PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 16917549-7 2006 In SCC, an increase of 2 to 3 times in the amounts of CDH, CTH, Globoside, and GM3 was observed in comparison to normal mucosa. Globosides 64-73 serpin family B member 3 Homo sapiens 3-6 11481344-4 2001 Using selective endocytic inhibitors and dominant negative constructs of dynamin and epidermal growth factor receptor pathway substrate clone 15, we found that analogues of lactosylceramide and globoside were internalized almost exclusively by a clathrin-independent ("caveolar-like") mechanism, whereas an analogue of sphingomyelin was taken up approximately equally by clathrin-dependent and -independent pathways. Globosides 194-203 epidermal growth factor receptor Homo sapiens 85-117 12175970-3 2002 The cellular receptor necessary for B19 infectivity is globoside. Globosides 55-64 eva-1 homolog C Homo sapiens 36-39 15739820-11 2004 The results illustrated B19"s ability to bind in a specific manner to globoside-containing villous trophoblast cells. Globosides 70-79 eva-1 homolog C Homo sapiens 24-27 10358066-5 1999 The enzyme expressed in COS-7 cells transferred a glucuronic acid (GlcA) not only to asialo-orosomucoid, a glycoprotein bearing terminal N-acetyllactosamine structure, but also to paragloboside (lacto-N-neotetraosylceramide), a precursor of the HNK-1 epitope on glycolipids. Globosides 195-223 beta-1,3-glucuronyltransferase 1 Rattus norvegicus 245-250 9950151-4 1999 The presence of globoside on the protective trophoblast layer of the villi provides a potential pathway whereby B19 may be transmitted from an infected mother to the fetus. Globosides 16-25 eva-1 homolog C Homo sapiens 112-115 9972868-5 1999 However, treatment of A beta-activated THP-1 cells with GM1 and several other complex gangliosides, but not hematosides and neutral glycosphingolipids such as asialo-GM1 (GA1), lactosylceramide, and globoside, significantly decreased the cytokine release. Globosides 199-208 amyloid beta precursor protein Homo sapiens 22-28 9972868-5 1999 However, treatment of A beta-activated THP-1 cells with GM1 and several other complex gangliosides, but not hematosides and neutral glycosphingolipids such as asialo-GM1 (GA1), lactosylceramide, and globoside, significantly decreased the cytokine release. Globosides 199-208 GLI family zinc finger 2 Homo sapiens 39-44 9446552-0 1998 Globoside-dependent adhesion of human embryonal carcinoma cells, based on carbohydrate-carbohydrate interaction, initiates signal transduction and induces enhanced activity of transcription factors AP1 and CREB. Globosides 0-9 JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 198-201 9446552-0 1998 Globoside-dependent adhesion of human embryonal carcinoma cells, based on carbohydrate-carbohydrate interaction, initiates signal transduction and induces enhanced activity of transcription factors AP1 and CREB. Globosides 0-9 cAMP responsive element binding protein 1 Homo sapiens 206-210 8755503-5 1996 The glycolipid receptor molecules bind into the depressions on the 3-fold axes of the B19:globoside complex. Globosides 90-99 eva-1 homolog C Homo sapiens 86-89 9103463-7 1997 3) Inclusion of sCD14 is absolutely necessary to observe LBP-dependent neutralization of LPS by sphingomyelin, globoside, and phosphatidylserine. Globosides 111-120 lipopolysaccharide binding protein Homo sapiens 57-60 1884198-4 1991 Antibody CC1 reacts with a globoside-like glycolipid which contains a terminal N-acetylgalactosamine residue. Globosides 27-36 Cardiac cell morphology QTL 1 Rattus norvegicus 9-12 8563519-2 1995 The basis of this erythroid tropism is the tissue distribution of the B19 cellular receptor, globoside (blood group P antigen). Globosides 93-102 hormonally up-regulated Neu-associated kinase Homo sapiens 70-73 1530650-2 1992 When the binding study was performed on TLC plates, SP-D bound exclusively to GlcCer, whereas it failed to bind to GalCer, GM1, GM2, asialo-GM1, asialo-GM2, sulfatide, Forssman antigen, ceramide dihexoside, ceramide trihexoside, globoside, paragloboside or ceramide. Globosides 229-238 surfactant protein D Rattus norvegicus 52-56 8991535-2 1996 The basis of this erythroid tropism is the tissue distribution of the B19 cellular receptor, globoside (blood group P antigen). Globosides 93-102 hormonally up-regulated Neu-associated kinase Homo sapiens 70-73 1628323-1 1992 We reported recently that two glycosphingolipids (GSLs), globoside (Gb4) and ganglioside GM3, colocalized with vimentin intermediate filaments of human umbilical vein endothelial cells. Globosides 57-66 vimentin Homo sapiens 111-119 1899071-4 1991 Immunofluorescence staining of fixed, permeabilized HUVECs showed colocalization of globoside and GM3 with vimentin but not with tubulin or actin. Globosides 84-93 vimentin Homo sapiens 107-115 2021640-5 1991 In the case of globoside, where the glycolipid headgroup is equivalent to that of GlcCer extended by three sugar residues, values for the quadrupolar splittings associated with the acyl chain C2-position were very close to those obtained for Gal- and GlcCer. Globosides 15-24 galanin and GMAP prepropeptide Homo sapiens 242-257 2110799-4 1990 In particular, surface expression of the major neutral GSL, globoside, decreased three- to fourfold as measured both by galactose oxidase labeling and by binding of the anti-globoside monoclonal antibody 9G7. Globosides 60-69 cathepsin A Homo sapiens 55-58 2110799-5 1990 IFN-gamma did not significantly alter the total cell content of globoside, as measured by metabolic labeling, but rather altered the ratio of accessible cell surface to intracellular globoside. Globosides 183-192 interferon gamma Homo sapiens 0-9 2409238-5 1985 IFN also caused increases in the amounts of non-hydroxy fatty acid cerebroside, ceramide trihexoside, asialo-GM1, asialo-GM2 and globoside. Globosides 129-138 interferon alpha 1 Homo sapiens 0-3 35151689-9 2022 In addition, we observed differences in O- and GSL-glycosylation profiles after TGF-beta treatment, including lower levels of sialylated Tn antigen and neo-expression of globosides. Globosides 170-180 transforming growth factor alpha Homo sapiens 80-88 3203695-5 1988 Soluble sialoglycoproteins and membrane-incorporated glycophorin A stimulated the oxidation of globoside-containing vesicles, whereas membrane-bound GD1a ganglioside had no effect on globoside oxidation. Globosides 95-104 glycophorin A (MNS blood group) Homo sapiens 53-66 34502101-8 2021 Importantly, we found increased levels of ceramide phosphate, globoside Gb3, and ganglioside GD3 in the exosomes derived from the transformed cells. Globosides 62-71 alpha 1,4-galactosyltransferase (P blood group) Homo sapiens 72-75 2907082-5 1987 In a whole bacteria ELISA it was shown that the MAbs, which recognized Pap, F7(2) and F11 fimbriae, reacted with recombinant strains which did not express Pap or F11 fimbriae, but still expressed the globoside binding properties. Globosides 200-209 regenerating family member 3 alpha Homo sapiens 71-74 2907082-7 1987 In a haemagglutination and adherence assay it was shown that only the MAbs which recognized the Pap, F7(2) and F11 fimbriae inhibited the adhesive properties of the globoside binding recombinant strain. Globosides 165-174 regenerating family member 3 alpha Homo sapiens 96-99 3514610-3 1986 PA1 cells contain globotriaosylceramide, sialosylgangliotriaosylceramide, sialylated and nonsialylated lacto-N-neotetraosylceramide, and the following glycolipids with a blood group type 1 sequence: (formula; see text) The two former glycolipids, lacto-N-tetraosylceramide and sialosyllacto-N-tetraosylceramide, reacted with monoclonal antibodies, K21 and K4, respectively. Globosides 103-131 PAXIP1 associated glutamate rich protein 1 Homo sapiens 0-3 3514610-3 1986 PA1 cells contain globotriaosylceramide, sialosylgangliotriaosylceramide, sialylated and nonsialylated lacto-N-neotetraosylceramide, and the following glycolipids with a blood group type 1 sequence: (formula; see text) The two former glycolipids, lacto-N-tetraosylceramide and sialosyllacto-N-tetraosylceramide, reacted with monoclonal antibodies, K21 and K4, respectively. Globosides 247-272 PAXIP1 associated glutamate rich protein 1 Homo sapiens 0-3 6125477-4 1982 However, coating of neuraminidase-treated p erythrocytes with globoside rendered such erythrocytes agglutinable by the P fimbriae. Globosides 62-71 neuraminidase 1 Homo sapiens 20-33 6412685-4 1983 The specificity of the enzyme towards bovine corneal keratan sulphate, milk oligosaccharides and the glycolipids lacto-N-neotetraosylceramide and lacto-N-tetraosylceramide closely resembled that of the endo-beta-galactosidase isolated from Escherichia freundii. Globosides 113-141 galactosidase beta 1 Bos taurus 207-225 6412685-4 1983 The specificity of the enzyme towards bovine corneal keratan sulphate, milk oligosaccharides and the glycolipids lacto-N-neotetraosylceramide and lacto-N-tetraosylceramide closely resembled that of the endo-beta-galactosidase isolated from Escherichia freundii. Globosides 146-171 galactosidase beta 1 Bos taurus 207-225 6773959-3 1980 When the radioactive Forssman glycolipid from the mixed substrates was hydrolyzed with alpha-N-acetylgalactosaminidase, the ratio of 14C-labeled globoside to the liberated N-acetyl[14C]galactosamine was 0.38, indicating that Hex3Cer could serve as a substrate. Globosides 145-154 alpha-N-acetylgalactosaminidase Mesocricetus auratus 87-118 7451473-4 1981 The incubation of platelets with thrombin resulted in a 50% reduction in the labeling of both trihexosylceramide and globoside and a 100% increase in labeling of hematoside on the platelet surface. Globosides 117-126 coagulation factor II, thrombin Homo sapiens 33-41 6444774-4 1980 It can be shown that the activator protein for the enzymic degradation of ganglioside GM2 has a very strong preference for hex A over hex B; it also acts on glycolipid GA2 and, to a lesser extent, on kidney globoside. Globosides 207-216 hexosaminidase subunit alpha Homo sapiens 123-128 850070-1 1977 Paragloboside (lacto-N-neotetraosyl ceramide) is a biosynthetic precursor of the ABH and P1 blood group glycosphingolipids and of one class of gangliosides. Globosides 15-44 alkB homolog 1, histone H2A dioxygenase Homo sapiens 81-84 31373757-8 2019 On the other hand, OGT silencing perturbs biosynthesis of glycosphingolipids resulting in a decrease in gangliosides and an increase in globosides. Globosides 136-146 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 19-22 5059190-4 1972 On the basis of these findings along with the clinical manifestations of Tay-Sachs disease with visceral involvement (hepatosplenomegaly) and demonstration of total deficiency of both A and B components of beta-N-acetylhexosaminidase activity, this glycosphingolipidosis is the same as two previously reported cases of G(M2) gangliosidosis with globoside accumulation and total beta-N-acetylhexosaminidase deficiency. Globosides 345-354 O-GlcNAcase Homo sapiens 206-233 13162652-2 1953 Globoside, as the agglutinogen of the ABO system on erythrocytes. Globosides 0-9 ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase Homo sapiens 38-41 24046919-1 2013 The P blood group antigen of the GLOB system is a glycolipid structure, also known as globoside, on the red blood cells (RBCs) of almost all individuals worldwide. Globosides 86-95 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) Homo sapiens 33-37 24992926-5 2014 Owing to the fact that alphaGalA-deficient humans and mice accumulate the same glycosphingolipids (i.e. globosides, galabiosylceramide and isoglobosides), alphaGalA-deficient mice were crossed with mice deficient in enzymes synthesizing these classes of glycosphingolipids (i.e. globotrihexosylceramide and isoglobotrihexosylceramide synthase, respectively). Globosides 104-114 galactosidase, alpha Mus musculus 23-32 29892643-4 2018 Isolated an IgG3 (kappa) monoclonal antibody (mAb PA4.2) from the immunized mouse showed high specificity and reactivity against globoside. Globosides 129-138 Immunoglobulin heavy constant gamma 3 Mus musculus 12-16 26055721-0 2015 Identification of the Molecular and Genetic Basis of PX2, a Glycosphingolipid Blood Group Antigen Lacking on Globoside-deficient Erythrocytes. Globosides 109-118 pannexin 2 Homo sapiens 53-56 19651642-3 2009 He also isolated a glycosphingolipid, globoside, from human erythrocytes and demonstrated for the first time that ABO blood group antigens are glycosphingolipids in the erythrocytes. Globosides 38-47 ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase Homo sapiens 114-129 22875802-2 2012 Isoglobotrihexosylceramide (iGb3) has been implicated as this endogenous selecting ligand and recently suggested to control overstimulation and deletion of iNKT cells in alpha-galactosidase A-deficient (alphaGalA(-/-)) mice (human Fabry disease), which accumulate isoglobosides and globosides. Globosides 267-277 alpha 1,3-galactosyltransferase 2 (isoglobotriaosylceramide synthase) Mus musculus 28-32 22875802-7 2012 Finally, we show that correction of globoside storage in alphaGalA(-/-) mice by crossing them with Gb3S(-/-) normalizes iNKT cell frequencies and dendritic cell (DC) function. Globosides 36-45 alpha 1,4-galactosyltransferase (P blood group) Homo sapiens 99-103 22542783-0 2012 Globoside promotes activation of ERK by interaction with the epidermal growth factor receptor. Globosides 0-9 mitogen-activated protein kinase 1 Homo sapiens 33-36 22542783-0 2012 Globoside promotes activation of ERK by interaction with the epidermal growth factor receptor. Globosides 0-9 epidermal growth factor receptor Homo sapiens 61-93