PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 6225713-10 1983 Moreover, PSP t/2 was well correlated with the maximal tubular secretion rate of p-amino-hippuric acid. p-Aminohippuric Acid 81-102 persephin Rattus norvegicus 10-13 6126158-0 1982 Modification of the acceptor binding site of gamma-glutamyl transpeptidase by the diazonium derivatives of p-aminohippurate and p-aminobenzoate. p-Aminohippuric Acid 107-123 inactive glutathione hydrolase 2 Homo sapiens 45-74 6194576-5 1983 In vitro incubation of renal cortical slices obtained from CBr4-treated animals revealed a significant depression of organic anion transport, i.e., decreased transport of p-aminohippurate (PAH). p-Aminohippuric Acid 171-187 carbonyl reductase 4 Rattus norvegicus 59-63 6194576-5 1983 In vitro incubation of renal cortical slices obtained from CBr4-treated animals revealed a significant depression of organic anion transport, i.e., decreased transport of p-aminohippurate (PAH). p-Aminohippuric Acid 189-192 carbonyl reductase 4 Rattus norvegicus 59-63 6293641-0 1982 Choline and PAH transport across blood-CSF barriers: the effect of lithium. p-Aminohippuric Acid 12-15 colony stimulating factor 2 Homo sapiens 39-42 6293641-1 1982 The components of the blood-CSF barrier responsible for the transport of p-aminohippuric acid (PAH) and choline from CSF to blood were identified using in vitro preparations of frog choroid plexus and arachnoid membranes. p-Aminohippuric Acid 73-93 colony stimulating factor 2 Homo sapiens 28-31 6293641-1 1982 The components of the blood-CSF barrier responsible for the transport of p-aminohippuric acid (PAH) and choline from CSF to blood were identified using in vitro preparations of frog choroid plexus and arachnoid membranes. p-Aminohippuric Acid 73-93 colony stimulating factor 2 Homo sapiens 117-120 6293641-1 1982 The components of the blood-CSF barrier responsible for the transport of p-aminohippuric acid (PAH) and choline from CSF to blood were identified using in vitro preparations of frog choroid plexus and arachnoid membranes. p-Aminohippuric Acid 95-98 colony stimulating factor 2 Homo sapiens 28-31 6293641-1 1982 The components of the blood-CSF barrier responsible for the transport of p-aminohippuric acid (PAH) and choline from CSF to blood were identified using in vitro preparations of frog choroid plexus and arachnoid membranes. p-Aminohippuric Acid 95-98 colony stimulating factor 2 Homo sapiens 117-120 7069622-9 1982 In the first hour of prolactin administration (in comparison with the control group), urine flow, sodium output and osmolal output were all significantly reduced (P less than 0.02); there was also a reduction (P less than 0.05) in renal plasma flow (p-amino-hippurate clearance), but the filtration fraction did not alter. p-Aminohippuric Acid 250-267 prolactin Rattus norvegicus 21-30 7284798-1 1981 In vitro uptake of an organic base (choline) and an organic acid (p-aminohippuric acid; PAH), both radiolabelled, was measured in isolated choroid plexus of rat and rabbit, and expressed as tissue/medium ratios. p-Aminohippuric Acid 66-86 phenylalanine hydroxylase Rattus norvegicus 88-91 7438334-5 1980 Despite a similar increase in PAH clearance after secretin (+ 2.21 ml/min; P < 0.01), UNaV remained unchanged and PPF was only slightly, although significantly, increased (from 50 +/- 2.6 ml/min 100 g to 65 +/- 2.75 ml/min 100 g; P < 0.05). p-Aminohippuric Acid 30-33 secretin Rattus norvegicus 50-58 7029782-2 1981 injections with 40 mg/kg of 1,2-dibromo-3-chloropropane (DBCP) reduced the in vitro accumulation of p-aminohippurate (PAH) and tetraethylammonium (TEA) by slices of renal cortex and increased blood urea nitrogen (BUN) concentration in both male and female rats, but elevated serum glutamic pyruvic transaminase (GPT) and glutamic oxaloacetic transaminase (GOT) activities in females only. p-Aminohippuric Acid 118-121 glutamic--pyruvic transaminase Rattus norvegicus 281-310 7029782-2 1981 injections with 40 mg/kg of 1,2-dibromo-3-chloropropane (DBCP) reduced the in vitro accumulation of p-aminohippurate (PAH) and tetraethylammonium (TEA) by slices of renal cortex and increased blood urea nitrogen (BUN) concentration in both male and female rats, but elevated serum glutamic pyruvic transaminase (GPT) and glutamic oxaloacetic transaminase (GOT) activities in females only. p-Aminohippuric Acid 118-121 glutamic--pyruvic transaminase Rattus norvegicus 312-315 7029782-3 1981 Four consecutive treatments with 1,2-dibromoethane (EDB) reduced the accumulation of PAH in male rats, but failed to alter TEA accumulation, BUN concentration or GPT and GOT activities in rats of either sex. p-Aminohippuric Acid 85-88 vesicle-associated membrane protein 8 Rattus norvegicus 52-55 7313301-1 1981 The effect produced by unconjugated bilirubin (UB) on p-aminohippuric acid (PAH) translocation from plasma to the urine, was analyzed by using an isolated rat kidney preparation applying the multiple indicator dilution technique. p-Aminohippuric Acid 54-74 phenylalanine hydroxylase Rattus norvegicus 76-79 7457604-1 1981 The contributions of the renal venous portal and the renal arterial circulations to the renal clearance of p-aminohippuric acid (PAH) and uric acid were determined in the unanesthetized chicken by the simultaneous use of the urinary clearance technique and the Sperber preparation. p-Aminohippuric Acid 107-127 phenylalanine hydroxylase Gallus gallus 129-132 7000463-2 1980 PAH clearance (CPAH) and glomerular filtration rate (GFR) were normal or increased in early hypertension and depressed at later stages, especially in malignant cases. p-Aminohippuric Acid 0-3 carboxypeptidase A6 Homo sapiens 15-19 7000463-3 1980 The PAH extraction ratio was depressed only in patients with low CPAH values. p-Aminohippuric Acid 4-7 carboxypeptidase A6 Homo sapiens 65-69 465171-6 1979 A transient fall in PAH and inulin clearances was observed with vasopressin in both malnourished groups with a mild drop in the normal group. p-Aminohippuric Acid 20-23 arginine vasopressin Homo sapiens 64-75 847388-1 1977 Renal extraction of gastrin in patients with normal clearance of inulin and p-aminohippuric acid was assessed by gastrin radioimmunoassay. p-Aminohippuric Acid 76-96 gastrin Homo sapiens 20-27 668809-3 1978 ml/min/100 g kidney weight and sodium excretion from 0.15 +/- 0.03 to 0.99 +/- 0.10 mmol/min/100 g. PAH and inulin clearance increased by 42 and 58%, respectively, while plasma renin activity and urinary excretion of PGF2 alpha-like immunoreactivity were reduced (P less than 0.05). p-Aminohippuric Acid 100-103 LOW QUALITY PROTEIN: renin Oryctolagus cuniculus 177-182 603306-2 1977 Bradykinin, when injected into the renal artery of the dog, reduced the proximal reabsorption of sodium and water and decreased the secretion of p-aminohippuric acid (PAH). p-Aminohippuric Acid 145-165 kininogen 1 Canis lupus familiaris 0-10 603306-2 1977 Bradykinin, when injected into the renal artery of the dog, reduced the proximal reabsorption of sodium and water and decreased the secretion of p-aminohippuric acid (PAH). p-Aminohippuric Acid 167-170 kininogen 1 Canis lupus familiaris 0-10 603306-4 1977 This enabled us to conclude that Bk decreased the transport efficiency of sodium and PAH. p-Aminohippuric Acid 85-88 kininogen 1 Canis lupus familiaris 33-35 603306-5 1977 The demonstration of the inhibitory effects of Bk on PAH secretion suggests that the inhibition of acid secretion is dependent not only upon the increase in medullary blood flow, but also upon a reduction of the cortical clearance of PAH. p-Aminohippuric Acid 53-56 kininogen 1 Canis lupus familiaris 47-49 603306-5 1977 The demonstration of the inhibitory effects of Bk on PAH secretion suggests that the inhibition of acid secretion is dependent not only upon the increase in medullary blood flow, but also upon a reduction of the cortical clearance of PAH. p-Aminohippuric Acid 234-237 kininogen 1 Canis lupus familiaris 47-49 835603-1 1977 In vitro concentrative transport to tritiated p-aminohippuric acid (3H-PAH) was evaluated in renal biopsy specimens from human subjects by section freeze-dry autoradiography. p-Aminohippuric Acid 46-66 phenylalanine hydroxylase Homo sapiens 71-74 556852-1 1977 Renal excretion of para-aminohippuric acid (PAH) was studied during PAH loading on unilaterally splanchnicotomized ("denervated") anaesthetized dogs. p-Aminohippuric Acid 19-42 phenylalanine hydroxylase Canis lupus familiaris 44-47 1271149-2 1976 Inulin and PAH clearances were markedly depressed in neonates with RDS as compared to controls (5.9 +/- 0.6 vs 9.3 +/- 0.8 ml/min/m2 (p less than 0.01) and 13.5 +/- 2.0 vs 23.2 +/- 1.2 ml/min/m2 ( p less than 0.01), respectively). p-Aminohippuric Acid 11-14 peripherin 2 Homo sapiens 67-70 1267539-5 1976 The excretion of furosemide by the kidney is competitively inhibited by p-aminohippuric acid (PAH). p-Aminohippuric Acid 72-92 phenylalanine hydroxylase Rattus norvegicus 94-97 1020568-1 1976 Repeated pretreatment with p-aminohippuric acid (PAH), probenecide, cyclopenthiazide, and phenobarbital stimulates the renal excretion of PAH. p-Aminohippuric Acid 27-47 phenylalanine hydroxylase Rattus norvegicus 49-52 1020568-1 1976 Repeated pretreatment with p-aminohippuric acid (PAH), probenecide, cyclopenthiazide, and phenobarbital stimulates the renal excretion of PAH. p-Aminohippuric Acid 27-47 phenylalanine hydroxylase Rattus norvegicus 138-141 13894152-0 1961 Relationship between renal succinoxidase activity and maximal transport rates of paminohippurate (Tm-PAH) in various representative vertebrates. p-Aminohippuric Acid 81-96 phenylalanine hydroxylase Homo sapiens 101-104 1147044-5 1975 Apparent luminal membrane permeability to PAH, calculated from perfusion studies, averaged about 3.5 x 10(-5) cm sec(-1) in 3 mM potassium, 1.15 x 10(-5) cm sec(-1) in 10 mM potassium, and 0.48 x 10(-5) cm sec(-1) in 40 mM potassium. p-Aminohippuric Acid 42-45 secretory blood group 1, pseudogene Homo sapiens 113-119 1147044-5 1975 Apparent luminal membrane permeability to PAH, calculated from perfusion studies, averaged about 3.5 x 10(-5) cm sec(-1) in 3 mM potassium, 1.15 x 10(-5) cm sec(-1) in 10 mM potassium, and 0.48 x 10(-5) cm sec(-1) in 40 mM potassium. p-Aminohippuric Acid 42-45 secretory blood group 1, pseudogene Homo sapiens 157-163 1147044-5 1975 Apparent luminal membrane permeability to PAH, calculated from perfusion studies, averaged about 3.5 x 10(-5) cm sec(-1) in 3 mM potassium, 1.15 x 10(-5) cm sec(-1) in 10 mM potassium, and 0.48 x 10(-5) cm sec(-1) in 40 mM potassium. p-Aminohippuric Acid 42-45 secretory blood group 1, pseudogene Homo sapiens 157-163 1245602-6 1976 P113 also reduced the clearance of para-aminohippurate, creatinine, sodium, and potassium, a pattern similar to that induced by A II. p-Aminohippuric Acid 35-54 signal transducer and activator of transcription 2 Homo sapiens 0-4 13891157-4 1962 Inulin and PAH clearance studies showed that oxytocin increased the daytime glomerular filtration rate. p-Aminohippuric Acid 11-14 oxytocin/neurophysin I prepropeptide Homo sapiens 45-53 33991922-0 2021 Mutagenicity risk prediction of PAH and derivative mixtures by in silico simulations oriented from CYP compound I-mediated metabolic activation. p-Aminohippuric Acid 32-35 peptidylprolyl isomerase G Homo sapiens 99-102 33705673-7 2021 EPO-treated rats showed an increase in PAH systemic clearance, in its elimination rate constant, and in urinary PAH levels, while PAH in renal tissue was decreased. p-Aminohippuric Acid 39-42 erythropoietin Rattus norvegicus 0-3 33684704-4 2021 Sharp increases in PAH concentrations were observed after 6-96 h in exposure media and oyster tissues, suggesting that these compounds were leached from the painted structures. p-Aminohippuric Acid 19-22 spen family transcriptional repressor Homo sapiens 0-5 33991922-3 2021 Cytochrome P450 enzymes (CYPs) play important roles in PAH-induced carcinogenicity via metabolic activation, and CYP conformations with compound I structures strongly influence metabolic sites and metabolite species. p-Aminohippuric Acid 55-58 peptidylprolyl isomerase G Homo sapiens 25-28 33522520-2 2021 A screening of natural compounds purified from marine sponges led to the identification of the first PTCH1 efflux inhibitor, panicein A hydroquinone (PAH), demonstrated to increase doxorubicin toxicity in vitro and vemurafenib toxicity in vitro and in vivo. p-Aminohippuric Acid 150-153 patched 1 Homo sapiens 101-106 33522520-7 2021 Our results suggest that the Neck pocket is the preferential binding site for PAH analogues on PTCH1, and that compounds assuming an open cylindric-like shape in solution are most likely to be good binders for PTCH1. p-Aminohippuric Acid 78-81 patched 1 Homo sapiens 95-100 33522520-7 2021 Our results suggest that the Neck pocket is the preferential binding site for PAH analogues on PTCH1, and that compounds assuming an open cylindric-like shape in solution are most likely to be good binders for PTCH1. p-Aminohippuric Acid 78-81 patched 1 Homo sapiens 210-215 33705673-7 2021 EPO-treated rats showed an increase in PAH systemic clearance, in its elimination rate constant, and in urinary PAH levels, while PAH in renal tissue was decreased. p-Aminohippuric Acid 112-115 erythropoietin Rattus norvegicus 0-3 33705673-7 2021 EPO-treated rats showed an increase in PAH systemic clearance, in its elimination rate constant, and in urinary PAH levels, while PAH in renal tissue was decreased. p-Aminohippuric Acid 112-115 erythropoietin Rattus norvegicus 0-3 33705673-9 2021 The EPO-induced increase in PAH clearance is accounted for by the increase in its renal secretion mediated by the organic anion transporters. p-Aminohippuric Acid 28-31 erythropoietin Rattus norvegicus 4-7 33356252-1 2021 Metalcyclopentadienyl complexes (MCp)+ (M = Fe, Ru, Os) bound to the large polyaromatic hydrogenated hydrocarbon (PAH) C96H24 used as a model for pristine graphene have been studied using a density functional theory (DFT) generalized gradient approximation (PBE functional) to reveal their structural features and dynamic behavior. p-Aminohippuric Acid 114-117 CD46 molecule Homo sapiens 33-36 33670955-5 2021 We showed that all three drugs significantly increased the accumulation of ubiquitinated OAT3, which was consistent with decreased intracellular 20S proteasomal activity; stimulated OAT3-mediated transport of estrone sulfate and p-aminohippuric acid; and increased OAT3 surface expression. p-Aminohippuric Acid 229-249 solute carrier family 22 member 8 Homo sapiens 89-93 33670955-5 2021 We showed that all three drugs significantly increased the accumulation of ubiquitinated OAT3, which was consistent with decreased intracellular 20S proteasomal activity; stimulated OAT3-mediated transport of estrone sulfate and p-aminohippuric acid; and increased OAT3 surface expression. p-Aminohippuric Acid 229-249 solute carrier family 22 member 8 Homo sapiens 182-186 33670955-5 2021 We showed that all three drugs significantly increased the accumulation of ubiquitinated OAT3, which was consistent with decreased intracellular 20S proteasomal activity; stimulated OAT3-mediated transport of estrone sulfate and p-aminohippuric acid; and increased OAT3 surface expression. p-Aminohippuric Acid 229-249 solute carrier family 22 member 8 Homo sapiens 182-186 32710584-11 2020 Specimens from patients treated with PD and PAHA showed a higher number of myofibroblasts (alpha-SMA+, P < .01), neo-angiogenesis (CD34+, P < .01), proliferating dermal cells (Ki67+, P < .01), proliferating keratinocytes (Ki67+, P < .01) and collagen type 1 deposition (P < .05). p-Aminohippuric Acid 44-48 actin alpha 1, skeletal muscle Homo sapiens 91-100 32710584-11 2020 Specimens from patients treated with PD and PAHA showed a higher number of myofibroblasts (alpha-SMA+, P < .01), neo-angiogenesis (CD34+, P < .01), proliferating dermal cells (Ki67+, P < .01), proliferating keratinocytes (Ki67+, P < .01) and collagen type 1 deposition (P < .05). p-Aminohippuric Acid 44-48 CD34 molecule Homo sapiens 131-135 32981893-5 2020 In structure-activity relationship analyses, removal of either the 3-halogen or 4-hydroxyl group from FAMT or its structural analog 3-iodo-alpha-methyl-l-tyrosine greatly decreased the interaction with OAT1, reducing the [14C]p-aminohippurate uptake inhibition and the efflux induction. p-Aminohippuric Acid 226-242 solute carrier family 22 member 6 Homo sapiens 202-206 33066667-3 2020 AhR, when binding with exogenous ligands (environmental pollutants such as polycylic aryl hydrocarbon (PAH), dioxins) or endogenous ligand indoxyl-sulfate (IS), has dual functions that are mediated by the nature of the binding ligand, binding time, and specific pathways of distinct ligands. p-Aminohippuric Acid 103-106 aryl hydrocarbon receptor Homo sapiens 0-3 32946259-7 2020 Because inhibition of autophagy and ROS is known to improve PAH, we examined the effect of TIGAR on PAH progression. p-Aminohippuric Acid 100-103 Trp53 induced glycolysis regulatory phosphatase Mus musculus 91-96 33076877-9 2020 Kaplan-Meier survival curves showed lower survival rate in patients with hyperuricemia than in patients with normouricemia, in both groups (CTD-PAH group p = 0.041, CTD-PH group p = 0.013). p-Aminohippuric Acid 144-147 CTD Homo sapiens 140-143 33078100-9 2020 Both TNFalpha and IL-8 in the aqueous humor of PAH group were transiently elevated 1wk post-operation and recovered to normal levels at 1 and 3mo post-operation. p-Aminohippuric Acid 47-50 tumor necrosis factor Homo sapiens 5-13 33078100-9 2020 Both TNFalpha and IL-8 in the aqueous humor of PAH group were transiently elevated 1wk post-operation and recovered to normal levels at 1 and 3mo post-operation. p-Aminohippuric Acid 47-50 C-X-C motif chemokine ligand 8 Homo sapiens 18-22 32927467-2 2020 We determined the diagnostic and prognostic value of IGF1 and IGFBP2 in pediatric PAH. p-Aminohippuric Acid 82-85 insulin like growth factor 1 Homo sapiens 53-57 32927467-2 2020 We determined the diagnostic and prognostic value of IGF1 and IGFBP2 in pediatric PAH. p-Aminohippuric Acid 82-85 insulin like growth factor binding protein 2 Homo sapiens 62-68 32927467-12 2020 1IGF1 AND IGFBP2 CONCENTRATION (NG/ML) IN PAH BIOBANK VERSUS CONTROLS. p-Aminohippuric Acid 42-45 insulin like growth factor binding protein 2 Homo sapiens 10-16 32927467-13 2020 : a IGF1 concentration (ng/mL) in PAH Biobank versus asthmatic subjects. p-Aminohippuric Acid 34-37 insulin like growth factor 1 Homo sapiens 4-8 32554275-9 2020 Toxicological results revealed that indoor and personal exposure to OC as well as PAH compounds and their derivatives (e.g., Alkyl-PAHs, Oxy-PAHs) induced cell viability reduction and increase in levels of LDH, IL-6, and 8-isoprostane. p-Aminohippuric Acid 82-85 interleukin 6 Homo sapiens 211-215 32855688-4 2020 The patients with CHD-PAH showed higher serum miR-27b, BNP and ADMA but lower miR-451 than the controls. p-Aminohippuric Acid 22-25 microRNA 27b Homo sapiens 46-53 32855688-4 2020 The patients with CHD-PAH showed higher serum miR-27b, BNP and ADMA but lower miR-451 than the controls. p-Aminohippuric Acid 22-25 natriuretic peptide B Homo sapiens 55-58 32855688-4 2020 The patients with CHD-PAH showed higher serum miR-27b, BNP and ADMA but lower miR-451 than the controls. p-Aminohippuric Acid 22-25 microRNA 451a Homo sapiens 78-85 32545683-1 2020 The aim of the current study was to investigate the simultaneous measurement of plasma p-aminohippuric acid (PAH) clearance as a potential marker to assess effective renal plasma flow (eRPF) and tubular secretion (TS), and the plasma clearance of iohexol (IOH) as a marker of the glomerular filtration rate in poultry species. p-Aminohippuric Acid 87-107 phenylalanine hydroxylase Gallus gallus 109-112 32863226-7 2020 Here we show that increased protein O-GlcNAc occurs on eNOS in PAH and Ser-615 appears to be a novel site of O-GlcNAc modification resulting in reduced eNOS dimerization. p-Aminohippuric Acid 63-66 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 36-44 32863226-7 2020 Here we show that increased protein O-GlcNAc occurs on eNOS in PAH and Ser-615 appears to be a novel site of O-GlcNAc modification resulting in reduced eNOS dimerization. p-Aminohippuric Acid 63-66 nitric oxide synthase 3 Homo sapiens 55-59 32255665-11 2020 These findings demonstrate in primary cells and in a knock-in mouse that the repurposed small molecule chemical chaperone, 4-PBA, might be a promising precision medicine approach to treat PAH in patients with specific subtypes of BMPR2 mutation involving cysteine substitutions in the ligand binding domain. p-Aminohippuric Acid 188-191 bone morphogenetic protein receptor type 2 Homo sapiens 230-235 32234809-6 2020 We showed that bortezomib and carfilzomib extremely increased the ubiquitinated OAT1, which correlated well with an enhanced OAT1-mediated transport of p-aminohippuric acid and an enhanced OAT1 surface expression. p-Aminohippuric Acid 152-172 solute carrier family 22 member 6 Homo sapiens 80-84 32234809-6 2020 We showed that bortezomib and carfilzomib extremely increased the ubiquitinated OAT1, which correlated well with an enhanced OAT1-mediated transport of p-aminohippuric acid and an enhanced OAT1 surface expression. p-Aminohippuric Acid 152-172 solute carrier family 22 member 6 Homo sapiens 125-129 32234809-6 2020 We showed that bortezomib and carfilzomib extremely increased the ubiquitinated OAT1, which correlated well with an enhanced OAT1-mediated transport of p-aminohippuric acid and an enhanced OAT1 surface expression. p-Aminohippuric Acid 152-172 solute carrier family 22 member 6 Homo sapiens 125-129 31836608-2 2020 The detoxification of PAHs by glucuronidation is well-characterized for the UDP-glycosyltransferase (UGT) 1A, 2A, and 2B subfamilies; however, the role of the UGT3A subfamily in PAH metabolism remains poorly understood. p-Aminohippuric Acid 22-25 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 76-120 32234376-3 2020 The aim of this study was to evaluate zinc finger protein A20 can alleviate PAH in hypoxia exposed mice. p-Aminohippuric Acid 76-79 tumor necrosis factor, alpha-induced protein 3 Mus musculus 58-61 32344570-8 2020 Acamprosate inhibited OAT1-mediated p-aminohippuric acid (PAH) uptake but did not inhibit substrate uptake via OAT3 expressing cells, neither when applied concomitantly nor after a 3 h preincubation with acamprosate. p-Aminohippuric Acid 36-56 solute carrier family 22 member 6 Homo sapiens 22-26 32344570-8 2020 Acamprosate inhibited OAT1-mediated p-aminohippuric acid (PAH) uptake but did not inhibit substrate uptake via OAT3 expressing cells, neither when applied concomitantly nor after a 3 h preincubation with acamprosate. p-Aminohippuric Acid 58-61 solute carrier family 22 member 6 Homo sapiens 22-26 32344570-9 2020 The uptake of PAH via OAT1 was inhibited in a competitive manner by acamprosate and cellular uptake studies showed that acamprosate is a substrate for OAT1 with a Km-value of approximately 700 microM. p-Aminohippuric Acid 14-17 solute carrier family 22 member 6 Homo sapiens 22-26 32344570-9 2020 The uptake of PAH via OAT1 was inhibited in a competitive manner by acamprosate and cellular uptake studies showed that acamprosate is a substrate for OAT1 with a Km-value of approximately 700 microM. p-Aminohippuric Acid 14-17 solute carrier family 22 member 6 Homo sapiens 151-155 32202428-3 2020 The thickness of two PAH/PSS bilayers on the Np-Ag was estimated to be ~ 4 nm (consistent with a literature value of ~1 nm per PAH or PSS layer) on the basis of a high-resolution transmission electron microscopy image of the Np-Ag(PAH/PSS)2. p-Aminohippuric Acid 21-24 phosphatidylserine synthase 2 Homo sapiens 235-240 32373203-4 2020 Probenecid, p-aminohippurate, and benzylpenicillin inhibited the uptake of imipenem and cilastatin in rat kidney slices and in hOAT1- and hOAT3-HEK 293 cells, respectively. p-Aminohippuric Acid 12-28 solute carrier family 22 member 6 Homo sapiens 127-132 32373203-4 2020 Probenecid, p-aminohippurate, and benzylpenicillin inhibited the uptake of imipenem and cilastatin in rat kidney slices and in hOAT1- and hOAT3-HEK 293 cells, respectively. p-Aminohippuric Acid 12-28 solute carrier family 22 member 8 Homo sapiens 138-143 31773853-5 2020 Moreover, the linkage points and the structure of the molecules have a noticeable effect on the transport properties of the PAH, making the odd-even effect weaker or disappear entirely. p-Aminohippuric Acid 124-127 odd-skipped related transcription factor 1 Homo sapiens 140-143 31836608-6 2020 The Vmax/Km ratios for UGT3A2 activity with UDP-xylose vs. UDP-glucose as cosubstrate ranged from 0.71-4.0 for all PAHs tested, demonstrating that PAH glycosylation may be occurring at rates up to four-fold higher with UDP-xylose than UDP-glucose. p-Aminohippuric Acid 115-118 UDP glycosyltransferase family 3 member A2 Homo sapiens 23-29 31884414-4 2020 The polyphenol oxidase (PPO) activity decreased in soils having Fire Phoenix, while the dehydrogenase (DHO) activity increased as the changes of DHO activity had a strong positive correlation with the removal rates of PAHs and Cd in the low-PAH soils (r = 0.862 (P < 0.006) and 0.913 (P < 0.002), respectively). p-Aminohippuric Acid 218-221 protoporphyrinogen oxidase Homo sapiens 4-22 31884414-4 2020 The polyphenol oxidase (PPO) activity decreased in soils having Fire Phoenix, while the dehydrogenase (DHO) activity increased as the changes of DHO activity had a strong positive correlation with the removal rates of PAHs and Cd in the low-PAH soils (r = 0.862 (P < 0.006) and 0.913 (P < 0.002), respectively). p-Aminohippuric Acid 218-221 protoporphyrinogen oxidase Homo sapiens 24-27 32019251-2 2020 Total PAH (particulate plus dissolved) concentrations in surface seawater were in the range 0.24-2.20 ng L-1 (mean 0.89 ng L-1), an order of magnitude lower than the mean values observed in the Japan Sea in 2008 and 2010. p-Aminohippuric Acid 6-9 immunoglobulin kappa variable 1-16 Homo sapiens 105-108 31850803-1 2020 RATIONALE: Insulin resistance and RV dysfunction is associated with lipotoxicity in heritable forms of PAH, commonly due to mutations in BMPR2. p-Aminohippuric Acid 103-106 insulin Homo sapiens 11-18 31850803-1 2020 RATIONALE: Insulin resistance and RV dysfunction is associated with lipotoxicity in heritable forms of PAH, commonly due to mutations in BMPR2. p-Aminohippuric Acid 103-106 bone morphogenetic protein receptor type 2 Homo sapiens 137-142 31850803-10 2020 MFGE8 driven signaling pathway may suggest a new mechanism underlying RV lipotoxicity in PAH. p-Aminohippuric Acid 89-92 milk fat globule EGF and factor V/VIII domain containing Homo sapiens 0-5 31818575-8 2020 Aromatics content contributed to more significant PAH-mediated IL-6 downregulation, whereas ethanol content was associated with decreased downregulation of IL-6. p-Aminohippuric Acid 50-53 interleukin 6 Homo sapiens 63-67 31685316-7 2020 The higher the PAH/PCB concentration in this sediment, the higher the bioaccessible fraction. p-Aminohippuric Acid 15-18 pyruvate carboxylase Homo sapiens 19-22 32028950-1 2020 OBJECTIVE: To investigate the differences in the proportions of BMPR2 mutations in familial hereditary pulmonary arterial hypertension (HPAH) and idiopathic pulmonary arterial hypertension (IPAH) between males and females and the relationship between BMPR2 mutation and PAH severity. p-Aminohippuric Acid 137-140 bone morphogenetic protein receptor type 2 Homo sapiens 64-69 32028950-7 2020 The risk of death or transplantation was higher in PAH patients with BMPR2 mutations than in those without (OR = 2.51, 95% CI: 1.29~3.57, P = 0.003, I2 = 24%). p-Aminohippuric Acid 51-54 bone morphogenetic protein receptor type 2 Homo sapiens 69-74 32028950-9 2020 CONCLUSION: Among patients with HPAH and IPAH, men are more likely to have BMPR2 mutations, which may predict more severe PAH indications and prognosis. p-Aminohippuric Acid 33-36 bone morphogenetic protein receptor type 2 Homo sapiens 75-80 32019251-2 2020 Total PAH (particulate plus dissolved) concentrations in surface seawater were in the range 0.24-2.20 ng L-1 (mean 0.89 ng L-1), an order of magnitude lower than the mean values observed in the Japan Sea in 2008 and 2010. p-Aminohippuric Acid 6-9 immunoglobulin kappa variable 1-16 Homo sapiens 123-126 31267273-5 2019 Expression of glycocalyx markers including heparin sulfate proteoglycan (HSPG), hyaluronan (HA), and syndecan-1 (SDC-1) was detected in monocrotaline (MCT)-induced PAH in rats and these components were detected when the PAH rats were treated with heparin that protected the role of glycocalyx. p-Aminohippuric Acid 164-167 syndecan 1 Rattus norvegicus 43-71 31662305-4 2020 RESEARCH DESIGN AND METHODS: Insulin sensitivity was assessed by hyperinsulinemic-euglycemic clamp (M value) (glucose infusion rate in mg/kglean/min) and renal hemodynamic function by urinary inulin (GFR) and para-aminohippuric acid (effective renal plasma flow [ERPF]) clearances in participants with T2D without overt kidney disease. p-Aminohippuric Acid 209-232 insulin Homo sapiens 29-36 31881747-11 2019 In the target genes-miRNA regulatory network and target genes-TF regulatory network (up and down regulated), TAOK1, KHSRP, HSD17B11 and PAH were target genes. p-Aminohippuric Acid 136-139 TAO kinase 1 Homo sapiens 109-114 31881747-11 2019 In the target genes-miRNA regulatory network and target genes-TF regulatory network (up and down regulated), TAOK1, KHSRP, HSD17B11 and PAH were target genes. p-Aminohippuric Acid 136-139 KH-type splicing regulatory protein Homo sapiens 116-121 31267273-5 2019 Expression of glycocalyx markers including heparin sulfate proteoglycan (HSPG), hyaluronan (HA), and syndecan-1 (SDC-1) was detected in monocrotaline (MCT)-induced PAH in rats and these components were detected when the PAH rats were treated with heparin that protected the role of glycocalyx. p-Aminohippuric Acid 164-167 syndecan 1 Rattus norvegicus 113-118 31763181-3 2019 We hypothesize that PAH mixture is more toxic than BaP alone, and an increased NOX2 activation is related to PAH-induced oxidative stress. p-Aminohippuric Acid 109-112 prohibitin 2 Homo sapiens 51-54 31763181-3 2019 We hypothesize that PAH mixture is more toxic than BaP alone, and an increased NOX2 activation is related to PAH-induced oxidative stress. p-Aminohippuric Acid 109-112 cytochrome b-245 beta chain Homo sapiens 79-83 31763181-6 2019 The higher concentration of BaP alone (500 ng/mL) and both 125 ng/mL and 500 ng/mL PAH mixture significantly (P < 0.05) increased lactate production by MDA-MB-231 cells. p-Aminohippuric Acid 83-86 prohibitin 2 Homo sapiens 28-31 31763181-9 2019 Colocalization of GP91phox and P47phox, a hallmark of NOX2 activation in the cell membrane of macrophage Kupffer cells demonstrated that higher concentration of BaP or PAH mixture showed increased colocalization events. p-Aminohippuric Acid 168-171 neutrophil cytosolic factor 1 Homo sapiens 31-38 31763181-9 2019 Colocalization of GP91phox and P47phox, a hallmark of NOX2 activation in the cell membrane of macrophage Kupffer cells demonstrated that higher concentration of BaP or PAH mixture showed increased colocalization events. p-Aminohippuric Acid 168-171 cytochrome b-245 beta chain Homo sapiens 54-58 31125610-10 2019 All of which deteriorated para-aminohippurate transport by down-regulating Oat1 during sudden ischaemia. p-Aminohippuric Acid 26-45 solute carrier family 22 member 6 Rattus norvegicus 75-79 31280357-9 2019 Among conventional risk factors for PAH, decreased DLCO may predict mPAP > 20 mmHg with priority in SSc patients. p-Aminohippuric Acid 36-39 phospholipid phosphatase 1 Mus musculus 68-72 31477116-4 2019 The aim of this study was to assess whether there was association between PAH exposure and the blood level of the acute phase inflammatory response marker serum amyloid A (SAA) in coke oven workers. p-Aminohippuric Acid 74-77 serum amyloid A1 cluster Homo sapiens 172-175 31477116-10 2019 CONCLUSIONS: Urinary 1-hydroxypyrene as biomarker of short-term PAH exposure and serum levels of CRP were predictive of serum levels of SAA in coke oven workers. p-Aminohippuric Acid 64-67 serum amyloid A1 cluster Homo sapiens 136-139 32186110-4 2019 The reabsorption of glucose and the excretion of para-aminohippuric acid (PAH) by HK-2 cells were also examined. p-Aminohippuric Acid 49-72 phenylalanine hydroxylase Homo sapiens 74-77 31477116-0 2019 Association between a urinary biomarker for exposure to PAH and blood level of the acute phase protein serum amyloid A in coke oven workers. p-Aminohippuric Acid 56-59 serum amyloid A1 cluster Homo sapiens 103-118 31477116-4 2019 The aim of this study was to assess whether there was association between PAH exposure and the blood level of the acute phase inflammatory response marker serum amyloid A (SAA) in coke oven workers. p-Aminohippuric Acid 74-77 serum amyloid A1 cluster Homo sapiens 155-170 30770717-9 2019 Patients with moderate to severe estimated systolic PAH had higher LOX levels (P < 0.01). p-Aminohippuric Acid 52-55 lysyl oxidase Homo sapiens 67-70 30770717-10 2019 Lung biopsies demonstrated intense LOX staining in SSc patients with PAH that was predominantly located in the endothelium of the remodelled pulmonary vessels. p-Aminohippuric Acid 69-72 lysyl oxidase Homo sapiens 35-38 30770717-12 2019 LOX is elevated in patients with moderate to severe PAH and is located in the proliferating endothelium in lung arterioles, suggesting a possible role for LOX in SSc-associated PAH. p-Aminohippuric Acid 52-55 lysyl oxidase Homo sapiens 0-3 30770717-12 2019 LOX is elevated in patients with moderate to severe PAH and is located in the proliferating endothelium in lung arterioles, suggesting a possible role for LOX in SSc-associated PAH. p-Aminohippuric Acid 177-180 lysyl oxidase Homo sapiens 0-3 31184465-7 2019 Although the active ingredients in the hydrogel cannot be quantitatively measured, the hydroxyl radical and NO3- are speculated to be the main components of PAH with antifungal activity according to ESR spectroscopy and optical emission spectroscopy. p-Aminohippuric Acid 157-160 NBL1, DAN family BMP antagonist Homo sapiens 108-111 31078851-0 2019 PM2.5-associated nitro-PAH exposure promotes tumor cell metastasis through Hippo-YAP mediated transcriptional regulation. p-Aminohippuric Acid 23-26 Yes1 associated transcriptional regulator Homo sapiens 81-84 30743243-4 2019 The wide variety of chemicals, including PAH and other related-chemicals, found in OEM, has been rather associated with early oxidative events, as supported by the early activation of the sensible NRF-2 signaling pathway. p-Aminohippuric Acid 41-44 NFE2 like bZIP transcription factor 2 Homo sapiens 197-202 30971116-14 2019 CONCLUSION: Maternal mortality and morbidity remain high in PAH-CHD patients, who should be counseled on the risks of pregnancy and managed in a tertiary multidisciplinary environment to improve prognosis. p-Aminohippuric Acid 60-63 choline dehydrogenase Homo sapiens 64-67 30917408-9 2019 SIGNIFICANCE OF THE STUDY: Hypoxia-induced upregulation of TGF-beta1 , PDGF, and HIF-1alpha plays a pivotal role in PAH, but molecular mechanism of how hypoxia regulates LOX expression is not clear. p-Aminohippuric Acid 116-119 transforming growth factor, beta 1 Rattus norvegicus 59-68 30917408-9 2019 SIGNIFICANCE OF THE STUDY: Hypoxia-induced upregulation of TGF-beta1 , PDGF, and HIF-1alpha plays a pivotal role in PAH, but molecular mechanism of how hypoxia regulates LOX expression is not clear. p-Aminohippuric Acid 116-119 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 81-91 29748060-11 2019 CONCLUSIONS: Pulmonary artery pulsatility index was independently associated with survival in PAH, highlighting the utility of PAPi in combination with other key measures for risk stratification in this population. p-Aminohippuric Acid 94-97 pyroglutamyl-peptidase I Homo sapiens 127-131 30639283-4 2019 The template shape was determined mainly through reciprocal comparisons of simulation results with available experiment data mainly on recombinant CYP3A4-mediated reactions of polyaromatic hydrocarbon (PAH) ligands. p-Aminohippuric Acid 202-205 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 147-153 30743243-7 2019 According to the high concentrations of PAH and other related organic chemicals found in this OEM, CYP1A1 and 1B1 genes exhibited high transcription levels in BEAS-2B cells, thereby supporting both the activation of the critical AhR signaling pathway and the formation of highly reactive ultimate metabolites. p-Aminohippuric Acid 40-43 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 99-113 30743243-7 2019 According to the high concentrations of PAH and other related organic chemicals found in this OEM, CYP1A1 and 1B1 genes exhibited high transcription levels in BEAS-2B cells, thereby supporting both the activation of the critical AhR signaling pathway and the formation of highly reactive ultimate metabolites. p-Aminohippuric Acid 40-43 aryl hydrocarbon receptor Homo sapiens 229-232 29648495-1 2019 Mice that were heterozygous dominant for the enu1 and enu2 mutation in phenylalanine monooxygenase/phenylalanine hydroxylase (PAH) resulted in hepatic PAH assays for S-carboxymethyl-L-cysteine (SCMC) that had significantly increased calculated Km (wild type (wt)/enu1, 1.84-2.12 fold increase and wt/enu2 a 2.75 fold increase in PAH assays). p-Aminohippuric Acid 126-129 phenylalanine hydroxylase Mus musculus 99-124 29648495-1 2019 Mice that were heterozygous dominant for the enu1 and enu2 mutation in phenylalanine monooxygenase/phenylalanine hydroxylase (PAH) resulted in hepatic PAH assays for S-carboxymethyl-L-cysteine (SCMC) that had significantly increased calculated Km (wild type (wt)/enu1, 1.84-2.12 fold increase and wt/enu2 a 2.75 fold increase in PAH assays). p-Aminohippuric Acid 151-154 phenylalanine hydroxylase Mus musculus 99-124 29648495-1 2019 Mice that were heterozygous dominant for the enu1 and enu2 mutation in phenylalanine monooxygenase/phenylalanine hydroxylase (PAH) resulted in hepatic PAH assays for S-carboxymethyl-L-cysteine (SCMC) that had significantly increased calculated Km (wild type (wt)/enu1, 1.84-2.12 fold increase and wt/enu2 a 2.75 fold increase in PAH assays). p-Aminohippuric Acid 151-154 phenylalanine hydroxylase Mus musculus 99-124 30669861-1 2019 IMPACT STATEMENT: Our article focuses on the pathogenesis and treatment of CTD-PAH. p-Aminohippuric Acid 79-82 CTD Homo sapiens 75-78 30669861-2 2019 In the latest ESC/ESR guidelines for PAH, the authors underline that although CTD-PAH should follow the same treatment protocol as idiopathic PAH, the therapeutic approach is more complex and difficult in the former. p-Aminohippuric Acid 37-40 CTD Homo sapiens 78-81 30669861-2 2019 In the latest ESC/ESR guidelines for PAH, the authors underline that although CTD-PAH should follow the same treatment protocol as idiopathic PAH, the therapeutic approach is more complex and difficult in the former. p-Aminohippuric Acid 82-85 CTD Homo sapiens 78-81 30669861-2 2019 In the latest ESC/ESR guidelines for PAH, the authors underline that although CTD-PAH should follow the same treatment protocol as idiopathic PAH, the therapeutic approach is more complex and difficult in the former. p-Aminohippuric Acid 82-85 CTD Homo sapiens 78-81 30669861-3 2019 This review throws light on several peculiar aspects of CTD-PAH and the latest findings in the pathogenesis, namely, the role of inflammation in the maladaptive right ventricle remodeling in SSc-PAH where immunosuppressants are classically believed to be ineffective. p-Aminohippuric Acid 60-63 CTD Homo sapiens 56-59 29244191-13 2018 Finally, the OAT1-substrate para-aminohippurate (PAH) showed some uptake (Km -value of 2.0 +- 0.4 mM) but did not interact with cyclic nucleotide or indomethacin transport. p-Aminohippuric Acid 28-47 solute carrier family 22 member 6 Homo sapiens 13-17 31807132-3 2019 The spectral shifts due to PAH clustering in argon matrices provide clues for the AIB contribution from PAH clusters in the interstellar medium. p-Aminohippuric Acid 27-30 ANIB1 Homo sapiens 82-85 31807132-3 2019 The spectral shifts due to PAH clustering in argon matrices provide clues for the AIB contribution from PAH clusters in the interstellar medium. p-Aminohippuric Acid 104-107 ANIB1 Homo sapiens 82-85 30409363-0 2018 Untangling BNP and BMI: Does Obesity Limit the Predictive Capability of BNP in PAH? p-Aminohippuric Acid 79-82 natriuretic peptide B Homo sapiens 72-75 30145463-2 2018 A method of increasing the fluorescence emission of Human Serum Albumin (HSA) encapsulated gold nanoclusters (AuNCs) via a Polyallylamide hydrochloride (PAH) coating is described. p-Aminohippuric Acid 153-156 albumin Homo sapiens 58-71 28945155-6 2018 OAT2 (transcript variant 1, OAT2-tv1) presented high uptake ratios of 30, 13, ~35, ~25, 8.5 and 9 with cGMP, PAH, penciclovir, ganciclovir, creatinine and E3S, respectively. p-Aminohippuric Acid 109-112 solute carrier family 22 member 7 Homo sapiens 0-4 28945155-6 2018 OAT2 (transcript variant 1, OAT2-tv1) presented high uptake ratios of 30, 13, ~35, ~25, 8.5 and 9 with cGMP, PAH, penciclovir, ganciclovir, creatinine and E3S, respectively. p-Aminohippuric Acid 109-112 solute carrier family 22 member 7 Homo sapiens 28-32 29244191-13 2018 Finally, the OAT1-substrate para-aminohippurate (PAH) showed some uptake (Km -value of 2.0 +- 0.4 mM) but did not interact with cyclic nucleotide or indomethacin transport. p-Aminohippuric Acid 49-52 solute carrier family 22 member 6 Homo sapiens 13-17 29587234-9 2018 An increase in Factor 1 (+Fe, +Al, +Mn) score and a decrease in Factor 2 (-Ca, +Pb, +PAH) score were associated with increased interleukin (IL)-6 (Factor 1; p = 0.010; Factor 2; p = 0.006) and IL-8 (Factor 1; p = 0.003; Factor 2; p = 0.020) production, however, only the association with Factor 1 was evident after correcting for endotoxin and particle size. p-Aminohippuric Acid 85-88 interleukin 6 Homo sapiens 127-145 30115106-11 2018 The combination of Midkine and FSTL3 can serve as an SSc-PAH biomarker and are potential drug targets for this rare disease population. p-Aminohippuric Acid 57-60 midkine Homo sapiens 19-26 30115106-11 2018 The combination of Midkine and FSTL3 can serve as an SSc-PAH biomarker and are potential drug targets for this rare disease population. p-Aminohippuric Acid 57-60 follistatin like 3 Homo sapiens 31-36 29418012-13 2018 DQ2 haplotype was detected in 50% of PAH and 38.4% of the control group (P = .3), while DQ8 haplotype in 25% of PAH and 7.2% of the control group (P = .01 OR:4.3 95%IC:1.3-14.7). p-Aminohippuric Acid 37-40 torsin family 1 member A Homo sapiens 0-3 29700402-0 2018 Selenoprotein P - a new player in PAH. p-Aminohippuric Acid 34-37 selenoprotein P Homo sapiens 0-15 29649319-2 2018 Treatment of HPASMC with vasoactive peptides, endothelin-1 (ET-1) and bradykinin (BK) but not angiotensin II, induced a temporal decrease in the electrical impedance profile mirroring constrictive morphological change of the cells which typically was more robust in PAH as opposed to non-PAH cells. p-Aminohippuric Acid 266-269 endothelin 1 Homo sapiens 46-58 29516280-6 2018 BAFF levels were higher in adults with arthritis [p = 0.018], weight loss [p = 0.007], and PAH [p = 0.004]. p-Aminohippuric Acid 91-94 TNF superfamily member 13b Homo sapiens 0-4 29516280-14 2018 BAFF levels may be useful as biomarker for PAH and arthritis. p-Aminohippuric Acid 43-46 TNF superfamily member 13b Homo sapiens 0-4 29108819-5 2018 GCN2 expression was quantified by Western blotting in 24 PVOD patients, 44 patients with pulmonary arterial hypertension (PAH; 23 bone morphogenetic protein receptor type II [BMPR2] mutation carriers, 21 non-carriers), and 3 experimental pulmonary hypertension models. p-Aminohippuric Acid 122-125 eukaryotic translation initiation factor 2 alpha kinase 4 Homo sapiens 0-4 29108819-8 2018 GCN2 expression was abolished in heritable PVOD (p < 0.0001), but also importantly decreased in sporadic PVOD (p = 0.03) as well as in heritable (p = 0.002) and idiopathic PAH (p = 0.003); moreover, GCN2 was abolished in 2 experimental pulmonary hypertension models and importantly decreased in 1 model (p < 0.0001 for all models). p-Aminohippuric Acid 175-178 eukaryotic translation initiation factor 2 alpha kinase 4 Homo sapiens 0-4 29649319-9 2018 However, inhibiting the activity of the sarcoplasmic reticulum Ca2+ ATPase blunted ET-1 and BK induced HPASMC contraction in both PAH and non-PAH derived HPASMC. p-Aminohippuric Acid 130-133 endothelin 1 Homo sapiens 83-87 29649319-2 2018 Treatment of HPASMC with vasoactive peptides, endothelin-1 (ET-1) and bradykinin (BK) but not angiotensin II, induced a temporal decrease in the electrical impedance profile mirroring constrictive morphological change of the cells which typically was more robust in PAH as opposed to non-PAH cells. p-Aminohippuric Acid 266-269 endothelin 1 Homo sapiens 60-64 29649319-9 2018 However, inhibiting the activity of the sarcoplasmic reticulum Ca2+ ATPase blunted ET-1 and BK induced HPASMC contraction in both PAH and non-PAH derived HPASMC. p-Aminohippuric Acid 130-133 kininogen 1 Homo sapiens 92-94 29649319-2 2018 Treatment of HPASMC with vasoactive peptides, endothelin-1 (ET-1) and bradykinin (BK) but not angiotensin II, induced a temporal decrease in the electrical impedance profile mirroring constrictive morphological change of the cells which typically was more robust in PAH as opposed to non-PAH cells. p-Aminohippuric Acid 266-269 kininogen 1 Homo sapiens 70-80 29649319-9 2018 However, inhibiting the activity of the sarcoplasmic reticulum Ca2+ ATPase blunted ET-1 and BK induced HPASMC contraction in both PAH and non-PAH derived HPASMC. p-Aminohippuric Acid 142-145 endothelin 1 Homo sapiens 83-87 29649319-2 2018 Treatment of HPASMC with vasoactive peptides, endothelin-1 (ET-1) and bradykinin (BK) but not angiotensin II, induced a temporal decrease in the electrical impedance profile mirroring constrictive morphological change of the cells which typically was more robust in PAH as opposed to non-PAH cells. p-Aminohippuric Acid 266-269 kininogen 1 Homo sapiens 82-84 29649319-9 2018 However, inhibiting the activity of the sarcoplasmic reticulum Ca2+ ATPase blunted ET-1 and BK induced HPASMC contraction in both PAH and non-PAH derived HPASMC. p-Aminohippuric Acid 142-145 kininogen 1 Homo sapiens 92-94 29649319-2 2018 Treatment of HPASMC with vasoactive peptides, endothelin-1 (ET-1) and bradykinin (BK) but not angiotensin II, induced a temporal decrease in the electrical impedance profile mirroring constrictive morphological change of the cells which typically was more robust in PAH as opposed to non-PAH cells. p-Aminohippuric Acid 288-291 endothelin 1 Homo sapiens 46-58 29649319-10 2018 In summary, our findings here together with previous communications illustrate similarities and differences in the regulation PAH and non-PAH smooth muscle cell contraction relating to calcium translocation, RhoA/ROCK signaling and the activity of caldesmon. p-Aminohippuric Acid 126-129 Rho associated coiled-coil containing protein kinase 1 Homo sapiens 213-217 29649319-2 2018 Treatment of HPASMC with vasoactive peptides, endothelin-1 (ET-1) and bradykinin (BK) but not angiotensin II, induced a temporal decrease in the electrical impedance profile mirroring constrictive morphological change of the cells which typically was more robust in PAH as opposed to non-PAH cells. p-Aminohippuric Acid 288-291 endothelin 1 Homo sapiens 60-64 29649319-2 2018 Treatment of HPASMC with vasoactive peptides, endothelin-1 (ET-1) and bradykinin (BK) but not angiotensin II, induced a temporal decrease in the electrical impedance profile mirroring constrictive morphological change of the cells which typically was more robust in PAH as opposed to non-PAH cells. p-Aminohippuric Acid 288-291 kininogen 1 Homo sapiens 70-80 29649319-10 2018 In summary, our findings here together with previous communications illustrate similarities and differences in the regulation PAH and non-PAH smooth muscle cell contraction relating to calcium translocation, RhoA/ROCK signaling and the activity of caldesmon. p-Aminohippuric Acid 138-141 Rho associated coiled-coil containing protein kinase 1 Homo sapiens 213-217 29649319-2 2018 Treatment of HPASMC with vasoactive peptides, endothelin-1 (ET-1) and bradykinin (BK) but not angiotensin II, induced a temporal decrease in the electrical impedance profile mirroring constrictive morphological change of the cells which typically was more robust in PAH as opposed to non-PAH cells. p-Aminohippuric Acid 288-291 kininogen 1 Homo sapiens 82-84 29649319-6 2018 While the regulation of ET-1 induced cell contraction was found to be similar in PAH and non-PAH cells, a key difference was the response to pharmacological inhibitors and to siRNA knockdown of Rho kinases (ROCK1/ROCK2). p-Aminohippuric Acid 81-84 endothelin 1 Homo sapiens 24-28 29649319-6 2018 While the regulation of ET-1 induced cell contraction was found to be similar in PAH and non-PAH cells, a key difference was the response to pharmacological inhibitors and to siRNA knockdown of Rho kinases (ROCK1/ROCK2). p-Aminohippuric Acid 93-96 endothelin 1 Homo sapiens 24-28 29649319-7 2018 The PAH cells required much higher concentrations of inhibitors to abrogate ET-1 induced contractions and their contraction was not affected by siRNA against either ROCK1 or ROCK2. p-Aminohippuric Acid 4-7 endothelin 1 Homo sapiens 76-80 29521190-4 2018 The importance of understanding the mechanisms by which BMPR2 mutations cause disease in patients with HPAH is underscored by evidence that there is reduced BMPR2 expression in patients with other, more common, non-hereditary form of PAH, and that restoration of BMPR2 expression reverses established disease in experimental models of pulmonary hypertension. p-Aminohippuric Acid 104-107 bone morphogenetic protein receptor type 2 Homo sapiens 56-61 29432661-6 2018 Experimental studies have also revealed that PPAR gamma activation affects many different pathways; thus, the effect of PPAR gamma is multifaceted, affecting almost every pathobiological pathway involved in the development of PAH simultaneously. p-Aminohippuric Acid 226-229 peroxisome proliferator activated receptor gamma Homo sapiens 45-55 29432661-6 2018 Experimental studies have also revealed that PPAR gamma activation affects many different pathways; thus, the effect of PPAR gamma is multifaceted, affecting almost every pathobiological pathway involved in the development of PAH simultaneously. p-Aminohippuric Acid 226-229 peroxisome proliferator activated receptor gamma Homo sapiens 120-130 29436232-10 2018 PAH uptake was completely blocked by 3 mM cephalothin (inhibits both oat1 and oat3), while 17% of PAH uptake was inhibited by 0.2 mM cephalothin (selectively inhibits oat3). p-Aminohippuric Acid 0-3 solute carrier family 22 member 6 Rattus norvegicus 69-73 29854032-6 2018 Compared with the sham control, TAC-induced PAH markedly upregulated the expression of EZH2 and ROS deposition in lungs in PAH mice. p-Aminohippuric Acid 44-47 enhancer of zeste 2 polycomb repressive complex 2 subunit Mus musculus 87-91 29854032-6 2018 Compared with the sham control, TAC-induced PAH markedly upregulated the expression of EZH2 and ROS deposition in lungs in PAH mice. p-Aminohippuric Acid 123-126 enhancer of zeste 2 polycomb repressive complex 2 subunit Mus musculus 87-91 29854032-7 2018 The inhibiter of methyltransferase EZH2, EPZ005687 significantly inhibits the development of TAC-induced PAH in an EZH2-SOD1-ROS dependent manner. p-Aminohippuric Acid 105-108 enhancer of zeste 2 polycomb repressive complex 2 subunit Mus musculus 35-39 29854032-7 2018 The inhibiter of methyltransferase EZH2, EPZ005687 significantly inhibits the development of TAC-induced PAH in an EZH2-SOD1-ROS dependent manner. p-Aminohippuric Acid 105-108 enhancer of zeste 2 polycomb repressive complex 2 subunit Mus musculus 115-119 29854032-7 2018 The inhibiter of methyltransferase EZH2, EPZ005687 significantly inhibits the development of TAC-induced PAH in an EZH2-SOD1-ROS dependent manner. p-Aminohippuric Acid 105-108 superoxide dismutase 1, soluble Mus musculus 120-124 29854032-8 2018 Conclusion: Our data identified that EZH2 serves a fundamental role in TAC-induced PAH, and administration of EPZ005687 might represent a novel therapeutic target for the treatment of TAC-induced PAH. p-Aminohippuric Acid 83-86 enhancer of zeste 2 polycomb repressive complex 2 subunit Mus musculus 37-41 29285766-1 2018 Recent studies have clarified that pulmonary arterial hypertension associated with connective tissue diseases (CTD-PAH) has some distinctive clinical aspects from other PAH, such as high prevalence, venous and cardiac involvement, less favourable outcome, helpfulness of detection algorithm, response to immunosuppression, pre-PAH conditions in borderline pulmonary arterial pressure and coexistence of interstitial lung disease. p-Aminohippuric Acid 115-118 CTD Homo sapiens 111-114 29285766-1 2018 Recent studies have clarified that pulmonary arterial hypertension associated with connective tissue diseases (CTD-PAH) has some distinctive clinical aspects from other PAH, such as high prevalence, venous and cardiac involvement, less favourable outcome, helpfulness of detection algorithm, response to immunosuppression, pre-PAH conditions in borderline pulmonary arterial pressure and coexistence of interstitial lung disease. p-Aminohippuric Acid 169-172 CTD Homo sapiens 111-114 29568443-4 2017 However, for B-triisopropylphenyl (Trip) PAH congeners oxidation has to be performed prior to Trip installation due to preferential oxidation of an isopropylaryl moiety to the styrene. p-Aminohippuric Acid 41-44 LRR binding FLII interacting protein 1 Homo sapiens 13-33 29105795-10 2018 CONCLUSIONS: Our results may suggest a possible pathway through which PAH develops directly into prostate cancer in the presence of CD4+ Tregs and indicate that transformation of the anti-tumor immune response may be initiated even before the primary tumor is established. p-Aminohippuric Acid 70-73 CD4 molecule Homo sapiens 132-135 29801672-8 2018 After adjusting for age, sex and hs-CRP, the diagnosis of CTD-PAH was still associated with ID (OR = 3.01, 95%CI 1.02-8.90, P < 0.05). p-Aminohippuric Acid 62-65 CTD Homo sapiens 58-61 29801672-10 2018 CTD-PAH is independently associated with ID, after adjustment for age, sex, and hs-CRP. p-Aminohippuric Acid 4-7 CTD Homo sapiens 0-3 29261014-0 2018 Selective improvement of pulmonary arterial hypertension with a dual ETA/ETB receptors antagonist in the apolipoprotein E-/- model of PAH and atherosclerosis. p-Aminohippuric Acid 134-137 endothelin receptor type A Mus musculus 69-72 29261014-0 2018 Selective improvement of pulmonary arterial hypertension with a dual ETA/ETB receptors antagonist in the apolipoprotein E-/- model of PAH and atherosclerosis. p-Aminohippuric Acid 134-137 endothelin receptor type B Mus musculus 73-76 29261014-0 2018 Selective improvement of pulmonary arterial hypertension with a dual ETA/ETB receptors antagonist in the apolipoprotein E-/- model of PAH and atherosclerosis. p-Aminohippuric Acid 134-137 apolipoprotein E Mus musculus 105-121 29261014-2 2018 Apolipoprotein E-deficient (ApoE-/-) mice develop atherosclerosis with severe PAH when fed a high-fat diet (HFD) and have increased levels of endothelin (ET)-1. p-Aminohippuric Acid 78-81 apolipoprotein E Mus musculus 28-32 29261014-11 2018 Dual blockade of ETA/ETB receptors improves endothelial function and improves experimental PAH but had no significant effect on atherosclerosis. p-Aminohippuric Acid 91-94 endothelin receptor type A Mus musculus 17-20 29261014-11 2018 Dual blockade of ETA/ETB receptors improves endothelial function and improves experimental PAH but had no significant effect on atherosclerosis. p-Aminohippuric Acid 91-94 endothelin receptor type B Mus musculus 21-24 29568443-4 2017 However, for B-triisopropylphenyl (Trip) PAH congeners oxidation has to be performed prior to Trip installation due to preferential oxidation of an isopropylaryl moiety to the styrene. p-Aminohippuric Acid 41-44 LRR binding FLII interacting protein 1 Homo sapiens 35-39 28819713-2 2017 Plasma GDF-15 levels were measured in children with PAH-CHD (n = 46) and compared to children with CHD without PAH (n = 39). p-Aminohippuric Acid 52-55 growth differentiation factor 15 Homo sapiens 7-13 28819713-4 2017 Plasma GDF-15 levels were significantly elevated in patients with PAH-CHD compared with those with CHD without PAH (median 1415 ng/L, interquartile range [IQR] 926.7-2111.7 ng/L vs. 890.6 ng/L, IQR 394.7-1094.3 ng/L, p < 0.01). p-Aminohippuric Acid 66-69 growth differentiation factor 15 Homo sapiens 7-13 28819713-4 2017 Plasma GDF-15 levels were significantly elevated in patients with PAH-CHD compared with those with CHD without PAH (median 1415 ng/L, interquartile range [IQR] 926.7-2111.7 ng/L vs. 890.6 ng/L, IQR 394.7-1094.3 ng/L, p < 0.01). p-Aminohippuric Acid 111-114 growth differentiation factor 15 Homo sapiens 7-13 28819713-8 2017 Plasma GDF-15 levels might be a surrogate marker for pediatric PAH-CHD. p-Aminohippuric Acid 63-66 growth differentiation factor 15 Homo sapiens 7-13 28789830-3 2017 Therefore, SphK1 might be a novel target for treatment of PAH. p-Aminohippuric Acid 58-61 sphingosine kinase 1 Homo sapiens 11-16 29312590-7 2017 FAH was positively correlated with Ht at start, and end of GnRHa, PAH at start and end of GnRHa, and also with midparent height (R2 =0.59, 0.74, 0.68, 0.73 and 0.80, P<0.001). p-Aminohippuric Acid 66-69 fumarylacetoacetate hydrolase Homo sapiens 0-3 28749191-13 2017 Anti-Topo I and anti-NOR90 abs are associated with ILD and/or PAH. p-Aminohippuric Acid 62-65 upstream binding transcription factor Homo sapiens 21-26 28776262-4 2017 We tested the hypothesis that vaspin could prevent development of PAH in animal model. p-Aminohippuric Acid 66-69 serpin family A member 12 Rattus norvegicus 30-36 28776262-13 2017 In summary, we for the first time demonstrate that vaspin prevents MCT-induced PAH at least in part via inhibiting ROS/MMP-2/fibrosis pathway. p-Aminohippuric Acid 79-82 serpin family A member 12 Rattus norvegicus 51-57 29156656-0 2017 VEGFR3 as a novel modulator for PAH. p-Aminohippuric Acid 32-35 fms related receptor tyrosine kinase 4 Homo sapiens 0-6 29050128-5 2017 There are 6 cases are CTD-ILD-PAH patients of all. p-Aminohippuric Acid 30-33 CTD Homo sapiens 22-25 28902925-9 2017 This phenomenon may be mediated by increased tyrosine phosphorylation of Kv1.5 in PASMCs and it provides new insight into the prevention and treatment of IUGR-related CH-PAH. p-Aminohippuric Acid 170-173 potassium voltage-gated channel subfamily A member 5 Rattus norvegicus 73-78 28789830-4 2017 However, in our opinion, more refined strategies to target SphK1 are needed because this enzyme is protective against endothelial dysfunction and can become resistant to SphK1 inhibitors in vascular smooth muscle, thereby potentially limiting their effectiveness in PAH. p-Aminohippuric Acid 266-269 sphingosine kinase 1 Homo sapiens 59-64 28790444-7 2017 Active SLE patients positive for anti-SmD1 were more likely to have malar rash, rash, nonscarring alopecia, PAH and hypocomplementemia. p-Aminohippuric Acid 108-111 small nuclear ribonucleoprotein D1 polypeptide Homo sapiens 38-42 28619995-6 2017 Both BMP4- and TGFbeta1-stimulated elastic fiber assembly was impaired in idiopathic (I) PAH-PA adventitial fibroblast versus control cells, particularly those with hereditary (H) PAH and a BMPR2 mutation. p-Aminohippuric Acid 89-92 bone morphogenetic protein 4 Mus musculus 5-9 28619995-6 2017 Both BMP4- and TGFbeta1-stimulated elastic fiber assembly was impaired in idiopathic (I) PAH-PA adventitial fibroblast versus control cells, particularly those with hereditary (H) PAH and a BMPR2 mutation. p-Aminohippuric Acid 89-92 transforming growth factor, beta 1 Mus musculus 15-23 28725652-0 2017 Rescuing BMPR2-driven endothelial dysfunction in PAH: a novel treatment strategy for the future? p-Aminohippuric Acid 49-52 bone morphogenetic protein receptor type 2 Homo sapiens 9-14 28671485-1 2017 Patients with pulmonary arterial hypertension associated with connective tissue disease (PAH-PAH-CTD) such as systemic sclerosis (SSc) have a poorer response to treatment and increased mortality compared with patients with idiopathic PAH. p-Aminohippuric Acid 89-92 CTD Homo sapiens 97-100 28671485-1 2017 Patients with pulmonary arterial hypertension associated with connective tissue disease (PAH-PAH-CTD) such as systemic sclerosis (SSc) have a poorer response to treatment and increased mortality compared with patients with idiopathic PAH. p-Aminohippuric Acid 93-96 CTD Homo sapiens 97-100 28671485-1 2017 Patients with pulmonary arterial hypertension associated with connective tissue disease (PAH-PAH-CTD) such as systemic sclerosis (SSc) have a poorer response to treatment and increased mortality compared with patients with idiopathic PAH. p-Aminohippuric Acid 93-96 CTD Homo sapiens 97-100 28671485-2 2017 Current treatment options for PAH-CTD include prostanoids, phosphodiesterase type-5 inhibitors (PDE-5i), endothelin receptor antagonists, and the soluble guanylate cyclase stimulator riociguat. p-Aminohippuric Acid 30-33 CTD Homo sapiens 34-37 28671485-3 2017 In this case series, we describe three patients with PAH-CTD related to limited scleroderma who were switched from a PDE-5i to riociguat due to insufficient clinical response. p-Aminohippuric Acid 53-56 CTD Homo sapiens 57-60 28671485-5 2017 These cases demonstrate that switching to riociguat is a therapeutic option in patients with PAH-CTD who have not achieved a satisfactory clinical response to a PDE-5i. p-Aminohippuric Acid 93-96 CTD Homo sapiens 97-100 28733583-5 2017 Through RT-PCR, Western blot and ELISA examination, NF-kappaB, IL-6, TNF-alpha, and iNOS were found to be significantly reduced in PAH rats treated with T0901317 compared to PAH rats treated with DMSO. p-Aminohippuric Acid 131-134 interleukin 6 Rattus norvegicus 63-67 28733583-5 2017 Through RT-PCR, Western blot and ELISA examination, NF-kappaB, IL-6, TNF-alpha, and iNOS were found to be significantly reduced in PAH rats treated with T0901317 compared to PAH rats treated with DMSO. p-Aminohippuric Acid 131-134 tumor necrosis factor Rattus norvegicus 69-78 28733583-5 2017 Through RT-PCR, Western blot and ELISA examination, NF-kappaB, IL-6, TNF-alpha, and iNOS were found to be significantly reduced in PAH rats treated with T0901317 compared to PAH rats treated with DMSO. p-Aminohippuric Acid 131-134 nitric oxide synthase 2 Rattus norvegicus 84-88 27373854-9 2017 Patients with idiopathic PAH (IPAH) demonstrate increased circulating and tissue levels of OPG, and circulating serum levels predict survival. p-Aminohippuric Acid 25-28 TNF receptor superfamily member 11b Homo sapiens 91-94 28496318-7 2017 In conclusion, the presence of rs531564 minor allele may increase the risk of PAH in COPD by reducing miR-124 expression, increasing GRB2 expression, and promoting the proliferation of PASMCs. p-Aminohippuric Acid 78-81 growth factor receptor bound protein 2 Homo sapiens 133-137 27614971-3 2017 The prototypical substrate for renal organic anion transport systems, para-aminohippurate (PAH), is transported across basolateral membranes of proximal tubular cells via OAT1 (SLC22A6) and OAT3 (SLC22A8) against an electrochemical gradient in exchange for intracellular dicarboxylates. p-Aminohippuric Acid 70-89 solute carrier family 22 member 6 Homo sapiens 171-175 27614971-3 2017 The prototypical substrate for renal organic anion transport systems, para-aminohippurate (PAH), is transported across basolateral membranes of proximal tubular cells via OAT1 (SLC22A6) and OAT3 (SLC22A8) against an electrochemical gradient in exchange for intracellular dicarboxylates. p-Aminohippuric Acid 70-89 solute carrier family 22 member 6 Homo sapiens 177-184 27614971-3 2017 The prototypical substrate for renal organic anion transport systems, para-aminohippurate (PAH), is transported across basolateral membranes of proximal tubular cells via OAT1 (SLC22A6) and OAT3 (SLC22A8) against an electrochemical gradient in exchange for intracellular dicarboxylates. p-Aminohippuric Acid 70-89 solute carrier family 22 member 8 Homo sapiens 190-194 27614971-3 2017 The prototypical substrate for renal organic anion transport systems, para-aminohippurate (PAH), is transported across basolateral membranes of proximal tubular cells via OAT1 (SLC22A6) and OAT3 (SLC22A8) against an electrochemical gradient in exchange for intracellular dicarboxylates. p-Aminohippuric Acid 70-89 solute carrier family 22 member 8 Homo sapiens 196-203 27614971-3 2017 The prototypical substrate for renal organic anion transport systems, para-aminohippurate (PAH), is transported across basolateral membranes of proximal tubular cells via OAT1 (SLC22A6) and OAT3 (SLC22A8) against an electrochemical gradient in exchange for intracellular dicarboxylates. p-Aminohippuric Acid 91-94 solute carrier family 22 member 6 Homo sapiens 171-175 27614971-3 2017 The prototypical substrate for renal organic anion transport systems, para-aminohippurate (PAH), is transported across basolateral membranes of proximal tubular cells via OAT1 (SLC22A6) and OAT3 (SLC22A8) against an electrochemical gradient in exchange for intracellular dicarboxylates. p-Aminohippuric Acid 91-94 solute carrier family 22 member 6 Homo sapiens 177-184 27614971-3 2017 The prototypical substrate for renal organic anion transport systems, para-aminohippurate (PAH), is transported across basolateral membranes of proximal tubular cells via OAT1 (SLC22A6) and OAT3 (SLC22A8) against an electrochemical gradient in exchange for intracellular dicarboxylates. p-Aminohippuric Acid 91-94 solute carrier family 22 member 8 Homo sapiens 190-194 27614971-3 2017 The prototypical substrate for renal organic anion transport systems, para-aminohippurate (PAH), is transported across basolateral membranes of proximal tubular cells via OAT1 (SLC22A6) and OAT3 (SLC22A8) against an electrochemical gradient in exchange for intracellular dicarboxylates. p-Aminohippuric Acid 91-94 solute carrier family 22 member 8 Homo sapiens 196-203 28696839-7 2017 UGT1A (rs11892031[A/A]) was found frequently in cases exposed to carbolineum, crack test spray, PAH, and in painters and varnishers. p-Aminohippuric Acid 96-99 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 0-5 28379700-7 2017 However, upon rinsing with PAH, very thin CaM-PAH sublayers remain. p-Aminohippuric Acid 27-30 calmodulin 1 Homo sapiens 42-45 28379700-7 2017 However, upon rinsing with PAH, very thin CaM-PAH sublayers remain. p-Aminohippuric Acid 46-49 calmodulin 1 Homo sapiens 42-45 28379700-8 2017 There are no indications that ligand TFP can be involved in the multilayer buildup due to strong CaM-PAH interactions. p-Aminohippuric Acid 101-104 calmodulin 1 Homo sapiens 97-100 27816282-8 2017 Chemical analysis revealed that PAH components are correlated with AhR-binding activities. p-Aminohippuric Acid 32-35 aryl hydrocarbon receptor Homo sapiens 67-70 28069864-5 2017 These results suggested that Hdz inhibited the MAO-B activity and consequently tMH increased in the maternal circulation of PAH mice. p-Aminohippuric Acid 124-127 monoamine oxidase B Mus musculus 47-52 28084316-6 2017 We confirm this signalling switch in rodent models of PAH and demonstrate that anti-TNFalpha immunotherapy reverses disease progression, restoring normal BMP/NOTCH signalling. p-Aminohippuric Acid 54-57 tumor necrosis factor Homo sapiens 84-92 28084316-7 2017 Collectively, these findings identify mechanisms by which BMP and TNFalpha signalling contribute to disease, and suggest a tractable approach for therapeutic intervention in PAH. p-Aminohippuric Acid 174-177 bone morphogenetic protein 1 Homo sapiens 58-61 27373854-12 2017 Further pre-clinical and mechanistic data are forthcoming, but we believe current published data identify OPG as an exciting and novel therapeutic target in PAH. p-Aminohippuric Acid 157-160 TNF receptor superfamily member 11b Homo sapiens 106-109 27618022-4 2016 PhN is very similar in structure to phenanthrene (PhE), a well-studied poly aromatic hydrocarbon (PAH) known to cause toxicity in aquatic animals by activating the aryl hydrocarbon receptor (AhR). p-Aminohippuric Acid 98-101 aryl hydrocarbon receptor 1a Danio rerio 164-189 27737815-11 2016 RESULTS: After 28 days, as compared with that in normal control group, animals living in the chamber (PAH group) showed a significant increase in mPAP( 47.5mmHg versus 18mmHg), RV/LV+IVS (0.45 versus 0.21) and MA% (78% versus 44%), respectively. p-Aminohippuric Acid 102-105 phospholipid phosphatase 1 Mus musculus 146-150 28090303-2 2016 However, only 30% of BMPR2 mutation carriers develop PAH, and we cannot predict which of these carriers will develop clinical disease. p-Aminohippuric Acid 53-56 bone morphogenetic protein receptor, type II (serine/threonine kinase) Mus musculus 21-26 27816994-1 2016 Mutations in the bone morphogenetic protein receptor (BMPR2) gene have been observed in 70 % of patients with heritable pulmonary arterial hypertension (HPAH) and in 11-40 % with idiopathic PAH (IPAH). p-Aminohippuric Acid 154-157 bone morphogenetic protein receptor type 2 Homo sapiens 54-59 27816994-2 2016 However, carriers of a BMPR2 mutation have only 20 % risk of developing PAH. p-Aminohippuric Acid 72-75 bone morphogenetic protein receptor type 2 Homo sapiens 23-28 27816994-3 2016 Since inflammatory mediators are increased and predict survival in PAH, they could act as a second hit inducing the development of pulmonary hypertension in BMPR2 mutation carriers. p-Aminohippuric Acid 67-70 bone morphogenetic protein receptor type 2 Homo sapiens 157-162 27816994-10 2016 PMEC from BMPR2 mutation carriers have enhanced adhesiveness for monocytes in response to inflammatory mediators, suggesting that BMPR2 mutation could generate susceptibility to an inflammatory insult in PAH. p-Aminohippuric Acid 204-207 bone morphogenetic protein receptor type 2 Homo sapiens 10-15 27816994-10 2016 PMEC from BMPR2 mutation carriers have enhanced adhesiveness for monocytes in response to inflammatory mediators, suggesting that BMPR2 mutation could generate susceptibility to an inflammatory insult in PAH. p-Aminohippuric Acid 204-207 bone morphogenetic protein receptor type 2 Homo sapiens 130-135 27618022-4 2016 PhN is very similar in structure to phenanthrene (PhE), a well-studied poly aromatic hydrocarbon (PAH) known to cause toxicity in aquatic animals by activating the aryl hydrocarbon receptor (AhR). p-Aminohippuric Acid 98-101 aryl hydrocarbon receptor 1a Danio rerio 191-194 27618022-6 2016 Morpholino knock-down of the AhR rescues the effects of PhN that are shared with PhE, suggesting these are due to PAH toxicity. p-Aminohippuric Acid 114-117 aryl hydrocarbon receptor 1a Danio rerio 29-32 26774701-11 2016 Decreased pyruvate kinase M2 activity confers additional advantages to rat PASMCs by allowing them to sustain anti-oxidant responses and thereby support cell survival in PAH. p-Aminohippuric Acid 170-173 pyruvate kinase M1/2 Rattus norvegicus 10-28 27008032-6 2016 An intracellular degradation study of both types of composite capsules revealed that PARG/DEXS/silica capsules were degraded into fragments and lead to the release of model molecules in a relatively short time (2 h), while the structure of PAH/PSS/silica capsules remained intact even after 3 days incubation with B50 cells. p-Aminohippuric Acid 240-243 poly(ADP-ribose) glycohydrolase Homo sapiens 85-89 27097580-7 2016 RESULTS: The non-PAH group had the highest serum level of apelin before and after surgery, followed by the mild PAH group, moderate PAH group, and severe PAH group (P<0.05). p-Aminohippuric Acid 17-20 apelin Homo sapiens 58-64 27010815-8 2016 Our study reveals a novel mechanism of hypoxia-induced pulmonary vascular remodeling, suggesting a new therapeutic strategy which is targeting on the positive feedback of ROS/mROS-DRP1 for the treatment of PAH. p-Aminohippuric Acid 206-209 dynamin 1 like Homo sapiens 180-184 27060237-5 2016 Concurrently, PAH and VA significantly interacted in their effects on CYP1A phase I biotransformation as observed from increased ethoxyresorufin-O-deethylase (EROD) activity, increased CYP1A protein concentration, and elevated transcription (cyp1a1 gene expression) in fish fed PAH+VA compared to PAH alone. p-Aminohippuric Acid 14-17 cytochrome P450, family 1, subfamily A Salmo salar 70-75 27060237-5 2016 Concurrently, PAH and VA significantly interacted in their effects on CYP1A phase I biotransformation as observed from increased ethoxyresorufin-O-deethylase (EROD) activity, increased CYP1A protein concentration, and elevated transcription (cyp1a1 gene expression) in fish fed PAH+VA compared to PAH alone. p-Aminohippuric Acid 14-17 cytochrome P450, family 1, subfamily A Salmo salar 185-190 27060237-5 2016 Concurrently, PAH and VA significantly interacted in their effects on CYP1A phase I biotransformation as observed from increased ethoxyresorufin-O-deethylase (EROD) activity, increased CYP1A protein concentration, and elevated transcription (cyp1a1 gene expression) in fish fed PAH+VA compared to PAH alone. p-Aminohippuric Acid 278-281 cytochrome P450, family 1, subfamily A Salmo salar 70-75 27060237-5 2016 Concurrently, PAH and VA significantly interacted in their effects on CYP1A phase I biotransformation as observed from increased ethoxyresorufin-O-deethylase (EROD) activity, increased CYP1A protein concentration, and elevated transcription (cyp1a1 gene expression) in fish fed PAH+VA compared to PAH alone. p-Aminohippuric Acid 278-281 cytochrome P450, family 1, subfamily A Salmo salar 70-75 27060237-9 2016 In conclusion, dietary VA interacted with PAH toxicity on the level of CYP1A-mediated detoxification, hepatic PAH accumulation, energy allocation, and growth. p-Aminohippuric Acid 42-45 cytochrome P450, family 1, subfamily A Salmo salar 71-76 26897077-3 2016 Cystatin C, a novel cardiac biomarker, correlates with right ventricular dimensions in patients with idiopathic PAH, giving it potential to determine prognosis in PAH-CHD patients. p-Aminohippuric Acid 112-115 cystatin C Homo sapiens 0-10 26897077-3 2016 Cystatin C, a novel cardiac biomarker, correlates with right ventricular dimensions in patients with idiopathic PAH, giving it potential to determine prognosis in PAH-CHD patients. p-Aminohippuric Acid 163-166 cystatin C Homo sapiens 0-10 26897077-13 2016 CONCLUSIONS: Cystatin C, a novel cardiac biomarker, predicts long-term mortality and clinical events in patients with PAH-CHD. p-Aminohippuric Acid 118-121 cystatin C Homo sapiens 13-23 26890333-3 2016 We demonstrated in PAH the increased frequency of the functional form of KIR2DS4-Full Length (KIR2DS4-FL), which in combination with HLA-DRB1*1301 revealed a strong synergistic effect (odds ratio=36.5). p-Aminohippuric Acid 19-22 killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 4 Homo sapiens 73-80 26890333-3 2016 We demonstrated in PAH the increased frequency of the functional form of KIR2DS4-Full Length (KIR2DS4-FL), which in combination with HLA-DRB1*1301 revealed a strong synergistic effect (odds ratio=36.5). p-Aminohippuric Acid 19-22 killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 4 Homo sapiens 94-101 26774701-12 2016 It may become a novel treatment strategy in PAH by using of PKM2 activators. p-Aminohippuric Acid 44-47 pyruvate kinase M1/2 Rattus norvegicus 60-64 27687597-5 2016 PAH (PH group 1) can be treated with agents targeting three dysfunctional endothelial pathways of PAH: nitric oxide (NO) pathway, endothelin-1 pathway and prostacyclin pathway. p-Aminohippuric Acid 0-3 endothelin 1 Homo sapiens 130-142 26322414-10 2015 CONCLUSION: EC-SOD is critical in preserving normal lung development and loss of EC-SOD results in disrupted alveolar development, PAH and vascular remodeling at baseline, which is further worsened with bleomycin and associated with decreased activation of VEGFR2. p-Aminohippuric Acid 131-134 superoxide dismutase 3, extracellular Mus musculus 12-18 26752193-3 2016 Higher levels of ET-1 predict disease severity and mortality in other forms of PAH, and endothelin receptor antagonists are central to treatment, including in HIV-associated PAH. p-Aminohippuric Acid 79-82 endothelin 1 Homo sapiens 17-21 26752193-4 2016 The direct relationship between ET-1 and PAH in HIV-infected individuals is not well described. p-Aminohippuric Acid 41-44 endothelin 1 Homo sapiens 32-36 26752193-9 2016 ET-1 was significantly associated with higher values of PASP [14% per 0.1 pg/mL increase in ET-1, p = 0.05] and PASP >= 30 mmHg [PR (prevalence ratio) = 1.24, p = 0.012] on TTE after multivariable adjustment for PAH risk factors. p-Aminohippuric Acid 215-218 endothelin 1 Homo sapiens 0-4 26752193-10 2016 Similarly, among the 65 individuals who underwent RHC, ET-1 was significantly associated with higher values of mean pulmonary artery pressure and PAH (34%, p = 0.003 and PR = 2.43, p = 0.032, respectively) in the multivariable analyses. p-Aminohippuric Acid 146-149 endothelin 1 Homo sapiens 55-59 26752193-11 2016 CONCLUSIONS: Higher levels of ET-1 are independently associated with HIV-associated PAH as hemodynamically assessed by RHC. p-Aminohippuric Acid 84-87 endothelin 1 Homo sapiens 30-34 26752193-12 2016 Our findings suggest that excessive ET-1 production in the setting of HIV infection impairs pulmonary endothelial function and contributes to the development of PAH. p-Aminohippuric Acid 161-164 endothelin 1 Homo sapiens 36-40 26669670-13 2015 Interestingly, complement genes (C1QC and C1QB) showed elevated expression in lcSSc without PAH, but were expressed at the low levels in lcSSc-PAH. p-Aminohippuric Acid 92-95 complement C1q C chain Homo sapiens 33-37 26669670-13 2015 Interestingly, complement genes (C1QC and C1QB) showed elevated expression in lcSSc without PAH, but were expressed at the low levels in lcSSc-PAH. p-Aminohippuric Acid 92-95 complement C1q B chain Homo sapiens 42-46 26669670-13 2015 Interestingly, complement genes (C1QC and C1QB) showed elevated expression in lcSSc without PAH, but were expressed at the low levels in lcSSc-PAH. p-Aminohippuric Acid 143-146 complement C1q C chain Homo sapiens 33-37 26669670-13 2015 Interestingly, complement genes (C1QC and C1QB) showed elevated expression in lcSSc without PAH, but were expressed at the low levels in lcSSc-PAH. p-Aminohippuric Acid 143-146 complement C1q B chain Homo sapiens 42-46 26669670-18 2015 CONCLUSIONS: Our study demonstrates that HLA-B*35 contributes to the dysregulated expression of selected ER stress, inflammation and proliferation related genes in lcSSc patient PBMCs, as well as healthy individuals, thus supporting a pathogenic role of HLA-B*35 in the development of PAH in SSc patients. p-Aminohippuric Acid 285-288 major histocompatibility complex, class I, B Homo sapiens 41-46 25972451-4 2015 Proteoliposomes containing the purified mNPT3 protein took up radiolabeled p-aminohippuric acid (PAH) in a Deltapsi- and Cl(-)-dependent manner. p-Aminohippuric Acid 75-95 solute carrier family 17 (sodium phosphate), member 2 Mus musculus 40-45 26888841-2 2015 METHODS: Patients (n=51) with highly suspected PAH-CTD were prospectively enrolled in our department between July 2011 and March 2014. p-Aminohippuric Acid 47-50 CTD Homo sapiens 51-54 26888841-3 2015 All patients underwent right heart catheterization (RHC) and IVUS, and were divided into 3 groups: PAH-CTD (n=25), PAH due to other reasons (n=15), and non-PAH control group (n=11). p-Aminohippuric Acid 99-102 CTD Homo sapiens 103-106 26888841-8 2015 PVMPs tended to be better in group PAH-CTD than in PAH group due to other reasons.Mortality rate was similar between the two PAH groups, while PAH with distal remodeling subtype was linked with significantly higher mortality rate than PAH with the proximal remodeling subtype (23 % vs. 0, HR=10.14, P<0.05). p-Aminohippuric Acid 35-38 CTD Homo sapiens 39-42 26888841-9 2015 CONCLUSIONS: IVUS plays an important role in the assessment of PAH-CTD patients in terms of evaluating PVPs and predicting mortality rate. p-Aminohippuric Acid 63-66 CTD Homo sapiens 67-70 26888841-10 2015 PAH patients have deteriorated PVPs, but PVMPs tended to be better in PAH-CTD than in PAH patients due to other reasons. p-Aminohippuric Acid 70-73 CTD Homo sapiens 74-77 26888841-10 2015 PAH patients have deteriorated PVPs, but PVMPs tended to be better in PAH-CTD than in PAH patients due to other reasons. p-Aminohippuric Acid 70-73 CTD Homo sapiens 74-77 26102156-4 2015 METHODS: Effective renal plasma flow (ERPF) response to angiotensin II (AngII) challenge, a marker of renal RAS activity, was measured by paraaminohippurate clearance technique in 31 OSA subjects (respiratory disturbance index, 51 +- 25 h(-1)), stratified according to nocturnal hypoxemia status (mean nocturnal SaO2, >=90% [moderate hypoxemia] or <90% [severe hypoxemia]) and 13 obese control subjects. p-Aminohippuric Acid 138-156 angiotensinogen Homo sapiens 72-77 25972451-4 2015 Proteoliposomes containing the purified mNPT3 protein took up radiolabeled p-aminohippuric acid (PAH) in a Deltapsi- and Cl(-)-dependent manner. p-Aminohippuric Acid 97-100 solute carrier family 17 (sodium phosphate), member 2 Mus musculus 40-45 25972451-5 2015 The mNPT3-mediated PAH uptake was inhibited by 4,4"-diisothiocyanostilbene-2,2"-disulfonic acid (DIDs) and Evans blue, common inhibitors of SLC17 family members. p-Aminohippuric Acid 19-22 solute carrier family 17 (sodium phosphate), member 2 Mus musculus 4-9 25770246-5 2015 However, a role of eEF2K in the pathogenesis of PAH is unknown. p-Aminohippuric Acid 48-51 eukaryotic elongation factor-2 kinase Rattus norvegicus 19-24 25919187-5 2015 Uptake of [(3)H]16alpha-OH DHEAS by BM vesicles was significantly inhibited by OAT4 substrates such as dehydroepiandrosterone sulfate, estrone-3-sulfate, and bromosulfophthalein but not by cyclosporin A, tetraethylammonium, p-aminohippuric acid, or cimetidine. p-Aminohippuric Acid 224-244 solute carrier family 22 member 11 Homo sapiens 79-83 25770246-6 2015 In the present study, we tested the hypothesis that eEF2K may be involved in the pathogenesis of PAH. p-Aminohippuric Acid 97-100 eukaryotic elongation factor-2 kinase Rattus norvegicus 52-57 25770246-12 2015 In conclusion, the present results suggest that eEF2K at least partly mediates MCT-induced PAH via stimulation of vascular structural remodeling perhaps through NADPH oxidase-1/ROS/matrix metalloproteinase-2 pathway. p-Aminohippuric Acid 91-94 eukaryotic elongation factor-2 kinase Rattus norvegicus 48-53 25770246-12 2015 In conclusion, the present results suggest that eEF2K at least partly mediates MCT-induced PAH via stimulation of vascular structural remodeling perhaps through NADPH oxidase-1/ROS/matrix metalloproteinase-2 pathway. p-Aminohippuric Acid 91-94 NADPH oxidase 1 Rattus norvegicus 161-176 25770246-12 2015 In conclusion, the present results suggest that eEF2K at least partly mediates MCT-induced PAH via stimulation of vascular structural remodeling perhaps through NADPH oxidase-1/ROS/matrix metalloproteinase-2 pathway. p-Aminohippuric Acid 91-94 matrix metallopeptidase 2 Rattus norvegicus 181-207 25785937-3 2015 Here we investigated whether a cyclooxygenase-2 (COX-2) inhibitor or diethylcarbamazine (DEC), that is known for its 5-lipoxygenase inhibiting and antioxidant actions, modify the development of PAH in the Sugen 5416/hypoxia (SuHx) rat model. p-Aminohippuric Acid 194-197 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 31-47 25856504-7 2015 Multivariate Cox proportional hazards model showed that elevated CXCL12alpha independently predicted (P<0.05) earlier death in PAH with a hazard ratio (95% confidence interval) of 2.25 (1.01-5.00). p-Aminohippuric Acid 130-133 C-X-C motif chemokine ligand 12 Homo sapiens 65-71 25862304-8 2015 Our data establish that membrane homeostasis is regulated by lipid composition in Arabidopsis and reveal a mechanism through which the abundance of PA, mediated by PAH activity, modulates CCT activity to govern PC content. p-Aminohippuric Acid 164-167 RNA polymerase II transcription mediator Arabidopsis thaliana 188-191 25477469-4 2015 We examined the effects of structural analogs of p-aminohippurate (PAH), melphalan, chlorambucil, and bendamustine, on OAT1-mediated [(3)H]PAH uptake and OAT3- and OAT4-mediated [(3)H]estrone sulfate (ES) uptake in stably transfected human embryonic kidney-293 cells. p-Aminohippuric Acid 49-65 solute carrier family 22 member 6 Homo sapiens 119-123 25477469-4 2015 We examined the effects of structural analogs of p-aminohippurate (PAH), melphalan, chlorambucil, and bendamustine, on OAT1-mediated [(3)H]PAH uptake and OAT3- and OAT4-mediated [(3)H]estrone sulfate (ES) uptake in stably transfected human embryonic kidney-293 cells. p-Aminohippuric Acid 67-70 solute carrier family 22 member 6 Homo sapiens 119-123 25477469-5 2015 Melphalan had no significant inhibitory effect on any OAT, whereas chlorambucil reduced OAT1-, OAT3-, and OAT4-mediated uptake of PAH or ES down to 14.6%, 16.3%, and 66.0% of control, respectively. p-Aminohippuric Acid 130-133 solute carrier family 22 member 6 Homo sapiens 88-92 25477469-4 2015 We examined the effects of structural analogs of p-aminohippurate (PAH), melphalan, chlorambucil, and bendamustine, on OAT1-mediated [(3)H]PAH uptake and OAT3- and OAT4-mediated [(3)H]estrone sulfate (ES) uptake in stably transfected human embryonic kidney-293 cells. p-Aminohippuric Acid 139-142 solute carrier family 22 member 6 Homo sapiens 119-123 25477469-5 2015 Melphalan had no significant inhibitory effect on any OAT, whereas chlorambucil reduced OAT1-, OAT3-, and OAT4-mediated uptake of PAH or ES down to 14.6%, 16.3%, and 66.0% of control, respectively. p-Aminohippuric Acid 130-133 solute carrier family 22 member 8 Homo sapiens 95-99 25883984-4 2015 The renal transport function was assessed by the uptake of para-aminohippurate mediated organic anion transporters 1 (Oat1) and 3 (Oat3), using renal cortical slices. p-Aminohippuric Acid 59-78 solute carrier family 22 member 6 Rattus norvegicus 88-129 25477469-5 2015 Melphalan had no significant inhibitory effect on any OAT, whereas chlorambucil reduced OAT1-, OAT3-, and OAT4-mediated uptake of PAH or ES down to 14.6%, 16.3%, and 66.0% of control, respectively. p-Aminohippuric Acid 130-133 solute carrier family 22 member 11 Homo sapiens 106-110 25895668-5 2015 The protein expression of phosphorylated extracellular signal-regulated kinase (p-ERK) and phosphorylated p38 mitogen-activated protein kinases (p-p38MAPK) were measured by Western blot in the lungs of PAH patients and hypoxia-induced rats. p-Aminohippuric Acid 202-205 eukaryotic translation initiation factor 2 alpha kinase 3 Homo sapiens 80-85 25895668-5 2015 The protein expression of phosphorylated extracellular signal-regulated kinase (p-ERK) and phosphorylated p38 mitogen-activated protein kinases (p-p38MAPK) were measured by Western blot in the lungs of PAH patients and hypoxia-induced rats. p-Aminohippuric Acid 202-205 mitogen-activated protein kinase 1 Homo sapiens 106-109 25883984-4 2015 The renal transport function was assessed by the uptake of para-aminohippurate mediated organic anion transporters 1 (Oat1) and 3 (Oat3), using renal cortical slices. p-Aminohippuric Acid 59-78 solute carrier family 22 member 8 Rattus norvegicus 131-135 25883984-7 2015 The baseline uptake of para-aminohippurate was not different among experimental groups and was correlated with Oat1 and 3 mRNA expressions. p-Aminohippuric Acid 23-42 solute carrier family 22 member 6 Rattus norvegicus 111-121 24825325-3 2014 In this study, the importance of SGK1 expression and activation was investigated on monocrotaline (MCT)-induced PAH, an inflammation-associated experimental model of PAH used in mice and rats. p-Aminohippuric Acid 112-115 serum/glucocorticoid regulated kinase 1 Mus musculus 33-37 26640952-6 2015 METHOD: To demonstrate interaction of ICA with human OAT1, OAT2, OAT3 and OAT4, ICA was tested on these transporters stably transfected in HEK293 cells by using p-aminohippurate (PAH), cGMP and estrone-3-sulfate (ES) as reference substrates, respectively. p-Aminohippuric Acid 179-182 solute carrier family 22 member 6 Homo sapiens 53-57 26640952-7 2015 RESULTS: Uptakes of PAH and ES in OAT1- and OAT3-transfected HEK293 cells were inhibited by ICA with half-maximal inhibition values of 0.29 +- 0.05 and 2.58 +- 0.16 microM, respectively. p-Aminohippuric Acid 20-23 solute carrier family 22 member 6 Homo sapiens 34-38 26640952-7 2015 RESULTS: Uptakes of PAH and ES in OAT1- and OAT3-transfected HEK293 cells were inhibited by ICA with half-maximal inhibition values of 0.29 +- 0.05 and 2.58 +- 0.16 microM, respectively. p-Aminohippuric Acid 20-23 solute carrier family 22 member 8 Homo sapiens 44-48 26006720-3 2015 Several genes including QDPR (encodes DHPR enzyme, the necessary cofactor for PAH activity) have been associated with the BH4. p-Aminohippuric Acid 78-81 quinoid dihydropteridine reductase Homo sapiens 24-28 26006720-3 2015 Several genes including QDPR (encodes DHPR enzyme, the necessary cofactor for PAH activity) have been associated with the BH4. p-Aminohippuric Acid 78-81 quinoid dihydropteridine reductase Homo sapiens 38-42 24825325-10 2014 Collectively, the present results demonstrated that SGK1 is important to the regulation of macrophage activation that contributes to the development of PAH; thus, SGK1 may be a potential therapeutic target for the treatment of PAH. p-Aminohippuric Acid 152-155 serum/glucocorticoid regulated kinase 1 Mus musculus 52-56 24825325-10 2014 Collectively, the present results demonstrated that SGK1 is important to the regulation of macrophage activation that contributes to the development of PAH; thus, SGK1 may be a potential therapeutic target for the treatment of PAH. p-Aminohippuric Acid 152-155 serum/glucocorticoid regulated kinase 1 Mus musculus 163-167 24825325-10 2014 Collectively, the present results demonstrated that SGK1 is important to the regulation of macrophage activation that contributes to the development of PAH; thus, SGK1 may be a potential therapeutic target for the treatment of PAH. p-Aminohippuric Acid 227-230 serum/glucocorticoid regulated kinase 1 Mus musculus 52-56 24825325-4 2014 The expression of SGK1 in the lungs of rats with MCT-induced PAH was significantly increased. p-Aminohippuric Acid 61-64 serum/glucocorticoid regulated kinase 1 Rattus norvegicus 18-22 24825325-10 2014 Collectively, the present results demonstrated that SGK1 is important to the regulation of macrophage activation that contributes to the development of PAH; thus, SGK1 may be a potential therapeutic target for the treatment of PAH. p-Aminohippuric Acid 227-230 serum/glucocorticoid regulated kinase 1 Mus musculus 163-167 24825325-5 2014 Furthermore, SGK1 knockout mice were resistant to MCT-induced PAH and showed less elevation of right ventricular systolic pressure and right ventricular hypertrophy and showed reduced pulmonary vascular remodeling in response to MCT injection. p-Aminohippuric Acid 62-65 serum/glucocorticoid regulated kinase 1 Mus musculus 13-17 24825325-6 2014 Administering the SGK1 inhibitor, EMD638683, to rats also prevented the development of MCT-induced PAH. p-Aminohippuric Acid 99-102 serum/glucocorticoid regulated kinase 1 Rattus norvegicus 18-22 24986368-5 2014 In vivo experiments using G2/PAH-Cit/SeNPs@siRNA led to significantly higher accumulation of siRNA within the tumor itself, VEGF gene silencing, and reduced angiogenesis in the tumor. p-Aminohippuric Acid 29-32 vascular endothelial growth factor A Mus musculus 124-128 25239859-7 2014 Furthermore, omeprazole, lansoprazole, and pantoprazole exhibited inhibited PAH uptake on hOAT1 in a concentration-dependent manner (IC50 = 4.32 +- 1.26, 7.58 +- 1.06, and 63.21 +- 4.74 microM, respectively). p-Aminohippuric Acid 76-79 solute carrier family 22 member 6 Homo sapiens 90-95 24185403-8 2014 The uptake of p-aminohippurate by hOAT1 and estron-3-sulfate by hOAT3 was decreased with increasing PCS concentration. p-Aminohippuric Acid 14-30 solute carrier family 22 member 6 Homo sapiens 34-39 24185403-8 2014 The uptake of p-aminohippurate by hOAT1 and estron-3-sulfate by hOAT3 was decreased with increasing PCS concentration. p-Aminohippuric Acid 14-30 solute carrier family 22 member 8 Homo sapiens 64-69 25002746-4 2014 Our objective was to evaluate the effects of 18 naturally occurring flavonoids, and some of their glycosides, on the uptake of para-aminohippuric acid (PAH) in both OAT1-expressing and OAT1-negative LLC-PK1 cells. p-Aminohippuric Acid 127-150 solute carrier family 22 member 6 Sus scrofa 165-169 25002746-4 2014 Our objective was to evaluate the effects of 18 naturally occurring flavonoids, and some of their glycosides, on the uptake of para-aminohippuric acid (PAH) in both OAT1-expressing and OAT1-negative LLC-PK1 cells. p-Aminohippuric Acid 152-155 solute carrier family 22 member 6 Sus scrofa 165-169 25002746-4 2014 Our objective was to evaluate the effects of 18 naturally occurring flavonoids, and some of their glycosides, on the uptake of para-aminohippuric acid (PAH) in both OAT1-expressing and OAT1-negative LLC-PK1 cells. p-Aminohippuric Acid 152-155 solute carrier family 22 member 6 Sus scrofa 185-189 25002746-5 2014 Most flavonoid aglycones produced substantial decreases in PAH uptake in OAT1-expressing cells. p-Aminohippuric Acid 59-62 solute carrier family 22 member 6 Homo sapiens 73-77 25002746-6 2014 Among the flavonoids screened, fisetin, luteolin, morin, and quercetin exhibited the strongest effect and produced complete inhibition of OAT1-mediated PAH uptake at a concentration of 50 muM. p-Aminohippuric Acid 152-155 solute carrier family 22 member 6 Homo sapiens 138-142 25002746-6 2014 Among the flavonoids screened, fisetin, luteolin, morin, and quercetin exhibited the strongest effect and produced complete inhibition of OAT1-mediated PAH uptake at a concentration of 50 muM. p-Aminohippuric Acid 152-155 latexin Homo sapiens 188-191 25148949-10 2014 Clinical and experimental evidences suggest that IFN therapy may be a possible risk factor for PAH. p-Aminohippuric Acid 95-98 interferon alpha 1 Homo sapiens 49-52 24156273-5 2014 KLF4 expression was measured in lung tissue from patients with PAH and normal control subjects. p-Aminohippuric Acid 63-66 Kruppel like factor 4 Homo sapiens 0-4 24951776-1 2014 Intervening in angiotensin (Ang)-II type 2 receptor (AT2) signaling may have therapeutic potential for bronchopulmonary dysplasia (BPD) by attenuating lung inflammation and preventing arterial hypertension (PAH)-induced right ventricular hypertrophy (RVH). p-Aminohippuric Acid 207-210 angiotensin II receptor, type 2 Rattus norvegicus 53-56 24948054-5 2014 This paper reviews some novel, promising PAH-associated signaling pathways, such as RAAS, RhoA/ROCK, PDGF, PPAR, and TGF, focusing also on their possible interactions with well-established ones such as NO, ET-1 and prostacyclin pathways. p-Aminohippuric Acid 41-44 ras homolog family member A Homo sapiens 90-94 24948054-5 2014 This paper reviews some novel, promising PAH-associated signaling pathways, such as RAAS, RhoA/ROCK, PDGF, PPAR, and TGF, focusing also on their possible interactions with well-established ones such as NO, ET-1 and prostacyclin pathways. p-Aminohippuric Acid 41-44 peroxisome proliferator activated receptor alpha Homo sapiens 107-111 24512101-2 2014 We evaluated whether luminal delivery of the human prostacyclin synthase (hPGIS) cDNA with adeno-associated virus (AAV) vectors could attenuate PAH. p-Aminohippuric Acid 144-147 prostaglandin I2 synthase Homo sapiens 51-72 24512101-2 2014 We evaluated whether luminal delivery of the human prostacyclin synthase (hPGIS) cDNA with adeno-associated virus (AAV) vectors could attenuate PAH. p-Aminohippuric Acid 144-147 prostaglandin I2 synthase Homo sapiens 74-79 24747579-9 2014 These results suggest that adefovir and benzylpenicillin can be used as probe drugs for OAT1 and OAT3, respectively, and that PAH can be used to investigate the role of OAT1 in the urinary excretion of drugs in humans, whereas it may modulate other transport processes in the kidney. p-Aminohippuric Acid 126-129 solute carrier family 22 member 6 Homo sapiens 169-173 24530383-4 2014 CPC (100 muM) reduced the uptake of MPP(+) and metformin mediated by OCT2 in MDCK-hOCT2 cells to 60.8% and 33.6% of the control, CPC (500 muM) decreased the uptake of 6-carboxyfluorescein (6-CFL) and para-aminohippuric acid (PAH), substrates of OAT1, in MDCK-hOAT1 cells to 64.6% and 79.4% of the control. p-Aminohippuric Acid 200-223 solute carrier family 22 member 2 Rattus norvegicus 69-73 24530383-4 2014 CPC (100 muM) reduced the uptake of MPP(+) and metformin mediated by OCT2 in MDCK-hOCT2 cells to 60.8% and 33.6% of the control, CPC (500 muM) decreased the uptake of 6-carboxyfluorescein (6-CFL) and para-aminohippuric acid (PAH), substrates of OAT1, in MDCK-hOAT1 cells to 64.6% and 79.4% of the control. p-Aminohippuric Acid 225-228 solute carrier family 22 member 2 Rattus norvegicus 69-73 24156273-10 2014 Finally, KLF4 expression was reduced in lungs from patients with PAH. p-Aminohippuric Acid 65-68 Kruppel like factor 4 Homo sapiens 9-13 24156273-11 2014 In conclusion, endothelial KLF4 regulates the transcription of genes involved in key pathways implicated in PAH, and its loss exacerbates pulmonary hypertension in response to chronic hypoxia in mice. p-Aminohippuric Acid 108-111 Kruppel-like factor 4 (gut) Mus musculus 27-31 24744908-0 2014 PAH clearance after renal ischemia and reperfusion is a function of impaired expression of basolateral Oat1 and Oat3. p-Aminohippuric Acid 0-3 solute carrier family 22 member 6 Rattus norvegicus 103-107 24411335-1 2014 Our previous work showed that a charge-reversal layer-by-layer nanosystem, PEI/PAH-Cit/AuNP-CS, effectively facilitates cellular uptake of siRNA and enhances the silencing efficacy of MDR1 siRNA. p-Aminohippuric Acid 79-82 ATP binding cassette subfamily B member 1 Homo sapiens 184-188 24411335-4 2014 PEI/PAH-Cit/AuNP-CS efficaciously delivered the plasmids EGFP-N1 (encoding green fluorescent protein) and pGL3.0 (encoding luciferase) into 293T and HeLa cells, thus verifying the universality of PEI/PAH-Cit/AuNP-CS as a gene carrier. p-Aminohippuric Acid 4-7 succinate dehydrogenase complex subunit C Homo sapiens 106-110 24411335-5 2014 The results of an inverted fluorescence microscopy, flow cytometry (FCM) and western blotting methods demonstrated that PC-3 prostate cancer cells treated with EGFP-p53/PEI/PAH-Cit/AuNP-CS expressed higher levels of GFP than cells treated with EGFP-p53/PEI. p-Aminohippuric Acid 173-176 tumor protein p53 Homo sapiens 249-252 24411335-6 2014 Furthermore, PC-3 cells treated with EGFP-p53/PEI/PAH-Cit/AuNP-CS showed reduced cellular viability and increased nuclear fragmentation, consistent with elevated p53 expression. p-Aminohippuric Acid 50-53 tumor protein p53 Homo sapiens 42-45 24411335-6 2014 Furthermore, PC-3 cells treated with EGFP-p53/PEI/PAH-Cit/AuNP-CS showed reduced cellular viability and increased nuclear fragmentation, consistent with elevated p53 expression. p-Aminohippuric Acid 50-53 tumor protein p53 Homo sapiens 162-165 24411335-8 2014 Western blotting and caspase activation studies revealed that EGFP-p53/PEI/PAH-Cit/AuNP-CS complexes may induce PC-3 apoptosis via the mitochondria-mediated signaling pathway by up-regulation of Bax, down-regulation of Bcl-2, and activation of caspase-3. p-Aminohippuric Acid 75-78 tumor protein p53 Homo sapiens 67-70 24411335-8 2014 Western blotting and caspase activation studies revealed that EGFP-p53/PEI/PAH-Cit/AuNP-CS complexes may induce PC-3 apoptosis via the mitochondria-mediated signaling pathway by up-regulation of Bax, down-regulation of Bcl-2, and activation of caspase-3. p-Aminohippuric Acid 75-78 BCL2 associated X, apoptosis regulator Homo sapiens 195-198 24411335-8 2014 Western blotting and caspase activation studies revealed that EGFP-p53/PEI/PAH-Cit/AuNP-CS complexes may induce PC-3 apoptosis via the mitochondria-mediated signaling pathway by up-regulation of Bax, down-regulation of Bcl-2, and activation of caspase-3. p-Aminohippuric Acid 75-78 BCL2 apoptosis regulator Homo sapiens 219-224 24411335-8 2014 Western blotting and caspase activation studies revealed that EGFP-p53/PEI/PAH-Cit/AuNP-CS complexes may induce PC-3 apoptosis via the mitochondria-mediated signaling pathway by up-regulation of Bax, down-regulation of Bcl-2, and activation of caspase-3. p-Aminohippuric Acid 75-78 caspase 3 Homo sapiens 244-253 24744908-0 2014 PAH clearance after renal ischemia and reperfusion is a function of impaired expression of basolateral Oat1 and Oat3. p-Aminohippuric Acid 0-3 solute carrier family 22 member 8 Rattus norvegicus 112-116 24744908-6 2014 PAH extraction directly correlated with the expression of basolateral Oat1 and Oat3. p-Aminohippuric Acid 0-3 solute carrier family 22 member 6 Rattus norvegicus 70-74 24744908-6 2014 PAH extraction directly correlated with the expression of basolateral Oat1 and Oat3. p-Aminohippuric Acid 0-3 solute carrier family 22 member 8 Rattus norvegicus 79-83 24450480-5 2014 Further, to determine the effect of in vivo exposure to PAH on mRNA expression of IL-4, IFN-gamma and ACSL3 genes in a rat model. p-Aminohippuric Acid 56-59 interleukin 4 Rattus norvegicus 82-86 24446489-1 2014 Idiopathic pulmonary arterial hypertension (PAH [IPAH]) is an insidious and potentially fatal disease linked to a mutation or reduced expression of bone morphogenetic protein receptor 2 (BMPR2). p-Aminohippuric Acid 44-47 bone morphogenetic protein receptor type 2 Homo sapiens 148-185 24446489-1 2014 Idiopathic pulmonary arterial hypertension (PAH [IPAH]) is an insidious and potentially fatal disease linked to a mutation or reduced expression of bone morphogenetic protein receptor 2 (BMPR2). p-Aminohippuric Acid 44-47 bone morphogenetic protein receptor type 2 Homo sapiens 187-192 24446489-7 2014 Moreover, a 3-wk infusion of GM-CSF in mice increased hypoxia-induced PAH, in association with increased perivascular macrophages and muscularized distal arteries, whereas blockade of GM-CSF repressed these features. p-Aminohippuric Acid 70-73 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 29-35 24446489-8 2014 Thus, reduced BMPR2 can subvert a stress granule response, heighten GM-CSF mRNA translation, increase inflammatory cell recruitment, and exacerbate PAH. p-Aminohippuric Acid 148-151 bone morphogenetic protein receptor type 2 Homo sapiens 14-19 24417503-11 2014 CONCLUSION: PACE enrollees experienced lower rates of hospitalization, readmission, and PAH than similar populations. p-Aminohippuric Acid 88-91 furin, paired basic amino acid cleaving enzyme Homo sapiens 12-16 24450480-5 2014 Further, to determine the effect of in vivo exposure to PAH on mRNA expression of IL-4, IFN-gamma and ACSL3 genes in a rat model. p-Aminohippuric Acid 56-59 interferon gamma Rattus norvegicus 88-97 24450480-5 2014 Further, to determine the effect of in vivo exposure to PAH on mRNA expression of IL-4, IFN-gamma and ACSL3 genes in a rat model. p-Aminohippuric Acid 56-59 acyl-CoA synthetase long-chain family member 3 Rattus norvegicus 102-107 24450480-11 2014 Results obtained in rats showed that exposure to the benzopyrene prototype PAH resulted in a 2.6 fold (P < 0.001) increased IL-4 mRNA expression in blood. p-Aminohippuric Acid 75-78 interleukin 4 Rattus norvegicus 127-131 24450480-14 2014 Additionally, PAH administration in rodents resulted in an increased IL-4 mRNA which is supposed to partly mediate the inflammatory response noted in asthma. p-Aminohippuric Acid 14-17 interleukin 4 Homo sapiens 69-73 24158367-2 2013 The method was based on the concentration difference between arterial and jugular blood, and jugular blood flow measured by downstream dilution of p-aminohippuric acid (pAH). p-Aminohippuric Acid 147-167 phenylalanine hydroxylase Bos taurus 169-172 23591205-0 2013 BaP (PAH) air quality modelling exercise over Zaragoza (Spain) using an adapted version of WRF-CMAQ model. p-Aminohippuric Acid 5-8 prohibitin 2 Homo sapiens 0-3 23591205-1 2013 Benzo(a)pyrene (BaP) is one of the most dangerous PAH due to its high carcinogenic and mutagenic character. p-Aminohippuric Acid 50-53 prohibitin 2 Homo sapiens 16-19 24908958-6 2014 In children with PAH have been identified violations of the functional activity of the endothelium, which is reflected in increased levels of ET-1, ADMA and reducing NO. p-Aminohippuric Acid 17-20 endothelin 1 Homo sapiens 142-146 23648357-11 2013 RESULTS: The EPHX1 low activity diplotype consistently imparts greater susceptibility to bronchitis from second-hand tobacco smoke, polyclic aromatic hydrocarbons (PAH) and PM2.5. p-Aminohippuric Acid 164-167 epoxide hydrolase 1 Homo sapiens 13-18 23664435-1 2013 article regarding the serum sST2 and IL-33 levels in patients with PAH. p-Aminohippuric Acid 67-70 interleukin 33 Homo sapiens 37-42 25068070-1 2013 The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that regulates a battery of genes in response to exposure to a broad class of environmental poly aromatic hydrocarbons (PAH). p-Aminohippuric Acid 199-202 aryl hydrocarbon receptor Homo sapiens 4-29 23812633-1 2013 Stimulation of MAS oncogene receptor (MAS) or angiotensin (Ang) receptor type 2 (AT2) may be novel therapeutic options for neonatal chronic lung disease (CLD) by counterbalancing the adverse effects of the potent vasoconstrictor angiotensin II, consisting of arterial hypertension (PAH)-induced right ventricular hypertrophy (RVH) and pulmonary inflammation. p-Aminohippuric Acid 282-285 angiotensin II receptor, type 2 Rattus norvegicus 81-84 23812633-8 2013 In conclusion, stimulation of MAS or AT2 attenuates cardiopulmonary injury by reducing pulmonary inflammation and preventing PAH-induced RVH but does not affect alveolar and vascular development in neonatal rats with experimental CLD. p-Aminohippuric Acid 125-128 angiotensin II receptor, type 2 Rattus norvegicus 37-40 25068070-1 2013 The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that regulates a battery of genes in response to exposure to a broad class of environmental poly aromatic hydrocarbons (PAH). p-Aminohippuric Acid 199-202 aryl hydrocarbon receptor Homo sapiens 31-34 23867956-8 2013 The PAH-DNA adduct levels in the subgroup with GSTM1 null genotype was 2-fold higher than in individuals with GSTM1 active (7.06+-5.12 vs. 13.14+-9.81 adduct/10(8) nucleotides). p-Aminohippuric Acid 4-7 glutathione S-transferase mu 1 Homo sapiens 47-52 23416326-2 2013 We further explored the interaction between PAH-DNA adducts and placental PAHs with respect to NTD risk. p-Aminohippuric Acid 44-47 fuzzy planar cell polarity protein Homo sapiens 95-98 23867956-8 2013 The PAH-DNA adduct levels in the subgroup with GSTM1 null genotype was 2-fold higher than in individuals with GSTM1 active (7.06+-5.12 vs. 13.14+-9.81 adduct/10(8) nucleotides). p-Aminohippuric Acid 4-7 glutathione S-transferase mu 1 Homo sapiens 110-115 24618541-2 2013 BMPR2 mutation carries about a 20% lifetime risk of PAH development, but penetrance is approximately three times higher in females. p-Aminohippuric Acid 52-55 bone morphogenetic protein receptor, type II (serine/threonine kinase) Mus musculus 0-5 24618541-11 2013 These data support a causal relationship between increased 16alphaOHE and increased PAH penetrance, with the likely molecular mechanisms including suppression of BMPR2, alterations in estrogen receptor translocation, and induction of vascular injury and insulin resistance-related pathways. p-Aminohippuric Acid 84-87 bone morphogenetic protein receptor, type II (serine/threonine kinase) Mus musculus 162-167 23876149-3 2013 The clean biochemical approach revealed that proteoliposomes comprising purified NPT1 as the only protein source transport various organic anions such as urate, p-aminohippuric acid (PAH), and acetylsalicylic acid (aspirin) in a membrane potential (Deltapsi)-driven and Cl(-) -dependent manner. p-Aminohippuric Acid 161-181 solute carrier family 17 member 1 Homo sapiens 81-85 23876149-3 2013 The clean biochemical approach revealed that proteoliposomes comprising purified NPT1 as the only protein source transport various organic anions such as urate, p-aminohippuric acid (PAH), and acetylsalicylic acid (aspirin) in a membrane potential (Deltapsi)-driven and Cl(-) -dependent manner. p-Aminohippuric Acid 183-186 solute carrier family 17 member 1 Homo sapiens 81-85 23416326-4 2013 Levels of PAH-DNA adducts were lower in the NTD group (8.12 per 10(8) nucleotides) compared to controls (9.92 per 10(8) nucleotides). p-Aminohippuric Acid 10-13 fuzzy planar cell polarity protein Homo sapiens 44-47 23416326-5 2013 PAH-DNA adduct concentrations below the median was associated with a 3-fold increased NTD risk. p-Aminohippuric Acid 0-3 fuzzy planar cell polarity protein Homo sapiens 86-89 23416326-6 2013 Women with a low PAH-DNA adduct level in concert with a high placental PAH level resulted in a 10-fold elevated risk of having an NTD-complicated pregnancy. p-Aminohippuric Acid 17-20 fuzzy planar cell polarity protein Homo sapiens 130-133 23416326-6 2013 Women with a low PAH-DNA adduct level in concert with a high placental PAH level resulted in a 10-fold elevated risk of having an NTD-complicated pregnancy. p-Aminohippuric Acid 71-74 fuzzy planar cell polarity protein Homo sapiens 130-133 23529922-3 2013 The uptake of p-aminohippuric acid (PAH), a substrate for Oats, by kidney slices from rats and dogs increased at 37 C and M-III inhibited the uptake. p-Aminohippuric Acid 14-34 phenylalanine hydroxylase Rattus norvegicus 36-39 21955608-6 2013 We examined the expression of Fas ligand (FasL), an apoptosis-inducing member of the TNF cytokine family, in PAH-PASMCs. p-Aminohippuric Acid 109-112 Fas ligand Homo sapiens 30-40 21955608-6 2013 We examined the expression of Fas ligand (FasL), an apoptosis-inducing member of the TNF cytokine family, in PAH-PASMCs. p-Aminohippuric Acid 109-112 Fas ligand Homo sapiens 42-46 21955608-8 2013 RESULTS: TUNEL-positive, caspase-3, 7-active cells and fragmentation of the nucleus were detected in PAH-PASMCs treated with PGI2. p-Aminohippuric Acid 101-104 caspase 3 Homo sapiens 25-34 21955608-10 2013 PCR-array analysis revealed that PGI2 upregulated the FasL gene in PAH-PASMCs, and we measured the FasL expression by quantitative RT-PCR and Western blotting. p-Aminohippuric Acid 67-70 Fas ligand Homo sapiens 54-58 23396419-5 2013 Uptake of dioscin by rat liver slices and isolated rat hepatocytes was inhibited significantly by Oatp modulators, such as ibuprofen (Oatp1a1 inhibitor), digoxin (Oatp1a4 substrate), and glycyrrhizic acid (Oatp1b2 inhibitor), but not by TEA or p-aminohippurate. p-Aminohippuric Acid 244-260 solute carrier organic anion transporter family member 1A2 Homo sapiens 98-102 23910607-9 2013 Multivariate analysis indicated that diffusing lung capacity for CO (DLCO) <=55% (HR 4.45, 95%CI 2.24-8.83; p<0.001) and sPAP >40 mmHg (HR 18.03, 95%CI 9.01-36.06; p<0.001) were associated with an increased risk to develop PAH. p-Aminohippuric Acid 235-238 PDZK1 interacting protein 1 Homo sapiens 127-131 23313623-8 2013 In hOAT1- and hOAT3-HEK293 cells, uptake of entecavir was significantly higher compared to vector-HEK293 cells and was markedly inhibited by p-aminohippurate, benzylpenicillin, and JBP485. p-Aminohippuric Acid 141-157 solute carrier family 22 member 6 Homo sapiens 3-8 23313623-8 2013 In hOAT1- and hOAT3-HEK293 cells, uptake of entecavir was significantly higher compared to vector-HEK293 cells and was markedly inhibited by p-aminohippurate, benzylpenicillin, and JBP485. p-Aminohippuric Acid 141-157 solute carrier family 22 member 8 Homo sapiens 14-19 23255614-5 2013 In OAT1-transfected cells, GSH reduced the uptake of PAH marginally. p-Aminohippuric Acid 53-56 solute carrier family 22 member 6 Homo sapiens 3-7 23354472-0 2013 Which hydrogen atom of toluene protonates PAH molecules in (+)-mode APPI MS analysis? p-Aminohippuric Acid 42-45 amyloid beta precursor protein Homo sapiens 68-72 23255614-8 2013 The GSH precursor dipeptide, cysteinyl glycine (cysgly), and the glutamate derivative N-acetyl glutamate (NAG), inhibited uptake of PAH when present in the medium and trans-stimulated uptake of PAH from the intracellular side, indicating that they are hitherto unrecognized transported substrates of OAT1. p-Aminohippuric Acid 132-135 N-acetyl-alpha-glucosaminidase Homo sapiens 86-104 23255614-8 2013 The GSH precursor dipeptide, cysteinyl glycine (cysgly), and the glutamate derivative N-acetyl glutamate (NAG), inhibited uptake of PAH when present in the medium and trans-stimulated uptake of PAH from the intracellular side, indicating that they are hitherto unrecognized transported substrates of OAT1. p-Aminohippuric Acid 132-135 N-acetyl-alpha-glucosaminidase Homo sapiens 106-109 23255614-8 2013 The GSH precursor dipeptide, cysteinyl glycine (cysgly), and the glutamate derivative N-acetyl glutamate (NAG), inhibited uptake of PAH when present in the medium and trans-stimulated uptake of PAH from the intracellular side, indicating that they are hitherto unrecognized transported substrates of OAT1. p-Aminohippuric Acid 132-135 solute carrier family 22 member 6 Homo sapiens 300-304 23255614-8 2013 The GSH precursor dipeptide, cysteinyl glycine (cysgly), and the glutamate derivative N-acetyl glutamate (NAG), inhibited uptake of PAH when present in the medium and trans-stimulated uptake of PAH from the intracellular side, indicating that they are hitherto unrecognized transported substrates of OAT1. p-Aminohippuric Acid 194-197 N-acetyl-alpha-glucosaminidase Homo sapiens 86-104 23255614-8 2013 The GSH precursor dipeptide, cysteinyl glycine (cysgly), and the glutamate derivative N-acetyl glutamate (NAG), inhibited uptake of PAH when present in the medium and trans-stimulated uptake of PAH from the intracellular side, indicating that they are hitherto unrecognized transported substrates of OAT1. p-Aminohippuric Acid 194-197 N-acetyl-alpha-glucosaminidase Homo sapiens 106-109 23862157-5 2013 Renal cortical slices were used to determine renal transport of organic anions, which are estrone sulfate and para-aminohippurate, mediated through organic anion transporter 3-Oat3. p-Aminohippuric Acid 110-129 solute carrier family 22 member 8 Rattus norvegicus 176-180 23124027-13 2012 CONCLUSIONS: GRK2-mediated desensitization-downregulation of adrenergic and dopaminergic receptors impairs inotropic reserve in PAH-RVH. p-Aminohippuric Acid 128-131 G protein-coupled receptor kinase 2 Homo sapiens 13-17 24166669-6 2013 RESULTS: Expression of rat OAT1 (rOAT1) and rOAT3 stimulated uptake of their typical substrates, p-aminohippurate and estrone sulfate, respectively, into oocytes, and caffeic acid inhibited them dose dependently. p-Aminohippuric Acid 97-113 solute carrier family 22 member 6 Rattus norvegicus 27-31 24166669-6 2013 RESULTS: Expression of rat OAT1 (rOAT1) and rOAT3 stimulated uptake of their typical substrates, p-aminohippurate and estrone sulfate, respectively, into oocytes, and caffeic acid inhibited them dose dependently. p-Aminohippuric Acid 97-113 solute carrier family 22 member 6 Rattus norvegicus 33-38 24166669-6 2013 RESULTS: Expression of rat OAT1 (rOAT1) and rOAT3 stimulated uptake of their typical substrates, p-aminohippurate and estrone sulfate, respectively, into oocytes, and caffeic acid inhibited them dose dependently. p-Aminohippuric Acid 97-113 solute carrier family 22 member 8 Rattus norvegicus 44-49 24092343-5 2013 Large randomized placebo-controlled trials of PDE-5 inhibitors demonstrated improved exercise capacity, hemodynamics and quality of life in adult patients with PAH. p-Aminohippuric Acid 160-163 phosphodiesterase 5A Homo sapiens 46-51 22875277-7 2012 NOG, 2,4-DPD and PDCA, but not DMOG, inhibited PAH uptake by OAT1 significantly. p-Aminohippuric Acid 47-50 solute carrier family 22 member 6 Homo sapiens 61-65 21773759-6 2012 Our findings may suggest a potential link between specific genotypes in the EDNRA gene and susceptibility for PAH. p-Aminohippuric Acid 110-113 endothelin receptor type A Homo sapiens 76-81 22791346-6 2012 To our knowledge this is the first study to isolate and characterize metal tolerant HMW PAH degrading bacterial consortium which shows great potential in bioremediation of mixed contaminated soils such as MGP. p-Aminohippuric Acid 88-91 cilia and flagella associated protein 97 Homo sapiens 84-87 22728397-4 2012 JBP485 (a substrate for OAT1 and OAT3), p-aminohippurate (PAH) (a substrate for OAT1) and benzylpenicillin (PCG) (a substrate for OAT3) could decrease the uptake of acyclovir in kidney slices and in hOAT1-/hOAT3-HEK293 cells. p-Aminohippuric Acid 58-61 solute carrier family 22 member 8 Homo sapiens 206-211 22759781-8 2012 The renal clearance of p-aminohippurate (PAH, a prototypical organic anion, substrate of Oat1 and Oat3) was measured by conventional clearance techniques. p-Aminohippuric Acid 23-39 solute carrier family 22 member 6 Rattus norvegicus 89-93 22728397-4 2012 JBP485 (a substrate for OAT1 and OAT3), p-aminohippurate (PAH) (a substrate for OAT1) and benzylpenicillin (PCG) (a substrate for OAT3) could decrease the uptake of acyclovir in kidney slices and in hOAT1-/hOAT3-HEK293 cells. p-Aminohippuric Acid 40-56 solute carrier family 22 member 6 Homo sapiens 80-84 22728397-4 2012 JBP485 (a substrate for OAT1 and OAT3), p-aminohippurate (PAH) (a substrate for OAT1) and benzylpenicillin (PCG) (a substrate for OAT3) could decrease the uptake of acyclovir in kidney slices and in hOAT1-/hOAT3-HEK293 cells. p-Aminohippuric Acid 40-56 solute carrier family 22 member 8 Homo sapiens 130-134 22728397-4 2012 JBP485 (a substrate for OAT1 and OAT3), p-aminohippurate (PAH) (a substrate for OAT1) and benzylpenicillin (PCG) (a substrate for OAT3) could decrease the uptake of acyclovir in kidney slices and in hOAT1-/hOAT3-HEK293 cells. p-Aminohippuric Acid 40-56 solute carrier family 22 member 6 Homo sapiens 199-204 22728397-4 2012 JBP485 (a substrate for OAT1 and OAT3), p-aminohippurate (PAH) (a substrate for OAT1) and benzylpenicillin (PCG) (a substrate for OAT3) could decrease the uptake of acyclovir in kidney slices and in hOAT1-/hOAT3-HEK293 cells. p-Aminohippuric Acid 40-56 solute carrier family 22 member 8 Homo sapiens 206-211 22728397-4 2012 JBP485 (a substrate for OAT1 and OAT3), p-aminohippurate (PAH) (a substrate for OAT1) and benzylpenicillin (PCG) (a substrate for OAT3) could decrease the uptake of acyclovir in kidney slices and in hOAT1-/hOAT3-HEK293 cells. p-Aminohippuric Acid 58-61 solute carrier family 22 member 6 Homo sapiens 80-84 22728397-4 2012 JBP485 (a substrate for OAT1 and OAT3), p-aminohippurate (PAH) (a substrate for OAT1) and benzylpenicillin (PCG) (a substrate for OAT3) could decrease the uptake of acyclovir in kidney slices and in hOAT1-/hOAT3-HEK293 cells. p-Aminohippuric Acid 58-61 solute carrier family 22 member 6 Homo sapiens 199-204 22810270-2 2012 In the course of a Scholl reaction, one of the three-dimensional bays of the TBTQ core has been bridged by a PAH unit to generate a seven-membered ring within the merged TBTQ-(hexa-peri-hexabenzocoronene) scaffold. p-Aminohippuric Acid 109-112 hexosaminidase subunit alpha Homo sapiens 176-180 22596213-9 2012 Therefore screening patients with lcSSc for vWF may identify a group at risk of developing PAH. p-Aminohippuric Acid 91-94 von Willebrand factor Homo sapiens 44-47 22108572-3 2012 The uptake of p-aminohippurate in hOAT1-expressing oocytes and of estrone sulfate in hOAT3-expressing oocytes was strongly inhibited by kynurenic acid, and other tryptophan catabolites, kynurenine and quinolinic acid, showed moderate and no inhibition, respectively. p-Aminohippuric Acid 14-30 solute carrier family 22 member 6 Homo sapiens 34-39 22027505-7 2012 Para-aminohippuric acid (PAH) significantly reduced the intracellular accumulation of AAI in rOAT1-transfected HEK293 cells. p-Aminohippuric Acid 0-23 phenylalanine hydroxylase Homo sapiens 25-28 22027505-7 2012 Para-aminohippuric acid (PAH) significantly reduced the intracellular accumulation of AAI in rOAT1-transfected HEK293 cells. p-Aminohippuric Acid 0-23 solute carrier family 22 member 6 Rattus norvegicus 93-98 22169006-3 2012 Exposure of renal S2 cells expressing hOAT1 to LXR agonists (TO901317 and GW3965) and their endogenous ligand [22(R)-hydroxycholesterol] led to the inhibition of hOAT1-mediated [(14)C]PAH uptake. p-Aminohippuric Acid 184-187 solute carrier family 22 member 6 Homo sapiens 38-43 22273603-5 2012 p-Aminohippuric acid (PAH), a substrate of organic anion transporter (OAT) 1, benzylpenicillin (PCG), a substrate of OAT3 and JBP485, a substrate of OAT1 and OAT3, reduced the uptake of bestatin in rat kidney slices and in hOAT1- or hOAT3-HEK 293 cells. p-Aminohippuric Acid 0-20 solute carrier family 22 member 6 Rattus norvegicus 43-76 22273603-5 2012 p-Aminohippuric acid (PAH), a substrate of organic anion transporter (OAT) 1, benzylpenicillin (PCG), a substrate of OAT3 and JBP485, a substrate of OAT1 and OAT3, reduced the uptake of bestatin in rat kidney slices and in hOAT1- or hOAT3-HEK 293 cells. p-Aminohippuric Acid 0-20 psoriasis susceptibility 1 candidate 2 Rattus norvegicus 96-99 22273603-5 2012 p-Aminohippuric acid (PAH), a substrate of organic anion transporter (OAT) 1, benzylpenicillin (PCG), a substrate of OAT3 and JBP485, a substrate of OAT1 and OAT3, reduced the uptake of bestatin in rat kidney slices and in hOAT1- or hOAT3-HEK 293 cells. p-Aminohippuric Acid 0-20 solute carrier family 22 member 8 Rattus norvegicus 117-121 22273603-5 2012 p-Aminohippuric acid (PAH), a substrate of organic anion transporter (OAT) 1, benzylpenicillin (PCG), a substrate of OAT3 and JBP485, a substrate of OAT1 and OAT3, reduced the uptake of bestatin in rat kidney slices and in hOAT1- or hOAT3-HEK 293 cells. p-Aminohippuric Acid 0-20 solute carrier family 22 member 6 Rattus norvegicus 149-153 22273603-5 2012 p-Aminohippuric acid (PAH), a substrate of organic anion transporter (OAT) 1, benzylpenicillin (PCG), a substrate of OAT3 and JBP485, a substrate of OAT1 and OAT3, reduced the uptake of bestatin in rat kidney slices and in hOAT1- or hOAT3-HEK 293 cells. p-Aminohippuric Acid 0-20 solute carrier family 22 member 8 Rattus norvegicus 158-162 22273603-5 2012 p-Aminohippuric acid (PAH), a substrate of organic anion transporter (OAT) 1, benzylpenicillin (PCG), a substrate of OAT3 and JBP485, a substrate of OAT1 and OAT3, reduced the uptake of bestatin in rat kidney slices and in hOAT1- or hOAT3-HEK 293 cells. p-Aminohippuric Acid 0-20 solute carrier family 22 member 6 Homo sapiens 223-228 22273603-5 2012 p-Aminohippuric acid (PAH), a substrate of organic anion transporter (OAT) 1, benzylpenicillin (PCG), a substrate of OAT3 and JBP485, a substrate of OAT1 and OAT3, reduced the uptake of bestatin in rat kidney slices and in hOAT1- or hOAT3-HEK 293 cells. p-Aminohippuric Acid 0-20 solute carrier family 22 member 8 Homo sapiens 233-238 22273603-5 2012 p-Aminohippuric acid (PAH), a substrate of organic anion transporter (OAT) 1, benzylpenicillin (PCG), a substrate of OAT3 and JBP485, a substrate of OAT1 and OAT3, reduced the uptake of bestatin in rat kidney slices and in hOAT1- or hOAT3-HEK 293 cells. p-Aminohippuric Acid 22-25 solute carrier family 22 member 6 Rattus norvegicus 43-76 22273603-5 2012 p-Aminohippuric acid (PAH), a substrate of organic anion transporter (OAT) 1, benzylpenicillin (PCG), a substrate of OAT3 and JBP485, a substrate of OAT1 and OAT3, reduced the uptake of bestatin in rat kidney slices and in hOAT1- or hOAT3-HEK 293 cells. p-Aminohippuric Acid 22-25 solute carrier family 22 member 8 Rattus norvegicus 117-121 22273603-5 2012 p-Aminohippuric acid (PAH), a substrate of organic anion transporter (OAT) 1, benzylpenicillin (PCG), a substrate of OAT3 and JBP485, a substrate of OAT1 and OAT3, reduced the uptake of bestatin in rat kidney slices and in hOAT1- or hOAT3-HEK 293 cells. p-Aminohippuric Acid 22-25 solute carrier family 22 member 6 Rattus norvegicus 149-153 21872649-2 2011 We show that 1-NP and the referent PAH benzo(a)pyrene (BP) induce apoptosis and a lipid accumulation dependent on cytochrome P450 1A1-metabolites in mouse hepatoma cells, whereas 1-amino-pyrene had no effect. p-Aminohippuric Acid 35-38 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 114-133 22523601-5 2012 Among them, Foxm1 and Plk1 are of particular interest, since Ingenuity Pathway Analysis (IPA) using DEGs and upstream motif analysis showed that they are essential hub proteins that regulate the expression of downstream proteins associated with PAH. p-Aminohippuric Acid 245-248 forkhead box M1 Homo sapiens 12-17 22523601-5 2012 Among them, Foxm1 and Plk1 are of particular interest, since Ingenuity Pathway Analysis (IPA) using DEGs and upstream motif analysis showed that they are essential hub proteins that regulate the expression of downstream proteins associated with PAH. p-Aminohippuric Acid 245-248 polo like kinase 1 Homo sapiens 22-26 21562997-5 2011 CD4 counts were significantly lower in the PAH group. p-Aminohippuric Acid 43-46 CD4 molecule Homo sapiens 0-3 21697239-5 2011 In response to ANG II infusions, PAH clearance (C(PAH)) decreased from 1.39 +- 0.27 to 0.98 +- 0.22 ml min(-1) g(-1) (P < 0.05) and glomerular filtration rate (GFR) was reduced from 0.50 +- 0.09 to 0.32 +- 0.06 ml min(-1) g(-1) (P < 0.05) in NCX1(+/-) mice. p-Aminohippuric Acid 33-36 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 15-21 21697239-5 2011 In response to ANG II infusions, PAH clearance (C(PAH)) decreased from 1.39 +- 0.27 to 0.98 +- 0.22 ml min(-1) g(-1) (P < 0.05) and glomerular filtration rate (GFR) was reduced from 0.50 +- 0.09 to 0.32 +- 0.06 ml min(-1) g(-1) (P < 0.05) in NCX1(+/-) mice. p-Aminohippuric Acid 50-53 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 15-21 21256954-12 2011 In conclusion, quercetin appears to have two faces, a flavonoid-like one and a PAH-like one which supports Ahr-mediated effects while kaempferol acts "just like a flavonoid". p-Aminohippuric Acid 79-82 aryl hydrocarbon receptor Homo sapiens 107-110 21879948-5 2011 Whatever the site, the finest PM (UF and F) induced the mRNA expression of CYP1A1, a biomarker of polyaromatic hydrocarbons (PAH) exposure, NQO-1 and heme HO-1, two antioxidant responsive element-driven genes; and two effect biomarkers, GM-CSF, a proinflammatory cytokine and amphiregulin (AR), a growth factor. p-Aminohippuric Acid 125-128 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 75-81 21676866-5 2011 The SAP30 Sin3 interaction domain (SID) binds to PAH3 via a tripartite structural motif, including a C-terminal helix that targets the canonical PAH hydrophobic cleft while two other helices and an N-terminal extension target a discrete surface formed largely by the PAH3 alpha2, alpha3, and alpha3" helices. p-Aminohippuric Acid 49-52 Sin3A associated protein 30 Homo sapiens 4-9 22140628-10 2011 The other was a set of opposite alterations that suggested an effort to modulate the PAH, e.g., up-regulation of the VIP and NOS3 genes. p-Aminohippuric Acid 85-88 vasoactive intestinal polypeptide Mus musculus 117-120 22140628-10 2011 The other was a set of opposite alterations that suggested an effort to modulate the PAH, e.g., up-regulation of the VIP and NOS3 genes. p-Aminohippuric Acid 85-88 nitric oxide synthase 3, endothelial cell Mus musculus 125-129 21486221-1 2011 The aryl hydrocarbon receptor (AhR) is a ligand activated basic helix-loop-helix transcription factor that binds to environmental poly aromatic hydrocarbons (PAH) and mediates their toxic and carcinogenic responses. p-Aminohippuric Acid 158-161 aryl hydrocarbon receptor Homo sapiens 31-34 21486221-2 2011 There is ample documentation for the role of AhR in PAH-induced carcinogenicity. p-Aminohippuric Acid 52-55 aryl hydrocarbon receptor Homo sapiens 45-48 21700537-8 2011 CONCLUSION: NT-pro BNP may be a useful biological marker for assessing the severity of SSc as it has a role in detecting the extent of skin fibrosis, the severity of PAH and the degree of restricted pulmonary involvement in SSc patients. p-Aminohippuric Acid 166-169 natriuretic peptide B Homo sapiens 19-22 21471108-14 2011 Therefore, c-kit may represent a potential target for innovative PAH therapy. p-Aminohippuric Acid 65-68 KIT proto-oncogene, receptor tyrosine kinase Homo sapiens 11-16 21561794-4 2011 Results demonstrated that diazepam, triazolam, amitriptyline, mianserin, malathion, fenitrothion, chlorpyrifosmethyl, and probenecid significantly inhibited representative substrates of hOAT1 and para-aminohippuric acid uptake by hOAT1. p-Aminohippuric Acid 196-219 solute carrier family 22 member 6 Homo sapiens 186-191 21561794-4 2011 Results demonstrated that diazepam, triazolam, amitriptyline, mianserin, malathion, fenitrothion, chlorpyrifosmethyl, and probenecid significantly inhibited representative substrates of hOAT1 and para-aminohippuric acid uptake by hOAT1. p-Aminohippuric Acid 196-219 solute carrier family 22 member 6 Homo sapiens 230-235 21244849-9 2011 Quercetin-3"-O-sulfate strongly inhibited OAT1-mediated p-aminohippuric acid uptake with an IC(50) of 1.22muM. p-Aminohippuric Acid 56-76 solute carrier family 22 member 6 Homo sapiens 42-46 20400267-4 2010 Polycylic aromatic hydrocarbons (PAH) are environmental toxicants that can be metabolized by two phase I enzymes, cytochrome P450 1A1 and 1B1. p-Aminohippuric Acid 33-36 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 114-141 21697612-3 2011 Injection of hOAT1 and hOAT3 cRNA into oocytes stimulated uptake of typical substrates of hOAT1 and hOAT3 (p-aminohippurate and estrone sulfate, respectively); among the three compounds tested, caffeic acid most strongly inhibited these transporters. p-Aminohippuric Acid 107-123 solute carrier family 22 member 6 Homo sapiens 13-18 21697612-3 2011 Injection of hOAT1 and hOAT3 cRNA into oocytes stimulated uptake of typical substrates of hOAT1 and hOAT3 (p-aminohippurate and estrone sulfate, respectively); among the three compounds tested, caffeic acid most strongly inhibited these transporters. p-Aminohippuric Acid 107-123 solute carrier family 22 member 8 Homo sapiens 23-28 21697612-3 2011 Injection of hOAT1 and hOAT3 cRNA into oocytes stimulated uptake of typical substrates of hOAT1 and hOAT3 (p-aminohippurate and estrone sulfate, respectively); among the three compounds tested, caffeic acid most strongly inhibited these transporters. p-Aminohippuric Acid 107-123 solute carrier family 22 member 6 Homo sapiens 90-95 21697612-3 2011 Injection of hOAT1 and hOAT3 cRNA into oocytes stimulated uptake of typical substrates of hOAT1 and hOAT3 (p-aminohippurate and estrone sulfate, respectively); among the three compounds tested, caffeic acid most strongly inhibited these transporters. p-Aminohippuric Acid 107-123 solute carrier family 22 member 8 Homo sapiens 100-105 32272545-2 2011 NPT4 variants carrying SNP V257F, G279R, or P378L exhibited reduced transport of [14C]para-aminohippurate, [3H]bumetanide, [3H]estrone sulfate, and [14C]urate, when each variant clone was expressed in the plasma membrane of oocytes. p-Aminohippuric Acid 86-105 solute carrier family 17 member 3 Homo sapiens 0-4 21282933-2 2011 NPT4 variants carrying SNP V257F, G279R, or P378L exhibited reduced transport of [(14)C]para-aminohippurate, [(3)H]bumetanide, [(3)H]estrone sulfate, and [(14)C]urate, when each variant clone was expressed in the plasma membrane of oocytes. p-Aminohippuric Acid 87-107 solute carrier family 17 member 3 Homo sapiens 0-4 22194859-12 2011 In addition we demonstrate C3d deposition in IPAH patients suggesting that complement activation plays a role in the development of PAH in humans. p-Aminohippuric Acid 46-49 endogenous retrovirus group K member 13 Homo sapiens 27-30 20869263-11 2010 CONCLUSIONS: FKN levels significantly correlate with preoperative hypoxemia and PAH, suggesting that FKN may be up-regulated during hypoxemia. p-Aminohippuric Acid 80-83 C-X3-C motif chemokine ligand 1 Homo sapiens 13-16 20869263-11 2010 CONCLUSIONS: FKN levels significantly correlate with preoperative hypoxemia and PAH, suggesting that FKN may be up-regulated during hypoxemia. p-Aminohippuric Acid 80-83 C-X3-C motif chemokine ligand 1 Homo sapiens 101-104 20188205-4 2010 This indicates a possible role for an increase in mitogenic ERK activity in addition to decreased proapoptotic Smad signaling in the MCT model of PAH. p-Aminohippuric Acid 146-149 Eph receptor B1 Rattus norvegicus 60-63 20566650-3 2010 Here, we show that proteoliposomes containing purified SLC17A1 transport various organic anions such as p-aminohippuric acid and acetylsalicylic acid (aspirin) in an inside positive membrane potential (Deltapsi)-dependent manner. p-Aminohippuric Acid 104-124 solute carrier family 17 member 1 Homo sapiens 55-62 20231332-1 2010 The aryl hydrocarbon receptor (AhR) is traditionally defined as a transcription factor activated by exogenous polyaromatic and halogenated aromatic hydrocarbon (PAH/HAH) ligands. p-Aminohippuric Acid 161-164 aryl hydrocarbon receptor 1a Danio rerio 4-29 20231332-1 2010 The aryl hydrocarbon receptor (AhR) is traditionally defined as a transcription factor activated by exogenous polyaromatic and halogenated aromatic hydrocarbon (PAH/HAH) ligands. p-Aminohippuric Acid 161-164 aryl hydrocarbon receptor 1a Danio rerio 31-34 20460822-3 2010 The apparent 50% inhibitory concentration (IC(50)) of aminopterin for p-aminohippurate uptake by hOAT1 was lower than that of methotrexate (methotrexate: 998 microM, aminopterin: 160 microM). p-Aminohippuric Acid 70-86 solute carrier family 22 member 6 Homo sapiens 97-102 19915082-7 2010 Perfluorohexanoate (C6), C7, and C8 inhibited Oat1-mediated p-aminohippurate transport, with C7 being the strongest inhibitor. p-Aminohippuric Acid 60-76 solute carrier family 22 member 6 Rattus norvegicus 46-50 20198579-2 2010 We evaluated the effect of NQO1 genetic variation on PAH-DNA adducts in esophageal squamous cell carcinoma (ESCC) in northeast Iran. p-Aminohippuric Acid 53-56 NAD(P)H quinone dehydrogenase 1 Homo sapiens 27-31 19533102-3 2009 The lower protein levels of Oat1 and Oat3 in basolateral membranes explain the lower uptake capacity for p-aminohippurate (in vitro assays) and the diminution of the systemic clearance of this organic anion (in vivo studies) observed in treated rats. p-Aminohippuric Acid 105-121 solute carrier family 22 member 6 Rattus norvegicus 28-32 20877132-4 2010 The apparent 50% inhibitory concentrations of lumiracoxib were estimated to be 3.3 microM and 1.9 microM for uptake of p-aminohippurate by hOAT1 and of estrone sulfate by hOAT3, respectively. p-Aminohippuric Acid 119-135 solute carrier family 22 member 6 Homo sapiens 139-144 19801450-1 2009 Peroxisome proliferator-activated receptor (PPAR)-gamma is reduced in pulmonary arteries (PAs) of patients with PA hypertension (PAH), and we reported that deletion of PPARgamma in smooth muscle cells (SMCs) of transgenic mice results in PAH. p-Aminohippuric Acid 129-132 peroxisome proliferator activated receptor gamma Homo sapiens 0-55 19801450-1 2009 Peroxisome proliferator-activated receptor (PPAR)-gamma is reduced in pulmonary arteries (PAs) of patients with PA hypertension (PAH), and we reported that deletion of PPARgamma in smooth muscle cells (SMCs) of transgenic mice results in PAH. p-Aminohippuric Acid 129-132 peroxisome proliferator activated receptor gamma Homo sapiens 168-177 19801450-1 2009 Peroxisome proliferator-activated receptor (PPAR)-gamma is reduced in pulmonary arteries (PAs) of patients with PA hypertension (PAH), and we reported that deletion of PPARgamma in smooth muscle cells (SMCs) of transgenic mice results in PAH. p-Aminohippuric Acid 238-241 peroxisome proliferator activated receptor gamma Homo sapiens 168-177 19801450-4 2009 The Tie2 PPARgamma(-/-) mice developed spontaneous PAH in RA with increased RVSP, RVH, and muscularized PAs vs. wild type (WT); both genotypes exhibited a similar degree of PAH following chronic hypoxia, but Tie2 PPARgamma(-/-) mice had more residual PAH compared with WT mice after Rec-RA. p-Aminohippuric Acid 51-54 TEK receptor tyrosine kinase Mus musculus 4-8 19801450-4 2009 The Tie2 PPARgamma(-/-) mice developed spontaneous PAH in RA with increased RVSP, RVH, and muscularized PAs vs. wild type (WT); both genotypes exhibited a similar degree of PAH following chronic hypoxia, but Tie2 PPARgamma(-/-) mice had more residual PAH compared with WT mice after Rec-RA. p-Aminohippuric Acid 51-54 peroxisome proliferator activated receptor gamma Mus musculus 9-18 19801450-6 2009 Inhibition of PDGF-Rbeta signaling with imatinib, however, was sufficient to reverse the PAH observed in the Tie2 PPARgamma(-/-) mice. p-Aminohippuric Acid 89-92 platelet derived growth factor receptor, beta polypeptide Mus musculus 14-24 19801450-6 2009 Inhibition of PDGF-Rbeta signaling with imatinib, however, was sufficient to reverse the PAH observed in the Tie2 PPARgamma(-/-) mice. p-Aminohippuric Acid 89-92 TEK receptor tyrosine kinase Mus musculus 109-113 19801450-7 2009 Thus the disruption of PPARgamma signaling in EC is sufficient to cause mild PAH and to impair recovery from CH-induced PAH. p-Aminohippuric Acid 77-80 peroxisome proliferator activated receptor gamma Mus musculus 23-32 19801450-7 2009 Thus the disruption of PPARgamma signaling in EC is sufficient to cause mild PAH and to impair recovery from CH-induced PAH. p-Aminohippuric Acid 120-123 peroxisome proliferator activated receptor gamma Mus musculus 23-32 19801450-8 2009 Inhibition of heightened PDGF-Rbeta signaling is sufficient to reverse PAH in this genetic model. p-Aminohippuric Acid 71-74 platelet derived growth factor receptor, beta polypeptide Mus musculus 25-35 19533102-3 2009 The lower protein levels of Oat1 and Oat3 in basolateral membranes explain the lower uptake capacity for p-aminohippurate (in vitro assays) and the diminution of the systemic clearance of this organic anion (in vivo studies) observed in treated rats. p-Aminohippuric Acid 105-121 solute carrier family 22 member 8 Rattus norvegicus 37-41 19643159-5 2009 AA potently inhibited the uptake of characteristic substrates, p-aminohippurate for hOAT1 and estrone sulfate for hOAT3 and hOAT4. p-Aminohippuric Acid 63-79 solute carrier family 22 member 6 Homo sapiens 84-89 19643159-5 2009 AA potently inhibited the uptake of characteristic substrates, p-aminohippurate for hOAT1 and estrone sulfate for hOAT3 and hOAT4. p-Aminohippuric Acid 63-79 solute carrier family 22 member 8 Homo sapiens 114-119 19394312-7 2009 SMF was a competitive inhibitor of p-aminohippurate uptake by hOAT1 and estrone sulfate uptake by hOAT3 with K(i) values of 225 microM and 1.5mM, respectively. p-Aminohippuric Acid 35-51 solute carrier family 22 member 6 Homo sapiens 62-67 19116370-5 2009 The contribution of rOat3 to the efflux of [(3)H]p-aminohippuric acid ([(3)H]PAH), [(3)H]benzylpenicillin ([(3)H]PCG), and [(14)C]6-mercaptopurine ([(14)C]6-MP), substrates of rOat3, from the vitreous humor/retina to the circulating blood across the inner BRB was evaluated using the microdialysis method. p-Aminohippuric Acid 77-80 solute carrier family 22 member 8 Rattus norvegicus 20-25 19439489-6 2009 The renal secretion of YM-385461, one derivative of p-aminohippuric acid, via hOAT1/rOat1, and hepatic uptake of YM-252124 via hOCT1/rOct1 was also expected. p-Aminohippuric Acid 52-72 solute carrier family 22 member 6 Homo sapiens 78-83 19439489-6 2009 The renal secretion of YM-385461, one derivative of p-aminohippuric acid, via hOAT1/rOat1, and hepatic uptake of YM-252124 via hOCT1/rOct1 was also expected. p-Aminohippuric Acid 52-72 solute carrier family 22 member 6 Rattus norvegicus 84-89 19403644-7 2009 Moreover, the interaction among citrulline, PAH, and probenecid uptakes via rat Oat1 suggested that there are multiple functional sites on Oat1 and that the citrulline site may be distinct from the PAH and probenecid site. p-Aminohippuric Acid 44-47 solute carrier family 22 member 6 Rattus norvegicus 80-84 19577083-7 2009 In contrast, left ventricular ejection fraction and cardiac index in the PAH group (50.9% +/- 3.7%, 2.66 +/- 0.12 L x min(-1) x m(-2)) were still significantly lower than in the non-PAH group (65.4% +/- 2.8%, 3.13 +/- 0.15 L x min(-1) x m(-2)) (P = .0038, .037). p-Aminohippuric Acid 73-76 CD59 molecule (CD59 blood group) Homo sapiens 118-124 19577083-7 2009 In contrast, left ventricular ejection fraction and cardiac index in the PAH group (50.9% +/- 3.7%, 2.66 +/- 0.12 L x min(-1) x m(-2)) were still significantly lower than in the non-PAH group (65.4% +/- 2.8%, 3.13 +/- 0.15 L x min(-1) x m(-2)) (P = .0038, .037). p-Aminohippuric Acid 73-76 CD59 molecule (CD59 blood group) Homo sapiens 227-233 19116370-9 2009 In conclusion, rOat3 is expressed at the inner BRB and involved in the vitreous humor/retina-to-blood transport of PAH, PCG, and 6-MP. p-Aminohippuric Acid 115-118 solute carrier family 22 member 8 Rattus norvegicus 15-20 19244988-1 2009 Interactions of purified Aldrich humic acid (PAHA) with the protein lysozyme (LSZ) are studied with dynamic light scattering and isothermal titration calorimetry by mixing LSZ and PAHA at various mass ratios. p-Aminohippuric Acid 45-49 lysozyme Homo sapiens 172-175 19159656-9 2009 Contrary, LPCi-extracts exerted maximum IFN-gamma suppression based either on air volume or regarding PM(0.5)-adsorbed PAH. p-Aminohippuric Acid 119-122 interferon gamma Homo sapiens 40-49 19302717-11 2009 Finally, Cytochrome P450 1A1 activity that reflects PAH bioavailability varied as a function of the season: it was maximal for the fine fraction in winter and for the ultrafine fraction in summer. p-Aminohippuric Acid 52-55 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 9-28 19178600-1 2009 Research on the molecular basis of PAH caused by BMPR-II mutations is beginning to yield novel approaches to therapy, for example, small molecule inhibitors of ALK-5. p-Aminohippuric Acid 35-38 bone morphogenetic protein receptor type 2 Homo sapiens 49-56 19178600-1 2009 Research on the molecular basis of PAH caused by BMPR-II mutations is beginning to yield novel approaches to therapy, for example, small molecule inhibitors of ALK-5. p-Aminohippuric Acid 35-38 transforming growth factor beta receptor 1 Homo sapiens 160-165 19244988-1 2009 Interactions of purified Aldrich humic acid (PAHA) with the protein lysozyme (LSZ) are studied with dynamic light scattering and isothermal titration calorimetry by mixing LSZ and PAHA at various mass ratios. p-Aminohippuric Acid 45-49 lysozyme Homo sapiens 68-76 19111004-8 2008 Because mRNA expression of OAT1, OAT3, and GS was decreased substantially, we ascribe the fall of p-aminohippurate accumulation and GS activity to alterations at the transcriptional level. p-Aminohippuric Acid 98-114 solute carrier family 22 member 6 Rattus norvegicus 27-31 19244988-1 2009 Interactions of purified Aldrich humic acid (PAHA) with the protein lysozyme (LSZ) are studied with dynamic light scattering and isothermal titration calorimetry by mixing LSZ and PAHA at various mass ratios. p-Aminohippuric Acid 45-49 lysozyme Homo sapiens 78-81 19370992-2 2009 In this work, dynamics of uptake ofp-aminohippurate (PAH) by basolateral membrane vesicles isolated from rat kidney proximal tubules was studied. p-Aminohippuric Acid 36-51 phenylalanine hydroxylase Rattus norvegicus 53-56 18930752-7 2008 PAH secretion across the monolayer consisted of the uptake of PAH across the basolateral membrane by OAT1 and OAT3 and the apical exit of PAH by a probenecid and MK571-sensitive route consistent with actions of MRP2 or MRP4. p-Aminohippuric Acid 0-3 solute carrier family 22 member 6 Homo sapiens 101-105 18930752-7 2008 PAH secretion across the monolayer consisted of the uptake of PAH across the basolateral membrane by OAT1 and OAT3 and the apical exit of PAH by a probenecid and MK571-sensitive route consistent with actions of MRP2 or MRP4. p-Aminohippuric Acid 0-3 solute carrier family 22 member 8 Homo sapiens 110-114 18930752-7 2008 PAH secretion across the monolayer consisted of the uptake of PAH across the basolateral membrane by OAT1 and OAT3 and the apical exit of PAH by a probenecid and MK571-sensitive route consistent with actions of MRP2 or MRP4. p-Aminohippuric Acid 0-3 ATP binding cassette subfamily C member 2 Homo sapiens 211-215 18930752-7 2008 PAH secretion across the monolayer consisted of the uptake of PAH across the basolateral membrane by OAT1 and OAT3 and the apical exit of PAH by a probenecid and MK571-sensitive route consistent with actions of MRP2 or MRP4. p-Aminohippuric Acid 0-3 ATP binding cassette subfamily C member 4 Homo sapiens 219-223 18930752-7 2008 PAH secretion across the monolayer consisted of the uptake of PAH across the basolateral membrane by OAT1 and OAT3 and the apical exit of PAH by a probenecid and MK571-sensitive route consistent with actions of MRP2 or MRP4. p-Aminohippuric Acid 62-65 solute carrier family 22 member 6 Homo sapiens 101-105 18930752-7 2008 PAH secretion across the monolayer consisted of the uptake of PAH across the basolateral membrane by OAT1 and OAT3 and the apical exit of PAH by a probenecid and MK571-sensitive route consistent with actions of MRP2 or MRP4. p-Aminohippuric Acid 62-65 solute carrier family 22 member 8 Homo sapiens 110-114 18930752-7 2008 PAH secretion across the monolayer consisted of the uptake of PAH across the basolateral membrane by OAT1 and OAT3 and the apical exit of PAH by a probenecid and MK571-sensitive route consistent with actions of MRP2 or MRP4. p-Aminohippuric Acid 62-65 solute carrier family 22 member 6 Homo sapiens 101-105 18930752-7 2008 PAH secretion across the monolayer consisted of the uptake of PAH across the basolateral membrane by OAT1 and OAT3 and the apical exit of PAH by a probenecid and MK571-sensitive route consistent with actions of MRP2 or MRP4. p-Aminohippuric Acid 62-65 solute carrier family 22 member 8 Homo sapiens 110-114 18922885-3 2008 Recently, we reported that cadaveric renal allografts exhibit maldistribution of organic anion transporter 1 (OAT1) in proximal tubule cells after ischemia and reperfusion, resulting in impairment of PAH clearance. p-Aminohippuric Acid 200-203 solute carrier family 22 member 6 Rattus norvegicus 81-108 18922885-3 2008 Recently, we reported that cadaveric renal allografts exhibit maldistribution of organic anion transporter 1 (OAT1) in proximal tubule cells after ischemia and reperfusion, resulting in impairment of PAH clearance. p-Aminohippuric Acid 200-203 solute carrier family 22 member 6 Rattus norvegicus 110-114 18564856-5 2008 Subsequent NMR and MS analysis enabled the rapid identification of 30 compounds, including 3-methyl-2-oxovalerate and 4-aminohippurate identified in HAF for the first time, to our knowledge. p-Aminohippuric Acid 118-134 coagulation factor XII Homo sapiens 149-152 18706336-7 2008 When the polyelectrolyte layers of (PAH/PSS)(3) were constructed on the Au film, the SPR biosensor with magnetic beads exhibited a satisfactory response to human IgG in the concentration range from 0.25 to 30.00 microg mL(-1), and the determination limit obtained is eight times lower than that obtained with (PAH/PSS)(1) layer. p-Aminohippuric Acid 36-39 PSS Homo sapiens 314-317 18706336-7 2008 When the polyelectrolyte layers of (PAH/PSS)(3) were constructed on the Au film, the SPR biosensor with magnetic beads exhibited a satisfactory response to human IgG in the concentration range from 0.25 to 30.00 microg mL(-1), and the determination limit obtained is eight times lower than that obtained with (PAH/PSS)(1) layer. p-Aminohippuric Acid 310-313 PSS Homo sapiens 40-43 19099753-12 2008 CONCLUSION: The up-regulation of CTGF gene expression may play an important role in the development of pulmonary vascular remodeling in PAH. p-Aminohippuric Acid 136-139 cellular communication network factor 2 Rattus norvegicus 33-37 18411268-5 2008 The pH dependence of hOAT10 suggests p-aminohippurate(-)/OH(-), urate(-)/OH(-), and nicotinate(-)/OH(-) exchange as possible transport modes. p-Aminohippuric Acid 37-53 solute carrier family 22 member 13 Homo sapiens 21-27 18551010-4 2008 DESIGN AND METHODS: Three hundred fifteen participants had renal plasma flow response to subpressor doses of angiotensin II (3 ng/kg/min) measured by para-aminohippuric acid clearance in high-sodium balance. p-Aminohippuric Acid 150-173 angiotensinogen Homo sapiens 109-123 18251511-12 2008 The similarity between rates of trans-dihydrodiol oxidation by the rat and human liver specific AKRs (AKR1C9 and AKR1C4) implicate these enzymes in hepatocarcinogenesis in rats observed with the fjord-region PAH. p-Aminohippuric Acid 208-211 aldo-keto reductase family 1, member C14 Rattus norvegicus 102-108 18216144-3 2008 Previous experiments in Oat1 knockout (-/-) mice revealed an almost complete loss of renal secretion of the prototypic organic anion p-aminohippurate (PAH) and a role of OAT1 in tubular secretion of furosemide (Eraly SA, Vallon V, Vaughn D, Gangoiti JA, Richter K, Nagle M, Monte JC, Rieg T, Truong DM, Long JM, Barshop BA, Kaler G, Nigam SK. p-Aminohippuric Acid 135-149 solute carrier family 22 (organic anion transporter), member 6 Mus musculus 24-28 18216144-3 2008 Previous experiments in Oat1 knockout (-/-) mice revealed an almost complete loss of renal secretion of the prototypic organic anion p-aminohippurate (PAH) and a role of OAT1 in tubular secretion of furosemide (Eraly SA, Vallon V, Vaughn D, Gangoiti JA, Richter K, Nagle M, Monte JC, Rieg T, Truong DM, Long JM, Barshop BA, Kaler G, Nigam SK. p-Aminohippuric Acid 151-154 solute carrier family 22 (organic anion transporter), member 6 Mus musculus 24-28 18361503-8 2008 After reconstitution of OCT1, OCT2, and OAT1 into proteoliposomes, similar Michaelis-Menten K m values were measured for uptake of 1-methyl-4-phenylpyridinium and p-aminohippurate (PAH (-)) by the organic cation and anion transporters, respectively, as after expression of the transporters in cells. p-Aminohippuric Acid 163-179 solute carrier family 22 member 1 Rattus norvegicus 24-28 18251511-12 2008 The similarity between rates of trans-dihydrodiol oxidation by the rat and human liver specific AKRs (AKR1C9 and AKR1C4) implicate these enzymes in hepatocarcinogenesis in rats observed with the fjord-region PAH. p-Aminohippuric Acid 208-211 aldo-keto reductase family 1 member C4 Homo sapiens 113-119 17884105-4 2007 When expressed in X. oocytes, rOscp1 mediated the high affinity transport of p-aminohippurate (PAH) with a Km value of 15.7+/-1.9 microM, and rOscp1-mediated organic solutes were exhibited in time- and Na+-independent manners. p-Aminohippuric Acid 77-93 organic solute carrier partner 1 Rattus norvegicus 30-36 18214934-3 2008 The genes metallothionein 2 (mt2), cytochrome P450 1A1 (cyp1a1), and recombination activation gene 1 (rag1) are used as endpoints that describe detoxification/metal toxicity (mt2), detoxification/PAH toxicity (cyp1a1), and acquired immune system disruption (rag1). p-Aminohippuric Acid 196-199 recombination activating 1 Danio rerio 102-106 18314648-3 2007 Enzymes involved in Policyclic Aromatic hidrocarbures (PAH) metabolism and degradation are polymorphic in humans, including glutation S-transferases (GSTs), N-acetiltransferases (NATs), sulfotransferases (SULTs)1A1 and cytochrome p450 (CYP)1B1. p-Aminohippuric Acid 55-58 glutathione S-transferase mu 1 Homo sapiens 150-154 18314648-3 2007 Enzymes involved in Policyclic Aromatic hidrocarbures (PAH) metabolism and degradation are polymorphic in humans, including glutation S-transferases (GSTs), N-acetiltransferases (NATs), sulfotransferases (SULTs)1A1 and cytochrome p450 (CYP)1B1. p-Aminohippuric Acid 55-58 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 236-243 17686950-9 2007 Oat3 deletion did not impact p-aminohippurate elimination, providing correlative evidence to studies in Oat1 knockout mice that suggest Oat1 governs tubular uptake of p-aminohippurate. p-Aminohippuric Acid 167-183 solute carrier family 22 (organic anion transporter), member 6 Mus musculus 136-140 17639024-7 2007 MPMA was a competitive inhibitor of p-aminohippurate uptake by OAT1 and estrone sulfate uptake by OAT3 with K(i) values of 14.5 microM and 1.5 microM, respectively. p-Aminohippuric Acid 36-52 solute carrier family 22 member 6 Homo sapiens 63-67 17639024-7 2007 MPMA was a competitive inhibitor of p-aminohippurate uptake by OAT1 and estrone sulfate uptake by OAT3 with K(i) values of 14.5 microM and 1.5 microM, respectively. p-Aminohippuric Acid 36-52 solute carrier family 22 member 8 Homo sapiens 98-102 17615446-2 2007 Some toxicities of PAH are considered to express via aryl hydrocarbon receptor (AhR). p-Aminohippuric Acid 19-22 aryl-hydrocarbon receptor Mus musculus 53-78 17615446-2 2007 Some toxicities of PAH are considered to express via aryl hydrocarbon receptor (AhR). p-Aminohippuric Acid 19-22 aryl-hydrocarbon receptor Mus musculus 80-83 18953184-7 2008 A direct correlation was observed between the secretory clearance of PAH and Oat1 (r(2) = 0.88) and Oat3 (r(2) = 0.83) expression in basolateral membranes. p-Aminohippuric Acid 69-72 solute carrier family 22 member 6 Rattus norvegicus 77-81 18953184-7 2008 A direct correlation was observed between the secretory clearance of PAH and Oat1 (r(2) = 0.88) and Oat3 (r(2) = 0.83) expression in basolateral membranes. p-Aminohippuric Acid 69-72 solute carrier family 22 member 8 Rattus norvegicus 100-104 17971680-12 2008 CONCLUSIONS: The decrease in PAH elimination observed in an early stage of renal ischemia-reperfusion in male Wistar rats might be explained by the sum of the lower OAT1 and OAT3 expression in renal basolateral plasma membranes plus the decrease in cRBF. p-Aminohippuric Acid 29-32 solute carrier family 22 member 6 Rattus norvegicus 165-169 17971680-12 2008 CONCLUSIONS: The decrease in PAH elimination observed in an early stage of renal ischemia-reperfusion in male Wistar rats might be explained by the sum of the lower OAT1 and OAT3 expression in renal basolateral plasma membranes plus the decrease in cRBF. p-Aminohippuric Acid 29-32 solute carrier family 22 member 8 Rattus norvegicus 174-178 17985403-1 2007 OBJECTIVE: Pulmonary arterial hypertension associated with connective tissue disease (PAH-CTD) is difficult to manage, and has a poor prognosis. p-Aminohippuric Acid 86-89 CTD Homo sapiens 90-93 17985403-3 2007 We examined the efficacy and safety of oral sildenafil in patients with PAH-CTD. p-Aminohippuric Acid 72-75 CTD Homo sapiens 76-79 17985403-5 2007 In a post-hoc subgroup analysis of 84 patients with PAH-CTD, exercise capacity, hemodynamic measures, World Health Organization functional class, and tolerability were assessed. p-Aminohippuric Acid 52-55 CTD Homo sapiens 56-59 17985403-11 2007 CONCLUSION: In patients with PAH-CTD, sildenafil improves exercise capacity, hemodynamic measures (at the 20 mg dose), and functional class after 12 weeks of treatment. p-Aminohippuric Acid 29-32 CTD Homo sapiens 33-36 17920288-3 2007 Among tested flavonoids, morin and silybin exhibited significant inhibition effects on the cellular uptake of [3H]-para-aminohippuric acid ([3H]-PAH) in MDCK-hOAT1 cells with Ki of 0.46 microM and 24 microM, respectively, while all the tested flavonoids appeared to be less interactive with hOAT3 compared to hOAT1. p-Aminohippuric Acid 145-148 solute carrier family 22 member 6 Homo sapiens 158-163 17920288-4 2007 A kinetic study suggested that morin and silybin inhibited hOAT1-mediated cellular uptake of [3H]-PAH in a competitive manner. p-Aminohippuric Acid 98-101 solute carrier family 22 member 6 Homo sapiens 59-64 17711870-3 2007 The effects of EPHX1 variants may depend upon exposures from tobacco smoke and traffic emissions that contain PAHs as well as variants in other enzymes in the PAH metabolic pathway such as glutathione S-transferase (GST) genes. p-Aminohippuric Acid 110-113 epoxide hydrolase 1 Homo sapiens 15-20 17719021-5 2007 cDNA-expressed and reconstituted Oat3 transported both GSH and p-aminohippurate (PAH) in exchange for 2-oxoglutarate (2-OG) and 2-OG and PAH in exchange for GSH, and PAH uptake was inhibited by both probenecid and furosemide, consistent with function of Oat3. p-Aminohippuric Acid 63-79 solute carrier family 22 member 8 Rattus norvegicus 33-37 17719021-5 2007 cDNA-expressed and reconstituted Oat3 transported both GSH and p-aminohippurate (PAH) in exchange for 2-oxoglutarate (2-OG) and 2-OG and PAH in exchange for GSH, and PAH uptake was inhibited by both probenecid and furosemide, consistent with function of Oat3. p-Aminohippuric Acid 81-84 solute carrier family 22 member 8 Rattus norvegicus 33-37 17719021-5 2007 cDNA-expressed and reconstituted Oat3 transported both GSH and p-aminohippurate (PAH) in exchange for 2-oxoglutarate (2-OG) and 2-OG and PAH in exchange for GSH, and PAH uptake was inhibited by both probenecid and furosemide, consistent with function of Oat3. p-Aminohippuric Acid 81-84 solute carrier family 22 member 8 Rattus norvegicus 254-258 17719021-5 2007 cDNA-expressed and reconstituted Oat3 transported both GSH and p-aminohippurate (PAH) in exchange for 2-oxoglutarate (2-OG) and 2-OG and PAH in exchange for GSH, and PAH uptake was inhibited by both probenecid and furosemide, consistent with function of Oat3. p-Aminohippuric Acid 137-140 solute carrier family 22 member 8 Rattus norvegicus 33-37 17719021-5 2007 cDNA-expressed and reconstituted Oat3 transported both GSH and p-aminohippurate (PAH) in exchange for 2-oxoglutarate (2-OG) and 2-OG and PAH in exchange for GSH, and PAH uptake was inhibited by both probenecid and furosemide, consistent with function of Oat3. p-Aminohippuric Acid 137-140 solute carrier family 22 member 8 Rattus norvegicus 33-37 17884105-4 2007 When expressed in X. oocytes, rOscp1 mediated the high affinity transport of p-aminohippurate (PAH) with a Km value of 15.7+/-1.9 microM, and rOscp1-mediated organic solutes were exhibited in time- and Na+-independent manners. p-Aminohippuric Acid 95-98 organic solute carrier partner 1 Rattus norvegicus 30-36 17585018-6 2007 Furthermore, hOAT3-mediated estrone-3-sulfate uptake could be inhibited, with a rank order of potency, by atorvastatin, rosuvastatin, simvastatin, and pravastatin, whereas hOAT1-mediated PAH uptake was only significantly inhibited by simvastatin. p-Aminohippuric Acid 187-190 solute carrier family 22 member 8 Homo sapiens 13-18 17878687-4 2007 On the basis of histological findings and of the results of genetic study we believe that PAH was a complication of NF1 in our patient and we suggest to screen patients with NF1 for the presence of PAH by means of trans-thoracic echocardiogram. p-Aminohippuric Acid 90-93 neurofibromin 1 Homo sapiens 116-119 17878687-4 2007 On the basis of histological findings and of the results of genetic study we believe that PAH was a complication of NF1 in our patient and we suggest to screen patients with NF1 for the presence of PAH by means of trans-thoracic echocardiogram. p-Aminohippuric Acid 90-93 neurofibromin 1 Homo sapiens 174-177 17878687-4 2007 On the basis of histological findings and of the results of genetic study we believe that PAH was a complication of NF1 in our patient and we suggest to screen patients with NF1 for the presence of PAH by means of trans-thoracic echocardiogram. p-Aminohippuric Acid 198-201 neurofibromin 1 Homo sapiens 116-119 17878687-4 2007 On the basis of histological findings and of the results of genetic study we believe that PAH was a complication of NF1 in our patient and we suggest to screen patients with NF1 for the presence of PAH by means of trans-thoracic echocardiogram. p-Aminohippuric Acid 198-201 neurofibromin 1 Homo sapiens 174-177 17312013-10 2007 We conclude that reperfused, transplanted kidneys exhibit maldistribution of hOAT1 in proximal tubule cells, resulting in impairment of PAH clearance. p-Aminohippuric Acid 136-139 solute carrier family 22 member 6 Homo sapiens 77-82 17446263-4 2007 When expressed in Xenopus laevis oocytes, mOscp1 mediated the high-affinity transport of p-aminohippurate (PAH) (K(m) = 18.8 +/- 4.1 microM) with Na(+) independence. p-Aminohippuric Acid 89-105 organic solute carrier partner 1 Mus musculus 42-48 17446263-4 2007 When expressed in Xenopus laevis oocytes, mOscp1 mediated the high-affinity transport of p-aminohippurate (PAH) (K(m) = 18.8 +/- 4.1 microM) with Na(+) independence. p-Aminohippuric Acid 107-110 organic solute carrier partner 1 Mus musculus 42-48 17446263-6 2007 Cyclophosphamide inhibited the mOscp1-mediated PAH uptake. p-Aminohippuric Acid 47-50 organic solute carrier partner 1 Mus musculus 31-37 17255469-2 2007 In the present study, the uptake of some organic anions was characterized in kidney slices from human intact renal cortical tissues: hOAT1 and hOAT3 substrates [p-aminohippurate (PAH) and 2,4-dichlorophenoxyacetate (2,4-D)] and hOAT3 substrates [benzylpenicillin (PCG), dehydroepiandrosterone sulfate (DHEAS), and estrone sulfate (ES)]. p-Aminohippuric Acid 161-177 solute carrier family 22 member 8 Homo sapiens 143-148 17353191-8 2007 PAH uptake by wild type hOAT1 was stimulated in the presence of chloride, whereas the R466K mutant was chloride-insensitive. p-Aminohippuric Acid 0-3 solute carrier family 22 member 6 Homo sapiens 24-29 17255469-9 2007 Taken together, it is likely that the uptake of PAH and 2,4-D is due to OAT1, and the uptake of PCG and ES and part of DHEAS uptake are due to OAT3 in human kidney slices. p-Aminohippuric Acid 48-51 solute carrier family 22 member 6 Homo sapiens 72-76 17244891-4 2007 Using a rat model of iARF, we investigated whether impairing the secretion of the organic anion PAH might be associated with downregulation of OAT1 or OAT3. p-Aminohippuric Acid 96-99 solute carrier family 22 member 6 Rattus norvegicus 143-147 17244891-4 2007 Using a rat model of iARF, we investigated whether impairing the secretion of the organic anion PAH might be associated with downregulation of OAT1 or OAT3. p-Aminohippuric Acid 96-99 solute carrier family 22 member 8 Rattus norvegicus 151-155 17244891-10 2007 Thus decreased expression of OAT1 and OAT3 is sufficient to explain the decline of PAH secretion after iARF. p-Aminohippuric Acid 83-86 solute carrier family 22 member 6 Rattus norvegicus 29-33 17244891-10 2007 Thus decreased expression of OAT1 and OAT3 is sufficient to explain the decline of PAH secretion after iARF. p-Aminohippuric Acid 83-86 solute carrier family 22 member 8 Rattus norvegicus 38-42 17409311-7 2007 Infection of NHERF-1(-/-) cells with adenovirus-green fluorescence protein-NHERF-1 resulted in significantly higher rates of uric acid transport (15.4 +/- 1.1 pmol/microg protein per 30 min) compared with null cells that were infected with control adenovirus-green fluorescence protein (7.9 +/- 0.3) and restoration of the inhibitory effect of para-aminohippurate (% inhibition 34 +/- 4%). p-Aminohippuric Acid 344-363 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 Mus musculus 13-20 17409311-7 2007 Infection of NHERF-1(-/-) cells with adenovirus-green fluorescence protein-NHERF-1 resulted in significantly higher rates of uric acid transport (15.4 +/- 1.1 pmol/microg protein per 30 min) compared with null cells that were infected with control adenovirus-green fluorescence protein (7.9 +/- 0.3) and restoration of the inhibitory effect of para-aminohippurate (% inhibition 34 +/- 4%). p-Aminohippuric Acid 344-363 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 Mus musculus 75-82 17229912-5 2007 PAH and glutarate are not taken up by HEK293-hOAT4 cells, but they trans-stimulated 6-CF and [(3)H]ES uptake, indicating an asymmetric interaction of hOAT4 with these substrates. p-Aminohippuric Acid 0-3 solute carrier family 22 member 11 Homo sapiens 150-155 17329910-5 2007 The Km value of the hOAT3-mediated transport was 847 microM, and the uptake was inhibited by probenecid, p-aminohippurate and benzylpenicillin with Ki values of 3.76, 712, and 202 microM, respectively. p-Aminohippuric Acid 105-121 solute carrier family 22 member 8 Homo sapiens 20-25 17229912-6 2007 In chloride-free medium, HEK293-hOAT4-mediated [(3)H]PAH efflux was almost abolished, whereas addition of ES restored it comparable to Ringer solution, consistent with a physiologic ES/PAH or PAH/Cl(-) exchange mode of hOAT4. p-Aminohippuric Acid 53-56 solute carrier family 22 member 11 Homo sapiens 32-37 17498396-8 2007 RESULTS: MPAG inhibited the uptake of PAH via hOAT1 and hOAT3, and calculated IC50 values were 222.6+/-26.6 microM and 41.5+/-11.5 microM, respectively. p-Aminohippuric Acid 38-41 solute carrier family 22 member 6 Homo sapiens 46-51 17706183-5 2007 RESULTS: Hex-PAH:BCDX12 complexes at mole ratios of 1:2 were stable in 10 mM (160 mM total borate concentration) sodium tetraborate buffer at pH 7.5 and at temperatures of 4 degrees C and 25 degrees C over 48 hours. p-Aminohippuric Acid 13-16 hematopoietically expressed homeobox Homo sapiens 9-12 17498396-8 2007 RESULTS: MPAG inhibited the uptake of PAH via hOAT1 and hOAT3, and calculated IC50 values were 222.6+/-26.6 microM and 41.5+/-11.5 microM, respectively. p-Aminohippuric Acid 38-41 solute carrier family 22 member 8 Homo sapiens 56-61 17498396-10 2007 MPAG strongly inhibited the uptake of PAH via both rMrp2 and hMRP2. p-Aminohippuric Acid 38-41 ATP binding cassette subfamily C member 2 Rattus norvegicus 51-56 17498396-10 2007 MPAG strongly inhibited the uptake of PAH via both rMrp2 and hMRP2. p-Aminohippuric Acid 38-41 ATP binding cassette subfamily C member 2 Homo sapiens 61-66 16478971-6 2006 The organic anions ochratoxin A, salicylate, penicillin G, p-aminohippurate, and urate inhibited mOat6-mediated accumulation to varying degrees. p-Aminohippuric Acid 59-75 solute carrier family 22 (organic anion transporter), member 20 Mus musculus 97-102 16997449-2 2006 p-Aminohippurate uptake exhibited similar kinetics as published values, was inhibited by cephaloridine, cimetidine, methotrexate, and urate, consistent with function of both organic anion transporter 1 (OAT1) and OAT3. p-Aminohippuric Acid 0-16 solute carrier family 22 member 6 Homo sapiens 174-201 16997449-2 2006 p-Aminohippurate uptake exhibited similar kinetics as published values, was inhibited by cephaloridine, cimetidine, methotrexate, and urate, consistent with function of both organic anion transporter 1 (OAT1) and OAT3. p-Aminohippuric Acid 0-16 solute carrier family 22 member 6 Homo sapiens 203-207 16997449-2 2006 p-Aminohippurate uptake exhibited similar kinetics as published values, was inhibited by cephaloridine, cimetidine, methotrexate, and urate, consistent with function of both organic anion transporter 1 (OAT1) and OAT3. p-Aminohippuric Acid 0-16 solute carrier family 22 member 8 Homo sapiens 213-217 16891617-1 2006 The aryl hydrocarbon receptor (AhR) is a ligand-activated basic-helix-loop-helix transcription factor that binds polyaromatic hydrocarbons (PAH), such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), and mediates their toxicity. p-Aminohippuric Acid 140-143 aryl-hydrocarbon receptor Mus musculus 4-29 16891617-1 2006 The aryl hydrocarbon receptor (AhR) is a ligand-activated basic-helix-loop-helix transcription factor that binds polyaromatic hydrocarbons (PAH), such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), and mediates their toxicity. p-Aminohippuric Acid 140-143 aryl-hydrocarbon receptor Mus musculus 31-34 16891617-2 2006 Binding of PAH to AhR in the cytoplasm triggers a poorly defined transformation step of the receptor into a nuclear transcription factor. p-Aminohippuric Acid 11-14 aryl-hydrocarbon receptor Mus musculus 18-21 17029827-0 2006 Benzo[a]pyrene-induced DNA damage and p53 modulation in human hepatoma HepG2 cells for the identification of potential biomarkers for PAH monitoring and risk assessment. p-Aminohippuric Acid 134-137 tumor protein p53 Homo sapiens 38-41 17048429-9 2006 In conclusion, treatment with GnRH agonist in Thai girls with true PP for 1 year can improve PAH without negative effects on BMD but a longer period of treatment needs to be studied. p-Aminohippuric Acid 93-96 gonadotropin releasing hormone 1 Homo sapiens 30-34 16597690-5 2006 Stable isomers of 1-SMP, (2-SMP and 4-SMP) competitively inhibited the uptake of characteristic substrates p-aminohippurate for hOAT1 and estrone sulfate for hOAT3. p-Aminohippuric Acid 107-123 solute carrier family 22 member 6 Homo sapiens 128-133 16960431-9 2006 A Raf-1 kinase inhibitor and an MEK1/2 inhibitor U0126 significantly attenuated zinc-induced decreases PAH accumulation in the slices. p-Aminohippuric Acid 103-106 A-Raf proto-oncogene, serine/threonine kinase Rattus norvegicus 0-7 16960431-9 2006 A Raf-1 kinase inhibitor and an MEK1/2 inhibitor U0126 significantly attenuated zinc-induced decreases PAH accumulation in the slices. p-Aminohippuric Acid 103-106 mitogen activated protein kinase kinase 1 Rattus norvegicus 32-38 16844357-12 2006 The present study demonstrates the key role of OAT1 expression in the impaired elimination of PAH after 3 days of obstructive cholestasis. p-Aminohippuric Acid 94-97 solute carrier family 22 member 6 Rattus norvegicus 47-51 16805952-7 2006 The cellular accumulation of L-valyl-ara-C was significantly reduced in the presence of uridine, p-aminohippurate, tetraethylammonium and small dipeptides, while it was not changed in the presence of L-valine and benzoic acid, suggesting that L-valyl-ara-C could interact with multiple uptake transporters, including peptide transporters, organic anion and cation transporters and nucleoside transporters, but might not interact with amino acid transporters. p-Aminohippuric Acid 97-113 ATP binding cassette subfamily C member 6 Homo sapiens 37-40 16597690-5 2006 Stable isomers of 1-SMP, (2-SMP and 4-SMP) competitively inhibited the uptake of characteristic substrates p-aminohippurate for hOAT1 and estrone sulfate for hOAT3. p-Aminohippuric Acid 107-123 solute carrier family 22 member 8 Homo sapiens 158-163 16724555-3 2006 Zalcitabine exhibited the inhibition effect on the cellular uptake of [3H]-PAH in CHO/hOAT1 cells with an IC50 value of 1.23 mM. p-Aminohippuric Acid 75-78 solute carrier family 22 member 6 Homo sapiens 86-91 16257192-5 2006 The substrate specificity of hOAT4 includes various steroid sulfates, such as beta-estradiol-3,17-disulfate, 17-beta-estradiol-3-sulfate, beta-estradiol-3-sulfate, and dehydroepiandrosterone-3-sulfate (DHEAS), but does not include p-aminohippuric acid (PAH) and tetraethylammonium (TEA). p-Aminohippuric Acid 253-256 solute carrier family 22 member 11 Homo sapiens 29-34 16497988-1 2006 Heterozygous germline mutations in the gene encoding the bone morphogenetic protein type II (BMPR-II) receptor underlie the majority (>70%) of cases of familial pulmonary arterial hypertension (FPAH), and dysfunction of BMP signaling has been implicated in other forms of PAH. p-Aminohippuric Acid 198-201 bone morphogenetic protein receptor, type II (serine/threonine kinase) Mus musculus 57-91 16257192-5 2006 The substrate specificity of hOAT4 includes various steroid sulfates, such as beta-estradiol-3,17-disulfate, 17-beta-estradiol-3-sulfate, beta-estradiol-3-sulfate, and dehydroepiandrosterone-3-sulfate (DHEAS), but does not include p-aminohippuric acid (PAH) and tetraethylammonium (TEA). p-Aminohippuric Acid 231-251 solute carrier family 22 member 11 Homo sapiens 29-34 16497988-1 2006 Heterozygous germline mutations in the gene encoding the bone morphogenetic protein type II (BMPR-II) receptor underlie the majority (>70%) of cases of familial pulmonary arterial hypertension (FPAH), and dysfunction of BMP signaling has been implicated in other forms of PAH. p-Aminohippuric Acid 198-201 bone morphogenetic protein receptor, type II (serine/threonine kinase) Mus musculus 93-100 16497988-9 2006 These findings provide the first evidence for an interaction between BMPR-II-mediated signaling and the serotonin pathway, perturbation of which may be critical to the pathogenesis of PAH. p-Aminohippuric Acid 184-187 bone morphogenetic protein receptor, type II (serine/threonine kinase) Mus musculus 69-76 16537869-12 2006 The finding that endothelial ET-B receptors are still present and functional in PAH may also be of relevance to the choice of selective vs nonselective ET receptor antagonists. p-Aminohippuric Acid 80-83 endothelin receptor type B Homo sapiens 29-33 16084535-0 2006 Effect of genetic polymorphisms of MnSOD and MPO on the relationship between PAH exposure and oxidative DNA damage. p-Aminohippuric Acid 77-80 superoxide dismutase 2 Homo sapiens 35-40 16249371-9 2006 Importantly, functional expression of Oat1, Oat3, and Oct2 transport as measured by kinetics (J(max) and K(t)) of PAH, ES, and TEA uptake was similar between adult male and female rabbits, and correlated with rbOat1, rbOat3, and rbOct2 protein expression. p-Aminohippuric Acid 114-117 solute carrier family 22 member 6 Oryctolagus cuniculus 38-42 16249371-9 2006 Importantly, functional expression of Oat1, Oat3, and Oct2 transport as measured by kinetics (J(max) and K(t)) of PAH, ES, and TEA uptake was similar between adult male and female rabbits, and correlated with rbOat1, rbOat3, and rbOct2 protein expression. p-Aminohippuric Acid 114-117 solute carrier family 22 member 2 Oryctolagus cuniculus 54-58 16084535-7 2006 We suggest that the oxidative injury caused by PAH exposure is modulated by genetic polymorphisms such as MnSOD and MPO. p-Aminohippuric Acid 47-50 superoxide dismutase 2 Homo sapiens 106-111 16084535-7 2006 We suggest that the oxidative injury caused by PAH exposure is modulated by genetic polymorphisms such as MnSOD and MPO. p-Aminohippuric Acid 47-50 myeloperoxidase Homo sapiens 116-119 16084535-0 2006 Effect of genetic polymorphisms of MnSOD and MPO on the relationship between PAH exposure and oxidative DNA damage. p-Aminohippuric Acid 77-80 myeloperoxidase Homo sapiens 45-48 16328621-7 2006 Although the experiment design does not permit mechanistic insights, our observation suggests that exposure of female fish to PAH mixtures such as creosote can impair the production of Vtg with possible health implications for embryos and larvae. p-Aminohippuric Acid 126-129 LOC100136735 Oncorhynchus mykiss 185-188 15944205-6 2005 Six tryptophan metabolites, including the bioactive substances KYNA, XA, and the serotonin metabolite 5-hydroxyindol acetate inhibited [(3)H]p-aminohippurate (PAH) or 6-carboxyfluorescein (6-CF) uptake by 50-85%, demonstrating that these compounds interact with OAT1 as well as with OAT3. p-Aminohippuric Acid 159-162 solute carrier family 22 (organic anion transporter), member 6 Mus musculus 262-266 17447359-2 2006 Out of 3424 deliveries conducted during the study period, 183 (5.3%) mothers were found to have one form of hypertensive disorders of pregnancy, 85.2% were cases of pregnancy induced hypertension (PIH),the majority (78.2%) were severe pre eclampsia and eclampsia; the remaining 14.8% had pregnancy aggravated hypertension (PAH) or chronic hypertension. p-Aminohippuric Acid 323-326 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 197-200 16325760-8 2005 The recombinant yeast expressing rOAT1 showed an increase in the uptake of p-aminohippurate (PAH) and this showed a positive correlation with rOAT1 expression level. p-Aminohippuric Acid 75-91 solute carrier family 22 member 6 Rattus norvegicus 33-38 16325760-8 2005 The recombinant yeast expressing rOAT1 showed an increase in the uptake of p-aminohippurate (PAH) and this showed a positive correlation with rOAT1 expression level. p-Aminohippuric Acid 75-91 solute carrier family 22 member 6 Rattus norvegicus 142-147 16325760-8 2005 The recombinant yeast expressing rOAT1 showed an increase in the uptake of p-aminohippurate (PAH) and this showed a positive correlation with rOAT1 expression level. p-Aminohippuric Acid 93-96 solute carrier family 22 member 6 Rattus norvegicus 33-38 16325760-8 2005 The recombinant yeast expressing rOAT1 showed an increase in the uptake of p-aminohippurate (PAH) and this showed a positive correlation with rOAT1 expression level. p-Aminohippuric Acid 93-96 solute carrier family 22 member 6 Rattus norvegicus 142-147 15944205-6 2005 Six tryptophan metabolites, including the bioactive substances KYNA, XA, and the serotonin metabolite 5-hydroxyindol acetate inhibited [(3)H]p-aminohippurate (PAH) or 6-carboxyfluorescein (6-CF) uptake by 50-85%, demonstrating that these compounds interact with OAT1 as well as with OAT3. p-Aminohippuric Acid 159-162 solute carrier family 22 (organic anion transporter), member 8 Mus musculus 283-287 15944205-8 2005 Quinolinate showed a slight but significant inhibition of [(3)H]PAH uptake by mOAT1 and no alteration of 6-CF uptake by mOAT3. p-Aminohippuric Acid 64-67 solute carrier family 22 (organic anion transporter), member 6 Mus musculus 78-83 16038872-4 2005 Inhibitory effects of xanthine- and uric acid-related compounds on the transport of p-aminohippuric acid were examined using CHO-K1 cells stably expressing hOAT1. p-Aminohippuric Acid 84-104 solute carrier family 22 member 6 Homo sapiens 156-161 15958719-5 2005 The sodium-dependent component of 2,4-D uptake coincided with the PAH-sensitive component, indicating uptake mediated by organic anion transporter subtype (Oat) 3. p-Aminohippuric Acid 66-69 solute carrier family 22 member 8 Rattus norvegicus 121-162 15958719-6 2005 Consistent with this, efflux of 2,4-D from preloaded tissue was accelerated by all Oat3 substrates tested, and 2,4-D increased the efflux of the Oat3 substrate, PAH. p-Aminohippuric Acid 161-164 solute carrier family 22 member 8 Rattus norvegicus 145-149 16006562-4 2005 When expressed in Xenopus laevis oocytes, hOSCP1 mediated the high affinity transport of p-aminohippurate (PAH) (K(m) = 35.0 +/- 7.5 microm) and tetraethylammonium (K(m) = 62.3 +/- 12.2 microm) in a sodium-independent manner. p-Aminohippuric Acid 89-105 organic solute carrier partner 1 Homo sapiens 42-48 16006562-4 2005 When expressed in Xenopus laevis oocytes, hOSCP1 mediated the high affinity transport of p-aminohippurate (PAH) (K(m) = 35.0 +/- 7.5 microm) and tetraethylammonium (K(m) = 62.3 +/- 12.2 microm) in a sodium-independent manner. p-Aminohippuric Acid 107-110 organic solute carrier partner 1 Homo sapiens 42-48 16006562-6 2005 The transport of PAH by hOSCP1 was sensitive to pH, but the tetraethylammonium was not transported at the high pH examined. p-Aminohippuric Acid 17-20 organic solute carrier partner 1 Homo sapiens 24-30 16006562-9 2005 A wide range of structurally unrelated organic compounds inhibited the hOSCP1-mediated PAH uptake. p-Aminohippuric Acid 87-90 organic solute carrier partner 1 Homo sapiens 71-77 15914676-6 2005 When expressed in Xenopus oocytes, wild-type R50-hOAT1 and the variants R50H-hOAT1 and K525I-hOAT1 all mediated the probenecid-sensitive uptake of the classic organic anion para-aminohippurate (PAH). p-Aminohippuric Acid 173-192 solute carrier family 22 member 6 Homo sapiens 49-54 15870380-7 2005 The uptake of the prototype OAT substrate PAH in hOAT1-expressing oocytes was dose dependently and potently inhibited by EA with an IC(50)of 207 nM. p-Aminohippuric Acid 42-45 solute carrier family 22 member 6 Homo sapiens 49-54 15900017-10 2005 Other inhibitors of rOatps (taurocholate and pravastatin) and rOat3 (pravastatin and p-aminohippurate) had a slight effect, but digoxin had no effect. p-Aminohippuric Acid 85-101 solute carrier family 22 member 8 Rattus norvegicus 62-67 15914676-6 2005 When expressed in Xenopus oocytes, wild-type R50-hOAT1 and the variants R50H-hOAT1 and K525I-hOAT1 all mediated the probenecid-sensitive uptake of the classic organic anion para-aminohippurate (PAH). p-Aminohippuric Acid 173-192 solute carrier family 22 member 6 Homo sapiens 77-82 15914676-6 2005 When expressed in Xenopus oocytes, wild-type R50-hOAT1 and the variants R50H-hOAT1 and K525I-hOAT1 all mediated the probenecid-sensitive uptake of the classic organic anion para-aminohippurate (PAH). p-Aminohippuric Acid 173-192 solute carrier family 22 member 6 Homo sapiens 77-82 15914676-6 2005 When expressed in Xenopus oocytes, wild-type R50-hOAT1 and the variants R50H-hOAT1 and K525I-hOAT1 all mediated the probenecid-sensitive uptake of the classic organic anion para-aminohippurate (PAH). p-Aminohippuric Acid 194-197 solute carrier family 22 member 6 Homo sapiens 49-54 15914676-6 2005 When expressed in Xenopus oocytes, wild-type R50-hOAT1 and the variants R50H-hOAT1 and K525I-hOAT1 all mediated the probenecid-sensitive uptake of the classic organic anion para-aminohippurate (PAH). p-Aminohippuric Acid 194-197 solute carrier family 22 member 6 Homo sapiens 77-82 15914676-6 2005 When expressed in Xenopus oocytes, wild-type R50-hOAT1 and the variants R50H-hOAT1 and K525I-hOAT1 all mediated the probenecid-sensitive uptake of the classic organic anion para-aminohippurate (PAH). p-Aminohippuric Acid 194-197 solute carrier family 22 member 6 Homo sapiens 77-82 15669050-8 2005 Glutamine synthetase activity in renal tissue showed a significant (P < 0.05) dose-dependent decrease 24 and 48 h after treatment in both sexes, but is was significantly (P < 0.05) greater in female rats after 48 h. p-Aminohippuric acid uptake in renal cortical slices appeared significantly (P < 0.05) decreased in both sexes at the higher dose 24 h after treatment but this was significantly (P < 0.05) greater in female rats. p-Aminohippuric Acid 224-242 glutamate-ammonia ligase Rattus norvegicus 0-20 15845886-9 2005 Moreover, we show that the pulmonary vasculature of patients with familial and idiopathic PAH are deficient in the activated form of Smad1. p-Aminohippuric Acid 90-93 SMAD family member 1 Homo sapiens 133-138 15820748-2 2005 Meanwhile, another transport protein involved in p-aminohippurate (PAH) uptake on the basolateral side of the proximal tubule cells was identified, designated organic anion transporter 3 (OAT3). p-Aminohippuric Acid 49-65 solute carrier family 22 member 8 Sus scrofa 159-186 15820748-2 2005 Meanwhile, another transport protein involved in p-aminohippurate (PAH) uptake on the basolateral side of the proximal tubule cells was identified, designated organic anion transporter 3 (OAT3). p-Aminohippuric Acid 49-65 solute carrier family 22 member 8 Sus scrofa 188-192 15820748-2 2005 Meanwhile, another transport protein involved in p-aminohippurate (PAH) uptake on the basolateral side of the proximal tubule cells was identified, designated organic anion transporter 3 (OAT3). p-Aminohippuric Acid 67-70 solute carrier family 22 member 8 Sus scrofa 159-186 15820748-2 2005 Meanwhile, another transport protein involved in p-aminohippurate (PAH) uptake on the basolateral side of the proximal tubule cells was identified, designated organic anion transporter 3 (OAT3). p-Aminohippuric Acid 67-70 solute carrier family 22 member 8 Sus scrofa 188-192 15820748-3 2005 To explore the contribution of pOAT1 to the PAH clearance in comparison to OAT3, it was the aim of this study to extend our model by cloning of the pig ortholog of OAT3. p-Aminohippuric Acid 44-47 solute carrier family 22 member 6 Sus scrofa 31-36 15820748-3 2005 To explore the contribution of pOAT1 to the PAH clearance in comparison to OAT3, it was the aim of this study to extend our model by cloning of the pig ortholog of OAT3. p-Aminohippuric Acid 44-47 solute carrier family 22 member 8 Sus scrofa 164-168 15644426-5 2005 In contrast, steviol showed significant, dose-dependent inhibition of PAH and ES uptake in hOAT1- or hOAT3-expressing oocytes, respectively. p-Aminohippuric Acid 70-73 solute carrier family 22 member 6 Homo sapiens 91-96 15644426-6 2005 The IC(50) of steviol for hOAT1-mediated PAH transport was 11.1 microM compared with 62.6 microM for hOAT3-mediated ES uptake. p-Aminohippuric Acid 41-44 solute carrier family 22 member 6 Homo sapiens 26-31 15748710-6 2005 Basolateral PAH transport showed a higher correlation with the protein level of rOAT1 (r(2)=0.80) than rOAT3 (r(2)=0.34), whereas basolateral TEA transport showed a strong correlation with rOCT2 protein (r(2)=0.91). p-Aminohippuric Acid 12-15 solute carrier family 22 member 6 Rattus norvegicus 80-85 16086552-1 2005 The role of phenylalanine 4-monooxygenase (PAH) in the S-oxidation of S-carboxymethyl-L-cysteine (SCMC) in the rat has now been well established in rat cytosolic fractions in vitro. p-Aminohippuric Acid 43-46 phenylalanine hydroxylase Homo sapiens 12-41 16043102-6 2005 Conversely, transplantation of PAH-positive hepatocytes into PAH-deficient Pah(enu2) mice, a model of human PKU, yielded a significant decrease in serum phenylalanine (<700 muM) when liver repopulation exceeded approximately 5%. p-Aminohippuric Acid 75-78 phenylalanine hydroxylase Mus musculus 31-34 16043102-6 2005 Conversely, transplantation of PAH-positive hepatocytes into PAH-deficient Pah(enu2) mice, a model of human PKU, yielded a significant decrease in serum phenylalanine (<700 muM) when liver repopulation exceeded approximately 5%. p-Aminohippuric Acid 75-78 phenylalanine hydroxylase Mus musculus 61-64 15919055-10 2005 These results suggest that the inhibitory effects of PAHs on osteoclastogenesis are direct and likely involve interaction of the RANKL and PAH signaling pathways. p-Aminohippuric Acid 53-56 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 129-134 16240585-9 2005 The present study demonstrates a correlation between PAH exposure, as assessed by urinary 1-OHP, and the induction of HO-1 expression. p-Aminohippuric Acid 53-56 heme oxygenase 1 Homo sapiens 118-122 15878738-3 2005 The objective of this work was to study, in rats with experimental CRF (5/6 nephrectomy), the expression of the organic anion transporter 1 (OAT1) and organic anion transporter 3 (OAT3) and their contribution to the pharmacokinetics and renal excretion of p-aminohippurate (PAH). p-Aminohippuric Acid 274-277 solute carrier family 22 member 6 Rattus norvegicus 112-139 15878738-3 2005 The objective of this work was to study, in rats with experimental CRF (5/6 nephrectomy), the expression of the organic anion transporter 1 (OAT1) and organic anion transporter 3 (OAT3) and their contribution to the pharmacokinetics and renal excretion of p-aminohippurate (PAH). p-Aminohippuric Acid 274-277 solute carrier family 22 member 6 Rattus norvegicus 141-145 15878738-3 2005 The objective of this work was to study, in rats with experimental CRF (5/6 nephrectomy), the expression of the organic anion transporter 1 (OAT1) and organic anion transporter 3 (OAT3) and their contribution to the pharmacokinetics and renal excretion of p-aminohippurate (PAH). p-Aminohippuric Acid 274-277 solute carrier family 22 member 8 Rattus norvegicus 151-178 15878738-3 2005 The objective of this work was to study, in rats with experimental CRF (5/6 nephrectomy), the expression of the organic anion transporter 1 (OAT1) and organic anion transporter 3 (OAT3) and their contribution to the pharmacokinetics and renal excretion of p-aminohippurate (PAH). p-Aminohippuric Acid 274-277 solute carrier family 22 member 8 Rattus norvegicus 180-184 15846470-6 2005 The uptake of PAH and PCG was inhibited in a dose-dependent manner by unlabeled PCG (IC(50) = 47.3 mM) and PAH (IC(50) = 512 microM), respectively, suggesting that different transporters are responsible for their uptake. p-Aminohippuric Acid 14-17 psoriasis susceptibility 1 candidate 2 Rattus norvegicus 80-83 15846470-6 2005 The uptake of PAH and PCG was inhibited in a dose-dependent manner by unlabeled PCG (IC(50) = 47.3 mM) and PAH (IC(50) = 512 microM), respectively, suggesting that different transporters are responsible for their uptake. p-Aminohippuric Acid 107-110 psoriasis susceptibility 1 candidate 2 Rattus norvegicus 22-25 15846470-8 2005 Excess PAH, which could inhibit rOat1 and rOat3, completely inhibited the saturable uptake of IA, IS, and CMPF by the kidney, and by 85% for HA uptake. p-Aminohippuric Acid 7-10 solute carrier family 22 member 6 Rattus norvegicus 32-37 15846470-8 2005 Excess PAH, which could inhibit rOat1 and rOat3, completely inhibited the saturable uptake of IA, IS, and CMPF by the kidney, and by 85% for HA uptake. p-Aminohippuric Acid 7-10 solute carrier family 22 member 8 Rattus norvegicus 42-47 15777215-3 2005 Complex interactions between PAH-mediated AhR activation and ER signalling pathways have been discovered which may contribute to the developmental malformations, impact on reproductive dysfunctions and promote carcinogenic dedifferentiation of tissues within the female reproductive tract. p-Aminohippuric Acid 29-32 aryl hydrocarbon receptor Homo sapiens 42-45 15801548-12 2004 The results suggest that the tubular secretion of compound A is not mediated by P-gp, but rather is mediated, at least in part, via the organic anion transporter OAT3, the renal transporter shown to be capable of transporting both the organic anion PAH and the organic cation cimetidine. p-Aminohippuric Acid 249-252 solute carrier family 22 member 8 Rattus norvegicus 162-166 15389674-8 2004 Probenecid and substrates of rOat3, such as p-aminohippurate, benzylpenicillin, and cimetidine, inhibited the uptake of 2,4-D by the isolated rat CP. p-Aminohippuric Acid 44-60 solute carrier family 22 member 8 Rattus norvegicus 29-34 15251863-2 2004 The activity of organic anion transporters OAT1 and OAT3 proved to be distinguishable because OAT1 had a high affinity for PAH (K(t) of 20 microM) and did not support estrone sulfate (ES) transport, whereas OAT3 had a high affinity for ES (K(t) of 4.5 microM) and a weak interaction with PAH (IC(50) > 1 mM). p-Aminohippuric Acid 123-126 solute carrier family 22 member 6 Oryctolagus cuniculus 43-47 15251863-2 2004 The activity of organic anion transporters OAT1 and OAT3 proved to be distinguishable because OAT1 had a high affinity for PAH (K(t) of 20 microM) and did not support estrone sulfate (ES) transport, whereas OAT3 had a high affinity for ES (K(t) of 4.5 microM) and a weak interaction with PAH (IC(50) > 1 mM). p-Aminohippuric Acid 123-126 solute carrier family 22 member 8 Oryctolagus cuniculus 52-56 15251863-2 2004 The activity of organic anion transporters OAT1 and OAT3 proved to be distinguishable because OAT1 had a high affinity for PAH (K(t) of 20 microM) and did not support estrone sulfate (ES) transport, whereas OAT3 had a high affinity for ES (K(t) of 4.5 microM) and a weak interaction with PAH (IC(50) > 1 mM). p-Aminohippuric Acid 123-126 solute carrier family 22 member 6 Oryctolagus cuniculus 94-98 15251863-2 2004 The activity of organic anion transporters OAT1 and OAT3 proved to be distinguishable because OAT1 had a high affinity for PAH (K(t) of 20 microM) and did not support estrone sulfate (ES) transport, whereas OAT3 had a high affinity for ES (K(t) of 4.5 microM) and a weak interaction with PAH (IC(50) > 1 mM). p-Aminohippuric Acid 288-291 solute carrier family 22 member 6 Oryctolagus cuniculus 43-47 15251863-2 2004 The activity of organic anion transporters OAT1 and OAT3 proved to be distinguishable because OAT1 had a high affinity for PAH (K(t) of 20 microM) and did not support estrone sulfate (ES) transport, whereas OAT3 had a high affinity for ES (K(t) of 4.5 microM) and a weak interaction with PAH (IC(50) > 1 mM). p-Aminohippuric Acid 288-291 solute carrier family 22 member 8 Oryctolagus cuniculus 52-56 15251863-2 2004 The activity of organic anion transporters OAT1 and OAT3 proved to be distinguishable because OAT1 had a high affinity for PAH (K(t) of 20 microM) and did not support estrone sulfate (ES) transport, whereas OAT3 had a high affinity for ES (K(t) of 4.5 microM) and a weak interaction with PAH (IC(50) > 1 mM). p-Aminohippuric Acid 288-291 solute carrier family 22 member 6 Oryctolagus cuniculus 94-98 15504935-0 2004 Contribution of multidrug resistance protein 2 (MRP2/ABCC2) to the renal excretion of p-aminohippurate (PAH) and identification of MRP4 (ABCC4) as a novel PAH transporter. p-Aminohippuric Acid 86-102 ATP binding cassette subfamily C member 2 Rattus norvegicus 48-52 15504935-0 2004 Contribution of multidrug resistance protein 2 (MRP2/ABCC2) to the renal excretion of p-aminohippurate (PAH) and identification of MRP4 (ABCC4) as a novel PAH transporter. p-Aminohippuric Acid 104-107 ATP binding cassette subfamily C member 2 Rattus norvegicus 48-52 15504935-3 2004 The multidrug resistance protein 2 (MRP2/ABCC2) is localized to the apical membrane and mediates ATP-dependent PAH transport, but its contribution to urinary PAH excretion is not known. p-Aminohippuric Acid 111-114 ATP binding cassette subfamily C member 2 Rattus norvegicus 36-40 15504935-3 2004 The multidrug resistance protein 2 (MRP2/ABCC2) is localized to the apical membrane and mediates ATP-dependent PAH transport, but its contribution to urinary PAH excretion is not known. p-Aminohippuric Acid 158-161 ATP binding cassette subfamily C member 2 Rattus norvegicus 36-40 15504935-5 2004 Uptake of [(14)C]PAH in membrane vesicles expressing two different MRP2 clones isolated from Sf9 and MDCKII cells exhibited a low affinity for PAH (Sf9, 5 +/- 2 mM; MDCKII, 2.1 +/- 0.6 mM). p-Aminohippuric Acid 17-20 ATP binding cassette subfamily C member 2 Rattus norvegicus 67-71 15504935-5 2004 Uptake of [(14)C]PAH in membrane vesicles expressing two different MRP2 clones isolated from Sf9 and MDCKII cells exhibited a low affinity for PAH (Sf9, 5 +/- 2 mM; MDCKII, 2.1 +/- 0.6 mM). p-Aminohippuric Acid 143-146 ATP binding cassette subfamily C member 2 Rattus norvegicus 67-71 15504935-6 2004 Human MRP4 (ABCC4), which has recently been localized to the apical membrane, expressed in Sf9 cells had a much higher affinity for PAH (K(m) = 160 +/- 50 microM). p-Aminohippuric Acid 132-135 ATP binding cassette subfamily C member 4 Homo sapiens 6-10 15504935-6 2004 Human MRP4 (ABCC4), which has recently been localized to the apical membrane, expressed in Sf9 cells had a much higher affinity for PAH (K(m) = 160 +/- 50 microM). p-Aminohippuric Acid 132-135 ATP binding cassette subfamily C member 4 Homo sapiens 12-17 15504935-7 2004 Various inhibitors of MRP2-mediated PAH transport also inhibited MRP4. p-Aminohippuric Acid 36-39 ATP binding cassette subfamily C member 2 Rattus norvegicus 22-26 15504935-7 2004 Various inhibitors of MRP2-mediated PAH transport also inhibited MRP4. p-Aminohippuric Acid 36-39 ATP binding cassette subfamily C member 4 Homo sapiens 65-69 15504935-11 2004 MRP4 is a novel PAH transporter that has higher affinity for PAH and is expressed more highly in kidney than MRP2, and may therefore be more important in renal PAH excretion. p-Aminohippuric Acid 16-19 ATP binding cassette subfamily C member 4 Homo sapiens 0-4 15504935-11 2004 MRP4 is a novel PAH transporter that has higher affinity for PAH and is expressed more highly in kidney than MRP2, and may therefore be more important in renal PAH excretion. p-Aminohippuric Acid 16-19 ATP binding cassette subfamily C member 2 Rattus norvegicus 109-113 15504935-11 2004 MRP4 is a novel PAH transporter that has higher affinity for PAH and is expressed more highly in kidney than MRP2, and may therefore be more important in renal PAH excretion. p-Aminohippuric Acid 61-64 ATP binding cassette subfamily C member 4 Homo sapiens 0-4 15504935-11 2004 MRP4 is a novel PAH transporter that has higher affinity for PAH and is expressed more highly in kidney than MRP2, and may therefore be more important in renal PAH excretion. p-Aminohippuric Acid 61-64 ATP binding cassette subfamily C member 2 Rattus norvegicus 109-113 15801548-4 2004 The tubular secretion of compound A was saturable at high plasma levels (> 26 microM), and was inhibited significantly, although modestly (about twofold) by relatively high plasma concentrations of the organic anion PAH (160 microM) and the cation cimetidine (about 400 microM), but not by the P-gp inhibitor quinidine (about 50 microM). p-Aminohippuric Acid 219-222 phosphoglycolate phosphatase Rattus norvegicus 297-301 15287094-7 2004 The overall percentage of COX-2 positive glands was 7.5%, distributed as 0.2% positive glands in normal prostate tissue, 25.7% in postatrophic hyperplasia (PAH), and 11.9% in simple atrophy (SA). p-Aminohippuric Acid 156-159 prostaglandin-endoperoxide synthase 2 Homo sapiens 26-31 15480914-6 2004 When DTPH uses phenylalanine as a substrate, regulatory control (end product inhibition, decreased PAH activity following phosphorylation, catecholamine inhibition) is observed that is not seen when the enzyme uses tryptophan as a substrate. p-Aminohippuric Acid 99-102 Henna Drosophila melanogaster 5-9 15316568-1 2004 Resveratrol inhibits PAH bioactivation through reduced expression of the CYP1A1 and CYP1B1 genes in human bronchial epithelial cells. p-Aminohippuric Acid 21-24 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 73-79 15316568-1 2004 Resveratrol inhibits PAH bioactivation through reduced expression of the CYP1A1 and CYP1B1 genes in human bronchial epithelial cells. p-Aminohippuric Acid 21-24 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 84-90 15553238-6 2004 Furthermore, the transport activity of E1S, DHEAS, MTX, and PAH normalized by the expression level of BCRP protein was almost the same for the wild type, V12M, Q141K, A149P, R163K, Q166E, and P269S BCRP. p-Aminohippuric Acid 60-63 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 198-202 14979872-2 2004 mOAT1-mediated transport of organic anion PAH ( p -aminohippurate) in HeLa cells was inhibited by the cysteine-modifying reagent PCMBS (p-chloromercuribenzenesulphonate). p-Aminohippuric Acid 42-45 solute carrier family 22 (organic anion transporter), member 6 Mus musculus 0-5 14979872-2 2004 mOAT1-mediated transport of organic anion PAH ( p -aminohippurate) in HeLa cells was inhibited by the cysteine-modifying reagent PCMBS (p-chloromercuribenzenesulphonate). p-Aminohippuric Acid 48-65 solute carrier family 22 (organic anion transporter), member 6 Mus musculus 0-5 15075193-3 2004 We recently generated an organic anion transporter 3- (Oat3)-null mouse, which exhibited loss of PAH, estrone sulfate, and taurocholate transport in kidney and of fluorescein (FL) transport in choroid plexus. p-Aminohippuric Acid 97-100 solute carrier family 22 (organic anion transporter), member 8 Mus musculus 25-59 15075193-5 2004 Mediated transport of PAH and FL was essentially abolished in tissue from Oat3-null mice. p-Aminohippuric Acid 22-25 solute carrier family 22 (organic anion transporter), member 8 Mus musculus 74-78 15075193-7 2004 For PAH, FL, and estrone sulfate, all Oat3-mediated transport was Na dependent. p-Aminohippuric Acid 4-7 solute carrier family 22 (organic anion transporter), member 8 Mus musculus 38-42 15006513-0 2004 PAH Growth from the pyrolysis of CPD, indene and naphthalene mixture. p-Aminohippuric Acid 0-3 carboxypeptidase D Homo sapiens 33-36 15100168-4 2004 When expressed in Xenopus laevis oocytes, mOat3 mediated the uptake of p-aminohippuric acid and estron sulfate (ES). p-Aminohippuric Acid 71-91 solute carrier family 22 (organic anion transporter), member 8 Mus musculus 42-47 14722319-4 2004 Folate and benzylpenicillin (PCG) inhibited the uptake by 30 to 40% and 40 to 50% of the total saturable uptake of MTX by kidney slices, respectively, whereas the effect of p-aminohippurate (PAH) was minimal at the concentration selective for rOat1. p-Aminohippuric Acid 191-194 psoriasis susceptibility 1 candidate 2 Rattus norvegicus 29-32 15039295-10 2004 Further functional comparisons of hOAT1-1 and hOAT1-2 in fluorescein uptake studies exhibited almost identical affinities for fluorescein with Michaelis constants of 11.6 +/- 3.7 microM (hOAT1-1) and 11.9 +/- 6.4 microM (hOAT1-2), and similar sensitivities to inhibition by p-aminohippurate [IC(50): 16 microM (hOAT1-1), 10 microM (hOAT1-2)], urate [IC(50): 440 microM (hOAT1-1), 385 microM (hOAT1-2)], and furosemide (IC(50): 14 microM (hOAT1-1), 20 microM (hOAT1-2)], implying functional equivalence. p-Aminohippuric Acid 274-290 solute carrier family 22 member 6 Homo sapiens 34-39 15039295-10 2004 Further functional comparisons of hOAT1-1 and hOAT1-2 in fluorescein uptake studies exhibited almost identical affinities for fluorescein with Michaelis constants of 11.6 +/- 3.7 microM (hOAT1-1) and 11.9 +/- 6.4 microM (hOAT1-2), and similar sensitivities to inhibition by p-aminohippurate [IC(50): 16 microM (hOAT1-1), 10 microM (hOAT1-2)], urate [IC(50): 440 microM (hOAT1-1), 385 microM (hOAT1-2)], and furosemide (IC(50): 14 microM (hOAT1-1), 20 microM (hOAT1-2)], implying functional equivalence. p-Aminohippuric Acid 274-290 solute carrier family 22 member 6 Homo sapiens 46-51 15039295-10 2004 Further functional comparisons of hOAT1-1 and hOAT1-2 in fluorescein uptake studies exhibited almost identical affinities for fluorescein with Michaelis constants of 11.6 +/- 3.7 microM (hOAT1-1) and 11.9 +/- 6.4 microM (hOAT1-2), and similar sensitivities to inhibition by p-aminohippurate [IC(50): 16 microM (hOAT1-1), 10 microM (hOAT1-2)], urate [IC(50): 440 microM (hOAT1-1), 385 microM (hOAT1-2)], and furosemide (IC(50): 14 microM (hOAT1-1), 20 microM (hOAT1-2)], implying functional equivalence. p-Aminohippuric Acid 274-290 solute carrier family 22 member 6 Homo sapiens 46-51 15039295-10 2004 Further functional comparisons of hOAT1-1 and hOAT1-2 in fluorescein uptake studies exhibited almost identical affinities for fluorescein with Michaelis constants of 11.6 +/- 3.7 microM (hOAT1-1) and 11.9 +/- 6.4 microM (hOAT1-2), and similar sensitivities to inhibition by p-aminohippurate [IC(50): 16 microM (hOAT1-1), 10 microM (hOAT1-2)], urate [IC(50): 440 microM (hOAT1-1), 385 microM (hOAT1-2)], and furosemide (IC(50): 14 microM (hOAT1-1), 20 microM (hOAT1-2)], implying functional equivalence. p-Aminohippuric Acid 274-290 solute carrier family 22 member 6 Homo sapiens 46-51 15039295-10 2004 Further functional comparisons of hOAT1-1 and hOAT1-2 in fluorescein uptake studies exhibited almost identical affinities for fluorescein with Michaelis constants of 11.6 +/- 3.7 microM (hOAT1-1) and 11.9 +/- 6.4 microM (hOAT1-2), and similar sensitivities to inhibition by p-aminohippurate [IC(50): 16 microM (hOAT1-1), 10 microM (hOAT1-2)], urate [IC(50): 440 microM (hOAT1-1), 385 microM (hOAT1-2)], and furosemide (IC(50): 14 microM (hOAT1-1), 20 microM (hOAT1-2)], implying functional equivalence. p-Aminohippuric Acid 274-290 solute carrier family 22 member 6 Homo sapiens 46-51 15039295-10 2004 Further functional comparisons of hOAT1-1 and hOAT1-2 in fluorescein uptake studies exhibited almost identical affinities for fluorescein with Michaelis constants of 11.6 +/- 3.7 microM (hOAT1-1) and 11.9 +/- 6.4 microM (hOAT1-2), and similar sensitivities to inhibition by p-aminohippurate [IC(50): 16 microM (hOAT1-1), 10 microM (hOAT1-2)], urate [IC(50): 440 microM (hOAT1-1), 385 microM (hOAT1-2)], and furosemide (IC(50): 14 microM (hOAT1-1), 20 microM (hOAT1-2)], implying functional equivalence. p-Aminohippuric Acid 274-290 solute carrier family 22 member 6 Homo sapiens 46-51 15039295-10 2004 Further functional comparisons of hOAT1-1 and hOAT1-2 in fluorescein uptake studies exhibited almost identical affinities for fluorescein with Michaelis constants of 11.6 +/- 3.7 microM (hOAT1-1) and 11.9 +/- 6.4 microM (hOAT1-2), and similar sensitivities to inhibition by p-aminohippurate [IC(50): 16 microM (hOAT1-1), 10 microM (hOAT1-2)], urate [IC(50): 440 microM (hOAT1-1), 385 microM (hOAT1-2)], and furosemide (IC(50): 14 microM (hOAT1-1), 20 microM (hOAT1-2)], implying functional equivalence. p-Aminohippuric Acid 274-290 solute carrier family 22 member 6 Homo sapiens 46-51 15039295-10 2004 Further functional comparisons of hOAT1-1 and hOAT1-2 in fluorescein uptake studies exhibited almost identical affinities for fluorescein with Michaelis constants of 11.6 +/- 3.7 microM (hOAT1-1) and 11.9 +/- 6.4 microM (hOAT1-2), and similar sensitivities to inhibition by p-aminohippurate [IC(50): 16 microM (hOAT1-1), 10 microM (hOAT1-2)], urate [IC(50): 440 microM (hOAT1-1), 385 microM (hOAT1-2)], and furosemide (IC(50): 14 microM (hOAT1-1), 20 microM (hOAT1-2)], implying functional equivalence. p-Aminohippuric Acid 274-290 solute carrier family 22 member 6 Homo sapiens 46-51 15039295-10 2004 Further functional comparisons of hOAT1-1 and hOAT1-2 in fluorescein uptake studies exhibited almost identical affinities for fluorescein with Michaelis constants of 11.6 +/- 3.7 microM (hOAT1-1) and 11.9 +/- 6.4 microM (hOAT1-2), and similar sensitivities to inhibition by p-aminohippurate [IC(50): 16 microM (hOAT1-1), 10 microM (hOAT1-2)], urate [IC(50): 440 microM (hOAT1-1), 385 microM (hOAT1-2)], and furosemide (IC(50): 14 microM (hOAT1-1), 20 microM (hOAT1-2)], implying functional equivalence. p-Aminohippuric Acid 274-290 solute carrier family 22 member 6 Homo sapiens 46-51 15039295-10 2004 Further functional comparisons of hOAT1-1 and hOAT1-2 in fluorescein uptake studies exhibited almost identical affinities for fluorescein with Michaelis constants of 11.6 +/- 3.7 microM (hOAT1-1) and 11.9 +/- 6.4 microM (hOAT1-2), and similar sensitivities to inhibition by p-aminohippurate [IC(50): 16 microM (hOAT1-1), 10 microM (hOAT1-2)], urate [IC(50): 440 microM (hOAT1-1), 385 microM (hOAT1-2)], and furosemide (IC(50): 14 microM (hOAT1-1), 20 microM (hOAT1-2)], implying functional equivalence. p-Aminohippuric Acid 274-290 solute carrier family 22 member 6 Homo sapiens 46-51 15534862-11 2004 The similarities between the DNA adduct patterns produced by DBC and MeDBC in V79MZh1A1 and V79MZh1A2 cells suggest that biotransformation mediated via CYP1A1 and CYP1A2 might depend on a PAH-type pathway involving the aromatic ring system. p-Aminohippuric Acid 188-191 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 152-158 15037815-6 2004 In addition, both the uptake and efflux of [14C]p-aminohippuric acid (PAH) and [14C]GA via S2 OAT4 were significantly trans-stimulated by unlabeled GA or PAH. p-Aminohippuric Acid 70-73 solute carrier family 22 member 11 Homo sapiens 94-98 15037815-6 2004 In addition, both the uptake and efflux of [14C]p-aminohippuric acid (PAH) and [14C]GA via S2 OAT4 were significantly trans-stimulated by unlabeled GA or PAH. p-Aminohippuric Acid 154-157 solute carrier family 22 member 11 Homo sapiens 94-98 13129851-4 2004 [3H]PAH and 3H-labeled estrone sulfate ([3H]ES) were used as specific substrates for rbOAT1 and rbOAT3, respectively. p-Aminohippuric Acid 4-7 solute carrier family 22 member 8 Oryctolagus cuniculus 96-102 15534862-11 2004 The similarities between the DNA adduct patterns produced by DBC and MeDBC in V79MZh1A1 and V79MZh1A2 cells suggest that biotransformation mediated via CYP1A1 and CYP1A2 might depend on a PAH-type pathway involving the aromatic ring system. p-Aminohippuric Acid 188-191 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 163-169 12954363-4 2003 p-Aminohippuric acid, a substrate of rat organic anion transporter1 (rOat1), and cimetidine, a substrate of rOat3, reduced the urinary excretion of phenolsulfonphthalein. p-Aminohippuric Acid 0-20 solute carrier family 22 member 6 Rattus norvegicus 41-67 14613719-11 2003 These data suggest that there is an inverse relationship between liver metabolism and BM toxicity resulting from limitations on the delivery of PAH to CYP1B1 present in BM, where only very low constitutive levels are needed. p-Aminohippuric Acid 144-147 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 151-157 14601136-3 2003 Our specific hypothesis was that phenylalanine hydroxylase (PAH) expressed in bone marrow would lower blood phenylalanine levels in hyperphenylalaninemic Pah(enu2) mice, a model of human phenylketonuria (PKU). p-Aminohippuric Acid 154-157 phenylalanine hydroxylase Mus musculus 33-58 14734677-3 2004 It has been proposed that OAT1 is indirectly involved in PAH uptake via the Na(+) dicarboxylate cotransporter. p-Aminohippuric Acid 57-60 solute carrier family 22 member 6 Rattus norvegicus 26-30 14729155-13 2003 Basolateral PAH transport (presumably OAT1 activity) appears to be down-regulated by activation of protein kinase C (PKC) and up-regulated via mitogen-activated protein kinase (MAPK) through phospholipase A(2) (PLA(2)), prostaglandin E(2) (PGE(2)), cyclic AMP, and protein kinase A (PKA) activation. p-Aminohippuric Acid 12-15 solute carrier family 22 member 6 Oryctolagus cuniculus 38-42 14729155-13 2003 Basolateral PAH transport (presumably OAT1 activity) appears to be down-regulated by activation of protein kinase C (PKC) and up-regulated via mitogen-activated protein kinase (MAPK) through phospholipase A(2) (PLA(2)), prostaglandin E(2) (PGE(2)), cyclic AMP, and protein kinase A (PKA) activation. p-Aminohippuric Acid 12-15 phospholipase A2 Oryctolagus cuniculus 191-209 14729155-13 2003 Basolateral PAH transport (presumably OAT1 activity) appears to be down-regulated by activation of protein kinase C (PKC) and up-regulated via mitogen-activated protein kinase (MAPK) through phospholipase A(2) (PLA(2)), prostaglandin E(2) (PGE(2)), cyclic AMP, and protein kinase A (PKA) activation. p-Aminohippuric Acid 12-15 phospholipase A2 Oryctolagus cuniculus 211-217 12954363-4 2003 p-Aminohippuric acid, a substrate of rat organic anion transporter1 (rOat1), and cimetidine, a substrate of rOat3, reduced the urinary excretion of phenolsulfonphthalein. p-Aminohippuric Acid 0-20 solute carrier family 22 member 6 Rattus norvegicus 69-74 12684544-0 2003 Contribution of organic anion transporter 3 (Slc22a8) to the elimination of p-aminohippuric acid and benzylpenicillin across the blood-brain barrier. p-Aminohippuric Acid 76-96 solute carrier family 22 member 8 Rattus norvegicus 16-43 12874449-3 2003 Stimulation of PKC with sn-1,2-dioctanoylglycerol resulted in strong inhibition of p-aminohippurate transport mediated by the cloned human organic anion transporter 1 (hOAT1) expressed in Xenopus oocytes and HEK293 cells, as well as hOAT1 internalization in both expression systems. p-Aminohippuric Acid 83-99 solute carrier family 22 member 6 Homo sapiens 139-166 12874449-3 2003 Stimulation of PKC with sn-1,2-dioctanoylglycerol resulted in strong inhibition of p-aminohippurate transport mediated by the cloned human organic anion transporter 1 (hOAT1) expressed in Xenopus oocytes and HEK293 cells, as well as hOAT1 internalization in both expression systems. p-Aminohippuric Acid 83-99 solute carrier family 22 member 6 Homo sapiens 168-173 12874449-3 2003 Stimulation of PKC with sn-1,2-dioctanoylglycerol resulted in strong inhibition of p-aminohippurate transport mediated by the cloned human organic anion transporter 1 (hOAT1) expressed in Xenopus oocytes and HEK293 cells, as well as hOAT1 internalization in both expression systems. p-Aminohippuric Acid 83-99 solute carrier family 22 member 6 Homo sapiens 233-238 12874449-5 2003 It was independent of the conserved canonical PKC consensus sites in hOAT1, however, and was unaffected by agents that destabilize actin filaments or microtubules, which altered baseline hOAT1-mediated p-aminohippurate uptake activity in oocytes. p-Aminohippuric Acid 204-218 solute carrier family 22 member 6 Homo sapiens 187-192 12684544-0 2003 Contribution of organic anion transporter 3 (Slc22a8) to the elimination of p-aminohippuric acid and benzylpenicillin across the blood-brain barrier. p-Aminohippuric Acid 76-96 solute carrier family 22 member 8 Rattus norvegicus 45-52 12684544-5 2003 The contribution of rOat3 to the efflux of para-aminohippuric acid (PAH) and benzylpenicillin (PCG), substrates of rOat3, from the cerebrum into the blood circulation across the BBB was evaluated using the Brain Efflux Index method. p-Aminohippuric Acid 43-66 solute carrier family 22 member 8 Rattus norvegicus 20-25 12684544-5 2003 The contribution of rOat3 to the efflux of para-aminohippuric acid (PAH) and benzylpenicillin (PCG), substrates of rOat3, from the cerebrum into the blood circulation across the BBB was evaluated using the Brain Efflux Index method. p-Aminohippuric Acid 43-66 phenylalanine hydroxylase Rattus norvegicus 68-71 12660303-1 2003 Our previous kinetic analyses have shown that rat organic anion transporter 1 (rOat1; Slc22a6) and rOat3 (Slc22a8) are responsible for the renal uptake of p-aminohippurate and pravastatin, respectively. p-Aminohippuric Acid 155-171 solute carrier family 22 member 6 Rattus norvegicus 50-77 12877347-0 2003 RT-PCR-based evidence for the in vivo stimulation of renal tubularp-aminohippurate (PAH) transport by triiodothyronine (T3) or dexamethasone (DEXA) in kidney tissue of immature and adult rats. p-Aminohippuric Acid 67-82 phenylalanine hydroxylase Rattus norvegicus 84-87 12660303-1 2003 Our previous kinetic analyses have shown that rat organic anion transporter 1 (rOat1; Slc22a6) and rOat3 (Slc22a8) are responsible for the renal uptake of p-aminohippurate and pravastatin, respectively. p-Aminohippuric Acid 155-171 solute carrier family 22 member 6 Rattus norvegicus 79-84 12660303-1 2003 Our previous kinetic analyses have shown that rat organic anion transporter 1 (rOat1; Slc22a6) and rOat3 (Slc22a8) are responsible for the renal uptake of p-aminohippurate and pravastatin, respectively. p-Aminohippuric Acid 155-171 solute carrier family 22 member 6 Rattus norvegicus 86-93 12660303-1 2003 Our previous kinetic analyses have shown that rat organic anion transporter 1 (rOat1; Slc22a6) and rOat3 (Slc22a8) are responsible for the renal uptake of p-aminohippurate and pravastatin, respectively. p-Aminohippuric Acid 155-171 solute carrier family 22 member 8 Rattus norvegicus 99-104 12660303-1 2003 Our previous kinetic analyses have shown that rat organic anion transporter 1 (rOat1; Slc22a6) and rOat3 (Slc22a8) are responsible for the renal uptake of p-aminohippurate and pravastatin, respectively. p-Aminohippuric Acid 155-171 solute carrier family 22 member 8 Rattus norvegicus 106-113 12605306-8 2003 OAT1 translocated, e.g., anti-inflammatory drugs, antiviral drugs, beta-lactam antibiotics, loop diuretics, ochratoxin A, and p-aminohippurate. p-Aminohippuric Acid 126-142 solute carrier family 22 member 6 Homo sapiens 0-4 12711831-1 2003 The purpose of the present study was to examine in rats the effects of acute bile duct ligation on the expression of the organic anion transporter 1 in the kidney and the consequences of these effects on the systemic clearance of organic anions, particularly on P-aminohippurate (PAH) clearance, since it has been viewed as the prototypic organic anion. p-Aminohippuric Acid 262-278 solute carrier family 22 member 6 Rattus norvegicus 121-148 12711831-1 2003 The purpose of the present study was to examine in rats the effects of acute bile duct ligation on the expression of the organic anion transporter 1 in the kidney and the consequences of these effects on the systemic clearance of organic anions, particularly on P-aminohippurate (PAH) clearance, since it has been viewed as the prototypic organic anion. p-Aminohippuric Acid 280-283 solute carrier family 22 member 6 Rattus norvegicus 121-148 12606766-6 2003 The cytotoxic effects were fully reversed by probenecid (an OAT1 inhibitor) and partially reversed by p-aminohippurate (an OAT1 substrate). p-Aminohippuric Acid 102-118 solute carrier family 22 member 6 Homo sapiens 123-127 12538807-3 2003 Since the OAT1 transporter has the characteristics of para-aminokippurate (PAH) transport that closely correlate to the native RPT, we examined the interaction of DCVC, CTFC, and the nontoxic benzothiazolylcysteine (BTC) with PAH transport mediated by human OAT1 and rabbit Oat1 expressed in Chinese hamster ovary and COS7 heterologous expression systems, respectively. p-Aminohippuric Acid 75-78 solute carrier family 22 member 6 Homo sapiens 10-14 12538807-3 2003 Since the OAT1 transporter has the characteristics of para-aminokippurate (PAH) transport that closely correlate to the native RPT, we examined the interaction of DCVC, CTFC, and the nontoxic benzothiazolylcysteine (BTC) with PAH transport mediated by human OAT1 and rabbit Oat1 expressed in Chinese hamster ovary and COS7 heterologous expression systems, respectively. p-Aminohippuric Acid 226-229 solute carrier family 22 member 6 Homo sapiens 10-14 12538807-4 2003 Although the K(m) values for PAH uptake by hOAT1 and rbOat1 (8.9 +/- 3.6 and 20.7 +/- 8 microM, respectively) were 5- to 10-fold less than the K(m) for peritubular PAH transport into rabbit RPT, the IC(50) values for DCVC, CTFC, and BTC inhibition of PAH uptake mediated by either hOAT1 or rbOat1 were similar between these two transporters and to the IC(50) values for these conjugates measured in rabbit RPT. p-Aminohippuric Acid 29-32 solute carrier family 22 member 6 Homo sapiens 43-48 12538807-4 2003 Although the K(m) values for PAH uptake by hOAT1 and rbOat1 (8.9 +/- 3.6 and 20.7 +/- 8 microM, respectively) were 5- to 10-fold less than the K(m) for peritubular PAH transport into rabbit RPT, the IC(50) values for DCVC, CTFC, and BTC inhibition of PAH uptake mediated by either hOAT1 or rbOat1 were similar between these two transporters and to the IC(50) values for these conjugates measured in rabbit RPT. p-Aminohippuric Acid 29-32 solute carrier family 22 member 6 Homo sapiens 281-286 12538807-4 2003 Although the K(m) values for PAH uptake by hOAT1 and rbOat1 (8.9 +/- 3.6 and 20.7 +/- 8 microM, respectively) were 5- to 10-fold less than the K(m) for peritubular PAH transport into rabbit RPT, the IC(50) values for DCVC, CTFC, and BTC inhibition of PAH uptake mediated by either hOAT1 or rbOat1 were similar between these two transporters and to the IC(50) values for these conjugates measured in rabbit RPT. p-Aminohippuric Acid 164-167 solute carrier family 22 member 6 Homo sapiens 43-48 12538807-4 2003 Although the K(m) values for PAH uptake by hOAT1 and rbOat1 (8.9 +/- 3.6 and 20.7 +/- 8 microM, respectively) were 5- to 10-fold less than the K(m) for peritubular PAH transport into rabbit RPT, the IC(50) values for DCVC, CTFC, and BTC inhibition of PAH uptake mediated by either hOAT1 or rbOat1 were similar between these two transporters and to the IC(50) values for these conjugates measured in rabbit RPT. p-Aminohippuric Acid 164-167 solute carrier family 22 member 6 Homo sapiens 43-48 12538807-5 2003 The IC(50) for inhibition of hOAT1- and rbOat1-mediated PAH uptake by the hydrophobic conjugate BTC was more than 5-fold lower than the IC(50) values seen with DCVC and CTFC, suggesting that hydrophobicity increases the affinity of OAT1 for cysteine conjugates. p-Aminohippuric Acid 56-59 solute carrier family 22 member 6 Homo sapiens 29-34 12538807-5 2003 The IC(50) for inhibition of hOAT1- and rbOat1-mediated PAH uptake by the hydrophobic conjugate BTC was more than 5-fold lower than the IC(50) values seen with DCVC and CTFC, suggesting that hydrophobicity increases the affinity of OAT1 for cysteine conjugates. p-Aminohippuric Acid 56-59 solute carrier family 22 member 6 Oryctolagus cuniculus 30-34 14586168-7 2003 RESULTS: hOAT3-mediated efflux of glutarate (GA), can be significantly trans-stimulated by a variety of ions with high cis-inhibitory potency, including GA (282%), alpha-ketoglutarate (476%), p-aminohippurate (179%), and, most notably, urate (167%). p-Aminohippuric Acid 192-208 solute carrier family 22 member 8 Homo sapiens 9-14 12700417-0 2003 Cytochrome P4501A1 and 1A2 gene expression in the liver of 3-methylcholanthrene- and o-aminoazotoluene-treated mice: a comparison between PAH-responsive and PAH-nonresponsive strains. p-Aminohippuric Acid 138-141 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 0-26 12700417-0 2003 Cytochrome P4501A1 and 1A2 gene expression in the liver of 3-methylcholanthrene- and o-aminoazotoluene-treated mice: a comparison between PAH-responsive and PAH-nonresponsive strains. p-Aminohippuric Acid 157-160 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 0-26 12488248-5 2003 Probenecid-sensitive uptake of p-aminohippurate (PAH, an Oat1 and Oat3 substrate) and estrone sulfate (ES, an Oat3 substrate) in rat Oat3-expressing oocytes was significantly trans-stimulated by preloading the oocytes with the dicarboxylate glutarate (GA). p-Aminohippuric Acid 31-47 solute carrier family 22 member 6 Rattus norvegicus 57-61 12488248-5 2003 Probenecid-sensitive uptake of p-aminohippurate (PAH, an Oat1 and Oat3 substrate) and estrone sulfate (ES, an Oat3 substrate) in rat Oat3-expressing oocytes was significantly trans-stimulated by preloading the oocytes with the dicarboxylate glutarate (GA). p-Aminohippuric Acid 31-47 solute carrier family 22 member 8 Rattus norvegicus 66-70 12488248-5 2003 Probenecid-sensitive uptake of p-aminohippurate (PAH, an Oat1 and Oat3 substrate) and estrone sulfate (ES, an Oat3 substrate) in rat Oat3-expressing oocytes was significantly trans-stimulated by preloading the oocytes with the dicarboxylate glutarate (GA). p-Aminohippuric Acid 49-52 solute carrier family 22 member 6 Rattus norvegicus 57-61 12679720-4 2003 This elimination was significantly inhibited by para-aminohippuric acid (PAH), benzylpenicillin, indoxyl sulfate, and cimetidine, suggesting the involvement of rat organic anion transporter 3 (rOAT3). p-Aminohippuric Acid 48-71 solute carrier family 22 member 8 Rattus norvegicus 193-198 12679720-4 2003 This elimination was significantly inhibited by para-aminohippuric acid (PAH), benzylpenicillin, indoxyl sulfate, and cimetidine, suggesting the involvement of rat organic anion transporter 3 (rOAT3). p-Aminohippuric Acid 73-76 solute carrier family 22 member 8 Rattus norvegicus 193-198 12679720-5 2003 rOAT3-expressing oocytes exhibited [3H]HVA uptake (K(m) = 274 micromol/L), which was inhibited by several organic anions, such as PAH, indoxyl sulfate, octanoic acid, and metabolites of monoamine neurotransmitters. p-Aminohippuric Acid 130-133 solute carrier family 22 member 8 Rattus norvegicus 0-5 12708754-0 2003 Role of BSP/bilirubin binding protein on p-aminohippurate transport in rat kidney. p-Aminohippuric Acid 41-57 integrin-binding sialoprotein Rattus norvegicus 8-37 12538807-6 2003 Finally, preloading cells transfected with hOAT1 with BTC significantly trans-stimulated the uptake of PAH, consistent with the conclusion that BTC and, hence, other cysteine S-conjugates are substrates for hOAT1. p-Aminohippuric Acid 103-106 solute carrier family 22 member 6 Homo sapiens 43-48 12538807-6 2003 Finally, preloading cells transfected with hOAT1 with BTC significantly trans-stimulated the uptake of PAH, consistent with the conclusion that BTC and, hence, other cysteine S-conjugates are substrates for hOAT1. p-Aminohippuric Acid 103-106 solute carrier family 22 member 6 Homo sapiens 207-212 12505323-9 2002 In summary, we have found that protection by GSTs against B[a]P or DiB[a,l]P toxicity is highly variable depending on differences in: (a) the PAH structure; (b) the human vs. rat CYP1A1 expressed; (c) GST isozyme(s) expressed; (d) cellular expression of conjugate transporters; or (e) DNA damage versus cytoxicity end-points. p-Aminohippuric Acid 142-145 glutathione S-transferase mu 1 Homo sapiens 45-49 12628298-6 2002 Heterologous expression of pOAT1 in Xenopus laevis oocytes revealed an apparent K(m) for [3H]PAH of 3.75 +/- 1.6 microM. p-Aminohippuric Acid 93-96 solute carrier family 22 member 6 Sus scrofa 27-32 12628298-7 2002 [3H]PAH uptake mediated by pOAT1 was abolished by 0.5 mM glutarate or 1 mM probenecid. p-Aminohippuric Acid 4-7 solute carrier family 22 member 6 Sus scrofa 27-32 12418443-7 2002 Intravenous epoprostenol and oral endothelin-1 receptor antagonists improve hemodynamic measurements and symptoms in SSc-associated PAH. p-Aminohippuric Acid 132-135 endothelin receptor type A Homo sapiens 34-55 12507920-2 2002 The ratio between CYP1A1 and GST enzyme activities is a critical determinant of the target dose of carcinogenic BPDE and other DNA-reactive PAH metabolites. p-Aminohippuric Acid 140-143 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 18-24 12507920-8 2002 These results are also consistent with the hypothesis that BP (PAH) induce G:C to T:A transversion mutations in the hotspot codons of the p53 tumor suppressor gene and are thus involved in malignant transformation of the lung tissue of smokers. p-Aminohippuric Acid 63-66 tumor protein p53 Homo sapiens 138-141 12110506-1 2002 Evaluation of renal hemodynamics requires estimation of effective renal plasma flow, which is commonly measured by the renal clearance of p-aminohippuric acid (PAH). p-Aminohippuric Acid 138-158 phenylalanine hydroxylase Homo sapiens 160-163 12119287-3 2002 Influx of [(14)C]formate into Slc26a6-expressing oocytes was inhibited by sulfate, oxalate, and p-aminohippurate (PAH), indicating affinity for these anions. p-Aminohippuric Acid 96-112 solute carrier family 26, member 6 Mus musculus 30-37 12119287-3 2002 Influx of [(14)C]formate into Slc26a6-expressing oocytes was inhibited by sulfate, oxalate, and p-aminohippurate (PAH), indicating affinity for these anions. p-Aminohippuric Acid 114-117 solute carrier family 26, member 6 Mus musculus 30-37 12119287-4 2002 Measurements of uptake of [(14)C]oxalate, [(14)C]PAH, and [(35)S]sulfate indicated that Slc26a6 can mediate transport of oxalate and sulfate but not PAH. p-Aminohippuric Acid 49-52 solute carrier family 26, member 6 Mus musculus 88-95 12428682-3 2002 The activity of PAH-AH in plasma was significantly increased 4-16 weeks after electroporation of apoE(-/-) mice with 120 microg of pcDNA/PAF-AH; the maximal (2.5-fold) increase was apparent after 8 weeks. p-Aminohippuric Acid 16-19 apolipoprotein E Mus musculus 97-101 12428682-3 2002 The activity of PAH-AH in plasma was significantly increased 4-16 weeks after electroporation of apoE(-/-) mice with 120 microg of pcDNA/PAF-AH; the maximal (2.5-fold) increase was apparent after 8 weeks. p-Aminohippuric Acid 16-19 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) Mus musculus 137-143 12237339-7 2002 Oat1-mediated uptake of [(14)C]MeHg-NAC and [(14)C]MeHg-DMPS was inhibited by prototypical substrates for Oat1, including p-aminohippurate (PAH), and was trans-stimulated when oocytes were preloaded with 2 mM glutarate but not glutamate. p-Aminohippuric Acid 122-138 solute carrier family 22 member 6 Rattus norvegicus 0-4 12237339-7 2002 Oat1-mediated uptake of [(14)C]MeHg-NAC and [(14)C]MeHg-DMPS was inhibited by prototypical substrates for Oat1, including p-aminohippurate (PAH), and was trans-stimulated when oocytes were preloaded with 2 mM glutarate but not glutamate. p-Aminohippuric Acid 122-138 solute carrier family 22 member 6 Rattus norvegicus 106-110 12237339-7 2002 Oat1-mediated uptake of [(14)C]MeHg-NAC and [(14)C]MeHg-DMPS was inhibited by prototypical substrates for Oat1, including p-aminohippurate (PAH), and was trans-stimulated when oocytes were preloaded with 2 mM glutarate but not glutamate. p-Aminohippuric Acid 140-143 solute carrier family 22 member 6 Rattus norvegicus 0-4 12237339-7 2002 Oat1-mediated uptake of [(14)C]MeHg-NAC and [(14)C]MeHg-DMPS was inhibited by prototypical substrates for Oat1, including p-aminohippurate (PAH), and was trans-stimulated when oocytes were preloaded with 2 mM glutarate but not glutamate. p-Aminohippuric Acid 140-143 solute carrier family 22 member 6 Rattus norvegicus 106-110 12237339-8 2002 Conversely, efflux of [(3)H]PAH from Oat1-expressing oocytes was trans-stimulated by glutarate, PAH, NAC, DMPS, MeHg-NAC, MeHg-DMPS, and a mercapturic acid, indicating that these are transported solutes. p-Aminohippuric Acid 28-31 solute carrier family 22 member 6 Rattus norvegicus 37-41 12237339-8 2002 Conversely, efflux of [(3)H]PAH from Oat1-expressing oocytes was trans-stimulated by glutarate, PAH, NAC, DMPS, MeHg-NAC, MeHg-DMPS, and a mercapturic acid, indicating that these are transported solutes. p-Aminohippuric Acid 96-99 solute carrier family 22 member 6 Rattus norvegicus 37-41 12237339-9 2002 [(3)H]PAH uptake was competitively inhibited by NAC (K(i) of 2.0 +/- 0.3 mM) and DMPS (K(i) of 0.10 +/- 0.02 mM), providing further evidence that these chelating agents are substrates for Oat1. p-Aminohippuric Acid 6-9 solute carrier family 22 member 6 Rattus norvegicus 188-192 12146840-0 2002 PAH-profiles in sediment cores from the Baltic Sea. p-Aminohippuric Acid 0-3 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 47-50 12138128-16 2002 Selective inhibition of COX2 by indomethacin amid or indomethacin n-heptyl ester did not inhibit [(14)C]PAH uptake, whereas selective inhibition of COX1 dose-dependently inhibited [(14)C]PAH uptake. p-Aminohippuric Acid 187-190 COX1 Didelphis virginiana 148-152 12102636-2 2002 The rat organic anion transporter, rOAT3, mediates the transport of organic anions such as p-aminohippurate (PAH) and estrone sulfate as well as the basic compound, cimetidine. p-Aminohippuric Acid 91-107 solute carrier family 22 member 8 Rattus norvegicus 35-40 12102636-2 2002 The rat organic anion transporter, rOAT3, mediates the transport of organic anions such as p-aminohippurate (PAH) and estrone sulfate as well as the basic compound, cimetidine. p-Aminohippuric Acid 109-112 solute carrier family 22 member 8 Rattus norvegicus 35-40 12102636-6 2002 We observed that four mutants in transmembrane domain 7 (TMD 7), W334A, F335A, Y341A, and Y342Q, and one mutant in transmembrane domain 8 (TMD 8), F362S, exhibited a less than 2-fold enhanced uptake of PAH and cimetidine in comparison to wild-type rOAT3, which exhibited a 16-fold enhanced uptake of PAH and an 8-fold enhanced uptake of cimetidine. p-Aminohippuric Acid 202-205 solute carrier family 22 member 8 Rattus norvegicus 248-253 12102636-6 2002 We observed that four mutants in transmembrane domain 7 (TMD 7), W334A, F335A, Y341A, and Y342Q, and one mutant in transmembrane domain 8 (TMD 8), F362S, exhibited a less than 2-fold enhanced uptake of PAH and cimetidine in comparison to wild-type rOAT3, which exhibited a 16-fold enhanced uptake of PAH and an 8-fold enhanced uptake of cimetidine. p-Aminohippuric Acid 300-303 solute carrier family 22 member 8 Rattus norvegicus 248-253 12102636-10 2002 We observed that the residues contribute to PAH and cimetidine transport in different ways: the -OH group of Y342, the indole ring of W334, and the aromatic rings of F335, Y341, and F362 are important for PAH and cimetidine transport by rOAT3. p-Aminohippuric Acid 44-47 solute carrier family 22 member 8 Rattus norvegicus 237-242 12102636-10 2002 We observed that the residues contribute to PAH and cimetidine transport in different ways: the -OH group of Y342, the indole ring of W334, and the aromatic rings of F335, Y341, and F362 are important for PAH and cimetidine transport by rOAT3. p-Aminohippuric Acid 205-208 solute carrier family 22 member 8 Rattus norvegicus 237-242 12102636-11 2002 These data suggest that there is an aromatic pocket composed mainly of residues in TMD 7 in the translocation pathway of rOAT3, which is important for the transport of PAH and cimetidine. p-Aminohippuric Acid 168-171 solute carrier family 22 member 8 Rattus norvegicus 121-126 12065749-6 2002 mOAT2-expressing oocytes also mediated the uptake of alpha-ketoglutarate, glutarate, prostaglandin E2, p-aminohippuric acid, methotrexate, ochratoxin A, valproate, and allopurinol. p-Aminohippuric Acid 103-123 solute carrier family 22 (organic anion transporter), member 7 Mus musculus 0-5 11961115-2 2002 In this study, we investigated the involvement of rat organic anion transporter 1 (rOat1; Slc22a6) and rOat3 (Slc22a8) in the uptake of PCG and p-aminohippurate (PAH) by the CP. p-Aminohippuric Acid 144-160 solute carrier family 22 member 6 Rattus norvegicus 54-81 12009881-1 2002 Previous studies of ferrous wild-type phenylalanine hydroxylase, [Fe(2+)]PAH(T)[], have shown the active site to be a six-coordinate distorted octahedral site. p-Aminohippuric Acid 73-76 phenylalanine hydroxylase Homo sapiens 38-63 12028803-6 2002 Moreover, HO-1 expression was positively correlated to the higher organic carbon (OC) and polyaromatic hydrocarbons (PAHs) content of fine versus coarse PM, as well as the rise in PAH content that occurs in coarse PM during the winter months. p-Aminohippuric Acid 117-120 heme oxygenase 1 Homo sapiens 10-14 11961115-2 2002 In this study, we investigated the involvement of rat organic anion transporter 1 (rOat1; Slc22a6) and rOat3 (Slc22a8) in the uptake of PCG and p-aminohippurate (PAH) by the CP. p-Aminohippuric Acid 144-160 solute carrier family 22 member 6 Rattus norvegicus 83-88 11961115-2 2002 In this study, we investigated the involvement of rat organic anion transporter 1 (rOat1; Slc22a6) and rOat3 (Slc22a8) in the uptake of PCG and p-aminohippurate (PAH) by the CP. p-Aminohippuric Acid 144-160 solute carrier family 22 member 6 Rattus norvegicus 90-97 11961115-2 2002 In this study, we investigated the involvement of rat organic anion transporter 1 (rOat1; Slc22a6) and rOat3 (Slc22a8) in the uptake of PCG and p-aminohippurate (PAH) by the CP. p-Aminohippuric Acid 144-160 solute carrier family 22 member 8 Rattus norvegicus 103-108 11961115-2 2002 In this study, we investigated the involvement of rat organic anion transporter 1 (rOat1; Slc22a6) and rOat3 (Slc22a8) in the uptake of PCG and p-aminohippurate (PAH) by the CP. p-Aminohippuric Acid 144-160 solute carrier family 22 member 8 Rattus norvegicus 110-117 11961115-10 2002 These results suggest that rOat3 is mainly responsible for the uptake of PCG and PAH by isolated rat CP, and it functions as one of the detoxification systems on the CP by removing its substrates from the cerebrospinal fluid. p-Aminohippuric Acid 81-84 solute carrier family 22 member 8 Rattus norvegicus 27-32 12083373-0 2002 Sex differences in p-aminohippuric acid transport in rat kidney: role of membrane fluidity and expression of OAT1. p-Aminohippuric Acid 19-39 solute carrier family 22 member 6 Rattus norvegicus 109-113 11897625-8 2002 Renal MRP2 function was evaluated by para-aminohippurate (PAH) clearance. p-Aminohippuric Acid 37-56 ATP binding cassette subfamily C member 2 Rattus norvegicus 6-10 11897625-8 2002 Renal MRP2 function was evaluated by para-aminohippurate (PAH) clearance. p-Aminohippuric Acid 58-61 ATP binding cassette subfamily C member 2 Rattus norvegicus 6-10 12083373-5 2002 The lower expression of OAT1 in BLMV in association with the higher BBMV fluidity (which may affect the affinity of PAH transporter in this membrane domain) observed in females may be responsible, at least in part, for the gender difference described in renal PAH secretion. p-Aminohippuric Acid 116-119 solute carrier family 22 member 6 Rattus norvegicus 24-28 11861777-5 2002 rOat1- and rOat3-expressed LLC-PK1 cells exhibited specific uptake of p-aminohippurate (PAH) and pravastatin, respectively, with the Michaelis-Menten constants (Km values) of 60 microM for rOat1-mediated PAH uptake and 13 microM for rOat3-mediated pravastatin uptake. p-Aminohippuric Acid 70-86 solute carrier family 22 member 6 Rattus norvegicus 0-5 12033380-6 2002 P-gp inhibitors (i.e., GG918, cyclosporine, ketoconazole, vinblastine) decreased the B-->A transport of dicloxacillin and trimethoprim and increased the A-->B transport of trimethoprim while non-P-gp inhibitors (e.g., PAH) had no effect. p-Aminohippuric Acid 224-227 ATP binding cassette subfamily B member 1 Homo sapiens 0-4 12005172-3 2002 Various cephalosporin antibiotics significantly inhibited both estrone sulfate uptake in S2 rOAT3 and para-aminohippuric acid uptake in S2 rOAT1. p-Aminohippuric Acid 102-125 solute carrier family 22 member 6 Rattus norvegicus 139-144 11861777-8 2002 This was also supported by the difference in the degree of inhibition by benzylpenicillin, a relatively selective inhibitor of rOat3, for the uptake of PAH and pravastatin by kidney slices. p-Aminohippuric Acid 152-155 solute carrier family 22 member 8 Rattus norvegicus 127-132 11861777-5 2002 rOat1- and rOat3-expressed LLC-PK1 cells exhibited specific uptake of p-aminohippurate (PAH) and pravastatin, respectively, with the Michaelis-Menten constants (Km values) of 60 microM for rOat1-mediated PAH uptake and 13 microM for rOat3-mediated pravastatin uptake. p-Aminohippuric Acid 70-86 solute carrier family 22 member 8 Rattus norvegicus 11-16 11861777-9 2002 These results suggest that rOat1 and rOat3 are mainly responsible for the renal uptake of PAH and pravastatin, respectively. p-Aminohippuric Acid 90-93 solute carrier family 22 member 6 Rattus norvegicus 27-32 11861777-9 2002 These results suggest that rOat1 and rOat3 are mainly responsible for the renal uptake of PAH and pravastatin, respectively. p-Aminohippuric Acid 90-93 solute carrier family 22 member 8 Rattus norvegicus 37-42 11861777-5 2002 rOat1- and rOat3-expressed LLC-PK1 cells exhibited specific uptake of p-aminohippurate (PAH) and pravastatin, respectively, with the Michaelis-Menten constants (Km values) of 60 microM for rOat1-mediated PAH uptake and 13 microM for rOat3-mediated pravastatin uptake. p-Aminohippuric Acid 70-86 solute carrier family 22 member 6 Rattus norvegicus 189-194 11861777-5 2002 rOat1- and rOat3-expressed LLC-PK1 cells exhibited specific uptake of p-aminohippurate (PAH) and pravastatin, respectively, with the Michaelis-Menten constants (Km values) of 60 microM for rOat1-mediated PAH uptake and 13 microM for rOat3-mediated pravastatin uptake. p-Aminohippuric Acid 70-86 solute carrier family 22 member 8 Rattus norvegicus 233-238 11861777-5 2002 rOat1- and rOat3-expressed LLC-PK1 cells exhibited specific uptake of p-aminohippurate (PAH) and pravastatin, respectively, with the Michaelis-Menten constants (Km values) of 60 microM for rOat1-mediated PAH uptake and 13 microM for rOat3-mediated pravastatin uptake. p-Aminohippuric Acid 88-91 solute carrier family 22 member 6 Rattus norvegicus 0-5 11861777-5 2002 rOat1- and rOat3-expressed LLC-PK1 cells exhibited specific uptake of p-aminohippurate (PAH) and pravastatin, respectively, with the Michaelis-Menten constants (Km values) of 60 microM for rOat1-mediated PAH uptake and 13 microM for rOat3-mediated pravastatin uptake. p-Aminohippuric Acid 88-91 solute carrier family 22 member 8 Rattus norvegicus 11-16 11861777-5 2002 rOat1- and rOat3-expressed LLC-PK1 cells exhibited specific uptake of p-aminohippurate (PAH) and pravastatin, respectively, with the Michaelis-Menten constants (Km values) of 60 microM for rOat1-mediated PAH uptake and 13 microM for rOat3-mediated pravastatin uptake. p-Aminohippuric Acid 88-91 solute carrier family 22 member 6 Rattus norvegicus 189-194 11861777-5 2002 rOat1- and rOat3-expressed LLC-PK1 cells exhibited specific uptake of p-aminohippurate (PAH) and pravastatin, respectively, with the Michaelis-Menten constants (Km values) of 60 microM for rOat1-mediated PAH uptake and 13 microM for rOat3-mediated pravastatin uptake. p-Aminohippuric Acid 88-91 solute carrier family 22 member 8 Rattus norvegicus 233-238 11861777-5 2002 rOat1- and rOat3-expressed LLC-PK1 cells exhibited specific uptake of p-aminohippurate (PAH) and pravastatin, respectively, with the Michaelis-Menten constants (Km values) of 60 microM for rOat1-mediated PAH uptake and 13 microM for rOat3-mediated pravastatin uptake. p-Aminohippuric Acid 204-207 solute carrier family 22 member 6 Rattus norvegicus 0-5 11861777-5 2002 rOat1- and rOat3-expressed LLC-PK1 cells exhibited specific uptake of p-aminohippurate (PAH) and pravastatin, respectively, with the Michaelis-Menten constants (Km values) of 60 microM for rOat1-mediated PAH uptake and 13 microM for rOat3-mediated pravastatin uptake. p-Aminohippuric Acid 204-207 solute carrier family 22 member 8 Rattus norvegicus 11-16 11684363-9 2001 p-Aminohippuric acid uptake impairment and glutamine synthetase activity loss caused by the highest doses of hexachloro-1:3-butadiene and potassium dichromate, respectively, suggests that high doses of segment-specific chemicals may involve other portions of the proximal tubule; in addition, the decrease of glutamine synthetase activity caused by potassium dichromate may be related to the protein content loss. p-Aminohippuric Acid 0-20 glutamate-ammonia ligase Rattus norvegicus 309-329 12139402-6 2002 Following heterologous expression in Xenopus laevis oocytes, flounder renal OAT1 transported p-aminohippurate, glutarate, several diuretics, and the nephrotoxic agent ochratoxin A. p-Aminohippuric Acid 93-109 solute carrier family 22 member 6 Oryctolagus cuniculus 76-80 11744606-8 2002 Ro 64-0802 was found to be a low-efficiency substrate for hOAT1 and a very weak inhibitor of hOAT1-mediated transport of p-aminohippuric acid (PAH). p-Aminohippuric Acid 121-141 solute carrier family 22 member 6 Homo sapiens 93-98 11744606-8 2002 Ro 64-0802 was found to be a low-efficiency substrate for hOAT1 and a very weak inhibitor of hOAT1-mediated transport of p-aminohippuric acid (PAH). p-Aminohippuric Acid 143-146 solute carrier family 22 member 6 Homo sapiens 93-98 15618660-4 2002 The inhibition constants of these cephalosporins to rOAT1-mediated p-aminohippurate (PAH) uptake were 72 microM for cefazolin, 298 microM for cefoperazone, 718 microM for cefotiam and 6 mM for cephalexin. p-Aminohippuric Acid 67-83 solute carrier family 22 member 6 Rattus norvegicus 52-57 15618660-4 2002 The inhibition constants of these cephalosporins to rOAT1-mediated p-aminohippurate (PAH) uptake were 72 microM for cefazolin, 298 microM for cefoperazone, 718 microM for cefotiam and 6 mM for cephalexin. p-Aminohippuric Acid 85-88 solute carrier family 22 member 6 Rattus norvegicus 52-57 15618660-5 2002 Eadie-Hofstee plot analysis revealed that cefoperazone as well as cefotiam inhibited rOAT1-mediated PAH uptake competitively. p-Aminohippuric Acid 100-103 solute carrier family 22 member 6 Rattus norvegicus 85-90 11602689-6 2001 [3H]PAH was used to show the transport activity of hOAT1 (Km = 3.9 +/-1.3 microM). p-Aminohippuric Acid 4-7 solute carrier family 22 member 6 Homo sapiens 51-56 11744606-10 2002 In contrast, probenecid effectively inhibited the transport of PAH, Ro 64-0802, and amoxicillin via hOAT1. p-Aminohippuric Acid 63-66 solute carrier family 22 member 6 Homo sapiens 100-105 11641438-5 2001 Uptake of [(3)H]p-aminohippuric acid (PAH) in Oat1-expressing Xenopus laevis oocytes was strongly inhibited by S-(2,4-dinitrophenyl)-N-acetyl-L-cysteine (DNP-NAC) and by all other mercapturic acids tested, including the endogenous mercapturic acid N-acetyl-leukotriene E(4). p-Aminohippuric Acid 38-41 solute carrier family 22 member 6 Rattus norvegicus 46-50 11535249-6 2001 Our results suggest interactions between GSTM1 and GSTP1 alleles in modulation of urinary 1-OHPY levels and white blood cell DNA adduct levels in the PAH-exposed workers. p-Aminohippuric Acid 150-153 glutathione S-transferase mu 1 Homo sapiens 41-46 11535249-6 2001 Our results suggest interactions between GSTM1 and GSTP1 alleles in modulation of urinary 1-OHPY levels and white blood cell DNA adduct levels in the PAH-exposed workers. p-Aminohippuric Acid 150-153 glutathione S-transferase pi 1 Homo sapiens 51-56 11504809-1 2001 An inhibitory effect of steviol, metabolite of the natural sweetener stevioside, on transepithelial transport of p-aminohippurate (J(PAH)) was observed in isolated S(2) segments of rabbit renal proximal tubules using in vitro microperfusion. p-Aminohippuric Acid 113-129 phenylalanine-4-hydroxylase Oryctolagus cuniculus 133-136 11698107-2 2001 Significant Gal9p-mediated transport could be demonstrated for [(14)C]-uric acid and for [(14)C]-PAH(1). p-Aminohippuric Acid 97-100 galectin 9 Homo sapiens 12-17 11408557-7 2001 PAH did not affect the transport via the Oatp family, but had a similar affinity for Oat1 and Oat3 (85 and 300 microM, respectively). p-Aminohippuric Acid 0-3 solute carrier family 22 member 6 Sus scrofa 85-89 11504818-5 2001 The affinity of PAH, a common substrate for the OAT family, for rOat2 is low (K(i) > 1 mM) compared with the other members of the OAT family (rOat1 and rOat3). p-Aminohippuric Acid 16-19 solute carrier family 22 (organic anion transporter), member 7, pseudogene 1 Rattus norvegicus 64-69 11504818-5 2001 The affinity of PAH, a common substrate for the OAT family, for rOat2 is low (K(i) > 1 mM) compared with the other members of the OAT family (rOat1 and rOat3). p-Aminohippuric Acid 16-19 solute carrier family 22 member 6 Rattus norvegicus 145-150 11504818-5 2001 The affinity of PAH, a common substrate for the OAT family, for rOat2 is low (K(i) > 1 mM) compared with the other members of the OAT family (rOat1 and rOat3). p-Aminohippuric Acid 16-19 solute carrier family 22 member 8 Rattus norvegicus 155-160 11470901-7 2001 Xenopus oocytes injected with the cRNA for both Ostalpha and Ostbeta, but not each separately, were able to take up taurocholate, estrone sulfate, digoxin, and prostaglandin E(2), but not p-aminohippurate or S-dinitrophenyl glutathione. p-Aminohippuric Acid 188-204 solute carrier family 51 alpha subunit S homeolog Xenopus laevis 48-56 11408557-7 2001 PAH did not affect the transport via the Oatp family, but had a similar affinity for Oat1 and Oat3 (85 and 300 microM, respectively). p-Aminohippuric Acid 0-3 solute carrier family 22 member 8 Sus scrofa 94-98 11331016-6 2001 The uptakes of p-aminohippurate (PAH), estrone sulfate, and ochratoxin A were approximately 10-, approximately 48-, and approximately 32-fold enhanced in oocytes expressing rOAT3 and were only approximately 2-, approximately 6-, and approximately 5-fold enhanced for R454D. p-Aminohippuric Acid 15-31 solute carrier family 22 member 8 Rattus norvegicus 173-178 11443229-2 2001 Uptake of PAH from blood into tubule cells occurs by exchange with intracellular alpha-ketoglutarate and is mediated by the organic anion transporter 1. p-Aminohippuric Acid 10-13 solute carrier family 22 member 6 Homo sapiens 124-151 11331016-6 2001 The uptakes of p-aminohippurate (PAH), estrone sulfate, and ochratoxin A were approximately 10-, approximately 48-, and approximately 32-fold enhanced in oocytes expressing rOAT3 and were only approximately 2-, approximately 6-, and approximately 5-fold enhanced for R454D. p-Aminohippuric Acid 33-36 solute carrier family 22 member 8 Rattus norvegicus 173-178 11331016-8 2001 Interestingly, the charge specificity of the double mutant, R454DK370A, was reversed in comparison to rOAT3-R454DK370A preferentially transported the organic cation, MPP(+), in comparison to PAH (MPP(+) uptake/PAH uptake = 3.21 for the double mutant vs 0.037 for rOAT3). p-Aminohippuric Acid 191-194 solute carrier family 22 member 8 Rattus norvegicus 102-107 11331016-8 2001 Interestingly, the charge specificity of the double mutant, R454DK370A, was reversed in comparison to rOAT3-R454DK370A preferentially transported the organic cation, MPP(+), in comparison to PAH (MPP(+) uptake/PAH uptake = 3.21 for the double mutant vs 0.037 for rOAT3). p-Aminohippuric Acid 191-194 solute carrier family 22 member 8 Rattus norvegicus 263-268 11331016-8 2001 Interestingly, the charge specificity of the double mutant, R454DK370A, was reversed in comparison to rOAT3-R454DK370A preferentially transported the organic cation, MPP(+), in comparison to PAH (MPP(+) uptake/PAH uptake = 3.21 for the double mutant vs 0.037 for rOAT3). p-Aminohippuric Acid 210-213 solute carrier family 22 member 8 Rattus norvegicus 102-107 11331016-8 2001 Interestingly, the charge specificity of the double mutant, R454DK370A, was reversed in comparison to rOAT3-R454DK370A preferentially transported the organic cation, MPP(+), in comparison to PAH (MPP(+) uptake/PAH uptake = 3.21 for the double mutant vs 0.037 for rOAT3). p-Aminohippuric Acid 210-213 solute carrier family 22 member 8 Rattus norvegicus 263-268 11135083-5 2001 RESULTS: Concentration-dependent renal clearance of PAH was observed at plasma concentrations> 100 mg/L; renal clearances were 442 +/- 131 (mean +/- SD), 423 +/- 94, 233 +/- 45, and 152 +/- 18 mL/min/1.73 m2 at plasma concentrations of 18 +/- 2, 92 +/- 5, 291 +/- 47 and 789 +/- 28 mg/L, respectively. p-Aminohippuric Acid 52-55 CD59 molecule (CD59 blood group) Homo sapiens 199-204 11327718-3 2001 hOAT1- and hOAT3-transfected cells showed uptake of p-aminohippurate and fluorescein. p-Aminohippuric Acid 52-68 solute carrier family 22 member 6 Homo sapiens 0-5 11327718-3 2001 hOAT1- and hOAT3-transfected cells showed uptake of p-aminohippurate and fluorescein. p-Aminohippuric Acid 52-68 solute carrier family 22 member 8 Homo sapiens 11-16 11327718-4 2001 Cells expressing hOAT2 showed uptake of p-aminohippurate, methotrexate, cAMP, and alpha-ketoglutarate. p-Aminohippuric Acid 40-56 solute carrier family 22 member 7 Homo sapiens 17-22 11288487-6 2001 OAT1 mediates sodium-independent, anion exchange for a variety of organic anions including p-aminohippurate, cyclic nucleotides, prostanoides, dicarboxylates, and anionic drugs including beta-lactams, non-steroidal antiinflammatory drugs, diuretics and antiviral drugs. p-Aminohippuric Acid 91-107 solute carrier family 22 member 6 Rattus norvegicus 0-4 11306713-5 2001 When expressed in Xenopus laevis oocytes, hOAT3 mediated the transport of estrone sulfate (K(m) = 3.1 microM), p-aminohippurate (K(m) = 87.2 microM), methotrexate (K(m) = 10.9 microM), and cimetidine (K(m) = 57.4 microM) in a sodium-independent manner. p-Aminohippuric Acid 111-127 solute carrier family 22 member 8 Homo sapiens 42-47 11206195-1 2001 The intestinal transport of an organic anion, p-aminohippuric acid (PAH), was studied in Caco-2 cell monolayers and rat intestinal tissue mounted in Ussing chambers. p-Aminohippuric Acid 46-66 phenylalanine hydroxylase Homo sapiens 68-71 11054538-1 2000 Tetrapod cytochrome P4501 family (CYP1A1, CYP1A2 and CYP1B1) enzymes are most active in hydroxylating a variety of environmental contaminants including polyaromatic hydrocarbons (PAH), planar polychlorinated biphenyls and arylamines and thus play a pivotal role in the toxicology of these compounds. p-Aminohippuric Acid 179-182 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 34-40 11054538-1 2000 Tetrapod cytochrome P4501 family (CYP1A1, CYP1A2 and CYP1B1) enzymes are most active in hydroxylating a variety of environmental contaminants including polyaromatic hydrocarbons (PAH), planar polychlorinated biphenyls and arylamines and thus play a pivotal role in the toxicology of these compounds. p-Aminohippuric Acid 179-182 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 42-48 11054538-1 2000 Tetrapod cytochrome P4501 family (CYP1A1, CYP1A2 and CYP1B1) enzymes are most active in hydroxylating a variety of environmental contaminants including polyaromatic hydrocarbons (PAH), planar polychlorinated biphenyls and arylamines and thus play a pivotal role in the toxicology of these compounds. p-Aminohippuric Acid 179-182 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 53-59 11049063-4 2000 The relative time taken by a pulse dose of p-amino hippuric acid (PAH) injected into the EPV, to reach the EPA and the MV, was measured in a first trial. p-Aminohippuric Acid 43-64 phenylalanine hydroxylase Bos taurus 66-69 10997921-0 2000 Multidrug resistance protein mrp2 mediates ATP-dependent transport of classic renal organic anion p-aminohippurate. p-Aminohippuric Acid 98-114 canalicular multispecific organic anion transporter 1 Oryctolagus cuniculus 29-33 10997921-3 2000 In this study we investigated whether PAH is a substrate for the apical multidrug resistance protein 2 (Mrp2). p-Aminohippuric Acid 38-41 canalicular multispecific organic anion transporter 1 Oryctolagus cuniculus 72-102 10997921-3 2000 In this study we investigated whether PAH is a substrate for the apical multidrug resistance protein 2 (Mrp2). p-Aminohippuric Acid 38-41 canalicular multispecific organic anion transporter 1 Oryctolagus cuniculus 104-108 10997921-4 2000 Overexpression of recombinant rabbit Mrp2 in Sf9 cells significantly increased ATP-dependent [(14)C]PAH uptake into isolated membrane vesicles compared with endogenous ATP-dependent uptake. p-Aminohippuric Acid 100-103 canalicular multispecific organic anion transporter 1 Oryctolagus cuniculus 37-41 10997921-5 2000 The Michaelis-Menten constant and maximal velocity for Mrp2-mediated ATP-dependent [(14)C]PAH transport were 1.9 +/- 0.8 mM and 187 +/- 29 pmol. p-Aminohippuric Acid 90-93 canalicular multispecific organic anion transporter 1 Oryctolagus cuniculus 55-59 10997921-9 2000 Together, our results show that Mrp2 is a low-affinity ATP-dependent PAH transporter, indicating that Mrp2 might contribute to urinary PAH excretion. p-Aminohippuric Acid 69-72 canalicular multispecific organic anion transporter 1 Oryctolagus cuniculus 32-36 10997921-9 2000 Together, our results show that Mrp2 is a low-affinity ATP-dependent PAH transporter, indicating that Mrp2 might contribute to urinary PAH excretion. p-Aminohippuric Acid 69-72 canalicular multispecific organic anion transporter 1 Oryctolagus cuniculus 102-106 10991988-8 2000 [(14)C]PAH efflux was significantly enhanced when the rOAT1-expressing oocytes were incubated in the presence of unlabeled PAH, alpha-ketoglutarate, acetazolamide, chlorothiazide, or hydrochlorothiazide. p-Aminohippuric Acid 7-10 solute carrier family 22 member 6 Rattus norvegicus 54-59 10991988-8 2000 [(14)C]PAH efflux was significantly enhanced when the rOAT1-expressing oocytes were incubated in the presence of unlabeled PAH, alpha-ketoglutarate, acetazolamide, chlorothiazide, or hydrochlorothiazide. p-Aminohippuric Acid 123-126 solute carrier family 22 member 6 Rattus norvegicus 54-59 10991988-4 2000 p-[(14)C]Aminohippurate (PAH) uptake by rOAT1-expressing oocytes was inhibited in the presence of a thiazide (chlorothiazide, cyclothiazide, hydrochlorothiazide), a loop diuretic (bumetanide, ethacrynic acid, furosemide), or a carbonic anhydrase inhibitor (acetazolamide, ethoxzolamide, methazolamide). p-Aminohippuric Acid 25-28 solute carrier family 22 member 6 Rattus norvegicus 40-45 10854830-2 2000 Uptake of p-aminohippurate via rOAT1 was markedly inhibited by glibenclamide and nateglinide, and moderately by chlorpropamide and tolbutamide. p-Aminohippuric Acid 10-26 solute carrier family 22 member 6 Rattus norvegicus 31-36 10712743-2 2000 GSTP1 and GSTM1 are mainly involved in detoxification reactions of PAH carcinogenic intermediates produced by cytochrome P450 (CYP). p-Aminohippuric Acid 67-70 glutathione S-transferase pi 1 Homo sapiens 0-5 10744714-8 2000 We report here that both protein phosphatase (PP1/PP2A) inhibitor, okadaic acid, and protein kinase C (PKC) activators down-regulate mOAT-mediated transport of para-aminohippuric acid (PAH), a prototypic organic anion, in a time- and concentrationdependent manner. p-Aminohippuric Acid 160-183 protein phosphatase 1 catalytic subunit gamma Mus musculus 46-49 10744714-8 2000 We report here that both protein phosphatase (PP1/PP2A) inhibitor, okadaic acid, and protein kinase C (PKC) activators down-regulate mOAT-mediated transport of para-aminohippuric acid (PAH), a prototypic organic anion, in a time- and concentrationdependent manner. p-Aminohippuric Acid 160-183 protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform Mus musculus 50-54 10744714-8 2000 We report here that both protein phosphatase (PP1/PP2A) inhibitor, okadaic acid, and protein kinase C (PKC) activators down-regulate mOAT-mediated transport of para-aminohippuric acid (PAH), a prototypic organic anion, in a time- and concentrationdependent manner. p-Aminohippuric Acid 185-188 protein phosphatase 1 catalytic subunit gamma Mus musculus 46-49 10744714-8 2000 We report here that both protein phosphatase (PP1/PP2A) inhibitor, okadaic acid, and protein kinase C (PKC) activators down-regulate mOAT-mediated transport of para-aminohippuric acid (PAH), a prototypic organic anion, in a time- and concentrationdependent manner. p-Aminohippuric Acid 185-188 protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform Mus musculus 50-54 10760098-0 2000 ATP-dependent para-aminohippurate transport by apical multidrug resistance protein MRP2. p-Aminohippuric Acid 14-33 ATP binding cassette subfamily C member 2 Homo sapiens 83-87 10760098-1 2000 BACKGROUND: Para-aminohippurate (PAH), a widely used model substrate for organic anion transport in proximal tubule epithelia, was investigated as a substrate for the apical multidrug resistance protein MRP2 (symbol ABCC2). p-Aminohippuric Acid 12-31 ATP binding cassette subfamily C member 2 Homo sapiens 203-207 10760098-1 2000 BACKGROUND: Para-aminohippurate (PAH), a widely used model substrate for organic anion transport in proximal tubule epithelia, was investigated as a substrate for the apical multidrug resistance protein MRP2 (symbol ABCC2). p-Aminohippuric Acid 12-31 ATP binding cassette subfamily C member 2 Homo sapiens 216-221 10760098-1 2000 BACKGROUND: Para-aminohippurate (PAH), a widely used model substrate for organic anion transport in proximal tubule epithelia, was investigated as a substrate for the apical multidrug resistance protein MRP2 (symbol ABCC2). p-Aminohippuric Acid 33-36 ATP binding cassette subfamily C member 2 Homo sapiens 203-207 10760098-1 2000 BACKGROUND: Para-aminohippurate (PAH), a widely used model substrate for organic anion transport in proximal tubule epithelia, was investigated as a substrate for the apical multidrug resistance protein MRP2 (symbol ABCC2). p-Aminohippuric Acid 33-36 ATP binding cassette subfamily C member 2 Homo sapiens 216-221 10760098-5 2000 RESULTS: Transport rates at 10 micromol/L PAH were 21.9 +/- 1.9 and 1.6 +/- 0.4 pmol x mg protein-1 x min-1 (means +/- SEM, N = 10) with membrane vesicles from HEK-MRP2 and HEK-Co cells, respectively. p-Aminohippuric Acid 42-45 CD59 molecule (CD59 blood group) Homo sapiens 102-107 10760098-7 2000 The high-affinity substrate leukotriene C4 and the inhibitor of MRP-mediated transport, MK571, inhibited MRP2-mediated transport of PAH (100 nmol/L) with IC50 values of 3.3 and 4.0 micromol/L, respectively. p-Aminohippuric Acid 132-135 ATP binding cassette subfamily C member 1 Homo sapiens 64-67 10760098-7 2000 The high-affinity substrate leukotriene C4 and the inhibitor of MRP-mediated transport, MK571, inhibited MRP2-mediated transport of PAH (100 nmol/L) with IC50 values of 3.3 and 4.0 micromol/L, respectively. p-Aminohippuric Acid 132-135 ATP binding cassette subfamily C member 2 Homo sapiens 105-109 10760098-8 2000 The nephrotoxic mycotoxin ochratoxin A inhibited MRP2-mediated PAH transport with an IC50 value of 58 micromol/L. p-Aminohippuric Acid 63-66 ATP binding cassette subfamily C member 2 Homo sapiens 49-53 10760098-10 2000 CONCLUSIONS: PAH is a good substrate for the ATP-dependent export pump MRP2. p-Aminohippuric Acid 13-16 ATP binding cassette subfamily C member 2 Homo sapiens 71-75 10760098-11 2000 The localization and function of MRP2 indicate that this unidirectional transport protein contributes to the secretion of PAH and other amphiphilic anions into the lumen of kidney proximal tubules. p-Aminohippuric Acid 122-125 ATP binding cassette subfamily C member 2 Homo sapiens 33-37 10733936-0 2000 p-aminohippuric acid transport at renal apical membrane mediated by human inorganic phosphate transporter NPT1. p-Aminohippuric Acid 0-20 solute carrier family 17 member 1 Homo sapiens 106-110 10733936-3 2000 In the present study, we showed that human NPT1, which is present in renal apical membrane, mediates the transport of PAH. p-Aminohippuric Acid 118-121 solute carrier family 17 member 1 Homo sapiens 43-47 10733936-8 2000 Considering its chloride ion sensitivity, Npt1 is expected to function for secretion of PAH from renal proximal tubular cells. p-Aminohippuric Acid 88-91 solute carrier family 17 member 1 Homo sapiens 42-46 10712743-2 2000 GSTP1 and GSTM1 are mainly involved in detoxification reactions of PAH carcinogenic intermediates produced by cytochrome P450 (CYP). p-Aminohippuric Acid 67-70 glutathione S-transferase mu 1 Homo sapiens 10-15 10712743-2 2000 GSTP1 and GSTM1 are mainly involved in detoxification reactions of PAH carcinogenic intermediates produced by cytochrome P450 (CYP). p-Aminohippuric Acid 67-70 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 110-125 10712743-2 2000 GSTP1 and GSTM1 are mainly involved in detoxification reactions of PAH carcinogenic intermediates produced by cytochrome P450 (CYP). p-Aminohippuric Acid 67-70 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 127-130 10712743-4 2000 In this study, we examined the effect of common polymorphism in exon 5 (105Ile --> Val) of the GSTP1 gene, alone and in combination with GSTM1-deletion polymorphism, on the level of PAH-DNA adducts measured by (32)P-postlabeling assay in mononuclear white blood cells collected in winter and in summer from a total of 170 healthy volunteers. p-Aminohippuric Acid 185-188 glutathione S-transferase pi 1 Homo sapiens 98-103 10712743-10 2000 Our data show that the combined GSTM1 and GSTP1 genetic polymorphisms may modulate PAH-DNA adduct levels in mononuclear WBCs from individuals exposed to specific carcinogenic compounds, e.g., tobacco smoke, in relatively lower-exposure environmental conditions (i.e., in summer). p-Aminohippuric Acid 83-86 glutathione S-transferase mu 1 Homo sapiens 32-37 10712743-10 2000 Our data show that the combined GSTM1 and GSTP1 genetic polymorphisms may modulate PAH-DNA adduct levels in mononuclear WBCs from individuals exposed to specific carcinogenic compounds, e.g., tobacco smoke, in relatively lower-exposure environmental conditions (i.e., in summer). p-Aminohippuric Acid 83-86 glutathione S-transferase pi 1 Homo sapiens 42-47 11076426-4 2000 RESULTS: PAH patients showed quantitative alterations in erythrocyte membrane protein composition: increased content of alpha-spectrin, ankyrin (band 2.1), anion exchange protein (band 3) and decreased content of actin, tropomyosin and glutathione-S-transferase. p-Aminohippuric Acid 9-12 glutathione S-transferase kappa 1 Homo sapiens 236-261 10411577-2 1999 [(14)C]p-Aminohippurate (PAH) uptake via OAT1 expressed in Xenopus laevis oocytes was inhibited by all of the penicillins and cephalosporins tested. p-Aminohippuric Acid 7-23 solute carrier family 22 member 6 Rattus norvegicus 41-45 10631125-1 2000 UDP-glucuronosyltransferase 1A7 (UGT1A7) is a polyaromatic hydrocarbon (PAH)-inducible UGT with activity toward various benzo[a]pyrene (B[a]P) metabolites. p-Aminohippuric Acid 72-75 UDP glucuronosyltransferase family 1 member A7 Homo sapiens 0-31 10631125-1 2000 UDP-glucuronosyltransferase 1A7 (UGT1A7) is a polyaromatic hydrocarbon (PAH)-inducible UGT with activity toward various benzo[a]pyrene (B[a]P) metabolites. p-Aminohippuric Acid 72-75 UDP glucuronosyltransferase family 1 member A7 Homo sapiens 33-39 10631125-1 2000 UDP-glucuronosyltransferase 1A7 (UGT1A7) is a polyaromatic hydrocarbon (PAH)-inducible UGT with activity toward various benzo[a]pyrene (B[a]P) metabolites. p-Aminohippuric Acid 72-75 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 33-36 10493307-2 1999 In the study, the effect of the GSTM1, GSTP1, CYP1A1 and CYP2D6 polymorphisms was investigated in relation to PAH-DNA adduct levels in non-tumourous lung tissue from non-small cell lung cancer (NSCLC) patients living in the industrialized region of Upper Silesia, Poland. p-Aminohippuric Acid 110-113 glutathione S-transferase mu 1 Homo sapiens 32-37 10493307-2 1999 In the study, the effect of the GSTM1, GSTP1, CYP1A1 and CYP2D6 polymorphisms was investigated in relation to PAH-DNA adduct levels in non-tumourous lung tissue from non-small cell lung cancer (NSCLC) patients living in the industrialized region of Upper Silesia, Poland. p-Aminohippuric Acid 110-113 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 46-52 10493307-2 1999 In the study, the effect of the GSTM1, GSTP1, CYP1A1 and CYP2D6 polymorphisms was investigated in relation to PAH-DNA adduct levels in non-tumourous lung tissue from non-small cell lung cancer (NSCLC) patients living in the industrialized region of Upper Silesia, Poland. p-Aminohippuric Acid 110-113 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 57-63 10493307-10 1999 Thus, our findings imply that the GSTMI and CYP1A1 exon 7 polymorphisms may influence PAH-DNA adduct levels in target tissue from NSCLC patients, especially in the squamous cell carcinoma group. p-Aminohippuric Acid 86-89 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 44-50 10631125-9 2000 These data suggest that UGT1A7 may be preferentially active toward B[a]P-quinones and that UGT1A7 may represent the PAH-inducible UGT activity previously implicated in protection against toxic redox cycling by B[a]P-3,6-quinone. p-Aminohippuric Acid 116-119 UDP glucuronosyltransferase family 1 member A7 Homo sapiens 91-97 10650914-2 1999 In order to assess whether the levels of some biomarkers (PAH-DNA adducts, nitro-PAH adducts to Hb and MN frequency) could be modulated by the genetic metabolic polymorphisms for CYP1A1 and GSTM1, we analysed in 76 coke-oven workers and 18 controls the CYP1A1 (MspI and Ile/Val sites) and the GSTM1 genotypes by a PCR assay. p-Aminohippuric Acid 58-61 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 179-185 10650914-2 1999 In order to assess whether the levels of some biomarkers (PAH-DNA adducts, nitro-PAH adducts to Hb and MN frequency) could be modulated by the genetic metabolic polymorphisms for CYP1A1 and GSTM1, we analysed in 76 coke-oven workers and 18 controls the CYP1A1 (MspI and Ile/Val sites) and the GSTM1 genotypes by a PCR assay. p-Aminohippuric Acid 81-84 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 179-185 10650914-4 1999 Statistically significant (P = 0.03 and P = 0.01) higher percentages of the more susceptible GSTM1- subjects compared to the GSTM1+ subjects and of the more susceptible CYP1A1 Ile/Val individuals compared to the CYP1A1 Ile/Ile individuals were detected for high levels of PAH-DNA adducts in the high exposure group (namely high levels of 1-OHP). p-Aminohippuric Acid 272-275 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 169-175 10650914-5 1999 A statistically significant association was observed between increased PAH-DNA adduct levels and the more susceptible GSTM1- genotype (P.O.R. p-Aminohippuric Acid 71-74 glutathione S-transferase mu 1 Homo sapiens 118-123 10650914-6 1999 = 4.18, P = 0.03) in a logistic regression modelling and a significant interaction between PAH exposure and GSTM1-genotype was found for PAH-DNA adducts. p-Aminohippuric Acid 91-94 glutathione S-transferase mu 1 Homo sapiens 108-113 10650914-6 1999 = 4.18, P = 0.03) in a logistic regression modelling and a significant interaction between PAH exposure and GSTM1-genotype was found for PAH-DNA adducts. p-Aminohippuric Acid 137-140 glutathione S-transferase mu 1 Homo sapiens 108-113 10650914-8 1999 In conclusion, a gene-environment interaction between PAH exposure and two metabolic genotypes involved in activation (CYP1A1) and detoxification (GSTM1) of PAHs, respectively, has been identified. p-Aminohippuric Acid 54-57 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 119-125 10650914-8 1999 In conclusion, a gene-environment interaction between PAH exposure and two metabolic genotypes involved in activation (CYP1A1) and detoxification (GSTM1) of PAHs, respectively, has been identified. p-Aminohippuric Acid 54-57 glutathione S-transferase mu 1 Homo sapiens 147-152 10525077-5 1999 CeOAT1 transports p-aminohippurate (PAH) in a Na(+)-independent manner. p-Aminohippuric Acid 18-34 MFS domain-containing protein Caenorhabditis elegans 0-6 10525077-5 1999 CeOAT1 transports p-aminohippurate (PAH) in a Na(+)-independent manner. p-Aminohippuric Acid 36-39 MFS domain-containing protein Caenorhabditis elegans 0-6 10525077-6 1999 The transport mechanism appears to involve anion exchange because CeOAT1-mediated PAH transport is stimulated by a cell-to-medium concentration gradient of alpha-ketoglutarate or fumarate generated by coexpression in the cells of a mammalian Na(+)-coupled dicarboxylate transporter. p-Aminohippuric Acid 82-85 MFS domain-containing protein Caenorhabditis elegans 66-72 10613181-0 1999 Mutagenicity of C24H14 PAH in human cells expressing CYP1A1. p-Aminohippuric Acid 23-26 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 53-59 10613181-3 1999 h1A1v2 cells are a line of human B-lymphoblastoid cells that have been engineered to express cytochrome P4501A1 (CYP1A1), an enzyme capable of metabolizing promutagenic PAH. p-Aminohippuric Acid 169-172 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 93-111 10613181-3 1999 h1A1v2 cells are a line of human B-lymphoblastoid cells that have been engineered to express cytochrome P4501A1 (CYP1A1), an enzyme capable of metabolizing promutagenic PAH. p-Aminohippuric Acid 169-172 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 113-119 10411577-2 1999 [(14)C]p-Aminohippurate (PAH) uptake via OAT1 expressed in Xenopus laevis oocytes was inhibited by all of the penicillins and cephalosporins tested. p-Aminohippuric Acid 25-28 solute carrier family 22 member 6 Rattus norvegicus 41-45 10411577-3 1999 Penicillin G, carbenicillin, cephaloridine, cephalothin, cefazolin, and cephalexin inhibited [(14)C]PAH uptake via OAT1 in a competitive manner (K(i) = 0.29-2.33 mM). p-Aminohippuric Acid 100-103 solute carrier family 22 member 6 Rattus norvegicus 115-119 10411577-4 1999 Cinoxacin, a quinolone gyrase inhibitor, also inhibited PAH uptake via OAT1. p-Aminohippuric Acid 56-59 solute carrier family 22 member 6 Rattus norvegicus 71-75 10224140-5 1999 When expressed in Xenopus laevis oocytes, OAT3 mediated the uptake of organic anions, such as p-aminohippurate (Km = 65 microM), ochratoxin A (Km = 0.74 microM), and estrone sulfate (Km = 2.3 microM) and a cationic compound, cimetidine. p-Aminohippuric Acid 94-110 solute carrier family 22 member 8 Rattus norvegicus 42-46 10445389-0 1999 Influence of epidermal growth factor (EGF) on renal transport of PAH and amino acids in amino acid loaded rats. p-Aminohippuric Acid 65-68 epidermal growth factor like 1 Rattus norvegicus 38-41 10445389-1 1999 In anaesthetized adult female rats, the influence of epidermal growth factor (EGF) on renal transport of p-amino-hippurate (PAH), electrolytes, and amino acids was investigated. p-Aminohippuric Acid 105-122 epidermal growth factor like 1 Rattus norvegicus 53-76 10445389-1 1999 In anaesthetized adult female rats, the influence of epidermal growth factor (EGF) on renal transport of p-amino-hippurate (PAH), electrolytes, and amino acids was investigated. p-Aminohippuric Acid 105-122 epidermal growth factor like 1 Rattus norvegicus 78-81 10445389-1 1999 In anaesthetized adult female rats, the influence of epidermal growth factor (EGF) on renal transport of p-amino-hippurate (PAH), electrolytes, and amino acids was investigated. p-Aminohippuric Acid 124-127 epidermal growth factor like 1 Rattus norvegicus 78-81 10359894-10 1999 Moreover, supernatants from DEP-PAH-activated cells, compared with those of controls, exhibited a significantly enhanced chemotactic activity for neutrophils and eosinophils, which was significantly inhibited by pretreatment with anti-IL-8 and anti-RANTES neutralizing antibodies, respectively. p-Aminohippuric Acid 32-35 C-X-C motif chemokine ligand 8 Homo sapiens 235-239 10359894-10 1999 Moreover, supernatants from DEP-PAH-activated cells, compared with those of controls, exhibited a significantly enhanced chemotactic activity for neutrophils and eosinophils, which was significantly inhibited by pretreatment with anti-IL-8 and anti-RANTES neutralizing antibodies, respectively. p-Aminohippuric Acid 32-35 C-C motif chemokine ligand 5 Homo sapiens 249-255 10049739-1 1999 The cloned organic anion transporters from rat, mouse, and winter flounder (rOAT1, mOAT1, fROAT) mediate the coupled exchange of alpha-ketoglutarate with multiple organic anions, including p-aminohippurate (PAH). p-Aminohippuric Acid 189-205 solute carrier family 22 member 6 Rattus norvegicus 76-81 10335444-2 1999 Evidence for at least two PAH-inducible UGTs (UGT1A6 and UGT1A9) is presented, which, however, are also constitutively expressed in a tissue- and cell-specific manner. p-Aminohippuric Acid 26-29 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 46-52 10335444-2 1999 Evidence for at least two PAH-inducible UGTs (UGT1A6 and UGT1A9) is presented, which, however, are also constitutively expressed in a tissue- and cell-specific manner. p-Aminohippuric Acid 26-29 UDP glucuronosyltransferase family 1 member A9 Homo sapiens 57-63 10224318-2 1999 CYP1A2 is induced by and metabolizes polyaromatic hydrocarbons (PAH) and aromatic amines and could modify effects of exposure to ambient air pollution. p-Aminohippuric Acid 64-67 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 0-6 10049739-1 1999 The cloned organic anion transporters from rat, mouse, and winter flounder (rOAT1, mOAT1, fROAT) mediate the coupled exchange of alpha-ketoglutarate with multiple organic anions, including p-aminohippurate (PAH). p-Aminohippuric Acid 189-205 solute carrier family 22 (organic anion transporter), member 6 Mus musculus 83-88 10049739-1 1999 The cloned organic anion transporters from rat, mouse, and winter flounder (rOAT1, mOAT1, fROAT) mediate the coupled exchange of alpha-ketoglutarate with multiple organic anions, including p-aminohippurate (PAH). p-Aminohippuric Acid 207-210 solute carrier family 22 member 6 Rattus norvegicus 76-81 10049739-1 1999 The cloned organic anion transporters from rat, mouse, and winter flounder (rOAT1, mOAT1, fROAT) mediate the coupled exchange of alpha-ketoglutarate with multiple organic anions, including p-aminohippurate (PAH). p-Aminohippuric Acid 207-210 solute carrier family 22 (organic anion transporter), member 6 Mus musculus 83-88 10049739-6 1999 PAH uptake by Xenopus laevis oocytes injected with hOAT1 mRNA is increased 100-fold compared to water-injected oocytes. p-Aminohippuric Acid 0-3 solute carrier family 22 member 6 Homo sapiens 51-56 9887087-4 1999 When expressed in Xenopus laevis oocytes, hOAT1 mediated sodium-independent uptake of p-aminohippurate (PAH) (Km = 9. p-Aminohippuric Acid 86-102 solute carrier family 22 member 6 Homo sapiens 42-47 9887087-4 1999 When expressed in Xenopus laevis oocytes, hOAT1 mediated sodium-independent uptake of p-aminohippurate (PAH) (Km = 9. p-Aminohippuric Acid 104-107 solute carrier family 22 member 6 Homo sapiens 42-47 9887087-6 1999 hOAT1-mediated PAH uptake was inhibited by bulky inorganic anions, various xenobiotics, and endogenous substances, including benzylpenicillin, furosemide, indomethacin, probenecid, phenol red, urate, and alpha-ketoglutarate. p-Aminohippuric Acid 15-18 solute carrier family 22 member 6 Homo sapiens 0-5 10571654-5 1999 Results from lung cancer patients and PAH-exposed coke oven workers correlated CYP1A1-GSTM1 genotype combinations with BPDE-DNA adduct levels. p-Aminohippuric Acid 38-41 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 79-85 10571654-5 1999 Results from lung cancer patients and PAH-exposed coke oven workers correlated CYP1A1-GSTM1 genotype combinations with BPDE-DNA adduct levels. p-Aminohippuric Acid 38-41 glutathione S-transferase mu 1 Homo sapiens 86-91 9867872-4 1999 This mutual repression may provide an underlying mechanism for many hitherto poorly understood PAH-induced toxic responses, and may also provide a mechanistic explanation for alteration of xenobiotic metabolism by cytokines and compounds that regulate NF-kappaB. p-Aminohippuric Acid 95-98 nuclear factor kappa B subunit 1 Homo sapiens 252-261 9827570-2 1998 Uptake of p-aminohippurate (PAH) by the oocytes expressing OAT1 was markedly inhibited by glutarate, alpha-ketoglutarate and probenecid, moderately inhibited by folate and methotrexate, but not inhibited by taurocholate or tetraethylammonium. p-Aminohippuric Acid 10-26 solute carrier family 22 member 6 Rattus norvegicus 59-63 9827570-2 1998 Uptake of p-aminohippurate (PAH) by the oocytes expressing OAT1 was markedly inhibited by glutarate, alpha-ketoglutarate and probenecid, moderately inhibited by folate and methotrexate, but not inhibited by taurocholate or tetraethylammonium. p-Aminohippuric Acid 28-31 solute carrier family 22 member 6 Rattus norvegicus 59-63 9827570-5 1998 OAT1-mediated PAH uptake was markedly inhibited by phorbol 12-myristate 13-acetate (PMA), phorbol 12,13-dibutyrate and mezerein, but not by 4alpha-phorbol 12,13-didecanoate. p-Aminohippuric Acid 14-17 solute carrier family 22 member 6 Rattus norvegicus 0-4 9788587-5 1998 Incubation with Cd2+ induced a bell-shaped concentration response curve with a 2-fold increase of the PAH transport at a Cd2+ concentration of 10(-6) M. Since Cd2+ has been described to activate protein kinase C (PKC), the effects of the PKC inhibitor staurosporine were also tested. p-Aminohippuric Acid 102-105 T-cell surface antigen CD2 Oryctolagus cuniculus 16-19 9792817-6 1998 CT1 did not transport typical substrates for either organic anion or organic cation transporters, such as p-aminohippurate and tetraethylammonium. p-Aminohippuric Acid 106-122 solute carrier family 22 member 5 Rattus norvegicus 0-3 9824245-1 1998 A sensitive and specific high-performance liquid chromatographic assay was developed for the simultaneous determination of p-aminohippuric acid (PAH), acetyl-p-aminohippuric acid (aPAH), and iothalamate in human plasma and urine. p-Aminohippuric Acid 123-143 phenylalanine hydroxylase Homo sapiens 145-148 9788587-5 1998 Incubation with Cd2+ induced a bell-shaped concentration response curve with a 2-fold increase of the PAH transport at a Cd2+ concentration of 10(-6) M. Since Cd2+ has been described to activate protein kinase C (PKC), the effects of the PKC inhibitor staurosporine were also tested. p-Aminohippuric Acid 102-105 T-cell surface antigen CD2 Oryctolagus cuniculus 121-124 9788587-5 1998 Incubation with Cd2+ induced a bell-shaped concentration response curve with a 2-fold increase of the PAH transport at a Cd2+ concentration of 10(-6) M. Since Cd2+ has been described to activate protein kinase C (PKC), the effects of the PKC inhibitor staurosporine were also tested. p-Aminohippuric Acid 102-105 T-cell surface antigen CD2 Oryctolagus cuniculus 121-124 9788587-10 1998 Thus, the observed effects of Cd2+ may be due to an enhanced transport of p-aminohippuric acid by stimulation of exchange of PAH with alpha-ketoglutarate. p-Aminohippuric Acid 74-94 T-cell surface antigen CD2 Oryctolagus cuniculus 30-33 9788587-10 1998 Thus, the observed effects of Cd2+ may be due to an enhanced transport of p-aminohippuric acid by stimulation of exchange of PAH with alpha-ketoglutarate. p-Aminohippuric Acid 125-128 T-cell surface antigen CD2 Oryctolagus cuniculus 30-33 9448059-7 1997 The N-acetyltransferase activity does not seem to notably affect PAH clearances, although NAc-PAH represents 10.2+/-2.7% of PAH excreted unchanged in 12 healthy subjects. p-Aminohippuric Acid 94-97 synuclein alpha Homo sapiens 90-93 9744534-5 1998 The relationships in human placenta between DNA damage, CYP1A1 activity and genotype have not been well characterized and may be relevant to risks from transplacental PAH exposure. p-Aminohippuric Acid 167-170 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 56-62 9744534-9 1998 Placental PAH-DNA adduct levels were significantly higher in infants with the CYP1A1 MspI restriction site compared with infants without the restriction site (P < 0.01), implicating a genetic factor in inter-individual variation in DNA damage in human placenta. p-Aminohippuric Acid 10-13 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 78-84 9737239-9 1998 Staining for MIB-1 was greater in atrophic (27.5 cells/1000 cells) than in benign glands (3.5 cells/1000 cells), greater in PAH than in simple atrophy (p = 0.0015), and greater with acute (p = 0.05) but not chronic inflammation. p-Aminohippuric Acid 124-127 MIB E3 ubiquitin protein ligase 1 Homo sapiens 13-18 9711266-9 1998 When confounding factors associated with PAH exposure were taken into account a statistically significant effect of CYP1A1 exon 7 polymorphism on DNA adduct levels was found (p = 0.012 in mononuclear WBCs, p = 0.043 in granulocytes). p-Aminohippuric Acid 41-44 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 116-122 9574462-5 1998 Treatment with IGF-I (60 mg/kg twice daily sc) for 31 days resulted in a 14% and 18% increase in the inulin and PAH clearances respectively (n = 6 patients). p-Aminohippuric Acid 112-115 insulin like growth factor 1 Homo sapiens 15-20 9448059-13 1997 In conclusion, HPLC not only enables the simultaneous quantitation of PAH and NAc-PAH, but may also provide more accurate and precise PAH clearance measurements. p-Aminohippuric Acid 82-85 synuclein alpha Homo sapiens 78-81 9374486-5 1997 ROAT1-mediated transport of 50 mu M [3H]PAH was independent of imposed changes in membrane potential. p-Aminohippuric Acid 40-43 solute carrier family 22 member 6 Rattus norvegicus 0-5 9399971-2 1997 PAH was eliminated from the ipsilateral cerebrum extensively with an apparent efflux rate constant of 0.0587 (min-1) after microinjection into a cerebral cortex region termed Par2. p-Aminohippuric Acid 0-3 CD59 molecule (CD59 blood group) Homo sapiens 110-115 9399971-2 1997 PAH was eliminated from the ipsilateral cerebrum extensively with an apparent efflux rate constant of 0.0587 (min-1) after microinjection into a cerebral cortex region termed Par2. p-Aminohippuric Acid 0-3 F2R like trypsin receptor 1 Homo sapiens 175-179 9374486-9 1997 Finally, ROAT1-mediated PAH transport was saturable, with an estimated Km of 70 mu M. Each of these properties is identical to those previously described for the basolateral alpha-ketoglutarate/PAH exchanger in isolated membrane vesicles or intact renal tubules. p-Aminohippuric Acid 24-27 solute carrier family 22 member 6 Rattus norvegicus 9-14 9374486-9 1997 Finally, ROAT1-mediated PAH transport was saturable, with an estimated Km of 70 mu M. Each of these properties is identical to those previously described for the basolateral alpha-ketoglutarate/PAH exchanger in isolated membrane vesicles or intact renal tubules. p-Aminohippuric Acid 194-197 solute carrier family 22 member 6 Rattus norvegicus 9-14 9374830-0 1997 Inhibition of PAH transport by parathyroid hormone in OK cells: involvement of protein kinase C pathway. p-Aminohippuric Acid 14-17 parathyroid hormone Homo sapiens 31-50 9374830-3 1997 PTH inhibited the transcellular transport of PAH from the basal to the apical side, as well as the accumulation of PAH in OK cells. p-Aminohippuric Acid 115-118 parathyroid hormone Homo sapiens 0-3 9374830-1 1997 We have previously shown that the p-aminohippurate (PAH) transport system in OK kidney epithelial cell line is under the regulatory control of protein kinase C. Parathyroid hormone (PTH) could activate protein kinase C, as well as protein kinase A, in OK cells. p-Aminohippuric Acid 34-50 parathyroid hormone Homo sapiens 161-180 9374830-4 1997 Basolateral PAH uptake was inhibited by PTH in a dose- and time-dependent manner. p-Aminohippuric Acid 12-15 parathyroid hormone Homo sapiens 40-43 9374830-1 1997 We have previously shown that the p-aminohippurate (PAH) transport system in OK kidney epithelial cell line is under the regulatory control of protein kinase C. Parathyroid hormone (PTH) could activate protein kinase C, as well as protein kinase A, in OK cells. p-Aminohippuric Acid 34-50 parathyroid hormone Homo sapiens 182-185 9374830-6 1997 The PTH-induced inhibition of the accumulation of PAH was blocked by a protein kinase C inhibitor staurosporine. p-Aminohippuric Acid 50-53 parathyroid hormone Homo sapiens 4-7 9374830-1 1997 We have previously shown that the p-aminohippurate (PAH) transport system in OK kidney epithelial cell line is under the regulatory control of protein kinase C. Parathyroid hormone (PTH) could activate protein kinase C, as well as protein kinase A, in OK cells. p-Aminohippuric Acid 52-55 parathyroid hormone Homo sapiens 161-180 9374830-7 1997 These results suggest that PTH inhibits the PAH transport in OK cells and that the messenger system mediated by protein kinase C, not protein kinase A, plays an important role in the regulation of PAH transport by PTH. p-Aminohippuric Acid 44-47 parathyroid hormone Homo sapiens 27-30 9374830-7 1997 These results suggest that PTH inhibits the PAH transport in OK cells and that the messenger system mediated by protein kinase C, not protein kinase A, plays an important role in the regulation of PAH transport by PTH. p-Aminohippuric Acid 197-200 parathyroid hormone Homo sapiens 214-217 9374830-1 1997 We have previously shown that the p-aminohippurate (PAH) transport system in OK kidney epithelial cell line is under the regulatory control of protein kinase C. Parathyroid hormone (PTH) could activate protein kinase C, as well as protein kinase A, in OK cells. p-Aminohippuric Acid 52-55 parathyroid hormone Homo sapiens 182-185 9374830-2 1997 In the present study, the effect of PTH on PAH transport was studied in OK cells. p-Aminohippuric Acid 43-46 parathyroid hormone Homo sapiens 36-39 9374830-3 1997 PTH inhibited the transcellular transport of PAH from the basal to the apical side, as well as the accumulation of PAH in OK cells. p-Aminohippuric Acid 45-48 parathyroid hormone Homo sapiens 0-3 8891493-6 1996 The resting RBF was also measured simultaneously by both RA and the para-aminohippuric acid (PAH) clearance method (CPAH). p-Aminohippuric Acid 93-96 carboxypeptidase A6 Homo sapiens 116-120 10072805-7 1997 CONCLUSIONS: Pulmonary ACE participated in the modulation of changes of SMC phenotype and collagen metabolism during hypoxic PAH. p-Aminohippuric Acid 125-128 angiotensin I converting enzyme Homo sapiens 23-26 9208060-2 1997 Studies were undertaken to examine whether extracts of polyaromatic hydrocarbons (PAH) from diesel exhaust particles (DEP) (PAH-DEP) acted as mucosal adjuvants to help initiate or enhance immunoglobulin E (IgE) production in response to common inhaled allergens. p-Aminohippuric Acid 82-85 immunoglobulin heavy constant epsilon Homo sapiens 206-209 9228667-7 1997 Surprisingly, in tumors of stage pT1 PAH uptake is lowest. p-Aminohippuric Acid 37-40 zinc finger protein 77 Homo sapiens 33-36 9228014-4 1997 When expressed in Xenopus laevis oocytes, OAT1 mediated sodium-independent para-aminohippurate (PAH) uptake (Km = 14.3 +/- 2.9 microM). p-Aminohippuric Acid 75-94 ornithine aminotransferase L homeolog Xenopus laevis 42-46 9228014-4 1997 When expressed in Xenopus laevis oocytes, OAT1 mediated sodium-independent para-aminohippurate (PAH) uptake (Km = 14.3 +/- 2.9 microM). p-Aminohippuric Acid 96-99 ornithine aminotransferase L homeolog Xenopus laevis 42-46 9228014-5 1997 The uptake rate of PAH was increased by the outwardly directed dicarboxylate gradient, consisting with the idea that OAT1 is an organic anion/dicarboxylate exchanger. p-Aminohippuric Acid 19-22 solute carrier family 22 member 6 Rattus norvegicus 117-121 8702823-4 1996 By use of stable LLC-PK1 cell monolayers transfected with the rat OAT-K1 cDNA, the transporter was suggested to mediate basolateral uptake of methotrexate, an anionic anticancer drug, but not taurocholate, p-aminohippurate, prostaglandin E2, and leukotriene C4. p-Aminohippuric Acid 206-222 solute carrier organic anion transporter family member 1A3 Rattus norvegicus 66-72 7733310-6 1995 For PAH, the difference between ModCIM and StM clearance was related to the average PAH clearance by ModCIM and StM (r = 0.78). p-Aminohippuric Acid 4-7 sulfotransferase family 1A member 3 Homo sapiens 112-115 7666479-13 1995 Separately, the presence of PAH-dGMP adducts was associated with the GSTM1 null genotype (absence of the gene) (odds ratio = 8.6; 95% confidence interval = 1.03-100). p-Aminohippuric Acid 28-31 glutathione S-transferase mu 1 Homo sapiens 69-74 7666479-15 1995 CYP2D6 and CYP2E1 genotypes are associated with higher 7-methyl-dGMP levels, while the GSTM1 null genotype is associated with higher numbers of PAH-dGMP adducts. p-Aminohippuric Acid 144-147 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 0-6 7666479-15 1995 CYP2D6 and CYP2E1 genotypes are associated with higher 7-methyl-dGMP levels, while the GSTM1 null genotype is associated with higher numbers of PAH-dGMP adducts. p-Aminohippuric Acid 144-147 glutathione S-transferase mu 1 Homo sapiens 87-92 7733310-6 1995 For PAH, the difference between ModCIM and StM clearance was related to the average PAH clearance by ModCIM and StM (r = 0.78). p-Aminohippuric Acid 4-7 sulfotransferase family 1A member 3 Homo sapiens 43-46 7562483-2 1995 PAH uptake by OK cells from the basal side was inhibited by beta-lactam antibiotics such as benzylpenicillin (PCG) and cefazolin. p-Aminohippuric Acid 0-3 psoriasis susceptibility 1 candidate 2 Rattus norvegicus 110-113 7562483-3 1995 The inhibition of PAH uptake by PCG was competitive and the Ki value was calculated as 108.8 microM. p-Aminohippuric Acid 18-21 psoriasis susceptibility 1 candidate 2 Rattus norvegicus 32-35 7562483-4 1995 Transcellular transport of PCG across OK cell monolayers occurred unidirectionally from the basal to apical side, and transcellular transport and basolateral uptake were inhibited by PAH, probenecid and beta-lactam antibiotics. p-Aminohippuric Acid 183-186 psoriasis susceptibility 1 candidate 2 Rattus norvegicus 27-30 7733310-6 1995 For PAH, the difference between ModCIM and StM clearance was related to the average PAH clearance by ModCIM and StM (r = 0.78). p-Aminohippuric Acid 84-87 sulfotransferase family 1A member 3 Homo sapiens 43-46 7733310-6 1995 For PAH, the difference between ModCIM and StM clearance was related to the average PAH clearance by ModCIM and StM (r = 0.78). p-Aminohippuric Acid 84-87 sulfotransferase family 1A member 3 Homo sapiens 112-115 8128938-3 1994 The renal clearance (CLR) and plasma clearance (CLP) of PAH after constant infusion were 623.7 +/- 62.9 and 869.0 +/- 58.8 mL/min/1.73 m2, respectively. p-Aminohippuric Acid 56-59 calmodulin like 3 Homo sapiens 48-51 7598497-2 1995 Binding of polycyclic or halogenated aromatic hydrocarbon (PAH and HAH) ligand causes release of AHR, which then associates with the AHR nuclear translocator protein (ARNT) to generate the heterodimeric "transformed" AHRC. p-Aminohippuric Acid 59-62 aryl hydrocarbon receptor Homo sapiens 97-100 7598497-2 1995 Binding of polycyclic or halogenated aromatic hydrocarbon (PAH and HAH) ligand causes release of AHR, which then associates with the AHR nuclear translocator protein (ARNT) to generate the heterodimeric "transformed" AHRC. p-Aminohippuric Acid 59-62 aryl hydrocarbon receptor nuclear translocator Homo sapiens 133-165 7598497-2 1995 Binding of polycyclic or halogenated aromatic hydrocarbon (PAH and HAH) ligand causes release of AHR, which then associates with the AHR nuclear translocator protein (ARNT) to generate the heterodimeric "transformed" AHRC. p-Aminohippuric Acid 59-62 aryl hydrocarbon receptor nuclear translocator Homo sapiens 167-171 7529782-3 1995 Interleukin-4 plus CD40 monoclonal antibody-stimulated IgE production was enhanced 20% to 360% by the addition of PAH-DEP over a period of 10 to 14 days. p-Aminohippuric Acid 114-117 interleukin 4 Homo sapiens 0-13 7529782-3 1995 Interleukin-4 plus CD40 monoclonal antibody-stimulated IgE production was enhanced 20% to 360% by the addition of PAH-DEP over a period of 10 to 14 days. p-Aminohippuric Acid 114-117 CD40 molecule Homo sapiens 19-23 7734807-6 1994 Over 3 years of GH treatment, cross-sectional analysis demonstrated an overall increment in median PAH of 1.2 SDS. p-Aminohippuric Acid 99-102 growth hormone 1 Homo sapiens 16-18 7734807-7 1994 There was a positive correlation between gain in PAH and the GH dose (n = 202, r = 0.18, p < 0.01) during the first year. p-Aminohippuric Acid 49-52 growth hormone 1 Homo sapiens 61-63 8079350-8 1994 The ability of B[e]P to induce CYP1A1 promoter-reporter gene activity and EROD activity in WT and CI cells suggested a role for the 4S PAH-binding protein in the induction of CYP1A1. p-Aminohippuric Acid 135-138 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 175-181 8175974-2 1994 Compared to placebo, BNP induced significant increases in effective renal plasma flow (para-aminohippurate clearance), glomerular filtration rate (creatinine clearance), urine flow rate, and sodium excretion without affecting blood pressure, heart rate, cardiac output (echocardiographic method), peripheral vascular resistance, PRA, plasma aldosterone, or plasma norepinephrine to any significant extent. p-Aminohippuric Acid 87-106 natriuretic peptide B Homo sapiens 21-24 7787142-8 1995 Insulin infusion caused a significant 13% increase in RPF and lithium clearance in control subjects, and a positive Spearman rank correlation (Rs = 0.41; P < 0.05) was observed between the changes in p-aminohippurate and lithium clearances during insulin infusion in the combined patient group, suggesting that impaired renal vasodilation may contribute to abnormal proximal tubular sodium handling and sodium retention. p-Aminohippuric Acid 203-219 insulin Homo sapiens 0-7 7787142-8 1995 Insulin infusion caused a significant 13% increase in RPF and lithium clearance in control subjects, and a positive Spearman rank correlation (Rs = 0.41; P < 0.05) was observed between the changes in p-aminohippurate and lithium clearances during insulin infusion in the combined patient group, suggesting that impaired renal vasodilation may contribute to abnormal proximal tubular sodium handling and sodium retention. p-Aminohippuric Acid 203-219 insulin Homo sapiens 250-257 8128938-7 1994 The CLP of PAH after IV bolus injection was significantly lower than after IV infusion when men and women were analyzed together (P < 0.05). p-Aminohippuric Acid 11-14 calmodulin like 3 Homo sapiens 4-7 8498545-7 1993 Administration of rhIGF-I increased levels of circulating IGF-I, inulin clearances, PAH clearances, and kidney size in each of the four patients receiving the growth factor. p-Aminohippuric Acid 84-87 insulin like growth factor 1 Homo sapiens 20-25 7971604-4 1994 Methods for assessment of the affinity of AHR protein to PAH which make it possible to assess human susceptibility to carcinogens have been reviewed. p-Aminohippuric Acid 57-60 aryl hydrocarbon receptor Homo sapiens 42-45 8318526-2 1993 When, however, the oocytes were injected with mRNA from rat kidney cortex, an expressed p-aminohippuric acid (PAH) uptake was seen which differed from the endogenous transporter. p-Aminohippuric Acid 88-108 phenylalanine hydroxylase Rattus norvegicus 110-113 8403212-8 1993 Because the CD-1 preweanling mouse responded to the weak lung tumorigen FA, it is a viable, limited-term bioassay for measuring tumorigenicity of PAH and combustion emissions. p-Aminohippuric Acid 146-149 CD1 antigen complex Mus musculus 12-16 8107182-5 1993 Using PAH clearance and blood pressure measurements a significant decrease in RVR was found (from 0.32 +/- 0.17 to 0.20 +/- 0.07 mm Hg x min/ml, P < 0.05) after administration of the vasodilatory drug nifedipine. p-Aminohippuric Acid 6-9 nuclear receptor subfamily 1 group D member 2 Homo sapiens 78-81 8437119-6 1993 The pEC50 values of the agonists and the pA2 and pAh values of the antagonists correlated strongly with pKD values at the 5-HT1C binding site. p-Aminohippuric Acid 49-52 5-hydroxytryptamine receptor 2C Rattus norvegicus 122-128 8441414-5 1993 The predicted amino acid sequence of the SIN3 protein contains four copies of a paired amphipathic helix (PAH) motif, similar to motifs found in HLH (helix-loop-helix) and TPR (tetratricopeptide repeat) proteins, and these motifs are proposed to be involved in protein-protein interactions. p-Aminohippuric Acid 106-109 transcriptional regulator SIN3 Saccharomyces cerevisiae S288C 41-45 8441414-7 1993 Additionally, the C-terminal region of the SIN3 protein is sufficient for repression activity in a LexA-SIN3 fusion, and deletion of a PAH motif in this region inactivates this repression activity. p-Aminohippuric Acid 135-138 transcriptional regulator SIN3 Saccharomyces cerevisiae S288C 43-47 14621721-2 1992 In this study RVR was calculated from renal blood flow (RBF), measured by the clearance of para-aminohippurate (PAH), and mean arterial pressure (MAP). p-Aminohippuric Acid 91-110 nuclear receptor subfamily 1 group D member 2 Homo sapiens 14-17 1376785-2 1992 Net regional endothelin-1 balance was calculated from the respective arteriovenous differences in plasma concentrations and the corresponding plasma flow, the latter being determined by para-aminohippurate or indocyanine-green dye using appropriate catheter techniques. p-Aminohippuric Acid 186-205 endothelin 1 Homo sapiens 13-25 14621721-2 1992 In this study RVR was calculated from renal blood flow (RBF), measured by the clearance of para-aminohippurate (PAH), and mean arterial pressure (MAP). p-Aminohippuric Acid 112-115 nuclear receptor subfamily 1 group D member 2 Homo sapiens 14-17 2081597-7 1990 Additionally, the results predict that ALDH2 is distal to PAH and IFNG on HSA 12, the type II keratin gene complex will reside between q11 and q21 of HSA 12, A2M will map to MMU 6, and LALBA and GLI will map to MMU 15. p-Aminohippuric Acid 58-61 aldehyde dehydrogenase 2 family member Homo sapiens 39-44 1777587-8 1991 This dose of L-NMMA had minimal effects on renal hemodynamics in the normotensive and hypertensive animals, except for those receiving angiotensin II where it led to substantial reductions of inulin and para-aminohippurate clearance. p-Aminohippuric Acid 208-222 angiotensinogen Rattus norvegicus 135-149 1789949-4 1991 PAH clearance increased 26 +/- 13 mL/min/1.73 m2 on the HS/HC diet but only 10 +/- 17 mL/min/1.73 m2 on HS/LC (P = .05 between groups). p-Aminohippuric Acid 0-3 CD59 molecule (CD59 blood group) Homo sapiens 37-42 2006152-1 1991 A missense mutation has been identified in the human phenylalanine hydroxylase [PAH; phenylalanine 4-monooxygenase; L-phenylalanine, tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating), EC 1.14.16.1] gene in a Chinese patient with classic phenylketonuria (PKU). p-Aminohippuric Acid 80-83 phenylalanine hydroxylase Homo sapiens 53-78 2006152-1 1991 A missense mutation has been identified in the human phenylalanine hydroxylase [PAH; phenylalanine 4-monooxygenase; L-phenylalanine, tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating), EC 1.14.16.1] gene in a Chinese patient with classic phenylketonuria (PKU). p-Aminohippuric Acid 80-83 phenylalanine hydroxylase Homo sapiens 85-114 2006152-1 1991 A missense mutation has been identified in the human phenylalanine hydroxylase [PAH; phenylalanine 4-monooxygenase; L-phenylalanine, tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating), EC 1.14.16.1] gene in a Chinese patient with classic phenylketonuria (PKU). p-Aminohippuric Acid 80-83 thioredoxin reductase 1 Homo sapiens 160-174 1836548-7 1991 Para-aminohippurate clearance (CPAH) increased from 256.4 +/- 21.5 to 291.5 +/- 26.3 ml/min (P less than 0.05), renal vascular resistance was reduced by 21.5% (P less than 0.01) and inulin clearance (CIn) was unchanged. p-Aminohippuric Acid 0-19 pyridoxal phosphatase Homo sapiens 200-203 1740166-3 1992 The turnover rates of DA in the hypothalamus were inversely correlated with the serum PRL levels at the D surge when a significant increase in serum PRL was accompanied by not only a marked decrease in turnover rates of DA in the PAH, but also a slight decrease in turnover rates of the amine in the MPH. p-Aminohippuric Acid 230-233 prolactin Rattus norvegicus 86-89 1832351-4 1991 There was a large dose-dependent fall in effective renal plasma flow (p-aminohippurate clearance) during angiotensin II infusion which was of similar magnitude in both groups (diabetic; 694(46) to 521(21) ml min-1 1.73-m-2; control 665(41) to 498(30) ml min-1 1.73-m-2). p-Aminohippuric Acid 70-86 angiotensinogen Homo sapiens 105-119 1820863-1 1991 The influence of probenecid on p-amino hippurate (PAH) kinetics was investigated in rat. p-Aminohippuric Acid 31-48 phenylalanine hydroxylase Rattus norvegicus 50-53 1658670-8 1991 Clearances of In and PAH were significantly impaired during the administration of CSA. p-Aminohippuric Acid 21-24 ERCC excision repair 8, CSA ubiquitin ligase complex subunit Homo sapiens 82-85 2240230-2 1990 Administration of either bGH (100-200 micrograms/day) or hIGF-I (200 micrograms/day) to rats with normal renal mass increased inulin and p-aminohippurate clearances compared with those measured in animals that received vehicle. p-Aminohippuric Acid 139-153 insulin like growth factor 1 Homo sapiens 57-63 1976527-2 1990 resulted in significant increases in paraaminohippuric acid (PAH) clearance in both four control dogs and four dogs with chronic renal failure. p-Aminohippuric Acid 37-59 phenylalanine hydroxylase Canis lupus familiaris 61-64 34947629-0 2021 Swelling Effects on the Conductivity of Graphene/PSS/PAH Composites. p-Aminohippuric Acid 53-56 PSS Homo sapiens 49-52 2097281-7 1990 Since the increase of cytochrome P-450 may influence on elimination of xenobiotics we have determined affect PAH on their blood level after i.v. p-Aminohippuric Acid 109-112 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 22-38 2295839-7 1990 These observations support the interpretations that a) differentiated keratinocytes have a higher capacity in the metabolic activation of PAH than do germinative cells, although both types of cell are susceptible to induction of cytochrome P-450 by exposure to BA, and b) the cytochrome P-450 induced by exposure of epidermis to benz(a)anthracene in vivo exhibits some differences from the one induced upon exposure of keratinocytes to this procarcinogen in vitro. p-Aminohippuric Acid 138-141 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 276-292 2274750-7 1990 During the highest angiotensin II dose, the 51Cr-EDTA and PAH clearance decreased 14 +/- 15 and 157 +/- 118 ml/min in the diabetics and 14 +/- 15 and 146 +/- 109 in the controls respectively. p-Aminohippuric Acid 58-61 angiotensinogen Homo sapiens 19-33 22988478-9 2012 Among all the 63 CHMs, formulae Gui Zhi Fu Ling Wan (GZ) and Chia Wei Hsiao Yao San (CW) exhibited significant inhibitions on hOAT1-mediated [(3)H]-PAH uptake in vitro and PAH clearance and net secretion in vivo. p-Aminohippuric Acid 148-151 solute carrier family 22 member 6 Homo sapiens 126-131 22988478-9 2012 Among all the 63 CHMs, formulae Gui Zhi Fu Ling Wan (GZ) and Chia Wei Hsiao Yao San (CW) exhibited significant inhibitions on hOAT1-mediated [(3)H]-PAH uptake in vitro and PAH clearance and net secretion in vivo. p-Aminohippuric Acid 172-175 solute carrier family 22 member 6 Homo sapiens 126-131 2361386-2 1990 Para-aminohippurate extraction coefficients were decreased, supporting the need for renal vein sampling to determine CPAH in sepsis. p-Aminohippuric Acid 0-19 carboxypeptidase A6 Homo sapiens 117-121 2328452-9 1990 Angiotensin II reduced [14C]p-aminohippuric acid clearance by about 32% (1.42 +/- 0.18 to 0.97 +/- 0.07 mL.min-1.100 g-1, p less than 0.05). p-Aminohippuric Acid 30-48 angiotensinogen Rattus norvegicus 0-14 34947629-3 2021 Herein, we report successful swelling of a graphene/PSS/PAH composite in a vapor atmosphere, and the relation with the mass fraction of water is uncovered. p-Aminohippuric Acid 56-59 PSS Homo sapiens 52-55 34947629-10 2021 Moreover, molecular dynamics simulations confirmed that a microphase separation occurred when the fraction reached an extreme value owing to the dominated interaction between PSS and PAH. p-Aminohippuric Acid 183-186 PSS Homo sapiens 175-178 34793329-12 2021 Consistent with the results in the VHD patients, we observed decreased BMPR2 and increased fibrosis in the lung of a PAH model mouse. p-Aminohippuric Acid 117-120 bone morphogenetic protein receptor type 2 Homo sapiens 71-76 34737192-0 2021 Gas exchange: the neglected piece in the PAH puzzle. p-Aminohippuric Acid 41-44 gastrin Homo sapiens 0-3 35508593-6 2022 Additionally, a relationship was derived between the estimated glomerular filtration rate and the reduction in OAT1/3-mediated secretion of drugs based on the renal extraction ratios of -aminohippuric acid in patients with varying degrees of renal impairment. p-Aminohippuric Acid 187-206 solute carrier family 22 member 6 Homo sapiens 111-117 34350280-8 2021 One-year survival rates were 75, 82 and 83% in patients with CTD-PAH with ILD, CTD-PAH without ILD and IPAH, respectively. p-Aminohippuric Acid 65-68 CTD Homo sapiens 61-64 34350280-8 2021 One-year survival rates were 75, 82 and 83% in patients with CTD-PAH with ILD, CTD-PAH without ILD and IPAH, respectively. p-Aminohippuric Acid 83-86 CTD Homo sapiens 79-82 34350280-10 2021 Corresponding percentages for CTD-PAH with ILD, CTD-PAH without ILD and IPAH patients were: 0, 26, 67% (p=0.008); 0, 19, 39% (p=0.004); and 0, 16, 29% (p=0.001), respectively. p-Aminohippuric Acid 34-37 CTD Homo sapiens 30-33 34350280-10 2021 Corresponding percentages for CTD-PAH with ILD, CTD-PAH without ILD and IPAH patients were: 0, 26, 67% (p=0.008); 0, 19, 39% (p=0.004); and 0, 16, 29% (p=0.001), respectively. p-Aminohippuric Acid 52-55 CTD Homo sapiens 48-51 34754216-11 2021 NLRP3 inflammasome inhibition ameliorated LPS-induced changes in the immune microenvironment in the right heart and right ventricular dysfunction in rats with PAH. p-Aminohippuric Acid 159-162 NLR family, pyrin domain containing 3 Rattus norvegicus 0-5 34566676-9 2021 Interaction effects between age and %PAH on inhibition showed that at a younger age, males with a higher %PAH had a lower chance of performing well on inhibition, whereas at later ages, males with a higher %PAH had a higher chance to have a good inhibition performance. p-Aminohippuric Acid 106-109 renin binding protein Homo sapiens 28-31 34353949-7 2021 Treatment with GalNAc-HULC mimics reduced excessive Phe in Pair -/- and Pah R408W/R408W mice and improved the Phe tolerance of these mice. p-Aminohippuric Acid 72-75 hepatocellular carcinoma up-regulated long non-coding RNA Homo sapiens 22-26 34350280-3 2021 This retrospective analysis included incident patients with CTD-PAH (n=197, of which 64 had interstitial lung disease, ILD) or IPAH (n=305) enrolled in the Swedish PAH Register (SPAHR) 2008-2019. p-Aminohippuric Acid 64-67 CTD Homo sapiens 60-63 35486615-9 2022 The presence of reads for biphenyl degradation, dioxin degradation, PAH degradation pathways can be further correlated with the presence of PCB and PAH as detected in the MGB-2 and MGB-3 samples. p-Aminohippuric Acid 68-71 secretoglobin family 2A member 1 Homo sapiens 171-176 35486615-9 2022 The presence of reads for biphenyl degradation, dioxin degradation, PAH degradation pathways can be further correlated with the presence of PCB and PAH as detected in the MGB-2 and MGB-3 samples. p-Aminohippuric Acid 148-151 secretoglobin family 2A member 1 Homo sapiens 171-176 35378899-9 2022 Through connectivity map, we also identified eight compounds that may be used as targeted therapeutic agents for ACBD4 gene in HBV-related HCC; these compounds were scopoletin, alfaxalone, bephenium hydroxynaphthoate, apramycin, 4,5-dianilinophthalimide, DL-thiorphan, aminohippuric acid and quinidine. p-Aminohippuric Acid 269-287 acyl-CoA binding domain containing 4 Homo sapiens 113-118 35528545-7 2022 Results: Among all considered exposures and outcomes, we found one CpG site (cg27510182) on gene (DAB1) that potentially mediates the effect of exposure to PAH on CBCL social problems at children aged 7. p-Aminohippuric Acid 156-159 DAB adaptor protein 1 Homo sapiens 98-102 34809917-3 2022 Eisenmenger syndrome is the most severe phenotype of PAH-CHD and is characterized by severe elevation in pulmonary vascular resistance, with shunt reversal causing hypoxemia and central cyanosis. p-Aminohippuric Acid 53-56 choline dehydrogenase Homo sapiens 57-60 35138553-5 2022 Natural ligninolytic enzymes such as MnP, LiP, laccase, peroxidases, and polysaccharide and protein degradative enzymes are found to be highly efficient for PAH degradation and antifouling respectively. p-Aminohippuric Acid 157-160 SMG1 nonsense mediated mRNA decay associated PI3K related kinase Homo sapiens 42-45 2622761-16 1989 Hydrophobicity also renders oligopeptides, as angiotensin II, inhibitory against PAH transport. p-Aminohippuric Acid 81-84 angiotensinogen Rattus norvegicus 46-60 35005565-4 2022 Furthermore, TP53 mutation was more prevalent in smokers, and TP53-mutated tumor harbored more Massilia, as well as Acidovorax that was also capable of degrading PAH. p-Aminohippuric Acid 162-165 tumor protein p53 Homo sapiens 13-17 35005565-4 2022 Furthermore, TP53 mutation was more prevalent in smokers, and TP53-mutated tumor harbored more Massilia, as well as Acidovorax that was also capable of degrading PAH. p-Aminohippuric Acid 162-165 tumor protein p53 Homo sapiens 62-66 2675639-8 1989 Organic anion (p-aminohippurate; PAH) uptake is driven by exchange for certain divalent organic anions, e.g., glutarate and alpha-ketoglutarate. p-Aminohippuric Acid 15-31 phenylalanine hydroxylase Homo sapiens 33-36 2898749-9 1988 PAH stimulated luminal ammoniagenesis was associated with an acceleration of renal glutamine extraction and a steeper blood to urine glutamine diffusion gradient; acivicin blocked this response consistent with PAH secretion coupled to activation of intraluminal gamma-GT and glutamine hydrolysis. p-Aminohippuric Acid 0-3 gamma-glutamyltransferase 1 Rattus norvegicus 262-270 2746999-5 1989 (3) Para amino hippurate clearance correlated with total kallikrein excretion in normal subjects and, with active kallikrein excretion and active-to-total kallikrein ratio in both normal subjects and diabetics, but not with total kallikrein excretion in diabetics. p-Aminohippuric Acid 4-24 kallikrein related peptidase 4 Homo sapiens 57-67 2746999-5 1989 (3) Para amino hippurate clearance correlated with total kallikrein excretion in normal subjects and, with active kallikrein excretion and active-to-total kallikrein ratio in both normal subjects and diabetics, but not with total kallikrein excretion in diabetics. p-Aminohippuric Acid 4-24 kallikrein related peptidase 4 Homo sapiens 114-124 2746999-5 1989 (3) Para amino hippurate clearance correlated with total kallikrein excretion in normal subjects and, with active kallikrein excretion and active-to-total kallikrein ratio in both normal subjects and diabetics, but not with total kallikrein excretion in diabetics. p-Aminohippuric Acid 4-24 kallikrein related peptidase 4 Homo sapiens 114-124 2746999-5 1989 (3) Para amino hippurate clearance correlated with total kallikrein excretion in normal subjects and, with active kallikrein excretion and active-to-total kallikrein ratio in both normal subjects and diabetics, but not with total kallikrein excretion in diabetics. p-Aminohippuric Acid 4-24 kallikrein related peptidase 4 Homo sapiens 114-124 3177651-1 1988 p-Aminohippuric acid (PAH) transport by basolateral membrane (BLM) vesicles isolated from rat renal cortex was stimulated very little by a Na+ gradient (out greater than in). p-Aminohippuric Acid 0-20 phenylalanine hydroxylase Rattus norvegicus 22-25 2706091-6 1989 The para-amino hippurate clearance (CPAH) was decreased in EH. p-Aminohippuric Acid 4-24 carboxypeptidase A6 Homo sapiens 36-40 2967139-5 1988 Intravenous infusion of ANP doubled p-aminohippurate clearance and inulin clearance and elicited massive natriuresis in the hydronephrotic kidney, while in the contralateral kidney these clearance values were decreased and there was a lack of natriuresis. p-Aminohippuric Acid 36-52 natriuretic peptide A Rattus norvegicus 24-27 2896014-7 1988 Mean steady-state fenoldopam plasma concentrations were related to mean PAH clearance based on an Emax model (r = 0.996) with an Emax of 1350 ml min-1 and an EC50 of 6.2 ng ml-1. p-Aminohippuric Acid 72-75 CD59 molecule (CD59 blood group) Homo sapiens 145-150 3105866-5 1987 The ability of the rat MEC to bind relatively higher levels of DMBA than B(a)P to nuclear DNA, and the reversed pattern in human MEC, was found at all incubation times tested between 6 and 48 h. Culture density was found to exert a greater effect on the levels of PAH-DNA binding in rat than in human cells, but in neither case did it affect the ratio of DMBA to B(a)P binding within a species. p-Aminohippuric Acid 264-267 C-C motif chemokine ligand 28 Homo sapiens 23-26 2891856-8 1988 The increase of ochratoxin A exposure from zero through 0.2 ppm to 1 ppm, which resulted in dose-dependent activity decrease of PEPCK and gamma-glutamyl transpeptidase, was accompanied by dose-dependent decrease of renal function, as measured by a reduction of maximal tubular excretion of para-aminohippurate per clearance of inulin (TmPAH/CIn) and an increase in glucose excretion. p-Aminohippuric Acid 290-309 phosphoenolpyruvate carboxykinase 2, mitochondrial Homo sapiens 128-133 3576631-6 1987 Urinary activity of N-acetyl-beta-D-glucosaminidase was increased at the higher dose of styrene during 0-24 and 24-48 h. The capacity of renal cortical slices to accumulate p-aminohippurate was significantly reduced 48 h after the exposure to any dose of styrene. p-Aminohippuric Acid 173-189 O-GlcNAcase Rattus norvegicus 20-51 3393258-4 1988 The PAH clearance (CPAH) was decreased in essential hypertensives. p-Aminohippuric Acid 4-7 carboxypeptidase A6 Homo sapiens 19-23 3443952-8 1987 Rats pre-treated with indomethacin to inhibit prostaglandin synthesis showed a decrease in PAH clearance during the infusion of vasopressin at a dose of 30 pmol h-1 100 g body weight-1, and this suggests that the renal vasoconstrictor actions of vasopressin are attenuated by dilator prostaglandins. p-Aminohippuric Acid 91-94 arginine vasopressin Rattus norvegicus 128-139 3443952-8 1987 Rats pre-treated with indomethacin to inhibit prostaglandin synthesis showed a decrease in PAH clearance during the infusion of vasopressin at a dose of 30 pmol h-1 100 g body weight-1, and this suggests that the renal vasoconstrictor actions of vasopressin are attenuated by dilator prostaglandins. p-Aminohippuric Acid 91-94 arginine vasopressin Rattus norvegicus 246-257 3105866-6 1987 C2SO4 gradient separation of nuclear macromolecules from PAH-treated MEC revealed that the relative DNA binding levels of DMBA and B(a)P did not correlate with relative levels of nuclear protein binding. p-Aminohippuric Acid 57-60 C-C motif chemokine ligand 28 Homo sapiens 69-72 2944353-9 1986 All natriuretic doses of hANP increased PAH clearance (at constant blood pressure), but some did so without measurably affecting creatinine clearance. p-Aminohippuric Acid 40-43 natriuretic peptide A Homo sapiens 25-29 3040585-1 1987 The influence of the major histocompatibility complex (H-2 in mouse) on induction of cytochrome P-450-dependent monooxygenase (P1-450) by the prototype polyaromatic hydrocarbon (PAH), beta-naphthoflavone, was investigated in C57BL/10 Sn (B10) recombinant congenic mice. p-Aminohippuric Acid 178-181 histocompatibility-2, MHC Mus musculus 55-58 3040585-1 1987 The influence of the major histocompatibility complex (H-2 in mouse) on induction of cytochrome P-450-dependent monooxygenase (P1-450) by the prototype polyaromatic hydrocarbon (PAH), beta-naphthoflavone, was investigated in C57BL/10 Sn (B10) recombinant congenic mice. p-Aminohippuric Acid 178-181 granzyme C Mus musculus 238-241 3040585-4 1987 The lower PAH responsiveness in B10.A and B10.A(5R) correlated with their lower Ah-receptor levels while that in B10 appeared to reflect a K-A region influence on PAH responsiveness that was not due to changed Ah-receptor levels. p-Aminohippuric Acid 10-13 granzyme C Mus musculus 32-35 3040585-4 1987 The lower PAH responsiveness in B10.A and B10.A(5R) correlated with their lower Ah-receptor levels while that in B10 appeared to reflect a K-A region influence on PAH responsiveness that was not due to changed Ah-receptor levels. p-Aminohippuric Acid 10-13 granzyme C Mus musculus 42-45 3040585-4 1987 The lower PAH responsiveness in B10.A and B10.A(5R) correlated with their lower Ah-receptor levels while that in B10 appeared to reflect a K-A region influence on PAH responsiveness that was not due to changed Ah-receptor levels. p-Aminohippuric Acid 10-13 aryl-hydrocarbon receptor Mus musculus 80-91 3040585-4 1987 The lower PAH responsiveness in B10.A and B10.A(5R) correlated with their lower Ah-receptor levels while that in B10 appeared to reflect a K-A region influence on PAH responsiveness that was not due to changed Ah-receptor levels. p-Aminohippuric Acid 10-13 granzyme C Mus musculus 42-45 3040585-5 1987 Thus, we conclude that more than one H-2 locus may influence PAH responsiveness, and by different mechanisms. p-Aminohippuric Acid 61-64 histocompatibility-2, MHC Mus musculus 37-40 2820951-5 1987 pAHF3 contained the entire coding sequence of pHP3, but nucleotide sequences for the N-terminal region of pHP3 protein (from the 2nd to the 3rd amino acid) were deleted in pAH delta N3. p-Aminohippuric Acid 0-3 cytochrome P450 2C14 Oryctolagus cuniculus 46-50 2435656-6 1987 The pulse rate did not change, but renal blood flow (p-aminohippurate clearance) increased (from 902 +/- 78 to 1108 +/- 130 ml/min/1.73 m2; p less than 0.05). p-Aminohippuric Acid 53-69 CD59 molecule (CD59 blood group) Homo sapiens 127-132 2947474-2 1986 Throughout the infusion in intact animals, ANF significantly increased glomerular filtration rate (GFR) (clearance of inulin) (P less than 0.001), and, to a lesser extent, total renal plasma flow (RPF) [clearance of p-aminohippurate (PAH)] (P less than 0.02) and filtration fraction (P less than 0.02). p-Aminohippuric Acid 216-232 natriuretic peptide A Homo sapiens 43-46 2947474-2 1986 Throughout the infusion in intact animals, ANF significantly increased glomerular filtration rate (GFR) (clearance of inulin) (P less than 0.001), and, to a lesser extent, total renal plasma flow (RPF) [clearance of p-aminohippurate (PAH)] (P less than 0.02) and filtration fraction (P less than 0.02). p-Aminohippuric Acid 234-237 natriuretic peptide A Homo sapiens 43-46 3752141-4 1986 Renal and adrenal responsiveness to angiotensin II was assessed by measurement of para-aminohippurate clearance and plasma aldosterone prior to and during the infusion of 3 ng/kg per minute of angiotensin II, to identify the non-modulator group (n = 32). p-Aminohippuric Acid 82-101 angiotensinogen Homo sapiens 36-50 3900132-7 1985 In contrast, the urinary excretion of 6-keto-PGF1 alpha showed a significant linear correlation with both CCr and para-aminohippurate clearance rate (CPAH). p-Aminohippuric Acid 114-133 carboxypeptidase A6 Homo sapiens 150-154 2997418-6 1985 This varied slightly among groups but was significantly reduced by probenecid blockade and para-aminohippuric acid (PAH) competition to 4.08 +/- 0.55 (p less than 0.005) and 2.39 +/- 0.14 (p less than 0.005), respectively. p-Aminohippuric Acid 91-114 phenylalanine hydroxylase Rattus norvegicus 116-119 3005043-3 1986 The presence of tris(picolinato)manganese(II) [MnII(PA)2(PAH)(H2O)], a model complex for mitochondrial superoxide dismutase, (i) efficiently catalyzes the disproportionation of O2.-, (ii) precludes the formation HO2., and thereby (iii) prevents hydrogen abstraction from allylic and thiol groups. p-Aminohippuric Acid 57-60 heme oxygenase 2 Homo sapiens 212-215 6362960-5 1984 ANG II (3 pmol kg-1 min-1) also produced a significantly (P less than 0.03) greater reduction in PAH clearance after (-194 +/- 40 ml/min) compared with before (-104 +/- 15 ml/min) captopril. p-Aminohippuric Acid 97-100 angiotensinogen Homo sapiens 0-6 6362960-5 1984 ANG II (3 pmol kg-1 min-1) also produced a significantly (P less than 0.03) greater reduction in PAH clearance after (-194 +/- 40 ml/min) compared with before (-104 +/- 15 ml/min) captopril. p-Aminohippuric Acid 97-100 CD59 molecule (CD59 blood group) Homo sapiens 20-25 6309884-6 1983 Blood pressure and PAH responses to infused AII in sodium-replete subjects were not significantly modified by MK421 treatment, confirming that the drug effect was specific. p-Aminohippuric Acid 19-22 angiotensinogen Homo sapiens 44-47 6309884-8 1983 Thus, sodium-modulated changes in PAH and blood pressure responsiveness to infused AII depend on circulating AII levels. p-Aminohippuric Acid 34-37 angiotensinogen Homo sapiens 109-112 3972499-1 1985 In vitro accumulation of radioactive para-aminohippuric acid (3H-PAH) and rubidium (86Rb+) by the anterior uvea, ciliary processes, and the choroid plexus was evaluated in tissues from newborn and various aged rabbits. p-Aminohippuric Acid 37-60 phenylalanine-4-hydroxylase Oryctolagus cuniculus 65-68 4074410-1 1985 The effect of torasemide, a new diuretic, on p-aminohippuric acid (PAH) transport (TPAH) was studied using renal clearance and micropuncture techniques in anaesthetized rats. p-Aminohippuric Acid 45-65 phenylalanine hydroxylase Rattus norvegicus 67-70 6482164-2 1984 AII decreases para-aminohippurate clearance (63%) more than glomerular filtration rate (GFR) (42%), resulting in an increased filtration fraction (54%). p-Aminohippuric Acid 14-33 angiotensinogen Rattus norvegicus 0-3