PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 24467325-0 2014 Elucidation of the molecular mechanism and the efficacy in vivo of a novel 1,4-benzoquinone that inhibits 5-lipoxygenase. quinone 75-91 arachidonate 5-lipoxygenase Homo sapiens 106-120 24467325-11 2014 CONCLUSIONS AND IMPLICATIONS: RF-Id represents a novel anti-inflammatory 1,4-benzoquinone that potently suppresses LT biosynthesis by direct inhibition of 5-LOX with effectiveness in vivo. quinone 73-89 arachidonate 5-lipoxygenase Homo sapiens 155-160 24631733-5 2014 All compounds containing a quinone moiety were able to inhibit p53-dependant transcriptional activity and exerted moderate inhibitory effects on HeLa cell colony formation. quinone 27-34 tumor protein p53 Homo sapiens 63-66 24530478-0 2014 alpha-Tocopheryl succinate pre-treatment attenuates quinone toxicity in prostate cancer PC3 cells. quinone 52-59 proprotein convertase subtilisin/kexin type 1 Homo sapiens 88-91 24471650-9 2014 Furthermore, structure-activity relationship analyses revealed that p-benzoquinone might be a crucial moiety of these inhibitors for inhibiting hDDC. quinone 68-82 dopa decarboxylase Homo sapiens 144-148 24631733-6 2014 Investigations of structure-activity relationships revealed that cytotoxicity depended on the type of substituent at C-2 of the quinone moiety, decreasing in the following order: methoxyderivatives > carbohydrate nonglucoside conjugates > hydroxyderivatives. quinone 128-135 complement C2 Homo sapiens 117-120 24444429-6 2014 Comparison of bacterial NDH-2 with the yeast NADH dehydrogenase (Ndi1) structure revealed non-overlapping binding sites for quinone and NADH in the bacterial enzyme. quinone 124-131 NADH-ubiquinone reductase (H(+)-translocating) NDE2 Saccharomyces cerevisiae S288C 24-29 24656803-7 2014 Initially the conversion of met- to deoxy-tyrosinase is brought about by a catechol that is indirectly formed from an ortho-quinone product of tyrosinase action. quinone 124-131 tyrosinase Homo sapiens 42-52 24656803-7 2014 Initially the conversion of met- to deoxy-tyrosinase is brought about by a catechol that is indirectly formed from an ortho-quinone product of tyrosinase action. quinone 124-131 tyrosinase Homo sapiens 143-153 24447770-1 2014 The aim of this study was to establish a methodology to analyze estrogen quinone-derived adducts, including 17beta-estradiol-2,3-quinone (E2-2,3-Q) and 17beta-estradiol-3,4-quinone (E2-3,4-Q), in human hemoglobin (Hb). quinone 73-80 transcription factor 4 Homo sapiens 138-142 24444429-6 2014 Comparison of bacterial NDH-2 with the yeast NADH dehydrogenase (Ndi1) structure revealed non-overlapping binding sites for quinone and NADH in the bacterial enzyme. quinone 124-131 NADH-ubiquinone reductase (H(+)-translocating) NDI1 Saccharomyces cerevisiae S288C 65-69 24447297-1 2014 Type II NADH-quinone oxidoreductase (NDH-2) catalyzes the transfer electrons from NADH to the quinone pool and plays an essential role in the oxidative phosphorylation system of Mycobacterium tuberculosis (Mtb). quinone 13-20 DExH-box helicase 9 Homo sapiens 37-42 24361488-2 2014 Our previous study has demonstrated that PCB quinone exposure causes severe cellular oxidative stress (Toxicology In Vitro 26 (2012) 841-848). quinone 45-52 pyruvate carboxylase Homo sapiens 41-44 24447297-3 2014 To fully establish the kinetic properties of this enzyme, we studied the interaction of Mtb NDH-2 with substrates, NADH, and various quinone analogues and their products in both membrane and soluble environments. quinone 133-140 DExH-box helicase 9 Homo sapiens 92-97 24361488-3 2014 There are no reports describing the ability of PCB quinone on Nrf2/ARE activation. quinone 51-58 NFE2 like bZIP transcription factor 2 Homo sapiens 62-66 24447297-4 2014 These studies, and comparative analyses of the kinetics with thio-NAD(+) and quinone electron acceptors, provided evidence that Mtb NDH-2 catalyzes the transfer electrons from NADH to quinone substrates by a nonclassical, two-site ping-pong kinetic mechanism whereby substrate quinones bind to a site that is distinct from the NADH-binding site. quinone 77-84 DExH-box helicase 9 Homo sapiens 132-137 24447297-4 2014 These studies, and comparative analyses of the kinetics with thio-NAD(+) and quinone electron acceptors, provided evidence that Mtb NDH-2 catalyzes the transfer electrons from NADH to quinone substrates by a nonclassical, two-site ping-pong kinetic mechanism whereby substrate quinones bind to a site that is distinct from the NADH-binding site. quinone 184-191 DExH-box helicase 9 Homo sapiens 132-137 24447297-5 2014 Furthermore, the effects of quinols on Mtb NDH-2 catalytic activity demonstrate the presence of two binding sites for quinone ligands, one favoring the reduced form and the other favoring the oxidized form. quinone 118-125 DExH-box helicase 9 Homo sapiens 43-48 24140869-1 2014 Human COQ6 encodes a monooxygenase which is responsible for the C5-hydroxylation of the quinone ring of coenzyme Q (CoQ). quinone 88-95 coenzyme Q6, monooxygenase Homo sapiens 6-10 23688079-5 2014 In particular, the cytochrome b subunit offers two distinct active sites that can be targeted for inhibition - the quinol oxidation site and the quinone reduction site. quinone 145-152 mitochondrially encoded cytochrome b Homo sapiens 19-31 21953684-7 2014 Benzene metabolites could not influence HaeIII DNMT activity except that 1,4-benzoquinone shows significantly inhibiting effect on enzymatic methylation reaction at concentrations of 5 muM (p < 0.05). quinone 73-89 latexin Homo sapiens 185-188 21953684-8 2014 These results suggest that benzene metabolites, hydroquinone, and 1,4-benzoquinone can disrupt global DNA methylation, and the potential epigenetic mechanism by which that global DNA hypomethylation induced by 1,4-benzoquinone may work through the inhibiting effects of DNMT activity at 10 muM (p < 0.05). quinone 66-82 DNA methyltransferase 1 Homo sapiens 270-274 21953684-8 2014 These results suggest that benzene metabolites, hydroquinone, and 1,4-benzoquinone can disrupt global DNA methylation, and the potential epigenetic mechanism by which that global DNA hypomethylation induced by 1,4-benzoquinone may work through the inhibiting effects of DNMT activity at 10 muM (p < 0.05). quinone 66-82 latexin Homo sapiens 290-293 21953684-8 2014 These results suggest that benzene metabolites, hydroquinone, and 1,4-benzoquinone can disrupt global DNA methylation, and the potential epigenetic mechanism by which that global DNA hypomethylation induced by 1,4-benzoquinone may work through the inhibiting effects of DNMT activity at 10 muM (p < 0.05). quinone 210-226 DNA methyltransferase 1 Homo sapiens 270-274 21953684-8 2014 These results suggest that benzene metabolites, hydroquinone, and 1,4-benzoquinone can disrupt global DNA methylation, and the potential epigenetic mechanism by which that global DNA hypomethylation induced by 1,4-benzoquinone may work through the inhibiting effects of DNMT activity at 10 muM (p < 0.05). quinone 210-226 latexin Homo sapiens 290-293 24144187-5 2013 Combined studies of tandem mass spectrometry and protein unfolding indicate the presence of quinone-promoted modifications in all of the Ngb derivatives analyzed (i.e., obtained employing either catecholamines or catechol estrogens as the source of the reactive species). quinone 92-99 neuroglobin Homo sapiens 137-140 24355130-4 2014 Our group has found two new quinone compounds that show excellent inhibition of breast tumor cells expressing HER2 or the trastuzumab resistant HER2 oncogenic isoform, HER2Delta16. quinone 28-35 erb-b2 receptor tyrosine kinase 2 Homo sapiens 110-114 24355130-4 2014 Our group has found two new quinone compounds that show excellent inhibition of breast tumor cells expressing HER2 or the trastuzumab resistant HER2 oncogenic isoform, HER2Delta16. quinone 28-35 erb-b2 receptor tyrosine kinase 2 Homo sapiens 144-148 24213144-0 2014 NF-kappaB signaling is increased in HD3 cells following exposure to 1,4-benzoquinone: role of reactive oxygen species and p38-MAPK. quinone 68-84 adapter molecule crk Gallus gallus 122-130 24213144-3 2014 As benzoquinone (BQ) is one of benzene"s most toxic metabolites, the objectives of this study were to determine whether ROS and p38-MAPK-mediated BQ-induced increased NF-kappaB activity. quinone 3-15 adapter molecule crk Gallus gallus 128-131 24213144-3 2014 As benzoquinone (BQ) is one of benzene"s most toxic metabolites, the objectives of this study were to determine whether ROS and p38-MAPK-mediated BQ-induced increased NF-kappaB activity. quinone 17-19 adapter molecule crk Gallus gallus 128-131 24144187-6 2013 Among protein residues, the highest reactivity of cysteines (Cys46, Cys55, and Cys120 in human Ngb) toward quinone species has been confirmed, and the dependence of the extent of protein modification on the method employed for catechol oxidation has been observed. quinone 107-114 neuroglobin Homo sapiens 95-98 23912160-5 2013 The amphipathic quinone coenzyme Q1 (CoQ1; 50 muM) mitigated the impact of rotenone on the adenine nucleotide balance, wherein mitigation was blocked by NAD(P)H-quinone oxidoreductase 1 or mitochondrial complex III inhibitors. quinone 16-23 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 153-185 24244442-1 2013 BACKGROUND AND PURPOSE: NAD(P)H: quinone oxidoreductase 1 (NQO1) mediated quinone reduction and subsequent UDP-glucuronosyltransferases (UGTs) catalyzed glucuronidation is the dominant metabolic pathway of tanshinone IIA (TSA), a promising anti-cancer agent. quinone 33-40 NAD(P)H quinone dehydrogenase 1 Homo sapiens 59-63 24085302-8 2013 Furthermore, high resolution MS and (1)H NMR analyses of the product generated from the incubation of menadione with recombinant UBIAD1 revealed that the hydroquinone, but not the quinone form of menadione, was an intermediate of the conversion. quinone 159-166 UbiA prenyltransferase domain containing 1 Rattus norvegicus 129-135 30708482-1 2013 The G143A mutation in cytb (cytochrome b gene) is associated with high levels of resistance to quinone outside inhibitor (QoI or strobilurin) fungicides that disrupt electron transport during cellular respiration (1). quinone 95-102 cytb Zymoseptoria tritici 28-40 23920313-1 2013 NAD(P)H:quinone oxidoreductase 1 (NQO1) is a phase II enzyme that participates in the detoxification of dopamine-derived quinone molecules and reactive oxygen species. quinone 8-15 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 23748533-5 2013 In contrast, upregulating Nrf2 activity, either by plasmid-mediated overexpression or treatment with the Nrf2 activator sulforaphane, increased the expression of ARE-dependent antioxidants, including NAD(P)H dehydrogenase, quinone 1 and glutathione, improved the expression of tight junction proteins, and restored the ability to form tight barriers in alveolar epithelial cells from HIV-1 transgenic rats. quinone 223-230 NFE2 like bZIP transcription factor 2 Rattus norvegicus 26-30 24059442-10 2013 Proteolytic digestion of the enzyme followed by LC/MS analysis indicated PCB-quinone- and PBQ-adducts at Cys55 and Cys199, as well as oxidation products at methionines in the protein. quinone 77-84 pyruvate carboxylase Homo sapiens 73-76 23871907-0 2013 Discovery and biological evaluation of novel 1,4-benzoquinone and related resorcinol derivatives that inhibit 5-lipoxygenase. quinone 45-61 arachidonate 5-lipoxygenase Homo sapiens 110-124 23836892-7 2013 Another arginine residue in the PSST subunit is hydroxylated and probably lies near to the quinone. quinone 91-98 NADH:ubiquinone oxidoreductase core subunit S7 Homo sapiens 32-36 24116043-4 2013 This study is an effort to understand how the redox state of the quinone pool(s) is sensed by the cell via the ArcB kinase. quinone 65-72 hypothetical protein Escherichia coli 111-115 24116043-8 2013 Furthermore, in batch cultures of a strain that contains ubiquinone as its only quinone species, we observed that the ArcA phosphorylation level closely followed the redox state of the ubiquinone/ubiquinol pool, much more strictly than it does in the wild type strain. quinone 60-67 arginine deiminase Escherichia coli 118-122 23748533-5 2013 In contrast, upregulating Nrf2 activity, either by plasmid-mediated overexpression or treatment with the Nrf2 activator sulforaphane, increased the expression of ARE-dependent antioxidants, including NAD(P)H dehydrogenase, quinone 1 and glutathione, improved the expression of tight junction proteins, and restored the ability to form tight barriers in alveolar epithelial cells from HIV-1 transgenic rats. quinone 223-230 NFE2 like bZIP transcription factor 2 Rattus norvegicus 105-109 23721565-4 2013 Here, we report the detection and mass spectral characterization of a glutathione conjugate of this sitaxentan quinone reactive metabolite that was trapped in vitro using mouse, rat, dog, and human liver microsomes supplemented with NADPH and glutathione and that was also observed in rat and human hepatocytes. quinone 111-118 2,4-dienoyl-CoA reductase 1 Homo sapiens 233-238 23846756-3 2013 In the in vitro anti-inflammatory effects test, quinone 1 was found to significantly inhibit the accumulation of the pro-inflammatory iNOS and COX-2 proteins of the LPS-stimulated RAW264.7 macrophage cells. quinone 48-55 nitric oxide synthase 2, inducible Mus musculus 134-138 23846756-3 2013 In the in vitro anti-inflammatory effects test, quinone 1 was found to significantly inhibit the accumulation of the pro-inflammatory iNOS and COX-2 proteins of the LPS-stimulated RAW264.7 macrophage cells. quinone 48-55 cytochrome c oxidase II, mitochondrial Mus musculus 143-148 23583257-0 2013 Quinone compounds regulate the level of ROS production by the NADPH oxidase Nox4. quinone 0-7 NADPH oxidase 4 Homo sapiens 76-80 23583257-2 2013 Nox4 oxidase activity is thought to be constitutive and regulated at the transcriptional level; however, we challenge this point of view and suggest that specific quinone derivatives could modulate this activity. quinone 163-170 NADPH oxidase 4 Homo sapiens 0-4 23583257-3 2013 In fact, we demonstrated a significant stimulation of Nox4 activity by 4 quinone derivatives (AA-861, tBuBHQ, tBuBQ, and duroquinone) observed in 3 different cellular models, HEK293E, T-REx , and chondrocyte cell lines. quinone 73-80 NADPH oxidase 4 Homo sapiens 54-58 23629000-3 2013 Hemin/G-quadruplex DNAenzyme significantly improved the catalysis of H(2)O(2) by oxidation of hydroquinone, resulting in an obvious reduction current of benzoquinone for miRNA-21 indirect detection. quinone 153-165 microRNA 21 Homo sapiens 170-178 23762435-5 2013 Incubation of estrogens with lactoperoxidase (LPO) and H2O2 resulted in formation of respective quinone methides (E1(E2)-QM). quinone 96-103 lactoperoxidase Homo sapiens 29-44 23762435-5 2013 Incubation of estrogens with lactoperoxidase (LPO) and H2O2 resulted in formation of respective quinone methides (E1(E2)-QM). quinone 96-103 lactoperoxidase Homo sapiens 46-49 23762435-5 2013 Incubation of estrogens with lactoperoxidase (LPO) and H2O2 resulted in formation of respective quinone methides (E1(E2)-QM). quinone 96-103 cystatin 12, pseudogene Homo sapiens 114-119 23865001-5 2013 This two-electron reduction of beta-Lap is mediated by NAD(P)H:quinone oxidoreductase (NQO1), which is known to mediate the reduction of many quinone compounds. quinone 63-70 NAD(P)H quinone dehydrogenase 1 Homo sapiens 87-91 23478802-0 2013 Benzoquinone reveals a cysteine-dependent desensitization mechanism of TRPA1. quinone 0-12 transient receptor potential cation channel subfamily A member 1 Homo sapiens 71-76 23377959-3 2013 The high antioxidant activity of both 3, 3"-DM-4, 4"-DHS and 3, 4-DHS may be due to the abstraction of the two hydrogen atoms of the para and ortho-position hydroxyls respectively, to form a quinone structure. quinone 191-198 DHS Homo sapiens 53-56 23377959-3 2013 The high antioxidant activity of both 3, 3"-DM-4, 4"-DHS and 3, 4-DHS may be due to the abstraction of the two hydrogen atoms of the para and ortho-position hydroxyls respectively, to form a quinone structure. quinone 191-198 DHS Homo sapiens 66-69 23501444-3 2013 We have therefore investigated, through LC-UV and LC-MS analysis the in vitro/in vivo metabolism of CA-1, have synthesized its reactive quinone metabolite Q1, and have evaluated its cytotoxic and antitubulinic activities. quinone 136-143 carbonic anhydrase 1 Homo sapiens 100-104 23478802-4 2013 We characterized the effects of the electrophilic arthropod defensive compound para-benzoquinone (pBQN) on the human TRPA1 channel. quinone 79-96 transient receptor potential cation channel subfamily A member 1 Homo sapiens 117-122 23478802-4 2013 We characterized the effects of the electrophilic arthropod defensive compound para-benzoquinone (pBQN) on the human TRPA1 channel. quinone 98-102 transient receptor potential cation channel subfamily A member 1 Homo sapiens 117-122 23478802-6 2013 We found that pBQN activates TRPA1 starting at 10 nM and peaking at 300 nM; higher concentrations caused rapid activation followed by a fast decline. quinone 14-18 transient receptor potential cation channel subfamily A member 1 Homo sapiens 29-34 23478802-8 2013 The current reduction we found at higher pBQN concentrations was a cysteine-dependent desensitization of TRPA1, and did not require prior activation. quinone 41-45 transient receptor potential cation channel subfamily A member 1 Homo sapiens 105-110 23478802-10 2013 Interestingly, following pBQN desensitization, wild-type TRPA1 had dramatically reduced response to the nonelectrophile agonist carvacrol, whereas the triple cysteine mutant TRPA1 retained its full response. quinone 25-29 transient receptor potential cation channel subfamily A member 1 Homo sapiens 57-62 23436706-3 2013 It has been shown to be at least tenfold more potent than combretastatin A4 (CA4) in terms of vascular shutdown, which correlates with its metabolism to reactive ortho-quinone species that are assumed to be directly cytotoxic in tumor cells. quinone 168-175 carbonic anhydrase 4 Homo sapiens 77-80 23303190-7 2013 Together, these findings support the hypothesis that CPLD38 impacts the stability of the cytochrome b6f complex and possibly plays a role in balancing redox inputs to the quinone pool from photosynthesis and chlororespiration. quinone 171-178 uncharacterized protein Chlamydomonas reinhardtii 53-59 23377082-6 2013 Interestingly, benzo-1,4-quinones displayed more inhibitory effects on DNMT activity than aldehydes. quinone 15-33 DNA methyltransferase 1 Homo sapiens 71-75 23338798-10 2013 The promising anti-inflammatory candidates based on the inhibition of DNA repair-related pols, such as pol lambda, by VKs quinone derivatives, such as NQ, are discussed. quinone 134-141 polymerase (DNA directed), lambda Mus musculus 115-125 23088752-2 2013 Multiple glutathione and beta-mercaptoethanol conjugates (a.k.a., adducts), derived from the trapping of quinone methide and quinone intermediates of capsaicin, its analogue nonivamide, and O-demethylated and aromatic hydroxylated metabolites thereof, were produced by human liver microsomes and individual recombinant human P450 enzymes. quinone 105-112 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 325-329 23088752-2 2013 Multiple glutathione and beta-mercaptoethanol conjugates (a.k.a., adducts), derived from the trapping of quinone methide and quinone intermediates of capsaicin, its analogue nonivamide, and O-demethylated and aromatic hydroxylated metabolites thereof, were produced by human liver microsomes and individual recombinant human P450 enzymes. quinone 125-132 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 325-329 23198810-4 2013 Fluorescence of the reporter dye is turned on by rapid removal of the quinone quencher, an event that immediately occurs only after highly selective, two-electron reduction of the sterically and conformationally restricted quinone substrate by the cancer-associated human NAD(P)H:quinone oxidoreductase isozyme 1 (hNQO1). quinone 70-77 NAD(P)H quinone dehydrogenase 1 Homo sapiens 314-319 23198810-4 2013 Fluorescence of the reporter dye is turned on by rapid removal of the quinone quencher, an event that immediately occurs only after highly selective, two-electron reduction of the sterically and conformationally restricted quinone substrate by the cancer-associated human NAD(P)H:quinone oxidoreductase isozyme 1 (hNQO1). quinone 223-230 NAD(P)H quinone dehydrogenase 1 Homo sapiens 314-319 23710334-2 2013 Previously, we have demonstrated that a quinone-based mimetic dipeptide, named DTNQ-Pro, induced differentiation of growing Caco-2 cells through inhibition of HSP70 and HSP90. quinone 40-47 heat shock protein family A (Hsp70) member 4 Homo sapiens 159-164 23748219-0 2013 Single-electron reduction of quinone and nitroaromatic xenobiotics by recombinant rat neuronal nitric oxide synthase. quinone 29-36 nitric oxide synthase 1 Rattus norvegicus 86-116 23252650-4 2013 Similarly, the effective quenching of the AgNCs by quinones enabled the detection of tyrosinase through the biocatalyzed oxidation of tyrosine, dopamine, or tyramine to the respective quinone products. quinone 51-58 tyrosinase Homo sapiens 85-95 23710334-2 2013 Previously, we have demonstrated that a quinone-based mimetic dipeptide, named DTNQ-Pro, induced differentiation of growing Caco-2 cells through inhibition of HSP70 and HSP90. quinone 40-47 heat shock protein 90 alpha family class A member 1 Homo sapiens 169-174 23546588-5 2013 Quinone toxicity in hepatocytes: CYPs require electrons supplied from NADPH-cytochrome P450 reductase (NPR) during the process of metabolism. quinone 0-7 cytochrome p450 oxidoreductase Homo sapiens 70-101 23467445-2 2013 NADPH quinone oxidoreductase 1 (NQO1) metabolizes the quinone structures contained in both amrubicin (AMR) and amrubicinol (AMR-OH). quinone 6-13 NAD(P)H quinone dehydrogenase 1 Homo sapiens 32-36 23546588-5 2013 Quinone toxicity in hepatocytes: CYPs require electrons supplied from NADPH-cytochrome P450 reductase (NPR) during the process of metabolism. quinone 0-7 cytochrome p450 oxidoreductase Homo sapiens 103-106 23546588-6 2013 NPR also provides electrons to quinone compounds, which compete with CYPs over electrons. quinone 31-38 cytochrome p450 oxidoreductase Homo sapiens 0-3 23472470-3 2013 In this study, twenty-three quinone compounds of plant origin were tested in vitro for their potential to inhibit leukotriene B4 (LTB4) biosynthesis in activated human neutrophil granulocytes with 5-lipoxygenase (5-LOX) activity. quinone 28-35 arachidonate 5-lipoxygenase Homo sapiens 197-211 23472470-8 2013 This process supports the biological data and suggested that, although the redox potential is responsible for the quinone"s activity on multiple targets, in the case of 5-LOX the molecular structure plays a vital role in the inhibition. quinone 114-121 arachidonate 5-lipoxygenase Homo sapiens 169-174 23903227-0 2013 Enhancement of quinone hepatotoxicity by cytochrome P450 inhibition. quinone 15-22 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 41-56 23903227-4 2013 A drug metabolizing enzyme, cytochrome P450 is closely involved in the hepatotoxicity of therapeutic agents in general, but quinone hepatotoxicity has been considered not to contribute to cytochrome P450 because the structure of quinone is not modified by cytochrome P450 and thus quinone compounds are thought to be metabolized mainly via a conjugation process. quinone 229-236 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 28-43 23903227-4 2013 A drug metabolizing enzyme, cytochrome P450 is closely involved in the hepatotoxicity of therapeutic agents in general, but quinone hepatotoxicity has been considered not to contribute to cytochrome P450 because the structure of quinone is not modified by cytochrome P450 and thus quinone compounds are thought to be metabolized mainly via a conjugation process. quinone 229-236 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 28-43 23903227-5 2013 However, we have recently shown that quinone hepatotoxicity is enhanced under conditions of cytochrome P450 inhibition, indicating clearly the involvement of cytochrome P450 in quinone hepatotoxicity. quinone 37-44 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 92-107 23903227-5 2013 However, we have recently shown that quinone hepatotoxicity is enhanced under conditions of cytochrome P450 inhibition, indicating clearly the involvement of cytochrome P450 in quinone hepatotoxicity. quinone 37-44 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 158-173 23903227-5 2013 However, we have recently shown that quinone hepatotoxicity is enhanced under conditions of cytochrome P450 inhibition, indicating clearly the involvement of cytochrome P450 in quinone hepatotoxicity. quinone 177-184 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 92-107 23903227-5 2013 However, we have recently shown that quinone hepatotoxicity is enhanced under conditions of cytochrome P450 inhibition, indicating clearly the involvement of cytochrome P450 in quinone hepatotoxicity. quinone 177-184 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 158-173 23903227-6 2013 Here, we revisit the generally accepted mechanisms of quinone hepatotoxicity and propose the importance of cytochrome P450 systems in quinone-induced hepatotoxicity on the basis of our recent work. quinone 134-141 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 107-122 23546588-7 2013 Inhibition of CYPs shifts NPR"s electron flow more to quinones, which accelerates the redox cycle to enhance ROS production and quinone toxicity. quinone 54-61 cytochrome p450 oxidoreductase Homo sapiens 26-29 23141909-7 2012 Dimer 40 showed an IC(50) value of 2.9 muM and could inhibit CDC25 activity without generating reactive oxygen species which is likely to occur with quinone-based inhibitors. quinone 149-156 cell division cycle 25C Homo sapiens 61-66 23170832-6 2012 These materials are found to be oligomers (GPC) with thermal stability (TGA) reaching 350 C. The greatest stabilities were found in the cases with X = F. Using a data bank of 8 X-ray structures of diimine derivatives, a relationship between the C N bond distance and the dihedral angle between the benzoquinone ring and the flanking phenyl planes is noted. quinone 299-311 glycophorin C (Gerbich blood group) Homo sapiens 43-46 23035985-0 2012 Quinone-induced activation of Keap1/Nrf2 signaling by aspirin prodrugs masquerading as nitric oxide. quinone 0-7 kelch like ECH associated protein 1 Homo sapiens 30-35 23035985-0 2012 Quinone-induced activation of Keap1/Nrf2 signaling by aspirin prodrugs masquerading as nitric oxide. quinone 0-7 NFE2 like bZIP transcription factor 2 Homo sapiens 36-40 22949654-2 2012 In various organisms, complex I can be replaced by the alternative NADH-quinone oxidoreductase (NDH-2), which catalyzes the transfer of an electron from NADH via FAD to quinone, without proton pumping. quinone 72-79 NADH-ubiquinone reductase (H(+)-translocating) NDE2 Saccharomyces cerevisiae S288C 96-101 23134532-3 2012 NQO1-mediated quinone reduction and subsequent glucuronidation is the predominant metabolic pathway for beta-Lap in humans; a pair of regioisomers (M1 and M2) of reduced beta-Lap glucuronides were the major metabolites found from human S9 incubations. quinone 14-21 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-4 23134532-3 2012 NQO1-mediated quinone reduction and subsequent glucuronidation is the predominant metabolic pathway for beta-Lap in humans; a pair of regioisomers (M1 and M2) of reduced beta-Lap glucuronides were the major metabolites found from human S9 incubations. quinone 14-21 LAP Homo sapiens 109-112 23134532-3 2012 NQO1-mediated quinone reduction and subsequent glucuronidation is the predominant metabolic pathway for beta-Lap in humans; a pair of regioisomers (M1 and M2) of reduced beta-Lap glucuronides were the major metabolites found from human S9 incubations. quinone 14-21 LAP Homo sapiens 175-178 23134532-6 2012 UGT1A7, UGT1A8, and UGT1A9 are the predominant isoforms responsible for the formation of M2 while UGT2B7 is the main isoform for M1, suggesting a regioselective glucuronidation of reduced quinone by UGTs. quinone 188-195 UDP glucuronosyltransferase family 1 member A7 Homo sapiens 0-6 23134532-6 2012 UGT1A7, UGT1A8, and UGT1A9 are the predominant isoforms responsible for the formation of M2 while UGT2B7 is the main isoform for M1, suggesting a regioselective glucuronidation of reduced quinone by UGTs. quinone 188-195 UDP glucuronosyltransferase family 1 member A9 Homo sapiens 20-26 23134532-6 2012 UGT1A7, UGT1A8, and UGT1A9 are the predominant isoforms responsible for the formation of M2 while UGT2B7 is the main isoform for M1, suggesting a regioselective glucuronidation of reduced quinone by UGTs. quinone 188-195 UDP glucuronosyltransferase family 2 member B7 Homo sapiens 98-104 23066705-12 2012 In contrast, the intense spectrum of Y257F(Int2)(HPCA) suggests the intermediate is most likely an HPCA quinone-Fe(II)-(hydro)peroxo species. quinone 104-111 fibroblast growth factor 3 Homo sapiens 43-47 22910835-8 2012 A linear response was obtained for studied quinone concentrations in the range of 0.05-50 muM for 1,4-naphthquinone and of 0.05-150 muM for 2-methyl-1,4-naphthoquinone (menadione) and 9,10-anthraquinone with detection limit (blank + 3SD) of 0.01 muM. quinone 43-50 latexin Homo sapiens 90-93 22910835-8 2012 A linear response was obtained for studied quinone concentrations in the range of 0.05-50 muM for 1,4-naphthquinone and of 0.05-150 muM for 2-methyl-1,4-naphthoquinone (menadione) and 9,10-anthraquinone with detection limit (blank + 3SD) of 0.01 muM. quinone 43-50 latexin Homo sapiens 132-135 22910835-8 2012 A linear response was obtained for studied quinone concentrations in the range of 0.05-50 muM for 1,4-naphthquinone and of 0.05-150 muM for 2-methyl-1,4-naphthoquinone (menadione) and 9,10-anthraquinone with detection limit (blank + 3SD) of 0.01 muM. quinone 43-50 latexin Homo sapiens 132-135 22960397-13 2012 With regard to CXCL12, treatment with BQ caused slight up-regulation and treatment with HQ led to down-regulation. quinone 38-40 C-X-C motif chemokine ligand 12 Homo sapiens 15-21 23047025-4 2012 We hypothesize that the cytotoxicity of CGQ in dicoumarol-treated hepatocytes was the result of inhibition of the NQO1 detoxification pathway, thus allowing more quinone to be metabolized towards the one-electron pathway to form reactive semiquinones and/or reactive oxygen species. quinone 162-169 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 114-118 23176470-4 2012 One of these cytochromes is CymA, a membrane-bound tetrahaem cytochrome localized in the periplasm that mediates the electron transfer between the quinone pool in the cytoplasmic membrane and several periplasmic proteins. quinone 147-154 cytochrome c Shewanella oneidensis MR-1 28-32 22925602-2 2012 9,10-Phenanthrenequinone (9,10-PQ), a major quinone in diesel exhaust particles, produces ROS in redox cycling following two-electron reduction by NAD(P)H:quinone oxidoreductase 1 (NQO1), which has been considered as a cause of its cyto- and genotoxicity. quinone 17-24 NAD(P)H quinone dehydrogenase 1 Homo sapiens 147-179 22925602-2 2012 9,10-Phenanthrenequinone (9,10-PQ), a major quinone in diesel exhaust particles, produces ROS in redox cycling following two-electron reduction by NAD(P)H:quinone oxidoreductase 1 (NQO1), which has been considered as a cause of its cyto- and genotoxicity. quinone 17-24 NAD(P)H quinone dehydrogenase 1 Homo sapiens 181-185 22949654-7 2012 Crucially, the structures of the Ndi1-NAD(+) and Ndi1-UQ2 complexes show overlapping binding sites for the NAD(+) and quinone substrates. quinone 118-125 NADH-ubiquinone reductase (H(+)-translocating) NDI1 Saccharomyces cerevisiae S288C 33-37 22949654-7 2012 Crucially, the structures of the Ndi1-NAD(+) and Ndi1-UQ2 complexes show overlapping binding sites for the NAD(+) and quinone substrates. quinone 118-125 NADH-ubiquinone reductase (H(+)-translocating) NDI1 Saccharomyces cerevisiae S288C 49-53 22855270-6 2012 The SAR analysis of quinone analogues suggested that the phenolic and carbonyl groups are the key structures contributing to their inhibitory activities against the STAT3 signaling. quinone 20-27 signal transducer and activator of transcription 3 Homo sapiens 165-170 22639088-1 2012 Cytochrome P450(BM3)-F87G catalyzed the oxidative defluorination of 4-fluorophenol, followed by reduction of the resulting benzoquinone to hydroquinone via the NADPH P450-reductase activity of the enzyme. quinone 123-135 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-19 22765283-0 2012 A reinvestigation of the dimer of para-benzoquinone and pyrimidine with MP2, CCSD(T), and DFT using functionals including those designed to describe dispersion. quinone 34-51 tryptase pseudogene 1 Homo sapiens 72-75 22634106-1 2012 An online immobilized glucose oxidase (GOx) capillary microreactor was developed based on an enzymatic redox reaction with 1,4-benzoquinone as an acceptor of electrons, replacing the molecular oxygen typically used in a GOx reaction to achieve direct ultraviolet detection without derivation. quinone 123-139 hydroxyacid oxidase 1 Homo sapiens 22-37 22634106-1 2012 An online immobilized glucose oxidase (GOx) capillary microreactor was developed based on an enzymatic redox reaction with 1,4-benzoquinone as an acceptor of electrons, replacing the molecular oxygen typically used in a GOx reaction to achieve direct ultraviolet detection without derivation. quinone 123-139 hydroxyacid oxidase 1 Homo sapiens 39-42 22634106-1 2012 An online immobilized glucose oxidase (GOx) capillary microreactor was developed based on an enzymatic redox reaction with 1,4-benzoquinone as an acceptor of electrons, replacing the molecular oxygen typically used in a GOx reaction to achieve direct ultraviolet detection without derivation. quinone 123-139 hydroxyacid oxidase 1 Homo sapiens 220-223 22813233-1 2012 A combination of picosecond and microsecond transient absorption dynamics reveals the involvement of two mechanisms by which 1,4-benzoquinone (BQ) induces the decay of the excited state of PbS quantum dots (QDs): (i) electron transfer to BQ molecules adsorbed to the surfaces of PbS QDs and (ii) collisionally gated electron transfer to freely diffusing BQ. quinone 125-141 cholinergic receptor muscarinic 3 Homo sapiens 189-192 22813233-1 2012 A combination of picosecond and microsecond transient absorption dynamics reveals the involvement of two mechanisms by which 1,4-benzoquinone (BQ) induces the decay of the excited state of PbS quantum dots (QDs): (i) electron transfer to BQ molecules adsorbed to the surfaces of PbS QDs and (ii) collisionally gated electron transfer to freely diffusing BQ. quinone 125-141 cholinergic receptor muscarinic 3 Homo sapiens 279-282 22813233-1 2012 A combination of picosecond and microsecond transient absorption dynamics reveals the involvement of two mechanisms by which 1,4-benzoquinone (BQ) induces the decay of the excited state of PbS quantum dots (QDs): (i) electron transfer to BQ molecules adsorbed to the surfaces of PbS QDs and (ii) collisionally gated electron transfer to freely diffusing BQ. quinone 143-145 cholinergic receptor muscarinic 3 Homo sapiens 189-192 22813233-1 2012 A combination of picosecond and microsecond transient absorption dynamics reveals the involvement of two mechanisms by which 1,4-benzoquinone (BQ) induces the decay of the excited state of PbS quantum dots (QDs): (i) electron transfer to BQ molecules adsorbed to the surfaces of PbS QDs and (ii) collisionally gated electron transfer to freely diffusing BQ. quinone 143-145 cholinergic receptor muscarinic 3 Homo sapiens 279-282 22813233-1 2012 A combination of picosecond and microsecond transient absorption dynamics reveals the involvement of two mechanisms by which 1,4-benzoquinone (BQ) induces the decay of the excited state of PbS quantum dots (QDs): (i) electron transfer to BQ molecules adsorbed to the surfaces of PbS QDs and (ii) collisionally gated electron transfer to freely diffusing BQ. quinone 238-240 cholinergic receptor muscarinic 3 Homo sapiens 189-192 22813233-1 2012 A combination of picosecond and microsecond transient absorption dynamics reveals the involvement of two mechanisms by which 1,4-benzoquinone (BQ) induces the decay of the excited state of PbS quantum dots (QDs): (i) electron transfer to BQ molecules adsorbed to the surfaces of PbS QDs and (ii) collisionally gated electron transfer to freely diffusing BQ. quinone 238-240 cholinergic receptor muscarinic 3 Homo sapiens 189-192 22813233-2 2012 Together, these two mechanisms quantitatively describe the quenching of photoluminescence upon addition of BQ to PbS QDs in dichloromethane solution. quinone 107-109 cholinergic receptor muscarinic 3 Homo sapiens 113-116 22813233-4 2012 The availability of a collisionally gated pathway improves the yield of electron transfer from PbS QDs to BQ by an average factor of 2.5 over that for static electron transfer alone. quinone 106-108 cholinergic receptor muscarinic 3 Homo sapiens 95-98 22573340-3 2012 By contrast, 1,4-benzoquinone site-specifically labels annexin V in minutes. quinone 13-29 annexin A5 Homo sapiens 55-64 22613176-6 2012 The results support a bioactivation process that involves formation of a hydroquinone metabolite that undergoes further oxidation to a quinone, which reacts with CYP2E1 nucleophilic residues. quinone 78-85 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 162-168 22694104-8 2012 On the basis of kinetic and spectroscopic data, we propose a chemical mechanism for the inactivation of the enzyme that starts with a reduction of the quinone ring of MMC by the selenolthiol active site of TrxR and a subsequent alkylation of the active site by the activated drug. quinone 151-158 peroxiredoxin 5 Homo sapiens 206-210 22547613-2 2012 The complex contains two distinct quinone-binding sites, the quinol oxidation site of the bc(1) complex (Q(o)) and the quinone reduction site (Q(i)), located on opposite sides of the membrane within cytochrome b. quinone 34-41 CYTB Plasmodium falciparum 199-211 22547613-2 2012 The complex contains two distinct quinone-binding sites, the quinol oxidation site of the bc(1) complex (Q(o)) and the quinone reduction site (Q(i)), located on opposite sides of the membrane within cytochrome b. quinone 119-126 CYTB Plasmodium falciparum 199-211 22027503-0 2012 Expression and methylation analysis of p15 and p16 in mouse bone marrow cells exposed to 1,4-benzoquinone. quinone 89-105 cyclin dependent kinase inhibitor 2B Mus musculus 39-42 22027503-0 2012 Expression and methylation analysis of p15 and p16 in mouse bone marrow cells exposed to 1,4-benzoquinone. quinone 89-105 cyclin dependent kinase inhibitor 2A Mus musculus 47-50 22027503-4 2012 To understand the mechanism of benzene-induced epigenetic variations, we investigated the expression and methylation patterns of CpG (phosphodiester bond between cytosine and guanine) islands in p15 and p16 promoter regions in 1,4-benzoquinone (1,4-BQ)-treated primary cultivated C57BL/6J mouse bone marrow cells in vitro. quinone 227-243 cyclin dependent kinase inhibitor 2B Mus musculus 195-198 22027503-4 2012 To understand the mechanism of benzene-induced epigenetic variations, we investigated the expression and methylation patterns of CpG (phosphodiester bond between cytosine and guanine) islands in p15 and p16 promoter regions in 1,4-benzoquinone (1,4-BQ)-treated primary cultivated C57BL/6J mouse bone marrow cells in vitro. quinone 227-243 cyclin dependent kinase inhibitor 2A Mus musculus 203-206 22027503-7 2012 After a 24-h exposure to 1,4-BQ at final concentrations of 0, 0.1, 1, and 10 mumol/L, the mRNA expression of p15 and p16 decreased with the increase in 1,4-BQ concentration. quinone 25-31 cyclin dependent kinase inhibitor 2B Mus musculus 109-112 22027503-7 2012 After a 24-h exposure to 1,4-BQ at final concentrations of 0, 0.1, 1, and 10 mumol/L, the mRNA expression of p15 and p16 decreased with the increase in 1,4-BQ concentration. quinone 25-31 cyclin dependent kinase inhibitor 2A Mus musculus 117-120 22027503-7 2012 After a 24-h exposure to 1,4-BQ at final concentrations of 0, 0.1, 1, and 10 mumol/L, the mRNA expression of p15 and p16 decreased with the increase in 1,4-BQ concentration. quinone 152-158 cyclin dependent kinase inhibitor 2B Mus musculus 109-112 22027503-7 2012 After a 24-h exposure to 1,4-BQ at final concentrations of 0, 0.1, 1, and 10 mumol/L, the mRNA expression of p15 and p16 decreased with the increase in 1,4-BQ concentration. quinone 152-158 cyclin dependent kinase inhibitor 2A Mus musculus 117-120 22209713-7 2012 In this review we will discuss the role of NQO1 in the sensitivity and resistance of human cancers to the quinone antitumor drugs mitomycin C, beta-lapachone and the benzoquinone ansamycin class of Hsp90 inhibitors including 17-AAG. quinone 106-113 NAD(P)H quinone dehydrogenase 1 Homo sapiens 43-47 22609468-0 2012 Cytotoxicity of quinone drugs on highly proliferative human leukemia T cells: reactive oxygen species generation and inactive shortened SOD1 isoform implications. quinone 16-23 superoxide dismutase 1 Homo sapiens 136-140 22551359-2 2012 Further oxidation of dihydroxy HBC with phenyliodine bis(trifluoroacetate) (PIFA) afforded tetraoxo-substituted HBC without any regioisomers, which can be considered as a pi-extended quinone. quinone 183-190 keratin 88, pseudogene Homo sapiens 31-34 22551359-2 2012 Further oxidation of dihydroxy HBC with phenyliodine bis(trifluoroacetate) (PIFA) afforded tetraoxo-substituted HBC without any regioisomers, which can be considered as a pi-extended quinone. quinone 183-190 keratin 88, pseudogene Homo sapiens 112-115 22517972-0 2012 Sequential metabolism of AMG 487, a novel CXCR3 antagonist, results in formation of quinone reactive metabolites that covalently modify CYP3A4 Cys239 and cause time-dependent inhibition of the enzyme. quinone 84-91 C-X-C motif chemokine receptor 3 Homo sapiens 42-47 22517972-0 2012 Sequential metabolism of AMG 487, a novel CXCR3 antagonist, results in formation of quinone reactive metabolites that covalently modify CYP3A4 Cys239 and cause time-dependent inhibition of the enzyme. quinone 84-91 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 136-142 22247006-6 2012 Additionally, increased gamma-H2A.X foci were observed following exposure to 25muM BQ for 30 min, 45 min, and 1 h, whereas this exposure did not significantly increase oxidative DNA damage. quinone 83-85 H2A.X variant histone Mus musculus 24-35 22205152-4 2012 This suggests that the presence of a modified quinone function is the structural factor excluding reductive activation of antitumour anthraquinone derivatives and analogues by CPR. quinone 46-53 cytochrome p450 oxidoreductase Homo sapiens 176-179 22226931-6 2012 Glutathione reductase was also inhibited by PQQ but in contrast to the effects of PQQ on TrxR1, its quinone reduction was not further stimulated. quinone 100-107 glutathione-disulfide reductase Homo sapiens 0-21 22317835-5 2012 After hybridized with miRNA-21 and reported DNA loading in gold nanoparticles (AuNPs) and biotin multi-functionalized bio bar codes, streptavidin-HRP was brought to the electrode through the specific interaction with biotin to catalyze the chemical oxidation of hydroquinone by H(2)O(2) to form benzoquinone. quinone 295-307 microRNA 21 Homo sapiens 22-30 22317835-6 2012 The electrochemical reduction signal of benzoquinone was utilized to monitor the miRNA-21 hybridization event. quinone 40-52 microRNA 21 Homo sapiens 81-89 21818552-4 2012 In addition to the well-documented action in reducing quinone compounds and preventing the formation of reactive oxygen species, NQO enzymes, especially NQO1 also possess other important biological activities. quinone 54-61 NAD(P)H quinone dehydrogenase 1 Homo sapiens 153-157 22240153-0 2012 Trimer hydroxylated quinone derived from apocynin targets cysteine residues of p47phox preventing the activation of human vascular NADPH oxidase. quinone 20-27 neutrophil cytosolic factor 1 Homo sapiens 79-86 22174077-1 2012 In this study, ten anthra-, nine naphtho-, and five benzoquinone compounds of natural origin and five synthetic naphthoquinones were assessed, using an enzymatic in vitro assay, for their potential to inhibit cyclooxygenase-1 and -2 (COX-1 and COX-2), the key enzymes of the arachidonic acid cascade. quinone 52-64 prostaglandin-endoperoxide synthase 1 Homo sapiens 209-232 22192820-0 2012 Ah receptor- and Nrf2-gene battery members: modulators of quinone-mediated oxidative and endoplasmic reticulum stress. quinone 58-65 aryl hydrocarbon receptor Homo sapiens 0-11 22192820-0 2012 Ah receptor- and Nrf2-gene battery members: modulators of quinone-mediated oxidative and endoplasmic reticulum stress. quinone 58-65 NFE2 like bZIP transcription factor 2 Homo sapiens 17-21 22192820-8 2012 In conclusion, tight coupling of Ah receptor- and Nrf2-regulated enzymes may prevent quinone-mediated oxidative and ER stress. quinone 85-92 aryl hydrocarbon receptor Homo sapiens 33-44 22192820-8 2012 In conclusion, tight coupling of Ah receptor- and Nrf2-regulated enzymes may prevent quinone-mediated oxidative and ER stress. quinone 85-92 NFE2 like bZIP transcription factor 2 Homo sapiens 50-54 22226931-5 2012 Interestingly, PQQ also stimulated redox cycling of TrxR1 with another quinone substrate, juglone, as much as 13-fold (k(cat)/K(m) increased from 105 min(-1) muM(-1) to 1331 min(-1) muM(-1) for juglone in the presence of 50 muM PQQ, mainly through a lowered apparent K(m) for juglone). quinone 71-78 thioredoxin reductase 1 Homo sapiens 52-57 21983691-1 2012 The Pdss2 gene product is needed for the isoprenylation of benzoquinone to generate coenzyme Q (CoQ). quinone 59-71 prenyl (solanesyl) diphosphate synthase, subunit 2 Mus musculus 4-9 21939388-2 2012 Homologues of VKORC1 (VKORH) exist throughout evolution, but in bacteria they appear to function in oxidative protein folding as well as quinone reduction. quinone 137-144 vitamin K epoxide reductase complex subunit 1 Homo sapiens 14-20 22257259-3 2012 The bond lengths and angles of the quinone moiety of the SQs( -) were in between the values reported for PCB quinones and hydroquinones, which is consistent with the distribution of the alpha highest occupied molecular orbital (alpha-HOMO). quinone 35-42 pyruvate carboxylase Homo sapiens 105-108 21384152-9 2012 Results from spectroscopy assays indicate that HT in the presence of peroxidases can undergo catechol-semiquinone-quinone redox cycling generating superoxide, which in a cellular context can activate the antioxidant system, e.g., MnSOD expression. quinone 106-113 superoxide dismutase 2 Homo sapiens 230-235 22005518-5 2012 In addition, this quinone was found to exhibit anticancer activity through the modulation of multiple molecular targets, including p53, p73, PTEN, STAT3, PPAR-gamma, activation of caspases and generation of ROS. quinone 18-25 transformation related protein 53, pseudogene Mus musculus 131-134 22005518-5 2012 In addition, this quinone was found to exhibit anticancer activity through the modulation of multiple molecular targets, including p53, p73, PTEN, STAT3, PPAR-gamma, activation of caspases and generation of ROS. quinone 18-25 transformation related protein 73 Mus musculus 136-139 22005518-5 2012 In addition, this quinone was found to exhibit anticancer activity through the modulation of multiple molecular targets, including p53, p73, PTEN, STAT3, PPAR-gamma, activation of caspases and generation of ROS. quinone 18-25 phosphatase and tensin homolog Mus musculus 141-145 22005518-5 2012 In addition, this quinone was found to exhibit anticancer activity through the modulation of multiple molecular targets, including p53, p73, PTEN, STAT3, PPAR-gamma, activation of caspases and generation of ROS. quinone 18-25 signal transducer and activator of transcription 3 Mus musculus 147-152 22005518-5 2012 In addition, this quinone was found to exhibit anticancer activity through the modulation of multiple molecular targets, including p53, p73, PTEN, STAT3, PPAR-gamma, activation of caspases and generation of ROS. quinone 18-25 peroxisome proliferator activated receptor gamma Mus musculus 154-164 22214931-1 2012 In the previous studies, we reported that carnosic acid (CA) protects cortical neurons by activating the Keap1/Nrf2 pathway, which activation is initiated by S-alkylation of the critical cysteine thiol of the Keap1 protein by the "electrophilic"quinone-type CA. quinone 245-252 kelch-like ECH-associated protein 1 Mus musculus 105-110 22214931-1 2012 In the previous studies, we reported that carnosic acid (CA) protects cortical neurons by activating the Keap1/Nrf2 pathway, which activation is initiated by S-alkylation of the critical cysteine thiol of the Keap1 protein by the "electrophilic"quinone-type CA. quinone 245-252 nuclear factor, erythroid derived 2, like 2 Mus musculus 111-115 22214931-1 2012 In the previous studies, we reported that carnosic acid (CA) protects cortical neurons by activating the Keap1/Nrf2 pathway, which activation is initiated by S-alkylation of the critical cysteine thiol of the Keap1 protein by the "electrophilic"quinone-type CA. quinone 245-252 kelch-like ECH-associated protein 1 Mus musculus 209-214 22147260-2 2012 We hypothesized that polymorphisms in oxidative stress (OS)-related genes, including estrogen-quinone metabolizing enzymes NQO2 and GSTM1-5, may influence disease progression and treatment response. quinone 94-101 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 123-127 22086148-6 2012 If the quinone is maintained in the reduced state, a task that in some cell types appears to be performed by dicoumarol-sensitive NAD(P)H:quinone oxidoreductase 1 [Haefeli et al. quinone 7-14 NAD(P)H quinone dehydrogenase 1 Homo sapiens 130-162 22121121-7 2012 In low moisture content aprotic solvents, vitamin K (a quinone) is reduced in two one-electron chemically reversible steps to form first a radical anion (semiquinone, at E(1)) and then at more negative potentials a dianion is formed (at E(2)). quinone 55-62 small nucleolar RNA, H/ACA box 73A Homo sapiens 170-174 22121121-7 2012 In low moisture content aprotic solvents, vitamin K (a quinone) is reduced in two one-electron chemically reversible steps to form first a radical anion (semiquinone, at E(1)) and then at more negative potentials a dianion is formed (at E(2)). quinone 55-62 cystatin 12, pseudogene Homo sapiens 237-241 22147260-2 2012 We hypothesized that polymorphisms in oxidative stress (OS)-related genes, including estrogen-quinone metabolizing enzymes NQO2 and GSTM1-5, may influence disease progression and treatment response. quinone 94-101 glutathione S-transferase mu 1 Homo sapiens 132-139 21914835-8 2011 It is of interest that one of the reactive metabolites with a quinone structure was predominantly conjugated with GSH by GSTM1. quinone 62-69 glutathione S-transferase mu 1 Homo sapiens 121-126 22224553-6 2012 Compounds that possess an orthodihydroxy or quinone structure can interact with cellular proteins in the Keap1/Nrf2/ARE pathway to activate the gene transcription of antioxidant enzymes. quinone 44-51 kelch like ECH associated protein 1 Homo sapiens 105-110 22224553-6 2012 Compounds that possess an orthodihydroxy or quinone structure can interact with cellular proteins in the Keap1/Nrf2/ARE pathway to activate the gene transcription of antioxidant enzymes. quinone 44-51 NFE2 like bZIP transcription factor 2 Homo sapiens 111-115 23167798-6 2012 Results show that quinone-derivatives that bear two electroactive groups (namely quinone and nitro) exhibit the highest inhibitory activity (Hsp90 cleavage and cell death). quinone 18-25 heat shock protein 90 alpha family class A member 1 Homo sapiens 141-146 23167798-6 2012 Results show that quinone-derivatives that bear two electroactive groups (namely quinone and nitro) exhibit the highest inhibitory activity (Hsp90 cleavage and cell death). quinone 81-88 heat shock protein 90 alpha family class A member 1 Homo sapiens 141-146 22032234-4 2011 Several small molecules inhibit APE1-mediated TF activation, including the quinone derivative E3330. quinone 75-82 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 32-36 21570853-0 2012 Evaluation of sulfatase-directed quinone methide traps for proteomics. quinone 33-40 arylsulfatase family member H Homo sapiens 14-23 21914835-9 2011 Thus, we demonstrated that the GST isoforms contributed differently to the GSH conjugation of individual reactive metabolites of troglitazone, and GSTM1 is the most important GST isoform in the GSH conjugation of a specific reactive metabolite produced from the cytotoxic, quinone-form metabolite of troglitazone. quinone 273-280 glutathione S-transferase mu 1 Homo sapiens 147-152 21827172-3 2011 GAPDH readily formed a covalent bond with 1,2-NQ through Cys152 at a low concentration (0.2 muM) in a cell-free system, but when human epithelial A549 cells were exposed to this quinone at 20 muM, only minimal binding was observed although extensive binding to numerous other cellular proteins occurred. quinone 178-185 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 0-5 21708945-2 2011 In each case, superoxide production had a similar bell-shaped relationship to the reduction state of cytochrome b(566), suggesting that superoxide production peaks at intermediate Q-reduction state because it comes from a semiquinone in the outer quinone-binding site in complex III (Q(o)). quinone 226-233 mitochondrially encoded cytochrome b Homo sapiens 101-113 24213135-2 2011 Hsp90a was downregulated using the post-transcriptional RNAi strategy (sihsp90a) and a post-translational inhibitor, the benzoquinone antibiotic 17-AAG. quinone 121-133 heat shock protein 90 alpha family class A member 2, pseudogene Homo sapiens 0-6 21645265-7 2011 In addition, the incubation of endothelial cells with benzoquinone (10 muM, 2 hr) impaired PECAM-1 expression and did not modify NF-kappaB nuclear activation. quinone 54-66 platelet and endothelial cell adhesion molecule 1 Rattus norvegicus 91-98 21927746-1 2011 A new quinone propionic acid-cloaked rhodamine fluorophore has its fluorescence revealed (de-cloaked) upon activation by human NAD(P)H:quinone oxidoreductase 1 (hNQO1), an upregulated enzyme in cancer cells and tumors. quinone 6-13 NAD(P)H quinone dehydrogenase 1 Homo sapiens 127-159 21927746-1 2011 A new quinone propionic acid-cloaked rhodamine fluorophore has its fluorescence revealed (de-cloaked) upon activation by human NAD(P)H:quinone oxidoreductase 1 (hNQO1), an upregulated enzyme in cancer cells and tumors. quinone 6-13 NAD(P)H quinone dehydrogenase 1 Homo sapiens 161-166 22109525-3 2011 The electrophilic metabolites N-acetyl-p-benzoquinoneimine and p-benzoquinone, but not acetaminophen itself, activate mouse and human TRPA1. quinone 55-69 transient receptor potential cation channel subfamily A member 1 Homo sapiens 166-171 22109525-6 2011 In the hot-plate test, intrathecal administration of N-acetyl-p-benzoquinoneimine, p-benzoquinone and the electrophilic TRPA1 activator cinnamaldehyde produced antinociception that was lost in Trpa1(-/-) mice. quinone 78-92 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 265-270 21850367-0 2011 Quinone methide tripterine, celastrol, induces apoptosis in human myeloma cells via NF-kappaB pathway. quinone 0-7 nuclear factor kappa B subunit 1 Homo sapiens 84-93 21803122-4 2011 The relation between QR2 and AD has not yet been determined; however, our results suggest that the increase in hippocampal QR2 might be a cause of AD or might promote the progression of AD by causing an increase in the toxic quinone levels and consequent loss of cognitive function. quinone 225-232 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 123-126 21664341-3 2011 To gain further insights into the mechanism of AIF, we investigated its interaction with a series of quinone oxidants, including a number of anticancer quinones. quinone 101-108 apoptosis inducing factor mitochondria associated 1 Homo sapiens 47-50 21664341-4 2011 Our data indicate that the NADH:quinone oxidoreduction catalyzed by AIF follows a "ping-pong" scheme, with the reductive half-reaction being rate-limiting and the FADH(-)-NAD(+) charge-transfer complex serving as an electron donor. quinone 32-39 apoptosis inducing factor mitochondria associated 1 Homo sapiens 68-71 21527774-0 2011 The frequency of 1,4-benzoquinone-lysine adducts in cytochrome c correlate with defects in apoptosome activation. quinone 17-33 cytochrome c, somatic Homo sapiens 52-64 21667279-3 2011 Inhibition of COX-2 leads to neuroprotection by preventing the formation of dopamine-quinone. quinone 85-92 prostaglandin-endoperoxide synthase 2 Homo sapiens 14-19 21569840-2 2011 NAD(P)H:quinone oxidoreductase-1 (NQO1) is an enzyme that catalyzes BaP-quinone detoxification. quinone 8-15 NAD(P)H dehydrogenase, quinone 1 Mus musculus 34-38 21538647-1 2011 Quinone reductase 2 (QR2) is one of two members comprising the mammalian quinone reductase family of enzymes responsible for performing FAD mediated reductions of quinone substrates. quinone 73-80 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 0-19 21538647-1 2011 Quinone reductase 2 (QR2) is one of two members comprising the mammalian quinone reductase family of enzymes responsible for performing FAD mediated reductions of quinone substrates. quinone 73-80 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 21-24 21527774-4 2011 Site-specific BQ-lysine adducts are found on residues in cytochrome c that are necessary for protein-protein interactions, and these adducts contribute to interferences in its ability to facilitate apoptosome formation. quinone 14-16 cytochrome c, somatic Homo sapiens 57-69 20846517-5 2011 Consequently, a two-step mechanism was proposed which involves oxidation of the diphenols to their corresponding quinone derivatives, followed by modification of specific cysteine residues of the sensor protein Keap1. quinone 113-120 kelch like ECH associated protein 1 Homo sapiens 211-216 21570285-2 2011 Most of these compounds show selective action favored to human cancer cell lines over normal cell lines, and compound 9 with bis-terminal benzoquinone functionality exhibits an IC(50)=0.40 muM against MCF7 cell lines. quinone 138-150 latexin Homo sapiens 189-192 21422192-6 2011 Metabolites of SCH 66712 detected by mass spectrometry indicate that the phenyl group on the imidazole ring of SCH 66712 is one site of oxidation by CYP2D6 and could lead to methylene quinone formation. quinone 184-191 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 149-155 21354283-0 2011 Characterization of estrogen quinone-derived protein adducts and their identification in human serum albumin derived from breast cancer patients and healthy controls. quinone 29-36 albumin Homo sapiens 101-108 21326294-2 2011 We show monobenzone to increase melanocyte and melanoma cell immunogenicity by forming quinone-haptens to the tyrosinase protein and by inducing the release of tyrosinase- and melanoma antigen recognized by T cells-1 (MART-1)-containing CD63+ exosomes following melanosome oxidative stress induction. quinone 87-94 tyrosinase Homo sapiens 110-120 21972526-1 2011 OBJECTIVE: To explore the effects of phosphatidylinositol 3-kinase/Serine-threonine kinase (PI3K/Akt) signal pathway on the proliferation of HL-60 cells exposed to benzoquinone (BQ). quinone 164-176 AKT serine/threonine kinase 1 Homo sapiens 97-100 21972526-1 2011 OBJECTIVE: To explore the effects of phosphatidylinositol 3-kinase/Serine-threonine kinase (PI3K/Akt) signal pathway on the proliferation of HL-60 cells exposed to benzoquinone (BQ). quinone 178-180 AKT serine/threonine kinase 1 Homo sapiens 97-100 21972526-10 2011 CONCLUSION: The PI3K/Akt signal pathway may play an important role in the proliferation of HL-60 cells exposed to BQ. quinone 114-116 AKT serine/threonine kinase 1 Homo sapiens 21-24 21621882-5 2011 The SAR analysis indicates that the location of nitrogen substituents on the quinone nucleus, the presence of methyl, phenyl, furyl and thienyl groups at the 6-position and the aromatization of the angular cycloaliphatic ring of the phenylamino-3,4-tetrahydrophenanthridine-1,7,10(2H)-trione pharmacophore play key roles in the antitumor activity. quinone 77-84 sarcosine dehydrogenase Homo sapiens 4-7 21259006-3 2011 The presumed ability of ArcB to sense redox changes in the cellular quinone pool and the strong decrease of psp induction in DeltaubiG or DeltaarcAB backgrounds suggest a link between the Psp response and the quinone pool. quinone 68-75 hypothetical protein Escherichia coli 24-28 21259006-3 2011 The presumed ability of ArcB to sense redox changes in the cellular quinone pool and the strong decrease of psp induction in DeltaubiG or DeltaarcAB backgrounds suggest a link between the Psp response and the quinone pool. quinone 209-216 hypothetical protein Escherichia coli 24-28 21354283-3 2011 Results from in vitro experiments confirmed that the production of estrogen quinone-derived adducts on serum Alb increased with increased concentration of estrogen quinones. quinone 76-83 albumin Homo sapiens 109-112 21384861-3 2011 In studies using 1,2-naphthoquinone (1,2-NQ) as a model quinone, we found that Keap1, the negative regulator of Nrf2, was readily arylated at its reactive thiols by 1,2-NQ. quinone 28-35 kelch-like ECH-associated protein 1 Mus musculus 79-84 21438561-2 2011 The present study provides rare insights into mechanistic differences between BQ and O(2) in their reactivity with a well-defined Pd-hydride complex, Pd(IMes)(2)(H)(O(2)CPh) (1). quinone 78-80 carboxypeptidase E Homo sapiens 169-172 21384861-3 2011 In studies using 1,2-naphthoquinone (1,2-NQ) as a model quinone, we found that Keap1, the negative regulator of Nrf2, was readily arylated at its reactive thiols by 1,2-NQ. quinone 28-35 nuclear factor, erythroid derived 2, like 2 Mus musculus 112-116 22132160-9 2011 Collectively, these results suggest that electrophilic p-quinone formed from 6-OHDA induces DJ-1 oxidation by decreasing intracellular GSH. quinone 55-64 Parkinsonism associated deglycase Homo sapiens 92-96 21177487-10 2011 We have shown the tendency of oxymetazoline to form p-quinone methide species via a bioactivation mechanism involving a CYP2C19-catalyzed two-electron oxidation. quinone 52-61 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 120-127 21059386-5 2011 Increased expression of well-known Nrf2-dependent proteins including NQO1, GCLM, GSS and HMOX was also observed in the HQ/BQ-treated cells. quinone 122-124 glutamate-cysteine ligase modifier subunit Homo sapiens 75-79 21059386-6 2011 Moreover, transient overexpression of Nrf2 conferred protection against HQ- and BQ-induced cell death, whereas knockdown of Nrf2 by small interfering RNA resulted in increased apoptosis. quinone 80-82 NFE2 like bZIP transcription factor 2 Homo sapiens 38-42 21059386-7 2011 We also found that the increased susceptibility of Nrf2-knockdown cells to HQ and BQ was associated with reduced glutathione levels and loss of inducibility of ARE-driven genes, suggesting that deficiency of Nrf2 impairs cellular redox capacity to counteract oxidative damage. quinone 82-84 NFE2 like bZIP transcription factor 2 Homo sapiens 51-55 21059386-7 2011 We also found that the increased susceptibility of Nrf2-knockdown cells to HQ and BQ was associated with reduced glutathione levels and loss of inducibility of ARE-driven genes, suggesting that deficiency of Nrf2 impairs cellular redox capacity to counteract oxidative damage. quinone 82-84 NFE2 like bZIP transcription factor 2 Homo sapiens 208-212 21059386-8 2011 Altogether, these results suggest that Nrf2-ARE pathway is essential for protection against HQ- and BQ-induced toxicity. quinone 100-102 NFE2 like bZIP transcription factor 2 Homo sapiens 39-43 21311751-9 2011 Deletion of the gene encoding the quinone-linked cytochrome CymA had a similar negative effect, which showed that electrons primarily flowed from outer membrane cytochromes into the quinone pool, and back to periplasmic FccA. quinone 34-41 cytochrome c Shewanella oneidensis MR-1 60-64 21311751-9 2011 Deletion of the gene encoding the quinone-linked cytochrome CymA had a similar negative effect, which showed that electrons primarily flowed from outer membrane cytochromes into the quinone pool, and back to periplasmic FccA. quinone 182-189 cytochrome c Shewanella oneidensis MR-1 60-64 21035322-3 2011 The biosensor also works well in the second generation biosensing mode with p-benzoquinone (BQ) or ferrocene monocarboxylic acid (Fc) as an artificial mediator, with greatly broadened linear detection ranges (2.0 muM-48.0 mM for BQ and 2.0 muM-16.0 mM for Fc) and up to mA cm(-2)-scale glucose-saturated current density. quinone 76-90 latexin Homo sapiens 213-216 21035322-3 2011 The biosensor also works well in the second generation biosensing mode with p-benzoquinone (BQ) or ferrocene monocarboxylic acid (Fc) as an artificial mediator, with greatly broadened linear detection ranges (2.0 muM-48.0 mM for BQ and 2.0 muM-16.0 mM for Fc) and up to mA cm(-2)-scale glucose-saturated current density. quinone 76-90 latexin Homo sapiens 240-243 21035322-3 2011 The biosensor also works well in the second generation biosensing mode with p-benzoquinone (BQ) or ferrocene monocarboxylic acid (Fc) as an artificial mediator, with greatly broadened linear detection ranges (2.0 muM-48.0 mM for BQ and 2.0 muM-16.0 mM for Fc) and up to mA cm(-2)-scale glucose-saturated current density. quinone 92-94 latexin Homo sapiens 213-216 21035322-3 2011 The biosensor also works well in the second generation biosensing mode with p-benzoquinone (BQ) or ferrocene monocarboxylic acid (Fc) as an artificial mediator, with greatly broadened linear detection ranges (2.0 muM-48.0 mM for BQ and 2.0 muM-16.0 mM for Fc) and up to mA cm(-2)-scale glucose-saturated current density. quinone 92-94 latexin Homo sapiens 240-243 21772844-8 2011 Vitamin C and/or antibody to p-BQ prevents AECS/p-BQ-induced proliferation of lung cells apparently by inactivating p-BQ and thereby preventing activation of EGFR and the downstream signaling molecules. quinone 48-52 epidermal growth factor receptor Homo sapiens 158-162 22132160-4 2011 However, when catalase, which is an hydrogen peroxide (H(2)O(2))-removing enzyme, was added during the treatment, it failed to prevent the oxidation induced by 6-OHDA, suggesting that electrophilic p-quinone formed from 6-OHDA, but not H(2)O(2), was responsible for the DJ-1 oxidation. quinone 198-207 catalase Homo sapiens 14-22 22132160-5 2011 Benzoquinone, another electrophilic p-quinone, also induced DJ-1 oxidation. quinone 0-12 Parkinsonism associated deglycase Homo sapiens 60-64 22132160-5 2011 Benzoquinone, another electrophilic p-quinone, also induced DJ-1 oxidation. quinone 36-45 Parkinsonism associated deglycase Homo sapiens 60-64 20961044-7 2011 In comparison with common major metabolites, PAH transformations produced various types of potentially toxic intermediates, including epoxide, quinone, phenols, aldehydes, and phthalates. quinone 143-150 phenylalanine hydroxylase Homo sapiens 45-48 21240422-3 2011 The principle of catechol estimation was based on the reduction of biocatalytically liberated quinone species at +0.2 V versus Ag/AgCl (3 M KCl), with good stability, sensitivity, and featuring a low detection limit (about 0.002 muM) and wide linear range (0.005 muM-120 muM). quinone 94-101 latexin Homo sapiens 229-232 21240422-3 2011 The principle of catechol estimation was based on the reduction of biocatalytically liberated quinone species at +0.2 V versus Ag/AgCl (3 M KCl), with good stability, sensitivity, and featuring a low detection limit (about 0.002 muM) and wide linear range (0.005 muM-120 muM). quinone 94-101 latexin Homo sapiens 263-266 21240422-3 2011 The principle of catechol estimation was based on the reduction of biocatalytically liberated quinone species at +0.2 V versus Ag/AgCl (3 M KCl), with good stability, sensitivity, and featuring a low detection limit (about 0.002 muM) and wide linear range (0.005 muM-120 muM). quinone 94-101 latexin Homo sapiens 263-266 21172426-5 2011 TrxR2 displayed strikingly lower activity with dithionitrobenzoic acid (DTNB), lipoamide, and the quinone substrate juglone compared to TrxR1, and TrxR2 could not reduce lipoic acid. quinone 98-105 thioredoxin reductase 2 Homo sapiens 0-5 21156818-2 2011 The formation of 17AAGH2 by NQO1 results in a molecule that binds with greater affinity to Hsp90 compared with the parent quinone. quinone 122-129 NAD(P)H quinone dehydrogenase 1 Homo sapiens 28-32 21156818-2 2011 The formation of 17AAGH2 by NQO1 results in a molecule that binds with greater affinity to Hsp90 compared with the parent quinone. quinone 122-129 heat shock protein 90 alpha family class A member 1 Homo sapiens 91-96 21059386-0 2011 Essential role of Nrf2 in protection against hydroquinone- and benzoquinone-induced cytotoxicity. quinone 63-75 NFE2 like bZIP transcription factor 2 Homo sapiens 18-22 21059386-5 2011 Increased expression of well-known Nrf2-dependent proteins including NQO1, GCLM, GSS and HMOX was also observed in the HQ/BQ-treated cells. quinone 122-124 NFE2 like bZIP transcription factor 2 Homo sapiens 35-39 21059386-5 2011 Increased expression of well-known Nrf2-dependent proteins including NQO1, GCLM, GSS and HMOX was also observed in the HQ/BQ-treated cells. quinone 122-124 NAD(P)H quinone dehydrogenase 1 Homo sapiens 69-73 21772844-8 2011 Vitamin C and/or antibody to p-BQ prevents AECS/p-BQ-induced proliferation of lung cells apparently by inactivating p-BQ and thereby preventing activation of EGFR and the downstream signaling molecules. quinone 29-33 epidermal growth factor receptor Homo sapiens 158-162 20951799-8 2010 Using mass spectrometry, we have demonstrated the formation of EGCG-Trx1 (Cys(32)) and EGCG-TrxR (Cys/Sec) conjugates, confirming that EGCG quinone specifically conjugates with active-site Cys(32) in Trx or C-terminal Cys/Selenocysteine (Sec) couple in TrxR under conditions where Trx/TrxR are reduced. quinone 140-147 peroxiredoxin 5 Homo sapiens 253-257 21619792-0 2011 [mRNA expression and methylation status of p15 promoter in mouse bone marrow cells exposed to 1,4-benzoquinone]. quinone 94-110 cyclin dependent kinase inhibitor 2B Mus musculus 43-46 21619792-1 2011 OBJECTIVE: To detect the expression and the CpG island methylation status of tumor suppressor gene p15 after exposure to 1,4-benzoquinone (1,4-BQ) in primary cultivated C57BL/6J mouse bone marrow cells in vitro. quinone 121-137 cyclin dependent kinase inhibitor 2B Mus musculus 99-102 21619792-1 2011 OBJECTIVE: To detect the expression and the CpG island methylation status of tumor suppressor gene p15 after exposure to 1,4-benzoquinone (1,4-BQ) in primary cultivated C57BL/6J mouse bone marrow cells in vitro. quinone 139-145 cyclin dependent kinase inhibitor 2B Mus musculus 99-102 21619792-9 2011 CONCLUSION: mRNA expression of p15 gene decreases after exposure to 1,4-BQ, but the CpG islands methylation status in promoter is not affected, suggesting that methylation does not participate in 1,4-BQ-mediated p15 gene expression decrease, other effect mechanisms still need to be investigated. quinone 68-74 cyclin dependent kinase inhibitor 2B Mus musculus 31-34 20951799-8 2010 Using mass spectrometry, we have demonstrated the formation of EGCG-Trx1 (Cys(32)) and EGCG-TrxR (Cys/Sec) conjugates, confirming that EGCG quinone specifically conjugates with active-site Cys(32) in Trx or C-terminal Cys/Selenocysteine (Sec) couple in TrxR under conditions where Trx/TrxR are reduced. quinone 140-147 peroxiredoxin 5 Homo sapiens 253-257 20558128-10 2010 We hypothesize that an electrophilic quinone formed as a consequence of oxidation of piceatannol bearing the catechol moiety may bind directly to Kelch-like ECH-associated protein 1 (Keap1), an inhibitory protein that sequesters Nrf2 in the cytoplasm. quinone 37-44 NFE2 like bZIP transcription factor 2 Homo sapiens 229-233 20851755-8 2010 We then checked quinone-bound proteins as quinones produced by COX-2 bind to intracellular proteins. quinone 16-23 prostaglandin-endoperoxide synthase 2 Homo sapiens 63-68 20851755-9 2010 Paraquat obviously forms quinone-bound proteins, in particular, quinone-bound DJ-1 and this formation is attenuated by meloxicam. quinone 25-32 Parkinsonism associated deglycase Homo sapiens 78-82 20851755-9 2010 Paraquat obviously forms quinone-bound proteins, in particular, quinone-bound DJ-1 and this formation is attenuated by meloxicam. quinone 64-71 Parkinsonism associated deglycase Homo sapiens 78-82 20863074-3 2010 Bromination of 1 with NBS/DMF gave its quinone form 2 via an unusual pathway. quinone 39-46 nibrin Homo sapiens 22-25 20861374-3 2010 QR2 is a cytosolic flavoprotein that catalyzes the reduction of its substrate and enhances the production of damaging activated quinone and ROS. quinone 128-135 N-ribosyldihydronicotinamide:quinone reductase 2 Rattus norvegicus 0-3 20558128-10 2010 We hypothesize that an electrophilic quinone formed as a consequence of oxidation of piceatannol bearing the catechol moiety may bind directly to Kelch-like ECH-associated protein 1 (Keap1), an inhibitory protein that sequesters Nrf2 in the cytoplasm. quinone 37-44 kelch like ECH associated protein 1 Homo sapiens 146-181 20558128-10 2010 We hypothesize that an electrophilic quinone formed as a consequence of oxidation of piceatannol bearing the catechol moiety may bind directly to Kelch-like ECH-associated protein 1 (Keap1), an inhibitory protein that sequesters Nrf2 in the cytoplasm. quinone 37-44 kelch like ECH associated protein 1 Homo sapiens 183-188 21235518-1 2011 Previously, we reported that vitamin K(3), which consists of a quinone component, inhibits the activity of human DNA polymerase gamma (pol gamma). quinone 63-70 polymerase (DNA directed), gamma Mus musculus 135-144 21235518-3 2011 BQ and NQ potently inhibited the activity of all the pol species: pols alpha, beta, gamma, delta, epsilon and lambda, and NQ was a stronger pol inhibitor than BQ. quinone 0-2 polymerase (DNA directed), beta Mus musculus 66-124 21235518-6 2011 In a cell culture system using mouse macrophages, NQ displayed the strongest suppression in the production of tumor necrosis factor (TNF)-alpha induced by lipopolysaccharide (LPS) among the quinone derivatives tested. quinone 190-197 tumor necrosis factor Mus musculus 110-143 20513347-1 2010 The two spatially distant quinone-binding sites of the ubihydroquinone: cytochrome c oxidoreductase (cyt bc(1)) complex have been shown to influence one another in some fashion. quinone 26-33 cytochrome c, somatic Homo sapiens 72-84 20513347-1 2010 The two spatially distant quinone-binding sites of the ubihydroquinone: cytochrome c oxidoreductase (cyt bc(1)) complex have been shown to influence one another in some fashion. quinone 26-33 thioredoxin reductase 1 Homo sapiens 85-99 21139339-2 2010 However, little information on whether this quinone can affect inducible NOS (iNOS) is available. quinone 44-51 nitric oxide synthase 2, inducible Mus musculus 78-82 20685355-13 2010 Our findings suggest that the mechanisms of CAPE toxicity in SK-MEL-28 melanoma cells mediated by tyrosinase bioactivation of CAPE included quinone formation, ROS formation, intracellular GSH depletion and induced mitochondrial toxicity. quinone 140-147 tyrosinase Homo sapiens 98-108 20600898-2 2010 Earlier we have reported that tyrosinase-catalyzed oxidation of dehydro NADA produces a reactive quinone methide imine amide that forms adducts and cross-links through its side chain, thereby accounting for sclerotization reactions. quinone 97-104 tyrosinase Homo sapiens 30-40 20540524-6 2010 The potency of 4-OHEN toward classical ERalpha mediated activity was unexpected given the reported rapid autoxidation and trapping of the resultant quinone by GSH. quinone 148-155 estrogen receptor 1 Equus caballus 39-46 20584749-7 2010 We speculate that an electrophilic quinone formed as a consequence of oxidation of PIC bearing the catechol moiety may directly interact with critical cysteine thiols of IKKbeta, thereby inhibiting its catalytic activity. quinone 35-42 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 170-177 20382756-1 2010 We have previously identified that the predominant metabolic pathway for tanshinone IIa (TSA) in rat is the NAD(P)H:quinone oxidoreductase 1 (NQO1)-mediated quinone reduction and subsequent glucuronidation. quinone 116-123 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 142-146 20690752-0 2010 Para-quinone-containing bis(pyrazol-1-yl)methane ligands: coordination behavior toward Co(II) and a C-H activation reaction with Ce(IV). quinone 0-12 mitochondrially encoded cytochrome c oxidase II Homo sapiens 87-93 20690752-4 2010 Contrary to that, the methyl derivative L3(Me2) is transformed into the ortho-benzoquinone species L5(Me2), which still contains one methoxy substituent while one oxygen atom has been newly introduced. quinone 78-90 malic enzyme 2 Homo sapiens 43-46 20690752-4 2010 Contrary to that, the methyl derivative L3(Me2) is transformed into the ortho-benzoquinone species L5(Me2), which still contains one methoxy substituent while one oxygen atom has been newly introduced. quinone 78-90 malic enzyme 2 Homo sapiens 102-105 20518072-3 2010 ENOX2 has been proposed as the cellular target for various quinone site inhibitors that demonstrate anticancer activity such as the green tea constituent epigallocatechin-3-gallate (EGCg) and the isoflavone phenoxodiol (PXD). quinone 59-66 ecto-NOX disulfide-thiol exchanger 2 Homo sapiens 0-5 20481436-7 2010 The latter quinone units quench the QDs via an electron transfer route, leading to the optical detection of the ALP activity. quinone 11-18 alkaline phosphatase, placental Homo sapiens 112-115 20345183-8 2010 TrxR also catalyzes quinone redox cycling, a process that generates reactive oxygen species. quinone 20-27 peroxiredoxin 5 Homo sapiens 0-4 21073132-1 2010 NAD(P)H:quinone acceptor oxidoreductase (NQO) 1 polymorphism is associated with various hematological malignancies, especially infant leukemia or therapy-related leukemias, which involve the rearrangement of mixed lineage leukemia (MLL) gene. quinone 8-15 lysine methyltransferase 2A Homo sapiens 232-235 20499891-0 2010 1,4-Benzoquinone (PBQ) induced toxicity in lung epithelial cells is mediated by the disruption of the microtubule network and activation of caspase-3. quinone 0-16 caspase 3 Homo sapiens 140-149 20507089-9 2010 Characterization of the GSH conjugate structures allowed insight(s) into the bioactivation pathway, which involved CYP3A4-mediated phenol ring oxidation to the catechol, followed by further oxidation to the electrophilic ortho-quinone species. quinone 227-234 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 115-121 20059739-6 2010 Upon restriction of AOX pathway using salicylhydroxamic acid (SHAM), the observed decrease in NaHCO(3)-dependent O(2) evolution or p-benzoquinone (BQ)-dependent O(2) evolution [indicator of photosystem II (PSII) activity] and the increase in total cellular levels of pyruvate and malate were further aggravated/promoted under HL. quinone 131-145 acyl-CoA oxidase 1 Homo sapiens 20-23 20144727-1 2010 The benzoquinone derivative embelin is a multifunctional drug that not only induces apoptosis by inhibiting XIAP, the X chromosome-linked inhibitor of apoptosis protein, but also blocks nuclear factor-kappaB signaling pathways, thereby leading to down-regulation of a variety of gene products involved in tumor cell survival, proliferation, invasion, angiogenesis, and inflammation. quinone 4-16 X-linked inhibitor of apoptosis Homo sapiens 108-112 20059739-6 2010 Upon restriction of AOX pathway using salicylhydroxamic acid (SHAM), the observed decrease in NaHCO(3)-dependent O(2) evolution or p-benzoquinone (BQ)-dependent O(2) evolution [indicator of photosystem II (PSII) activity] and the increase in total cellular levels of pyruvate and malate were further aggravated/promoted under HL. quinone 147-149 acyl-CoA oxidase 1 Homo sapiens 20-23 20192260-3 2010 To identify the ubiquinone (UQ) binding site in Ndi1, we conducted photoaffinity labeling using a photoreactive biotinylated UQ mimic (compound 2) synthesized following a concept of the least possible modification of the substituents on the quinone ring. quinone 19-26 NADH-ubiquinone reductase (H(+)-translocating) NDI1 Saccharomyces cerevisiae S288C 48-52 20109102-5 2010 6-OHDA could induce the elevation of Grp58 and CHOP in the presence of catalase, a hydrogen peroxide-removing enzyme, suggesting that the elevation of Grp58 and CHOP are induced by both hydrogen peroxide and p-quinone generated by 6-OHDA. quinone 208-217 protein disulfide isomerase family A, member 3 Rattus norvegicus 37-42 20109102-5 2010 6-OHDA could induce the elevation of Grp58 and CHOP in the presence of catalase, a hydrogen peroxide-removing enzyme, suggesting that the elevation of Grp58 and CHOP are induced by both hydrogen peroxide and p-quinone generated by 6-OHDA. quinone 208-217 DNA-damage inducible transcript 3 Rattus norvegicus 47-51 20109102-5 2010 6-OHDA could induce the elevation of Grp58 and CHOP in the presence of catalase, a hydrogen peroxide-removing enzyme, suggesting that the elevation of Grp58 and CHOP are induced by both hydrogen peroxide and p-quinone generated by 6-OHDA. quinone 208-217 catalase Rattus norvegicus 71-79 20109102-5 2010 6-OHDA could induce the elevation of Grp58 and CHOP in the presence of catalase, a hydrogen peroxide-removing enzyme, suggesting that the elevation of Grp58 and CHOP are induced by both hydrogen peroxide and p-quinone generated by 6-OHDA. quinone 208-217 protein disulfide isomerase family A, member 3 Rattus norvegicus 151-156 20109102-5 2010 6-OHDA could induce the elevation of Grp58 and CHOP in the presence of catalase, a hydrogen peroxide-removing enzyme, suggesting that the elevation of Grp58 and CHOP are induced by both hydrogen peroxide and p-quinone generated by 6-OHDA. quinone 208-217 DNA-damage inducible transcript 3 Rattus norvegicus 161-165 20480001-2 2010 Although such quinone derivatives are usually produced via the autoxidation of catecholamines, tyrosinase, which is a key enzyme in melanin biosynthesis via the production of DOPA and subsequent molecules, can potentially accelerate the induction of catecholamine quinone derivatives by its oxidase activity. quinone 14-21 tyrosinase Homo sapiens 95-105 20480001-2 2010 Although such quinone derivatives are usually produced via the autoxidation of catecholamines, tyrosinase, which is a key enzyme in melanin biosynthesis via the production of DOPA and subsequent molecules, can potentially accelerate the induction of catecholamine quinone derivatives by its oxidase activity. quinone 264-271 tyrosinase Homo sapiens 95-105 19944085-1 2010 The aim of this study was to identify a phenolic prodrug compound that is minimally metabolized by rat liver microsomes, but yet could form quinone reactive intermediates in melanoma cells as a result of its bioactivation by tyrosinase. quinone 140-147 tyrosinase Rattus norvegicus 225-235 20074573-5 2010 This is the first finding that ND2 was photo-crosslinked with a potent complex I inhibitor, suggesting its involvement in the inhibitor/quinone-binding. quinone 136-143 NADH dehydrogenase subunit 2 Bos taurus 31-34 19926469-1 2010 One-pot chemical oxidation of 1,6-hexanedithiol (HDT) in its aqueous suspension containing glucose oxidase (GOx) and Fe(3)O(4)-Au nanocomposites by 1,4-benzoquinone yields novel Fe(3)O(4)-Au-poly(HDT) (PHDT)-GOx magnetic polymeric bionanocomposites (MPBNCs) with GOx immobilized at high load and high activity. quinone 148-164 hydroxyacid oxidase 1 Homo sapiens 91-106 19926469-1 2010 One-pot chemical oxidation of 1,6-hexanedithiol (HDT) in its aqueous suspension containing glucose oxidase (GOx) and Fe(3)O(4)-Au nanocomposites by 1,4-benzoquinone yields novel Fe(3)O(4)-Au-poly(HDT) (PHDT)-GOx magnetic polymeric bionanocomposites (MPBNCs) with GOx immobilized at high load and high activity. quinone 148-164 hydroxyacid oxidase 1 Homo sapiens 108-111 19926469-1 2010 One-pot chemical oxidation of 1,6-hexanedithiol (HDT) in its aqueous suspension containing glucose oxidase (GOx) and Fe(3)O(4)-Au nanocomposites by 1,4-benzoquinone yields novel Fe(3)O(4)-Au-poly(HDT) (PHDT)-GOx magnetic polymeric bionanocomposites (MPBNCs) with GOx immobilized at high load and high activity. quinone 148-164 hydroxyacid oxidase 1 Homo sapiens 208-211 19926469-1 2010 One-pot chemical oxidation of 1,6-hexanedithiol (HDT) in its aqueous suspension containing glucose oxidase (GOx) and Fe(3)O(4)-Au nanocomposites by 1,4-benzoquinone yields novel Fe(3)O(4)-Au-poly(HDT) (PHDT)-GOx magnetic polymeric bionanocomposites (MPBNCs) with GOx immobilized at high load and high activity. quinone 148-164 hydroxyacid oxidase 1 Homo sapiens 208-211 19932748-0 2010 Evidence for NAD(P)H:quinone oxidoreductase 1 (NQO1)-mediated quinone-dependent redox cycling via plasma membrane electron transport: A sensitive cellular assay for NQO1. quinone 21-28 NAD(P)H quinone dehydrogenase 1 Canis lupus familiaris 47-51 20067291-0 2010 Design and synthesis of novel quinone inhibitors targeted to the redox function of apurinic/apyrimidinic endonuclease 1/redox enhancing factor-1 (Ape1/ref-1). quinone 30-37 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 146-150 20067291-0 2010 Design and synthesis of novel quinone inhibitors targeted to the redox function of apurinic/apyrimidinic endonuclease 1/redox enhancing factor-1 (Ape1/ref-1). quinone 30-37 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 151-156 20067291-5 2010 Benzoquinone and naphthoquinone analogues of the Ape1-inhibitor E3330 were designed and synthesized to explore structural effects on redox function and inhibition of cell growth. quinone 0-12 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 49-53 19932748-0 2010 Evidence for NAD(P)H:quinone oxidoreductase 1 (NQO1)-mediated quinone-dependent redox cycling via plasma membrane electron transport: A sensitive cellular assay for NQO1. quinone 21-28 NAD(P)H quinone dehydrogenase 1 Canis lupus familiaris 165-169 19908836-2 2010 Optimization of a screening hit using structure-based design and modification of log D and chemical structural features led to the identification of a class of orally bioavailable non-quinone-containing Hsp90 inhibitors. quinone 184-191 heat shock protein 90 alpha family class A member 1 Homo sapiens 203-208 20110994-4 2010 The catalytic core of VKOR is a four transmembrane helix bundle that surrounds a quinone, connected through an additional transmembrane segment with the periplasmic thioredoxin-like domain. quinone 81-88 vitamin K epoxide reductase complex subunit 1 Homo sapiens 22-26 20110994-5 2010 We propose a pathway for how VKOR uses electrons from cysteines of newly synthesized proteins to reduce a quinone, a mechanism confirmed by in vitro reconstitution of vitamin K-dependent disulphide bridge formation. quinone 106-113 vitamin K epoxide reductase complex subunit 1 Homo sapiens 29-33 19928783-0 2009 Spin-carrying benzoquinone derivatives. quinone 14-26 spindlin 1 Homo sapiens 0-4 20391128-2 2010 Quinone oxidoreductase 1 (NQO1) is an important detoxification enzyme involved in the catabolism of 1,4-benzoquinone (1,4-BQ), a benzene metabolite believed to be associated with bone-marrow toxicity and leukemia. quinone 100-116 NAD(P)H quinone dehydrogenase 1 Homo sapiens 26-30 20391128-2 2010 Quinone oxidoreductase 1 (NQO1) is an important detoxification enzyme involved in the catabolism of 1,4-benzoquinone (1,4-BQ), a benzene metabolite believed to be associated with bone-marrow toxicity and leukemia. quinone 118-124 NAD(P)H quinone dehydrogenase 1 Homo sapiens 26-30 19952498-0 2009 Catechol estrogens mediated activation of Nrf2 through covalent modification of its quinone metabolite to Keap1. quinone 84-91 nuclear factor, erythroid derived 2, like 2 Mus musculus 42-46 19828014-9 2009 This toxic quinone was produced by stimulated neutrophils in a reaction that required myeloperoxidase. quinone 11-18 myeloperoxidase Homo sapiens 86-101 19719482-2 2009 The AOX is located in the inner mitochondrial membrane and branches from the cytochrome pathway at the level of the quinone pool. quinone 116-123 acyl-CoA oxidase 1 Homo sapiens 4-7 19719482-6 2009 In this paper, we provide an overview of general features and current knowledge available about the AOX with emphasis on structure, the active site and quinone-binding site. quinone 152-159 acyl-CoA oxidase 1 Homo sapiens 100-103 19952119-3 2009 In cells, the free base of IPI-504 hydroquinone exists in a dynamic redox equilibrium with its corresponding quinone (17-AAG); the hydroquinone form binding 50 times more tightly to Hsp90. quinone 40-47 N-methylpurine DNA glycosylase Homo sapiens 121-124 19952119-3 2009 In cells, the free base of IPI-504 hydroquinone exists in a dynamic redox equilibrium with its corresponding quinone (17-AAG); the hydroquinone form binding 50 times more tightly to Hsp90. quinone 40-47 heat shock protein 90 alpha family class A member 1 Homo sapiens 182-187 19952119-5 2009 Here, we have devised a method to directly measure the intracellular ratio of hydroquinone to quinone (HQ/Q) and have applied this measurement to correlate NQO1 enzyme abundance with HQ/Q ratio and cellular activity of IPI-504 in 30 cancer cell lines. quinone 83-90 NAD(P)H quinone dehydrogenase 1 Homo sapiens 156-160 19493305-2 2009 The AOX is located at the inner surface of the inner mitochondrial membrane, being activated by over-reduction of the quinone pool and accumulation of keto-acids such as pyruvate. quinone 118-125 acyl-CoA oxidase 1 Homo sapiens 4-7 19952498-0 2009 Catechol estrogens mediated activation of Nrf2 through covalent modification of its quinone metabolite to Keap1. quinone 84-91 kelch-like ECH-associated protein 1 Mus musculus 106-111 19682488-2 2009 Exposure to the redox-cycling quinone juglone upon exit from dauer diapause results in defective egg-laying (Egl phenotype) in the pcm-1 mutants only. quinone 30-37 Protein-L-isoaspartate O-methyltransferase Caenorhabditis elegans 131-136 20030937-0 2009 [Effect of 1,4-benzoquinone on growth of hematopoietic myeloid progenitor cells with IFN-gamma different genotypes]. quinone 11-27 interferon gamma Homo sapiens 85-94 20030937-1 2009 This study was aimed to investigate the effect of 1,4-benzoquinone (1,4-BQ) on growth of myeloid progenitor cells with IFN-gamma different genotypes and to compare its differences. quinone 50-66 interferon gamma Homo sapiens 119-128 20030937-1 2009 This study was aimed to investigate the effect of 1,4-benzoquinone (1,4-BQ) on growth of myeloid progenitor cells with IFN-gamma different genotypes and to compare its differences. quinone 68-74 interferon gamma Homo sapiens 119-128 19688691-1 2009 NAD(P)H: quinone oxidoreductase 1 (NQO1), a cytosolic enzyme which catalyzes the two-electron reduction of quinone compounds, has been suggested to prevent the generation of semiquinone free radicals and reactive oxygen species, thus protecting cells from oxidative damage. quinone 9-16 NAD(P)H quinone dehydrogenase 1 Homo sapiens 35-39 19699263-0 2009 Protective effect of pyrroloquinoline quinone against Abeta-induced neurotoxicity in human neuroblastoma SH-SY5Y cells. quinone 38-45 amyloid beta precursor protein Homo sapiens 54-59 19263098-4 2009 The compounds studied displays a higher affinity in trypanothione reductase (TR) than glutathione reductase (GR), since only two out of 28 quinone compounds presented more favorable docking energy in the site of human enzyme. quinone 139-146 glutathione-disulfide reductase Homo sapiens 86-107 19263098-4 2009 The compounds studied displays a higher affinity in trypanothione reductase (TR) than glutathione reductase (GR), since only two out of 28 quinone compounds presented more favorable docking energy in the site of human enzyme. quinone 139-146 glutathione-disulfide reductase Homo sapiens 109-111 19628038-9 2009 Cells expressing polymorphic NQO1 treated with E(2)-3,4-Q with or without added Ro41-0960, showed lower ability to reduce the quinone ( approximately 50% lower levels of the free catechols and approximately 3-fold lower levels of methylated catechols) compared to the wild-type enzyme. quinone 126-133 NAD(P)H quinone dehydrogenase 1 Homo sapiens 29-33 19618916-9 2009 This curious situation is consistent with the structure of Lot6p, which has a crease we propose to be the binding site for pyridine nucleotides and a space, but no obvious catalytic residues, near the flavin allowing the quinone to react. quinone 221-228 flavin-dependent quinone reductase Saccharomyces cerevisiae S288C 59-64 19618916-10 2009 The decidedly suboptimized catalytic cycle suggests that selective pressures other than maximizing quinone consumption shaped the evolution of Lot6p. quinone 99-106 flavin-dependent quinone reductase Saccharomyces cerevisiae S288C 143-148 19634918-2 2009 The noncovalent binding of the inhibitory flavonoids to alpha-synuclein and the covalent modification by the flavonoid quinone led to the restriction of the conformational changes in this natively unfolded protein and to the stabilization of soluble flavonoid-modified species of alpha-synuclein (monomers and oligomers). quinone 119-126 synuclein alpha Homo sapiens 280-295 19386398-4 2009 The identification of the main peak formed after the tyrosinase reaction was attempted by LC-MS and the conversion of prodrug to the quinone was confirmed. quinone 133-140 tyrosinase Homo sapiens 53-63 19642985-7 2009 RESULT AND CONCLUSION: This study reports a new non-quinone DMAQ B1 derivative, a hydroxyfuroic acid compound (D-410639), which is 128 fold less cytotoxic as DMAQ B1 and as potent as compound 2, a DMAQ B1 synthetic derivative from Merck, at activating human insulin receptor. quinone 52-59 insulin receptor Homo sapiens 258-274 19212761-8 2009 If an oxidized benzene metabolite such as p-BQ was actually the precursor for the ultimate carcinogenic benzene metabolite and further activation proceeds via MPO mediated reactions, it should be possible to activate p-BQ to a genotoxic compound in vitro. quinone 42-46 myeloperoxidase Homo sapiens 159-162 19212761-8 2009 If an oxidized benzene metabolite such as p-BQ was actually the precursor for the ultimate carcinogenic benzene metabolite and further activation proceeds via MPO mediated reactions, it should be possible to activate p-BQ to a genotoxic compound in vitro. quinone 217-221 myeloperoxidase Homo sapiens 159-162 19285950-6 2009 Knockdown of PsbP modified both the donor and acceptor sides of PSII; In addition to the lower water-splitting activity, the primary quinone Q(A) in PSII was significantly reduced even when the photosystem I reaction center (P700) was noticeably oxidized, and thermoluminescence studies suggested the stabilization of the charged pair, S(2)/Q(A)(-). quinone 133-140 oxygen-evolving enhancer protein 2-2, chloroplastic Nicotiana tabacum 13-17 19364830-8 2009 In addition, the quinone methide reactive metabolite was a mechanism-based inactivator of CYP3A4, with inactivation parameters K(I) = 31 microM and k(inact) = 0.029 min(-1), respectively. quinone 17-24 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 90-96 19530895-4 2009 Thirteen (52%) of the Cdc25B inhibitor hits were quinone-based structures. quinone 49-56 cell division cycle 25B Homo sapiens 22-28 19441108-10 2009 Non-quinone Hsp90 inhibitors exhibit tumor-specific accumulation and exert potent antineoplastic activity without causing significant hepatotoxicity. quinone 4-11 heat shock protein 90 alpha family class A member 1 Homo sapiens 12-17 19374955-1 2009 Plumbagin (5-hydroxy-2-methyl-1, 4-naphthoquinone), a quinone isolated from the roots of Plumbago zeylanica was recently reported to suppress the activation of NF-kappaB in tumor cells. quinone 42-49 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 160-169 19415898-1 2009 During the operation of cytochrome bc(1), a key enzyme of biological energy conversion, the iron-sulfur head domain of one of the subunits of the catalytic core undergoes a large-scale movement from the catalytic quinone oxidation Q(o) site to cytochrome c(1). quinone 213-220 cytochrome c, somatic Homo sapiens 244-256 19349281-7 2009 Tyr-59 in zeta-crystallin (Tyr-51 in PIG3) was suggested to participate in the catalysis of quinone reduction. quinone 92-99 crystallin zeta Sus scrofa 10-25 19497415-8 2009 Similar protective effects of quinone derivatives were seen in HuH-7 and PC12 cells incubated with distinct apoptotic stimuli, such as camptothecin, TGF-beta1, or rotenone. quinone 30-37 MIR7-3 host gene Homo sapiens 63-68 19497415-8 2009 Similar protective effects of quinone derivatives were seen in HuH-7 and PC12 cells incubated with distinct apoptotic stimuli, such as camptothecin, TGF-beta1, or rotenone. quinone 30-37 transforming growth factor, beta 1 Rattus norvegicus 149-158 19233261-7 2009 PCB catechols, or ortho-dihydroxy metabolites, were up to 40% less active than their corresponding hydroquinone congeners, whereas monohydroxylated and quinone metabolites did not produce detectable oxidative damage over that of vehicle. quinone 104-111 pyruvate carboxylase Homo sapiens 0-3 19358519-12 2009 These studies suggest that the CYP3A4 mediated quinone methide formation was associated with dauricine bioactivation. quinone 47-54 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 31-37 19536200-5 2009 Quinone/quinol malfunction was postulated to activate ArcA, Fur, and PhoB in this study. quinone 0-7 arginine deiminase Escherichia coli 54-58 19346168-2 2009 Fabrication steps and electrochemical interaction of Au-MPA-LOx with L-lysine were monitored by general electrochemical methods like cyclic voltammetry (CV) and chronoamperometry (CA), and by a more advanced method, electrochemical impedance spectroscopy (EIS) in the presence of parabenzoquinone (PBQ) redox probe. quinone 280-296 lysyl oxidase Homo sapiens 60-63 19346168-2 2009 Fabrication steps and electrochemical interaction of Au-MPA-LOx with L-lysine were monitored by general electrochemical methods like cyclic voltammetry (CV) and chronoamperometry (CA), and by a more advanced method, electrochemical impedance spectroscopy (EIS) in the presence of parabenzoquinone (PBQ) redox probe. quinone 298-301 lysyl oxidase Homo sapiens 60-63 20183596-2 2009 It has been shown that a reaction of benzoquinone with aminopropenyl group at C-5-position of 2"-deoxyuridine or 2"-deoxycytidine and aminopropynyl group at the C-7-position of 8-aza-7-deazaadenosine under extremely mild conditions affords conjugated benzoxazole derivatives of nucleosides, which possess strong fluorescent properties. quinone 37-49 complement C5 Homo sapiens 78-81 20183596-2 2009 It has been shown that a reaction of benzoquinone with aminopropenyl group at C-5-position of 2"-deoxyuridine or 2"-deoxycytidine and aminopropynyl group at the C-7-position of 8-aza-7-deazaadenosine under extremely mild conditions affords conjugated benzoxazole derivatives of nucleosides, which possess strong fluorescent properties. quinone 37-49 complement C7 Homo sapiens 161-164 18704408-2 2009 ENOX2 is a growth-related protein of the external plasma membrane surface that is shed into the circulation and is inhibited by a series of quinone site inhibitors with anticancer activity. quinone 140-147 ecto-NOX disulfide-thiol exchanger 2 Gallus gallus 0-5 19236154-3 2009 Data generated by various groups indicate that Nrf2 induces the expression of a group of cytoprotective, antixenobiotic and antioxidant enzymes that include heme oxygenase-1, NAD(P)H:quinone oxidoreductase and enzymes of glutathione (GSH) metabolism such as gamma-glutamyl cysteine ligase, GSH transferases and so on. quinone 183-190 NFE2 like bZIP transcription factor 2 Homo sapiens 47-51 19029946-5 2009 In non-stressed wild-type cells, we did not detect any Yap4 in the nucleus, whereas Yap4 was present in the nuclei from quinone-stressed yeast cultures. quinone 120-127 Cin5p Saccharomyces cerevisiae S288C 84-88 19308924-7 2009 A 15-hydroxyl-17-demethoxy non-quinone analogue, DHQ3, exhibited stronger inhibition of Hsp90 ATPase activity (4.6-fold) than geldanamycin. quinone 31-38 heat shock protein 90 alpha family class A member 1 Homo sapiens 88-93 19778251-8 2009 From the known facts and above findings, it is suggested that depletion of reduced glutathione by hydroquinone in the presence of copper in catalase active RBC may be due to the formation of 1, 4 benzoquinone adduct of reduced glutathione and to some extent due to binding of copper to the thiol group of reduced glutathione rather than conversion to oxidized glutathione via reactive oxygen species. quinone 191-208 catalase Homo sapiens 140-148 19536200-6 2009 In support of this hypothesis, quinone-linked ArcA and Fur target expressions were significantly less perturbed by isobutanol under fermentative growth whereas quinol-linked PhoB target expressions remained activated, and isobutanol impeded growth on glycerol, which requires quinones, more than on glucose. quinone 31-38 arginine deiminase Escherichia coli 46-50 18945694-1 2008 Polymorphisms in NQO1, a gene coding for the phase II enzyme involved in the detoxification of quinone carcinogens, have been associated with childhood leukemia in some studies, although the observed direction and magnitude of effects have been inconsistent. quinone 95-102 NAD(P)H quinone dehydrogenase 1 Homo sapiens 17-21 18975953-2 2008 Upon the addition of tyrosinase, the tyrosine moiety was oxidized to quinone, which quenched the fluorescence of OPV-Tyr via intramolecular electron transfer from the phenylenevinylene unit to the quinone site. quinone 69-76 tyrosinase Homo sapiens 21-31 18975953-2 2008 Upon the addition of tyrosinase, the tyrosine moiety was oxidized to quinone, which quenched the fluorescence of OPV-Tyr via intramolecular electron transfer from the phenylenevinylene unit to the quinone site. quinone 197-204 tyrosinase Homo sapiens 21-31 19000905-6 2008 We further demonstrate that the in vitro quinone reduction by CBR4 generates superoxide through the redox cycling, and suggest that the enzyme may be involved in the induction of apoptosis by cytotoxic 9,10-phenanthrenequinone. quinone 41-48 carbonyl reductase 4 Homo sapiens 62-66 19159355-2 2008 The aim of the present study was to investigate whether mitochondrial VDAC1 reduces quinone antitumor drugs. quinone 84-91 voltage dependent anion channel 1 Homo sapiens 70-75 19159355-6 2008 In the quinone antitumor drugs, menadione (VK3), adriamycin and mitomycin C, mitochondrial VDAC1 bioreductively activated VK3. quinone 7-14 voltage dependent anion channel 1 Homo sapiens 91-96 19548356-5 2008 The intrinsic capacity of catechins to form quinone type metabolites upon their oxidation was demonstrated using incubations of epigallocatechin (EGC) and EGCG with tyrosinase and the GSH-trapping method. quinone 44-51 tyrosinase Mus musculus 165-175 18393300-3 2008 The hydroquinone derivative of 17AAG, 17AAG hydroquinone (17AAGH(2)), is considerably more water soluble and since we previously demonstrated that 17AAGH(2) was a more potent Hsp90 inhibitor than its parent quinone, it is a good candidate for clinical use and is currently in clinical trials. quinone 9-16 heat shock protein 90 alpha family class A member 1 Homo sapiens 175-180 18794327-1 2008 2,5-Diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone (RH1) is a novel antitumor diaziridinyl benzoquinone derivative designed to be bioactivated by the two-electron reductase NAD(P)H:quinone oxidoreductase (NQO1) and is currently in clinical trials. quinone 48-60 NAD(P)H quinone dehydrogenase 1 Homo sapiens 215-219 18993066-2 2008 Benzoyl protected quinone derivatives (14 and 35) as well as aryl beta-C-glycosyl compounds (18, 22, 23 and 34) showed IC(50) values of 0.77-5.27 microM against PTP1B, with compounds 18 and 23 bearing an acidic function being the most potent. quinone 18-25 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 161-166 18778717-0 2008 The effects of 1,4-benzoquinone on c-Myb and topoisomerase II in K-562 cells. quinone 15-31 MYB proto-oncogene, transcription factor Homo sapiens 35-40 18778717-3 2008 BQ has been shown to increase the activity of c-Myb, which is an important transcription factor involved in hematopoiesis, cell proliferation, and cell differentiation. quinone 0-2 MYB proto-oncogene, transcription factor Homo sapiens 46-51 18778717-7 2008 We hypothesized that BQ can increase c-Myb activity, which in turn increases Topo IIalpha promoter activity resulting in increased DNA strand breaks. quinone 21-23 MYB proto-oncogene, transcription factor Homo sapiens 37-42 18778717-10 2008 However, BQ (37microM for 24h) exposure caused a significant increase in Topo IIalpha promoter activity, which could be blocked by the overexpression of the DBD polypeptide, suggesting that BQ exposure increases Topo IIalpha promoter activity through the c-Myb signaling pathway. quinone 9-11 MYB proto-oncogene, transcription factor Homo sapiens 255-260 18778717-10 2008 However, BQ (37microM for 24h) exposure caused a significant increase in Topo IIalpha promoter activity, which could be blocked by the overexpression of the DBD polypeptide, suggesting that BQ exposure increases Topo IIalpha promoter activity through the c-Myb signaling pathway. quinone 190-192 MYB proto-oncogene, transcription factor Homo sapiens 255-260 18789703-2 2008 To date, quinone derivatives are among the most potent inhibitors of CDC25 phosphatase activity. quinone 9-16 cell division cycle 25C Homo sapiens 69-74 18674612-3 2008 We postulated that the TRP-2 beneficial effect observed in WM35 cells in the oxidative stress situation may relate to quinone metabolization and, more precisely, to the ability of TRP-2 to clear off related toxic metabolites, resulting in a global redox status modification. quinone 118-125 dopachrome tautomerase Homo sapiens 23-28 18674612-9 2008 These results suggest that TRP-2 acts on quinone metabolites other than DOPAchrome, e.g., in the catecholamine pathway, and limits their deleterious effects. quinone 41-48 dopachrome tautomerase Homo sapiens 27-32 18674612-6 2008 To address the issue of a possible TRP-2 beneficial effect toward quinone toxicity, cell survival experiments were then conducted in HEK cells using dopamine and hydroquinone at toxic concentrations. quinone 66-73 dopachrome tautomerase Homo sapiens 35-40 18802630-0 2008 Computational design, synthesis and biological evaluation of para-quinone-based inhibitors for redox regulation of the dual-specificity phosphatase Cdc25B. quinone 61-73 cell division cycle 25B Homo sapiens 148-154 18471987-2 2008 We review the kinetics of electron transfer and inhibitor binding that reveal functional interactions between the quinol oxidation site at center P and quinone reduction site at center N in opposite monomers in conjunction with electron equilibration between the cytochrome b subunits of the dimer. quinone 152-159 mitochondrially encoded cytochrome b Homo sapiens 263-275 18729332-5 2008 This is due to partitioning of the benzylic free radial intermediate between oxygen rebound to form 12-OH-NVP and loss of another hydrogen atom to form a reactive quinone methide, which inactivates P450. quinone 163-170 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 198-202 18729332-8 2008 We propose that the hepatotoxicity of NVP in humans is due to the quinone methide formed by P450 in the liver, while the skin rash may be due to the quinone methide formed in the skin by sulfation of 12-OH metabolite followed by loss of sulfate. quinone 66-73 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 92-96 18690748-4 2008 The X-ray crystal structure of E. coli Sdh shows that residues SdhB (G227), SdhC (D95), and SdhC (E101) are located at or near the entrance of a water channel that has been proposed to function as a proton wire connecting the cytoplasm to the quinone binding site. quinone 243-250 sorbitol dehydrogenase Gallus gallus 39-42 18690748-8 2008 In silico examination of the E. coli Sdh reveals a possible H-bonding network leading from the cytoplasm to the quinone binding site that involves SdhD (D15). quinone 112-119 sorbitol dehydrogenase Gallus gallus 37-40 18690748-8 2008 In silico examination of the E. coli Sdh reveals a possible H-bonding network leading from the cytoplasm to the quinone binding site that involves SdhD (D15). quinone 112-119 succinate dehydrogenase complex subunit D Gallus gallus 147-151 18662755-7 2008 This analysis reveals that (1) mono and di-chlorinated PCBs and their metabolites can be potential mutagens; (2) PCB benzoquinone metabolites could be carcinogenic but the weight of evidence is poor. quinone 117-129 pyruvate carboxylase Homo sapiens 55-58 19138946-4 2008 CYP1B1 favors quinone formation by catalyzing estrogen 4-hydroxylation, whereas NAD(P)H quinone oxidoreductase 1 (NQO1) catalyzes the protective reduction of quinones to catechols. quinone 14-21 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-6 18454936-2 2008 The extent of this initial cytochrome b reduction corresponded to a level of b(H) heme reduction of 33%-55% depending on the quinol/quinone ratio. quinone 132-139 cytochrome b Saccharomyces cerevisiae S288C 27-39 18254726-4 2008 However, recent studies indicate that QR2 may actually transform certain quinone substrates into more highly reactive compounds capable of causing cellular damage. quinone 73-80 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 38-41 21063328-1 2008 OBJECTIVE: To study the effect of 2,3,5-Trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone (AA-861) on intercellular adhesion molecule 1 (ICAM-1) and P-selectin expression, leukotriene B4 (LTB4) level, and myeloperoxidase (MPO) activity 24 hours after traumatic brain injury (TBI). quinone 83-99 intercellular adhesion molecule 1 Rattus norvegicus 112-145 18449627-9 2008 MonoHER acted as an uncompetitive CBR1 inhibitor for the small quinone substrate menadione Ki = 33 +/- 17 microM. quinone 63-70 carbonyl reductase 1 Homo sapiens 34-38 21063328-1 2008 OBJECTIVE: To study the effect of 2,3,5-Trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone (AA-861) on intercellular adhesion molecule 1 (ICAM-1) and P-selectin expression, leukotriene B4 (LTB4) level, and myeloperoxidase (MPO) activity 24 hours after traumatic brain injury (TBI). quinone 83-99 intercellular adhesion molecule 1 Rattus norvegicus 147-153 21063328-1 2008 OBJECTIVE: To study the effect of 2,3,5-Trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone (AA-861) on intercellular adhesion molecule 1 (ICAM-1) and P-selectin expression, leukotriene B4 (LTB4) level, and myeloperoxidase (MPO) activity 24 hours after traumatic brain injury (TBI). quinone 83-99 selectin P Rattus norvegicus 159-169 21063328-1 2008 OBJECTIVE: To study the effect of 2,3,5-Trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone (AA-861) on intercellular adhesion molecule 1 (ICAM-1) and P-selectin expression, leukotriene B4 (LTB4) level, and myeloperoxidase (MPO) activity 24 hours after traumatic brain injury (TBI). quinone 83-99 myeloperoxidase Rattus norvegicus 215-230 21063328-1 2008 OBJECTIVE: To study the effect of 2,3,5-Trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone (AA-861) on intercellular adhesion molecule 1 (ICAM-1) and P-selectin expression, leukotriene B4 (LTB4) level, and myeloperoxidase (MPO) activity 24 hours after traumatic brain injury (TBI). quinone 83-99 myeloperoxidase Rattus norvegicus 232-235 18455424-5 2008 In the present study, we show that bromocriptine upregulates the expression and activity of NQO1, attenuates the increase in the protein-bound quinone in H(2)O(2)-treated PC12 cells, and protects PC12 cells against oxidative damage. quinone 143-150 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 92-96 18567808-2 2008 Because numerous effects modulated by TQ can be linked to interference with the nuclear factor-kappaB (NF-kappa B) signaling, we investigated in detail the effect of this quinone on NF-kappa B pathway. quinone 171-178 nuclear factor kappa B subunit 1 Homo sapiens 103-113 18567808-2 2008 Because numerous effects modulated by TQ can be linked to interference with the nuclear factor-kappaB (NF-kappa B) signaling, we investigated in detail the effect of this quinone on NF-kappa B pathway. quinone 171-178 nuclear factor kappa B subunit 1 Homo sapiens 182-192 18444678-2 2008 The results also indicate that the metal ion-promoted electron transfer within the dyads is influenced by the electron accepting abilities of quinone units; dyad 2 with the strongest electron acceptor among the four dyads shows the strongest absorption and ESR signals attributed to TTF.+ in the presence of metal ions. quinone 142-149 ras homolog family member H Homo sapiens 283-286 18407675-6 2008 In the presence of tyrosinase, spectral evidence indicated that 2 was oxidized to the ortho-quinone, and upon incubation in the presence of GSH, two conjugates were detected and characterized by LC/MS/MS. quinone 92-99 tyrosinase Homo sapiens 19-29 18206117-3 2008 The reaction is mediated by the intermediate quinone forms of TQ, that is, glutathionyl-dihydrothymoquinone (DHTQ-GS) and dihydrothymoquinone (DHTQ), formed from direct interaction of TQ with GSH or NADH (NADPH). quinone 45-52 2,4-dienoyl-CoA reductase 1 Homo sapiens 199-203 18416817-7 2008 NQO1 has been implicated in carcinogenesis due to its role in quinone detoxification and in stabilization of p53. quinone 62-69 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-4 18329808-9 2008 Thus, the most potent active form as the activator of the Keap1/Nrf2 pathway, the quinone-type CA, will be produced inside the cells. quinone 82-89 kelch-like ECH-associated protein 1 Mus musculus 58-63 18329808-9 2008 Thus, the most potent active form as the activator of the Keap1/Nrf2 pathway, the quinone-type CA, will be produced inside the cells. quinone 82-89 nuclear factor, erythroid derived 2, like 2 Mus musculus 64-68 18206117-3 2008 The reaction is mediated by the intermediate quinone forms of TQ, that is, glutathionyl-dihydrothymoquinone (DHTQ-GS) and dihydrothymoquinone (DHTQ), formed from direct interaction of TQ with GSH or NADH (NADPH). quinone 45-52 2,4-dienoyl-CoA reductase 1 Homo sapiens 205-210 18361512-4 2008 A two-step mechanism of NQO1 activation is proposed involving (i) oxidation of diphenol inducers to their quinone derivatives and (ii) oxidation of two highly reactive thiol groups by these quinones of a protein involved in NQO1 induction. quinone 106-113 NAD(P)H quinone dehydrogenase 1 Homo sapiens 24-28 18199679-3 2008 The quinone methide triterpene celastrol, derived from a traditional Chinese medicinal herb, has numerous pharmacological properties, and it is a potent activator of the mammalian heat shock transcription factor HSF1. quinone 4-11 heat shock transcription factor 1 Homo sapiens 212-216 18361512-4 2008 A two-step mechanism of NQO1 activation is proposed involving (i) oxidation of diphenol inducers to their quinone derivatives and (ii) oxidation of two highly reactive thiol groups by these quinones of a protein involved in NQO1 induction. quinone 106-113 NAD(P)H quinone dehydrogenase 1 Homo sapiens 224-228 18232038-0 2008 Quinone replacements for small molecule insulin mimics. quinone 0-7 insulin Homo sapiens 40-47 18022268-1 2008 The neurotoxicity of dopamine (DA) quinones as dopaminergic neuron-specific oxidative stress is considered to play a role in the pathogenesis and/or progression of Parkinson"s disease (PD), since DA quinones conjugate with several key PD pathogenic molecules (e.g., tyrosine hydroxylase, alpha-synuclein and parkin) to form protein-bound quinone (quinoprotein) and consequently inhibit their functions. quinone 35-42 synuclein, alpha Mus musculus 288-303 18052105-9 2008 DNA damage induced by these equine quinones is significantly increased in cells containing ERs, leading us to hypothesize a mechanism involving ER binding/alkylation by the catchol/quinone, resulting in a "Trojan horse". quinone 35-42 estrogen receptor 1 Equus caballus 91-93 17514372-3 2008 Alternative or NDH-2-type NADH dehydrogenases are simple one subunit flavoenzymes that completely dissipate the redox energy of the NADH/quinone couple. quinone 137-144 DExH-box helicase 9 Homo sapiens 15-20 19734119-6 2008 Inhibition of WST-1/mPMS reduction by BQ and MNQ but not DMNQ was fully reversed by NAC. quinone 38-40 NLR family, pyrin domain containing 1A Mus musculus 84-87 19734119-7 2008 Treatment with DMNQ, MNQ and to a lesser extent BQ inhibited cell proliferation as determined by MTT reduction at 48 h. The effects of BQ and MNQ were reversed by NAC through covalent bonding to BQ and MNQ, but not DMNQ. quinone 48-50 NLR family, pyrin domain containing 1A Mus musculus 163-166 19734119-7 2008 Treatment with DMNQ, MNQ and to a lesser extent BQ inhibited cell proliferation as determined by MTT reduction at 48 h. The effects of BQ and MNQ were reversed by NAC through covalent bonding to BQ and MNQ, but not DMNQ. quinone 135-137 NLR family, pyrin domain containing 1A Mus musculus 163-166 19734119-7 2008 Treatment with DMNQ, MNQ and to a lesser extent BQ inhibited cell proliferation as determined by MTT reduction at 48 h. The effects of BQ and MNQ were reversed by NAC through covalent bonding to BQ and MNQ, but not DMNQ. quinone 135-137 NLR family, pyrin domain containing 1A Mus musculus 163-166 19098979-9 2008 With respect to the role of GST isoforms in cellular protection against quinone toxicity, we observed that the Gtt2 deficient strain was unable to overcome lipid peroxidation, even after a plumbagin pre-treatment, indicating that this treatment did not improve tolerance when compared with the wild type strain. quinone 72-79 glutathione transferase GTT2 Saccharomyces cerevisiae S288C 111-115 19098979-12 2008 In addition, the Gtt2 isoform seemed to act as a general protective factor involved in quinone detoxification. quinone 87-94 glutathione transferase GTT2 Saccharomyces cerevisiae S288C 17-21 17975886-5 2007 The quinone-forming family, including NCX 4040 and conisogenic bromides and mesylate, was rapidly bioactivated to a quinone, which gave activation of ARE and consequent induction of NQO1 in liver cells. quinone 4-11 T cell leukemia homeobox 2 Homo sapiens 38-41 17979524-8 2007 We hypothesize that quinone metabolites or other reactive forms of capsaicin may bind covalently to NQO1 and thereby inhibit its activity, leading to production of ROS. quinone 20-27 NAD(P)H quinone dehydrogenase 1 Homo sapiens 100-104 17941699-11 2007 The results demonstrate fundamental differences between the pharmacological properties of CA1 and CA4 that provide two possible explanations for their differential activities in vivo: oxidative activation to a quinone intermediate likely to bind to protein thiols and possibly to nucleic acids and stimulation of oxidative stress by enhancing superoxide/hydrogen peroxide production. quinone 210-217 carbonic anhydrase 4 Homo sapiens 98-101 19568319-2 2008 Utilizing our chimera approach, which encompasses the quinone moiety of geldanamycin and the resorcinol moiety of radicicol, molecules have been produced that are highly effective inhibitors of the Hsp90 protein folding machinery. quinone 54-61 heat shock protein 90 alpha family class A member 1 Homo sapiens 198-203 18020424-9 2007 Isoform profiling with recombinant human P450s suggested that CYP2C9 is primarily responsible for the formation of this reactive quinone intermediate. quinone 129-136 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 62-68 17975886-5 2007 The quinone-forming family, including NCX 4040 and conisogenic bromides and mesylate, was rapidly bioactivated to a quinone, which gave activation of ARE and consequent induction of NQO1 in liver cells. quinone 4-11 NAD(P)H quinone dehydrogenase 1 Homo sapiens 182-186 17975886-5 2007 The quinone-forming family, including NCX 4040 and conisogenic bromides and mesylate, was rapidly bioactivated to a quinone, which gave activation of ARE and consequent induction of NQO1 in liver cells. quinone 116-123 T cell leukemia homeobox 2 Homo sapiens 38-41 17975886-5 2007 The quinone-forming family, including NCX 4040 and conisogenic bromides and mesylate, was rapidly bioactivated to a quinone, which gave activation of ARE and consequent induction of NQO1 in liver cells. quinone 116-123 NAD(P)H quinone dehydrogenase 1 Homo sapiens 182-186 17893042-6 2007 Two different strategies were employed to ascertain the NQO1 activity in estrogen quinone reduction. quinone 82-89 NAD(P)H quinone dehydrogenase 1 Homo sapiens 56-60 18089707-1 2007 NAD(P)H:quinone oxidoreductase-1 (NQO1) is a potential target for therapeutic intervention but attempts to exploit NQO1 using quinone-based bioreductive prodrugs have been largely compromised by toxicity to organs that inherently express high levels of NQO1. quinone 8-15 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 18089707-1 2007 NAD(P)H:quinone oxidoreductase-1 (NQO1) is a potential target for therapeutic intervention but attempts to exploit NQO1 using quinone-based bioreductive prodrugs have been largely compromised by toxicity to organs that inherently express high levels of NQO1. quinone 8-15 NAD(P)H quinone dehydrogenase 1 Homo sapiens 115-119 18089707-1 2007 NAD(P)H:quinone oxidoreductase-1 (NQO1) is a potential target for therapeutic intervention but attempts to exploit NQO1 using quinone-based bioreductive prodrugs have been largely compromised by toxicity to organs that inherently express high levels of NQO1. quinone 8-15 NAD(P)H quinone dehydrogenase 1 Homo sapiens 115-119 18089707-2 2007 In an attempt to circumvent this problem, this study describes the development of a tripartite quinone-based drug delivery system, the ultimate objective of which is to release a targeted therapeutic agent following the reduction of a quinone "trigger" by NQO1. quinone 95-102 NAD(P)H quinone dehydrogenase 1 Homo sapiens 256-260 18089707-2 2007 In an attempt to circumvent this problem, this study describes the development of a tripartite quinone-based drug delivery system, the ultimate objective of which is to release a targeted therapeutic agent following the reduction of a quinone "trigger" by NQO1. quinone 235-242 NAD(P)H quinone dehydrogenase 1 Homo sapiens 256-260 17878162-6 2007 Studies with purified PTP1B and 1,2-NQ showed that the reduction in enzyme activity was due to a nucleophilic attack by the quinone on the enzyme, to form covalent bonds. quinone 124-131 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 22-38 17878162-7 2007 Matrix-assisted laser desorption and ionization time-of-flight mass spectrometry analysis and mutation experiments revealed that PTP1B inactivation was primarily due to covalent attachment of the quinone to Cys-121 of the enzyme, with binding to His-25 and Cys-215 as well. quinone 196-203 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 129-134 17907785-0 2007 NADPH-dependent covalent binding of [3H]paroxetine to human liver microsomes and S-9 fractions: identification of an electrophilic quinone metabolite of paroxetine. quinone 131-138 2,4-dienoyl-CoA reductase 1 Homo sapiens 0-5 17701401-3 2007 The benzoquinone derivatization is shown to allow the accurate selection of cysteine-containing peptides of bovine serum albumin tryptic digest by diagonal reversed-phase chromatography, which consists of one primary and a series of secondary identical liquid chromatographic separations, before and after a cysteinyl-targeted modification of the peptides by benzoquinone compounds. quinone 4-16 albumin Homo sapiens 121-128 17892300-3 2007 Under mild reduction, induced by S2O4(2-) in aqueous solution, the resulting NDI radical anion (NDI*-) undergoes a monomolecular fragmentation to yield a new transient species, where the NDI radical anion is tethered to a quinone methide moiety. quinone 222-229 arginine vasopressin receptor 2 Homo sapiens 77-80 17892300-3 2007 Under mild reduction, induced by S2O4(2-) in aqueous solution, the resulting NDI radical anion (NDI*-) undergoes a monomolecular fragmentation to yield a new transient species, where the NDI radical anion is tethered to a quinone methide moiety. quinone 222-229 arginine vasopressin receptor 2 Homo sapiens 96-99 17892300-3 2007 Under mild reduction, induced by S2O4(2-) in aqueous solution, the resulting NDI radical anion (NDI*-) undergoes a monomolecular fragmentation to yield a new transient species, where the NDI radical anion is tethered to a quinone methide moiety. quinone 222-229 arginine vasopressin receptor 2 Homo sapiens 96-99 17785456-6 2007 Cell-free studies using novel near infrared fluorescence methodology for the detection of covalent protein-ortho-quinone adducts showed that although covalent modification of alpha-syn occurs, this does not affect alpha-syn fibril formation. quinone 113-120 synuclein alpha Homo sapiens 175-184 17701401-3 2007 The benzoquinone derivatization is shown to allow the accurate selection of cysteine-containing peptides of bovine serum albumin tryptic digest by diagonal reversed-phase chromatography, which consists of one primary and a series of secondary identical liquid chromatographic separations, before and after a cysteinyl-targeted modification of the peptides by benzoquinone compounds. quinone 359-371 albumin Homo sapiens 121-128 17722905-4 2007 Among the newly synthesized compounds, compounds 13 and 16, in which the imidazole was replaced by a quinone and a hydroquinone and which bear a hydroxy group on the indole moiety, are the most potent Chk1 inhibitors in this series with IC50 values of 27 and 23 nM, respectively. quinone 101-108 checkpoint kinase 1 Homo sapiens 201-205 17850125-9 2007 Furthermore, the ability of the compounds to counteract the oxidative stress in a human neuronal-like cellular system (SH-SY5Y cells) was assayed, in both the presence and absence of NQO1, an enzyme able to generate and maintain the reduced form of quinone. quinone 249-256 NAD(P)H quinone dehydrogenase 1 Homo sapiens 183-187 17182266-8 2007 VKOR, an essential enzyme in mammalian systems, acts to convert Vitamin K epoxide, formed by Vitamin K carboxylase, to its (initial) quinone form for cellular reuse. quinone 133-140 vitamin K epoxide reductase complex subunit 1 Homo sapiens 0-4 17662999-10 2007 Experiments with BDGA measured over a wide range of conditions, in the absence and in the presence of reducing agents, confirm recent studies that have suggested that the reduced dihydroquinone form of the drug binds to Hsp90 considerably more tightly than the non-reduced quinone species. quinone 186-193 heat shock protein 90 alpha family class A member 1 Homo sapiens 220-225 17471452-2 2007 It was found that the cationic surfactant cetyltrimethylammonium bromide (CTAB) could cause the structural transformation of fluorescein from the quinone to the spirolactone form, and greatly enhance the CL intensity of the fluorescein-human serum albumin (HSA) complex. quinone 146-153 albumin Homo sapiens 224-255 17937775-2 2007 Favourable hydrogen bonds between ligand and NQO1, and parallel orientation between ligand and flavin adenine dinucleotide could explain the difference of metabolism rate (in micromol/min/mg) for quinone analogues. quinone 196-203 NAD(P)H quinone dehydrogenase 1 Homo sapiens 45-49 17471452-2 2007 It was found that the cationic surfactant cetyltrimethylammonium bromide (CTAB) could cause the structural transformation of fluorescein from the quinone to the spirolactone form, and greatly enhance the CL intensity of the fluorescein-human serum albumin (HSA) complex. quinone 146-153 albumin Homo sapiens 257-260 17369345-6 2007 The biochemical characterization of purified U. maydis DHODH overproduced in Escherichia coli revealed that the U. maydis enzyme uses quinone electron acceptor Q6 and is resistant to several commonly used DHODH inhibitors. quinone 134-141 dihydroorotate dehydrogenase (quinone) Homo sapiens 55-60 19356045-0 2007 Involvement of P-glycoprotein and multidrug resistance associated protein 1 in the transport of tanshinone IIB, a primary active diterpenoid quinone from the roots of Salvia miltiorrhiza, across the blood-brain barrier. quinone 141-148 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 15-29 17235490-3 2007 Phospholipase A(2) treatment of thylakoids (a) inhibited electron transfer from the primary quinone acceptor Q(A) to the secondary quinone acceptor Q(B), (b) retarded electron transfer from the manganese cluster to the redox-active tyrosine Z, (c) decreased the extent of flash-induced oxidation of tyrosine Z and dark-stable tyrosine D in parallel, and (d) inhibited PSII reaction centres such that electron flow to silicomolybdate in continuous light was inhibited. quinone 92-99 phospholipase A2 group IB Homo sapiens 0-17 17235490-3 2007 Phospholipase A(2) treatment of thylakoids (a) inhibited electron transfer from the primary quinone acceptor Q(A) to the secondary quinone acceptor Q(B), (b) retarded electron transfer from the manganese cluster to the redox-active tyrosine Z, (c) decreased the extent of flash-induced oxidation of tyrosine Z and dark-stable tyrosine D in parallel, and (d) inhibited PSII reaction centres such that electron flow to silicomolybdate in continuous light was inhibited. quinone 131-138 phospholipase A2 group IB Homo sapiens 0-17 17187958-0 2007 Cytochrome P450 destruction by benzene metabolites 1,4-benzoquinone and 1,4-hydroquinone and the formation of hydroxyl radicals in minipig liver microsomes. quinone 51-67 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 17187958-2 2007 Since minipigs have been proposed as a suitable model species in toxicological and pharmacological research, the aim of this study was to explore mechanisms by which catechol, 1,4-hydroquinone and 1,4-benzoquinone destroy cytochrome P450 (P450) and induce oxidative stress in minipig liver microsomes. quinone 197-213 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 222-237 17614109-6 2007 Reduced to oxidized glutathione ratios (GSH:GSSG) were also assessed as well as hydroquinone and benzoquinone"s effects on c-Myb protein levels and activation of a transiently transfected reporter construct. quinone 97-109 MYB proto-oncogene, transcription factor Gallus gallus 123-128 17614109-9 2007 SOD was able to prevent DCFDA fluorescence and c-Myb activity caused by benzoquinone and hydroquinone only. quinone 72-84 MYB proto-oncogene, transcription factor Gallus gallus 47-52 17369345-6 2007 The biochemical characterization of purified U. maydis DHODH overproduced in Escherichia coli revealed that the U. maydis enzyme uses quinone electron acceptor Q6 and is resistant to several commonly used DHODH inhibitors. quinone 134-141 dihydroorotate dehydrogenase (quinone) Homo sapiens 205-210 17259450-3 2007 We have previously observed that exposure to or induction of NAD(P)H:quinone reductase (QR1), the enzyme that catalyzes the reduction of quinone, effectively protects DA cells. quinone 69-76 NAD(P)H quinone dehydrogenase 1 Homo sapiens 88-91 17253627-8 2007 Most treatments of HaCaT cells and A3 lymphocytes with BaP or its quinone intermediates resulted in significant decreases in viability (P < 0.05); dose-dependent decreases in cell viability were detected at concentrations of 0.1, 1, and 5 muM, but none of these treatments resulted in decreases of >30%. quinone 66-73 prohibitin 2 Homo sapiens 55-58 17200125-0 2007 Roles of bound quinone in the single subunit NADH-quinone oxidoreductase (Ndi1) from Saccharomyces cerevisiae. quinone 15-22 NADH-ubiquinone reductase (H(+)-translocating) NDI1 Saccharomyces cerevisiae S288C 74-78 17161514-4 2007 Considering that many toxic effects of AhR ligands are dependent on AhR activation, our first objective was to determine if benzene, hydroquinone (HQ) or benzoquinone (BQ) could activate the AhR. quinone 154-166 aryl-hydrocarbon receptor Mus musculus 39-42 17123468-6 2007 Superoxide generation in cells was strongly potentiated by blocking the quinone site of Complex II with thenoyltrifluoroacetone, supporting the involvement of cytochrome b560 to drive electrons for increasing superoxide. quinone 72-79 mitochondrially encoded cytochrome b Homo sapiens 159-171 17240992-0 2007 Evidence for a novel quinone-binding site in the photosystem II (PS II) complex that regulates the redox potential of cytochrome b559. quinone 21-28 mitochondrially encoded cytochrome b Homo sapiens 118-130 17298444-0 2007 Lot6p from Saccharomyces cerevisiae is a FMN-dependent reductase with a potential role in quinone detoxification. quinone 90-97 flavin-dependent quinone reductase Saccharomyces cerevisiae S288C 0-5 17161514-4 2007 Considering that many toxic effects of AhR ligands are dependent on AhR activation, our first objective was to determine if benzene, hydroquinone (HQ) or benzoquinone (BQ) could activate the AhR. quinone 154-166 aryl-hydrocarbon receptor Mus musculus 68-71 17161514-4 2007 Considering that many toxic effects of AhR ligands are dependent on AhR activation, our first objective was to determine if benzene, hydroquinone (HQ) or benzoquinone (BQ) could activate the AhR. quinone 154-166 aryl-hydrocarbon receptor Mus musculus 68-71 17161514-4 2007 Considering that many toxic effects of AhR ligands are dependent on AhR activation, our first objective was to determine if benzene, hydroquinone (HQ) or benzoquinone (BQ) could activate the AhR. quinone 168-170 aryl-hydrocarbon receptor Mus musculus 39-42 17161514-5 2007 Secondly, because the AhR regulates a number of enzymes involved in oxidative stress pathways, we sought to determine if the AhR had a role in HQ and BQ induced production of reactive oxygen species (ROS). quinone 150-152 aryl-hydrocarbon receptor Mus musculus 125-128 17161514-7 2007 Immunofluorescence staining showed cytosolic localization of the AhR after 2h incubations with benzene, HQ or BQ. quinone 110-112 aryl-hydrocarbon receptor Mus musculus 65-68 17161514-9 2007 Dichlorodihydrofluorescein staining of cells exposed to benzene, HQ or BQ revealed that the presence of the AhR did not affect BQ and HQ induced ROS production. quinone 71-73 aryl-hydrocarbon receptor Mus musculus 108-111 17234793-4 2007 CYP1B1 oxidized E2 to the catechol 4-OHE2 and the labile quinone 4-hydroxyestradiol-quinone to produce 4-OHE2-N7-Gua and 4-OHE2-N3-Ade in a time- and concentration-dependent manner. quinone 57-64 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-6 17546202-5 2007 A comparison of X-ray data of PETNR, mammalian NAD(P)H : quinone oxidoreductase (NQO1), and Enterobacter cloacae nitroreductase, which reduce quinones in a two-electron way, and their reactivity revealed that PETNR is much less reactive, and much less sensitive to the quinone substrate steric effects than NQO1. quinone 57-64 NAD(P)H quinone dehydrogenase 1 Homo sapiens 81-85 17546202-6 2007 This may be attributed to the lack of pi-pi stacking between quinone and the displaced aromatic amino acid in the active center, e.g., with Phe-178" in NQO1. quinone 61-68 NAD(P)H quinone dehydrogenase 1 Homo sapiens 152-156 18001220-1 2007 Tyrosinase is expressed in melanoma cells and catalyzes the formation of 3,3",4",5,7-pentahydroxyflavone (quercetin) into reactive quinone species and subsequent glutathionyl adducts. quinone 131-138 tyrosinase Homo sapiens 0-10 17131995-3 2006 The tyrosine units were reacted with tyrosinase/O2 to yield the respective l-DOPA and quinone derivatives. quinone 86-93 tyrosinase Homo sapiens 37-47 17305492-0 2007 Identification of a novel intestinal first pass metabolic pathway: NQO1 mediated quinone reduction and subsequent glucuronidation. quinone 81-88 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 67-71 17305492-8 2007 Dicoumarol, a specific inhibitor of the NAD(P)H dependent quinone oxidoreductase (NQO1), significantly inhibited the metabolic elimination of TS in a noncompetitive way, suggesting that NQO1 was responsible for the quinone reduction of TS to form the catechol intermediate. quinone 58-65 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 82-86 17305492-8 2007 Dicoumarol, a specific inhibitor of the NAD(P)H dependent quinone oxidoreductase (NQO1), significantly inhibited the metabolic elimination of TS in a noncompetitive way, suggesting that NQO1 was responsible for the quinone reduction of TS to form the catechol intermediate. quinone 58-65 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 186-190 17040906-3 2006 Although dicumarol has been used as an inhibitor of the two-electron reductase NAD(P)H:quinone oxidoreductase (NQO1), dicumarol is also thought to affect quinone-mediated electron transfer reactions in the mitochondria, leading to the production of superoxide (O2*-) and hydrogen peroxide (H(2)O(2)). quinone 87-94 NAD(P)H quinone dehydrogenase 1 Homo sapiens 111-115 17165926-2 2006 The aziridinyl pyrrolidine and quinone subunits are coupled regioselectively to arrive at an enamine that is prepared for C10 homologation. quinone 31-38 homeobox C10 Homo sapiens 122-125 17131995-5 2006 The quinone-functionalized peptide associated with the QDs was cleaved by thrombin, a process that restored the luminescence of the QDs. quinone 4-11 coagulation factor II, thrombin Homo sapiens 74-82 16973179-11 2006 In conclusion, our high-throughput screening models in combination with quantitative assessment of changes in gene expression profiles identified the avarol derivative 13, a benzylamine derivative of avarol at the 4" position of benzoquinone ring, as an interesting anti-psoriatic drug candidate that inhibits keratinocyte cell growth and TNFalpha and COX-2 expression. quinone 229-241 tumor necrosis factor Homo sapiens 339-347 17723784-3 2006 The dephenolization process was realized by recycling the phenol solutions through the bioreactor connected to a chitosan trap in order to remove the colored quinone-type products of the tyrosinase reactions. quinone 158-165 tyrosinase Homo sapiens 187-197 16973179-11 2006 In conclusion, our high-throughput screening models in combination with quantitative assessment of changes in gene expression profiles identified the avarol derivative 13, a benzylamine derivative of avarol at the 4" position of benzoquinone ring, as an interesting anti-psoriatic drug candidate that inhibits keratinocyte cell growth and TNFalpha and COX-2 expression. quinone 229-241 mitochondrially encoded cytochrome c oxidase II Homo sapiens 352-357 17073429-1 2006 The nucleophilic addition of the aminothiols homocysteine (HCY), cysteine (CYS), and glutathione (GSH) to the electrogenerated quinone of fluorone black (1) via the ECE mechanism is reported. quinone 127-134 endothelin converting enzyme 1 Homo sapiens 165-168 17083262-4 2006 In contrast, PRH-bridged substrates experience overall insertion of quinone into the P-H bond to give the anionic compounds (H-DBU)[Mo(2)Cp2{mu-PR(OC6H4OH)}(CO)4], which upon acidification yield the corresponding neutral hydrides. quinone 68-75 hematopoietically expressed homeobox Homo sapiens 13-16 16517149-1 2006 tNOX, a novel cell surface protein related to unregulated growth and drug response of cancer cells, has been proposed as the cellular target for the anticancer action of various quinone site inhibitors with anticancer activity including the polyphenol (-)-epigallocatechin-3-gallate (EGCg). quinone 178-185 ecto-NOX disulfide-thiol exchanger 2 Mus musculus 0-4 17077902-6 2006 The properties of the quinone and donor radicals involved and the pH and concentration dependences of Phi(-O2) are described. quinone 22-29 glucose-6-phosphate isomerase Homo sapiens 102-105 16580891-2 2006 The method is based on immobilized glucose oxidase (GOx) on the topside of gold mercaptopropionic acid self-assembled monolayers (Au-MPA-GOx SAMs) electrode and mediation of electron transfer by parabenzoquinone (PBQ). quinone 195-211 hydroxyacid oxidase 1 Homo sapiens 35-50 17046835-6 2006 Quinone-induced oxidative stress and the chemopreventive agent sulforaphane inhibit Keap1-dependent ubiquitination of PGAM5. quinone 0-7 kelch like ECH associated protein 1 Homo sapiens 84-89 17046835-6 2006 Quinone-induced oxidative stress and the chemopreventive agent sulforaphane inhibit Keap1-dependent ubiquitination of PGAM5. quinone 0-7 PGAM family member 5, mitochondrial serine/threonine protein phosphatase Homo sapiens 118-123 16969075-3 2006 We therefore synthesized a nonquinone sulfone derivative, H32, which has a sufone group substituting the quinone. quinone 30-37 H3 clustered histone 14 Homo sapiens 58-61 17014438-4 2006 PPD patch-test positive patients were patch-tested to BB and BQ. quinone 61-63 4-hydroxyphenylpyruvate dioxygenase Homo sapiens 0-3 17094478-2 2006 The aim of this study was to study the effect of 2,5 bis-[1-aziridinyl]-1,4 benzoquinone (DZQ), an antitumor quinone bioactivated by NQO1, on HeLa and HepG2 cells cultured at various cell densities. quinone 81-88 NAD(P)H quinone dehydrogenase 1 Homo sapiens 133-137 16580891-2 2006 The method is based on immobilized glucose oxidase (GOx) on the topside of gold mercaptopropionic acid self-assembled monolayers (Au-MPA-GOx SAMs) electrode and mediation of electron transfer by parabenzoquinone (PBQ). quinone 195-211 hydroxyacid oxidase 1 Homo sapiens 52-55 16580891-2 2006 The method is based on immobilized glucose oxidase (GOx) on the topside of gold mercaptopropionic acid self-assembled monolayers (Au-MPA-GOx SAMs) electrode and mediation of electron transfer by parabenzoquinone (PBQ). quinone 213-216 hydroxyacid oxidase 1 Homo sapiens 35-50 16580891-2 2006 The method is based on immobilized glucose oxidase (GOx) on the topside of gold mercaptopropionic acid self-assembled monolayers (Au-MPA-GOx SAMs) electrode and mediation of electron transfer by parabenzoquinone (PBQ). quinone 213-216 hydroxyacid oxidase 1 Homo sapiens 52-55 17015278-1 2006 RH1 (2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone), which is currently in clinical trials, is a diaziridinyl benzoquinone bioreductive anticancer drug that was designed to be activated by the obligate two-electron reductive enzyme NAD(P)H quinone oxidoreductase 1 (NQO1). quinone 53-65 NAD(P)H quinone dehydrogenase 1 Homo sapiens 247-279 17015278-1 2006 RH1 (2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone), which is currently in clinical trials, is a diaziridinyl benzoquinone bioreductive anticancer drug that was designed to be activated by the obligate two-electron reductive enzyme NAD(P)H quinone oxidoreductase 1 (NQO1). quinone 53-65 NAD(P)H quinone dehydrogenase 1 Homo sapiens 281-285 16906772-9 2006 On the basis of (1) the differential ability of quinone-treated enzyme to bind circular and linear DNA molecules and (2) the generation of salt-stable noncovalent complexes between topoisomerase IIalpha and circular plasmids in the presence of PCB quinones, it appears that these compounds alter enzyme function (at least in part) by blocking the N-terminal gate of the protein. quinone 48-55 pyruvate carboxylase Homo sapiens 244-247 16765324-2 2006 The present studies investigate the role of NQO2 in metabolic detoxification/activation of quinones and quinone based anti-tumor drugs. quinone 91-98 N-ribosyldihydronicotinamide quinone reductase 2 Mus musculus 44-48 16884501-2 2006 Type II NADH dehydrogenases (NDH-2) are monomeric enzymes that catalyse quinone reduction and allow electrons to enter the respiratory chain in different organisms including higher plant mitochondria, bacteria and yeasts. quinone 72-79 NADH-ubiquinone reductase (H(+)-translocating) NDE2 Saccharomyces cerevisiae S288C 29-34 16430935-3 2006 Thus, we investigated the relationship between cytochrome P450 systems and quinone toxicity for rat primary hepatocytes using an arylator, 1,4-benzoquinone (BQ), and a redox cycler, 2,3-dimethoxy-1,4-naphthoquinone (DMNQ). quinone 75-82 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 47-62 16430935-3 2006 Thus, we investigated the relationship between cytochrome P450 systems and quinone toxicity for rat primary hepatocytes using an arylator, 1,4-benzoquinone (BQ), and a redox cycler, 2,3-dimethoxy-1,4-naphthoquinone (DMNQ). quinone 157-159 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 47-62 16430935-5 2006 Pretreatment with cytochrome P450 inhibitors, such as SKF-525A (SKF), ketoconazole and 2-methy-1,2-di-3-pyridyl-1-propanone, enhanced the hepatocyte toxicity induced by DMNQ but did not affect BQ-induced hepatocyte toxicity. quinone 193-195 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 18-33 17163756-2 2006 They spotlight the higher affinity of ansamycins" hydroquinone over the quinone form for Hsp90 and further discuss its possible contribution to ansamycins" tumor selectivity. quinone 55-62 heat shock protein 90 alpha family class A member 1 Homo sapiens 89-94 16478651-1 2006 In human liver, the two-electron reduction of quinone compounds, such as menadione is catalyzed by cytosolic carbonyl reductase (CBR) and NAD(P)H:quinone oxidoreductase (NQO1) activities. quinone 46-53 carbonyl reductase 1 Homo sapiens 109-127 16478651-1 2006 In human liver, the two-electron reduction of quinone compounds, such as menadione is catalyzed by cytosolic carbonyl reductase (CBR) and NAD(P)H:quinone oxidoreductase (NQO1) activities. quinone 46-53 carbonyl reductase 1 Homo sapiens 129-132 16478651-1 2006 In human liver, the two-electron reduction of quinone compounds, such as menadione is catalyzed by cytosolic carbonyl reductase (CBR) and NAD(P)H:quinone oxidoreductase (NQO1) activities. quinone 46-53 crystallin zeta Homo sapiens 146-168 16478651-1 2006 In human liver, the two-electron reduction of quinone compounds, such as menadione is catalyzed by cytosolic carbonyl reductase (CBR) and NAD(P)H:quinone oxidoreductase (NQO1) activities. quinone 46-53 NAD(P)H quinone dehydrogenase 1 Homo sapiens 170-174 16841962-0 2006 Myeloperoxidase-catalyzed metabolism of etoposide to its quinone and glutathione adduct forms in HL60 cells. quinone 57-64 myeloperoxidase Homo sapiens 0-15 16774642-3 2006 We propose that the enzyme is a member of the DHODH family 2, which comprises mitochondrially bound enzymes, with quinone as the direct electron acceptor and oxygen as the final electron acceptor. quinone 114-121 dihydroorotate dehydrogenase (quinone) Homo sapiens 46-51 16782352-7 2006 Consistent with other para-quinones, some members of this series generated intracellular reactive oxygen species and the in vitro enzyme inhibition was mitigated by addition of reductants or catalase. quinone 22-35 catalase Homo sapiens 191-199 16781461-6 2006 As compared to wild-type cells, Nrf2(-/-) cells were much more susceptible to cytotoxicity induced by reactive oxygen or nitrogen species, 4-hydroxy-2-nonenal, 1,4-hydroquinone, or 1,4-benzoquinone. quinone 181-197 nuclear factor, erythroid derived 2, like 2 Mus musculus 32-36 16476401-2 2006 Oxidation of these substrates by this reagent was analogous to oxidation by tyrosinase with molecular oxygen, although the procedure showed several advantages over the enzymatic method in that oxidation took place almost immediately and quinone stability was favored because no substrate remained. quinone 237-244 tyrosinase Homo sapiens 76-86 16524433-2 2006 Four N-substituted dopamine derivatives have been prepared and quinone formation studied using pulse radiolysis and tyrosinase-oximetry. quinone 63-70 tyrosinase Homo sapiens 116-126 16597370-8 2006 Tanshinone IIA was the main diterpene quinone in S. miltiorrhiza. quinone 38-45 ATPase, class II, type 9A Mus musculus 11-14 16407191-0 2006 Structural and computational analysis of the quinone-binding site of complex II (succinate-ubiquinone oxidoreductase): a mechanism of electron transfer and proton conduction during ubiquinone reduction. quinone 45-52 oxidoreductase Escherichia coli 102-116 16407191-2 2006 This work presents a structural analysis of the quinone-binding site (Q-site) identified in succinate:ubiquinone oxidoreductase (SQR) from Escherichia coli. quinone 48-55 oxidoreductase Escherichia coli 113-127 16505371-9 2006 Detoxification by NAC greatly attenuates CHOP induction in arylating quinone-treated cells, suggesting that ER stress is a cellular mechanism for arylating quinone cytotoxicity. quinone 69-76 DNA damage inducible transcript 3 Homo sapiens 41-45 16505371-9 2006 Detoxification by NAC greatly attenuates CHOP induction in arylating quinone-treated cells, suggesting that ER stress is a cellular mechanism for arylating quinone cytotoxicity. quinone 156-163 DNA damage inducible transcript 3 Homo sapiens 41-45 16468397-6 2006 With a hypochlorite dose of 57 micromol/L (4 ppm as Cl2), 88% of the acetaminophen (10 micromol/L initial) was transformed in 1 h. The two quinoidal oxidation products 1,4-benzoquinone and NAPQI accounted for 25% and 1.5% of the initial acetaminophen concentration, respectively, at a 1 h reaction time. quinone 168-184 endogenous retrovirus group W member 5 Homo sapiens 52-55 16520231-3 2006 Toxicity arising from the high susceptibility of quinone toward endogenous nucleophiles (Q-TOX) was detected using OxyR(+) cells, in the presence of a nitric oxide donor to promote the quinol oxidation to the corresponding quinone. quinone 49-56 thymocyte selection associated high mobility group box Homo sapiens 91-94 16520231-3 2006 Toxicity arising from the high susceptibility of quinone toward endogenous nucleophiles (Q-TOX) was detected using OxyR(+) cells, in the presence of a nitric oxide donor to promote the quinol oxidation to the corresponding quinone. quinone 223-230 thymocyte selection associated high mobility group box Homo sapiens 91-94 16595077-1 2006 The NAD(P)H:quinone acceptor oxidoreductase (NQO) gene family belongs to the flavoprotein clan and, in the human genome, consists of two genes (NQO1 and NQO2). quinone 12-19 NAD(P)H quinone dehydrogenase 1 Homo sapiens 144-148 16595077-1 2006 The NAD(P)H:quinone acceptor oxidoreductase (NQO) gene family belongs to the flavoprotein clan and, in the human genome, consists of two genes (NQO1 and NQO2). quinone 12-19 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 153-157 16343695-7 2006 Pretreatment with the sulfhydryl antioxidant N-acetylcysteine or the quinone reductase inducer dimethyl fumarate prevents the ETC inhibition and cytochrome c release following BH4 exposure, suggesting the involvement of quinone products. quinone 69-76 cytochrome c, somatic Homo sapiens 145-157 16929382-6 2006 Another important but poorly understood factor enhancing the reactivity of nitroaromatics is their ability to bind at the dicumarol/quinone binding site in the active center of NQO1. quinone 132-139 NAD(P)H quinone dehydrogenase 1 Homo sapiens 177-181 17379941-5 2006 Because the drug-inhibited ECTO-NOX protein, tNOX was utilized, the enlargement was inhibited by capsaicin, a quinone site tNOX inhibitor specific for tNOX. quinone 110-117 ecto-NOX disulfide-thiol exchanger 2 Homo sapiens 45-49 17379941-5 2006 Because the drug-inhibited ECTO-NOX protein, tNOX was utilized, the enlargement was inhibited by capsaicin, a quinone site tNOX inhibitor specific for tNOX. quinone 110-117 ecto-NOX disulfide-thiol exchanger 2 Homo sapiens 123-127 17379941-5 2006 Because the drug-inhibited ECTO-NOX protein, tNOX was utilized, the enlargement was inhibited by capsaicin, a quinone site tNOX inhibitor specific for tNOX. quinone 110-117 ecto-NOX disulfide-thiol exchanger 2 Homo sapiens 123-127 16428846-1 2006 In atrazine-tolerant tobacco cells with Ser to Thr mutation at the 264th amino acid of PsbA polypeptide in photosystem II (PSII), electron trannsport around the secondary quinone acceptor (Q(B)) site was inhibited to a greater extent by barbatic acid than in wild-type cells. quinone 171-178 psbA Nicotiana tabacum 87-91 16643834-2 2006 Coq2p mediates the conjugation of 4-hydroxybenzoate, the benzoquinone ring precursor, with the completed side chain. quinone 57-69 coenzyme Q2, polyprenyltransferase Homo sapiens 0-5 16475826-8 2006 Ascorbate, glutathione, and 1,4-benzoquinone all reduce ferric TyrH, but much more slowly than tetrahydrobiopterin, suggesting that the pterin is a physiological reductant. quinone 28-44 tyrosine hydroxylase Homo sapiens 63-67 16390130-0 2006 Palladium-catalyzed alkylation of aryl C-H bonds with sp3 organotin reagents using benzoquinone as a crucial promoter. quinone 83-95 Sp3 transcription factor Homo sapiens 54-57 16405730-5 2006 A third patient was found to carry the c.214C>T (p.Arg72Cys) missense mutation in exon 4 of SDHC, which is situated in a highly conserved protein motif that constitutes the quinone-binding site of the succinate: ubiquinone oxidoreductase (SQR) complex in E. coli. quinone 176-183 succinate dehydrogenase complex subunit C Homo sapiens 95-99 17145690-2 2006 Exposure of breast epithelial cells to a redox-cycling and arylating quinone induces mitogen-activated protein kinase phosphorylation of the cytoskeletal filament protein, cytokeratin-8, along with thiol arylation of H3 nuclear histones. quinone 69-76 keratin 8 Homo sapiens 172-185 17145690-4 2006 Immunoaffinity enrichment for low abundance proteins such as ER, coupled with modern mass spectrometry techniques, promises to improve understanding of the protein-modifications produced by endogenous and exogenous quinone exposure and their role in the development or progression of epithelial malignancies such as breast cancer. quinone 215-222 estrogen receptor 1 Homo sapiens 61-63 16883056-4 2006 One such compound, apocynin (4-acetovanillone), is oxidized by peroxidases to yield a variety of oligophenolic and quinone-type compounds that are recognized inhibitors of NADPH oxidase and may be inhibitors of the small G protein Rac1 that controls cell migration. quinone 115-122 Rac family small GTPase 1 Homo sapiens 231-235 15994278-1 2005 NAD(P)H:quinone oxidoreductase 1 (NQO1) plays a dominant role in the reduction of the quinone compound 2,3,5,6-tetramethyl-1,4-benzoquinone (duroquinone, DQ) to durohydroquinone (DQH2) on passage through the rat lung. quinone 8-15 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 34-38 16484134-0 2006 Variability of albumin adducts of 1,4-benzoquinone, a toxic metabolite of benzene, in human volunteers. quinone 34-50 albumin Homo sapiens 15-22 16484134-3 2006 Since high levels of 1,4-BQ-Alb were also measured in unexposed workers from those investigations, the current study was initiated to determine potential sources of 1,4-BQ in the general population. quinone 21-27 albumin Homo sapiens 28-31 16499054-0 2005 [Visible absorption spectra and resonance Raman spectra of n-pi* singlet-triplet transition of p-benzoquinone in CS2]. quinone 95-109 chorionic somatomammotropin hormone 2 Homo sapiens 113-116 16246011-0 2005 Binding sites of lipophilic quinone and quinone analogue inhibitors in the cytochrome b6f complex of oxygenic photosynthesis. quinone 28-35 cytochrome b Chlamydomonas reinhardtii 75-87 16246011-0 2005 Binding sites of lipophilic quinone and quinone analogue inhibitors in the cytochrome b6f complex of oxygenic photosynthesis. quinone 40-47 cytochrome b Chlamydomonas reinhardtii 75-87 16266898-1 2005 BACKGROUND AND OBJECTIVES: The enzyme NAD(P)H:quinone oxidoreductase (NQO1) detoxifies chemicals with quinone rings including benzene metabolites and flavonoids. quinone 46-53 NAD(P)H quinone dehydrogenase 1 Homo sapiens 70-74 16499054-1 2005 The visible absorption spectra of p-benzoquinone (PBQ) in CS2 were measured, and a weak absorption band around 507 nm attributed to n-pi* singlet-triplet transition was denonstrated. quinone 34-48 chorionic somatomammotropin hormone 2 Homo sapiens 58-61 16499054-1 2005 The visible absorption spectra of p-benzoquinone (PBQ) in CS2 were measured, and a weak absorption band around 507 nm attributed to n-pi* singlet-triplet transition was denonstrated. quinone 50-53 chorionic somatomammotropin hormone 2 Homo sapiens 58-61 16382174-6 2005 k(cat) and k(cat)/K(m) values were much smaller for the analogs than for the parent compounds, suggesting that the C13 carbonyl is preferred as a substrate over the quinone. quinone 165-172 homeobox C13 Homo sapiens 115-118 16140270-4 2005 In this study, we show that over-expression of NR1 in human embryonic kidney cells enhances the cytotoxic action of the model quinone, menadione. quinone 126-133 glutamate receptor, ionotropic, NMDA1 (zeta 1) Mus musculus 47-50 16170030-2 2005 Here we report the identification and the characterization of BN82685, a quinone-based CDC25 inhibitor that is active in vitro and in vivo. quinone 73-80 cell division cycle 25C Homo sapiens 87-92 16045903-6 2005 With these substances, therefore, DT-diaphorase both activates and detoxifies the quinone, depending on the target organ. quinone 82-89 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 34-47 16008565-4 2005 The MS and NMR characterizations strongly demonstrate that DA and its analogs inhibit alpha-Syn fibrillization by a mechanism where the oxidation products (quinones) of DA analogs react with the amino groups of alpha-Syn chain, generating alpha-Syn-quinone adducts. quinone 156-163 synuclein alpha Homo sapiens 86-95 16008565-4 2005 The MS and NMR characterizations strongly demonstrate that DA and its analogs inhibit alpha-Syn fibrillization by a mechanism where the oxidation products (quinones) of DA analogs react with the amino groups of alpha-Syn chain, generating alpha-Syn-quinone adducts. quinone 156-163 synuclein alpha Homo sapiens 211-220 16008565-4 2005 The MS and NMR characterizations strongly demonstrate that DA and its analogs inhibit alpha-Syn fibrillization by a mechanism where the oxidation products (quinones) of DA analogs react with the amino groups of alpha-Syn chain, generating alpha-Syn-quinone adducts. quinone 156-163 synuclein alpha Homo sapiens 211-220 16008565-5 2005 It is likely that the amino groups of alpha-Syn undergo nucleophilic attack on the quinone moiety of DA analogs to form imino bonds. quinone 83-90 synuclein alpha Homo sapiens 38-47 15950210-8 2005 This quinone, which is not considered an electrophile, inhibited GAPDH in a time-dependent manner, consistent with irreversible modification and comparable to the electrophilic actions of 1,4-benzoquinone (1,4-BQ). quinone 5-12 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 65-70 15950210-8 2005 This quinone, which is not considered an electrophile, inhibited GAPDH in a time-dependent manner, consistent with irreversible modification and comparable to the electrophilic actions of 1,4-benzoquinone (1,4-BQ). quinone 206-212 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 65-70 16027161-2 2005 Here, we report a new gene designated COQ9 that is also required for the biosynthesis of this lipoid quinone. quinone 101-108 ubiquinone biosynthesis protein COQ9 Saccharomyces cerevisiae S288C 38-42 15983046-5 2005 Ubiquitination of Keap1 is markedly increased in cells exposed to quinone-induced oxidative stress, occurs in parallel with inhibition of Keap1-dependent ubiquitination of Nrf2, and results in decreased steady-state levels of Keap1, particularly in cells that are unable to synthesize glutathione. quinone 66-73 kelch like ECH associated protein 1 Homo sapiens 18-23 15983046-5 2005 Ubiquitination of Keap1 is markedly increased in cells exposed to quinone-induced oxidative stress, occurs in parallel with inhibition of Keap1-dependent ubiquitination of Nrf2, and results in decreased steady-state levels of Keap1, particularly in cells that are unable to synthesize glutathione. quinone 66-73 kelch like ECH associated protein 1 Homo sapiens 138-143 15983046-5 2005 Ubiquitination of Keap1 is markedly increased in cells exposed to quinone-induced oxidative stress, occurs in parallel with inhibition of Keap1-dependent ubiquitination of Nrf2, and results in decreased steady-state levels of Keap1, particularly in cells that are unable to synthesize glutathione. quinone 66-73 NFE2 like bZIP transcription factor 2 Homo sapiens 172-176 15983046-5 2005 Ubiquitination of Keap1 is markedly increased in cells exposed to quinone-induced oxidative stress, occurs in parallel with inhibition of Keap1-dependent ubiquitination of Nrf2, and results in decreased steady-state levels of Keap1, particularly in cells that are unable to synthesize glutathione. quinone 66-73 kelch like ECH associated protein 1 Homo sapiens 138-143 16005845-9 2005 In the catalytic site, the quinone ring is stabilized by Glu-272 of cytochrome b and His-161 of the FeS protein. quinone 27-34 mitochondrially encoded cytochrome b Homo sapiens 68-80 15925494-4 2005 However, reduced glutathione (5 mM), a quinone scavenger, almost completely abolishes the DA effect on mitochondrial complex I and complex IV activities, while tyrosinase (250 units/ml) which catalyses the conversion of DA to quinone products dramatically enhances the former effect. quinone 226-233 tyrosinase Rattus norvegicus 160-170 15950210-4 2005 In a previous study of quinone toxicity, this quinone, whose actions have been exclusively attributed to reactive oxygen species (ROS) generation, caused a reduction in the glycolytic activity of GAPDH under aerobic and anaerobic conditions, indicating indirect and possible direct actions on this enzyme. quinone 23-30 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 196-201 15950210-4 2005 In a previous study of quinone toxicity, this quinone, whose actions have been exclusively attributed to reactive oxygen species (ROS) generation, caused a reduction in the glycolytic activity of GAPDH under aerobic and anaerobic conditions, indicating indirect and possible direct actions on this enzyme. quinone 46-53 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 196-201 15935814-4 2005 Using chicken erythroblast HD3 cells we have shown that exposure to the benzene metabolites catechol, benzoquinone, and hydroquinone leads to increased c-Myb activity, increased phosphorylation of c-Myb and increased production of ROS supporting our hypothesis. quinone 102-114 MYB proto-oncogene, transcription factor Gallus gallus 152-157 17166200-6 2005 In the bone marrow, hydroquinone is oxidized into p-benzoquinone because of the high myeloperoxidase activity. quinone 50-64 myeloperoxidase Homo sapiens 85-100 16036343-0 2005 Enhancement of quinone redox cycling by ascorbate induces a caspase-3 independent cell death in human leukaemia cells. quinone 15-22 caspase 3 Homo sapiens 60-69 15935805-1 2005 We used cysteinyl adducts of serum albumin (Alb) to investigate the production of two reactive benzene metabolites, namely, benzene oxide (BO) and 1,4-benzoquinone (1,4-BQ) in workers exposed to benzene. quinone 147-163 albumin Homo sapiens 44-47 15935812-4 2005 NQO1 catalyzes the detoxication of benzene quinone metabolites and mEH catalyzes the hydrolysis of benzene oxide. quinone 43-50 NAD(P)H dehydrogenase, quinone 1 Mus musculus 0-4 15935814-4 2005 Using chicken erythroblast HD3 cells we have shown that exposure to the benzene metabolites catechol, benzoquinone, and hydroquinone leads to increased c-Myb activity, increased phosphorylation of c-Myb and increased production of ROS supporting our hypothesis. quinone 102-114 MYB proto-oncogene, transcription factor Gallus gallus 197-202 15795063-0 2005 Benzoquinone activates the ERK/MAPK signaling pathway via ROS production in HL-60 cells. quinone 0-12 mitogen-activated protein kinase 1 Homo sapiens 27-30 15795063-8 2005 BQ also produced rapid and prolonged phosphorylation of ERK1/2 proteins. quinone 0-2 mitogen-activated protein kinase 3 Homo sapiens 56-62 15795063-0 2005 Benzoquinone activates the ERK/MAPK signaling pathway via ROS production in HL-60 cells. quinone 0-12 mitogen-activated protein kinase 3 Homo sapiens 31-35 15795063-3 2005 Therefore, we explored the mechanisms underlying BQ-induced HL-60 cell proliferation by studying the role of BQ-induced reactive oxygen species (ROS) in the activation of the ERK-MAPK signaling pathway. quinone 109-111 mitogen-activated protein kinase 1 Homo sapiens 175-178 15795063-9 2005 Simultaneous treatment with catalase or PD98059, a potent MEK protein inhibitor, reduced cell recruitment into the S-phase and also abolished the ERK1/2 protein phosphorylation induced by BQ, suggesting that MEK/ERK is an important pathway involved in BQ-induced ROS mediated proliferation. quinone 188-190 mitogen-activated protein kinase kinase 7 Homo sapiens 58-61 15795063-3 2005 Therefore, we explored the mechanisms underlying BQ-induced HL-60 cell proliferation by studying the role of BQ-induced reactive oxygen species (ROS) in the activation of the ERK-MAPK signaling pathway. quinone 109-111 mitogen-activated protein kinase 3 Homo sapiens 179-183 15795063-9 2005 Simultaneous treatment with catalase or PD98059, a potent MEK protein inhibitor, reduced cell recruitment into the S-phase and also abolished the ERK1/2 protein phosphorylation induced by BQ, suggesting that MEK/ERK is an important pathway involved in BQ-induced ROS mediated proliferation. quinone 188-190 mitogen-activated protein kinase 3 Homo sapiens 146-152 15795063-9 2005 Simultaneous treatment with catalase or PD98059, a potent MEK protein inhibitor, reduced cell recruitment into the S-phase and also abolished the ERK1/2 protein phosphorylation induced by BQ, suggesting that MEK/ERK is an important pathway involved in BQ-induced ROS mediated proliferation. quinone 188-190 mitogen-activated protein kinase kinase 7 Homo sapiens 208-211 15867239-1 2005 PURPOSE: 17-(Allylamino)-17-demethoxygeldanamycin (17AAG), a benzoquinone antibiotic, down-regulates oncoproteins by binding specifically to heat shock protein 90 (HSP90). quinone 61-73 heat shock protein 90 alpha family class A member 1 Homo sapiens 141-162 15795063-9 2005 Simultaneous treatment with catalase or PD98059, a potent MEK protein inhibitor, reduced cell recruitment into the S-phase and also abolished the ERK1/2 protein phosphorylation induced by BQ, suggesting that MEK/ERK is an important pathway involved in BQ-induced ROS mediated proliferation. quinone 188-190 mitogen-activated protein kinase 1 Homo sapiens 146-149 15795063-9 2005 Simultaneous treatment with catalase or PD98059, a potent MEK protein inhibitor, reduced cell recruitment into the S-phase and also abolished the ERK1/2 protein phosphorylation induced by BQ, suggesting that MEK/ERK is an important pathway involved in BQ-induced ROS mediated proliferation. quinone 252-254 mitogen-activated protein kinase kinase 7 Homo sapiens 208-211 15867391-5 2005 Indeed, COMPARE analysis within the National Cancer Institute database revealed a number of chemically related quinone derivatives that could potentially react with sulfur nucleophiles in a similar manner and suggested that thioredoxin/thioredoxin reductase signal transduction could be a putative target. quinone 111-118 thioredoxin Homo sapiens 224-235 15867391-5 2005 Indeed, COMPARE analysis within the National Cancer Institute database revealed a number of chemically related quinone derivatives that could potentially react with sulfur nucleophiles in a similar manner and suggested that thioredoxin/thioredoxin reductase signal transduction could be a putative target. quinone 111-118 peroxiredoxin 5 Homo sapiens 236-257 15867239-1 2005 PURPOSE: 17-(Allylamino)-17-demethoxygeldanamycin (17AAG), a benzoquinone antibiotic, down-regulates oncoproteins by binding specifically to heat shock protein 90 (HSP90). quinone 61-73 heat shock protein 90 alpha family class A member 1 Homo sapiens 164-169 15878501-2 2005 All compounds that can undergo oxidation to the corresponding quinone demonstrated inhibition of FDrv210C cells and Baf/ERX cells. quinone 62-69 BAF nuclear assembly factor 1 Homo sapiens 116-119 15746574-1 2005 The elevated expression of the flavoprotein NAD(P)H:quinone acceptor oxidoreductase (NQO1) (EC 1.6.99.2) in many human solid tumors, along with its ability to activate quinone-based anticancer agents, makes it an excellent target for enzyme-directed drug development. quinone 52-59 NAD(P)H quinone dehydrogenase 1 Homo sapiens 85-89 15819723-4 2005 NAC rescued cell growth that was suppressed by heat shock protein (Hsp) 90 inhibitors possibly by chemical modification of their quinone moiety. quinone 129-136 heat shock protein 90 alpha family class A member 1 Rattus norvegicus 47-74 15629867-1 2005 9,10-Phenanthraquinone (PQ), a major quinone contained in diesel exhaust particles and atmospheric PM(2.5), undergoes one-electron reduction by flavin enzymes such as NADPH-cytochrome P450 reductase, leading to production of reactive oxygen species in vitro. quinone 15-22 cytochrome p450 oxidoreductase Homo sapiens 167-198 15612812-8 2004 These results strongly suggest that the quinone of protocatechuic acid and its analogues undergo a nucleophilic attack at C-2 to yield 2-substituted-3,4-diols. quinone 40-47 complement C2 Homo sapiens 122-125 15652497-0 2005 Quinone-induced Cdc25A inhibition causes ERK-dependent connexin phosphorylation. quinone 0-7 cell division cycle 25A Homo sapiens 16-22 15652497-0 2005 Quinone-induced Cdc25A inhibition causes ERK-dependent connexin phosphorylation. quinone 0-7 mitogen-activated protein kinase 1 Homo sapiens 41-44 15525690-2 2005 The present study is aimed to determine whether increased protein stability is a mechanism by which quinone compounds, like tert-butylhydroquinone (tBHQ), may enhance Nrf2-mediated transcriptional activation and subsequent antioxidant protection. quinone 100-107 NFE2 like bZIP transcription factor 2 Homo sapiens 167-171 15582818-1 2005 A weak visible absorption spectrum of p-benzoquinone (p-BQ) in CS2 due to n-pi* singlet-triplet transition was measured. quinone 38-52 chorionic somatomammotropin hormone 2 Homo sapiens 63-66 15582818-1 2005 A weak visible absorption spectrum of p-benzoquinone (p-BQ) in CS2 due to n-pi* singlet-triplet transition was measured. quinone 54-58 chorionic somatomammotropin hormone 2 Homo sapiens 63-66 15607759-10 2004 Specific glutathione-conjugates of the estrogen quinone also potently inhibited hGSTM1-1 and hGSTA1-1. quinone 48-55 glutathione S-transferase mu 1 Homo sapiens 80-88 15607759-10 2004 Specific glutathione-conjugates of the estrogen quinone also potently inhibited hGSTM1-1 and hGSTA1-1. quinone 48-55 glutathione S-transferase alpha 1 Homo sapiens 93-101 15572695-5 2004 Keap1-dependent ubiquitination of Nrf2 is inhibited following exposure of cells to quinone-induced oxidative stress and sulforaphane, a cancer-preventive isothiocyanate. quinone 83-90 kelch like ECH associated protein 1 Homo sapiens 0-5 15572695-5 2004 Keap1-dependent ubiquitination of Nrf2 is inhibited following exposure of cells to quinone-induced oxidative stress and sulforaphane, a cancer-preventive isothiocyanate. quinone 83-90 NFE2 like bZIP transcription factor 2 Homo sapiens 34-38 15572695-6 2004 A mutant Keap1 protein containing a single cysteine-to-serine substitution at residue 151 within the BTB domain of Keap1 is markedly resistant to inhibition by either quinone-induced oxidative stress or sulforaphane. quinone 167-174 kelch like ECH associated protein 1 Homo sapiens 9-14 15572695-6 2004 A mutant Keap1 protein containing a single cysteine-to-serine substitution at residue 151 within the BTB domain of Keap1 is markedly resistant to inhibition by either quinone-induced oxidative stress or sulforaphane. quinone 167-174 kelch like ECH associated protein 1 Homo sapiens 115-120 15514562-6 2004 Although the relationship is not perfect, the ability of TT analogs to induce caspase-3, -8 and -9 activities may be linked to their quinone functionality and cytotoxicity. quinone 133-140 caspase 3 Homo sapiens 78-98 15269213-6 2004 Here we show that complexes I and II differ in their ability to use the quinone pool in clk-1. quinone 72-79 5-demethoxyubiquinone hydroxylase, mitochondrial Caenorhabditis elegans 88-93 15350128-5 2004 K562 cells with QR2 expression suppressed by RNAi showed similar properties as resveratrol-treated cells in their resistance to quinone toxicity. quinone 128-135 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 16-19 15337166-7 2004 Furthermore, BQ and HQ inhibited the in vitro caspase-3 activation, suggesting that the inhibition of caspase-3 activation due to ROS produced by BQ- and HQ-treatment was related to the suppression of apoptosis. quinone 13-15 caspase 3 Homo sapiens 46-55 15326287-0 2004 Identification of a quinone-sensitive redox switch in the ArcB sensor kinase. quinone 20-27 hypothetical protein Escherichia coli 58-62 15326287-3 2004 Under aerobic conditions, the kinase activity of ArcB is inhibited by the quinone electron carriers that act as direct negative signals. quinone 74-81 hypothetical protein Escherichia coli 49-53 15288807-1 2004 Here, we report the identification and characterization of five ortho-quinone inhibitors of PTPalpha. quinone 70-77 protein phosphatase 2 protein activator Mus musculus 92-100 15377160-6 2004 Similarly, GSTP1 yielded two conjugates, 2-OHE(2)-1-SG and 2-OHE(2)-4-SG, from the corresponding quinone 2-hydroxyestradiol-quinone and one conjugate, 4-OHE(2)-2-SG, from 4-hydroxyestradiol-quinone. quinone 97-104 glutathione S-transferase pi 1 Homo sapiens 11-16 15319341-2 2004 The cytochrome P450 (P450)-derived catechol and quinone metabolites of etoposide may be important in the damage to the MLL (mixed lineage leukemia) gene and other genes resulting in leukemia-associated chromosomal translocations. quinone 48-55 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 15-19 15319341-2 2004 The cytochrome P450 (P450)-derived catechol and quinone metabolites of etoposide may be important in the damage to the MLL (mixed lineage leukemia) gene and other genes resulting in leukemia-associated chromosomal translocations. quinone 48-55 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 21-25 15319341-2 2004 The cytochrome P450 (P450)-derived catechol and quinone metabolites of etoposide may be important in the damage to the MLL (mixed lineage leukemia) gene and other genes resulting in leukemia-associated chromosomal translocations. quinone 48-55 lysine methyltransferase 2A Homo sapiens 119-122 15273299-2 2004 The mechanisms of reduction of the orthoquinone cofactor (PQQ) of MDH and sGDH involve concerted base-catalyzed proton abstraction from the hydroxyl moiety of methanol or from the 1-hydroxyl of glucose, and hydride equivalent transfer from the substrate to the quinone carbonyl carbon C5 of PQQ. quinone 40-47 NADH:ubiquinone oxidoreductase subunit B5 Homo sapiens 74-78 15337166-7 2004 Furthermore, BQ and HQ inhibited the in vitro caspase-3 activation, suggesting that the inhibition of caspase-3 activation due to ROS produced by BQ- and HQ-treatment was related to the suppression of apoptosis. quinone 13-15 caspase 3 Homo sapiens 102-111 15337166-7 2004 Furthermore, BQ and HQ inhibited the in vitro caspase-3 activation, suggesting that the inhibition of caspase-3 activation due to ROS produced by BQ- and HQ-treatment was related to the suppression of apoptosis. quinone 146-148 caspase 3 Homo sapiens 46-55 15337166-7 2004 Furthermore, BQ and HQ inhibited the in vitro caspase-3 activation, suggesting that the inhibition of caspase-3 activation due to ROS produced by BQ- and HQ-treatment was related to the suppression of apoptosis. quinone 146-148 caspase 3 Homo sapiens 102-111 15520498-12 2004 Superoxide dismutase, catalase and glutathione peroxidase must be considered as a part of the intracellular antioxidant defense mechanism of Hep G2 cells against single electron reducing quinone-containing anticancer antibiotics. quinone 187-194 catalase Homo sapiens 22-30 14993213-1 2004 Previous electron microscopic studies of bacterial RCLH1 complexes demonstrated both circular and elliptical conformations of the LH1 ring, and this implied flexibility has been suggested to allow passage of quinol from the Q(B) site of the RC to the quinone pool prior to reduction of the cytochrome bc(1) complex. quinone 251-258 procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 Homo sapiens 53-56 15202892-3 2004 In particular, the quinone-containing antibiotics geldanamycin (GDA) and herbimycin A inhibit Hsp90 function in vitro at low micromolar concentrations via interaction with an ATP binding domain. quinone 19-26 heat shock protein 90 alpha family class A member 1 Homo sapiens 94-99 15155853-6 2004 The pBQ-C/APE1 complex, generated by MD, has a similar hydrogen bond network between target phosphodiester bond at the pBQ-C site and key amino acids at the active site, as in the crystallographically determined APE1 complexed with an AP site-containing DNA duplex. quinone 4-7 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 10-14 15155853-6 2004 The pBQ-C/APE1 complex, generated by MD, has a similar hydrogen bond network between target phosphodiester bond at the pBQ-C site and key amino acids at the active site, as in the crystallographically determined APE1 complexed with an AP site-containing DNA duplex. quinone 4-7 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 212-216 14976336-0 2004 Human CD34+ hematopoietic progenitor cells are sensitive targets for toxicity induced by 1,4-benzoquinone. quinone 89-105 CD34 molecule Homo sapiens 6-10 15131056-1 2004 PURPOSE: The purpose of our study was to develop and validate an isogenic cell line pair that differs only in the expression of NAD(P)H:quinone oxidoreductase (NQO1) that can be used to examine the in vitro and in vivo role of NQO1 in the bioactivation of the antitumor quinone RH1 (2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone), a compound currently in Phase I clinical trials. quinone 136-143 NAD(P)H quinone dehydrogenase 1 Homo sapiens 160-164 15134917-2 2004 In 10% methanol/water, the one-electron reduction of quinones L1 and L2 to the corresponding semiquinones is shifted to more positive potentials upon addition of one equivalent of Zn(II), Ni(II), Co(II) or Cd(II) and is consistent with formation of a 1:1 complex involving the quinone(N) and adjacent quinone(O). quinone 53-60 mitochondrially encoded cytochrome c oxidase II Homo sapiens 196-202 15134917-2 2004 In 10% methanol/water, the one-electron reduction of quinones L1 and L2 to the corresponding semiquinones is shifted to more positive potentials upon addition of one equivalent of Zn(II), Ni(II), Co(II) or Cd(II) and is consistent with formation of a 1:1 complex involving the quinone(N) and adjacent quinone(O). quinone 97-104 mitochondrially encoded cytochrome c oxidase II Homo sapiens 196-202 15028260-5 2004 For simple substituents R(2) at the quinoline 2-position, the rates of quinone metabolism by hNQO1 decrease for R(2)=Cl>H approximately Me>Ph. quinone 71-78 NAD(P)H quinone dehydrogenase 1 Homo sapiens 93-98 14976336-7 2004 A significant increase in the percentage of micronucleated CD34(+) cells was detected in cultures treated with 1,4-BQ. quinone 111-117 CD34 molecule Homo sapiens 59-63 14976336-8 2004 In addition, the p21 mRNA level was elevated in 1,4-BQ-treated cells, suggesting that human CD34(+) cells utilize the p53 pathway in response to 1,4-BQ-induced DNA damage. quinone 48-54 H3 histone pseudogene 16 Homo sapiens 17-20 14976336-8 2004 In addition, the p21 mRNA level was elevated in 1,4-BQ-treated cells, suggesting that human CD34(+) cells utilize the p53 pathway in response to 1,4-BQ-induced DNA damage. quinone 48-54 CD34 molecule Homo sapiens 92-96 14976336-8 2004 In addition, the p21 mRNA level was elevated in 1,4-BQ-treated cells, suggesting that human CD34(+) cells utilize the p53 pathway in response to 1,4-BQ-induced DNA damage. quinone 48-54 tumor protein p53 Homo sapiens 118-121 14976336-8 2004 In addition, the p21 mRNA level was elevated in 1,4-BQ-treated cells, suggesting that human CD34(+) cells utilize the p53 pathway in response to 1,4-BQ-induced DNA damage. quinone 145-151 H3 histone pseudogene 16 Homo sapiens 17-20 14976336-8 2004 In addition, the p21 mRNA level was elevated in 1,4-BQ-treated cells, suggesting that human CD34(+) cells utilize the p53 pathway in response to 1,4-BQ-induced DNA damage. quinone 145-151 CD34 molecule Homo sapiens 92-96 14976336-8 2004 In addition, the p21 mRNA level was elevated in 1,4-BQ-treated cells, suggesting that human CD34(+) cells utilize the p53 pathway in response to 1,4-BQ-induced DNA damage. quinone 145-151 tumor protein p53 Homo sapiens 118-121 14976336-11 2004 These results show that human CD34(+) cells are sensitive targets for 1,4-BQ toxicity that use the p53 DNA damage response pathway in response to genotoxic stress. quinone 70-76 CD34 molecule Homo sapiens 30-34 14976336-11 2004 These results show that human CD34(+) cells are sensitive targets for 1,4-BQ toxicity that use the p53 DNA damage response pathway in response to genotoxic stress. quinone 70-76 tumor protein p53 Homo sapiens 99-102 14718602-3 2004 We evaluated >10,000 compounds for inhibition of human Cdc25 phosphatases and identified many potent and selective inhibitors, which all contained a quinone. quinone 152-159 cell division cycle 25C Homo sapiens 58-63 14672930-5 2004 Mutation of Sdh3p His-46 or His-113 leads to a marked reduction in the catalytic efficiency of the enzyme for quinone reduction, suggesting that these residues form part of a quinone-binding site. quinone 110-117 succinate dehydrogenase cytochrome b subunit SDH3 Saccharomyces cerevisiae S288C 12-17 15010841-1 2004 NQO1 is a cytosolic flavoprotein that plays a dual role in the detoxification of potentially carcinogenic compounds and the bioreductive activation of quinone based anticancer drugs. quinone 151-158 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-4 14640977-0 2004 Alternative quinone substrates and inhibitors of human electron-transfer flavoprotein-ubiquinone oxidoreductase. quinone 12-19 thioredoxin reductase 1 Homo sapiens 97-111 14640977-9 2004 The observation of simple Michaelis-Menten kinetic patterns and a single type of quinone-binding site, determined by fluorescence titrations of the protein with DBMIB and 6-(10-bromodecyl)ubiquinone, are consistent with one ubiquinone-binding site per ETF-QO monomer. quinone 81-88 electron transfer flavoprotein dehydrogenase Homo sapiens 252-258 14614574-0 2004 Structure-activity study with bioreductive benzoquinone alkylating agents: effects on DT-diaphorase-mediated DNA crosslink and strand break formation in relation to mechanisms of cytotoxicity. quinone 43-55 NAD(P)H quinone dehydrogenase 1 Homo sapiens 86-99 14614574-2 2004 The specific objectives were: (1) to investigate the effects of functional group substitutions to the benzoquinone ring on DNA crosslink and strand break formation subsequent to reduction of the analogs by DT-diaphorase (DTD) in vitro, (2) to correlate DNA crosslink and strand break formation by the analogs with anaerobic reduction of the BM analogs by DTD and their redox cycling in vitro, and (3) to correlate DNA crosslink and strand break formation by the BM analogs with their cytotoxic effects in cancer cells. quinone 102-114 NAD(P)H quinone dehydrogenase 1 Homo sapiens 206-219 15012118-2 2004 The stereochemistry was determined to be syn in the reaction catalyzed by a dicationic palladium(II) catalyst generated from Pd(MeCN)4(BF4)2 and (S,S)-ip-boxax in the presence of benzoquinone in methanol, while it is mainly anti in the reaction catalyzed by PdCl2(MeCN)2 in the presence of a chloride ion. quinone 179-191 synemin Homo sapiens 41-44 15012118-2 2004 The stereochemistry was determined to be syn in the reaction catalyzed by a dicationic palladium(II) catalyst generated from Pd(MeCN)4(BF4)2 and (S,S)-ip-boxax in the presence of benzoquinone in methanol, while it is mainly anti in the reaction catalyzed by PdCl2(MeCN)2 in the presence of a chloride ion. quinone 179-191 phosducin like 2 Homo sapiens 258-270 14672929-9 2004 Functionally important residues identified by mutagenesis of the SDH3 and SDH4 genes are located near the two proposed quinone-binding sites, which are separated by the heme. quinone 119-126 succinate dehydrogenase cytochrome b subunit SDH3 Saccharomyces cerevisiae S288C 65-69 14672929-9 2004 Functionally important residues identified by mutagenesis of the SDH3 and SDH4 genes are located near the two proposed quinone-binding sites, which are separated by the heme. quinone 119-126 succinate dehydrogenase membrane anchor subunit SDH4 Saccharomyces cerevisiae S288C 74-78 14672930-5 2004 Mutation of Sdh3p His-46 or His-113 leads to a marked reduction in the catalytic efficiency of the enzyme for quinone reduction, suggesting that these residues form part of a quinone-binding site. quinone 175-182 succinate dehydrogenase cytochrome b subunit SDH3 Saccharomyces cerevisiae S288C 12-17 14961113-2 2004 This includes the intensely studied cytochrome bc1, which catalyses electron transfer between quinone and cytochrome c. quinone 94-101 cytochrome c, somatic Homo sapiens 106-118 14967060-1 2004 Copper amine oxidases (CAOs) and lysyl oxidase (LOX) both contain Cu(2+) and quinone cofactors that are derived from a tyrosine residue in the active site. quinone 77-84 lysyl oxidase Homo sapiens 33-46 14610226-7 2004 Moreover, treatment of hepatocytes with the redox cycling quinone menadione resulted in overexpression of CYP2A5 and GSTM1 mRNA. quinone 58-65 cytochrome P450, family 2, subfamily a, polypeptide 5 Mus musculus 106-112 14610226-7 2004 Moreover, treatment of hepatocytes with the redox cycling quinone menadione resulted in overexpression of CYP2A5 and GSTM1 mRNA. quinone 58-65 glutathione S-transferase, mu 1 Mus musculus 117-122 14967060-1 2004 Copper amine oxidases (CAOs) and lysyl oxidase (LOX) both contain Cu(2+) and quinone cofactors that are derived from a tyrosine residue in the active site. quinone 77-84 lysyl oxidase Homo sapiens 48-51 14604985-5 2004 Compared with other related pyridine nucleotide-disulfide oxidoreductases such as glutathione reductase or trypanothione reductase, the k(ca)(t)/K(m) value for quinone reduction by TrxR was about 1 order of magnitude higher, and it was not directly related to the one-electron reduction potential of the quinones. quinone 160-167 glutathione-disulfide reductase Homo sapiens 82-103 14726156-5 2004 The presence of bovine serum albumin (BSA) in the incubation mixture protects DT-diaphorase against the inactivation by tetrachloro-p-benzoquinone, probably by interacting with the quinone. quinone 139-146 albumin Rattus norvegicus 23-36 14726156-5 2004 The presence of bovine serum albumin (BSA) in the incubation mixture protects DT-diaphorase against the inactivation by tetrachloro-p-benzoquinone, probably by interacting with the quinone. quinone 139-146 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 78-91 14659977-1 2004 Effects of tanshinone IIA, an active diterpene quinone of the herbal medicine Salvia miltiorrhiza (Danshen), on cytochrome P450 (CYP), UDP-glucuronosyl transferase (UGT), and glutathione S-transferase (GST) were studied in the arylhydrocarbon (Ah)-responsive C57BL/6J (B6) and nonresponsive DBA/2J (D2) mice. quinone 47-54 ATPase, class II, type 9A Mus musculus 22-25 14974709-7 2004 It is seen that for both the quinone-ArA and quinone-AlA systems, the kq values initially increase and then get saturated at some diffusion-controlled limiting values (kqDC) as deltaG0 values gradually become more negative. quinone 29-36 ATP binding cassette subfamily C member 6 Homo sapiens 37-40 14974709-10 2004 Present results have been rationalized based on the assumption that an orientational restriction is imposed for the encounter complexes in quinone-AlA systems to undergo ET reactions, which arises because of the localized (at amino nitrogen) shapes of the highest-occupied molecular orbitals (HOMO) of AlA in comparison to the pi-like HOMO of the ArA. quinone 139-146 ATP binding cassette subfamily C member 6 Homo sapiens 347-350 14677970-5 2003 A study of DNA alkylation by the first C-6,C-7-unsubstituted aziridinomitosene 11a has been carried out, and evidence for DNA cross-link formation involving nucleophilic addition to the quinone subunit is described. quinone 186-193 complement C6 Homo sapiens 39-42 14677970-5 2003 A study of DNA alkylation by the first C-6,C-7-unsubstituted aziridinomitosene 11a has been carried out, and evidence for DNA cross-link formation involving nucleophilic addition to the quinone subunit is described. quinone 186-193 complement C7 Homo sapiens 43-46 14530273-0 2003 Reproductive fitness and quinone content of Caenorhabditis elegans clk-1 mutants fed coenzyme Q isoforms of varying length. quinone 25-32 5-demethoxyubiquinone hydroxylase, mitochondrial Caenorhabditis elegans 67-72 14654717-6 2003 The utilization of K1 and MK-4 in various tissues was estimated by calculating the ratios between accumulated quinone and epoxide species. quinone 110-117 keratin 1 Rattus norvegicus 19-30 14563485-1 2003 L-Deprenyl, an inhibitor of mitochondrial monoamine oxidase B (MAO B), inhibits the swelling of liver mitochondria induced by the pro-oxidant 2-methyl-1,4-naphtoquinone with a K(i) dependent on quinone concentration. quinone 161-168 monoamine oxidase B Homo sapiens 42-61 14563485-1 2003 L-Deprenyl, an inhibitor of mitochondrial monoamine oxidase B (MAO B), inhibits the swelling of liver mitochondria induced by the pro-oxidant 2-methyl-1,4-naphtoquinone with a K(i) dependent on quinone concentration. quinone 161-168 monoamine oxidase B Homo sapiens 63-68 12874275-8 2003 In summary, EGFR-dependent signaling was mediated by protein-tyrosine phosphatase inactivation (menadione), GSH depletion (BQ), and redox-cycling (DMNQ), funneling into the same signaling pathway. quinone 123-125 epidermal growth factor receptor Rattus norvegicus 12-16 12815004-1 2003 Phase II detoxifying enzymes like NAD(P)H (quinone acceptor)oxidoreductase1 (NQO1), glutathione S-transferases (GST), and UDP-glucuronyltransferases (UGT) may play an important role in preventing carcinogen-induced cancers. quinone 43-50 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 77-81 14511124-2 2003 Although such quinone derivatives are usually produced via the autoxidation of catecholamines, tyrosinase, which is a key enzyme in melanin biosynthesis via the production of DOPA and subsequent molecules, may potentially accelerate the induction of catecholamine quinone derivatives by its oxidase activity. quinone 14-21 tyrosinase Homo sapiens 95-105 12920209-1 2003 The specific involvement of NAD(P)H:quinone oxidoreductase 1 (NQO1) in the bioactivation of quinone prodrugs has been shown through the use of the inhibitor of NQO1, dicoumarol. quinone 36-43 NAD(P)H quinone dehydrogenase 1 Homo sapiens 62-66 12920209-1 2003 The specific involvement of NAD(P)H:quinone oxidoreductase 1 (NQO1) in the bioactivation of quinone prodrugs has been shown through the use of the inhibitor of NQO1, dicoumarol. quinone 36-43 NAD(P)H quinone dehydrogenase 1 Homo sapiens 160-164 12874275-0 2003 Epidermal growth factor receptor is a common mediator of quinone-induced signaling leading to phosphorylation of connexin-43: role of glutathione and tyrosine phosphatases. quinone 57-64 epidermal growth factor receptor Rattus norvegicus 0-32 12874275-0 2003 Epidermal growth factor receptor is a common mediator of quinone-induced signaling leading to phosphorylation of connexin-43: role of glutathione and tyrosine phosphatases. quinone 57-64 gap junction protein, alpha 1 Rattus norvegicus 113-124 12874275-6 2003 The mere depletion of GSH by application of diethyl maleate EGFR-dependently activated ERK and Akt, thus mimicking BQ effects. quinone 115-117 epidermal growth factor receptor Rattus norvegicus 60-64 12950262-7 2003 Unlike higher plant mitochondrial alternative oxidases, to which PTOX shows sequence similarity (but also differences, especially in a putative quinone binding site and in cysteine conservation), PTOX activity does not appear to be regulated by pyruvate or any other tested sugar, nor by AMP. quinone 144-151 Alternative oxidase family protein Arabidopsis thaliana 65-69 12950262-9 2003 Various quinone analogues were tested for their inhibitory activity on PTOX. quinone 8-15 Alternative oxidase family protein Arabidopsis thaliana 71-75 12899636-6 2003 This indicates that no further proteins are required for electron transfer between the quinone pool and fumarate if we assume direct reduction of CymA by quinols. quinone 87-94 cytochrome c Shewanella oneidensis MR-1 146-150 12862476-6 2003 2002, 124, 6349-6356] to give pK(R) = -9.6 as the Lewis acidity constant of O-protonated p-quinone methide. quinone 89-98 pyruvate kinase L/R Homo sapiens 30-35 12862476-7 2003 Values of pK(R) = 2.3 for the Lewis acidity constant of neutral p-quinone methide and pK(add) = -7.6 for the overall addition of solvent water to p-quinone methide to form 4-hydroxybenzyl alcohol are also reported. quinone 66-73 prokineticin receptor 2 Homo sapiens 10-19 12862476-7 2003 Values of pK(R) = 2.3 for the Lewis acidity constant of neutral p-quinone methide and pK(add) = -7.6 for the overall addition of solvent water to p-quinone methide to form 4-hydroxybenzyl alcohol are also reported. quinone 64-73 prokineticin receptor 2 Homo sapiens 10-19 12649308-1 2003 The bioreductive activation of the antitumor quinone mitomycin C (MMC) by NAD(P)H: quinone oxidoreductase 1 (NQO1) is complicated by the ability of MMC to also act as a mechanism-based inhibitor of NQO1 in a pH dependent manner. quinone 45-52 NAD(P)H dehydrogenase, quinone 1 Mus musculus 74-107 12649308-1 2003 The bioreductive activation of the antitumor quinone mitomycin C (MMC) by NAD(P)H: quinone oxidoreductase 1 (NQO1) is complicated by the ability of MMC to also act as a mechanism-based inhibitor of NQO1 in a pH dependent manner. quinone 45-52 NAD(P)H dehydrogenase, quinone 1 Mus musculus 109-113 12649308-1 2003 The bioreductive activation of the antitumor quinone mitomycin C (MMC) by NAD(P)H: quinone oxidoreductase 1 (NQO1) is complicated by the ability of MMC to also act as a mechanism-based inhibitor of NQO1 in a pH dependent manner. quinone 45-52 NAD(P)H dehydrogenase, quinone 1 Mus musculus 198-202 12686490-8 2003 Nevertheless, the results of the present study indicate that quinone-type oxidation products of quercetin likely act as specific active site inhibitors of GSTP1-1 by binding to cysteine 47. quinone 61-68 glutathione S-transferase pi 1 Homo sapiens 155-162 12851037-0 2003 Diterpene quinone tanshinone IIA selectively inhibits mouse and human cytochrome p4501A2. quinone 10-17 ATPase, class II, type 9A Mus musculus 29-32 12851037-2 2003 Tanshinone IIA is the main active diterpene quinone in the herbal medicine Salvia miltiorrhiza. quinone 44-51 ATPase, class II, type 9A Mus musculus 11-14 12768337-9 2003 Both cytosolic and membrane-bound dicumarol-sensitive NAD(P)H:(quinone acceptor) oxidoreductase (DT-diaphorase, EC 1.6.99.2) activities were decreased by diets supplemented with CoQ(10). quinone 63-70 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 97-110 12679191-3 2003 DT-diaphorase is a detoxifying enzyme for quinone-containing substances, due to its ability to prevent their one-electron reduction and the consequent generation of reactive oxygen species (ROS). quinone 42-49 NAD(P)H dehydrogenase [quinone] 1 Cavia porcellus 0-13 12755589-10 2003 Cytochrome c is adducted in vitro with benzoquinone, an electrophilic metabolite of benzene capable of interacting with nucleophilic sites within proteins. quinone 39-51 cytochrome c Sus scrofa 0-12 12680784-7 2003 Thus, we conclude that an electrophilic quinone oxidation product that reacts with intracellular nucleophiles including protein thiol or GSH plays a major role in the GSTP1 gene expression. quinone 40-47 glutathione S-transferase pi 1 Homo sapiens 167-172 12663042-1 2003 The metabolic activation of a variety of quinone-based anticancer agents occurs, in part, as a result of the bioreductive activation by the flavoprotein NAD(P)H:quinone-acceptor oxidoreductase (NQO1) (EC 1.6.99.2). quinone 41-48 NAD(P)H quinone dehydrogenase 1 Homo sapiens 194-198 12686136-1 2003 Lysyl oxidase (LOX) and four lysyl oxidase-like proteins, LOXL, LOXL2, LOXL3 and LOXL4, each contain a copper binding site, conserved lysyl and tyrosyl residues that may contribute to quinone co-factor formation, and a cytokine receptor-like domain. quinone 184-191 Lysyl oxidase-like 1 Drosophila melanogaster 0-13 12686136-1 2003 Lysyl oxidase (LOX) and four lysyl oxidase-like proteins, LOXL, LOXL2, LOXL3 and LOXL4, each contain a copper binding site, conserved lysyl and tyrosyl residues that may contribute to quinone co-factor formation, and a cytokine receptor-like domain. quinone 184-191 Lysyl oxidase-like 1 Drosophila melanogaster 15-18 12686136-1 2003 Lysyl oxidase (LOX) and four lysyl oxidase-like proteins, LOXL, LOXL2, LOXL3 and LOXL4, each contain a copper binding site, conserved lysyl and tyrosyl residues that may contribute to quinone co-factor formation, and a cytokine receptor-like domain. quinone 184-191 Lysyl oxidase-like 1 Drosophila melanogaster 29-42 12553801-1 2003 Novel Cu(I) complexes containing a mu2-eta2,eta2-type benzoquinone ligand have been synthesized and crystallographycally characterized. quinone 54-66 DNA polymerase iota Homo sapiens 39-43 12590933-5 2003 Ninety percent of H(2)O(2) generation by both the quinones can be prevented by dicumarol, an inhibitor of NAD(P)H quinone oxidoreductase (NQO1), at the submicromolar level, regardless of the quinone concentrations. quinone 50-57 NAD(P)H quinone dehydrogenase 1 Homo sapiens 138-142 12590933-9 2003 Finally, we show evidence that ROS production is a consequence of the compensatory defensive role of NQO1 against quinone arylation. quinone 114-121 NAD(P)H quinone dehydrogenase 1 Homo sapiens 101-105 12565167-3 2003 The constitutive ECTO-NOX (CNOX), is hormone responsive and refractory to quinone-site inhibitors. quinone 74-81 ecto-NOX disulfide-thiol exchanger 1 Homo sapiens 4-25 12565167-3 2003 The constitutive ECTO-NOX (CNOX), is hormone responsive and refractory to quinone-site inhibitors. quinone 74-81 ecto-NOX disulfide-thiol exchanger 1 Homo sapiens 27-31 12565167-4 2003 A tumor-associated NOX (tNOX) is unregulated, refractory to hormones and growth factors and responds to quinone-site inhibitors. quinone 104-111 ecto-NOX disulfide-thiol exchanger 2 Homo sapiens 24-28 12588957-1 2003 NAD(P)H:quinone oxidoreductase 1 (NQO1; DT-diaphorase; DTD) is a cytosolic two-electron reductase, and compounds of the quinone family such as mitomycin C are efficiently bioactivated by this enzyme. quinone 8-15 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 12588957-1 2003 NAD(P)H:quinone oxidoreductase 1 (NQO1; DT-diaphorase; DTD) is a cytosolic two-electron reductase, and compounds of the quinone family such as mitomycin C are efficiently bioactivated by this enzyme. quinone 8-15 NAD(P)H quinone dehydrogenase 1 Homo sapiens 40-53 12553801-1 2003 Novel Cu(I) complexes containing a mu2-eta2,eta2-type benzoquinone ligand have been synthesized and crystallographycally characterized. quinone 54-66 DNA polymerase iota Homo sapiens 44-48 12553814-1 2003 This communication reports the SERS observation of p-benzosemiquinone radical anion, produced on reduction of p-benzoquinone by Ag nanoparticles at the metal-water interface. quinone 110-124 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 31-35 12027671-10 2002 The transformation of p-quinone 2 into acetophenone 3 might contribute to the chemistry of tocopherols oxidized at C-4, i.e., 4-hydroxy-alpha-tocopherol and 4-oxo-alpha-tocopherol, which have been proposed as precursors of natural vitamin E metabolites. quinone 22-31 complement C4A (Rodgers blood group) Homo sapiens 115-118 12429349-4 2002 This panel of cell lines, allowed investigation of the protective role of NQO1 in quinone cytotoxicity. quinone 82-89 NAD(P)H dehydrogenase [quinone] 1 Cricetulus griseus 74-78 12099462-2 2002 Although numerous addition reactions of thiolated alkane and aromatic compounds to quinones have been previously reported, this study indicates that inorganic forms of S(-II) act as nucleophiles and electrophiles in addition reactions to the alpha,beta-conjugated system of the quinone. quinone 83-90 transcription elongation factor A1 Homo sapiens 168-173 12049845-5 2002 SOD inhibits Cyt(III)c reduction rates in the presence of these quinones and X/XO in a manner which is also dependent on the quinone half-wave redox potential. quinone 64-71 superoxide dismutase 1 Homo sapiens 0-3 12626122-7 2003 In addition, this quinone activated p38 only at lower concentrations; high concentrations inhibited p38 activity. quinone 18-25 mitogen-activated protein kinase 14 Homo sapiens 36-39 12626122-7 2003 In addition, this quinone activated p38 only at lower concentrations; high concentrations inhibited p38 activity. quinone 18-25 mitogen-activated protein kinase 14 Homo sapiens 100-103 12534287-12 2003 These results suggest that the ND5 subunit is involved in construction of the inhibitor- and quinone-binding site(s). quinone 93-100 NADH dehydrogenase subunit 5 Bos taurus 31-34 12385719-6 2002 Of the quinone adducts, 1,2-NPQ-Hb and -Alb were produced in greater quantities than 1,4-NPQ-Hb and -Alb, indicating either that the formation of 1,2-NPQ from NPO is favored or that more than one pathway leads to the formation of 1,2-NPQ. quinone 7-14 albumin Rattus norvegicus 40-43 12367702-1 2002 The diaminopyrimidine derivatives trimethoprim (TMP), pyrimethamine (PMA) and 2,4-diaminopyrimidine (2,4-DAP) are found to react readily and efficiently in an aqueous solution with p-benzoquinone (p-BQ) to form a colored product with an absorption optimum wavelength of about 500 nm. quinone 181-195 death associated protein Homo sapiens 105-108 12367702-1 2002 The diaminopyrimidine derivatives trimethoprim (TMP), pyrimethamine (PMA) and 2,4-diaminopyrimidine (2,4-DAP) are found to react readily and efficiently in an aqueous solution with p-benzoquinone (p-BQ) to form a colored product with an absorption optimum wavelength of about 500 nm. quinone 197-201 death associated protein Homo sapiens 105-108 11881990-1 2002 A series of quinone substrates were modeled into the active site of human DT-diaphorase and minimized. quinone 12-19 NAD(P)H quinone dehydrogenase 1 Homo sapiens 74-87 11862423-0 2002 The effect of functional groups on reduction and activation of quinone bioreductive agents by DT-diaphorase. quinone 63-70 NAD(P)H quinone dehydrogenase 1 Homo sapiens 94-107 11888291-7 2002 Functional motifs identified by site-directed mutagenesis within the C-terminal portion of the tNOX protein corresponding to the processed plasma membrane-associated form include quinone (capsaicin), copper and adenine nucleotide binding domains, and two cysteines essential for catalytic activity. quinone 179-186 ecto-NOX disulfide-thiol exchanger 2 Homo sapiens 95-99 11862423-7 2002 The purpose of this study was to investigate the ability of specific functional groups to modify reduction and activation of quinone bioreductive agents by DT-diaphorase. quinone 125-132 NAD(P)H quinone dehydrogenase 1 Homo sapiens 156-169 11862423-22 2002 All the functional groups decreased the rate of reduction of the quinone group by DT-diaphorase. quinone 65-72 NAD(P)H quinone dehydrogenase 1 Homo sapiens 82-95 11862423-24 2002 Steric effects on reduction by DT-diaphorase were also influenced by the position of the functional group on the quinone ring moiety, as the reduction of m-PBM was much slower than the reduction of PBM. quinone 113-120 NAD(P)H quinone dehydrogenase 1 Homo sapiens 31-44 11853970-5 2002 Cytotoxicity induced by 1,4-benzoquinone was inhibited by antagonists of calmodulin, suggesting that calmodulin could play an important role in platelet toxicity. quinone 24-40 calmodulin 1 Rattus norvegicus 73-83 11853970-5 2002 Cytotoxicity induced by 1,4-benzoquinone was inhibited by antagonists of calmodulin, suggesting that calmodulin could play an important role in platelet toxicity. quinone 24-40 calmodulin 1 Rattus norvegicus 101-111 11853970-6 2002 These results suggested that the progression of events for benzoquinone-induced cytotoxicity in platelets was as follows: 1,4-benzoquinone depletes intracellular ATP; membrane blebbing occurs; calcium homeostasis is disrupted, activation of calmodulin-dependent processes results; finally cytotoxicity occurs. quinone 59-71 calmodulin 1 Rattus norvegicus 241-251 11810042-9 2002 NQO1 results suggest that different quinones (possibly estrogenic quinone metabolites) might affect the histological development of breast tumors. quinone 36-43 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-4 11744399-6 2001 Rapid tautomerism of the ortho-quinone of 4-cyanomethylcatechol to a redox-inactive quinomethane likewise inhibits tyrosinase autoactivation. quinone 31-38 tyrosinase Homo sapiens 115-125 11697955-1 2001 Alkylating agents that react through highly electrophilic quinone methide intermediates often express a specificity for the weakly nucleophilic exocyclic amines of deoxyguanosine (dG N(2)) and deoxyadenosine (dA N(6)) in DNA. quinone 58-65 Odorant receptor 59a Drosophila melanogaster 209-216 11697955-3 2001 Ultimately, the thermodynamically stable dA N(6) isomer accumulates by trapping the quinone methide that is transiently regenerated from collapse of the dA N1 adduct. quinone 84-91 Odorant receptor 59a Drosophila melanogaster 41-48 11603968-1 2001 1-Benzyl-4-tert-butyl-1,4-dihydronicotinamide (t-BuBNAH) reacts efficiently with p-benzoquinone (Q) to yield a [2+3] cycloadduct (1) in the presence of Sc(OTf)(3) (OTf = OSO(2)CF(3)) in deaerated acetonitrile (MeCN) at room temperature, while no reaction occurs in the absence of Sc(3+). quinone 81-95 POU class 5 homeobox 1 Homo sapiens 152-161 11888901-1 2002 Albumin adducts of benzene oxide (BO-Alb) and 1,4-benzoquinone (1,4-BQ-Alb) were investigated among 134 workers exposed to benzene and 51 unexposed controls in Tianjin, China. quinone 46-62 albumin Homo sapiens 0-3 12369976-1 2001 NQO1 (DT-diaphorase) and its truncated isoenzyme, the metalloenzyme NQO2, can reduce quinone substrates by two-electron transfer. quinone 85-92 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-4 11679176-1 2001 NAD(P)H: quinone oxidoreductase (NQO1) protects the cell against cytotoxicity by reducing the concentration of free quinone available for single electron reduction. quinone 9-16 NAD(P)H quinone dehydrogenase 1 Homo sapiens 33-37 11701227-9 2001 The increased risk of leukemia associated with a deficit in NQO1 levels due to the NQO1*2 polymorphism may reflect impaired quinone detoxification and an increased susceptibility of endothelial cells in bone marrow to environmental insults. quinone 124-131 NAD(P)H quinone dehydrogenase 1 Homo sapiens 60-64 11701227-9 2001 The increased risk of leukemia associated with a deficit in NQO1 levels due to the NQO1*2 polymorphism may reflect impaired quinone detoxification and an increased susceptibility of endothelial cells in bone marrow to environmental insults. quinone 124-131 NAD(P)H quinone dehydrogenase 1 Homo sapiens 83-88 12369976-1 2001 NQO1 (DT-diaphorase) and its truncated isoenzyme, the metalloenzyme NQO2, can reduce quinone substrates by two-electron transfer. quinone 85-92 NAD(P)H quinone dehydrogenase 1 Homo sapiens 6-19 12369976-1 2001 NQO1 (DT-diaphorase) and its truncated isoenzyme, the metalloenzyme NQO2, can reduce quinone substrates by two-electron transfer. quinone 85-92 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 68-72 11543641-1 2001 The benzene metabolite hydroquinone (HQ) is postulated to exert its myelotoxicity by bioactivation to reactive quinone derivatives in myeloperoxidase (MPO)-containing cells. quinone 28-35 myeloperoxidase Homo sapiens 134-149 11543641-1 2001 The benzene metabolite hydroquinone (HQ) is postulated to exert its myelotoxicity by bioactivation to reactive quinone derivatives in myeloperoxidase (MPO)-containing cells. quinone 28-35 myeloperoxidase Homo sapiens 151-154 11587640-1 2001 BACKGROUND: NAD(P)H:quinone acceptor oxidoreductase (QR1) protects animal cells from the deleterious and carcinogenic effects of quinones and other electrophiles. quinone 20-27 hydroxysteroid 17-beta dehydrogenase 6 Homo sapiens 37-51 11489749-1 2001 Hemoglobin (Hb) and albumin (Alb) adducts of the benzene metabolites benzene oxide (BO) and 1,4-benzoquinone (1,4-BQ) were analyzed by gas chromatography-mass spectrometry in 43 exposed workers and 44 unexposed controls from Shanghai, China, as part of a larger cross-sectional study of benzene biomarkers. quinone 92-108 albumin Homo sapiens 29-32 11489749-1 2001 Hemoglobin (Hb) and albumin (Alb) adducts of the benzene metabolites benzene oxide (BO) and 1,4-benzoquinone (1,4-BQ) were analyzed by gas chromatography-mass spectrometry in 43 exposed workers and 44 unexposed controls from Shanghai, China, as part of a larger cross-sectional study of benzene biomarkers. quinone 110-116 albumin Homo sapiens 29-32 11489749-4 2001 When compared on an individual basis, Alb adducts of 1,4-BQ and BO and Hb adducts of BO were highly correlated with each other and with urinary phenol and hydroquinone (P < 0.0001 for all of the comparisons). quinone 53-59 albumin Homo sapiens 38-41 11481389-1 2001 BACKGROUND: The phase II enzyme NAD(P)H :quinone oxidoreductase 1 (NQO1) catalyzes quinone detoxification, protecting cells from redox cycling, oxidative stress, mutagenicity, and cytotoxicity induced by quinones and its precursors. quinone 41-48 NAD(P)H dehydrogenase, quinone 1 Mus musculus 67-71 11587640-1 2001 BACKGROUND: NAD(P)H:quinone acceptor oxidoreductase (QR1) protects animal cells from the deleterious and carcinogenic effects of quinones and other electrophiles. quinone 20-27 NAD(P)H quinone dehydrogenase 1 Homo sapiens 53-56 11389877-0 2001 Troglitazone quinone formation catalyzed by human and rat CYP3A: an atypical CYP oxidation reaction. quinone 13-20 cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus 58-63 11466049-5 2001 Addition of redox-active quinone guests AQS, AQC, and BQ to an aqueous solution of [(beta-CD-ttp)Ru(ttp)](2+) results in quenching of the luminescence up to 40%, 20%, and 25%, respectively. quinone 25-32 SH3 domain binding protein 4 Homo sapiens 93-96 11466049-5 2001 Addition of redox-active quinone guests AQS, AQC, and BQ to an aqueous solution of [(beta-CD-ttp)Ru(ttp)](2+) results in quenching of the luminescence up to 40%, 20%, and 25%, respectively. quinone 25-32 SH3 domain binding protein 4 Homo sapiens 100-103 11423658-3 2001 We show that oxidized forms of quinone electron carriers act as direct negative signals that inhibit autophosphorylation of ArcB during aerobiosis. quinone 31-38 hypothetical protein Escherichia coli 124-128 11377380-10 2001 Further studies using streptonigrin, ES921, and RH1 were undertaken to analyze the relationship between NQO1 activity and quinone toxicity. quinone 122-129 NAD(P)H quinone dehydrogenase 1 Homo sapiens 104-108 11511688-1 2001 NAD(P)H:quinone oxidoreductase 1 (NQO1; DT-diaphorase; DTD) is a two-electron reductase that efficiently bioactivates compounds of the quinone family, such as mitomycin C. quinone 8-15 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 11511688-1 2001 NAD(P)H:quinone oxidoreductase 1 (NQO1; DT-diaphorase; DTD) is a two-electron reductase that efficiently bioactivates compounds of the quinone family, such as mitomycin C. quinone 8-15 NAD(P)H quinone dehydrogenase 1 Homo sapiens 40-53 11423146-4 2001 COMT (caffeic acid O-methyl transferase) downregulation in poplar results in the incorporation of 5-hydroxyconiferyl alcohol into lignins via typical radical coupling reactions, but post-coupling quinone methide internal trapping reactions produce novel benzodioxane units in the lignin. quinone 196-203 catechol-O-methyltransferase Homo sapiens 0-4 11423146-4 2001 COMT (caffeic acid O-methyl transferase) downregulation in poplar results in the incorporation of 5-hydroxyconiferyl alcohol into lignins via typical radical coupling reactions, but post-coupling quinone methide internal trapping reactions produce novel benzodioxane units in the lignin. quinone 196-203 catechol-O-methyltransferase Homo sapiens 6-39 11272823-3 2001 A 40644 possessing a sesquiterpene-substituted p-benzoquinone structure with cis-fused B/C ring stereochemistry that inhibits the human thioredoxin system as the well as the growth of several cancer cell lines. quinone 47-61 thioredoxin Homo sapiens 136-147 11405891-5 2001 In contrast to the quinone complex, the thermoinduced transition of the macromolecular RC complex to the state providing effective electron transport from the multiheme cytochrome c to the photoactive bacteriochlorophyll dimer within the temperature range 220-280 K accounts for tens of seconds. quinone 19-26 cytochrome c, somatic Homo sapiens 169-181 11316576-8 2001 We conclude that the tyrosinase-derived reactive quinone intermediate(s) of PA, which binds nucleophilic residues of proteins including sulfhydryl group and conjugates of which are recognized as haptens, was partially involved in alteration of the cellular immune functions including oxygen radical-generating leukocytes migration to inflamed regions. quinone 49-56 tyrosinase Mus musculus 21-31 11254346-0 2001 Electron-Transfer-Induced Molecular Reorientations: The Benzoquinone/Hydroquinone Reaction at Pd(111)-(square3xsquare3)R30 degrees -I Studied by EC-STM. quinone 56-68 sulfotransferase family 1A member 3 Homo sapiens 148-151 11254346-1 2001 The benzoquinone/hydroquinone (Q/H(2)Q) redox reaction has been studied by electrochemical-scanning tunneling microscopy (EC-STM) at a Pd(111)-(square3xsquare3)R30 degrees -I electrode surface in a solution that contained 10(-4) M H(2)Q in 0.05 M H(2)SO(4); iodine-pretreatment of the Pd(111) surface was to prevent chemisorption of organic-derived species. quinone 4-16 sulfotransferase family 1A member 3 Homo sapiens 125-128 11022032-5 2001 It was concluded that both quinone-binding sites responsible for the redox changes of cytochrome b(559) are different from either the Q(A) or Q(B) site in PSII and represent new quinone-binding sites in PSII. quinone 27-34 mitochondrially encoded cytochrome b Homo sapiens 86-98 11022032-5 2001 It was concluded that both quinone-binding sites responsible for the redox changes of cytochrome b(559) are different from either the Q(A) or Q(B) site in PSII and represent new quinone-binding sites in PSII. quinone 178-185 mitochondrially encoded cytochrome b Homo sapiens 86-98 11386757-3 2001 The encoded putative polypeptide of 754 amino acids presented all structural characteristics of the lysyl oxidase (LOX) enzyme family, a copper-binding site with four histidyl residues, the lysyl and tyrosyl residues known to be involved in LOX enzyme in the formation of the quinone cofactor and surrounding sequences, and the cytokine receptor-like domain. quinone 276-283 lysyl oxidase Homo sapiens 100-113 11386757-3 2001 The encoded putative polypeptide of 754 amino acids presented all structural characteristics of the lysyl oxidase (LOX) enzyme family, a copper-binding site with four histidyl residues, the lysyl and tyrosyl residues known to be involved in LOX enzyme in the formation of the quinone cofactor and surrounding sequences, and the cytokine receptor-like domain. quinone 276-283 lysyl oxidase Homo sapiens 115-118 11286987-1 2001 NAD(P)H:(quinone acceptor)oxidoreductase (DT-diaphorase) is a two-electron reducing enzyme that activates bioreductive antitumor agents and is induced by a wide variety of compounds including 1,2-dithiole-3-thione (D3T). quinone 9-16 NAD(P)H quinone dehydrogenase 1 Homo sapiens 42-55 11244089-0 2001 Altered quinone biosynthesis in the long-lived clk-1 mutants of Caenorhabditis elegans. quinone 8-15 5-demethoxyubiquinone hydroxylase, mitochondrial Caenorhabditis elegans 47-52 11226418-0 2001 Dopamine beta-hydroxylase inactivation generates a protein-bound quinone derivative. quinone 65-72 dopamine beta-hydroxylase Bos taurus 0-25 11170441-2 2001 We investigated whether etoposide catechol and quinone metabolites can damage the MLL breakpoint cluster region in a DNA topoisomerase II-dependent manner like the parent drug and the nature of the damage. quinone 47-54 lysine methyltransferase 2A Homo sapiens 82-85 11249127-5 2001 Quinone methide 7 showed the most potent activity with 0.5-1 microg/mL of MIC against both MRSA and VRE. quinone 0-7 solute carrier family 9 member A6 Homo sapiens 91-95 11156574-3 2001 The copper-containing enzyme, tyrosinase, which catalyses the hydroxylation of monophenols to diphenols and the subsequent oxidation of these to the respective unstable quinone, failed to generate nitric oxide from Angeli"s salt by itself, but did so in the presence of tyrosine. quinone 169-176 tyrosinase Rattus norvegicus 30-40 11678450-0 2001 AVEMAR (a new benzoquinone-containing natural product) administration interferes with the Th2 response in experimental SLE and promotes amelioration of the disease. quinone 14-26 heart and neural crest derivatives expressed 2 Mus musculus 90-93 11865975-4 2001 Compared to Neo control cells, BCL-2-expressing cells are more resistant to the killing and growth retardation induced by hydrogen peroxide, superoxide, or by the oxygen radical-generating quinone-containing compounds menadione, diaziquone and adriamycin. quinone 189-196 BCL2 apoptosis regulator Homo sapiens 31-36 11865975-7 2001 Hydroxyl radical levels generated by the quinone-containing agents were low in BCL-2-expressing JB6 cells compared to control Neo cells. quinone 41-48 BCL2 apoptosis regulator Homo sapiens 79-84 11134896-9 2001 We suggest that NAC can perpetuate the redox cycle between the quinone and the semiquinone forms of the catecholestrogens, thereby enhancing the production of ROS. quinone 63-70 synuclein alpha Homo sapiens 16-19 10956224-0 2000 Development of novel quinone phosphorodiamidate prodrugs targeted to DT-diaphorase. quinone 21-28 NAD(P)H quinone dehydrogenase 1 Homo sapiens 69-82 11035252-2 2000 One defense against quinone toxicity is the enzyme NAD(P)H:quinone oxidoreductase type 1 (QR1), which metabolizes quinones by a two-electron reduction mechanism, thus averting production of radicals. quinone 20-27 NAD(P)H quinone dehydrogenase 1 Homo sapiens 59-93 10956058-13 2000 Implied involvement of a reactive quinone in the liver and brain of TCB-treated rats supports the idea that quinonoid metabolites may be important contributors to PCB-derived oxidative damage to genomic DNA. quinone 34-41 pyruvate carboxylase Rattus norvegicus 163-166 11035255-0 2000 The role of NAD(P)H oxidoreductase (DT-Diaphorase) in the bioactivation of quinone-containing antitumor agents: a review. quinone 75-82 NAD(P)H quinone dehydrogenase 1 Homo sapiens 36-49 11035255-2 2000 In this review we focus on the two electron enzymatic reduction/activation of quinone-containing anticancer agents by DT Diaphorase (DTD). quinone 78-85 NAD(P)H quinone dehydrogenase 1 Homo sapiens 118-131 10924903-2 2000 The recombinant neuronal nitric oxide synthase (nNOS) reductase domain, which contains the FAD-FMN prosthetic group pair and calmodulin-binding site, catalyzed aerobic NADPH-oxidation in the presence of the model quinone compound menadione (MD), including antitumor mitomycin C (Mit C) and adriamycin (Adr). quinone 213-220 nitric oxide synthase 1 Homo sapiens 16-46 10924903-2 2000 The recombinant neuronal nitric oxide synthase (nNOS) reductase domain, which contains the FAD-FMN prosthetic group pair and calmodulin-binding site, catalyzed aerobic NADPH-oxidation in the presence of the model quinone compound menadione (MD), including antitumor mitomycin C (Mit C) and adriamycin (Adr). quinone 213-220 nitric oxide synthase 1 Homo sapiens 48-52 10924903-2 2000 The recombinant neuronal nitric oxide synthase (nNOS) reductase domain, which contains the FAD-FMN prosthetic group pair and calmodulin-binding site, catalyzed aerobic NADPH-oxidation in the presence of the model quinone compound menadione (MD), including antitumor mitomycin C (Mit C) and adriamycin (Adr). quinone 213-220 formin 1 Homo sapiens 95-98 10825465-0 2000 Role of NAD(P)H:quinone oxidoreductase 1 (DT diaphorase) in protection against quinone toxicity. quinone 16-23 NAD(P)H dehydrogenase, quinone 1 Mus musculus 42-55 10825465-11 2000 The various results from CHO cells and NQO1-/- mice indicated that NQO1 protects against quinone-induced cytotoxicity, as well as DNA and membrane damage. quinone 89-96 NAD(P)H dehydrogenase, quinone 1 Mus musculus 67-71 10910079-2 2000 NAD(P)H:(quinone acceptor) oxidoreductase (NQO1) is an antioxidant enzyme with particular relevance to cancer. quinone 9-16 thioredoxin reductase 1 Homo sapiens 27-41 10910079-2 2000 NAD(P)H:(quinone acceptor) oxidoreductase (NQO1) is an antioxidant enzyme with particular relevance to cancer. quinone 9-16 NAD(P)H quinone dehydrogenase 1 Homo sapiens 43-47 11035256-1 2000 DT-diaphorase, also referred to as NQO1 or NAD(P)H: quinone acceptor oxidoreductase, is a flavoprotein that catalyzes the two-electron reduction of quinones and quinonoid compounds to hydroquinones, using either NADH or NADPH as the electron donor. quinone 52-59 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-13 10877993-10 2000 In this review, the current state of research on quinone-containing alkylating agents is discussed with the focus on NQO1-directed bioreductive drug development. quinone 49-56 NAD(P)H quinone dehydrogenase 1 Homo sapiens 117-121 10820062-1 2000 This paper deals with the interactions of chlorogenic, caffeic, and quinic acids and p-quinone with myoglobin. quinone 85-94 myoglobin Homo sapiens 100-109 10871340-4 2000 Nevertheless, these mutant proteins still bind efficiently to oligonucleotides containing either AP sites or the chemically unrelated bulky p-benzoquinone (pBQ) derivatives of dC, dA and dG, all of which are substrates for HAP1. quinone 140-154 huntingtin associated protein 1 Homo sapiens 223-227 10871340-4 2000 Nevertheless, these mutant proteins still bind efficiently to oligonucleotides containing either AP sites or the chemically unrelated bulky p-benzoquinone (pBQ) derivatives of dC, dA and dG, all of which are substrates for HAP1. quinone 156-159 huntingtin associated protein 1 Homo sapiens 223-227 10871340-6 2000 Through analysis of the binding of Asp-210 substitution mutants to oligonucleotides containing either an AP site or a pBQ adduct, we conclude that the absence of Asp-210 allows the formation of a stable HAP1-substrate complex that exists only transiently during the catalytic cycle of wild-type HAP1 protein. quinone 118-121 huntingtin associated protein 1 Homo sapiens 203-207 10826653-1 2000 Our previous results indicated that cytochrome P450 destruction by benzene metabolites was caused mainly by benzoquinone (Soucek et al., Biochem. quinone 108-120 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 36-51 10706635-1 2000 NAD(P)H/quinone acceptor oxidoreductase (QR1, NQO1, formerly DT-diaphorase; EC ) protects animal cells from the deleterious and carcinogenic effects of quinones and other electrophiles. quinone 8-15 NAD(P)H quinone dehydrogenase 1 Homo sapiens 41-44 10730823-5 2000 The rates of autoxidation of all compounds except the halogen derivatives and 5-hydroxy-1,4-naphthohydroquinone were increased by addition of the parent naphthoquinone, and quinone addition partially or completely overcame the inhibitory effect of SOD. quinone 104-111 superoxide dismutase 1 Homo sapiens 248-251 10813903-0 2000 NBS-Promoted reactions of symmetrically hindered methylphenols via p-benzoquinone methide Symmetrically hindered methylphenols 1 react smoothly with NBS to form transient intermediates, p-benzoquinone methides (BM), which can be further processed to give hydroxybenzaldehydes in the presence of DMSO. quinone 67-81 nibrin Homo sapiens 0-3 10813903-0 2000 NBS-Promoted reactions of symmetrically hindered methylphenols via p-benzoquinone methide Symmetrically hindered methylphenols 1 react smoothly with NBS to form transient intermediates, p-benzoquinone methides (BM), which can be further processed to give hydroxybenzaldehydes in the presence of DMSO. quinone 67-81 nibrin Homo sapiens 149-152 10781884-3 2000 The possibility that ERAB mediates quinone reduction is therefore investigated, thus giving the potential of redoxcycling and production of reactive oxygen species, leading to lipid peroxidation. quinone 35-42 hydroxysteroid 17-beta dehydrogenase 10 Homo sapiens 21-25 10816041-9 2000 This "oxidant-induced reduction" of cytochrome b suggests that electron transport from sulfide to oxygen in A. aeolicus employs the cytochrome bc complex via the quinone pool. quinone 162-169 petB Aquifex aeolicus VF5 36-48 10722691-3 2000 Room temperature continuous wave EPR measurements at X-band of whole cells of menA and menB interruption mutants show a transient reduction and oxidation of an organic radical with a g-value and anisotropy characteristic of a quinone. quinone 226-233 ENAH actin regulator Homo sapiens 78-82 10785555-2 2000 Compared with 2-acyl-DMNQ derivatives, 6-acyl-DMNQ compounds, bearing a higher electrophilic quinone moiety, showed a higher potency in the inhibition of DNA topoisomerase I and the cytotoxicity, implying the possible participation of electrophilic arylation in their bioactivities. quinone 93-100 topoisomerase (DNA) I Mus musculus 154-173 10746935-6 2000 Although adducts from reactions of BO and 1,4-BQ with Alb both decayed with rates consistent with those of Alb turnover in the rat, the half-life for 1,4-BQ-Alb (2.5 days) was shorter than that for BO-Alb (3.1 days), suggesting some instability of 1,4-BQ-Alb. quinone 42-48 albumin Rattus norvegicus 54-57 10746935-6 2000 Although adducts from reactions of BO and 1,4-BQ with Alb both decayed with rates consistent with those of Alb turnover in the rat, the half-life for 1,4-BQ-Alb (2.5 days) was shorter than that for BO-Alb (3.1 days), suggesting some instability of 1,4-BQ-Alb. quinone 42-48 albumin Rattus norvegicus 107-110 10746935-6 2000 Although adducts from reactions of BO and 1,4-BQ with Alb both decayed with rates consistent with those of Alb turnover in the rat, the half-life for 1,4-BQ-Alb (2.5 days) was shorter than that for BO-Alb (3.1 days), suggesting some instability of 1,4-BQ-Alb. quinone 42-48 albumin Rattus norvegicus 107-110 10746935-6 2000 Although adducts from reactions of BO and 1,4-BQ with Alb both decayed with rates consistent with those of Alb turnover in the rat, the half-life for 1,4-BQ-Alb (2.5 days) was shorter than that for BO-Alb (3.1 days), suggesting some instability of 1,4-BQ-Alb. quinone 42-48 albumin Rattus norvegicus 107-110 10746935-6 2000 Although adducts from reactions of BO and 1,4-BQ with Alb both decayed with rates consistent with those of Alb turnover in the rat, the half-life for 1,4-BQ-Alb (2.5 days) was shorter than that for BO-Alb (3.1 days), suggesting some instability of 1,4-BQ-Alb. quinone 42-48 albumin Rattus norvegicus 107-110 10681517-6 2000 Biochemical studies suggest that reduction of beta-lapachone by NQO1 leads to a futile cycling between the quinone and hydroquinone forms, with a concomitant loss of reduced NAD(P)H. In addition, the activation of a cysteine protease, which has characteristics consistent with the neutral calcium-dependent protease, calpain, is observed after beta-lapachone treatment. quinone 107-114 NAD(P)H quinone dehydrogenase 1 Homo sapiens 64-68 10691689-3 2000 Since only the quinone form of the APBIs can intercalate DNA, two-electron reduction to the hydroquinone by DT-diaphorase is known to deactivate these compounds. quinone 15-22 NAD(P)H quinone dehydrogenase 1 Homo sapiens 108-121 10691689-5 2000 Therefore one feature of the ABPI structural variants is the excessive bulk about the quinone ring, which was predicted to diminish DT-diaphorase substrate activity. quinone 86-93 NAD(P)H quinone dehydrogenase 1 Homo sapiens 132-145 10706635-1 2000 NAD(P)H/quinone acceptor oxidoreductase (QR1, NQO1, formerly DT-diaphorase; EC ) protects animal cells from the deleterious and carcinogenic effects of quinones and other electrophiles. quinone 8-15 NAD(P)H quinone dehydrogenase 1 Homo sapiens 46-50 10706635-1 2000 NAD(P)H/quinone acceptor oxidoreductase (QR1, NQO1, formerly DT-diaphorase; EC ) protects animal cells from the deleterious and carcinogenic effects of quinones and other electrophiles. quinone 8-15 NAD(P)H quinone dehydrogenase 1 Homo sapiens 61-74 10535745-9 1999 These results suggest that ethanol inhibited not only the microsomal (CYP2E1 mediated) formation of a toxic quinone metabolite from APAP, but also accelerated the conversion of the toxic quinone metabolite produced back to APAP by stimulating cytoplasmic QR activity. quinone 108-115 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 70-76 10659951-8 2000 For the three metabolites of troglitazone tested, a quinone-type metabolite (M3) was the most potent inhibitor for CYP2C enzymes, followed by a sulphate conjugate (M1); effects of a glucuronide (M2) were very weak. quinone 52-59 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 115-120 10534310-0 1999 Oxidation of troglitazone to a quinone-type metabolite catalyzed by cytochrome P-450 2C8 and P-450 3A4 in human liver microsomes. quinone 31-38 cytochrome P450 family 2 subfamily C member 8 Homo sapiens 68-88 10761994-0 2000 Tyrosinase-mediated formation of a reactive quinone from the depigmenting agents, 4-tert-butylphenol and 4-tert-butylcatechol. quinone 44-51 tyrosinase Homo sapiens 0-10 10534310-2 1999 Of fourteen cDNA-expressed human P-450 enzymes examined, CYP1A1, CYP2C8, CYP2C19, and CYP3A4 were active in catalyzing formation of a quinone-type metabolite at a concentration of 10 microM troglitazone, whereas CYP3A4 had the highest catalytic activity at 100 microM substrate. quinone 134-141 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 57-63 10534310-2 1999 Of fourteen cDNA-expressed human P-450 enzymes examined, CYP1A1, CYP2C8, CYP2C19, and CYP3A4 were active in catalyzing formation of a quinone-type metabolite at a concentration of 10 microM troglitazone, whereas CYP3A4 had the highest catalytic activity at 100 microM substrate. quinone 134-141 cytochrome P450 family 2 subfamily C member 8 Homo sapiens 65-71 10534310-5 1999 Anti-CYP2C antibodies strongly inhibited quinone-type metabolite formation (at 10 microM troglitazone) in CYP2C-rich human liver microsomes (by approximately 85%); the intensity of this effect depended on the human samples and their P-450 status. quinone 41-48 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 106-111 10534310-2 1999 Of fourteen cDNA-expressed human P-450 enzymes examined, CYP1A1, CYP2C8, CYP2C19, and CYP3A4 were active in catalyzing formation of a quinone-type metabolite at a concentration of 10 microM troglitazone, whereas CYP3A4 had the highest catalytic activity at 100 microM substrate. quinone 134-141 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 73-80 10534310-6 1999 The results suggest that in human liver both CYP2C8 and CYP3A4 have major roles in quinone-type metabolite formation and that the hepatic contents of these two P-450 forms determine which P-450 enzymes play major roles in individual humans. quinone 83-90 cytochrome P450 family 2 subfamily C member 8 Homo sapiens 45-51 10534310-2 1999 Of fourteen cDNA-expressed human P-450 enzymes examined, CYP1A1, CYP2C8, CYP2C19, and CYP3A4 were active in catalyzing formation of a quinone-type metabolite at a concentration of 10 microM troglitazone, whereas CYP3A4 had the highest catalytic activity at 100 microM substrate. quinone 134-141 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 86-92 10534310-6 1999 The results suggest that in human liver both CYP2C8 and CYP3A4 have major roles in quinone-type metabolite formation and that the hepatic contents of these two P-450 forms determine which P-450 enzymes play major roles in individual humans. quinone 83-90 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 56-62 10534310-7 1999 CYP3A4 may be expected to play a role in formation of quinone-type metabolite from troglitazone even at a low concentration in humans. quinone 54-61 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 0-6 10534310-2 1999 Of fourteen cDNA-expressed human P-450 enzymes examined, CYP1A1, CYP2C8, CYP2C19, and CYP3A4 were active in catalyzing formation of a quinone-type metabolite at a concentration of 10 microM troglitazone, whereas CYP3A4 had the highest catalytic activity at 100 microM substrate. quinone 134-141 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 212-218 10534310-4 1999 Quercetin efficiently inhibited quinone-type metabolite formation (at 10 microM troglitazone) in human samples that contained relatively high levels of CYP2C, whereas ketoconazole affected these activities in liver microsomes in which CYP3A4 levels were relatively high. quinone 32-39 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 152-157 10534310-5 1999 Anti-CYP2C antibodies strongly inhibited quinone-type metabolite formation (at 10 microM troglitazone) in CYP2C-rich human liver microsomes (by approximately 85%); the intensity of this effect depended on the human samples and their P-450 status. quinone 41-48 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 5-10 10461926-4 1999 Quinone modification of tyrosine hydroxylase modifies enzyme sulfhydryl groups and results in the formation of cysteinyl-catechols within the enzyme. quinone 0-7 tyrosine hydroxylase Homo sapiens 24-44 10748880-1 1999 AIMS: The two electron reduction of quinones to hydroquinones by NAD(P)H quinone oxidoreductase (NQO1) plays an important role in both activation and detoxification of quinone and similarly reactive compounds. quinone 36-43 NAD(P)H quinone dehydrogenase 1 Homo sapiens 97-101 10644007-3 1999 Here we show that MIF is able to catalyze the conversion of dopaminechrome and norepinephrinechrome, toxic quinone products of the neurotransmitters dopamine and norepinephrine, respectively, to indole derivatives that may serve as precursors to neuromelanin. quinone 107-114 macrophage migration inhibitory factor Homo sapiens 18-21 10850313-0 1999 MSC, a new benzoquinone-containing natural product with antimetastatic effect. quinone 11-23 musculin Mus musculus 0-3 10438531-10 1999 MAO A partially purified from yeast grown on 8-nor-8-chlororiboflavin exhibited an absorption spectrum indicating the covalent flavin is an 8-nor-8-S-thioflavin, suggesting a nucleophilic displacement mechanism that supports the quinone-methide mechanism previously suggested as a general mechanism for covalent flavin attachment. quinone 229-236 monoamine oxidase A Homo sapiens 0-5 10850313-1 1999 An orally applicable fermentation product of wheat germ containing 0.04% substituted benzoquinone (MSC) has been invented by Hungarian chemists under the trade name of AVEMAR. quinone 85-97 musculin Mus musculus 99-102 10368308-3 1999 NAD(P)H:quinone oxidoreductase (NQO1) is an enzyme capable of reducing the oxidized quinone metabolites and thereby potentially reducing their toxicities. quinone 8-15 NAD(P)H quinone dehydrogenase 1 Homo sapiens 32-36 10462055-4 1999 This study followed the ability of quinonic benzene metabolites (catechol, hydroquinone, and benzoquinone) to destroy CYP in liver microsomes from rats pretreated with various inducers and in human liver microsomes. quinone 93-105 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 118-121 10085111-0 1999 Identification of quinone-binding and heme-ligating residues of the smallest membrane-anchoring subunit (QPs3) of bovine heart mitochondrial succinate:ubiquinone reductase. quinone 18-25 succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial Bos taurus 105-109 11671039-5 1999 Application of transient absorption, time-resolved resonance Raman, and time-resolved infrared spectroscopies proves that this transient is the redox-separated state fac-[Re(I)(Aqphen(*)(-)())(CO)(3)(py-PTZ(*)(+)())](+) in which the excited electron is localized largely on the quinone portion of the Aqphen ligand. quinone 278-285 FA complementation group C Homo sapiens 166-169 10092053-3 1999 Two-electron reduction of the quinone intermediates by DT-diaphorase is considered to be a detoxication pathway since the resulting hydroquinone may be readily conjugated and excreted. quinone 30-37 NAD(P)H dehydrogenase, quinone 1 Mus musculus 55-68 10220560-3 1999 Doxorubicin, 1,4-naphthoquinone (NQ), and 1, 4-benzoquinone (BQ) are found to selectively and dose-dependently interact with a class of hyperreactive sulfhydryl groups localized on ryanodine-sensitive Ca2+ channels [ryanodine receptor (RyR)], and its associated protein, triadin, of skeletal type channels. quinone 42-59 ryanodine receptor 1 Homo sapiens 236-239 10220560-8 1999 These results provide evidence that nanomolar quinone selectively and reversibly alters the redox state of hyperreactive sulfhydryls localized in the RyR/Ca2+ channel complex, resulting in enhanced channel activation. quinone 46-53 ryanodine receptor 1 Homo sapiens 150-153 9920865-3 1999 Here we show that MIF is able to catalyze the conversion of 3,4-dihydroxyphenylaminechrome and norepinephrinechrome, toxic quinone products of the neurotransmitter catecholamines 3,4-dihydroxyphenylamine and norepinephrine, to indoledihydroxy derivatives that may serve as precursors to neuromelanin. quinone 123-130 macrophage migration inhibitory factor Homo sapiens 18-21 10220568-3 1999 This study demonstrates that ectopic expression of Bcl-2 effectively suppresses benzene-active metabolites, 1,4-hydroquinone- and 1, 4-benzoquinone-induced apoptosis in human leukemic HL-60 cells, as evidenced by morphological changes and DNA fragmentation. quinone 130-147 BCL2 apoptosis regulator Homo sapiens 51-56 10037708-0 1999 Inactivation of both RNA binding and aconitase activities of iron regulatory protein-1 by quinone-induced oxidative stress. quinone 90-97 aconitase 1 Homo sapiens 61-86 10037708-4 1999 Here, we study the effects of intracellular quinone-induced oxidative stress on IRP-1. quinone 44-51 aconitase 1 Homo sapiens 80-85 9920282-0 1999 Quinone toxicity in DT-diaphorase-efficient and -deficient colon carcinoma cell lines. quinone 0-7 NAD(P)H quinone dehydrogenase 1 Homo sapiens 20-33 10416018-3 1999 Recently, high-resolution structures of the mitochondrial bc1 complex showed quinone binding sites at one of the transmembrane helices of cytochrome b, and two potentially protonatable histidine residues on the Rieske iron-sulfur protein. quinone 77-84 mitochondrially encoded cytochrome b Homo sapiens 138-150 9822546-0 1998 Indolequinone antitumor agents: correlation between quinone structure, rate of metabolism by recombinant human NAD(P)H:quinone oxidoreductase, and in vitro cytotoxicity. quinone 6-13 crystallin zeta Homo sapiens 119-141 10190545-5 1999 However, when the DNA-modified electrode was immersed in a MC solution and potentials corresponding to the quinone moiety reduction (- 0.3 V or more negative vs. SCE) were applied, an intrastrand bifunctional adduct between C-1 and C-10 of MC and two N-7 of a pair of adjacent guanines in ssDNA were formed at the electrode, reduced at - 0.49 V, i.e. 50 mV more negative than the monoadduct. quinone 107-114 heterogeneous nuclear ribonucleoprotein C Homo sapiens 224-227 10190545-5 1999 However, when the DNA-modified electrode was immersed in a MC solution and potentials corresponding to the quinone moiety reduction (- 0.3 V or more negative vs. SCE) were applied, an intrastrand bifunctional adduct between C-1 and C-10 of MC and two N-7 of a pair of adjacent guanines in ssDNA were formed at the electrode, reduced at - 0.49 V, i.e. 50 mV more negative than the monoadduct. quinone 107-114 homeobox C10 Homo sapiens 232-236 11127812-2 1999 Our results show that the quinone fraction (QF) is a reversible and concentration-dependent inhibitor of human platelet aggregation induced by ADP, arachidonic acid (AA), collagen and thrombin. quinone 26-33 coagulation factor II, thrombin Homo sapiens 184-192 9789061-3 1998 CYP3A metabolism generates epipodophyllotoxin catechol and quinone metabolites, which could damage DNA. quinone 59-66 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 0-5 9670973-4 1998 We demonstrate that a representative PAH, beta-napthoflavone (BNF), and a representative quinone metabolite, tert-butylhydroxyquinone (tBHQ), induce Jun kinase and p38 mitogen-activated protein kinase activities in parallel with the generation of activator protein-1 (AP-1) mobility shift complexes in THP-1 and RAW264.7 macrophage cell lines. quinone 89-96 GLI family zinc finger 2 Homo sapiens 302-307 9790513-2 1998 Along with redox cycling induced by a reductase, a similar process is known to occur via electron transfer from ascorbate (AscH-) to Q with formation of a semiquinone radical (Q.-): (1) Q + AscH- (k1)--> Q.- + Asc.- + H+ (2) Q.- + O2 --> Q + O2.-. quinone 133-134 PYD and CARD domain containing Homo sapiens 123-126 9731717-1 1998 NAD(P)H:quinone oxidoreductase (NQO1) catalyses the two-electron reduction of quinone compounds. quinone 8-15 NAD(P)H quinone dehydrogenase 1 Homo sapiens 32-36 9690517-3 1998 We have shown earlier that the quinone 3,6-diaziridinyl-1,4-benzoquinone (DZQ) leads to the increased expression of p21waf1/cip1/sdi1 protein, an inhibitor of cyclin-dependent kinases. quinone 31-38 cyclin dependent kinase inhibitor 1A Homo sapiens 116-128 9690517-3 1998 We have shown earlier that the quinone 3,6-diaziridinyl-1,4-benzoquinone (DZQ) leads to the increased expression of p21waf1/cip1/sdi1 protein, an inhibitor of cyclin-dependent kinases. quinone 31-38 cyclin dependent kinase inhibitor 1A Homo sapiens 129-133 9670973-4 1998 We demonstrate that a representative PAH, beta-napthoflavone (BNF), and a representative quinone metabolite, tert-butylhydroxyquinone (tBHQ), induce Jun kinase and p38 mitogen-activated protein kinase activities in parallel with the generation of activator protein-1 (AP-1) mobility shift complexes in THP-1 and RAW264.7 macrophage cell lines. quinone 89-96 mitogen-activated protein kinase 9 Homo sapiens 149-159 9670973-4 1998 We demonstrate that a representative PAH, beta-napthoflavone (BNF), and a representative quinone metabolite, tert-butylhydroxyquinone (tBHQ), induce Jun kinase and p38 mitogen-activated protein kinase activities in parallel with the generation of activator protein-1 (AP-1) mobility shift complexes in THP-1 and RAW264.7 macrophage cell lines. quinone 89-96 mitogen-activated protein kinase 14 Homo sapiens 164-167 9670973-4 1998 We demonstrate that a representative PAH, beta-napthoflavone (BNF), and a representative quinone metabolite, tert-butylhydroxyquinone (tBHQ), induce Jun kinase and p38 mitogen-activated protein kinase activities in parallel with the generation of activator protein-1 (AP-1) mobility shift complexes in THP-1 and RAW264.7 macrophage cell lines. quinone 89-96 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 247-266 9670973-4 1998 We demonstrate that a representative PAH, beta-napthoflavone (BNF), and a representative quinone metabolite, tert-butylhydroxyquinone (tBHQ), induce Jun kinase and p38 mitogen-activated protein kinase activities in parallel with the generation of activator protein-1 (AP-1) mobility shift complexes in THP-1 and RAW264.7 macrophage cell lines. quinone 89-96 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 268-272 9826945-1 1998 A new method has been developed to detect mono-S-substituted cysteinyl adducts of 1,2- and 1,4-benzoquinone (BQ) in hemoglobin (Hb) and albumin (Alb). quinone 109-111 albumin Rattus norvegicus 145-148 9748120-3 1998 NQO1 can bioactivate antitumor quinones such as mitomycin C, and new quinone-based drugs are currently being developed to target this enzyme in tumors such as NSCLC. quinone 31-38 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-4 9744574-6 1998 Catalase also inhibited DNA damage induced by BHT-quinone, but not that induced by BHT-OOH. quinone 50-57 catalase Homo sapiens 0-8 9683193-3 1998 Here we used immunocytochemisty to test the postulate that catechol-O-methyltransferase (COMT), the enzyme that can prevent oxidation of catecholestrogens to their quinone derivatives, would be induced in renal cortex of hamsters treated with estradiol or ethinyl estradiol. quinone 164-171 catechol-O-methyltransferase Homo sapiens 89-93 9730319-1 1998 Evidence is presented for the binding of the quinone oxidation product of the monohydric phenol substrate, 4-hydroxyanisole, to mushroom tyrosinase. quinone 45-52 tyrosinase Homo sapiens 137-147 9588882-1 1998 Exposing neonatal rat heart myocytes to the redox cycling quinone naphthazarin (5,8-dihydroxy-1,4-naphthoquinone) for 15 to 45 minutes led to a time-dependent release of cathepsin D from many secondary lysosomes to the cytosol, as analyzed by morphometry. quinone 58-65 cathepsin D Rattus norvegicus 170-181 9572303-4 1998 Based on its quinone structure, we hypothesized that LY 83583 was a substrate for the enzyme NAD(P)H:quinone oxidoreductase. quinone 13-20 crystallin zeta Homo sapiens 101-123 9586815-1 1998 Reactive oxygen species generated during the metabolism of the antitumor quinone 3,6-diaziridinyl-1,4-benzoquinone (DZQ) in human colonic carcinoma HCT116 cells lead to the induction of p21 (WAF1, Cip1, or sdi1), an upstream regulator of the retinoblastoma gene product pRb involved G1 cell cycle control. quinone 73-80 cyclin dependent kinase inhibitor 1A Homo sapiens 186-189 9548807-10 1998 Thiotepa, a non-quinone aziridine-containing agent, and 1,4-benzoquinone (p-BQ), a redox cycling quinone, increased p53 levels. quinone 56-72 tumor protein p53 Homo sapiens 116-119 9548807-10 1998 Thiotepa, a non-quinone aziridine-containing agent, and 1,4-benzoquinone (p-BQ), a redox cycling quinone, increased p53 levels. quinone 65-72 tumor protein p53 Homo sapiens 116-119 9548807-13 1998 Moreover, the induction of p53 by AZQ requires both the quinone and the aziridine moieties of the AZQ molecule. quinone 56-63 tumor protein p53 Homo sapiens 27-30 9521088-9 1998 The recent introduction of the benzoquinone antibiotic geldanamycin has facilitated the identification of proteins that are chaperoned by the hsp90-based system. quinone 31-43 Hsp90 family chaperone HSP82 Saccharomyces cerevisiae S288C 142-147 9625728-2 1998 The inhibition of citrulline formation from l-arginine by quinones, which exhibit one-electron reduction potentials (E17) ranging between -240 and -100 mV, increased at a more positive one-electron reduction potential, suggesting that quinone appears to act as an electron acceptor for nNOS. quinone 58-65 nitric oxide synthase 1 Rattus norvegicus 286-290 9538013-0 1998 Identification of the quinone cofactor in mammalian semicarbazide-sensitive amine oxidase. quinone 22-29 amine oxidase copper containing 2 Homo sapiens 52-89 9579828-1 1998 DT-diaphorase, a homodimeric flavoenzyme, can provide for a defence mechanism against carcinogenesis mediated by dietary or environmental quinones as well as bioactivate quinone-containing chemotherapeutic drugs. quinone 138-145 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-13 9548807-0 1998 Induction of p53 by the concerted actions of aziridine and quinone moieties of diaziquone. quinone 59-66 tumor protein p53 Homo sapiens 13-16 9516435-5 1998 These results establish a role for NQO1 in protection against quinone toxicity. quinone 62-69 NAD(P)H dehydrogenase, quinone 1 Mus musculus 35-39 9546049-10 1998 In several cases, the kcat of quinone reduction exceeded kcat of TRX reduction, suggesting that quinones intercepted electron flux from TR to TRX. quinone 30-37 thioredoxin H-type 1 Arabidopsis thaliana 142-145 9546049-11 1998 Incubation of reduced TR with alkylating quinones resulted in a rapid loss of TRX-reductase activity, while quinone reduction rate was unchanged. quinone 41-48 thioredoxin H-type 1 Arabidopsis thaliana 78-81 9546049-15 1998 The relatively high rate of quinone reduction by A. thaliana thioredoxin reductase accompanied by their redox cycling, confers pro-oxidant properties to this antioxidant enzyme. quinone 28-35 thioredoxin H-type 1 Arabidopsis thaliana 61-72 9586815-1 1998 Reactive oxygen species generated during the metabolism of the antitumor quinone 3,6-diaziridinyl-1,4-benzoquinone (DZQ) in human colonic carcinoma HCT116 cells lead to the induction of p21 (WAF1, Cip1, or sdi1), an upstream regulator of the retinoblastoma gene product pRb involved G1 cell cycle control. quinone 73-80 cyclin dependent kinase inhibitor 1A Homo sapiens 191-195 9586815-1 1998 Reactive oxygen species generated during the metabolism of the antitumor quinone 3,6-diaziridinyl-1,4-benzoquinone (DZQ) in human colonic carcinoma HCT116 cells lead to the induction of p21 (WAF1, Cip1, or sdi1), an upstream regulator of the retinoblastoma gene product pRb involved G1 cell cycle control. quinone 73-80 cyclin dependent kinase inhibitor 1A Homo sapiens 197-201 9586815-1 1998 Reactive oxygen species generated during the metabolism of the antitumor quinone 3,6-diaziridinyl-1,4-benzoquinone (DZQ) in human colonic carcinoma HCT116 cells lead to the induction of p21 (WAF1, Cip1, or sdi1), an upstream regulator of the retinoblastoma gene product pRb involved G1 cell cycle control. quinone 73-80 cyclin dependent kinase inhibitor 1A Homo sapiens 206-210 9586815-1 1998 Reactive oxygen species generated during the metabolism of the antitumor quinone 3,6-diaziridinyl-1,4-benzoquinone (DZQ) in human colonic carcinoma HCT116 cells lead to the induction of p21 (WAF1, Cip1, or sdi1), an upstream regulator of the retinoblastoma gene product pRb involved G1 cell cycle control. quinone 73-80 RB transcriptional corepressor 1 Homo sapiens 270-273 21160545-4 1997 We observed that the principal benzene metabolites, represented by hydroquinone, 1,4-benzoquinone, phenol, 1,2,4-benzenetriol, and catechol, significantly alters the production of transforming growth factor of (TGF)-alpha and interleukin (IL)-8 in human epidermal keratinocyte cultures. quinone 81-97 transforming growth factor alpha Homo sapiens 211-221 9495807-0 1998 The ortho-quinone metabolite of the anticancer drug etoposide (VP-16) is a potent inhibitor of the topoisomerase II/DNA cleavable complex. quinone 10-17 host cell factor C1 Homo sapiens 63-68 9526115-2 1998 The process is due to the electron transfer from AscH- to quinone (Q): Q + AscH- --> Q*- + Asc.- + H+ (1), followed by semiquinone (Q.-) oxidation: Q.- + O2 --> Q + O2.- (2). quinone 58-65 PYD and CARD domain containing Homo sapiens 49-52 9551916-0 1998 Nuclear targeted suppression of NF-kappa B activity by the novel quinone derivative E3330. quinone 65-72 nuclear factor kappa B subunit 1 Homo sapiens 32-42 9551916-2 1998 In the present study, we found that a novel quinone derivative E3330 selectively inhibited NF-kappa B-mediated gene expression without affecting any of these steps. quinone 44-51 nuclear factor kappa B subunit 1 Homo sapiens 91-101 9597155-5 1998 In addition, the frequent localization of gamma-glutamyl transpeptidase to cells separating the circulation from a second fluid-filled compartment coincides with tissues that are susceptible either to polyphenolic-GSH conjugate-induced toxicity or to quinone and reactive oxygen species-induced toxicity. quinone 251-258 inactive glutathione hydrolase 2 Homo sapiens 42-71 9871615-0 1998 Indolequinone antitumor agents: relationship between quinone structure and rate of metabolism by recombinant human NQO1. quinone 6-13 NAD(P)H quinone dehydrogenase 1 Homo sapiens 115-119 9367528-1 1997 Human NAD(P)H:quinone acceptor oxidoreductase-2 (NQO2) has been prepared using an Escherichia coli expression method. quinone 14-21 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 49-53 9310146-2 1997 Furthermore, the role of the quinone-reducing enzyme DT diaphorase [NAD(P)H:(quinone acceptor) oxidoreductase] was examined with respect to its influence on the genotoxic effects of model nitroaromatic pollutants. quinone 29-36 NAD(P)H quinone dehydrogenase 1 Homo sapiens 53-66 9343371-0 1997 The role of NAD(P)H:quinone oxidoreductase in quinone-mediated p21 induction in human colon carcinoma cells. quinone 20-27 cyclin dependent kinase inhibitor 1A Homo sapiens 63-66 9343371-17 1997 The metabolism of DZQ and AZQ in BE cells was associated with a significant increase of p21 mRNA levels; the former quinone was approximately 2-fold more efficient than the latter. quinone 116-123 cyclin dependent kinase inhibitor 1A Homo sapiens 88-91 9310146-5 1997 Despite these interspecific similarities, results revealed marked qualitative differences between the two species in terms of the influence of DT diaphorase on quinone-mediated genotoxicity. quinone 160-167 NAD(P)H quinone dehydrogenase 1 Homo sapiens 143-156 9266822-0 1997 Inhibition of the topoisomerase II-DNA cleavable complex by the ortho-quinone derivative of the antitumor drug etoposide (VP-16). quinone 70-77 host cell factor C1 Homo sapiens 122-127 9523739-5 1998 We also investigated the metabolism of the quinone moiety of geldanamycin by DT-diaphorase, an enzyme that activates certain quinone antibiotics such as mitomycin C and is hyperexpressed in colorectal cancer cells. quinone 43-50 NAD(P)H quinone dehydrogenase 1 Homo sapiens 77-90 9523739-5 1998 We also investigated the metabolism of the quinone moiety of geldanamycin by DT-diaphorase, an enzyme that activates certain quinone antibiotics such as mitomycin C and is hyperexpressed in colorectal cancer cells. quinone 125-132 NAD(P)H quinone dehydrogenase 1 Homo sapiens 77-90 9357549-7 1997 When compared with the non-enzyme protein, bovine serum albumin (BSA), SOD had a protective effect against BT, H2O2 and BLM; in the presence of GSH, SOD diminished the effect of HQ, BQ and Vit C but enhanced the effect of BT, H2O2 and BLM. quinone 182-184 superoxide dismutase 1 Homo sapiens 149-152 9357549-8 1997 With both GSH and Fe and compared with BSA, SOD enhanced the effect of HQ, BQ and BLM, ameliorated the effect of H2O2, and did not affect the others. quinone 75-77 superoxide dismutase 1 Homo sapiens 44-47 9461640-1 1997 Catalase was chemically modified by sodium chondroitin sulfate using the benzoquinone binding method. quinone 73-85 catalase Homo sapiens 0-8 9461640-3 1997 Treatment of catalase and superoxide dismutase with benzoquinone-activated chondroitin sulfate results in a bienzymic conjugate with electrophoretically heterogenous composition. quinone 52-64 catalase Homo sapiens 13-21 9251814-4 1997 The kinetic limitation of the photocycle was attributed to the turnover of the cytochrome c binding site (pH < 6), light intensity and quinone/quinol exchange (6 < pH < 8), and proton-coupled second electron transfer in the quinone acceptor complex (pH > 8). quinone 233-240 cytochrome c, somatic Homo sapiens 79-91 9310146-2 1997 Furthermore, the role of the quinone-reducing enzyme DT diaphorase [NAD(P)H:(quinone acceptor) oxidoreductase] was examined with respect to its influence on the genotoxic effects of model nitroaromatic pollutants. quinone 77-84 NAD(P)H quinone dehydrogenase 1 Homo sapiens 53-66 9214609-8 1997 The observation that obstruction of in vitro replication of COIII template bound to 3,4-EQ suggests that estrogen quinone adducted lesions can arrest DNA polymerase. quinone 114-121 mitochondrially encoded cytochrome c oxidase III Homo sapiens 60-65 27406966-5 1997 The concentration of the enzyme required for inhibition varied widely among the different compounds, and this was related to the autoxidation rate of the hydroquinone and the rate at which the corresponding quinone was reduced by diaphorase. quinone 159-166 dihydrolipoamide dehydrogenase Homo sapiens 230-240 9158692-4 1997 We have previously demonstrated that tyrosinase initially oxidizes hydroxychavicol (4-allyl-catechol) to an o-quinone (3,5-cyclohexadien-1,2-dione) which because of the relatively acidic protons in the benzyl position, readily isomerizes to the tautomeric p-quinone methide (4-allylidene-2,5-cyclohexadien-1-one, QM) (Bolton et al., 1994). quinone 256-265 tyrosinase Homo sapiens 37-47 9148761-1 1997 Rifampicin and its analogues, p-benzoquinone and hydroquinone, inhibited the toxicity of preformed aggregates of human islet amyloid polypeptide, amylin, to rat pheochromocytoma PC12 cells, when preincubated with the aggregated peptide before addition to cell cultures. quinone 30-44 islet amyloid polypeptide Homo sapiens 146-152 9105685-3 1997 The oxidation of the catecholamine to a quinone is greatly accelerated by the enzyme tyrosinase. quinone 40-47 tyrosinase Homo sapiens 85-95 9073589-0 1997 The cigarette tar component p-benzoquinone blocks T-lymphocyte activation by inhibiting interleukin-2 production, but not CD25, ICAM-1, or LFA-1 expression. quinone 30-42 interleukin 2 Homo sapiens 88-101 9073589-2 1997 We have shown that 10 microM p-benzoquinone (p-BQ), a thiol-reactive benzene derivative found in cigarette tar, inhibits mitogen-induced IL-2 production by human peripheral blood mononuclear cells by 76 +/- 7% without affecting lymphocyte/macrophage agglutination or blast transformation. quinone 29-43 interleukin 2 Homo sapiens 137-141 9073589-2 1997 We have shown that 10 microM p-benzoquinone (p-BQ), a thiol-reactive benzene derivative found in cigarette tar, inhibits mitogen-induced IL-2 production by human peripheral blood mononuclear cells by 76 +/- 7% without affecting lymphocyte/macrophage agglutination or blast transformation. quinone 45-49 interleukin 2 Homo sapiens 137-141 9073589-3 1997 The effect of p-BQ appeared to be specific for IL-2 production, since de novo induction of the IL-2 receptor alpha-chain (CD25) and ICAM-1 (CD54) and upregulation of LFA-1 alpha/beta (CD11a and CD18) were unaffected. quinone 14-18 interleukin 2 Homo sapiens 47-51 9073589-3 1997 The effect of p-BQ appeared to be specific for IL-2 production, since de novo induction of the IL-2 receptor alpha-chain (CD25) and ICAM-1 (CD54) and upregulation of LFA-1 alpha/beta (CD11a and CD18) were unaffected. quinone 14-18 interleukin 2 receptor subunit alpha Homo sapiens 95-114 9073589-3 1997 The effect of p-BQ appeared to be specific for IL-2 production, since de novo induction of the IL-2 receptor alpha-chain (CD25) and ICAM-1 (CD54) and upregulation of LFA-1 alpha/beta (CD11a and CD18) were unaffected. quinone 14-18 interleukin 2 receptor subunit alpha Homo sapiens 122-126 9177041-5 1997 CDH is only produced on cellulose or on wood, whereas pyranose oxidase and VAO are produced both on wood and on rich glucose media suggesting that the lignin degrading white-rot fungi may use different quinone and radical reducing enzymes to regulate lignin polymerization/depolymerization depending on the substrate and cultivation conditions. quinone 202-209 choline dehydrogenase Homo sapiens 0-3 9037558-3 1997 NQO1 is a cytosolic enzyme catalyzing the two-electron reduction of quinone substrates, which is thought to be involved in both metabolic activation and detoxification of carcinogenic agents that could be involved in lung carcinogenesis. quinone 68-75 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-4 9038241-0 1997 Activation of CGS 12094 (prinomide metabolite) to 1,4-benzoquinone by myeloperoxidase: implications for human idiosyncratic agranulocytosis. quinone 50-66 myeloperoxidase Homo sapiens 70-85 9118926-4 1996 A combination of metabolites (hydroquinone and phenol, for example) may be necessary to duplicate the hematotoxic effect of benzene, perhaps due in part to the synergistic effect of phenol on myeloperoxidase-mediated oxidation of hydroquinone to the reactive metabolite benzoquinone. quinone 270-282 myeloperoxidase Homo sapiens 192-207 9073589-3 1997 The effect of p-BQ appeared to be specific for IL-2 production, since de novo induction of the IL-2 receptor alpha-chain (CD25) and ICAM-1 (CD54) and upregulation of LFA-1 alpha/beta (CD11a and CD18) were unaffected. quinone 14-18 intercellular adhesion molecule 1 Homo sapiens 132-138 9073589-3 1997 The effect of p-BQ appeared to be specific for IL-2 production, since de novo induction of the IL-2 receptor alpha-chain (CD25) and ICAM-1 (CD54) and upregulation of LFA-1 alpha/beta (CD11a and CD18) were unaffected. quinone 14-18 intercellular adhesion molecule 1 Homo sapiens 140-144 9073589-3 1997 The effect of p-BQ appeared to be specific for IL-2 production, since de novo induction of the IL-2 receptor alpha-chain (CD25) and ICAM-1 (CD54) and upregulation of LFA-1 alpha/beta (CD11a and CD18) were unaffected. quinone 14-18 integrin subunit alpha L Homo sapiens 166-177 9073589-3 1997 The effect of p-BQ appeared to be specific for IL-2 production, since de novo induction of the IL-2 receptor alpha-chain (CD25) and ICAM-1 (CD54) and upregulation of LFA-1 alpha/beta (CD11a and CD18) were unaffected. quinone 14-18 integrin subunit alpha L Homo sapiens 178-189 9073589-3 1997 The effect of p-BQ appeared to be specific for IL-2 production, since de novo induction of the IL-2 receptor alpha-chain (CD25) and ICAM-1 (CD54) and upregulation of LFA-1 alpha/beta (CD11a and CD18) were unaffected. quinone 14-18 integrin subunit beta 2 Homo sapiens 194-198 9073589-5 1997 These results suggest that p-BQ inhibits T-cell mitogenesis by blocking a thiol-dependent event that controls IL-2 production but not other T-cell activation events. quinone 27-31 interleukin 2 Homo sapiens 110-114 9074802-5 1997 TPO-dependent product formation, characterized by on-line LC-APCI/MS and 1H-NMR, involved oxidative elimination to form the corresponding benzoquinone with subsequent dehydrogenation at the aliphatic 4-(dimethylamino) group. quinone 138-150 thyroid peroxidase Homo sapiens 0-3 8943236-15 1996 Hydrogen peroxide, a product of quinone redox cycling, elicited an increase of p21 mRNA levels in HCT116 and K562 human chronic myelogenous leukemia cells. quinone 32-39 cyclin dependent kinase inhibitor 1A Homo sapiens 79-82 8986133-1 1996 The enzyme DT-diaphorase (NAD(P)H:quinone acceptor oxidoreductase, EC 1.6.99.2.; DTD) is believed to be a good target for enzyme-directed bioreductive drug development because elevated levels of enzyme activity have been described in several human tumour types and it plays a key role in the bioreductive activation of several quinone-based anticancer drugs. quinone 34-41 NAD(P)H quinone dehydrogenase 1 Homo sapiens 11-24 11667879-5 1996 The observed NOE of the isolated product indicates clearly that the addition position of the amine is C-6 of the quinone. quinone 113-120 complement C6 Homo sapiens 102-105 8971136-3 1996 The heterologous expression of CYPOR in V79 cells resulted in increased sensitivity to quinone-type cytotoxins, e.g. duroquinone and menadione, that exert their toxicity primarily through the production of reactive oxygen species during redox cycling. quinone 87-94 cytochrome p450 oxidoreductase Homo sapiens 31-36 9118901-0 1996 p-Benzoquinone, a reactive metabolite of benzene, prevents the processing of pre-interleukins-1 alpha and -1 beta to active cytokines by inhibition of the processing enzymes, calpain, and interleukin-1 beta converting enzyme. quinone 0-14 caspase 1 Mus musculus 188-224 9118901-7 1996 Hydroquinone is oxidized by a peroxidase-mediated reaction in the stromal macrophage to p-benzoquinone, which interacts with the sulfhydryl (SH) groups of proteins and was shown to completely inhibit the activity of calpain, the SH-dependent protease that cleaves pre-IL-1 alpha. quinone 88-102 interleukin 1 alpha Mus musculus 268-278 9118901-8 1996 In a similar manner, HQ, via peroxidase oxidation to p-benzoquinone, was capable of preventing the IL-1 beta autocrine stimulation of growth of human B1 myeloid tumor cells by preventing the processing of pre-IL-1 beta to mature cytokine. quinone 53-67 interleukin 1 beta Homo sapiens 99-108 9118901-8 1996 In a similar manner, HQ, via peroxidase oxidation to p-benzoquinone, was capable of preventing the IL-1 beta autocrine stimulation of growth of human B1 myeloid tumor cells by preventing the processing of pre-IL-1 beta to mature cytokine. quinone 53-67 interleukin 1 beta Homo sapiens 209-218 9118901-9 1996 Benzoquinone was also shown to completely inhibit the ability of the SH-dependent IL-1 beta converting enzyme. quinone 0-12 interleukin 1 beta Homo sapiens 82-91 8906816-3 1996 Capsaicin (8-methyl-N-vanillyl-6-nonenamide) is a quinone that has been shown to regulate a wide variety of activities that require NF-kappa B activation. quinone 50-57 nuclear factor kappa B subunit 1 Homo sapiens 132-142 8948030-7 1996 Hydroquinone inhibition of apoptosis in myeloblasts, like hydroquinone-induced granulocytic differentiation, required myeloperoxidase-mediated oxidation of hydroquinone to its reactive species, p-benzoquinone, and was inhibited 50% by the peroxidase inhibitor, indomethacin (20 microM). quinone 194-208 myeloperoxidase Mus musculus 118-133 8948030-8 1996 p-benzoquinone (3 microM) was shown to cause a 50% inhibition of CPP32, an IL-1 beta-converting enzyme/Ced-3 cysteine protease involved in the implementation of apoptosis and present in myeloid cells. quinone 0-14 caspase 3 Mus musculus 65-70 8638949-4 1996 Tyrosinase readily oxidized this unusual amino acid to the expected quinone. quinone 68-75 tyrosinase Homo sapiens 0-10 8863816-1 1996 Previous studies have indicated that NAD(P)H: quinone oxidoreductase [DT-diaphorase (NQO1)] plays an important role in the bioreductive activation of quinone-containing antitumor agents. quinone 46-53 NAD(P)H quinone dehydrogenase 1 Homo sapiens 70-83 8863816-1 1996 Previous studies have indicated that NAD(P)H: quinone oxidoreductase [DT-diaphorase (NQO1)] plays an important role in the bioreductive activation of quinone-containing antitumor agents. quinone 46-53 NAD(P)H quinone dehydrogenase 1 Homo sapiens 85-89 9118895-7 1996 Destruction of CYP in vitro caused by HQ or BQ was not mediated by hydroxyl radical formation or by lipid peroxidation. quinone 44-46 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 Rattus norvegicus 15-18 8694255-5 1996 The quinone is reconverted to catechol by glucose dehydrogenase. quinone 4-11 hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase Homo sapiens 42-63 8842692-4 1996 Only p-benzoquinone and 2,5-dimethyl-p-benzoquinone inhibited Ca2+ ATPase activity in a time-and concentration-dependent way, tetramethyl-1,4-benzoquinone being ineffective. quinone 5-19 carbonic anhydrase 2 Homo sapiens 62-73 8657209-0 1996 Influence of DT diaphorase on quinone-mediated genotoxicity in human and fish cell lines. quinone 30-37 NAD(P)H quinone dehydrogenase 1 Homo sapiens 13-26 8657209-1 1996 The influence of the quinone-reducing enzyme, DT diaphorase [NAD(P)H: (quinone acceptor) oxidoreductase], on the genotoxicity of quinones was examined in two cell lines, namely a human hepatoma cell line, HepG2 and a brown bullhead fibroblast cell line, BB. quinone 21-28 NAD(P)H quinone dehydrogenase 1 Homo sapiens 46-59 8657209-1 1996 The influence of the quinone-reducing enzyme, DT diaphorase [NAD(P)H: (quinone acceptor) oxidoreductase], on the genotoxicity of quinones was examined in two cell lines, namely a human hepatoma cell line, HepG2 and a brown bullhead fibroblast cell line, BB. quinone 21-28 thioredoxin reductase 1 Homo sapiens 89-104 8657209-5 1996 Despite these similarities, results revealed marked qualitative differences between the two species in terms of the influence of DT diaphorase on quinone-mediated genotoxicity. quinone 146-153 NAD(P)H quinone dehydrogenase 1 Homo sapiens 129-142 8653808-0 1996 Quinone-induced apoptosis in human colon adenocarcinoma cells via DT-diaphorase mediated bioactivation. quinone 0-7 NAD(P)H quinone dehydrogenase 1 Homo sapiens 66-79 8622636-0 1996 Inhibitory effect of E3330, a novel quinone derivative able to suppress tumor necrosis factor-alpha generation, on activation of nuclear factor-kappa B. quinone 36-43 tumor necrosis factor Homo sapiens 72-99 8728511-9 1996 Higher levels of the semiquinone adducts were observed in Hb than in Alb, in contrast to the results with the quinone adducts. quinone 25-32 albumin Rattus norvegicus 69-72 8643080-12 1996 Addition of human myeloperoxidase to the HQ/Cu/Zn-SOD synergistically enhanced the formation of BQ from HQ. quinone 96-98 myeloperoxidase Homo sapiens 18-33 8652659-2 1996 We show that the ARE (TGACNNNGCA) is required for induction by redox cycling phenolics (p-benzoquinone, catechol and hydroquinone), which are monofunctional inducers and induce NQO1 without the requirement for activation by cytochrome P-450. quinone 88-102 NAD(P)H quinone dehydrogenase 1 Homo sapiens 177-181 8615688-5 1996 In the presence of the 17beta-hydroxysteroid dehydrogenase, the equilibrium between 17beta-estradiol, estrone, NADP, and NADPH is shifted by 7,8-benzo[a]pyrenequinone because the rapid redox cycling of this quinone results in the oxidation of NADPH. quinone 159-166 hydroxysteroid 17-beta dehydrogenase 7 Homo sapiens 23-58 8617772-3 1996 In the same cells, a biologically active benzoquinone photoaffinity label specifically binds a protein of about 100 kDa, and the ability of various GA derivatives to reduce the intracellular level of p185erbB2 correlates with their ability to compete with the photoaffinity label for binding to this protein. quinone 41-53 erb-b2 receptor tyrosine kinase 2 Homo sapiens 200-209 8630269-1 1996 Sublethal quinone-mediated oxidative stress stimulates increases in the activities and mRNA levels of gamma-glutamyl transpeptidase (GGT) and gamma-glutamylcysteine synthetase (GCS) in rat lung epithelial L2 cells [Kugelman, A. et al. quinone 10-17 gamma-glutamyltransferase 1 Rattus norvegicus 102-131 8630269-1 1996 Sublethal quinone-mediated oxidative stress stimulates increases in the activities and mRNA levels of gamma-glutamyl transpeptidase (GGT) and gamma-glutamylcysteine synthetase (GCS) in rat lung epithelial L2 cells [Kugelman, A. et al. quinone 10-17 gamma-glutamyltransferase 1 Rattus norvegicus 133-136 8630269-1 1996 Sublethal quinone-mediated oxidative stress stimulates increases in the activities and mRNA levels of gamma-glutamyl transpeptidase (GGT) and gamma-glutamylcysteine synthetase (GCS) in rat lung epithelial L2 cells [Kugelman, A. et al. quinone 10-17 glutamate-cysteine ligase, catalytic subunit Rattus norvegicus 142-175 8630269-1 1996 Sublethal quinone-mediated oxidative stress stimulates increases in the activities and mRNA levels of gamma-glutamyl transpeptidase (GGT) and gamma-glutamylcysteine synthetase (GCS) in rat lung epithelial L2 cells [Kugelman, A. et al. quinone 10-17 glutamate-cysteine ligase, catalytic subunit Rattus norvegicus 177-180 8630270-0 1996 Increased gamma-glutamylcysteine synthetase and gamma-glutamyl transpeptidase activities enhance resistance of rat lung epithelial L2 cells to quinone toxicity. quinone 143-150 glutamate-cysteine ligase, catalytic subunit Rattus norvegicus 10-43 8630270-0 1996 Increased gamma-glutamylcysteine synthetase and gamma-glutamyl transpeptidase activities enhance resistance of rat lung epithelial L2 cells to quinone toxicity. quinone 143-150 gamma-glutamyltransferase 1 Rattus norvegicus 48-77 8630270-9 1996 The results suggest that elevation of GCS and GGT activities participated in acquired resistance to quinone toxicity. quinone 100-107 glutamate-cysteine ligase, catalytic subunit Rattus norvegicus 38-41 8630270-9 1996 The results suggest that elevation of GCS and GGT activities participated in acquired resistance to quinone toxicity. quinone 100-107 gamma-glutamyltransferase 1 Rattus norvegicus 46-49 8579568-5 1996 The catalytic center activity (Kcat) values indicated that camel zeta-crystallin catalyzed the reduction of PAQ more efficiently than the guinea pig lens zeta-crystallin, although the Km values of the two enzymes for this quinone were very similar. quinone 222-229 quinone oxidoreductase Cavia porcellus 65-80 8579568-5 1996 The catalytic center activity (Kcat) values indicated that camel zeta-crystallin catalyzed the reduction of PAQ more efficiently than the guinea pig lens zeta-crystallin, although the Km values of the two enzymes for this quinone were very similar. quinone 222-229 quinone oxidoreductase Cavia porcellus 154-169 8643079-4 1996 The acceleration of autoxidation of HQ by Cu/Zn-SOD results in the production of 1,4-benzoquinone (BQ). quinone 81-97 superoxide dismutase 1 Homo sapiens 42-51 8643079-4 1996 The acceleration of autoxidation of HQ by Cu/Zn-SOD results in the production of 1,4-benzoquinone (BQ). quinone 99-101 superoxide dismutase 1 Homo sapiens 42-51 8643079-8 1996 In phosphate-buffered saline (PSB), HQ underwent a slow autoxidation to BQ, which was accelerated by Cu/Zn-SOD, Mn-SOD, or Fe-SOD with similar efficiency. quinone 72-74 superoxide dismutase 1 Homo sapiens 101-110 8643079-8 1996 In phosphate-buffered saline (PSB), HQ underwent a slow autoxidation to BQ, which was accelerated by Cu/Zn-SOD, Mn-SOD, or Fe-SOD with similar efficiency. quinone 72-74 superoxide dismutase 2 Homo sapiens 112-118 8643079-8 1996 In phosphate-buffered saline (PSB), HQ underwent a slow autoxidation to BQ, which was accelerated by Cu/Zn-SOD, Mn-SOD, or Fe-SOD with similar efficiency. quinone 72-74 superoxide dismutase 1 Homo sapiens 107-110 8643080-3 1996 Cu/Zn-superoxide dismutase (SOD)-accelerated oxidation of the benzene metabolite 1,4-hydroquinone (HQ) results in the enhanced formation of semiquinone anion radicals, electrophilic 1,4-benzoquinone (BQ), and H202. quinone 182-198 superoxide dismutase 1 Homo sapiens 0-26 8643080-3 1996 Cu/Zn-superoxide dismutase (SOD)-accelerated oxidation of the benzene metabolite 1,4-hydroquinone (HQ) results in the enhanced formation of semiquinone anion radicals, electrophilic 1,4-benzoquinone (BQ), and H202. quinone 182-198 superoxide dismutase 1 Homo sapiens 28-31 8643080-3 1996 Cu/Zn-superoxide dismutase (SOD)-accelerated oxidation of the benzene metabolite 1,4-hydroquinone (HQ) results in the enhanced formation of semiquinone anion radicals, electrophilic 1,4-benzoquinone (BQ), and H202. quinone 200-202 superoxide dismutase 1 Homo sapiens 0-26 8643080-3 1996 Cu/Zn-superoxide dismutase (SOD)-accelerated oxidation of the benzene metabolite 1,4-hydroquinone (HQ) results in the enhanced formation of semiquinone anion radicals, electrophilic 1,4-benzoquinone (BQ), and H202. quinone 200-202 superoxide dismutase 1 Homo sapiens 28-31 8643080-12 1996 Addition of human myeloperoxidase to the HQ/Cu/Zn-SOD synergistically enhanced the formation of BQ from HQ. quinone 96-98 superoxide dismutase 1 Homo sapiens 50-53 8643080-17 1996 The H202 generated from the Cu/Zn-SOD-accelerated oxidation of HQ can also be utilized by myeloperoxidase resulting in additional conversion of HQ to BQ. quinone 150-152 superoxide dismutase 1 Homo sapiens 34-37 8643080-17 1996 The H202 generated from the Cu/Zn-SOD-accelerated oxidation of HQ can also be utilized by myeloperoxidase resulting in additional conversion of HQ to BQ. quinone 150-152 myeloperoxidase Homo sapiens 90-105 8748931-5 1995 The nephrotoxicity of hydroquinone and bromobenzene is mediated via quinone - glutathione conjugates, and is manifested in cellular changes, including induction of the gadd-153 and hsp-70 mRNA. quinone 27-34 DNA-damage inducible transcript 3 Rattus norvegicus 168-176 8573194-5 1996 SOD also inhibited the rate of quinol oxidation by oxygen, after quinone reduction by a stoichiometric amount of DHLA. quinone 65-72 superoxide dismutase 1 Homo sapiens 0-3 9010585-7 1996 CYP2E1 oxidizing benzene via phenol to 1,4-hydroquinone appeared to mediate its further oxidation to 1,4-benzoquinone, which also occurred spontaneously, but was reversed in a reducing environment of microsomes with NADPH. quinone 101-117 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 0-6 8689238-0 1996 Inhibition of aldose reductase by maesanin and related p-benzoquinone derivatives and effects on other enzymes. quinone 57-69 aldo-keto reductase family 1 member B Homo sapiens 14-30 8689238-1 1996 A naturally occurring p-benzoquinone derivative, maesanin, inhibited porcine lens aldose reductase. quinone 22-36 aldo-keto reductase family 1 member B Homo sapiens 82-98 8689238-2 1996 Systematic investigation of related p-benzoquinone derivatives revealed that 2,5-dihydroxy-p-benzoquinone was a potent inhibitor of aldose reductase and aldehyde reductase but had no effect on NADH oxidase. quinone 36-50 aldo-keto reductase family 1 member B Homo sapiens 132-148 8689238-2 1996 Systematic investigation of related p-benzoquinone derivatives revealed that 2,5-dihydroxy-p-benzoquinone was a potent inhibitor of aldose reductase and aldehyde reductase but had no effect on NADH oxidase. quinone 36-50 aldo-keto reductase family 1 member A1 Homo sapiens 153-171 8543588-3 1996 We previously reported that the MMC-resistant cell line (PC-9/MC4) was poor in NAD(P)H dehydrogenase (quinone) activity and approximately 6-fold more resistant than the parent cells (PC-9) to MMC on 2-h exposure under aerobic conditions. quinone 102-109 proprotein convertase subtilisin/kexin type 9 Homo sapiens 57-61 8548860-10 1995 These findings support our observations in a mouse model that benzene-induced bone marrow cell depression results from a lack of interleukin-1 alpha subsequent to an inhibition by benzoquinone of calpain, the protease required for converting pre-interleukin-1 alpha to active cytokine. quinone 180-192 interleukin 1 alpha Mus musculus 246-265 8534672-6 1995 capsulatus, the energetic behaviour of the quinone complex of R. gelatinosus appears to be somewhat different: (i) above pH 10, kAP decreases, whereas it increases in Rps. quinone 43-50 napsin A aspartic peptidase Homo sapiens 128-131 8597083-1 1995 In this study, overexpression of the cDNA for the major cytoplasmic glutathione peroxidase isoenzyme, GSH Peroxidase 1 (GSHPx-1), in human MCF-7 breast cancer cells has been shown to significantly increase the tolerance of these cells to oxidative stress produced by hydrogen peroxide or by the redox cycling of the quinone-containing anticancer agent doxorubicin. quinone 316-323 glutathione peroxidase 1 Homo sapiens 102-118 8597083-1 1995 In this study, overexpression of the cDNA for the major cytoplasmic glutathione peroxidase isoenzyme, GSH Peroxidase 1 (GSHPx-1), in human MCF-7 breast cancer cells has been shown to significantly increase the tolerance of these cells to oxidative stress produced by hydrogen peroxide or by the redox cycling of the quinone-containing anticancer agent doxorubicin. quinone 316-323 glutathione peroxidase 1 Homo sapiens 120-127 9139360-4 1995 The nucleotide sequences of cytochrome b gene at Qi/quinone binding site from both stages were analyzed using thermal cycle sequencing and were found to be the same. quinone 52-59 mitochondrially encoded cytochrome b Homo sapiens 28-40 8573592-4 1996 Synthetic capsaicin analogues inhibited all three NDH-1 activities in a competitive manner against an exogenous quinone. quinone 112-119 NADH dehydrogenase subunit 1 Solanum tuberosum 50-55 8933618-7 1996 Studies with the highly specific LTD4 receptor antagonist, MK-571, suggest that BQ induces granulocytic differentiation in myeloblasts by activating the LTD4 receptor, thus obviating the requirement for LTD4. quinone 80-82 cysteinyl leukotriene receptor 1 Mus musculus 33-46 8933618-7 1996 Studies with the highly specific LTD4 receptor antagonist, MK-571, suggest that BQ induces granulocytic differentiation in myeloblasts by activating the LTD4 receptor, thus obviating the requirement for LTD4. quinone 80-82 cysteinyl leukotriene receptor 1 Mus musculus 153-166 9015862-4 1996 We have previously shown that hydroquinone (HQ), via conversion to bioreactive p-benzoquinone (BQ), causes neutrophilia in mice and induces granulocytic differentiation in myeloblasts through interaction with the leukotriene D4 (LTD4) receptor. quinone 79-93 cysteinyl leukotriene receptor 1 Mus musculus 213-243 9015862-4 1996 We have previously shown that hydroquinone (HQ), via conversion to bioreactive p-benzoquinone (BQ), causes neutrophilia in mice and induces granulocytic differentiation in myeloblasts through interaction with the leukotriene D4 (LTD4) receptor. quinone 95-97 cysteinyl leukotriene receptor 1 Mus musculus 213-243 8748931-5 1995 The nephrotoxicity of hydroquinone and bromobenzene is mediated via quinone - glutathione conjugates, and is manifested in cellular changes, including induction of the gadd-153 and hsp-70 mRNA. quinone 27-34 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 181-187 7677784-1 1995 It is generally accepted that DT-diaphorase is primarily involved in the detoxification of quinone compounds and is capable of metabolically activating some cancer chemotherapeutic quinones including mitomycin C. quinone 91-98 NAD(P)H dehydrogenase, quinone 1 Mus musculus 30-43 7677784-5 1995 These mutant cell lines seem to be very useful for investigating the functions of DT-diaphorase including the bioactivation and detoxification of quinone species. quinone 146-153 NAD(P)H dehydrogenase, quinone 1 Mus musculus 82-95 7744305-3 1995 Acetylcholinesterase selectively inhibited the speed of quinone production from dopamine as well as accumulation of hydrogen peroxide, whilst the rate of generation of superoxide was increased. quinone 56-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 8571360-3 1995 A combination of metabolites (hydroquinone and phenol for example) is apparently necessary to duplicate the hematotoxic effect of benzene, perhaps due in part to the synergistic effect of phenol on myeloperoxidase-mediated oxidation of hydroquinone to the reactive metabolite benzoquinone. quinone 276-288 myeloperoxidase Homo sapiens 198-213 7565631-0 1995 Nicotinamide adenine dinucleotide (phosphate): quinone oxidoreductase (DT-diaphorase) as a target for bioreductive antitumor quinones: quinone cytotoxicity and selectivity in human lung and breast cancer cell lines. quinone 47-54 NAD(P)H quinone dehydrogenase 1 Homo sapiens 71-84 7639539-1 1995 NAD(P)H: quinone-acceptor oxidoreductase (EC 1.6.99.2), also referred to as DT-diaphorase, is a flavoprotein that catalyzes the two-electron reduction of quinones and quinonoid compounds to hydroquinones, using either NADH or NADPH as the electron donor. quinone 9-16 NAD(P)H quinone dehydrogenase 1 Homo sapiens 76-89 20650112-4 1995 In KG-1 and U937 cells, CYP1 Al mRNA induction was studied in the presence of the benzene metabolites, hydroquinone (HQ), p-benzoquinone (BQ), phenol (PHE) and catechol (CAT). quinone 122-136 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 24-28 7780966-0 1995 An alternatively spliced form of NQO1 (DT-diaphorase) messenger RNA lacking the putative quinone substrate binding site is present in human normal and tumor tissues. quinone 89-96 NAD(P)H quinone dehydrogenase 1 Homo sapiens 33-37 7780966-0 1995 An alternatively spliced form of NQO1 (DT-diaphorase) messenger RNA lacking the putative quinone substrate binding site is present in human normal and tumor tissues. quinone 89-96 NAD(P)H quinone dehydrogenase 1 Homo sapiens 39-52 7780966-1 1995 DT-diaphorase is a ubiquitously expressed flavoenzyme responsible for the two-electron reduction of a number of quinone and other anticancer drugs. quinone 112-119 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-13 7780966-4 1995 Exon 4 codes for the putative quinone substrate binding site of DT-diaphorase derived from NQO1 and the recombinant protein from alternatively spliced NQO1 mRNA lacking exon 4 has minimal enzyme activity with quinoid and other known substrates of DT-diaphorase. quinone 30-37 NAD(P)H quinone dehydrogenase 1 Homo sapiens 64-77 7780966-4 1995 Exon 4 codes for the putative quinone substrate binding site of DT-diaphorase derived from NQO1 and the recombinant protein from alternatively spliced NQO1 mRNA lacking exon 4 has minimal enzyme activity with quinoid and other known substrates of DT-diaphorase. quinone 30-37 NAD(P)H quinone dehydrogenase 1 Homo sapiens 91-95 7780966-4 1995 Exon 4 codes for the putative quinone substrate binding site of DT-diaphorase derived from NQO1 and the recombinant protein from alternatively spliced NQO1 mRNA lacking exon 4 has minimal enzyme activity with quinoid and other known substrates of DT-diaphorase. quinone 30-37 NAD(P)H quinone dehydrogenase 1 Homo sapiens 151-155 7819227-0 1995 Role of quinone-mediated generation of hydroxyl radicals in the induction of glutathione S-transferase gene expression. quinone 8-15 glutathione S-transferase kappa 1 Homo sapiens 77-102 7601275-1 1995 The axial ligands of low potential cytochrome b560 in the five subunit bovine heart succinate-ubiquinone reductase complex and in the isolated quinone binding proteins have been investigated using EPR and near-infrared magnetic circular dichroism spectroscopies. quinone 97-104 cytochrome b Bos taurus 35-47 7746280-1 1995 NAD(P):quinone acceptor oxidoreductase (quinone reductase) (DT-diaphorase, EC 1.6.99.2) is involved in the process of reductive activation of cytotoxic antitumor quinones and nitrobenzenes. quinone 7-14 crystallin, zeta Mus musculus 40-57 7746280-1 1995 NAD(P):quinone acceptor oxidoreductase (quinone reductase) (DT-diaphorase, EC 1.6.99.2) is involved in the process of reductive activation of cytotoxic antitumor quinones and nitrobenzenes. quinone 7-14 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 60-73 7733672-1 1995 Following the two-electron reduction of 2-methyl-1,4-naphthoquinone by rat liver DT-diaphorase (also called NAD(P)H: (quinone acceptor) oxidoreductase, EC 1.6.99.2), the hydroquinone product is slowly autoxidized to the quinone in buffered solutions at pH 7.0. quinone 60-67 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 81-94 7733672-1 1995 Following the two-electron reduction of 2-methyl-1,4-naphthoquinone by rat liver DT-diaphorase (also called NAD(P)H: (quinone acceptor) oxidoreductase, EC 1.6.99.2), the hydroquinone product is slowly autoxidized to the quinone in buffered solutions at pH 7.0. quinone 118-125 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 81-94 9101243-4 1995 (c) NADPH-cytochrome P450 reductase-catalyzed activation of products resulting from the quinone/GSH interaction. quinone 88-95 cytochrome p450 oxidoreductase Homo sapiens 4-35 7603972-1 1995 An NAD(P)H:(quinone acceptor) oxidoreductase (EC 1.6.99.2) was purified from Glycine max seedlings by means of chromatographic procedures. quinone 12-19 putative NADH-dependent hydroxypyruvate reductase Glycine max 30-44 8572925-2 1995 NAD(P)H:quinone reductase (QR) is known to protect against BQ toxicity. quinone 59-61 crystallin zeta Homo sapiens 0-25 8572925-0 1995 Aspirin-like drugs can protect human T lymphocytes against benzoquinone cytotoxicity: evidence for a NAD(P)H:quinone reductase-dependent mechanism. quinone 59-71 crystallin zeta Homo sapiens 101-126 8572925-2 1995 NAD(P)H:quinone reductase (QR) is known to protect against BQ toxicity. quinone 59-61 crystallin zeta Homo sapiens 27-29 8572925-5 1995 It was therefore hypothesized that ALD would protect lymphocytes against BQ toxicity by inducing QR. quinone 73-75 crystallin zeta Homo sapiens 97-99 8572925-9 1995 ALDs induced QR activity in the M4 cells in the same range of concentrations that protected the cells against BQ toxicity. quinone 110-112 crystallin zeta Homo sapiens 13-15 7989327-7 1994 This conclusion is confirmed by the results, which indicate that pi-ADH very efficiently catalyzes the reduction of BQI and 1,4-benzoquinone (BQ) to the corresponding hydroquinones. quinone 124-140 alcohol dehydrogenase 1A (class I), alpha polypeptide Homo sapiens 68-71 7899491-0 1995 Quinone binding sites on cytochrome b/c complexes. quinone 0-7 mitochondrially encoded cytochrome b Homo sapiens 25-37 8584672-6 1995 The organic cofactor in all three enzyme types is a quinone; however, the spectral features of phenylhydrazine and p-nitrophenylhydrazine-derivatized SSAO differ from those reported for all known topaquinone-containing enzymes. quinone 52-59 amine oxidase copper containing 3 Homo sapiens 150-154 7989327-7 1994 This conclusion is confirmed by the results, which indicate that pi-ADH very efficiently catalyzes the reduction of BQI and 1,4-benzoquinone (BQ) to the corresponding hydroquinones. quinone 116-118 alcohol dehydrogenase 1A (class I), alpha polypeptide Homo sapiens 68-71 7974500-10 1994 Inhibition of GM-CSF-induced responses by BQ correlated closely with cytotoxicity, and DX was 1000-fold more inhibitory to GM-CSF-induced proliferative and colony-forming responses than either HQ or BQ. quinone 42-44 colony stimulating factor 2 Homo sapiens 14-20 7530954-0 1995 Antioxidant and prooxidant functions of DT-diaphorase in quinone metabolism. quinone 57-64 NAD(P)H quinone dehydrogenase 1 Homo sapiens 40-53 7974500-13 1994 Inhibition of GM-CSF-induced HPC responses by HQ, BQ, and DX was very similar to that obtained when BM mononuclear cells were used, suggesting that the human HPC is a target for the direct effects of HQ, BQ, and DX. quinone 50-52 colony stimulating factor 2 Homo sapiens 14-20 7974500-13 1994 Inhibition of GM-CSF-induced HPC responses by HQ, BQ, and DX was very similar to that obtained when BM mononuclear cells were used, suggesting that the human HPC is a target for the direct effects of HQ, BQ, and DX. quinone 204-206 colony stimulating factor 2 Homo sapiens 14-20 7929374-0 1994 Quinone-induced oxidative stress elevates glutathione and induces gamma-glutamylcysteine synthetase activity in rat lung epithelial L2 cells. quinone 0-7 glutamate-cysteine ligase, catalytic subunit Rattus norvegicus 66-99 7955076-3 1994 Studies in rodents indicate that certain enzymes of this battery, namely cytochrome P4501A1 (CYP1A1), UDP-glucuronosyltransferase (UGT1*06) and NAD(P)H: quinone acceptor oxidoreductase (NMO1) are induced by the synthetic antioxidant 5,10-dihydroindeno[1,2-b]indole (DHII). quinone 153-160 NAD(P)H dehydrogenase, quinone 1 Mus musculus 186-190 7961719-11 1994 These results indicate that the binding environment of the benzoquinone ring in succinate-Q reductase is more specific than that of ubiquinol-cytochrome c reductase. quinone 59-71 LOC104968582 Bos taurus 142-154 8033096-1 1994 NAD(P)H:quinone acceptor oxidoreductase (NQO1, EC 1.6.99.2) is an enzyme that is believed to play a central role in the bioreductive activation of several compounds, particularly quinones. quinone 8-15 thioredoxin reductase 1 Homo sapiens 25-39 8033096-1 1994 NAD(P)H:quinone acceptor oxidoreductase (NQO1, EC 1.6.99.2) is an enzyme that is believed to play a central role in the bioreductive activation of several compounds, particularly quinones. quinone 8-15 NAD(P)H quinone dehydrogenase 1 Homo sapiens 41-45 8037673-1 1994 The one- and two-electron enzymic reduction of the bioreductive alkylating agents 2-methylmethoxynaphthoquinone (quinone I) and 2-chloromethylnaphthoquinone (quinone II) was studied with purified NADPH-cytochrome P-450 reductase and DT-diaphorase respectively, and characterized in terms of kinetic constants, oxyradical production, thiol oxidation and DNA-strand-break formation. quinone 104-111 cytochrome p450 oxidoreductase Bos taurus 196-228 8037673-1 1994 The one- and two-electron enzymic reduction of the bioreductive alkylating agents 2-methylmethoxynaphthoquinone (quinone I) and 2-chloromethylnaphthoquinone (quinone II) was studied with purified NADPH-cytochrome P-450 reductase and DT-diaphorase respectively, and characterized in terms of kinetic constants, oxyradical production, thiol oxidation and DNA-strand-break formation. quinone 113-120 cytochrome p450 oxidoreductase Bos taurus 196-228 8037673-2 1994 The catalytic-centre activity values indicated that DT-diaphorase catalysed the reduction of quinone I far more efficiently than NADPH-cytochrome P-450 reductase, although the Km values of the two enzymes for this quinone were similar (1.2-3.0 microM). quinone 214-221 cytochrome p450 oxidoreductase Bos taurus 129-161 8031317-3 1994 In this paper we followed the ability of benzene and its metabolites, phenol, catechol, hydroquinone and benzoquinone to destroy CYP in liver microsomes from PB rats in vitro. quinone 105-117 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 129-132 8031317-5 1994 (2) Quinonic metabolites of benzene cause CYP destruction with different potency (30% CYP was destroyed by 3 mM catechol, 0.3 mM hydroquinone and 0.03 mM benzoquinone). quinone 154-166 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 42-45 8031317-5 1994 (2) Quinonic metabolites of benzene cause CYP destruction with different potency (30% CYP was destroyed by 3 mM catechol, 0.3 mM hydroquinone and 0.03 mM benzoquinone). quinone 154-166 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 86-89 8031317-9 1994 (6) CYP activities differ in the sensitivity to quinone-mediated destruction. quinone 48-55 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 4-7 8061594-1 1994 Over 145 extracts of vegetables, fruits, herbs, spices and beverages which are consumed regularly in the European diet have been surveyed for potential anti-carcinogenic activity using an assay which measures the induction of NAD(P)H: (quinone acceptor) menadione oxidoreductase (quinone reductase, QR) activity in murine cells challenged with solutions of potential inducers. quinone 236-243 crystallin, zeta Mus musculus 280-297 8209375-15 1994 Our findings suggest that a mechanism for inhibition of Fc receptor-mediated phagocytosis by BQ is disruption of filamentous actin via an effect(s) other than the direct alkylation of actin by BQ. quinone 93-95 Fc receptor Mus musculus 56-67 8209375-15 1994 Our findings suggest that a mechanism for inhibition of Fc receptor-mediated phagocytosis by BQ is disruption of filamentous actin via an effect(s) other than the direct alkylation of actin by BQ. quinone 193-195 Fc receptor Mus musculus 56-67 8200081-0 1994 Quinone methide mediates in vitro induction of ornithine decarboxylase by the tumor promoter butylated hydroxytoluene hydroperoxide. quinone 0-7 ornithine decarboxylase 1 Homo sapiens 47-70 8313954-10 1994 Cytochrome b residues in 33 and in 221 seemed to contribute to the quinone reduction (QN) site of the cytochrome bc1 complex. quinone 67-74 cytochrome b Saccharomyces cerevisiae S288C 0-12 16349169-6 1994 In the first step the tyrosinase enzyme was used to selectively convert the p-hydroxyphenoxyacetate contaminant to a reactive intermediate-presumably its quinone. quinone 154-161 tyrosinase Homo sapiens 22-32 8291054-2 1994 Benzene myelotoxicity, reproduced by coadministering phenol (PH) and hydroquinone (HQ) but not when these benzene metabolites were administered alone, has been postulated to be induced by PH stimulating the myeloperoxidase-mediated oxidation of HQ to the toxic 1,4-benzoquinone in bone marrow. quinone 261-277 myeloperoxidase Mus musculus 207-222 8305435-11 1994 These results indicate that the binding environment of the benzoquinone ring in succinate-Q reductase is very specific and differs from that in ubiquinol-cytochrome c reductase. quinone 59-71 LOC104968582 Bos taurus 154-166 8123686-5 1994 The reaction as catalyzed by purified AACT/HMGS is strongly stimulated in vitro in presence of FeII-chelates (namely EDTA) and of quinone cofactors with pyrroloquinoline quinone (PQQ) being by far the most effective one studied so far. quinone 130-137 acetyl-CoA acetyltransferase, cytosolic 1 Raphanus sativus 38-42 8123686-5 1994 The reaction as catalyzed by purified AACT/HMGS is strongly stimulated in vitro in presence of FeII-chelates (namely EDTA) and of quinone cofactors with pyrroloquinoline quinone (PQQ) being by far the most effective one studied so far. quinone 130-137 hydroxymethylglutaryl-CoA synthase Saccharomyces cerevisiae S288C 43-47 7620214-0 1994 Enzyme-directed bioreductive drug development revisited: a commentary on recent progress and future prospects with emphasis on quinone anticancer agents and quinone metabolizing enzymes, particularly DT-diaphorase. quinone 127-134 NAD(P)H quinone dehydrogenase 1 Homo sapiens 200-213 7620214-0 1994 Enzyme-directed bioreductive drug development revisited: a commentary on recent progress and future prospects with emphasis on quinone anticancer agents and quinone metabolizing enzymes, particularly DT-diaphorase. quinone 157-164 NAD(P)H quinone dehydrogenase 1 Homo sapiens 200-213 7620214-5 1994 In this commentary, recent progress in the area of enzyme-directed bioreductive drug development is reviewed with emphasis on quinone anticancer agents and quinone reducing enzymes, particularly DT-diaphorase, which is often hyperexpressed in cancer tissue. quinone 126-133 NAD(P)H quinone dehydrogenase 1 Homo sapiens 195-208 7620214-5 1994 In this commentary, recent progress in the area of enzyme-directed bioreductive drug development is reviewed with emphasis on quinone anticancer agents and quinone reducing enzymes, particularly DT-diaphorase, which is often hyperexpressed in cancer tissue. quinone 156-163 NAD(P)H quinone dehydrogenase 1 Homo sapiens 195-208 8288159-7 1993 It is postulated that both iodoacetamide and a thyroxine-derived oxidation product (presumably a quinone) alkylate sulphydryl groups near the active centre of myeloperoxidase making it more accessible for its substrate. quinone 97-104 myeloperoxidase Homo sapiens 159-174 8248195-1 1993 A quinone-independent photoreduction of the low potential form of cytochrome b559 has been studied using isolated reaction centers of photosystem II. quinone 2-9 mitochondrially encoded cytochrome b Homo sapiens 66-78 8403220-0 1993 Measurement of adducts of benzoquinone with hemoglobin and albumin. quinone 26-38 albumin Homo sapiens 59-66 7685581-3 1993 In a buffer containing 1% albumin and 10 microM quinone, 9,10-phenanthrenequinone is reduced most rapidly by the carbonyl reductase, 2-methyl-1,4-naphthoquinone is reduced most rapidly by the rat enzyme, and 3,6-pyrenequinone is reduced most rapidly by the Clostridium enzyme. quinone 48-55 dehydrogenase/reductase 4 Rattus norvegicus 113-131 8329437-3 1993 Cytochrome b also contains the sites to which various inhibitors and quinone antagonists bind and, consequently, inhibit the oxidoreductase. quinone 69-76 mitochondrially encoded cytochrome b Homo sapiens 0-12 8329437-3 1993 Cytochrome b also contains the sites to which various inhibitors and quinone antagonists bind and, consequently, inhibit the oxidoreductase. quinone 69-76 thioredoxin reductase 1 Homo sapiens 125-139 8329437-7 1993 The comparison of inhibition titrations in combination with the analysis of the primary structures has enabled us to identify amino acid residues in cytochrome b that may be involved in the binding of the inhibitors and, by extrapolation, quinone/quinol. quinone 239-246 mitochondrially encoded cytochrome b Homo sapiens 149-161 1335420-1 1992 Oral pretreatment with E3330, a novel quinone derivative, attenuated liver injury induced with tumor necrosis factor-alpha in galactosamine-sensitized mice. quinone 38-45 tumor necrosis factor Mus musculus 95-122 8384878-1 1993 It has recently been demonstrated that strong illumination under anaerobic conditions leads to the double reduction of the primary quinone acceptor, QA, which in turn promotes the light-induced formation of triplet reaction center chlorophyll, 3P680, a potentially dangerous species to its protein surroundings in the presence of oxygen [Vass, I., Styring, S., Hundal, T., Koivuniemi, A., Aro, E.-M., & Anderson, B. quinone 131-138 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 389-392 8443814-8 1993 High-density growth-arrested wild-type BALB/c 3T3 cells exhibited a greater sensitivity to growth inhibition by the antitumor quinone diaziquone [1,4-cyclohexadiene-1,4- dicarbamic acid, 2,5-bis(1-aziridinyl)-3,6-dioxo-, diethyl ether], which is metabolically activated by DT-diaphorase, than do low-cell-density, growth-arrested cells. quinone 126-133 NAD(P)H dehydrogenase, quinone 1 Mus musculus 273-286 8462726-6 1993 Sulfhydryl compounds (dithiothreitol and glutathione) or quinone-reducing agents (ascorbic acid) prevented the inactivation of ODC; L-ornithine, but not other amino acids, also protected partially ODC. quinone 57-64 ornithine decarboxylase 1 Homo sapiens 127-130 8459834-4 1993 Analysis of the cyt b structure showed that the critical quinone binding sites of the protein are quite divergent from those of other species. quinone 57-64 CYTB Plasmodium falciparum 16-21 8435097-9 1993 In pigmented melanoma cells containing the enzyme tyrosinase, the quinone mediated mechanism of phenolic amine cytotoxicity may be uniquely important and the cellular antioxidant glutathione essential in the detoxification of these quinone-generated intermediates. quinone 66-73 tyrosinase Mus musculus 50-60 8435097-9 1993 In pigmented melanoma cells containing the enzyme tyrosinase, the quinone mediated mechanism of phenolic amine cytotoxicity may be uniquely important and the cellular antioxidant glutathione essential in the detoxification of these quinone-generated intermediates. quinone 232-239 tyrosinase Mus musculus 50-60 1472082-3 1992 NAD(P)H: (quinone acceptor) oxidoreductase (DT-diaphorase) was the major quinone reductase in the tumour accounting for approximately 70% of all the activity measured in microsomes and cytosols (microsomal activity, 28.4 +/- 4.6 nmol/min/mg; cytosolic activity, 94.3 +/- 11.9 nmol/min/mg). quinone 10-17 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 44-57 1292781-1 1992 Substituted phenolic compounds were previously shown to exhibit cytotoxicity towards epithelial cells in the presence of the enzyme tyrosinase as a result of the formation of their quinone products. quinone 181-188 tyrosinase Homo sapiens 132-142 1449531-5 1992 The toxicity experienced by human cell lines after exposure to CB 1954 and NADH was proportional to their levels of the enzyme DT diaphorase NAD(P)H dehydrogenase (quinone), EC 1.6.99.2. quinone 164-171 NAD(P)H quinone dehydrogenase 1 Homo sapiens 127-140 1284192-0 1992 Suppressive effects of E3330, a novel quinone derivative, on tumor necrosis factor-alpha generation from monocytes and macrophages. quinone 38-45 tumor necrosis factor Rattus norvegicus 61-88 1420154-4 1992 Isolated reaction centers showed an approximately 10-nm blue shift in the QY band of P. The standard free energy change between P* and P+BphA- determined from analysis of the long-lived fluorescence from quinone-reduced reaction centers decreased from about -120 meV in the wild-type to about -75 meV in the sym1 mutant. quinone 204-211 noggin Homo sapiens 308-312 1567890-6 1992 Growth factor-responsive NADH oxidase, however, was inhibited greater than 90% by chloroquine and quinone analogues. quinone 98-105 myotrophin Rattus norvegicus 0-13 1528981-3 1992 The pH dependence of the decay of the transient reduced complex, in the presence of an oxidant (oxygen or benzoquinone) indicates the formation of Ru(tap)2(tapH)2+, i.e. the reduced protonated species, subsequent to the electron transfer, with a pKa of 7.6 as confirmed from pulse radiolysis experiments. quinone 106-118 transporter 2, ATP binding cassette subfamily B member Homo sapiens 147-155 1314822-9 1992 Both compound III and ferro-MPO reacted with benzoquinone to regenerate ferric-MPO. quinone 45-57 myeloperoxidase Homo sapiens 28-31 1314822-9 1992 Both compound III and ferro-MPO reacted with benzoquinone to regenerate ferric-MPO. quinone 45-57 myeloperoxidase Homo sapiens 79-82 1314822-12 1992 However, as benzoquinone accumulates, it oxidizes ferro-MPO and compound III to ferric-MPO, thereby increasing the rate of peroxidation. quinone 12-24 myeloperoxidase Homo sapiens 56-59 1314822-12 1992 However, as benzoquinone accumulates, it oxidizes ferro-MPO and compound III to ferric-MPO, thereby increasing the rate of peroxidation. quinone 12-24 myeloperoxidase Homo sapiens 87-90 1314822-13 1992 There is a minimal lag phase under an atmosphere of N2 because ferro-MPO would be rapidly oxidized by benzoquinone, without formation of compound III. quinone 102-114 myeloperoxidase Homo sapiens 69-72 1406605-0 1992 Suggested mechanism for the modulation of the activity of NAD(P)H:quinone acceptor oxidoreductase (DT-diaphorase) by menadione: interpretation of the effect of menadione on 5"-[p-(Fluorosulfonyl)benzoyl]adenosine labeling of rat liver NAD(P)H:quinone acceptor oxidoreductase. quinone 66-73 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 99-112 1406605-0 1992 Suggested mechanism for the modulation of the activity of NAD(P)H:quinone acceptor oxidoreductase (DT-diaphorase) by menadione: interpretation of the effect of menadione on 5"-[p-(Fluorosulfonyl)benzoyl]adenosine labeling of rat liver NAD(P)H:quinone acceptor oxidoreductase. quinone 243-250 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 99-112 1510689-2 1992 In one assay the quinone is maintained in the reduced state by coupling fumarate reduction with the DT-diaphorase reaction, in the other assay by the presence of excess dithionite. quinone 17-24 NAD(P)H quinone dehydrogenase 1 Homo sapiens 100-113 1324674-11 1992 Disproportionation of the GR63178A semi-quinone free radical proceeded with a rate constant of 1 x 10(9) M-1 sec-1 under anaerobic conditions, one order of magnitude faster than doxorubicin. quinone 40-47 secretory blood group 1, pseudogene Homo sapiens 109-114 18601147-1 1992 The process of thermal inactivation of triosephosphate isomerase covalently attached to a silica-based support activated with p-benzoquinone was found to be a complex one. quinone 126-140 triosephosphate isomerase 1 Homo sapiens 39-64 1642648-0 1992 Quinone reduction and redox cycling catalysed by purified rat liver dihydrodiol/3 alpha-hydroxysteroid dehydrogenase. quinone 0-7 aldo-keto reductase family 1, member C14 Rattus norvegicus 80-116 1385952-0 1992 Identification of novel reduced pyridinium derivatives as synthetic co-factors for the enzyme DT diaphorase (NAD(P)H dehydrogenase (quinone), EC 1.6.99.2). quinone 132-139 NAD(P)H quinone dehydrogenase 1 Homo sapiens 94-107 1540627-0 1992 Quinone induced stimulation of hexose monophosphate shunt activity in the guinea pig lens: role of zeta-crystallin. quinone 0-7 quinone oxidoreductase Cavia porcellus 99-114 1311584-0 1992 NAD(P)H (quinone acceptor) oxidoreductase (DT-diaphorase)-mediated two-electron reduction of anthraquinone-based antitumour agents and generation of hydroxyl radicals. quinone 9-16 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 43-56 1543701-2 1992 Since the properties of induced enzyme are very similar to those of NAD(P)H: (quinone-acceptor) oxidoreductase (EC 1.6.99.2), known as DT-diaphorase, from animal cells, structural requirements of quinone derivatives as an inducer of NADH-quinone reductase in E. coli were examined. quinone 78-85 NAD(P)H dehydrogenase, quinone 1 Mus musculus 135-148 1370822-7 1992 Dicumarol, an inhibitor of quinone acceptor oxidoreductase, decreased the production of the hydroxyl radical and attenuated DNA strand breaks in MCF-7 cells treated with MD. quinone 27-34 thioredoxin reductase 1 Homo sapiens 44-58 1540627-8 1992 Hydrogen peroxide, on the other hand, caused decreases in the level of free NADPH alone, serving to confirm our earlier inference that quinone stimulated increases in the guinea pig lens HMS could be mediated through zeta-crystallin NADPH:quinone oxidoreductase activity. quinone 135-142 quinone oxidoreductase Cavia porcellus 217-232 1657937-13 1991 The strong up-field chemical shift for TFQ, and lack of significant chemical shift for 9FQ, suggest that the benzoquinone ring is bound near the paramagnetic cytochrome b heme. quinone 109-121 cytochrome b Bos taurus 158-170 1505078-8 1992 In pigmented melanoma cells containing the enzyme tyrosinase, the quinone-mediated mechanism of inhibition of DNA synthesis via inhibition of thymidylate synthase may be uniquely important in the expression of phenolic amine cytotoxicity. quinone 66-73 tyrosinase Homo sapiens 50-60 1505078-8 1992 In pigmented melanoma cells containing the enzyme tyrosinase, the quinone-mediated mechanism of inhibition of DNA synthesis via inhibition of thymidylate synthase may be uniquely important in the expression of phenolic amine cytotoxicity. quinone 66-73 thymidylate synthetase Homo sapiens 142-162 1516845-2 1992 The results are as follows: in the presence of ubiquinone-3 the extent of peroxidation, as determined by the formation of thiobarbituric acid reactive substances, was only one third of that found in its absence; the quinone can also prevent the fragmentation of apolipoprotein B-100 and the increase of the net negative surface charge of the particle. quinone 50-57 apolipoprotein B Homo sapiens 262-282 1777518-1 1991 The interaction of quinones (menadione and duroquinone) with DT-diaphorase and mitochondrial electron transport chain translocators at low (120 mosM) and high (400 mosM) values of the medium tonicity in the quinone concentration range of 6-90 microM was studied. quinone 19-26 NAD(P)H quinone dehydrogenase 1 Homo sapiens 61-74 1777518-5 1991 At 90 microM K3 50% of quinone is reduced by DT-diaphorase and 50% by the respiratory chain NADH dehydrogenase complex enzymes; about 30% of K3H2 is oxidized via the Q-cycle, about 20%--by the terminal part of the respiratory chain and about 50%--by O2 without cytochrome oxidase. quinone 23-30 NAD(P)H quinone dehydrogenase 1 Homo sapiens 45-58 1874176-1 1991 A water-soluble quinone, coenzyme Q0 (CoQ0), was shown to stimulate insulin release, and dicumarol, an inhibitor of quinone reductase, inhibited glucose-induced insulin release in pancreatic islets. quinone 16-23 insulin Homo sapiens 68-75 1909177-8 1991 Thus, this inhibitor is designed to cross-link the PNPase active site by reductive addition followed by the generation of an alkylating quinone methide species. quinone 136-143 polyribonucleotide nucleotidyltransferase 1 Homo sapiens 51-57 1714284-2 1991 NAD(P)H: (quinone-acceptor) oxidoreductase (quinone reductase, DT-diaphorase, EC 1.6.99.2) is an obligate 2-electron donating enzyme that can reduce a variety of quinones resulting either in bioactivation or bioprotection. quinone 10-17 thioredoxin reductase 1 Homo sapiens 28-42 1714284-2 1991 NAD(P)H: (quinone-acceptor) oxidoreductase (quinone reductase, DT-diaphorase, EC 1.6.99.2) is an obligate 2-electron donating enzyme that can reduce a variety of quinones resulting either in bioactivation or bioprotection. quinone 10-17 NAD(P)H quinone dehydrogenase 1 Homo sapiens 63-76 1906377-1 1991 Non-transformed skin fibroblasts derived from five members of a cancer-prone family and three unrelated healthy volunteers were assayed for their levels of activity of the quinone reductase DT-diaphorase and for their sensitivity to the antitumor quinone mitomycin C (MMC). quinone 172-179 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 190-203 2118386-8 1990 The electron acceptor specificity of this enzyme was very similar to that of NAD(P)H: (quinone acceptor) oxidoreductase (EC 1.6.99.2, DT-diaphorase) from rat liver. quinone 87-94 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 134-147 1654782-1 1991 Hydroquinone, a metabolite of benzene, is converted by human myeloperoxidase to 1,4-benzoquinone, a highly toxic species. quinone 80-96 myeloperoxidase Homo sapiens 61-76 1849003-0 1991 Reduction of the Q-pool by duroquinol via the two quinone-binding sites of the QH2: cytochrome c oxidoreductase. quinone 50-57 LOC104968582 Bos taurus 84-96 1899328-7 1991 In the present study, we have explored kinetic and mechanistic features of the conversion of NAcDEE to NAc delta DEE and found that the reaction requires: (i) oxidation of NAcDEE to the quinone, (ii) the presence of a Lewis base as a catalyst (phosphate anion was the best of those tried in the pH range 6.0-8.0), and (iii) prevention of competing reactions such as Michael additions. quinone 186-193 synuclein alpha Homo sapiens 93-96 1899343-5 1991 Product analysis of HQ oxidation with tyrosinase in the presence of dopa showed the predominant formation in the early stages of hydroxybenzoquinone (HBQ), arising from enzymic hydroxylation and subsequent oxidation of HQ, along with lower amounts of benzoquinone (BQ). quinone 136-148 tyrosinase Homo sapiens 38-48 1899343-5 1991 Product analysis of HQ oxidation with tyrosinase in the presence of dopa showed the predominant formation in the early stages of hydroxybenzoquinone (HBQ), arising from enzymic hydroxylation and subsequent oxidation of HQ, along with lower amounts of benzoquinone (BQ). quinone 151-153 tyrosinase Homo sapiens 38-48 1899380-17 1991 Besides these two commonly used substrates for quinone reductase, the expressed NQO1 protein also effectively metabolized 2,6-dimethylbenzoquinone, methylene blue, p-benzoquinone, 1,4-naphthoquinone, 2-methyl-1,4-benzoquinone, with the latter being the most potent electron acceptor at 50 microM concentration of the substrate. quinone 164-178 NAD(P)H quinone dehydrogenase 1 Homo sapiens 80-84 1817676-2 1991 o-Hydroxylation of the tyrosine residue with tyrosinase in the presence of ascorbic acid, followed by oxidation to the corresponding quinone by potassium ferricyanide at room temperature and condensation with 1,2-diamino-1,2-diphenylethane in the presence of acetonitrile gave a highly fluorescent species. quinone 133-140 tyrosinase Homo sapiens 45-55 1901207-0 1991 The differences in kinetics of rat and human DT diaphorase result in a differential sensitivity of derived cell lines to CB 1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide) DT diaphorase (NAD(P)H dehydrogenase (quinone), EC 1.6.99.2) isolated from Walker 256 rat carcinoma cells can convert CB 1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide) to a cytotoxic DNA interstrand cross-linking agent. quinone 208-215 NAD(P)H quinone dehydrogenase 1 Homo sapiens 45-58 1901207-0 1991 The differences in kinetics of rat and human DT diaphorase result in a differential sensitivity of derived cell lines to CB 1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide) DT diaphorase (NAD(P)H dehydrogenase (quinone), EC 1.6.99.2) isolated from Walker 256 rat carcinoma cells can convert CB 1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide) to a cytotoxic DNA interstrand cross-linking agent. quinone 208-215 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 170-206 1908956-3 1991 The existence of a relatively high superoxide dismutase activity in peripheral nervous tissue, when compared with brain or liver, in combination with the DT-diaphorase activity detected in the sciatic nerve might represent an effective defense mechanism against quinone toxicity, as is also discussed. quinone 262-269 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 154-167 2037233-1 1991 The quinone antibiotic streptonigrin was used to select mutants of Haemophilus influenzae type b defective in human transferrin binding. quinone 4-11 transferrin Homo sapiens 116-127 1718826-6 1991 The antitumor quinone Diaziquone (AZQ) is a poor substrate for DT-diaphorase relative to DCPIP, but effective inhibition of its reduction requires ten-fold higher concentrations of dicoumarol than for inhibition of DCPIP reduction under otherwise similar conditions. quinone 14-21 NAD(P)H quinone dehydrogenase 1 Homo sapiens 63-76 1703398-8 1990 It utilized either NADPH or NADH as electron donor at equal efficiency and displayed high activities in reduction of menadione, 1,4-benzoquinone, and 2,6-dichlorophenolindophenol which are typical substrates for DT-diaphorase. quinone 128-144 NAD(P)H quinone dehydrogenase 1 Homo sapiens 212-225 2246258-10 1990 Kinase activity could be inhibited by halogenated quinone analogues (2,5-dibromo-3-methyl-6-isopropyl-p-benzoquinone and 2,3-diiodo-5-t-butyl-p-benzoquinone) known to inhibit cytochrome b6/f activity. quinone 50-57 petB Spinacia oleracea 175-188 2159331-4 1990 Neither signal is observed in D1-D2-b-559 complexes, indicating that retention of CP47 produces a more native, but quinone-depleted photosystem II reaction center. quinone 115-122 beaded filament structural protein 2 Homo sapiens 82-86 2383630-0 1990 Reactions of excited triplet states of metal substituted myoglobin with dioxygen and quinone. quinone 85-92 myoglobin Homo sapiens 57-66 2162210-3 1990 Labelling studies have shown that the C-2 oxygen in the p-quinone dimer is derived from molecular oxygen. quinone 56-65 complement C2 Homo sapiens 38-41 2162210-5 1990 At pH 7, in the presence of catalase, both the p-quinone dimer and cinnabarinic acid are formed at approximately the same rate and this rate of formation increases with increasing pH. quinone 47-56 catalase Homo sapiens 28-36 2343185-2 1990 In this study we have investigated the activity of quinone reductase (QR) (NADPH:DT diaphorase), a quinone detoxifying enzyme, in whole bone marrow and bone marrow-derived stromal cells from these two strains of mice. quinone 51-58 crystallin, zeta Mus musculus 70-72 2343185-7 1990 Thus, differences in target organ QR activity may contribute to differential susceptibility to quinone-generating bone marrow toxins. quinone 95-102 crystallin, zeta Mus musculus 34-36 2343185-2 1990 In this study we have investigated the activity of quinone reductase (QR) (NADPH:DT diaphorase), a quinone detoxifying enzyme, in whole bone marrow and bone marrow-derived stromal cells from these two strains of mice. quinone 51-58 NAD(P)H dehydrogenase, quinone 1 Mus musculus 81-94 2307236-0 1990 Stimulation of nerve growth factor synthesis/secretion by 1,4-benzoquinone and its derivatives in cultured mouse astroglial cells. quinone 58-74 nerve growth factor Mus musculus 15-34 2154673-13 1990 The activity of DT-diaphorase, a quinone reductase that has been invoked as a protective mechanism in quinone-induced toxicity, was 4-fold higher in LTF cells than macrophages. quinone 33-40 NAD(P)H quinone dehydrogenase 1 Homo sapiens 16-29 2154673-13 1990 The activity of DT-diaphorase, a quinone reductase that has been invoked as a protective mechanism in quinone-induced toxicity, was 4-fold higher in LTF cells than macrophages. quinone 33-40 lactotransferrin Homo sapiens 149-152 2110108-8 1990 In the latter capacity, reduced cytochrome P450 can be replaced by EDTA--Fe2+ or by the superoxide radical as generated through redox cycling of a quinone such as menadione. quinone 147-154 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 32-47 1692249-9 1990 Dicoumarol, an inhibitor of DT-diaphorase, increased the cytotoxic activity of both benzoquinone mustard and benzoquinone dimustard in L5178Y/HBM10 cells. quinone 84-96 NAD(P)H dehydrogenase, quinone 1 Mus musculus 28-41 1692249-9 1990 Dicoumarol, an inhibitor of DT-diaphorase, increased the cytotoxic activity of both benzoquinone mustard and benzoquinone dimustard in L5178Y/HBM10 cells. quinone 109-121 NAD(P)H dehydrogenase, quinone 1 Mus musculus 28-41 1692249-10 1990 This study provides evidence that elevated DT-diaphorase activity in the resistant cells contributes to resistance to benzoquinone mustard and benzoquinone dimustard, possibly by decreasing the formation of the semiquinone intermediates of these agents. quinone 118-130 NAD(P)H dehydrogenase, quinone 1 Mus musculus 43-56 1692249-10 1990 This study provides evidence that elevated DT-diaphorase activity in the resistant cells contributes to resistance to benzoquinone mustard and benzoquinone dimustard, possibly by decreasing the formation of the semiquinone intermediates of these agents. quinone 143-155 NAD(P)H dehydrogenase, quinone 1 Mus musculus 43-56 2154673-11 1990 High performance liquid chromatographic analysis of incubations containing purified myeloperoxidase, hydroquinone, and hydrogen peroxide showed that greater than 90% of hydroquinone was removed and could be detected stoichometrically as 1,4-benzoquinone. quinone 237-253 myeloperoxidase Homo sapiens 84-99 2294024-1 1990 Adrenodoxin stimulated the oxidation of NADPH by 1,4-benzoquinone, catalyzed by NADPH:adrenodoxin reductase. quinone 49-65 ferredoxin reductase Homo sapiens 86-107 2307236-4 1990 In addition, the results of experiments with 1,2-benzoquinone derivatives indicated that the presence of a long aliphatic side chain in the molecule eliminates the stimulatory effect of 1,4-benzoquinone on NGF synthesis in astroglial cells. quinone 186-202 nerve growth factor Mus musculus 206-209 1965196-5 1990 It is our belief that the structure of the quinone cofactor, and the Cu(II) site in MAOx are identical to these sites in PAO and DAO. quinone 43-50 amine oxidase copper containing 1 Homo sapiens 129-132 33811108-4 2020 Further investigations demonstrated that a quinone metabolite of MOA could be trapped by GSH in a HLM incubation system, while CYPs2D6, 1A2 and 2E1 were the major contributors to catalyze the metabolic activation of MOA to the corresponding O-qunione intermediate. quinone 43-50 oxysterol binding protein 2 Homo sapiens 98-101 33811108-8 2020 Further investigations demonstrated that a quinone metabolite of MOA could be trapped by GSH in a HLM incubation system, while CYPs2D6, 1A2 and 2E1 were the major contributors to catalyze the metabolic activation of MOA to the corresponding O-qunione intermediate. quinone 43-50 oxysterol binding protein 2 Homo sapiens 98-101 34971743-7 2022 Upon exploring the underlying mechanism by which lincRNA-p21 mediates benzene-induced hematotoxicity, we observed that the negative regulation of 1,4-benzoquinone (1,4-BQ) on cell cycle arrest and inhibition of K562 cell proliferation was partially relieved by lincRNA-p21 knockdown, which can inhibit the expression of P21 and thereby suppress the toxic effects of 1,4-BQ. quinone 146-162 tumor protein p53 pathway corepressor 1 Homo sapiens 49-60 2336718-2 1990 It is established that the incubation of cells in the presence of lipophilic quinone OBQ-1 results in the formation of the intracellular methemoglobin in erythrocytes and the intensification of the ferricyanide reduction by HeLa cells. quinone 77-84 hemoglobin subunit gamma 2 Homo sapiens 137-150 33800410-5 2021 We report that the CCNF that was produced by an oxygen-rich coal fragment from C6mimCl ionic liquid extraction showed the highest concentrations of quinone and ester groups on the surface. quinone 148-155 cyclin F Homo sapiens 19-23 34971743-7 2022 Upon exploring the underlying mechanism by which lincRNA-p21 mediates benzene-induced hematotoxicity, we observed that the negative regulation of 1,4-benzoquinone (1,4-BQ) on cell cycle arrest and inhibition of K562 cell proliferation was partially relieved by lincRNA-p21 knockdown, which can inhibit the expression of P21 and thereby suppress the toxic effects of 1,4-BQ. quinone 146-162 tumor protein p53 pathway corepressor 1 Homo sapiens 261-272 34971743-7 2022 Upon exploring the underlying mechanism by which lincRNA-p21 mediates benzene-induced hematotoxicity, we observed that the negative regulation of 1,4-benzoquinone (1,4-BQ) on cell cycle arrest and inhibition of K562 cell proliferation was partially relieved by lincRNA-p21 knockdown, which can inhibit the expression of P21 and thereby suppress the toxic effects of 1,4-BQ. quinone 146-162 H3 histone pseudogene 16 Homo sapiens 320-323 34971743-7 2022 Upon exploring the underlying mechanism by which lincRNA-p21 mediates benzene-induced hematotoxicity, we observed that the negative regulation of 1,4-benzoquinone (1,4-BQ) on cell cycle arrest and inhibition of K562 cell proliferation was partially relieved by lincRNA-p21 knockdown, which can inhibit the expression of P21 and thereby suppress the toxic effects of 1,4-BQ. quinone 164-170 tumor protein p53 pathway corepressor 1 Homo sapiens 49-60 34971743-7 2022 Upon exploring the underlying mechanism by which lincRNA-p21 mediates benzene-induced hematotoxicity, we observed that the negative regulation of 1,4-benzoquinone (1,4-BQ) on cell cycle arrest and inhibition of K562 cell proliferation was partially relieved by lincRNA-p21 knockdown, which can inhibit the expression of P21 and thereby suppress the toxic effects of 1,4-BQ. quinone 164-170 tumor protein p53 pathway corepressor 1 Homo sapiens 261-272 34971743-7 2022 Upon exploring the underlying mechanism by which lincRNA-p21 mediates benzene-induced hematotoxicity, we observed that the negative regulation of 1,4-benzoquinone (1,4-BQ) on cell cycle arrest and inhibition of K562 cell proliferation was partially relieved by lincRNA-p21 knockdown, which can inhibit the expression of P21 and thereby suppress the toxic effects of 1,4-BQ. quinone 164-170 H3 histone pseudogene 16 Homo sapiens 320-323 34971743-7 2022 Upon exploring the underlying mechanism by which lincRNA-p21 mediates benzene-induced hematotoxicity, we observed that the negative regulation of 1,4-benzoquinone (1,4-BQ) on cell cycle arrest and inhibition of K562 cell proliferation was partially relieved by lincRNA-p21 knockdown, which can inhibit the expression of P21 and thereby suppress the toxic effects of 1,4-BQ. quinone 366-372 tumor protein p53 pathway corepressor 1 Homo sapiens 49-60 34971743-7 2022 Upon exploring the underlying mechanism by which lincRNA-p21 mediates benzene-induced hematotoxicity, we observed that the negative regulation of 1,4-benzoquinone (1,4-BQ) on cell cycle arrest and inhibition of K562 cell proliferation was partially relieved by lincRNA-p21 knockdown, which can inhibit the expression of P21 and thereby suppress the toxic effects of 1,4-BQ. quinone 366-372 tumor protein p53 pathway corepressor 1 Homo sapiens 261-272 34971743-7 2022 Upon exploring the underlying mechanism by which lincRNA-p21 mediates benzene-induced hematotoxicity, we observed that the negative regulation of 1,4-benzoquinone (1,4-BQ) on cell cycle arrest and inhibition of K562 cell proliferation was partially relieved by lincRNA-p21 knockdown, which can inhibit the expression of P21 and thereby suppress the toxic effects of 1,4-BQ. quinone 366-372 H3 histone pseudogene 16 Homo sapiens 320-323 34929209-7 2022 Mechanistically, acetylated proteomics revealed that 1,4-benzoquinone (1,4-BQ) induced acetylation of PKM2 at position K66, and this modification contributed to the increase of PKM2 expression and can be inhibited by inhibition of acetyltransferase GCN5. quinone 53-69 pyruvate kinase M1/2 Homo sapiens 102-106 34929209-7 2022 Mechanistically, acetylated proteomics revealed that 1,4-benzoquinone (1,4-BQ) induced acetylation of PKM2 at position K66, and this modification contributed to the increase of PKM2 expression and can be inhibited by inhibition of acetyltransferase GCN5. quinone 53-69 pyruvate kinase M1/2 Homo sapiens 177-181 34929209-7 2022 Mechanistically, acetylated proteomics revealed that 1,4-benzoquinone (1,4-BQ) induced acetylation of PKM2 at position K66, and this modification contributed to the increase of PKM2 expression and can be inhibited by inhibition of acetyltransferase GCN5. quinone 53-69 lysine acetyltransferase 2A Homo sapiens 249-253 34929209-7 2022 Mechanistically, acetylated proteomics revealed that 1,4-benzoquinone (1,4-BQ) induced acetylation of PKM2 at position K66, and this modification contributed to the increase of PKM2 expression and can be inhibited by inhibition of acetyltransferase GCN5. quinone 71-77 pyruvate kinase M1/2 Homo sapiens 102-106 34929209-7 2022 Mechanistically, acetylated proteomics revealed that 1,4-benzoquinone (1,4-BQ) induced acetylation of PKM2 at position K66, and this modification contributed to the increase of PKM2 expression and can be inhibited by inhibition of acetyltransferase GCN5. quinone 71-77 pyruvate kinase M1/2 Homo sapiens 177-181 34929209-7 2022 Mechanistically, acetylated proteomics revealed that 1,4-benzoquinone (1,4-BQ) induced acetylation of PKM2 at position K66, and this modification contributed to the increase of PKM2 expression and can be inhibited by inhibition of acetyltransferase GCN5. quinone 71-77 lysine acetyltransferase 2A Homo sapiens 249-253 34748909-6 2021 Importantly, the anti-oxytotic/ferroptotic character of the quinone compounds relied on their capacity to target and directly prevent lipid peroxidation in a manner that required the reducing activity of cellular redox enzymes, such as NAD(P)H:quinone oxidoreductase 1 (NQO1) and ferroptosis suppressor protein 1 (FSP1). quinone 60-67 NAD(P)H quinone dehydrogenase 1 Homo sapiens 270-274 34894599-2 2022 The grafting procedure was optimized so that the pH-dependent electrochemical response of the grafted quinone did not overlay with that of the electroactive biofilm. quinone 102-109 phenylalanine hydroxylase Homo sapiens 49-51 34894599-3 2022 The variation of the formal potential of the grafted quinone as a function of pH was linear over the pH range 1-10 with a slope of - 64 mV. quinone 53-60 phenylalanine hydroxylase Homo sapiens 78-80 34894599-3 2022 The variation of the formal potential of the grafted quinone as a function of pH was linear over the pH range 1-10 with a slope of - 64 mV. quinone 53-60 phenylalanine hydroxylase Homo sapiens 101-103 34884863-1 2021 The ability of NQO2 to increase the production of free radicals under enhanced generation of quinone derivatives of catecholamines is considered to be a component of neurodegenerative disease pathogenesis. quinone 93-100 N-ribosyldihydronicotinamide quinone reductase 2 Mus musculus 15-19 34927421-0 2022 Carcinogenic Risk of 2,6-Di-tert-Butylphenol and Its Quinone Metabolite 2,6-DTBQ Through Their Interruption of RARbeta: In Vivo, In Vitro, and In Silico Investigations. quinone 53-60 retinoic acid receptor alpha Homo sapiens 111-118 34813075-3 2022 The narrow entrance of the quinone chamber located in ND1 subunit forms a bottleneck (eye of a needle) which in all resolved structures was shown to be too small for a bulky quinone to pass through, and it was suggested that a conformational change is required to open the channel. quinone 27-34 mitochondrially encoded NADH dehydrogenase 1 Homo sapiens 54-57 34813075-3 2022 The narrow entrance of the quinone chamber located in ND1 subunit forms a bottleneck (eye of a needle) which in all resolved structures was shown to be too small for a bulky quinone to pass through, and it was suggested that a conformational change is required to open the channel. quinone 174-181 mitochondrially encoded NADH dehydrogenase 1 Homo sapiens 54-57 34748909-6 2021 Importantly, the anti-oxytotic/ferroptotic character of the quinone compounds relied on their capacity to target and directly prevent lipid peroxidation in a manner that required the reducing activity of cellular redox enzymes, such as NAD(P)H:quinone oxidoreductase 1 (NQO1) and ferroptosis suppressor protein 1 (FSP1). quinone 60-67 NAD(P)H quinone dehydrogenase 1 Homo sapiens 236-268 34852219-2 2022 Instead of affecting the quinone-binding site targeted by most CI inhibitors, SMIP004-7 and its cytochrome P450-dependent activated metabolite(s) have an uncompetitive mechanism of inhibition involving a distinct N-terminal region of catalytic subunit NDUFS2 that leads to rapid disassembly of CI. quinone 25-32 NADH:ubiquinone oxidoreductase core subunit S2 Homo sapiens 252-258 34757293-6 2021 Then, the feasibility of tyrosinase-treated congener annexin A5 with easily reactive quinone functional moiety was conjugated with fluorescent tag dibenzocyclooctyne-PEG4-TAMRA for labeling of apoptotic cells. quinone 85-92 tyrosinase Homo sapiens 25-35 34757293-6 2021 Then, the feasibility of tyrosinase-treated congener annexin A5 with easily reactive quinone functional moiety was conjugated with fluorescent tag dibenzocyclooctyne-PEG4-TAMRA for labeling of apoptotic cells. quinone 85-92 annexin A5 Homo sapiens 53-63 34748909-6 2021 Importantly, the anti-oxytotic/ferroptotic character of the quinone compounds relied on their capacity to target and directly prevent lipid peroxidation in a manner that required the reducing activity of cellular redox enzymes, such as NAD(P)H:quinone oxidoreductase 1 (NQO1) and ferroptosis suppressor protein 1 (FSP1). quinone 60-67 atlastin GTPase 1 Homo sapiens 280-312 34748909-6 2021 Importantly, the anti-oxytotic/ferroptotic character of the quinone compounds relied on their capacity to target and directly prevent lipid peroxidation in a manner that required the reducing activity of cellular redox enzymes, such as NAD(P)H:quinone oxidoreductase 1 (NQO1) and ferroptosis suppressor protein 1 (FSP1). quinone 60-67 atlastin GTPase 1 Homo sapiens 314-318 34859125-2 2021 These proteins possess NAD(P)H:quinone oxidoreductase activity and convert quinones to hydroquinones through two-electron reduction, using NAD(P)H and quinone as electron donor and acceptor, respectively. quinone 151-158 crystallin zeta Homo sapiens 31-53 34303080-4 2021 In this study, based on the analysis of NQO1 catalytic pocket, the naphthoquinone trigger group 13 rationally designed by expanding the aromatic plane of the benzoquinone trigger group 10 shows significantly increased sensitivity to NQO1. quinone 158-170 NAD(P)H quinone dehydrogenase 1 Homo sapiens 40-44 34303080-4 2021 In this study, based on the analysis of NQO1 catalytic pocket, the naphthoquinone trigger group 13 rationally designed by expanding the aromatic plane of the benzoquinone trigger group 10 shows significantly increased sensitivity to NQO1. quinone 158-170 NAD(P)H quinone dehydrogenase 1 Homo sapiens 233-237 34329742-1 2021 beta-Lapachone is a classic quinone-containing antitumor NQO1-bioactivatable drug that directly kills NQO1-overexpressing cancer cells. quinone 28-35 NAD(P)H quinone dehydrogenase 1 Homo sapiens 57-61 34681535-7 2021 AA only slows mechanism-based inactivation of PPO induced by catechol, possibly owing to the prevention of quinone formation. quinone 107-114 catechol oxidase B, chloroplastic Solanum tuberosum 46-49 34329742-1 2021 beta-Lapachone is a classic quinone-containing antitumor NQO1-bioactivatable drug that directly kills NQO1-overexpressing cancer cells. quinone 28-35 NAD(P)H quinone dehydrogenase 1 Homo sapiens 102-106 34282315-0 2021 Structure-activity relationships of natural quinone vegfrecine analogs with potent activity against VEGFR-1 and -2 tyrosine kinases. quinone 44-51 kinase insert domain receptor Homo sapiens 100-114 34418406-6 2021 Notably, the expression of glycine N-methyltransferase (GNMT), an enzyme catalyzing the transformation of glycine to sarcosine, was upregulated both in 1,4-BQ treated AHH-1 cells and benzene-exposed workers. quinone 152-158 glycine N-methyltransferase Homo sapiens 27-54 34418406-6 2021 Notably, the expression of glycine N-methyltransferase (GNMT), an enzyme catalyzing the transformation of glycine to sarcosine, was upregulated both in 1,4-BQ treated AHH-1 cells and benzene-exposed workers. quinone 152-158 glycine N-methyltransferase Homo sapiens 56-60 34228969-1 2021 NAD(P)H: Quinone Oxidoreductase 1 (NQO1) is an antioxidant enzyme that catalyzes the two-electron reduction of several different classes of quinone-like compounds (quinones, quinone imines, nitroaromatics, and azo dyes). quinone 140-147 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-33 34382787-3 2021 Early publications utilizing tyrosinase fromAgaricus bisporus(abTYR) showed the potential to convert tyrosine residues into ortho-quinone functional groups, but this enzyme is challenging to produce recombinantly and suffers from some limitations in substrate scope. quinone 130-137 tyrosinase Homo sapiens 29-39 34266924-0 2021 The benzene hematotoxic and reactive metabolite 1,4-benzoquinone impairs the activity of the histone methyltransferase SETD2 and causes aberrant H3K36 trimethylation (H3K36me3). quinone 48-64 PR/SET domain 9 Homo sapiens 93-118 34266924-0 2021 The benzene hematotoxic and reactive metabolite 1,4-benzoquinone impairs the activity of the histone methyltransferase SETD2 and causes aberrant H3K36 trimethylation (H3K36me3). quinone 48-64 SET domain containing 2, histone lysine methyltransferase Homo sapiens 119-124 34266924-8 2021 Herein, we show that BQ, the major leukemogenic metabolite of BZ, inhibits irreversibly the human histone methyltransferase SETD2 resulting in decreased H3K36 trimethylation (H3K36me3). quinone 21-23 PR/SET domain 9 Homo sapiens 98-123 34266924-8 2021 Herein, we show that BQ, the major leukemogenic metabolite of BZ, inhibits irreversibly the human histone methyltransferase SETD2 resulting in decreased H3K36 trimethylation (H3K36me3). quinone 21-23 SET domain containing 2, histone lysine methyltransferase Homo sapiens 124-129 34266924-9 2021 Our mechanistic studies further indicate that the BQ-dependent inactivation of SETD2 is due to covalent binding of BQ to reactive Zn-finger cysteines within the catalytic domain of the enzyme. quinone 115-117 SET domain containing 2, histone lysine methyltransferase Homo sapiens 79-84 34266924-11 2021 Experiments conducted in hematopoietic cells confirm that exposure to BQ results in the formation of SETD2 cross-links/oligomers and concomitant loss of H3K36me3 in cells. quinone 70-72 SET domain containing 2, histone lysine methyltransferase Homo sapiens 101-106 34266924-12 2021 Taken together, our data indicate that BQ, a major hematotoxic metabolite of BZ could contribute to BZ-dependent leukemogenesis by perturbing the functions of SETD2, an histone lysine methyltransferase of hematopoietic relevance. quinone 39-41 SET domain containing 2, histone lysine methyltransferase Homo sapiens 159-164 34266924-15 2021 We found that benzoquinone irreversibly impairs SETD2, a histone H3K36 methyltransferase that plays a key role in hematopoiesis. quinone 14-26 SET domain containing 2, histone lysine methyltransferase Homo sapiens 48-53 34632188-3 2021 In this study, a group of quinone-derived compounds were examined for their potential inhibitory effect against human IRAK1 and IRAK4 kinases in vitro. quinone 26-33 interleukin 1 receptor associated kinase 1 Homo sapiens 118-123 34632188-3 2021 In this study, a group of quinone-derived compounds were examined for their potential inhibitory effect against human IRAK1 and IRAK4 kinases in vitro. quinone 26-33 interleukin 1 receptor associated kinase 4 Homo sapiens 128-133 34228969-1 2021 NAD(P)H: Quinone Oxidoreductase 1 (NQO1) is an antioxidant enzyme that catalyzes the two-electron reduction of several different classes of quinone-like compounds (quinones, quinone imines, nitroaromatics, and azo dyes). quinone 140-147 NAD(P)H quinone dehydrogenase 1 Homo sapiens 35-39 34228969-8 2021 Therefore, this article summarizes the interactions of NQO1 and NQO2 with different pharmacological agents, endogenous biochemicals, and environmental contaminants that would be useful in the development of therapeutic approaches to reduce the adverse drug reactions as well as protection against quinone-induced oxidative damage. quinone 297-304 NAD(P)H quinone dehydrogenase 1 Homo sapiens 55-59 34228969-8 2021 Therefore, this article summarizes the interactions of NQO1 and NQO2 with different pharmacological agents, endogenous biochemicals, and environmental contaminants that would be useful in the development of therapeutic approaches to reduce the adverse drug reactions as well as protection against quinone-induced oxidative damage. quinone 297-304 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 64-68 34068281-3 2021 NQO2 is highly expressed in the liver, where it participates in quinone metabolism, but recent evidence indicates that it may also play a role in the regulation of oxidative stress and autophagy. quinone 64-71 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 0-4 34356648-2 2021 Based on the findings of clinical trials, it is safe to conclude that genetic predisposition and environmental factors are the main factors responsible for the formation of colorectal cancer.The NQO1 gene plays an important role in reducing endogenous and exogenous quinones as well as quinone compounds to hydroquinones. quinone 286-293 NAD(P)H quinone dehydrogenase 1 Homo sapiens 195-199 34276623-6 2021 These multiheme c-Cyts may form the pathways similar to those found in bacteria for transferring electrons from the quinone/quinol pool in the cytoplasmic membrane to the Fe(III) (oxyhydr)oxides external to the archaeal cells. quinone 116-123 general transcription factor IIE subunit 1 Homo sapiens 171-178 34135385-7 2021 D199MT-ND1 is part of a cluster of charged amino acid residues that are suggested to be important for efficient coupling of quinone reduction and proton translocation. quinone 124-131 mitochondrially encoded NADH dehydrogenase 1 Homo sapiens 4-10 34130454-3 2021 We show that lytic polysaccharide monooxygenases (LPMOs), through LPMO-catalyzed oxidation of hydroquinone, can efficiently cooperate with glucose dehydrogenase (GDH) to achieve quinone redox cycling. quinone 178-185 hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase Homo sapiens 139-160 34130454-3 2021 We show that lytic polysaccharide monooxygenases (LPMOs), through LPMO-catalyzed oxidation of hydroquinone, can efficiently cooperate with glucose dehydrogenase (GDH) to achieve quinone redox cycling. quinone 178-185 hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase Homo sapiens 162-165 34203690-2 2021 As a test, we coupled deep neural models for quinone formation, metabolite structures, and biomolecule reactivity to predict bioactivation pathways for 32 BET inhibitors and validate the bioactivation of select inhibitors experimentally. quinone 45-52 delta/notch like EGF repeat containing Homo sapiens 155-158 34203690-10 2021 Nevertheless, our coupled modeling approach predicted BET inhibitor bioactivations including novel extended quinone methides, and we experimentally verified those pathways highlighting potential concerns for toxicity in the development of these new drug leads. quinone 108-115 delta/notch like EGF repeat containing Homo sapiens 54-57 34821330-10 2021 It is supposed that the synergistic interactions of the adhesive catechol group, displacement of water on the wet skin surface by the positively charged -NH3+ groups of CS and the water-repelling potential of the hydrophobic unit of the catechol derivative, the protection of the catechol group from oxidation into a less adhesive quinone group, and the energy dissipation capacity of the mechanically tough hydrogel contribute to the strong and repeatable wet tissue adhesion. quinone 331-338 citrate synthase Homo sapiens 169-171 34348209-2 2021 The benzoquinone structural motive is associated with mutagenicity and carcinogenicity, and also with induction of the oxidative stress response through the Nrf2 pathway. quinone 4-16 NFE2 like bZIP transcription factor 2 Homo sapiens 157-161 34443722-7 2021 Two protons and two electrons are involved in this reaction, which is shown to be sensitive to the concentration of glucose, restraining its origin to the electron transfer from FAD in the active site of GOx to the electrode via direct or mediated by quinone derivatives acting as mediators. quinone 251-258 hydroxyacid oxidase 1 Homo sapiens 204-207 34067848-1 2021 Lipids play a pivotal role in cellular respiration, providing the natural environment in which an oxidoreductase interacts with the quinone pool. quinone 132-139 hydroxysteroid 17-beta dehydrogenase 6 Homo sapiens 98-112 35533403-5 2022 Then, further transformation could not be induced from the addition of HO2- and CH3OO- to p-BQ. quinone 90-94 heme oxygenase 2 Homo sapiens 71-74 35499189-3 2022 To this end, the nanohybrids of sub-1 nm MoC quantum dots decorating nitrogen-doped ultrathin graphene (MoC QDs/NG) are developed as the advanced cathode electrocatalysts toward redox conversion between quinone and hydroquinone (H2 Q/Q). quinone 203-210 SUB1 regulator of transcription Homo sapiens 32-37 35507758-1 2022 Amine oxidase copper containing 3 (AOC3), also known as plasma amine oxidase, semicarbazide-sensitive amine oxidase, or vascular adhesion protein-1, catalyzes the oxidative deamination of primary amines to aldehydes using copper and a quinone as cofactors. quinone 235-242 amine oxidase copper containing 3 Homo sapiens 0-33 35507758-1 2022 Amine oxidase copper containing 3 (AOC3), also known as plasma amine oxidase, semicarbazide-sensitive amine oxidase, or vascular adhesion protein-1, catalyzes the oxidative deamination of primary amines to aldehydes using copper and a quinone as cofactors. quinone 235-242 amine oxidase copper containing 3 Homo sapiens 35-39 35507758-1 2022 Amine oxidase copper containing 3 (AOC3), also known as plasma amine oxidase, semicarbazide-sensitive amine oxidase, or vascular adhesion protein-1, catalyzes the oxidative deamination of primary amines to aldehydes using copper and a quinone as cofactors. quinone 235-242 amine oxidase copper containing 3 Homo sapiens 78-115 35597283-0 2022 SifR is an Rrf2-family quinone sensor associated with catechol iron uptake in Streptococcus pneumoniae D39. quinone 23-30 GTP dependent ribosome recycling factor mitochondrial 2 Homo sapiens 11-15 35533403-4 2022 For p-BQ, the nucleophilic attack of HO2-, CH3OO-, PMS, and PAA might prefer to occur on the carbonyl carbons, which have more positive atomic charges. quinone 4-8 heme oxygenase 2 Homo sapiens 37-40 35090502-2 2022 NAD(P)H: quinone oxidoreductase 1 (NQO1) protects cells from oxidative stress and toxic quinone damage. quinone 88-95 NAD(P)H dehydrogenase, quinone 1 Mus musculus 0-33 35332614-2 2022 In contrast to catechol derivatives, which are generally susceptible to oxidation by air under ambient conditions, the monophenol-based TBAD remains stable under alkaline and neutral conditions, and is activated to oxidized quinone in situ by tyrosinase to initiate melanin-like polymerization. quinone 224-231 tyrosinase Homo sapiens 243-253 35384739-0 2022 A Nanocurcumin and Pyrroloquinoline Quinone Formulation Prevents Hypobaric Hypoxia-Induced Skeletal Muscle Atrophy by Modulating NF-kappaB Signaling Pathway. quinone 36-43 nuclear factor kappa B subunit 1 Homo sapiens 129-138 35384739-2 2022 A nanocurcumin and pyrroloquinoline quinone formulation prevents hypobaric hypoxia-induced skeletal muscle atrophy by modulating NF-kappaB signaling pathway. quinone 36-43 nuclear factor kappa B subunit 1 Homo sapiens 129-138 35383983-0 2022 Blocking exosomal secretion aggravates 1,4-Benzoquinone-induced mitochondrial fission activated by the AMPK/MFF/Drp1 pathway in HL-60 cells. quinone 39-55 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 103-107 35383983-0 2022 Blocking exosomal secretion aggravates 1,4-Benzoquinone-induced mitochondrial fission activated by the AMPK/MFF/Drp1 pathway in HL-60 cells. quinone 39-55 mitochondrial fission factor Homo sapiens 108-111 35383983-0 2022 Blocking exosomal secretion aggravates 1,4-Benzoquinone-induced mitochondrial fission activated by the AMPK/MFF/Drp1 pathway in HL-60 cells. quinone 39-55 dynamin 1 like Homo sapiens 112-116 35383983-3 2022 In this study, exposure of human promyelocytic leukemia cells (HL-60) to 1,4-benzoquinone (1,4-BQ; an active metabolite of benzene) increased the intracellular reactive oxygen species levels, decreased the mitochondrial membrane potential, adenosine triphosphate production and mitochondrial DNA (mtDNA) copy number, up-regulated the expression of mitochondrial fission proteins Drp1 and Fis1, and down-regulated the expression of mitochondrial fusion proteins Mfn2 and Opa1. quinone 73-89 dynamin 1 like Homo sapiens 379-383 35383983-3 2022 In this study, exposure of human promyelocytic leukemia cells (HL-60) to 1,4-benzoquinone (1,4-BQ; an active metabolite of benzene) increased the intracellular reactive oxygen species levels, decreased the mitochondrial membrane potential, adenosine triphosphate production and mitochondrial DNA (mtDNA) copy number, up-regulated the expression of mitochondrial fission proteins Drp1 and Fis1, and down-regulated the expression of mitochondrial fusion proteins Mfn2 and Opa1. quinone 73-89 fission, mitochondrial 1 Homo sapiens 388-392 35383983-3 2022 In this study, exposure of human promyelocytic leukemia cells (HL-60) to 1,4-benzoquinone (1,4-BQ; an active metabolite of benzene) increased the intracellular reactive oxygen species levels, decreased the mitochondrial membrane potential, adenosine triphosphate production and mitochondrial DNA (mtDNA) copy number, up-regulated the expression of mitochondrial fission proteins Drp1 and Fis1, and down-regulated the expression of mitochondrial fusion proteins Mfn2 and Opa1. quinone 73-89 mitofusin 2 Homo sapiens 461-465 35383983-3 2022 In this study, exposure of human promyelocytic leukemia cells (HL-60) to 1,4-benzoquinone (1,4-BQ; an active metabolite of benzene) increased the intracellular reactive oxygen species levels, decreased the mitochondrial membrane potential, adenosine triphosphate production and mitochondrial DNA (mtDNA) copy number, up-regulated the expression of mitochondrial fission proteins Drp1 and Fis1, and down-regulated the expression of mitochondrial fusion proteins Mfn2 and Opa1. quinone 73-89 OPA1 mitochondrial dynamin like GTPase Homo sapiens 470-474 35383983-3 2022 In this study, exposure of human promyelocytic leukemia cells (HL-60) to 1,4-benzoquinone (1,4-BQ; an active metabolite of benzene) increased the intracellular reactive oxygen species levels, decreased the mitochondrial membrane potential, adenosine triphosphate production and mitochondrial DNA (mtDNA) copy number, up-regulated the expression of mitochondrial fission proteins Drp1 and Fis1, and down-regulated the expression of mitochondrial fusion proteins Mfn2 and Opa1. quinone 91-97 dynamin 1 like Homo sapiens 379-383 35383983-3 2022 In this study, exposure of human promyelocytic leukemia cells (HL-60) to 1,4-benzoquinone (1,4-BQ; an active metabolite of benzene) increased the intracellular reactive oxygen species levels, decreased the mitochondrial membrane potential, adenosine triphosphate production and mitochondrial DNA (mtDNA) copy number, up-regulated the expression of mitochondrial fission proteins Drp1 and Fis1, and down-regulated the expression of mitochondrial fusion proteins Mfn2 and Opa1. quinone 91-97 fission, mitochondrial 1 Homo sapiens 388-392 35383983-3 2022 In this study, exposure of human promyelocytic leukemia cells (HL-60) to 1,4-benzoquinone (1,4-BQ; an active metabolite of benzene) increased the intracellular reactive oxygen species levels, decreased the mitochondrial membrane potential, adenosine triphosphate production and mitochondrial DNA (mtDNA) copy number, up-regulated the expression of mitochondrial fission proteins Drp1 and Fis1, and down-regulated the expression of mitochondrial fusion proteins Mfn2 and Opa1. quinone 91-97 mitofusin 2 Homo sapiens 461-465 35383983-3 2022 In this study, exposure of human promyelocytic leukemia cells (HL-60) to 1,4-benzoquinone (1,4-BQ; an active metabolite of benzene) increased the intracellular reactive oxygen species levels, decreased the mitochondrial membrane potential, adenosine triphosphate production and mitochondrial DNA (mtDNA) copy number, up-regulated the expression of mitochondrial fission proteins Drp1 and Fis1, and down-regulated the expression of mitochondrial fusion proteins Mfn2 and Opa1. quinone 91-97 OPA1 mitochondrial dynamin like GTPase Homo sapiens 470-474 35214125-0 2022 Identification of a Quinone Derivative as a YAP/TEAD Activity Modulator from a Repurposing Library. quinone 20-27 Yes1 associated transcriptional regulator Homo sapiens 44-47 35363885-4 2022 Here, we combined atomistic docking, molecular dynamics simulations and site-directed mutagenesis on respiratory complex I from Yarrowia lipolytica to identify a quinone (Q) binding site on its surface near the horizontal amphipathic helices of ND1 and NDUFS7 subunits. quinone 162-169 nd1 Yarrowia lipolytica 245-248 35363885-4 2022 Here, we combined atomistic docking, molecular dynamics simulations and site-directed mutagenesis on respiratory complex I from Yarrowia lipolytica to identify a quinone (Q) binding site on its surface near the horizontal amphipathic helices of ND1 and NDUFS7 subunits. quinone 171-172 nd1 Yarrowia lipolytica 245-248 35347544-5 2022 The quinone derivative compounds like mitomycin C, RH1, E09 (Apaziquone) and beta-lapachone causes cell death by NQO1 reduction of two electrons. quinone 4-11 NAD(P)H quinone dehydrogenase 1 Homo sapiens 113-117 35347544-8 2022 The NQO1 exhibit suppression of chemical-mediated carcinogenesis by various properties of NQO1 which includes, detoxification of quinone scavenger of superoxide anion radical, antioxidant enzyme, protein stabilizer. quinone 129-136 NAD(P)H quinone dehydrogenase 1 Homo sapiens 4-8 35347544-8 2022 The NQO1 exhibit suppression of chemical-mediated carcinogenesis by various properties of NQO1 which includes, detoxification of quinone scavenger of superoxide anion radical, antioxidant enzyme, protein stabilizer. quinone 129-136 NAD(P)H quinone dehydrogenase 1 Homo sapiens 90-94 35092719-6 2022 Further in vitro results demonstrated that compared with control cells exposed to same 1,4-benzoquinone (1,4-BQ, an important active metabolite of benzene) concentration, Evi1 downregulation significantly reduced cell proliferation, and disrupted cell viability, apoptosis, erythroid and megakaryotic cell differentiation and cell cycle. quinone 87-103 MDS1 and EVI1 complex locus Mus musculus 171-175 35092719-6 2022 Further in vitro results demonstrated that compared with control cells exposed to same 1,4-benzoquinone (1,4-BQ, an important active metabolite of benzene) concentration, Evi1 downregulation significantly reduced cell proliferation, and disrupted cell viability, apoptosis, erythroid and megakaryotic cell differentiation and cell cycle. quinone 105-111 MDS1 and EVI1 complex locus Mus musculus 171-175 35092719-7 2022 Additionally, down-regulation of Evi1 suppressed phosphoinositide 3-kinase (PI3K)/mTOR signalling pathway and elevated its target gene Serpinb2 following 1,4-BQ exposure. quinone 154-160 MDS1 and EVI1 complex locus Mus musculus 33-37 35092719-7 2022 Additionally, down-regulation of Evi1 suppressed phosphoinositide 3-kinase (PI3K)/mTOR signalling pathway and elevated its target gene Serpinb2 following 1,4-BQ exposure. quinone 154-160 phosphoinositide-3-kinase regulatory subunit 1 Mus musculus 49-74 35092719-7 2022 Additionally, down-regulation of Evi1 suppressed phosphoinositide 3-kinase (PI3K)/mTOR signalling pathway and elevated its target gene Serpinb2 following 1,4-BQ exposure. quinone 154-160 mechanistic target of rapamycin kinase Mus musculus 82-86 35092719-7 2022 Additionally, down-regulation of Evi1 suppressed phosphoinositide 3-kinase (PI3K)/mTOR signalling pathway and elevated its target gene Serpinb2 following 1,4-BQ exposure. quinone 154-160 serine (or cysteine) peptidase inhibitor, clade B, member 2 Mus musculus 135-143 35092719-10 2022 In conclusion, our data revealed that Evi1 downregulation aggravated the inhibition of cell proliferation and arrested cells in the G0/G1 phase when exposed to 1,4-BQ, potentially by inactivating the PI3K/mTOR pathway and upregulating downstream target gene Serpinb2. quinone 160-166 MDS1 and EVI1 complex locus Mus musculus 38-42 35092719-10 2022 In conclusion, our data revealed that Evi1 downregulation aggravated the inhibition of cell proliferation and arrested cells in the G0/G1 phase when exposed to 1,4-BQ, potentially by inactivating the PI3K/mTOR pathway and upregulating downstream target gene Serpinb2. quinone 160-166 mechanistic target of rapamycin kinase Mus musculus 205-209 35092719-10 2022 In conclusion, our data revealed that Evi1 downregulation aggravated the inhibition of cell proliferation and arrested cells in the G0/G1 phase when exposed to 1,4-BQ, potentially by inactivating the PI3K/mTOR pathway and upregulating downstream target gene Serpinb2. quinone 160-166 serine (or cysteine) peptidase inhibitor, clade B, member 2 Mus musculus 258-266 35090502-2 2022 NAD(P)H: quinone oxidoreductase 1 (NQO1) protects cells from oxidative stress and toxic quinone damage. quinone 88-95 NAD(P)H dehydrogenase, quinone 1 Mus musculus 35-39 2736717-5 1989 The microsome-mediated oxidation of DES to quinone was inhibited by various compounds that also effectively inhibit the peroxidatic activity of cytochrome P-450. quinone 43-50 cytochrome P450 2A3-like Mesocricetus auratus 144-160 35209128-1 2022 The finding that the most common mitochondrial DNA mutation m.11778G>A/MT-ND4 (p.R340H) associated with Leber"s hereditary optic neuropathy (LHON) induces rotenone resistance has produced a long-standing debate, because it contrasts structural evidence showing that the ND4 subunit is far away from the quinone-reaction site in complex I, where rotenone acts. quinone 303-310 mitochondrially encoded NADH dehydrogenase 4 Homo sapiens 71-77 35209128-1 2022 The finding that the most common mitochondrial DNA mutation m.11778G>A/MT-ND4 (p.R340H) associated with Leber"s hereditary optic neuropathy (LHON) induces rotenone resistance has produced a long-standing debate, because it contrasts structural evidence showing that the ND4 subunit is far away from the quinone-reaction site in complex I, where rotenone acts. quinone 303-310 mitochondrially encoded NADH dehydrogenase 4 Homo sapiens 270-273 2549062-5 1989 The results suggest that cytochrome b562 is strongly interacting with the Qc quinone binding site. quinone 77-84 mitochondrially encoded cytochrome b Homo sapiens 25-37 35055166-5 2022 The calculations according to an "outer-sphere" electron transfer model show that the binding of CAM decreases the electron transfer distance from FMNH2 to quinone by 1-2 A. quinone 156-163 calmodulin 1 Homo sapiens 97-100 35024592-4 2022 In the presence of target tyrosinase, the phenolic hydroxyl groups in WVFY are rapidly converted to benzoquinone with the consumption of protons, which could be detected potentiometrically by bio-FETs. quinone 100-112 tyrosinase Homo sapiens 26-36 2512857-5 1989 DT-diaphorase reduced the naphthazarin-glutathione conjugate with an efficiency 5-fold lower than that observed with the parent quinone. quinone 128-135 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-13 2809587-1 1989 Serum albumin conjugates of histamine or tele-methylhistamine, a major catabolite, were prepared using 1,4-benzoquinone as the coupling agent and used to raise polyclonal antibodies in rabbits. quinone 103-119 albumin Oryctolagus cuniculus 0-13 2556468-5 1989 N-Acetylcysteine inhibited quinone-stimulated cytochrome C reduction at high concentrations. quinone 27-34 cytochrome c, somatic Homo sapiens 46-58 2551665-2 1989 Studies employing horseradish peroxidase and human myeloperoxidase have shown that in the presence of hydrogen peroxide phenol is converted to 4,4"-diphenoquinone and other covalent binding metabolites, whereas hydroquinone is converted solely to 1,4-benzoquinone. quinone 247-263 myeloperoxidase Homo sapiens 51-66 2536625-1 1989 Using ESR and spin-trapping techniques, it was found that synthetic 2-dimethylamino-3-chloro-1,4-naphthoquinone and the natural anticancer quinone daunomycin, when added to a system containing purified NADPH-cytochrome P-450 reductase, NADPH, ferric ions, and oxygen, (i) generated hydroxyl radicals and (ii) caused single-strand scission of supercoiled DNA of the plasmic pBR322. quinone 104-111 cytochrome p450 oxidoreductase Homo sapiens 202-234 2546562-2 1989 Moreover, our data strongly suggest that two catalytic sites are present, one for cytochrome c and one for quinone type compounds. quinone 107-114 cytochrome c, somatic Homo sapiens 82-94 2538447-5 1989 2-Chloro-5-hydroxyl-3-methyl-6-decyl-1,4-benzoquinone (2-CHMDB), an isomer of 3-CHMDB, shows much less inhibition of the mitochondrial cytochrome b-c1 complex, suggesting that the quinone binding site in this complex is highly specific. quinone 46-53 mitochondrially encoded cytochrome b Homo sapiens 135-147 2754251-3 1989 Two vapor fixatives, paraformaldehyde and p-benzoquinone, were tested and p-benzoquinone was found to preserve antigenicity of progesterone receptor (PR) and ovalbumin better than paraformaldehyde. quinone 74-88 progesterone receptor Homo sapiens 127-148 2754251-3 1989 Two vapor fixatives, paraformaldehyde and p-benzoquinone, were tested and p-benzoquinone was found to preserve antigenicity of progesterone receptor (PR) and ovalbumin better than paraformaldehyde. quinone 74-88 progesterone receptor Homo sapiens 150-152 2471583-3 1989 The resistant cells have a 24-fold increased level of DT-diaphorase activity, an enzyme that produces two electron reduction of quinone groups. quinone 128-135 NAD(P)H dehydrogenase, quinone 1 Mus musculus 54-67 2471583-4 1989 Dicoumarol, an inhibitor of DT-diaphorase, significantly inhibited crosslinking and cytotoxicity by mitomycin C in the quinone resistant cells. quinone 119-126 NAD(P)H dehydrogenase, quinone 1 Mus musculus 28-41 2562421-3 1989 Myeloperoxidase, isolated and purified from human PMNs, catalyzed the oxidation of eugenol to a reactive intermediate which is likely to be a quinone methide. quinone 142-149 myeloperoxidase Homo sapiens 0-15 2557982-23 1989 Thus, the combination of DT diaphorase and SOD is an efficient system for maintaining cDAoQ in its fully reduced state, a prerequisite for detoxication of the quinone by conjugation with sulfate or glucuronic acid. quinone 159-166 NAD(P)H quinone dehydrogenase 1 Homo sapiens 25-38 2557982-0 1989 On the mechanism of the Mn3(+)-induced neurotoxicity of dopamine:prevention of quinone-derived oxygen toxicity by DT diaphorase and superoxide dismutase. quinone 79-86 NAD(P)H quinone dehydrogenase 1 Homo sapiens 114-127 2557982-0 1989 On the mechanism of the Mn3(+)-induced neurotoxicity of dopamine:prevention of quinone-derived oxygen toxicity by DT diaphorase and superoxide dismutase. quinone 79-86 superoxide dismutase 1 Homo sapiens 132-152 2557982-14 1989 Furthermore, cDAoQ is no longer fully reduced and the steady-state ratio between the hydroquinone and the quinone is dependent on the amount of DT diaphorase present. quinone 90-97 NAD(P)H quinone dehydrogenase 1 Homo sapiens 144-157 18964661-4 1988 Applying a negative-going scan allows reduction of the quinone moiety in the C-5/C-12 positions. quinone 55-62 complement C5 Homo sapiens 77-85 2455523-6 1988 The results support the hypothesis that DT-diaphorase competes with one-electron quinone-reducing enzymes (such as cytochrome P-450 reductase) which generate auto-oxidizable semiquinones and forms more stable hydroquinones as an initial step in the detoxification of quinones in 10T1/2 cells. quinone 81-88 NAD(P)H dehydrogenase, quinone 1 Mus musculus 40-53 2460044-0 1988 Interaction of 1,4-benzoquinone and 2,4-dichlorophenoxyacetic acid with microsomal glutathione transferase from rat liver. quinone 15-31 glutathione S-transferase alpha 4 Rattus norvegicus 83-106 2537722-10 1989 Core protein II and the 14-kDa protein may contribute to the proton-conducting pathway(s) from the matrix aqueous phase to the primary protolytic redox center (protein-bound semiquinone/quinone couple). quinone 178-185 ubiquinol-cytochrome c reductase core protein 2 Bos taurus 0-15 2779948-3 1989 However, exposure of the cells to p-benzoquinone, hydroquinone or catechol, dihydroxy- and diketo-metabolites of benzene, resulted in a severe inhibition of interferon-alpha/beta production. quinone 34-48 interferon alpha Mus musculus 157-173 2779948-5 1989 Additional studies with p-benzoquinone indicated that inhibition of interferon-alpha/beta was reversible and could be abrogated by addition of reduced glutathione to the cell cultures. quinone 24-38 interferon alpha Mus musculus 68-84 2842335-8 1988 Regions of the cytochrome b protein affecting the inhibitor and putative quinone-binding sites have been defined. quinone 73-80 cytochrome b Saccharomyces cerevisiae S288C 15-27 2836381-3 1988 The results are in favor of two independent quinone binding sites at opposite surfaces of the membrane, topping one of the two hemes of cytochrome b each. quinone 44-51 mitochondrially encoded cytochrome b Homo sapiens 136-148 2831977-7 1988 During illumination of reaction center membranes supplemented with cytochrome c and a ubiquinone pool, there is a small but significant steady-state current which is considered to be caused by the re-oxidation of photoreduced quinone by molecular oxygen. quinone 89-96 cytochrome c, somatic Homo sapiens 67-79 2557982-23 1989 Thus, the combination of DT diaphorase and SOD is an efficient system for maintaining cDAoQ in its fully reduced state, a prerequisite for detoxication of the quinone by conjugation with sulfate or glucuronic acid. quinone 159-166 superoxide dismutase 1 Homo sapiens 43-46 3394171-1 1988 Adrenodoxin reductase (EC 1.18.1.2) catalyzes the oxidation of NADPH by 1.4-benzoquinone. quinone 72-88 ferredoxin reductase Homo sapiens 0-21 3112146-5 1987 Mimosine, a known competitive inhibitor of o-diphenoloxidase activity, also inhibited the new reaction competitively, suggesting that both the observed oxidative dimerization and the conventional quinone production are catalyzed by the same active site copper of tyrosinase. quinone 196-203 tyrosinase Homo sapiens 263-273 3151071-0 1988 DT-diaphorase-catalyzed two-electron reduction of various p-benzoquinone- and 1,4-naphthoquinone epoxides. quinone 58-72 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-13 3620453-7 1987 Myxothiazole and antimycin which inhibit the quinonol oxidation and quinone reduction sites, respectively, in the bc1 complex also inhibit electron transport from ETF-QO through the complex according to current models of the Q-cycle (Rich, P.R. quinone 68-75 electron transfer flavoprotein dehydrogenase Homo sapiens 163-169 3806571-7 1986 The Fe(III) chelate of daunomycin is however reduced by ferredoxin reductase and NADPH to the Fe(III) chelate of 7-deoxydaunomycinone, suggesting that quinone reduction of the chelate to the quinone methide has occurred. quinone 151-158 ferredoxin reductase Mus musculus 56-76 3036820-4 1987 The reoxidation of the endogenous quinone proceeded at a rate comparable to that of the rapidly reacting cytochrome b and appeared to be complete within 100 ms. quinone 34-41 cytochrome b Saccharomyces cerevisiae S288C 105-117 3601232-1 1987 The effect of 1,4-benzoquinone (BQ) on type A and B monoamine oxidase (MAO-A and -B) in human brain synaptosomes was examined. quinone 14-30 monoamine oxidase A Homo sapiens 71-83 3601232-1 1987 The effect of 1,4-benzoquinone (BQ) on type A and B monoamine oxidase (MAO-A and -B) in human brain synaptosomes was examined. quinone 32-34 monoamine oxidase A Homo sapiens 71-83 3601232-2 1987 MAO-A was found to be markedly inhibited by BQ competitively with the substrate, kynuramine, while MAO-B was less sensitive to this inhibitor and the inhibition was non-competitive with the substrate. quinone 44-46 monoamine oxidase A Rattus norvegicus 0-5 3601232-3 1987 The Ki value of MAO-A (9.62 +/- 0.35 microM) was much smaller than the Km value of the enzyme with the substrate (56.3 +/- 3.5 microM) or the Ki value of MAO-B with BQ (20.3 +/- 0.9 microM). quinone 165-167 monoamine oxidase A Rattus norvegicus 16-21 3601232-3 1987 The Ki value of MAO-A (9.62 +/- 0.35 microM) was much smaller than the Km value of the enzyme with the substrate (56.3 +/- 3.5 microM) or the Ki value of MAO-B with BQ (20.3 +/- 0.9 microM). quinone 165-167 monoamine oxidase B Rattus norvegicus 154-159 3601232-4 1987 The inhibition of MAO-A by BQ was also confirmed by the use of platelet mitochondria and clonal rat pheochromocytoma PC12h cells as enzyme sources. quinone 27-29 monoamine oxidase A Rattus norvegicus 18-23 3601232-5 1987 The inhibition of MAO activity by BQ proved to be reversible: the inhibited enzyme activity could be recovered by column chromatography on Sephadex G-25. quinone 34-36 monoamine oxidase A Rattus norvegicus 18-21 3576723-0 1987 [Characteristics of the interaction of adrenal lipoamide dehydrogenase with physiological and quinone electron acceptors]. quinone 94-101 dihydrolipoamide dehydrogenase Homo sapiens 47-70 3576723-1 1987 Lipoamide dehydrogenase (EC 1.6.4.3) from the ketoglutarate dehydrogenase complex of adrenals catalyzes the oxidation of NADH by lipoamide and quinone compounds according to the "ping-pong" scheme. quinone 143-150 dihydrolipoamide dehydrogenase Homo sapiens 0-23 3019394-11 1986 Addition of quinone homologues and analogues extended the plateau phase in the reduction of cytochrome b, but exogenous quinones did not equilibrate rapidly with cytochrome b. quinone 12-19 mitochondrially encoded cytochrome b Homo sapiens 92-104 3761306-2 1986 We found that stypoldione binds covalently to sulfhydryl groups of thiol-containing compounds via addition of sulfur to the C-4" position of the quinone ring. quinone 145-152 complement C4A (Rodgers blood group) Homo sapiens 124-127 3023600-0 1986 Interactions of anticancer quinone drugs, aclacinomycin A, adriamycin, carbazilquinone, and mitomycin C, with NADPH-cytochrome P-450 reductase, xanthine oxidase and oxygen. quinone 27-34 cytochrome p450 oxidoreductase Homo sapiens 110-142 3023600-1 1986 The properties of the interactions of anticancer quinone drugs, aclacinomycin A, adriamycin, carbazilquinone, and mitomycin C with nicotinamide adenine dinucleotide phosphate (NADPH)-cytochrome P-450 reductase and xanthine oxidase under anaerobic and aerobic conditions were studied. quinone 49-56 cytochrome p450 oxidoreductase Homo sapiens 131-209 3028490-4 1987 Glutathione reductase (EC 1.6.4.2) in the presence of NADPH and oxidised glutathione, and dihydrolipoamide dehydrogenase (EC 1.8.1.4) with NADH and lipoamide, are found to accelerate the radical decay by reducing the quinone or semiquinone. quinone 217-224 glutathione-disulfide reductase Homo sapiens 0-21 3028490-5 1987 DT-diaphorase (EC 1.6.99.2) in the presence of NAD(P)H can also achieve this by reducing the quinone directly. quinone 93-100 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-13 3022817-7 1986 Although the myeloperoxidase-catalyzed oxidation of DMA at pH 7 in the presence of Cl- gave only the cation radical of DMA, a fairly large amount of p-benzoquinone was obtained as a product. quinone 149-163 myeloperoxidase Homo sapiens 13-28 3097880-1 1986 This rapid and sensitive method for localizing tyrosinase in polyacrylamide slab gels is based on the condensation of Bestthorn"s hydrazone (3 methyl-2-benzothiazolinone hydrazone hydrochloride) with the quinone obtained by enzymatic oxidation of phenol. quinone 204-211 tyrosinase Homo sapiens 47-57 3806571-7 1986 The Fe(III) chelate of daunomycin is however reduced by ferredoxin reductase and NADPH to the Fe(III) chelate of 7-deoxydaunomycinone, suggesting that quinone reduction of the chelate to the quinone methide has occurred. quinone 191-198 ferredoxin reductase Mus musculus 56-76 3956487-5 1986 The quinone products of oxidation of L-dopa were responsible for the time-dependent inactivation of DHPR. quinone 4-11 quinoid dihydropteridine reductase Homo sapiens 100-104 3013725-1 1986 The linear, 6397-base pair (bp), mitochondrial S-1 DNA molecule from maize contains a 420-bp segment that is homologous with the chloroplast gene (psbA) that codes for the quinone binding protein of photosystem II. quinone 172-179 photosystem II protein D1 Zea mays 147-151 2419449-3 1986 A histamine-bovine serum albumin conjugate was prepared using 1,4-benzoquinone as the coupling agent and was employed to immunize mice for the preparation of monoclonal antibodies against histamine. quinone 62-78 albumin Mus musculus 19-32 2419622-1 1986 The effects of the dietary administration of four anticarcinogenic sulfur compounds on the activity of DT-diaphorase, a protective enzyme in quinone and quinoneimine detoxification, have been investigated in female CD-1 mice. quinone 141-148 NAD(P)H dehydrogenase, quinone 1 Mus musculus 103-116 2418539-0 1985 Inhibition of RNA synthesis and interleukin-2 production in lymphocytes in vitro by benzene and its metabolites, hydroquinone and p-benzoquinone. quinone 130-144 interleukin 2 Mus musculus 32-45 2418539-3 1985 Furthermore, 5 microM PBQ, the putative toxic metabolite of benzene, was shown to inhibit the formation of the T-cell growth factor IL-2. quinone 22-25 interleukin 2 Mus musculus 132-136 4015705-7 1985 The cell kill produced by both quinone agents was inhibited by catalase, but not by superoxide dismutase. quinone 31-38 catalase Mus musculus 63-71 2934259-0 1985 Inactivation of phi X174 DNA by the ortho-quinone derivative or its reduction product of the antitumor agent VP 16-213. quinone 42-49 host cell factor C1 Homo sapiens 109-114 2934259-1 1985 Biologically active phi X174 DNA is inactivated by the ortho-quinone derivative of the antitumor agent VP 16-213, but not by VP 16-213 itself, VP 16-213 phenoxy radical or aqueous decomposition product(s) of the ortho-quinone. quinone 61-68 host cell factor C1 Homo sapiens 103-108 2934259-3 1985 However, compared with the parent compound VP 16-213, reduction of the ortho-quinone results in substantial damage towards DNA. quinone 77-84 host cell factor C1 Homo sapiens 43-48 4052386-2 1985 Lactoperoxidase (LPO) has been covalently coupled to affinity-purified anti-ferritin antibodies with p-benzoquinone by a modified version of the method of Ternynck and Avrameas [Ternynck, T., & Avrameas, S. (1976) Ann. quinone 101-115 lactoperoxidase Homo sapiens 17-20 3892954-2 1985 We than discuss some evidences for the possible involvement of cytochrome P-450 in the processing of antigens (parallelism between carcinogenesis and immunogenicity induced by aromatic hydrocarbons, high inducibility of cytochrome P-450 dependent enzyme activity in human monocytes, significance of compounds with quinone structure as allergens and carcinogenic agents. quinone 314-321 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 63-79 4052386-2 1985 Lactoperoxidase (LPO) has been covalently coupled to affinity-purified anti-ferritin antibodies with p-benzoquinone by a modified version of the method of Ternynck and Avrameas [Ternynck, T., & Avrameas, S. (1976) Ann. quinone 101-115 lactoperoxidase Homo sapiens 0-15 3892954-2 1985 We than discuss some evidences for the possible involvement of cytochrome P-450 in the processing of antigens (parallelism between carcinogenesis and immunogenicity induced by aromatic hydrocarbons, high inducibility of cytochrome P-450 dependent enzyme activity in human monocytes, significance of compounds with quinone structure as allergens and carcinogenic agents. quinone 314-321 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 220-236 6202430-2 1984 The metabolites of benzene produced in bone marrow cells by the microsomal cytochrome P-450 are thought to be phenol, catechol, hydroquinone and p-benzoquinone (Andrews et al., Life Sci., 25 (1979) 567; Irons et al., Chem.-Biol. quinone 145-159 cytochrome P-450 Oryctolagus cuniculus 75-91 6745417-0 1984 The effects of quinone analogues on cytochrome b6 reduction and oxidation in a reconstituted system. quinone 15-22 mitochondrially encoded cytochrome b Homo sapiens 36-48 6523136-7 1984 These partially purified isoenzymes were used for the kinetic analysis of GST inhibition by 2,4-dichlorophenoxyalkyl acid and 1,4-benzoquinone, using Lineweaver--Burk plots. quinone 126-142 hematopoietic prostaglandin D synthase Rattus norvegicus 74-77 6327677-16 1984 These results suggest either that a myxothiazol-induced conformational change in cytochrome b is transmitted to a quinone binding site on the iron-sulfur protein, or that there is a quinone binding site which consists of peptide domains from both cytochrome b and iron-sulfur protein. quinone 114-121 cytochrome b Saccharomyces cerevisiae S288C 81-93 6327677-16 1984 These results suggest either that a myxothiazol-induced conformational change in cytochrome b is transmitted to a quinone binding site on the iron-sulfur protein, or that there is a quinone binding site which consists of peptide domains from both cytochrome b and iron-sulfur protein. quinone 182-189 cytochrome b Saccharomyces cerevisiae S288C 247-259 6324866-8 1984 In the absence of inhibitors the initial reduction of cytochrome b (via both pathways) is followed by a net oxidation which is the resultant of a continuing reduction (together with the reduction of the Rieske [2Fe-2S] cluster) and an oxidation (via the antimycin-sensitive site) by quinone. quinone 283-290 cytochrome b Bos taurus 54-66 6324808-6 1984 The 4-(N,N-dimethylamino)phenoxyl radical is quite unstable and decays in a pseudo-first order reaction (k = 0.4 sec-1 at pH 8.5, 22 degrees) with the formation of p-benzoquinone and dimethylamine. quinone 164-178 secretory blood group 1, pseudogene Homo sapiens 113-118 6324808-12 1984 p-Benzoquinone rapidly reacts with DMAP (k2 = 2 X 10(4) M-1 sec-1) with the formation of the 4-(N,N-dimethylamino)phenoxyl and the semiquinone radicals. quinone 0-14 secretory blood group 1, pseudogene Homo sapiens 60-65 6626508-1 1983 2-Hydroxy-3-undecyl-1,4-naphthoquinone is a quinone analogue that inhibits mitochondrial respiration in the cytochrome b-c1 region with an apparent Ki of 2.5 X 10(-7) M. In electron transport particles, it prevents the reduction of cytochrome c1 by succinate but not its oxidation by oxygen and prevents oxidation of cytochrome b but not its reduction by succinate. quinone 31-38 mitochondrially encoded cytochrome b Homo sapiens 108-120 6579306-2 1983 A third analogue has an extra quinone function at C-8 of the oxazole analogue. quinone 30-37 homeobox C8 Homo sapiens 50-53 6537800-10 1984 The induction of both DNA single-strand and double-strand breaks by hydrolyzed benzoquinone mustard was significantly inhibited by the cell-protective enzymes superoxide dismutase and catalase. quinone 79-91 catalase Homo sapiens 184-192 6661246-1 1983 The quinone of E-diethylstilbestrol (DES), a postulated metabolic intermediate derived from DES, has been synthesized by oxidation of DES in chloroform using silver oxide. quinone 4-11 desmin Rattus norvegicus 37-40 6661246-1 1983 The quinone of E-diethylstilbestrol (DES), a postulated metabolic intermediate derived from DES, has been synthesized by oxidation of DES in chloroform using silver oxide. quinone 4-11 desmin Rattus norvegicus 92-95 6661246-1 1983 The quinone of E-diethylstilbestrol (DES), a postulated metabolic intermediate derived from DES, has been synthesized by oxidation of DES in chloroform using silver oxide. quinone 4-11 desmin Rattus norvegicus 92-95 6626508-1 1983 2-Hydroxy-3-undecyl-1,4-naphthoquinone is a quinone analogue that inhibits mitochondrial respiration in the cytochrome b-c1 region with an apparent Ki of 2.5 X 10(-7) M. In electron transport particles, it prevents the reduction of cytochrome c1 by succinate but not its oxidation by oxygen and prevents oxidation of cytochrome b but not its reduction by succinate. quinone 31-38 mitochondrially encoded cytochrome b Homo sapiens 317-329 6295407-0 1982 Generation of hydroxyl radical by anticancer quinone drugs, carbazilquinone, mitomycin C, aclacinomycin A and adriamycin, in the presence of NADPH-cytochrome P-450 reductase. quinone 45-52 cytochrome p450 oxidoreductase Homo sapiens 141-173 6615552-1 1983 Adriamycin toxicity is postulated to result from cytochrome P-450 reductase-catalyzed univalent reduction of the quinone to the semiquinone free radical intermediate. quinone 113-120 cytochrome p450 oxidoreductase Rattus norvegicus 49-75 6191666-2 1983 Chemiluminescence was augmented when the two-electron reduction of the quinone catalyzed by NAD(P)H:quinone reductase was inhibited by dicoumarol, thus underlining the protective function of this enzyme also known as DT-diaphorase. quinone 71-78 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 217-230 6848172-6 1983 The cytotoxic activity of hydrolyzed benzoquinone mustard was inhibited by either superoxide dismutase or catalase, while catalase but not superoxide dismutase inhibited the activity of benzoquinone mustard. quinone 37-49 catalase Mus musculus 106-114 6848172-6 1983 The cytotoxic activity of hydrolyzed benzoquinone mustard was inhibited by either superoxide dismutase or catalase, while catalase but not superoxide dismutase inhibited the activity of benzoquinone mustard. quinone 37-49 catalase Mus musculus 122-130 6848172-6 1983 The cytotoxic activity of hydrolyzed benzoquinone mustard was inhibited by either superoxide dismutase or catalase, while catalase but not superoxide dismutase inhibited the activity of benzoquinone mustard. quinone 186-198 catalase Mus musculus 122-130 6316886-3 1983 A new hypothesis for oestrogen action at the molecular level is that the phenolic moiety of an oestrogen is oxidized to the corresponding quinone methide which is rapidly reduced with, say, NADPH to regenerate the oestrogen; the feedback from the rapid consumption of oxidant and/or reductant in the target organs might be responsible for the local increase in RNA synthesis, and its consequent phenomena. quinone 138-145 2,4-dienoyl CoA reductase 1, mitochondrial Mus musculus 190-195 6295407-9 1982 From these results, the interactions of anticancer quinone drugs with NADPH-cytochrome P-450 reductase and oxygen, and the possible relations of the enzymes to the radical related actions of these drugs are discussed. quinone 51-58 cytochrome p450 oxidoreductase Homo sapiens 70-102 6815478-8 1982 This mechanism differs markedly from that for inhibition of drug metabolism by other quinones, such as menadione, in which accelerated electron flow through P-450 reductase to the quinone diverts reducing equivalents from cytochrome P-450. quinone 85-92 cytochrome P-450 Oryctolagus cuniculus 222-238 6282879-1 1982 A synthetic quinone, 5-n-undecyl-6-hydroxy-4,7-dioxobenzothiazole (UHDBT), inhibits electron transfer reactions in the cytochrome b-c1 segment of the mitochondrial respiratory chain. quinone 12-19 mitochondrially encoded cytochrome b Homo sapiens 119-131 6283813-5 1981 Superoxide production by NADPH-cytochrome P-450 reductase was maximal at a quinone single-electron reduction potential at -200 mV. quinone 75-82 cytochrome p450 oxidoreductase Homo sapiens 25-57 7066431-0 1982 [Affinity chromatography of menadione reductase on Sepharose with aminoaromatic and aminoaliphatic quinone ligands]. quinone 99-106 NAD(P)H quinone dehydrogenase 1 Homo sapiens 28-47 7066431-6 1982 It is assumed that an essential role in the adsorption mechanism belongs to dispersion forces and to formation of a molecular charge-transfer complex between the aminoaromatic quinone ligand and menadione reductase active center. quinone 176-183 NAD(P)H quinone dehydrogenase 1 Homo sapiens 195-214 7265115-4 1981 They can oxidize NADH into NAD+ through a nonenzymatic process, and, moreover, quinone from N2-methyl-9-hydroxyellipticine may undergo a nucleophilic attack, resulting in an irreversible binding of the drug to bovine serum albumin. quinone 79-86 albumin Mus musculus 217-230 6933553-2 1980 The present report concerns the enhancement of dicoumarol-inhibited NAD(P)H:quinone reductase [NAD(P)H dehydrogenase (quinone); NAD(P)H:(quinone acceptor) oxidoreductase, EC 1.6.99.2] activity in mouse tissues in response to dietary administration of BHA. quinone 118-125 crystallin, zeta Mus musculus 76-93 7263619-10 1980 In the presence of antimycin cytochrome b561 cannot equilibrate with the quinone and undergoes oxidation, while cytochrome b566 reequilibrates with the quinone and thus regains redox equilibrium with the fumarate succinate redox buffer. quinone 73-80 cytochrome b561 Homo sapiens 29-44 7263619-10 1980 In the presence of antimycin cytochrome b561 cannot equilibrate with the quinone and undergoes oxidation, while cytochrome b566 reequilibrates with the quinone and thus regains redox equilibrium with the fumarate succinate redox buffer. quinone 73-80 mitochondrially encoded cytochrome b Homo sapiens 29-41 7263619-10 1980 In the presence of antimycin cytochrome b561 cannot equilibrate with the quinone and undergoes oxidation, while cytochrome b566 reequilibrates with the quinone and thus regains redox equilibrium with the fumarate succinate redox buffer. quinone 152-159 mitochondrially encoded cytochrome b Homo sapiens 29-41 6260766-7 1980 These results indicate that this quinone derivative is a highly specific and potent inhibitor of electron transfer in the b-c1 segment of the respiratory chain. quinone 33-40 brain cytoplasmic RNA 1 Rattus norvegicus 122-126 520550-0 1979 Intracellular quinone reduction in Sporotrichum pulverulentum by a NAD(P)H:quinone oxidoreductase: possible role in vanillic acid catabolism. quinone 14-21 crystallin zeta Homo sapiens 75-97 6248123-0 1980 Spin-trapping and direct electron spin resonance investigations of the redox metabolism of quinone anticancer drugs. quinone 91-98 spindlin 1 Homo sapiens 34-38 34156-0 1979 NADPH cytochrome P-450 reductase activation of quinone anticancer agents to free radicals. quinone 47-54 cytochrome p450 oxidoreductase Homo sapiens 0-32 34156-1 1979 With NADPH as the electron donor, rat liver NADPH cytochrome P-450 reductase (NADPH:ferricytochrome oxidoreductase, EC 1.6.2.4) catalyzes the single-electron reduction of several quinone antibiotics to a semiquinone or free radical state. quinone 179-186 cytochrome p450 oxidoreductase Rattus norvegicus 44-76 7213837-6 1980 It is assumed that the specific binding of menadione reductase to the adsorbent is due to the formation of a complex between the oxidized enzyme and the quinone. quinone 153-160 NAD(P)H quinone dehydrogenase 1 Homo sapiens 43-62 227864-4 1979 Hence, we identify a single molecule of quinone, probably ubiquinone-10 in a special environment, as a major electron donor to ferricytochrome c2 in the ubiquinone cytochrome b-c2 oxidoreductase. quinone 40-47 mitochondrially encoded cytochrome b Homo sapiens 164-176 39633-4 1979 The data obtained are in favour of the idea that when illuminating the solutions of these pigments in ethanol containing pure p-benzoquinone at pH higher than the definite value, PhP initiation is conditioned by photochemical reaction of pigments with equilibrium amounts of hydroquinones or semiquinone always present in quinone solutions. quinone 126-140 N-acylsphingosine amidohydrolase 1 Homo sapiens 179-182 39633-4 1979 The data obtained are in favour of the idea that when illuminating the solutions of these pigments in ethanol containing pure p-benzoquinone at pH higher than the definite value, PhP initiation is conditioned by photochemical reaction of pigments with equilibrium amounts of hydroquinones or semiquinone always present in quinone solutions. quinone 133-140 N-acylsphingosine amidohydrolase 1 Homo sapiens 179-182 413870-1 1978 The quinone intermediates resulting from tyrosinase-mediated oxidation of tyrosine were evaluated as sulfhydryl reagent inhibitors of purified calf thymus DNA polymerase alpha in order to determine which of these might be cytotoxic. quinone 4-11 tyrosinase Bos taurus 41-51 23354-0 1977 Conjugation of p-benzoquinone treated enzymes with antibodies and Fab fragments. quinone 15-29 FA complementation group B Homo sapiens 66-69 737248-1 1978 The development of cytosolic DT-diaphorase--NAD(P)H dehydrogenase, quinone, EC 1.6.99.2--and its induction by benzo(a)pyrene has been studied in rat liver. quinone 67-74 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 29-42 195602-1 1977 Studies with a ubiA- menA- double quinone mutant. quinone 34-41 ENAH actin regulator Homo sapiens 21-25 195602-2 1977 A ubiA- menA- double quinone mutant of Escherichia coli K12 was constructed together with other isogenic strains lacking either ubiquinone or menaquinone. quinone 21-28 ENAH actin regulator Homo sapiens 8-12 403000-1 1977 A stable phenol, gamma-L-glutaminyl-4-hydroxybenzene (GHB), is oxidized by tyrosinase in the gill tissues of the mushroom Agaricus bisporus to a quinone and a second oxidation product which together suppress mitochondrial energy production and the synthesis of proteins and nucleic acids in the zygote, thus establishing dormancy in the spores. quinone 145-152 tyrosinase Mus musculus 75-85 850243-3 1977 Its oxidized form, the p-quinone, can be identified in small quantities in rat brain and mouse brain 1-3 h after 6-OHDA injection. quinone 23-32 POU domain, class 3, transcription factor 3 Mus musculus 95-104 403000-12 1977 These studies provide evidence that GHB exerts cytotoxicity specifically for cells that by their content of tyrosinase convert the phenol to the quinone. quinone 145-152 tyrosinase Mus musculus 108-118 1125287-0 1975 [Cytochrome b-559 photooxidation in the presence of carbonyl cyanide p-trifluorometh-oxyphenylhydrazone and 2,5-dibromo-3-methyl-6-isopropyl-p-benzoquinone or p-benzoquinone in three non-photosynthetic mutants of Chlamydomonas reinhardti (author"s transl)]. quinone 141-155 mitochondrially encoded cytochrome b Homo sapiens 1-13 166698-0 1975 [Interaction of rhodopsin with quinone]. quinone 31-38 rhodopsin Homo sapiens 16-25 4164898-7 1967 The possible occurrence of a cytochrome b oxidase and the requirement for a quinone are discussed, as well as the correlation between the abbreviated pathway and the energy generation by the cell. quinone 76-83 mitochondrially encoded cytochrome b Homo sapiens 29-41 4403564-2 1972 The ability of erythrocyte hemolysates to decarboxylate DOPA is associated with interaction between DOPA and methemoglobin; the ferriheme protein is reduced and DOPA is decarboxylated, probably after oxidation to a quinone intermediate. quinone 215-222 hemoglobin subunit gamma 2 Homo sapiens 109-122 4396182-1 1970 V. Difference in the mechanism of quinone reduction by the NADH dehydrogenase and the NAD(P)H dehydrogenase (DT-diaphorase). quinone 34-41 NAD(P)H quinone dehydrogenase 1 Homo sapiens 109-122 13923510-0 1962 [Influence of quinone derivatives on insulin, glucagon, and insulinase. quinone 14-21 insulin degrading enzyme Homo sapiens 60-70 13923510-2 1962 Influence of quinone derivatives on insulinase]. quinone 13-20 insulin degrading enzyme Homo sapiens 36-46 13923508-0 1962 [Influence of quinone derivatives on insulin, glucagon, and insulinase. quinone 14-21 insulin degrading enzyme Homo sapiens 60-70 14068698-0 1963 INFLUENCE OF QUINONE DERIVATIVES ON INSULIN, GLUCAGON, AND INSULINASE. quinone 13-20 insulin degrading enzyme Homo sapiens 59-69 33983712-2 2021 To develop a fluorescent NQO1 probe with practicality, we investigated benzo-rosol fluorophores linked with a known self-immolative quinone substrate. quinone 132-139 NAD(P)H quinone dehydrogenase 1 Homo sapiens 25-29 13923508-0 1962 [Influence of quinone derivatives on insulin, glucagon, and insulinase. quinone 14-21 insulin Homo sapiens 37-44 18894930-0 1948 The mechanism of the clotting of fibrinogen with formaldehyde and quinone; interactions between formaldehyde and thrombin. quinone 66-73 fibrinogen beta chain Homo sapiens 33-43 13923508-2 1962 Influence of quinone derivatives on the blood sugar decreasing action of insulin]. quinone 13-20 insulin Homo sapiens 73-80 13923509-0 1962 [Influence of quinone derivatives on insulin, glucagon, and insulinase. quinone 14-21 insulin Homo sapiens 37-44 13923509-0 1962 [Influence of quinone derivatives on insulin, glucagon, and insulinase. quinone 14-21 insulin degrading enzyme Homo sapiens 60-70 34040527-9 2021 Both EPR and LCMS studies confirmed a significant increase in the ROS production in the NQO2 overexpressing cells due to the fast reduction of quinone into quinol that can re-oxidize to form superoxide radicals. quinone 143-150 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 88-92 33852798-2 2021 The 1,4-benzoquinone scaffold possesses antioxidant potential along with AChE inhibition activity in various neurological disorders. quinone 4-20 acetylcholinesterase Mus musculus 73-77 33852798-3 2021 To design novel and potent selective 1,4-benzoquinone analogues as cholinesterase inhibitors, a ligand-based drug design strategy was followed to develop a 3D quantitative structure-selectivity relationship (QSSR) model. quinone 37-53 acetylcholinesterase Mus musculus 67-81 33961949-0 2021 Polybrominated diphenyl ethers quinone exhibits neurotoxicity by inducing DNA damage, cell cycle arrest, apoptosis and p53-driven adaptive response in microglia BV2 cells. quinone 31-38 transformation related protein 53, pseudogene Mus musculus 119-122 33122156-3 2020 Here, we report that Emodin, a CO anthraquinone, inhibits the enzymatic activity of NADPH-Quinone reductase, which is an intracellular enzyme fundamentally involved in the detoxification of quinone containing compounds. quinone 40-47 crystallin zeta Rattus norvegicus 84-107 33071125-5 2021 Subsequently, the observed activities in lymphocytes were verified using human HL-60 (p53 null) and TK6 (p53 wild-type) cells via 1,4-benzoquinone (1,4-BQ) treatment and miR-222 interferences. quinone 130-146 tumor protein p53 Homo sapiens 86-89 33071125-5 2021 Subsequently, the observed activities in lymphocytes were verified using human HL-60 (p53 null) and TK6 (p53 wild-type) cells via 1,4-benzoquinone (1,4-BQ) treatment and miR-222 interferences. quinone 130-146 tumor protein p53 Homo sapiens 105-108 33071125-5 2021 Subsequently, the observed activities in lymphocytes were verified using human HL-60 (p53 null) and TK6 (p53 wild-type) cells via 1,4-benzoquinone (1,4-BQ) treatment and miR-222 interferences. quinone 148-154 tumor protein p53 Homo sapiens 105-108 33071125-9 2021 Our in vitro validation studies using both cell lines indicate that 1,4-BQ exposure increased expression of miR-222 and Comet tail length but decreased DRC. quinone 68-74 microRNA 222 Homo sapiens 108-115 33071125-12 2021 In conclusion, our in vivo observations were confirmed by in vitro studies showing that BZ/1,4-BQ exposures caused genotoxicity and high expression of miR-222 which obstructed expression of the MDM2-p53 axis that led to failed activation of p53, abnormal DRC and serious biological consequences. quinone 91-97 microRNA 222 Homo sapiens 151-158 33071125-12 2021 In conclusion, our in vivo observations were confirmed by in vitro studies showing that BZ/1,4-BQ exposures caused genotoxicity and high expression of miR-222 which obstructed expression of the MDM2-p53 axis that led to failed activation of p53, abnormal DRC and serious biological consequences. quinone 91-97 MDM2 proto-oncogene Homo sapiens 194-198 33071125-12 2021 In conclusion, our in vivo observations were confirmed by in vitro studies showing that BZ/1,4-BQ exposures caused genotoxicity and high expression of miR-222 which obstructed expression of the MDM2-p53 axis that led to failed activation of p53, abnormal DRC and serious biological consequences. quinone 91-97 tumor protein p53 Homo sapiens 199-202 33071125-12 2021 In conclusion, our in vivo observations were confirmed by in vitro studies showing that BZ/1,4-BQ exposures caused genotoxicity and high expression of miR-222 which obstructed expression of the MDM2-p53 axis that led to failed activation of p53, abnormal DRC and serious biological consequences. quinone 91-97 tumor protein p53 Homo sapiens 241-244 33486434-2 2021 The method is based on the oxidation of pyrocatechol (PC) to give quinone form which by oxidative coupling with aminyl radical of 4-aminoantipyrine (4-AAP) resulting from H2O2/CAT to produce a pink colored quinone-imine product with lambdamax = 530 nm in a 100 mmol/L of tris buffer of pH 9.8 at room temperature (30 C). quinone 66-73 catalase Homo sapiens 176-179 33847861-5 2021 Strain HHU K3-1 T was found to contain ubiquinone-10 as the predominant quinone and the major polar lipids were diphosphatidylglycerol (DPG), phosphatidylethanolamine (PE), phosphatidylglycerol (PG) and sphingoglycolipid (SGL). quinone 42-49 keratin 31 Homo sapiens 11-15 33190980-4 2021 We first confirmed that PCB quinone induces cancerous HeLa and MDA-MB-231 cells necroptosis via the phosphorylation of mixed lineage kinase domain-like MLKL (p-MLKL). quinone 28-35 mixed lineage kinase domain like pseudokinase Homo sapiens 152-156 33190980-4 2021 We first confirmed that PCB quinone induces cancerous HeLa and MDA-MB-231 cells necroptosis via the phosphorylation of mixed lineage kinase domain-like MLKL (p-MLKL). quinone 28-35 mixed lineage kinase domain like pseudokinase Homo sapiens 160-164 33190980-5 2021 Then, we found that PCB quinone-stimulated p-MLKL enhances exosome biogenesis and secretion. quinone 24-31 mixed lineage kinase domain like pseudokinase Homo sapiens 45-49 33190980-6 2021 Exosome interacts with p-MLKL and releases p-MLKL to the outside of the cell, and ultimately alleviating PCB quinone-induced necroptosis. quinone 109-116 mixed lineage kinase domain like pseudokinase Homo sapiens 25-29 33190980-7 2021 The inhibition of exosome secretion by GW4869 significantly elevated necroptotic level, indicating the establishment of a short negative feedback loop of MLKL-exosome secretion upon PCB quinone challenge. quinone 186-193 mixed lineage kinase domain like pseudokinase Homo sapiens 154-158 33650850-3 2021 We previously proposed that the matrix-side interfacial region of the 49 kDa, ND1, PSST, and 39 kDa subunits, which is covered by a loop connecting transmembrane helices (TMHs) 1 and 2 of ND3, may be the area for entry of some bulky ligands into the quinone reaction cavity. quinone 250-257 mitochondrially encoded NADH dehydrogenase 1 Homo sapiens 78-81 33650850-3 2021 We previously proposed that the matrix-side interfacial region of the 49 kDa, ND1, PSST, and 39 kDa subunits, which is covered by a loop connecting transmembrane helices (TMHs) 1 and 2 of ND3, may be the area for entry of some bulky ligands into the quinone reaction cavity. quinone 250-257 NADH:ubiquinone oxidoreductase core subunit S7 Homo sapiens 83-87 33650850-3 2021 We previously proposed that the matrix-side interfacial region of the 49 kDa, ND1, PSST, and 39 kDa subunits, which is covered by a loop connecting transmembrane helices (TMHs) 1 and 2 of ND3, may be the area for entry of some bulky ligands into the quinone reaction cavity. quinone 250-257 mitochondrially encoded NADH dehydrogenase 3 Homo sapiens 188-191 33650850-9 2021 Altogether, this study provides direct evidence that the quinone reaction cavity is indeed accessible from the proposed matrix-side region covered by the ND3 TMH1-2 loop. quinone 57-64 mitochondrially encoded NADH dehydrogenase 3 Homo sapiens 154-157 33475376-0 2021 Probing Molecular-Scale Oxidative Generation of Quinone Methides and Their Transformation Using Tip-Enhanced Raman Spectroscopy. quinone 48-55 TOR signaling pathway regulator Homo sapiens 96-99 32716144-2 2021 Herein, supported by a proposed combination of 1 and quinone drug idebenone, we rationally designed novel 1 -based MTDLs targeting Abeta and oxidative pathways. quinone 53-60 amyloid beta precursor protein Homo sapiens 131-136 33321763-8 2020 Addition of MPO also resulted in upregulation of the antioxidant gene, NAD(P)H:quinone acceptor oxidoreductase 1. quinone 79-86 myeloperoxidase Mus musculus 12-15 33140638-4 2020 In this work, we describe a voltammetric pH sensor that uses a three-dimensional (3D)-printed graphene/poly(lactic acid) filament electrode that is pretreated to introduce quinone functional groups to the graphene surface. quinone 172-179 phenylalanine hydroxylase Homo sapiens 41-43 33141566-3 2020 Herein, by merging quinone methide and a fluorogenic enzyme substrate, we report an activatable self-immobilizing near-infrared probe for the in vitro and in vivo imaging of GGT activity. quinone 19-26 gamma-glutamyltransferase 1 Mus musculus 174-177 32859750-11 2020 Our simulations also reveal that the redox state of the quinone pool is the primary determinant of free radical production by SDH. quinone 56-63 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 126-129 32913139-4 2020 For a long time both enzymes have been considered as key detoxifying enzymes in quinone metabolism, but more recent findings point to a more toxifying function of NQO2, particularly with respect to ortho-quinones. quinone 80-87 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 163-167 32913139-5 2020 In fact, during the reduction of substrates, NQO2 generates fairly unstable intermediates that reoxidize immediately back to the original quinone, creating a futile cycle, the byproducts of which are deleterious reactive oxygen species. quinone 138-145 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 45-49 32645459-0 2020 lncRNA-OBFC2A targeted to Smad3 regulated Cyclin D1 influences cell cycle arrest induced by 1,4-benzoquinone. quinone 92-108 nucleic acid binding protein 1 Homo sapiens 7-13 32836058-6 2020 Meanwhile, APAP was released at acidic tumor environment and subsequently activated by overexpressed tyrosinase in the presence of O2 to produce cytotoxic benzoquinone metabolites (AOBQ). quinone 155-167 tyrosinase Homo sapiens 101-111 32972993-3 2020 Quinone binds at three positions along the quinone cavity, as does the inhibitor rotenone that also binds within subunit ND4. quinone 0-7 mitochondrially encoded NADH dehydrogenase 4 Homo sapiens 121-124 32972993-3 2020 Quinone binds at three positions along the quinone cavity, as does the inhibitor rotenone that also binds within subunit ND4. quinone 43-50 mitochondrially encoded NADH dehydrogenase 4 Homo sapiens 121-124 32868290-6 2020 Mechanistically, we show that products of NRF2 target genes metabolize the quinone-containing geldanamycin compounds into more potent HSP90 inhibitors, which enhances their cytotoxicity while simultaneously restricting the synthetic lethal effect to cells with aberrant NRF2 activity. quinone 75-82 NFE2 like bZIP transcription factor 2 Homo sapiens 42-46 32868290-6 2020 Mechanistically, we show that products of NRF2 target genes metabolize the quinone-containing geldanamycin compounds into more potent HSP90 inhibitors, which enhances their cytotoxicity while simultaneously restricting the synthetic lethal effect to cells with aberrant NRF2 activity. quinone 75-82 heat shock protein 90 alpha family class A member 1 Homo sapiens 134-139 32868290-6 2020 Mechanistically, we show that products of NRF2 target genes metabolize the quinone-containing geldanamycin compounds into more potent HSP90 inhibitors, which enhances their cytotoxicity while simultaneously restricting the synthetic lethal effect to cells with aberrant NRF2 activity. quinone 75-82 NFE2 like bZIP transcription factor 2 Homo sapiens 270-274 32645459-5 2020 In vitro study, results showed that benzene metabolic, 1,4-Benzoquinone (1,4-BQ), induced cell cycle arrest at the G1 phase accompanied with decreased expression of Cyclin D1 in a dose-dependently manner. quinone 55-71 cyclin D1 Homo sapiens 165-174 32645459-5 2020 In vitro study, results showed that benzene metabolic, 1,4-Benzoquinone (1,4-BQ), induced cell cycle arrest at the G1 phase accompanied with decreased expression of Cyclin D1 in a dose-dependently manner. quinone 73-79 cyclin D1 Homo sapiens 165-174 32645459-6 2020 Interestingly, lncRNA-OBFC2A overexpression was found in AHH-1 cells treated with 1,4-BQ and while interference with lncRNA-OBFC2A, the expression of Cyclin D1 were reversed. quinone 82-88 nucleic acid binding protein 1 Homo sapiens 22-28 32645459-6 2020 Interestingly, lncRNA-OBFC2A overexpression was found in AHH-1 cells treated with 1,4-BQ and while interference with lncRNA-OBFC2A, the expression of Cyclin D1 were reversed. quinone 82-88 nucleic acid binding protein 1 Homo sapiens 124-130 32645459-6 2020 Interestingly, lncRNA-OBFC2A overexpression was found in AHH-1 cells treated with 1,4-BQ and while interference with lncRNA-OBFC2A, the expression of Cyclin D1 were reversed. quinone 82-88 cyclin D1 Homo sapiens 150-159 32645459-9 2020 Thus, these findings indicate that lncRNA-OBFC2A targeted to Smad3 regulated cyclin D1 influences cell cycle arrest induced by 1,4-BQ. quinone 127-133 nucleic acid binding protein 1 Homo sapiens 42-48 32645459-9 2020 Thus, these findings indicate that lncRNA-OBFC2A targeted to Smad3 regulated cyclin D1 influences cell cycle arrest induced by 1,4-BQ. quinone 127-133 SMAD family member 3 Homo sapiens 61-66 32645459-9 2020 Thus, these findings indicate that lncRNA-OBFC2A targeted to Smad3 regulated cyclin D1 influences cell cycle arrest induced by 1,4-BQ. quinone 127-133 cyclin D1 Homo sapiens 77-86 32478940-6 2020 We found that 1,4-BQ significantly decreased LC levels and downregulated Cpt1a, Cpt2, Crat, Hadha, Acaa2, and Acadvl mRNA expression in K562 cells. quinone 14-20 acyl-CoA dehydrogenase very long chain Homo sapiens 110-116 32478940-7 2020 Subsequent assays confirmed that 1,4-BQ decreased cell viability and increased apoptosis and caspase-3, -8, and -9 activities. quinone 33-39 caspase 3 Homo sapiens 93-114 32478940-10 2020 Cotreatment with LC (500 mumol/L) relieved these alterations by reducing oxidative stress and increasing the protein expression levels of Cpt1a and Hadha, particularly in the 20 mumol/L 1,4-BQ group. quinone 186-192 carnitine palmitoyltransferase 1A Homo sapiens 138-143 32478940-10 2020 Cotreatment with LC (500 mumol/L) relieved these alterations by reducing oxidative stress and increasing the protein expression levels of Cpt1a and Hadha, particularly in the 20 mumol/L 1,4-BQ group. quinone 186-192 hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha Homo sapiens 148-153 32645459-0 2020 lncRNA-OBFC2A targeted to Smad3 regulated Cyclin D1 influences cell cycle arrest induced by 1,4-benzoquinone. quinone 92-108 SMAD family member 3 Homo sapiens 26-31 32645459-0 2020 lncRNA-OBFC2A targeted to Smad3 regulated Cyclin D1 influences cell cycle arrest induced by 1,4-benzoquinone. quinone 92-108 cyclin D1 Homo sapiens 42-51 32906170-11 2020 Probably via spontaneous oxidation, DOPAL potently oligomerizes and forms quinone-protein adducts with ("quinonizes") alpha-synuclein (AS), a major constituent in Lewy bodies, and DOPAL-induced AS oligomers impede vesicular storage. quinone 74-81 synuclein alpha Homo sapiens 118-133 32724991-9 2020 The IC50 value of 0.89 mg L-1 for BQ was obtained using K3[Fe(CN)6] as the single mediator. quinone 34-36 L1 cell adhesion molecule Homo sapiens 26-29 32538547-6 2020 RESULTS: DA modifies alpha-syn with the addition of dopamine-quinone (DAQ) into lysine sites of alpha-syn in vitro and the addition of DAQ and DOPAL (3,4-dihydroxyphenylacetaldehyde) in plasma samples. quinone 61-68 synuclein alpha Homo sapiens 21-30 32538547-6 2020 RESULTS: DA modifies alpha-syn with the addition of dopamine-quinone (DAQ) into lysine sites of alpha-syn in vitro and the addition of DAQ and DOPAL (3,4-dihydroxyphenylacetaldehyde) in plasma samples. quinone 61-68 synuclein alpha Homo sapiens 96-105 32449459-3 2020 GI-D introns belong to the rarest group with only 17 described to date, including only one with a putative role reported in fungi, where it would interfere with an adaptive response in the cytochrome b (COB) gene to quinone outside inhibitor (QoI) fungicide resistance. quinone 216-223 mitochondrially encoded cytochrome b Homo sapiens 189-201 32449459-3 2020 GI-D introns belong to the rarest group with only 17 described to date, including only one with a putative role reported in fungi, where it would interfere with an adaptive response in the cytochrome b (COB) gene to quinone outside inhibitor (QoI) fungicide resistance. quinone 216-223 mitochondrially encoded cytochrome b Homo sapiens 203-206 32478940-6 2020 We found that 1,4-BQ significantly decreased LC levels and downregulated Cpt1a, Cpt2, Crat, Hadha, Acaa2, and Acadvl mRNA expression in K562 cells. quinone 14-20 carnitine palmitoyltransferase 1A Homo sapiens 73-78 32478940-6 2020 We found that 1,4-BQ significantly decreased LC levels and downregulated Cpt1a, Cpt2, Crat, Hadha, Acaa2, and Acadvl mRNA expression in K562 cells. quinone 14-20 carnitine palmitoyltransferase 2 Homo sapiens 80-84 32478940-6 2020 We found that 1,4-BQ significantly decreased LC levels and downregulated Cpt1a, Cpt2, Crat, Hadha, Acaa2, and Acadvl mRNA expression in K562 cells. quinone 14-20 carnitine O-acetyltransferase Homo sapiens 86-90 32478940-6 2020 We found that 1,4-BQ significantly decreased LC levels and downregulated Cpt1a, Cpt2, Crat, Hadha, Acaa2, and Acadvl mRNA expression in K562 cells. quinone 14-20 hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha Homo sapiens 92-97 32478940-6 2020 We found that 1,4-BQ significantly decreased LC levels and downregulated Cpt1a, Cpt2, Crat, Hadha, Acaa2, and Acadvl mRNA expression in K562 cells. quinone 14-20 acetyl-CoA acyltransferase 2 Homo sapiens 99-104 32974194-5 2020 Studies have shown that NQO1 can bioactivate certain quinone molecules (e.g., ortho-naphthoquinone and beta-lapachone) to induce a futile redox cycle leading to the formation of oxidative DNA damage, hyperactivation of poly(ADP-ribose) polymerase 1 (PARP1), and catastrophic depletion of NAD+ and ATP, which culminates in cellular lethality via NAD+-Keresis. quinone 53-60 NAD(P)H quinone dehydrogenase 1 Homo sapiens 24-28 32974194-5 2020 Studies have shown that NQO1 can bioactivate certain quinone molecules (e.g., ortho-naphthoquinone and beta-lapachone) to induce a futile redox cycle leading to the formation of oxidative DNA damage, hyperactivation of poly(ADP-ribose) polymerase 1 (PARP1), and catastrophic depletion of NAD+ and ATP, which culminates in cellular lethality via NAD+-Keresis. quinone 53-60 poly(ADP-ribose) polymerase 1 Homo sapiens 219-248 32974194-5 2020 Studies have shown that NQO1 can bioactivate certain quinone molecules (e.g., ortho-naphthoquinone and beta-lapachone) to induce a futile redox cycle leading to the formation of oxidative DNA damage, hyperactivation of poly(ADP-ribose) polymerase 1 (PARP1), and catastrophic depletion of NAD+ and ATP, which culminates in cellular lethality via NAD+-Keresis. quinone 53-60 poly(ADP-ribose) polymerase 1 Homo sapiens 250-255 33045951-4 2020 A detailed kinetic mechanism has now been developed for the diaphorase (NADH-dehydrogenase) reaction catalyzed by pig heart LADH using 2,6-dichlorophenol-indophenol (DCPIP) as a model quinone electron acceptor. quinone 184-191 dihydrolipoamide dehydrogenase Sus scrofa 124-128 32799638-7 2021 Our results provide the bases for a rational modification of new molecules based in quinone scaffold, in order to design more potent Hsp90 inhibitors, which would exhibit highly potent antitumor activity. quinone 84-91 heat shock protein 90 alpha family class A member 1 Homo sapiens 133-138 32678225-2 2020 We compared background levels of naphthalene and estrogen quinone-derived adducts in serum albumin (Alb) from 143 women with breast cancer and 119 healthy controls. quinone 58-65 albumin Homo sapiens 91-98 32678225-2 2020 We compared background levels of naphthalene and estrogen quinone-derived adducts in serum albumin (Alb) from 143 women with breast cancer and 119 healthy controls. quinone 58-65 albumin Homo sapiens 100-103 32538077-5 2020 Upon removal of the galactosyl group in MUGF by beta-galactosidase labeling of the target cell surface proteins, the resulting product containing the quinone methide group was found to be both cell-membrane-permeable and reactive with intracellular nucleophiles, thereby providing fluorescent adducts. quinone 150-157 galactosidase beta 1 Homo sapiens 48-66 32561586-7 2020 These results provide an explanation for the origin of the benzoquinone ring, 4-hydroxybenzoate, and suggest that Aro10p has benzoylformate and 4-hydroxybenzoylformate decarboxylase functions in yeast.IMPORTANCE We present here evidence of the existence of the mandelate pathway in yeast for the synthesis of benzenoids. quinone 59-71 aro10p None 114-120 32760361-0 2020 Corrigendum: All Three Endogenous Quinone Species of Escherichia coli Are Involved in Controlling the Activity of the Aerobic/Anaerobic Response Regulator ArcA. quinone 34-41 arginine deiminase Escherichia coli 155-159 32606871-0 2020 Protective Effect of Benzoquinone Isolated from the Roots of Averrhoa carambola L. on Streptozotocin-Induced Diabetic Mice by Inhibiting the TLR4/NF-kappaB Signaling Pathway. quinone 21-33 toll-like receptor 4 Mus musculus 141-145 32406673-4 2020 Herein, a series of small-molecule quinone derivatives (SMQD) as cathode materials for AIB was investigated. quinone 35-42 ANIB1 Homo sapiens 87-90 32456290-8 2020 It is also known that bioactivation of CAPE to its corresponding quinone metabolite by tyrosinase would lead to GST inhibition and selective melanoma cell death. quinone 65-72 glutathione S-transferase kappa 1 Homo sapiens 112-115 32606871-0 2020 Protective Effect of Benzoquinone Isolated from the Roots of Averrhoa carambola L. on Streptozotocin-Induced Diabetic Mice by Inhibiting the TLR4/NF-kappaB Signaling Pathway. quinone 21-33 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 146-155 32626511-9 2020 CYP1B1 overexpression results in the conversion of estrogens to quinone forms, which bind with DNA and create a predisposition for cancer in several organs, such as the brain, breast, and ovary. quinone 64-71 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-6 32371483-0 2020 Neutron crystallography of copper amine oxidase reveals keto/enolate interconversion of the quinone cofactor and unusual proton sharing. quinone 92-99 amine oxidase copper containing 3 Homo sapiens 27-47 32371867-5 2020 We show that quinone-enriched samples exhibit high selectivity and activity with a H2O2 yield ratio of up to 97.8 % at 0.75 V vs. RHE. quinone 13-20 factor interacting with PAPOLA and CPSF1 Homo sapiens 130-133 32182040-2 2020 Indeed, VKORC1 catalyzes reduction of vitamin K epoxide to quinone and then to hydroquinone. quinone 59-66 vitamin K epoxide reductase complex subunit 1 Homo sapiens 8-14 32184040-6 2020 Outside of this compound, the other synthesized compounds, which could avoid the generation of a reactive quinone-methide intermediate, inhibited CYP3A4 equal to or stronger than NVP. quinone 106-113 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 146-152 31935363-8 2020 Benzoquinone derivatives act as ROS-scavenging molecules, which modulated the TLR4-CD14 signaling pathway to inhibit the expression of procaspase-1 and IL-1beta in cells, induced apoptosis via a mitochondrial pathway by upregulating the ratio of Bax/Bcl-2 and by activating caspase-3, as well as inhibited the expression of the anti-apoptotic proteins FLIP and XIAP in activated LX-2 cells. quinone 0-12 toll like receptor 4 Homo sapiens 78-82 31814180-2 2020 Its unique catalytic mechanism involving the two-electron reduction of quinone-based compounds has made it a useful target to exploit in the design of hNQO1 fluorescent chemosensors and hNQO1-activatable-prodrugs. quinone 71-78 NAD(P)H quinone dehydrogenase 1 Homo sapiens 151-156 31814180-2 2020 Its unique catalytic mechanism involving the two-electron reduction of quinone-based compounds has made it a useful target to exploit in the design of hNQO1 fluorescent chemosensors and hNQO1-activatable-prodrugs. quinone 71-78 NAD(P)H quinone dehydrogenase 1 Homo sapiens 186-191 32003394-1 2020 Reported herein is a practical route to access synthetically challenging and chemoselective alpha,alpha"-diarylmethyl N-glycosides via Sc(OTf)3-catalyzed 1,6-conjugate addition of amino sugars with para-quinone methides (p-QMs). quinone 198-210 POU class 5 homeobox 1 Homo sapiens 135-143 31935363-8 2020 Benzoquinone derivatives act as ROS-scavenging molecules, which modulated the TLR4-CD14 signaling pathway to inhibit the expression of procaspase-1 and IL-1beta in cells, induced apoptosis via a mitochondrial pathway by upregulating the ratio of Bax/Bcl-2 and by activating caspase-3, as well as inhibited the expression of the anti-apoptotic proteins FLIP and XIAP in activated LX-2 cells. quinone 0-12 CD14 molecule Homo sapiens 83-87 31935363-8 2020 Benzoquinone derivatives act as ROS-scavenging molecules, which modulated the TLR4-CD14 signaling pathway to inhibit the expression of procaspase-1 and IL-1beta in cells, induced apoptosis via a mitochondrial pathway by upregulating the ratio of Bax/Bcl-2 and by activating caspase-3, as well as inhibited the expression of the anti-apoptotic proteins FLIP and XIAP in activated LX-2 cells. quinone 0-12 interleukin 1 beta Homo sapiens 152-160 31935363-8 2020 Benzoquinone derivatives act as ROS-scavenging molecules, which modulated the TLR4-CD14 signaling pathway to inhibit the expression of procaspase-1 and IL-1beta in cells, induced apoptosis via a mitochondrial pathway by upregulating the ratio of Bax/Bcl-2 and by activating caspase-3, as well as inhibited the expression of the anti-apoptotic proteins FLIP and XIAP in activated LX-2 cells. quinone 0-12 BCL2 associated X, apoptosis regulator Homo sapiens 246-249 31935363-8 2020 Benzoquinone derivatives act as ROS-scavenging molecules, which modulated the TLR4-CD14 signaling pathway to inhibit the expression of procaspase-1 and IL-1beta in cells, induced apoptosis via a mitochondrial pathway by upregulating the ratio of Bax/Bcl-2 and by activating caspase-3, as well as inhibited the expression of the anti-apoptotic proteins FLIP and XIAP in activated LX-2 cells. quinone 0-12 BCL2 apoptosis regulator Homo sapiens 250-255 31935363-8 2020 Benzoquinone derivatives act as ROS-scavenging molecules, which modulated the TLR4-CD14 signaling pathway to inhibit the expression of procaspase-1 and IL-1beta in cells, induced apoptosis via a mitochondrial pathway by upregulating the ratio of Bax/Bcl-2 and by activating caspase-3, as well as inhibited the expression of the anti-apoptotic proteins FLIP and XIAP in activated LX-2 cells. quinone 0-12 caspase 3 Homo sapiens 274-283 31935363-8 2020 Benzoquinone derivatives act as ROS-scavenging molecules, which modulated the TLR4-CD14 signaling pathway to inhibit the expression of procaspase-1 and IL-1beta in cells, induced apoptosis via a mitochondrial pathway by upregulating the ratio of Bax/Bcl-2 and by activating caspase-3, as well as inhibited the expression of the anti-apoptotic proteins FLIP and XIAP in activated LX-2 cells. quinone 0-12 X-linked inhibitor of apoptosis Homo sapiens 361-365 31935363-10 2020 Treatment with benzoquinone derivatives significantly decreased the levels of liver injury markers and lipid peroxidation caused by excessive ROS, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), and malondialdehyde (MDA). quinone 15-27 solute carrier family 17 (anion/sugar transporter), member 5 Mus musculus 157-183 31935363-10 2020 Treatment with benzoquinone derivatives significantly decreased the levels of liver injury markers and lipid peroxidation caused by excessive ROS, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), and malondialdehyde (MDA). quinone 15-27 solute carrier family 17 (anion/sugar transporter), member 5 Mus musculus 185-188 31935363-10 2020 Treatment with benzoquinone derivatives significantly decreased the levels of liver injury markers and lipid peroxidation caused by excessive ROS, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), and malondialdehyde (MDA). quinone 15-27 glutamic pyruvic transaminase, soluble Mus musculus 191-215 31935363-10 2020 Treatment with benzoquinone derivatives significantly decreased the levels of liver injury markers and lipid peroxidation caused by excessive ROS, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), and malondialdehyde (MDA). quinone 15-27 glutamic pyruvic transaminase, soluble Mus musculus 217-220 31935363-11 2020 Moreover, treatment with benzoquinone derivatives significantly inhibited extracellular matrix (ECM) deposition and downregulated the mRNA and protein expression of liver fibrosis markers, such as collagen I, alpha-smooth muscle actin (alpha-SMA), and TIMP-1. quinone 25-37 actin alpha 2, smooth muscle, aorta Mus musculus 209-234 31935363-11 2020 Moreover, treatment with benzoquinone derivatives significantly inhibited extracellular matrix (ECM) deposition and downregulated the mRNA and protein expression of liver fibrosis markers, such as collagen I, alpha-smooth muscle actin (alpha-SMA), and TIMP-1. quinone 25-37 actin alpha 2, smooth muscle, aorta Mus musculus 236-245 31935363-11 2020 Moreover, treatment with benzoquinone derivatives significantly inhibited extracellular matrix (ECM) deposition and downregulated the mRNA and protein expression of liver fibrosis markers, such as collagen I, alpha-smooth muscle actin (alpha-SMA), and TIMP-1. quinone 25-37 tissue inhibitor of metalloproteinase 1 Mus musculus 252-258 32024182-4 2020 The aim of this study is to confirm the relationship between HIF-1alpha and PTP4A3 in benzene toxicity, as well as the function of PTP4A3 on cell toxicity induced by 1,4-benzoquinone (1,4-BQ). quinone 166-182 protein tyrosine phosphatase 4A3 Homo sapiens 131-137 31183610-7 2020 In this sense, mitochondrial functioning of sod1 cells were highly affected by exposure to this quinone. quinone 97-104 superoxide dismutase SOD1 Saccharomyces cerevisiae S288C 44-48 32024182-4 2020 The aim of this study is to confirm the relationship between HIF-1alpha and PTP4A3 in benzene toxicity, as well as the function of PTP4A3 on cell toxicity induced by 1,4-benzoquinone (1,4-BQ). quinone 184-190 protein tyrosine phosphatase 4A3 Homo sapiens 131-137 32024182-6 2020 A cell line with suppressed PTP4A3 was established to investigate the function of PTP4A3 in 1,4-BQ toxicity in vitro. quinone 92-98 protein tyrosine phosphatase 4A3 Homo sapiens 82-88 32024182-7 2020 The results revealed that cell proliferation inhibition was more aggravated in PTP4A3 low-expression cells than in the control cells after 1,4-BQ treatment. quinone 139-145 protein tyrosine phosphatase 4A3 Homo sapiens 79-85 32024182-9 2020 An increase in DNA damage was seen in PTP4A3 down-regulated cells at the 10 muM 1,4-BQ group, whereas the results reversed at the concentration of 20 muM. quinone 80-86 protein tyrosine phosphatase 4A3 Homo sapiens 38-44 32024182-10 2020 Moreover, the apoptosis rate increased higher in down-regulated PTP4A3 cells after 1,4-BQ exposure. quinone 83-89 protein tyrosine phosphatase 4A3 Homo sapiens 64-70 32024182-11 2020 In addition, PI3K/AKT pathway was significantly restrained in cells with inhibited PTP4A3 after 1,4-BQ treatment. quinone 96-102 AKT serine/threonine kinase 1 Homo sapiens 18-21 32024182-11 2020 In addition, PI3K/AKT pathway was significantly restrained in cells with inhibited PTP4A3 after 1,4-BQ treatment. quinone 96-102 protein tyrosine phosphatase 4A3 Homo sapiens 83-89 32024182-13 2020 Inhibition of PTP4A3 could aggravate cell proliferation suppression and apoptosis by regulating PI3K/AKT pathway after 1,4-BQ treatment. quinone 119-125 protein tyrosine phosphatase 4A3 Homo sapiens 14-20 32024182-13 2020 Inhibition of PTP4A3 could aggravate cell proliferation suppression and apoptosis by regulating PI3K/AKT pathway after 1,4-BQ treatment. quinone 119-125 AKT serine/threonine kinase 1 Homo sapiens 101-104 31926625-0 2020 Modification of Cys residues in human thioredoxin-1 by p-benzoquinone causes inhibition of its catalytic activity and activation of the ASK1/p38-MAPK signalling pathway. quinone 57-69 mitogen-activated protein kinase 14 Homo sapiens 141-144 31830176-0 2020 Quaternary beta2,2-amino acid derivatives by asymmetric addition of isoxazolidin-5-ones to para-quinone methides. quinone 91-103 ATPase H+ transporting V0 subunit a2 Homo sapiens 11-16 31830176-1 2020 The highly enantioselective (>99.5% ee) synthesis of a new class of densely functionalized beta2,2-amino acid derivatives by reacting isoxazolidin-5-ones with para-quinone methides in the presence of chiral ammonium salt phase-transfer catalysts was developed. quinone 159-171 ATPase H+ transporting V0 subunit a2 Homo sapiens 91-96 31524622-5 2020 Inspiringly, p-benzoquinone (p-BQ) as a trapping agent in most advanced oxidation process could be turned into the positive one in the NaBO2/PMS system, achieving a nearly 3-times enhancement in terms of the rate constant for AR1 removal. quinone 13-27 transcription factor 20 Homo sapiens 226-229 31524622-5 2020 Inspiringly, p-benzoquinone (p-BQ) as a trapping agent in most advanced oxidation process could be turned into the positive one in the NaBO2/PMS system, achieving a nearly 3-times enhancement in terms of the rate constant for AR1 removal. quinone 29-33 transcription factor 20 Homo sapiens 226-229 31926625-0 2020 Modification of Cys residues in human thioredoxin-1 by p-benzoquinone causes inhibition of its catalytic activity and activation of the ASK1/p38-MAPK signalling pathway. quinone 57-69 thioredoxin Homo sapiens 38-51 31880924-4 2020 Catalysis of both NADH oxidation and lipophilic quinone reduction by membrane-bound NDH-2 followed the Michaelis-Menten model; however, the maximum turnover was only achieved when a high concentration of quinone (>3 mM) was present in the membrane, suggesting that quinone availability regulates NADH-coupled respiration activity. quinone 48-55 DExH-box helicase 9 Homo sapiens 84-89 31880924-4 2020 Catalysis of both NADH oxidation and lipophilic quinone reduction by membrane-bound NDH-2 followed the Michaelis-Menten model; however, the maximum turnover was only achieved when a high concentration of quinone (>3 mM) was present in the membrane, suggesting that quinone availability regulates NADH-coupled respiration activity. quinone 204-211 DExH-box helicase 9 Homo sapiens 84-89 31880924-4 2020 Catalysis of both NADH oxidation and lipophilic quinone reduction by membrane-bound NDH-2 followed the Michaelis-Menten model; however, the maximum turnover was only achieved when a high concentration of quinone (>3 mM) was present in the membrane, suggesting that quinone availability regulates NADH-coupled respiration activity. quinone 204-211 DExH-box helicase 9 Homo sapiens 84-89 31880924-5 2020 The quinone analogue 2-heptyl-4-hydroxyquinoline-N-oxide inhibited C. thermarum NDH-2 activity, and its potency is higher in a membrane environment compared to assays performed with water-soluble quinone analogues, demonstrating the importance of testing compounds under physiologically relevant conditions. quinone 4-11 DExH-box helicase 9 Homo sapiens 80-85 31919413-0 2020 GSK3beta is a key regulator of the ROS-dependent necrotic death induced by the quinone DMNQ. quinone 79-86 glycogen synthase kinase 3 alpha Homo sapiens 0-8 31919413-6 2020 Using the quinone DMNQ, a ROS generator, we demonstrate that GSK3beta is involved in the regulation of ROS-dependent necrosis. quinone 10-17 glycogen synthase kinase 3 alpha Homo sapiens 61-69 31919413-9 2020 During the quinone-induced pro-necrotic stress, GSK3beta gradually accumulates into the nucleus, before the collapse of the mitochondrial membrane potential. quinone 11-18 glycogen synthase kinase 3 alpha Homo sapiens 48-56 31919413-13 2020 In summary, GSK3beta by blunting the anti-oxidant response and particularly NQO1 and NQO2 expression, favors the appearance of necrosis in response to ROS, as generated by the quinone DMNQ. quinone 176-183 glycogen synthase kinase 3 alpha Homo sapiens 12-20 32475856-6 2020 To develop lysosome-localized hHEXA-specific fluorogenic substrates based on the difference in their active site structures, our developed quinone methide cleavage substrate design platform was applied for the molecular design of substrates. quinone 139-146 hexosaminidase subunit alpha Homo sapiens 30-35 31590044-0 2020 Inhibition and crosslinking of the selenoprotein thioredoxin reductase-1 by p-benzoquinone. quinone 76-90 selenoprotein F Mus musculus 35-48 31590044-0 2020 Inhibition and crosslinking of the selenoprotein thioredoxin reductase-1 by p-benzoquinone. quinone 76-90 thioredoxin reductase 1 Mus musculus 49-72 31590044-5 2020 Here, we report data on the interaction of p-benzoquinone (BQ) with the selenoprotein thioredoxin reductase-1 (TrxR1), which exposes an accessible Sec residue upon physiological reduction by NADPH. quinone 43-57 thioredoxin reductase 1 Mus musculus 111-116 31590044-5 2020 Here, we report data on the interaction of p-benzoquinone (BQ) with the selenoprotein thioredoxin reductase-1 (TrxR1), which exposes an accessible Sec residue upon physiological reduction by NADPH. quinone 43-57 eukaryotic elongation factor, selenocysteine-tRNA-specific Mus musculus 147-150 31590044-5 2020 Here, we report data on the interaction of p-benzoquinone (BQ) with the selenoprotein thioredoxin reductase-1 (TrxR1), which exposes an accessible Sec residue upon physiological reduction by NADPH. quinone 43-57 2,4-dienoyl CoA reductase 1, mitochondrial Mus musculus 191-196 31590044-5 2020 Here, we report data on the interaction of p-benzoquinone (BQ) with the selenoprotein thioredoxin reductase-1 (TrxR1), which exposes an accessible Sec residue upon physiological reduction by NADPH. quinone 59-61 thioredoxin reductase 1 Mus musculus 111-116 31590044-5 2020 Here, we report data on the interaction of p-benzoquinone (BQ) with the selenoprotein thioredoxin reductase-1 (TrxR1), which exposes an accessible Sec residue upon physiological reduction by NADPH. quinone 59-61 eukaryotic elongation factor, selenocysteine-tRNA-specific Mus musculus 147-150 31590044-5 2020 Here, we report data on the interaction of p-benzoquinone (BQ) with the selenoprotein thioredoxin reductase-1 (TrxR1), which exposes an accessible Sec residue upon physiological reduction by NADPH. quinone 59-61 2,4-dienoyl CoA reductase 1, mitochondrial Mus musculus 191-196 31590044-6 2020 Our results reveal that BQ targets NADPH-reduced TrxR1 and inhibits its activity using 5,5"-dithiobis(2-nitrobenzoic acid) or juglone as model substrates, consistent with the targeting of both the Cys and Sec residues of TrxR1. quinone 24-26 2,4-dienoyl CoA reductase 1, mitochondrial Mus musculus 35-40 31590044-6 2020 Our results reveal that BQ targets NADPH-reduced TrxR1 and inhibits its activity using 5,5"-dithiobis(2-nitrobenzoic acid) or juglone as model substrates, consistent with the targeting of both the Cys and Sec residues of TrxR1. quinone 24-26 thioredoxin reductase 1 Mus musculus 49-54 31590044-6 2020 Our results reveal that BQ targets NADPH-reduced TrxR1 and inhibits its activity using 5,5"-dithiobis(2-nitrobenzoic acid) or juglone as model substrates, consistent with the targeting of both the Cys and Sec residues of TrxR1. quinone 24-26 eukaryotic elongation factor, selenocysteine-tRNA-specific Mus musculus 205-208 31590044-6 2020 Our results reveal that BQ targets NADPH-reduced TrxR1 and inhibits its activity using 5,5"-dithiobis(2-nitrobenzoic acid) or juglone as model substrates, consistent with the targeting of both the Cys and Sec residues of TrxR1. quinone 24-26 thioredoxin reductase 1 Mus musculus 221-226 31590044-9 2020 Addition of NADPH after BQ pre-treatment could resolve the disulfide-linked crosslinking. quinone 24-26 2,4-dienoyl CoA reductase 1, mitochondrial Mus musculus 12-17 31590044-12 2020 We suggest that TrxR1 targeting can explain some of the cytotoxicity of BQ, and potentially also that of other quinone compounds. quinone 72-74 thioredoxin reductase 1 Mus musculus 16-21 31590044-12 2020 We suggest that TrxR1 targeting can explain some of the cytotoxicity of BQ, and potentially also that of other quinone compounds. quinone 111-118 thioredoxin reductase 1 Mus musculus 16-21 31926625-0 2020 Modification of Cys residues in human thioredoxin-1 by p-benzoquinone causes inhibition of its catalytic activity and activation of the ASK1/p38-MAPK signalling pathway. quinone 57-69 mitogen-activated protein kinase kinase kinase 5 Homo sapiens 136-140 31926625-3 2020 In the studies reported here, the interactions of a prototypic quinone compound, p-benzoquinone (BQ), with the key redox protein, thioredoxin-1 (Trx1) were examined. quinone 81-95 thioredoxin Homo sapiens 130-143 31926625-3 2020 In the studies reported here, the interactions of a prototypic quinone compound, p-benzoquinone (BQ), with the key redox protein, thioredoxin-1 (Trx1) were examined. quinone 81-95 thioredoxin Homo sapiens 145-149 31926625-3 2020 In the studies reported here, the interactions of a prototypic quinone compound, p-benzoquinone (BQ), with the key redox protein, thioredoxin-1 (Trx1) were examined. quinone 97-99 thioredoxin Homo sapiens 130-143 31926625-3 2020 In the studies reported here, the interactions of a prototypic quinone compound, p-benzoquinone (BQ), with the key redox protein, thioredoxin-1 (Trx1) were examined. quinone 97-99 thioredoxin Homo sapiens 145-149 31926625-4 2020 BQ binds covalently with isolated Trx1 forming quinoprotein adducts, resulting in a concentration-dependent loss of enzyme activity and crosslink formation. quinone 0-2 thioredoxin Homo sapiens 34-38 31926625-5 2020 Mass spectrometry peptide mass mapping data indicate that BQ forms adducts with all of the Trx1 Cys residues. quinone 58-60 thioredoxin Homo sapiens 91-95 31926625-7 2020 Exposure of macrophage-like (J774A.1) cells to BQ results in a dose-dependent loss of Trx and thioredoxin reductase (TrxR) activities, quinoprotein formation, and a decrease in GSH levels without a concomitant increase in oxidized glutathione. quinone 47-49 thioredoxin 1 Mus musculus 86-89 31926625-7 2020 Exposure of macrophage-like (J774A.1) cells to BQ results in a dose-dependent loss of Trx and thioredoxin reductase (TrxR) activities, quinoprotein formation, and a decrease in GSH levels without a concomitant increase in oxidized glutathione. quinone 47-49 peroxiredoxin 2 Mus musculus 94-115 31926625-7 2020 Exposure of macrophage-like (J774A.1) cells to BQ results in a dose-dependent loss of Trx and thioredoxin reductase (TrxR) activities, quinoprotein formation, and a decrease in GSH levels without a concomitant increase in oxidized glutathione. quinone 47-49 peroxiredoxin 2 Mus musculus 117-121 31926625-10 2020 Reaction of BQ with Trx in cells resulted in the activation of apoptosis signal-regulating kinase 1 (ASK1), and p38 mitogen-activated protein kinase (MAPK) leading to apoptotic cell death. quinone 12-14 thioredoxin Homo sapiens 20-23 31926625-10 2020 Reaction of BQ with Trx in cells resulted in the activation of apoptosis signal-regulating kinase 1 (ASK1), and p38 mitogen-activated protein kinase (MAPK) leading to apoptotic cell death. quinone 12-14 mitogen-activated protein kinase kinase kinase 5 Homo sapiens 63-99 31926625-10 2020 Reaction of BQ with Trx in cells resulted in the activation of apoptosis signal-regulating kinase 1 (ASK1), and p38 mitogen-activated protein kinase (MAPK) leading to apoptotic cell death. quinone 12-14 mitogen-activated protein kinase kinase kinase 5 Homo sapiens 101-105 31926625-10 2020 Reaction of BQ with Trx in cells resulted in the activation of apoptosis signal-regulating kinase 1 (ASK1), and p38 mitogen-activated protein kinase (MAPK) leading to apoptotic cell death. quinone 12-14 mitogen-activated protein kinase 14 Homo sapiens 112-148 31926625-11 2020 These data suggest that BQ reacts covalently with Cys residues in Trx, including at the active site, leading to enzyme inactivation and protein cross-linking. quinone 24-26 thioredoxin Homo sapiens 66-69 31673948-2 2019 The results of this study demonstrate that for detecting nitramine-class explosives, such as 1,3,5-trinitroperhydro-1,3,5-triazine (RDX) and 1,3,5,7-tetranitro-1,3,5,7-tetrazacyclooctane (HMX), 1,4-benzoquinone (BQ) is a highly effective and efficient dopant. quinone 194-210 radixin Homo sapiens 132-135 31541949-8 2019 In addition, we found that the knockdown of lncRNAVNN3 reduced phosphorylation of beclin1 and Bcl-2, which mediated 1, 4-benzoquinone-induced autophagy and apoptosis. quinone 119-133 beclin 1 Homo sapiens 82-89 31541949-8 2019 In addition, we found that the knockdown of lncRNAVNN3 reduced phosphorylation of beclin1 and Bcl-2, which mediated 1, 4-benzoquinone-induced autophagy and apoptosis. quinone 119-133 BCL2 apoptosis regulator Homo sapiens 94-99 31541949-9 2019 Overall, lncRNAVNN3 mediated 1, 4-benzoquinone-induced autophagy and apoptosis though regulating phosphorylation of beclin1 and Bcl-2, suggesting that lncRNAVNN3 might be a novel early sensitive biomarker of benzene-induced hematotoxicity. quinone 32-46 beclin 1 Homo sapiens 116-123 31541949-9 2019 Overall, lncRNAVNN3 mediated 1, 4-benzoquinone-induced autophagy and apoptosis though regulating phosphorylation of beclin1 and Bcl-2, suggesting that lncRNAVNN3 might be a novel early sensitive biomarker of benzene-induced hematotoxicity. quinone 32-46 BCL2 apoptosis regulator Homo sapiens 128-133 31673948-2 2019 The results of this study demonstrate that for detecting nitramine-class explosives, such as 1,3,5-trinitroperhydro-1,3,5-triazine (RDX) and 1,3,5,7-tetranitro-1,3,5,7-tetrazacyclooctane (HMX), 1,4-benzoquinone (BQ) is a highly effective and efficient dopant. quinone 212-214 radixin Homo sapiens 132-135 31673948-3 2019 When used in conjunction with ambient-pressure negative-ion helium-plasma ionization (HePI), 1,4-benzoquinone readily captures an electron, forming an abundant molecular anion (m/z 108), which upon exposure to vapors of RDX and HMX generates adduct ions of m/z 330 and 404, respectively. quinone 93-109 radixin Homo sapiens 220-223 31673948-4 2019 The signal level recorded for RDX upon adduction to the radical anion of 1,4-benzoquinone under our experimental conditions was significantly higher than that realized by chloride adduction using dichloromethane (DCM) as the dopant. quinone 73-89 radixin Homo sapiens 30-33 30865484-0 2019 Cytotoxicity of safrole in HepaRG cells: studies on the role of CYP1A2-mediated ortho-quinone metabolic activation. quinone 86-93 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 64-70 31514018-1 2019 (NRH):quinone oxidoreductase 2 (NQO2) is associated with various processes involved in cancer initiation and progression probably via the production of ROS during quinone metabolism. quinone 6-13 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 32-36 30865484-15 2019 Collectively, these data suggest that the ortho-quinone RM may mediate safrole hepatotoxicity, and CYP1A2 was the core enzyme in ortho-quinone RMs-mediated safrole hepatotoxicity. quinone 135-142 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 99-105 31340051-5 2019 Using cultured murine CD-1 fetal liver cells, this study shows that Topo IIalpha activity decreases following 24 hours of exposure to BQ (12.5 and 15.625 microM), with the 12.5 microM confirmed to disrupt the c-kit+Lin-Sca-1-Il7ralpha- population of cells in culture. quinone 134-136 KIT proto-oncogene receptor tyrosine kinase Mus musculus 209-214 31601785-4 2019 Results showed that benzene metabolite (1, 4-benzoquinone, 1, 4-BQ) dose-dependently induced autophagy and apoptosis via enhancing phosphorylation of Bcl-2 and beclin1. quinone 40-57 BCL2 apoptosis regulator Homo sapiens 150-155 31601785-4 2019 Results showed that benzene metabolite (1, 4-benzoquinone, 1, 4-BQ) dose-dependently induced autophagy and apoptosis via enhancing phosphorylation of Bcl-2 and beclin1. quinone 40-57 beclin 1 Homo sapiens 160-167 31322268-3 2019 beta-Lapachone (beta-Lap), a natural quinone compound, has been developed for cancer treatment due to its strong cytotoxic effect through its action on NAD(P)H:quinone oxidoreductase 1 (NQO1)-dependent activity. quinone 37-44 NAD(P)H quinone dehydrogenase 1 Homo sapiens 152-184 31248982-0 2019 Benzoquinone, a leukemogenic metabolite of benzene, catalytically inhibits the protein tyrosine phosphatase PTPN2 and alters STAT1 signaling. quinone 0-12 protein tyrosine phosphatase non-receptor type 2 Homo sapiens 108-113 31248982-0 2019 Benzoquinone, a leukemogenic metabolite of benzene, catalytically inhibits the protein tyrosine phosphatase PTPN2 and alters STAT1 signaling. quinone 0-12 signal transducer and activator of transcription 1 Homo sapiens 125-130 31248982-7 2019 We show here that 1,4-benzoquinone directly impairs PTPN2 activity. quinone 18-34 protein tyrosine phosphatase non-receptor type 2 Homo sapiens 52-57 31248982-8 2019 Mechanistic and kinetic experiments with purified human PTPN2 indicated that this impairment results from the irreversible formation (k inact = 645 m-1 s-1) of a covalent 1,4-benzoquinone adduct at the catalytic cysteine residue of the enzyme. quinone 171-187 protein tyrosine phosphatase non-receptor type 2 Homo sapiens 56-61 31248982-9 2019 Accordingly, cell experiments revealed that 1,4-benzoquinone exposure irreversibly inhibits cellular PTPN2 and concomitantly increases tyrosine phosphorylation of STAT1 and expression of STAT1-regulated genes. quinone 44-60 protein tyrosine phosphatase non-receptor type 2 Homo sapiens 101-106 31248982-9 2019 Accordingly, cell experiments revealed that 1,4-benzoquinone exposure irreversibly inhibits cellular PTPN2 and concomitantly increases tyrosine phosphorylation of STAT1 and expression of STAT1-regulated genes. quinone 44-60 signal transducer and activator of transcription 1 Homo sapiens 163-168 31248982-9 2019 Accordingly, cell experiments revealed that 1,4-benzoquinone exposure irreversibly inhibits cellular PTPN2 and concomitantly increases tyrosine phosphorylation of STAT1 and expression of STAT1-regulated genes. quinone 44-60 signal transducer and activator of transcription 1 Homo sapiens 187-192 31480790-13 2019 NQO1 overexpression increases cell sensitivity to beta-lapachone whereas NQO1*2 polymorphism triggers quinone-based chemotherapies-sensitivity. quinone 102-109 NAD(P)H quinone dehydrogenase 1 Homo sapiens 73-77 31480790-15 2019 We suggest that determining NQO1 polymorphism may be important when considering the use of quinone-based chemotherapeutic drugs. quinone 91-98 NAD(P)H quinone dehydrogenase 1 Homo sapiens 28-32 31339696-3 2019 It was found that, in human melanoma A375 cells, 3,4-DHB is easily converted to its ortho-quinone via copper-containing tyrosinase-mediated two-electron oxidation along with generation of reactive oxygen species (ROS) derived from the oxidation; the resulting ortho-quinone and ROS are responsible for its ability to sensitize the cisplatin-resistant cells by inhibiting GST, followed by induction of apoptosis in an ASK1-JNK/p38 signaling cascade and mitochondria-dependent pathway. quinone 90-97 tyrosinase Homo sapiens 120-130 31339696-3 2019 It was found that, in human melanoma A375 cells, 3,4-DHB is easily converted to its ortho-quinone via copper-containing tyrosinase-mediated two-electron oxidation along with generation of reactive oxygen species (ROS) derived from the oxidation; the resulting ortho-quinone and ROS are responsible for its ability to sensitize the cisplatin-resistant cells by inhibiting GST, followed by induction of apoptosis in an ASK1-JNK/p38 signaling cascade and mitochondria-dependent pathway. quinone 266-273 tyrosinase Homo sapiens 120-130 31381583-7 2019 The in vitro study validated the aberrant hypermethylation of hMLH1 after treatment with BQ. quinone 89-91 mutL homolog 1 Homo sapiens 62-67 31340051-5 2019 Using cultured murine CD-1 fetal liver cells, this study shows that Topo IIalpha activity decreases following 24 hours of exposure to BQ (12.5 and 15.625 microM), with the 12.5 microM confirmed to disrupt the c-kit+Lin-Sca-1-Il7ralpha- population of cells in culture. quinone 134-136 ataxin 1 Mus musculus 219-224 31340051-5 2019 Using cultured murine CD-1 fetal liver cells, this study shows that Topo IIalpha activity decreases following 24 hours of exposure to BQ (12.5 and 15.625 microM), with the 12.5 microM confirmed to disrupt the c-kit+Lin-Sca-1-Il7ralpha- population of cells in culture. quinone 134-136 interleukin 7 receptor Mus musculus 225-234 31244153-1 2019 Formation of quinone methides (QMs) by photoelimination of an ammonium salt from cresol derivatives was investigated by femtosecond transient absorption spectroscopy (fs-TA) and computationally by time-dependent density functional theory using the PCM(water)/(TD-)B3LYP/6-311++G(d,p) level of theory. quinone 13-20 protein tyrosine phosphatase non-receptor type 22 Homo sapiens 266-269 31140795-4 2019 Switching ligands to (+-)-CF3-SOX with the use of a less bulky quinone oxidant, the kinetic syn-1,3 amino alcohol motif can be accessed in comparable yields and selectivities. quinone 63-70 synapsin I Homo sapiens 92-97 31094530-0 2019 Visible-Light-Triggered Cyanoalkylation of para-Quinone Methides and Its Application to the Synthesis of GPR40 Agonists. quinone 43-55 free fatty acid receptor 1 Homo sapiens 105-110 30954926-5 2019 This fabricated nonenzymatic nanoprobe1 (NP1) can be applied for recognizing the cTnI specifically and amplifying the current signal by catalyzing the oxidation of hydroquinone (HQ) to benzoquinone (BQ) with H2O2. quinone 185-197 troponin I3, cardiac type Homo sapiens 81-85 30954926-5 2019 This fabricated nonenzymatic nanoprobe1 (NP1) can be applied for recognizing the cTnI specifically and amplifying the current signal by catalyzing the oxidation of hydroquinone (HQ) to benzoquinone (BQ) with H2O2. quinone 199-201 troponin I3, cardiac type Homo sapiens 81-85 31026584-6 2019 p-Benzoquinone (BQ) induced dimerization of GAPDH and CK (but not BSA, HSA, or papain) in a dose- and time-dependent manner. quinone 0-14 LOC786101 Bos taurus 44-49 31026584-6 2019 p-Benzoquinone (BQ) induced dimerization of GAPDH and CK (but not BSA, HSA, or papain) in a dose- and time-dependent manner. quinone 16-18 LOC786101 Bos taurus 44-49 31141977-2 2019 Although a higher PPO dose was required for quinone oxidation of branched alkylphenols, they were completely or mostly removed by quinone adsorption on chitosan beads or powders. quinone 44-51 protoporphyrinogen oxidase Homo sapiens 18-21 30995391-1 2019 NAD(P)H:quinone oxidoreductase 1 (NQO1) is a key enzyme providing cytoprotection from quinone species. quinone 8-15 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 31141977-2 2019 Although a higher PPO dose was required for quinone oxidation of branched alkylphenols, they were completely or mostly removed by quinone adsorption on chitosan beads or powders. quinone 130-137 protoporphyrinogen oxidase Homo sapiens 18-21 31141977-3 2019 The apparent activity of PPO increased by a decrease in quinone concentration. quinone 56-63 protoporphyrinogen oxidase Homo sapiens 25-28 31141977-4 2019 On the other hand, in the homogeneous systems with solutions of chitosan and PPO at pH 6.0, longer reaction times were required to generate insoluble aggregates, and a small amount of quinone derivatives were left in the solution even under optimum conditions. quinone 184-191 protoporphyrinogen oxidase Homo sapiens 77-80 31141977-5 2019 These results support that the two-step reaction, that is, PPO-catalyzed quinone oxidation and subsequent quinone adsorption on chitosan beads or powders, in the heterogeneous system is a good procedure for removing linear and branched alkylphenols from aqueous medium. quinone 73-80 protoporphyrinogen oxidase Homo sapiens 59-62 31141977-5 2019 These results support that the two-step reaction, that is, PPO-catalyzed quinone oxidation and subsequent quinone adsorption on chitosan beads or powders, in the heterogeneous system is a good procedure for removing linear and branched alkylphenols from aqueous medium. quinone 106-113 protoporphyrinogen oxidase Homo sapiens 59-62 30916930-2 2019 Herein, we develop a novel portable and recyclable surface-enhanced Raman scattering (SERS) sensor, prepared by assembling gold nanoparticles and p-thiol catechol ( p-TC) on an ITO electrode, for detecting TYR activity via the SERS spectral variation caused by the conversion of p-TC into its corresponding quinone under TYR catalysis. quinone 307-314 tyrosinase Homo sapiens 206-209 30789743-8 2019 The measured quinone redox potentials of MK-1 and MK-1(H2) differed between organic solvents (presumably due to differences in dielectric constants), and remarkably, an ~20 mV semiquinone redox potential difference was observed between MK-1 and MK-1(H2) in pyridine, acetonitrile, and dimethyl sulfoxide, demonstrating that the degree of saturation in the isoprenyl side chain of MK-1 influences the quinone redox potential. quinone 13-20 potassium voltage-gated channel, shaker-related subfamily, member 1 Mus musculus 41-45 30592774-4 2019 This quinone methide phenylaminecyclopropane prodrug releases the LSD1 inhibitor 2-phenylcyclopropylamine with the glutathione scavenger para-quinone methide to trigger apoptosis in GBM cells. quinone 5-12 lysine demethylase 1A Homo sapiens 66-70 30592774-4 2019 This quinone methide phenylaminecyclopropane prodrug releases the LSD1 inhibitor 2-phenylcyclopropylamine with the glutathione scavenger para-quinone methide to trigger apoptosis in GBM cells. quinone 137-149 lysine demethylase 1A Homo sapiens 66-70 30665033-6 2019 In addition, we evaluated lysozyme modifications induced by 1,4-benzoquinone in concentration-, pH-, temperature-, and time-dependent studies. quinone 60-76 lysozyme Homo sapiens 26-34 30665033-8 2019 Electrochemical properties of selected BQs were monitored using cyclic voltammetry in phosphate buffered aqueous solution, and it was found that quinone reduction potentials correlate well with their reactivity trend toward lysozyme. quinone 145-152 lysozyme Homo sapiens 224-232 30789743-8 2019 The measured quinone redox potentials of MK-1 and MK-1(H2) differed between organic solvents (presumably due to differences in dielectric constants), and remarkably, an ~20 mV semiquinone redox potential difference was observed between MK-1 and MK-1(H2) in pyridine, acetonitrile, and dimethyl sulfoxide, demonstrating that the degree of saturation in the isoprenyl side chain of MK-1 influences the quinone redox potential. quinone 180-187 potassium voltage-gated channel, shaker-related subfamily, member 1 Mus musculus 41-45 30789743-8 2019 The measured quinone redox potentials of MK-1 and MK-1(H2) differed between organic solvents (presumably due to differences in dielectric constants), and remarkably, an ~20 mV semiquinone redox potential difference was observed between MK-1 and MK-1(H2) in pyridine, acetonitrile, and dimethyl sulfoxide, demonstrating that the degree of saturation in the isoprenyl side chain of MK-1 influences the quinone redox potential. quinone 180-187 potassium voltage-gated channel, shaker-related subfamily, member 1 Mus musculus 50-54 30789743-8 2019 The measured quinone redox potentials of MK-1 and MK-1(H2) differed between organic solvents (presumably due to differences in dielectric constants), and remarkably, an ~20 mV semiquinone redox potential difference was observed between MK-1 and MK-1(H2) in pyridine, acetonitrile, and dimethyl sulfoxide, demonstrating that the degree of saturation in the isoprenyl side chain of MK-1 influences the quinone redox potential. quinone 180-187 potassium voltage-gated channel, shaker-related subfamily, member 1 Mus musculus 50-54 30789743-8 2019 The measured quinone redox potentials of MK-1 and MK-1(H2) differed between organic solvents (presumably due to differences in dielectric constants), and remarkably, an ~20 mV semiquinone redox potential difference was observed between MK-1 and MK-1(H2) in pyridine, acetonitrile, and dimethyl sulfoxide, demonstrating that the degree of saturation in the isoprenyl side chain of MK-1 influences the quinone redox potential. quinone 180-187 potassium voltage-gated channel, shaker-related subfamily, member 1 Mus musculus 50-54 30789743-8 2019 The measured quinone redox potentials of MK-1 and MK-1(H2) differed between organic solvents (presumably due to differences in dielectric constants), and remarkably, an ~20 mV semiquinone redox potential difference was observed between MK-1 and MK-1(H2) in pyridine, acetonitrile, and dimethyl sulfoxide, demonstrating that the degree of saturation in the isoprenyl side chain of MK-1 influences the quinone redox potential. quinone 180-187 potassium voltage-gated channel, shaker-related subfamily, member 1 Mus musculus 50-54 30789743-8 2019 The measured quinone redox potentials of MK-1 and MK-1(H2) differed between organic solvents (presumably due to differences in dielectric constants), and remarkably, an ~20 mV semiquinone redox potential difference was observed between MK-1 and MK-1(H2) in pyridine, acetonitrile, and dimethyl sulfoxide, demonstrating that the degree of saturation in the isoprenyl side chain of MK-1 influences the quinone redox potential. quinone 13-20 potassium voltage-gated channel, shaker-related subfamily, member 1 Mus musculus 50-54 30789743-8 2019 The measured quinone redox potentials of MK-1 and MK-1(H2) differed between organic solvents (presumably due to differences in dielectric constants), and remarkably, an ~20 mV semiquinone redox potential difference was observed between MK-1 and MK-1(H2) in pyridine, acetonitrile, and dimethyl sulfoxide, demonstrating that the degree of saturation in the isoprenyl side chain of MK-1 influences the quinone redox potential. quinone 13-20 potassium voltage-gated channel, shaker-related subfamily, member 1 Mus musculus 50-54 30789743-8 2019 The measured quinone redox potentials of MK-1 and MK-1(H2) differed between organic solvents (presumably due to differences in dielectric constants), and remarkably, an ~20 mV semiquinone redox potential difference was observed between MK-1 and MK-1(H2) in pyridine, acetonitrile, and dimethyl sulfoxide, demonstrating that the degree of saturation in the isoprenyl side chain of MK-1 influences the quinone redox potential. quinone 13-20 potassium voltage-gated channel, shaker-related subfamily, member 1 Mus musculus 50-54 30789743-8 2019 The measured quinone redox potentials of MK-1 and MK-1(H2) differed between organic solvents (presumably due to differences in dielectric constants), and remarkably, an ~20 mV semiquinone redox potential difference was observed between MK-1 and MK-1(H2) in pyridine, acetonitrile, and dimethyl sulfoxide, demonstrating that the degree of saturation in the isoprenyl side chain of MK-1 influences the quinone redox potential. quinone 13-20 potassium voltage-gated channel, shaker-related subfamily, member 1 Mus musculus 50-54 30664899-6 2019 Well-known class 2 DHODH inhibitors were tested against SmDHODH and HsDHODH and the results suggest that the variable nature of the quinone-binding tunnel between human and parasite enzymes, as well as the differences in structural plasticity involving rearrangements of the N-terminal alpha-helical domain can be exploited for the design of SmDHODH selective inhibitors, as a strategy to validate DHODH as a drug target against schistosomiasis. quinone 132-139 dihydroorotate dehydrogenase (quinone) Homo sapiens 19-24 30793885-3 2019 These regions both promote the electrocatalytic reduction of oxygen and facilitate the proton coupled electron transfer of quinone groups, integrated into the surface of the sp2 carbon. quinone 123-130 Sp2 transcription factor Homo sapiens 174-177 30664899-6 2019 Well-known class 2 DHODH inhibitors were tested against SmDHODH and HsDHODH and the results suggest that the variable nature of the quinone-binding tunnel between human and parasite enzymes, as well as the differences in structural plasticity involving rearrangements of the N-terminal alpha-helical domain can be exploited for the design of SmDHODH selective inhibitors, as a strategy to validate DHODH as a drug target against schistosomiasis. quinone 132-139 dihydroorotate dehydrogenase (quinone) Homo sapiens 58-63 30616572-3 2019 We hypothesized that shikonin, with a structure similar to that of quinone-type compounds, which are inhibitors of cell division cycle 25 (Cdc25) phosphatases, will have similar effects on Cdc25s. quinone 67-74 cell division cycle 25C Mus musculus 139-144 30448556-0 2019 Overexpression of HIF-1a could partially protect K562 cells from 1,4-benzoquinone induced toxicity by inhibiting ROS, apoptosis and enhancing glycolysis. quinone 65-81 hypoxia inducible factor 1 subunit alpha Homo sapiens 18-24 30541876-7 2019 Metabolites of the sterol, tocopherol, quinone, and sugar classes are differentially accumulated in cry1a and cry2 leaves and fruits. quinone 39-46 cryptochrome 1 Solanum lycopersicum 100-105 30541876-7 2019 Metabolites of the sterol, tocopherol, quinone, and sugar classes are differentially accumulated in cry1a and cry2 leaves and fruits. quinone 39-46 cryptochrome 2 Arabidopsis thaliana 110-114 29030055-11 2019 DOPAL oxidizes spontaneously to DOPAL-quinone, which probably converts alpha-synuclein to its toxic oligomeric form. quinone 38-45 synuclein alpha Homo sapiens 71-86 30898970-7 2019 Analysis of the c-myb (also known as myb)-deficient mutant cmybhkz3 revealed that BQ induced neutrophilia in a c-myb-dependent manner, demonstrating that c-myb is a key intrinsic mediator of BQ hematotoxicity. quinone 82-84 v-myb avian myeloblastosis viral oncogene homolog Danio rerio 16-21 30898970-7 2019 Analysis of the c-myb (also known as myb)-deficient mutant cmybhkz3 revealed that BQ induced neutrophilia in a c-myb-dependent manner, demonstrating that c-myb is a key intrinsic mediator of BQ hematotoxicity. quinone 82-84 v-myb avian myeloblastosis viral oncogene homolog Danio rerio 18-21 30898970-7 2019 Analysis of the c-myb (also known as myb)-deficient mutant cmybhkz3 revealed that BQ induced neutrophilia in a c-myb-dependent manner, demonstrating that c-myb is a key intrinsic mediator of BQ hematotoxicity. quinone 82-84 v-myb avian myeloblastosis viral oncogene homolog Danio rerio 111-116 30898970-7 2019 Analysis of the c-myb (also known as myb)-deficient mutant cmybhkz3 revealed that BQ induced neutrophilia in a c-myb-dependent manner, demonstrating that c-myb is a key intrinsic mediator of BQ hematotoxicity. quinone 82-84 v-myb avian myeloblastosis viral oncogene homolog Danio rerio 111-116 30898970-9 2019 Since c-myb is indispensable for BQ to induce neutrophilia, c-myb could serve as a potential drug target for reversing BQ hematotoxicity. quinone 33-35 v-myb avian myeloblastosis viral oncogene homolog Danio rerio 6-11 30898970-9 2019 Since c-myb is indispensable for BQ to induce neutrophilia, c-myb could serve as a potential drug target for reversing BQ hematotoxicity. quinone 119-121 v-myb avian myeloblastosis viral oncogene homolog Danio rerio 60-65 30504209-2 2019 Although this organism is incapable of fermentative growth in the absence of electron acceptors, its genome encodes LdhA (a putative fermentative NADH-dependent d-lactate dehydrogenase [d-LDH]) and Dld (a respiratory quinone-dependent d-LDH). quinone 217-224 2-hydroxyacid dehydrogenase Shewanella oneidensis MR-1 116-120 30504209-11 2019 Here, we show that LdhA (an NADH-dependent d-LDH) works in concert with Dld (a quinone-dependent d-LDH) to transfer electrons from NADH to quinones during sugar catabolism in S. oneidensis MR-1. quinone 79-86 2-hydroxyacid dehydrogenase Shewanella oneidensis MR-1 19-23 31429367-7 2019 Mycelial growth was highly inhibited by QoI (quinone outside inhibitors) fungicide pyraclostrobin (mean EC50=0.39 microg mL-1) and by DMI (demethylation-inhibiting) fungicide tebuconazole (mean EC50=0.61 microg mL-1), followed by azoxystrobin (mean EC50=2.83 microg mL-1) and flutriafol (mean EC50=2.11 microg mL-1). quinone 45-52 L1 cell adhesion molecule Mus musculus 121-125 30609653-2 2019 Once GGCX is activated, vitamin K is found in the epoxide state, which is then recycled to quinone and hydroquinone states by vitamin K epoxide reductase (VKORC1). quinone 91-98 gamma-glutamyl carboxylase Homo sapiens 5-9 30596633-3 2018 In our previous study, the Tyr98 residue in the caddie protein, which is accommodated in the pocket of active center of tyrosinase, has been found to be converted to a reactive quinone through the formations of the mu-eta2:eta2-peroxo-dicopper(II) and Cu(II)-dopasemiquinone intermediates. quinone 177-184 tyrosinase Homo sapiens 120-130 30596633-3 2018 In our previous study, the Tyr98 residue in the caddie protein, which is accommodated in the pocket of active center of tyrosinase, has been found to be converted to a reactive quinone through the formations of the mu-eta2:eta2-peroxo-dicopper(II) and Cu(II)-dopasemiquinone intermediates. quinone 177-184 DNA polymerase iota Homo sapiens 218-222 30596633-3 2018 In our previous study, the Tyr98 residue in the caddie protein, which is accommodated in the pocket of active center of tyrosinase, has been found to be converted to a reactive quinone through the formations of the mu-eta2:eta2-peroxo-dicopper(II) and Cu(II)-dopasemiquinone intermediates. quinone 177-184 DNA polymerase iota Homo sapiens 223-227 30372857-1 2018 The elevated expression of NQO1 in many human solid tumors along with its ability to activate quinone-based anticancer agents makes it an excellent target for enzyme-directed drug development. quinone 94-101 NAD(P)H quinone dehydrogenase 1 Homo sapiens 27-31 30609653-5 2019 VKORC1 was shown to tightly bind vitamins K1 and MK4 in the epoxide and quinone states, but not in the hydroquinone state; five VKORC1 residues were identified as crucial for vitamin K stabilization, and two other ones were essential for hydrogen bond formation. quinone 72-79 vitamin K epoxide reductase complex subunit 1 Homo sapiens 0-6 30609653-2 2019 Once GGCX is activated, vitamin K is found in the epoxide state, which is then recycled to quinone and hydroquinone states by vitamin K epoxide reductase (VKORC1). quinone 91-98 vitamin K epoxide reductase complex subunit 1 Homo sapiens 126-153 30609653-2 2019 Once GGCX is activated, vitamin K is found in the epoxide state, which is then recycled to quinone and hydroquinone states by vitamin K epoxide reductase (VKORC1). quinone 91-98 vitamin K epoxide reductase complex subunit 1 Homo sapiens 155-161 30282807-6 2018 Our results indicated that HadB is an FMN-dependent quinone reductase that converts the quinone products from HadA to hydroquinone compounds that are more stable and can be assimilated by downstream enzymes in the pathway. quinone 52-59 formin 1 Homo sapiens 38-41 29909523-1 2018 Carnosic acid was used as starting material to synthesize royleanone derivatives featured C11-C14 para quinone. quinone 103-110 RNA polymerase III subunit K Homo sapiens 90-93 30487423-4 2018 NQ-DCP was prepared by conjugating dicyanoisophorone fluoroprobe with hNQO1 activatable quinone propionic acid (QPA), which remain non-fluorescent until activation by tumor-specific hNQO1. quinone 88-95 NAD(P)H quinone dehydrogenase 1 Homo sapiens 70-75 30284752-3 2018 Then, a diastereoselective Diels-Alder reaction of a masked ortho-benzoquinone using the nine-membered ring as a steric shielding group furnished a functionalized 6/6/9 tricyclic skeleton and established the desired stereochemistry at the C3, C7, C12, and C15 positions in one step. quinone 66-78 placenta associated 8 Homo sapiens 256-259 30295471-0 2018 Polybrominated Diphenyl Ethers Quinone Induced Parthanatos-like Cell Death through a Reactive Oxygen Species-Associated Poly(ADP-ribose) Polymerase 1 Signaling. quinone 31-38 poly(ADP-ribose) polymerase 1 Homo sapiens 120-149 30222979-0 2018 Quinone and nitrofurantoin redox cycling by recombinant cytochrome b5 reductase. quinone 0-7 cytochrome b5 type A Homo sapiens 56-69 30062552-6 2018 Hydroquinone, the end product of quinone metabolism by NQO-1, augmented contractions depending on sGC activation but in an endothelium-independent manner. quinone 5-12 NAD(P)H quinone dehydrogenase 1 Sus scrofa 55-60 30222979-6 2018 Using menadione as the substrate, quinone redox cycling was found to inhibit reduction of cytochrome b5 by cytochrome b5 reductase, as measured by heme spectral changes in cytochrome b5. quinone 34-41 mitochondrially encoded cytochrome b Homo sapiens 90-102 30222979-6 2018 Using menadione as the substrate, quinone redox cycling was found to inhibit reduction of cytochrome b5 by cytochrome b5 reductase, as measured by heme spectral changes in cytochrome b5. quinone 34-41 cytochrome b5 type A Homo sapiens 90-103 30222979-6 2018 Using menadione as the substrate, quinone redox cycling was found to inhibit reduction of cytochrome b5 by cytochrome b5 reductase, as measured by heme spectral changes in cytochrome b5. quinone 34-41 cytochrome b5 type A Homo sapiens 107-120 30076846-0 2018 Neuroprotective effects of the cannabigerol quinone derivative VCE-003.2 in SOD1G93A transgenic mice, an experimental model of amyotrophic lateral sclerosis. quinone 44-51 superoxide dismutase 1, soluble Mus musculus 76-80 30062552-6 2018 Hydroquinone, the end product of quinone metabolism by NQO-1, augmented contractions depending on sGC activation but in an endothelium-independent manner. quinone 5-12 guanylate cyclase 1 soluble subunit alpha 1 Rattus norvegicus 98-101 30062552-8 2018 Augmentations of contraction observed with different naturally occurring quinones and with acute hypoxia are initiated by quinone metabolism by NQO-1, in turn interfering with the NO/biased sGC pathway, suggesting a possibly detrimental role of this enzyme in ischemic cardiovascular disorders. quinone 73-80 NAD(P)H quinone dehydrogenase 1 Sus scrofa 144-149 29857489-1 2018 NSC 95397, a quinone-based small molecule compound, has been identified as an inhibitor for dual-specificity phosphatases, including mitogen-activated protein kinase phosphatase-1 (MKP-1). quinone 13-20 dual specificity phosphatase 1 Homo sapiens 133-179 30338226-8 2018 As observed earlier with p-BQ treatment, the initial events of CS exposure were oxidative damage and apoptosis that was followed by persistent signaling through EGFR and MAP kinase pathway. quinone 25-29 epidermal growth factor receptor Cavia porcellus 161-165 29870665-4 2018 We designed and synthesized a library of quinone methide precursors (QMPs) as proposed realkylators of aged AChE. quinone 41-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 29621505-0 2018 Structure of the NDH-2 - HQNO inhibited complex provides molecular insight into quinone-binding site inhibitors. quinone 80-87 NADH-ubiquinone reductase (H(+)-translocating) NDE2 Saccharomyces cerevisiae S288C 17-22 29621505-5 2018 The interaction of HQNO with bacterial NDH-2 is very similar to the native substrate ubiquinone (UQ1) interactions in the yeast Ndi1-UQ1 complex structure, suggesting a conserved mechanism for quinone binding. quinone 88-95 NADH-ubiquinone reductase (H(+)-translocating) NDE2 Saccharomyces cerevisiae S288C 39-44 29648801-5 2018 PRODH is a flavin-dependent enzyme that couples proline oxidation with reduction of membrane-bound quinone, while GSALDH catalyzes the NAD+-dependent oxidation of GSAL to glutamate. quinone 99-106 proline dehydrogenase 1 Homo sapiens 0-5 29592891-2 2018 VKORC1 produces KH2 in 2 reactions: reduction of vitamin K epoxide (KO) to quinone (K), and then KH2 Our dissection of full reduction vs the individual reactions revealed a surprising mechanism of warfarin inhibition. quinone 75-82 vitamin K epoxide reductase complex subunit 1 Homo sapiens 0-6 29592891-2 2018 VKORC1 produces KH2 in 2 reactions: reduction of vitamin K epoxide (KO) to quinone (K), and then KH2 Our dissection of full reduction vs the individual reactions revealed a surprising mechanism of warfarin inhibition. quinone 75-82 potassium voltage-gated channel modifier subfamily G member 1 Homo sapiens 16-19 30063337-2 2018 With hydroquinone (BQH2) and 1,4-benzoquinone (BQ) as redox mediators, the photochemical oxidation of As(III) and reduction of nitrate (NO3-) was carefully investigated. quinone 29-45 NBL1, DAN family BMP antagonist Homo sapiens 136-139 29773554-11 2018 CYP1A2 was found to be the major enzyme involved in the generation of NC quinone metabolites. quinone 73-80 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 0-6 29567065-0 2018 PINK1/Parkin-mediated mitophagy was activated against 1,4-Benzoquinone-induced apoptosis in HL-60 cells. quinone 54-70 PTEN induced kinase 1 Homo sapiens 0-5 29567065-4 2018 This study was designed to investigate whether PINK1/Parkin-mediated mitophagy is activated in 1,4-BQ-treated HL-60 cells, and the roles mitophagy plays in 1,4-BQ-induced apoptosis. quinone 95-101 PTEN induced kinase 1 Homo sapiens 47-52 29567065-5 2018 Our results demonstrated that 1,4-BQ induced autophagy in HL-60 cells, characterized by increased LC3-II/LC3-I ratio and Beclin1 expression, as well as decreased expression of p62. quinone 30-36 beclin 1 Homo sapiens 121-128 29567065-5 2018 Our results demonstrated that 1,4-BQ induced autophagy in HL-60 cells, characterized by increased LC3-II/LC3-I ratio and Beclin1 expression, as well as decreased expression of p62. quinone 30-36 nucleoporin 62 Homo sapiens 176-179 29567065-8 2018 We also confirmed that 1,4-BQ-induced mitophagy was mediated by the PINK1/Parkin pathway, illustrated by increased expression of PINK1 and Parkin mRNA and protein. quinone 23-29 PTEN induced kinase 1 Homo sapiens 68-73 29567065-8 2018 We also confirmed that 1,4-BQ-induced mitophagy was mediated by the PINK1/Parkin pathway, illustrated by increased expression of PINK1 and Parkin mRNA and protein. quinone 23-29 PTEN induced kinase 1 Homo sapiens 129-134 29567065-10 2018 In conclusion, this study demonstrates that the activated PINK1/Parkin-mediated mitophagy exerts a significantly protective effect against 1,4-BQ-induced apoptosis in HL-60 cells. quinone 139-145 PTEN induced kinase 1 Homo sapiens 58-63 29857489-1 2018 NSC 95397, a quinone-based small molecule compound, has been identified as an inhibitor for dual-specificity phosphatases, including mitogen-activated protein kinase phosphatase-1 (MKP-1). quinone 13-20 dual specificity phosphatase 1 Homo sapiens 181-186 29788962-12 2018 As a functional assay for detoxification, compound 2 was the strongest to protect Hepa-1c1c7 against the toxicity of menadione, a quinone substrate for NQO1. quinone 130-137 NAD(P)H dehydrogenase, quinone 1 Mus musculus 152-156 29663060-4 2018 Tyrosinase (TYR) can catalyze adrenaline to generate H2O2, and additionally oxidize the adrenaline to adrenaline quinone. quinone 113-120 tyrosinase Homo sapiens 0-10 29663060-4 2018 Tyrosinase (TYR) can catalyze adrenaline to generate H2O2, and additionally oxidize the adrenaline to adrenaline quinone. quinone 113-120 tyrosinase Homo sapiens 12-15 29505165-5 2018 The results show that PST rapidly reacts with O2.- to yield a unique quinone methide product. quinone 69-76 sulfotransferase family 1A member 1 Homo sapiens 22-25 29526807-6 2018 Moreover, by manipulating the level of QR2 in neuronal cells, including immortalized neuroblast cells and ex vivo neurons isolated from QR2 knockout animals, we showed that there is a direct relationship between QR2-mediated quinone reduction and ROS overproduction. quinone 225-232 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 39-42 29526807-6 2018 Moreover, by manipulating the level of QR2 in neuronal cells, including immortalized neuroblast cells and ex vivo neurons isolated from QR2 knockout animals, we showed that there is a direct relationship between QR2-mediated quinone reduction and ROS overproduction. quinone 225-232 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 136-139 29526807-6 2018 Moreover, by manipulating the level of QR2 in neuronal cells, including immortalized neuroblast cells and ex vivo neurons isolated from QR2 knockout animals, we showed that there is a direct relationship between QR2-mediated quinone reduction and ROS overproduction. quinone 225-232 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 136-139 29638121-6 2018 We also developed bacterial-selective prodrugs (reductively activated quinone-alkyloxycarbonyloxymethyl moiety) to afford HP 87, which demonstrated excellent antibacterial and biofilm eradication activities against MRSA BAA-1707 (MIC = 0.15 muM, MBEC = 12.5 muM). quinone 70-77 latexin Homo sapiens 241-244 29638121-6 2018 We also developed bacterial-selective prodrugs (reductively activated quinone-alkyloxycarbonyloxymethyl moiety) to afford HP 87, which demonstrated excellent antibacterial and biofilm eradication activities against MRSA BAA-1707 (MIC = 0.15 muM, MBEC = 12.5 muM). quinone 70-77 latexin Homo sapiens 258-261 29523543-8 2018 The respiration modes found in the anoxic zone continue into shallow subsurface sediments, but quinone abundances rapidly decrease within the upper 50 cm below the sea floor, reflecting the transition to lower energy availability. quinone 95-102 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 164-167 29345430-3 2018 In the presence of the surface TYR biomarker, the immobilized catechol is rapidly converted to benzoquinone that is detected amperometrically, with a current signal proportional to the TYR level. quinone 95-107 tyrosinase Homo sapiens 31-34 29345430-3 2018 In the presence of the surface TYR biomarker, the immobilized catechol is rapidly converted to benzoquinone that is detected amperometrically, with a current signal proportional to the TYR level. quinone 95-107 tyrosinase Homo sapiens 185-188 29281794-1 2018 Detoxicating enzymes NAD(P)H:quinone oxidoreductase 1 (NQO1) and NRH:quinone oxidoreductase 2 (NQO2) catalyze the two-electron reduction of quinone-like compounds. quinone 29-36 NAD(P)H quinone dehydrogenase 1 Homo sapiens 55-59 29506454-5 2018 The results demonstrated that 1,4-BQ could dose-dependently induce production of ROS and mitochondrial damage as characterized by mitochondrial membrane potential disruption, mitochondrial ultrastructure alteration, and induced apoptosis and activated caspase-3 and caspase-9. quinone 30-36 caspase 3 Homo sapiens 252-261 29506454-5 2018 The results demonstrated that 1,4-BQ could dose-dependently induce production of ROS and mitochondrial damage as characterized by mitochondrial membrane potential disruption, mitochondrial ultrastructure alteration, and induced apoptosis and activated caspase-3 and caspase-9. quinone 30-36 caspase 9 Homo sapiens 266-275 29506454-6 2018 Preincubation of HL-60 cells with NAC prior to 1,4-BQ treatment could block 1,4-BQ-induced production of ROS and the occurrence of apoptosis. quinone 76-82 X-linked Kx blood group Homo sapiens 34-37 29281794-1 2018 Detoxicating enzymes NAD(P)H:quinone oxidoreductase 1 (NQO1) and NRH:quinone oxidoreductase 2 (NQO2) catalyze the two-electron reduction of quinone-like compounds. quinone 29-36 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 65-93 29281794-1 2018 Detoxicating enzymes NAD(P)H:quinone oxidoreductase 1 (NQO1) and NRH:quinone oxidoreductase 2 (NQO2) catalyze the two-electron reduction of quinone-like compounds. quinone 29-36 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 95-99 29281794-3 2018 In the current study, we quantified the concentrations of NQO1 and NQO2 in 20 human liver donors and NQO1 and NQO2 activities with quinone-like drug metabolites. quinone 131-138 NAD(P)H quinone dehydrogenase 1 Homo sapiens 101-105 29281794-3 2018 In the current study, we quantified the concentrations of NQO1 and NQO2 in 20 human liver donors and NQO1 and NQO2 activities with quinone-like drug metabolites. quinone 131-138 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 110-114 29281794-7 2018 NQO2 catalyzed the reduction of quinone-like metabolites derived from acetaminophen, clozapine, 4"-hydroxydiclofenac, mefenamic acid, amodiaquine, and carbamazepine. quinone 32-39 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 0-4 29281794-11 2018 While the in vivo relevance of NQO2-catalyzed reduction of quinone-like metabolites remains to be established by identification of the physiologically relevant co-substrates, our results suggest an additional protective role of the NQO2 protein by non-enzymatic scavenging of quinone-like metabolites. quinone 59-66 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 31-35 29281794-11 2018 While the in vivo relevance of NQO2-catalyzed reduction of quinone-like metabolites remains to be established by identification of the physiologically relevant co-substrates, our results suggest an additional protective role of the NQO2 protein by non-enzymatic scavenging of quinone-like metabolites. quinone 59-66 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 232-236 29281794-11 2018 While the in vivo relevance of NQO2-catalyzed reduction of quinone-like metabolites remains to be established by identification of the physiologically relevant co-substrates, our results suggest an additional protective role of the NQO2 protein by non-enzymatic scavenging of quinone-like metabolites. quinone 276-283 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 31-35 29281794-11 2018 While the in vivo relevance of NQO2-catalyzed reduction of quinone-like metabolites remains to be established by identification of the physiologically relevant co-substrates, our results suggest an additional protective role of the NQO2 protein by non-enzymatic scavenging of quinone-like metabolites. quinone 276-283 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 232-236 29281794-12 2018 Hepatic NQO1 activity in detoxication of quinone-like metabolites becomes especially important when other detoxication pathways are exhausted and NQO1 levels are induced. quinone 41-48 NAD(P)H quinone dehydrogenase 1 Homo sapiens 8-12 29281794-12 2018 Hepatic NQO1 activity in detoxication of quinone-like metabolites becomes especially important when other detoxication pathways are exhausted and NQO1 levels are induced. quinone 41-48 NAD(P)H quinone dehydrogenase 1 Homo sapiens 146-150 29439519-3 2018 We found that the oxidation of racemic RD by mushroom tyrosinase rapidly produces RD-quinone, which gives rise to secondary quinone products. quinone 85-92 tyrosinase Homo sapiens 54-64 29464564-5 2018 The overall rate of the intersystem electron transport is determined by PQH2 turnover at the quinone-binding site Qo of the Cyt b 6 f complex. quinone 93-100 mitochondrially encoded cytochrome b Homo sapiens 124-129 29096305-0 2018 VNN3, a potential novel biomarker for benzene toxicity, is involved in 1, 4-benzoquinone induced cell proliferation. quinone 71-88 vanin 3, pseudogene Homo sapiens 0-4 29096305-4 2018 The aim of this study was to investigate the effect and mechanism of VNN3 on cell proliferation induced by 1,4-benzoquinone (1,4-BQ), an important metabolite of benzene, and obtain a sensitive biomarker for the hazard screening and health care of benzene exposure. quinone 107-123 vanin 3, pseudogene Homo sapiens 69-73 29096305-4 2018 The aim of this study was to investigate the effect and mechanism of VNN3 on cell proliferation induced by 1,4-benzoquinone (1,4-BQ), an important metabolite of benzene, and obtain a sensitive biomarker for the hazard screening and health care of benzene exposure. quinone 125-131 vanin 3, pseudogene Homo sapiens 69-73 29096305-8 2018 The results showed that 1,4-BQ clearly increased the expression of VNN3. quinone 24-30 vanin 3, pseudogene Homo sapiens 67-71 29096305-9 2018 Moreover, 1,4-BQ dose-dependently inhibited cell proliferation and caused increased KLF15 expression; in contrast, the NOTCH1 expression decreased in AHH-1 cells. quinone 10-16 Kruppel like factor 15 Homo sapiens 84-89 29064673-4 2018 In prokaryotes, disulfide generation is coupled to quinone reduction, catalyzed by intramembrane donor enzymes, DsbB and VKOR. quinone 51-58 vitamin K epoxide reductase complex subunit 1 Homo sapiens 121-125 28643389-0 2018 Combined molecular modelling and 3D-QSAR study for understanding the inhibition of NQO1 by heterocyclic quinone derivatives. quinone 104-111 NAD(P)H quinone dehydrogenase 1 Homo sapiens 83-87 28919435-5 2017 Bound human IgE (humIgE) was detected by an anti-humIgE antibody through a quantitative amperometric determination by tracking via the electrochemical reduction of the quinone generated from the hydroquinone with the application of a potential of 25 mV. quinone 168-175 immunoglobulin heavy constant epsilon Homo sapiens 12-15 28960782-5 2018 In Saccharomyces cerevisiae, amino acid substitutions N31K, G37C and L198F at the Qi quinone binding site of cytochrome b reduced sensitivity to fenpicoxamid, UK-2A and antimycin A. quinone 85-92 cytochrome b Saccharomyces cerevisiae S288C 109-121 28986286-8 2018 GATA3 and Bmi-1 expressions were also significant upregulated at 2.5 and 5muM 1,4-BQ, respectively. quinone 78-84 GATA binding protein 3 Mus musculus 0-5 28986286-8 2018 GATA3 and Bmi-1 expressions were also significant upregulated at 2.5 and 5muM 1,4-BQ, respectively. quinone 78-84 Bmi1 polycomb ring finger oncogene Mus musculus 10-15 29108775-8 2018 In addition, overexpression and knockdown of NQO1 augmented and lowered, respectively, the ROS production through PQ redox-cycling and the quinone toxicity. quinone 139-146 NAD(P)H quinone dehydrogenase 1 Homo sapiens 45-49 30112966-6 2018 We moreover observed that 6-OHDA-derived electrophilic quinone induced oxidative stress as indicated by a decrease in glutathione levels, and that this was suppressed by pretreatment with antioxidant NAC. quinone 55-62 synuclein alpha Homo sapiens 200-203 28643389-7 2018 The good concordance between the docking results and 3D-QSAR contour maps provides helpful information about a rational modification of new molecules based in quinone scaffold, in order to design more potent NQO1 inhibitors, which would exhibit highly potent antitumor activity. quinone 159-166 NAD(P)H quinone dehydrogenase 1 Homo sapiens 208-212 29085018-6 2017 In electron acceptor side, electron transport efficiency from quinone B to photosystem I acceptors increased under high Cd2+ treatments, which may be an important response for plants against Cd2+ toxicity and its mechanism needs our further study. quinone 62-69 CD2 molecule Homo sapiens 120-123 28849207-2 2017 Previous studies have reported that Tanshinone IIA (TSA), a major quinone compound isolated from Salvia miltiorrhiza, had antitumor effects. quinone 66-73 ATPase, class II, type 9A Mus musculus 47-50 28970059-7 2017 Compared with the dihydroxy compound, the quinone analog induced Hmox1 more potently in HAEC and also provided enhanced protection to arteries of wild type animals against oxidant-induced endothelial dysfunction. quinone 42-49 heme oxygenase 1 Mus musculus 65-70 28994029-2 2017 The binding site and mode of quinone inhibitors to Cdc25B remains unclear, whereas this information is important for structure-based drug design. quinone 29-36 cell division cycle 25B Homo sapiens 51-57 29085018-6 2017 In electron acceptor side, electron transport efficiency from quinone B to photosystem I acceptors increased under high Cd2+ treatments, which may be an important response for plants against Cd2+ toxicity and its mechanism needs our further study. quinone 62-69 CD2 molecule Homo sapiens 191-194 29025057-1 2017 NRH: quinone oxidoreductase 2 (NQO2) is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone to hydroquinones. quinone 5-12 N-ribosyldihydronicotinamide quinone reductase 2 Mus musculus 31-35 28986540-1 2017 The irritant receptor TRPA1 was suggested to mediate analgesic, antipyretic but also pro-inflammatory effects of the non-opioid analgesic acetaminophen, presumably due to channel activation by the reactive metabolites parabenzoquinone (pBQ) and N-acetyl-parabenzoquinonimine (NAPQI). quinone 218-234 transient receptor potential cation channel subfamily A member 1 Homo sapiens 22-27 28986540-1 2017 The irritant receptor TRPA1 was suggested to mediate analgesic, antipyretic but also pro-inflammatory effects of the non-opioid analgesic acetaminophen, presumably due to channel activation by the reactive metabolites parabenzoquinone (pBQ) and N-acetyl-parabenzoquinonimine (NAPQI). quinone 236-239 transient receptor potential cation channel subfamily A member 1 Homo sapiens 22-27 28986540-3 2017 Both pBQ and NAPQI, but not acetaminophen irreversibly activated and sensitized recombinant human and rodent TRPV1 channels expressed in HEK 293 cells. quinone 5-8 transient receptor potential cation channel subfamily V member 1 Homo sapiens 109-114 28986540-8 2017 Our data demonstrate that pBQ and NAQPI activate and sensitize TRPV1 by interacting with intracellular cysteines. quinone 26-29 transient receptor potential cation channel subfamily V member 1 Homo sapiens 63-68 28847921-0 2017 A Bacterial Multidomain NAD-Independent d-Lactate Dehydrogenase Utilizes Flavin Adenine Dinucleotide and Fe-S Clusters as Cofactors and Quinone as an Electron Acceptor for d-Lactate Oxidization. quinone 136-143 FAD-binding oxidoreductase Pseudomonas putida KT2440 40-63 28499769-11 2017 In vivo experiments with a PST2 knock out and overexpressing strain demonstrated that Pst2p enables yeast cells to cope with quinone-induced damage suggesting a role of the enzyme in managing oxidative stress. quinone 125-132 flavodoxin-like fold family protein Saccharomyces cerevisiae S288C 27-31 28544013-8 2017 These results suggested that EGCg might allosterically inhibit the ACE activity through oxidative conversion into an electrophilic quinone. quinone 131-138 angiotensin I converting enzyme Homo sapiens 67-70 28883796-4 2017 Established roles of NQO1 include its ability to prevent certain quinones from one electron redox cycling but its role in quinone detoxification is dependent on the redox stability of the hydroquinone generated by two-electron reduction. quinone 65-72 NAD(P)H quinone dehydrogenase 1 Homo sapiens 21-25 28688915-16 2017 NQO1 exerts its cytoprotective activity by detoxifying electrophilic and oxidative xenobiotics with quinone structure. quinone 100-107 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-4 28639727-3 2017 Following a large screening for ubiquitin specific protease 2 (USP2) inhibition, an effective para-quinone-based inhibitor with an unclear mode of action was identified. quinone 94-106 ubiquitin specific peptidase 2 Homo sapiens 32-61 28639727-3 2017 Following a large screening for ubiquitin specific protease 2 (USP2) inhibition, an effective para-quinone-based inhibitor with an unclear mode of action was identified. quinone 94-106 ubiquitin specific peptidase 2 Homo sapiens 63-67 28499769-11 2017 In vivo experiments with a PST2 knock out and overexpressing strain demonstrated that Pst2p enables yeast cells to cope with quinone-induced damage suggesting a role of the enzyme in managing oxidative stress. quinone 125-132 flavodoxin-like fold family protein Saccharomyces cerevisiae S288C 86-91 28595002-6 2017 Using 9,10-phenanthrenequinone as the substrate, quinone redox cycling was found to inhibit DCXR reduction of l-xylulose and diacetyl. quinone 23-30 dicarbonyl and L-xylulose reductase Homo sapiens 92-96 28676501-3 2017 Here, we identified a novel mechanism of generating appropriate levels of ROS at the plasma membrane through a peroxidase and dual oxidase (DUOX) system, which could extend lifespan in Caenorhabditis elegans A redox co-factor, pyrroloquinoline quinone (PQQ), activates the C. elegans DUOX protein BLI-3 to produce the ROS H2O2 at the plasma membrane, which is subsequently degraded by peroxidase (MLT-7), eventually ensuring adequate levels of ROS. quinone 244-251 NAD(P)H oxidase (H(2)O(2)-forming) Caenorhabditis elegans 126-138 28676501-3 2017 Here, we identified a novel mechanism of generating appropriate levels of ROS at the plasma membrane through a peroxidase and dual oxidase (DUOX) system, which could extend lifespan in Caenorhabditis elegans A redox co-factor, pyrroloquinoline quinone (PQQ), activates the C. elegans DUOX protein BLI-3 to produce the ROS H2O2 at the plasma membrane, which is subsequently degraded by peroxidase (MLT-7), eventually ensuring adequate levels of ROS. quinone 244-251 NAD(P)H oxidase (H(2)O(2)-forming) Caenorhabditis elegans 140-144 28676501-3 2017 Here, we identified a novel mechanism of generating appropriate levels of ROS at the plasma membrane through a peroxidase and dual oxidase (DUOX) system, which could extend lifespan in Caenorhabditis elegans A redox co-factor, pyrroloquinoline quinone (PQQ), activates the C. elegans DUOX protein BLI-3 to produce the ROS H2O2 at the plasma membrane, which is subsequently degraded by peroxidase (MLT-7), eventually ensuring adequate levels of ROS. quinone 244-251 NAD(P)H oxidase (H(2)O(2)-forming) Caenorhabditis elegans 284-288 28676501-3 2017 Here, we identified a novel mechanism of generating appropriate levels of ROS at the plasma membrane through a peroxidase and dual oxidase (DUOX) system, which could extend lifespan in Caenorhabditis elegans A redox co-factor, pyrroloquinoline quinone (PQQ), activates the C. elegans DUOX protein BLI-3 to produce the ROS H2O2 at the plasma membrane, which is subsequently degraded by peroxidase (MLT-7), eventually ensuring adequate levels of ROS. quinone 244-251 Dual oxidase 1 Caenorhabditis elegans 297-302 28676501-3 2017 Here, we identified a novel mechanism of generating appropriate levels of ROS at the plasma membrane through a peroxidase and dual oxidase (DUOX) system, which could extend lifespan in Caenorhabditis elegans A redox co-factor, pyrroloquinoline quinone (PQQ), activates the C. elegans DUOX protein BLI-3 to produce the ROS H2O2 at the plasma membrane, which is subsequently degraded by peroxidase (MLT-7), eventually ensuring adequate levels of ROS. quinone 244-251 Peroxidase mlt-7 light chain Caenorhabditis elegans 397-402 28456030-4 2017 An older study reports that 1,4-benzoquinone inhibits MAO-A and MAO-B from human synaptosomes. quinone 28-44 monoamine oxidase A Homo sapiens 54-59 28456030-4 2017 An older study reports that 1,4-benzoquinone inhibits MAO-A and MAO-B from human synaptosomes. quinone 28-44 monoamine oxidase B Homo sapiens 64-69 28456030-8 2017 These values are comparable to those recorded for 1,4-benzoquinone of 4.82 muM (MAO-A) and 10.2 muM (MAO-B). quinone 50-66 latexin Homo sapiens 75-78 28456030-8 2017 These values are comparable to those recorded for 1,4-benzoquinone of 4.82 muM (MAO-A) and 10.2 muM (MAO-B). quinone 50-66 monoamine oxidase A Homo sapiens 80-85 28524357-4 2017 For the construction of antibody-probe conjugates from an anti-carcinoembryonic antigen and a quinone-caged profluorescent naphthalimide derivative, the dual "click" coupling process with C1 was monitored on the basis of the emission turn-on of C1, whereas prominent changes in FRET ratios occurred for antibody-imaging-probe conjugates when specifically triggered by quinone oxidoreductase (NQO1), which is overexpressed in various types of cancer cells. quinone 94-101 crystallin zeta Homo sapiens 368-390 28524357-4 2017 For the construction of antibody-probe conjugates from an anti-carcinoembryonic antigen and a quinone-caged profluorescent naphthalimide derivative, the dual "click" coupling process with C1 was monitored on the basis of the emission turn-on of C1, whereas prominent changes in FRET ratios occurred for antibody-imaging-probe conjugates when specifically triggered by quinone oxidoreductase (NQO1), which is overexpressed in various types of cancer cells. quinone 94-101 NAD(P)H quinone dehydrogenase 1 Homo sapiens 392-396 28431339-2 2017 Here, we describe the development of two novel quinone-polycycle series of CDC25A and C inhibitors on the one hand 1a-k, coumarin-based, and on the other 2a-g, quinolinone-based, which inhibit either enzymes up to a sub-micro molar level and at single-digit micro molar concentrations, respectively. quinone 47-54 cell division cycle 25A Homo sapiens 75-81 28448872-7 2017 Furthermore, we found that curcumin up-regulated the expression of nuclear Nrf2 and Nrf2-dependent antioxidant defense genes including heme oxygenase-1 (HO-1), glutamate-cysteine ligase (GCLC), NAD(P)H dehydrogenase, and quinone (NQO-1) in a dose-dependent manner. quinone 221-228 NFE2 like bZIP transcription factor 2 Rattus norvegicus 75-79 28448872-7 2017 Furthermore, we found that curcumin up-regulated the expression of nuclear Nrf2 and Nrf2-dependent antioxidant defense genes including heme oxygenase-1 (HO-1), glutamate-cysteine ligase (GCLC), NAD(P)H dehydrogenase, and quinone (NQO-1) in a dose-dependent manner. quinone 221-228 NFE2 like bZIP transcription factor 2 Rattus norvegicus 84-88 28443879-3 2017 Treatment of homoleptic CeIV and CeIII Me2pz complexes with 1,4-hydroquinone (H2hq) or 1,4-benzoquinone (bq), respectively, ultimately gave the same trimetallic CeIII species via a cerium redox equilibrium. quinone 87-103 malic enzyme 2 Homo sapiens 39-42 28388563-4 2017 In vitro experiments, 1,4-Benzoquinone dose-dependently inhibited cell proliferation and simultaneously caused the decrease of NOTCH1 expression and the increase of KLF15 in AHH-1 cell lines. quinone 22-38 notch receptor 1 Homo sapiens 127-133 28388563-4 2017 In vitro experiments, 1,4-Benzoquinone dose-dependently inhibited cell proliferation and simultaneously caused the decrease of NOTCH1 expression and the increase of KLF15 in AHH-1 cell lines. quinone 22-38 Kruppel like factor 15 Homo sapiens 165-170 28388563-5 2017 Meanwhile, 1, 4-Benzoquinone obviously increased the expression of lncRNA-OBFC2A, which was consistent with our previous population results. quinone 11-28 nucleic acid binding protein 1 Homo sapiens 74-80 28388563-8 2017 After interfering lncRNA-OBFC2A, the cell proliferation inhibition and the expression of NOTCH1 and KLF15 induced by 1, 4-Benzoquinone were reversed. quinone 117-134 nucleic acid binding protein 1 Homo sapiens 25-31 28388563-8 2017 After interfering lncRNA-OBFC2A, the cell proliferation inhibition and the expression of NOTCH1 and KLF15 induced by 1, 4-Benzoquinone were reversed. quinone 117-134 notch receptor 1 Homo sapiens 89-95 28388563-8 2017 After interfering lncRNA-OBFC2A, the cell proliferation inhibition and the expression of NOTCH1 and KLF15 induced by 1, 4-Benzoquinone were reversed. quinone 117-134 Kruppel like factor 15 Homo sapiens 100-105 27677293-0 2017 A Quinone-Containing Compound Enhances Camptothecin-Induced Apoptosis of Lung Cancer Through Modulating Endogenous ROS and ERK Signaling. quinone 2-9 mitogen-activated protein kinase 1 Homo sapiens 123-126 28440548-6 2017 Further examination of a broad panel of contact sensitizers revealed 1,4-benzoquinone, resorcinol, isoeugenol, and cinnamaldehyde to activate the same type of CD1-restricted responses. quinone 69-85 CD1a molecule Homo sapiens 159-162 28959653-0 2017 p-Benzoquinone initiates non-invasive urothelial cancer through aberrant tyrosine phosphorylation of EGFR, MAP kinase activation and cell cycle deregulation: Prevention by vitamin C. quinone 0-14 epidermal growth factor receptor Cavia porcellus 101-105 28959653-7 2017 The mechanisms of carcinogenesis were p-BQ-induced oxidative damage and apoptosis that were later suppressed and followed by activation of epidermal growth factor receptor, aberrant phosphorylation of intracellular tyrosine residues, activation of MAP kinase pathway and persistent growth signaling. quinone 38-42 epidermal growth factor receptor Cavia porcellus 139-171 28572558-1 2017 Pyrroloquinoline quinone (PQQ) is a water-soluble quinone compound first identified as a cofactor of alcohol- and glucose-dehydrogenases (ADH and GDH) in bacteria. quinone 17-24 hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase Homo sapiens 146-149 28443879-3 2017 Treatment of homoleptic CeIV and CeIII Me2pz complexes with 1,4-hydroquinone (H2hq) or 1,4-benzoquinone (bq), respectively, ultimately gave the same trimetallic CeIII species via a cerium redox equilibrium. quinone 105-107 malic enzyme 2 Homo sapiens 39-42 28240865-3 2017 Human NAD(P)H:quinone oxidoreductase isozyme I (hNQO1), a cytoprotective 2-electron-specific reductase found at unusually high activity levels in cancer cells of multiple origins, has attracted significant attention due to its major role in metastatic pathways and its link to low survival rates in patients, as well as its ability to effectively activate quinone-based, anticancer drugs. quinone 14-21 NAD(P)H quinone dehydrogenase 1 Homo sapiens 48-53 28193656-5 2017 All mutations underlying atovaquone resistance selected by RIaT (M133I, T142N, and L144S) were found to be in the Qo1 (quinone binding 1) domain of the mitochondrial cytochrome b gene, in contrast to those selected by RIcT (Y268N/C, L271V, K272R, and V284F) in the Qo2 domain or its neighboring sixth transmembrane region. quinone 119-126 cytochrome b, mitochondrial Mus musculus 166-178 28286015-8 2017 LC-MS/MS analysis indicated that rutin quinone targets cysteine 151 of Keap1. quinone 39-46 kelch like ECH associated protein 1 Homo sapiens 71-76 28286015-12 2017 CONCLUSION AND SIGNIFICANCE: Rutin functions as an antioxidant and is oxidized into a quinone that upregulates the Nrf2-mediated endogenous antioxidant response. quinone 86-93 NFE2 like bZIP transcription factor 2 Homo sapiens 115-119 28236663-3 2017 The activity of NQO1 is also exploited in chemotherapy for the activation of quinone-based treatments. quinone 77-84 NAD(P)H quinone dehydrogenase 1 Homo sapiens 16-20 28240865-5 2017 Herein, we disclose a quinone-trigger-based, near-infrared probe whose fluorescence is effectively turned on several hundred-fold through highly selective reduction of the quinone trigger group by hNQO1, with unprecedented, catalytically efficient formation of a fluorescent reporter. quinone 22-29 NAD(P)H quinone dehydrogenase 1 Homo sapiens 197-202 28240865-5 2017 Herein, we disclose a quinone-trigger-based, near-infrared probe whose fluorescence is effectively turned on several hundred-fold through highly selective reduction of the quinone trigger group by hNQO1, with unprecedented, catalytically efficient formation of a fluorescent reporter. quinone 172-179 NAD(P)H quinone dehydrogenase 1 Homo sapiens 197-202 28490186-7 2017 The selected descriptors are in accordance with the literature, once C10 and C1 are bound or close to the quinone oxygens involved in the production of radical anions (O2- ). quinone 106-113 homeobox C10 Homo sapiens 69-72 28214631-0 2017 Discovery of quinone-directed antitumor agents selectively bioactivated by NQO1 over CPR with improved safety profile. quinone 13-20 NAD(P)H quinone dehydrogenase 1 Homo sapiens 75-79 28214631-0 2017 Discovery of quinone-directed antitumor agents selectively bioactivated by NQO1 over CPR with improved safety profile. quinone 13-20 cytochrome p450 oxidoreductase Homo sapiens 85-88 28214631-3 2017 Several novel quinone-directed antitumor agents were discovered as specific NQO1 substrates through structure-activity relationship studies. quinone 14-21 NAD(P)H quinone dehydrogenase 1 Homo sapiens 76-80 28159840-5 2017 Using various soluble quinone derivatives (e.g. ubiquinones), we reveal a new path of down-regulation of AHAS activity involving inhibition by oxidized redox-signaling molecules. quinone 22-29 ilvB acetolactate synthase like Homo sapiens 105-109 28219012-5 2017 The results of this study demonstrate that the oxidation of RK by mushroom tyrosinase rapidly produces 4-(3-oxobutyl)-1,2-benzoquinone (RK-quinone), which is converted within 10-20 min to (E)-4-(3-oxo-1-butenyl)-1,2-benzoquinone (DBL-quinone). quinone 127-134 tyrosinase Homo sapiens 75-85 28219012-5 2017 The results of this study demonstrate that the oxidation of RK by mushroom tyrosinase rapidly produces 4-(3-oxobutyl)-1,2-benzoquinone (RK-quinone), which is converted within 10-20 min to (E)-4-(3-oxo-1-butenyl)-1,2-benzoquinone (DBL-quinone). quinone 127-134 MCF.2 cell line derived transforming sequence Homo sapiens 230-233 28219012-8 2017 DBL-quinone is more reactive than RK-quinone, as judged by their half-lives (6.2 min vs 10.5 min, respectively), and decays rapidly to form an oligomeric pigment (RK-oligomer). quinone 4-11 MCF.2 cell line derived transforming sequence Homo sapiens 0-3 28032259-11 2017 We propose that NQR and AIR12 interact via the quinone, allowing an electron transfer from cytosolic NAD(P)H to apoplastic monodehydroascorbate and control thereby the level of reactive oxygen production and the redox state of the apoplast. quinone 47-54 ARP protein (REF) Arabidopsis thaliana 16-19 28032259-11 2017 We propose that NQR and AIR12 interact via the quinone, allowing an electron transfer from cytosolic NAD(P)H to apoplastic monodehydroascorbate and control thereby the level of reactive oxygen production and the redox state of the apoplast. quinone 47-54 plasma membrane ascorbate-reducible b-type cytochrome family protein Glycine max 24-29 28056492-7 2017 Probing interactions of analogues of the two quinone units of IRC-083864 with CDC25B demonstrate that IRC-083864 competes with each monomer. quinone 45-52 cell division cycle 25B Homo sapiens 78-84 27939626-11 2017 Results revealed that 1,4-benzoquinone induced abnormal cell apoptosis and simultaneously upregulated miR-34a accompanied with decreased Bcl-2. quinone 22-38 microRNA 34a Homo sapiens 102-109 28107924-2 2017 Briefly, the thiol addition reaction of a gold electrode-supported 1,6-hexanedithiol (HDT) with p-benzoquinone (BQ) yielded BQ-HDT/Au, and the similar reaction of thiolated thrombin aptamer (TTA) with activated BQ-HDT/Au under 0.3V led to formation of a gold electrode-supported novel electrochemical probe TTA-BQ-HDT/Au. quinone 96-110 coagulation factor II, thrombin Homo sapiens 173-181 28107924-2 2017 Briefly, the thiol addition reaction of a gold electrode-supported 1,6-hexanedithiol (HDT) with p-benzoquinone (BQ) yielded BQ-HDT/Au, and the similar reaction of thiolated thrombin aptamer (TTA) with activated BQ-HDT/Au under 0.3V led to formation of a gold electrode-supported novel electrochemical probe TTA-BQ-HDT/Au. quinone 112-114 coagulation factor II, thrombin Homo sapiens 173-181 28107924-3 2017 The thus-prepared TTA-BQ-HDT/Au exhibits a pair of well-defined redox peaks of quinone moiety, and the TTA-thrombin interaction can sensitively decrease the electrochemical signal. quinone 79-86 coagulation factor II, thrombin Homo sapiens 107-115 27836196-0 2017 Optimization of benzoquinone and hydroquinone derivatives as potent inhibitors of human 5-lipoxygenase. quinone 16-28 arachidonate 5-lipoxygenase Homo sapiens 88-102 27939626-0 2017 MiR-34a, a promising novel biomarker for benzene toxicity, is involved in cell apoptosis triggered by 1,4-benzoquinone through targeting Bcl-2. quinone 102-118 microRNA 34a Homo sapiens 0-7 27939626-0 2017 MiR-34a, a promising novel biomarker for benzene toxicity, is involved in cell apoptosis triggered by 1,4-benzoquinone through targeting Bcl-2. quinone 102-118 BCL2 apoptosis regulator Homo sapiens 137-142 28107924-1 2017 Effective covalent immobilization of quinone and aptamer onto a gold electrode via thiol addition (a Michael addition) for sensitive and selective protein (with thrombin as the model) biosensing is reported, with a detection limit down to 20 fM for thrombin. quinone 37-44 coagulation factor II, thrombin Homo sapiens 161-169 28107924-1 2017 Effective covalent immobilization of quinone and aptamer onto a gold electrode via thiol addition (a Michael addition) for sensitive and selective protein (with thrombin as the model) biosensing is reported, with a detection limit down to 20 fM for thrombin. quinone 37-44 coagulation factor II, thrombin Homo sapiens 249-257 27939626-11 2017 Results revealed that 1,4-benzoquinone induced abnormal cell apoptosis and simultaneously upregulated miR-34a accompanied with decreased Bcl-2. quinone 22-38 BCL2 apoptosis regulator Homo sapiens 137-142 27939626-12 2017 Finally, inhibition of miR-34a elevated Bcl-2 and decreased 1,4-benzoquinone-induced apoptosis. quinone 60-76 microRNA 34a Homo sapiens 23-30 27878233-0 2017 Benzoquinone from Fusarium pigment inhibits the proliferation of estrogen receptor-positive MCF-7 cells through the NF-kappaB pathway via estrogen receptor signaling. quinone 0-12 estrogen receptor 1 Homo sapiens 65-82 27986568-1 2017 Deoxynyboquinone (DNQ), a potent novel quinone-based antineoplastic agent, selectively kills solid cancers with overexpressed cytosolic NAD(P)H:quinone oxidoreductase-1 (NQO1) via excessive ROS production. quinone 9-16 NAD(P)H quinone dehydrogenase 1 Homo sapiens 136-168 27986568-1 2017 Deoxynyboquinone (DNQ), a potent novel quinone-based antineoplastic agent, selectively kills solid cancers with overexpressed cytosolic NAD(P)H:quinone oxidoreductase-1 (NQO1) via excessive ROS production. quinone 9-16 NAD(P)H quinone dehydrogenase 1 Homo sapiens 170-174 27438141-7 2017 We speculate that an electrophilic quinone formed as a consequence of oxidation of 4-OHE2 binds directly to Kelch-like ECH-associated protein 1 (Keap1), an inhibitory protein that sequesters Nrf2 in the cytoplasm. quinone 35-42 kelch like ECH associated protein 1 Homo sapiens 108-143 27438141-7 2017 We speculate that an electrophilic quinone formed as a consequence of oxidation of 4-OHE2 binds directly to Kelch-like ECH-associated protein 1 (Keap1), an inhibitory protein that sequesters Nrf2 in the cytoplasm. quinone 35-42 kelch like ECH associated protein 1 Homo sapiens 145-150 27438141-7 2017 We speculate that an electrophilic quinone formed as a consequence of oxidation of 4-OHE2 binds directly to Kelch-like ECH-associated protein 1 (Keap1), an inhibitory protein that sequesters Nrf2 in the cytoplasm. quinone 35-42 NFE2 like bZIP transcription factor 2 Homo sapiens 191-195 27959364-1 2017 A new quinone propionic acid locked TP fluorophore which can be used for human NAD(P)H:quinone oxidoreductase (hNQO1) detection was developed. quinone 6-13 2,4-dienoyl-CoA reductase 1 Homo sapiens 79-86 27959364-1 2017 A new quinone propionic acid locked TP fluorophore which can be used for human NAD(P)H:quinone oxidoreductase (hNQO1) detection was developed. quinone 6-13 NAD(P)H quinone dehydrogenase 1 Homo sapiens 111-116 27878233-0 2017 Benzoquinone from Fusarium pigment inhibits the proliferation of estrogen receptor-positive MCF-7 cells through the NF-kappaB pathway via estrogen receptor signaling. quinone 0-12 estrogen receptor 1 Homo sapiens 138-155 27764794-0 2016 The BET bromodomain inhibitor exerts the most potent synergistic anticancer effects with quinone-containing compounds and anti-microtubule drugs. quinone 89-96 delta/notch like EGF repeat containing Homo sapiens 4-7 27934368-2 2016 A new approach for the enantioselective synthesis of monosubstituted quinone-DA adducts is presented based on C(sp2)-H alkylative desymmetrization of meso-DA adducts. quinone 69-76 Sp2 transcription factor Homo sapiens 110-115 26873738-6 2016 Our results show that CSK contains a modified kinase catalytic domain that binds ATP with high affinity and forms a quinone adduct that may confer redox sensing activity. quinone 116-123 chloroplast sensor kinase Arabidopsis thaliana 22-25 27770725-9 2016 While SYR showed the least reactivity due to the formation of para-quinone intermediates. quinone 62-74 YES1 pseudogene 1 Homo sapiens 6-9 27558805-4 2016 Using NQO1 inhibition, over-expression and knock out, we have demonstrated that, in addition to protection of beta-cells from toxic concentrations of the redox cycling quinone menadione, NQO1 also regulates the basal level of reduced-to-oxidized nucleotides, suggesting other role(s) beside that of an antioxidant enzyme. quinone 168-175 NAD(P)H quinone dehydrogenase 1 Homo sapiens 187-191 28132436-2 2017 To explore the mechanism underlying this effect, we previously showed that the oxidation of RD with mushroom or human tyrosinase produces cytotoxic quinone oxidation products. quinone 148-155 tyrosinase Homo sapiens 118-128 27105286-7 2016 The data obtained and the already available information allowed systematizing several properties of NDH-2s: (i) the existence of additional sequence motifs with putative regulatory functions, (ii) specificity towards NADH or NADPH and (iii) the type of quinone binding motif. quinone 253-260 DExH-box helicase 9 Homo sapiens 100-105 27856348-5 2016 When glyceraldehyde 3-phosphate dehydrogenase was exposed to the myeloperoxidase system with 5HIAA, quinone adducts were formed on the protein molecule. quinone 100-107 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 5-45 27856348-5 2016 When glyceraldehyde 3-phosphate dehydrogenase was exposed to the myeloperoxidase system with 5HIAA, quinone adducts were formed on the protein molecule. quinone 100-107 myeloperoxidase Homo sapiens 65-80 27830641-5 2016 The central position of the active complex III monomer between complex I and IV in the respirasome is optimal for accepting reduced quinone from complex I over a short diffusion distance of 11 nm, and delivering reduced cytochrome c to complex IV. quinone 132-139 LOC104968582 Bos taurus 220-232 27824210-2 2016 VKORC1 catalyses the reduction of vitamin K 2,3-epoxide to the quinone form of vitamin K and further to vitamin K hydroquinone. quinone 63-70 vitamin K epoxide reductase complex subunit 1 Homo sapiens 0-6 27764794-2 2016 After screening a library of 2697 small molecule compounds, we found that two classes of compounds, the quinone-containing compounds such as nanaomycin and anti-microtubule drugs such as vincristine, exerted the best synergistic anticancer effects with the BET bromodomain inhibitor JQ1 in neuroblastoma cells. quinone 104-111 delta/notch like EGF repeat containing Homo sapiens 257-260 27764794-3 2016 Mechanistically, the quinone-containing compound nanaomycin induced neuroblastoma cell death but also activated the Nrf2-antioxidant signaling pathway, and the BET bromodomain proteins BRD3 and BRD4 formed a protein complex with Nrf2. quinone 21-28 nuclear factor, erythroid derived 2, like 2 Mus musculus 116-120 27764794-3 2016 Mechanistically, the quinone-containing compound nanaomycin induced neuroblastoma cell death but also activated the Nrf2-antioxidant signaling pathway, and the BET bromodomain proteins BRD3 and BRD4 formed a protein complex with Nrf2. quinone 21-28 delta/notch like EGF repeat containing Homo sapiens 160-163 27764794-3 2016 Mechanistically, the quinone-containing compound nanaomycin induced neuroblastoma cell death but also activated the Nrf2-antioxidant signaling pathway, and the BET bromodomain proteins BRD3 and BRD4 formed a protein complex with Nrf2. quinone 21-28 bromodomain containing 3 Mus musculus 185-189 27764794-3 2016 Mechanistically, the quinone-containing compound nanaomycin induced neuroblastoma cell death but also activated the Nrf2-antioxidant signaling pathway, and the BET bromodomain proteins BRD3 and BRD4 formed a protein complex with Nrf2. quinone 21-28 bromodomain containing 4 Mus musculus 194-198 27764794-3 2016 Mechanistically, the quinone-containing compound nanaomycin induced neuroblastoma cell death but also activated the Nrf2-antioxidant signaling pathway, and the BET bromodomain proteins BRD3 and BRD4 formed a protein complex with Nrf2. quinone 21-28 nuclear factor, erythroid derived 2, like 2 Mus musculus 229-233 27770821-0 2016 The 1,4 benzoquinone-featured 5-lipoxygenase inhibitor RF-Id induces apoptotic death through downregulation of IAPs in human glioblastoma cells. quinone 4-20 arachidonate 5-lipoxygenase Homo sapiens 30-44 26923841-5 2016 The results show that benzoquinone can efficiently quench the fluorescence of pyranine with dynamic quenching rate constants in the order of 1010 M-1 s-1 , suggesting that the pyranine can act as a good electron donor for photoinduced electron transfer in artificial photosynthesis and organic solar cells. quinone 22-34 tumor associated calcium signal transducer 2 Homo sapiens 146-153 27425441-0 2016 MiR-133a regarded as a potential biomarker for benzene toxicity through targeting Caspase-9 to inhibit apoptosis induced by benzene metabolite (1,4-Benzoquinone). quinone 144-160 caspase 9 Homo sapiens 82-91 27656164-0 2016 All Three Endogenous Quinone Species of Escherichia coli Are Involved in Controlling the Activity of the Aerobic/Anaerobic Response Regulator ArcA. quinone 21-28 arginine deiminase Escherichia coli 142-146 27561631-1 2016 A new strategy for the efficient synthesis of C-5 heterocyclyl substituted Coenzyme Q analogues was developed by N-alkylation of bromomethylated quinone 11 with a series of amines 12 under metal-free conditions. quinone 145-152 complement C5 Homo sapiens 46-49 27502282-5 2016 PA1024 could reduce a broad spectrum of quinone substrates via a Ping Pong Bi Bi steady-state kinetic mechanism, generating the corresponding hydroquinones. quinone 40-47 nitronate monooxygenase Pseudomonas aeruginosa PAO1 0-6 27656164-6 2016 In all three "single-quinone" E. coli strains transitions in the activity of ArcB are observed, as evidenced by changes in the level of phosphorylation of the response regulator ArcA, upon depletion/readmission of oxygen. quinone 21-28 hypothetical protein Escherichia coli 77-81 27656164-6 2016 In all three "single-quinone" E. coli strains transitions in the activity of ArcB are observed, as evidenced by changes in the level of phosphorylation of the response regulator ArcA, upon depletion/readmission of oxygen. quinone 21-28 arginine deiminase Escherichia coli 178-182 27251440-3 2016 In the present study, we found that an active, quinone-type PCB metabolite (PCB29-pQ) treatment causes an autophagic response through mTOR/p70S6k inhibition in HepG2 and MDA-MB-231 cells. quinone 47-54 mechanistic target of rapamycin kinase Homo sapiens 134-138 27430589-4 2016 Reaction of the oxidized GFA with p-dihydrobenzoquinone to give p-benzoquinone shows that typical proton-coupled electron-transfer reactions are also possible. quinone 64-78 glutamine--fructose-6-phosphate transaminase 1 Homo sapiens 25-28 26456483-10 2016 Benzoquinone exposure significantly decreased the transcript levels of the critical base excision repair gene, 8-oxoguanine glycosylase (Ogg1), which was not prevented by SFN. quinone 0-12 8-oxoguanine DNA-glycosylase 1 Mus musculus 137-141 27251440-3 2016 In the present study, we found that an active, quinone-type PCB metabolite (PCB29-pQ) treatment causes an autophagic response through mTOR/p70S6k inhibition in HepG2 and MDA-MB-231 cells. quinone 47-54 ribosomal protein S6 kinase B1 Homo sapiens 139-145 25952742-0 2016 Isolation and Cr(VI) reduction characteristics of quinone respiration in Mangrovibacter plantisponsor strain CR1. quinone 50-57 complement C3b/C4b receptor 1 (Knops blood group) Homo sapiens 109-112 27508986-2 2016 The analogue, H2B-Q, consists of the redox-active quinone segment found in ubiquinone, 2,3-dimethoxy-1,4-benzoquinone, coupled to a boron-dipyrromethene (BODIPY) fluorophore segment that both imparts lipophilicity in lieu of the isoprenyl tail of ubiquinone, and reports on redox changes at the quinone/quinol segment. quinone 50-57 H2B clustered histone 21 Homo sapiens 14-19 27508986-2 2016 The analogue, H2B-Q, consists of the redox-active quinone segment found in ubiquinone, 2,3-dimethoxy-1,4-benzoquinone, coupled to a boron-dipyrromethene (BODIPY) fluorophore segment that both imparts lipophilicity in lieu of the isoprenyl tail of ubiquinone, and reports on redox changes at the quinone/quinol segment. quinone 78-85 H2B clustered histone 21 Homo sapiens 14-19 27508986-4 2016 In its reduced dihydroquinone form, H2B-QH2 is highly emissive in nonpolar media (quantum yields 55-66%), while once oxidized, the resulting quinone H2B-Q emission is suppressed. quinone 22-29 H2B clustered histone 21 Homo sapiens 36-41 25952742-1 2016 A Cr(VI)-reducing Mangrovibacter plantisponsor strain, CR1, was isolated from tannery effluent sludge and had quinone respiration characteristics. quinone 110-117 complement C3b/C4b receptor 1 (Knops blood group) Homo sapiens 55-58 25952742-3 2016 Strain CR1 exhibited a high Cr(VI) resistance with a minimal inhibitory concentration (MIC) of 32 mM in LB medium, and its quinone respiration could occur when an electron donor and strain CR1 both existed in the reaction system. quinone 123-130 complement C3b/C4b receptor 1 (Knops blood group) Homo sapiens 7-10 25952742-3 2016 Strain CR1 exhibited a high Cr(VI) resistance with a minimal inhibitory concentration (MIC) of 32 mM in LB medium, and its quinone respiration could occur when an electron donor and strain CR1 both existed in the reaction system. quinone 123-130 complement C3b/C4b receptor 1 (Knops blood group) Homo sapiens 189-192 25952742-4 2016 Cr(VI) reduction by strain CR1 was significantly enhanced by a factor of 0.4-4.3 with five different quinone compounds: anthraquinone-2,7-disulfonate, anthraquinone-1-sulfonate, anthraquinone-2-sulfonate (AQS), anthraquinone-2,6-disulfonate, and anthraquinone-1,5-disulfonate. quinone 101-108 complement C3b/C4b receptor 1 (Knops blood group) Homo sapiens 27-30 27054409-6 2016 O-Monomethyl-O-monosulfonated-6-EC-catechol, its monohydroxy products, and N-acetyl-l-cysteine(NAC)-6-EC-ortho-quinone were discovered as signature metabolites of the ortho-quinone pathway. quinone 111-118 X-linked Kx blood group Homo sapiens 95-98 26808919-2 2016 Specifically, in all of biology, the quinone-binding subunit of Complex I, NuoD, is most closely related to the proton-reducing, H2-evolving [NiFe]-containing catalytic subunit, MbhL, of membrane-bound hydrogenase (MBH), to the methanophenzine-reducing subunit of a methanogenic respiratory complex (FPO) and to the catalytic subunit of an archaeal respiratory complex (MBX) involved in reducing elemental sulfur (S ). quinone 37-44 diencephalon/mesencephalon homeobox 1 Homo sapiens 370-373 27135737-3 2016 Enzyme-triggered theranostic prodrug 1 selectively targets cancer cells and is subsequently activated in the presence of NAD(P)H: quinone oxidoreductase-1 (NQO1), a cytosolic flavoprotein that catalyzes the two-electron reduction of quinone moieties with the concomitant consumption of NADH or NADPH as electron donors. quinone 130-137 NAD(P)H quinone dehydrogenase 1 Homo sapiens 156-160 27271875-4 2016 The gate opening and controlled release of the cargo are triggered by cleavage of the benzoquinone stopper using an endogenous NQO1 enzyme. quinone 86-98 NAD(P)H quinone dehydrogenase 1 Homo sapiens 127-131 27109346-3 2016 PPO mediated protein-quinone binding has been linked to protecting plant proteins from proteolysis. quinone 21-28 protoporphyrinogen oxidase Bos taurus 0-3 27340773-5 2016 BQ-induced damage efficiently stalls replication forks, yet poorly induces ATR/DNA-PKCS responses. quinone 0-2 protein kinase, DNA-activated, catalytic subunit Homo sapiens 79-87 27340773-6 2016 Furthermore, the pattern of BQ-induced gammaH2AX and 53BP1foci is consistent with the formation of poly(ADP-ribose) polymerase 1 (PARP1)-stabilized regressed replication forks. quinone 28-30 poly(ADP-ribose) polymerase 1 Homo sapiens 99-128 27340773-6 2016 Furthermore, the pattern of BQ-induced gammaH2AX and 53BP1foci is consistent with the formation of poly(ADP-ribose) polymerase 1 (PARP1)-stabilized regressed replication forks. quinone 28-30 poly(ADP-ribose) polymerase 1 Homo sapiens 130-135 26847926-2 2016 We have examined how forced expression of the NAD(P)H quinone dehydrogenase, quinone 1 (NQO1), a major quinone-reducing enzyme in cytosol, affects the survival of RD-treated cells. quinone 54-61 NAD(P)H quinone dehydrogenase 1 Homo sapiens 77-86 26847926-2 2016 We have examined how forced expression of the NAD(P)H quinone dehydrogenase, quinone 1 (NQO1), a major quinone-reducing enzyme in cytosol, affects the survival of RD-treated cells. quinone 54-61 NAD(P)H quinone dehydrogenase 1 Homo sapiens 88-92 26998531-0 2016 A quinone mediator drives oxidations catalysed by alcohol dehydrogenase-containing cell lysates. quinone 2-9 Alcohol dehydrogenase Escherichia coli 50-71 27070533-10 2016 Also unforeseen was the inhibitors" mechanism of action against TrxR, which was found to be brokered through a suicide-mechanism utilizing quinone methide as the inactivating element. quinone 139-146 peroxiredoxin 5 Homo sapiens 64-68 26998531-1 2016 Spontaneous electron transport to molecular oxygen led to regeneration of oxidised nicotinamide cofactor in cell lysates that contain an alcohol dehydrogenase, a quinone reductase and a quinone mediator. quinone 162-169 Alcohol dehydrogenase Escherichia coli 137-158 26998531-2 2016 This concept allows the efficient oxidation of alcohols in the presence of alcohol dehydrogenase-containing E. coli lysates and catalytic amounts of the quinone lawsone. quinone 153-160 Alcohol dehydrogenase Escherichia coli 75-96 26687450-8 2016 Using different breast cell models, we found that NQO1 overexpression was a main determinant for a potential chemotherapy resistance or an increased sensitivity to quinone-bearing compounds. quinone 164-171 NAD(P)H quinone dehydrogenase 1 Homo sapiens 50-54 26446353-3 2016 In this work, we propose a different interpretation of redox heterogeneity in the native population of Cyt b559 assuming redox interaction between the Cyt b559 heme group and a nearby bound quinone (Q). quinone 190-197 mitochondrially encoded cytochrome b Homo sapiens 103-108 26062463-14 2016 These data provide evidence that the covalent binding of PCB quinone metabolites to cytochrome c may be included among the toxic effects of PCBs. quinone 61-68 pyruvate carboxylase Homo sapiens 57-60 26062463-14 2016 These data provide evidence that the covalent binding of PCB quinone metabolites to cytochrome c may be included among the toxic effects of PCBs. quinone 61-68 cytochrome c, somatic Homo sapiens 84-96 26444488-6 2016 AO7 decomposition intermediates were analyzed by UV-vis spectrometry and GC-MS; 2-naphthol, 1,4-benzoquinone, phthalic anhydride, coumarin, 1,2-naphthoquinone, and 2-formyl-benzoic acid were detected. quinone 92-108 ring finger protein 25 Homo sapiens 0-3 26894873-5 2016 One of the compounds [3,6-dihydroxy-2-propylbenzaldehyde (GE-1)] is a hydroquinone, and the other [2-hydroxymethyl-3-propylcyclohexa-2,5-diene-1,4-dione (GE-2)] is a quinone. quinone 75-82 enhancer of mRNA decapping 4 Homo sapiens 58-62 26805846-4 2016 The tyrosinase target can catalyze the oxidization of tyrosine by oxygen into ortho-benzoquinone residues, which results in a decrease in the sensor photocurrent. quinone 84-96 tyrosinase Homo sapiens 4-14 26687450-10 2016 Thus, the NQO1 gene copy number and NQO1 activity should be considered when quinone-bearing molecules are being utilized as potential drugs against breast tumors. quinone 76-83 NAD(P)H quinone dehydrogenase 1 Homo sapiens 10-14 26687450-10 2016 Thus, the NQO1 gene copy number and NQO1 activity should be considered when quinone-bearing molecules are being utilized as potential drugs against breast tumors. quinone 76-83 NAD(P)H quinone dehydrogenase 1 Homo sapiens 36-40 25224400-2 2015 NAD(P)H: quinone oxidoreductase 1 (NQO1) is an important enzyme for detoxification, because it catabolizes endogenous/exogenous quinone to hydroquinone. quinone 9-16 NAD(P)H dehydrogenase, quinone 1 Mus musculus 35-39 26779013-7 2015 In addition, 5-Aza-mediated upregulation of Nrf2 expression was concomitant with increased nuclear translocation of Nrf2 and higher expression of Nrf2 downstream target gene NAD(P)H: quinone oxidoreductas (NQO1). quinone 183-190 NFE2 like bZIP transcription factor 2 Homo sapiens 44-48 26779013-7 2015 In addition, 5-Aza-mediated upregulation of Nrf2 expression was concomitant with increased nuclear translocation of Nrf2 and higher expression of Nrf2 downstream target gene NAD(P)H: quinone oxidoreductas (NQO1). quinone 183-190 NAD(P)H quinone dehydrogenase 1 Homo sapiens 206-210 27656260-0 2016 Inhibition of Glucose-6-Phosphate Dehydrogenase Could Enhance 1,4-Benzoquinone-Induced Oxidative Damage in K562 Cells. quinone 62-78 glucose-6-phosphate dehydrogenase Homo sapiens 14-47 27656260-4 2016 This study aims to investigate whether the downregulation of G6PD in K562 cell line can influence the oxidative toxicity induced by 1,4-benzoquinone (BQ). quinone 132-148 glucose-6-phosphate dehydrogenase Homo sapiens 61-65 27656260-4 2016 This study aims to investigate whether the downregulation of G6PD in K562 cell line can influence the oxidative toxicity induced by 1,4-benzoquinone (BQ). quinone 150-152 glucose-6-phosphate dehydrogenase Homo sapiens 61-65 27656260-7 2016 Results revealed that G6PD was significantly upregulated in the control cells and in the cells with inhibited G6PD after they were exposed to BQ. quinone 142-144 glucose-6-phosphate dehydrogenase Homo sapiens 22-26 27656260-7 2016 Results revealed that G6PD was significantly upregulated in the control cells and in the cells with inhibited G6PD after they were exposed to BQ. quinone 142-144 glucose-6-phosphate dehydrogenase Homo sapiens 110-114 27656260-8 2016 The NADPH/NADP and GSH/GSSG ratio were significantly lower in the cells with inhibited G6PD than in the control cells at the same BQ concentration. quinone 130-132 glucose-6-phosphate dehydrogenase Homo sapiens 87-91 26558468-3 2015 However, quinone species produced from mono- and bi-aromatic hydrocarbons could potentially cause AhR activation. quinone 9-16 aryl-hydrocarbon receptor Mus musculus 98-101 26558468-7 2015 Cyp1a1 induction mediated by 1,2-naphthoquinone (1,2-NQ), 1,4-NQ, 1,4-benzoquinone (1,4-BQ) and tert-butyl-1,4-BQ was suppressed by a specific AhR inhibitor and was not observed in c35 cells, which do not have a functional AhR. quinone 66-82 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 0-6 26558468-7 2015 Cyp1a1 induction mediated by 1,2-naphthoquinone (1,2-NQ), 1,4-NQ, 1,4-benzoquinone (1,4-BQ) and tert-butyl-1,4-BQ was suppressed by a specific AhR inhibitor and was not observed in c35 cells, which do not have a functional AhR. quinone 84-90 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 0-6 27458036-6 2016 XOR has an activating role that is essential to the pharmacological action of quinone drugs, cyadox, antiviral nucleoside analogues, allopurinol, nitrate and nitrite. quinone 78-85 xanthine dehydrogenase Homo sapiens 0-3 27025485-1 2016 A model of heme-quinone redox interaction has been developed for cytochrome b559 in photosystem II. quinone 16-23 mitochondrially encoded cytochrome b Homo sapiens 65-77 27853106-0 2016 Quinone-mediated induction of cytochrome P450 1A1 in HepG2 cells through increased interaction of aryl hydrocarbon receptor with aryl hydrocarbon receptor nuclear translocator. quinone 0-7 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 30-49 27853106-0 2016 Quinone-mediated induction of cytochrome P450 1A1 in HepG2 cells through increased interaction of aryl hydrocarbon receptor with aryl hydrocarbon receptor nuclear translocator. quinone 0-7 aryl hydrocarbon receptor Homo sapiens 98-123 27853106-0 2016 Quinone-mediated induction of cytochrome P450 1A1 in HepG2 cells through increased interaction of aryl hydrocarbon receptor with aryl hydrocarbon receptor nuclear translocator. quinone 0-7 aryl hydrocarbon receptor Homo sapiens 129-154 26424559-1 2015 NAD(P)H: quinone oxidoreductase (NQO1), an obligatory two-electron reductase, is a ubiquitous cytosolic enzyme that catalyzes the reduction of quinone substrates. quinone 9-16 NAD(P)H quinone dehydrogenase 1 Homo sapiens 33-37 26424559-5 2015 On the other hand, NQO1-mediated two-electron reduction converts certain quinone compounds (such as mitomycin C, E09, RH1 and -lapachone) to cytotoxic agents, leading to cell death. quinone 73-80 NAD(P)H quinone dehydrogenase 1 Homo sapiens 19-23 26450473-3 2015 Tyrosinase hydroxylates the oxyresveratrol to an o-diphenol and oxidizes the latter to an o-quinone, which finally isomerizes to p-quinone. quinone 129-138 tyrosinase Homo sapiens 0-10 26474287-7 2015 Interestingly, triterpenoid derivatives lacking the quinone methide showed enhanced specificity and potency against Myc. quinone 52-59 MYC proto-oncogene, bHLH transcription factor Homo sapiens 116-119 25612170-0 2015 Cytotoxicity of luteolin in primary rat hepatocytes: the role of CYP3A-mediated ortho-benzoquinone metabolite formation and glutathione depletion. quinone 86-98 cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus 65-70 26136433-6 2015 The inclusion of benzoquinone (BQ) equidistant between the TiO2 and CdS through DNA assembly further increased H2 production. quinone 17-29 CDP-diacylglycerol synthase 1 Homo sapiens 68-71 26136433-6 2015 The inclusion of benzoquinone (BQ) equidistant between the TiO2 and CdS through DNA assembly further increased H2 production. quinone 31-33 CDP-diacylglycerol synthase 1 Homo sapiens 68-71 25289770-12 2015 The data provides evidence for the first time that autophagy and AKR1B10 contribute to the defense system against the cytotoxicity caused by the electrophilic p-quinone metabolites of BHQ. quinone 159-168 aldo-keto reductase family 1 member B10 Homo sapiens 65-72 26622336-0 2015 Biological effects of pyrroloquinoline quinone on liver damage in Bmi-1 knockout mice. quinone 39-46 Bmi1 polycomb ring finger oncogene Mus musculus 66-71 26075484-7 2015 The result revealed the quinone usage as the secondary electron acceptor in hRC, as in the case of PS I. quinone 24-31 histidine rich calcium binding protein Homo sapiens 76-79 25569871-1 2015 We report a label-free aptasensor to make direct detection of prostate specific antigen (PSA, a biomarker of prostate cancer) using a quinone-containing conducting copolymer acting as redox transducer and grafting matrix for immobilization of the short aptamer strands. quinone 134-141 kallikrein related peptidase 3 Homo sapiens 62-87 25569871-1 2015 We report a label-free aptasensor to make direct detection of prostate specific antigen (PSA, a biomarker of prostate cancer) using a quinone-containing conducting copolymer acting as redox transducer and grafting matrix for immobilization of the short aptamer strands. quinone 134-141 kallikrein related peptidase 3 Homo sapiens 89-92 26540617-0 2015 Quinone-Modified Mn-Doped ZnS Quantum Dots for Room-Temperature Phosphorescence Sensing of Human Cancer Cells That Overexpress NQO1. quinone 0-7 NAD(P)H quinone dehydrogenase 1 Homo sapiens 127-131 26005900-3 2015 Highly selective and rapid activation of the quinone group by the human cancer tumor-linked NAD(P)H: quinone oxido-reductase isozyme 1 (hNQO1) results in fast trigger group removal to yield a highly fluorescent green-energy-range reporter that possesses a high molar absorptivity; there is a 136-fold increase in brightness for the enzymatically produced reporter versus probe precursor, a value 4 times greater than previously reported for the hNQO1 analyte. quinone 45-52 NAD(P)H quinone dehydrogenase 1 Homo sapiens 136-141 26005900-3 2015 Highly selective and rapid activation of the quinone group by the human cancer tumor-linked NAD(P)H: quinone oxido-reductase isozyme 1 (hNQO1) results in fast trigger group removal to yield a highly fluorescent green-energy-range reporter that possesses a high molar absorptivity; there is a 136-fold increase in brightness for the enzymatically produced reporter versus probe precursor, a value 4 times greater than previously reported for the hNQO1 analyte. quinone 45-52 NAD(P)H quinone dehydrogenase 1 Homo sapiens 445-450 25264100-2 2015 Various mutations in the quinone binding site of the cytochrome b gene of Plasmodium spp. quinone 25-32 CYTB Plasmodium falciparum 53-65 28962422-0 2015 1,4-benzoquinone-induced STAT-3 hypomethylation in AHH-1 cells: Role of oxidative stress. quinone 0-16 signal transducer and activator of transcription 3 Homo sapiens 25-31 28962422-8 2015 Results indicated the significantly increasing expression of ROS and 8-OHdG which accompanied with STAT3 hypomethylation in 1,4-BQ-treated AHH-1 cells. quinone 124-130 signal transducer and activator of transcription 3 Homo sapiens 99-104 28962422-9 2015 alpha-LA suppressed the expression of both ROS and 8-OHdG, simultaneously reversed 1,4-BQ-induced STAT3 hypomethylation. quinone 83-89 signal transducer and activator of transcription 3 Homo sapiens 98-103 28962422-11 2015 Taken together, oxidative stress are involved 1,4-BQ-induced STAT3 methylation expression. quinone 46-52 signal transducer and activator of transcription 3 Homo sapiens 61-66 25264100-10 2015 The findings indicate the importance of the mutation in the quinone binding site of the cytochrome b gene and that provide a direct evidence for the atovaquone inhibitory mechanism in the cytochrome bc1 complex of the parasite. quinone 60-67 CYTB Plasmodium falciparum 88-100 26504962-3 2015 The results has shown that NAC participates in Michael type addition reaction with electrogenerated quinone from electrooxidation of 4-chlorocatechol at MWCNT/GCE to form the corresponding thioquinone derivative. quinone 100-107 X-linked Kx blood group Homo sapiens 27-30 25994234-2 2015 It has been hypothesized that CPs are cross-linked to other CPs and possibly to chitin by quinones or quinone methides produced by the laccase2-mediated oxidation of N-acylcatechols. quinone 90-97 laccase 2 Tribolium castaneum 135-143 26674599-2 2015 Geldanamycin (GA), a natural benzoquinone, can inhibit the chaperone activity of Hsp90. quinone 29-41 heat shock protein 90 alpha family class A member 1 Homo sapiens 81-86 25713930-2 2015 To explore the mechanism underlying that effect, we previously showed that oxidation of RD with mushroom tyrosinase produces RD-quinone, which is converted to secondary quinone products, and we suggested that those quinones are cytotoxic because they bind to cellular proteins and produce reactive oxygen species. quinone 128-135 tyrosinase Homo sapiens 105-115 25465992-4 2015 In the non-irradiated samples, PAL activity increased as a consequence of up-regulation of PAL gene expression after 24 and 48 h by 1.2 and 7.7-fold, respectively, during storage that could be linearly correlated with enhanced quinone formation and browning. quinone 227-234 phenylalanine ammonia-lyase 1 Brassica oleracea 31-34 25465992-4 2015 In the non-irradiated samples, PAL activity increased as a consequence of up-regulation of PAL gene expression after 24 and 48 h by 1.2 and 7.7-fold, respectively, during storage that could be linearly correlated with enhanced quinone formation and browning. quinone 227-234 phenylalanine ammonia-lyase 1 Brassica oleracea 91-94 25023609-0 2015 Inhibition of the HIF1alpha-p300 interaction by quinone- and indandione-mediated ejection of structural Zn(II). quinone 48-55 hypoxia inducible factor 1 subunit alpha Homo sapiens 18-27 25023609-0 2015 Inhibition of the HIF1alpha-p300 interaction by quinone- and indandione-mediated ejection of structural Zn(II). quinone 48-55 E1A binding protein p300 Homo sapiens 28-32 25023609-2 2015 A natural product based screen led to the identification of indandione and benzoquinone derivatives that reduce the tight interaction between a HIF-1alpha fragment and the CH1 domain of p300. quinone 75-87 hypoxia inducible factor 1 subunit alpha Homo sapiens 144-154 25023609-2 2015 A natural product based screen led to the identification of indandione and benzoquinone derivatives that reduce the tight interaction between a HIF-1alpha fragment and the CH1 domain of p300. quinone 75-87 E1A binding protein p300 Homo sapiens 186-190 25671648-5 2015 The dual concept quinone/cannabinoid was supported by the fact that compound 10 exerts antitumor effect by inducing cell apoptosis through activation of CB2 receptors and through oxidative stress. quinone 17-24 cannabinoid receptor 2 Homo sapiens 153-156 25645895-9 2015 Exposure to 1,4-BQ showed no significant effect on CD3e(+) cells but reduced the total counts of Sca-1(+), CD11b(+), Gr-1(+), and CD45(+) cells at 7 and 12 muM (p < 0.05). quinone 12-18 ataxin 1 Homo sapiens 97-102 25645895-9 2015 Exposure to 1,4-BQ showed no significant effect on CD3e(+) cells but reduced the total counts of Sca-1(+), CD11b(+), Gr-1(+), and CD45(+) cells at 7 and 12 muM (p < 0.05). quinone 12-18 integrin subunit alpha M Homo sapiens 107-112 25645895-9 2015 Exposure to 1,4-BQ showed no significant effect on CD3e(+) cells but reduced the total counts of Sca-1(+), CD11b(+), Gr-1(+), and CD45(+) cells at 7 and 12 muM (p < 0.05). quinone 12-18 glutathione reductase Mus musculus 117-121 25645895-9 2015 Exposure to 1,4-BQ showed no significant effect on CD3e(+) cells but reduced the total counts of Sca-1(+), CD11b(+), Gr-1(+), and CD45(+) cells at 7 and 12 muM (p < 0.05). quinone 12-18 protein tyrosine phosphatase receptor type C Homo sapiens 130-134 24958513-7 2015 The result of the catalytic activity of PGES is p-benzoquinone (PBQI) production. quinone 48-62 prostaglandin E synthase Homo sapiens 40-44 24958513-7 2015 The result of the catalytic activity of PGES is p-benzoquinone (PBQI) production. quinone 64-68 prostaglandin E synthase Homo sapiens 40-44 25677663-0 2015 Synthesis and evaluation of (+-)-dunnione and its ortho-quinone analogues as substrates for NAD(P)H:quinone oxidoreductase 1 (NQO1). quinone 56-63 NAD(P)H quinone dehydrogenase 1 Homo sapiens 92-124 25677663-0 2015 Synthesis and evaluation of (+-)-dunnione and its ortho-quinone analogues as substrates for NAD(P)H:quinone oxidoreductase 1 (NQO1). quinone 56-63 NAD(P)H quinone dehydrogenase 1 Homo sapiens 126-130 25677663-1 2015 Natural product (+-)-dunnione (2) and its ortho-quinone analogues (3-8) were synthesized and found to be substrates for NQO1. quinone 48-55 NAD(P)H quinone dehydrogenase 1 Homo sapiens 120-124 24155226-0 2015 A novel coumarin-quinone derivative SV37 inhibits CDC25 phosphatases, impairs proliferation, and induces cell death. quinone 17-24 cell division cycle 25C Homo sapiens 50-55 25572106-0 2015 New, non-quinone fluorogeldanamycin derivatives strongly inhibit Hsp90. quinone 9-16 heat shock protein 90 alpha family class A member 1 Homo sapiens 65-70 25668752-9 2015 These later efforts have led to the discovery of a uniquely selective benzoquinone ansamycin-inspired Hsp90 inhibitor that lacks the problematic quinone present in the natural series. quinone 75-82 heat shock protein 90 alpha family class A member 1 Homo sapiens 102-107 25668756-0 2015 Ligand-independent activation of aryl hydrocarbon receptor signaling in PCB3-quinone treated HaCaT human keratinocytes. quinone 77-84 aryl hydrocarbon receptor Homo sapiens 33-58 25668756-0 2015 Ligand-independent activation of aryl hydrocarbon receptor signaling in PCB3-quinone treated HaCaT human keratinocytes. quinone 77-84 pyruvate carboxylase Homo sapiens 72-76 25668756-3 2015 Results from this study show that a quinone-derivative (1-(4-Chlorophenyl)-benzo-2,5-quinone; 4-ClBQ) of a non-dioxin like PCB (PCB3) also activates AhR-signaling. quinone 36-43 pyruvate carboxylase Homo sapiens 123-126 25668756-3 2015 Results from this study show that a quinone-derivative (1-(4-Chlorophenyl)-benzo-2,5-quinone; 4-ClBQ) of a non-dioxin like PCB (PCB3) also activates AhR-signaling. quinone 36-43 pyruvate carboxylase Homo sapiens 128-132 25668756-3 2015 Results from this study show that a quinone-derivative (1-(4-Chlorophenyl)-benzo-2,5-quinone; 4-ClBQ) of a non-dioxin like PCB (PCB3) also activates AhR-signaling. quinone 36-43 aryl hydrocarbon receptor Homo sapiens 149-152 25692465-1 2015 UNLABELLED: beta-lapachone (beta-lap), an NAD(P)H: quinone oxidoreductase 1 (NQO1) targeting antitumor drug candidate in phase II clinical trials, is metabolically eliminated via NQO1 mediated quinone reduction and subsequent UDP-glucuronosyltransferases (UGTs) catalyzed glucuronidation. quinone 51-58 NAD(P)H quinone dehydrogenase 1 Homo sapiens 77-81 25692465-1 2015 UNLABELLED: beta-lapachone (beta-lap), an NAD(P)H: quinone oxidoreductase 1 (NQO1) targeting antitumor drug candidate in phase II clinical trials, is metabolically eliminated via NQO1 mediated quinone reduction and subsequent UDP-glucuronosyltransferases (UGTs) catalyzed glucuronidation. quinone 51-58 NAD(P)H quinone dehydrogenase 1 Homo sapiens 179-183 25494338-2 2015 It has been shown that by the proper choice of a linker group bridging the quinone rings and substituents in the diketonate fragments, complexes with the properties required in 2-qubit quantum gates (sufficiently narrow energy gaps between the spin states and weakly coupled paramagnetic centers) can be designed, in order to realize the mechanism of thermally driven migration of paramagnetic centers between the o-quinone fragments and metal atoms. quinone 75-82 spindlin 1 Homo sapiens 244-248 25477506-0 2015 The quinone methide aurin is a heat shock response inducer that causes proteotoxic stress and Noxa-dependent apoptosis in malignant melanoma cells. quinone 4-11 phorbol-12-myristate-13-acetate-induced protein 1 Homo sapiens 94-98 25846630-0 2015 Removal of bisphenol derivatives through quinone oxidation by polyphenol oxidase and subsequent quinone adsorption on chitosan in the heterogeneous system. quinone 41-48 protoporphyrinogen oxidase Homo sapiens 62-80 25846630-2 2015 The process parameters, such as the pH value, temperature, and PPO concentration, were estimated to conduct the enzymatic quinone oxidation of bisphenol derivatives by as little enzyme as possible. quinone 122-129 protoporphyrinogen oxidase Homo sapiens 63-66 25451576-0 2014 Demethylation of neferine in human liver microsomes and formation of quinone methide metabolites mediated by CYP3A4 accentuates its cytotoxicity. quinone 69-76 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 109-115 25910742-2 2015 Branching from the traditional respiratory chain at the quinone pool, AOX is responsible for cyanide-resistant respiration in plants and fungi, heat generation in thermogenic plants, and survival of parasites, such as Trypanosoma brucei, in the human host. quinone 56-63 acyl-CoA oxidase 1 Homo sapiens 70-73 25540143-0 2015 Electronic connection between the quinone and cytochrome C redox pools and its role in regulation of mitochondrial electron transport and redox signaling. quinone 34-41 cytochrome c, somatic Homo sapiens 46-58 25540143-2 2015 One of the mitochondrial complexes, complex III (cytochrome bc1 or ubiquinol:cytochrome c oxidoreductase), provides an electronic connection between these two diffusible redox pools linking in a fully reversible manner two-electron quinone oxidation/reduction with one-electron cytochrome c reduction/oxidation. quinone 232-239 cytochrome c, somatic Homo sapiens 77-89 25540143-2 2015 One of the mitochondrial complexes, complex III (cytochrome bc1 or ubiquinol:cytochrome c oxidoreductase), provides an electronic connection between these two diffusible redox pools linking in a fully reversible manner two-electron quinone oxidation/reduction with one-electron cytochrome c reduction/oxidation. quinone 232-239 cytochrome c, somatic Homo sapiens 278-290 25437431-0 2014 Regulation of PKM2 and Nrf2-ARE pathway during benzoquinone induced oxidative stress in yolk sac hematopoietic stem cells. quinone 47-59 pyruvate kinase M1/2 Homo sapiens 14-18 25771868-8 2014 Ascorbic acid, a reducing and free radical-scavenging agent, significantly lowered the effects of hydroquinone, catechol, trihydroxybenzene as well as N-nitrosodimethylamine (a known CYP2E1-dependent promutagen), with that of benzoquinone unaffected. quinone 226-238 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 183-189 25876968-0 2015 [Inhibitors of DNA-dependent protein kinase promote p53-independent apoptosis induced by 1, 4-benzoquinone in HL60 cells]. quinone 89-106 protein kinase, DNA-activated, catalytic subunit Homo sapiens 15-43 25876968-0 2015 [Inhibitors of DNA-dependent protein kinase promote p53-independent apoptosis induced by 1, 4-benzoquinone in HL60 cells]. quinone 89-106 tumor protein p53 Homo sapiens 52-55 25876968-1 2015 OBJECTIVE: To investigate the impact of NU7026 and Wortmannin, inhibitors of DNA-dependent protein kinase (DNA-PK), in HL60 cells apoptosis induced by 1, 4-benzoquinone (1, 4-BQ). quinone 151-168 protein kinase, DNA-activated, catalytic subunit Homo sapiens 77-105 25876968-1 2015 OBJECTIVE: To investigate the impact of NU7026 and Wortmannin, inhibitors of DNA-dependent protein kinase (DNA-PK), in HL60 cells apoptosis induced by 1, 4-benzoquinone (1, 4-BQ). quinone 151-168 protein kinase, DNA-activated, catalytic subunit Homo sapiens 107-113 25876968-11 2015 In addition, both NU7026 and Wortmannin pretreatment elicited the higher expression of Bax mRNA in HL60 treated by 1, 4-benzoquinone with statistically significance (P < 0.05). quinone 115-132 BCL2 associated X, apoptosis regulator Homo sapiens 87-90 25876968-13 2015 CONCLUSION: Inhibitors of DNA-PK, NU7026 and Wortmannin, promote p53-independent apoptosis induced by 1, 4-benzoquinone in HL60 cells. quinone 102-119 protein kinase, DNA-activated, catalytic subunit Homo sapiens 26-32 25876968-13 2015 CONCLUSION: Inhibitors of DNA-PK, NU7026 and Wortmannin, promote p53-independent apoptosis induced by 1, 4-benzoquinone in HL60 cells. quinone 102-119 tumor protein p53 Homo sapiens 65-68 25339443-1 2014 Coenzyme Q (CoQ) is an isoprenylated quinone that is essential for cellular respiration and is synthesized in mitochondria by the combined action of at least nine proteins (COQ1-9). quinone 37-44 decaprenyl diphosphate synthase subunit 1 Homo sapiens 173-179 25189838-4 2014 Quinone derivatives enzymatically generated were chemisorbed on chitosan beads and the initial velocity of PPO-catalysed oxidation increased with an increase in the amount of added chitosan beads. quinone 0-7 protoporphyrinogen oxidase Homo sapiens 107-110 25437431-0 2014 Regulation of PKM2 and Nrf2-ARE pathway during benzoquinone induced oxidative stress in yolk sac hematopoietic stem cells. quinone 47-59 NFE2 like bZIP transcription factor 2 Homo sapiens 23-27 25437431-3 2014 In the present report, we investigated the effect of PKM2 and Nrf2-ARE pathway on the cellular antioxidant response to oxidative stress induced by benzene metabolite benzoquinone (BQ) in YS-HSC isolated from embryonic yolk sac and enriched by magnetic-activated cell sorting (MACS). quinone 166-178 pyruvate kinase M1/2 Homo sapiens 53-57 25437431-3 2014 In the present report, we investigated the effect of PKM2 and Nrf2-ARE pathway on the cellular antioxidant response to oxidative stress induced by benzene metabolite benzoquinone (BQ) in YS-HSC isolated from embryonic yolk sac and enriched by magnetic-activated cell sorting (MACS). quinone 166-178 NFE2 like bZIP transcription factor 2 Homo sapiens 62-66 25437431-3 2014 In the present report, we investigated the effect of PKM2 and Nrf2-ARE pathway on the cellular antioxidant response to oxidative stress induced by benzene metabolite benzoquinone (BQ) in YS-HSC isolated from embryonic yolk sac and enriched by magnetic-activated cell sorting (MACS). quinone 180-182 pyruvate kinase M1/2 Homo sapiens 53-57 25437431-3 2014 In the present report, we investigated the effect of PKM2 and Nrf2-ARE pathway on the cellular antioxidant response to oxidative stress induced by benzene metabolite benzoquinone (BQ) in YS-HSC isolated from embryonic yolk sac and enriched by magnetic-activated cell sorting (MACS). quinone 180-182 NFE2 like bZIP transcription factor 2 Homo sapiens 62-66 25437431-5 2014 Additional tests showed that BQ is also capable of inducing expression of NADPH oxidase1 (NOX1), and several other antioxidant enzymes or drug-metabolizing enzymes, including heme oxygenase 1 (HMOX1), superoxide dismutase (SOD), catalase and NAD(P)H dehydrogenase quinone 1 (NQO1). quinone 29-31 NADPH oxidase 1 Homo sapiens 74-88 25437431-5 2014 Additional tests showed that BQ is also capable of inducing expression of NADPH oxidase1 (NOX1), and several other antioxidant enzymes or drug-metabolizing enzymes, including heme oxygenase 1 (HMOX1), superoxide dismutase (SOD), catalase and NAD(P)H dehydrogenase quinone 1 (NQO1). quinone 29-31 NADPH oxidase 1 Homo sapiens 90-94 25437431-5 2014 Additional tests showed that BQ is also capable of inducing expression of NADPH oxidase1 (NOX1), and several other antioxidant enzymes or drug-metabolizing enzymes, including heme oxygenase 1 (HMOX1), superoxide dismutase (SOD), catalase and NAD(P)H dehydrogenase quinone 1 (NQO1). quinone 29-31 heme oxygenase 1 Homo sapiens 175-191 25437431-5 2014 Additional tests showed that BQ is also capable of inducing expression of NADPH oxidase1 (NOX1), and several other antioxidant enzymes or drug-metabolizing enzymes, including heme oxygenase 1 (HMOX1), superoxide dismutase (SOD), catalase and NAD(P)H dehydrogenase quinone 1 (NQO1). quinone 29-31 heme oxygenase 1 Homo sapiens 193-198 25437431-5 2014 Additional tests showed that BQ is also capable of inducing expression of NADPH oxidase1 (NOX1), and several other antioxidant enzymes or drug-metabolizing enzymes, including heme oxygenase 1 (HMOX1), superoxide dismutase (SOD), catalase and NAD(P)H dehydrogenase quinone 1 (NQO1). quinone 29-31 catalase Homo sapiens 229-237 25437431-5 2014 Additional tests showed that BQ is also capable of inducing expression of NADPH oxidase1 (NOX1), and several other antioxidant enzymes or drug-metabolizing enzymes, including heme oxygenase 1 (HMOX1), superoxide dismutase (SOD), catalase and NAD(P)H dehydrogenase quinone 1 (NQO1). quinone 29-31 NAD(P)H quinone dehydrogenase 1 Homo sapiens 242-273 25437431-5 2014 Additional tests showed that BQ is also capable of inducing expression of NADPH oxidase1 (NOX1), and several other antioxidant enzymes or drug-metabolizing enzymes, including heme oxygenase 1 (HMOX1), superoxide dismutase (SOD), catalase and NAD(P)H dehydrogenase quinone 1 (NQO1). quinone 29-31 NAD(P)H quinone dehydrogenase 1 Homo sapiens 275-279 25437431-7 2014 Pretreatment of the cells with antioxidant N-acetylcysteine (NAC) decreased ROS generation and prevented BQ-induced PKM2 degradation, suggesting involvement of ROS in the PKM2 protein degradation in cellular response to BQ. quinone 105-107 pyruvate kinase M1/2 Homo sapiens 116-120 25437431-7 2014 Pretreatment of the cells with antioxidant N-acetylcysteine (NAC) decreased ROS generation and prevented BQ-induced PKM2 degradation, suggesting involvement of ROS in the PKM2 protein degradation in cellular response to BQ. quinone 105-107 pyruvate kinase M1/2 Homo sapiens 171-175 25437431-7 2014 Pretreatment of the cells with antioxidant N-acetylcysteine (NAC) decreased ROS generation and prevented BQ-induced PKM2 degradation, suggesting involvement of ROS in the PKM2 protein degradation in cellular response to BQ. quinone 220-222 pyruvate kinase M1/2 Homo sapiens 171-175 24708242-5 2014 SRY up-regulation occurred via the p-quinone pathway, associated with a 3.5-fold increase in expression of GADD45gamma, a DNA damage inducible factor gene and known SRY regulator. quinone 37-44 growth arrest and DNA damage inducible gamma Homo sapiens 107-118 25162298-2 2014 At low activities, the diphenol was oxidatively chemisorbed as benzoquinone in a flat orientation, suggestive of a Pd(2,3,5,6-eta-C6H4O2) surface complex; at higher concentrations, vertical chemisorption was effected via two C-H bond activations (or metalations) at the 2 and 3 ring positions, evocative of an o-phenylene organopalladium compound. quinone 63-75 endothelin receptor type A Homo sapiens 126-129 25162298-5 2014 The DFT results suggested that, for the flat structure, surface coordination is via the two double bonds of the quinone ring as in [Pd(2,3,5,6-eta)-2,3-dimethyl-p-quinone]. quinone 112-119 endothelin receptor type A Homo sapiens 143-146 25143260-1 2014 UNLABELLED: Human NAD(P)H: quinone oxidoreductase 1 (NQO1) is essential for the antioxidant defense system, stabilization of tumor suppressors (e.g. p53, p33, and p73), and activation of quinone-based chemotherapeutics. quinone 27-34 NAD(P)H quinone dehydrogenase 1 Homo sapiens 53-57 25143260-1 2014 UNLABELLED: Human NAD(P)H: quinone oxidoreductase 1 (NQO1) is essential for the antioxidant defense system, stabilization of tumor suppressors (e.g. p53, p33, and p73), and activation of quinone-based chemotherapeutics. quinone 27-34 tumor protein p53 Homo sapiens 149-152 25143260-1 2014 UNLABELLED: Human NAD(P)H: quinone oxidoreductase 1 (NQO1) is essential for the antioxidant defense system, stabilization of tumor suppressors (e.g. p53, p33, and p73), and activation of quinone-based chemotherapeutics. quinone 27-34 inhibitor of growth family member 1 Homo sapiens 154-157 25143260-1 2014 UNLABELLED: Human NAD(P)H: quinone oxidoreductase 1 (NQO1) is essential for the antioxidant defense system, stabilization of tumor suppressors (e.g. p53, p33, and p73), and activation of quinone-based chemotherapeutics. quinone 27-34 tumor protein p73 Homo sapiens 163-166 25143260-2 2014 Overexpression of NQO1 in many solid tumors, coupled with its ability to convert quinone-based chemotherapeutics into potent cytotoxic compounds, have made it a very attractive target for anticancer drugs. quinone 81-88 NAD(P)H quinone dehydrogenase 1 Homo sapiens 18-22 25027801-3 2014 Replacement of the quinone moiety of RDA with a phenyl ring (2) was found to be better suited for Grp94 inhibition as it can fully interact with a unique hydrophobic pocket present in Grp94. quinone 19-26 heat shock protein 90 beta family member 1 Homo sapiens 98-103 25027801-3 2014 Replacement of the quinone moiety of RDA with a phenyl ring (2) was found to be better suited for Grp94 inhibition as it can fully interact with a unique hydrophobic pocket present in Grp94. quinone 19-26 heat shock protein 90 beta family member 1 Homo sapiens 184-189 24874653-1 2014 A series of L-shaped ortho-quinone analogs were designed by analyzing the binding mode with NQO1. quinone 27-34 NAD(P)H quinone dehydrogenase 1 Homo sapiens 92-96 25151970-5 2014 The effect of NQO1 on quinone induced protein handling changes and toxicity was examined using N27 cells stably transfected with NQO1 to generate an isogenic NQO1-overexpressing line. quinone 22-29 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 14-18 25151970-6 2014 NQO1 protected against BQ-induced apoptosis but led to a potentiation of AC- and MD-induced apoptosis. quinone 23-25 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 0-4 25151970-7 2014 Modulation of quinone-induced apoptosis in N27 and NQO1-overexpressing cells correlated only with changes in the ER stress response and not with changes in other protein handling systems. quinone 14-21 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 51-55 25151970-8 2014 These data suggested that NQO1 modulated the ER stress response to potentiate toxicity of AC and MD, but protected against BQ toxicity. quinone 123-125 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 26-30 25117641-3 2014 Despite preclinical efficacy of geldanamycin-anasamycin (GA)-derivatives containing benzoquinone moiety as Hsp90 inhibitors, the hepatotoxicity of these GA-derivatives restricts their therapeutic benefit. quinone 84-96 heat shock protein 90 alpha family class A member 1 Homo sapiens 107-112 24802718-0 2014 Spectroscopic and molecular docking studies on the charge transfer complex of bovine serum albumin with quinone in aqueous medium and its influence on the ligand binding property of the protein. quinone 104-111 albumin Homo sapiens 85-98 24802718-1 2014 The spectral techniques such as UV-Vis, (1)H NMR and fluorescence and electrochemical experiments have been employed to investigate the interaction between 2-methoxy-3,5,6-trichloro-1,4-benzoquinone (MQ; a water soluble quinone) and bovine serum albumin (BSA) in aqueous medium. quinone 191-198 albumin Homo sapiens 240-253 24708242-5 2014 SRY up-regulation occurred via the p-quinone pathway, associated with a 3.5-fold increase in expression of GADD45gamma, a DNA damage inducible factor gene and known SRY regulator. quinone 37-44 sex determining region Y Homo sapiens 0-3 24708242-5 2014 SRY up-regulation occurred via the p-quinone pathway, associated with a 3.5-fold increase in expression of GADD45gamma, a DNA damage inducible factor gene and known SRY regulator. quinone 37-44 sex determining region Y Homo sapiens 165-168 24767847-1 2014 Contradictory reports on the behaviour of hydroquinone as a tyrosinase substrate are reconciled in terms of the ability of the initially formed ortho-quinone to tautomerise to the thermodynamically more stable para-quinone isomer. quinone 210-222 tyrosinase Homo sapiens 60-70 24715002-12 2014 Low concentrations of H2O2 oxidize H4L to a series of semiquinone and quinone compounds with absorption maxima at 314-400 nm, while a high concentration of H2O2 oxidizes H4L to colorless muconic acid derivatives. quinone 58-65 H4 clustered histone 7 Homo sapiens 35-38 25018761-8 2014 NDC1 presumably acts through the reduction of quinone intermediates preceding cyclization by VTE1. quinone 46-53 NDC1 transmembrane nucleoporin Homo sapiens 0-4 24682466-8 2014 19-Phenyl BQAs inhibited purified Hsp90 in a NAD(P)H: quinone oxidoreductase 1 (NQO1)-dependent manner, demonstrating increased efficacy of the hydroquinone ansamycin relative to its parent quinone. quinone 54-61 heat shock protein 90 alpha family class A member 1 Homo sapiens 34-39 24682466-8 2014 19-Phenyl BQAs inhibited purified Hsp90 in a NAD(P)H: quinone oxidoreductase 1 (NQO1)-dependent manner, demonstrating increased efficacy of the hydroquinone ansamycin relative to its parent quinone. quinone 54-61 NAD(P)H quinone dehydrogenase 1 Homo sapiens 80-84