chains was covalently linked by ring-closing olefin metathesis catalyzed with Grubbs catalyst. Alkenes 88-94 insulin like growth factor 2 mRNA binding protein 2 Homo sapiens 14-23 16146389-3 2005 Sharpless asymmetric dihydroxylation was utilized for regioselective functionalization of a styrene-derived alkene, in the presence of the C13-C15 diene functionality. Alkenes 108-114 homeobox C13 Homo sapiens 139-142 16146389-3 2005 Sharpless asymmetric dihydroxylation was utilized for regioselective functionalization of a styrene-derived alkene, in the presence of the C13-C15 diene functionality. Alkenes 108-114 placenta associated 8 Homo sapiens 143-146 16076182-1 2005 A new method for intermolecular sp3-sp3 C-C bond formation between primary aliphatic alcohol and olefin by use of a RhCl(PPh3)3 (cat. Alkenes 97-103 Sp3 transcription factor Homo sapiens 36-39 16833976-5 2005 Using the spin philicity concept, the regioselectivity can almost be completely interpreted as resulting from the interaction of the site on the alkene with the highest spin philicity (i.e., lowest destabilization upon increasing spin number) with the site showing the highest change of spin number on the enone expected to result in the largest stabilization of this species. Alkenes 145-151 spindlin 1 Homo sapiens 169-173 15997293-1 2005 Allylic amines (as their protonated ammonium salts) can be epoxidised with high syn diastereoselectivity and regioselectivity at the proximal alkene in substrates with several double bonds using Oxone. Alkenes 142-148 synemin Homo sapiens 80-83 16833976-0 2005 Spin-polarized conceptual density functional theory study of the regioselectivity in the [2+2] photocycloaddition of enones to substituted alkenes. Alkenes 139-146 spindlin 1 Homo sapiens 0-4 16010370-2 2005 The use of bis(2,2,2-trichloroethyl)azodicarboxylate as the amination reagent and Cu(OTf)(2) and Yb(OTf)(3) as the catalysts gave the aza-ene reaction of different alkenes, leading to the corresponding allyl amines in high yields. Alkenes 164-171 POU class 5 homeobox 1 Homo sapiens 97-106 16833976-5 2005 Using the spin philicity concept, the regioselectivity can almost be completely interpreted as resulting from the interaction of the site on the alkene with the highest spin philicity (i.e., lowest destabilization upon increasing spin number) with the site showing the highest change of spin number on the enone expected to result in the largest stabilization of this species. Alkenes 145-151 spindlin 1 Homo sapiens 10-14 16833976-5 2005 Using the spin philicity concept, the regioselectivity can almost be completely interpreted as resulting from the interaction of the site on the alkene with the highest spin philicity (i.e., lowest destabilization upon increasing spin number) with the site showing the highest change of spin number on the enone expected to result in the largest stabilization of this species. Alkenes 145-151 spindlin 1 Homo sapiens 169-173 16833976-5 2005 Using the spin philicity concept, the regioselectivity can almost be completely interpreted as resulting from the interaction of the site on the alkene with the highest spin philicity (i.e., lowest destabilization upon increasing spin number) with the site showing the highest change of spin number on the enone expected to result in the largest stabilization of this species. Alkenes 145-151 spindlin 1 Homo sapiens 169-173 16010370-1 2005 Lewis acids such as Cu(OTf)(2), Zn(OTf)(2), Yb(OTf)(3) and Nd(OTf)(3) catalyze the aza-ene reaction of alkenes with azodicarboxylates, giving the allylic amination adducts. Alkenes 103-110 POU class 5 homeobox 1 Homo sapiens 44-53 15962036-6 2005 Atmospheric lifetimes were calculated with respect to important oxidants in the troposphere for the alkenes studied, and NO3-initiated oxidation is found to be the dominant degradation route for (Z)-pent-2-ene, (Z)-hex-3-ene and (E)-3-methylpent-2-ene. Alkenes 100-107 NBL1, DAN family BMP antagonist Homo sapiens 121-124 15917935-1 2005 A first example of an enantioselective catalytic diamination of olefins has been developed which employs enantiopure titanium complexes as catalysts and bis(tbutylimido)dioxoosmium(VIII) as nitrogen source. Alkenes 64-71 cytochrome c oxidase subunit 8A Homo sapiens 181-185 15941315-3 2005 Twenty-one compounds, including 11 aldehydes, three alcohols, four ketones, one furan, one alkane, and one alkene were detected in the LOX normal soybean line. Alkenes 107-113 linoleate 9S-lipoxygenase-4 Glycine max 135-138 15907122-1 2005 Crystal structures of Os(IV) derivatives and the reactivity and catalytic cyclopropanation of alkenes with EDA. Alkenes 94-101 ectodysplasin A Homo sapiens 107-110 16833827-1 2005 cis-2,3-Dimethylaziridine reacts with difluoroamine to give the corresponding alkene and nitrogen with retention of configuration. Alkenes 78-84 suppressor of cytokine signaling 2 Homo sapiens 0-5 15876029-0 2005 Intramolecular hydroamination of unactived olefins with Ti(NMe2)4 as a precatalyst. Alkenes 43-50 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens 59-63 16833761-0 2005 Products and mechanism of secondary organic aerosol formation from reactions of linear alkenes with NO3 radicals. Alkenes 87-94 NBL1, DAN family BMP antagonist Homo sapiens 100-103 16028720-3 2005 The FA olefin (Z, C-9/C-10) of 2 was hydrogenated to produce a derivative possessing a hydroxy function (C-12) on a saturated C18 FA chain. Alkenes 7-13 complement C9 Homo sapiens 18-21 16028720-3 2005 The FA olefin (Z, C-9/C-10) of 2 was hydrogenated to produce a derivative possessing a hydroxy function (C-12) on a saturated C18 FA chain. Alkenes 7-13 homeobox C10 Homo sapiens 22-26 16028720-3 2005 The FA olefin (Z, C-9/C-10) of 2 was hydrogenated to produce a derivative possessing a hydroxy function (C-12) on a saturated C18 FA chain. Alkenes 7-13 Bardet-Biedl syndrome 9 Homo sapiens 126-129 15730330-3 2005 DFT calculations [B3LYP/6-31G(d)] on compound 20 gave important parameters of this pyramidalized alkene, such as the pyramidalization angle (61.7 degrees), the strain energy (72.9 kcal/mol), and the HOMO/LUMO gap (3.79 eV). Alkenes 97-103 protein tyrosine phosphatase non-receptor type 22 Homo sapiens 20-23 15701021-1 2005 The reactions of a series of Pd(II) methyl compounds of general formula LPd(NCCH(3))CH(3), where L is a bulky phenoxydiazene or phenoxyaldimine ligand with the polar olefin acrylonitrile (AN), are reported. Alkenes 166-172 acyl-CoA synthetase bubblegum family member 1 Homo sapiens 72-75 15704886-2 2005 Excitation of such templated olefins results in syn head-head cyclobutanes in nearly quantitative yields. Alkenes 29-36 synemin Homo sapiens 48-51 15598562-6 2005 Structure-activity data acquired indicate that an olefin having either a C-1 p-MeSO2NH-phenyl, or a p-N3-phenyl, substituent, that is, cis to a C-2 unsubstituted phenyl substituent, in conjunction with C-1 unsubstituted phenyl and C-2 alkyl substituents, provides a novel template to design acyclic olefinic COX-2 inhibitors. Alkenes 50-56 heterogeneous nuclear ribonucleoprotein C Homo sapiens 73-78 15598562-6 2005 Structure-activity data acquired indicate that an olefin having either a C-1 p-MeSO2NH-phenyl, or a p-N3-phenyl, substituent, that is, cis to a C-2 unsubstituted phenyl substituent, in conjunction with C-1 unsubstituted phenyl and C-2 alkyl substituents, provides a novel template to design acyclic olefinic COX-2 inhibitors. Alkenes 50-56 heterogeneous nuclear ribonucleoprotein C Homo sapiens 73-76 15598562-6 2005 Structure-activity data acquired indicate that an olefin having either a C-1 p-MeSO2NH-phenyl, or a p-N3-phenyl, substituent, that is, cis to a C-2 unsubstituted phenyl substituent, in conjunction with C-1 unsubstituted phenyl and C-2 alkyl substituents, provides a novel template to design acyclic olefinic COX-2 inhibitors. Alkenes 50-56 prostaglandin-endoperoxide synthase 2 Homo sapiens 308-313 15880636-2 2005 Ionized halothane (M+*) reacts with neutral halothane to form the ionized olefin [ClBrC=CF2]+*. Alkenes 74-80 ATPase H+ transporting accessory protein 1 Homo sapiens 88-91 15624930-1 2005 In the competitive peroxidation of mixtures of two alkenes with Co(II)/O(2)/Et(3)SiH, it was found that the relative reactivities of the alkene substrates are influenced by three major factors:. Alkenes 51-57 mitochondrially encoded cytochrome c oxidase II Homo sapiens 64-70 15575661-1 2004 [reaction: see text] The reaction of the imine of aromatic ketones with functionalized alkenes was performed under a catalytic amount of (PPh3)3RhCl, and corresponding ortho-alkylated ketones were obtained after hydrolysis. Alkenes 87-94 caveolin 1 Homo sapiens 138-142 15612732-5 2004 In contrast to bis-cyclopentadienyl chemistry, the olefin adducts of the bis-indenyl zirconium sandwiches undergo preferential C-H activation to yield the corresponding allyl hydride compounds, although reaction with excess olefin proceeds through the eta(2)-olefin adduct, forming the corresponding zirconacyclopentane. Alkenes 51-57 DNA polymerase iota Homo sapiens 252-258 15612732-5 2004 In contrast to bis-cyclopentadienyl chemistry, the olefin adducts of the bis-indenyl zirconium sandwiches undergo preferential C-H activation to yield the corresponding allyl hydride compounds, although reaction with excess olefin proceeds through the eta(2)-olefin adduct, forming the corresponding zirconacyclopentane. Alkenes 224-230 DNA polymerase iota Homo sapiens 252-258 15584734-5 2004 The photocatalytic oxygenation of anthracenes and olefins is initiated by photoexcitation of Acr+-Mes, which results in formation of the electron-transfer state: Acr*-Mes*+, followed by electron transfer from anthracenes and olefins to the Mes*+ moiety together with electron transfer from the Acr* moiety to O2. Alkenes 50-57 acrosin Homo sapiens 93-96 15584734-5 2004 The photocatalytic oxygenation of anthracenes and olefins is initiated by photoexcitation of Acr+-Mes, which results in formation of the electron-transfer state: Acr*-Mes*+, followed by electron transfer from anthracenes and olefins to the Mes*+ moiety together with electron transfer from the Acr* moiety to O2. Alkenes 50-57 acrosin Homo sapiens 162-165 15584734-5 2004 The photocatalytic oxygenation of anthracenes and olefins is initiated by photoexcitation of Acr+-Mes, which results in formation of the electron-transfer state: Acr*-Mes*+, followed by electron transfer from anthracenes and olefins to the Mes*+ moiety together with electron transfer from the Acr* moiety to O2. Alkenes 50-57 acrosin Homo sapiens 162-165 15584734-5 2004 The photocatalytic oxygenation of anthracenes and olefins is initiated by photoexcitation of Acr+-Mes, which results in formation of the electron-transfer state: Acr*-Mes*+, followed by electron transfer from anthracenes and olefins to the Mes*+ moiety together with electron transfer from the Acr* moiety to O2. Alkenes 225-232 acrosin Homo sapiens 93-96 15584734-5 2004 The photocatalytic oxygenation of anthracenes and olefins is initiated by photoexcitation of Acr+-Mes, which results in formation of the electron-transfer state: Acr*-Mes*+, followed by electron transfer from anthracenes and olefins to the Mes*+ moiety together with electron transfer from the Acr* moiety to O2. Alkenes 225-232 acrosin Homo sapiens 162-165 15584734-5 2004 The photocatalytic oxygenation of anthracenes and olefins is initiated by photoexcitation of Acr+-Mes, which results in formation of the electron-transfer state: Acr*-Mes*+, followed by electron transfer from anthracenes and olefins to the Mes*+ moiety together with electron transfer from the Acr* moiety to O2. Alkenes 225-232 acrosin Homo sapiens 162-165 15584734-6 2004 The resulting anthracene and olefin radical cations undergo the radical coupling reactions with O2*- to produce the epidioxyanthracene (An-O2) and dioxetane, respectively. Alkenes 29-35 anoctamin 2 Homo sapiens 136-141 15584744-1 2004 The chemoselectivity of activation by a (PPh3)4Pd catalyst on a series of small, olefin-based compounds that were substituted with a variety of allylic and vinylic functional groups was studied. Alkenes 81-87 protein phosphatase 4 catalytic subunit Homo sapiens 41-45 15483709-0 2004 Palladium(II) complexes of new OPN phosphine ligands and their application in homogeneously catalysed reactions of CO with alkenes or alkynes. Alkenes 123-130 secreted phosphoprotein 1 Homo sapiens 31-34 15530098-12 2004 That these hydrogenations appear to proceed via well-defined olefin insertion steps into an Fe-H linkage is indicated by the reaction between trihydride 5 and ethylene, which cleanly produces the ethyl complex [PhBP(iPr)(3)]Fe(CH(2)CH(3)) (13) and an equivalent of ethane. Alkenes 61-67 hyaluronan binding protein 2 Homo sapiens 211-222 15524480-0 2004 Rh(II)-catalyzed enantioselective cyclopropanation of olefins with dimethyl malonate via in situ generated phenyliodonium ylide. Alkenes 54-61 Rh blood group D antigen Homo sapiens 0-6 15524480-1 2004 Olefins are cyclopropanated with dimethyl malonate (1a) iodosylbenzene (PhI=O) and a Rh(II) carboxylate catalyst via an in situ generated phenyliodonium ylide (1c). Alkenes 0-7 Rh blood group D antigen Homo sapiens 85-91 15496093-0 2004 Oxygen-promoted palladium(II) catalysis: facile C(sp2)-C(sp2) bond formation via cross-coupling of alkenylboronic compounds and olefins. Alkenes 128-135 Sp2 transcription factor Homo sapiens 48-53 15496093-0 2004 Oxygen-promoted palladium(II) catalysis: facile C(sp2)-C(sp2) bond formation via cross-coupling of alkenylboronic compounds and olefins. Alkenes 128-135 Sp2 transcription factor Homo sapiens 55-60 15489981-1 2004 Biphasic BMI[middle dot]PF(6)/toluene solvent is a remarkably suitable and clean medium for performing olefin metathesis with a new 2nd generation ionic liquid supported-ruthenium catalyst: high levels of recyclability and reusability combined with a high reactivity were obtained with a variety of di- or tri-substituted and/or oxygen-containing dienes, and very low residual ruthenium levels were detected (1 to 22 ppm) in the products. Alkenes 103-109 sperm associated antigen 17 Homo sapiens 24-29 15263946-1 2004 Synthesis of unprecedented gold alkene complexes, [Au(N,N)(alkene)][PF6]. Alkenes 32-38 sperm associated antigen 17 Homo sapiens 68-71 15469263-2 2004 Silver acetate successfully catalyzed the cycloaddition reaction of azlactones with alkenes, generating Delta1-pyrrolines in very good yields without isomerization to the Delta2-pyrrolines or decarboxylation. Alkenes 84-91 delta like non-canonical Notch ligand 1 Homo sapiens 104-110 15357621-2 2004 Intramolecular 1,3-dipolar nitrone cycloaddition reaction of d-glucose-derived precursors having olefin at C-3 and nitrone at C-5, C-1, or C-2 (in nor-series) furnished bisisoxazolidinospirocycles 4-7, 11, and 12 in good yields. Alkenes 97-103 complement C3 Homo sapiens 107-110 15222019-8 2004 The measurement of alkene and methylene infrared bands may provide a useful tool for detecting changes in PUFA balance in the human body. Alkenes 19-25 pumilio RNA binding family member 3 Homo sapiens 106-110 15387587-2 2004 Upon irradiation with a xenon lamp through Pyrex (hnu >300 nm), terminal alkenes (R-CH=CH2) and alkynes (R-C triple bond CH) undergo iodoperfluoroalkylation with perfluoroalkyl iodides (RF-I) regioselectively, providing R-CH(I)-CH2-RF and R-C(I)=CH-RF, respectively. Alkenes 76-83 ring finger protein 34 Homo sapiens 189-193 15387624-1 2004 Bromodifluorophenylsulfanylmethane has been demonstrated to be a highly versatile gem-difluoromethylene (CF2) building block via the reaction of difluorophenylsulfanylmethyl radical with olefins. Alkenes 187-194 ATPase H+ transporting accessory protein 1 Homo sapiens 105-108 15264821-2 2004 A novel chiral Rh(II) catalyst (1) is introduced for the [2 + 1]-cycloaddition of ethyl diazoacetate to terminal acetylenes and olefins with high enantioselectivity. Alkenes 128-135 Rh blood group D antigen Homo sapiens 15-21 15263946-3 2004 Gold alkene complexes [Au(bipyR)(eta2-alkene)][PF6] (bipyR = 6-alkyl-2,2"-bipyridine) have been obtained by reaction of gold(III) oxo complexes [Au2(bipyR)2(mu-O)2][PF6]2 with alkenes. Alkenes 176-183 sperm associated antigen 17 Homo sapiens 47-50 15177467-3 2004 Compounds 3a and 3c in which the phenyl ring was para substituted with F and Br and olefin with Z geometry, showed better inhibitory activity against RDP enzyme (IC50 = 5-6 nM). Alkenes 84-90 dipeptidase 1 Homo sapiens 150-153 15113661-4 2004 Their tensioactive properties were determined at 45 degrees C. Olefin metathesis was used to synthesize the two single-chain bolaforms from undec-10-enyl galactopyranosides; two pseudomacrocyclic bolaforms were prepared by grafting two carbamates at O-4 and O-4" sugar positions of the single-chain bolaforms. Alkenes 63-69 immunoglobulin kappa variable 1D-37 (non-functional) Homo sapiens 250-253 15176780-1 2004 [reaction: see text] Iron(III) porphyrin complexes Fe(Por)Cl are effective catalysts for aziridination of alkenes using bromamine-T as the nitrene source. Alkenes 106-113 cytochrome p450 oxidoreductase Homo sapiens 54-57 15113661-4 2004 Their tensioactive properties were determined at 45 degrees C. Olefin metathesis was used to synthesize the two single-chain bolaforms from undec-10-enyl galactopyranosides; two pseudomacrocyclic bolaforms were prepared by grafting two carbamates at O-4 and O-4" sugar positions of the single-chain bolaforms. Alkenes 63-69 immunoglobulin kappa variable 1D-37 (non-functional) Homo sapiens 258-261 15096061-4 2004 When phenyliodonium ylides are generated in the presence of Rh(II) catalysts and olefins, they react in situ to afford cyclopropanes. Alkenes 81-88 Rh blood group D antigen Homo sapiens 60-65 15146520-6 2004 In the presence of an alkene and parahydrogen, signals corresponding to binuclear complexes of the type [Rh(H)2(PPh3)2(mu-Cl)(2)(Rh)(PPh3)(alkene)] are detected. Alkenes 22-28 caveolin 1 Homo sapiens 112-116 15146520-6 2004 In the presence of an alkene and parahydrogen, signals corresponding to binuclear complexes of the type [Rh(H)2(PPh3)2(mu-Cl)(2)(Rh)(PPh3)(alkene)] are detected. Alkenes 22-28 caveolin 1 Homo sapiens 133-137 15146520-6 2004 In the presence of an alkene and parahydrogen, signals corresponding to binuclear complexes of the type [Rh(H)2(PPh3)2(mu-Cl)(2)(Rh)(PPh3)(alkene)] are detected. Alkenes 139-145 caveolin 1 Homo sapiens 112-116 15146520-6 2004 In the presence of an alkene and parahydrogen, signals corresponding to binuclear complexes of the type [Rh(H)2(PPh3)2(mu-Cl)(2)(Rh)(PPh3)(alkene)] are detected. Alkenes 139-145 caveolin 1 Homo sapiens 133-137 15128240-1 2004 We demonstrate that sterically bulky N,N"-disubstituted cyclic thiourea-Pd(0) complexes are air- and moisture-stable and highly active catalysts for palladium-catalyzed Heck reaction of aryl iodides and bromides with olefins (TONs up to 500000 for the reaction of PhI and methyl acrylate). Alkenes 217-224 glucose-6-phosphate isomerase Homo sapiens 264-267 15099060-5 2004 The key step, a [Cp*Ru(MeCN)3]PF6-catalyzed alkene-alkyne coupling, was used to form the 20-membered ring in the final step of the synthesis. Alkenes 44-50 sperm associated antigen 17 Homo sapiens 30-33 14737658-2 2004 The diene ester required for the macrocyclization reaction was assembled via DCC-mediated esterification of two suitable partners, each bearing a terminal alkene group. Alkenes 155-161 DCC netrin 1 receptor Homo sapiens 77-80 15025493-4 2004 After the formation of the ruthenium(VI)dioxo-2,5-dioxolane, the reaction proceeds with the addition of a second olefin to yield ruthenium(IV)-bis(2,5-dioxolane), which in turn becomes oxidized first to rutheniumoxo(VI)-bis(2,5-dioxolane) 6(Ru) and then to ruthenium(VIII)-dioxo-bis(2,5-dioxolane) 7(Ru). Alkenes 113-119 cytochrome c oxidase subunit 8A Homo sapiens 267-271 14961625-0 2004 Synthesis of the C16-C35 fragment of integramycin using olefin hydroesterification as a linchpin reaction. Alkenes 56-62 migration and invasion enhancer 1 Homo sapiens 21-24 12859250-0 2003 L-alanine-glyoxylate aminotransferase II of rat kidney and liver mitochondria possesses cysteine S-conjugate beta-lyase activity: a contributing factor to the nephrotoxicity/hepatotoxicity of halogenated alkenes? Alkenes 204-211 kynurenine aminotransferase 1 Rattus norvegicus 88-119 14627413-2 2003 Oxidative cleavage of the alkene leads to a Boc-protected amino acid with the configuration of naturally occurring amino acids (L). Alkenes 26-32 BOC cell adhesion associated, oncogene regulated Homo sapiens 44-47 14758758-3 2003 In the second part, applications of the hydroarylation of alkenes in the syntheses of epibatidine analogs, argemonine, retinoid X receptor (RXR), retinoic acid receptor (RAR) modulators and neurokinin (NK) receptor NK1 antagonists will be discussed. Alkenes 58-65 retinoid X receptor alpha Homo sapiens 119-138 14604356-1 2003 A new strategy for the facile synthesis of azabicyclo[m.n.1]alkenes (m = 3-5; n = 3, 2) has been developed that involves the ring-closing metathesis (RCM) reaction of cis-2,6-dialkenyl-N-acyl piperidine derivatives. Alkenes 60-67 suppressor of cytokine signaling 2 Homo sapiens 167-172 14758758-3 2003 In the second part, applications of the hydroarylation of alkenes in the syntheses of epibatidine analogs, argemonine, retinoid X receptor (RXR), retinoic acid receptor (RAR) modulators and neurokinin (NK) receptor NK1 antagonists will be discussed. Alkenes 58-65 retinoid X receptor alpha Homo sapiens 140-143 14758758-3 2003 In the second part, applications of the hydroarylation of alkenes in the syntheses of epibatidine analogs, argemonine, retinoid X receptor (RXR), retinoic acid receptor (RAR) modulators and neurokinin (NK) receptor NK1 antagonists will be discussed. Alkenes 58-65 tachykinin receptor 1 Homo sapiens 215-218 12952483-9 2003 Competition between direct atom transfer and ring expansion followed by diolate cycloreversion is demonstrated by reaction of 3 with excess cis-stilbene oxide and styrene oxide in the absence of reductant to give a 4:1 mixture of alkene and syn-diolate from cis-stilbene oxide or a 5.5:1 mixture of alkene and syn-diolate from styrene oxide under conditions where diolate cycloreversion is a negligible contributor. Alkenes 299-305 synemin Homo sapiens 241-244 14570453-2 2003 Catalyzed alkene isomerization affords allyl vinyl ethers from easily prepared di(allyl) ethers; direct thermolysis of these reaction mixtures leads to highly diastereoselective [3,3] sigmatropic rearrangements affording syn-2,3-dialkyl-4-pentenal derivatives. Alkenes 10-16 synapsin II Homo sapiens 221-226 14519449-4 2003 Analog A, which bears an alkene moiety between C-1 and C-14, a ketone at the C-2 position, and an alkyne moiety between C-3 and C-4, had the greatest anti-adhesive effect. Alkenes 25-31 heterogeneous nuclear ribonucleoprotein C Homo sapiens 47-59 14519449-5 2003 Change of the alkene between C-1 and C-14 to an alkane (analog I) decreased the anti-adhesive effect by 2.5-4 fold, while substitution of ketone by hydroxyl (analog G) at the C-2 position caused an 11-fold decrease in the anti-adhesive effect. Alkenes 14-20 heterogeneous nuclear ribonucleoprotein C Homo sapiens 29-41 14519449-6 2003 Substitution of the alkyne moiety between C-3 and C-4 by an alkene (B and E) or alkane (D) blocked completely the anti-adhesive effect. Alkenes 60-66 complement C3 Homo sapiens 42-45 14519449-6 2003 Substitution of the alkyne moiety between C-3 and C-4 by an alkene (B and E) or alkane (D) blocked completely the anti-adhesive effect. Alkenes 60-66 complement C4A (Rodgers blood group) Homo sapiens 50-53 14519449-8 2003 Change of the alkyne moiety between C-3 and C-4 to an alkene (B and E) or alkane (D) blocked completely these inhibitory effects of phomactin. Alkenes 54-60 complement C4A (Rodgers blood group) Homo sapiens 44-47 12688779-2 2003 Lewis acid-promoted carbonyl-ene reaction of enantiomerically pure 4-oxoazetidine-2-carbaldehydes with various activated alkenes gives 4-[(1"-hydroxy)homoallyl]-beta-lactams with a very high level of syn diastereofacial selectivity. Alkenes 121-128 synemin Homo sapiens 200-203 12914440-4 2003 On the other hand, complex 2, [(6-Me3-TPA)Fe(OTf)2], representative of Class B catalysts, prefers instead to oxidize electron-deficient olefins, suggesting an oxidant with nucleophilic character. Alkenes 136-143 POU class 2 homeobox 2 Homo sapiens 45-50 12868935-0 2003 Addition of carboxyalkyl radicals to alkenes through a catalytic process, using a Mn(II)/Co(II)/O2 redox system. Alkenes 37-44 mitochondrially encoded cytochrome c oxidase II Homo sapiens 89-95 12868935-1 2003 A novel strategy for production of mono- and dicarboxylic acids by the addition of carboxyalkyl radicals to alkenes and dienes, respectively, was successfully developed through a catalytic process with use of Mn(II)/Co(II)/O(2) system. Alkenes 108-115 mitochondrially encoded cytochrome c oxidase II Homo sapiens 216-222 12785828-3 2003 As a synthetic application, intramolecular cyclization of propargylic alcohols bearing an alkene moiety has been developed to give the corresponding syn-substituted chromanes in high yields with an excellent diastereoselectivity. Alkenes 90-96 synemin Homo sapiens 5-8 12633091-1 2003 [reaction: see text] A new synthetic procedure for aminohalogenation of olefins has been developed for the preparation of vicinal haloamine derivatives in high yields by using Cu, Mn, or V catalysts with p-toluenesulfonamide (TsNH(2)) and N-bromosuccinimide (NBS) as nitrogen and bromine sources, respectively. Alkenes 72-79 nibrin Homo sapiens 259-262 12643683-0 2003 Epoxidation of olefins by hydroperoxo-ferric cytochrome P450. Alkenes 15-22 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 56-60 12643683-4 2003 The present results provide strong evidence that hydroperoxo-ferric P450 can serve as a second electrophilic oxidant capable of olefin epoxidation. Alkenes 128-134 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 68-72 12633091-0 2003 Transition metal-catalyzed regio- and stereoselective aminobromination of olefins with TsNH2 and NBS as nitrogen and bromine sources. Alkenes 74-81 nibrin Homo sapiens 97-100 12669851-1 2003 The complex trans-[Rh(Cl)(CO)(PPh3)2] (1) is an efficient catalyst precursor for the dehydrogenative borylation of alkenes without consumption of half the alkene substrate by hydrogenation, giving useful vinylboronate esters including 1,1-disubstituted derviatives that cannot be made by alkyne hydroboration. Alkenes 115-122 caveolin 1 Homo sapiens 30-34 12669851-1 2003 The complex trans-[Rh(Cl)(CO)(PPh3)2] (1) is an efficient catalyst precursor for the dehydrogenative borylation of alkenes without consumption of half the alkene substrate by hydrogenation, giving useful vinylboronate esters including 1,1-disubstituted derviatives that cannot be made by alkyne hydroboration. Alkenes 115-121 caveolin 1 Homo sapiens 30-34 12580614-5 2003 Comparative reactivity studies for the catalase-like disproportionation of hydrogen peroxide and the epoxidation of olefins by the HPX and HPD platforms with acid and ester hanging groups reveal that the introduction of a proton-transfer network, properly oriented to a redox-active platform, can orchestrate catalytic O-O bond activation. Alkenes 116-123 catalase Homo sapiens 39-47 12596168-0 2003 Improved methanol-to-olefin catalyst with nanocages functionalized through ship-in-a-bottle synthesis from PH3. Alkenes 21-27 inositol polyphosphate-5-phosphatase D Homo sapiens 75-79 12603147-4 2003 These studies show that the chiral Mo catalyst exists exclusively as the syn isomer and that it offers unique reactivity and selectivity profiles in asymmetric olefin metathesis. Alkenes 160-166 synemin Homo sapiens 73-76 12405805-2 2002 The mechanism of reaction involves formation of an imido-osmium complex which adds intramolecularly to alkenes with complete control of both regio- and stereoselectivity: the formation of syn-aminodiol motifs is now straightforward using this chemistry. Alkenes 103-110 synemin Homo sapiens 188-191 12517165-12 2003 A mechanism with olefin binding to an open site created by CO loss and formation of an Fe-(CH2CHDR) intermediate is indicated. Alkenes 17-23 aldo-keto reductase family 1 member C4 Homo sapiens 94-98 12444634-9 2002 Our theoretical data correctly reproduce the experimental facial syn selectivity of norbornene and norbornadiene epoxidations and compare well with the experimental activation free energies of the peroxy acid epoxidation of all the olefins reported here. Alkenes 232-239 synemin Homo sapiens 65-68 12433171-6 2002 Ozone generated by the ESP corona was the primary cause of alkene reactions in the gas phase. Alkenes 59-65 protein tyrosine phosphatase receptor type V, pseudogene Homo sapiens 23-26 12230409-1 2002 The major insecticide imidacloprid (IMI) is known to be metabolized by human cytochrome P450 3A4 with NADPH by imidazolidine hydroxylation and dehydrogenation to give 5-hydroxy-imidacloprid and the olefin, respectively, and by nitroimine reduction and cleavage to yield the nitrosoimine, guanidine, and urea derivatives. Alkenes 198-204 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 77-96 12227801-5 2002 The syn-beta-silyl alkoxide eliminated stereospecifically at -78 degrees C to give an E olefin, whereas the anti-beta-silyl alkoxide was unreactive. Alkenes 88-94 synemin Homo sapiens 4-7 12298022-0 2002 Chromium-salen-mediated alkene epoxidation: a theoretical and experimental study indicates the importance of spin-surface crossing and the presence of a discrete intermediate. Alkenes 24-30 spindlin 1 Homo sapiens 109-113 12298022-5 2002 The low-spin addition of metal oxo species to an alkene leads to an intermediate which forms epoxide either with a barrier on the low-spin surface or without a barrier after spin inversion. Alkenes 49-55 spindlin 1 Homo sapiens 8-12 12298022-5 2002 The low-spin addition of metal oxo species to an alkene leads to an intermediate which forms epoxide either with a barrier on the low-spin surface or without a barrier after spin inversion. Alkenes 49-55 spindlin 1 Homo sapiens 134-138 12298022-5 2002 The low-spin addition of metal oxo species to an alkene leads to an intermediate which forms epoxide either with a barrier on the low-spin surface or without a barrier after spin inversion. Alkenes 49-55 spindlin 1 Homo sapiens 134-138 12375998-2 2002 The reaction of N-pyridylindolines with CO and ethylene in the presence of Ru3(CO)12 results in direct carbonylation at a C-H bond delta to the pyridine sp2 nitrogen, which represents a new type of C-H/CO/olefin coupling. Alkenes 205-211 Sp2 transcription factor Homo sapiens 153-156 12182661-7 2002 It was hypothesized that incorporation of a quaternary center at C-6 (THP numbering) would restore the facial selectivity with more reactive radical traps by restricting the orientations available to the incoming alkene. Alkenes 213-219 complement C6 Homo sapiens 65-68 12137528-4 2002 An eta2 intermediate was ruled out using low-temperature 13C NMR with the complex in the presence of olefin. Alkenes 101-107 DNA polymerase iota Homo sapiens 3-7 12084621-2 2002 This study with individual recombinant cytochrome P450 (CYP450) isozymes from human liver shows that the principal organoextractable NADPH-dependent metabolites are the 5-hydroxy (major) and olefin (minor) derivatives from hydroxylation and desaturation of the imidazolidine moiety and the nitrosoimine (major), guanidine (minor) and urea (trace) derivatives from reduction and cleavage of the nitroimine substituent. Alkenes 191-197 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 39-54 12123353-2 2002 The key steps include lithium ion-activated SN2-type alkynylation of the tricyclic N,O-acetal leading to exclusive formation of the (6S)-ethynylpiperidine and ring-closing olefin metathesis of the (2R,6S)-cis-2,6-dialkenylpiperidine for constructing the bridged azabicyclononane. Alkenes 172-178 solute carrier family 38 member 5 Homo sapiens 44-47 12095332-1 2002 The class of compounds (RCp)2MX2, where M is a group IV metal, Cp is cyclopentadienyl, R is an alkyl, and X is a halide, has been of continuing interest as precursors for olefin coordination polymerization catalysts. Alkenes 171-177 CGRP receptor component Homo sapiens 24-27 12095351-4 2002 The nature of the bonding between copper and each of the two olefin moieties has been assessed by topological analysis of the BP86/AE1 total electron density. Alkenes 61-67 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 131-134 12084621-2 2002 This study with individual recombinant cytochrome P450 (CYP450) isozymes from human liver shows that the principal organoextractable NADPH-dependent metabolites are the 5-hydroxy (major) and olefin (minor) derivatives from hydroxylation and desaturation of the imidazolidine moiety and the nitrosoimine (major), guanidine (minor) and urea (trace) derivatives from reduction and cleavage of the nitroimine substituent. Alkenes 191-197 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 56-62 11982343-2 2002 Upon addition of IMes to Ru(PPh3)3(CO)H2 at room temperature in the presence of an alkene, C-H bond activation is observed instead. Alkenes 83-89 protein phosphatase 4 catalytic subunit Homo sapiens 28-32 11966428-5 2002 The matrix of 18 resin-supported Pt complexes was then assessed for catalytic activity in the room temperature, solvent-less, hydrosilylation of oct-l-ene using methyldichlorosilane such that alkene: silane: Pt ratio was fixed at 2:1:1x10(-3). Alkenes 192-198 plexin A2 Homo sapiens 145-148 11844699-1 2002 A series of CCR5 antagonists containing bicyclic isoxazolidines was generated through a nitrone mediated cycloaddition with olefins bearing the preferred pharmacophores previously described. Alkenes 124-131 C-C motif chemokine receptor 5 Homo sapiens 12-16 11890791-0 2002 Spin surface crossing in chromium-mediated olefin epoxidation with O(2). Alkenes 43-49 spindlin 1 Homo sapiens 0-4 12120565-1 2002 The ruthenium bis(bipyridine) sulfoxide complexes Ru-1 and Ru-2 exhibit high catalytic activity for epoxidation of unfunctionalized olefins in the presence of [bis(acetoxy)iodo]benzene; with the chiral catalyst, Ru-2, asymmetric induction up to 94% was observed for beta-methylstyrene. Alkenes 132-139 Scm like with four mbt domains 1 Homo sapiens 50-54 12120565-1 2002 The ruthenium bis(bipyridine) sulfoxide complexes Ru-1 and Ru-2 exhibit high catalytic activity for epoxidation of unfunctionalized olefins in the presence of [bis(acetoxy)iodo]benzene; with the chiral catalyst, Ru-2, asymmetric induction up to 94% was observed for beta-methylstyrene. Alkenes 132-139 doublecortin domain containing 2 Homo sapiens 59-63 12120565-1 2002 The ruthenium bis(bipyridine) sulfoxide complexes Ru-1 and Ru-2 exhibit high catalytic activity for epoxidation of unfunctionalized olefins in the presence of [bis(acetoxy)iodo]benzene; with the chiral catalyst, Ru-2, asymmetric induction up to 94% was observed for beta-methylstyrene. Alkenes 132-139 doublecortin domain containing 2 Homo sapiens 212-216 11849090-5 2002 A reanalysis of much earlier work has been done, and all the results are discussed in terms of the effect of substituents on the olefin on the beta(1) values. Alkenes 129-135 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 143-150 12120334-1 2002 Chiral ruthenium(II)-salen complexes [RuII(salen)(PPh3)2] catalyse asymmetric aziridination of alkenes with up to 83% ees, asymmetric amidation of silyl enol ethers with up to 97% ees, and allylic amidation of cholesteryl acetates with good regioselectivity. Alkenes 95-102 caveolin 1 Homo sapiens 50-54 11856046-0 2002 Catalytic radical addition of carbonyl compounds to alkenes by Mn(II)/Co(II)/O(2) system. Alkenes 52-59 mitochondrially encoded cytochrome c oxidase II Homo sapiens 70-76 11856046-1 2002 The radical addition of enolizable carbonyl compounds such as malonates and malononitrile to alkenes was successfully achieved through a catalytic process using the Mn(II)/Co(II)/O(2) system to afford the corresponding adducts in fair to good yields. Alkenes 93-100 mitochondrially encoded cytochrome c oxidase II Homo sapiens 172-178 11757654-3 2001 Chloride as the anionic ligand X, a small chelating angle (n = 1), and reduced steric demand of the substituents R (Cy versus tBu) lead to the most reactive complex in acyclic olefin metathesis, whereas variation of the carbene moiety CHR" has only a modest influence. Alkenes 176-182 chromate resistance; sulfate transport Homo sapiens 235-239 11841938-1 2002 We used olefin metathesis to synthesize C40 derivatives of FK506 and measured their ability, when complexed to FKBP12, to inhibit calcineurin"s phosphatase activity. Alkenes 8-14 FKBP prolyl isomerase 1A pseudogene 4 Homo sapiens 111-117 11717179-5 2001 When deuterium was incorporated into the benzylic position ([d(1)]ezlopitant and [d(7)]ezlopitant), low isotope effects on the formation of both the benzyl alcohol and alkene were observed (1.25-1.55 for CYP3A4 and 1.48-2.61 for CYP2D6), suggesting that abstraction of the benzylic hydrogen is obligatory in the formation of both metabolites. Alkenes 168-174 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 204-216 11717179-5 2001 When deuterium was incorporated into the benzylic position ([d(1)]ezlopitant and [d(7)]ezlopitant), low isotope effects on the formation of both the benzyl alcohol and alkene were observed (1.25-1.55 for CYP3A4 and 1.48-2.61 for CYP2D6), suggesting that abstraction of the benzylic hydrogen is obligatory in the formation of both metabolites. Alkenes 168-174 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 229-235 29711971-1 2001 A variety of terminal alkenes are produced in excellent yields by the rhodium(I)-catalyzed methylenation of aldehydes using TMSCHN2 and PPh3 [Eq. (1)]. Alkenes 22-29 caveolin 1 Homo sapiens 136-140 12240279-1 2001 Ion-exchange of [Ti,Al]-beta with quaternary ammonium acetates greatly enhances the epoxide selectivity in the oxidation of alkenes with hydrogen peroxide; this is due to the selective poisoning of the acid sites without suppressing the oxidation activity of Ti sites. Alkenes 124-131 albumin Homo sapiens 20-28 29711977-2 2001 The suicidal complex 4 2, which inactivates cytochrome P450 during olefin epoxidation, was shown by density functional calculations to be formed from the same high-spin intermediate (4 1-III) that leads to stereochemical scrambling. Alkenes 67-73 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 44-59 11408374-0 2001 Cytochrome P450-catalyzed metabolism of ezlopitant alkene (CJ-12,458), a pharmacologically active metabolite of ezlopitant: enzyme kinetics and mechanism of an alkene hydration reaction. Alkenes 51-57 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 11486961-2 2001 With R" = CF3, C2F5 or CCl3 these complexes are active catalysts for metathesis of acyclic alkenes, including unsaturated fatty acid esters, as well as for ring closing metathesis. Alkenes 91-98 C-C motif chemokine ligand 3 Homo sapiens 23-27 11408374-0 2001 Cytochrome P450-catalyzed metabolism of ezlopitant alkene (CJ-12,458), a pharmacologically active metabolite of ezlopitant: enzyme kinetics and mechanism of an alkene hydration reaction. Alkenes 160-166 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 11091386-0 2000 Ruthenium-Based Four-Coordinate Olefin Metathesis Catalysts The authors thank the NSF for generous support of this research. Alkenes 32-38 N-ethylmaleimide sensitive factor, vesicle fusing ATPase Homo sapiens 82-85 11397413-0 2001 Application of process chemistry and SAR modelling to the evaluation of health findings of lower olefins. Alkenes 97-104 sarcosinemia autosomal recessive Mus musculus 37-40 11405669-0 2001 Olefin metathesis in the design and synthesis of a globally constrained Grb2 SH2 domain inhibitor. Alkenes 0-6 growth factor receptor bound protein 2 Homo sapiens 72-76 11300861-4 2001 The reactions of 7 with silyl enolates, Danishefsky"s diene, and alkenes also proceeded smoothly in the presence of Sc(OTf)3 (20 mol %) to give the corresponding alpha-amino acid, pyridone, and tetrahydroquinoline derivatives, respectively, in good yields. Alkenes 65-72 POU class 5 homeobox 1 Homo sapiens 116-124 11101387-4 2000 The linker is formed by olefin metathesis of an olefinic side chain at the C-11 position introduced by stereoselective cuprate addition. Alkenes 24-30 aldo-keto reductase family 1 member C4 Homo sapiens 75-79 11389637-4 2001 Ab initio computations (B3LYP/6-31+g) for the ene reaction of the ArNO with 2-methyl-2-butene reveal that the steric effects between the aryl group of the enophile and the substituents of the olefin dictate the skew trajectory. Alkenes 192-198 protein tyrosine phosphatase non-receptor type 22 Homo sapiens 26-29 11389637-4 2001 Ab initio computations (B3LYP/6-31+g) for the ene reaction of the ArNO with 2-methyl-2-butene reveal that the steric effects between the aryl group of the enophile and the substituents of the olefin dictate the skew trajectory. Alkenes 192-198 cytohesin 2 Homo sapiens 66-70 29712223-1 2001 Proposed as intermediates in the catalytic oxidation of olefins to ketones, 3-rhoda-1,2-dioxolanes (kappa2 C1 ,O2 -2-peroxyethyl rhodium complexes) have now been prepared by oxygenation of solid [(N4 -ligand)RhI (ethene)]PF6 with air. Alkenes 56-63 sperm associated antigen 17 Homo sapiens 221-224 11405481-8 2001 Four alkenes of the type (Z)-RCH=C(NHCOCH3)CO2R" are treated with H2 (1 atm) and (R)-6+ PF6- or (S)-12+ PF6- (0.5 mol%) in THF at room temperature. Alkenes 5-12 sperm associated antigen 17 Homo sapiens 88-91 11405481-8 2001 Four alkenes of the type (Z)-RCH=C(NHCOCH3)CO2R" are treated with H2 (1 atm) and (R)-6+ PF6- or (S)-12+ PF6- (0.5 mol%) in THF at room temperature. Alkenes 5-12 sperm associated antigen 17 Homo sapiens 104-107 11058062-0 2000 A multinuclear NMR study of [Pt0(PPh3)2(alkene)] compounds containing asymmetric olefins. Alkenes 81-88 protein phosphatase 4 catalytic subunit Homo sapiens 33-37 11058062-5 2000 The chemical shifts of alkene C(1) and C(2) indicate notable polarisation of the olefin after complexation, while the 1J(Pt, C(1)) and 1J(Pt, C(2)) values are in agreement with a stronger interaction of Pt with C(1) than with C(2). Alkenes 23-29 heterogeneous nuclear ribonucleoprotein C Homo sapiens 30-34 11058062-5 2000 The chemical shifts of alkene C(1) and C(2) indicate notable polarisation of the olefin after complexation, while the 1J(Pt, C(1)) and 1J(Pt, C(2)) values are in agreement with a stronger interaction of Pt with C(1) than with C(2). Alkenes 81-87 heterogeneous nuclear ribonucleoprotein C Homo sapiens 30-34 11058062-5 2000 The chemical shifts of alkene C(1) and C(2) indicate notable polarisation of the olefin after complexation, while the 1J(Pt, C(1)) and 1J(Pt, C(2)) values are in agreement with a stronger interaction of Pt with C(1) than with C(2). Alkenes 81-87 complement C2 Homo sapiens 39-43 11058062-5 2000 The chemical shifts of alkene C(1) and C(2) indicate notable polarisation of the olefin after complexation, while the 1J(Pt, C(1)) and 1J(Pt, C(2)) values are in agreement with a stronger interaction of Pt with C(1) than with C(2). Alkenes 81-87 complement C2 Homo sapiens 142-146 11058062-5 2000 The chemical shifts of alkene C(1) and C(2) indicate notable polarisation of the olefin after complexation, while the 1J(Pt, C(1)) and 1J(Pt, C(2)) values are in agreement with a stronger interaction of Pt with C(1) than with C(2). Alkenes 81-87 complement C2 Homo sapiens 142-146 10959849-1 2000 A catalytic enantioselective inverse-electron demand hetero-Diels-Alder reaction of alpha,beta-unsaturated carbonyl compounds with electron-rich alkenes catalyzed by chiral bisoxazolines in combination with Cu(OTf)2 as the Lewis acid is presented. Alkenes 145-152 POU class 2 homeobox 2 Homo sapiens 210-215 10993266-0 2000 Cationic and neutral diphenyldiazomethanerhodium(I) complexes as catalytically active species in the C-C coupling reaction of olefins and diphenyldiazomethane Cationic rhodium(I) complexes cis-[Rh(acetone)2(L)(L")]+ (2: L = L"=C8H14; 3: L=C8H14; L"=PiPr3; 4: L=L"=PiPr3), prepared from [RhCl(C8H14)2]2] and isolated as PF6 salts, catalyze the C-C coupling reaction of diphenyldiazomethane with ethene, propene, and styrene. Alkenes 126-133 sperm associated antigen 17 Homo sapiens 319-322 11931100-1 2000 The combination of two old concepts (the "sigma-donor" capability of M-H bonds and the propensity of unsaturated complexes for addition reactions) has led to the first example of addition oligomerization of an organometallic analogue of olefins: chains containing cis-[Re(CO)4] units joined by Re-H-Re interactions have been obtained through the oligomerization of the unsaturated complex [Re2(micro-H)2(CO)8] promoted by anionic "initiators". Alkenes 237-244 carboxylesterase 1 Homo sapiens 294-298 10926211-0 2000 On the trail of CrO2Cl2 in its reactions with organic compounds The simple metal oxo compound chromyl chloride, CrO2Cl2, displays a very complex reactivity with respect to alkanes, olefins, alcohols, and epoxides. Alkenes 181-188 TNF superfamily member 10 Homo sapiens 7-12 10864762-1 2000 In this process the active catalyst for the reaction, "Cp(TMS)(2)YH", undergoes initial olefin insertion at the vinyl group. Alkenes 88-94 PYD and CARD domain containing Homo sapiens 58-61 10813972-0 2000 Exceptionally pyramidalized olefins: A theoretical study of the cyclopropenyl fused tricycles Tricyclo RHF, MP2, and TCSCF ab initio theory and B3LYP, B3PW91, and SVWN density functional theory were used to study the series of cyclopropenyl-fused tricycles 9-12. Alkenes 28-35 tryptase pseudogene 1 Homo sapiens 108-111 12526399-4 2000 With respect to the palladium-catalyzed [3 + 2] cycloaddition reaction of methylenecyclopropane with alkenes, the path via palladacyclobutanes has been demonstrated to be more favorable than the path via an eta 2 complex. Alkenes 101-108 DNA polymerase iota Homo sapiens 207-212 11006584-8 2000 The major components observed in the pyrolysis-gas chromatography/mass spectrometry of the two heavy fractions were alkanes and alkenes, ranging between C10-C25. Alkenes 128-135 homeobox C10 Homo sapiens 153-156 10823205-2 1999 [reaction: see text] The N-chloramine salt of tert-butylsulfonamide has been shown to be an efficient nitrogen source and the terminal oxidant for catalytic aminohydroxylation and aziridination of olefins, resembling closely Chloramine-T by its behavior in these catalytic reactions. Alkenes 197-204 telomerase reverse transcriptase Homo sapiens 46-50 10606550-2 1999 Because of the large number of high molecular weight products detected and their probable chemical structures, a co-oxidation mechanism is proposed that involves random attack along the alkene chain of the carotenoid by a LOX-generated linoleoylperoxyl radical. Alkenes 186-192 linoleate 9S-lipoxygenase-4 Glycine max 222-225 10639283-0 1999 Synthesis, characterization, and structure-activity relationships of amidine-substituted (bis)benzylidene-cycloketone olefin isomers as potent and selective factor Xa inhibitors. Alkenes 118-124 coagulation factor X Homo sapiens 157-166 10639283-4 1999 In most cases the order of potency of the olefin isomers was (Z,Z) > (E,Z) > (E,E) with the cycloheptanone analogue (1c) showing the most potent factor Xa inhibitory activity. Alkenes 42-48 coagulation factor X Homo sapiens 151-160 10510423-0 1999 Analysis of alkenes by copper ion chemical ionization gas chromatography/mass spectrometry and gas chromatography/tandem mass spectrometry A novel chemical ionization/fast atom bombardment (CI/FAB) source was used to analyse alkenes by chemical ionization mass spectrometry (CI-MS) using copper ions as the ionizing agent. Alkenes 12-19 FA complementation group B Homo sapiens 193-196 29710915-0 1998 Ansa Macrolides as Molecular Workbenches: Stereocontrolled syn Additions to E olefins. Alkenes 78-85 synemin Homo sapiens 59-62 11674258-0 1999 Preparation of C-1 Glycals via Olefin Metathesis. Alkenes 31-37 heterogeneous nuclear ribonucleoprotein C Homo sapiens 15-18 9990451-0 1999 New minimal substrate structural requirements in the enzymatic peroxidation of alkenes with soybean lipoxygenase. Alkenes 79-86 linoleate 9S-lipoxygenase-4 Glycine max 100-112 11672325-1 1998 Reactivity in the hydrosilylation of alkenes and alkynes catalyzed by the organoyttrium catalysts Cp(2)YMe.THF and [Cp(TMS)(2)YMe](2) is generally determined by the steric environment of the substrate. Alkenes 37-44 PYD and CARD domain containing Homo sapiens 119-122 10051944-1 1998 PURPOSE: In the presence of carbon dioxide absorbents, sevoflurane is degraded to CF2 = C(CF3)OCH2F, an olefin compound A. Alkenes 104-110 ATPase H+ transporting accessory protein 1 Homo sapiens 82-85 11672263-3 1998 The alkenes 7 and 10 are prepared from Bu(3)SnCH(2)CH=CH(2) and IR(f8) (hnu, CH(2)Cl(2), 81%) or ICH(2)R(f8) (VAZO, refluxing CF(3)C(6)H(5), 56%). Alkenes 4-11 interferon regulatory factor 8 Homo sapiens 64-69 9871592-1 1998 An alkylation method of docetaxel at the C-10 position has been established by a radical coupling reaction using a 10-xanthate derivative of 7-O-TES-10-deacetylbaccatin III and appropriate alkenes. Alkenes 189-196 homeobox C10 Homo sapiens 41-45 8735469-13 1996 The data indicate that (1) several CYP families (CYP2A, CYP2B, CYP2D and CYP3A) could be responsible for the hepatic metabolism of 2-EHA, (2) the same metabolites were formed in rats and man and (3) an unsaturated terminal olefin, 2-ethyl-5-hexenoic acid is formed in the liver. Alkenes 223-229 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 35-38 9313865-7 1997 These results are in sharp contrast with the corresponding olefins, N omega-allyl-L-arginine and N omega-allyl-N omega-hydroxy-L-arginine recently reported to be potent time-dependent, irreversible inhibitors of nNOS (Zhang, H. Q.; Dixon, R. P.; Marletta, M. A.; Silverman, R. B., J. Alkenes 59-66 nitric oxide synthase 1 Homo sapiens 212-216 11666793-0 1996 Synthesis, Structure, and Characterization of a Novel Manganese(IV) Monomer, [Mn(IV)(Me(3)TACN)(OMe)(3)](PF(6)) (Me(3)TACN = N,N",N"-Trimethyl-1,4,7-triazacyclononane), and Its Activity toward Olefin Oxidation with Hydrogen Peroxide. Alkenes 193-199 sperm associated antigen 17 Homo sapiens 105-110 11667565-0 1996 Olefin Inversion: Stereospecific Olefin Synthesis from Vicinal Alkoxyiodoalkanes with Butyllithium by an E2 Syn Mechanism. Alkenes 0-6 synemin Homo sapiens 40-43 11667565-0 1996 Olefin Inversion: Stereospecific Olefin Synthesis from Vicinal Alkoxyiodoalkanes with Butyllithium by an E2 Syn Mechanism. Alkenes 33-39 synemin Homo sapiens 40-43 11667407-2 1996 The olefin undergoes two types of palladium-catalyzed reactions: (a) arylation to provide C-3 arylated derivatives and (b) competing double bond isomerization. Alkenes 4-10 complement C3 Homo sapiens 90-93 8735469-0 1996 CYP enzymes catalyze the formation of a terminal olefin from 2-ethylhexanoic acid in rat and human liver. Alkenes 49-55 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 0-3 10099493-1 1998 Equimolar amounts of each component, an aldehyde, an amine, and a silyl enol ether or an alkene, react smoothly in the presence of Ln(OTf)3, and the work-up and purification processes are performed by simply passing through a short column. Alkenes 90-96 POU class 5 homeobox 1 Homo sapiens 135-140 11671497-3 1997 Formation of trans epoxides by syn epoxidation is a consequence of the conformational flexibility of the nine-membered ring, which places the alcohol at C-5 close to the alpha-face of the endo-alkene in 4 and close to the beta-face in 3 and 5. Alkenes 193-199 synemin Homo sapiens 31-34 9084912-11 1997 However, it appears that the end product of this sequence, namely, DASO2, undergoes further CYP2E1-mediated activation of the olefinic pi-bond, a reaction which transforms many terminal olefins to potent mechanism-based P450 inhibitors. Alkenes 186-193 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 92-98 11666793-8 1996 [Mn(IV)(Me(3)TACN)(OMe)(3)](PF(6)) was found to catalyze the oxidation of water-soluble olefins using hydrogen peroxide as the oxidant in an aqueous medium. Alkenes 88-95 sperm associated antigen 17 Homo sapiens 28-33 11667282-6 1996 Thermolysis or photolysis of 8e or9b led via electrocyclic ring opening to a vinyl ketene which was trapped by MeOH, alkenes, dienes, or oxygen to produce polyfunctional unsaturated esters 29 and 30 or 8-membered ring lactone 31, fused cyclobutanones 33 and 34, pyranone 38, or gamma-lactone 39, respectively. Alkenes 117-124 olfactory receptor family 1 subfamily B member 1 Homo sapiens 32-36 11667214-3 1996 Reaction of 2-methyl-endo-tricyclo[3.2.1.0(2,4)]oct-6-ene (2) with bromine in CCl(4) and methanol gave products of reaction at the alkene site. Alkenes 131-137 POU class 3 homeobox 1 Homo sapiens 48-53 8735469-13 1996 The data indicate that (1) several CYP families (CYP2A, CYP2B, CYP2D and CYP3A) could be responsible for the hepatic metabolism of 2-EHA, (2) the same metabolites were formed in rats and man and (3) an unsaturated terminal olefin, 2-ethyl-5-hexenoic acid is formed in the liver. Alkenes 223-229 cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus 73-78 7887959-1 1995 Squalene epoxidase is the only known flavoprotein that catalyzes the epoxidation of an olefin. Alkenes 87-93 squalene epoxidase Homo sapiens 0-18 7574697-7 1995 Purified recombinant Cyp 2C8 and 2C10 were reconstituted in the presence of NADPH and NADPH-cytochrome P450 reductase and shown to metabolize arachidonic via olefin epoxidation with both proteins generating, almost exclusively, epoxygenase-derived products (94 and 90% of total products, respectively). Alkenes 158-164 cytochrome P450 family 2 subfamily C member 8 Homo sapiens 21-37 8638935-1 1996 Cytochrome P450 enzymes oxidize aldehydes either to the corresponding acid or, via a decarboxylation mechanism, to an olefin one carbon shorter than the parent substrate. Alkenes 118-124 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 7681661-1 1993 Cytochrome c (cyt.c) was shown to catalyze cytochrome P450 (P450)-like oxidative reactions, such as N-, and O-demethylation, S-oxidation, and epoxidation of olefins. Alkenes 157-164 cytochrome c, somatic Homo sapiens 0-12 7883047-1 1995 Kidney cysteine conjugate beta-lyase (glutamine transaminase K, kyneurenine aminotransferase, EC 2.6.1.64) metabolises the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites which can produce nephrotoxicity and neurotoxicity in experimental animals and man. Alkenes 166-173 kynurenine aminotransferase 1 Homo sapiens 38-92 7696528-0 1994 The oxidation of tetrasubstituted alkenes by cytochrome P450. Alkenes 34-41 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 56-60 7696528-1 1994 Hexamethyl(Dewar benzene) (HMDB) was selected to probe the intermediacy of an alkene radical cation during cytochrome P450 (P450) catalyzed epoxidation. Alkenes 78-84 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 118-122 7696528-1 1994 Hexamethyl(Dewar benzene) (HMDB) was selected to probe the intermediacy of an alkene radical cation during cytochrome P450 (P450) catalyzed epoxidation. Alkenes 78-84 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 124-128 7696528-5 1994 The rates of alkene epoxidation by model systems tend to increase with increasing alkene substitution, but it is apparent that P450 has additional mechanistic options or constraints that depress the rate of epoxidation with increasing alkene substitution. Alkenes 13-19 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 127-131 7696528-5 1994 The rates of alkene epoxidation by model systems tend to increase with increasing alkene substitution, but it is apparent that P450 has additional mechanistic options or constraints that depress the rate of epoxidation with increasing alkene substitution. Alkenes 82-88 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 127-131 7696528-5 1994 The rates of alkene epoxidation by model systems tend to increase with increasing alkene substitution, but it is apparent that P450 has additional mechanistic options or constraints that depress the rate of epoxidation with increasing alkene substitution. Alkenes 82-88 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 127-131 7696528-6 1994 The failure of P450 to epoxidize tetrasubstituted alkenes illustrates a failure of P450 model systems to truly mimic the chemistry of the P450 iron-oxo species. Alkenes 50-57 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 15-19 8257963-5 1993 The method uses [C-11]CH3I and combines a Wittig reaction and a stereoselective OsO4 catalyzed alkene hydroxylation. Alkenes 95-101 aldo-keto reductase family 1 member C4 Homo sapiens 17-21 8257963-6 1993 The OsO4 hydroxylation of the [C-11]-labeled alkene (9) is accomplished in less than 10 min with high stereoselectivity (94:6) in favor of the 6-[C-11]-D-gluco-isomer. Alkenes 45-51 aldo-keto reductase family 1 member C4 Homo sapiens 31-35 8257963-6 1993 The OsO4 hydroxylation of the [C-11]-labeled alkene (9) is accomplished in less than 10 min with high stereoselectivity (94:6) in favor of the 6-[C-11]-D-gluco-isomer. Alkenes 45-51 aldo-keto reductase family 1 member C4 Homo sapiens 146-150 8108434-2 1994 Human glutathione transferases (GSTs; RX:glutathione R-transferase, EC 2.5.1.18) of classes Alpha, Mu, and Pi were shown to promote the conjugation of glutathione with base propenals and related alkenes. Alkenes 195-202 glutathione S-transferase alpha 1 Homo sapiens 32-36 7681661-1 1993 Cytochrome c (cyt.c) was shown to catalyze cytochrome P450 (P450)-like oxidative reactions, such as N-, and O-demethylation, S-oxidation, and epoxidation of olefins. Alkenes 157-164 cytochrome c, somatic Homo sapiens 14-19 1566044-4 1992 Alkenes from microalgae, such as n-C21:6, n-C17:1 and unusual C25 and C30 isoprenoid alkenes, are often the most abundant single components in sedimentary hydrocarbon distributions. Alkenes 0-7 TBL1X/Y related 1 Homo sapiens 35-38 1566044-4 1992 Alkenes from microalgae, such as n-C21:6, n-C17:1 and unusual C25 and C30 isoprenoid alkenes, are often the most abundant single components in sedimentary hydrocarbon distributions. Alkenes 0-7 cytokine like 1 Homo sapiens 44-47 1924356-0 1991 Catalysis by cytochrome P-450 of an oxidative reaction in xenobiotic aldehyde metabolism: deformylation with olefin formation. Alkenes 109-115 cytochrome P-450 Oryctolagus cuniculus 13-29 24257918-4 1991 In addition, the 11 corresponding epoxides were prepared to aid in identification of the metabolites of each modified alkene. Alkenes 118-124 activation induced cytidine deaminase Homo sapiens 60-63 2085421-3 1990 The bridgehead atom of the alkene group, C7, has one short [C7--C6 1.485 (6) A] and one long [C7--C11, 1.541 (6) A] Csp2--Csp3 bond. Alkenes 27-33 RNA polymerase III subunit K Homo sapiens 98-101 24242350-7 1991 Use of CS 2 (+ ) to generate the alkene molecular ion by charge exchange yields the same information without the need to carry out a mass-selection step for the ionized alkene. Alkenes 33-39 chorionic somatomammotropin hormone 2 Homo sapiens 7-11 24242350-7 1991 Use of CS 2 (+ ) to generate the alkene molecular ion by charge exchange yields the same information without the need to carry out a mass-selection step for the ionized alkene. Alkenes 169-175 chorionic somatomammotropin hormone 2 Homo sapiens 7-11 33872504-2 2021 Our convergent synthesis features a [3+2] dipolar cycloaddition of an olefin-bearing 1,3-syn diol unit and an oxime segment containing 1,2-syn diol functionality as the key step. Alkenes 70-76 synemin Homo sapiens 15-18 33872504-2 2021 Our convergent synthesis features a [3+2] dipolar cycloaddition of an olefin-bearing 1,3-syn diol unit and an oxime segment containing 1,2-syn diol functionality as the key step. Alkenes 70-76 synemin Homo sapiens 89-92 34914394-6 2021 This synthetic strategy is also amenable to functionalization of feedstock gaseous alkenes at 1 atm. Alkenes 83-90 ATM serine/threonine kinase Homo sapiens 96-99 32796938-6 2020 We further show that the NAC catalyst is versatile for dehydrogenation of ethylbenzene and tetrahydroquinoline as well as for hydrogenation of common unsaturated functionalities, including ketone, alkene, alkyne, and nitro groups. Alkenes 197-203 synuclein alpha Homo sapiens 25-28 34914168-3 2022 Our synthesis of this target, a doubly B-doped hexabenzopentacene ( B 2 -HBP ), employs six net C-H borylations of an alkene, comprising consecutive hydroboration/electrophilic borylation/dehydrogenation and BBr 3 /AlCl 3 /2,6-dichloropyridine-mediated C-H borylation steps. Alkenes 118-124 heme binding protein 1 Homo sapiens 73-76 34879201-3 2021 The eta2 coordination complexes bind side-on, akin to olefins, via a borataalkene unit, although with the carbon atom much more proximal to the metal center than boron. Alkenes 54-61 DNA polymerase iota Homo sapiens 4-8 34523761-5 2021 In order to explain the uncommon regioselectivity of the Paterno-Buchi reaction with these alkenes, electrostatic-potential derived charges (ESP) have been determined. Alkenes 91-98 protein tyrosine phosphatase receptor type V, pseudogene Homo sapiens 141-144 34874373-7 2021 The results demonstrate that the B12-catalyzed reductive dechlorination of olefins in microbes should proceed through an inner-sphere ET pathway. Alkenes 75-82 major facilitator superfamily domain containing 11 Homo sapiens 134-136 34775756-2 2021 Because the redox potentials of alkenes are higher than those of most high-valent metal-oxo species, the electron transfer (ET) from the alkene to the high-valent metal-oxo species in the epoxidation reaction is endergonic and must be coupled with another exergonic process. Alkenes 32-39 major facilitator superfamily domain containing 11 Homo sapiens 124-126 34775756-2 2021 Because the redox potentials of alkenes are higher than those of most high-valent metal-oxo species, the electron transfer (ET) from the alkene to the high-valent metal-oxo species in the epoxidation reaction is endergonic and must be coupled with another exergonic process. Alkenes 137-143 major facilitator superfamily domain containing 11 Homo sapiens 124-126 34775756-3 2021 To reveal the mechanism of the ET, we performed a Marcus plot analysis for the epoxidation reaction of the oxoiron(IV) porphyrin pi-cation radical complex (compound I) with alkene. Alkenes 173-179 major facilitator superfamily domain containing 11 Homo sapiens 31-33 34775756-7 2021 As the alkene comes close to the oxo ligand, the energy of the highest occupied molecular orbital (HOMO) of the alkene increases and the energy for the ET becomes small enough to allow the ET. Alkenes 7-13 major facilitator superfamily domain containing 11 Homo sapiens 152-154 34775756-7 2021 As the alkene comes close to the oxo ligand, the energy of the highest occupied molecular orbital (HOMO) of the alkene increases and the energy for the ET becomes small enough to allow the ET. Alkenes 7-13 major facilitator superfamily domain containing 11 Homo sapiens 189-191 34775756-8 2021 Finally, the ET occurs from the HOMO of the alkene to the porphyrin pi-radical orbital. Alkenes 44-50 major facilitator superfamily domain containing 11 Homo sapiens 13-15 34775756-9 2021 The shift of one electron from the HOMO of the alkene by the ET simultaneously results in the O-C half bond formation between the oxo ligand and the alkene. Alkenes 47-53 major facilitator superfamily domain containing 11 Homo sapiens 61-63 34775756-9 2021 The shift of one electron from the HOMO of the alkene by the ET simultaneously results in the O-C half bond formation between the oxo ligand and the alkene. Alkenes 149-155 major facilitator superfamily domain containing 11 Homo sapiens 61-63 34633825-0 2021 Enantioselective Cross-Coupling of Electron-Deficient Alkenes via Ir-Catalyzed Vinylic sp2 C-H Alkylation. Alkenes 54-61 Sp2 transcription factor Homo sapiens 87-90 34633825-2 2021 This is the first example of the enantioselective cross-coupling of two different electron-deficient alkenes via vinylic sp2 C-H activation, and polyfunctionalized chiral compounds were obtained. Alkenes 101-108 Sp2 transcription factor Homo sapiens 121-124 34725344-2 2021 Herein, we report an intermolecular syn-1,2-arylamination of unactivated alkenes with arylboronic acids and O-benzoylhydroxylamine electrophiles with Ni(II) catalyst. Alkenes 73-80 synapsin I Homo sapiens 36-41 34669411-3 2021 Control experiments and density functional theory (DFT) calculations support the idea that the palladium(0) acts as a pi-Lewis base catalyst by chemoselectively forming eta2-complexes with the alkene moiety of 1,3-enynes, thus increasing the nucleophilicity of the alkyne group based on the principle of vinylogy, to attack imines enantioselectively. Alkenes 193-199 DNA polymerase iota Homo sapiens 169-173 34387372-0 2021 Isomerization of Functionalized Olefins Using the Dinuclear Catalyst (PdI(mu-Br)(PtBu3))2: A Mechanistic Study. Alkenes 32-39 peptidyl arginine deiminase 1 Homo sapiens 70-73 34718648-2 2022 Though biological production of alkanes has been reported in various microorganisms, the reports citing photosynthetic cyanobacteria as natural producers have been the most consistent for the long-chain alkanes and alkenes (C15 to C19). Alkenes 215-222 placenta associated 8 Homo sapiens 224-227 34607013-2 2022 At the heart of this metabolic pathway is an enzyme known as retinal pigment epithelium 65 kDa protein (RPE65), which catalyzes an unusual, possibly biochemically unique, reaction consisting of a coupled all-trans-retinyl ester hydrolysis and alkene geometric isomerization to produce 11-cis-retinol. Alkenes 243-249 retinoid isomerohydrolase RPE65 Homo sapiens 104-109 34416071-5 2021 Using Rh2(S-PTAD)4 as catalyst, several diazo compounds were selectively coupled with a thioketone to give one of the four anti -folded overcrowded alkene stereoisomers upon reduction. Alkenes 148-154 Rh associated glycoprotein Homo sapiens 6-9 34346453-2 2021 In this study, we developed a new catalytic system for hydroxycarbonylation of alkenes with HCOOH using a Vaska-type Rh complex with an iodide ligand, RhI(CO)(PPh3)2 (1), as the catalyst, and a quaternary ammonium iodide salt as the promoter for the catalyst. Alkenes 79-86 caveolin 1 Homo sapiens 159-163 34693402-0 2021 Substituent Effects Provide Access to Tetrasubstituted Ring-Opening Olefin Metathesis of Bicyclo(4.2.0)oct-6-enes. Alkenes 68-74 POU class 3 homeobox 1 Homo sapiens 103-108 34424711-0 2021 Potent Inhibition of Nicotinamide N-Methyltransferase by Alkene-Linked Bisubstrate Mimics Bearing Electron Deficient Aromatics. Alkenes 57-63 nicotinamide N-methyltransferase Homo sapiens 21-53 34375090-0 2021 Catalytic, Enantioselective Syn-Oxyamination of Alkenes. Alkenes 48-55 synemin Homo sapiens 28-31 34098255-7 2021 Our results provide new insights into the origin of C17 alkadienes and C17-C20 alkenes in environmental and geological samples, and these alkenes can potentially be applied as lichen biomarkers. Alkenes 79-86 cytokine like 1 Homo sapiens 71-74 34098255-7 2021 Our results provide new insights into the origin of C17 alkadienes and C17-C20 alkenes in environmental and geological samples, and these alkenes can potentially be applied as lichen biomarkers. Alkenes 138-145 cytokine like 1 Homo sapiens 52-55 34098255-7 2021 Our results provide new insights into the origin of C17 alkadienes and C17-C20 alkenes in environmental and geological samples, and these alkenes can potentially be applied as lichen biomarkers. Alkenes 138-145 cytokine like 1 Homo sapiens 71-74 34500654-2 2021 Such tagged NHC ligands represent an attractive starting point for the synthesis of olefin metathesis ruthenium catalysts tagged in non-dissociating ligands. Alkenes 84-90 high mobility group nucleosomal binding domain 4 Homo sapiens 12-15 34075694-10 2021 Electrochemical reductions of an alkene and alkyne were also catalyzed by the B12 complex. Alkenes 33-39 NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens 78-81 34380308-5 2021 Mechanistic studies support the working model involving a thiol-catalyzed radical chain process wherein the atoms from formate are delivered across the alkene substrate via CO2 - as a key reactive intermediate. Alkenes 152-158 complement C2 Homo sapiens 173-176 34286753-1 2021 Studies into the Cp*Rh(iii)-catalysed hydroarylation of alkenes with aryl acyl silanes led to the discovery of a new synthetic strategy to access unique silicon derived indene frameworks. Alkenes 56-63 ceruloplasmin Homo sapiens 17-19 34466792-0 2021 The serendipitous effect of KF in Ritter reaction: Photo-induced amino-alkylation of alkenes. Alkenes 85-92 arylformamidase Homo sapiens 28-30 34286753-2 2021 Rather than protodemetalation of the metal enolate formed following insertion of an alkene into the aryl C-H bond, intramolecular aldol condensation of the acyl silane occurred to generate a series of 2-formyl- and 2-acetyl-3-silyl indenes. Alkenes 84-90 ceruloplasmin Homo sapiens 105-106 34260254-1 2021 Radical alpha-C-H functionalization of alk-5-enyl boronic esters with concomitant functionalization of the alkene moiety is reported. Alkenes 107-113 transforming growth factor beta receptor 1 Homo sapiens 39-44 34153838-8 2021 Among all GCGR ICL3 mutants bearing a strained alkene, the H339SphK/2"-aTCOK mutants provided the best reaction partners for the BODIPY-Tz1/4 reagents in the bioorthogonal labeling reactions. Alkenes 47-53 glucagon receptor Homo sapiens 10-14 34105846-2 2021 The P-Al bond added to ethylene and relatively small terminal alkenes (propylene and hex-1-ene) at room temperature to give the corresponding alkene-adducts. Alkenes 62-69 exonuclease 1 Homo sapiens 85-90 34105846-2 2021 The P-Al bond added to ethylene and relatively small terminal alkenes (propylene and hex-1-ene) at room temperature to give the corresponding alkene-adducts. Alkenes 142-148 exonuclease 1 Homo sapiens 85-90 34745710-0 2021 Rh(III)-Catalyzed Three-Component Syn-Carboamination of Alkenes Using Arylboronic Acids and Dioxazolones. Alkenes 56-63 synemin Homo sapiens 34-37 34264662-6 2021 Density functional theory calculations revealed a mechanism involving PdH formation and migratory insertion into the alkene, followed by C-C bond formation. Alkenes 117-123 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 70-73 34282613-1 2021 A highly efficient catalytic method has been developed for asymmetric radical cyclopropanation of alkenes with in situ-generated alpha-heteroaryldiazomethanes via Co(II)-based metalloradical catalysis (MRC). Alkenes 98-105 mitochondrially encoded cytochrome c oxidase II Homo sapiens 163-169 34282613-2 2021 Through fine-tuning the cavity-like environments of newly-synthesized D2-symmetric chiral amidoporphyrins as the supporting ligand, the optimized Co(II)-based metalloradical system is broadly applicable to alpha-pyridyl and other alpha-heteroaryldiazomethanes for asymmetric cyclopropanation of wide-ranging alkenes, including several types of challenging substrates. Alkenes 308-315 mitochondrially encoded cytochrome c oxidase II Homo sapiens 146-152 34282613-4 2021 Combined computational and experimental studies further support the underlying stepwise radical mechanism of the Co(II)-based olefin cyclopropanation involving alpha- and gamma-metalloalkyl radicals as the key intermediates. Alkenes 126-132 mitochondrially encoded cytochrome c oxidase II Homo sapiens 113-119 34236835-0 2021 Rh(II)-Catalyzed Alkynylcyclopropanation of Alkenes by Decarbenation of Alkynylcycloheptatrienes. Alkenes 44-51 Rh blood group D antigen Homo sapiens 0-6 34272392-3 2021 Here we report a cobalt-catalyzed regioselective difluoroalkylarylation of both activated and unactivated alkenes with solid arylzinc pivalates and difluoroalkyl bromides through a cascade Csp3-Csp3/Csp3-Csp2 bond formation under mild reaction conditions. Alkenes 106-113 regulator of calcineurin 2 Homo sapiens 204-208 34133148-0 2021 Tandem Photocatalysis Protocol for Hydrogen Generation/Olefin Hydrogenation Using Pd-g-C3N4-Imine/TiO2 Nanoparticles. Alkenes 55-61 phosphoglycerate dehydrogenase Homo sapiens 82-86 34176981-2 2021 The key step involves generating the alkene moiety via elimination of a suitable precursor after it has been inserted into a peptide chain. Alkenes 37-43 amyloid beta precursor protein Homo sapiens 70-71 34102836-5 2021 We show that the reactivity of CO2 - with electron-poor olefins results in either single electron reduction or alkene hydrocarboxylation, where substrate reduction potentials can be utilized to predict reaction outcome. Alkenes 56-63 complement C2 Homo sapiens 31-34 34102836-5 2021 We show that the reactivity of CO2 - with electron-poor olefins results in either single electron reduction or alkene hydrocarboxylation, where substrate reduction potentials can be utilized to predict reaction outcome. Alkenes 111-117 complement C2 Homo sapiens 31-34 34176981-2 2021 The key step involves generating the alkene moiety via elimination of a suitable precursor after it has been inserted into a peptide chain. Alkenes 37-43 amyloid beta precursor protein Homo sapiens 123-124 34069753-3 2021 In this study, we investigate i,i + 1 hydrocarbon stapling between cis-4-allyloxy-l-proline and various olefin-tethered amino acids. Alkenes 104-110 suppressor of cytokine signaling 6 Homo sapiens 67-72 35609341-6 2022 The triplet excitons are shown to induce a highly diastereomeric syn-selective 2 + 2 cycloaddition starting from olefins. Alkenes 113-120 synemin Homo sapiens 65-68 34745713-3 2021 Merger of this Cu-catalyzed cross-coupling enables a broad range of nucleophiles (e.g. CN, SCN, N3, vinyl, allyl) to engage in radical amino-functionalizations of olefins. Alkenes 163-170 sorcin Homo sapiens 91-94 34163699-0 2021 Ruthenium-catalyzed formal sp3 C-H activation of allylsilanes/esters with olefins: efficient access to functionalized 1,3-dienes. Alkenes 74-81 Sp3 transcription factor Homo sapiens 27-30 34164088-0 2021 Rh(i)- and Rh(ii)-catalyzed C-H alkylation of benzylamines with alkenes and its application in flow chemistry. Alkenes 64-71 Rh blood group D antigen Homo sapiens 14-16 35437987-0 2022 Reactions of Tri-tert-Butylphosphatetrahedrane as a Spring-Loaded Phosphinidene Synthon Featuring Nickel-Catalyzed Transfer to Unactivated Alkenes. Alkenes 139-146 tRNA-Ile (anticodon AAT) 9-1 Homo sapiens 13-16 35583475-0 2022 Regioselective Synthetic Approach to Higher Alkenes from Lower Alkenes with Sulfoxides in the Fe3+/H2O2 System via Direct Alkylation or Arylation of the Csp2-H Bond on the C C Bond of Alkenes. Alkenes 44-51 regulator of calcineurin 2 Homo sapiens 153-157 35583475-0 2022 Regioselective Synthetic Approach to Higher Alkenes from Lower Alkenes with Sulfoxides in the Fe3+/H2O2 System via Direct Alkylation or Arylation of the Csp2-H Bond on the C C Bond of Alkenes. Alkenes 63-70 regulator of calcineurin 2 Homo sapiens 153-157 35583475-0 2022 Regioselective Synthetic Approach to Higher Alkenes from Lower Alkenes with Sulfoxides in the Fe3+/H2O2 System via Direct Alkylation or Arylation of the Csp2-H Bond on the C C Bond of Alkenes. Alkenes 184-191 regulator of calcineurin 2 Homo sapiens 153-157 35583475-3 2022 In this reaction, sulfoxides afforded one Csp3 or Csp2 atom to the C C bond of alkenes; one new Csp2-Csp3 bond or Csp2-Csp2 bond was formed. Alkenes 79-86 regulator of calcineurin 2 Homo sapiens 50-54 35583475-3 2022 In this reaction, sulfoxides afforded one Csp3 or Csp2 atom to the C C bond of alkenes; one new Csp2-Csp3 bond or Csp2-Csp2 bond was formed. Alkenes 79-86 regulator of calcineurin 2 Homo sapiens 96-100 35583475-3 2022 In this reaction, sulfoxides afforded one Csp3 or Csp2 atom to the C C bond of alkenes; one new Csp2-Csp3 bond or Csp2-Csp2 bond was formed. Alkenes 79-86 regulator of calcineurin 2 Homo sapiens 114-118 35583475-3 2022 In this reaction, sulfoxides afforded one Csp3 or Csp2 atom to the C C bond of alkenes; one new Csp2-Csp3 bond or Csp2-Csp2 bond was formed. Alkenes 79-86 regulator of calcineurin 2 Homo sapiens 119-123 35631907-2 2022 Compared with BN-, NBN- and BNB-doped polycyclic aromatic hydrocarbons, NBN-embedded polymers are poised to expand the diversity and functionality of olefin polymers, but this new class of materials remain underexplored. Alkenes 150-156 nibrin Homo sapiens 72-75 35601311-2 2022 For hydrocarbon cracking, the industrial catalyst is an important parameter in reaction technology to produce valuable compounds, e.g., light olefins (C3-C5) and gasoline from crude oil fractions with high molecular weight (C16+). Alkenes 142-149 ADAM metallopeptidase with thrombospondin type 1 motif 1 Homo sapiens 151-156 35476545-2 2022 The triple catalysis realizes three key elementary steps in a single catalytic cycle: (1) Co(III) hydride generation by photochemical reduction of Co(II) followed by protonation, (2) metal hydride hydrogen atom transfer (MHAT) of alkenes by Co(III) hydride, and (3) oxidation of the alkyl Co(III) complex to alkyl Co(IV). Alkenes 230-237 mitochondrially encoded cytochrome c oxidase II Homo sapiens 147-153 35510306-1 2022 A Ru(bpy) 3 photocatalyst is applied to the rapid trans to cis isomerization of a range of alkene-containing pharmacological agents, including combretastatin (CA-4), a clinical candidate in oncology, and resveratrol derivatives, switching their configuration from inactive substances to potent cytotoxic agents. Alkenes 91-97 carbonic anhydrase 4 Homo sapiens 159-163 35436110-0 2022 Electrophilic Sulfur Reagent Design Enables Directed syn-Carbosulfenylation of Unactivated Alkenes. Alkenes 91-98 synemin Homo sapiens 53-56 35491241-4 2022 Importantly, the olefin-linked conjugated backbone of sp2 -TPE-COF works as a signal amplified transducer for metal ion sensing. Alkenes 17-23 Sp2 transcription factor Homo sapiens 54-57 35435655-17 2022 Alkenes that efficiently capture CF2 attenuate the chain-branching, suppress autoacceleration, and lead to less rapid difluorocyclopropanation. Alkenes 0-7 ATPase H+ transporting accessory protein 1 Homo sapiens 33-36 35139301-4 2022 The soluble dihydride complex ((Me5PACP)2Sr2(mu-H)2)(B(C6H4-4-nBu)4)2 was tested in olefin hydrogenation and hydrosilylation catalysis. Alkenes 84-90 familial progressive hyperpigmentation 1 Homo sapiens 45-51 35137987-3 2022 As organo boron substrates with leaving groups in b-position can undergo stereospecific syn - or anti -elimination, this chemistry harbors great potential for the synthesis of complex olefins. Alkenes 184-191 synemin Homo sapiens 88-91 35088939-2 2022 Despite significant achievements on the preparation of sp 3 1,1,1- and 1,1,2-triorganometallic B,B,B-reagents, catalytic approaches that enable the installation of multiple boryl groups at skipped carbons of unactivated alkenes still remain elusive. Alkenes 220-227 Sp1 transcription factor Homo sapiens 55-72 35253830-7 2022 However, surprisingly, one of our preptin analogues, a nonapeptide stabilised by olefin metathesis between positions 3 and 7 of the amino acid chain, had a similar ability to stimulate calcium ions" release to the full-length human preptin. Alkenes 81-87 insulin like growth factor 2 Homo sapiens 34-41 35438835-0 2022 Synthesis and Characterization of a Selenide Catalyst for the Activation of Alkenes through Se pi Bonding. Alkenes 76-83 squalene epoxidase Homo sapiens 92-94 35438835-4 2022 Significantly, Se pi bonding activation mode can be exploited to achieve intermolecular enyne cyclizations and controlled cross coupling of triple alkenes. Alkenes 149-156 squalene epoxidase Homo sapiens 15-17 35171590-1 2022 The first direct general method for N-Me aziridination of electron-deficient olefins, enones, is described using N-methyl-O-tosylhydroxylamine as the aminating agent in the presence of a Cu(OTf)2 catalyst. Alkenes 77-84 POU class 2 homeobox 2 Homo sapiens 187-195 35494099-1 2022 Diazomalonates have been demonstrated as effective metalloradicophiles for asymmetric radical olefin cyclopropanation via Co(II)-metalloradical catalysis (MRC). Alkenes 94-100 mitochondrially encoded cytochrome c oxidase II Homo sapiens 122-128 35494099-3 2022 The Co(II)-catalyzed asymmetric cyclopropanation, which operates at room temperature without slow addition of the diazo compound, is generally applicable to broad-ranging olefins and tolerates various functionalities, providing a streamlined synthesis of chiral 1,1-cyclopropanediesters in high yields with both high diastereoselectivity and enantioselectivity. Alkenes 171-178 mitochondrially encoded cytochrome c oxidase II Homo sapiens 4-10 35160434-0 2022 Olefin-Metathesis-Derived Norbornene-Ethylene-Vinyl Acetate/Vinyl Alcohol Multiblock Copolymers: Impact of the Copolymer Structure on the Gas Permeation Properties. Alkenes 0-6 gastrin Homo sapiens 138-141 35103474-2 2022 Alkene geometry is selectively transferred to the newly formed carbon-carbon bond, resulting in stereochemical control of C1, C2, and C3 of the resulting 2-alkoxy-3-N-tosyl-4-alkyl-5-hexene products. Alkenes 0-6 heterogeneous nuclear ribonucleoprotein C Homo sapiens 122-136 35099966-1 2022 alpha-Alkynyldiazomethanes, generated in situ from the corresponding sulfonyl hydrazones in the presence of a base, can serve as effective metalloradicophiles in Co(II)-based metalloradical catalysis (MRC) for asymmetric cyclopropanation of alkenes. Alkenes 241-248 mitochondrially encoded cytochrome c oxidase II Homo sapiens 162-168 35099966-2 2022 With D2-symmetric chiral amidoporphyrin 2,6-DiMeO-QingPhyrin as the optimal supporting ligand, the Co(II)-based metalloradical system can efficiently activate different alpha-alkynyldiazomethanes at room temperature for highly asymmetric cyclopropanation of a broad range of alkenes. Alkenes 275-282 mitochondrially encoded cytochrome c oxidase II Homo sapiens 99-105 35099966-4 2022 Combined computational and experimental studies offer several lines of evidence in support of the underlying stepwise radical mechanism for the Co(II)-catalyzed olefin cyclopropanation involving a unique alpha-metalloradical intermediate that is associated with two resonance forms of alpha-Co(III)-propargyl radical and gamma-Co(III)-allenyl radical. Alkenes 161-167 mitochondrially encoded cytochrome c oxidase II Homo sapiens 144-150 3406036-1 1988 A cytochrome P-450 LM2 reconstituted system mediated expoxidations of small terminal alkenes to the corresponding alkyloxiranes. Alkenes 85-92 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 2-18 34904988-3 2022 Over the past few decades, the addition of P-H bonds to alkenes, alkynes, arenes, heteroarenes and other unsaturated substrates in hydrophosphination and other related reactions via the above-mentioned catalytic processes has emerged as an atom economical approach to obtain organophosphorus compounds. Alkenes 56-63 phenylalanine hydroxylase Homo sapiens 43-46 2642041-0 1989 Cytochrome P-450-catalyzed asymmetric epoxidation of simple prochiral and chiral aliphatic alkenes: species dependence and effect of enzyme induction on enantioselective oxirane formation. Alkenes 91-98 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-16 35337621-9 2022 The redox active vitamin B12 derivatives shows a unique catalysis in the electroorganic synthesis, such as alkene and alkyne reductions. Alkenes 107-113 NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens 25-28 3250508-0 1988 Cytochrome P-450 model systems: alkene oxidation. Alkenes 32-38 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-16 3036459-12 1987 Furthermore, 5-lipoxygenase converts EPA to a pentene series of leukotrienes and the sulphidopeptide derivatives possess similar activity to their tetrameric counterparts. Alkenes 46-53 arachidonate 5-lipoxygenase Homo sapiens 13-27 3101178-4 1987 Desaturation of a nonactivated alkyl substituent represents a novel metabolic function of cytochrome P-450 and probably proceeds via the conversion of substrate to a transient free radical intermediate, which partitions between recombination (alcohol formation) and elimination (olefin production) pathways. Alkenes 279-285 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 90-106 16347505-1 1987 Eleven strains of alkene-utilizing bacteria belonging to the genera Mycobacterium, Nocardia, and Xanthobacter were tested for their ability to grow with C(1) to C(6) alkanes, C(2) to C(6) alkenes, alkadienes, and monoterpenes furnished individually as sole sources of carbon and energy in a mineral salts medium. Alkenes 18-24 heterogeneous nuclear ribonucleoprotein C Homo sapiens 153-157 16347505-1 1987 Eleven strains of alkene-utilizing bacteria belonging to the genera Mycobacterium, Nocardia, and Xanthobacter were tested for their ability to grow with C(1) to C(6) alkanes, C(2) to C(6) alkenes, alkadienes, and monoterpenes furnished individually as sole sources of carbon and energy in a mineral salts medium. Alkenes 18-24 complement C6 Homo sapiens 161-165 16347505-1 1987 Eleven strains of alkene-utilizing bacteria belonging to the genera Mycobacterium, Nocardia, and Xanthobacter were tested for their ability to grow with C(1) to C(6) alkanes, C(2) to C(6) alkenes, alkadienes, and monoterpenes furnished individually as sole sources of carbon and energy in a mineral salts medium. Alkenes 18-24 complement C2 Homo sapiens 175-179 16347505-1 1987 Eleven strains of alkene-utilizing bacteria belonging to the genera Mycobacterium, Nocardia, and Xanthobacter were tested for their ability to grow with C(1) to C(6) alkanes, C(2) to C(6) alkenes, alkadienes, and monoterpenes furnished individually as sole sources of carbon and energy in a mineral salts medium. Alkenes 18-24 complement C6 Homo sapiens 183-187 4084493-0 1985 Olefin oxygenation and N-dealkylation by dopamine beta-monooxygenase: catalysis and mechanism-based inhibition. Alkenes 0-6 dopamine beta-hydroxylase Homo sapiens 41-68 2870898-4 1986 It is likely, therefore, that the mechanism of action of these compounds is the same as that for allylisopropylacetamide (AIA) and related monosubstituted olefins, which are converted by cytochrome P-450 to chemically reactive species which bind covalently to the prosthetic heme moiety of the cytochrome and thereby destroy the enzyme. Alkenes 155-162 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 187-203 2870898-6 1986 These findings, together with data from related metabolic studies on AIA, support the view that the efficiency of the initial double bond oxidation reaction determines the extent of cytochrome P-450 destruction during the metabolism of terminal olefins, rather than any subsequent step. Alkenes 245-252 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 182-198 3707618-2 1986 The enzymic activation of a model olefin oct-1-ene was studied in rat liver microsomal systems in vitro. Alkenes 34-40 solute carrier family 22 member 1 Rattus norvegicus 41-46 6704124-1 1984 Aldehydes RCH2CHO are formed in addition to epoxides and allylic alcohols upon oxidation of the monosubstituted olefins RCH=CH2, styrene and 6-phenoxy-hex-1-ene, either by liver microsomal systems in the presence of NADPH and O2 or C6H5IO, or by iron-porphyrin- C6H5IO model systems. Alkenes 112-119 karyopherin subunit alpha 1 Homo sapiens 10-14 6587349-0 1984 Epoxidation of olefins by cytochrome P-450 model compounds: mechanism of oxygen atom transfer. Alkenes 15-22 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 26-42 6587349-5 1984 Some analogies to the biochemical epoxidation of olefins catalyzed by cytochrome P-450 are discussed. Alkenes 49-56 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 70-86 4053242-0 1985 Oxygen activation and olefin oxygenation by iron(III)porphyrin as a model of cytochrome P-450. Alkenes 22-28 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 77-93 3977318-2 1985 The inhibitory potency of each compound and its corresponding alkene precursor was determined with mouse liver EHs using [3H]-cis-stilbene oxide as substrate for microsomal EH (mEH) and for glutathione-S-transferase, and using [3H]-trans-stilbene oxide for cytosolic EH (cEH). Alkenes 62-68 epoxide hydrolase 1, microsomal Mus musculus 111-113 6652073-0 1983 Olefin oxidation by cytochrome P-450: evidence for group migration in catalytic intermediates formed with vinylidene chloride and trans-1-phenyl-1-butene. Alkenes 0-6 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 20-36 6833252-2 1983 Hepatic microsomal cytochrome P-450 from phenobarbital-pretreated rats is inactivated during the metabolism of linear olefins (ethylene, propene, and octene) and acetylenes (acetylene, propyne, and octyne). Alkenes 118-125 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 19-35 6833253-1 1983 Oxidation of 1-octene by cytochrome P-450 results concurrently in formation of 1,2-oxidooctane and in N-alkylation by the catalytically activated olefin of the prosthetic heme group. Alkenes 146-152 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 25-41 7082482-3 1982 The NADPH-request suggests that oxidative metabolism of this olefin by cytochrome P-450 is necessary for the observed destruction. Alkenes 61-67 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 71-87 6401984-5 1983 The above results establish the existence of a liver microsomal epoxide hydrolase that is under different regulatory control and that appears to have a different substrate specificity than the well-characterized microsomal epoxide hydrolase involved in the metabolism of a widely diverse group of alkene and arene oxides. Alkenes 297-303 epoxide hydrolase 1 Rattus norvegicus 53-81 6401984-5 1983 The above results establish the existence of a liver microsomal epoxide hydrolase that is under different regulatory control and that appears to have a different substrate specificity than the well-characterized microsomal epoxide hydrolase involved in the metabolism of a widely diverse group of alkene and arene oxides. Alkenes 297-303 epoxide hydrolase 1 Rattus norvegicus 212-240 118858-7 1979 The interface between plants and insects is enormous, and therefore it appears probable that cytochrome P-450 will one day be shown to be important in the conversion/utilization of other plant secondary substances, e.g., synthesis of cholesterol from phytosterols, and sex pheromones from olefins, terpenes, and alkaloids. Alkenes 289-296 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 93-109 6125350-1 1982 The stereochemistry of the metabolism of vic-dihaloalkanes to alkenes has been studied. Alkenes 62-69 endothelin 2 Rattus norvegicus 41-44 612461-0 1977 Dominant lethal studies with the halogenated olefins vinyl chloride and vinylidene dichloride in male CD-1 mice. Alkenes 45-52 CD1 antigen complex Mus musculus 102-106 4371119-0 1974 The inactivation of the acyl phosphatase activity catalyzed by the sulfenic acid form of glyceraldehyde 3-phosphate dehydrogenase by dimedone and olefins. Alkenes 146-153 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 89-129 33876158-3 2021 These complexes decompose via alkene elimination to give ThO2 without need for a secondary oxygen source. Alkenes 30-36 THO complex 2 Homo sapiens 57-61 14124905-0 1963 [THE EFFECT OF BLEACHING EARTH IN THE AUTO-OXIDATION OF OLEFIN FATS. Alkenes 56-62 chromosome 10 open reading frame 90 Homo sapiens 63-67 14124905-2 1963 ON DECREASE IN THE METAL CONTENT OF OLEFIN FATS BY COMBINED INSERTION OF ACTIVE ADSORPTION AGENTS AND METAL INACTIVATING COMPOUNDS]. Alkenes 36-42 chromosome 10 open reading frame 90 Homo sapiens 43-47 33949852-1 2021 A method for the acetoxyhydroxylation of olefins with syn stereoselectivity under electrophotocatalytic conditions is described. Alkenes 41-48 synemin Homo sapiens 54-57 33955226-2 2021 We describe a synthetic approach to strictosidine that relies on a key facially selective Diels-Alder reaction between a glucosyl-modified alkene and an enal to set the C15-C20-C21 stereotriad. Alkenes 139-145 placenta associated 8 Homo sapiens 169-172 33955226-2 2021 We describe a synthetic approach to strictosidine that relies on a key facially selective Diels-Alder reaction between a glucosyl-modified alkene and an enal to set the C15-C20-C21 stereotriad. Alkenes 139-145 TBL1X/Y related 1 Homo sapiens 177-180 33605521-0 2021 Slippage between eta2 and eta1 Coordination in Group 11 Borataalkene Complexes: Models for Alkene Activation. Alkenes 91-97 DNA polymerase iota Homo sapiens 17-21 33605521-0 2021 Slippage between eta2 and eta1 Coordination in Group 11 Borataalkene Complexes: Models for Alkene Activation. Alkenes 91-97 secreted phosphoprotein 1 Homo sapiens 26-30 33630396-0 2021 sp3 Bis-Organometallic Reagents via Catalytic 1,1-Difunctionalization of Unactivated Olefins. Alkenes 85-92 Sp3 transcription factor Homo sapiens 0-3 33890667-5 2021 ADS4.2 was highly expressed in young leaves, especially in trichomes, where the alkenes are known to accumulate. Alkenes 80-87 Fatty acid desaturase family protein Arabidopsis thaliana 0-4 33949420-2 2021 This work reports the "thiolene" click immobilization of heptakis(6-mercapto-6-deoxy)-beta-CD-CSP onto alkene functional silica to afford novel multiple-thioether bridged CD CSPs by controlling the surface CD concentration. Alkenes 103-109 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 86-93 33988384-0 2021 Rh(II)-Catalyzed C-H Alkylation of Benzylamines with Unactivated Alkenes: The Influence of Acid on Linear and Branch Selectivity. Alkenes 65-72 Rh blood group D antigen Homo sapiens 0-6 33875664-0 2021 Olefin oligomerization by main group Ga3+ and Zn2+ single site catalysts on SiO2. Alkenes 0-6 succinyl-CoA:glutarate-CoA transferase Homo sapiens 37-40 33875664-1 2021 In heterogeneous catalysis, olefin oligomerization is typically performed on immobilized transition metal ions, such as Ni2+ and Cr3+. Alkenes 28-34 teratocarcinoma-derived growth factor 1 pseudogene 3 Homo sapiens 129-132 33875664-2 2021 Here we report that silica-supported, single site catalysts containing immobilized, main group Zn2+ and Ga3+ ion sites catalyze ethylene and propylene oligomerization to an equilibrium distribution of linear olefins with rates similar to that of Ni2+. Alkenes 208-215 succinyl-CoA:glutarate-CoA transferase Homo sapiens 104-107 33427338-1 2021 We report the zirconium catalyzed hydroaminoalkylation of alkenes with N-aryl- and sterically demanding N-alkyl-alpha-arylated secondary amines using commercially available Zr(NMe2)4. Alkenes 58-65 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens 176-180 33875664-3 2021 The molecular weight distribution of products formed on Zn2+ is similar to Ni2+, while Ga3+ forms higher molecular weight olefins. Alkenes 122-129 succinyl-CoA:glutarate-CoA transferase Homo sapiens 87-90 33618159-6 2021 In the cases of the KPC-2 and VIM-2 structures, the THF ring is opened to give an alkene, but with L1 the THF ring remains intact. Alkenes 82-88 UBA domain containing 1 Homo sapiens 20-25 33618159-6 2021 In the cases of the KPC-2 and VIM-2 structures, the THF ring is opened to give an alkene, but with L1 the THF ring remains intact. Alkenes 82-88 vimentin 2, pseudogene Homo sapiens 30-35 33734679-5 2021 Subsequent Heck reaction and olefin metathesis compensate for the low efficiency with C1-1,4-dienes. Alkenes 29-35 aldo-keto reductase family 1 member C4 Homo sapiens 86-90 33492679-5 2021 The data obtained support a pre-catalyst activation step that gives access to an eta 2 -coordinated alkene Fe(I) complex, followed by oxidative addition of the alkene to give an Fe(III) intermediate, which then undergoes reductive elimination to allow release of the isomerization product. Alkenes 100-106 DNA polymerase iota Homo sapiens 81-86 33780588-2 2021 The use of newly-designed copper photocatalysts with B 2 Pin 2 permits the formation a boryl radical, which is used for hydroboration of a large panel of alkenes and alkynes. Alkenes 155-162 telomeric repeat binding factor 1 Homo sapiens 57-62 33689387-2 2021 The hydrosilylation proceeds via syn-addition of a Si-H bond to the alkyne group of 1,3-enynes, incorporating the silyl group at the site proximal to the alkene. Alkenes 154-160 synemin Homo sapiens 33-36 33709701-1 2021 The stereospecific, substrate (nitrogen source)-controlled intermolecular anti- and syn-1,2-diaminations of unactivated alkenes using the same catalysis (an iodine catalyst) is reported. Alkenes 120-127 synapsin I Homo sapiens 84-89 33527952-1 2021 The Cu(i)-catalyzed ring-opening cross-coupling of an oxabicyclic olefin with an organoboron reagent provides access to cis-2-aryl-1,2-dihydronaphthalen-1-ol derivatives, in contrast to the exclusive trans-selectivity in related Cu-catalyzed reactions with Grignard reagents. Alkenes 66-72 suppressor of cytokine signaling 2 Homo sapiens 120-125 33332670-6 2021 NMR chemical shifts of the olefins were investigated using two- and four-component relativistic DFT calculations, as spin-orbit effects can be large. Alkenes 27-34 spindlin 1 Homo sapiens 117-121 33596058-0 2021 Highly Z-Selective Double Bond Transposition in Simple Alkenes and Allylarenes through a Spin-Accelerated Allyl Mechanism. Alkenes 55-62 spindlin 1 Homo sapiens 89-93 33596058-3 2021 We report a beta-dialdiminate-supported, high-spin cobalt(I) complex that can convert terminal alkenes, including previously recalcitrant allylbenzenes, to Z-2-alkenes with unprecedentedly high regioselectivity and stereoselectivity. Alkenes 95-102 spindlin 1 Homo sapiens 46-50 33606532-2 2021 With the organic dye EY as an efficient photosensitizer and TPY-Fe(OTf)2 as the catalytic center, Hf-EY-Fe efficiently catalyzes aminotrifluoromethylation, hydroxytrifluoromethylation, and chlorotrifluoromethylation of alkenes. Alkenes 219-226 POU class 2 homeobox 2 Homo sapiens 60-72 33568646-2 2021 Herein, we report the nickel-catalyzed intermolecular cross-dialkylation of alkynes devoid of directing or activating groups to afford multiple aliphatic substituted alkenes in a syn-selective fashion at room temperature. Alkenes 166-173 synemin Homo sapiens 179-182 33179414-2 2021 The [Cu(OTf)] 2 -benzene catalyst that has been standard in this reaction for many decades, however, is air-sensitive, prone to photodecomposition, and is poorly reactive towards sterically bulky alkene substrates. Alkenes 196-202 POU class 2 homeobox 2 Homo sapiens 5-15 33560852-1 2021 A single-component Co(-I) catalyst, [(PPh3)3Co(N2)]Li(THF)3, has been developed for olefin hydroarylations with (N-aryl)aryl imine substrates. Alkenes 84-90 mitochondrially encoded cytochrome c oxidase I Homo sapiens 19-24 33497207-3 2021 An engineered variant of sperm whale myoglobin is shown to enable the highly diastereo- and enantioselective construction of these molecules via olefin cyclopropanation in the presence of a diazoketone carbene donor reagent. Alkenes 145-151 myoglobin Physeter catodon 37-46 33270337-4 2021 With three synergistic active sites, Hf12 -Ru-Co-OTf competently catalyzed dehydrogenative tandem transformations of indolines with alkenes or aldehydes to afford 3-alkylindoles and bisindolylmethanes with turnover numbers of up to 500 and 460, respectively, illustrating the potential use of MOLs in constructing novel multifunctional heterogeneous catalysts. Alkenes 132-139 zinc finger protein 3 Homo sapiens 37-41 33125815-5 2021 In contrast, both Co(II) and Co(III) complexes are also studied as catalysts to utilize air for olefin and alkane oxidation reactions, however not resulting in product formation. Alkenes 96-102 mitochondrially encoded cytochrome c oxidase II Homo sapiens 18-24 33300244-4 2021 Several experiments, including a deuterium scrambling study, revealed that olefin migration is catalyzed via an alkyl mechanism by in situ generated Pd-H species on the channel surface during photoirradiation. Alkenes 75-81 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 153-157 33125815-5 2021 In contrast, both Co(II) and Co(III) complexes are also studied as catalysts to utilize air for olefin and alkane oxidation reactions, however not resulting in product formation. Alkenes 96-102 mitochondrially encoded cytochrome c oxidase III Homo sapiens 29-36 32959513-1 2021 The earth-metal olefin complex [Ga I (COD) 2 ] + [Al(OR F ) 4 ] - (COD = 1,5-cyclooctadiene; R F = C(CF 3 ) 3 ) constitutes the first homoleptic olefin complex of any main-group metal accessible as a bulk compound. Alkenes 16-22 cortactin binding protein 2 Homo sapiens 50-61 32986927-3 2021 Herein, we report highly enantioselective intermolecular carboaminations of alkenes through C-H activation of N -phenoxyamides catalyzed by Co III -complexes equipped with chiral cyclopentadienyl (Cp x ) ligands. Alkenes 76-83 mitochondrially encoded cytochrome c oxidase III Homo sapiens 140-146 33376139-9 2021 We conclude that OhyA accelerates acid-catalyzed alkene hydration by positioning the fatty acid double bond to attack the active site hydronium ion, followed by the addition of water to the transient carbocation intermediate. Alkenes 49-55 AT695_RS03350 Staphylococcus aureus 17-21 33369436-2 2021 The reaction of alkenes or alkynes with Tf2O in the presence of CuX2 (X = Br, Cl), Zn powder, and 2,2"-bipyridine affords bromo(chloro)trifluoromethylated products in good yields. Alkenes 16-23 cut like homeobox 2 Homo sapiens 64-68 33146649-2 2020 In this study, we report our efforts to use tethered thioether ligands to tune the reactivity of RhII-carbene mediated cyclopropanation of olefins with ethyl diazoacetate. Alkenes 139-146 Rh blood group D antigen Homo sapiens 97-101 33342207-0 2021 NBS/DBU-Promoted One-Pot Three-Component Cycloaddition of Malonic Acid Derivatives, Nitrosoarenes, and Alkenes: Synthesis of Isoxazolidines. Alkenes 103-110 nibrin Homo sapiens 0-3 33342207-1 2021 A general DBU-mediated one-pot three-component cycloaddition reaction of easily accessible malonic acid derivatives, nitrosoarenes, and alkenes has been successfully established with the aid of NBS to provide direct access to highly functionalized isoxazolidine derivatives with generally good to excellent yields, broad functional group tolerance, and excellent regio- and diastereo-selectivities under mild conditions. Alkenes 136-143 nibrin Homo sapiens 194-197 33146532-1 2020 A light-driven atom-transfer radical substitution (ATRS) and carboesterification reaction of alkenes with alkyl halides has been developed using PTH as the organo-photoredox catalyst. Alkenes 93-100 parathyroid hormone Homo sapiens 145-148 33183714-7 2021 O3 formation analysis showed that reactive alkenes such as isoprene and cis-2-butene contributed most to O3 formation. Alkenes 43-50 suppressor of cytokine signaling 2 Homo sapiens 72-77 33125937-0 2021 The effect of PP contamination in recycled high-density polyethylene (rPE-HD) from post-consumer bottle waste and their compatibilization with olefin block copolymer (OBC). Alkenes 143-149 inorganic pyrophosphatase 1 Rattus norvegicus 14-16 33063079-3 2020 A mechanism is proposed for these cascade processes involving a sequential syn-chloropalladation or anti-acetoxypalladation of alkynes followed by intramolecular olefin insertion (6-exo-trig) and protonolysis steps. Alkenes 162-168 synemin Homo sapiens 75-78 32909759-0 2020 The Different Faces of [Ru(bpy)3Cl2] and fac[Ir(ppy)3] Photocatalysts: Redox Potential Controlled Synthesis of Sulfonylated Fluorenes and Pyrroloindoles from Unactivated Olefins and Sulfonyl Chlorides. Alkenes 170-177 FA complementation group C Homo sapiens 41-44 33214800-5 2020 After analyzing the pyrolysis product-semicoke (SC) and SO-with ATR-FTIR and GC-MS methods, CumNin/SA promotes the secondary cracking and aromatization of OS pyrolysis, increasing the content of the compound of olefins and aromatics in SO, and hastening the decomposition of long-chain aliphatic hydrocarbons to short-chain aliphatic hydrocarbons. Alkenes 211-218 acyl-CoA synthetase medium chain family member 3 Homo sapiens 92-101 32909759-0 2020 The Different Faces of [Ru(bpy)3Cl2] and fac[Ir(ppy)3] Photocatalysts: Redox Potential Controlled Synthesis of Sulfonylated Fluorenes and Pyrroloindoles from Unactivated Olefins and Sulfonyl Chlorides. Alkenes 170-177 insulin receptor Homo sapiens 45-53 32844841-8 2020 The recombination of beta-isobutanol radical with O2 forms a stabilized hydroperoxy alkyl radical below 400 K, water + an alkoxy radical at higher temperatures, and HO2 + an alkene above 1200 K. The recombination of beta-isobutanol radical with O2 results in a mixture of products between 700-1100 K, forming acetone + formaldehyde + OH at lower temperatures and forming HO2 + alkenes at higher temperatures. Alkenes 174-180 heme oxygenase 2 Homo sapiens 165-168 33066194-4 2020 Olefin-tethered cis-4-hydroxy-L-proline 1 and L-serine 2 and 8, and (R)-alpha-allyl-proline 18 were used as cross-linking motifs and incorporated into helical peptide sequences. Alkenes 0-6 suppressor of cytokine signaling 6 Homo sapiens 16-21 32938933-2 2020 Despite continuous advances in selective [2 + 2] cycloaddition research, general method for intermolecular photocatalysis of acyclic olefins with specific regio- and diastereoselectivity, for example, syn-head-to-head (syn-HH) cyclobutane derivatives, is still lack of development but highly desired. Alkenes 133-140 synemin Homo sapiens 201-204 32938933-2 2020 Despite continuous advances in selective [2 + 2] cycloaddition research, general method for intermolecular photocatalysis of acyclic olefins with specific regio- and diastereoselectivity, for example, syn-head-to-head (syn-HH) cyclobutane derivatives, is still lack of development but highly desired. Alkenes 133-140 synemin Homo sapiens 219-222 32786744-1 2020 A low-coordinate, high spin (S = 3/2) organometallic iron(I) complex is a catalyst for the isomerization of alkenes. Alkenes 108-115 spindlin 1 Homo sapiens 23-27 33043175-0 2020 Cp*Co(III)-Catalyzed C-H Hydroarylation of Alkynes and Alkenes and Beyond: A Versatile Synthetic Tool. Alkenes 55-62 mitochondrially encoded cytochrome c oxidase III Homo sapiens 3-10 33043175-4 2020 This perspective is focused on recent advances on the alkylation and alkenylation reactions of (hetero)arenes with alkenes and alkynes under Cp*Co(III) catalysis. Alkenes 115-122 mitochondrially encoded cytochrome c oxidase III Homo sapiens 144-151 32786744-4 2020 Since this spin state change is only possible when the alkene substrate is bound, the catalyst displays a high immunity to typical sigma-base poisons due to the antibonding interactions of the high spin state. Alkenes 55-61 spindlin 1 Homo sapiens 11-15 32786744-4 2020 Since this spin state change is only possible when the alkene substrate is bound, the catalyst displays a high immunity to typical sigma-base poisons due to the antibonding interactions of the high spin state. Alkenes 55-61 spindlin 1 Homo sapiens 198-202 32597654-4 2020 Two distinct readily available electrophiles, namely Csp2- and Csp3- halides are added simultaneously across a variety of olefins (vinyl amides, vinyl boranes, vinyl phosphates) at room temperature in a highly regio- and enantioselec-tive manner. Alkenes 122-129 regulator of calcineurin 2 Homo sapiens 53-57 32652311-1 2020 In contrast to other drug-metabolizing cytochrome P450 (CYP) oxygenases, CYP2J2 shows considerable extrahepatic activity and is responsible for the olefin epoxidation of several polyunsaturated fatty acid (PUFA) precursors. Alkenes 148-154 cytochrome P450 family 2 subfamily J member 2 Homo sapiens 73-79 32666790-1 2020 In this study, the carbohalogenation of olefins was accomplished by combining CBr4 and 2,2-bipyridyl under irradiation. Alkenes 40-47 carbonyl reductase 4 Homo sapiens 78-82 32806104-1 2020 The binaphthyl stabilized palladium nanoparticles (Pd-BNP) catalyzed single-step, stereoselective domino synthesis of symmetrically and unsymmetrically all-carbon tetrasubstituted olefin containing oxindoles from readily accessible anilides has been developed. Alkenes 180-186 natriuretic peptide B Homo sapiens 54-57 32659090-0 2020 Selective adsorption of C6, C8, and C10 linear alpha-olefins from binary liquid-phase olefin/paraffin mixtures using zeolite adsorbents: experiment and simulations. Alkenes 53-59 homeobox C10 Homo sapiens 36-39 32286794-13 2020 This catalytic strategy has thus enabled efficient difunctionalization of various alkenes and late-stage modification of complex biologically active molecules.In this Account, we describe a panoramic picture of our recent contributions since 2014 to the development and application of the visible-light-driven photoredox systems in the field of NCR chemistry. Alkenes 82-89 Neutrophil migration (granulocyte glycoprotein) Homo sapiens 345-348 32614175-4 2020 Remarkably, amino and pyridyl groups can be installed into both activated and unactivated alkenes with modular control of ortho-selectivity and 1,2-syn-diastereoselectivity under metal-free and mild conditions. Alkenes 90-97 synemin Homo sapiens 148-151 32456425-9 2020 Off-cycle olefin isomerization catalyzed by the same Co(-I) active species appears to be responsible for the observed Z-selectivity. Alkenes 10-16 mitochondrially encoded cytochrome c oxidase I Homo sapiens 53-58 32364370-1 2020 We investigated the adsorption properties of propylene and propane on olefin-selective Ag-X membrane and discussed the contribution of adsorption selectivity to propylene/propane separation performance through this membrane. Alkenes 70-76 UDP-N-acetylglucosamine pyrophosphorylase 1 Homo sapiens 87-91 31709663-1 2020 Zeise"s salt, KPt(C2H4)Cl3, was the first characterized organometallic compound; it was also the first olefin pi-complex. Alkenes 103-109 adhesion G protein-coupled receptor L3 Homo sapiens 18-26 32427846-4 2020 Extensive mechanistic studies suggest that the localized spin densities at sp2 carbons of alkenes account for the productive sensitization of alkenes despite their similar triplet levels of alkenes and alkynes. Alkenes 90-97 Sp2 transcription factor Homo sapiens 75-78 32427846-4 2020 Extensive mechanistic studies suggest that the localized spin densities at sp2 carbons of alkenes account for the productive sensitization of alkenes despite their similar triplet levels of alkenes and alkynes. Alkenes 142-149 Sp2 transcription factor Homo sapiens 75-78 32427846-4 2020 Extensive mechanistic studies suggest that the localized spin densities at sp2 carbons of alkenes account for the productive sensitization of alkenes despite their similar triplet levels of alkenes and alkynes. Alkenes 142-149 Sp2 transcription factor Homo sapiens 75-78 32293627-2 2020 (E)-1,2-Ditosylethene produces the expected and stable eta2-olefin palladium complexes, whereas the coordination of the Z derivative alternatively promotes the isomerization of the olefin itself or an oxidative addition process depending on the steric bulkiness of carbene substituents and/or the adopted synthetic procedure. Alkenes 60-66 DNA polymerase iota Homo sapiens 55-59 32348673-1 2020 We previously reported the development of an electron-deficient olefin (EDO) ligand, Fro-DO, that promotes the generation of quaternary carbon centers via Ni-catalyzed Csp3-Csp3 cross-coupling with aziridines. Alkenes 64-70 dishevelled binding antagonist of beta catenin 1 Homo sapiens 85-91 32202785-4 2020 Particularly, alkene-bridged derivative 12 exhibited remarkably potent cytotoxicity (IC50 = 0.22 nM on the MCF-7 cell line) and HIF-1 inhibition (IC50 = 0.09 nM), which considerably exceeded those of echinomycin. Alkenes 14-20 hypoxia inducible factor 1 subunit alpha Homo sapiens 128-133 32227871-2 2020 This is the first example of the direct coupling of alkene sp2 C-H bond and acetonitrile sp3 C-H bond for preparing beta,gamma-unsaturated nitriles. Alkenes 52-58 Sp2 transcription factor Homo sapiens 59-62 32227871-2 2020 This is the first example of the direct coupling of alkene sp2 C-H bond and acetonitrile sp3 C-H bond for preparing beta,gamma-unsaturated nitriles. Alkenes 52-58 Sp3 transcription factor Homo sapiens 89-92 32215426-0 2020 Transfer hydrogenation of alkynes into alkenes by ammonia borane over Pd-MOF catalysts. Alkenes 39-46 lysine acetyltransferase 8 Homo sapiens 73-76 32223198-1 2020 Here we describe a photoredox-catalyzed oxy-/aminofluoroalkylative cyclization of alkenes for coupling available Rf-I reagents to generate fluoroalkylated 2,3-dihydrobenzofuran and indolin derivatives with good to excellent yields under mild conditions. Alkenes 82-89 ring finger protein 34 Homo sapiens 113-117 32237734-6 2020 For example, an asymmetric alkene diarylation reaction developed by our group relies upon the radical properties of Ni(III) intermediates to control the enantioselectivity and give access to a library of chiral alpha,alpha,beta-triarylethane molecules with biological activity.Mechanistic studies on a two-component reductive 1,2-difunctionalization reaction have shed light on the origin of the cross-electrophile selectivity, as C sp2 and C sp3 electrophiles are independently activated at Ni(I) via two-electron and radical pathways, respectively. Alkenes 27-33 Sp2 transcription factor Homo sapiens 433-436 31903674-2 2020 Here we show that the one-pot combination of Ru1 /CeO2 and Rh1 /CeO2 SACs enables a highly selective olefin isomerization-hydrosilylation tandem process, hitherto restricted to molecular catalysts in solution. Alkenes 101-107 Scm like with four mbt domains 1 Homo sapiens 45-48 31981394-5 2020 The thin MOR nanosheets, with highly exposed (010) planes and 8-membered ring (MR) windows therein, exhibited an extremely higher ethylene selectivity (42.1%) for methanol-to-olefin reactions when compared with conventional bulk MOR crystals (3.3%). Alkenes 175-181 opioid receptor mu 1 Homo sapiens 9-12 31989122-3 2020 In particular, we show that the initial phase of the degradation involves the transformation of an alkane-type C-C bond into an alkene-type C[double bond, length as m-dash]C bond in the PFAS molecule, which is initiated by the trans elimination of fluorine atoms bonded to these adjacent carbon atoms. Alkenes 128-134 phosphoribosylformylglycinamidine synthase Homo sapiens 186-190 31967825-2 2020 In this report benzylic alcohols are shown to be effective radical precursors for addition reactions to alkenes when treated with triphenylphosphine or piperidine with the catalyst ReIO2(PPh3)2. Alkenes 104-111 caveolin 1 Homo sapiens 187-191 32108847-2 2020 The imidoyl-palladium intermediate generated by tandem indole double bond/isocyanide insertion reactions could be trapped by intramolecular functional groups such as the C(sp2)-H bond and alkenes, affording diversified indoline derivatives bearing C3 imine-containing heterocycles. Alkenes 188-195 Sp2 transcription factor Homo sapiens 170-175 32201792-3 2020 A new catalyst NiMoK/TS-1 was synthesized in which the effect of acidity of supports and molybdenum loading on the decarboxylation conversion along with product selectivity was investigated in methyl palmitate conversion into C15 olefin. Alkenes 230-236 placenta associated 8 Homo sapiens 226-229 32201792-6 2020 The NiMoK/TS-1 catalyst at a weight hourly space velocity (WHSV) of 5.6/h was found to be selective toward C15 olefin. Alkenes 111-117 placenta associated 8 Homo sapiens 107-110 32201792-8 2020 Beyond 653 K, the conversion of methyl palmitate increased but the selectivity for C15 products and C15 olefin was decreased. Alkenes 104-110 placenta associated 8 Homo sapiens 100-103 32109073-0 2020 Ruthenium-Catalyzed Regioselective Olefin Migration of Dihydropyran Acetals: A De Novo Strategy toward beta-2,6-Dideoxypyranoglycosides. Alkenes 35-41 ATPase H+ transporting V0 subunit a2 Homo sapiens 103-109 32017460-2 2020 We describe herein tandem olefin cross-metathesis/hemiacetalization/intramolecular oxa-Michael addition of allylic/homoallylic alcohols, a,b-unsaturated ketones, and aldehydes, which enabled the synthesis of syn -1,2- and syn -1,3-diol derivatives in a step-economical manner. Alkenes 26-32 synapsin I Homo sapiens 208-217 31944119-0 2020 Metal-Free Catalyzed Synthesis of Allyl Nitriles via Csp2-Csp3 Coupling between Olefins and Azobis (alkyl-carbonitrile). Alkenes 80-87 regulator of calcineurin 2 Homo sapiens 53-57 31944119-1 2020 The metal-free catalyzed synthesis of allyl nitriles from Csp2-Csp3 coupling between olefins and azobis was developed. Alkenes 85-92 regulator of calcineurin 2 Homo sapiens 58-62 31971800-2 2020 A range of O-perfluoropyridin-4-yl oximes were successfully utilized in C(sp2)-C(sp3) bond formations of quinoxalin-2(1H)-ones and alkenes, providing facile accesses to a range of functionalized alkylnitriles. Alkenes 131-138 Sp2 transcription factor Homo sapiens 72-77 31568571-6 2020 Topological analysis shows that there is a five-membered ring plane structure in the reaction pathway and that the final product (E)-Pro belongs to a typical eta2 -olefin monohydride complex. Alkenes 164-182 DNA polymerase iota Homo sapiens 158-162 31999132-1 2020 Malonoyl peroxide 6 is an effective reagent for the syn- or anti-oxyamination of alkenes. Alkenes 81-88 synemin Homo sapiens 52-55 31691388-4 2020 This results in a simple and broadly applicable overall protocol to stereoselectively access E -alkenes employing H 2 which could serve as a general method for synthesis. Alkenes 96-103 relaxin 2 Homo sapiens 114-117 31913377-1 2020 We report the influence of N-heterocyclic carbenes (NHCs) on the hydrolysis of a diphosphene TerP[double bond, length as m-dash]PTer (1; Ter = 2,6-Mes2C6H3; Mes = 2,4,6-Me3C6H2), a phosphorus-analogue of an alkene. Alkenes 207-213 peroxisomal trans-2-enoyl-CoA reductase Homo sapiens 93-97 31820914-12 2020 We also switched the positions of the alkene and the alkyne in the 1,4-enyne of our original ACE to provide an inverted ACE variant, which produced products with complementary functionalities. Alkenes 38-44 angiotensin I converting enzyme Homo sapiens 93-96 31820914-12 2020 We also switched the positions of the alkene and the alkyne in the 1,4-enyne of our original ACE to provide an inverted ACE variant, which produced products with complementary functionalities. Alkenes 38-44 angiotensin I converting enzyme Homo sapiens 120-123 31944775-0 2020 Photoinduced C(sp2)-H/C(sp2)-H Cross-Coupling of Alkenes: Direct Synthesis of 1,3-Dienes. Alkenes 49-56 Sp2 transcription factor Homo sapiens 13-18 31944775-0 2020 Photoinduced C(sp2)-H/C(sp2)-H Cross-Coupling of Alkenes: Direct Synthesis of 1,3-Dienes. Alkenes 49-56 Sp2 transcription factor Homo sapiens 22-27 31927888-1 2020 For the first time, an intermolecular iodotrifluoromethoxylation between alkenes and NIS with AgF as catalyst and TFMS as trifluoromethoxylation reagent has been explored. Alkenes 73-80 angiopoietin like 6 Homo sapiens 94-97 31963848-5 2020 Thus, in this paper, we report a simple synergistic integration of the cell trapping of microwell chip and gold-capped nanopillar-structured cyclo-olefin-polymer (COP) film for single cell level Interleukin 6 (IL-6) detection. Alkenes 141-153 interleukin 6 Homo sapiens 195-208 31963848-5 2020 Thus, in this paper, we report a simple synergistic integration of the cell trapping of microwell chip and gold-capped nanopillar-structured cyclo-olefin-polymer (COP) film for single cell level Interleukin 6 (IL-6) detection. Alkenes 141-153 interleukin 6 Homo sapiens 210-214 33479630-3 2020 Here we describe the development of a series of macrocyclic IRAP inhibitors with either disulphide, olefin metathesis or lactam bridges and variations of ring size and other functionality. Alkenes 100-106 leucyl and cystinyl aminopeptidase Homo sapiens 60-64 32943150-4 2020 These strategies are effective for imparting these myoglobin-based cyclopropanation biocatalysts with altered and improved function, including tolerance to aerobic conditions and improved reactivity toward electrondeficient olefins. Alkenes 224-231 myoglobin Homo sapiens 51-60 31709435-1 2019 High molecular weight polyglycerol-dendronized poly(norbornene)s (PGD-PNBs) were prepared via ring-opening metathesis polymerization of norbornene monomers containing amine functional groups on the side-chains followed by dendron growth from the olefins of PNB backbones using iterative dihydroxylation and allylation. Alkenes 246-253 phosphoglycerate dehydrogenase Homo sapiens 66-69 32713539-2 2020 A two-step procedure is presented in which a strained alkene chemical reporter is inserted into any desired location within the GPCR in the first step, followed by a robust bioorthogonal ligation reaction with a fluorophore-conjugated tetrazine or tetrazole reagent in the second step. Alkenes 54-60 G protein-coupled receptor 166 pseudogene Homo sapiens 128-132 32713539-4 2020 Subsequently, the inverse electron-demand Diels-Alder reaction with an AF647-conjugated 3,6-di (2-pyridyl)-S-tetrazine (DpTz) was performed with the alkene-encoded GCGR on live-cell surface. Alkenes 149-155 glucagon receptor Homo sapiens 164-168 31765121-16 2019 For elementary steps of the industrially important methanol-to-olefin process, our hybrid MP2:PBE+D+DeltaCC calculations yield rate constants in agreement with experiment within chemical accuracy limits, finally achieving for molecule-surface reactions which was possible so hitherto only for gas phase reactions involving not more than 10 atoms. Alkenes 63-69 tryptase pseudogene 1 Homo sapiens 90-93 31926628-0 2020 Complex interrelationships between nitro-alkene-dependent inhibition of soluble epoxide hydrolase, inflammation and tumor growth. Alkenes 35-47 epoxide hydrolase 2, cytoplasmic Mus musculus 72-97 31661951-7 2019 High olefin to paraffin ratio was achieved for C2 to C11 products, where the ratio for C3 was higher than 10. Alkenes 5-11 aldo-keto reductase family 1 member C4 Homo sapiens 53-56 31842451-4 2019 Olefin cross metathesis between allyl beta-C-galactopyranosyl and 1-vinylnaphthalenes or acylation of aminomethyl beta-C-galactopyranosyl with 1-naphthoic acid derivatives gave C-galactopyranosyls carrying 1-naphthamide structural elements that interacted favorably with a galectin-3 unique subsite according to molecular modeling and X-ray structural analysis of two inhibitor-galectin-3 complexes. Alkenes 0-6 galectin 3 Homo sapiens 273-283 31842451-4 2019 Olefin cross metathesis between allyl beta-C-galactopyranosyl and 1-vinylnaphthalenes or acylation of aminomethyl beta-C-galactopyranosyl with 1-naphthoic acid derivatives gave C-galactopyranosyls carrying 1-naphthamide structural elements that interacted favorably with a galectin-3 unique subsite according to molecular modeling and X-ray structural analysis of two inhibitor-galectin-3 complexes. Alkenes 0-6 galectin 3 Homo sapiens 378-388 31483477-4 2019 The latest creation of a serine-ligated mutant of BM3 showed an efficient transfer of reactive carbenes into C C bonds of olefins reaching total turnover numbers (TTNs) of more than 60,000 and product titers of up to 27 g L-1 . Alkenes 122-129 immunoglobulin kappa variable 1-16 Homo sapiens 222-225 31517412-0 2019 Unusual eta1-Coordinated Alkyne and Alkene Complexes. Alkenes 36-42 secreted phosphoprotein 1 Homo sapiens 8-12 31517412-3 2019 Analogous eta 1 -coordinated alkene complexes are also predicted, and they are promising for applications to the important olefin polymerization reaction. Alkenes 29-35 secreted phosphoprotein 1 Homo sapiens 10-15 31517412-3 2019 Analogous eta 1 -coordinated alkene complexes are also predicted, and they are promising for applications to the important olefin polymerization reaction. Alkenes 123-129 secreted phosphoprotein 1 Homo sapiens 10-15 31742399-0 2019 Catalytic, Enantioselective syn-Diamination of Alkenes. Alkenes 47-54 synemin Homo sapiens 28-31 31742399-3 2019 In this article, we describe the first enantioselective, syn-diamination of simple alkenes mediated by a chiral, enantioenriched organoselenium catalyst together with a N,N"-bistosyl urea as the bifunctional nucleophile and N-fluorocollidinium tetrafluoroborate as the stoichiometric oxidant. Alkenes 83-90 synemin Homo sapiens 57-60 31742399-6 2019 Furthermore, the syn-stereospecificity of the transformation shows promise for highly enantioselective diaminations of alkenes with no strong steric or electronic bias. Alkenes 119-126 synemin Homo sapiens 17-20 31609611-2 2019 Abstract DFT calculations (B3LYP/6-311+G(d,p) )have been employed to reexamine the mechanism of the oxidation of saturated hydrocarbons and the epoxidation of alkenes with a series of hydroperoxides, alpha-hydroxy perhydrates and peroxyacids. Alkenes 159-166 protein tyrosine phosphatase non-receptor type 22 Homo sapiens 29-32 31687825-1 2019 The anti-Markovnikov hydrosulfonylation of unactivated alkenes with sodium sulfinates was realized via [Ir(dF(CF3)ppy)2(dtbbpy)]PF6-mediated visible light photoredox catalysis. Alkenes 55-62 sperm associated antigen 17 Homo sapiens 128-131 31538388-0 2019 Pd(0)-Catalyzed Directed syn-1,2-Carboboration and -Silylation: Alkene Scope, Applications in Dearomatization, and Stereocontrol via a Chiral Auxiliary. Alkenes 64-70 synapsin I Homo sapiens 25-30 31538388-1 2019 We report the development of palladium(0)-catalyzed syn -selective 1,2-carboboration and -silylation reactions of alkenes containing cleavable directing groups. Alkenes 114-121 synemin Homo sapiens 52-55 31306498-6 2019 Similarly, heterologous expression of TaCER1-1A in Arabidopsis wild type and the cer1 mutant resulted in increased levels of unbranched alkanes, iso-branched alkanes and alkenes. Alkenes 170-177 Fatty acid hydroxylase superfamily Arabidopsis thaliana 81-85 31659376-6 2019 In general, fluorotelomer olefins (FTOs) ionized in negative-ion APCI and APPI generated the molecular ion, while fluorotelomer alcohols (FTOHs) also provided the deprotonated molecule. Alkenes 12-33 amyloid beta precursor protein Homo sapiens 74-78 31659376-6 2019 In general, fluorotelomer olefins (FTOs) ionized in negative-ion APCI and APPI generated the molecular ion, while fluorotelomer alcohols (FTOHs) also provided the deprotonated molecule. Alkenes 35-39 amyloid beta precursor protein Homo sapiens 74-78 31638402-0 2019 Cobalt-Catalyzed C(sp2)-H Allylation of Biphenyl Amines with Unbiased Terminal Olefins. Alkenes 79-86 Sp2 transcription factor Homo sapiens 17-22 31625380-3 2019 Here, we show, using the oxidation of alkenes with H2O2 and the catalyst [Mn2(mu-O)3(tmtacn)2](PF6)2 (1), that Lewis acids commonly used to enhance catalytic activity, e.g., Sc(OTf)3, in fact undergo hydrolysis with adventitious water to release a strong Bronsted acid. Alkenes 38-45 POU class 5 homeobox 1 Homo sapiens 174-182 31389697-0 2019 Visible-Light-Induced Trifluoromethylation of Unactivated Alkenes with Tri(9-anthryl)borane as an Organophotocatalyst. Alkenes 58-65 tRNA-Ile (anticodon AAT) 9-1 Homo sapiens 22-25 31432578-0 2019 6-Methylenebicyclo[3.2.1]oct-1-en-3-one: Twisted Olefin as Diels-Alder Dienophile for Expedited Syntheses of Four Kaurane Diterpenoids. Alkenes 49-55 solute carrier family 22 member 1 Homo sapiens 25-30 31389697-1 2019 Tri(9-anthryl)borane was successfully applied as an organophotocatalyst for the visible-light-induced trifluoromethylation of unactivated alkenes with CF3I. Alkenes 138-145 tRNA-Ile (anticodon AAT) 9-1 Homo sapiens 0-3 31557043-1 2019 Aerobic Pd(AcO)2/pyridine-catalyzed oxidation of unprotected carbohydrate-based terminal alkenes was studied. Alkenes 89-96 aconitase 2 Homo sapiens 11-16 31565935-2 2019 The protocol is characterized by its mild conditions, wide scope, including the use of ethylene as substrate, and exquisite site-selectivity pattern for both alpha-olefins and internal olefins, thus unlocking a new catalytic platform to forge sp3-sp3 linkages, even in the context of late-stage functionalization. Alkenes 158-171 Sp3 transcription factor Homo sapiens 243-246 31589451-1 2019 A range of Ru-, Rh-, or Pd-catalyzed vinylic C-H/C-H cross-coupling reactions of olefins have been demonstrated to provide 1,3-dienes, using a quantitative amount of metal oxidants. Alkenes 81-88 churchill domain containing 1 Homo sapiens 45-52 31565935-2 2019 The protocol is characterized by its mild conditions, wide scope, including the use of ethylene as substrate, and exquisite site-selectivity pattern for both alpha-olefins and internal olefins, thus unlocking a new catalytic platform to forge sp3-sp3 linkages, even in the context of late-stage functionalization. Alkenes 158-171 Sp3 transcription factor Homo sapiens 247-250 31565935-2 2019 The protocol is characterized by its mild conditions, wide scope, including the use of ethylene as substrate, and exquisite site-selectivity pattern for both alpha-olefins and internal olefins, thus unlocking a new catalytic platform to forge sp3-sp3 linkages, even in the context of late-stage functionalization. Alkenes 164-171 Sp3 transcription factor Homo sapiens 243-246 31565935-2 2019 The protocol is characterized by its mild conditions, wide scope, including the use of ethylene as substrate, and exquisite site-selectivity pattern for both alpha-olefins and internal olefins, thus unlocking a new catalytic platform to forge sp3-sp3 linkages, even in the context of late-stage functionalization. Alkenes 164-171 Sp3 transcription factor Homo sapiens 247-250 31461210-3 2019 The olefin pairs of the spacer ligands, which resemble a ladder-like structure, in the MOF, undergo a [2+2] cycloaddition reaction in a single-crystal-to-single-crystal manner. Alkenes 4-10 lysine acetyltransferase 8 Homo sapiens 87-90 31498619-0 2019 Syn-Dihydroxylation of Alkenes Using A Sterically Demanding Cyclic Diacyl Peroxide. Alkenes 23-30 synemin Homo sapiens 0-3 31513388-1 2019 Oxoiron(IV) is a common catalytic byproduct observed in the oxidation of alkenes by the combination of H2O2 and nonheme iron catalysts including complex 1, FeIIPDP* (where PDP* = bis(3,5-dimethyl-4-methoxypyridyl-2-methyl)-(R,R)-2,2"-bipyrrolidine). Alkenes 73-80 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 160-164 31498619-1 2019 The syn-dihydroxylation of alkenes is a highly valuable reaction in organic synthesis. Alkenes 27-34 synemin Homo sapiens 4-7 31498619-3 2019 Here we demonstrate that the structurally demanding cyclic peroxide spiro[bicyclo[2.2.1]heptane-2,4"-[1,2]dioxolane]-3",5"-dione (P4) can be effectively used for the syn-dihydroxylation of alkenes. Alkenes 189-196 solute carrier family 10 member 4 Homo sapiens 130-132 31498619-3 2019 Here we demonstrate that the structurally demanding cyclic peroxide spiro[bicyclo[2.2.1]heptane-2,4"-[1,2]dioxolane]-3",5"-dione (P4) can be effectively used for the syn-dihydroxylation of alkenes. Alkenes 189-196 synemin Homo sapiens 166-169 31498619-4 2019 Reagent P4 also shows an improved selectivity for dihydroxylation of alkenes bearing beta-hydrogens as compared to other CAPs, where both diol and allyl alcohol products compete with each other. Alkenes 69-76 solute carrier family 10 member 4 Homo sapiens 8-10 31498619-5 2019 Furthermore, the use of enantiopure P4 (labeled P4") demonstrates the potential of P4" for a metal-free asymmetric syn-dihydroxylation of alkenes. Alkenes 138-145 solute carrier family 10 member 4 Homo sapiens 36-38 31498619-5 2019 Furthermore, the use of enantiopure P4 (labeled P4") demonstrates the potential of P4" for a metal-free asymmetric syn-dihydroxylation of alkenes. Alkenes 138-145 solute carrier family 10 member 4 Homo sapiens 48-50 31498619-5 2019 Furthermore, the use of enantiopure P4 (labeled P4") demonstrates the potential of P4" for a metal-free asymmetric syn-dihydroxylation of alkenes. Alkenes 138-145 solute carrier family 10 member 4 Homo sapiens 48-50 31498619-5 2019 Furthermore, the use of enantiopure P4 (labeled P4") demonstrates the potential of P4" for a metal-free asymmetric syn-dihydroxylation of alkenes. Alkenes 138-145 synemin Homo sapiens 115-118 31333021-6 2019 In studies of manganese catalysts, the aryl-substituted (R,R)-mcp [mcp = N,N"-dimethyl-N,N"-bis(pyridine-2-ylmethyl)cyclohexane-1,2-diamine] manganese complexes exhibited high enantioselectivity in the asymmetric epoxidation (AE) of various olefins with H2O2 while requiring stoichiometric acetic acid as an additive for the activation of H2O2. Alkenes 241-248 CD46 molecule Homo sapiens 62-65 31364653-0 2019 Stereodivergent synthesis of alkenes by controllable syn-/anti-fragmentation of beta-hydroxysulfonyl intermediates. Alkenes 29-36 synemin Homo sapiens 16-19 31398017-0 2019 Mechanistic Insight into Synergistic Catalysis of Olefin Hydrogenation by a Hetero-Dinuclear RuII-CoII Complex with Adjacent Reaction Sites. Alkenes 50-56 mitochondrially encoded cytochrome c oxidase II Homo sapiens 98-102 31398017-2 2019 A synergistic effect between the adjacent RuII and CoII sites has been confirmed in catalytic olefin hydrogenation by the complex, exhibiting a much higher turnover number than those of mononuclear RuII or CoII complexes as the components. Alkenes 94-100 mitochondrially encoded cytochrome c oxidase II Homo sapiens 51-55 31398017-2 2019 A synergistic effect between the adjacent RuII and CoII sites has been confirmed in catalytic olefin hydrogenation by the complex, exhibiting a much higher turnover number than those of mononuclear RuII or CoII complexes as the components. Alkenes 94-100 mitochondrially encoded cytochrome c oxidase II Homo sapiens 206-210 31514502-2 2019 We found that rhodium-carbynoid species provoke C(sp2)-C(sp2) bond scission in alkenes by inserting a monovalent carbon unit between both sp2-hybridized carbons. Alkenes 79-86 Sp2 transcription factor Homo sapiens 48-53 31514502-2 2019 We found that rhodium-carbynoid species provoke C(sp2)-C(sp2) bond scission in alkenes by inserting a monovalent carbon unit between both sp2-hybridized carbons. Alkenes 79-86 Sp2 transcription factor Homo sapiens 55-60 31514502-2 2019 We found that rhodium-carbynoid species provoke C(sp2)-C(sp2) bond scission in alkenes by inserting a monovalent carbon unit between both sp2-hybridized carbons. Alkenes 79-86 Sp2 transcription factor Homo sapiens 50-53 31329323-1 2019 An operationally simple method to affect an atom-transfer radical addition of commercially available ICH2 Bpin to terminal alkenes has been developed. Alkenes 123-130 caspase 4 Homo sapiens 101-105 31403304-1 2019 A zirconium catalyzed reductive cleavage of Csp3 and Csp2 carbon-heteroatom bonds is reported that makes use of a tethered alkene functionality as a traceless directing group. Alkenes 123-129 regulator of calcineurin 2 Homo sapiens 53-57 31221388-6 2019 Biomass boiler 1 (BB1) emitted relatively high proportions of alkanes (28.9%-38.1% by mass) and alkenes and acetylenes (23.4%-40.8%), while biomass boiler 2 (BB2) emitted relatively high proportions of aromatics (27.9%-29.2%) and oxygenated VOCs (33.0%-44.8%). Alkenes 96-103 neuromedin B receptor Homo sapiens 18-21 31333021-6 2019 In studies of manganese catalysts, the aryl-substituted (R,R)-mcp [mcp = N,N"-dimethyl-N,N"-bis(pyridine-2-ylmethyl)cyclohexane-1,2-diamine] manganese complexes exhibited high enantioselectivity in the asymmetric epoxidation (AE) of various olefins with H2O2 while requiring stoichiometric acetic acid as an additive for the activation of H2O2. Alkenes 241-248 CD46 molecule Homo sapiens 67-70 31322353-2 2019 Aldehydes were homolytically cleavaged to produce acyl radicals and subsequently allowed for the successive construction of C(sp2)-C(sp3), C(sp3)-C(sp3), and C(sp3)-O bonds via dual radical insertions and radical-radical coupling, following the intrinsic nucleo/electrophilic reactivity of both the radicals and alkenes. Alkenes 312-319 Sp2 transcription factor Homo sapiens 124-129 31391519-4 2019 Furthermore, the PEBAX-5513/AgBF4/Al(NO3)3 membranes had long-term stability because of Al(NO3) to have the stabilizing effect on Ag+ ions acting as an olefin carrier. Alkenes 152-158 NBL1, DAN family BMP antagonist Homo sapiens 37-40 31391519-8 2019 Since the ratio of amide was high, Ag+ ions were favorably in coordination with the oxygen of the carbonyl group, but the NO3- ions in Al(NO3)3 had the enhanced interaction with Ag+ ions as obstacles for olefin complexation. Alkenes 204-210 NBL1, DAN family BMP antagonist Homo sapiens 122-125 31391519-8 2019 Since the ratio of amide was high, Ag+ ions were favorably in coordination with the oxygen of the carbonyl group, but the NO3- ions in Al(NO3)3 had the enhanced interaction with Ag+ ions as obstacles for olefin complexation. Alkenes 204-210 NBL1, DAN family BMP antagonist Homo sapiens 138-141 31283210-2 2019 With Cu(OTf)2 as the catalyst, the reaction of alkenes, (bpy)Zn(CF3)2, and N-fluorobis(benzenesulfonyl)imide (NFSI) at room temperature provides the corresponding aminotrifluoromethylation products in satisfactory yields with high regioselectivity opposite to those driven by CF3 radical addition. Alkenes 47-54 POU class 2 homeobox 2 Homo sapiens 5-13 31322875-2 2019 Due to the electronic bias of the pi-alkene-palladium complexes, nucleopalladations with terminal aliphatic alkenes typically deliver the nucleophile to the more substituted sp2 carbon to form the Markovnikov-selective products. Alkenes 37-43 Sp2 transcription factor Homo sapiens 174-177 31322875-2 2019 Due to the electronic bias of the pi-alkene-palladium complexes, nucleopalladations with terminal aliphatic alkenes typically deliver the nucleophile to the more substituted sp2 carbon to form the Markovnikov-selective products. Alkenes 108-115 Sp2 transcription factor Homo sapiens 174-177 31339319-2 2019 Under the optimized conditions using [Ru(bpy)3(PF6)2] as the photocatalyst, a wide range of terminal and internal alkenes can efficiently undergo azidoalkoxy-trifluoromethylation in the presence of Umemoto"s reagent, carbonyl compound, and TMSN3, giving rise to original and highly complex molecules in a single operation. Alkenes 114-121 sperm associated antigen 17 Homo sapiens 47-50 31260303-6 2019 2-Oxo-3-enoates also underwent addition to olefins in the presence of Ru(phen)3(PF6)2. Alkenes 43-50 sperm associated antigen 17 Homo sapiens 80-83 30827993-2 2019 When p-toluenethiol was added to CA 1, the FT-IR spectra revealed a cleavage of alkene caused by the addition reaction between p-toluenethiol and CA 1. Alkenes 80-86 carbonic anhydrase 1 Homo sapiens 33-37 31215581-0 2019 The role of olefin geometry in the activity of hydrocarbon stapled peptides targeting eukaryotic translation initiation factor 4E (eIF4E). Alkenes 12-18 eukaryotic translation initiation factor 4E Homo sapiens 86-129 31215581-0 2019 The role of olefin geometry in the activity of hydrocarbon stapled peptides targeting eukaryotic translation initiation factor 4E (eIF4E). Alkenes 12-18 eukaryotic translation initiation factor 4E Homo sapiens 131-136 31215581-4 2019 By applying this HCS to the disordered peptide eIF4E-binding protein 1 (4E-BP1), we discovered that this type of tethering has a dramatic effect on olefin geometry and activity of the resultant stapled peptides, where the putative trans isomer was found to exhibit enhanced in vitro and cellular inhibitory activity against eIF4E protein-protein interactions. Alkenes 148-154 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 47-70 31215581-4 2019 By applying this HCS to the disordered peptide eIF4E-binding protein 1 (4E-BP1), we discovered that this type of tethering has a dramatic effect on olefin geometry and activity of the resultant stapled peptides, where the putative trans isomer was found to exhibit enhanced in vitro and cellular inhibitory activity against eIF4E protein-protein interactions. Alkenes 148-154 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 72-78 31215581-4 2019 By applying this HCS to the disordered peptide eIF4E-binding protein 1 (4E-BP1), we discovered that this type of tethering has a dramatic effect on olefin geometry and activity of the resultant stapled peptides, where the putative trans isomer was found to exhibit enhanced in vitro and cellular inhibitory activity against eIF4E protein-protein interactions. Alkenes 148-154 eukaryotic translation initiation factor 4E Homo sapiens 47-52 30827993-2 2019 When p-toluenethiol was added to CA 1, the FT-IR spectra revealed a cleavage of alkene caused by the addition reaction between p-toluenethiol and CA 1. Alkenes 80-86 carbonic anhydrase 1 Homo sapiens 146-150 31001984-0 2019 Palladium-Catalyzed Regioselective Syn-Chloropalladation-Olefin Insertion-Oxidative Chlorination Cascade: Synthesis of Dichlorinated Tetrahydroquinolines. Alkenes 57-63 synemin Homo sapiens 35-38 31189060-10 2019 Consequently, we concluded that the DH mechanism is adopted as the mechanism for the Rh-catalyzed hydrosilylation of the carbonyl group while the mCH or DH mechanism is adopted as the mechanism for alkenes under conditions where their active intermediates are formed. Alkenes 198-205 modifier of chinchilla Mus musculus 146-149 31768077-0 2019 Organoselenium-catalyzed enantioselective syn-dichlorination of unbiased alkenes. Alkenes 73-80 synemin Homo sapiens 42-45 31070908-1 2019 Transfers of carbene moieties to heterocycles or cyclic alkenes to obtain C(sp2)-H alkylation or cyclopropane products are valuable transformations for synthesis of pharmacophores and chemical building blocks. Alkenes 56-63 Sp2 transcription factor Homo sapiens 74-79 31070219-0 2019 Co(iii)-catalyzed Z-selective oxidative C-H/C-H cross-coupling of alkenes with triisopropylsilylacetylene. Alkenes 66-73 churchill domain containing 1 Homo sapiens 40-47 31086887-0 2019 PdCl2(CH3CN)2-catalyzed regioselective C-H olefinations of 2-amino biaryls with vinylsilanes as unactivated alkenes. Alkenes 108-115 phosducin like 2 Homo sapiens 0-5 31045379-0 2019 Stereoselective Tandem Synthesis of syn-1,3-Diol Derivatives by Integrating Olefin Cross-Metathesis, Hemiacetalization, and Intramolecular Oxa-Michael Addition. Alkenes 76-82 synapsin I Homo sapiens 36-41 31045379-2 2019 Olefin cross-metathesis of homoallylic alcohols with alpha,beta-unsaturated ketones, hemiacetalization of the resultant alcohols with aldehydes, and subsequent intramolecular oxa-Michael addition of the derived hemiacetals furnished syn-1,3-dioxane derivatives in good to excellent yields without isolation of any intermediates. Alkenes 0-6 synapsin I Homo sapiens 233-238 31163697-3 2019 Notably, one similar fragment, where the amide moiety replaces the trans alkene moiety, appears in Psammaplin A, another marine natural product with potent HDAC inhibitory activities. Alkenes 73-79 histone deacetylase 9 Homo sapiens 156-160 31020971-1 2019 The readily-accessible, air-stable Lewis acid [(terpy)PPh][B(C6F5)4]21 is shown to mediate the hydrosilylation of aldehydes, ketones, and olefins. Alkenes 138-145 enolase 1 Homo sapiens 54-57 31072012-0 2019 Unprecedentedly High Activity and/or High Regio-/Stereoselectivity of Fluorenyl-Based CGC Allyl-Type eta3:eta1-tert-Butyl(dimethylfluorenylsilyl)amido Ligated Rare Earth Metal Monoalkyl Complexes in Olefin Polymerization. Alkenes 199-205 secreted phosphoprotein 1 Homo sapiens 106-110 31001984-1 2019 A palladium catalyzed cascade process involving syn-chloropalladation, intramolecular olefin insertion, and oxidative C-Cl bond formation reactions was demonstrated for the synthesis of dichlorinated tetrahydroquinolines in high yields (up to 93%). Alkenes 86-92 synemin Homo sapiens 48-51 31133770-4 2019 In addition, substitution of the proximal histidine with an aspartate residue led to a myoglobin-based catalyst capable of promoting stereoselective olefin cyclopropanation under nonreducing conditions. Alkenes 149-155 myoglobin Homo sapiens 87-96 30839151-3 2019 Incorporation of both CN and HCF2 into organic molecules, such as alkenes, is a worthwhile but challenging task. Alkenes 66-73 host cell factor C2 Homo sapiens 29-33 30789171-0 2019 Computational and experimental investigation on the BCl3 promoted intramolecular amination of alkenes and alkynes. Alkenes 94-101 BCL3 transcription coactivator Homo sapiens 52-56 30888189-1 2019 The insertion of lithiated epoxides into boronic esters followed by thermal syn-elimination provides a stereospecific entry to alkenes. Alkenes 127-134 synemin Homo sapiens 76-79 30896184-0 2019 Copper-Catalyzed Radical Selenodifluoromethylation of Alkenes: Access to CF2-Containing gamma-Lactams. Alkenes 54-61 ATPase H+ transporting accessory protein 1 Homo sapiens 73-76 30648294-1 2019 The anti-Markovnikov hydroazidation of alkenes has been accomplished under visible-light irradiation by using [Ir(dF(CF3 )ppy)2 (dtbbpy)]PF6 as the photocatalyst and trimethylsilyl azide as the azidating agent. Alkenes 39-46 sperm associated antigen 17 Homo sapiens 137-140 30835931-5 2019 Spectroscopic and spectroelectrochemical investigations indicate CoI being involved in the generation of a Co hydride, which subsequently adds to alkenes initiating the isomerization. Alkenes 146-153 mitochondrially encoded cytochrome c oxidase I Homo sapiens 65-68 30889359-2 2019 In this manuscript, density functional theory calculations were performed to investigate the mechanism and origin of stereoselectivity of Pd-catalyzed cascade annulation of aryl iodide, alkene, and carbon monoxide to access the core of cephanolides B and C. It was found that the favorable mechanism proceeds via oxidative addition of Ar-I bond, migratory insertion of the C C bond, CO insertion into the Pd-(sp3) bond, Ar-H activation, and C(sp2)-C(sp2) reductive elimination. Alkenes 186-192 ariadne RBR E3 ubiquitin protein ligase 1 Homo sapiens 335-339 30889359-2 2019 In this manuscript, density functional theory calculations were performed to investigate the mechanism and origin of stereoselectivity of Pd-catalyzed cascade annulation of aryl iodide, alkene, and carbon monoxide to access the core of cephanolides B and C. It was found that the favorable mechanism proceeds via oxidative addition of Ar-I bond, migratory insertion of the C C bond, CO insertion into the Pd-(sp3) bond, Ar-H activation, and C(sp2)-C(sp2) reductive elimination. Alkenes 186-192 low density lipoprotein receptor adaptor protein 1 Homo sapiens 420-424 30889359-2 2019 In this manuscript, density functional theory calculations were performed to investigate the mechanism and origin of stereoselectivity of Pd-catalyzed cascade annulation of aryl iodide, alkene, and carbon monoxide to access the core of cephanolides B and C. It was found that the favorable mechanism proceeds via oxidative addition of Ar-I bond, migratory insertion of the C C bond, CO insertion into the Pd-(sp3) bond, Ar-H activation, and C(sp2)-C(sp2) reductive elimination. Alkenes 186-192 Sp2 transcription factor Homo sapiens 441-446 30889359-2 2019 In this manuscript, density functional theory calculations were performed to investigate the mechanism and origin of stereoselectivity of Pd-catalyzed cascade annulation of aryl iodide, alkene, and carbon monoxide to access the core of cephanolides B and C. It was found that the favorable mechanism proceeds via oxidative addition of Ar-I bond, migratory insertion of the C C bond, CO insertion into the Pd-(sp3) bond, Ar-H activation, and C(sp2)-C(sp2) reductive elimination. Alkenes 186-192 Sp2 transcription factor Homo sapiens 448-453 30789171-2 2019 In 2015, the Li group reported a BCl3 mediated aminoboration of unfunctionalized olefins. Alkenes 81-88 BCL3 transcription coactivator Homo sapiens 33-37 30789744-2 2019 In(OTf)3-catalyzed [4 + 2] cyclization of the sulfonylamidocyclobutanes with another molecule of DMM or other electron-deficient alkenes was also reported. Alkenes 129-136 POU class 5 homeobox 1 Homo sapiens 3-8 30600873-3 2019 Using directed evolution, we have engineered a hemoprotein biocatalyst based on a thermostable cytochrome c that directly transforms alkenes to amino alcohols with high enantioselectivity (up to 2500 TTN and 90 % ee) under anaerobic conditions with O-pivaloylhydroxylamine as an aminating reagent. Alkenes 133-140 cytochrome c, somatic Homo sapiens 95-107 30600873-3 2019 Using directed evolution, we have engineered a hemoprotein biocatalyst based on a thermostable cytochrome c that directly transforms alkenes to amino alcohols with high enantioselectivity (up to 2500 TTN and 90 % ee) under anaerobic conditions with O-pivaloylhydroxylamine as an aminating reagent. Alkenes 133-140 titin Homo sapiens 200-203 30691130-4 2019 The X-ray structures of the adducts of RNase A and HEWL with [Pt(I)(Me)(dmphen)(olefin)] are not of very high quality, but overall data indicate that, upon reaction with RNase A, the compound coordinates the side chain of His105 upon releasing the iodide ligand, but retains the pentacoordination. Alkenes 80-86 ribonuclease pancreatic Bos taurus 39-46 30714383-3 2019 Additionally, nondirected C-H bond functionalization at the C-4" position with alkenes rendered complete C-H functionalization of five C-H bonds that formed a stable hexasubstituted benzene ring. Alkenes 79-86 complement C4A (Rodgers blood group) Homo sapiens 60-63 30512211-1 2019 Alkenes can be cleaved by means of the (3+2) cycloaddition and subsequent cycloreversion of 1,3-dipoles, classically ozone (O3 ), but the azide (R-N3 ) variant is rare. Alkenes 0-7 drosha ribonuclease III Homo sapiens 145-149 30315713-3 2019 An array of cyclobutanes with high selectivity has been achieved from commercially available aldehydes, ketones (or phosphorus ylide), and olefins with visible-light irradiation of a catalytic amount of (fac-tris(2-phenylpyridinato-C2 ,N)iridium) ([Ir(ppy)3 ]) at room temperature. Alkenes 139-146 FA complementation group C Homo sapiens 204-207 30600680-3 2019 Also, the more electron-rich cobalt center of the Co(-I) catalyst was found to contribute higher reactivity for alkene hydrogenation. Alkenes 112-118 mitochondrially encoded cytochrome c oxidase I Homo sapiens 50-55 30334594-6 2019 This operative pathway involves 1) rapid and reversible syn-migratory 1,2-insertion of the alkene into the Fe-Namido sigma bond at the monomer {N^N}FeII amido compound; 2) turnover-limiting Fe-C sigma bond aminolysis at the thus generated transient {N^N}FeII alkyl intermediate and 3) regeneration of the catalytically competent {N^N}FeII amido complex, which favours its dimer, likely representing the catalyst resting state, through rapid cycloamine displacement by substrate. Alkenes 91-97 synemin Homo sapiens 56-59 30828001-3 2019 Following our previous studies regarding the synthesis of (+)-spectaline, herein we report the first convergent synthesis of (-)-iso-6-spectaline using a cross-metathesis under thermal conditions where the cis-2,6-disubstituted piperidin-3-ol scaffold is condensed with a long alkyl chain containing a terminal olefin. Alkenes 311-317 suppressor of cytokine signaling 2 Homo sapiens 206-211 30392374-3 2018 Herein, an efficient and practical cooperative palladium/Lewis acid-catalyzed transfer hydrocyanation of alkenes and alkynes is presented using 1-methylcyclohexa-2,5-diene-1-carbonitrile as a benign and readily available HCN source. Alkenes 105-112 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 221-224 30591827-1 2018 The degenerative transfer of xanthates to olefins is enabled by the iridium-based photocatalyst [Ir{dF(CF3)ppy}2(dtbbpy)](PF6) under blue LED light irradiation. Alkenes 42-49 sperm associated antigen 17 Homo sapiens 122-125 30274116-5 2018 The nanobiocomposites was characterized using H-NMR and FTIR analysis it was found that secondary alkyl, allylic carbon, monosubstituted alkenes and sp2 hybridized CH bonds of alkenes were involved in binding of cerium and selenium nanoparticles with l-asparaginase for the formation of cerium selenium nanobiocomposite. Alkenes 137-144 asparaginase and isoaspartyl peptidase 1 Homo sapiens 251-265 30274116-5 2018 The nanobiocomposites was characterized using H-NMR and FTIR analysis it was found that secondary alkyl, allylic carbon, monosubstituted alkenes and sp2 hybridized CH bonds of alkenes were involved in binding of cerium and selenium nanoparticles with l-asparaginase for the formation of cerium selenium nanobiocomposite. Alkenes 176-183 asparaginase and isoaspartyl peptidase 1 Homo sapiens 251-265 30546477-1 2018 Highly active olefin metathesis catalysts were prepared by thermal spreading MoO3 and/or MoO2(acac)2 on MWW zeolites (MCM-22, delaminated MCM-56) and on two-dimensional MFI (all in NH4 + form). Alkenes 14-20 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Homo sapiens 118-121 30546477-1 2018 Highly active olefin metathesis catalysts were prepared by thermal spreading MoO3 and/or MoO2(acac)2 on MWW zeolites (MCM-22, delaminated MCM-56) and on two-dimensional MFI (all in NH4 + form). Alkenes 14-20 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Homo sapiens 138-141 30215066-1 2018 Reported herein is a novel iron-catalyzed, DTBP-mediated carboazidation of alkenes using cycloalkanes, CH2Cl2, CHCl3 and CCl4 as alkylating reagents to generate electrophilic or nucleophilic alkyl radicals. Alkenes 75-82 C-C motif chemokine ligand 4 Homo sapiens 121-125 30283948-1 2018 Ozonolysis of TMS-substituted olefins produces alpha-carbonyl TMS peroxides without cleavage of the C[double bond, length as m-dash]C bond. Alkenes 30-37 PYD and CARD domain containing Homo sapiens 14-17 30283948-1 2018 Ozonolysis of TMS-substituted olefins produces alpha-carbonyl TMS peroxides without cleavage of the C[double bond, length as m-dash]C bond. Alkenes 30-37 PYD and CARD domain containing Homo sapiens 62-65 30351937-0 2018 Cobalt-Catalyzed Secondary Alkylation of Arenes and Olefins with Alkyl Ethers through the Cleavage of C(sp2)-H and C(sp3)-O Bonds. Alkenes 52-59 Sp2 transcription factor Homo sapiens 102-107 30339397-2 2018 The hydroboration of alkenes in the presence of HBpin, PPh3, and NaO tBu affords good to excellent yields with high Markovnikov selectivity with up to 97:3 branched/linear selectivity. Alkenes 21-28 protein phosphatase 4 catalytic subunit Homo sapiens 55-59 30382103-4 2018 This catalytic protocol, synergistically combining Ir/Ni-catalyzed alkyne difunctionalization with photoinduced alkene isomerization, affords trisubstituted alkenes with excellent efficiency and syn-stereoselectivity. Alkenes 112-118 synemin Homo sapiens 25-28 30192145-3 2018 Herein, we have developed a highly efficient Rh(II)-catalyzed method for the direct preparation of unactivated aziridines from olefins using O-(sulfonyl)hydroxylamines as the aminating agent. Alkenes 127-134 Rh blood group D antigen Homo sapiens 45-50 30300955-2 2018 The present approach relies on an asymmetric olefin cyclopropanation reaction catalyzed by an engineered myoglobin in the presence of ex situ generated diazoacetonitrile within a compartmentalized reaction system. Alkenes 45-51 myoglobin Homo sapiens 105-114 30345997-1 2018 An efficient four-component radical cascade reaction of alkenes, enabled by an EDA complex between Togni"s reagent and Hantzsch ester, has been reported. Alkenes 56-63 ectodysplasin A Homo sapiens 79-82 30385749-3 2018 Taf14-YEATS selects for crotonyllysine, forming pi stacking with both the crotonyl amide and the alkene moiety, whereas AF9-YEATS exhibits comparable affinities to saturated and unsaturated acyllysines, engaging them through pi stacking with the acyl amide. Alkenes 97-103 TATA-binding protein-associated factor TAF14 Saccharomyces cerevisiae S288C 0-5 30221278-1 2018 The direct, catalytic vicinal difluorination of terminal alkenes via an I(i)/I(iii) manifold was exploited to install a chiral, hybrid bioisostere of the CF3 and Et groups (BITE) in Gilenya ; the first orally available drug for the clinical management of Multiple Sclerosis (MS). Alkenes 57-64 centrosomal protein 70 Homo sapiens 173-177 30118203-1 2018 In the nearly 80 years since catalytic hydroformylation was first reported, hundreds of billions of pounds of aldehyde have been produced by this atom efficient one-carbon homologation of alkenes in the presence of H2 and CO. Alkenes 188-195 relaxin 2 Homo sapiens 215-224 30153002-4 2018 Demonstration of catalytic alkene prefunctionalization, via spectroscopic observation of an organocobalt species, distinguishes this Csp2-Csp3 cross-coupling method from a conventional transmetalation process, which employs a stoichiometric organometallic nucleophile, and from a bimetallic oxidative addition of an organohalide across nickel, described by radical scission and subsequent alkyl radical capture at a second nickel center. Alkenes 27-33 regulator of calcineurin 2 Homo sapiens 133-137 30052045-0 2018 Proximal Pocket Controls Alkene Oxidation Selectivity of Cytochrome P450 and Chloroperoxidase toward Small, Nonpolar Substrates. Alkenes 25-31 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 57-93 30124291-0 2018 Mechanistic Exploration of Cp*CoIII/RhIII-Catalyzed Carboamination/Olefination of N-Phenoxyacetamides with Alkenes. Alkenes 107-114 mitochondrially encoded cytochrome c oxidase III Homo sapiens 30-35 30124291-1 2018 A computational study of Cp*CoIII/RhIII-catalyzed carboamination/olefination of N-phenoxyacetamides with alkenes was carried out to elucidate the catalyst-controlled chemoselectivity. Alkenes 105-112 mitochondrially encoded cytochrome c oxidase III Homo sapiens 28-33 30258135-7 2018 This olefin-hydroaminoalkylation process involves a visible-light-mediated reduction of in-situ-generated iminium ions to selectively furnish previously inaccessible alkyl-substituted alpha-amino radicals, which subsequently react with alkenes to form C(sp3)-C(sp3) bonds. Alkenes 5-11 Sp3 transcription factor Homo sapiens 254-257 30258135-7 2018 This olefin-hydroaminoalkylation process involves a visible-light-mediated reduction of in-situ-generated iminium ions to selectively furnish previously inaccessible alkyl-substituted alpha-amino radicals, which subsequently react with alkenes to form C(sp3)-C(sp3) bonds. Alkenes 5-11 Sp3 transcription factor Homo sapiens 261-264 30258135-7 2018 This olefin-hydroaminoalkylation process involves a visible-light-mediated reduction of in-situ-generated iminium ions to selectively furnish previously inaccessible alkyl-substituted alpha-amino radicals, which subsequently react with alkenes to form C(sp3)-C(sp3) bonds. Alkenes 236-243 Sp3 transcription factor Homo sapiens 254-257 30258135-7 2018 This olefin-hydroaminoalkylation process involves a visible-light-mediated reduction of in-situ-generated iminium ions to selectively furnish previously inaccessible alkyl-substituted alpha-amino radicals, which subsequently react with alkenes to form C(sp3)-C(sp3) bonds. Alkenes 236-243 Sp3 transcription factor Homo sapiens 261-264 30011194-6 2018 Most of these transformations involve the photochemical induced generation of a radical followed by its regioselective addition to arenes, heteroarenes, or alkenes, leading to the building of a new C(sp2)-C bond. Alkenes 156-163 Sp2 transcription factor Homo sapiens 198-203 29916255-1 2018 We herein present a flexible approach for the incorporation of CF3 units into a predefined site of electron-rich alkenes that exploits the regiocontrolled introduction of an iodine handle and subsequent trifluoromethylation of the C(sp2)-I bond using fluoroform-derived "ligandless" CuCF3. Alkenes 113-120 Sp2 transcription factor Homo sapiens 231-236 30027965-1 2018 A mild and general visible light photoredox catalysis-induced intermolecular three-component alkene 1,2-diarylation involving aryl C(sp2)-H functionalization is described. Alkenes 93-99 Sp2 transcription factor Homo sapiens 131-136 30027965-2 2018 The key to controlling the chemoselectivity toward alkene 1,2-diarylation is the employment of a 2,2"-bipyridine base, thus allowing the formation of two new C(sp3)-C(sp2) bonds via aryl radical formation from aryldiazonium salts, addition across the C[double bond, length as m-dash]C bonds, and aryl C(sp2)-H functionalization cascades. Alkenes 51-57 Sp2 transcription factor Homo sapiens 165-170 30027965-2 2018 The key to controlling the chemoselectivity toward alkene 1,2-diarylation is the employment of a 2,2"-bipyridine base, thus allowing the formation of two new C(sp3)-C(sp2) bonds via aryl radical formation from aryldiazonium salts, addition across the C[double bond, length as m-dash]C bonds, and aryl C(sp2)-H functionalization cascades. Alkenes 51-57 Sp2 transcription factor Homo sapiens 301-306 29979868-8 2018 Catalyst K-1 is reusable and can be applied to the hydroformylation of linear olefins, styrene, 4-vinylcyclohexene, and dienes, as well as representative terpenes and other unsaturated hydrocarbons in a batch reactor. Alkenes 78-85 keratin 1 Homo sapiens 9-12 29792688-3 2018 The X-type PAlP-Rh complexes catalyze C2-selective monoalkylation of pyridine with alkenes. Alkenes 83-90 alkaline phosphatase, placental Homo sapiens 11-15 29903660-1 2018 Novel acetyl-CoA carboxylase 2 (ACC2) selective inhibitors were identified by the conversion of the alkyne unit of A-908292 to the olefin linker. Alkenes 131-137 acetyl-Coenzyme A carboxylase beta Mus musculus 32-36 29708344-4 2018 Subsequent efforts are presented to introduce the C1,C2 cis-diamino moiety en route to pactamycin, including carbamate-mediated alkene aziridination. Alkenes 128-134 heterogeneous nuclear ribonucleoprotein C Homo sapiens 50-55 29873126-1 2018 Solar-driven Fischer-Tropsch synthesis represents an alternative and potentially low-cost route for the direct production of light olefins from syngas (CO and H2 ). Alkenes 131-138 relaxin 2 Homo sapiens 152-161 29808214-3 2018 Instead of the general mechanism of rhodium-catalyzed VCP-alkyne cycloaddition that involves cyclopropane cleavage, alkyne insertion and reductive elimination, the rhodium-catalyzed VOR-alkyne cycloaddition occurs via oxidative alkyne-alkene cyclization, oxirane cleavage and reductive elimination. Alkenes 235-241 valosin containing protein Homo sapiens 54-57 29671568-2 2018 Recently, a ZJNU-30 metal-organic framework (MOF) has been found to have the potential for adsorption-based separation of olefins and diolefins with four carbon atoms [H. M. Liu et al. Alkenes 122-129 lysine acetyltransferase 8 Homo sapiens 12-49 29781006-0 2018 Pd-Catalyzed reductive heck reaction of olefins with aryl bromides for Csp2-Csp3 bond formation. Alkenes 40-47 regulator of calcineurin 2 Homo sapiens 71-75 29781006-1 2018 We developed a Pd-catalyzed intermolecular reductive Heck reaction to construct Csp2-Csp3 bonds between aryl bromides and olefins. Alkenes 122-129 regulator of calcineurin 2 Homo sapiens 80-84 29648809-0 2018 Iron(MCP) Complexes Catalyze Aziridination with Olefins As Limiting Reagents. Alkenes 48-55 CD46 molecule Homo sapiens 5-8 29693092-3 2018 In direct agreement with empirical trends, alkene insertion into Ni-C bonds on COM1 is exclusively favoured over the competing alkyne insertion. Alkenes 43-49 nuclear protein 1, transcriptional regulator Homo sapiens 79-83 29694036-4 2018 A copper-catalyzed fluorotrifluoromethylation of unactivated alkenes was then successfully developed with CsF as the fluorine source and Umemoto"s reagent as the trifluoromethylating agent. Alkenes 61-68 colony stimulating factor 2 Homo sapiens 106-109 29417107-5 2018 Indeed, the fast HO2 formation timescale is nearly temperature independent both for cyclohexyl + O2 and for tetrahydropyranyl + O2 below 700 K. A slower HO2 formation timescale in cyclohexane oxidation is shown to be linked to the sequential R + O2 ROO alkene + HO2 pathway, and displays a strong temperature dependence mainly from the final step (with energy barrier ~32.5 kcal mol-1). Alkenes 261-267 heme oxygenase 2 Homo sapiens 17-20 31458676-9 2018 Reactions of the single cycloiridated complex 3b with terminal aromatic alkynes result in the corresponding five- and six-membered doubly cycloiridated complex 12 and/or eta2-alkene coordinated complexes 13-15; the latter discloses that the electronic effect of terminal alkynes affects the regioselectivity. Alkenes 175-181 DNA polymerase iota Homo sapiens 170-174 29417107-5 2018 Indeed, the fast HO2 formation timescale is nearly temperature independent both for cyclohexyl + O2 and for tetrahydropyranyl + O2 below 700 K. A slower HO2 formation timescale in cyclohexane oxidation is shown to be linked to the sequential R + O2 ROO alkene + HO2 pathway, and displays a strong temperature dependence mainly from the final step (with energy barrier ~32.5 kcal mol-1). Alkenes 261-267 heme oxygenase 2 Homo sapiens 154-157 29417107-5 2018 Indeed, the fast HO2 formation timescale is nearly temperature independent both for cyclohexyl + O2 and for tetrahydropyranyl + O2 below 700 K. A slower HO2 formation timescale in cyclohexane oxidation is shown to be linked to the sequential R + O2 ROO alkene + HO2 pathway, and displays a strong temperature dependence mainly from the final step (with energy barrier ~32.5 kcal mol-1). Alkenes 261-267 heme oxygenase 2 Homo sapiens 154-157 29577133-1 2018 An efficient strategy for the synthesis of C-2 and C-3 branched sugar dienes via cross dehydrogenative coupling of sugar enol ethers with terminal alkenes was developed. Alkenes 147-154 complement C2 Homo sapiens 43-46 29577133-1 2018 An efficient strategy for the synthesis of C-2 and C-3 branched sugar dienes via cross dehydrogenative coupling of sugar enol ethers with terminal alkenes was developed. Alkenes 147-154 complement C3 Homo sapiens 51-54 29451952-6 2018 Isoreticular expansion of microporous shells and orthogonal modification of the core was realized to produce multifunctional MOF composites, which acted as size selective catalysts for olefin epoxidation with high activity and selectivity. Alkenes 185-191 lysine acetyltransferase 8 Homo sapiens 125-128 29552884-2 2018 Different from the previous HAT-type olefin cross-coupling reactions, the presence of a fluorine atom in the molecule results in a stereoselective beta-F cleavage, leading to a C(sp2)-C(sp3) bond formation. Alkenes 37-43 Sp2 transcription factor Homo sapiens 177-182 29583000-0 2018 Chiral Selenide-Catalyzed Enantioselective Allylic Reaction and Intermolecular Difunctionalization of Alkenes: Efficient Construction of C-SCF3 Stereogenic Molecules. Alkenes 102-109 mitogen-activated protein kinase kinase kinase 7 Homo sapiens 137-142 29536213-0 2018 Reaction mechanism of organoselenium-catalyzed syn-dichlorination of alkenes: a DFT study. Alkenes 69-76 synemin Homo sapiens 47-50 29441778-3 2018 The catalytic system is tolerant to a variety of functional groups including nitrile, allylic ether, and alkene and could be extended to the synthesis of bis-amide, antiemetic drug Tigan, and dopamine D2 receptor antagonist Itopride. Alkenes 105-111 dopamine receptor D2 Homo sapiens 192-212 29536213-1 2018 A new method for the syn-dichlorination of alkenes at room temperature has been proposed by Denmark et al. Alkenes 43-50 synemin Homo sapiens 21-24 29160705-1 2017 Using theoretical calculations and Born-Oppenheimer molecular dynamics simulations, it is shown here that Criegee intermediate, which is principally produced in the olefin ozonolysis, can activate H-X (X = H, CH3, CH2F, CHF2, CF3, and SiH3) under mild conditions, a reaction that has long been known for transition metals. Alkenes 165-171 hes related family bHLH transcription factor with YRPW motif 1 Homo sapiens 220-224 29431443-1 2018 The vinyl hydroperoxide (VHP), the major isomerization product of the syn-alkyl Criegee intermediate (CI) formed in alkene ozonolysis, is a direct precursor of hydroxyl radical (OH), the most important oxidant in the troposphere. Alkenes 116-122 synemin Homo sapiens 70-73 29465996-7 2018 Deuterium labeling experiments support a mechanism involving syn-addition across the alkene. Alkenes 85-91 synemin Homo sapiens 61-64 29520021-0 2018 Cation vacancy stabilization of single-atomic-site Pt1/Ni(OH)x catalyst for diboration of alkynes and alkenes. Alkenes 102-109 zinc finger protein 77 Homo sapiens 51-54 29520021-5 2018 This Pt1/Ni(OH)x catalyst shows a high catalytic efficiency in diboration of a variety of alkynes and alkenes, yielding an overall turnover frequency value upon reaction completion for phenylacetylene of ~3000 h-1, which is much higher than other reported heterogeneous catalysts. Alkenes 102-109 zinc finger protein 77 Homo sapiens 5-8 29355868-6 2018 For primary and secondary substrates, the first transition structure is a 6-center syn-rearrangement of the alkanesulfonyl chloride that produces the corresponding olefin by simultaneous expulsion of HCl and SO2. Alkenes 164-170 synemin Homo sapiens 83-86 29355868-8 2018 The final syn-addition of HCl to the olefin leads to alkyl chloride with the retention of configuration. Alkenes 37-43 synemin Homo sapiens 10-13 29219322-1 2018 Hydrosilylation of various sulfur-containing olefins with (RO)3SiH has been achieved using iridium catalysts [IrX(cod)]2 (X = Cl, SPh). Alkenes 45-52 surfactant associated 3 Homo sapiens 130-133 29182327-6 2017 Density functional theory calculations further disclosed that, in the presence of Sc(OTf)3, the Sc3+ adducts of FeIII-OOH and FeIV O species are capable of epoxidizing olefin as well as FeV O species, thus opening multiple channels for oxygenation. Alkenes 168-174 POU class 5 homeobox 1 Homo sapiens 82-90 29069541-4 2017 Unsaturated compounds, such as alkenes, aromatics, and carbonyls, exhibit a different correlation for allylic and benzylic C-H bonds (DeltaH unsat = 0.35*BDE - 13.1). Alkenes 31-38 homeobox D13 Homo sapiens 154-157 29675177-2 2018 Here we report a quinoline-derived ligand that enables the Pd(ii)-catalyzed olefination of the C(sp2)-H bond with simple aliphatic alkenes using a weakly coordinating monodentate amide auxiliary. Alkenes 131-138 Sp2 transcription factor Homo sapiens 95-100 29104971-0 2017 Palladium catalyzed direct aliphatic gammaC(sp3)-H alkenylation with alkenes and alkenyl iodides. Alkenes 69-76 Sp3 transcription factor Homo sapiens 44-47 29068683-4 2017 In pathway B, two basic routes (B1 and B2) are possible, which can take place through different reaction steps, including the extrusion of alkene from Re(V)-diolate in route B1, and the second reduction of the Re(V)-diolate by reductant and then the extrusion of alkene from the Re(III)-diolate intermediate in route B2. Alkenes 139-145 immunoglobulin kappa variable 7-3 (pseudogene) Homo sapiens 32-41 28640940-2 2017 Transition-metal complexes facilitate the C-H activation of indoles or alkenes allowing an efficient Csp2 - Csp2 bond formation. Alkenes 71-78 regulator of calcineurin 2 Homo sapiens 101-105 28640940-2 2017 Transition-metal complexes facilitate the C-H activation of indoles or alkenes allowing an efficient Csp2 - Csp2 bond formation. Alkenes 71-78 regulator of calcineurin 2 Homo sapiens 108-112 29068683-4 2017 In pathway B, two basic routes (B1 and B2) are possible, which can take place through different reaction steps, including the extrusion of alkene from Re(V)-diolate in route B1, and the second reduction of the Re(V)-diolate by reductant and then the extrusion of alkene from the Re(III)-diolate intermediate in route B2. Alkenes 263-269 immunoglobulin kappa variable 7-3 (pseudogene) Homo sapiens 32-41 28901363-1 2017 Density functional theory (DFT, B3LYP-D3 with implicit solvation in toluene) was used to investigate the mechanisms of olefin hydrosilylation catalyzed by PDI(Fe) (bis(imino)pyridine iron) complexes, where PDI = 2,6-(ArN[double bond, length as m-dash]CMe)2(C5H3N) with Ar = 2,6-R2-C6H3. Alkenes 119-125 peptidyl arginine deiminase 1 Homo sapiens 155-158 28952315-2 2017 Under the catalysis from a Rh(II) complex, this class of alpha-diazo imidates reacted with alkenes and conjugated dienes through a formal [2 + 1] (i.e., cyclopropanation) or [4 + 3] cycloaddition to furnish spiro[cyclopropane-1,4"-isochroman]-3"-imines and tetrahydroisochromeno[3,4-b] azepines, respectively. Alkenes 91-98 Rh blood group D antigen Homo sapiens 27-33 28901363-4 2017 (PDI)Fe(alkyl)(SiEt3) then undergoes C-Si reductive elimination to form (PDI)Fe, which coordinates an olefin ligand to regenerate the resting state (PDI)Fe(olefin). Alkenes 102-108 peptidyl arginine deiminase 1 Homo sapiens 1-4 28901363-4 2017 (PDI)Fe(alkyl)(SiEt3) then undergoes C-Si reductive elimination to form (PDI)Fe, which coordinates an olefin ligand to regenerate the resting state (PDI)Fe(olefin). Alkenes 102-108 peptidyl arginine deiminase 1 Homo sapiens 73-76 28901363-1 2017 Density functional theory (DFT, B3LYP-D3 with implicit solvation in toluene) was used to investigate the mechanisms of olefin hydrosilylation catalyzed by PDI(Fe) (bis(imino)pyridine iron) complexes, where PDI = 2,6-(ArN[double bond, length as m-dash]CMe)2(C5H3N) with Ar = 2,6-R2-C6H3. Alkenes 119-125 peptidyl arginine deiminase 1 Homo sapiens 206-209 28901363-4 2017 (PDI)Fe(alkyl)(SiEt3) then undergoes C-Si reductive elimination to form (PDI)Fe, which coordinates an olefin ligand to regenerate the resting state (PDI)Fe(olefin). Alkenes 102-108 peptidyl arginine deiminase 1 Homo sapiens 73-76 28901363-4 2017 (PDI)Fe(alkyl)(SiEt3) then undergoes C-Si reductive elimination to form (PDI)Fe, which coordinates an olefin ligand to regenerate the resting state (PDI)Fe(olefin). Alkenes 156-162 peptidyl arginine deiminase 1 Homo sapiens 1-4 28901363-2 2017 We find that the rate-determining step for hydrosilylation is hydride migration from Et3SiH onto the Fe-bound olefin to form (PDI)Fe(alkyl)(SiEt3). Alkenes 110-116 peptidyl arginine deiminase 1 Homo sapiens 126-129 28901363-4 2017 (PDI)Fe(alkyl)(SiEt3) then undergoes C-Si reductive elimination to form (PDI)Fe, which coordinates an olefin ligand to regenerate the resting state (PDI)Fe(olefin). Alkenes 156-162 peptidyl arginine deiminase 1 Homo sapiens 73-76 28989623-2 2017 ENDOR spectroscopy led to the conclusion that these intermediates have eta2 binding of the alkene, with the hydrogens on the terminal carbon structurally/magnetically equivalent and related by local mirror symmetry. Alkenes 91-97 DNA polymerase iota Homo sapiens 71-75 28901363-4 2017 (PDI)Fe(alkyl)(SiEt3) then undergoes C-Si reductive elimination to form (PDI)Fe, which coordinates an olefin ligand to regenerate the resting state (PDI)Fe(olefin). Alkenes 156-162 peptidyl arginine deiminase 1 Homo sapiens 73-76 28820252-0 2017 Computational Study on M1/POM Single-Atom Catalysts (M = Cu, Zn, Ag, and Au; POM = [PW12O40]3-): Metal-Support Interactions and Catalytic Cycle for Alkene Epoxidation. Alkenes 148-154 myoregulin Homo sapiens 23-29 28745445-2 2017 The diastereomeric chiral CoIII -templated Bronsted acids, with the same chiral ligands, enabled a switch in the enantioselective bromoaminocyclization of olefins to afford the two enantiomers of 2-substituted pyrrolidines with high enantioselectivities (up to 99:1 e.r. Alkenes 155-162 mitochondrially encoded cytochrome c oxidase III Homo sapiens 26-31 28767230-0 2017 Mechanistically Driven Development of an Iron Catalyst for Selective Syn-Dihydroxylation of Alkenes with Aqueous Hydrogen Peroxide. Alkenes 92-99 synemin Homo sapiens 69-72 28767230-1 2017 Product release is the rate-determining step in the arene syn-dihydroxylation reaction taking place at Rieske oxygenase enzymes and is regarded as a difficult problem to be resolved in the design of iron catalysts for olefin syn-dihydroxylation with potential utility in organic synthesis. Alkenes 218-224 synemin Homo sapiens 58-61 28767230-1 2017 Product release is the rate-determining step in the arene syn-dihydroxylation reaction taking place at Rieske oxygenase enzymes and is regarded as a difficult problem to be resolved in the design of iron catalysts for olefin syn-dihydroxylation with potential utility in organic synthesis. Alkenes 218-224 synemin Homo sapiens 225-228 28989623-4 2017 Here, we report an ENDOR study of the crystallographically characterized biomimetic iron(i) complex 1, which exhibits eta2 coordination of styrene, thus connecting hyperfine and structural parameters of an Fe-bound alkene fragment for the first time. Alkenes 215-221 DNA polymerase iota Homo sapiens 118-122 28604897-1 2017 The reactions of Criegee intermediates with NO2 have been proposed as a potentially significant source of the important nighttime oxidant NO3, particularly in urban environments where concentrations of ozone, alkenes and NOx are high. Alkenes 209-216 NBL1, DAN family BMP antagonist Homo sapiens 138-141 28472549-3 2017 "Chain doubling" by a subsequent catalytic olefin metathesis step, which overcomes the low reactivity of this substrates by using waste internal olefins as recyclable co-reagents, yields ultra-long-chain alpha,omega-difunctional building blocks of a precise chain length, as demonstrated up to a C48 chain. Alkenes 43-49 CDK5 regulatory subunit associated protein 2 Homo sapiens 296-299 28737904-1 2017 We disclose a strategy for Ni-catalyzed dicarbofunctionalization of olefins in styrenes by intercepting Heck C(sp3)-NiX intermediates with arylzinc reagents. Alkenes 68-75 BCL2 interacting protein 3 like Homo sapiens 116-119 28671845-3 2017 A recent report from our group showed that silica-supported Co(II) sites, prepared via surface organometallic chemistry, are active in both alkene hydrogenation and alkane dehydrogenation, possibly linked to the Lewis acidity of the Co(II) sites. Alkenes 140-146 mitochondrially encoded cytochrome c oxidase II Homo sapiens 60-66 28671845-3 2017 A recent report from our group showed that silica-supported Co(II) sites, prepared via surface organometallic chemistry, are active in both alkene hydrogenation and alkane dehydrogenation, possibly linked to the Lewis acidity of the Co(II) sites. Alkenes 140-146 mitochondrially encoded cytochrome c oxidase II Homo sapiens 233-239 28756661-4 2017 Using a combination of experiment and theory, we show that nanoalloying Pt7 with boron modifies the alkene-binding affinity to reduce coking. Alkenes 100-106 zinc finger protein 79 Homo sapiens 72-75 28614619-1 2017 A RhII -catalyzed direct and stereospecific N-H- and N-alkyl aziridination of olefins is reported that uses hydroxylamine-O-sulfonic acids as inexpensive, readily available, and nitro group-free aminating reagents. Alkenes 78-85 Rh blood group D antigen Homo sapiens 2-6 28472549-3 2017 "Chain doubling" by a subsequent catalytic olefin metathesis step, which overcomes the low reactivity of this substrates by using waste internal olefins as recyclable co-reagents, yields ultra-long-chain alpha,omega-difunctional building blocks of a precise chain length, as demonstrated up to a C48 chain. Alkenes 145-152 CDK5 regulatory subunit associated protein 2 Homo sapiens 296-299 27687857-2 2017 Compound 1 has a alpha,beta-unsaturated-gamma-lactone ring conjugated with the C-22/23 olefin in the C-17 side chain. Alkenes 87-93 cytokine like 1 Homo sapiens 101-105 28521105-1 2017 A sequential construction of C-C, C-O, C N, and C O bonds from alkenes leading to the direct synthesis of isoxazolines in the presence of tert-butyl nitrite, quinoline, and the Sc(OTf)3 catalyst in DCE at 80 C has been accomplished. Alkenes 63-70 POU class 5 homeobox 1 Homo sapiens 177-185 33429562-3 2017 Macromonomer is polymerized via olefin metathesis living cyclopolymerization method using the Grubbs-Hoveyda catalyst to produce a water-soluble Dox-Peg-Rcp-Fmoc polymer. Alkenes 32-38 CGRP receptor component Homo sapiens 153-156 28342136-1 2017 Cytochrome P450 OleTJE has attracted much attention for its ability to catalyze the decarboxylation of long chain fatty acids to generate alkenes, which are not only biofuel molecule, but also can be used broadly for making lubricants, polymers and detergents. Alkenes 138-145 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 11-15 28534837-3 2017 Several highly selective transformations of alkenes such as allylic or vinylic imidation, pyridination, syn-dichlorination, oxidative cyclization and asymmetric cyclization have been described. Alkenes 44-51 synemin Homo sapiens 104-107 27936967-4 2017 Areas covered: The authors focus on MPO-mediated metabolism of alkene hydrocarbons to form chlorohydrins and the potential role of chlorohydrins in alkene toxicity and carcinogenicity. Alkenes 63-69 myeloperoxidase Homo sapiens 36-39 28353346-0 2017 Csp-Csp3 Bond Formation via Iron(III)-Promoted Hydroalkynylation of Unactivated Alkenes. Alkenes 80-87 DnaJ heat shock protein family (Hsp40) member C5 Homo sapiens 0-3 28254699-4 2017 The alkene bridge of CA-4 is replaced with a beta-lactam ring to circumvent potential isomerisation while the potential sites of glucuronate conjugation are deleted in the novel 3-substituted-1,4-diaryl-2-azetidinone analogues of CA-4. Alkenes 4-10 carbonic anhydrase 4 Homo sapiens 21-25 28353346-1 2017 An iron(III)-promoted hydroalkynylation of unactivated alkenes toward Csp-Csp3 bond formation has been developed. Alkenes 55-62 DnaJ heat shock protein family (Hsp40) member C5 Homo sapiens 70-73 28004185-3 2017 The enzymatic conversion of Cn chain length fatty aldehydes (or acids) to Cn-1 hydrocarbons, alkanes or alkenes, involves a C-C scission reaction. Alkenes 104-111 5'-nucleotidase, cytosolic IA Homo sapiens 74-78 28229599-2 2017 Notably, the configuration of these tetrasubstituted olefins was dominated by the trans-oxopalladation step where the aryl group derived from ArX is located trans to the oxygen attached in the double bond. Alkenes 53-60 aristaless related homeobox Homo sapiens 142-145 28124122-8 2017 Eventually, the work presents a state-of-the-art report on the use of these catalysts in aliphatic C-H oxidation, olefin epoxidation and alkene syn-dihydroxylation, under substrate-limiting conditions. Alkenes 137-143 synemin Homo sapiens 144-147 28217896-3 2017 Herein, we report the identification and characterization of a dimeric PdI species in two prototypical Pd-catalyzed aerobic oxidation reactions: allylic C-H acetoxylation of terminal alkenes and intramolecular aza-Wacker cyclization. Alkenes 183-190 prolyl 4-hydroxylase subunit beta Homo sapiens 71-74 28207262-3 2017 The obtained rate constants are in good agreement with experimental data for alkene epoxidation by HO2. Alkenes 77-83 heme oxygenase 2 Homo sapiens 99-102 28120972-2 2017 The use of a ( )-[Ru(SAr)2(CO)2]6 wheel for catalytic aziridination of alkenes via nitrene transfer is also described. Alkenes 71-78 CD82 molecule Homo sapiens 21-26 31457465-1 2017 Long-range olefin isomerization of 2-alkenylbenzoic acid derivatives going through two to five sp3-carbon atoms to give (E)-alkenes was achieved with palladium(0) nanoparticles. Alkenes 11-17 Sp3 transcription factor Homo sapiens 95-98 28111868-0 2017 Direct Syn Addition of Two Silicon Atoms to a C C Triple Bond by Si-Si Bond Activation: Access to Reactive Disilylated Olefins. Alkenes 119-126 synemin Homo sapiens 7-10 31961510-6 2017 The B12 -TiO2 hybrid catalyst was used for hydrogen evolution and alkene reduction by UV light irradiation, and the cobalt-hydrogen complex (Co-H complex) was considered to be a putative intermediate of the reactions. Alkenes 66-72 NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens 4-7 28088866-10 2017 In addition, at higher temperatures, another mechanism can contribute, in which hydrogen atoms abstract hydrogen from C12H26 producing various n-dodecyl radicals and these radicals then decompose by C-C bond beta-scission to C3 to C11 alkenes. Alkenes 235-242 aldo-keto reductase family 1 member C4 Homo sapiens 231-234 28051870-0 2017 Asymmetric Radical Cyclopropanation of Alkenes with In Situ-Generated Donor-Substituted Diazo Reagents via Co(II)-Based Metalloradical Catalysis. Alkenes 39-46 mitochondrially encoded cytochrome c oxidase II Homo sapiens 107-112 28051870-3 2017 This Co(II)-based metalloradical system represents the first catalytic protocol that can effectively utilize donor-type diazo reagents for asymmetric olefin cyclopropanation. Alkenes 150-156 mitochondrially encoded cytochrome c oxidase II Homo sapiens 5-10 27872191-1 2017 Glutathione S-transferase pi 1 (GSTP1) is frequently overexpressed in cancerous tumors and is a putative target of the plant compound piperlongumine (PL), which contains two reactive olefins and inhibits proliferation in cancer cells but not normal cells. Alkenes 183-190 glutathione S-transferase pi 1 Homo sapiens 0-30 27872191-1 2017 Glutathione S-transferase pi 1 (GSTP1) is frequently overexpressed in cancerous tumors and is a putative target of the plant compound piperlongumine (PL), which contains two reactive olefins and inhibits proliferation in cancer cells but not normal cells. Alkenes 183-190 glutathione S-transferase pi 1 Homo sapiens 32-37 27872191-1 2017 Glutathione S-transferase pi 1 (GSTP1) is frequently overexpressed in cancerous tumors and is a putative target of the plant compound piperlongumine (PL), which contains two reactive olefins and inhibits proliferation in cancer cells but not normal cells. Alkenes 183-190 galectin 1 Homo sapiens 150-152 27872191-3 2017 These data in tandem with other information led to the conclusion that PL inhibits GSTP1, which forms covalent bonds between GSH and various electrophilic compounds, through covalent adduct formation at the C7-C8 olefin of PL, whereas the C2-C3 olefin of PL was postulated to react with GSH. Alkenes 213-219 galectin 1 Homo sapiens 71-73 27872191-3 2017 These data in tandem with other information led to the conclusion that PL inhibits GSTP1, which forms covalent bonds between GSH and various electrophilic compounds, through covalent adduct formation at the C7-C8 olefin of PL, whereas the C2-C3 olefin of PL was postulated to react with GSH. Alkenes 213-219 glutathione S-transferase pi 1 Homo sapiens 83-88 27872191-3 2017 These data in tandem with other information led to the conclusion that PL inhibits GSTP1, which forms covalent bonds between GSH and various electrophilic compounds, through covalent adduct formation at the C7-C8 olefin of PL, whereas the C2-C3 olefin of PL was postulated to react with GSH. Alkenes 213-219 galectin 1 Homo sapiens 223-225 27872191-3 2017 These data in tandem with other information led to the conclusion that PL inhibits GSTP1, which forms covalent bonds between GSH and various electrophilic compounds, through covalent adduct formation at the C7-C8 olefin of PL, whereas the C2-C3 olefin of PL was postulated to react with GSH. Alkenes 213-219 galectin 1 Homo sapiens 223-225 27872191-3 2017 These data in tandem with other information led to the conclusion that PL inhibits GSTP1, which forms covalent bonds between GSH and various electrophilic compounds, through covalent adduct formation at the C7-C8 olefin of PL, whereas the C2-C3 olefin of PL was postulated to react with GSH. Alkenes 245-251 galectin 1 Homo sapiens 71-73 27872191-3 2017 These data in tandem with other information led to the conclusion that PL inhibits GSTP1, which forms covalent bonds between GSH and various electrophilic compounds, through covalent adduct formation at the C7-C8 olefin of PL, whereas the C2-C3 olefin of PL was postulated to react with GSH. Alkenes 245-251 glutathione S-transferase pi 1 Homo sapiens 83-88 27872191-6 2017 Surprisingly, the structure showed that a hydrolysis product of PL (hPL) was conjugated to glutathione at the C7-C8 olefin, and this complex was bound to the active site of GSTP1; no covalent bond formation between hPL and GSTP1 was observed. Alkenes 116-122 galectin 1 Homo sapiens 64-66 27872191-6 2017 Surprisingly, the structure showed that a hydrolysis product of PL (hPL) was conjugated to glutathione at the C7-C8 olefin, and this complex was bound to the active site of GSTP1; no covalent bond formation between hPL and GSTP1 was observed. Alkenes 116-122 galectin 1 Homo sapiens 68-71 27872191-6 2017 Surprisingly, the structure showed that a hydrolysis product of PL (hPL) was conjugated to glutathione at the C7-C8 olefin, and this complex was bound to the active site of GSTP1; no covalent bond formation between hPL and GSTP1 was observed. Alkenes 116-122 glutathione S-transferase pi 1 Homo sapiens 173-178 27872191-8 2017 Moreover, MS data also indicated that nucleophilic attack on PL at the C2-C3 olefin led to PL hydrolysis. Alkenes 77-83 galectin 1 Homo sapiens 61-63 27872191-8 2017 Moreover, MS data also indicated that nucleophilic attack on PL at the C2-C3 olefin led to PL hydrolysis. Alkenes 77-83 galectin 1 Homo sapiens 91-93 28156117-0 2017 Copper-Catalyzed B(dan)-Installing Carboboration of Alkenes. Alkenes 52-59 NBL1, DAN family BMP antagonist Homo sapiens 19-22 28156117-1 2017 Carboboration of alkenes was found to occur readily with an unsymmetrical diboron [(pin)B-B(dan)] and alkyl halides under copper catalysis, leading to the direct formation of protected alkylboron compounds via synchronous C-C and C-B bond-forming processes. Alkenes 17-24 NBL1, DAN family BMP antagonist Homo sapiens 92-95 28156117-2 2017 The B(dan) moiety was solely installed into the organic frameworks with the regioselective attachment to a terminal carbon of alkenes employed. Alkenes 126-133 NBL1, DAN family BMP antagonist Homo sapiens 6-9 28001395-1 2017 A new, one-pot cascade reaction of homopropargylic amines with electron-rich olefins is developed in the presence of Cu(OTf)2 and affords a series of octahydrofuro[3,2-c]pyrrolo[1,2-a]quinoline derivatives in yields of 38-80%. Alkenes 77-84 POU class 2 homeobox 2 Homo sapiens 117-125 28451211-3 2017 A variety of sp3-hybridized nucleophiles generated by in situ hydrozirconation of alkenes with the Schwartz reagent can be introduced, giving linear products bearing quaternary centres with up to 98% ee. Alkenes 82-89 Sp3 transcription factor Homo sapiens 13-16 27623160-2 2016 This transformation is supposed to proceed through the cascade formation of C(sp2)-C(sp2) and C(sp2)-N bonds via Pd(II)-catalyzed regioselective alkene migratory insertion, intramolecular radical addition, and oxidation sequential processes. Alkenes 145-151 Sp2 transcription factor Homo sapiens 76-81 27862789-0 2016 Hydroformylation of Olefins by a Rhodium Single-Atom Catalyst with Activity Comparable to RhCl(PPh3 )3. Alkenes 20-27 caveolin 1 Homo sapiens 95-99 27960316-3 2016 Deuterium labeling experiments suggest a syn-migratory insertion of the alkene into the Pd-O bond. Alkenes 72-78 synemin Homo sapiens 41-44 27775337-1 2016 We demonstrated here a successful development of the use of functional ionic liquids FIL 1 and FIL 3 for chemoselective detection of alkene gases measured by quartz crystal microbalance. Alkenes 133-139 interleukin 36 alpha Homo sapiens 85-90 27775337-2 2016 This detection of gaseous alkenes was achieved by the Diels-Alder [4 + 2] cycloadditions with FIL 1 and FIL 3 thin-coated on quartz chips. Alkenes 26-33 interleukin 36 alpha Homo sapiens 94-99 27714952-8 2016 Some preparations contain predominantly the alkene in C-2 and, therefore, an efficient detection method must include both primary metabolites M1 and M2. Alkenes 44-50 complement C2 Homo sapiens 54-57 27650477-1 2016 The first Pd-catalyzed multisite-selective acetoxylation reactions are disclosed at an unactivated alkene sp2 C-H bond versus secondary allylic sp3 C-H bond in cyclic olefins via the modulation of directing groups. Alkenes 99-105 Sp2 transcription factor Homo sapiens 106-109 27978759-2 2016 In this transformation, the Cu(OTf)2 catalyst plays a key role in the conversion of alkyne moiety into an alkene-type moiety, which means that the dienyne reactant is converted into a triene-type substrate. Alkenes 106-112 POU class 2 homeobox 2 Homo sapiens 28-36 27934501-0 2016 Orthogonally Protected 1,2-Diols from Electron-Rich Alkenes Using Metal-Free Olefin syn-Dihydroxylation. Alkenes 52-59 synemin Homo sapiens 84-87 27934501-0 2016 Orthogonally Protected 1,2-Diols from Electron-Rich Alkenes Using Metal-Free Olefin syn-Dihydroxylation. Alkenes 77-83 synemin Homo sapiens 84-87 27934501-1 2016 A new method for the stereoselective metal-free syn-dihydroxylation of electron-rich olefins is reported, involving reaction with TEMPO/IBX in trifluoroethanol (TFE) or hexafluoroisopropanol (HFIP) and the addition of a suitable nucleophile. Alkenes 85-92 synemin Homo sapiens 48-51 27805325-0 2016 Corrigendum: Mutating a Highly Conserved Residue in Diverse Cytochrome P450s Facilitates Diastereoselective Olefin Cyclopropanation. Alkenes 108-114 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 60-75 27732000-3 2016 cis,cis-1,5-Cyclooctadiene was identified as the most effective sacrificial hydrogen acceptor for the dehydrogenative silylation of vinylarenes, which allows use of a nearly equimolar ratio of alkenes and silanes. Alkenes 193-200 suppressor of cytokine signaling 1 Homo sapiens 4-9 27623160-2 2016 This transformation is supposed to proceed through the cascade formation of C(sp2)-C(sp2) and C(sp2)-N bonds via Pd(II)-catalyzed regioselective alkene migratory insertion, intramolecular radical addition, and oxidation sequential processes. Alkenes 145-151 Sp2 transcription factor Homo sapiens 83-88 27623160-2 2016 This transformation is supposed to proceed through the cascade formation of C(sp2)-C(sp2) and C(sp2)-N bonds via Pd(II)-catalyzed regioselective alkene migratory insertion, intramolecular radical addition, and oxidation sequential processes. Alkenes 145-151 Sp2 transcription factor Homo sapiens 83-88 27569420-4 2016 Furthermore, the catalytic olefin hydrogenation activity of the Co(I) species was studied by using multinuclear and parahydrogen (p-H2) induced polarization (PHIP) transfer NMR studies to elucidate catalytically relevant intermediates, as well as to establish the role of the Co(I)-(H2) in the Co(I)/Co(III) redox cycle. Alkenes 27-33 mitochondrially encoded cytochrome c oxidase I Homo sapiens 276-281 27593893-3 2016 The outcomes of the feasible C H activation of olefin carbon (C-2) by iridium catalyst are compared with the reduction of the carbonyl group (C-3) by freshly prepared borodeuterides. Alkenes 47-53 complement C2 Homo sapiens 62-65 27569420-0 2016 Well-Defined Cobalt(I) Dihydrogen Catalyst: Experimental Evidence for a Co(I)/Co(III) Redox Process in Olefin Hydrogenation. Alkenes 103-109 mitochondrially encoded cytochrome c oxidase I Homo sapiens 72-77 27569420-4 2016 Furthermore, the catalytic olefin hydrogenation activity of the Co(I) species was studied by using multinuclear and parahydrogen (p-H2) induced polarization (PHIP) transfer NMR studies to elucidate catalytically relevant intermediates, as well as to establish the role of the Co(I)-(H2) in the Co(I)/Co(III) redox cycle. Alkenes 27-33 mitochondrially encoded cytochrome c oxidase III Homo sapiens 300-306 27569420-0 2016 Well-Defined Cobalt(I) Dihydrogen Catalyst: Experimental Evidence for a Co(I)/Co(III) Redox Process in Olefin Hydrogenation. Alkenes 103-109 mitochondrially encoded cytochrome c oxidase III Homo sapiens 78-84 27490459-3 2016 On Au(111), we find that the C(1)-C(5) cyclization is suppressed and that the C(1)-C(6) cyclization yields a highly strained bicyclic olefin whose surface chemistry was hitherto unknown. Alkenes 134-140 heterogeneous nuclear ribonucleoprotein C Homo sapiens 78-82 27569420-4 2016 Furthermore, the catalytic olefin hydrogenation activity of the Co(I) species was studied by using multinuclear and parahydrogen (p-H2) induced polarization (PHIP) transfer NMR studies to elucidate catalytically relevant intermediates, as well as to establish the role of the Co(I)-(H2) in the Co(I)/Co(III) redox cycle. Alkenes 27-33 mitochondrially encoded cytochrome c oxidase I Homo sapiens 64-69 27569420-4 2016 Furthermore, the catalytic olefin hydrogenation activity of the Co(I) species was studied by using multinuclear and parahydrogen (p-H2) induced polarization (PHIP) transfer NMR studies to elucidate catalytically relevant intermediates, as well as to establish the role of the Co(I)-(H2) in the Co(I)/Co(III) redox cycle. Alkenes 27-33 polyhomeotic homolog 2 Homo sapiens 130-134 27569420-4 2016 Furthermore, the catalytic olefin hydrogenation activity of the Co(I) species was studied by using multinuclear and parahydrogen (p-H2) induced polarization (PHIP) transfer NMR studies to elucidate catalytically relevant intermediates, as well as to establish the role of the Co(I)-(H2) in the Co(I)/Co(III) redox cycle. Alkenes 27-33 mitochondrially encoded cytochrome c oxidase I Homo sapiens 276-281 27490459-3 2016 On Au(111), we find that the C(1)-C(5) cyclization is suppressed and that the C(1)-C(6) cyclization yields a highly strained bicyclic olefin whose surface chemistry was hitherto unknown. Alkenes 134-140 complement C6 Homo sapiens 83-87 27457506-3 2016 This "[Fe(II) (L)(OTf)2 ]+H2 O2 " method is applicable to both (E)-alkenes and terminal alkenes (24 examples >80 % ee, up to 1 g scale). Alkenes 67-74 POU class 2 homeobox 2 Homo sapiens 18-23 27468433-0 2016 Intramolecular mobility of eta(5)-ligands in chiral zirconocene complexes and the enantioselectivity of alkene functionalization by organoaluminum compounds. Alkenes 104-110 endothelin receptor type A Homo sapiens 27-30 27438228-3 2016 As for electron-rich alkenes, reactions catalyzed by Ir(dF(CF3)ppy)2(dtbbpy)(PF6) were kinetic processes with high yields and short times. Alkenes 21-28 sperm associated antigen 17 Homo sapiens 77-80 27410720-2 2016 Zirconocene hydrochloride ([Cp2 ZrHCl]) is often the reagent of choice for accessing these intermediates but generates organozirconocenes only from alkenes and alkynes. Alkenes 148-155 ceruloplasmin Homo sapiens 28-31 27452528-1 2016 Mono(phosphine)-M (M-PR3; M = Rh and Ir) complexes selectively prepared by postsynthetic metalation of a porous triarylphosphine-based metal-organic framework (MOF) exhibited excellent activity in the hydrosilylation of ketones and alkenes, the hydrogenation of alkenes, and the C-H borylation of arenes. Alkenes 232-239 proteinase 3 Homo sapiens 21-24 27452528-1 2016 Mono(phosphine)-M (M-PR3; M = Rh and Ir) complexes selectively prepared by postsynthetic metalation of a porous triarylphosphine-based metal-organic framework (MOF) exhibited excellent activity in the hydrosilylation of ketones and alkenes, the hydrogenation of alkenes, and the C-H borylation of arenes. Alkenes 262-269 proteinase 3 Homo sapiens 21-24 27314834-2 2016 The typical Heck-type oxidative coupling that occurs when alkenes are used is avoided by choosing maleimide as an alkene, which cannot undergo beta-hydride elimination due to the unavailability of a syn-periplanar beta-hydrogen atom. Alkenes 58-65 synemin Homo sapiens 199-202 27295556-1 2016 We report the remarkable ability of 2,6-bis(1,2,3-triazol-4-yl)pyridine (btp) compounds 2 with appended olefin amide arms to self-template the formation of interlocked [2]catenane structures 3 in up to 50 % yield when subjected to olefin ring-closing metathesis in CH2 Cl2 . Alkenes 104-110 endogenous retrovirus group W member 5 Homo sapiens 269-272 27374767-2 2016 The phosphinylphosphination proceeds by the homolytic cleavage of the P(V) (O)-P(III) single bond of Ph2 P(O)PPh2 , followed by selective attack of the phosphinyl radical at the terminal position of the alkenes, and selective trapping of the resulting carbon radical by the phosphino group. Alkenes 203-210 relaxin 2 Homo sapiens 101-113 27314834-2 2016 The typical Heck-type oxidative coupling that occurs when alkenes are used is avoided by choosing maleimide as an alkene, which cannot undergo beta-hydride elimination due to the unavailability of a syn-periplanar beta-hydrogen atom. Alkenes 58-64 synemin Homo sapiens 199-202 27124271-2 2016 The thermochemical data obtained from Density Functional Theory (DFT) calculations and the analyses of the transition structures reveal that, between the two competing reactions, elimination (via E2) versus dissociative addition (via SN2), elimination is the kinetically controlled one and thus at room temperature, olefin is the major product. Alkenes 316-322 solute carrier family 38 member 5 Homo sapiens 234-237 27773949-4 2016 The key step in the synthesis is oxidative olefin cleavage of delta-tocotrienol to afford the chroman core of 1 with retention of chirality at the C-2 stereocenter. Alkenes 43-49 complement C2 Homo sapiens 147-150 27312114-1 2016 A new protocol for C-Se and C-N bond formation by the direct difunctionalization of alkenes is reported. Alkenes 84-91 choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity) Homo sapiens 19-23 26924395-3 2016 Interestingly, (IPr[double bond, length as m-dash]CH)NMe2 binds AuCl through an exocyclic olefin unit, while the softer phosphorus centers in (IPr[double bond, length as m-dash]CH)PR2 coordinate to yield Au-P linkages; thus the reported NHO-based ligands exhibit tunable binding modes to metals. Alkenes 90-96 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens 53-57 27226329-8 2016 Remarkably, eta(2) to eta(1) slippage degree on the alkene coordination mode is directly related to the regioselective outcome. Alkenes 52-58 DNA polymerase iota Homo sapiens 12-17 27258005-1 2016 The Rh(II) -catalyzed oxyamination and diamination of alkenes generate 1,2-amino alcohols and 1,2-diamines, respectively, in good to excellent yields and with complete regiocontrol. Alkenes 54-61 Rh blood group D antigen Homo sapiens 4-10 27062670-3 2016 If the alkyne is at the C11 position (and thus flanked by a gem-dimethyl group), RCEDYM reaction only proceeds in the presence of a trisubstituted olefin at C13, which disfavors the competing diene ring-closing metathesis reaction, to give the tricyclic core of Taxol 44. Alkenes 147-153 RNA polymerase III subunit K Homo sapiens 24-27 27062670-3 2016 If the alkyne is at the C11 position (and thus flanked by a gem-dimethyl group), RCEDYM reaction only proceeds in the presence of a trisubstituted olefin at C13, which disfavors the competing diene ring-closing metathesis reaction, to give the tricyclic core of Taxol 44. Alkenes 147-153 homeobox C13 Homo sapiens 157-160 27163055-3 2016 Herein, a "zipped" approach by alkene cross-metathesis into CBS inhibitor candidate synthesis is demonstrated. Alkenes 31-37 cystathionine beta synthase Rattus norvegicus 60-63 27043308-2 2016 Key strategies of this synthesis include Jamison protocol of trans-hydroalumination/allylation for installation of C18-C23 olefin moiety and intramolecular Heck coupling for macrocyclization. Alkenes 123-129 Bardet-Biedl syndrome 9 Homo sapiens 115-118 27076098-9 2016 For the initiation process, this shows that there is an alkene-dependent loss of precatalyst Ru1, but this does not directly produce the active catalyst. Alkenes 56-62 Scm like with four mbt domains 1 Homo sapiens 93-96 26968748-4 2016 Deuterium-labelling studies indicate the reactions proceed through syn-aminopalladation of the alkene and suggest that the control of syn- versus anti-aminopalladation pathways is important for asymmetric induction. Alkenes 95-101 synemin Homo sapiens 67-70 26968748-4 2016 Deuterium-labelling studies indicate the reactions proceed through syn-aminopalladation of the alkene and suggest that the control of syn- versus anti-aminopalladation pathways is important for asymmetric induction. Alkenes 95-101 synemin Homo sapiens 134-137 27050839-0 2016 Target Specific Tactics in Olefin Metathesis: Synthetic Approach to cis-syn-cis-Triquinanes and -Propellanes. Alkenes 27-33 synemin Homo sapiens 72-75 27043308-2 2016 Key strategies of this synthesis include Jamison protocol of trans-hydroalumination/allylation for installation of C18-C23 olefin moiety and intramolecular Heck coupling for macrocyclization. Alkenes 123-129 nucleolin Homo sapiens 119-122 27050839-1 2016 A concise and simple synthetic approach to cis-syn-cis-triquinanes and -propellanes has been demonstrated via olefin metathesis starting with exo-nadic anhydride. Alkenes 110-116 synemin Homo sapiens 21-24 26634234-5 2016 The X-ray structures of E-1a, E-1b and E-1c show a slightly shortened N-C bond to the alkene moieties. Alkenes 86-92 branched chain keto acid dehydrogenase E1 subunit beta Homo sapiens 30-34 26634234-5 2016 The X-ray structures of E-1a, E-1b and E-1c show a slightly shortened N-C bond to the alkene moieties. Alkenes 86-92 small nucleolar RNA, H/ACA box 73B Homo sapiens 39-43 26948413-2 2016 The presence of a fluorinated solvent is essential for the success of these reactions which form unsymmetrical tri- and tetrasubstituted cyclobutanes through a heterodimerization process involving two different alkenes. Alkenes 211-218 tRNA-Ile (anticodon AAT) 9-1 Homo sapiens 104-107 26854284-1 2016 The directed chemoselective hydrogenation of olefins has been established by using iridium(I) catalysts, which feature a tuned NHC/phosphine ligand combination. Alkenes 45-52 high mobility group nucleosomal binding domain 4 Homo sapiens 127-130 26921118-2 2016 Propensity of the carbinol toward dehydration to yield the corresponding alkene, BMS-779788-ALK, was evaluated. Alkenes 73-79 ALK receptor tyrosine kinase Homo sapiens 92-95 27033405-2 2016 Although many methods are now available for the formation of C(sp(2))-C(sp(3)) and C(sp(3))-C(sp(3)) bonds via transition metal-catalyzed cross-coupling of alkyl organometallic reagents, direct use of readily available olefins in a formal fashion of hydrocarbonation to make C(sp(2))-C(sp(3)) and C(sp(3))-C(sp(3)) bonds remains to be developed. Alkenes 219-226 regulator of calcineurin 2 Homo sapiens 61-68 26863099-2 2016 The developed protocol introduces pentafulvenes as nonsymmetrical alkenes for the hydroheteroarylation reaction, providing alkylidenecyclopentenylation at the C-3 position of indoles and the C-2 position of pyrrole. Alkenes 66-73 complement C3 Homo sapiens 159-162 26822161-4 2016 The generated five coordinate cations derived from 2-9 via addition of two equivalents of BCl3 were evaluated in standard preliminary tests for olefin metathesis catalysis. Alkenes 144-150 BCL3 transcription coactivator Homo sapiens 90-94 26863099-2 2016 The developed protocol introduces pentafulvenes as nonsymmetrical alkenes for the hydroheteroarylation reaction, providing alkylidenecyclopentenylation at the C-3 position of indoles and the C-2 position of pyrrole. Alkenes 66-73 complement C2 Homo sapiens 191-194 26816269-0 2016 Mononuclear Nonheme High-Spin Iron(III)-Acylperoxo Complexes in Olefin Epoxidation and Alkane Hydroxylation Reactions. Alkenes 64-70 spindlin 1 Homo sapiens 25-29 26690878-0 2016 Mutating a Highly Conserved Residue in Diverse Cytochrome P450s Facilitates Diastereoselective Olefin Cyclopropanation. Alkenes 95-101 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 47-62 26822193-2 2016 The use of mild terminal reductants (Zn or Et2 Zn) confers significant functional-group tolerance, and the catalyst accommodates structurally and electronically diverse alkenes. Alkenes 169-176 endothelin 2 Homo sapiens 43-46 26816269-1 2016 Mononuclear nonheme high-spin iron(III)-acylperoxo complexes bearing an N-methylated cyclam ligand were synthesized, spectroscopically characterized, and investigated in olefin epoxidation and alkane hydroxylation reactions. Alkenes 170-176 spindlin 1 Homo sapiens 25-29 26732649-0 2016 Spin-Selective Generation of Triplet Nitrenes: Olefin Aziridination through Visible-Light Photosensitization of Azidoformates. Alkenes 47-53 spindlin 1 Homo sapiens 0-4 26836399-1 2016 A palladium-catalyzed tandem C-Br/C-H functionalization and cyclization of alkenes with organohalides is reported. Alkenes 75-82 carbonyl reductase 1 Homo sapiens 29-33 26720313-5 2016 The catalytic epoxidation of olefins by other oxidants, such as peracids, alkyl hydroperoxides, and iodosylbenzene, is also affected by the presence of H2SO4; product yields and enantioselectivities are high and similar irrespective of the oxidants in the presence of H2SO4, suggesting that a common epoxidizing intermediate is generated in the reactions of [Mn(II)(Dbp-MCP)](2+) and the oxidants. Alkenes 29-36 D-box binding PAR bZIP transcription factor Homo sapiens 366-369 26743540-3 2016 The reaction mechanism involves distinct roles of two Lewis basic sites, P and P=O, with P+ Br serving as a fine-tuning element for substrate fixation in the chiral environment, and P+ OBr as the Br+ transfer agent to the olefin. Alkenes 222-228 leptin receptor Homo sapiens 185-188 26720313-5 2016 The catalytic epoxidation of olefins by other oxidants, such as peracids, alkyl hydroperoxides, and iodosylbenzene, is also affected by the presence of H2SO4; product yields and enantioselectivities are high and similar irrespective of the oxidants in the presence of H2SO4, suggesting that a common epoxidizing intermediate is generated in the reactions of [Mn(II)(Dbp-MCP)](2+) and the oxidants. Alkenes 29-36 CD46 molecule Homo sapiens 370-373 26272248-2 2016 We developed a simple and efficient approach based on single photon ionization time-of-flight mass spectrometry (SPI-TOFMS) combined with online ozonolysis to identify and quantify the linear olefin double bond positional isomers. Alkenes 192-198 chromogranin A Homo sapiens 113-116 26639021-1 2016 We have developed a novel and simple protocol for the direct incorporation of a difluoromethyl (CF2 H) group into alkenes by visible-light-driven photoredox catalysis. Alkenes 114-121 ATPase H+ transporting accessory protein 1 Homo sapiens 96-99 26639021-3 2016 The well-designed photoredox system achieves synthesis of not only beta-CF2 H-substituted alcohols but also ethers and an ester from alkenes through solvolytic processes. Alkenes 133-140 ATPase H+ transporting accessory protein 1 Homo sapiens 72-75 26639021-4 2016 The present method allows a single-step and regioselective formation of C(sp(3))-CF2 H and C(sp(3))-O bonds from C=C moiety in alkenes, such as hydroxydifluoromethylation, regardless of terminal or internal alkenes. Alkenes 127-134 ATPase H+ transporting accessory protein 1 Homo sapiens 81-84 26639021-4 2016 The present method allows a single-step and regioselective formation of C(sp(3))-CF2 H and C(sp(3))-O bonds from C=C moiety in alkenes, such as hydroxydifluoromethylation, regardless of terminal or internal alkenes. Alkenes 207-214 ATPase H+ transporting accessory protein 1 Homo sapiens 81-84 26608162-1 2016 New ruthenium Grubbs" and Hoveyda-Grubbs" second generation catalysts bearing N-alkyl/N-isopropylphenyl N-heterocyclic carbene (NHC) ligands with syn or anti backbone configuration were obtained and compared in model olefin metathesis reactions. Alkenes 217-223 synemin Homo sapiens 146-149 26272248-4 2016 The aldehydes were then detected by SPI-TOFMS to achieve unique spectrometric "fingerprints" for each linear olefin to successfully identify the isomeric ones. Alkenes 109-115 chromogranin A Homo sapiens 36-39 26272248-7 2016 These results demonstrate that the online ozonolysis SPI-TOFMS has the potential for real-time monitoring of catalytic olefin synthetic reactions. Alkenes 119-125 chromogranin A Homo sapiens 53-56 26633338-1 2015 The intramolecular [3+2] cycloaddition (32CA) of alkene-tethered alpha-silyloxydiazoalkanes provides variable stereoselectivity in generating bicyclic pyrazolines where the silyloxy group is either syn or anti to the newly formed pyrazoline ring. Alkenes 49-55 synemin Homo sapiens 198-201 26365723-2 2016 Three alkenes, (acridin-4-yl)-CH=CH-R (R = COOCH3, Ph, and CONH2), reacted with three BNO dipoles (2,4,6-trimethoxy, 2,4,6-trimethyl, 2,6-dichloro) to give pairs of target isoxazolines with acridine bound to C-4 or C-5 carbon of the isoxazoline (denoted as 4-Acr or 5-Acr). Alkenes 6-13 complement C4A (Rodgers blood group) Homo sapiens 208-211 26365723-2 2016 Three alkenes, (acridin-4-yl)-CH=CH-R (R = COOCH3, Ph, and CONH2), reacted with three BNO dipoles (2,4,6-trimethoxy, 2,4,6-trimethyl, 2,6-dichloro) to give pairs of target isoxazolines with acridine bound to C-4 or C-5 carbon of the isoxazoline (denoted as 4-Acr or 5-Acr). Alkenes 6-13 complement C5 Homo sapiens 215-218 26365723-2 2016 Three alkenes, (acridin-4-yl)-CH=CH-R (R = COOCH3, Ph, and CONH2), reacted with three BNO dipoles (2,4,6-trimethoxy, 2,4,6-trimethyl, 2,6-dichloro) to give pairs of target isoxazolines with acridine bound to C-4 or C-5 carbon of the isoxazoline (denoted as 4-Acr or 5-Acr). Alkenes 6-13 acrosin Homo sapiens 259-262 26365723-2 2016 Three alkenes, (acridin-4-yl)-CH=CH-R (R = COOCH3, Ph, and CONH2), reacted with three BNO dipoles (2,4,6-trimethoxy, 2,4,6-trimethyl, 2,6-dichloro) to give pairs of target isoxazolines with acridine bound to C-4 or C-5 carbon of the isoxazoline (denoted as 4-Acr or 5-Acr). Alkenes 6-13 acrosin Homo sapiens 268-271 26383135-2 2015 Alkenes are obtained simply by mixing [Ph3 PCH3 ][CH3 OCO2 ] and the carbonyl and heating in a solvent (no base, no halides, and no inorganic byproducts). Alkenes 0-7 CLAM Homo sapiens 43-47 26352340-2 2015 With the combination of Cu(OTf)2 and I2, a variety of terminal alkenes underwent oxidative coupling reaction with various diaryl disulfides successfully to afford the corresponding E-vinyl sulfides in moderate to good yields. Alkenes 63-70 POU class 2 homeobox 2 Homo sapiens 24-32 26503048-0 2015 Rhodium-catalysed syn-carboamination of alkenes via a transient directing group. Alkenes 40-47 synemin Homo sapiens 18-21 26503048-5 2015 Here we describe the rhodium-catalysed carboamination of alkenes at the same (syn) face of a double bond, initiated by a carbon-hydrogen activation event that uses enoxyphthalimides as the source of both the carbon and the nitrogen functionalities. Alkenes 57-64 synemin Homo sapiens 78-81 26390300-3 2015 Characterization of catalysts using UV-Vis and NMR indicated that adding Sc(OTf)3 to the acetonitrile solution of Pd(OAc)2 generates a new Pd(ii)/Sc(iii) bimetallic complex having a diacetate bridge which serves as the key active species for Wacker-type oxidation and olefin isomerization. Alkenes 268-274 POU class 5 homeobox 1 Homo sapiens 73-81 26344643-1 2015 Density functional theory investigations reveal that the intramolecular additions of N-CN bonds to alkenes proceed in a novel asynchronous and concerted mechanism, while the intramolecular addition of O-CN bonds to alkenes may occur by both concerted and stepwise pathways. Alkenes 215-222 bone gamma-carboxyglutamate protein Homo sapiens 201-205 26436557-1 2015 The linear C15 alkene, 1-pentadecene, was reacted with NO3 radicals in a Teflon environmental chamber and yields of secondary organic aerosol (SOA) and particulate beta-hydroxynitrates, beta-carbonylnitrates, and organic peroxides (beta-nitrooxyhydroperoxides + dinitrooxyperoxides) were quantified using a variety of methods. Alkenes 15-21 placenta associated 8 Homo sapiens 11-14 26436557-1 2015 The linear C15 alkene, 1-pentadecene, was reacted with NO3 radicals in a Teflon environmental chamber and yields of secondary organic aerosol (SOA) and particulate beta-hydroxynitrates, beta-carbonylnitrates, and organic peroxides (beta-nitrooxyhydroperoxides + dinitrooxyperoxides) were quantified using a variety of methods. Alkenes 15-21 NBL1, DAN family BMP antagonist Homo sapiens 55-58 26434364-4 2015 Key elements in these total syntheses include: (1) FeCl3-catalyzed cationic cascade cyclization to construct podocarpane-type skeleton; (2) Mn(III)/Co(II)-catalyzed radical hydroxylation of alkene with high regio-, diastereo-, and chemoselectivities; (3) and a ketal-deprotection/lactone-opening/deprotonation/lactonization cascade. Alkenes 190-196 mitochondrially encoded cytochrome c oxidase II Homo sapiens 148-153 26726447-3 2015 Finally, the olefin-conjugated AuNFs were encapsulated with P(NIPAM-co-AAC) hydrogels via a radical polymerization reaction with co-monomer ratio of [NIPAM:AAc = 91:9 wt%]. Alkenes 13-19 glycine-N-acyltransferase Homo sapiens 71-74 26449465-2 2015 This dichotomy in product distribution was correlated to the efficiency in attaining syn-coplanarity of olefin-inserted 7-membered iridacycles. Alkenes 104-110 synemin Homo sapiens 85-88 26311172-1 2015 This report introduces N-methylpyrrolidone hydroperoxide (NMPOOH)/base as an excellent reagent system for hydroxy-directed syn selective epoxidation of electron-deficient olefins, characterized by high diastereoselectivity, short reaction times and remarkable chemoselectivity, especially in presence of oxidatively labile nitrogen or sulfur atoms. Alkenes 171-178 synemin Homo sapiens 123-126 26726447-3 2015 Finally, the olefin-conjugated AuNFs were encapsulated with P(NIPAM-co-AAC) hydrogels via a radical polymerization reaction with co-monomer ratio of [NIPAM:AAc = 91:9 wt%]. Alkenes 13-19 glycine-N-acyltransferase Homo sapiens 156-159 26664596-1 2015 During a Ru-catalyzed reaction of an olefin with an alkylidene moiety that leads to a metallacycle intermediate, the cis insertion of the olefin can occur from two different directions, namely side and bottom with respect to the phosphine or N-heterocyclic ligand (NHC), depending on the first or second generation Grubbs catalyst. Alkenes 37-43 high mobility group nucleosomal binding domain 4 Homo sapiens 242-263 26664596-1 2015 During a Ru-catalyzed reaction of an olefin with an alkylidene moiety that leads to a metallacycle intermediate, the cis insertion of the olefin can occur from two different directions, namely side and bottom with respect to the phosphine or N-heterocyclic ligand (NHC), depending on the first or second generation Grubbs catalyst. Alkenes 138-144 high mobility group nucleosomal binding domain 4 Homo sapiens 242-263 26664596-1 2015 During a Ru-catalyzed reaction of an olefin with an alkylidene moiety that leads to a metallacycle intermediate, the cis insertion of the olefin can occur from two different directions, namely side and bottom with respect to the phosphine or N-heterocyclic ligand (NHC), depending on the first or second generation Grubbs catalyst. Alkenes 138-144 high mobility group nucleosomal binding domain 4 Homo sapiens 265-268 26664596-1 2015 During a Ru-catalyzed reaction of an olefin with an alkylidene moiety that leads to a metallacycle intermediate, the cis insertion of the olefin can occur from two different directions, namely side and bottom with respect to the phosphine or N-heterocyclic ligand (NHC), depending on the first or second generation Grubbs catalyst. Alkenes 37-43 high mobility group nucleosomal binding domain 4 Homo sapiens 265-268 26250789-3 2015 The potential of this strategy was further demonstrated by the rapid synthesis of a cyclooxygenase-2 inhibitor as well as the success of employing electron-deficient alkenes and imines as the reaction partners. Alkenes 166-173 prostaglandin-endoperoxide synthase 2 Homo sapiens 84-100 26333527-8 2015 Furthermore, NBL IL-10, IL-13, GM-CSF and IFNgamma demonstrated positive associations with breath alkanes and alkenes. Alkenes 110-117 interleukin 10 Homo sapiens 17-22 26333527-8 2015 Furthermore, NBL IL-10, IL-13, GM-CSF and IFNgamma demonstrated positive associations with breath alkanes and alkenes. Alkenes 110-117 colony stimulating factor 2 Homo sapiens 31-37 26333527-8 2015 Furthermore, NBL IL-10, IL-13, GM-CSF and IFNgamma demonstrated positive associations with breath alkanes and alkenes. Alkenes 110-117 interferon gamma Homo sapiens 42-50 26716319-6 2015 The phosphated-alumina catalysts were active for the dimerization of isobutene in mild conditions and 100% selectivitiy to C8= olefins was reached without the presence of olefinic compounds with higher molecular weight (trimers, tetramers). Alkenes 127-134 homeobox C8 Homo sapiens 123-126 26120767-1 2015 A photoredox catalyzed aminodifluoromethylation of unactivated alkenes has been developed in which HCF2SO2Cl is used as the HCF2 radical source. Alkenes 63-70 host cell factor C2 Homo sapiens 99-103 26121618-2 2015 We herein address this issue by successfully incorporating a wide variety of functionalized alkynes and electron-deficient olefins into the unactivated sp(3) C-H bond of pivalic acid derivatives with excellent syn- and linear- selectivity. Alkenes 123-130 synemin Homo sapiens 210-213 26035311-3 2015 By switching the prenucleated metals to form robust Co-Pd or Co-Cu bimetallic nanocatalysts, the selectivity of CO hydrogenation could be adjusted purposely towards heavy paraffins, light olefins or oxygenates. Alkenes 188-195 COPD Homo sapiens 52-57 26126185-0 2015 cis-1,2-Aminohydroxylation of Alkenes Involving a Catalytic Cycle of Osmium(III) and Osmium(V) Centers: Os(V)(O)(NHTs) Active Oxidant with a Macrocyclic Tetradentate Ligand. Alkenes 30-37 cytokine inducible SH2 containing protein Homo sapiens 0-5 26018983-4 2015 The next step is a nucleophilic attack on the olefin carbon of SylA by the negatively charged Thr1-O(gamma) atom. Alkenes 46-52 thyroid hormone receptor beta Homo sapiens 94-98 26018983-5 2015 The last step is a proton transfer from Thr1-N(z) to another olefin carbon of SylA to complete the inhibition reaction process. Alkenes 61-67 thyroid hormone receptor beta Homo sapiens 40-44 26030726-2 2015 Glucose oxidase and lactase were readily immobilized (i.e., printing time 2 min) on alkene terminated self-assembled monolayers on glass as demonstrated by X-ray photoelectron spectroscopy and fluorescence microscopy. Alkenes 84-90 lactase Homo sapiens 20-27 26030520-3 2015 Optimized conditions for generating tertiary radicals from N-(acyloxy)phthalimide derivatives of tertiary carboxylic acids by visible-light irradiation in the presence of 1 mol % of commercially available Ru(bpy)3(PF6)2, diethyl 1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate (8), and i-Pr2NEt and their coupling in dichloromethane at room temperature with alkene acceptors were developed. Alkenes 361-367 sperm associated antigen 17 Homo sapiens 214-217 25970139-8 2015 In the case of SF2, a sulfur lone pair can transfer charge into the pi* MOs of the alkene, a back-transfer which is more difficult for SF4. Alkenes 83-89 serine and arginine rich splicing factor 1 Homo sapiens 15-18 26139944-0 2015 Room Temperature Activation of Aryloxysulfonyl Azides by [Co(II)(TPP)] for Selective Radical Aziridination of Alkenes via Metalloradical Catalysis. Alkenes 110-117 mitochondrially encoded cytochrome c oxidase II Homo sapiens 58-63 26010715-1 2015 Generated in situ from air-stable cobalt precursors or readily synthesized using NaHBEt3, (PPh3)3CoH(N2) was found to be an effective catalyst for the hydroboration of alkenes. Alkenes 168-175 caveolin 1 Homo sapiens 91-95 26010715-2 2015 Unlike previous base-metal catalysts for alkene isomerization-hydroboration which favor the incorporation of boron at terminal positions, (PPh3)3CoH(N2) promotes boron incorporation adjacent to pi-systems even in substrates where the alkene is at a remote position, enabling a unique route to 1,1-diboron compounds from alpha,omega-dienes. Alkenes 234-240 caveolin 1 Homo sapiens 139-143 25970139-8 2015 In the case of SF2, a sulfur lone pair can transfer charge into the pi* MOs of the alkene, a back-transfer which is more difficult for SF4. Alkenes 83-89 SURP and G-patch domain containing 1 Homo sapiens 135-138 26855604-2 2015 The principal indoor source of O3 is air exchange, while OH and NO3 formation are considered as primarily from O3 reactions with alkenes and nitrogen dioxide (NO2), respectively. Alkenes 129-136 NBL1, DAN family BMP antagonist Homo sapiens 64-67 25879801-3 2015 A novel electron-deficient olefin ligand, Fro-DO, proved crucial for achieving high rates and chemoselectivity for C-C bond formation over beta-H elimination. Alkenes 27-33 dishevelled binding antagonist of beta catenin 1 Homo sapiens 42-48 25826004-2 2015 The mild reaction conditions and high degree of functional group compatibility as demonstrated with substrates bearing heterocycles, olefins, and substituted aromatic groups, renders this technique highly valuable for the synthesis of a variety of cis-2,3-disubstituted indolines in high yield and enantioeselectivity. Alkenes 133-140 suppressor of cytokine signaling 2 Homo sapiens 248-253 25707447-1 2015 A novel CBr4-mediated dehydrogenative Povarov/aromatization tandem reaction of glycine derivatives with alkenes, leading to complex quinoline derivatives, and a CBr4-mediated dehydrogenative C-H functionalization of N-aryl tetrahydroisoquinolines with nucleophiles to form C-C and C-P bonds are reported. Alkenes 104-111 carbonyl reductase 4 Homo sapiens 8-12 25860622-0 2015 Iron-Catalyzed Oxidative C-H/C-H Cross-Coupling between Electron-Rich Arenes and Alkenes. Alkenes 81-88 churchill domain containing 1 Homo sapiens 25-32 25860622-1 2015 A novel oxidative C-H/C-H cross-coupling reaction between electron-rich arenes and alkenes is established utilizing FeCl3 as the catalyst and DDQ as the oxidant. Alkenes 83-90 churchill domain containing 1 Homo sapiens 18-25 25727074-0 2015 Copper/palladium synergistic catalysis for the syn- and anti-selective carboboration of alkenes. Alkenes 88-95 synemin Homo sapiens 17-20 25608933-7 2015 In addition, the use of group 4 NHC-complexes as catalysts in olefin (co)polymerization, ring-opening polymerization of rac-lactide, copolymerization of epoxides and CO2, as well as hydroamination/cyclization of aminoalkenes, is presented. Alkenes 62-68 high mobility group nucleosomal binding domain 4 Homo sapiens 32-35 25783181-1 2015 Titanaaziridines or eta(2)-imine titanium complexes are considered key intermediates of the titanium-catalyzed hydroaminoalkylation of alkenes. Alkenes 135-142 DNA polymerase iota Homo sapiens 20-25 25703541-6 2015 Replacing the central alkene bridge of FM4-64 with a thiophene does not substantially change the absorption, fluorescence or hyperpolarizability, whereas changing the vinylene-links to ethynylenes shifts the absorption and fluorescence to shorter wavelengths, and reduces the hyperpolarizability by about a factor of two. Alkenes 22-28 neuromedin U receptor 2 Homo sapiens 39-42 25656569-4 2015 The compounds featuring the structural motif of a distannametallacycle comprised of a [(NHC)2 M(0) ] fragment and Sn2 Trip4 represent rare higher congeners of the well-known olefin complexes. Alkenes 174-180 thyroid hormone receptor interactor 4 Homo sapiens 118-123 25581083-1 2015 Introduction of Ag(i) ions into a sulfonic acid functionalized MOF ((Cr)-MIL-101-SO3H) significantly enhances its interactions with olefin double bonds, leading to its much higher selectivities for the separation of C2H4-C2H6 and C3H6-C3H8 at room temperature over the original (Cr)-MIL-101-SO3H and other adsorbents at room temperature. Alkenes 132-138 lysine acetyltransferase 8 Homo sapiens 63-66 25702700-1 2015 The initial [2 + 2]-cycloadduct between a chromium aminocarbene and a tethered alkene undergoes a beta-hydrogen elimination very efficiently when triphenylphosphine is added as a ligand. Alkenes 79-85 amyloid beta precursor protein Homo sapiens 96-102 25291502-2 2015 The probe had exhibited a selective and sensitive response to the sulfite against other thirteen anions and biothiols (Cys, Hcy and GSH), through the nucleophilic addition of sulfite to the alkene of probe with the detection limit of 0.1 muM in HEPES (10 mM, pH 7.4) THF/H2O (1:1, v/v). Alkenes 190-196 latexin Homo sapiens 238-241 25634730-1 2015 Bronsted acid p-TsOH H2O-catalyzed hydrovinylation of styrenes with internal olefins alpha-oxo ketene dithioacetals was efficiently achieved in the presence of N-phenylselenophthalimide (N-PSP), regioselectively affording Markovnikov phenylselenative hydrovinylation products through PhSe transfer of the phenylseleno ketene dithioacetal intermediates. Alkenes 77-84 microseminoprotein beta Homo sapiens 189-192 25376860-0 2015 Titanium cis-1,2-diaminocyclohexane (cis-DACH) salalen catalysts for the asymmetric epoxidation of terminal non-conjugated olefins with hydrogen peroxide. Alkenes 123-130 cytokine inducible SH2 containing protein Homo sapiens 9-14 25557076-2 2015 The method implies the coupling of N-Boc-protected alkynamine derivatives and appropriate alkenes or alkynes in a process catalysed by a platinum/triflic acid catalytic binary system. Alkenes 90-97 BOC cell adhesion associated, oncogene regulated Homo sapiens 37-40 25557076-3 2015 This reaction is believed to proceed through a cascade process implying an initial platinum-catalysed cycloisomerization of the alkynamine derivative followed by a triflic acid promoted nucleophilic addition of the alkene or alkyne and trapping of the cationic species formed by the Boc group. Alkenes 215-221 BOC cell adhesion associated, oncogene regulated Homo sapiens 283-286 25538035-0 2015 Highly diastereoselective and enantioselective olefin cyclopropanation using engineered myoglobin-based catalysts. Alkenes 47-53 myoglobin Homo sapiens 88-97 25376860-0 2015 Titanium cis-1,2-diaminocyclohexane (cis-DACH) salalen catalysts for the asymmetric epoxidation of terminal non-conjugated olefins with hydrogen peroxide. Alkenes 123-130 dachshund family transcription factor 1 Homo sapiens 41-45 25378278-0 2015 The syn/anti-dichotomy in the palladium-catalyzed addition of nucleophiles to alkenes. Alkenes 78-85 synemin Homo sapiens 4-7 25179567-6 2014 The preference for cis-1,2-disubstituted product formation was also accounted for in terms of interaction between the hyperconjugatively delocalized SOMO and the alkene pi* orbital. Alkenes 162-168 suppressor of cytokine signaling 1 Homo sapiens 19-24 25260115-1 2014 The room-temperature oxidative C-H/C-H cross-couplings between (hetero)arenes and alkenes, coumarins or quinones have been reported by using a highly electrophilic palladium species [Pd(TFA)2], generated in situ from Pd(OAc)2 and TFA, as the catalyst and cheap (NH4)2S2O8 as the oxidant under air. Alkenes 82-89 churchill domain containing 1 Homo sapiens 31-38 26002734-1 2015 Hepatic microsomal cytochrome P450 (CYP) enzymes have broad and overlapping substrate specificity and catalyze a variety of monooxygenase reactions, including aliphatic and aromatic hydroxylations, N-hydroxylations, oxygenations of heteroatoms (N, S, P and I), alkene and arene epoxidations, dehalogenations, dehydrogenations and N-, O- and S-dealkylations. Alkenes 261-267 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 19-34 26002734-1 2015 Hepatic microsomal cytochrome P450 (CYP) enzymes have broad and overlapping substrate specificity and catalyze a variety of monooxygenase reactions, including aliphatic and aromatic hydroxylations, N-hydroxylations, oxygenations of heteroatoms (N, S, P and I), alkene and arene epoxidations, dehalogenations, dehydrogenations and N-, O- and S-dealkylations. Alkenes 261-267 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 36-39 25157629-4 2014 The observed Z-selectivity for the ring-opening metathesis (ROM) of COE is due to the large size of the aryloxide ligand, which forces both the alkylidene and the incoming cyclic olefin to be syn relative to the imido ligand. Alkenes 179-185 synemin Homo sapiens 192-195 25409491-5 2014 Incorporation of these olefins into the quinazoline templates produced potent EGFR inhibitors with improved safety and pharmacokinetic properties. Alkenes 23-30 epidermal growth factor receptor Homo sapiens 78-82 25277082-1 2014 A general method to form a C(SP(3))-SCF3 bond via copper-mediated oxidative trifluoromethylthiolation of unactivated alkenes with stable nucleophilic AgSCF3 was developed. Alkenes 117-124 Sp3 transcription factor Homo sapiens 27-34 25264262-0 2014 Alkene isomerisation catalysed by a ruthenium PNN pincer complex. Alkenes 0-6 pinin, desmosome associated protein Homo sapiens 46-49 25195874-0 2014 Rhodium(III)-catalyzed [3+2] annulation of 5-aryl-2,3-dihydro-1H-pyrroles with internal alkynes through C(sp2)-H/alkene functionalization. Alkenes 113-119 Sp2 transcription factor Homo sapiens 104-109 25254484-6 2014 A mixed singlet-triplet pathway is preferred in either the C-H insertion or alkene aziridination in the Rh2(NCH3CHO)4 entry that the triplet pathway is initially favorable in the rate-determining steps, and the resultant triplet intermediates would convert to a singlet reaction coordinate. Alkenes 76-82 Rh associated glycoprotein Homo sapiens 104-107 24735053-5 2014 Four possible pathways of styrene (Sub1) insertion step (pathways R1, S1, R2, and S2) were discussed; the calculated results indicate that pathways R1 and S2 are proposed to be two dominant alkene insertion pathways and that styrene tends to adopt apical coordination mode (A mode) to Rh center in pathways R1 and S2 compared to equatorial coordination mode (E mode) in pathways R2 and S1. Alkenes 190-196 SUB1 regulator of transcription Homo sapiens 35-39 25244703-0 2014 Direct intramolecular conjugate addition of simple alkenes to alpha,beta-unsaturated carbonyls catalyzed by Cu(OTf)2. Alkenes 51-58 POU class 2 homeobox 2 Homo sapiens 111-116 25181350-9 2014 The complex ((tBu)PBP)NiH (7) shows enhanced catalytic olefin hydrogenation activity when directly compared with its isoelectronic/isostructural analogues where the boryl unit is substituted by a phenyl or amine donor, a phenomenon that we posit is related to the strong trans influence exerted by the boryl ligand. Alkenes 55-61 polycystin 1, transient receptor potential channel interacting Homo sapiens 18-21