PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 32054342-13 2020 In conclusion, FEB exhibited a protective effect in sepsis-induced liver and kidney injuries most probably through its anti-inflammatory, antioxidant, and antiapoptotic properties and attenuating JNK signaling pathway secondary to its XO enzyme inhibitory activity. febuxostat 15-18 mitogen-activated protein kinase 8 Rattus norvegicus 196-199 31748427-8 2020 Serum creatinine (s-Cr) and eGFR were significantly better after 6 months of febuxostat treatment compared with topiroxostat Cystatin-C was significantly lower after 6 months of febuxostat treatment compared with topiroxostat. febuxostat 178-188 cystatin C Homo sapiens 125-135 31677062-3 2020 We postulated that febuxostat, a novel xanthine oxidase inhibitor, could suppress the ER stress through upregulation of SIRT1 (silent mating type information regulation 2 homolog 1)-AMPK (AMP activated protein kinase)-HO-1 (heme oxygenase-1)/thioredoxin expression. febuxostat 19-29 xanthine dehydrogenase Mus musculus 39-55 31677062-3 2020 We postulated that febuxostat, a novel xanthine oxidase inhibitor, could suppress the ER stress through upregulation of SIRT1 (silent mating type information regulation 2 homolog 1)-AMPK (AMP activated protein kinase)-HO-1 (heme oxygenase-1)/thioredoxin expression. febuxostat 19-29 sirtuin 1 Mus musculus 120-125 31677062-3 2020 We postulated that febuxostat, a novel xanthine oxidase inhibitor, could suppress the ER stress through upregulation of SIRT1 (silent mating type information regulation 2 homolog 1)-AMPK (AMP activated protein kinase)-HO-1 (heme oxygenase-1)/thioredoxin expression. febuxostat 19-29 heme oxygenase 1 Mus musculus 224-241 31677062-3 2020 We postulated that febuxostat, a novel xanthine oxidase inhibitor, could suppress the ER stress through upregulation of SIRT1 (silent mating type information regulation 2 homolog 1)-AMPK (AMP activated protein kinase)-HO-1 (heme oxygenase-1)/thioredoxin expression. febuxostat 19-29 thioredoxin 1 Mus musculus 242-253 31677062-8 2020 Inhibitory effect of febuxostat was mediated through upregulation of SIRT1-AMPK followed by induction of HO-1 and thioredoxin. febuxostat 21-31 sirtuin 1 Mus musculus 69-74 31677062-8 2020 Inhibitory effect of febuxostat was mediated through upregulation of SIRT1-AMPK followed by induction of HO-1 and thioredoxin. febuxostat 21-31 heme oxygenase 1 Mus musculus 105-125 31677062-9 2020 In animal model of UUO, febuxostat reduced the UUO-induced ER stress, which was abolished by pretreatment with SIRT1 inhibitor (sirtinol) and AMPK inhibitor (compound C). febuxostat 24-34 sirtuin 1 Mus musculus 111-116 31972252-4 2020 These beneficial effects of nitrate on diabetic mice were abolished by PTIO (NO scavenger) treatment and significantly prevented by febuxostat (xanthine oxidoreductase inhibitor), demonstrating the central importance of NO in bioactivation of nitrate. febuxostat 132-142 xanthine dehydrogenase Mus musculus 144-167 31556223-1 2019 Xanthine oxidoreductase (XOR) inhibitors, such as allopurinol and febuxostat, inhibit the catalysis of serum uric acid (SUA) synthesis. febuxostat 66-76 xanthine dehydrogenase Homo sapiens 0-23 31965018-6 2020 Despite a similar hypouricemic effect of the XO inhibitors on blood UA level, febuxostat, but not allopurinol, significantly decreased hepatic XO activity and UA levels in the NASH model mice. febuxostat 78-88 xanthine dehydrogenase Mus musculus 143-145 31965018-8 2020 Furthermore, in NAFLD patients with hyperuricemia, treatment with febuxostat for 24 weeks decreased the serum UA level, accompanied by reductions in the serum levels of liver enzymes, alanine aminotransferase and aspartate aminotransferase. febuxostat 66-76 glutamic--pyruvic transaminase Homo sapiens 184-208 31754153-3 2019 In this study, we report that febuxostat, an inhibitor of XOR, suppressed NLRP3 inflammasome-mediated IL-1beta secretion and cell death by two mechanisms: in a mitochondrial ROS (mitoROS)-dependent and mitoROS-independent manner. febuxostat 30-40 xanthine dehydrogenase Homo sapiens 58-61 31754153-3 2019 In this study, we report that febuxostat, an inhibitor of XOR, suppressed NLRP3 inflammasome-mediated IL-1beta secretion and cell death by two mechanisms: in a mitochondrial ROS (mitoROS)-dependent and mitoROS-independent manner. febuxostat 30-40 NLR family pyrin domain containing 3 Homo sapiens 74-79 31754153-3 2019 In this study, we report that febuxostat, an inhibitor of XOR, suppressed NLRP3 inflammasome-mediated IL-1beta secretion and cell death by two mechanisms: in a mitochondrial ROS (mitoROS)-dependent and mitoROS-independent manner. febuxostat 30-40 interleukin 1 beta Homo sapiens 102-110 31882426-7 2019 However, febuxostat treatment also decreased URAT1 expression, whereas benzbromarone treatment increased its expression. febuxostat 9-19 solute carrier family 22 (organic anion/cation transporter), member 12 Mus musculus 45-50 31560952-5 2019 Plasma and kidney xanthine oxidoreductase levels were decreased by febuxostat. febuxostat 67-77 xanthine dehydrogenase Mus musculus 18-41 31560952-8 2019 Furthermore, febuxostat enhanced AMPK phosphorylation and inhibited Nox1, Nox2, and HIF-1alpha expression in iohexol-exposed HK-2 cells. febuxostat 13-23 NADPH oxidase 1 Mus musculus 68-72 31560952-8 2019 Furthermore, febuxostat enhanced AMPK phosphorylation and inhibited Nox1, Nox2, and HIF-1alpha expression in iohexol-exposed HK-2 cells. febuxostat 13-23 cytochrome b-245, beta polypeptide Mus musculus 74-78 31560952-8 2019 Furthermore, febuxostat enhanced AMPK phosphorylation and inhibited Nox1, Nox2, and HIF-1alpha expression in iohexol-exposed HK-2 cells. febuxostat 13-23 hypoxia inducible factor 1, alpha subunit Mus musculus 84-94 31546603-2 2019 Since DKD is the most common cause of end-stage renal disease, we investigated whether febuxostat, a xanthine oxidase (XO) inhibitor, exerts a protective effect against the development of DKD. febuxostat 87-97 xanthine dehydrogenase Mus musculus 101-117 31546603-2 2019 Since DKD is the most common cause of end-stage renal disease, we investigated whether febuxostat, a xanthine oxidase (XO) inhibitor, exerts a protective effect against the development of DKD. febuxostat 87-97 xanthine dehydrogenase Mus musculus 119-121 31546603-8 2019 Interestingly, the IL-1beta, IL-6, MCP-1, and ICAM-1 mRNA levels, which were increased in KK-Ay mouse kidneys as compared with normal controls, were suppressed by febuxostat administration. febuxostat 163-173 interleukin 1 beta Mus musculus 19-27 31546603-8 2019 Interestingly, the IL-1beta, IL-6, MCP-1, and ICAM-1 mRNA levels, which were increased in KK-Ay mouse kidneys as compared with normal controls, were suppressed by febuxostat administration. febuxostat 163-173 interleukin 6 Mus musculus 29-33 31546603-8 2019 Interestingly, the IL-1beta, IL-6, MCP-1, and ICAM-1 mRNA levels, which were increased in KK-Ay mouse kidneys as compared with normal controls, were suppressed by febuxostat administration. febuxostat 163-173 mast cell protease 1 Mus musculus 35-40 31546603-8 2019 Interestingly, the IL-1beta, IL-6, MCP-1, and ICAM-1 mRNA levels, which were increased in KK-Ay mouse kidneys as compared with normal controls, were suppressed by febuxostat administration. febuxostat 163-173 intercellular adhesion molecule 1 Mus musculus 46-52