PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
7397182-1	1980	It has been shown that beta-2"-deoxy-6-thioguanosine is incorporated into mammalian DNA via its triphosphate form.	triphosphoric acid	96-108	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	23-29
6759088-0	1982	[Modification of the catalytic center of Escherichia coli ATP(CTP): tRNA-nucleotidyltransferase by adenosine and cytidine triphosphate derivatives with a reactive group in the triphosphate fragment].	triphosphoric acid	122-134	ATPase	Escherichia coli	58-66
6453626-1	1981	Some properties of three interconvertible forms of rabbit muscle phosphofructokinase specifically eluted from DEAE-cellulose with 19 mM citrate in 0.1 M tris-phosphate buffer, pH 8,0 (I), with 0,3 M buffer (II) and 1.5 M NaCl (III) are compared.	triphosphoric acid	153-167	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	65-84
6453610-2	1980	When irradiated 8-azido-ATP becomes covalently bound (as the nitreno compound) to beef-heart mitochondrial ATPase (F1) as the triphosphate, either in the absence or presence of Mg2+, label covalently bound is not hydrolysed.	triphosphoric acid	126-138	ATP synthase F1 subunit epsilon	Homo sapiens	93-113
6967747-2	1980	Inhibition of adenosine deaminase activity resulted in (1) an abrupt rise in plasma deoxyadenosine, but not adenosine, concentrations; (2) accumulation of deoxyadenosine triphosphate by lymphoblasts; (3) inhibition of the enzyme S-adenoylhomocysteine hydrolase; and (4) rapid lysis of the leukemic cells.	triphosphoric acid	170-182	adenosine deaminase	Homo sapiens	14-33
33706135-0	2021	Effect of sodium tripolyphosphate on the interaction and aggregation behavior of ovalbumin-lysozyme complex.	triphosphoric acid	10-33	lysozyme	Homo sapiens	91-99
20164-0	1977	[Comparative kinetic studies of Mg2+-activated hydrolysis of tripolyphosphate and pyrophosphate by inorganic pyrophosphatase].	triphosphoric acid	61-77	inorganic pyrophosphatase 1	Homo sapiens	99-124
1056353-1	1975	Treatment of human enamel powder with cyclic trimetaphosphate or linear tripolyphosphate changes subsequent adsorption of amylase, lysozyme, and salivary protein from aqueous solutions.	triphosphoric acid	72-88	lysozyme	Homo sapiens	131-139
16811008-2	1963	Thrombin-induced aggregation is also inhibited by adenosine and the monophosphate, but the triphosphate at a similar concentration is not inhibitory.	triphosphoric acid	91-103	coagulation factor II, thrombin	Homo sapiens	0-8
600797-2	1977	The two-step procedure involves the chemical synthesis of the mononucleotide followed by its enzymic conversion to the triphosphate with myokinase (EC 2.7.4.3) and pyruvate kinase (EC 2.7.1.40) in the presence of trace amounts of dATP or ATP to prime the reaction.	triphosphoric acid	119-131	adenylate kinase 1	Homo sapiens	137-146
33752114-6	2021	Furthermore, with different crosslinkers and concentrations in the crosslinking process, the release properties and safety of the hydrogels were varied, but the STPP-crosslinked CS hydrogel presented good cell adhesivity for bioactive components to the colon.	triphosphoric acid	161-165	citrate synthase	Homo sapiens	178-180
33706135-1	2021	The mechanism by which sodium tripolyphosphate affected the aggregation behavior of ovalbumin-lysozyme complexes was investigated in this work.	triphosphoric acid	23-46	lysozyme	Homo sapiens	94-102
33730849-5	2021	Here, we show that additional attractive interactions between arginine and tripolyphosphate determine the re-entrant condensation and decondensation boundaries of the cationic, intrinsically disordered saliva protein, histatin 5.	triphosphoric acid	75-91	histatin 3	Homo sapiens	218-228
33988981-1	2021	SAMHD1 is a fundamental regulator of cellular dNTPs that catalyzes their hydrolysis into 2"-deoxynucleoside and triphosphate, restricting the replication of viruses, including HIV-1, in CD4+ myeloid lineage and resting T-cells.	triphosphoric acid	112-124	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
33988981-1	2021	SAMHD1 is a fundamental regulator of cellular dNTPs that catalyzes their hydrolysis into 2"-deoxynucleoside and triphosphate, restricting the replication of viruses, including HIV-1, in CD4+ myeloid lineage and resting T-cells.	triphosphoric acid	112-124	CD4 molecule	Homo sapiens	186-189
33894278-3	2021	However, the cell-free SARS-CoV-2 RdRp biochemical assay requires the conversion of nucleotide prodrugs into the active triphosphate forms, which regularly occurs in cells yet is a complicated multiple-step chemical process in vitro, and thus hinders the utility of this cell-free assay in the rapid discovery of RdRp inhibitors.	triphosphoric acid	120-132	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	34-38
33894278-3	2021	However, the cell-free SARS-CoV-2 RdRp biochemical assay requires the conversion of nucleotide prodrugs into the active triphosphate forms, which regularly occurs in cells yet is a complicated multiple-step chemical process in vitro, and thus hinders the utility of this cell-free assay in the rapid discovery of RdRp inhibitors.	triphosphoric acid	120-132	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	313-317
33593557-1	2021	To control the release of nerve growth factor (NGF) in the injured peripheral nerve, NGF-loaded chitosan/PLGA composite microspheres ionically cross-linked by tripolyphosphate (TPP/Chitosan/PLGA-NGF) were prepared.	triphosphoric acid	159-175	nerve growth factor	Rattus norvegicus	85-88
33593557-1	2021	To control the release of nerve growth factor (NGF) in the injured peripheral nerve, NGF-loaded chitosan/PLGA composite microspheres ionically cross-linked by tripolyphosphate (TPP/Chitosan/PLGA-NGF) were prepared.	triphosphoric acid	159-175	nerve growth factor	Rattus norvegicus	85-88
33903070-2	2021	The nucleoside diphosphate kinase (NDPK) activity of NME1 is well recognized in balancing the intracellular pools of nucleotide diphosphates and triphosphates to regulate cytoskeletal rearrangement and cell motility, endocytosis, intracellular trafficking, and metastasis.	triphosphoric acid	145-158	cytidine/uridine monophosphate kinase 2	Homo sapiens	4-33
33903070-2	2021	The nucleoside diphosphate kinase (NDPK) activity of NME1 is well recognized in balancing the intracellular pools of nucleotide diphosphates and triphosphates to regulate cytoskeletal rearrangement and cell motility, endocytosis, intracellular trafficking, and metastasis.	triphosphoric acid	145-158	cytidine/uridine monophosphate kinase 2	Homo sapiens	35-39
33903070-2	2021	The nucleoside diphosphate kinase (NDPK) activity of NME1 is well recognized in balancing the intracellular pools of nucleotide diphosphates and triphosphates to regulate cytoskeletal rearrangement and cell motility, endocytosis, intracellular trafficking, and metastasis.	triphosphoric acid	145-158	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	53-57
33421534-7	2021	The trypanosome IP3R is stimulated by luminal phosphate and pyrophosphate, which are hydrolysis products of polyphosphate (polyP), and inhibited by tripolyphosphate (polyP3), which is the most abundant polyP in acidocalcisomes.	triphosphoric acid	148-164	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	16-20
33476709-8	2021	Incubation of MBX-2168 alone or with dCF in Vero cells resulted in 12.8+-0.1 and 6.7+-0.7 pmol triphosphate/106 cells at 24 hours, respectively.	triphosphoric acid	95-107	diencephalon/mesencephalon homeobox 1	Homo sapiens	14-17
33538616-1	2021	In the current study erythropoietin (EPO) loaded trimethyl chitosan/tripolyphosphate nanoparticles-embedded in a thermosensitive hydrogel was prepared.	triphosphoric acid	68-84	erythropoietin	Rattus norvegicus	21-35
33538616-1	2021	In the current study erythropoietin (EPO) loaded trimethyl chitosan/tripolyphosphate nanoparticles-embedded in a thermosensitive hydrogel was prepared.	triphosphoric acid	68-84	erythropoietin	Rattus norvegicus	37-40
33656855-4	2021	Here we show that MAT2A has a sequential mechanism with a rate-limiting step of formation of AdoMet, followed by rapid hydrolysis of the beta-gamma bond of triphosphate, and rapid release of phosphate and pyrophosphate.	triphosphoric acid	156-168	methionine adenosyltransferase 2A	Homo sapiens	18-23
33656855-5	2021	MAT2A catalyzes the slow hydrolysis of both ATP and triphosphate in the absence of other reactants.	triphosphoric acid	52-64	methionine adenosyltransferase 2A	Homo sapiens	0-5
33476709-11	2021	We conclude that dCF antagonizes the anti-viral effect of MBX-2168 by inhibiting the production of triphosphate, the active compound.	triphosphoric acid	99-111	diencephalon/mesencephalon homeobox 1	Homo sapiens	58-61
33281478-2	2021	The recent elucidation of the experimental structure of SARS-CoV-2 RdRp enzyme complexed with triphosphate form of Remdesivir (RTP) has opened an avenue for structure-based identification of potent inhibitors.	triphosphoric acid	94-106	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	67-71
33424274-0	2020	Developed simvastatin chitosan nanoparticles co-crosslinked with tripolyphosphate and chondroitin sulfate for ASGPR-mediated targeted HCC delivery with enhanced oral bioavailability.	triphosphoric acid	65-81	asialoglycoprotein receptor 1	Homo sapiens	110-115
33052071-9	2021	Chimeric CD39-CD73-ECD proteins were superior in converting triphosphate and diphosphate nucleotides into nucleosides when compared with ALP-ECD and HAP-ECD.	triphosphoric acid	60-72	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	9-13
33052071-9	2021	Chimeric CD39-CD73-ECD proteins were superior in converting triphosphate and diphosphate nucleotides into nucleosides when compared with ALP-ECD and HAP-ECD.	triphosphoric acid	60-72	5'-nucleotidase ecto	Homo sapiens	14-18
33281478-2	2021	The recent elucidation of the experimental structure of SARS-CoV-2 RdRp enzyme complexed with triphosphate form of Remdesivir (RTP) has opened an avenue for structure-based identification of potent inhibitors.	triphosphoric acid	94-106	MORN repeat containing 4	Homo sapiens	127-130
33371382-4	2020	In a structure-based design approach, four representative derivatives were docked into an in-house model of an active triphosphate-containing BRAF protein, and the interactions established were analysed.	triphosphoric acid	118-130	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	142-146
33184222-3	2020	Reducing DUSP11 levels alters host triphosphate RNA packaged in extracellular vesicles and induces enhanced RIG-I activation in cells exposed to extracellular vesicles.	triphosphoric acid	35-47	dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)	Mus musculus	9-15
32692185-2	2020	On the basis of our analysis of hepatitis C virus and coronavirus replication, and the molecular structures and activities of viral inhibitors, we previously demonstrated that three nucleotide analogues (the triphosphates of Sofosbuvir, Alovudine, and AZT) inhibit the SARS-CoV RNA-dependent RNA polymerase (RdRp).	triphosphoric acid	208-221	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	308-312
32958712-7	2020	At 100 mg/kg BID, the terminal triphosphate concentration in PBMCs reached above TP50, demonstrating TP50 as the target exposure for efficacy.	triphosphoric acid	31-43	BH3 interacting domain death agonist	Mus musculus	13-16
32692185-4	2020	Here, we used polymerase extension experiments to demonstrate that the active triphosphate form of Sofosbuvir (an FDA-approved hepatitis C drug) is incorporated by SARS-CoV-2 RdRp and blocks further incorporation.	triphosphoric acid	78-90	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	175-179
32692185-5	2020	Using the molecular insight gained from the previous studies, we selected the active triphosphate forms of six other antiviral agents, Alovudine, Tenofovir alafenamide, AZT, Abacavir, Lamivudine, and Emtricitabine, for evaluation as inhibitors of the SARS-CoV-2 RdRp and demonstrated the ability of these viral polymerase inhibitors to be incorporated by SARS-CoV-2 RdRp, where they terminate further polymerase extension with varying efficiency.	triphosphoric acid	85-97	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	262-266
32692185-5	2020	Using the molecular insight gained from the previous studies, we selected the active triphosphate forms of six other antiviral agents, Alovudine, Tenofovir alafenamide, AZT, Abacavir, Lamivudine, and Emtricitabine, for evaluation as inhibitors of the SARS-CoV-2 RdRp and demonstrated the ability of these viral polymerase inhibitors to be incorporated by SARS-CoV-2 RdRp, where they terminate further polymerase extension with varying efficiency.	triphosphoric acid	85-97	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	366-370
32034313-9	2020	Furthermore, the presence of 5" mono- and 5" triphosphate structures on vRNA was not required for the formation of XRN1-DCP1/2-vRC-containing foci.	triphosphoric acid	45-57	vault RNA 1-1	Homo sapiens	72-76
32562705-2	2020	We previously demonstrated that five nucleotide analogues inhibit the SARS-CoV-2 RNA-dependent RNA polymerase (RdRp), including the active triphosphate forms of Sofosbuvir, Alovudine, Zidovudine, Tenofovir alafenamide and Emtricitabine.	triphosphoric acid	139-151	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	111-115
32501800-4	2020	Here, we determined structures of Tribolium castaneum telomerase reverse transcriptase (TERT) throughout its catalytic cycle and mapped the active site residues responsible for nucleoside selection, metal coordination, triphosphate binding, and RNA template stabilization.	triphosphoric acid	219-231	telomerase reverse transcriptase	Tribolium castaneum	54-86
32576829-1	2020	SAMHD1 regulates cellular 2"-deoxynucleoside-5"-triphosphate (dNTP) homeostasis by catalysing the hydrolysis of dNTPs into 2"-deoxynucleosides and triphosphate.	triphosphoric acid	48-60	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
32501800-4	2020	Here, we determined structures of Tribolium castaneum telomerase reverse transcriptase (TERT) throughout its catalytic cycle and mapped the active site residues responsible for nucleoside selection, metal coordination, triphosphate binding, and RNA template stabilization.	triphosphoric acid	219-231	telomerase reverse transcriptase	Tribolium castaneum	88-92
32154932-7	2020	We found that the efficiency to serve as cofactor for UBA1/UBA6 very much depends on the length of the phosphate chain of the ATP analogue: triphosphates are used poorly while pentaphosphates are most efficiently processed.	triphosphoric acid	140-153	ubiquitin like modifier activating enzyme 1	Homo sapiens	54-58
32154932-7	2020	We found that the efficiency to serve as cofactor for UBA1/UBA6 very much depends on the length of the phosphate chain of the ATP analogue: triphosphates are used poorly while pentaphosphates are most efficiently processed.	triphosphoric acid	140-153	ubiquitin like modifier activating enzyme 6	Homo sapiens	59-63
31940473-11	2020	The active triphosphate form of FCV (FCV-TP) reaches higher peak levels than GCV-TP in HCMV-infected cells, and exhibits about 10-fold higher affinity to HCMV DNA polymerase UL54.	triphosphoric acid	11-23	DNA polymerase catalytic subunit	Human betaherpesvirus 5	174-178
32284326-5	2020	Enzyme kinetics indicated that this RdRp efficiently incorporates the active triphosphate form of RDV (RDV-TP) into RNA.	triphosphoric acid	77-89	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	36-40
32511320-3	2020	Here, using polymerase extension experiments, we have demonstrated that the active triphosphate form of Sofosbuvir (a key component of the FDA approved hepatitis C drug EPCLUSA), is incorporated by SARS-CoV-2 RdRp, and blocks further incorporation.	triphosphoric acid	83-95	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	209-213
32244340-3	2020	When active, dNTP triphosphohydrolase activity of SAMHD1 degrades dNTPs into their 2"-deoxynucleoside (dN) and triphosphate subparts, steadily depleting intercellular dNTP pools.	triphosphoric acid	111-123	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	50-56
32511320-4	2020	Using the same molecular insight, we selected the active triphosphate forms of three other anti-viral agents, Alovudine, AZT (an FDA approved HIV/AIDS drug) and Tenofovir alafenamide (TAF, an FDA approved drug for HIV and hepatitis B) for evaluation as inhibitors of SARS-CoV-2 RdRp.	triphosphoric acid	57-69	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	278-282
32511320-5	2020	We demonstrated the ability of these three viral polymerase inhibitors, 3"-fluoro-3"-deoxythymidine triphosphate, 3"-azido-3"-deoxythymidine triphosphate and Tenofovir diphosphate (the active triphosphate forms of Alovudine, AZT and TAF, respectively) to be incorporated by SARS-CoV-2 RdRp, where they also terminate further polymerase extension.	triphosphoric acid	100-112	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	285-289
31906446-4	2020	These increases were dependent upon CdtB"s ability to function as a phosphatidylinositol (PI) 3,4,5-triphosphate (PIP3) phosphatase.	triphosphoric acid	96-112	corneal dystrophy of Bowman's layer type II (Thiel-Behnke)	Homo sapiens	36-40
31950591-3	2020	The dNTPase SAMHD1, which regulates dNTP homoeostasis antagonistically to ribonucleotide reductase (RNR), limits ara-C efficacy by hydrolysing the active triphosphate metabolite ara-CTP.	triphosphoric acid	154-166	SAM domain and HD domain, 1	Mus musculus	12-18
31968222-5	2020	Incubation of HCMV-infected cells with five times the EC50 of MBX-2168 (4.0 muM), synguanol (10.5 muM), or GCV (25 muM) resulted in a time-dependent increase in triphosphate accumulation reaching a maximum of 48.1 +- 5.5, 45.5 +- 2.5, and 42.6 +- 3.7 pmol/106 cells at 120 h, respectively.	triphosphoric acid	161-173	diencephalon/mesencephalon homeobox 1	Homo sapiens	62-65
31968222-7	2020	HSV-1-infected cells incubated with five times the EC50 of MBX-2168 (33.5 muM) or ACV (5.0 muM) demonstrated a time-dependent increase in triphosphate levels reaching a maximum of 12.3 +- 1.5 and 11.6 +- 0.7 pmol/106 cells at 24 h, respectively.	triphosphoric acid	138-150	diencephalon/mesencephalon homeobox 1	Homo sapiens	59-62
31968222-7	2020	HSV-1-infected cells incubated with five times the EC50 of MBX-2168 (33.5 muM) or ACV (5.0 muM) demonstrated a time-dependent increase in triphosphate levels reaching a maximum of 12.3 +- 1.5 and 11.6 +- 0.7 pmol/106 cells at 24 h, respectively.	triphosphoric acid	138-150	latexin	Homo sapiens	74-77
31968222-7	2020	HSV-1-infected cells incubated with five times the EC50 of MBX-2168 (33.5 muM) or ACV (5.0 muM) demonstrated a time-dependent increase in triphosphate levels reaching a maximum of 12.3 +- 1.5 and 11.6 +- 0.7 pmol/106 cells at 24 h, respectively.	triphosphoric acid	138-150	latexin	Homo sapiens	91-94
31939244-2	2020	Methods: NGF loaded chitosan-PLGA double-walled microspheres were prepared by emulsion-ionic method with sodium tripolyphosphate (TPP) as an ionic cross-linker.	triphosphoric acid	105-128	nerve growth factor	Rattus norvegicus	9-12
31939244-2	2020	Methods: NGF loaded chitosan-PLGA double-walled microspheres were prepared by emulsion-ionic method with sodium tripolyphosphate (TPP) as an ionic cross-linker.	triphosphoric acid	130-133	nerve growth factor	Rattus norvegicus	9-12
31987151-3	2020	Subsequently, the TdT can catalyze the elongation of the SD with free 3"-OH termini and formation of many G-quadruplex sequence replicates with the presence of 2"-deoxyaguanosine-5"-triphosphate (dGTP) and adenosine 5"-triphosphate (dATP) at a molar ratio of 6:4.	triphosphoric acid	160-194	DNA nucleotidylexotransferase	Homo sapiens	18-21
31987151-3	2020	Subsequently, the TdT can catalyze the elongation of the SD with free 3"-OH termini and formation of many G-quadruplex sequence replicates with the presence of 2"-deoxyaguanosine-5"-triphosphate (dGTP) and adenosine 5"-triphosphate (dATP) at a molar ratio of 6:4.	triphosphoric acid	196-200	DNA nucleotidylexotransferase	Homo sapiens	18-21
31600877-2	2019	By degrading cellular dNTPs to constituent deoxynucleoside and free triphosphate, SAMHD1 limits viral DNA synthesis and prevents replication of HIV-1 and some DNA viruses such as HBV, vaccinia, and HSV-1.	triphosphoric acid	68-80	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	82-88
30301919-4	2018	We show that even the triphosphate (PPPi) moiety alone was capable of activating RyR2 but produced two distinct effects (activation or irreversible inactivation) that we suggest correspond to two preferred binding locations within the ATP site.	triphosphoric acid	22-34	ryanodine receptor 2	Homo sapiens	81-85
31017331-2	2019	Active SAMHD1 tetramers are assembled by GTP-Mg+2-dNTP cross bridges and cleave the triphosphate groups of dNTPs at a K m of ~10 muM, which is consistent with dNTP concentrations in cycling cells, but far higher than the equivalent concentration in quiescent cells.	triphosphoric acid	84-96	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	7-13
31017331-2	2019	Active SAMHD1 tetramers are assembled by GTP-Mg+2-dNTP cross bridges and cleave the triphosphate groups of dNTPs at a K m of ~10 muM, which is consistent with dNTP concentrations in cycling cells, but far higher than the equivalent concentration in quiescent cells.	triphosphoric acid	84-96	latexin	Homo sapiens	129-132
31296733-1	2019	Vertebrate protein SAMHD1 (sterile-alpha-motif and HD domain containing protein 1) regulates the cellular dNTP (2"-deoxynucleoside-5"-triphosphate) pool by catalysing the hydrolysis of dNTP into 2"-deoxynucleoside and triphosphate products.	triphosphoric acid	134-146	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	19-25
30465996-1	2019	We have successfully encapsulated two proteins, bovine serum albumin (BSA) and p53, in chitosan-tripolyphosphate (TPP) nanoparticles at various pH values from 5.5 to 6.5 and delivered the particles to human melanoma cells.	triphosphoric acid	96-112	tumor protein p53	Homo sapiens	79-82
31332074-8	2019	We therefore conclude that ADAL-1 is the enzyme responsible for removing the moiety from the guanine ring of MBX-2168-MP prior to conversion to a triphosphate, the active compound that inhibits the viral DNA polymerase.	triphosphoric acid	146-158	diencephalon/mesencephalon homeobox 1	Homo sapiens	109-112
31043531-1	2019	Virus-derived double-stranded RNA (dsRNA) molecules containing a triphosphate group at the 5" end are natural ligands of retinoic acid-inducible gene I (RIG-I).	triphosphoric acid	65-77	DExD/H-box helicase 58	Homo sapiens	153-158
30632402-4	2019	TMC and chitosan (CS) nanoparticles containing inclusion complex were prepared by ionic gelation using sodium tripolyphosphate (TPP).	triphosphoric acid	103-126	citrate synthase	Homo sapiens	18-20
30632402-4	2019	TMC and chitosan (CS) nanoparticles containing inclusion complex were prepared by ionic gelation using sodium tripolyphosphate (TPP).	triphosphoric acid	128-131	citrate synthase	Homo sapiens	18-20
30537806-3	2019	Herein, we used insulin as a model protein drug; insulin-loaded N-(2-hydroxy)-propyl-3-trimethylammonium chloride modified chitosan (HTCC)/sodium tripolyphosphate (TPP) nanocomplex (NC) as a nanocore was further encapsulated into enteric Eudragit L100-55 material, through a two-step flash nanocomplexation (FNC) process in a reliable and scalable manner, forming our NC-in-Eudragit composite particles (NE).	triphosphoric acid	139-162	insulin	Homo sapiens	49-56
30537806-3	2019	Herein, we used insulin as a model protein drug; insulin-loaded N-(2-hydroxy)-propyl-3-trimethylammonium chloride modified chitosan (HTCC)/sodium tripolyphosphate (TPP) nanocomplex (NC) as a nanocore was further encapsulated into enteric Eudragit L100-55 material, through a two-step flash nanocomplexation (FNC) process in a reliable and scalable manner, forming our NC-in-Eudragit composite particles (NE).	triphosphoric acid	164-167	insulin	Homo sapiens	49-56
30453642-2	2018	An emulsification processing method was developed for producing TGF-beta1-loaded CH-PLA/HA microspheres using sodium tripolyphosphate (TPP) as ionic crosslinker and the size of the microspheres was devised to the micron level in order to achieve high encapsulating efficiency.	triphosphoric acid	110-133	transforming growth factor beta 1	Homo sapiens	64-73
30453642-2	2018	An emulsification processing method was developed for producing TGF-beta1-loaded CH-PLA/HA microspheres using sodium tripolyphosphate (TPP) as ionic crosslinker and the size of the microspheres was devised to the micron level in order to achieve high encapsulating efficiency.	triphosphoric acid	135-138	transforming growth factor beta 1	Homo sapiens	64-73
30301919-4	2018	We show that even the triphosphate (PPPi) moiety alone was capable of activating RyR2 but produced two distinct effects (activation or irreversible inactivation) that we suggest correspond to two preferred binding locations within the ATP site.	triphosphoric acid	22-34	ATPase phospholipid transporting 8A2	Homo sapiens	235-238
29866875-9	2018	Levels of liver triphosphate following oral administration of GS2 in animals were higher than those of GS-6620, even when administered under optimal conditions for GS-6620 absorption.	triphosphoric acid	16-28	patatin like phospholipase domain containing 4	Homo sapiens	62-65
31259701-4	2018	Erythropoietin incorporated in chitosan or chitosan-trimethylchitosan (CS-TMC) nanoparticles prepared by polyelectrolyte complexation and ionotropic gelation with tripolyphosphate also showed different surface hydrophobicities.	triphosphoric acid	163-179	erythropoietin	Homo sapiens	0-14
30127789-9	2018	This deoxynucleoside triphosphate triphosphohydrolase counteracts HIV-1 reverse transcription (RT) in resting cells via its dual function as dNTPase, catalyzing deoxynucleotide triphosphates into deoxynucleosides and inorganic triphosphate, and as exonuclease able to degrade single-stranded RNAs.	triphosphoric acid	177-190	NTPase	Drosophila melanogaster	141-148
30127789-9	2018	This deoxynucleoside triphosphate triphosphohydrolase counteracts HIV-1 reverse transcription (RT) in resting cells via its dual function as dNTPase, catalyzing deoxynucleotide triphosphates into deoxynucleosides and inorganic triphosphate, and as exonuclease able to degrade single-stranded RNAs.	triphosphoric acid	217-239	NTPase	Drosophila melanogaster	141-148
29987005-5	2018	We show that N6FFA restores N17 phosphorylation levels by being salvaged to a triphosphate form by adenine phosphoribosyltransferase (APRT) and used as a phosphate donor by casein kinase 2 (CK2).	triphosphoric acid	78-90	adenine phosphoribosyl transferase	Mus musculus	99-132
29987005-5	2018	We show that N6FFA restores N17 phosphorylation levels by being salvaged to a triphosphate form by adenine phosphoribosyltransferase (APRT) and used as a phosphate donor by casein kinase 2 (CK2).	triphosphoric acid	78-90	adenine phosphoribosyl transferase	Mus musculus	134-138
29987005-8	2018	We present a model in which this natural product compound is salvaged to provide a triphosphate substrate to signal huntingtin phosphorylation via CK2 during low-ATP stress under conditions of DNA damage, with protective effects in HD model systems.	triphosphoric acid	83-95	huntingtin	Mus musculus	116-126
29987005-8	2018	We present a model in which this natural product compound is salvaged to provide a triphosphate substrate to signal huntingtin phosphorylation via CK2 during low-ATP stress under conditions of DNA damage, with protective effects in HD model systems.	triphosphoric acid	83-95	casein kinase 2, alpha prime polypeptide	Mus musculus	147-150
29691001-1	2018	Ionically crosslinked chitosan/tripolyphosphate (Chit/TPP) particles have been widely tested in biomedical applications, particularly as potential carriers for controlled drug delivery.	triphosphoric acid	31-47	chitinase 1	Homo sapiens	49-53
29732888-3	2018	Nano-C3G was developed from chitosan and sodium tripolyphosphate (TPP) by ionic gelation.	triphosphoric acid	41-64	Rap guanine nucleotide exchange factor (GEF) 1	Mus musculus	5-8
29732888-3	2018	Nano-C3G was developed from chitosan and sodium tripolyphosphate (TPP) by ionic gelation.	triphosphoric acid	66-69	Rap guanine nucleotide exchange factor (GEF) 1	Mus musculus	5-8
29560565-10	2018	What"s more, CKGM/QKGM/OVA NPs elicited both higher IL-2 and IFN-gamma production, while TPP/QKGM/OVA NPs elicited both higher IL-4 and IL-10 production.	triphosphoric acid	89-92	interleukin 4	Mus musculus	127-131
29583030-1	2018	Sterile alpha motif and histidine-aspartic acid domain-containing protein 1 (SAMHD1) is a deoxynucleotide triphosphate (dNTP) hydrolase that plays an important role in the homeostatic balance of cellular dNTPs.	triphosphoric acid	106-118	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	77-83
28861857-1	2018	Human guanylate kinase (hGMPK) is a critical enzyme that, in addition to phosphorylating its physiological substrate (d)GMP, catalyzes the second phosphorylation step in the conversion of anti-viral and anti-cancer nucleoside analogs to their corresponding active nucleoside analog triphosphates.	triphosphoric acid	282-295	guanylate kinase 1	Homo sapiens	6-22
29560565-10	2018	What"s more, CKGM/QKGM/OVA NPs elicited both higher IL-2 and IFN-gamma production, while TPP/QKGM/OVA NPs elicited both higher IL-4 and IL-10 production.	triphosphoric acid	89-92	interleukin 10	Mus musculus	136-141
29204722-3	2017	The NGF-CNPs were prepared by ionotropic gelation method with tripolyphosphate (TPP) as an ionic cross-linking agent.	triphosphoric acid	62-78	nerve growth factor	Canis lupus familiaris	4-7
29445279-0	2018	EGFR-targeted photodynamic therapy by curcumin-encapsulated chitosan/TPP nanoparticles.	triphosphoric acid	69-72	epidermal growth factor receptor	Homo sapiens	0-4
29445279-8	2018	Conclusion: These curcumin-encapsulated chitosan/TPP nanoparticles are a promising targeted-PDT against EGFR-overexpressing cancers.	triphosphoric acid	49-52	epidermal growth factor receptor	Homo sapiens	104-108
29995566-1	2018	Nucleoside diphosphate kinase (NDPK) catalyzes the interconversion of nucleoside diphosphates and triphosphates using ATP as phosphate donor.	triphosphoric acid	98-111	cytidine/uridine monophosphate kinase 2	Homo sapiens	0-29
29995566-1	2018	Nucleoside diphosphate kinase (NDPK) catalyzes the interconversion of nucleoside diphosphates and triphosphates using ATP as phosphate donor.	triphosphoric acid	98-111	cytidine/uridine monophosphate kinase 2	Homo sapiens	31-35
29576747-4	2018	Although dynamic Ca2+ regulation is complex, phospholipase C/inositol tris-phosphate (PLC/IP3) and CD38-cyclic ADP-ribose (CD38/cADPR) are two major pathways mediating agonist-induced Ca2+ regulation in airway smooth muscle.	triphosphoric acid	70-84	heparan sulfate proteoglycan 2	Homo sapiens	86-89
29204722-3	2017	The NGF-CNPs were prepared by ionotropic gelation method with tripolyphosphate (TPP) as an ionic cross-linking agent.	triphosphoric acid	80-83	nerve growth factor	Canis lupus familiaris	4-7
28542039-2	2017	ECyd is phosphorylated to 3"-ethyntlcytidine 5"-monophosphate by uridine/cytidine kinase 2 (UCK2) and subsequently further to diphosphate and triphosphate (3"-ethyntlcytidine 5"-diphosphate, 3"-ethyntlcytidine 5"-triphosphate).	triphosphoric acid	142-154	uridine-cytidine kinase 2	Homo sapiens	92-96
28956227-4	2017	In a manner similar to CD39, NTPDase3/CD39L3 uses ATP as its preferential substrate and also possesses significant activities toward other triphosphate and diphosphate nucleosides.	triphosphoric acid	139-151	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	23-27
28956227-4	2017	In a manner similar to CD39, NTPDase3/CD39L3 uses ATP as its preferential substrate and also possesses significant activities toward other triphosphate and diphosphate nucleosides.	triphosphoric acid	139-151	ectonucleoside triphosphate diphosphohydrolase 3	Homo sapiens	29-37
28956227-4	2017	In a manner similar to CD39, NTPDase3/CD39L3 uses ATP as its preferential substrate and also possesses significant activities toward other triphosphate and diphosphate nucleosides.	triphosphoric acid	139-151	ectonucleoside triphosphate diphosphohydrolase 3	Homo sapiens	38-44
28829068-3	2017	As target DNA hybridized with the surface-confined capture probes, the exposed 3"-OH terminal of the target sequence could be triggered to elongate in the presence of terminal deoxynucleoside transferase (TdT) and deoxy-ribonucleoside triphosphate (dNTP), thereby producing an evident mass effect.	triphosphoric acid	235-247	DNA nucleotidylexotransferase	Homo sapiens	205-208
28363565-4	2017	Zn-CNP were synthesized using tri-polyphosphate as a cross-linker.	triphosphoric acid	30-47	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	3-6
28502830-5	2017	However, SAMHD1 also can act as a resistance factor to nucleoside-based chemotherapies by hydrolyzing their active triphosphate metabolites, thereby reducing response of various malignancies to these anticancer drugs.	triphosphoric acid	115-127	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	9-15
28502830-1	2017	Sterile alpha motif and histidine/aspartic acid domain-containing protein 1 (SAMHD1) is a (deoxy)guanosine triphosphate (dGTP/GTP)-activated deoxyribonucleoside triphosphate (dNTP) triphosphohydrolase involved in cellular dNTP homoeostasis.	triphosphoric acid	107-119	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-75
28502830-1	2017	Sterile alpha motif and histidine/aspartic acid domain-containing protein 1 (SAMHD1) is a (deoxy)guanosine triphosphate (dGTP/GTP)-activated deoxyribonucleoside triphosphate (dNTP) triphosphohydrolase involved in cellular dNTP homoeostasis.	triphosphoric acid	107-119	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	77-83
28412183-2	2017	Some have hypothesized that the active metabolites of toxic ribonucleoside analogs, the triphosphate forms, inadvertently target human mitochondrial RNA polymerase (POLRMT), thus inhibiting mitochondrial RNA transcription and protein synthesis.	triphosphoric acid	88-100	RNA polymerase mitochondrial	Homo sapiens	165-171
28412183-5	2017	We found that efficient substrates and chain terminators of POLRMT, such as the nucleoside triphosphate forms of R1479, NITD-008, and INX-08189, are likely to cause mitochondrial toxicity in cells, while weaker chain terminators and inhibitors of POLRMT such as T-705 ribonucleoside triphosphate do not elicit strong in vitro mitochondrial effects.	triphosphoric acid	91-103	RNA polymerase mitochondrial	Homo sapiens	60-66
28412183-5	2017	We found that efficient substrates and chain terminators of POLRMT, such as the nucleoside triphosphate forms of R1479, NITD-008, and INX-08189, are likely to cause mitochondrial toxicity in cells, while weaker chain terminators and inhibitors of POLRMT such as T-705 ribonucleoside triphosphate do not elicit strong in vitro mitochondrial effects.	triphosphoric acid	91-103	RNA polymerase mitochondrial	Homo sapiens	247-253
28035004-6	2017	These structures based on high quality data showed that the base moieties of two substrates are located on the similar but not the same position in the substrate binding pocket and adopt a different hydrogen-bonding pattern, and both triphosphate moieties bind to the hMTH1 Nudix motif (i.e. the hydrolase motif) similarly and align for the hydrolysis reaction.	triphosphoric acid	234-246	nudix hydrolase 1	Homo sapiens	268-273
28223679-6	2017	The new triphosphate derivatives 9 and 10 were considered as the new GPR17 ligands.	triphosphoric acid	8-20	G protein-coupled receptor 17	Homo sapiens	69-74
28505172-1	2017	Nucleoside diphosphate kinase (NDK), which has the same sequence as oncoprotein (OP) in humans, can induce nucleoside triphosphates in DNA replication by maintenance of the deoxynucleotide triphosphate (dNTP"s) and is known to be regulated by viral infection in the shrimp Litopenaeus vannamei.	triphosphoric acid	118-130	cytidine/uridine monophosphate kinase 2	Homo sapiens	0-29
28505172-1	2017	Nucleoside diphosphate kinase (NDK), which has the same sequence as oncoprotein (OP) in humans, can induce nucleoside triphosphates in DNA replication by maintenance of the deoxynucleotide triphosphate (dNTP"s) and is known to be regulated by viral infection in the shrimp Litopenaeus vannamei.	triphosphoric acid	118-130	cytidine/uridine monophosphate kinase 2	Homo sapiens	31-34
27918990-5	2017	Critically, in vitro gene silencing experiments revealed that all of the TPP-containing NPs showed excellent efficiency in inhibiting the mRNA expression level of TNF-alpha (by approximately 85-92%, which was much higher than that obtained using Oligofectamine/siTNF complexes).	triphosphoric acid	73-76	tumor necrosis factor	Mus musculus	163-172
27991919-4	2017	SAMHD1 is a deoxynucleoside triphosphate (dNTP) triphosphohydrolase that cleaves physiological dNTPs into deoxyribonucleosides and inorganic triphosphate.	triphosphoric acid	131-153	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
27498344-4	2016	We generated two triphosphate-conjugated siRNAs targeting uPAR (ppp-uPAR) by in vitro transcription.	triphosphoric acid	17-29	plasminogen activator, urokinase receptor	Homo sapiens	58-62
28092942-2	2017	Time-dependent X-ray crystallography has been successfully applied to view the bypass of 8-oxo-7,8-dihydro-2"-deoxyguanine (8-oxoG), a major oxidative DNA lesion, and the incorporation of the triphosphate form, 8-oxo-dGTP, catalyzed by human DNA polymerase beta.	triphosphoric acid	192-204	DNA polymerase beta	Homo sapiens	242-261
28046007-1	2017	SAMHD1 hydrolyzes 2"-deoxynucleoside-5"-triphosphates (dNTPs) into 2"-deoxynucleosides and inorganic triphosphate products.	triphosphoric acid	91-113	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
27959534-3	2017	Here, by using the triphosphates of chain-terminating antiviral drugs lamivudine ((-)3TC-TP) and emtricitabine ((-)FTC-TP), we structurally reveal the correct sequence of post-chemistry steps during nucleotide incorporation by human DNA polymerase beta (hPolbeta) and provide a structural basis for PPi release.	triphosphoric acid	19-32	DNA polymerase beta	Homo sapiens	233-252
27959534-3	2017	Here, by using the triphosphates of chain-terminating antiviral drugs lamivudine ((-)3TC-TP) and emtricitabine ((-)FTC-TP), we structurally reveal the correct sequence of post-chemistry steps during nucleotide incorporation by human DNA polymerase beta (hPolbeta) and provide a structural basis for PPi release.	triphosphoric acid	19-32	DNA polymerase beta	Homo sapiens	254-262
27756891-5	2016	mRNA cap formation initiates with the linkage of inverted guanosine via a triphosphate bridge to the first transcribed nucleotide, catalysed by mRNA capping enzyme (CE/RNGTT).	triphosphoric acid	74-86	RNA guanylyltransferase and 5'-phosphatase	Homo sapiens	168-173
27498344-4	2016	We generated two triphosphate-conjugated siRNAs targeting uPAR (ppp-uPAR) by in vitro transcription.	triphosphoric acid	17-29	plasminogen activator, urokinase receptor	Homo sapiens	68-72
27915293-3	2016	Our structural analysis revealed a pre-activation state of NS3 helicase in complex with GTPgammaS, in which the triphosphate adopts a compact conformation in the absence of any divalent metal ions.	triphosphoric acid	112-124	KRAS proto-oncogene, GTPase	Homo sapiens	59-62
27645237-6	2016	The active triphosphate metabolite of compound 1, compound 2, does not inhibit human alpha, beta, or gamma DNA polymerases but was a substrate for incorporation by the human mitochondrial RNA polymerase (POLRMT).	triphosphoric acid	11-23	RNA polymerase mitochondrial	Homo sapiens	204-210
27325794-6	2016	Moreover, DCTPP1 hydrolyses the triphosphate form of decitabine with similar kinetic efficiency to its natural substrate dCTP and prevents decitabine-induced global DNA demethylation.	triphosphoric acid	32-44	dCTP pyrophosphatase 1	Homo sapiens	10-16
27606816-2	2016	Insulin NPs were synthesised by an ionic gelation technique using N-di methyl ethyl chitosan cysteine (DMEC-Cys) as permeation enhancer biopolymer, tripolyphosphate (TPP) and insulin.	triphosphoric acid	148-164	insulin	Homo sapiens	0-7
27606816-2	2016	Insulin NPs were synthesised by an ionic gelation technique using N-di methyl ethyl chitosan cysteine (DMEC-Cys) as permeation enhancer biopolymer, tripolyphosphate (TPP) and insulin.	triphosphoric acid	166-169	insulin	Homo sapiens	0-7
27395035-0	2016	Role of recombinant human erythropoietin loading chitosan-tripolyphosphate nanoparticles in busulfan-induced genotoxicity: Analysis of DNA fragmentation via comet assay in cultured HepG2 cells.	triphosphoric acid	58-74	erythropoietin	Homo sapiens	26-40
27588835-1	2016	The sterile alpha motif (SAM) and histidine-aspartate (HD) domain containing protein 1 (SAMHD1) constitute a triphosphohydrolase that converts deoxyribonucleoside triphosphates (dNTPs) into deoxyribonucleosides and triphosphates.	triphosphoric acid	163-176	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	88-94
27331362-9	2016	RESULTS: Administration of CD47mAb400 to donor livers increased recipient survival and resulted in significant reduction of serum transaminases, bilirubin, triphosphate nick-end labeling staining, caspase-3 activity, oxidative and nitrosative stresses, and proinflammatory cytokine expression of TNF-alpha, IL-6 and IL-1beta.	triphosphoric acid	156-168	CD47 molecule	Homo sapiens	27-31
27387794-2	2016	(2016) determined crystal structures of APH(2"")-Ia in complex with various combinations of aminoglycosides and nucleosides, which compellingly revealed that the catalytic activity of this resistance enzyme is regulated by a conformational change of the triphosphate of GTP, a mechanism previously unknown for antibiotic kinases.	triphosphoric acid	254-266	acylaminoacyl-peptide hydrolase	Homo sapiens	40-43
27177604-0	2016	Ethanol Stimulates Endoplasmic Reticulum Inositol Triphosphate and Sigma Receptors to Promote Withdrawal-Associated Loss of Neuron-Specific Nuclear Protein/Fox-3.	triphosphoric acid	50-62	RNA binding fox-1 homolog 3	Rattus norvegicus	124-155
29337488-3	2016	Herein, we report the development and use of tripolyphosphate (TPP) modified chitosan (CS) nanoparticles loaded with small interfering RNA (siRNA) directed against transforming growth factor beta1 (TGF-beta1), which promotes tumorigenesis in advanced CRC.	triphosphoric acid	45-61	transforming growth factor, beta 1	Mus musculus	164-196
29337488-3	2016	Herein, we report the development and use of tripolyphosphate (TPP) modified chitosan (CS) nanoparticles loaded with small interfering RNA (siRNA) directed against transforming growth factor beta1 (TGF-beta1), which promotes tumorigenesis in advanced CRC.	triphosphoric acid	45-61	transforming growth factor, beta 1	Mus musculus	198-207
29337488-3	2016	Herein, we report the development and use of tripolyphosphate (TPP) modified chitosan (CS) nanoparticles loaded with small interfering RNA (siRNA) directed against transforming growth factor beta1 (TGF-beta1), which promotes tumorigenesis in advanced CRC.	triphosphoric acid	63-66	transforming growth factor, beta 1	Mus musculus	164-196
29337488-3	2016	Herein, we report the development and use of tripolyphosphate (TPP) modified chitosan (CS) nanoparticles loaded with small interfering RNA (siRNA) directed against transforming growth factor beta1 (TGF-beta1), which promotes tumorigenesis in advanced CRC.	triphosphoric acid	63-66	transforming growth factor, beta 1	Mus musculus	198-207
29337488-6	2016	A weight ratio of CS/TPP of 8:1 for particles with TGF- beta1 siRNA loaded at a concentration of 20 muM at pH 7.5 showed good pH-responsive drug release when exposed to a CRC homogenate at pH 6.5.	triphosphoric acid	21-24	transforming growth factor, beta 1	Mus musculus	51-61
26400223-1	2016	Deoxycytidine kinase (dCK) is a critical enzyme involved in intracellular phosphorylation of lamivudine (LAM) to its active triphosphates.	triphosphoric acid	124-137	deoxycytidine kinase	Homo sapiens	0-20
27366782-2	2016	The siRNA-Npr3 loaded chitosan nanoparticles were synthesized using ionotropic gelation method, where the positive charge of the chitosan interacts with the negative charge of STPP and siRNA-Npr3.	triphosphoric acid	176-180	natriuretic peptide receptor 3	Rattus norvegicus	10-14
26400223-1	2016	Deoxycytidine kinase (dCK) is a critical enzyme involved in intracellular phosphorylation of lamivudine (LAM) to its active triphosphates.	triphosphoric acid	124-137	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	22-25
26879218-3	2016	Interestingly, these triphosphates were poor substrates for hMTH1, but exhibited strong competitive inhibition against hMTH1 at nanomolar levels.	triphosphoric acid	21-34	nudix hydrolase 1	Homo sapiens	60-65
32263281-1	2016	Ionic cross-linking of water-soluble chitosan with sodium tripolyphosphate in the presence of recombinant tissue plasminogen activator (rtPA) and magnetite (Fe3O4) nanoparticles could produce rtPA-encapsulated magnetic chitosan nanoparticles (MCNPs-rtPA).	triphosphoric acid	51-74	plasminogen activator, tissue type	Rattus norvegicus	106-134
26879218-3	2016	Interestingly, these triphosphates were poor substrates for hMTH1, but exhibited strong competitive inhibition against hMTH1 at nanomolar levels.	triphosphoric acid	21-34	nudix hydrolase 1	Homo sapiens	119-124
25871850-3	2015	Here we demonstrate that AngII-induces biphasic calcium entry in vascular smooth muscle cells, consisting of an immediate peak due to inositol tris-phosphate-dependent release of intracellular calcium, followed by a sustained transmembrane Ca(2+) influx through store-operated calcium channels (SOCs).	triphosphoric acid	143-157	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	25-30
26792860-3	2016	It was recently discovered that, in contrast to ASMase, SMPDL3A is inactive against sphingomyelin and, surprisingly, can instead hydrolyze nucleoside diphosphates and triphosphates, which may play a role in purinergic signaling.	triphosphoric acid	167-180	sphingomyelin phosphodiesterase, acid-like 3A	Mus musculus	56-63
26438820-1	2015	Sterile alpha-motif/histidine-aspartate domain-containing protein (SAMHD1), a homo-tetrameric GTP/dGTP-dependent dNTP triphosphohydrolase, catalyzes the conversion of dNTP into deoxynucleoside and triphosphate.	triphosphoric acid	197-209	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	67-73
25569307-1	2015	Gel-like coacervates that adhere to both hydrophilic and hydrophobic substrates under water have recently been prepared by ionically cross-linking poly(allylamine) (PAH) with pyrophosphate (PPi) and tripolyphosphate (TPP).	triphosphoric acid	199-215	phenylalanine hydroxylase	Homo sapiens	165-168
25660653-3	2015	Bovine serum albumin (BSA)-loaded chitosan nanoparticles was fabricated based on ionic gelation interaction between chitosan and sodium tripolyphosphate.	triphosphoric acid	129-152	albumin	Homo sapiens	7-20
25938141-2	2015	METHODS: The BMP-2 loaded chitosan nanospheres were prepared using ionic crosslinking method with tripolyphosphate (TPP) and chitosan.	triphosphoric acid	98-114	bone morphogenetic protein 2	Homo sapiens	13-18
25938141-2	2015	METHODS: The BMP-2 loaded chitosan nanospheres were prepared using ionic crosslinking method with tripolyphosphate (TPP) and chitosan.	triphosphoric acid	116-119	bone morphogenetic protein 2	Homo sapiens	13-18
25534683-4	2015	Besides, sodium tripolyphosphate (TPP) was added into TRNC to compromise certain disadvantageous attributes for pDNA delivery.	triphosphoric acid	9-32	mitochondrially encoded tRNA cysteine	Homo sapiens	54-58
25534683-4	2015	Besides, sodium tripolyphosphate (TPP) was added into TRNC to compromise certain disadvantageous attributes for pDNA delivery.	triphosphoric acid	34-37	mitochondrially encoded tRNA cysteine	Homo sapiens	54-58
25569307-1	2015	Gel-like coacervates that adhere to both hydrophilic and hydrophobic substrates under water have recently been prepared by ionically cross-linking poly(allylamine) (PAH) with pyrophosphate (PPi) and tripolyphosphate (TPP).	triphosphoric acid	217-220	phenylalanine hydroxylase	Homo sapiens	165-168
25569307-3	2015	To further analyze their stimulus-responsive properties, we have investigated the pH and ionic strength effects on the formation, rheology and adhesion of PAH/PPi and PAH/TPP complexes.	triphosphoric acid	171-174	phenylalanine hydroxylase	Homo sapiens	167-170
25569307-8	2015	Additionally, the sensitivity of PAH/PPi and PAH/TPP complexes to ionic strength was demonstrated as a potential route to injectable adhesive design (where spontaneous adhesive formation was triggered via injection of low-viscosity, colloidal PAH/TPP dispersions into phosphate buffered saline).	triphosphoric acid	247-250	phenylalanine hydroxylase	Homo sapiens	33-36
25569307-8	2015	Additionally, the sensitivity of PAH/PPi and PAH/TPP complexes to ionic strength was demonstrated as a potential route to injectable adhesive design (where spontaneous adhesive formation was triggered via injection of low-viscosity, colloidal PAH/TPP dispersions into phosphate buffered saline).	triphosphoric acid	247-250	phenylalanine hydroxylase	Homo sapiens	45-48
25569307-8	2015	Additionally, the sensitivity of PAH/PPi and PAH/TPP complexes to ionic strength was demonstrated as a potential route to injectable adhesive design (where spontaneous adhesive formation was triggered via injection of low-viscosity, colloidal PAH/TPP dispersions into phosphate buffered saline).	triphosphoric acid	247-250	phenylalanine hydroxylase	Homo sapiens	45-48
25288789-5	2014	We provide evidence that SMPDL3A is not an acid sphingomyelinase but unexpectedly is active against nucleotide diphosphate and triphosphate substrates at acidic and neutral pH.	triphosphoric acid	127-139	sphingomyelin phosphodiesterase acid like 3A	Homo sapiens	25-32
25209965-6	2015	Studies of the conversion of ddUDP and d4UDP into their triphosphate metabolites by nucleoside diphosphate kinase (NDPK) showed nearly no conversion of either diphosphate, which may be the reason for low intracellular triphosphate levels that result in low antiviral activity.	triphosphoric acid	56-68	cytidine/uridine monophosphate kinase 2	Homo sapiens	84-113
25209965-6	2015	Studies of the conversion of ddUDP and d4UDP into their triphosphate metabolites by nucleoside diphosphate kinase (NDPK) showed nearly no conversion of either diphosphate, which may be the reason for low intracellular triphosphate levels that result in low antiviral activity.	triphosphoric acid	56-68	cytidine/uridine monophosphate kinase 2	Homo sapiens	115-119
25209965-6	2015	Studies of the conversion of ddUDP and d4UDP into their triphosphate metabolites by nucleoside diphosphate kinase (NDPK) showed nearly no conversion of either diphosphate, which may be the reason for low intracellular triphosphate levels that result in low antiviral activity.	triphosphoric acid	218-230	cytidine/uridine monophosphate kinase 2	Homo sapiens	115-119
25205248-2	2015	We have previously noted that stem/progenitor cells in the SVZ and the subgranular layer (SGL) of the dentate gyrus express high levels of plasma membrane-bound nucleoside triphosphate diphosphohydrolase 2 (NTPDase2), an ectoenzyme that hydrolyzes extracellular nucleoside diphosphates and triphosphates.	triphosphoric acid	290-303	ectonucleoside triphosphate diphosphohydrolase 2	Mus musculus	161-205
25205248-2	2015	We have previously noted that stem/progenitor cells in the SVZ and the subgranular layer (SGL) of the dentate gyrus express high levels of plasma membrane-bound nucleoside triphosphate diphosphohydrolase 2 (NTPDase2), an ectoenzyme that hydrolyzes extracellular nucleoside diphosphates and triphosphates.	triphosphoric acid	290-303	ectonucleoside triphosphate diphosphohydrolase 2	Mus musculus	207-215
25490387-1	2015	Duplex RNA harboring the 5"-terminal triphosphate RNA is hypothesized to not only execute selective gene silencing via RNA interference, but also induce type I interferon (IFN) through activation of the retinoic acid inducible gene I (RIG-I).	triphosphoric acid	37-49	interferon alpha 1	Homo sapiens	153-176
25490387-1	2015	Duplex RNA harboring the 5"-terminal triphosphate RNA is hypothesized to not only execute selective gene silencing via RNA interference, but also induce type I interferon (IFN) through activation of the retinoic acid inducible gene I (RIG-I).	triphosphoric acid	37-49	DExD/H-box helicase 58	Homo sapiens	203-233
25490387-1	2015	Duplex RNA harboring the 5"-terminal triphosphate RNA is hypothesized to not only execute selective gene silencing via RNA interference, but also induce type I interferon (IFN) through activation of the retinoic acid inducible gene I (RIG-I).	triphosphoric acid	37-49	DExD/H-box helicase 58	Homo sapiens	235-240
24867973-3	2014	We report here that SAMHD1 cleaves NRTI triphosphates (TPs) at significantly lower rates than dNTPs and that SAMHD1 depletion from monocytic cells affects the susceptibility of HIV-1 infections to NRTIs in complex ways that depend not only on the relative changes in dNTP and NRTI-TP concentrations but also on the NRTI activation pathways.	triphosphoric acid	55-58	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	20-26
24867973-3	2014	We report here that SAMHD1 cleaves NRTI triphosphates (TPs) at significantly lower rates than dNTPs and that SAMHD1 depletion from monocytic cells affects the susceptibility of HIV-1 infections to NRTIs in complex ways that depend not only on the relative changes in dNTP and NRTI-TP concentrations but also on the NRTI activation pathways.	triphosphoric acid	55-57	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	20-26
24991938-0	2014	Triphosphate induced dimerization of human guanylate binding protein 1 involves association of the C-terminal helices: a joint double electron-electron resonance and FRET study.	triphosphoric acid	0-12	guanylate binding protein 1	Homo sapiens	43-70
24768406-2	2014	The chitosan/tripolyphosphate microspheres encapsulated with MGF-Ct24E (CS/TPP/MGF-Ct24E) are prepared using emulsion-ionic cross-linking method in order to achieve the sustained release and preserve the bioactivity of MGF-Ct24E.	triphosphoric acid	13-29	kit ligand	Mus musculus	61-64
24768406-2	2014	The chitosan/tripolyphosphate microspheres encapsulated with MGF-Ct24E (CS/TPP/MGF-Ct24E) are prepared using emulsion-ionic cross-linking method in order to achieve the sustained release and preserve the bioactivity of MGF-Ct24E.	triphosphoric acid	13-29	kit ligand	Mus musculus	79-82
24768406-2	2014	The chitosan/tripolyphosphate microspheres encapsulated with MGF-Ct24E (CS/TPP/MGF-Ct24E) are prepared using emulsion-ionic cross-linking method in order to achieve the sustained release and preserve the bioactivity of MGF-Ct24E.	triphosphoric acid	13-29	kit ligand	Mus musculus	79-82
24878662-2	2014	Recent crystal structures of the zebrafish P2X4 (zfP2X4) receptor reveal a large ATP-binding pocket (ABP) located at the subunit interface of zfP2X4 receptors, which is occupied by a conspicuous cluster of basic residues to recognize triphosphate moiety of ATP.	triphosphoric acid	234-246	purinergic receptor P2X, ligand-gated ion channel, 4a	Danio rerio	43-47
24901528-0	2014	Selective isolation of trypsin inhibitor and lectin from soybean whey by chitosan/tripolyphosphate/genipin co-crosslinked beads.	triphosphoric acid	82-98	LOW QUALITY PROTEIN: lectin	Glycine max	45-51
24878662-2	2014	Recent crystal structures of the zebrafish P2X4 (zfP2X4) receptor reveal a large ATP-binding pocket (ABP) located at the subunit interface of zfP2X4 receptors, which is occupied by a conspicuous cluster of basic residues to recognize triphosphate moiety of ATP.	triphosphoric acid	234-246	purinergic receptor P2X, ligand-gated ion channel, 4a	Danio rerio	49-55
24878662-2	2014	Recent crystal structures of the zebrafish P2X4 (zfP2X4) receptor reveal a large ATP-binding pocket (ABP) located at the subunit interface of zfP2X4 receptors, which is occupied by a conspicuous cluster of basic residues to recognize triphosphate moiety of ATP.	triphosphoric acid	234-246	purinergic receptor P2X, ligand-gated ion channel, 4a	Danio rerio	142-148
24878662-4	2014	The open crystal structure of zfP2X4 confirms one of three AR modes (named AR1), in which the adenine ring of ATP is buried into site S1 while the triphosphate moiety interacts with clustered basic residues.	triphosphoric acid	147-159	purinergic receptor P2X, ligand-gated ion channel, 4a	Danio rerio	30-36
24878662-4	2014	The open crystal structure of zfP2X4 confirms one of three AR modes (named AR1), in which the adenine ring of ATP is buried into site S1 while the triphosphate moiety interacts with clustered basic residues.	triphosphoric acid	147-159	cytochrome P450, family 19, subfamily A, polypeptide 1a	Danio rerio	75-78
24638093-9	2014	This approach has recently demonstrated that membrane-delimited signaling involving cross-talk between inositol (1,4,5)-triphosphate receptor (IP3R) and RyR contributes to Ca(2+) spark activation in skeletal muscle.	triphosphoric acid	118-132	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	143-147
24753578-1	2014	The HIV-1 restriction factor sterile alpha-motif/histidine-aspartate domain-containing protein 1 (SAMHD1) is a tetrameric protein that catalyzes the hydrolysis of all dNTPs to the deoxynucleoside and tripolyphosphate, which effectively depletes the dNTP substrates of HIV reverse transcriptase.	triphosphoric acid	200-216	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	98-104
24586273-8	2014	hiPSC-derived neurons exhibited inositol tri-phosphate (IP3) receptor-dependent release of intracellular calcium from the endoplasmic reticulum in neuronal processes as calcium waves propagating from apical and distal dendrites, and in the soma.	triphosphoric acid	41-54	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	56-69
24124444-12	2013	Our results suggest that Ham1p could have a broader specificity that includes 5-FUTP and other pyrimidine analogoue triphosphates.	triphosphoric acid	116-129	nucleoside triphosphate pyrophosphohydrolase HAM1	Saccharomyces cerevisiae S288C	25-30
24021036-7	2013	We propose that inorganic tripolyphosphate, the simplest triphosphate compound, is the primitive substrate of CYTH proteins, other enzyme activities, such as adenylate cyclase (in A. hydrophila and Yersinia pestis), mRNA triphosphatase (in fungi and protozoans), and ThTPase (in metazoans), being secondary acquisitions.	triphosphoric acid	26-42	thiamine triphosphatase	Homo sapiens	267-274
24021036-7	2013	We propose that inorganic tripolyphosphate, the simplest triphosphate compound, is the primitive substrate of CYTH proteins, other enzyme activities, such as adenylate cyclase (in A. hydrophila and Yersinia pestis), mRNA triphosphatase (in fungi and protozoans), and ThTPase (in metazoans), being secondary acquisitions.	triphosphoric acid	57-69	thiamine triphosphatase	Homo sapiens	267-274
23792655-2	2014	Ovalbumin (OVA) or gp100 (melanocyte-associated antigen gp100 protein)-loaded CS-sodium tripolyphosphate (TPP)-grafted NPs were prepared by crosslinking low-molecular-weight CS with TPP.	triphosphoric acid	81-104	premelanosome protein	Mus musculus	19-24
23792655-2	2014	Ovalbumin (OVA) or gp100 (melanocyte-associated antigen gp100 protein)-loaded CS-sodium tripolyphosphate (TPP)-grafted NPs were prepared by crosslinking low-molecular-weight CS with TPP.	triphosphoric acid	81-104	premelanosome protein	Mus musculus	56-61
23792655-2	2014	Ovalbumin (OVA) or gp100 (melanocyte-associated antigen gp100 protein)-loaded CS-sodium tripolyphosphate (TPP)-grafted NPs were prepared by crosslinking low-molecular-weight CS with TPP.	triphosphoric acid	106-109	premelanosome protein	Mus musculus	19-24
23820013-6	2013	In vitro gene silencing experiments revealed that TPP-PPM/TNF-alpha siRNA NPs with a weight ratio of 40:1 showed the most efficient inhibition of the expression and secretion of TNF-alpha (approximately 69.9%, which was comparable to the 71.4% obtained using OF/siRNA NPs), and its RNAi efficiency was highly inhibited in the presence of mannose (20 mm).	triphosphoric acid	50-53	tumor necrosis factor	Homo sapiens	58-67
23820013-6	2013	In vitro gene silencing experiments revealed that TPP-PPM/TNF-alpha siRNA NPs with a weight ratio of 40:1 showed the most efficient inhibition of the expression and secretion of TNF-alpha (approximately 69.9%, which was comparable to the 71.4% obtained using OF/siRNA NPs), and its RNAi efficiency was highly inhibited in the presence of mannose (20 mm).	triphosphoric acid	50-53	tumor necrosis factor	Homo sapiens	178-187
23820013-7	2013	Finally, TPP-PPM/siRNA NPs showed potential therapeutic effects on colitis tissues, remarkably reducing TNF-alpha level.	triphosphoric acid	9-12	tumor necrosis factor	Homo sapiens	104-113
23880768-1	2013	SAMHD1 (SAM domain- and HD domain-containing protein 1) is a dGTP-dependent dNTP triphosphohydrolase that converts dNTPs into deoxyribonucleosides and triphosphates.	triphosphoric acid	151-164	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
23880768-1	2013	SAMHD1 (SAM domain- and HD domain-containing protein 1) is a dGTP-dependent dNTP triphosphohydrolase that converts dNTPs into deoxyribonucleosides and triphosphates.	triphosphoric acid	151-164	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	8-54
24273643-2	2013	Two of the analogues bear a methylene modification in the triphosphate bridge, providing resistance against either the Dcp2 or DcpS decapping enzymes.	triphosphoric acid	58-70	decapping mRNA 2	Homo sapiens	119-123
23419643-6	2013	The in vitro and in vivo gene knockdown measurement showed that siMap4k4 loaded GTC/TPP NPs effectively inhibited TNF-alpha production, which remarkably outperformed siMap4k4 loaded TC/TPP NPs.	triphosphoric acid	84-87	tumor necrosis factor	Homo sapiens	114-123
23416111-7	2013	Interestingly, in addition to the diphosphate products, a nucleoside diphosphate kinase (NDPK) activity was also present with subsequent triphosphates formed.	triphosphoric acid	137-150	cytidine/uridine monophosphate kinase 2	Homo sapiens	58-87
23416111-7	2013	Interestingly, in addition to the diphosphate products, a nucleoside diphosphate kinase (NDPK) activity was also present with subsequent triphosphates formed.	triphosphoric acid	137-150	cytidine/uridine monophosphate kinase 2	Homo sapiens	89-93
23685671-2	2013	Their mutagenicity is believed to result from a conformational shift of the N9-C1" glycosidic bonds from anti to syn, which allows the lesions to form noncanonical Hoogsteen-type base pairs with incoming triphosphates during DNA replication.	triphosphoric acid	204-217	synemin	Homo sapiens	113-116
23338611-3	2013	By introducing a triphosphate group at the 5" end of siRNA (ppp-siRNA), gene silencing can be combined with immune activation via the cytosolic helicase retinoic acid-inducible gene I (RIG-I), a ubiquitously expressed receptor recognizing viral RNA.	triphosphoric acid	17-29	DEAD/H box helicase 58	Mus musculus	185-190
23271435-6	2013	The purpose of this study was to prepare chitosan nanoparticles via ionic gelation of chitosan by tripolyphosphate for effective delivery of siRNA to silence the anti-apoptotic Bcl-2 gene in neoplastic cells.	triphosphoric acid	98-114	BCL2 apoptosis regulator	Homo sapiens	177-182
24273643-2	2013	Two of the analogues bear a methylene modification in the triphosphate bridge, providing resistance against either the Dcp2 or DcpS decapping enzymes.	triphosphoric acid	58-70	decapping enzyme, scavenger	Homo sapiens	127-131
24273643-7	2013	Transcripts containing fluorescent caps but unmodified in the triphosphate chain are hydrolysed by Dcp2 whereas those containing a alpha-beta methylene modification are resistant.	triphosphoric acid	62-74	decapping mRNA 2	Homo sapiens	99-103
22526308-9	2012	The resulting monophosphate was consecutively phosphorylated to the diphosphate and to the triphosphate PSI-352666 by guanylate kinase 1 and nucleoside diphosphate kinase, respectively.	triphosphoric acid	91-103	guanylate kinase 1	Homo sapiens	118-136
22912486-0	2012	Mechanistic characterization of the 5"-triphosphate-dependent activation of PKR: lack of 5"-end nucleobase specificity, evidence for a distinct triphosphate binding site, and a critical role for the dsRBD.	triphosphoric acid	39-51	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	76-79
22912486-8	2012	Activation experiments reveal that short dsRNAs compete with 5"-triphosphate RNAs and heparin for activation, and likewise gel-shift assays reveal that activating 5"-triphosphate RNAs and heparin compete with short dsRNAs for binding to PKR"s dsRBD.	triphosphoric acid	64-76	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	237-240
22912486-11	2012	Overall, 5"-triphosphate-containing, weakly structured RNAs activate PKR via interactions with both the dsRBD and a distinct triphosphate binding site that lacks 5"-nucleobase specificity, allowing the innate immune response to provide broad-spectrum protection from pathogens.	triphosphoric acid	12-24	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	69-72
22580055-0	2012	Methylenebisphosphonate and triphosphate derivatives of the mevalonate pathway are substrates of yeast UTP:glucose-1-phosphate uridylyltransferase.	triphosphoric acid	28-40	UTP glucose-1-phosphate uridylyltransferase	Saccharomyces cerevisiae S288C	103-146
22526308-9	2012	The resulting monophosphate was consecutively phosphorylated to the diphosphate and to the triphosphate PSI-352666 by guanylate kinase 1 and nucleoside diphosphate kinase, respectively.	triphosphoric acid	91-103	cytidine/uridine monophosphate kinase 1	Homo sapiens	141-170
22384212-5	2012	We studied the cellular function of ITPA in HeLa cells using the purine analog 6-N hydroxylaminopurine (HAP), whose triphosphate is also a substrate for ITPA.	triphosphoric acid	116-128	inosine triphosphatase	Homo sapiens	36-40
22378652-8	2012	The adenine ring, wedged between beta1 and beta13, acts as a fulcrum for the beta14 lever, turning a modest closure around the triphosphate group into significant opening of the pre-TM2 loop.	triphosphoric acid	127-139	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	33-49
22429303-3	2012	This property of Mg2+ also helps the stabilization of diphosphate and triphosphate groups of nucleotides, as well as promoting the condensation of orthophosphate to oligophosphates, like pyrophosphate and trimetaphosphate.	triphosphoric acid	70-82	mucin 7, secreted	Homo sapiens	17-20
22384212-5	2012	We studied the cellular function of ITPA in HeLa cells using the purine analog 6-N hydroxylaminopurine (HAP), whose triphosphate is also a substrate for ITPA.	triphosphoric acid	116-128	inosine triphosphatase	Homo sapiens	153-157
22001532-7	2011	The NGF encapsulation efficiency ranged from 63% to 88% depending on the concentration of STPP.	triphosphoric acid	90-94	nerve growth factor	Rattus norvegicus	4-7
22001532-8	2011	The in vitro release profiles of NGF from NGF-CMSs were influenced by the concentration of STPP.	triphosphoric acid	91-95	nerve growth factor	Rattus norvegicus	33-36
22001532-8	2011	The in vitro release profiles of NGF from NGF-CMSs were influenced by the concentration of STPP.	triphosphoric acid	91-95	nerve growth factor	Rattus norvegicus	42-45
22001532-9	2011	NGF-CMSs which were cross-linked with higher concentration of STPP showed slower but sustained release of NGF.	triphosphoric acid	62-66	nerve growth factor	Rattus norvegicus	0-3
22001532-9	2011	NGF-CMSs which were cross-linked with higher concentration of STPP showed slower but sustained release of NGF.	triphosphoric acid	62-66	nerve growth factor	Rattus norvegicus	106-109
22056990-5	2011	Here we show that human SAMHD1 is a potent dGTP-stimulated triphosphohydrolase that converts deoxynucleoside triphosphates to the constituent deoxynucleoside and inorganic triphosphate.	triphosphoric acid	162-184	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	24-30
22111974-2	2011	Chitosan-thioglycolic acid (chitosan-TGA) nanoparticles (NP) were formed via ionic gelation with tripolyphosphate (TPP).	triphosphoric acid	97-113	T-box transcription factor 1	Homo sapiens	37-40
22111974-2	2011	Chitosan-thioglycolic acid (chitosan-TGA) nanoparticles (NP) were formed via ionic gelation with tripolyphosphate (TPP).	triphosphoric acid	115-118	T-box transcription factor 1	Homo sapiens	37-40
21600932-8	2011	Nucleoside diphosphate kinase is the primary enzyme involved in phosphorylation of the diphosphate to the active triphosphate, PSI-352666.	triphosphoric acid	113-125	cytidine/uridine monophosphate kinase 2	Homo sapiens	0-29
21807195-3	2011	The results show that TPP in kaolinite clay plays an important role in the accumulation process of Pb(II) on the modified electrode surface.	triphosphoric acid	22-25	submaxillary gland androgen regulated protein 3B	Homo sapiens	99-105
21454646-4	2011	Here, we present crystal structures of the Leishmania major dUTPase in complex with substrate analogues, the product dUMP and a substrate fragment, and of the homologous Campylobacter jejuni dUTPase in complex with a triphosphate substrate analogue.	triphosphoric acid	217-229	Deoxyuridine triphosphatase	Drosophila melanogaster	60-67
21628579-4	2011	Its mode of cytotoxicity is thought to be associated in part with the triphosphate functioning as an allosteric inhibitor of hRNR.	triphosphoric acid	70-82	nuclear receptor subfamily 2 group E member 3	Homo sapiens	125-129
21576373-1	2011	Cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel belonging to the adenosine triphosphate (ATP)-binding cassette (ABC) superfamily.	triphosphoric acid	108-120	CF transmembrane conductance regulator	Homo sapiens	0-51
21576373-1	2011	Cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel belonging to the adenosine triphosphate (ATP)-binding cassette (ABC) superfamily.	triphosphoric acid	108-120	CF transmembrane conductance regulator	Homo sapiens	53-57
21454646-4	2011	Here, we present crystal structures of the Leishmania major dUTPase in complex with substrate analogues, the product dUMP and a substrate fragment, and of the homologous Campylobacter jejuni dUTPase in complex with a triphosphate substrate analogue.	triphosphoric acid	217-229	Deoxyuridine triphosphatase	Drosophila melanogaster	191-198
21417463-7	2011	The triphosphate modifications were much better tolerated by P2Y(2), and in some cases also by P2Y(6), than by P2Y(4) receptors.	triphosphoric acid	4-16	purinergic receptor P2Y2	Homo sapiens	61-67
21417463-7	2011	The triphosphate modifications were much better tolerated by P2Y(2), and in some cases also by P2Y(6), than by P2Y(4) receptors.	triphosphoric acid	4-16	pyrimidinergic receptor P2Y6	Homo sapiens	95-101
20600405-9	2010	Nasal administration of TMC/CpG/OVA and TMC/TPP/OVA to mice resulted in comparable serum IgG levels (ca.	triphosphoric acid	44-47	immunoglobulin heavy chain (V7183 family)	Mus musculus	89-92
20641989-13	2004	3"-(Ethynyl)uridine is phosphorylated rapidly with UCK2 to its triphosphate, which blocks RNA synthesis by inhibition of RNA polymerase (8, 9).	triphosphoric acid	63-75	uridine-cytidine kinase 2	Homo sapiens	51-55
20600405-5	2010	To design a nasal antigen delivery system capable of inducing stronger Th1 type responses, TPP as a crosslinking agent was replaced by unmethylated CpG DNA, a TLR-9 ligand and a potent inducer of Th1 responses, to prepare ovalbumin (OVA) loaded TMC nanoparticles (TMC/CpG/OVA).	triphosphoric acid	91-94	negative elongation factor complex member C/D, Th1l	Mus musculus	196-199
20674156-2	2010	The resulting new CTS-ECH-TPP adsorbent was characterized by CHN analysis, EDS, FTIR spectroscopy, TGA and DSC, and the adsorption and desorption of Cu(II), Cd(II) and Pb(II) ions in aqueous solution were investigated.	triphosphoric acid	26-29	T-box transcription factor 1	Homo sapiens	99-102
20801890-11	2010	PSI-7411 is then consecutively phosphorylated to the diphosphate, PSI-7410, and to the active triphosphate metabolite, PSI-7409, by UMP-CMP kinase and nucleoside diphosphate kinase, respectively.	triphosphoric acid	94-106	cytidine/uridine monophosphate kinase 2	Homo sapiens	132-146
20936128-2	2010	Human inosine triphosphate pyrophosphatase (ITPA) hydrolyzes triphosphates of noncanonical purine bases (i.e., ITP, dITP, XTP, dXTP, or their mimic: 6-hydroxyaminopurine (HAP) deoxynucleoside triphosphate) and thus regulates nucleotide pools and protects cells from DNA damage.	triphosphoric acid	61-74	inosine triphosphatase	Homo sapiens	6-42
20936128-2	2010	Human inosine triphosphate pyrophosphatase (ITPA) hydrolyzes triphosphates of noncanonical purine bases (i.e., ITP, dITP, XTP, dXTP, or their mimic: 6-hydroxyaminopurine (HAP) deoxynucleoside triphosphate) and thus regulates nucleotide pools and protects cells from DNA damage.	triphosphoric acid	61-74	inosine triphosphatase	Homo sapiens	44-48
20652459-5	2010	Thus, overall the CS/PEG beads crosslinked with TPP and GD look to be a promising and novel alternative gastrointestinal drug release system.	triphosphoric acid	48-51	progestagen associated endometrial protein	Homo sapiens	21-24
20044203-0	2010	Adsorption characterization of Pb(II) and Cu(II) ions onto chitosan-tripolyphosphate beads: Kinetic, equilibrium and thermodynamic studies.	triphosphoric acid	68-84	submaxillary gland androgen regulated protein 3B	Homo sapiens	31-48
20065942-2	2010	TMPK also mediates phosphorylation of monophosphates of thymidine nucleoside analog (NA) prodrugs on the pathway to their active triphosphate antiviral or antitumor moieties.	triphosphoric acid	129-141	deoxythymidylate kinase	Mus musculus	0-4
19765547-8	2010	However, down-regulating UMP/CMPK expression by siRNA led to a decrease in the formation of the triphosphate metabolites, resulting in cellular resistance to these analogs.	triphosphoric acid	96-108	cytidine/uridine monophosphate kinase 1	Homo sapiens	25-33
19765547-9	2010	More diphosphate and triphosphate metabolites of deoxycytidine analogs were detected and cellular sensitivity to these agents was increased in the UMP/CMPK-overexpressing cells.	triphosphoric acid	21-33	cytidine/uridine monophosphate kinase 1	Homo sapiens	147-150
19765547-9	2010	More diphosphate and triphosphate metabolites of deoxycytidine analogs were detected and cellular sensitivity to these agents was increased in the UMP/CMPK-overexpressing cells.	triphosphoric acid	21-33	cytidine/uridine monophosphate kinase 1	Homo sapiens	151-155
19839790-2	2009	Thus, in this study, insulin-loaded NOCC nanoparticles were prepared by ionic gelation of NOCC with TPP (tripolyphosphate).	triphosphoric acid	100-103	insulin	Homo sapiens	21-28
20587852-7	2010	The dCyd analogues were both phosphorylated in perfused heart to the triphosphate, but only at the limit of detection and they were not phosphorylated in isolated mitochondria.	triphosphoric acid	69-81	Cyd	Drosophila melanogaster	4-8
19836424-4	2010	Here we report that ATP, other nucleoside triphosphates and sodium triphosphate protect FGF2 from trypsin, plasmin and neutrophile elastase digestion in vitro.	triphosphoric acid	60-79	fibroblast growth factor 2	Homo sapiens	88-92
19836424-4	2010	Here we report that ATP, other nucleoside triphosphates and sodium triphosphate protect FGF2 from trypsin, plasmin and neutrophile elastase digestion in vitro.	triphosphoric acid	60-79	plasminogen	Homo sapiens	107-114
19926722-5	2010	hTgs1 utilizes a broad range of m(7)G nucleotides, including mono-, di-, tri-, and tetraphosphate derivatives as well as cap dinucleotides with triphosphate or tetraphosphate bridges.	triphosphoric acid	144-156	trimethylguanosine synthase 1	Homo sapiens	0-5
19836424-11	2010	For the first time these data demonstrate protection of FGF2 by bound ATP, other nucleoside triphosphates or sodium triphosphate from rapid protease digestion.	triphosphoric acid	109-128	fibroblast growth factor 2	Homo sapiens	56-60
19839790-2	2009	Thus, in this study, insulin-loaded NOCC nanoparticles were prepared by ionic gelation of NOCC with TPP (tripolyphosphate).	triphosphoric acid	105-121	insulin	Homo sapiens	21-28
19839790-5	2009	Furthermore, the cumulative release of insulin from insulin-loaded NOCC nanoparticles decreased with decreasing NOCC-to-TPP weight ratio, but it increased with decreasing the initial concentration of insulin.	triphosphoric acid	120-123	insulin	Homo sapiens	39-46
19839790-5	2009	Furthermore, the cumulative release of insulin from insulin-loaded NOCC nanoparticles decreased with decreasing NOCC-to-TPP weight ratio, but it increased with decreasing the initial concentration of insulin.	triphosphoric acid	120-123	insulin	Homo sapiens	52-59
19839790-5	2009	Furthermore, the cumulative release of insulin from insulin-loaded NOCC nanoparticles decreased with decreasing NOCC-to-TPP weight ratio, but it increased with decreasing the initial concentration of insulin.	triphosphoric acid	120-123	insulin	Homo sapiens	52-59
19545119-4	2009	Insulin, taken as a model peptide, was associated to CS-TPP-ALG nanoparticles with efficiencies in the range of ~41 to ~52%, irrespective of the M(w) of the ALG incorporated in the formulation.	triphosphoric acid	56-59	insulin	Oryctolagus cuniculus	0-7
19570917-5	2009	Furthermore, fos-1 and jun-1 regulate the spermathecal-specific expression of plc-1, a gene that encodes a phospholipase C (PLC) isozyme that is rate-limiting for inositol triphosphate production and ovulation, and overexpression of PLC-1 rescues the ovulation defect in fos-1(RNAi) worms.	triphosphoric acid	172-184	Transcription factor fos-1	Caenorhabditis elegans	13-18
19570917-5	2009	Furthermore, fos-1 and jun-1 regulate the spermathecal-specific expression of plc-1, a gene that encodes a phospholipase C (PLC) isozyme that is rate-limiting for inositol triphosphate production and ovulation, and overexpression of PLC-1 rescues the ovulation defect in fos-1(RNAi) worms.	triphosphoric acid	172-184	BZIP domain-containing protein;Transcription factor jun-1	Caenorhabditis elegans	23-28
19570917-5	2009	Furthermore, fos-1 and jun-1 regulate the spermathecal-specific expression of plc-1, a gene that encodes a phospholipase C (PLC) isozyme that is rate-limiting for inositol triphosphate production and ovulation, and overexpression of PLC-1 rescues the ovulation defect in fos-1(RNAi) worms.	triphosphoric acid	172-184	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1;PhosphoLipase C;Phosphoinositide phospholipase C	Caenorhabditis elegans	78-83
19570917-5	2009	Furthermore, fos-1 and jun-1 regulate the spermathecal-specific expression of plc-1, a gene that encodes a phospholipase C (PLC) isozyme that is rate-limiting for inositol triphosphate production and ovulation, and overexpression of PLC-1 rescues the ovulation defect in fos-1(RNAi) worms.	triphosphoric acid	172-184	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1;PhosphoLipase C;Phosphoinositide phospholipase C	Caenorhabditis elegans	233-238
19570917-5	2009	Furthermore, fos-1 and jun-1 regulate the spermathecal-specific expression of plc-1, a gene that encodes a phospholipase C (PLC) isozyme that is rate-limiting for inositol triphosphate production and ovulation, and overexpression of PLC-1 rescues the ovulation defect in fos-1(RNAi) worms.	triphosphoric acid	172-184	Transcription factor fos-1	Caenorhabditis elegans	271-276
19545119-5	2009	These CS-TPP-ALG nanoparticles exhibited a capacity to enhance the systemic absorption of insulin after nasal administration to conscious rabbits.	triphosphoric acid	9-12	insulin	Oryctolagus cuniculus	90-97
19576794-2	2009	The cytosolic helicase RIG-I is a key sensor of viral infections and is activated by RNA containing a triphosphate at the 5" end.	triphosphoric acid	102-114	DExD/H-box helicase 58	Homo sapiens	23-28
19576794-8	2009	These results define the structure of RNA for full RIG-I activation and explain how RIG-I detects negative-strand RNA viruses that lack long double-stranded RNA but do contain blunt short double-stranded 5" triphosphate RNA in the panhandle region of their single-stranded genome.	triphosphoric acid	207-219	DExD/H-box helicase 58	Homo sapiens	51-56
19576794-8	2009	These results define the structure of RNA for full RIG-I activation and explain how RIG-I detects negative-strand RNA viruses that lack long double-stranded RNA but do contain blunt short double-stranded 5" triphosphate RNA in the panhandle region of their single-stranded genome.	triphosphoric acid	207-219	DExD/H-box helicase 58	Homo sapiens	84-89
18817821-3	2008	FT-IR and XRD results indicated that the spontaneous interaction between CS, insulin, gamma-PGA, MgSO(4) and TPP can form an ionically crosslinked network-structure, leading to the formation of nanoparticles.	triphosphoric acid	109-112	insulin	Homo sapiens	77-84
19087190-0	2009	Reversible tetramerization of human TK1 to the high catalytic efficient form is induced by pyrophosphate, in addition to tripolyphosphates, or high enzyme concentration.	triphosphoric acid	121-138	thymidine kinase 1	Homo sapiens	36-39
19246988-8	2009	It is stabilized by mono-methylation of its 5"-triphosphate group and binding of a specific La-Related protein, LARP7 at its 3" end.	triphosphoric acid	47-59	La ribonucleoprotein 7, transcriptional regulator	Homo sapiens	112-117
19173657-0	2009	Competitive inhibition of uracil DNA glycosylase by a modified nucleotide whose triphosphate is a substrate for DNA polymerase.	triphosphoric acid	80-92	DNA polymerase	Escherichia coli	112-126
19120476-3	2009	RNA containing a triphosphate at the 5"-end was shown to activate RIG-I, but the exact structure of RNA supporting 5"-triphosphate recognition, the requirement of a 5"-triphosphate group, as well as the existence of RNA structures detected by RIG-I in the absence of 5"-triphosphate remain controversial.	triphosphoric acid	17-29	DExD/H-box helicase 58	Homo sapiens	66-71
17881202-2	2008	Insulin-loaded PEG-g-chitosan nanoparticles were prepared by the ionotropic gelation of PEG-g-chitosan solution using tripolyphosphate ions as the crosslinking agent.	triphosphoric acid	118-134	insulin	Oryctolagus cuniculus	0-7
19127140-2	2008	Synthesized through nitric oxide, carbon monoxide, and/or natriuretic peptide-mediated guanylate cyclase stimulation and guanosine triphosphate dephosphorylation, cyclic GMP is capable of stimulating a cascade of serine/threonine kinase events, including signaling through cyclic GMP- and/or cyclic AMP-dependent protein kinases, eliciting protein kinase-independent actions such as modulation of ion channels or transporters, or undergoing hydrolytic degradation through actions of cyclic GMP-regulated phosphodiesterases.	triphosphoric acid	131-143	5'-nucleotidase, cytosolic II	Homo sapiens	170-173
18164928-8	2008	However, it can be stated that the electrostatical interaction forces between the tested molecules insulin, benzoic acid, and tripolyphosphate and chitosan are found to be very weak.	triphosphoric acid	126-142	insulin	Homo sapiens	99-106
18067241-4	2008	Steady-state kinetics analysis of the incorporation of these triphosphate analogues by a poliovirus RdRp, 3D (pol), revealed that while the incorporation efficiency of 9a was comparable to RTP, 9b and 9c showed lower efficiency than RTP.	triphosphoric acid	61-73	MORN repeat containing 4	Homo sapiens	233-236
20641443-5	2004	This compound is converted into a triphosphate by cytosolic thymidine kinase (TK1), is not incorporated into the DNA strand, and terminates elongation of the DNA chain (7).	triphosphoric acid	34-46	thymidine kinase 1	Homo sapiens	78-81
17989916-1	2008	Deoxyribonucleoside triphosphate (dNTP) triphosphohydrolase (dNTPase) from Thermus thermophilus HB8 (TTHB8) hydrolyzes wide variety of dNTPs to deoxyribonucleoside and inorganic triphosphate in magnesium-dependent manner.	triphosphoric acid	168-190	NTPase	Drosophila melanogaster	61-68
18378536-2	2008	Gemcitabine is taken up into the cell via human nucleoside transporters (hNTs) and is intracellularly phosphorylated by deoxycytidine kinase (dCK) to its monophosphate and subsequently into its main active triphosphate metabolite 2",2"-difluorodeoxycytidine triphosphate (dFdCTP), which is incorporated into DNA and inhibits DNA synthesis.	triphosphoric acid	206-218	deoxycytidine kinase	Homo sapiens	120-140
18378536-2	2008	Gemcitabine is taken up into the cell via human nucleoside transporters (hNTs) and is intracellularly phosphorylated by deoxycytidine kinase (dCK) to its monophosphate and subsequently into its main active triphosphate metabolite 2",2"-difluorodeoxycytidine triphosphate (dFdCTP), which is incorporated into DNA and inhibits DNA synthesis.	triphosphoric acid	206-218	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	142-145
18243112-0	2008	The C-terminal regulatory domain is the RNA 5"-triphosphate sensor of RIG-I.	triphosphoric acid	47-59	DExD/H-box helicase 58	Homo sapiens	70-75
18690875-5	2008	In this regard, we proved that while AZT and its monophosphorylated derivative AZTMP were unable to chelate iron, the triphosphate form AZTTP displayed a significant capacity to remove iron from transferrin.	triphosphoric acid	118-130	transferrin	Homo sapiens	195-206
17654175-1	2007	PURPOSE: To evaluate the feasibility of exploiting ultrasonication coupled with ionotropic gelation in order to prepare tripolyphosphate (TPP)-chitosan glutamate nanoparticles suitable for the delivery of the enzyme prolidase.	triphosphoric acid	120-136	peptidase D	Homo sapiens	216-225
17654175-1	2007	PURPOSE: To evaluate the feasibility of exploiting ultrasonication coupled with ionotropic gelation in order to prepare tripolyphosphate (TPP)-chitosan glutamate nanoparticles suitable for the delivery of the enzyme prolidase.	triphosphoric acid	138-141	peptidase D	Homo sapiens	216-225
17009030-3	2007	Both CldAdo and FaraA induce apoptosis, as the triphosphates, via binding to Apaf-1.	triphosphoric acid	47-60	apoptotic peptidase activating factor 1	Homo sapiens	77-83
16863360-9	2006	The D atoms of CD(4) were displaced from the line between the C and O atoms, and were located near the face center of the polygon in the cage.	triphosphoric acid	122-129	CD4 molecule	Homo sapiens	15-20
17307033-5	2007	For RNA-sensing in the cytoplasm, RIG-I was recently shown to detect and directly bind to the 5"-end of certain viral RNA genomes, specifically, to a 5"-triphosphate group.	triphosphoric acid	153-165	DExD/H-box helicase 58	Homo sapiens	34-39
17297921-6	2007	The affinity of eIF5B for mant-GTPgammaS was about 2 times lower (Kd approximately 6.9 microM) and for mant-GMPPNP 1.5 times higher (Kd approximately 25.7 microM) than for mant-GTP, indicating that eIF5B tolerates modifications of the triphosphate moiety well.	triphosphoric acid	235-247	eukaryotic translation initiation factor 5B	Homo sapiens	16-21
17101674-6	2007	PSI-6130 monophosphate (PSI-6130-MP) was efficiently phosphorylated to the diphosphate and subsequently to the triphosphate by recombinant human UMP-CMP kinase and nucleoside diphosphate kinase, respectively.	triphosphoric acid	111-123	cytidine/uridine monophosphate kinase 2	Homo sapiens	145-159
17177551-2	2006	The addition of the type II, iron chelating antioxidants sodium tripolyphosphate (at pH 7.2) or milk mineral (at pH 5.6) negated the effect of added iron, slowing oxidation of myoglobin.	triphosphoric acid	57-80	myoglobin	Homo sapiens	176-185
16895920-1	2006	Escherichia coli nucleoside-diphosphate kinase (Ndk) catalyzes nucleoside triphosphate synthesis and maintains intracellular triphosphate pools.	triphosphoric acid	74-86	NME/NM23 nucleoside diphosphate kinase 4	Homo sapiens	48-51
16895920-2	2006	Mutants of E. coli lacking Ndk exhibit normal growth rates but show a mutator phenotype that cannot be entirely attributed to the absence of Ndk catalytic activity or to an imbalance in cellular triphosphates.	triphosphoric acid	195-208	NME/NM23 nucleoside diphosphate kinase 4	Homo sapiens	27-30
16766526-4	2006	Orf153 (ymfB) is a nonspecific nucleoside tri- and diphosphatase and atypically releases inorganic orthophosphate from triphosphates instead of pyrophosphate.	triphosphoric acid	119-132	hypothetical protein	Escherichia coli	0-6
17479429-1	2007	Novel triphosphate derivatives bearing bulky or small groups at alpha-position attached to the triphosphate residue through linkers of different structures and lengths were synthesized and studied as substrates toward terminal deoxynucleotidyltransferase.	triphosphoric acid	6-18	DNA nucleotidylexotransferase	Homo sapiens	218-254
17479429-1	2007	Novel triphosphate derivatives bearing bulky or small groups at alpha-position attached to the triphosphate residue through linkers of different structures and lengths were synthesized and studied as substrates toward terminal deoxynucleotidyltransferase.	triphosphoric acid	95-107	DNA nucleotidylexotransferase	Homo sapiens	218-254
17125260-6	2006	A beta,gamma-dichloromethylene modification in the triphosphate chain of 5-bromo-UTP was tolerated by all three receptor subtypes, thus opening up a new strategy to obtain ectonucleotide diphosphohydrolase- and phosphatase-resistant P2Y2, P2Y4, and P2Y6 receptor agonists.	triphosphoric acid	51-63	purinergic receptor P2Y2	Homo sapiens	233-237
17125260-6	2006	A beta,gamma-dichloromethylene modification in the triphosphate chain of 5-bromo-UTP was tolerated by all three receptor subtypes, thus opening up a new strategy to obtain ectonucleotide diphosphohydrolase- and phosphatase-resistant P2Y2, P2Y4, and P2Y6 receptor agonists.	triphosphoric acid	51-63	pyrimidinergic receptor P2Y4	Homo sapiens	239-243
17125260-6	2006	A beta,gamma-dichloromethylene modification in the triphosphate chain of 5-bromo-UTP was tolerated by all three receptor subtypes, thus opening up a new strategy to obtain ectonucleotide diphosphohydrolase- and phosphatase-resistant P2Y2, P2Y4, and P2Y6 receptor agonists.	triphosphoric acid	51-63	pyrimidinergic receptor P2Y6	Homo sapiens	249-262
16799820-1	2006	INTRODUCTION: Deoxycytidine kinase (DCK) is the rate-limiting enzyme of the intracellular phosphorylation of nucleoside anticancer drugs, including gemcitabine and beta-arabinofuranosylcytosine, to their active triphosphates.	triphosphoric acid	211-224	deoxycytidine kinase	Homo sapiens	14-34
16799820-1	2006	INTRODUCTION: Deoxycytidine kinase (DCK) is the rate-limiting enzyme of the intracellular phosphorylation of nucleoside anticancer drugs, including gemcitabine and beta-arabinofuranosylcytosine, to their active triphosphates.	triphosphoric acid	211-224	deoxycytidine kinase	Homo sapiens	36-39
16809816-4	2006	The Cet1 active site is unusually complex and located within a topologically closed hydrophilic beta-barrel (the triphosphate tunnel).	triphosphoric acid	113-125	polynucleotide 5'-phosphatase	Saccharomyces cerevisiae S288C	4-8
16180016-6	2006	Despite the fact that T-araC is a much poorer substrate, as compared to araC, for deoxycytidine kinase (the rate-limiting step in the formation of the triphosphates), similar intracellular concentrations of T-araC-5"-triphosphate (T-araCTP) and araCTP were formed in cells at these high, pharmacologically relevant concentrations due to similar Vmax"s.	triphosphoric acid	151-164	deoxycytidine kinase	Mus musculus	82-102
16751877-0	2006	Molecular dynamics DFT:B3LYP study of guanosinetriphosphate conversion into guanosinemonophosphate upon Mg2+ chelation of alpha and beta phosphate oxygens of the triphosphate tail.	triphosphoric acid	47-59	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	25-28
15968398-7	2005	We suggest that antithrombin might exert beneficial effects in disseminated intravascular coagulation by reducing platelet activation, observed as inhibited CD40 ligand expression, syndecan-4 shedding, and adenosine diphosphate- and adenosine triphosphate-release from activated platelets with subsequent inhibition of neutrophil respiratory burst.	triphosphoric acid	243-255	serpin family C member 1	Homo sapiens	16-28
17155910-3	2006	Synthesis by phage RNA polymerases from their natural promoters results in a 5 -terminal triphosphate that can trigger an interferon (IFN) response.	triphosphoric acid	89-101	interferon alpha 1	Homo sapiens	122-132
17155910-3	2006	Synthesis by phage RNA polymerases from their natural promoters results in a 5 -terminal triphosphate that can trigger an interferon (IFN) response.	triphosphoric acid	89-101	interferon alpha 1	Homo sapiens	134-137
16230416-2	2005	Gemcitabine is activated by dCyd kinase (dCK) and interferes, as its triphosphate dFdCTP, with tumor growth through incorporation into DNA.	triphosphoric acid	69-81	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	41-44
16084485-8	2005	The purine nucleoside diphosphates and triphosphates cause aconitase inactivation, but the monophosphates and CDP do not, consistent with the known nucleotide specificity of UCP3.	triphosphoric acid	39-52	uncoupling protein 3 (mitochondrial, proton carrier)	Mus musculus	174-178
15749695-6	2005	Triphosphate did induce aggregation of many of the IDE mutants.	triphosphoric acid	0-12	insulin degrading enzyme	Homo sapiens	51-54
15494400-0	2004	ATP effects on insulin-degrading enzyme are mediated primarily through its triphosphate moiety.	triphosphoric acid	75-87	insulin degrading enzyme	Homo sapiens	15-39
15855530-8	2005	When the cells were treated with L-FMAU or d4T, the amounts of the diphosphate and triphosphate metabolites of these analogs were increased, in accordance with an increase in human TMPK activity in cells.	triphosphoric acid	83-95	deoxythymidylate kinase	Homo sapiens	181-185
15771546-2	2005	In the present study, electrospray ionization is used to examine the behavior of anionic clusters of triphosphate with choline, acetylcholine, and betaine, and the behaviors of cationic clusters of triphosphate with the peptides bradykinin (RPPGFSPFR) and ARRPEGRTWAQPGY.	triphosphoric acid	198-210	kininogen 1	Homo sapiens	229-239
15533835-0	2005	Dual hydrolysis of diphosphate and triphosphate derivatives of oxidized deoxyadenosine by Orf17 (NtpA), a MutT-type enzyme.	triphosphoric acid	35-47	putative transposase	Escherichia coli	90-95
15533835-3	2005	Unexpectedly, the Orf17 protein degraded 8-hydroxy-2"-deoxyadenosine 5"-diphosphate 2.3-fold more efficiently than the corresponding triphosphate.	triphosphoric acid	133-145	putative transposase	Escherichia coli	18-23
15494400-11	2004	However, with small physiological peptides such as bradykinin and dynorphin B-9, ATP and triphosphate increased the rate of hydrolysis approximately 10-fold.	triphosphoric acid	89-101	kininogen 1	Homo sapiens	51-61
15145932-6	2004	In addition, DNA and RNA polymer-related compounds, such as nucleotide diphosphates and triphosphates, also inhibit the carbohydrate binding ability of SP-D, or approximately 60 kDa trimeric recombinant fragments of SP-D that are composed of the alpha-helical coiled-coil neck region and three CRDs (SP-D(n/CRD)) or SP-D(n/CRD) with eight GXY repeats (SPD(GXY)(8)(n/CRD)).	triphosphoric acid	88-101	surfactant associated protein D	Mus musculus	152-156
15548380-0	2004	Polymerization of the triphosphates of AraC, 2",2"-difluorodeoxycytidine (dFdC) and OSI-7836 (T-araC) by human DNA polymerase alpha and DNA primase.	triphosphoric acid	22-35	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	111-131
15548380-2	2004	We examined how the triphosphates of OSI-7836 (T-araCTP), cytarabine (araCTP), and gemcitabine (dFdCTP) affected the initiation of new DNA strands by the pol alpha primase complex.	triphosphoric acid	20-33	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	154-163
15145932-6	2004	In addition, DNA and RNA polymer-related compounds, such as nucleotide diphosphates and triphosphates, also inhibit the carbohydrate binding ability of SP-D, or approximately 60 kDa trimeric recombinant fragments of SP-D that are composed of the alpha-helical coiled-coil neck region and three CRDs (SP-D(n/CRD)) or SP-D(n/CRD) with eight GXY repeats (SPD(GXY)(8)(n/CRD)).	triphosphoric acid	88-101	surfactant associated protein D	Mus musculus	216-220
15145932-6	2004	In addition, DNA and RNA polymer-related compounds, such as nucleotide diphosphates and triphosphates, also inhibit the carbohydrate binding ability of SP-D, or approximately 60 kDa trimeric recombinant fragments of SP-D that are composed of the alpha-helical coiled-coil neck region and three CRDs (SP-D(n/CRD)) or SP-D(n/CRD) with eight GXY repeats (SPD(GXY)(8)(n/CRD)).	triphosphoric acid	88-101	surfactant associated protein D	Mus musculus	216-220
15145932-6	2004	In addition, DNA and RNA polymer-related compounds, such as nucleotide diphosphates and triphosphates, also inhibit the carbohydrate binding ability of SP-D, or approximately 60 kDa trimeric recombinant fragments of SP-D that are composed of the alpha-helical coiled-coil neck region and three CRDs (SP-D(n/CRD)) or SP-D(n/CRD) with eight GXY repeats (SPD(GXY)(8)(n/CRD)).	triphosphoric acid	88-101	surfactant associated protein D	Mus musculus	216-220
14967023-1	2004	S-Adenosylmethionine synthetase (MAT) catalyzes formation of S-adenosylmethionine (SAM) from ATP and l-methionine (Met) and hydrolysis of tripolyphosphate to PP(i) and P(i).	triphosphoric acid	138-154	methionine adenosyltransferase 1A	Rattus norvegicus	0-31
15105503-4	2004	Purified Hi95 (sestrin 2) protein supports adenosine triphosphate-dependent reduction of overoxidized PrxI in vitro, indicating that unlike AhpD, which is a disulfide reductase, sestrins are cysteine sulfinyl reductases.	triphosphoric acid	53-65	sestrin 2	Homo sapiens	9-13
15105503-4	2004	Purified Hi95 (sestrin 2) protein supports adenosine triphosphate-dependent reduction of overoxidized PrxI in vitro, indicating that unlike AhpD, which is a disulfide reductase, sestrins are cysteine sulfinyl reductases.	triphosphoric acid	53-65	sestrin 2	Homo sapiens	15-24
15105503-4	2004	Purified Hi95 (sestrin 2) protein supports adenosine triphosphate-dependent reduction of overoxidized PrxI in vitro, indicating that unlike AhpD, which is a disulfide reductase, sestrins are cysteine sulfinyl reductases.	triphosphoric acid	53-65	peroxiredoxin 1	Homo sapiens	102-106
15011952-7	2004	We tested for the inhibitory activities of the triphosphates of 4"-thio-FAC and gemcitabine against DNA polymerase alpha, beta and gamma.	triphosphoric acid	47-60	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	100-120
15011952-8	2004	The triphosphates of 4"-thio-FAC (4"-thio-FACTP) exhibited the potent inhibitory action against DNA polymerase alpha, whereas it showed moderate inhibition against DNA polymerase beta and little inhibition against DNA polymerase gamma.	triphosphoric acid	4-17	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	96-116
15011952-8	2004	The triphosphates of 4"-thio-FAC (4"-thio-FACTP) exhibited the potent inhibitory action against DNA polymerase alpha, whereas it showed moderate inhibition against DNA polymerase beta and little inhibition against DNA polymerase gamma.	triphosphoric acid	4-17	DNA polymerase beta	Homo sapiens	164-183
12756253-1	2003	The bifunctional dCTP deaminase-dUTPase (DCD-DUT) from Methanocaldococcus jannaschii catalyzes the deamination of the cytosine moiety in dCTP and the hydrolysis of the triphosphate moiety forming dUMP, thereby preventing uracil from being incorporated into DNA.	triphosphoric acid	168-180	Deoxyuridine triphosphatase	Drosophila melanogaster	32-39
14505676-0	2003	Adenosine-anchored triphosphate subsite probing: distinguishing between HER-2 and HER-4 tyrosine protein kinases.	triphosphoric acid	19-31	erb-b2 receptor tyrosine kinase 2	Homo sapiens	72-77
14505676-0	2003	Adenosine-anchored triphosphate subsite probing: distinguishing between HER-2 and HER-4 tyrosine protein kinases.	triphosphoric acid	19-31	erb-b2 receptor tyrosine kinase 4	Homo sapiens	82-87
14505676-1	2003	A strategy of full-site occupancy and stereospecific recognition in the triphosphate subsite was used to specifically inhibit two protein kinases HER-2 and HER-4 from the EGFR family.	triphosphoric acid	72-84	erb-b2 receptor tyrosine kinase 2	Homo sapiens	146-151
14505676-1	2003	A strategy of full-site occupancy and stereospecific recognition in the triphosphate subsite was used to specifically inhibit two protein kinases HER-2 and HER-4 from the EGFR family.	triphosphoric acid	72-84	erb-b2 receptor tyrosine kinase 4	Homo sapiens	156-161
14505676-2	2003	The SAR profiles of a panel of adenosine-anchored bicyclic heterocycles against HER-2 and HER-4 indicated that specificity can be derived for highly homologous protein kinases from stereospecific recognition in the triphosphate-subsite.	triphosphoric acid	215-227	sarcosine dehydrogenase	Homo sapiens	4-7
14505676-2	2003	The SAR profiles of a panel of adenosine-anchored bicyclic heterocycles against HER-2 and HER-4 indicated that specificity can be derived for highly homologous protein kinases from stereospecific recognition in the triphosphate-subsite.	triphosphoric acid	215-227	erb-b2 receptor tyrosine kinase 2	Homo sapiens	80-85
14505676-2	2003	The SAR profiles of a panel of adenosine-anchored bicyclic heterocycles against HER-2 and HER-4 indicated that specificity can be derived for highly homologous protein kinases from stereospecific recognition in the triphosphate-subsite.	triphosphoric acid	215-227	erb-b2 receptor tyrosine kinase 4	Homo sapiens	90-95
12799644-1	2003	Gemcitabine (2",2"-difluorodeoxycytidine) is a deoxycytidine analogue that is activated by deoxycytidine kinase (dCK) to its monophosphate and subsequently to its triphosphate dFdCTP, which is incorporated into both RNA and DNA, leading to DNA damage.	triphosphoric acid	163-175	deoxycytidine kinase	Homo sapiens	91-111
12799644-1	2003	Gemcitabine (2",2"-difluorodeoxycytidine) is a deoxycytidine analogue that is activated by deoxycytidine kinase (dCK) to its monophosphate and subsequently to its triphosphate dFdCTP, which is incorporated into both RNA and DNA, leading to DNA damage.	triphosphoric acid	163-175	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	113-116
12644689-3	2003	Both the native 4CL2 isoform from Arabidopsis (At4CL2 wild type) and the At4CL2 gain of function mutant M293P/K320L, which exhibits the capacity to use a broader range of phenolic substrates, catalyzed the synthesis of adenosine 5"-tetraphosphate (p(4)A) and adenosine 5"-pentaphosphate when incubated with MgATP(-2) and tripolyphosphate or tetrapolyphosphate (P(4)), respectively.	triphosphoric acid	321-337	4-coumarate:CoA ligase 2	Arabidopsis thaliana	47-53
12782329-2	2003	In addition to a magnesium ion, which is essential for catalysis, a potassium ion bound adjacent to the triphosphate moiety of ATP in a rat mitochondrial protein kinase, BCK (branched-chain alpha-ketoacid dehydrogenase kinase), has been shown to be indispensable for nucleotide binding and hydrolysis.	triphosphoric acid	104-116	creatine kinase B	Rattus norvegicus	170-173
12782329-2	2003	In addition to a magnesium ion, which is essential for catalysis, a potassium ion bound adjacent to the triphosphate moiety of ATP in a rat mitochondrial protein kinase, BCK (branched-chain alpha-ketoacid dehydrogenase kinase), has been shown to be indispensable for nucleotide binding and hydrolysis.	triphosphoric acid	104-116	creatine kinase B	Rattus norvegicus	175-225
12644689-3	2003	Both the native 4CL2 isoform from Arabidopsis (At4CL2 wild type) and the At4CL2 gain of function mutant M293P/K320L, which exhibits the capacity to use a broader range of phenolic substrates, catalyzed the synthesis of adenosine 5"-tetraphosphate (p(4)A) and adenosine 5"-pentaphosphate when incubated with MgATP(-2) and tripolyphosphate or tetrapolyphosphate (P(4)), respectively.	triphosphoric acid	321-337	4-coumarate:CoA ligase 2	Arabidopsis thaliana	73-79
11955062-3	2002	Mutagenesis revealed that part of the bias to initiate with GTP is due to an interaction between histidine 784 and the 2-amino group of a guanosine bound in the initiating triphosphate position.	triphosphoric acid	172-184	mitochondrial ribosome associated GTPase 1	Homo sapiens	60-63
12747574-6	2003	Relative molecular similarity to the substrate triphosphate chain is discussed in terms of the established inhibitory properties of carcinogens/tumour promoters on ATPase function, the carcinogen/ tumour promoting properties of ATPase inhibitors and the prediction of carcinogenic activity from chemical structure.	triphosphoric acid	47-59	dynein axonemal heavy chain 8	Homo sapiens	164-170
12747574-6	2003	Relative molecular similarity to the substrate triphosphate chain is discussed in terms of the established inhibitory properties of carcinogens/tumour promoters on ATPase function, the carcinogen/ tumour promoting properties of ATPase inhibitors and the prediction of carcinogenic activity from chemical structure.	triphosphoric acid	47-59	dynein axonemal heavy chain 8	Homo sapiens	228-234
12119016-7	2002	X-ray crystallography revealed that 3-NPN is structurally similar to ribavirin, and both compounds are substrates for adenosine kinase, an enzyme critical for conversion to the corresponding triphosphate in cells.	triphosphoric acid	191-203	adenosine kinase	Homo sapiens	118-134
11985476-7	2002	An (N)-methanocarba-2-methylthio-ADP analogue displayed an EC(50) at the hP2Y(1) receptor of 0.40 nM and was 55-fold more potent than the corresponding triphosphate and 16-fold more potent than the riboside 5"-diphosphate.	triphosphoric acid	152-164	purinergic receptor P2Y1	Homo sapiens	73-89
11985476-12	2002	The rates of hydrolysis of the corresponding triphosphates by recombinant rat NTPDase1 and 2 were studied.	triphosphoric acid	45-58	ectonucleoside triphosphate diphosphohydrolase 1	Rattus norvegicus	78-92
11903050-9	2002	The effects of these three mutations on ATP regulation indicated that this nucleotide inhibits human GDH through binding of its triphosphate tail to the GTP site and, at higher concentrations, activates the enzyme through binding of the nucleotide to the ADP site.	triphosphoric acid	128-140	glutamate dehydrogenase 1	Homo sapiens	101-104
11923581-1	2002	BACKGROUND: Thymidine kinase (TK) and thymidylate kinase (TMPK) are the two rate-limiting enzymes in the cascade of activation of the anti-human immunodeficiency virus (HIV) drug 3"-azido-3"-deoxythymidine (AZT) to its active triphosphate form.	triphosphoric acid	226-238	deoxythymidylate kinase	Homo sapiens	58-62
11754592-15	2002	The triphosphate was more potent than UTP in inducing a dilatory P2Y4 response (pEC(50) = 6.1 +/- 0.2), while the diphosphate was inactive as either an agonist or antagonist in a P2Y6 receptor-mediated contractile response.	triphosphoric acid	4-16	pyrimidinergic receptor P2Y4	Homo sapiens	65-69
11554538-2	2001	We report the synthesis of the triphosphate of 5-methyl 4-N-[6-(p-bromobenzamido)hex-1-yl]-2"-O-deoxycytidine 3A.	triphosphoric acid	31-43	exonuclease 1	Homo sapiens	81-86
11395522-1	2001	Cet1, the RNA triphosphatase component of the yeast mRNA capping apparatus, catalyzes metal-dependent gamma-phosphate hydrolysis within the hydrophilic interior of an eight-strand beta barrel (the "triphosphate tunnel"), which rests upon a globular protein core (the "pedestal").	triphosphoric acid	198-210	polynucleotide 5'-phosphatase	Saccharomyces cerevisiae S288C	0-4
11748109-1	2001	BACKGROUND: Nucleoside triphosphate diphosphohydrolase-1 (NTPDase1)/CD39 is the major ectonucleotidase of endothelial cells and monocytes and catalyzes phosphohydrolysis of extracellular nucleoside diphosphates (NDP) and triphosphates (NTP, eg, ATP and UTP).	triphosphoric acid	221-234	ectonucleoside triphosphate diphosphohydrolase 1	Mus musculus	12-56
11748109-1	2001	BACKGROUND: Nucleoside triphosphate diphosphohydrolase-1 (NTPDase1)/CD39 is the major ectonucleotidase of endothelial cells and monocytes and catalyzes phosphohydrolysis of extracellular nucleoside diphosphates (NDP) and triphosphates (NTP, eg, ATP and UTP).	triphosphoric acid	221-234	ectonucleoside triphosphate diphosphohydrolase 1	Mus musculus	58-66
11748109-1	2001	BACKGROUND: Nucleoside triphosphate diphosphohydrolase-1 (NTPDase1)/CD39 is the major ectonucleotidase of endothelial cells and monocytes and catalyzes phosphohydrolysis of extracellular nucleoside diphosphates (NDP) and triphosphates (NTP, eg, ATP and UTP).	triphosphoric acid	221-234	ectonucleoside triphosphate diphosphohydrolase 1	Mus musculus	68-72
11123928-1	2000	The specific catalytic roles of two groups of DNA polymerase beta active site residues identified from crystal structures were investigated: residues possibly involved in DNA template positioning (Lys280, Asn294, and Glu295) and residues possibly involved in binding the triphosphate moiety of the incoming dNTP (Arg149, Ser180, Arg183, and Ser188).	triphosphoric acid	271-283	DNA polymerase beta	Homo sapiens	46-65
11279161-1	2001	Cet1, the RNA triphosphatase component of the yeast mRNA capping apparatus, catalyzes metal-dependent gamma phosphate hydrolysis within the hydrophilic interior of a topologically closed 8-strand beta barrel (the "triphosphate tunnel").	triphosphoric acid	214-226	polynucleotide 5'-phosphatase	Saccharomyces cerevisiae S288C	0-4
11139608-3	2001	Pct1p hydrolyzes the gamma phosphate of triphosphate-terminated poly(A) in the presence of magnesium.	triphosphoric acid	40-52	choline-phosphate cytidylyltransferase	Saccharomyces cerevisiae S288C	0-5
11279098-2	2001	The active site of Cet1 resides within a topologically closed hydrophilic beta-barrel (the triphosphate tunnel) that is supported by a globular hydrophobic core.	triphosphoric acid	91-103	polynucleotide 5'-phosphatase	Saccharomyces cerevisiae S288C	19-23
11333366-7	2001	Cleaved caspase-9 first appeared in the cytosol at 2 hours and colocalized with cytochrome c. Terminal deoxynucleotidyl transferase-mediated uridine 5;-triphosphate-biotin nick and labeling (TUNEL) showed significant increase of positive cells in Sod2 -/+ mice compared with the wild-type in the cortex, but not in the caudate putamen.	triphosphoric acid	152-164	caspase 9	Mus musculus	8-17
11333366-7	2001	Cleaved caspase-9 first appeared in the cytosol at 2 hours and colocalized with cytochrome c. Terminal deoxynucleotidyl transferase-mediated uridine 5;-triphosphate-biotin nick and labeling (TUNEL) showed significant increase of positive cells in Sod2 -/+ mice compared with the wild-type in the cortex, but not in the caudate putamen.	triphosphoric acid	152-164	deoxynucleotidyltransferase, terminal	Mus musculus	94-131
11333366-7	2001	Cleaved caspase-9 first appeared in the cytosol at 2 hours and colocalized with cytochrome c. Terminal deoxynucleotidyl transferase-mediated uridine 5;-triphosphate-biotin nick and labeling (TUNEL) showed significant increase of positive cells in Sod2 -/+ mice compared with the wild-type in the cortex, but not in the caudate putamen.	triphosphoric acid	152-164	superoxide dismutase 2, mitochondrial	Mus musculus	247-251
11376566-3	2001	We observed potent inhibitory action of the triphosphate of 4"-thio-FAC (4"-thio-FACTP) against DNA polymerase alpha, whereas it showed moderate inhibition of DNA polymerase beta and little inhibition of DNA polymerase gamma.	triphosphoric acid	44-56	FA complementation group C	Homo sapiens	68-71
11376566-3	2001	We observed potent inhibitory action of the triphosphate of 4"-thio-FAC (4"-thio-FACTP) against DNA polymerase alpha, whereas it showed moderate inhibition of DNA polymerase beta and little inhibition of DNA polymerase gamma.	triphosphoric acid	44-56	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	96-116
11123928-8	2000	Of the four potential triphosphate-binding residues, Ser180 and Arg183 contribute significantly to k(pol) while the effects of R149A are relatively small and are primarily on K(d), and Ser188 appears to play a minimal role in the catalysis by Pol beta.	triphosphoric acid	22-34	DNA polymerase beta	Homo sapiens	243-251
10952986-2	2000	Here we report that Nm23 proteins can phosphorylate geranyl and farnesyl pyrophosphates to give triphosphates.	triphosphoric acid	96-109	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	20-24
10773428-6	2000	This agonistic effect was abolished in the presence of the triphosphate regeneration system (CP/CPK).	triphosphoric acid	59-71	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Homo sapiens	96-99
10970849-0	2000	Triphosphate structure of guanylate-binding protein 1 and implications for nucleotide binding and GTPase mechanism.	triphosphoric acid	0-12	guanylate binding protein 1	Homo sapiens	26-53
10938385-3	2000	hMTH1 protein reduces spontaneous mutations by removing 8-oxo-dGTP from the triphosphate pool.	triphosphoric acid	76-88	nudix hydrolase 1	Homo sapiens	0-5
10589681-2	1999	The 2.05 A crystal structure of yeast RNA triphosphatase Cet1p reveals a novel active site fold whereby an eight-stranded beta barrel forms a topologically closed triphosphate tunnel.	triphosphoric acid	163-175	polynucleotide 5'-phosphatase	Saccharomyces cerevisiae S288C	57-62
10718337-6	2000	2-Methylthio adenosine 5"-diphosphate and -triphosphate (2-MeSATP and 2-MeSADP) were the most potent agonists at the heterologously expressed receptors, with EC50 values of 50 to 70 nM for rP2Y1-eGFP and 0.06 to 0.4 nM for rP2Y1-wt.	triphosphoric acid	42-55	purinergic receptor P2Y1	Rattus norvegicus	189-194
10718337-6	2000	2-Methylthio adenosine 5"-diphosphate and -triphosphate (2-MeSATP and 2-MeSADP) were the most potent agonists at the heterologously expressed receptors, with EC50 values of 50 to 70 nM for rP2Y1-eGFP and 0.06 to 0.4 nM for rP2Y1-wt.	triphosphoric acid	42-55	purinergic receptor P2Y1	Rattus norvegicus	223-228
10718337-0	2000	A chimeric rat brain P2Y1 receptor tagged with green-fluorescent protein: high-affinity ligand recognition of adenosine diphosphates and triphosphates and selectivity identical to that of the wild-type receptor.	triphosphoric acid	137-150	purinergic receptor P2Y1	Rattus norvegicus	21-25
10521714-0	1999	Hydrolysis of tripolyphosphate by purified exopolyphosphatase from Saccharomyces cerevisiae cytosol: kinetic model.	triphosphoric acid	14-30	exopolyphosphatase	Saccharomyces cerevisiae S288C	43-61
10554100-2	1999	METHODS: Insulin-loaded chitosan nanoparticles were prepared by ionotropic gelation of chitosan with tripolyphosphate anions.	triphosphoric acid	101-117	insulin	Oryctolagus cuniculus	9-16
10521714-1	1999	The kinetics of hydrolysis of tripolyphosphate by purified exopolyphosphatase from Saccharomyces cerevisiae cytosol has been studied in the presence of Mg2+.	triphosphoric acid	30-46	exopolyphosphatase	Saccharomyces cerevisiae S288C	59-77
10350256-6	1999	Adenosine triphosphate and hemoglobin, possible spasmogens present in hemolysate, caused much smaller and more rapid increases in c-fos expression than whole hemolysate.	triphosphoric acid	10-22	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	130-135
10464142-2	1999	Absence of the multidrug-resistance protein 2 (MRP2; symbol ABCC2), an adenosine triphosphate-dependent conjugate export pump, from the hepatocyte canalicular membrane is the molecular basis of this syndrome.	triphosphoric acid	81-93	ATP binding cassette subfamily C member 2	Homo sapiens	15-45
10464142-2	1999	Absence of the multidrug-resistance protein 2 (MRP2; symbol ABCC2), an adenosine triphosphate-dependent conjugate export pump, from the hepatocyte canalicular membrane is the molecular basis of this syndrome.	triphosphoric acid	81-93	ATP binding cassette subfamily C member 2	Homo sapiens	47-51
10464142-2	1999	Absence of the multidrug-resistance protein 2 (MRP2; symbol ABCC2), an adenosine triphosphate-dependent conjugate export pump, from the hepatocyte canalicular membrane is the molecular basis of this syndrome.	triphosphoric acid	81-93	ATP binding cassette subfamily C member 2	Homo sapiens	60-65
10444166-4	1999	5" nucleotidase activity was strongly increased and deoxycytidine kinase activity was moderately reduced in all of the resistant variants, resulting in reduced accumulation of triphosphate analogues.	triphosphoric acid	176-188	deoxycytidine kinase	Homo sapiens	52-72
10432702-2	1999	C-5 is an attractive position since a flexible chain may permit the triphosphates to be generated.	triphosphoric acid	68-81	complement C5	Homo sapiens	0-3
9315840-9	1997	The loss of affinity of RanBP1 for the triphosphate form of RanDeltaC was a result of both a decrease of the association rate and a moderately increased dissociation of the RanDeltaC.RanBP1 complex.	triphosphoric acid	39-51	RAN binding protein 1	Homo sapiens	24-30
9852075-1	1998	Saccharomyces cerevisiae Cet1p catalyzes the first step of mRNA capping, the hydrolysis of the gamma phosphate of triphosphate-terminated RNA to form a 5" diphosphate end.	triphosphoric acid	114-126	polynucleotide 5'-phosphatase	Saccharomyces cerevisiae S288C	25-30
9710603-3	1998	Purified recombinant Cet1 catalyzes hydrolysis of the gamma phosphate of triphosphate-terminated RNA at a rate of 1 s-1.	triphosphoric acid	73-85	polynucleotide 5'-phosphatase	Saccharomyces cerevisiae S288C	21-25
9554879-13	1998	According to our model TM6 and TM7 are close to the adenine ring, TM3 and TM6 are close to the ribose moiety, and TM3, TM6, and TM7 are near the triphosphate chain.	triphosphoric acid	145-157	tropomyosin 3	Homo sapiens	66-69
9554879-13	1998	According to our model TM6 and TM7 are close to the adenine ring, TM3 and TM6 are close to the ribose moiety, and TM3, TM6, and TM7 are near the triphosphate chain.	triphosphoric acid	145-157	tropomyosin 3	Homo sapiens	114-117
9338077-3	1998	First, the activity of ara-C depends on conversion to its lethal triphosphate derivative, ara-CTP, a process that is influenced by multiple factors, including nucleoside transport, phosphorylation, deamination, and levels of competing metabolites, particularly dCTP.	triphosphoric acid	65-77	solute carrier family 25 member 1	Homo sapiens	94-97
10090736-7	1999	In meta-binding site I, the side chain of Glu209 (EL2) is within hydrogen-bonding distance (2.8 A) of the ribose O3", and Arg287 (EL3) coordinates both alpha- and beta-phosphates of the triphosphate chain, consistent with the insensitivity in potency of the 5"-monophosphate agonist, HT-AMP, to mutation of Arg287 to Lys.	triphosphoric acid	186-198	spectrin alpha, erythrocytic 1	Homo sapiens	50-53
10090736-7	1999	In meta-binding site I, the side chain of Glu209 (EL2) is within hydrogen-bonding distance (2.8 A) of the ribose O3", and Arg287 (EL3) coordinates both alpha- and beta-phosphates of the triphosphate chain, consistent with the insensitivity in potency of the 5"-monophosphate agonist, HT-AMP, to mutation of Arg287 to Lys.	triphosphoric acid	186-198	spectrin beta, erythrocytic	Homo sapiens	130-133
9933028-2	1999	Both drugs are phosphorylated by deoxycytidine kinase (dCK); the triphosphates, dFdCTP and ara-CTP, respectively, are incorporated into DNA.	triphosphoric acid	65-78	deoxycytidine kinase	Mus musculus	33-53
9933028-2	1999	Both drugs are phosphorylated by deoxycytidine kinase (dCK); the triphosphates, dFdCTP and ara-CTP, respectively, are incorporated into DNA.	triphosphoric acid	65-78	sticky	Drosophila melanogaster	55-58
9893994-11	1999	The affinity of wild-type RhoGAP for the triphosphate form of Rho is similar to that for Rho.GDP with aluminum fluoride.	triphosphoric acid	41-53	Rho GTPase activating protein 1	Homo sapiens	26-32
9861054-0	1998	Inositol 1,4,5-trisphosphate [correction of tris-phosphate] activation of inositol trisphosphate [correction of tris-phosphate] receptor Ca2+ channel by ligand tuning of Ca2+ inhibition.	triphosphoric acid	44-58	carbonic anhydrase 2 L homeolog	Xenopus laevis	137-140
9861054-0	1998	Inositol 1,4,5-trisphosphate [correction of tris-phosphate] activation of inositol trisphosphate [correction of tris-phosphate] receptor Ca2+ channel by ligand tuning of Ca2+ inhibition.	triphosphoric acid	44-58	carbonic anhydrase 2 L homeolog	Xenopus laevis	170-173
9345280-6	1997	The purified recombinant CET1 gene product, Cet1, exhibited an RNA 5"-triphosphatase activity which specifically removed the gamma-phosphate from the triphosphate-terminated RNA substrate, but not from nucleoside triphosphates, confirming the identity of the gene.	triphosphoric acid	150-162	polynucleotide 5'-phosphatase	Saccharomyces cerevisiae S288C	25-29
9345280-6	1997	The purified recombinant CET1 gene product, Cet1, exhibited an RNA 5"-triphosphatase activity which specifically removed the gamma-phosphate from the triphosphate-terminated RNA substrate, but not from nucleoside triphosphates, confirming the identity of the gene.	triphosphoric acid	150-162	polynucleotide 5'-phosphatase	Saccharomyces cerevisiae S288C	44-48
9315840-9	1997	The loss of affinity of RanBP1 for the triphosphate form of RanDeltaC was a result of both a decrease of the association rate and a moderately increased dissociation of the RanDeltaC.RanBP1 complex.	triphosphoric acid	39-51	RAN binding protein 1	Homo sapiens	183-189
10388042-2	1997	Gemcitabine needs to be activated by deoxycytidine kinase and other kinases to its triphosphate, gemcitabine triphosphate, which can be incorporated into RNA and DNA.	triphosphoric acid	83-95	deoxycytidine kinase	Homo sapiens	37-57
8756686-11	1996	The interaction of p21ras-triphosphate complexes with the Ras-binding domain (RBD) of the effector protein c-Raf-1, Raf-RBD, and with the GTPase activating protein GAP was studied by 31P NMR spectroscopy.	triphosphoric acid	26-38	HRas proto-oncogene, GTPase	Homo sapiens	19-25
9131407-7	1996	The P2Y1 receptor is specific for adenine nucleotides and slightly more sensitive to disphosphates than triphosphates.	triphosphoric acid	104-117	purinergic receptor P2Y1	Homo sapiens	4-17
8841119-9	1996	Soaking experiments with nucleotides other than dATP (namely, dCTP, dGTP, dTTP, ATP, ddATP, ddCTP, AZT-TP, and dATP alpha S) reveal a non-base-specific binding site on pol beta for the triphosphate and sugar moieties of a nucleotide, suggesting a possible mechanism for nucleotide selectivity whereby triphosphate-sugar binding precedes a check for correct base pairing with the template.	triphosphoric acid	185-197	DNA polymerase beta	Homo sapiens	168-176
8841119-9	1996	Soaking experiments with nucleotides other than dATP (namely, dCTP, dGTP, dTTP, ATP, ddATP, ddCTP, AZT-TP, and dATP alpha S) reveal a non-base-specific binding site on pol beta for the triphosphate and sugar moieties of a nucleotide, suggesting a possible mechanism for nucleotide selectivity whereby triphosphate-sugar binding precedes a check for correct base pairing with the template.	triphosphoric acid	301-313	DNA polymerase beta	Homo sapiens	168-176
8756686-11	1996	The interaction of p21ras-triphosphate complexes with the Ras-binding domain (RBD) of the effector protein c-Raf-1, Raf-RBD, and with the GTPase activating protein GAP was studied by 31P NMR spectroscopy.	triphosphoric acid	26-38	TNF receptor associated factor 3	Homo sapiens	107-114
8756686-11	1996	The interaction of p21ras-triphosphate complexes with the Ras-binding domain (RBD) of the effector protein c-Raf-1, Raf-RBD, and with the GTPase activating protein GAP was studied by 31P NMR spectroscopy.	triphosphoric acid	26-38	zinc fingers and homeoboxes 2	Homo sapiens	109-112
9415193-3	1996	Triphosphate derivative of 2CdA is commonly considered to be the agent inducing cell apoptosis resulting from inhibition of ribonucleotide reductase, DNA polymerases and DNA repair.	triphosphoric acid	0-12	cytidine deaminase	Homo sapiens	28-31
8568899-3	1996	The newly synthesised triphosphate derivative of dP (dPTP) is an excellent substrate for Taq polymerase (Km = 22 microM versus Km = 9.5 microM for TTP); it is incorporated in place of TTP and, with a approximately fourfold lower efficiency, in place of dCTP.	triphosphoric acid	22-34	Protein tyrosine phosphatase 69D	Drosophila melanogaster	53-57
8843338-2	1996	Tripolyphosphate, a model compound for polyanions, decreased the Km value of porcine cathepsin D for bovine serum albumin without affecting VMAX.	triphosphoric acid	0-16	cathepsin D	Homo sapiens	85-96
8843338-4	1996	Electrophoretic mobility of cathepsin D decreased as the tripolyphosphate concentration was increased, and the enzyme had no net charge at 50 mM triP.	triphosphoric acid	57-73	cathepsin D	Homo sapiens	28-39
8843338-6	1996	These results suggest that tripolyphosphate increased affinity of the enzyme for its substrate by cancelling positive charges on cathepsin D and thus decreasing the electrostatic repulsion.	triphosphoric acid	27-43	cathepsin D	Homo sapiens	129-140
7890612-8	1995	Rab5 N133I underwent no apparent proteolysis with 10 mM GTP or GDP, suggesting a "triphosphate" conformation may be induced in Rab5 N133I by either GTP or GDP.	triphosphoric acid	82-94	RAB5A, member RAS oncogene family	Homo sapiens	0-4
8770307-1	1996	BACKGROUND: P-glycoprotein (pgp), a 170-kDa adenosine triphosphate-dependent membrane drug efflux pump encoded by the mdr1 gene, mediates cross-resistance in tumor cells to structurally unrelated cancer drugs.	triphosphoric acid	54-66	ATP binding cassette subfamily B member 1	Homo sapiens	12-26
8770307-1	1996	BACKGROUND: P-glycoprotein (pgp), a 170-kDa adenosine triphosphate-dependent membrane drug efflux pump encoded by the mdr1 gene, mediates cross-resistance in tumor cells to structurally unrelated cancer drugs.	triphosphoric acid	54-66	ATP binding cassette subfamily B member 1	Homo sapiens	28-31
8770307-1	1996	BACKGROUND: P-glycoprotein (pgp), a 170-kDa adenosine triphosphate-dependent membrane drug efflux pump encoded by the mdr1 gene, mediates cross-resistance in tumor cells to structurally unrelated cancer drugs.	triphosphoric acid	54-66	ATP binding cassette subfamily B member 1	Homo sapiens	118-122
8547650-1	1996	The effectiveness of arabinosylcytosine (ara-C) for the treatment of acute myelogenous leukemia (AML) depends on the formation of its active metabolite, the triphosphate of ara-C (ara-CTP).	triphosphoric acid	157-169	solute carrier family 25 member 1	Homo sapiens	184-187
8547650-7	1996	To complement these studies, molecular actions of the triphosphate of ara-C and CdA on DNA extension by human DNA polymerase alpha in an in vitro model system was conducted.	triphosphoric acid	54-66	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	110-130
7540950-2	1995	Studies with a variety of cell lines demonstrated that Cl-F-ara-A is a potent cytotoxic agent; in cell-free systems, its triphosphate (Cl-F-ara-ATP) inhibited DNA polymerase alpha and ribonucleotide reductase.	triphosphoric acid	121-133	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	159-179
7890612-8	1995	Rab5 N133I underwent no apparent proteolysis with 10 mM GTP or GDP, suggesting a "triphosphate" conformation may be induced in Rab5 N133I by either GTP or GDP.	triphosphoric acid	82-94	RAB5A, member RAS oncogene family	Homo sapiens	127-131
7873530-2	1995	Each triphosphate preferentially inhibited pol delta, although ganciclovir triphosphate was the most impressive of the three; the Ki for inhibition of pol delta was 2 microM (competitive with dGTP), while the Kis for inhibition of pol alpha and epsilon were 80 and 140 microM, respectively.	triphosphoric acid	5-17	U2AF homology motif kinase 1	Homo sapiens	209-212
7873530-2	1995	Each triphosphate preferentially inhibited pol delta, although ganciclovir triphosphate was the most impressive of the three; the Ki for inhibition of pol delta was 2 microM (competitive with dGTP), while the Kis for inhibition of pol alpha and epsilon were 80 and 140 microM, respectively.	triphosphoric acid	5-17	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	231-240
7819218-6	1995	The pH dependence in the pKD/pH plots for the DANS nucleotides is basically similar to that for the unsubstituted nucleotides, i.e., for nucleoside diphosphates the slope delta pKD/delta pH < -1 at pH 5-6.5, = -1 at pH > 6.8, and only for triphosphates = -2 at pH > 7.2.	triphosphoric acid	245-258	protein kinase D1	Homo sapiens	25-28
7819218-6	1995	The pH dependence in the pKD/pH plots for the DANS nucleotides is basically similar to that for the unsubstituted nucleotides, i.e., for nucleoside diphosphates the slope delta pKD/delta pH < -1 at pH 5-6.5, = -1 at pH > 6.8, and only for triphosphates = -2 at pH > 7.2.	triphosphoric acid	245-258	protein kinase D1	Homo sapiens	177-180
7695256-1	1994	Inhibition constants were determined for 16 nucleoside analog triphosphates against human DNA polymerases alpha, beta, gamma, and epsilon, and 7 nucleoside analogs were examined as inhibitors of mitochondrial DNA synthesis in human Molt-4 cells in culture.	triphosphoric acid	62-75	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	90-144
8384554-3	1993	The glycine-rich phosphate anchor of the nucleotide binding fold motif of the protein kinase is a beta ribbon acting as a flap with conformational flexibility over the triphosphate group.	triphosphoric acid	168-180	amyloid beta precursor protein	Homo sapiens	96-102
8175692-7	1994	The PDR5 protein hydrolyzes nucleoside diphosphates and triphosphates.	triphosphoric acid	56-69	ATP-binding cassette multidrug transporter PDR5	Saccharomyces cerevisiae S288C	4-8
8174200-1	1994	Previous studies have demonstrated that treatment with fludarabine 4 h prior to arabinosylcytosine (ara-C) potentiates the accumulation of the active triphosphate of ara-C (ara-CTP) in leukemic lymphocytes.	triphosphoric acid	150-162	solute carrier family 25 member 1	Homo sapiens	177-180
8185716-1	1994	By the mediation of receptors in the endothelium, bradykinin, histamine, and thrombin--besides platelet-derived substances such as adenosine diphosphate and triphosphate (ADP, ATP) and serotonin--play an essential physiological role in the activation of the protective metabolic process in the endothelium, which is so important to vessel dilatation.	triphosphoric acid	157-169	kininogen 1	Homo sapiens	50-60
8185716-1	1994	By the mediation of receptors in the endothelium, bradykinin, histamine, and thrombin--besides platelet-derived substances such as adenosine diphosphate and triphosphate (ADP, ATP) and serotonin--play an essential physiological role in the activation of the protective metabolic process in the endothelium, which is so important to vessel dilatation.	triphosphoric acid	157-169	coagulation factor II, thrombin	Homo sapiens	77-85
8357792-1	1993	The three-dimensional structures and biochemical properties of two mutants of the G-domain (residues 1-166) of p21H-ras, p21 (G12D) and p21 (G12P), have been determined in the triphosphate-bound form using guanosine 5"-(beta,gamma-imido)triphosphate (GppNHp).	triphosphoric acid	176-188	H3 histone pseudogene 16	Homo sapiens	111-114
8357792-1	1993	The three-dimensional structures and biochemical properties of two mutants of the G-domain (residues 1-166) of p21H-ras, p21 (G12D) and p21 (G12P), have been determined in the triphosphate-bound form using guanosine 5"-(beta,gamma-imido)triphosphate (GppNHp).	triphosphoric acid	176-188	H3 histone pseudogene 16	Homo sapiens	121-124
8483469-0	1993	[Synthesis of nucleoside analogs containing a cis-2-pentene fragment and their triphosphates].	triphosphoric acid	79-92	suppressor of cytokine signaling 2	Homo sapiens	46-51
8299426-2	1993	The structure of the guanine nucleotide-binding domain of H-Ras (or p21H-ras) in the triphosphate conformation was determined at very high resolution (1.4 A).	triphosphoric acid	85-97	HRas proto-oncogene, GTPase	Homo sapiens	58-63
2061314-11	1991	In contrast to other NTPases (actin, hexokinase) tubulin appears able to catalyze the dissociation of the stable chromium-phosphate bonds, which implies a highly nucleophilic environment of the binding site of the metal-triphosphate moiety of GTP.	triphosphoric acid	220-232	hexokinase 1	Homo sapiens	37-47
1310978-6	1992	ATPase C1 hydrolyzed ATP only among the ribo- and deoxyribonucleoside triphosphates tested, and this fact distinguished ATPase C1 from ATPases B, C2, and C3, because the latter enzymes are capable of hydrolyzing both ATP and dATP.	triphosphoric acid	70-83	dynein, axonemal, heavy chain 8	Mus musculus	0-6
1310978-6	1992	ATPase C1 hydrolyzed ATP only among the ribo- and deoxyribonucleoside triphosphates tested, and this fact distinguished ATPase C1 from ATPases B, C2, and C3, because the latter enzymes are capable of hydrolyzing both ATP and dATP.	triphosphoric acid	70-83	dynein, axonemal, heavy chain 8	Mus musculus	120-126
1310978-6	1992	ATPase C1 hydrolyzed ATP only among the ribo- and deoxyribonucleoside triphosphates tested, and this fact distinguished ATPase C1 from ATPases B, C2, and C3, because the latter enzymes are capable of hydrolyzing both ATP and dATP.	triphosphoric acid	70-83	complement C3	Homo sapiens	146-156
1651238-4	1991	Here we report the location of the principal polyphosphate binding site on the surface of cytochrome c for both hexametaphosphate and a second polyphosphate, tripolyphosphate determined using 1H-NMR spectroscopy in conjunction with the relaxation probe potassium hexacyanochromium(III).	triphosphoric acid	158-174	cytochrome c, somatic	Homo sapiens	90-102
1651238-7	1991	Additionally the effect of sodium tripolyphosphate and sodium trimetaphosphate on cytochrome c aggregation is described.	triphosphoric acid	27-50	cytochrome c, somatic	Homo sapiens	82-94
1659321-1	1991	Nucleoside-diphosphate kinase is an enzyme which catalyzes the phosphorylation of nucleoside diphosphates into the corresponding triphosphates for nucleic acid biosynthesis.	triphosphoric acid	129-142	nucleoside diphosphate kinase	Saccharomyces cerevisiae S288C	0-29
1659321-6	1991	Substrate specificity studies show that the relative activity of nucleoside diphosphates (NDP) as phosphate acceptors is in the order of dTDP greater than CDP greater than UDP greater than dUDP greater than GDP greater than or equal to dGDP greater than dCDP greater than dADP greater than ADP; and the relative activity of triphosphate donors is in the order of UTP greater than dTTP greater than CTP greater than dCTP greater than dATP greater than ATP greater than or equal to dGTP greater than GTP.	triphosphoric acid	324-336	TAR DNA-binding protein-43 homolog	Drosophila melanogaster	137-141
34623203-5	2021	Successful interaction between CS, sodium tripolyphosphate (TPP) and lecithin was confirmed by Fourier-transform infrared spectroscopy, differential scanning calorimetry and X-ray diffraction.	triphosphoric acid	60-63	citrate synthase	Rattus norvegicus	31-33
1663346-2	1991	It is demonstrated that, besides GTP and pyrophosphate, also tripolyphosphate stimulates the assembly into microtubules at high concentrations (4.65 mM) of Mg2+.	triphosphoric acid	61-77	mucin 7, secreted	Homo sapiens	156-159
1663346-3	1991	The influence of Mg2+ is more pronounced in combination with pyrophosphate and tripolyphosphate than with GTP.	triphosphoric acid	79-95	mucin 7, secreted	Homo sapiens	17-20
2232707-1	1990	The recombinant human c-myc protein expressed in Escherichia coli can be efficiently labeled by ultraviolet-mediated cross-linking to dTTP and to a lesser extent to other nucleoside diphosphates and triphosphates, but not to nucleoside monophosphates.	triphosphoric acid	199-212	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	22-27
2232707-3	1990	Competition experiments also indicate that the affinity of c-myc protein for nucleoside diphosphates and triphosphates is approximately the same irrespective of the nature of the base, or of the pentose sugar, but the thymine base permits the most efficient photoactivated cross-linking.	triphosphoric acid	105-118	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	59-64
2196171-0	1990	Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis.	triphosphoric acid	33-45	HRas proto-oncogene, GTPase	Homo sapiens	62-67
2196171-0	1990	Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis.	triphosphoric acid	33-45	H3 histone pseudogene 16	Homo sapiens	68-71
1707752-14	1991	The three analogue triphosphates were incorporated into the DNA by DNA polymerase alpha as efficiently as dATP.	triphosphoric acid	19-32	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	67-87
1851005-2	1991	In this study we synthesized the triphosphate form of OXT-G, OXT-GTP, and examined its effect on the activities of HCMV DNA polymerase, herpes simplex type 2 (HSV-2) DNA polymerase and human DNA polymerase alpha.	triphosphoric acid	33-45	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	191-211
34747967-4	2021	The triphosphates were substrates for DNA polymerase in the enzymatic synthesis of modified DNA probes that showed only very weak fluorescence in aqueous buffer but a significant light-up and blue shift were observed when they interacted with proteins (histone H3.1 or p53 for double-stranded DNA probes or single-strand binding protein for single-stranded oligonucleotide probes).	triphosphoric acid	4-17	tumor protein p53	Homo sapiens	269-272
34648994-3	2021	METHODS: First, a nano-co-delivery of chitosan/tripolyphosphate (CS-TPP) was synthesized and characterized combining 5-aminolevulinic acid photodynamic therapy (ALA-PDT) with methylenetetrahydrofolate dehydrogenase 1-like (MTHFD1L) shRNA.	triphosphoric acid	47-63	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like	Homo sapiens	175-221
34648994-3	2021	METHODS: First, a nano-co-delivery of chitosan/tripolyphosphate (CS-TPP) was synthesized and characterized combining 5-aminolevulinic acid photodynamic therapy (ALA-PDT) with methylenetetrahydrofolate dehydrogenase 1-like (MTHFD1L) shRNA.	triphosphoric acid	47-63	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like	Homo sapiens	223-230
34789346-7	2021	The diet containing the highest STPP inclusion level and lowest Ca:P induced the highest peaks in post-prandial plasma P and PTH levels (1.8mmol/l and 27.2pg/ml, respectively) and the longest duration of concentrations raised above baseline were observed at 3 hours for P and 6 hours for PTH.	triphosphoric acid	32-36	parathyroid hormone	Felis catus	125-128
34273371-2	2021	The chitosan/Bacopa saponin/tripolyphosphate (CS/BS/TPP) nanoparticles conjugated with recombinant DNA vaccines were designed against Leptospirosis.	triphosphoric acid	28-44	filamin A	Homo sapiens	46-55
34668717-0	2021	Mechanism of Triphosphate Hydrolysis by Human MAT2A at 1.07 A Resolution.	triphosphoric acid	13-25	methionine adenosyltransferase 2A	Homo sapiens	46-51
34668717-4	2021	Hydrolysis of triphosphate to pyrophosphate and phosphate by MAT2A is required for product release and proceeds through a second chemical transition state.	triphosphoric acid	14-26	methionine adenosyltransferase 2A	Homo sapiens	61-66
34586444-1	2021	The adenosine triphosphate (ATP)-binding cassette efflux transporter G2 (ABCG2) was originally discovered in a multidrug-resistant breast cancer cell line.	triphosphoric acid	14-26	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	73-78
34179093-2	2021	The free energy of lysozyme interacting with two kinds of polyanionic excipients, citrate and tripolyphosphate, together with sodium chloride and TRIS-buffer, are analysed in multiple-walker metadynamics simulations to understand why tripolyphosphate causes lysozyme to precipitate but citrate does not.	triphosphoric acid	94-110	lysozyme	Homo sapiens	19-27
34564701-9	2021	Given this, Chitosan (CS)-tripolyphosphate (TPP)-siHAT1 nanoparticles were developed to block HAT1 expression and improve the antitumor effect of gemcitabine.	triphosphoric acid	26-42	histone acetyltransferase 1	Homo sapiens	94-98
34564701-9	2021	Given this, Chitosan (CS)-tripolyphosphate (TPP)-siHAT1 nanoparticles were developed to block HAT1 expression and improve the antitumor effect of gemcitabine.	triphosphoric acid	44-47	histone acetyltransferase 1	Homo sapiens	94-98
34119131-2	2021	CS-NPs (461.2-482.7 nm) were prepared by ionic gelation at pH 3.5 using tripolyphosphate (367.9 Da), dextran sulfate (>15 kDa), arabic gum (AG, >250 kDa), or hyaluronic acid (HA, >1000 kDa).	triphosphoric acid	72-88	citrate synthase	Homo sapiens	0-2
34360752-5	2021	By envisaging a biosafe cytocompatible and haemocompatible profile, this paper reports the systematic development of a delivery system based on CS and derived with HA and CDs to nanoencapsulate the model human phenylalanine hydroxylase (hPAH) through ionotropic gelation with tripolyphosphate (TPP), while maintaining protein stability and enzyme activity.	triphosphoric acid	276-292	phenylalanine hydroxylase	Homo sapiens	210-235
34360752-5	2021	By envisaging a biosafe cytocompatible and haemocompatible profile, this paper reports the systematic development of a delivery system based on CS and derived with HA and CDs to nanoencapsulate the model human phenylalanine hydroxylase (hPAH) through ionotropic gelation with tripolyphosphate (TPP), while maintaining protein stability and enzyme activity.	triphosphoric acid	276-292	phenylalanine hydroxylase	Homo sapiens	237-241
34360752-5	2021	By envisaging a biosafe cytocompatible and haemocompatible profile, this paper reports the systematic development of a delivery system based on CS and derived with HA and CDs to nanoencapsulate the model human phenylalanine hydroxylase (hPAH) through ionotropic gelation with tripolyphosphate (TPP), while maintaining protein stability and enzyme activity.	triphosphoric acid	294-297	phenylalanine hydroxylase	Homo sapiens	210-235
34360752-5	2021	By envisaging a biosafe cytocompatible and haemocompatible profile, this paper reports the systematic development of a delivery system based on CS and derived with HA and CDs to nanoencapsulate the model human phenylalanine hydroxylase (hPAH) through ionotropic gelation with tripolyphosphate (TPP), while maintaining protein stability and enzyme activity.	triphosphoric acid	294-297	phenylalanine hydroxylase	Homo sapiens	237-241
34179632-6	2021	The adsorption efficiency and reusability of the PEG/TPP-modified CS/AC membrane to remove RhB were investigated based on dynamic and static adsorption models.	triphosphoric acid	53-56	progestagen associated endometrial protein	Homo sapiens	49-52
34179632-7	2021	The results reveal that the adsorption performance of CS/AC membranes was significantly improved after the PEG/TPP modification based on the abundance macroporous structure.	triphosphoric acid	111-114	progestagen associated endometrial protein	Homo sapiens	107-110
34085825-6	2021	Although the mechanism for this remains incompletely resolved, NUC-1031-treated cells showed increased levels of triphosphate in both LSC and bulk tumor fractions.	triphosphoric acid	113-125	nucleobindin 1	Homo sapiens	63-66
34154515-0	2021	Molecular dynamic and in vitro evaluation of chitosan/tripolyphosphate nanoparticles as an insulin delivery system at two different pH values.	triphosphoric acid	54-70	insulin	Homo sapiens	91-98
34154515-2	2021	In the present study, insulin-loaded nanoparticles were prepared via ionic gelation of tripolyphosphate (TPP) and chitosan with 76 +- 5.5% encapsulation efficiency.	triphosphoric acid	87-103	insulin	Homo sapiens	22-29
34154515-2	2021	In the present study, insulin-loaded nanoparticles were prepared via ionic gelation of tripolyphosphate (TPP) and chitosan with 76 +- 5.5% encapsulation efficiency.	triphosphoric acid	105-108	insulin	Homo sapiens	22-29
34154515-8	2021	Also, RMSD plots for insulin and TPP molecules showed that insulin molecules diffused away from chitosan chains, and that TPP were randomly dispersed further away from the chitosan chain in an acidic medium than in a neutral one.	triphosphoric acid	33-36	insulin	Homo sapiens	59-66
34154515-8	2021	Also, RMSD plots for insulin and TPP molecules showed that insulin molecules diffused away from chitosan chains, and that TPP were randomly dispersed further away from the chitosan chain in an acidic medium than in a neutral one.	triphosphoric acid	122-125	insulin	Homo sapiens	21-28
34179093-2	2021	The free energy of lysozyme interacting with two kinds of polyanionic excipients, citrate and tripolyphosphate, together with sodium chloride and TRIS-buffer, are analysed in multiple-walker metadynamics simulations to understand why tripolyphosphate causes lysozyme to precipitate but citrate does not.	triphosphoric acid	94-110	lysozyme	Homo sapiens	258-266
34179093-2	2021	The free energy of lysozyme interacting with two kinds of polyanionic excipients, citrate and tripolyphosphate, together with sodium chloride and TRIS-buffer, are analysed in multiple-walker metadynamics simulations to understand why tripolyphosphate causes lysozyme to precipitate but citrate does not.	triphosphoric acid	234-250	lysozyme	Homo sapiens	19-27
34179093-2	2021	The free energy of lysozyme interacting with two kinds of polyanionic excipients, citrate and tripolyphosphate, together with sodium chloride and TRIS-buffer, are analysed in multiple-walker metadynamics simulations to understand why tripolyphosphate causes lysozyme to precipitate but citrate does not.	triphosphoric acid	234-250	lysozyme	Homo sapiens	258-266
34179093-3	2021	The resulting multiscale decomposition of energy and entropy components for water, sodium chloride, excipients and lysozyme reveals that lysozyme is more stabilised by the interaction of tripolyphosphate with basic residues.	triphosphoric acid	187-203	lysozyme	Homo sapiens	115-123
34179093-3	2021	The resulting multiscale decomposition of energy and entropy components for water, sodium chloride, excipients and lysozyme reveals that lysozyme is more stabilised by the interaction of tripolyphosphate with basic residues.	triphosphoric acid	187-203	lysozyme	Homo sapiens	137-145
2483878-2	1989	The triphosphates were competitive inhibitors of the viral enzyme with dTTP as the variable substrate and poly(rA)oligo(dT) as template, and preferentially inhibited the viral polymerase.	triphosphoric acid	4-17	ttp	Drosophila melanogaster	71-75
35465139-2	2022	Our study analyzes the binding mode of both natural triphosphate substrates as well as remdesivir triphosphate (the active form of drug), which is bound preferentially over ATP by RdRp while being poorly recognized by human RNA polymerase II (RNA Pol II).	triphosphoric acid	52-64	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	180-184
35623028-4	2022	MTZ at different concentrations (1, 2, 5, and 10 mg mL-1) was loaded into chitosan-sodium tripolyphosphate NPs.	triphosphoric acid	83-106	L1 cell adhesion molecule	Mus musculus	52-56
35464436-10	2022	We demonstrated that the active triphosphate form of remdesivir (RTP) and several reported non-nucleotide analog viral polymerase inhibitors blocked the RdRp in the in vitro RdRp activity assay and high-throughput screening model.	triphosphoric acid	32-44	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	153-157
35464436-10	2022	We demonstrated that the active triphosphate form of remdesivir (RTP) and several reported non-nucleotide analog viral polymerase inhibitors blocked the RdRp in the in vitro RdRp activity assay and high-throughput screening model.	triphosphoric acid	32-44	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	174-178
35110538-3	2022	Once in cells, AT-527 is converted into its triphosphate form, AT-9010, that presumably targets the viral RNA-dependent RNA polymerase (RdRp, nsp12), for incorporation into viral RNA.	triphosphoric acid	44-56	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	136-140
35158911-1	2022	SAMHD1 is a deoxynucleotide triphosphate (dNTP) triphosphohydrolase with important roles in the control of cell proliferation and apoptosis, either through the regulation of intracellular dNTPs levels or the modulation of the DNA damage response.	triphosphoric acid	28-40	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
3567973-2	1987	Studies were performed to determine if m-AMSA affected the pharmacokinetics of the active triphosphate ara-CTP in HL-60 and K562 cells in culture.	triphosphoric acid	90-102	solute carrier family 25 member 1	Homo sapiens	107-110
2684960-2	1989	The fluorescent nucleotide 2",3"-trinitrophenyl-ATP (TNP-ATP) binds at the triphosphate substrate binding site of the large (Klenow) fragment of DNA polymerase I (Pol I) as detected by direct binding studies measuring the increase in fluorescence of this ligand (n = 1.0, KD = 0.07 microM).	triphosphoric acid	75-87	DNA polymerase iota	Homo sapiens	149-161
2684960-2	1989	The fluorescent nucleotide 2",3"-trinitrophenyl-ATP (TNP-ATP) binds at the triphosphate substrate binding site of the large (Klenow) fragment of DNA polymerase I (Pol I) as detected by direct binding studies measuring the increase in fluorescence of this ligand (n = 1.0, KD = 0.07 microM).	triphosphoric acid	75-87	DNA polymerase iota	Homo sapiens	163-168
2476675-0	1989	Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation.	triphosphoric acid	93-105	H3 histone pseudogene 16	Homo sapiens	82-85
2713339-12	1989	In addition, peptide B27 was flanked by a sequence that has been implicated in triphosphate binding in other proteins.	triphosphoric acid	79-91	melanocortin 2 receptor accessory protein	Homo sapiens	21-24
2897846-0	1988	IF1 inhibition of mitochondrial F1-ATPase is correlated to entrapment of four adenine- or guanine-nucleotides including at least one triphosphate.	triphosphoric acid	133-145	ATP synthase inhibitory factor subunit 1	Homo sapiens	0-3
3335008-8	1988	The decreased rate of accumulation of products of dCK in intact cells containing 110 microM ara-CTP suggests that this active triphosphate may limit its own synthesis and phosphorylation of other substrates.	triphosphoric acid	126-138	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	50-53
3607288-6	1987	Incubation with 10(-3) mol/L of dCyd reduced the 4-hour intracellular accumulation of the triphosphate derivative of Ara-C (Ara-CTP) in both normal and leukemic cells by greater than 98%; under identical conditions, a significant expansion of the intracellular of the triphosphate derivative of dCyd (dCTP) pools was observed in normal bone marrow mononuclear cells but not in leukemic blasts.	triphosphoric acid	90-102	Cyd	Drosophila melanogaster	32-36
3607288-6	1987	Incubation with 10(-3) mol/L of dCyd reduced the 4-hour intracellular accumulation of the triphosphate derivative of Ara-C (Ara-CTP) in both normal and leukemic cells by greater than 98%; under identical conditions, a significant expansion of the intracellular of the triphosphate derivative of dCyd (dCTP) pools was observed in normal bone marrow mononuclear cells but not in leukemic blasts.	triphosphoric acid	268-280	Cyd	Drosophila melanogaster	32-36
3142104-4	1988	Chelation of the Cd2+ ion by STPP, EDTA or DTPA prior to oral administration reduced mortality, tissue damage and whole body retention of cadmium.	triphosphoric acid	29-33	CD2 antigen	Mus musculus	17-20
3114749-5	1987	The 5"-terminal triphosphate, present on the primary transcript, remains intact through 3"-terminal maturation and through subsequent transport of the tRNA to the cytoplasm.	triphosphoric acid	16-28	mitochondrially encoded tRNA glycine	Homo sapiens	151-155
3700397-0	1986	3-Deazaguanosine is metabolized to the triphosphate derivative in Chinese hamster cells deficient in hypoxanthine-guanine phosphoribosyltransferase.	triphosphoric acid	39-51	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	101-147
3753506-1	1986	The binding of p3A4,3"-32P [pCp] to rabbit reticulocyte RNase L can be displaced by the trimer and tetramer triphosphates of 2",5"-oligoadenylates (2-5A).	triphosphoric acid	108-121	LOW QUALITY PROTEIN: 2-5A-dependent ribonuclease	Oryctolagus cuniculus	56-63
3012321-0	1986	Inhibition of herpes simplex virus-induced DNA polymerases and cellular DNA polymerase alpha by triphosphates of acyclic guanosine analogs.	triphosphoric acid	96-109	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	72-92
3700397-8	1986	These observations indicate that 3-deazaguanosine can be metabolized, in Chinese hamster ovary cells, to the triphosphate derivative in lieu of the action of hypoxanthine-guanine phosphoribosyltransferase.	triphosphoric acid	109-121	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	158-204
2411264-2	1985	Based on studies using mRNA-dependent rabbit reticulocyte lysates and the degradation of [3H] polyadenylated mRNA, the greater inhibitory effects of trimer or tetramer triphosphates at the higher K+ is shown to be due to a more active 2-5A-dependent endoribonuclease (RNase L).	triphosphoric acid	168-181	LOW QUALITY PROTEIN: 2-5A-dependent ribonuclease	Oryctolagus cuniculus	268-275
3004981-1	1986	The ATP substrate site in the epidermal growth factor (EGF) receptor was mapped by using a series of 26 ATP derivatives with modifications at the base, ribose or triphosphate moiety.	triphosphoric acid	162-174	epidermal growth factor receptor	Homo sapiens	30-68
3902833-7	1985	When insulin and angiotensinogen were used as substrate, ATP, other nucleoside triphosphates, ADP, inorganic triphosphate, pyrophosphate, and phosphate were effective.	triphosphoric acid	99-121	insulin	Bos taurus	5-12
2983088-0	1985	Inhibition of cellular DNA polymerase alpha and human cytomegalovirus-induced DNA polymerase by the triphosphates of 9-(2-hydroxyethoxymethyl)guanine and 9-(1,3-dihydroxy-2-propoxymethyl)guanine.	triphosphoric acid	100-113	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	23-43
2983706-1	1985	An enzyme catalyzing the elimination of triphosphate from 7,8-dihydroneopterin triphosphate in the presence of Mg2+ has been purified approx.	triphosphoric acid	40-52	mucin 7, secreted	Homo sapiens	111-114
6734560-14	1984	The toxicity of parenterally administered Cd2+ is strongly enhanced when administered as complexes with NTA or STPP , but it is much decreased when administered as a complex with EDTA.	triphosphoric acid	111-115	CD2 molecule	Homo sapiens	42-45
6873060-1	1983	The binding of adenosine 5"-[beta, gamma-imido]triphosphate, pyrophosphate and triphosphate to the active site of myosin subfragment-1 was assessed in the presence and absence of Mg2+ by direct and indirect methods.	triphosphoric acid	47-59	myosin heavy chain 14	Homo sapiens	114-120