PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
34412587-13	2021	This study reveals that CB2 activation can effectively delay the development of IVDD, providing an effective therapeutic target for IVDD.	ivdd	80-84	cannabinoid receptor 2	Rattus norvegicus	24-27
34412587-13	2021	This study reveals that CB2 activation can effectively delay the development of IVDD, providing an effective therapeutic target for IVDD.	ivdd	132-136	cannabinoid receptor 2	Rattus norvegicus	24-27
32816304-6	2021	In vivo, TNF-alpha accelerated the process of IVDD and suppressed SHOX2 expression; compared to the DP group, WDS was significantly increased in TNF-alpha intradiscal injection group at 2-6 weeks after puncture(p<0.05); In NP cells, TNF-alpha negatively affected the IVDD-associated SHOX2 suppression.	ivdd	46-50	tumor necrosis factor	Canis lupus familiaris	9-18
35013104-4	2022	Inducible deletion of Kindlin-2 in NP cells in adult mice causes spontaneous and striking IVDD-like phenotypes in lumbar IVDs and largely accelerates progression of coccygeal IVDD in the presence of abnormal mechanical stress.	ivdd	90-94	fermitin family member 2	Mus musculus	22-31
35013104-4	2022	Inducible deletion of Kindlin-2 in NP cells in adult mice causes spontaneous and striking IVDD-like phenotypes in lumbar IVDs and largely accelerates progression of coccygeal IVDD in the presence of abnormal mechanical stress.	ivdd	175-179	fermitin family member 2	Mus musculus	22-31
35013104-8	2022	In vivo blocking Nlrp3 inflammasome activation prevents IVDD progression induced by Kindlin-2 loss and abnormal mechanical stress.	ivdd	56-60	NLR family pyrin domain containing 3	Homo sapiens	17-22
35013104-8	2022	In vivo blocking Nlrp3 inflammasome activation prevents IVDD progression induced by Kindlin-2 loss and abnormal mechanical stress.	ivdd	56-60	fermitin family member 2	Mus musculus	84-93
35013104-9	2022	Of translational significance, adeno-associated virus-mediated overexpression of Kindlin-2 inhibits ECM catabolism and cell apoptosis in primary human NP cells in vitro and alleviates coccygeal IVDD progression caused by mechanical stress in rat.	ivdd	194-198	FERM domain containing kindlin 2	Homo sapiens	81-90
35059401-2	2021	Our previous study suggested the protective role of inhibiting heat shock protein 90 (HSP90) in IVDD, while the underlying mechanisms need advanced research.	ivdd	96-100	heat shock protein 90 alpha family class A member 1	Homo sapiens	63-84
35059401-2	2021	Our previous study suggested the protective role of inhibiting heat shock protein 90 (HSP90) in IVDD, while the underlying mechanisms need advanced research.	ivdd	96-100	heat shock protein 90 alpha family class A member 1	Homo sapiens	86-91
35059401-10	2021	In conclusion, HSP90 inhibitor 17-AAG attenuates NP inflammation and catabolism induced by M1 macrophages, suggesting 17-AAG as a promising candidate for IVDD treatment.	ivdd	154-158	N-methylpurine DNA glycosylase	Homo sapiens	121-124
32816304-6	2021	In vivo, TNF-alpha accelerated the process of IVDD and suppressed SHOX2 expression; compared to the DP group, WDS was significantly increased in TNF-alpha intradiscal injection group at 2-6 weeks after puncture(p<0.05); In NP cells, TNF-alpha negatively affected the IVDD-associated SHOX2 suppression.	ivdd	267-271	tumor necrosis factor	Canis lupus familiaris	9-18
32816304-6	2021	In vivo, TNF-alpha accelerated the process of IVDD and suppressed SHOX2 expression; compared to the DP group, WDS was significantly increased in TNF-alpha intradiscal injection group at 2-6 weeks after puncture(p<0.05); In NP cells, TNF-alpha negatively affected the IVDD-associated SHOX2 suppression.	ivdd	267-271	tumor necrosis factor	Canis lupus familiaris	145-154
32816304-6	2021	In vivo, TNF-alpha accelerated the process of IVDD and suppressed SHOX2 expression; compared to the DP group, WDS was significantly increased in TNF-alpha intradiscal injection group at 2-6 weeks after puncture(p<0.05); In NP cells, TNF-alpha negatively affected the IVDD-associated SHOX2 suppression.	ivdd	267-271	tumor necrosis factor	Canis lupus familiaris	145-154
32526705-7	2020	Furthermore, chemerin overexpression aggravates the puncture-induced IVDD progression in rats, while knockdown CMKLR1 reverses IVDD progression.	ivdd	69-73	retinoic acid receptor responder 2	Rattus norvegicus	13-21
32816304-7	2021	While TNF-alpha promotes IVDD through activation of both MAPK and NF-kappaB signaling, it seemed that only NF-kappaB signaling controlled the TNF-alpha-mediated SHOX2 suppression that is associated with IVDD.	ivdd	25-29	tumor necrosis factor	Canis lupus familiaris	6-15
32816304-7	2021	While TNF-alpha promotes IVDD through activation of both MAPK and NF-kappaB signaling, it seemed that only NF-kappaB signaling controlled the TNF-alpha-mediated SHOX2 suppression that is associated with IVDD.	ivdd	203-207	tumor necrosis factor	Canis lupus familiaris	142-151
32816304-7	2021	While TNF-alpha promotes IVDD through activation of both MAPK and NF-kappaB signaling, it seemed that only NF-kappaB signaling controlled the TNF-alpha-mediated SHOX2 suppression that is associated with IVDD.	ivdd	203-207	short stature homeobox 2	Canis lupus familiaris	161-166
32816304-8	2021	The results of this study indicated that TNF-alpha inhibits SHOX2 expression and has promoted effects on IVDD in the rat model, and this effects might be associated with through NF-kappaB signaling pathway and promotes IVDD and related pain in a rat model.	ivdd	105-109	tumor necrosis factor	Rattus norvegicus	41-50
32816304-8	2021	The results of this study indicated that TNF-alpha inhibits SHOX2 expression and has promoted effects on IVDD in the rat model, and this effects might be associated with through NF-kappaB signaling pathway and promotes IVDD and related pain in a rat model.	ivdd	219-223	tumor necrosis factor	Rattus norvegicus	41-50
32816304-8	2021	The results of this study indicated that TNF-alpha inhibits SHOX2 expression and has promoted effects on IVDD in the rat model, and this effects might be associated with through NF-kappaB signaling pathway and promotes IVDD and related pain in a rat model.	ivdd	219-223	short stature homeobox 2	Rattus norvegicus	60-65