PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
5059190-4	1972	On the basis of these findings along with the clinical manifestations of Tay-Sachs disease with visceral involvement (hepatosplenomegaly) and demonstration of total deficiency of both A and B components of beta-N-acetylhexosaminidase activity, this glycosphingolipidosis is the same as two previously reported cases of G(M2) gangliosidosis with globoside accumulation and total beta-N-acetylhexosaminidase deficiency.	Globosides	345-354	O-GlcNAcase	Homo sapiens	206-233
31373757-8	2019	On the other hand, OGT silencing perturbs biosynthesis of glycosphingolipids resulting in a decrease in gangliosides and an increase in globosides.	Globosides	136-146	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	19-22
13162652-2	1953	Globoside, as the agglutinogen of the ABO system on erythrocytes.	Globosides	0-9	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	38-41
24992926-5	2014	Owing to the fact that alphaGalA-deficient humans and mice accumulate the same glycosphingolipids (i.e. globosides, galabiosylceramide and isoglobosides), alphaGalA-deficient mice were crossed with mice deficient in enzymes synthesizing these classes of glycosphingolipids (i.e. globotrihexosylceramide and isoglobotrihexosylceramide synthase, respectively).	Globosides	104-114	galactosidase, alpha	Mus musculus	23-32
29892643-4	2018	Isolated an IgG3 (kappa) monoclonal antibody (mAb PA4.2) from the immunized mouse showed high specificity and reactivity against globoside.	Globosides	129-138	Immunoglobulin heavy constant gamma 3	Mus musculus	12-16
26055721-0	2015	Identification of the Molecular and Genetic Basis of PX2, a Glycosphingolipid Blood Group Antigen Lacking on Globoside-deficient Erythrocytes.	Globosides	109-118	pannexin 2	Homo sapiens	53-56
19651642-3	2009	He also isolated a glycosphingolipid, globoside, from human erythrocytes and demonstrated for the first time that ABO blood group antigens are glycosphingolipids in the erythrocytes.	Globosides	38-47	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	114-129
24046919-1	2013	The P blood group antigen of the GLOB system is a glycolipid structure, also known as globoside, on the red blood cells (RBCs) of almost all individuals worldwide.	Globosides	86-95	beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)	Homo sapiens	33-37
22875802-2	2012	Isoglobotrihexosylceramide (iGb3) has been implicated as this endogenous selecting ligand and recently suggested to control overstimulation and deletion of iNKT cells in alpha-galactosidase A-deficient (alphaGalA(-/-)) mice (human Fabry disease), which accumulate isoglobosides and globosides.	Globosides	267-277	alpha 1,3-galactosyltransferase 2 (isoglobotriaosylceramide synthase)	Mus musculus	28-32
22875802-7	2012	Finally, we show that correction of globoside storage in alphaGalA(-/-) mice by crossing them with Gb3S(-/-) normalizes iNKT cell frequencies and dendritic cell (DC) function.	Globosides	36-45	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	99-103
22542783-0	2012	Globoside promotes activation of ERK by interaction with the epidermal growth factor receptor.	Globosides	0-9	mitogen-activated protein kinase 1	Homo sapiens	33-36
22542783-0	2012	Globoside promotes activation of ERK by interaction with the epidermal growth factor receptor.	Globosides	0-9	epidermal growth factor receptor	Homo sapiens	61-93
12175970-3	2002	The cellular receptor necessary for B19 infectivity is globoside.	Globosides	55-64	eva-1 homolog C	Homo sapiens	36-39
16917549-7	2006	In SCC, an increase of 2 to 3 times in the amounts of CDH, CTH, Globoside, and GM3 was observed in comparison to normal mucosa.	Globosides	64-73	serpin family B member 3	Homo sapiens	3-6
15739820-11	2004	The results illustrated B19"s ability to bind in a specific manner to globoside-containing villous trophoblast cells.	Globosides	70-79	eva-1 homolog C	Homo sapiens	24-27
8755503-5	1996	The glycolipid receptor molecules bind into the depressions on the 3-fold axes of the B19:globoside complex.	Globosides	90-99	eva-1 homolog C	Homo sapiens	86-89
11481344-4	2001	Using selective endocytic inhibitors and dominant negative constructs of dynamin and epidermal growth factor receptor pathway substrate clone 15, we found that analogues of lactosylceramide and globoside were internalized almost exclusively by a clathrin-independent ("caveolar-like") mechanism, whereas an analogue of sphingomyelin was taken up approximately equally by clathrin-dependent and -independent pathways.	Globosides	194-203	epidermal growth factor receptor	Homo sapiens	85-117
10358066-5	1999	The enzyme expressed in COS-7 cells transferred a glucuronic acid (GlcA) not only to asialo-orosomucoid, a glycoprotein bearing terminal N-acetyllactosamine structure, but also to paragloboside (lacto-N-neotetraosylceramide), a precursor of the HNK-1 epitope on glycolipids.	Globosides	195-223	beta-1,3-glucuronyltransferase 1	Rattus norvegicus	245-250
9972868-5	1999	However, treatment of A beta-activated THP-1 cells with GM1 and several other complex gangliosides, but not hematosides and neutral glycosphingolipids such as asialo-GM1 (GA1), lactosylceramide, and globoside, significantly decreased the cytokine release.	Globosides	199-208	amyloid beta precursor protein	Homo sapiens	22-28
9972868-5	1999	However, treatment of A beta-activated THP-1 cells with GM1 and several other complex gangliosides, but not hematosides and neutral glycosphingolipids such as asialo-GM1 (GA1), lactosylceramide, and globoside, significantly decreased the cytokine release.	Globosides	199-208	GLI family zinc finger 2	Homo sapiens	39-44
9446552-0	1998	Globoside-dependent adhesion of human embryonal carcinoma cells, based on carbohydrate-carbohydrate interaction, initiates signal transduction and induces enhanced activity of transcription factors AP1 and CREB.	Globosides	0-9	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	198-201
9446552-0	1998	Globoside-dependent adhesion of human embryonal carcinoma cells, based on carbohydrate-carbohydrate interaction, initiates signal transduction and induces enhanced activity of transcription factors AP1 and CREB.	Globosides	0-9	cAMP responsive element binding protein 1	Homo sapiens	206-210
9103463-7	1997	3) Inclusion of sCD14 is absolutely necessary to observe LBP-dependent neutralization of LPS by sphingomyelin, globoside, and phosphatidylserine.	Globosides	111-120	lipopolysaccharide binding protein	Homo sapiens	57-60
9950151-4	1999	The presence of globoside on the protective trophoblast layer of the villi provides a potential pathway whereby B19 may be transmitted from an infected mother to the fetus.	Globosides	16-25	eva-1 homolog C	Homo sapiens	112-115
8991535-2	1996	The basis of this erythroid tropism is the tissue distribution of the B19 cellular receptor, globoside (blood group P antigen).	Globosides	93-102	hormonally up-regulated Neu-associated kinase	Homo sapiens	70-73
1628323-1	1992	We reported recently that two glycosphingolipids (GSLs), globoside (Gb4) and ganglioside GM3, colocalized with vimentin intermediate filaments of human umbilical vein endothelial cells.	Globosides	57-66	vimentin	Homo sapiens	111-119
1530650-2	1992	When the binding study was performed on TLC plates, SP-D bound exclusively to GlcCer, whereas it failed to bind to GalCer, GM1, GM2, asialo-GM1, asialo-GM2, sulfatide, Forssman antigen, ceramide dihexoside, ceramide trihexoside, globoside, paragloboside or ceramide.	Globosides	229-238	surfactant protein D	Rattus norvegicus	52-56
8563519-2	1995	The basis of this erythroid tropism is the tissue distribution of the B19 cellular receptor, globoside (blood group P antigen).	Globosides	93-102	hormonally up-regulated Neu-associated kinase	Homo sapiens	70-73
1899071-4	1991	Immunofluorescence staining of fixed, permeabilized HUVECs showed colocalization of globoside and GM3 with vimentin but not with tubulin or actin.	Globosides	84-93	vimentin	Homo sapiens	107-115
1884198-4	1991	Antibody CC1 reacts with a globoside-like glycolipid which contains a terminal N-acetylgalactosamine residue.	Globosides	27-36	Cardiac cell morphology QTL 1	Rattus norvegicus	9-12
2021640-5	1991	In the case of globoside, where the glycolipid headgroup is equivalent to that of GlcCer extended by three sugar residues, values for the quadrupolar splittings associated with the acyl chain C2-position were very close to those obtained for Gal- and GlcCer.	Globosides	15-24	galanin and GMAP prepropeptide	Homo sapiens	242-257
7451473-4	1981	The incubation of platelets with thrombin resulted in a 50% reduction in the labeling of both trihexosylceramide and globoside and a 100% increase in labeling of hematoside on the platelet surface.	Globosides	117-126	coagulation factor II, thrombin	Homo sapiens	33-41
2110799-4	1990	In particular, surface expression of the major neutral GSL, globoside, decreased three- to fourfold as measured both by galactose oxidase labeling and by binding of the anti-globoside monoclonal antibody 9G7.	Globosides	60-69	cathepsin A	Homo sapiens	55-58
2110799-5	1990	IFN-gamma did not significantly alter the total cell content of globoside, as measured by metabolic labeling, but rather altered the ratio of accessible cell surface to intracellular globoside.	Globosides	183-192	interferon gamma	Homo sapiens	0-9
34502101-8	2021	Importantly, we found increased levels of ceramide phosphate, globoside Gb3, and ganglioside GD3 in the exosomes derived from the transformed cells.	Globosides	62-71	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	72-75
35151689-9	2022	In addition, we observed differences in O- and GSL-glycosylation profiles after TGF-beta treatment, including lower levels of sialylated Tn antigen and neo-expression of globosides.	Globosides	170-180	transforming growth factor alpha	Homo sapiens	80-88
3203695-5	1988	Soluble sialoglycoproteins and membrane-incorporated glycophorin A stimulated the oxidation of globoside-containing vesicles, whereas membrane-bound GD1a ganglioside had no effect on globoside oxidation.	Globosides	95-104	glycophorin A (MNS blood group)	Homo sapiens	53-66
3514610-3	1986	PA1 cells contain globotriaosylceramide, sialosylgangliotriaosylceramide, sialylated and nonsialylated lacto-N-neotetraosylceramide, and the following glycolipids with a blood group type 1 sequence: (formula; see text) The two former glycolipids, lacto-N-tetraosylceramide and sialosyllacto-N-tetraosylceramide, reacted with monoclonal antibodies, K21 and K4, respectively.	Globosides	103-131	PAXIP1 associated glutamate rich protein 1	Homo sapiens	0-3
3514610-3	1986	PA1 cells contain globotriaosylceramide, sialosylgangliotriaosylceramide, sialylated and nonsialylated lacto-N-neotetraosylceramide, and the following glycolipids with a blood group type 1 sequence: (formula; see text) The two former glycolipids, lacto-N-tetraosylceramide and sialosyllacto-N-tetraosylceramide, reacted with monoclonal antibodies, K21 and K4, respectively.	Globosides	247-272	PAXIP1 associated glutamate rich protein 1	Homo sapiens	0-3
2409238-5	1985	IFN also caused increases in the amounts of non-hydroxy fatty acid cerebroside, ceramide trihexoside, asialo-GM1, asialo-GM2 and globoside.	Globosides	129-138	interferon alpha 1	Homo sapiens	0-3
6412685-4	1983	The specificity of the enzyme towards bovine corneal keratan sulphate, milk oligosaccharides and the glycolipids lacto-N-neotetraosylceramide and lacto-N-tetraosylceramide closely resembled that of the endo-beta-galactosidase isolated from Escherichia freundii.	Globosides	113-141	galactosidase beta 1	Bos taurus	207-225
6412685-4	1983	The specificity of the enzyme towards bovine corneal keratan sulphate, milk oligosaccharides and the glycolipids lacto-N-neotetraosylceramide and lacto-N-tetraosylceramide closely resembled that of the endo-beta-galactosidase isolated from Escherichia freundii.	Globosides	146-171	galactosidase beta 1	Bos taurus	207-225
6125477-4	1982	However, coating of neuraminidase-treated p erythrocytes with globoside rendered such erythrocytes agglutinable by the P fimbriae.	Globosides	62-71	neuraminidase 1	Homo sapiens	20-33
2907082-5	1987	In a whole bacteria ELISA it was shown that the MAbs, which recognized Pap, F7(2) and F11 fimbriae, reacted with recombinant strains which did not express Pap or F11 fimbriae, but still expressed the globoside binding properties.	Globosides	200-209	regenerating family member 3 alpha	Homo sapiens	71-74
2907082-7	1987	In a haemagglutination and adherence assay it was shown that only the MAbs which recognized the Pap, F7(2) and F11 fimbriae inhibited the adhesive properties of the globoside binding recombinant strain.	Globosides	165-174	regenerating family member 3 alpha	Homo sapiens	96-99
6773959-3	1980	When the radioactive Forssman glycolipid from the mixed substrates was hydrolyzed with alpha-N-acetylgalactosaminidase, the ratio of 14C-labeled globoside to the liberated N-acetyl[14C]galactosamine was 0.38, indicating that Hex3Cer could serve as a substrate.	Globosides	145-154	alpha-N-acetylgalactosaminidase	Mesocricetus auratus	87-118
850070-1	1977	Paragloboside (lacto-N-neotetraosyl ceramide) is a biosynthetic precursor of the ABH and P1 blood group glycosphingolipids and of one class of gangliosides.	Globosides	15-44	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	81-84
6444774-4	1980	It can be shown that the activator protein for the enzymic degradation of ganglioside GM2 has a very strong preference for hex A over hex B; it also acts on glycolipid GA2 and, to a lesser extent, on kidney globoside.	Globosides	207-216	hexosaminidase subunit alpha	Homo sapiens	123-128