PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
11007651-2	2000	DHPS is essential for the de novo synthesis of folate in prokaryotes, lower eukaryotes, and in plants, but is absent in mammals.	Folic Acid	47-53	dihydropteroate synthetase	Escherichia coli	0-4
10997917-11	2000	Folates, superoxide ions, and peroxynitrite scavengers restore the NO-generating activity to eNOS, collectively suggesting that cellular redox state plays an important role in HCy-suppressed NO-generating function of this enzyme.	Folic Acid	0-7	nitric oxide synthase 3	Homo sapiens	93-97
10930360-6	2000	Methionine synthase reductase (MTRR) is another enzyme essential for normal folate metabolism.	Folic Acid	76-82	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	0-29
10930360-6	2000	Methionine synthase reductase (MTRR) is another enzyme essential for normal folate metabolism.	Folic Acid	76-82	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	31-35
10980121-5	2000	In folic acid-induced ARF, galectin-3 mRNA was found to be up-regulated at 2 hours after injury and increased levels continued until at least 7 days post-injury.	Folic Acid	3-13	galectin 3	Rattus norvegicus	27-37
10787414-6	2000	These studies, done with N(5)-methyltetrahydrofolate (the predominant folate derivative in blood) and folate as substrates, have shown that RFT-1 functions in a Na(+)- and C1(-)-independent manner.	Folic Acid	46-52	RFT1 homolog	Homo sapiens	140-145
10787414-6	2000	These studies, done with N(5)-methyltetrahydrofolate (the predominant folate derivative in blood) and folate as substrates, have shown that RFT-1 functions in a Na(+)- and C1(-)-independent manner.	Folic Acid	70-76	RFT1 homolog	Homo sapiens	140-145
10955817-2	2000	A valine-to-methionine substitution at amino acid 104 in the reduced folate carrier (RFC1) explains this disparity in drug resistance.	Folic Acid	69-75	replication factor C (activator 1) 1	Mus musculus	85-89
10919749-3	2000	There is also a paucity of prospective evidence concerning the possible associations between cervical cancer and vitamin B12, which shares pathways with folate, and homocysteine, a marker of low B vitamin concentrations.	Folic Acid	153-159	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	121-124
10861758-4	2000	PSM is a glutamate exocarboxypeptidase capable of cleaving the terminal alpha-linked glutamate from the dipeptide N-acetyl-aspartyl-glutamate (NAAG) and the gamma-linked glutamates from folate polyglutamate.	Folic Acid	186-192	folate hydrolase 1	Homo sapiens	0-3
10894832-2	2000	The four most common functional polymorphisms in genes involved in folate/homocysteine metabolism are methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, methionine synthase (MS) A2756G, and cystathionine beta-synthase (CBS) 844ins68.	Folic Acid	67-73	cystathionine beta-synthase	Homo sapiens	201-228
10894832-2	2000	The four most common functional polymorphisms in genes involved in folate/homocysteine metabolism are methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, methionine synthase (MS) A2756G, and cystathionine beta-synthase (CBS) 844ins68.	Folic Acid	67-73	cystathionine beta-synthase	Homo sapiens	230-233
10850963-0	2000	Folic acid reverts dysfunction of endothelial nitric oxide synthase.	Folic Acid	0-10	nitric oxide synthase 3	Homo sapiens	34-67
10825425-1	2000	The reduced folate carrier (RFC1) is a major transporter for both natural reduced folates and antifolate chemotherapeutics.	Folic Acid	12-18	replication factor C (activator 1) 1	Mus musculus	28-32
10825425-1	2000	The reduced folate carrier (RFC1) is a major transporter for both natural reduced folates and antifolate chemotherapeutics.	Folic Acid	82-89	replication factor C (activator 1) 1	Mus musculus	28-32
10833331-0	2000	Polymorphisms in the CBS gene associated with decreased risk of coronary artery disease and increased responsiveness to total homocysteine lowering by folic acid.	Folic Acid	151-161	cystathionine beta-synthase	Homo sapiens	21-24
11498380-3	2000	The target of sulfonamides, and the basis for their selectivity, is the enzyme dihydropteroate synthase (DHPS) in the folic acid pathway.	Folic Acid	118-128	deoxyhypusine synthase	Homo sapiens	79-103
11498380-3	2000	The target of sulfonamides, and the basis for their selectivity, is the enzyme dihydropteroate synthase (DHPS) in the folic acid pathway.	Folic Acid	118-128	deoxyhypusine synthase	Homo sapiens	105-109
10833331-4	2000	We found that two single nucleotide polymorphisms in the cystathionine beta synthase (CBS) gene, 699C --> T and 1080T --> C, are associated with decreased risk of CAD and increased responsiveness to the tHcy lowering effects of folic acid.	Folic Acid	228-238	cystathionine beta-synthase	Homo sapiens	57-84
10833331-4	2000	We found that two single nucleotide polymorphisms in the cystathionine beta synthase (CBS) gene, 699C --> T and 1080T --> C, are associated with decreased risk of CAD and increased responsiveness to the tHcy lowering effects of folic acid.	Folic Acid	228-238	cystathionine beta-synthase	Homo sapiens	86-89
10661482-1	2000	AIMS: To examine the possible relationships between recombinant human erythropoietin (rhEPO) therapy, serum folic acid and homocysteine levels in a cohort of stable, chronically hemodialyzed patients.	Folic Acid	108-118	erythropoietin	Homo sapiens	70-84
10767323-5	2000	NTD risk is reduced in various models by different maternal nutrient supplements, including folic acid ( Pax3, Cart1, Cd mutants), inositol ( ct ) and methionine ( Axd ).	Folic Acid	92-102	paired box 3	Mus musculus	105-109
10661482-11	2000	Significant correlations (ANOVA) were observed between serum erythropoietin and folic acid levels (r = -0.382; p = 0.049), and between folic acid and homocysteine levels (r = -0.560; p = 0.002).	Folic Acid	80-90	erythropoietin	Homo sapiens	61-75
10585460-6	1999	All the mutants, however, were able to bind folate, although with lower affinity than wild-type N(t)-FDH.	Folic Acid	44-50	aldehyde dehydrogenase 1 family member L1	Homo sapiens	96-104
10773664-1	2000	We have identified a new human gene, FTCD, which maps to chromosome 21q22.3 and encodes the enzyme formiminotransferase cyclodeaminase, an intermediate metabolism enzyme that links histidine catabolism to folate metabolism.	Folic Acid	205-211	formimidoyltransferase cyclodeaminase	Homo sapiens	37-41
10773664-1	2000	We have identified a new human gene, FTCD, which maps to chromosome 21q22.3 and encodes the enzyme formiminotransferase cyclodeaminase, an intermediate metabolism enzyme that links histidine catabolism to folate metabolism.	Folic Acid	205-211	formimidoyltransferase cyclodeaminase	Homo sapiens	99-134
10695265-9	2000	Furthermore, VV subjects in the lowest folate quartile exhibited significantly higher mean erythrocyte volumes (MCV) and a tendency towards higher erythrocyte hemoglobin content (MCH) than AA and AV subjects (P = 0.008 and 0.069, respectively).	Folic Acid	39-45	pro-melanin concentrating hormone	Homo sapiens	179-182
10851861-3	2000	In the present study we investigated whether the administration of recombinant human erythropoietin (rHuEpo) recombinant human erythropoietin in combination with iron and folic acid may ameliorate blood indices as an alternative choice to blood transfusion.	Folic Acid	171-181	erythropoietin	Homo sapiens	85-99
10600765-0	1999	Folic acid inhibition of EGFR-mediated proliferation in human colon cancer cell lines.	Folic Acid	0-10	epidermal growth factor receptor	Homo sapiens	25-29
10600765-4	1999	Furthermore, because certain tyrosine kinases, particularly epidermal growth factor receptor (EGFR), play a role in regulating cell proliferation, we also examined the folic acid-induced changes in tyrosine kinase activity and expression of EGFR.	Folic Acid	168-178	epidermal growth factor receptor	Homo sapiens	241-245
10600765-6	1999	Pretreatment of HCT-116 and Caco-2 cell lines with supplemental folic acid (1.25 microg/ml) completely abrogated transforming growth factor-alpha (TGF-alpha)-induced proliferation in both cell lines.	Folic Acid	64-74	tumor necrosis factor	Homo sapiens	113-145
10600765-7	1999	Tyrosine kinase activity and the relative concentration of EGFR were markedly diminished in both cell lines following a 24-h exposure to supplemental folic acid.	Folic Acid	150-160	epidermal growth factor receptor	Homo sapiens	59-63
10600765-8	1999	The folic acid-induced inhibition of EGFR tyrosine kinase activity in colon cancer cell lines was also associated with a concomitant reduction in the relative concentration of the 14-kDa membrane-bound precursor form of TGF-alpha.	Folic Acid	4-14	epidermal growth factor receptor	Homo sapiens	37-41
10535753-1	1999	A phenylalanine substitution for serine in the reduced folate carrier at residue 309 (RFC1-S309F) was identified in a methotrexate (MTX)-resistant cell line selected with 5-formyltetrahydrofolate (5-CHO-THF) as the sole folate source.	Folic Acid	189-195	replication factor C (activator 1) 1	Mus musculus	86-90
10535753-9	1999	This study represents another example of a single mutation in RFC1 that markedly impairs MTX influx but partially preserves transport of reduced folates when cells are selected with 5-CHO-THF as the available folate substrate.	Folic Acid	145-152	replication factor C (activator 1) 1	Mus musculus	62-66
10535753-9	1999	This study represents another example of a single mutation in RFC1 that markedly impairs MTX influx but partially preserves transport of reduced folates when cells are selected with 5-CHO-THF as the available folate substrate.	Folic Acid	145-151	replication factor C (activator 1) 1	Mus musculus	62-66
10535753-10	1999	The data indicate that residues in the predicted eighth transmembrane domain of RFC1 can play an important role in the selectivity of folate binding and the mobility of the carrier-substrate complex.	Folic Acid	134-140	replication factor C (activator 1) 1	Mus musculus	80-84
10697523-2	1999	Thymidylate synthase is inhibited by 5-fluorodeoxyuridine monophosphate, forming an inactive ternary complex with intracellular folate.	Folic Acid	128-134	thymidylate synthetase	Rattus norvegicus	0-20
10697524-1	1999	Thymidylate synthase, which is a key enzyme involved in the de novo pathway for pyrimidine nucleotide synthesis, is inhibited by 5-fluorodeoxyuridine monophosphate, forming an inactive ternary complex with intracellular folate.	Folic Acid	220-226	thymidylate synthetase	Rattus norvegicus	0-20
10697524-4	1999	Thymidylate synthase inhibition was slightly increased as the intracellular folate concentration increased.	Folic Acid	76-82	thymidylate synthetase	Rattus norvegicus	0-20
10697524-5	1999	These results indicate that thymidylate synthase inhibition increases when the intracellular folate is exogenously supplemented and maintained at an adequate concentration.	Folic Acid	93-99	thymidylate synthetase	Rattus norvegicus	28-48
10563782-5	1999	For the G-2 dendrimer with 16 hydrazide groups, an average number of only 12.6 folate residues were attached to each dendrimer.	Folic Acid	79-85	crystallin gamma E, pseudogene	Homo sapiens	8-11
10533864-2	1999	Sulpha resistance in many microorganisms is caused by point mutations in dihydropteroate synthase (DHPS), an enzyme that is essential for folate biosynthesis.	Folic Acid	138-144	deoxyhypusine synthase	Homo sapiens	99-103
10535753-1	1999	A phenylalanine substitution for serine in the reduced folate carrier at residue 309 (RFC1-S309F) was identified in a methotrexate (MTX)-resistant cell line selected with 5-formyltetrahydrofolate (5-CHO-THF) as the sole folate source.	Folic Acid	55-61	replication factor C (activator 1) 1	Mus musculus	86-90
10557004-11	1999	In habitual diets, where folate intake is adequate, lowered vitamin B12 intake from animal foods leads to depleted plasma vitamin B12 concentration with a concomitant increase in homocysteine concentration.	Folic Acid	25-31	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	68-71
10484769-0	1999	Molecular basis for methionine synthase reductase deficiency in patients belonging to the cblE complementation group of disorders in folate/cobalamin metabolism.	Folic Acid	133-139	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	90-94
10484769-1	1999	Methionine synthase reductase (MSR) deficiency is an autosomal recessive disorder of folate/cobalamin metabolism leading to hyperhomocysteinemia, hypo- methioninemia and megaloblastic anemia.	Folic Acid	85-91	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	0-29
10484769-1	1999	Methionine synthase reductase (MSR) deficiency is an autosomal recessive disorder of folate/cobalamin metabolism leading to hyperhomocysteinemia, hypo- methioninemia and megaloblastic anemia.	Folic Acid	85-91	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	31-34
10419687-6	1999	Splotch is an established model of folate-sensitive neural tube defects, and homozygous mutant embryos develop spina bifida and sometimes exencephaly.	Folic Acid	35-41	paired box 3	Mus musculus	0-7
10504494-7	1999	METHODS: The expression pattern of Pax-2 in kidneys after experimentally-induced acute tubular necrosis caused by intraperitoneally injected folic acid in mice was tested by indirect immunofluorescence, Western blotting, reverse transcriptase-polymerase chain reaction, and in situ hybridization analysis.	Folic Acid	141-151	paired box 2	Mus musculus	35-40
10449621-7	1999	Successful rejection was achieved with folate conjugates of Fab or scFv fragments.	Folic Acid	39-45	immunglobulin heavy chain variable region	Homo sapiens	67-71
10527405-0	1999	Treatment of hyperhomocysteinemia with folic acid and vitamins B12 and B6 attenuates thrombin generation.	Folic Acid	39-49	coagulation factor II, thrombin	Homo sapiens	85-93
10527405-13	1999	In subjects with hyperhomocysteinemia a reduction of plasma fasting homocysteine concentration by folic acid and vitamins B12 and B6 administration is associated with attenuation of thrombin generation both in peripheral blood and at sites of hemostatic plug formation.	Folic Acid	98-108	coagulation factor II, thrombin	Homo sapiens	182-190
10449187-0	1999	A method for genotyping murine arylamine N-acetyltransferase type 2 (NAT2): a gene expressed in preimplantation embryonic stem cells encoding an enzyme acetylating the folate catabolite p-aminobenzoylglutamate.	Folic Acid	168-174	N-acetyltransferase 2 (arylamine N-acetyltransferase)	Mus musculus	69-73
10449187-4	1999	Mouse NAT2 and human NAT1 have a widespread tissue distribution and the folate catabolite p-aminobenzoylglutamate (pAB-Glu) has been proposed as a candidate endogenous substrate.	Folic Acid	72-78	N-acetyltransferase 2 (arylamine N-acetyltransferase)	Mus musculus	6-10
10449187-10	1999	Murine NAT2 is likely to be expressed prior to neurulation and this may be important in view of the protective role of folate in neural tube development.	Folic Acid	119-125	N-acetyltransferase 2 (arylamine N-acetyltransferase)	Mus musculus	7-11
10645030-3	1999	OBJECTIVES: The aim of the study was to investigate the influence of erythropoietin treatment during long-term 15 months study on serum vitamin A levels and its protein carriers, prealbumin and retinol-binding protein, on erythrocyte vitamin B1, B2 and B6 and folic acid and on serum or plasma vitamins B12, C and E levels in hemodialyzed patients.	Folic Acid	260-270	erythropoietin	Homo sapiens	69-83
10645030-12	1999	Erythrocyte vitamin B6 and folic acid significantly decreased due to erythropoietin treatment.	Folic Acid	27-37	erythropoietin	Homo sapiens	69-83
10645030-14	1999	CONCLUSIONS: Supplementations of pyridoxine in the dose of 20 mg/day and of folic acid 5 mg/week in hemodialyzed patients during erythropoietin treatment are necessary.	Folic Acid	76-86	erythropoietin	Homo sapiens	129-143
10364640-7	1999	The numbers of APOE4 and tMTHFR alleles correlated significantly with the serum folate levels, however, in opposite directions.	Folic Acid	80-86	apolipoprotein E	Homo sapiens	15-20
10339503-5	1999	Because many antifolates and folic acid-linked chemotherapeutic agents enter malignant cells at least partially via FR endocytosis, it was important to evaluate the ability of FR on CD34(+) cells to bind folic acid (FA).	Folic Acid	204-214	CD34 molecule	Homo sapiens	182-186
10385685-1	1999	Chemical mutagenesis with N-methyl-N-nitrosourea was employed to study the pattern of mutations in the reduced folate carrier (RFC1) that results in transport-related methotrexate resistance and to identify amino acid residues that are critical to carrier structure and/or function.	Folic Acid	111-117	replication factor C (activator 1) 1	Mus musculus	127-131
10334668-12	1999	Low doses (2-3 mg/week) should normally be sufficient to maintain optimal folic acid stores in epoetin-treated patients, although higher doses are necessary for patients with hyperhomocysteinaemia.	Folic Acid	74-84	erythropoietin	Homo sapiens	95-102
10022646-7	1999	Folic acid supplementation had a small, significant protective effect for p53 mutations (RR 0.97, CI 0.94-1.00).	Folic Acid	0-10	tumor protein p53	Homo sapiens	74-77
10022646-8	1999	CONCLUSION: p53 Mutations 1) are associated with, and likely precede, dysplasia and cancer, 2) are associated with cancer-related mortality, and 3) may possibly be prevented by folic acid supplementation.	Folic Acid	177-187	tumor protein p53	Homo sapiens	12-15
10598570-2	1999	Two non-folate-sensitive rare fragile sites (FRA10B and FRA17A) have been previously recorded in normal individuals.	Folic Acid	8-14	fragile site, BrdU type, rare, fra(10)(q25.2)	Homo sapiens	45-51
10598570-2	1999	Two non-folate-sensitive rare fragile sites (FRA10B and FRA17A) have been previously recorded in normal individuals.	Folic Acid	8-14	fragile site, distamycin A type, rare, fra(17)(p12)	Homo sapiens	56-62
10334668-11	1999	Folic acid is supplemented routinely in haemodialysis patients, though evidence that it increases the efficacy of epoetin is limited.	Folic Acid	0-10	erythropoietin	Homo sapiens	114-121
10575307-0	1999	Correction of epoetin-resistant megaloblastic anaemia following vitamin B(12) and folate administration.	Folic Acid	82-88	erythropoietin	Homo sapiens	14-21
10050095-0	1999	Erythropoietin response to folic acid substitution.	Folic Acid	27-37	erythropoietin	Homo sapiens	0-14
9685395-2	1998	Jejunal folylpoly-gamma-glutamate carboxypeptidase hydrolyzes dietary folates prior to their intestinal absorption.	Folic Acid	70-77	folate hydrolase 1	Homo sapiens	8-50
10088035-7	1998	No association, in either population group, was found for CBS, MS and MTHFR, the enzymes most directly associated with the known risk factors in folate metabolism.	Folic Acid	145-151	methylenetetrahydrofolate reductase	Mus musculus	70-75
9625844-6	1998	These results suggest that folate metabolism can affect carcinogenesis through the expression of p16INK4.	Folic Acid	27-33	cyclin dependent kinase inhibitor 2A	Homo sapiens	97-104
10095804-13	1998	In the folate group versus the placebo group serum levels of vitamin B12 increased by 9.9% (P = 0.010) and 9.6% (P = 0.043) while folate levels increased by 96.9 and 89.9% at week 4 and 12, respectively.	Folic Acid	7-13	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	69-72
9641914-2	1998	The deoxyuridine suppression test detects disturbance of folate metabolism in homozygous splotch (Pax3) mouse embryos that are developing NTDs in vitro.	Folic Acid	57-63	paired box 3	Mus musculus	98-102
9551080-1	1998	The Dictyostelium ERK2 protein is transiently activated when cells are treated with the chemotactic agents cAMP or folic acid.	Folic Acid	115-125	mitogen-activated protein kinase 1	Homo sapiens	18-22
9622670-8	1998	Taken together with previous evidence demonstrating their presence in GCP II-expressing tissues, these data suggest that both NAAG and folates are good candidate substrates for GCP II in vivo.	Folic Acid	135-142	golgin B1	Homo sapiens	177-180
9641178-13	1998	A direct association was found between CCK levels and some nutritional markers (albumin, fibronectin, triglycerides, folic acid and nPCR in non diabetic patients).	Folic Acid	117-127	cholecystokinin	Homo sapiens	39-42
9664599-6	1998	Since cobalamin, folate and homocysteine participate in the remethylation of homocysteine, via methyl transfer from 5-methyltetrahydrofolate to B12, to methionine, we compared ratios of these methionine synthase (EC 2.1.1.13)-related intermediates.	Folic Acid	17-23	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	144-147
9525881-10	1998	This represents the first reported RFC1 mutation that confers resistance to MTX due to a markedly impaired influx with relative conservation of reduced folate transport.	Folic Acid	152-158	replication factor C (activator 1) 1	Mus musculus	35-39
9701830-1	1998	Homocysteine is a metabolite of methionine that may be remethylated by enzymes requiring folate and cobalamin (vitamin B12) to again form methionine or catabolized by the pyridoxine (vitamin B6) dependent enzyme, cystathionine beta synthase (CBS) to form cysteine (fig.	Folic Acid	89-95	cystathionine beta-synthase	Homo sapiens	213-240
9528665-0	1998	Effect of folic acid on thymidylate synthase and thymidine kinase in regenerating rat liver after partial hepatectomy.	Folic Acid	10-20	thymidylate synthetase	Rattus norvegicus	24-44
9528665-2	1998	The injection of folic acid inhibited the increases in the activities of thymidylate synthase and thymidine kinase in regenerating rat liver at 24 h after partial hepatectomy, with a concomitant reduction in DNA content.	Folic Acid	17-27	thymidylate synthetase	Rattus norvegicus	73-93
9528665-4	1998	At 48 and 72 h, after partial hepatectomy, the thymidylate synthase activities in the folic acid injected rats increased to about 1.9- and 1.7-fold the corresponding control level, respectively, while thymidine kinase activities were similar to the control.	Folic Acid	86-96	thymidylate synthetase	Rattus norvegicus	47-67
9528665-6	1998	Folic acid suppressed chymotryptic hydrolysis of thymidylate synthase.	Folic Acid	0-10	thymidylate synthetase	Rattus norvegicus	49-69
9528665-7	1998	These suggest that folic acid increases the protein level of thymidylate synthase, at least in part, through protection against proteolysis.	Folic Acid	19-29	thymidylate synthetase	Rattus norvegicus	61-81
9472972-0	1998	Cystathionine-beta-synthase deficiency: detection of heterozygotes by the ratios of homocysteine to cysteine and folate.	Folic Acid	113-119	cystathionine beta-synthase	Homo sapiens	0-27
9446553-0	1998	A single amino acid difference within the folate transporter encoded by the murine RFC-1 gene selectively alters its interaction with folate analogues.	Folic Acid	42-48	replication factor C (activator 1) 1	Mus musculus	83-88
9384610-2	1998	Most patients have a mutation in the 5" untranslated region of the FMR1 gene, consisting of the amplification of a polymorphic (CGG)nrepeat sequence, and cytogenetically express the folate-sensitive fragile site FRAXA in Xq27.3.	Folic Acid	182-188	fragile X messenger ribonucleoprotein 1	Homo sapiens	67-71
9701830-1	1998	Homocysteine is a metabolite of methionine that may be remethylated by enzymes requiring folate and cobalamin (vitamin B12) to again form methionine or catabolized by the pyridoxine (vitamin B6) dependent enzyme, cystathionine beta synthase (CBS) to form cysteine (fig.	Folic Acid	89-95	cystathionine beta-synthase	Homo sapiens	242-245
9278558-0	1997	Compartmentation of folate metabolism in rat pancreas: nitrous oxide inactivation of methionine synthase leads to accumulation of 5-methyltetrahydrofolate in cytosol.	Folic Acid	20-26	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	85-104
9295311-0	1997	Activation of the mitogen-activated protein kinase ERK2 by the chemoattractant folic acid in Dictyostelium.	Folic Acid	79-89	mitogen-activated protein kinase 1	Homo sapiens	51-55
9295311-20	1997	In this study, we show that folic acid activates ERK2 in developmentally regulated manner and is required for ERK2 stimulation of adenylyl cyclase activity.	Folic Acid	28-38	mitogen-activated protein kinase 1	Homo sapiens	49-53
9295311-20	1997	In this study, we show that folic acid activates ERK2 in developmentally regulated manner and is required for ERK2 stimulation of adenylyl cyclase activity.	Folic Acid	28-38	mitogen-activated protein kinase 1	Homo sapiens	110-114
9295311-21	1997	Maximum levels of folate-stimulated ERK2 activity occur in cells from very early in development, prior to aggregation, and again at the tipped aggregate stages, corresponding to the stages in which folate receptors and the coupled Galpha subunit Galpha4 are maximally expressed.	Folic Acid	18-24	mitogen-activated protein kinase 1	Homo sapiens	36-40
9295311-22	1997	During the activation by folic acid, ERK2 is phosphorylated on tyrosine residue(s) and contemporaneously shows a mobility shift on SDS-PAGE.	Folic Acid	25-35	mitogen-activated protein kinase 1	Homo sapiens	37-41
9295311-30	1997	Furthermore, we show that the activation of ERK2 by cAMP is independent of the Galpha4 subunit, while the activation of ERK2 by folate is independent of Galpha2.	Folic Acid	128-134	mitogen-activated protein kinase 1	Homo sapiens	120-124
9261128-0	1997	Impact of overexpression of the reduced folate carrier (RFC1), an anion exchanger, on concentrative transport in murine L1210 leukemia cells.	Folic Acid	40-46	replication factor C (activator 1) 1	Mus musculus	56-60
9261128-1	1997	Transport of reduced folates in murine leukemia cells is mediated by the bidirectional reduced folate carrier (RFC1) and independent unidirectional exit pumps.	Folic Acid	21-28	replication factor C (activator 1) 1	Mus musculus	111-115
9261128-1	1997	Transport of reduced folates in murine leukemia cells is mediated by the bidirectional reduced folate carrier (RFC1) and independent unidirectional exit pumps.	Folic Acid	21-27	replication factor C (activator 1) 1	Mus musculus	111-115
9261128-3	1997	This paper defines the role of high level carrier expression, through transfection with RFC1 cDNA, on concentrative transport of the folate analog, methotrexate (MTX) in murine L1210 leukemia cells.	Folic Acid	133-139	replication factor C (activator 1) 1	Mus musculus	88-92
9261128-10	1997	The data indicate that RFC1 produces a large and near symmetrical increase in the bidirectional fluxes of MTX resulting in only a small increase in the transmembrane chemical gradient at low extracellular folate levels.	Folic Acid	205-211	replication factor C (activator 1) 1	Mus musculus	23-27
9812582-4	1997	Results showed that level of homocysteine was significantly higher in rural pregnant women than that in urban, with 9.31 mumol/L and 5.73 mumol/L, respectively, level of vitamin B12 was lower in rural than that in urban women, with 210.09 pmol/L and 233.35 pmol/L, respectively, and level of folic acid was higher in rural than that in urban women, but no significant difference in deficiency of folic acid between rural and urban was found.	Folic Acid	292-302	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	178-181
9359603-1	1997	10-Formyltetrahydrofolate dehydrogenase (10-FTHFDH) is a folate-binding protein that is important in folate metabolism.	Folic Acid	19-25	aldehyde dehydrogenase 1 family, member L1	Rattus norvegicus	41-50
9359603-2	1997	In addition, 10-FTHFDH catalyzes the rate-limiting step in hepatic folate-dependent formate oxidation.	Folic Acid	67-73	aldehyde dehydrogenase 1 family, member L1	Rattus norvegicus	13-22
9812582-4	1997	Results showed that level of homocysteine was significantly higher in rural pregnant women than that in urban, with 9.31 mumol/L and 5.73 mumol/L, respectively, level of vitamin B12 was lower in rural than that in urban women, with 210.09 pmol/L and 233.35 pmol/L, respectively, and level of folic acid was higher in rural than that in urban women, but no significant difference in deficiency of folic acid between rural and urban was found.	Folic Acid	396-406	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	178-181
9701044-1	1997	A stretch of about 150 amino acids located between the heme and the calmodulin recognition sequence of nitric oxide synthase (NOS) has been strongly conserved within isoforms and was proposed to participate in pteridine binding because of sequence similarities to the folate binding site of dihydrofolate reductase (DHFR).	Folic Acid	268-274	dihydrofolate reductase	Rattus norvegicus	291-314
9159297-1	1997	The treatment efficacy of erythropoietin (EPO) in end-stage renal disease (ESRD) can be limited by deficiencies of iron, folate, or vitamin B12, by hyperparathyroidism, or by aluminum intoxication.	Folic Acid	121-127	erythropoietin	Homo sapiens	26-40
9159297-1	1997	The treatment efficacy of erythropoietin (EPO) in end-stage renal disease (ESRD) can be limited by deficiencies of iron, folate, or vitamin B12, by hyperparathyroidism, or by aluminum intoxication.	Folic Acid	121-127	erythropoietin	Homo sapiens	42-45
9177839-4	1997	In this paper, it is shown that the size of these conjugates can be reduced to the smallest bispecific agent yet described (30 kDa) by attaching folate to a single-chain antibody, scFv, of the anti-TCR antibody KJ16.	Folic Acid	145-151	immunglobulin heavy chain variable region	Homo sapiens	180-184
9177839-6	1997	The optimal folate density was in the range of 5-15 folate molecules per scFv or IgG molecule, which yielded half-maximal lysis values (EC50) of approximately 40 pM (1.2 ng/mL for scFv).	Folic Acid	12-18	immunglobulin heavy chain variable region	Homo sapiens	73-77
9177839-6	1997	The optimal folate density was in the range of 5-15 folate molecules per scFv or IgG molecule, which yielded half-maximal lysis values (EC50) of approximately 40 pM (1.2 ng/mL for scFv).	Folic Acid	12-18	immunglobulin heavy chain variable region	Homo sapiens	180-184
9177839-6	1997	The optimal folate density was in the range of 5-15 folate molecules per scFv or IgG molecule, which yielded half-maximal lysis values (EC50) of approximately 40 pM (1.2 ng/mL for scFv).	Folic Acid	52-58	immunglobulin heavy chain variable region	Homo sapiens	73-77
9177839-6	1997	The optimal folate density was in the range of 5-15 folate molecules per scFv or IgG molecule, which yielded half-maximal lysis values (EC50) of approximately 40 pM (1.2 ng/mL for scFv).	Folic Acid	52-58	immunglobulin heavy chain variable region	Homo sapiens	180-184
9177839-7	1997	Finally, the scFv/folate conjugates could efficiently target tumor cells even in the presence of free folic acid at concentrations that are normally found in serum.	Folic Acid	102-112	immunglobulin heavy chain variable region	Homo sapiens	13-17
9111015-0	1997	RFC-1 gene expression regulates folate absorption in mouse small intestine.	Folic Acid	32-38	replication factor C (activator 1) 1	Mus musculus	0-5
9111015-6	1997	The increase in pH-dependent influx during maturation was associated with an increase in RFC-1 gene expression in the form of a 2.5-kilobase RNA transcript and 58-kDa brush-border membrane protein detected by folate-based affinity labeling and with anti-mouse RFC-1 peptide antibodies.	Folic Acid	209-215	replication factor C (activator 1) 1	Mus musculus	89-94
9111015-9	1997	These results strongly suggest that pH-dependent folate absorption in this tissue is regulated by RFC-1 gene expression.	Folic Acid	49-55	replication factor C (activator 1) 1	Mus musculus	98-103
9123729-19	1997	In the normal prostate where the protein is intracellular, is PSM" antigen keeping folate in nonglutamated forms?	Folic Acid	83-89	folate hydrolase 1	Homo sapiens	62-65
9701044-1	1997	A stretch of about 150 amino acids located between the heme and the calmodulin recognition sequence of nitric oxide synthase (NOS) has been strongly conserved within isoforms and was proposed to participate in pteridine binding because of sequence similarities to the folate binding site of dihydrofolate reductase (DHFR).	Folic Acid	268-274	dihydrofolate reductase	Rattus norvegicus	316-320
9171313-0	1997	Folic acid supplementation improves erythropoietin response.	Folic Acid	0-10	erythropoietin	Homo sapiens	36-50
8988912-6	1997	Folate insufficiency has been implicated in the development of several human and experimental cancers, and aberrations within these regions of the p53 gene that were examined in this study are thought to play an integral role in carcinogenesis.	Folic Acid	0-6	tumor protein p53	Homo sapiens	147-150
7603852-5	1995	Results of a full blood count may suggest the anaemia is caused by a nutritional deficiency of B12 folate or iron.	Folic Acid	99-105	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	95-98
8975761-3	1996	The present study was designed to determine whether components of folate-dependent formate oxidation, e.g., folate and 10-CHO-H4-folate dehydrogenase (10-FDH), exist in retina and whether differences in these components might explain species-determined susceptibility to methanol intoxication.	Folic Acid	66-72	aldehyde dehydrogenase 1 family member L1	Homo sapiens	154-157
9072885-2	1996	During its treatment by recombinant human erythropoietin (rHuEPO) erythropoiesis is accelerated and this increases demands on the supply of dietary erythropoietic precursors (Fe, pyridoxine, folic acid, vitamin B12).	Folic Acid	191-201	erythropoietin	Homo sapiens	42-56
9131013-1	1996	Fragile X syndrome is caused by the expansion and concomitant methylation of a CGG repeat in the 5" untranslated region of the FMR1 gene which results in the transcriptional silencing of the FMR1 gene, delayed replication of the FMR1 locus, and the formation of a folate sensitive fragile site (FRAXA) at Xq27.3.	Folic Acid	264-270	fragile X messenger ribonucleoprotein 1	Homo sapiens	127-131
8664315-7	1996	The expressed folate uptake in the cRNA injected oocyte was (1) 4,4"-diisothiocyanatosilbene-2,2"-disulfonic acid (DIDS)-sensitive; and (2) saturable with an apparent Km of 1.99 +/- 0.32 micrometers and a V(max) of 3782 +/- 188 fmol/oocyte per h. The distribution of mRNA species complementary to IFC1(RFC1) in different mouse tissues was examined by Northern blot analysis.	Folic Acid	14-20	replication factor C (activator 1) 1	Mus musculus	302-306
8793412-1	1996	OBJECTIVE: The present study was undertaken to investigate the relationship between estimated folate and vitamin B12 intakes and their biochemical status in elderly persons.	Folic Acid	94-100	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	113-116
8605127-1	1996	OBJECTIVE: To determine the relation between blood folic acid and serum vitamin B12 in neural tube defect pregnancies using data from the MRC Vitamin Study and a literature review of all studies.	Folic Acid	51-61	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	80-83
8605127-10	1996	A systematic review of all studies from the literature showed that on average, during the 1st trimester of pregnancy, serum folic acid was 0.6 ng/ml lower in neural tube defect pregnancies (P < 0.01), red cell folic acid was 77 ng/ml lower (P < 0.001) and serum vitamin B12 was 38 ng/l lower (P < 0.001).	Folic Acid	124-134	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	276-279
8605127-12	1996	CONCLUSION: our results are consistent with other evidence that folic acid and vitamin B12 levels are lower in women with neural tube defect pregnancies and consistent with evidence from randomised trials which showed that folic acid is protective.	Folic Acid	223-233	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	87-90
8602704-6	1996	Vitamin B12 deficiency was defined as one of the following: 1) a serum vitamin B12 level less than 221 pmol/L and an elevated methylmalonic acid level; 2) a serum vitamin B12 level less than 221 pmol/L and an elevated total homocysteine level that decreased with vitamin B12 treatment; or 3) in patients unavailable for treatment, a serum vitamin B12 level less than 221 pmol/L, a folate level greater than 9 nmol/L, and an elevated total homocysteine level.	Folic Acid	381-387	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	8-11
9816319-6	1996	Preliminary studies have demonstrated binding of pteroylmonoglutamate (folate) to membrane fractions that also cross-reacted with the PSM monoclonal antibody.	Folic Acid	49-69	folate hydrolase 1	Homo sapiens	134-137
9816319-6	1996	Preliminary studies have demonstrated binding of pteroylmonoglutamate (folate) to membrane fractions that also cross-reacted with the PSM monoclonal antibody.	Folic Acid	71-77	folate hydrolase 1	Homo sapiens	134-137
8869665-15	1996	The chronic haemolysis of the patients" blood due to SASP might explain the similar RBC folate values in the two groups because of a relatively higher folate content of young erythrocytes.	Folic Acid	88-94	aspartic peptidase retroviral like 1	Homo sapiens	53-57
8869665-15	1996	The chronic haemolysis of the patients" blood due to SASP might explain the similar RBC folate values in the two groups because of a relatively higher folate content of young erythrocytes.	Folic Acid	151-157	aspartic peptidase retroviral like 1	Homo sapiens	53-57
8869665-16	1996	In conclusion, our results support previous findings of folate deficiency and haemolysis occurring in a considerable fraction of patients receiving treatment with SASP.	Folic Acid	56-62	aspartic peptidase retroviral like 1	Homo sapiens	163-167
8664315-2	1996	In this investigation, we screened a mouse intestinal cDNA library using as probe the cDNA clone of a reduced folate carrier (RFC1) of mouse leukemia L1210 cells, and identified a positive clone, IFC1(RFC1).	Folic Acid	110-116	replication factor C (activator 1) 1	Mus musculus	126-130
9125297-7	1996	We also found that folate depletion significantly enhanced the thrombin- and ADP-induced platelet aggregation (+64 and + 13 percent, respectively).	Folic Acid	19-25	coagulation factor II	Rattus norvegicus	63-71
8646804-7	1996	These sensitivity/resistance profiles were largely similar following cell culture in medium containing 1 nM L-leucovorin, a folate with an affinity for MFR 10-fold lower than that of folic acid, the one exception being the increased sensitivity for ZD1694 seen in the LF-adapted cells with the highest level of MFR expression (MTX(R)-ZR-75-1).	Folic Acid	124-130	signal regulatory protein alpha	Homo sapiens	152-155
8646804-8	1996	These results illustrate that the efficacy of MFR in mediating antifolate transport and cytotoxicity depends on their affinity for the folate antagonist, their degree of expression, and the levels of competing folates.	Folic Acid	67-73	signal regulatory protein alpha	Homo sapiens	46-49
8594875-5	1995	During regeneration following folic acid-induced acute renal failure, IGF-I, IGFBP-3, and IGFBP-5 mRNAs declined in abundance approximately two- to threefold.	Folic Acid	30-40	insulin like growth factor 1	Homo sapiens	70-75
8594875-5	1995	During regeneration following folic acid-induced acute renal failure, IGF-I, IGFBP-3, and IGFBP-5 mRNAs declined in abundance approximately two- to threefold.	Folic Acid	30-40	insulin like growth factor binding protein 5	Homo sapiens	90-97
7548305-13	1995	When using Final mean grades, a positive correlation was shown with folic acid (males) and vitamin B12 (females).	Folic Acid	68-78	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	99-102
7654689-1	1995	Formiminotransferase-cyclodeaminase is a bifunctional enzyme arranged as a circular tetramer of dimers that exhibits the ability to efficiently channel polyglutamylated folate between catalytic sites.	Folic Acid	169-175	formimidoyltransferase cyclodeaminase	Homo sapiens	0-35
7646059-11	1995	NADP(+)-dependent oxidation of 10-HCO-H4PteGlu by 10-FTHFDH was inhibited by the folate anti-metabolite, 5,10-dideazatetrahydrofolate, a known GAR-TF inhibitor.	Folic Acid	81-87	aldehyde dehydrogenase 1 family, member L1	Rattus norvegicus	50-59
7851040-0	1994	Is folate and vitamin B12 supplementation necessary in chronic hemodialysis patients with EPO treatment?	Folic Acid	3-9	erythropoietin	Homo sapiens	90-93
7796091-0	1995	Does folic acid harm people with vitamin B12 deficiency?	Folic Acid	5-15	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	41-44
7713875-14	1995	FR-alpha expressed at sufficient levels can mediate influx of MTX and folates into cells at rates comparable to the reduced folate carrier and hence has pharmacologic and physiologic importance.	Folic Acid	70-77	rabaptin, RAB GTPase binding effector protein 2	Mus musculus	0-8
7713875-14	1995	FR-alpha expressed at sufficient levels can mediate influx of MTX and folates into cells at rates comparable to the reduced folate carrier and hence has pharmacologic and physiologic importance.	Folic Acid	70-76	rabaptin, RAB GTPase binding effector protein 2	Mus musculus	0-8
7873554-6	1995	A hitherto unobserved water molecule is hydrogen bonded to the pteridine N5 and O4 in both molecules of the asymmetric unit of the folate complex (but not the 5dfol or ddTHF complexes), supporting the hypothesis that N5 protonation of bound substrate, an important step of the DHFR reaction, occurs by way of such a water molecule.	Folic Acid	131-137	dihydrofolate reductase	Escherichia coli	277-281
7873554-9	1995	Perhaps this explains why bacterial DHFR is much less effective than vertebrate DHFR in folate reduction.	Folic Acid	88-94	dihydrofolate reductase	Escherichia coli	36-40
7873554-9	1995	Perhaps this explains why bacterial DHFR is much less effective than vertebrate DHFR in folate reduction.	Folic Acid	88-94	dihydrofolate reductase	Escherichia coli	80-84
7745161-5	1995	Supplementary folic acid tended to increase milk folates, milk production, and the percentage of milk protein during the last half of the lactation curve but had no effect on milk folates and milk production during the first 6 wk after parturition when the injections of folic acid increased the percentage of milk protein in multiparous cows but had no effect on primiparous cows.	Folic Acid	14-24	casein beta	Bos taurus	97-109
7622978-7	1995	The adequate serum levels of vitamin B12 and folic acid might be the result of the habit of the workers to consume tonic drinks which contain glucose, caffeine, and vitamins especially vitamins B6, and B12.	Folic Acid	45-55	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	202-205
8587618-0	1995	Folic acid supplementation improves erythropoietin response.	Folic Acid	0-10	erythropoietin	Homo sapiens	36-50
8904026-12	1995	In group S, antrum gastrin was inversely correlated with antrum tryptase (r = -0.903, P < 0.001), and with corpus PGA (r = -0.806, P < 0.05).	Folic Acid	117-120	gastrin	Oryctolagus cuniculus	19-26
7715908-5	1995	On the basis, we have performed a clinical trial to evaluate the impact of low-dose IL-2 plus melatonin on the survival time in metastatic colon cancer, which progressed in response to 5-FU plus folates.	Folic Acid	195-202	interleukin 2	Homo sapiens	84-88
7715908-11	1995	This study suggests that low-dose subcutaneous IL-2 plus melatonin may be effective as a second-line therapy to induce tumor regression and to prolong percent survival at 1 year in metastatic colorectal cancer patients progressing under 5-FU and folates.	Folic Acid	246-253	interleukin 2	Homo sapiens	47-51
7724560-0	1995	Delivery of antisense oligodeoxyribonucleotides against the human epidermal growth factor receptor into cultured KB cells with liposomes conjugated to folate via polyethylene glycol.	Folic Acid	151-157	epidermal growth factor receptor	Homo sapiens	66-98
7724560-1	1995	Antisense oligodeoxyribonucleotides targeted to the epidermal growth factor (EGF) receptor were encapsulated into liposomes linked to folate via a polyethylene glycol spacer (folate-PEG-liposomes) and efficiently delivered into cultured KB cells via folate receptor-mediated endocytosis.	Folic Acid	175-181	epidermal growth factor receptor	Homo sapiens	52-90
7724560-7	1995	Growth inhibition of the oligonucleotide-treated cells was probably due to reduced EGFR expression because indirect immunofluorescence staining of the cells with a monoclonal antibody against the EGFR showed an almost quantitative reduction of the EGFR in cells treated with folate-PEG-liposome-entrapped AEGFR2.	Folic Acid	275-281	epidermal growth factor receptor	Homo sapiens	83-87
7724560-7	1995	Growth inhibition of the oligonucleotide-treated cells was probably due to reduced EGFR expression because indirect immunofluorescence staining of the cells with a monoclonal antibody against the EGFR showed an almost quantitative reduction of the EGFR in cells treated with folate-PEG-liposome-entrapped AEGFR2.	Folic Acid	275-281	epidermal growth factor receptor	Homo sapiens	196-200
7724560-7	1995	Growth inhibition of the oligonucleotide-treated cells was probably due to reduced EGFR expression because indirect immunofluorescence staining of the cells with a monoclonal antibody against the EGFR showed an almost quantitative reduction of the EGFR in cells treated with folate-PEG-liposome-entrapped AEGFR2.	Folic Acid	275-281	epidermal growth factor receptor	Homo sapiens	196-200
8061055-1	1994	The folate receptor (FR), an essential component in the process of folate uptake in various cells, is known to exist in three isoforms, FR-alpha, FR-beta and FR-gamma, with differential tissue expression.	Folic Acid	4-10	folate receptor gamma	Homo sapiens	158-166
8399018-10	1993	Positive correlations were found between the concentrations of folate and vitamin B12 in each fluid.	Folic Acid	63-69	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	82-85
7741859-7	1995	The difference was significant (p = 0.004) in the lower half of the B12 distribution after adjusting for plasma folate.	Folic Acid	112-118	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	68-71
8043612-1	1994	The thermodynamic parameters of the binding of some folate analogues (methotrexate, trimetrexate and trimethoprim) to dihydrofolate reductases from different species have been measured with a flow microcalorimetric method at 37 degrees C. In the absence of NADPH, the three inhibitors exhibited a higher affinity for E. coli DHFR than for vertebrate DHFRs.	Folic Acid	52-58	dihydrofolate reductase	Escherichia coli	325-329
8171746-5	1993	The reduction of cellular folate by methotrexate was also enhanced in combination with IFN-gamma.	Folic Acid	26-32	interferon gamma	Homo sapiens	87-96
8171746-6	1993	Cell cycle delay, resulting in cell growth inhibition of folate depletion, caused the induction of differentiation in U-937 cells, which was found to be greater with methotrexate + IFN-gamma than with methotrexate alone.	Folic Acid	57-63	interferon gamma	Homo sapiens	181-190
8171746-9	1993	The addition of thymidine to the medium also caused reversal of the inhibitory effect of methotrexate and IFN-gamma on cell growth and repletion of the endogenous folate level.	Folic Acid	163-169	interferon gamma	Homo sapiens	106-115
8408019-3	1993	The effect of folylpoly-gamma-glutamate synthetase (FPGS) levels on folate accumulation was investigated in Chinese hamster ovary cells expressing various levels of human and Escherichia coli FPGS activity.	Folic Acid	68-74	folylpolyglutamate synthase, mitochondrial	Cricetulus griseus	14-50
8408019-3	1993	The effect of folylpoly-gamma-glutamate synthetase (FPGS) levels on folate accumulation was investigated in Chinese hamster ovary cells expressing various levels of human and Escherichia coli FPGS activity.	Folic Acid	68-74	folylpolyglutamate synthase, mitochondrial	Cricetulus griseus	52-56
8408020-4	1993	Expression of mitochondrial FPGS activity is required for folate accumulation by mitochondria.	Folic Acid	58-64	folylpolyglutamate synthase, mitochondrial	Cricetulus griseus	28-32
8307991-7	1994	The large increase in FBP2 expression in the F2-MTXrA line correlates with a 10-fold increase in [3H]folic acid membrane surface binding and a 1000-fold decrease in the folic acid growth requirement compared with parental L1210 cells.	Folic Acid	101-111	fructose bisphosphatase 2	Mus musculus	22-26
8307991-7	1994	The large increase in FBP2 expression in the F2-MTXrA line correlates with a 10-fold increase in [3H]folic acid membrane surface binding and a 1000-fold decrease in the folic acid growth requirement compared with parental L1210 cells.	Folic Acid	169-179	fructose bisphosphatase 2	Mus musculus	22-26
8110752-6	1994	Transfection of COS-1 cells with the cDNA for FR-gamma resulted in low expression of a [3H]folic acid binding protein on the cell surface that was GPI-anchored.	Folic Acid	91-101	folate receptor gamma	Homo sapiens	46-54
7925320-2	1994	Vitamin B12 deficiency causes an identical anaemia owing to metabolic trapping of intracellular folate.	Folic Acid	96-102	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	8-11
8159473-1	1993	Human recombinant erythropoietin (rHu-Epo) is now extensively used in chronic renal failures; this treatment, resulting in a correction of the severe anemias seen in hemodialysed patients, may in turn lead to a resistance to rHu-Epo therapy by reason of the shortage of erythropoiesis factors, such as iron, vitamin B12 and folates.	Folic Acid	324-331	erythropoietin	Homo sapiens	18-32
8159473-1	1993	Human recombinant erythropoietin (rHu-Epo) is now extensively used in chronic renal failures; this treatment, resulting in a correction of the severe anemias seen in hemodialysed patients, may in turn lead to a resistance to rHu-Epo therapy by reason of the shortage of erythropoiesis factors, such as iron, vitamin B12 and folates.	Folic Acid	324-331	erythropoietin	Homo sapiens	38-41
8400468-7	1993	Because large doses of folate have been reported to ameliorate B12 deficiency anemia while allowing neurologic damage to progress, and to cause electroencephalogram abnormalities in epileptics, it is important to plan fortification carefully and to monitor both toxicity and benefits.	Folic Acid	23-29	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	63-66
8500219-2	1993	The reduced folate 5,10-methylenetetrahydrofolate (CH2FH4) and its precursor tetrahydrofolate (FH4) are essential cofactors for the formation of a tight ternary complex of thymidylate synthase (TS) and 5-fluoro-2"-deoxyuridine-5"-monophosphate (FdUMP) derived from FUra.	Folic Acid	12-18	thymidylate synthetase	Rattus norvegicus	172-192
8235161-0	1993	[Is it necessary to supplement with folic acid patients in chronic dialysis treated with erythropoietin?].	Folic Acid	36-46	erythropoietin	Homo sapiens	89-103
8235161-1	1993	The need for folate supplementation in patients on chronic hemodialysis receiving erythropoietin (EPO) remains to be determined.	Folic Acid	13-19	erythropoietin	Homo sapiens	82-96
8235161-1	1993	The need for folate supplementation in patients on chronic hemodialysis receiving erythropoietin (EPO) remains to be determined.	Folic Acid	13-19	erythropoietin	Homo sapiens	98-101
8235161-8	1993	We thus recommend the measurement of serum and red cell folate levels during the first and tenth weeks of the induction phase of EPO treatment.	Folic Acid	56-62	erythropoietin	Homo sapiens	129-132
1332963-4	1992	We now report that pancreatic GNMT also contains bound folate in vivo.	Folic Acid	55-61	glycine N-methyltransferase	Homo sapiens	30-34
1426244-2	1992	Such studies of complexes of Escherichia coli DHFR with [4,7,8a,9-13C]- and [2,4a,6-13C]methotrexate (MTX) and [4,6,8a-13C]- and [2,4a,7,9-13C]folic acid confirm that in the binary complexes, MTX binds in two conformational forms and folate binds as a single conformation.	Folic Acid	234-240	dihydrofolate reductase	Escherichia coli	46-50
1426244-3	1992	Earlier studies on the corresponding complexes with Lactobacillus casei DHFR indicated that, in this case, MTX binds as a single conformation whereas folate binds in multiple conformational forms (both in its binary complex and ternary complex with NADP+); two of the bound conformational states for the folate complexes are very different from each other in that there is a 180 degrees difference in their pteridine ring orientation.	Folic Acid	150-156	dihydrofolate reductase	Escherichia coli	72-76
1449544-4	1992	The results indicated a striking difference in the stereospecificity of MFR-1 and MFR-2 for reduced folate coenzymes; MFR-2 preferentially bound to the physiological (6S) diastereoisomers and MFR-1 bound preferentially to the unphysiological (6R) diastereoisomers, while dideazatetrahydrofolate did not show significant stereospecificity for MFR-1.	Folic Acid	100-106	signal regulatory protein alpha	Homo sapiens	72-75
1449544-4	1992	The results indicated a striking difference in the stereospecificity of MFR-1 and MFR-2 for reduced folate coenzymes; MFR-2 preferentially bound to the physiological (6S) diastereoisomers and MFR-1 bound preferentially to the unphysiological (6R) diastereoisomers, while dideazatetrahydrofolate did not show significant stereospecificity for MFR-1.	Folic Acid	100-106	signal regulatory protein alpha	Homo sapiens	82-87
1449544-4	1992	The results indicated a striking difference in the stereospecificity of MFR-1 and MFR-2 for reduced folate coenzymes; MFR-2 preferentially bound to the physiological (6S) diastereoisomers and MFR-1 bound preferentially to the unphysiological (6R) diastereoisomers, while dideazatetrahydrofolate did not show significant stereospecificity for MFR-1.	Folic Acid	100-106	signal regulatory protein alpha	Homo sapiens	118-123
1449544-4	1992	The results indicated a striking difference in the stereospecificity of MFR-1 and MFR-2 for reduced folate coenzymes; MFR-2 preferentially bound to the physiological (6S) diastereoisomers and MFR-1 bound preferentially to the unphysiological (6R) diastereoisomers, while dideazatetrahydrofolate did not show significant stereospecificity for MFR-1.	Folic Acid	100-106	signal regulatory protein alpha	Homo sapiens	82-85
1449544-4	1992	The results indicated a striking difference in the stereospecificity of MFR-1 and MFR-2 for reduced folate coenzymes; MFR-2 preferentially bound to the physiological (6S) diastereoisomers and MFR-1 bound preferentially to the unphysiological (6R) diastereoisomers, while dideazatetrahydrofolate did not show significant stereospecificity for MFR-1.	Folic Acid	100-106	signal regulatory protein alpha	Homo sapiens	82-85
1451343-0	1992	Is folate supplementation necessary in hemodialysis patients on erythropoietin therapy.	Folic Acid	3-9	erythropoietin	Homo sapiens	64-78
1451343-1	1992	The need for folate supplementation in hemodialysis (HD) patients receiving erythropoietin (EPO) therapy remains unknown.	Folic Acid	13-19	erythropoietin	Homo sapiens	76-90
1452946-5	1992	In contrast, IL-2 exposure depressed normal vitamins A, B6, carotene, and folate levels to subnormal; 90% of the patients became B6 hypovitaminemic; 60% for vitamin A, 80% for carotene, and 45% for folate.	Folic Acid	74-80	interleukin 2	Homo sapiens	13-17
1452946-5	1992	In contrast, IL-2 exposure depressed normal vitamins A, B6, carotene, and folate levels to subnormal; 90% of the patients became B6 hypovitaminemic; 60% for vitamin A, 80% for carotene, and 45% for folate.	Folic Acid	198-204	interleukin 2	Homo sapiens	13-17
1325493-1	1992	The influence of folic acid and several antagonists of the folic acid metabolism on neutrophil superoxide generation was investigated with the cytochrome c reduction assay.	Folic Acid	59-69	cytochrome c, somatic	Homo sapiens	143-155
1554877-6	1992	The renal clearance of N4 during the first day, for four out of the six volunteers, was twice as high as on the following days (8 vs 4 ml min-1).	Folic Acid	23-25	CD59 molecule (CD59 blood group)	Homo sapiens	138-143
1419906-3	1992	The results show that both TGF-beta 1 and razoxane induce maximal c-jun mRNA expression 4 days after initiation of treatment concurrent with the development of PGA.	Folic Acid	160-163	transforming growth factor beta 1	Homo sapiens	27-37
1516378-5	1992	In eight patients prolonged oral administration of folic acid with simultaneous parenteral treatment with vitamin B12 and oral ascorbic acid was followed by definite repigmentation without side effects.	Folic Acid	51-61	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	114-117
1517041-2	1992	Specifically we sought to determine whether the folate substrates of methionine synthase and the products of folylpolyglutamate synthetase are altered during iron deficiency in vivo.	Folic Acid	48-54	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	69-88
2069475-1	1991	The occurrence of increased levels of blood phenylalanine after therapeutic administration of folate analogues has been occasionally reported and attributed to the inhibition of dihydropteridine reductase, an enzyme maintaining the cofactor of phenylalanine hydroxylase in its active tetrahydrogenated form (tetrahydrobiopterin).	Folic Acid	94-100	quinoid dihydropteridine reductase	Homo sapiens	178-204
1657875-1	1991	The enzymes 7,8-dihydroxymethylpterin-pyrophosphokinase (HPPK) and 7,8-dihydropteroate synthase (DHPS), which act sequentially in the folate pathway, were purified to homogeneity from crude extracts of Escherichia coli MC4100.	Folic Acid	134-140	dihydropteroate synthetase	Escherichia coli	67-95
1657875-1	1991	The enzymes 7,8-dihydroxymethylpterin-pyrophosphokinase (HPPK) and 7,8-dihydropteroate synthase (DHPS), which act sequentially in the folate pathway, were purified to homogeneity from crude extracts of Escherichia coli MC4100.	Folic Acid	134-140	dihydropteroate synthetase	Escherichia coli	97-101
1915851-5	1991	In contrast, only one conformation was observed for both the DHFR/folate and DHFR/folate/NADP+ complexes.	Folic Acid	66-72	dihydrofolate reductase	Escherichia coli	61-65
1915851-5	1991	In contrast, only one conformation was observed for both the DHFR/folate and DHFR/folate/NADP+ complexes.	Folic Acid	82-88	dihydrofolate reductase	Escherichia coli	77-81
1915851-6	1991	However, the 15N chemical shift of [5-15N]folate in the binary DHFR/folate complex is 7.28 ppm upfield from that of the ternary complex, suggesting the possible loss of a hydrogen bonding to N5 of folate in the ternary complex.	Folic Acid	42-48	dihydrofolate reductase	Escherichia coli	63-67
1915851-6	1991	However, the 15N chemical shift of [5-15N]folate in the binary DHFR/folate complex is 7.28 ppm upfield from that of the ternary complex, suggesting the possible loss of a hydrogen bonding to N5 of folate in the ternary complex.	Folic Acid	68-74	dihydrofolate reductase	Escherichia coli	63-67
33806898-7	2021	The result showed that ZINC8577218, ZINC95618747, and ZINC4261765 might be the potentially potent inhibitors for DHODH.	Folic Acid	23-34	dihydroorotate dehydrogenase (quinone)	Homo sapiens	113-118
1957614-6	1991	High folate concentrations also seemed to be a consequence of Vitamin B12 deficiency.	Folic Acid	5-11	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	70-73
2313380-0	1990	Relative folate bioavailability from diets containing human, bovine and goat milk.	Folic Acid	9-15	Weaning weight-maternal milk	Bos taurus	77-81
2313380-8	1990	Using plasma folate as the response criterion, dietary incorporation of human milk significantly enhanced folate bioavailability by 75% (P less than 0.01).	Folic Acid	13-19	Weaning weight-maternal milk	Bos taurus	78-82
2313380-8	1990	Using plasma folate as the response criterion, dietary incorporation of human milk significantly enhanced folate bioavailability by 75% (P less than 0.01).	Folic Acid	106-112	Weaning weight-maternal milk	Bos taurus	78-82
2313380-9	1990	With kidney as the response tissue, folate bioavailability from diets containing human and bovine milk was significantly enhanced over milk-free diets.	Folic Acid	36-42	Weaning weight-maternal milk	Bos taurus	98-102
2313380-9	1990	With kidney as the response tissue, folate bioavailability from diets containing human and bovine milk was significantly enhanced over milk-free diets.	Folic Acid	36-42	Weaning weight-maternal milk	Bos taurus	135-139
2313380-10	1990	These results show that incorporation of human or bovine milk into diets enhances folate bioavailability and that plasma and kidney folate concentrations are sensitive and specific indicators of folate bioavailability.	Folic Acid	82-88	Weaning weight-maternal milk	Bos taurus	57-61
33775768-0	2021	Mechanistic insight into glycation inhibition of human serum albumin by vitamin B9: Multispectroscopic and molecular docking approach.	Folic Acid	72-82	albumin	Homo sapiens	55-68
2041378-6	1991	The normal range of serum vitamin B12 and folic acid was established in 58 healthy controls and was found to be 190-1020 pg/ml for serum vitamin B12 and 2.4-16.1 ng/ml for folic acid.	Folic Acid	42-52	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	145-148
2041378-6	1991	The normal range of serum vitamin B12 and folic acid was established in 58 healthy controls and was found to be 190-1020 pg/ml for serum vitamin B12 and 2.4-16.1 ng/ml for folic acid.	Folic Acid	172-182	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	34-37
1758881-5	1991	The possibility of this long-range polarization of NADPH was originally proposed based on a previous study of ligand binding to DHFR where a conserved structural motif of three positively charged residues was found to play a major role in polarizing the substrate folate over its entire length of 18 A.	Folic Acid	264-270	dihydrofolate reductase	Escherichia coli	128-132
2210962-0	1990	Interrelationship between serum concentrations of methionine, vitamin B12 and folate.	Folic Acid	78-84	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	70-73
23468202-11	2013	As folic acid plays an important role in the development of the neural tube, vitamin B12 deficit might have some impact on the development of Chiari malformations.	Folic Acid	3-13	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	85-88
34863637-0	2022	Folic acid functionalized molybdenum oxide quantum dots for the detection of Cu2+ ion and alkaline phosphatase via fluorescence turn off-on mechanism.	Folic Acid	0-10	alkaline phosphatase, placental	Homo sapiens	90-110
34863637-2	2022	Herein, folic acid functionalized molybdenum oxide quantum dots (FA-MoOx QDs) are explored as fluorescence "turn- off and on" probes for assaying of Cu2+ ion and ALP, respectively.	Folic Acid	8-18	alkaline phosphatase, placental	Homo sapiens	162-165
34934172-0	2021	Folate deficiency disturbs PEG10 methylation modifications in human spina bifida.	Folic Acid	0-6	paternally expressed 10	Homo sapiens	27-32
34967850-11	2022	Highest vs. lowest quartiles of aggregated genetic risk scores from SNVs in MTHFR and MTRR were associated with 14.8% to 18.9% lower RBC folate concentrations.	Folic Acid	137-143	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	86-90
34953021-5	2022	Meanwhile, the results of animal model and spermatocyte line (GC-2) also found that folic acid deficiency can increase the methylation level in Rad54 promoter region, increased sperm DFI in mice, increased the expression of gamma-H2AX, that is, DNA injury marker protein, and increased sensitivity of GC-2 to external damage and stimulation.	Folic Acid	84-94	guanylate cyclase 2f	Mus musculus	62-66
34953021-5	2022	Meanwhile, the results of animal model and spermatocyte line (GC-2) also found that folic acid deficiency can increase the methylation level in Rad54 promoter region, increased sperm DFI in mice, increased the expression of gamma-H2AX, that is, DNA injury marker protein, and increased sensitivity of GC-2 to external damage and stimulation.	Folic Acid	84-94	H2A.X variant histone	Mus musculus	224-234
34953021-5	2022	Meanwhile, the results of animal model and spermatocyte line (GC-2) also found that folic acid deficiency can increase the methylation level in Rad54 promoter region, increased sperm DFI in mice, increased the expression of gamma-H2AX, that is, DNA injury marker protein, and increased sensitivity of GC-2 to external damage and stimulation.	Folic Acid	84-94	guanylate cyclase 2f	Mus musculus	301-305
34953855-8	2022	We identified human dihydrofolate reductase (DHFR) as a target of pyrimethamine and demonstrated that the STAT3-inhibitory effects of pyrimethamine are the result of a deficiency in reduced folate downstream of DHFR inhibition, implicating folate metabolism in the regulation of STAT3 transcriptional activity.	Folic Acid	190-196	signal transducer and activator of transcription 3	Homo sapiens	106-111
34953855-8	2022	We identified human dihydrofolate reductase (DHFR) as a target of pyrimethamine and demonstrated that the STAT3-inhibitory effects of pyrimethamine are the result of a deficiency in reduced folate downstream of DHFR inhibition, implicating folate metabolism in the regulation of STAT3 transcriptional activity.	Folic Acid	190-196	signal transducer and activator of transcription 3	Homo sapiens	279-284
34953855-8	2022	We identified human dihydrofolate reductase (DHFR) as a target of pyrimethamine and demonstrated that the STAT3-inhibitory effects of pyrimethamine are the result of a deficiency in reduced folate downstream of DHFR inhibition, implicating folate metabolism in the regulation of STAT3 transcriptional activity.	Folic Acid	240-246	signal transducer and activator of transcription 3	Homo sapiens	106-111
34953855-8	2022	We identified human dihydrofolate reductase (DHFR) as a target of pyrimethamine and demonstrated that the STAT3-inhibitory effects of pyrimethamine are the result of a deficiency in reduced folate downstream of DHFR inhibition, implicating folate metabolism in the regulation of STAT3 transcriptional activity.	Folic Acid	240-246	signal transducer and activator of transcription 3	Homo sapiens	279-284
34895361-1	2021	The objective was to examine the prospective relationship between folate and vitamin B12 (B12) status and incident depressive symptoms in a representative cohort of community-dwelling older people.	Folic Acid	66-72	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	90-93
34895361-2	2021	This was a longitudinal study utilising the Irish Longitudinal Study on Aging (n =3,849 aged >=50 years) and investigated the relationship between blood plasma folate and B12 levels at baseline (wave 1) and incident depressive symptoms at 2 and 4 years (waves 2 and 3).	Folic Acid	160-166	WASP family member 1	Homo sapiens	195-201
34895361-9	2021	Both B12 and folate plasma concentrations were lower in the group with incident depressive symptoms vs. non depressed (folate: 21.4 vs. 25.1 nmol/L; P=0.0003); (B12: 315.7 vs. 335.9 pmol/L; P=0.0148).	Folic Acid	119-125	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	5-8
34954983-9	2021	Our results demonstrated that the risk of persistent infection (aRR=2.50, 95%CI: 1.55-4.02) and from negative to positive (aRR=4.55, 95%CI: 2.52-8.23) in the low level of folate were significantly higher than that in the high level of folate, especially the risk of homotype persistent infection (aRR=2.72, 95%CI: 1.51-4.90).	Folic Acid	171-177	arrestin beta 2	Homo sapiens	64-69
34954983-9	2021	Our results demonstrated that the risk of persistent infection (aRR=2.50, 95%CI: 1.55-4.02) and from negative to positive (aRR=4.55, 95%CI: 2.52-8.23) in the low level of folate were significantly higher than that in the high level of folate, especially the risk of homotype persistent infection (aRR=2.72, 95%CI: 1.51-4.90).	Folic Acid	171-177	arrestin beta 2	Homo sapiens	297-302
34954983-9	2021	Our results demonstrated that the risk of persistent infection (aRR=2.50, 95%CI: 1.55-4.02) and from negative to positive (aRR=4.55, 95%CI: 2.52-8.23) in the low level of folate were significantly higher than that in the high level of folate, especially the risk of homotype persistent infection (aRR=2.72, 95%CI: 1.51-4.90).	Folic Acid	235-241	arrestin beta 2	Homo sapiens	64-69
34954983-9	2021	Our results demonstrated that the risk of persistent infection (aRR=2.50, 95%CI: 1.55-4.02) and from negative to positive (aRR=4.55, 95%CI: 2.52-8.23) in the low level of folate were significantly higher than that in the high level of folate, especially the risk of homotype persistent infection (aRR=2.72, 95%CI: 1.51-4.90).	Folic Acid	235-241	arrestin beta 2	Homo sapiens	297-302
34755744-4	2021	By loading DiR into the hydrophobic domain of folic acid-icodextrin-polycaprolactone (FA-ICO-PCL, FIP) and cisplatin-icodextrin-polycaprolactone (Pt-ICO-PCL, PtIP) co-assembly, the resultant DiR@(PtIP + FIP) (DPtFIP) NPs had a diameter of around 70 nm and showed excellent tumor targeting ability and negligible side effects.	Folic Acid	46-56	arginine vasopressin receptor 2	Homo sapiens	11-14
34917229-0	2021	Folic Acid Protects Melanocytes from Oxidative Stress via Activation of Nrf2 and Inhibition of HMGB1.	Folic Acid	0-10	NFE2 like bZIP transcription factor 2	Homo sapiens	72-76
34755744-4	2021	By loading DiR into the hydrophobic domain of folic acid-icodextrin-polycaprolactone (FA-ICO-PCL, FIP) and cisplatin-icodextrin-polycaprolactone (Pt-ICO-PCL, PtIP) co-assembly, the resultant DiR@(PtIP + FIP) (DPtFIP) NPs had a diameter of around 70 nm and showed excellent tumor targeting ability and negligible side effects.	Folic Acid	46-56	arginine vasopressin receptor 2	Homo sapiens	191-194
34601068-1	2021	In this study, biodegradable and thermosensitive F127 hydrogel containing folic acid.MgO:ZnO/chitosan hybrid particles (FMZC) were fabricated as a 3D mesenchymal stem cells (MSCs) delivery vehicle for regenerative medicine and wound healing purposes, in such a way to be responsive to lysozyme and UVA irradiation.	Folic Acid	74-84	lysozyme	Homo sapiens	285-293
34857394-4	2021	All randomized controlled trials that examined the influence of folic acid supplementation on C-reactive protein, interleukin 6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) were included.	Folic Acid	64-74	C-reactive protein	Homo sapiens	94-112
34857394-7	2021	Folic acid supplementation significantly reduced serum levels of C-reactive protein (mean difference (MD), -0.21 mg/L; 95% CI, -0.41 to -0.01; n = 16), TNF-alpha (MD, -14.88 pg/mL; 95% CI, -23.68 to -6.09; n = 10), and IL-6 (MD, -0.93 pg/mL; 95% CI, -1.72 to -0.14; n = 11).	Folic Acid	0-10	C-reactive protein	Homo sapiens	65-83
34857394-7	2021	Folic acid supplementation significantly reduced serum levels of C-reactive protein (mean difference (MD), -0.21 mg/L; 95% CI, -0.41 to -0.01; n = 16), TNF-alpha (MD, -14.88 pg/mL; 95% CI, -23.68 to -6.09; n = 10), and IL-6 (MD, -0.93 pg/mL; 95% CI, -1.72 to -0.14; n = 11).	Folic Acid	0-10	tumor necrosis factor	Homo sapiens	152-161
34857394-7	2021	Folic acid supplementation significantly reduced serum levels of C-reactive protein (mean difference (MD), -0.21 mg/L; 95% CI, -0.41 to -0.01; n = 16), TNF-alpha (MD, -14.88 pg/mL; 95% CI, -23.68 to -6.09; n = 10), and IL-6 (MD, -0.93 pg/mL; 95% CI, -1.72 to -0.14; n = 11).	Folic Acid	0-10	interleukin 6	Homo sapiens	219-223
34857394-9	2021	A significant nonlinear association was also found between folic acid dosage (Pnonlinearity <0.001) and duration of administration (Pnonlinearity <0.001) with serum TNF-alpha levels.	Folic Acid	59-69	tumor necrosis factor	Homo sapiens	165-174
34710844-7	2021	METHODS: In this research, we utilized superparamagnetic iron oxide-based NPs (SPIONs) combined with chitosan lactate (CL) and folic acid (FA) nanoparticles (NPs) loaded with TIGIT-siRNA and HIF-1alpha- siRNA for suppressing TIGIT and HIF-1alpha in tumor cells and evaluated the consequences of this treatment strategy on tumor growth, apoptosis, and metastasis.	Folic Acid	127-137	hypoxia inducible factor 1 subunit alpha	Homo sapiens	235-245
34533844-3	2021	Methylenetetrahydrofolate dehydrogenase 1 like (MTHFD1L), a metabolic enzyme of the folate cycle regulating the production of formate, was identified as a downstream target of melatonin.	Folic Acid	84-90	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	0-41
34175159-4	2021	RESULTS: We found that the 85 CEA-positive or 25 SCC-Ag-positive OL patients had a significantly lower mean serum folic acid level and a significantly higher mean serum homocysteine level as well as significantly higher frequencies of serum folic acid deficiency and hyperhomocysteinemia than 184 healthy control subjects.	Folic Acid	114-124	CEA cell adhesion molecule 3	Homo sapiens	30-33
34175159-4	2021	RESULTS: We found that the 85 CEA-positive or 25 SCC-Ag-positive OL patients had a significantly lower mean serum folic acid level and a significantly higher mean serum homocysteine level as well as significantly higher frequencies of serum folic acid deficiency and hyperhomocysteinemia than 184 healthy control subjects.	Folic Acid	241-251	CEA cell adhesion molecule 3	Homo sapiens	30-33
34358572-7	2021	TNF-alpha-treated mice presented increased p38MAPK phosphorylation and decreased Akt phosphorylation, and the later effect was prevented by folic acid (10 mg/kg, p.o.).	Folic Acid	140-150	tumor necrosis factor	Mus musculus	0-9
34917626-16	2021	Moreover, our results provide preliminary evidence for MTRR genetic polymorphisms, involving folate metabolism function, may be related to the susceptibility to agitation.	Folic Acid	93-99	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	55-59
34490995-2	2021	Mutation of the PAX3 transcription factor prevents neural tube closure, leading to cranial and spinal NTDs whose frequency is responsive to folate status.	Folic Acid	140-146	paired box 3	Mus musculus	16-20
34546337-7	2021	Our results suggest that CYP2U1 deficiency disrupts mitochondrial function and impacts proper neurodevelopment, which could be prevented by folate supplementation in our mouse model, followed by a neurodegenerative process altering multiple neuronal and extraneuronal tissues.	Folic Acid	140-146	cytochrome P450, family 2, subfamily u, polypeptide 1	Mus musculus	25-31
34579532-0	2021	All-Trans Retinoic Acid and Doxorubicin Delivery by Folic Acid Modified Polymeric Micelles for the Modulation of Pin1-Mediated DOX-Induced Breast Cancer Stemness and Metastasis.	Folic Acid	52-62	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	113-117
34666761-9	2021	Further, based on the fact that folate receptor (FR) is over-expressed in most solid tumors and it has been identified to be a cancer stem cell surface marker in colon cancer, we took folate as the targeting ligand and used carboxymethyl-beta-cyclodextrin (CM-beta-CD) to carry BBA and thus prepared a novel inclusion complex of BBA/FA-PEG-CM-beta-CD.	Folic Acid	184-190	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	343-350
34881229-0	2021	Folic Acid-Modified miR-491-5p-Loaded ZIF-8 Nanoparticles Inhibit Castration-Resistant Prostate Cancer by Regulating the Expression of EPHX1.	Folic Acid	0-10	microRNA 491	Mus musculus	20-27
34881229-0	2021	Folic Acid-Modified miR-491-5p-Loaded ZIF-8 Nanoparticles Inhibit Castration-Resistant Prostate Cancer by Regulating the Expression of EPHX1.	Folic Acid	0-10	epoxide hydrolase 1, microsomal	Mus musculus	135-140
34881229-8	2021	After loading miR-491-5p into ZIF-8, we modified the ZIF-8 surface with folic acid (FA) as the target group (FA@ZIF-8).	Folic Acid	72-82	microRNA 491	Mus musculus	14-21
34831280-7	2021	Furthermore, STAT6 knockout mice exhibited significantly less CD206 and PDGFR-beta dual-positive fibroblast accumulation and M2 macrophage polarization in the kidney with folic acid nephropathy.	Folic Acid	171-181	platelet derived growth factor receptor, alpha polypeptide	Mus musculus	72-82
34668502-0	2021	Study of the interaction of folic acid-modified gold nanorods and fibrinogen through microfluidics: implications for protein adsorption, incorporation and viability of cancer cells.	Folic Acid	28-38	fibrinogen beta chain	Homo sapiens	66-76
34727921-11	2021	Finally six hub genes of PGA were identified, including ADCY2, CXCL1, FPRL1, GPR109B, GPR109A and ADCY3, which were validated in a separate dataset of GSE137268.	Folic Acid	25-28	adenylate cyclase 2	Homo sapiens	56-61
34727921-11	2021	Finally six hub genes of PGA were identified, including ADCY2, CXCL1, FPRL1, GPR109B, GPR109A and ADCY3, which were validated in a separate dataset of GSE137268.	Folic Acid	25-28	hydroxycarboxylic acid receptor 2	Homo sapiens	86-93
34556823-3	2021	The present study reports that the expression of MHCII molecules in renal cortical tubules is upregulated in mouse renal fibrosis models generated by unilateral ureter obstruction (UUO) and folic acid (FA).	Folic Acid	190-200	histocompatibility-2, MHC	Mus musculus	49-54
34692767-14	2021	Folic acid reduced NLRP3 inflammasome-mediated pyroptosis by down-regulating the Hippo signaling pathway, thereby effectively reducing T2DM-induced damage in H9C2 cells and animals.	Folic Acid	0-10	NLR family, pyrin domain containing 3	Rattus norvegicus	19-24
34296321-10	2021	Higher B12 was associated with 14.4% lower RR of IADPSG-GDM (0.856; 95% CI 0.786, 0.933; p = 0.0004) after adjusting for key confounders (age, parity, smoking status, ethnicity, family history, household income and folate status).	Folic Acid	215-221	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	7-10
34289180-1	2021	The aim of this study was to evaluate, in a case-control design, the association between maternal genotypes for variants in 23 genes involved in folate/one-carbon metabolism and nonsyndromic cleft lip with or without cleft palate (NSCL/P) in a Chilean population.	Folic Acid	145-151	nescient helix-loop-helix 1	Homo sapiens	231-235
34331825-8	2021	Furthermore, an inverse association was observed between high dietary intake of vitamin B6 (OR vitaminB6 : 0.28; 95% CI: 0.08, 1.00; P=0.05) and vitamin B9 (OR vitaminB9 : 0.20; 95% CI: 0.06, 0.70; P=0.01) with hs-CRP level.	Folic Acid	145-155	C-reactive protein	Homo sapiens	214-217
34474604-7	2021	Meanwhile, folic acid deficiency decreased Cav-1 expression in the testis tissue and increased endoplasmic reticulum stress-related PERK, eIF2alpha, ATF4, CHOP gene expression.	Folic Acid	11-21	activating transcription factor 4	Mus musculus	149-153
34474604-8	2021	Our results suggest that folic acid deficiency can affect male reproduction through the Cav-1-PERK-eIFalpha-ATF4-CHOP pathway.Abbreviations: ATF4: activating transcription factor 4; Ca2+: calcium ion; Cav-1: Caveolin-1; CCK-8: cell counting kit-8; CHOP: CCAAT-enhancer-binding protein homologous protein; DNA: Deoxyribonucleic acid; DSB: double strand breakage; eIF2alpha: eukaryotic Initiation Factor 2 alpha; ER: endoplasmic reticulum; FD: folic acid deficiency; FITC: fluorescein isothiocyanate; HE: hematoxylin and eosin; H3K4me3: histone H3 lysine 4 trimethylation; PERK: protein kinase RNA-like endoplasmic reticulum kinase; PI: propidium iodide; RT-qPCR: quantitative reverse transcription PCR; TUNEL: TdT mediated dUTP Nick End Labeling.	Folic Acid	25-35	activating transcription factor 4	Mus musculus	108-112
34474604-8	2021	Our results suggest that folic acid deficiency can affect male reproduction through the Cav-1-PERK-eIFalpha-ATF4-CHOP pathway.Abbreviations: ATF4: activating transcription factor 4; Ca2+: calcium ion; Cav-1: Caveolin-1; CCK-8: cell counting kit-8; CHOP: CCAAT-enhancer-binding protein homologous protein; DNA: Deoxyribonucleic acid; DSB: double strand breakage; eIF2alpha: eukaryotic Initiation Factor 2 alpha; ER: endoplasmic reticulum; FD: folic acid deficiency; FITC: fluorescein isothiocyanate; HE: hematoxylin and eosin; H3K4me3: histone H3 lysine 4 trimethylation; PERK: protein kinase RNA-like endoplasmic reticulum kinase; PI: propidium iodide; RT-qPCR: quantitative reverse transcription PCR; TUNEL: TdT mediated dUTP Nick End Labeling.	Folic Acid	25-35	activating transcription factor 4	Mus musculus	141-145
34474604-8	2021	Our results suggest that folic acid deficiency can affect male reproduction through the Cav-1-PERK-eIFalpha-ATF4-CHOP pathway.Abbreviations: ATF4: activating transcription factor 4; Ca2+: calcium ion; Cav-1: Caveolin-1; CCK-8: cell counting kit-8; CHOP: CCAAT-enhancer-binding protein homologous protein; DNA: Deoxyribonucleic acid; DSB: double strand breakage; eIF2alpha: eukaryotic Initiation Factor 2 alpha; ER: endoplasmic reticulum; FD: folic acid deficiency; FITC: fluorescein isothiocyanate; HE: hematoxylin and eosin; H3K4me3: histone H3 lysine 4 trimethylation; PERK: protein kinase RNA-like endoplasmic reticulum kinase; PI: propidium iodide; RT-qPCR: quantitative reverse transcription PCR; TUNEL: TdT mediated dUTP Nick End Labeling.	Folic Acid	25-35	activating transcription factor 4	Mus musculus	147-180
34358572-0	2021	Behavioral and neurochemical effects of folic acid in a mouse model of depression induced by TNF-alpha.	Folic Acid	40-50	tumor necrosis factor	Mus musculus	93-102
34358572-3	2021	Folic acid reduced the immobility time in the tail suspension test (TST) in control mice (10-50 mg/kg, p.o) and abolished the depressive-like behavior elicited by TNF-alpha (0.001 fg/site, i.c.v.)	Folic Acid	0-10	tumor necrosis factor	Mus musculus	163-172
34358572-7	2021	TNF-alpha-treated mice presented increased p38MAPK phosphorylation and decreased Akt phosphorylation, and the later effect was prevented by folic acid (10 mg/kg, p.o.).	Folic Acid	140-150	thymoma viral proto-oncogene 1	Mus musculus	81-84
34358572-9	2021	The results indicate the efficacy of folic acid to counteract the depressive-like behavior induced by a pro-inflammatory cytokine, an effect that might be associated with the activation of monoaminergic systems, inhibition of N-methyl-D-aspartate (NMDA) receptors and nitric oxide (NO) synthesis, as well as Akt modulation.	Folic Acid	37-47	thymoma viral proto-oncogene 1	Mus musculus	308-311
34373711-0	2021	Lidocaine liposome modified with folic acid suppresses the proliferation and motility of glioma cells via targeting the PI3K/AKT pathway.	Folic Acid	33-43	thymoma viral proto-oncogene 1	Mus musculus	125-128
34603014-0	2021	Folate Reverses NF-kappaB p65/Rela/IL-6 Level Induced by Hyperhomocysteinemia in Spontaneously Hypertensive Rats.	Folic Acid	0-6	synaptotagmin 1	Rattus norvegicus	26-29
34603014-0	2021	Folate Reverses NF-kappaB p65/Rela/IL-6 Level Induced by Hyperhomocysteinemia in Spontaneously Hypertensive Rats.	Folic Acid	0-6	interleukin 6	Rattus norvegicus	35-39
34603014-10	2021	Furthermore, folate inhibited the expression of IL-6 and NF-kappaB p65/Rela, reduced the levels of MDA and HHcy, but significantly increased the SOD level.	Folic Acid	13-19	interleukin 6	Rattus norvegicus	48-52
34603014-10	2021	Furthermore, folate inhibited the expression of IL-6 and NF-kappaB p65/Rela, reduced the levels of MDA and HHcy, but significantly increased the SOD level.	Folic Acid	13-19	synaptotagmin 1	Rattus norvegicus	67-70
34603014-12	2021	However, folate demonstrated anti-inflammatory properties and reversed the NF-kappaB p65/Rela/IL-6 level induced by HHcy in hypertensive rats.	Folic Acid	9-15	synaptotagmin 1	Rattus norvegicus	85-88
34603014-12	2021	However, folate demonstrated anti-inflammatory properties and reversed the NF-kappaB p65/Rela/IL-6 level induced by HHcy in hypertensive rats.	Folic Acid	9-15	interleukin 6	Rattus norvegicus	94-98
34160104-6	2021	We found increased numbers of S100A4 positive cells expressing PKM2 in renal tissues from mice with AKI induced via folic acid or ischemia/reperfusion (I/R).	Folic Acid	116-126	S100 calcium binding protein A4	Mus musculus	30-36
34440885-1	2021	Since activated macrophages express a functional folate receptor beta (FRbeta), targeting this macrophage population with folate-linked drugs could increase selectivity to treat inflammatory diseases.	Folic Acid	122-128	rabaptin, RAB GTPase binding effector protein 2	Rattus norvegicus	71-77
34440885-4	2021	Kidney protection with EC2319 was blocked by a folate competitor, indicating that its mechanism of action was specifically FRbeta-mediated.	Folic Acid	47-53	rabaptin, RAB GTPase binding effector protein 2	Rattus norvegicus	123-129
34397023-0	2021	Individualized Supplement of Folic Acid Based on the Gene Polymorphisms of MTHER/MTRR Reduced the Incidence of Adverse Pregnancy Outcomes and Newborn Defects.	Folic Acid	29-39	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	81-85
34397023-9	2021	Results: Based on the genotype of MTHFR and MTRR, women were identified as five risk levels of folic acid metabolism.	Folic Acid	95-105	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	44-48
34244426-2	2021	Here, we show that the mitochondrial methylenetetrahydrofolate dehydrogenase (MTHFD2) is transcriptionally suppressed by p53, and its up-regulation by p53 inactivation leads to increased folate metabolism, de novo purine synthesis, and tumor growth in vivo and in vitro.	Folic Acid	187-193	tumor protein p53	Homo sapiens	151-154
34371837-3	2021	To bridge this knowledge gap, this systematic review and meta-analysis of randomized controlled trials (RCTs) aimed to evaluate the effects of folic acid supplementation on serum concentrations of the inflammatory markers C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha).	Folic Acid	143-153	C-reactive protein	Homo sapiens	222-240
34371837-3	2021	To bridge this knowledge gap, this systematic review and meta-analysis of randomized controlled trials (RCTs) aimed to evaluate the effects of folic acid supplementation on serum concentrations of the inflammatory markers C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha).	Folic Acid	143-153	C-reactive protein	Homo sapiens	242-245
34371837-3	2021	To bridge this knowledge gap, this systematic review and meta-analysis of randomized controlled trials (RCTs) aimed to evaluate the effects of folic acid supplementation on serum concentrations of the inflammatory markers C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha).	Folic Acid	143-153	interleukin 6	Homo sapiens	248-261
34371837-3	2021	To bridge this knowledge gap, this systematic review and meta-analysis of randomized controlled trials (RCTs) aimed to evaluate the effects of folic acid supplementation on serum concentrations of the inflammatory markers C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha).	Folic Acid	143-153	interleukin 6	Homo sapiens	263-267
34371837-3	2021	To bridge this knowledge gap, this systematic review and meta-analysis of randomized controlled trials (RCTs) aimed to evaluate the effects of folic acid supplementation on serum concentrations of the inflammatory markers C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha).	Folic Acid	143-153	tumor necrosis factor	Homo sapiens	274-301
34371837-3	2021	To bridge this knowledge gap, this systematic review and meta-analysis of randomized controlled trials (RCTs) aimed to evaluate the effects of folic acid supplementation on serum concentrations of the inflammatory markers C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha).	Folic Acid	143-153	tumor necrosis factor	Homo sapiens	303-312
34371837-8	2021	The dose-response analysis demonstrated a significant relationship between an elevated dosage of folic acid supplementation and lower CRP concentrations (p = 0.002).	Folic Acid	97-107	C-reactive protein	Homo sapiens	134-137
34371837-9	2021	Conclusions: We found that folic acid supplementation may improve inflammation by attenuating serum concentrations of CRP but without significant effects on IL-6 and TNF-alpha.	Folic Acid	27-37	C-reactive protein	Homo sapiens	118-121
34611067-0	2021	The Relationship between Folic Acid and Vitamin B12 Serum Levels with High Sensitivity C-reactive Protein and Homocysteine in Chronic Hemodialysis Patients: A Cross-sectional Study.	Folic Acid	25-35	C-reactive protein	Homo sapiens	87-105
34251183-4	2021	Two approaches were established based on an orthogonal fluorenylmethyloxycarbonyl (Fmoc)-protection strategy to enable a modular buildup of an albumin-binding DOTA conjugate (known as OxFol-1) using folic acid (oxidized folate version) as a targeting agent.	Folic Acid	199-209	albumin	Homo sapiens	143-150
34251183-9	2021	Radiolabeling with lutetium-177 was feasible at high molar activity, and the resulting radioconjugates were stable over at least 24 h. Biodistribution and SPECT/CT imaging studies confirmed the favorable effect of an albumin-binding entity to increase the tumor uptake and reduce kidney retention of folate radioconjugates.	Folic Acid	300-306	albumin	Homo sapiens	217-224
34445544-2	2021	We previously found that folate deprivation induces drug resistance in hepatocellular carcinoma; here, we assessed whether disrupted cytoplasmic folate metabolism could mimic FD-induced metastasis and affect the sensitivity of NSCLC cells to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs).	Folic Acid	145-151	epidermal growth factor receptor	Homo sapiens	303-307
34452213-0	2021	Folate-Equipped Cationic Liposomes Deliver Anti-MDR1-siRNA to the Tumor and Increase the Efficiency of Chemotherapy.	Folic Acid	0-6	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	48-52
34330116-0	2021	Activating Caspase-8/Bid/ROS Signaling to Promote Apoptosis of Breast Cancer Cells by Folate-modified Albumin Baicalin-loaded Nanoparticles.	Folic Acid	86-92	BH3 interacting domain death agonist	Homo sapiens	21-24
34319853-0	2021	Folate-methotrexate loaded bovine serum albumin nanoparticles preparation: an in vitro drug targeting cytokines overwhelming expressed immune cells from rheumatoid arthritis patients.	Folic Acid	0-6	albumin	Homo sapiens	34-47
34319853-1	2021	The study planned to estimate biological parameters linked to rheumatoid arthritis (RA) patients, detecting the influence of MTX and biotherapy treatments on these parameters and synthesizing methotrexate bovine serum albumin nanoparticles linked to folate (FA-MTX-BSA NPs) to reduce the overwhelming expression of inflammatory cytokines.	Folic Acid	250-256	albumin	Homo sapiens	212-225
34250253-7	2021	A significant correlation was noticed between PGA-IgA and CD4+ CXCR5+ Tfh cells (r = 0.380 and P = 0.042) and CD4+ CXCR5+ ICOS+ Tfh cells (r = 0.906 and P < 0.001).	Folic Acid	46-49	CD4 molecule	Homo sapiens	58-61
34234415-3	2021	Methods: Folate-conjugated beta-CD-polycaprolactone block copolymers were synthesized and characterized.	Folic Acid	9-15	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	27-34
34268314-14	2021	The developmental timing-specific and incoherent fluctuation among folate adducts and increased expression of mthfd1L in response to FD reflect the context-dependent regulation of folate-mediated one-carbon metabolism, endowing the larvae to prioritize the essential biochemical pathways for supporting the continuous growth in response to folate depletion.	Folic Acid	180-186	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like	Danio rerio	110-117
34268314-14	2021	The developmental timing-specific and incoherent fluctuation among folate adducts and increased expression of mthfd1L in response to FD reflect the context-dependent regulation of folate-mediated one-carbon metabolism, endowing the larvae to prioritize the essential biochemical pathways for supporting the continuous growth in response to folate depletion.	Folic Acid	340-346	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like	Danio rerio	110-117
34257824-8	2021	Finally, among vitamins, folic acid seems to play an important role in the chemoprevention of gastric carcinogenesis by enhancing gastric epithelial apoptosis in patients with premalignant lesions by significantly increased expression of p53.	Folic Acid	25-35	tumor protein p53	Homo sapiens	238-241
34202848-0	2021	Paclitaxel-Loaded Folate-Targeted Albumin-Alginate Nanoparticles Crosslinked with Ethylenediamine.	Folic Acid	18-24	albumin	Homo sapiens	34-41
34239439-4	2021	To explore these mechanisms, experimental AKI was induced by folic acid (FA) administration in young (3-months-old) and old (1-year-old) mice, and kidneys were evaluated in the early phase of AKI, at 48 h. Tubular damage score, KIM-1 expression, the recruitment of infiltrating immune cells (mainly neutrophils and macrophages) and proinflammatory gene expression were higher in AKI kidneys of old than of young mice.	Folic Acid	61-71	hepatitis A virus cellular receptor 1	Mus musculus	228-233
34167925-7	2021	PSMA is also expressed by other cancer cell types and is implicated in glutamate and folate metabolism.	Folic Acid	85-91	folate hydrolase 1	Homo sapiens	0-4
34093861-10	2021	Conclusions: Based on the results, we proposed a potential pathway for HGF or TGF-beta1-induced EMT of HCC cells: HGF or TGF-beta1 treatment of HCC cells can increase the expression of glycosyltransferase FUT8 to up-regulate the core-fucosylation of N-glycans on glycoproteins including the FOLR1; core-fucosylation on FOLR1 can then enhance the folate uptake capacity to finally promote the EMT progress of HCC cells.	Folic Acid	346-352	transforming growth factor beta 1	Homo sapiens	121-130
34611067-12	2021	CONCLUSION: There is a significant negative correlation between serum vitamin B12 and folic acid with homocysteine levels, especially in high-risk cardiovascular group.	Folic Acid	86-96	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	78-81
34113268-3	2021	Therefore, this study aimed to use genetic and metabolomic data to determine the relationship between folate pharmacogenomics, one-carbon metabolites, and insulin resistance as measured using the homeostatic model assessment for insulin resistance (HOMA-IR) as a marker of CVD.	Folic Acid	102-108	insulin	Homo sapiens	155-162
34113268-3	2021	Therefore, this study aimed to use genetic and metabolomic data to determine the relationship between folate pharmacogenomics, one-carbon metabolites, and insulin resistance as measured using the homeostatic model assessment for insulin resistance (HOMA-IR) as a marker of CVD.	Folic Acid	102-108	insulin	Homo sapiens	229-236
34093861-10	2021	Conclusions: Based on the results, we proposed a potential pathway for HGF or TGF-beta1-induced EMT of HCC cells: HGF or TGF-beta1 treatment of HCC cells can increase the expression of glycosyltransferase FUT8 to up-regulate the core-fucosylation of N-glycans on glycoproteins including the FOLR1; core-fucosylation on FOLR1 can then enhance the folate uptake capacity to finally promote the EMT progress of HCC cells.	Folic Acid	346-352	transforming growth factor beta 1	Homo sapiens	78-87
34169999-13	2021	CONCLUSION: We reported significant association between genetic alterations of folate metabolism (MTHFR, MTRR) and DNA repair mechanism (RAD54L) genes with the histopathological characteristics of the meningioma tumors.	Folic Acid	79-85	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	105-109
34895119-7	2021	RESULTS: In most patients, folic acid treatment normalized homocysteine levels and increased antioxidant enzyme activity (paraoxonase 1) and decreased sulfhydryl (SH) groups.	Folic Acid	27-37	paraoxonase 1	Homo sapiens	122-135
35429607-5	2022	Pre-treatment with folic acid, which has known neuroprotective and anti-inflammatory properties, ameliorated IL-6 effects on mitochondrial respiration and IFN-gamma effects on dendritic spine density.	Folic Acid	19-29	interleukin 6	Homo sapiens	109-113
35429607-5	2022	Pre-treatment with folic acid, which has known neuroprotective and anti-inflammatory properties, ameliorated IL-6 effects on mitochondrial respiration and IFN-gamma effects on dendritic spine density.	Folic Acid	19-29	interferon gamma	Homo sapiens	155-164
35429607-6	2022	These findings suggest distinct mechanisms for how fetal IL-6 and IFN-gamma exposure influence risk for neuropsychiatric disorders, and how folic acid can mitigate such risk.	Folic Acid	140-150	interleukin 6	Homo sapiens	57-61
35429607-6	2022	These findings suggest distinct mechanisms for how fetal IL-6 and IFN-gamma exposure influence risk for neuropsychiatric disorders, and how folic acid can mitigate such risk.	Folic Acid	140-150	interferon gamma	Homo sapiens	66-75
35490796-3	2022	This study further investigated the ability of the methyl group donors, S-adenosyl methionine (SAM) and folic acid, to prevent promoter hypomethylation that results in decreased mRNA expression of inflammatory genes (COX2, EGR1, and SOCS3), and a reduction in arsenic-induced oxidative and nitrative DNA damage in human lymphoblast cells.	Folic Acid	104-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	217-221
35434830-2	2022	Methionine synthase reductase (MTRR) is one of the main targets of MTX in the folate metabolic pathways.	Folic Acid	78-84	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	0-29
35434830-2	2022	Methionine synthase reductase (MTRR) is one of the main targets of MTX in the folate metabolic pathways.	Folic Acid	78-84	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	31-35
35533346-4	2022	folic-acid-conjugated bovine serum albumin (FA-BSA) has been used to engineer the surface of GOx@ZIF-8-l-Arg composite nanoparticles to enhance their specific recognition of tumor cells.	Folic Acid	0-10	albumin	Homo sapiens	29-42
35565057-11	2022	CMap-CTD database analyses indicated the expression levels of Tlr2, Ccl2, Cxcl10, Fas, Irf8, Socs3, Stat3, Gbp6, Casp1 and Syk could be reversed by folic acid.	Folic Acid	148-158	CTD	Homo sapiens	5-8
35565057-11	2022	CMap-CTD database analyses indicated the expression levels of Tlr2, Ccl2, Cxcl10, Fas, Irf8, Socs3, Stat3, Gbp6, Casp1 and Syk could be reversed by folic acid.	Folic Acid	148-158	toll like receptor 2	Homo sapiens	62-66
35565057-11	2022	CMap-CTD database analyses indicated the expression levels of Tlr2, Ccl2, Cxcl10, Fas, Irf8, Socs3, Stat3, Gbp6, Casp1 and Syk could be reversed by folic acid.	Folic Acid	148-158	signal transducer and activator of transcription 3	Homo sapiens	100-105
35565057-11	2022	CMap-CTD database analyses indicated the expression levels of Tlr2, Ccl2, Cxcl10, Fas, Irf8, Socs3, Stat3, Gbp6, Casp1 and Syk could be reversed by folic acid.	Folic Acid	148-158	caspase 1	Homo sapiens	113-118
35383339-7	2022	Compared with the placebo, folate supplementation significantly decreased plasma homocysteine (Hcy) levels (P < 0.001), serum insulin values (in the crude model) (P = 0.01), and homeostasis model assessment of insulin resistance (P = 0.01).	Folic Acid	27-33	insulin	Homo sapiens	126-133
35383339-7	2022	Compared with the placebo, folate supplementation significantly decreased plasma homocysteine (Hcy) levels (P < 0.001), serum insulin values (in the crude model) (P = 0.01), and homeostasis model assessment of insulin resistance (P = 0.01).	Folic Acid	27-33	insulin	Homo sapiens	210-217
35383339-8	2022	Also, folate supplementation resulted in a significant improvement in the quantitative insulin sensitivity check index (P = 0.002) and total antioxidant capacity (P = 0.04) and a significant reduction in high-sensitivity C-reactive protein (P = 0.015) in comparison with the placebo group.	Folic Acid	6-12	insulin	Homo sapiens	87-94
35383339-8	2022	Also, folate supplementation resulted in a significant improvement in the quantitative insulin sensitivity check index (P = 0.002) and total antioxidant capacity (P = 0.04) and a significant reduction in high-sensitivity C-reactive protein (P = 0.015) in comparison with the placebo group.	Folic Acid	6-12	C-reactive protein	Homo sapiens	221-239
35383339-9	2022	CONCLUSIONS: In conclusion, folate supplementation for 12 weeks among overweight/obese women with CIN2/3 showed a non-significant decrease in its recurrence and had beneficial effects on insulin sensitivity, inflammation, and oxidative stress markers.	Folic Acid	28-34	insulin	Homo sapiens	187-194
35190897-0	2022	Folate ameliorates homocysteine-induced osteoblast dysfunction by reducing endoplasmic reticulum stress-activated PERK/ATF-4/CHOP pathway in MC3T3-E1 cells.	Folic Acid	0-6	activating transcription factor 4	Mus musculus	119-124
35417465-0	2022	The regulation of HBP1, SIRT1, and SREBP-1c genes and the related microRNAs in non-alcoholic fatty liver rats: The association with the folic acid anti-steatosis.	Folic Acid	136-146	HMG-box transcription factor 1	Rattus norvegicus	18-22
35417465-0	2022	The regulation of HBP1, SIRT1, and SREBP-1c genes and the related microRNAs in non-alcoholic fatty liver rats: The association with the folic acid anti-steatosis.	Folic Acid	136-146	sirtuin 1	Rattus norvegicus	24-29
35417465-3	2022	Our current work aimd to explore the possible ameliorative potency of folic acid and its association with the hepatic miR-21, -34a, and -122 expression as well as their targeted genes, HBP1, SIRT1, and SREBP-1c in rats with non-alcoholic fatty liver disease (NAFL).	Folic Acid	70-80	HMG-box transcription factor 1	Rattus norvegicus	185-189
35417465-3	2022	Our current work aimd to explore the possible ameliorative potency of folic acid and its association with the hepatic miR-21, -34a, and -122 expression as well as their targeted genes, HBP1, SIRT1, and SREBP-1c in rats with non-alcoholic fatty liver disease (NAFL).	Folic Acid	70-80	sirtuin 1	Rattus norvegicus	191-196
35417465-11	2022	In conclusions, the anti-steatotic, insulin-sensitizing, glucose-lowering and lipotropic potencies of folic acid in NAFL rats may be linked to the epigenetic modulation of the hepatic microRNAs (miR-21, -34a, and -122) and the expression of their target genes (HBP1, SIRT1, and SREBP-1c).	Folic Acid	102-112	HMG-box transcription factor 1	Rattus norvegicus	261-265
35417465-11	2022	In conclusions, the anti-steatotic, insulin-sensitizing, glucose-lowering and lipotropic potencies of folic acid in NAFL rats may be linked to the epigenetic modulation of the hepatic microRNAs (miR-21, -34a, and -122) and the expression of their target genes (HBP1, SIRT1, and SREBP-1c).	Folic Acid	102-112	sirtuin 1	Rattus norvegicus	267-272
35019930-4	2022	Specifically, the tumor-targeting molecule folate-poly (ethylene glycol) (FA-PEG) was modified with a zwitterionic 2-(methyl acryloyoxy) ethyl choline phosphate (MCP) by the Michael addition reaction to obtain MCP-modified FA-PEG (MCP-PEG-FA).	Folic Acid	43-49	CD46 molecule	Homo sapiens	162-165
35019930-4	2022	Specifically, the tumor-targeting molecule folate-poly (ethylene glycol) (FA-PEG) was modified with a zwitterionic 2-(methyl acryloyoxy) ethyl choline phosphate (MCP) by the Michael addition reaction to obtain MCP-modified FA-PEG (MCP-PEG-FA).	Folic Acid	43-49	CD46 molecule	Homo sapiens	210-213
35019930-4	2022	Specifically, the tumor-targeting molecule folate-poly (ethylene glycol) (FA-PEG) was modified with a zwitterionic 2-(methyl acryloyoxy) ethyl choline phosphate (MCP) by the Michael addition reaction to obtain MCP-modified FA-PEG (MCP-PEG-FA).	Folic Acid	43-49	CD46 molecule	Homo sapiens	231-234
35385727-6	2022	Mechanistically, the MTHFD1-mediated folate cycle regulates NADPH homeostasis to promote leukemogenesis and methotrexate resistance.	Folic Acid	37-43	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	21-27
35179085-0	2022	Transferrin/Folate Dual-Targeting Pluronic F127/Poly(lactic acid) Polymersomes for Effective Anticancer Drug Delivery.	Folic Acid	12-18	transferrin	Homo sapiens	0-11
35316219-6	2022	Lastly, we found that topical treatment with AhR antagonists vitamin B12 and folic acid ameliorated UVB-induced wrinkle formation in mice while dampening MMP2 expression in the skin.	Folic Acid	77-87	aryl-hydrocarbon receptor	Mus musculus	45-48
35513392-6	2022	One GxE interaction hit illustrates that the fitness defect in the mitochondrial folate carrier (SLC25A32) KO cells is genetically buffered in galactose due to a lack of substrate in de novo purine biosynthesis.	Folic Acid	81-87	solute carrier family 25 member 32	Homo sapiens	97-105
35489763-1	2022	BACKGROUND/AIM: 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR) is responsible for folate metabolism, and we aimed to investigate its genetic role in colorectal cancer (CRC) among Taiwanese.	Folic Acid	108-114	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	54-81
35489763-1	2022	BACKGROUND/AIM: 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR) is responsible for folate metabolism, and we aimed to investigate its genetic role in colorectal cancer (CRC) among Taiwanese.	Folic Acid	108-114	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	83-87
35139535-9	2022	Finally, folic acid (FA) significantly attenuated aortic valve calcification in WD-fed Apoe-/- mice through increasing DHFR and salvaging BH4 biosynthesis.	Folic Acid	9-19	apolipoprotein E	Mus musculus	87-91
35349697-0	2022	Deacetylation of MTHFD2 by SIRT4 senses stress signal to inhibit cancer cell growth by remodeling folate metabolism.	Folic Acid	98-104	sirtuin 4	Homo sapiens	27-32
35123312-5	2022	Cumulus expansion markers (PTX3 and PTGS2) in cumulus cells were highly upregulated after 50 muM folic acid supplementation indicating higher degree of maturation.	Folic Acid	97-107	pentraxin 3	Homo sapiens	27-31
35123312-5	2022	Cumulus expansion markers (PTX3 and PTGS2) in cumulus cells were highly upregulated after 50 muM folic acid supplementation indicating higher degree of maturation.	Folic Acid	97-107	prostaglandin-endoperoxide synthase 2	Homo sapiens	36-41
35558981-0	2022	Early supplementation of folate and vitamin B12 improves insulin resistance in intrauterine growth retardation rats.	Folic Acid	25-31	insulin	Homo sapiens	57-64
35558981-3	2022	We aimed to investigate the effects of supplementation with high folate and vitamin B12 diets in the early postnatal period on the changes in insulin sensitivity in an intrauterine growth retardation (IUGR) rat model.	Folic Acid	65-71	insulin	Homo sapiens	142-149
35558981-15	2022	Conclusions: Early supplementation of folate and vitamin B12 improved insulin resistance and lipid levels in IUGR rats to some extent, along with decreasing homocysteine levels, but not enough to completely repair glucose and lipid metabolism.	Folic Acid	38-44	insulin	Homo sapiens	70-77
35349697-8	2022	Collectively, our study reveals that SIRT4 senses folate availability to control MTHFD2 K50 acetylation and its protein stability, bridging nutrient/folate stress and cellular redox to act on cancer cell growth.	Folic Acid	50-56	sirtuin 4	Homo sapiens	37-42
35349697-8	2022	Collectively, our study reveals that SIRT4 senses folate availability to control MTHFD2 K50 acetylation and its protein stability, bridging nutrient/folate stress and cellular redox to act on cancer cell growth.	Folic Acid	149-155	sirtuin 4	Homo sapiens	37-42
35322363-0	2022	Folic acid alleviates lead acetate-mediated cardiotoxicity by down-regulating the expression levels of Nrf2, HO-1, GRP78, and CHOP proteins.	Folic Acid	0-10	NFE2 like bZIP transcription factor 2	Rattus norvegicus	103-107
35356087-6	2022	Pathway analysis showed that T-allele of rs1801133 could inhibit the expression of PPARG through the downregulation of folate levels and upregulation of Hcy levels, which increased the risk of hypertension and hyperhomocysteinemia.	Folic Acid	119-125	peroxisome proliferator activated receptor gamma	Homo sapiens	83-88
2500271-2	1989	In an epileptic boy undergoing long-term treatment with valproic acid (VPA), 1.3 g/d, CBMZP, 0.9 g/d and folic acid, 7.5 mg/d, decreased activities of ALA-D and URO-S coincided with increased levels of erythrocyte protoporphyrin (EP) in the absence of Pb poisoning, iron depletion and erythropoietic protoporphyria.	Folic Acid	105-115	hydroxymethylbilane synthase	Homo sapiens	161-166
35140550-1	2022	The stereoisomeric system of rac-2-phenylglycinamide (PGA) and rac-N-acetyl tryptophan (NAT) is significant in the application of chiral resolution because it has been shown that this system can be used for enantioseparation of PGA and/or NAT using a novel deracemization route of the conglomerate salt formed.	Folic Acid	54-57	Rac family small GTPase 2	Homo sapiens	29-34
35140550-1	2022	The stereoisomeric system of rac-2-phenylglycinamide (PGA) and rac-N-acetyl tryptophan (NAT) is significant in the application of chiral resolution because it has been shown that this system can be used for enantioseparation of PGA and/or NAT using a novel deracemization route of the conglomerate salt formed.	Folic Acid	228-231	Rac family small GTPase 2	Homo sapiens	29-34
35140550-1	2022	The stereoisomeric system of rac-2-phenylglycinamide (PGA) and rac-N-acetyl tryptophan (NAT) is significant in the application of chiral resolution because it has been shown that this system can be used for enantioseparation of PGA and/or NAT using a novel deracemization route of the conglomerate salt formed.	Folic Acid	228-231	Rac family small GTPase 2	Homo sapiens	63-66
35126516-2	2022	Folate modified albumin was used to enhance the targeting potential of the prepared microspheres.	Folic Acid	0-6	albumin	Homo sapiens	16-23
35126516-7	2022	It is worth noting that incorporation of Nintedanib into folic acid modified albumin microspheres resulted in an enhanced uptake of the drug into MCF-7 breast cancer cells coupled with higher inhibition rate.	Folic Acid	57-67	albumin	Homo sapiens	77-84
35126516-8	2022	Altogether, incorporation of Nintedanib into folate modified albumin microspheres is a new approach to improve water solubility and targeting effect of the drug.	Folic Acid	45-51	albumin	Homo sapiens	61-68
34601603-0	2022	Vitamin B12 and Folate Markers are Associated with Insulin Resistance During the Third Trimester of Pregnancy In South Asian Women, Living in the UK, With Gestational Diabetes and Normal Glucose Tolerance.	Folic Acid	16-22	insulin	Homo sapiens	51-58
35013550-1	2022	Putative tumor suppressor ALDH1L1, the product of natural fusion of three unrelated genes, regulates folate metabolism by catalyzing NADP+-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and CO2.	Folic Acid	101-107	aldehyde dehydrogenase 1 family, member L1	Rattus norvegicus	26-33
35125691-10	2022	In addition, presence of low folate, and hyperhomocysteinemia was observed in the present study, may be the contributing factors for the hypomethylation of IL-6 and TNF-alpha and oxidative stress.	Folic Acid	29-35	interleukin 6	Homo sapiens	156-160
35337631-3	2022	Few mechanisms that underlie the neuropsychiatric manifestations of B12 deficiency include alteration in one-carbon metabolism, genetic vulnerability, and alteration in folate metabolism.	Folic Acid	169-175	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	68-71
35370749-3	2022	In this study, the anti-inflammatory effects of FOL and its mechanisms on PI3K/AKT and NF-kappaB signaling pathways in LPS-induced RAW264.7 cells were explored, as well as the regulatory effect of FOL on apoptosis.	Folic Acid	48-51	thymoma viral proto-oncogene 1	Mus musculus	79-82
35370749-7	2022	In LPS-induced ALI mice, FOL administration showed inhibition of IL-1beta, IL-6, and TNF-alpha in Bronchoalveolar lavage fluid (BALF) and decreased protein expression levels of PI3K, AKT, NF-kappaB p50, and NF-kappaB p65, and elevated protein expression levels of Bax and cleaved-caspase-3 significantly.	Folic Acid	25-28	interleukin 6	Mus musculus	75-79
35370749-7	2022	In LPS-induced ALI mice, FOL administration showed inhibition of IL-1beta, IL-6, and TNF-alpha in Bronchoalveolar lavage fluid (BALF) and decreased protein expression levels of PI3K, AKT, NF-kappaB p50, and NF-kappaB p65, and elevated protein expression levels of Bax and cleaved-caspase-3 significantly.	Folic Acid	25-28	tumor necrosis factor	Mus musculus	85-94
35370749-7	2022	In LPS-induced ALI mice, FOL administration showed inhibition of IL-1beta, IL-6, and TNF-alpha in Bronchoalveolar lavage fluid (BALF) and decreased protein expression levels of PI3K, AKT, NF-kappaB p50, and NF-kappaB p65, and elevated protein expression levels of Bax and cleaved-caspase-3 significantly.	Folic Acid	25-28	thymoma viral proto-oncogene 1	Mus musculus	183-186
35370749-7	2022	In LPS-induced ALI mice, FOL administration showed inhibition of IL-1beta, IL-6, and TNF-alpha in Bronchoalveolar lavage fluid (BALF) and decreased protein expression levels of PI3K, AKT, NF-kappaB p50, and NF-kappaB p65, and elevated protein expression levels of Bax and cleaved-caspase-3 significantly.	Folic Acid	25-28	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	188-201
35126709-8	2022	Western blotting demonstrated that the expression levels of ERbeta and the phosphorylation levels of PI3K and AKT were decreased, whilst the expression levels of cleaved caspase-3 were increased, in the cerebral cortex of female mice that received folate-deficient diet.	Folic Acid	248-254	thymoma viral proto-oncogene 1	Mus musculus	110-113
35233817-11	2022	CONCLUSION: Lower masticatory performance, lower SSF and fewer teeth were associated with a lower intake of several micronutrients, such as vitamin A, beta-carotene and folic acids, in Japanese individuals of advanced age.	Folic Acid	169-180	amyloid beta precursor protein	Homo sapiens	90-91
35280255-7	2021	Specifically, FG-4592 pretreatment inhibited hypoxia inducible factor-1alpha activation on the 7th day after folic acid injection, which ameliorated ultrastructural abnormalities, promoted ATP production, and attenuated excessive reactive oxygen species production both in renal tissue and mitochondria.	Folic Acid	109-119	hypoxia inducible factor 1 subunit alpha	Homo sapiens	45-76
35242798-2	2022	The study aims to investigate the efficacy of a blend of docosahexaenoic acid (DHA), arachidonic acid (ARA), iron, vitamin B12, folic acid, and sphingomyelin (SM) from a uniquely processed whey protein concentrate enriched in alpha-lactalbumin and phospholipids compared with a control formulation on myelination, cognitive, and behavioral development in the first 6 months of life.	Folic Acid	128-138	lactalbumin alpha	Homo sapiens	226-243
35126516-0	2022	Preparation and Study of Folate Modified Albumin Targeting Microspheres.	Folic Acid	25-31	albumin	Homo sapiens	41-48
35126516-1	2022	In this study, folate modified bovine serum albumin was successfully synthesized, while preparation of Nintedanib albumin microspheres (ND-FSA NPs) as a carrier was carried out via electrospinning technology.	Folic Acid	15-21	albumin	Homo sapiens	38-51
35021051-1	2022	The role of folate-dependent one carbon (1C) metabolism in CD4+ T cell polarization is incompletely understood.	Folic Acid	12-18	CD4 molecule	Homo sapiens	59-62
2478370-4	1989	After correction of A-V differences for diuresis with the A-V difference of transferrin, GSCs (+/- SEM) for PGA and PGC were 0.90 +/- 0.14 and 0.85 +/- 0.17, respectively, GSC of beta 2-microglobulin being 0.90 +/- 0.12.	Folic Acid	108-111	transferrin	Homo sapiens	76-87
2638194-3	1989	A highly significant positive correlation (P less than 0.01) between folic acid and B12 levels was observed both in thalassemic patients (r = 0.93) and in the controls (r = 0.97).	Folic Acid	69-79	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	84-87
2633609-1	1989	Growth of rat hepatoma cells in subtoxic concentrations of the DHFR inhibitor metoprine caused a marked time and concentration dependent reduction in cellular folates.	Folic Acid	159-166	dihydrofolate reductase	Rattus norvegicus	63-67
3066463-3	1988	Treating a B12 deficient patient with folate or conversely a folate deficient patient with B12 may exacerbate the neurologic consequences of either deficiency.	Folic Acid	38-44	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	11-14
3066463-3	1988	Treating a B12 deficient patient with folate or conversely a folate deficient patient with B12 may exacerbate the neurologic consequences of either deficiency.	Folic Acid	61-67	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	91-94
2969513-5	1988	On admission, there was a significant correlation between folate status, severity index and serum albumin and transferrin, all variables which reflect the patient"s nutritional status.	Folic Acid	58-64	albumin	Homo sapiens	98-105
3403518-11	1988	Eight of the nine pairs of cysteines involved in disulfide bonds in RfBP are conserved in folate-binding protein, as are all of the tryptophan residues.	Folic Acid	90-96	riboflavin binding protein	Gallus gallus	68-72
3385770-1	1988	An L1210 cell line (JT-1), which can grow in medium supplemented with 1 nM folate, has been isolated.	Folic Acid	75-81	I-J antigen expression	Mus musculus	20-24
3338799-4	1988	Out of 17 rare autosomal fragile sites defined in HGM8, the following six were identified in Japan; folate-sensitive fra(2)(q11), fra(11)(q13) and fra(11)(q23), distamycin A-inducible fra(16)(q22) and fra(17)(p12), and BrdU-requiring fra(10)(q25).	Folic Acid	100-106	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	209-212
3338799-6	1988	Furthermore, a folate-sensitive fra(17)(p12) and a distamycin A-inducible fra(8)(q24.1) have been newly found in the present study.	Folic Acid	15-21	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	40-43
3338799-8	1988	Since the expression of this fra(17)(p12) was induced by fluorodeoxyuridine, suppressed by thymidine, but not induced by distamycin A, it can be classified as a folate-sensitive site.	Folic Acid	161-167	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	37-40
3124478-0	1988	Effect of therapy with vitamin B12 and folic acid on elderly patients with low concentrations of serum vitamin B12 or erythrocyte folate but normal blood counts.	Folic Acid	39-49	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	111-114
3662711-2	1987	The major drawback to indiscriminate folate therapy is the potential of masking findings of vitamin B12 (cobalamin) deficiency.	Folic Acid	37-43	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	100-103
3405341-8	1988	In order to eliminate the possibility of influencing the cytostatic activity of the derivative with byproducts of its synthesis, human serum albumin-folic acid derivative (HSA-FA) was prepared and tested by the same method.	Folic Acid	149-159	albumin	Homo sapiens	135-148
2828540-0	1987	Hydroperoxide-dependent folic acid degradation by cytochrome c.	Folic Acid	24-34	cytochrome c, somatic	Homo sapiens	50-62
2828540-1	1987	Folic acid is degraded by cytochrome c in the presence of hydrogen peroxide/tert-butyl hydroperoxide at the C9-N10 bond.	Folic Acid	0-10	cytochrome c, somatic	Homo sapiens	26-38
2828540-4	1987	Catalase, formate, and thiourea inhibited hydrogen peroxide-dependent folic acid degradation only, and not tert-butyl hydroperoxide dependent degradation.	Folic Acid	70-80	catalase	Homo sapiens	0-8
2828540-7	1987	The mechanism of cytochrome c-catalyzed folic acid degradation is discussed.	Folic Acid	40-50	cytochrome c, somatic	Homo sapiens	17-29
3653370-2	1987	After vitamin B12 treatment, a peak whole blood folate value some 70% higher than the starting value was noted after about 75 d in patients treated with B12 injections and after about 165 d in perorally treated patients.	Folic Acid	48-54	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	14-17
3630970-0	1987	Competitive inhibition of folate absorption by dihydrofolate reductase inhibitors, trimethoprim and pyrimethamine.	Folic Acid	26-32	dihydrofolate reductase	Rattus norvegicus	47-70
3630970-5	1987	[3H] folic acid absorption from jejunal loops was determined 3-16 h after IV administration of methotrexate; this treatment abolished DHFR activity in the small intestine.	Folic Acid	5-15	dihydrofolate reductase	Rattus norvegicus	134-138
3653370-2	1987	After vitamin B12 treatment, a peak whole blood folate value some 70% higher than the starting value was noted after about 75 d in patients treated with B12 injections and after about 165 d in perorally treated patients.	Folic Acid	48-54	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	153-156
2434548-1	1987	We tested the hypothesis that patients who experience immediate hypersensitivity reactions to sulfonamides (SM) express IgE that can bind to a N4-sulfonamidoyl determinant (N4-SM).	Folic Acid	143-145	immunoglobulin heavy constant epsilon	Homo sapiens	120-123
3812977-1	1986	The enzyme folylpolyglutamate synthetase (FPGS) catalyzes the conversion of folate (pteroylmonoglutamate) to the polyglutamate forms (pteroylpolyglutamates) that are required for folate retention by mammalian cells.	Folic Acid	76-82	folylpolyglutamate synthase, mitochondrial	Cricetulus griseus	11-40
3812977-1	1986	The enzyme folylpolyglutamate synthetase (FPGS) catalyzes the conversion of folate (pteroylmonoglutamate) to the polyglutamate forms (pteroylpolyglutamates) that are required for folate retention by mammalian cells.	Folic Acid	84-104	folylpolyglutamate synthase, mitochondrial	Cricetulus griseus	11-40
3812977-1	1986	The enzyme folylpolyglutamate synthetase (FPGS) catalyzes the conversion of folate (pteroylmonoglutamate) to the polyglutamate forms (pteroylpolyglutamates) that are required for folate retention by mammalian cells.	Folic Acid	179-185	folylpolyglutamate synthase, mitochondrial	Cricetulus griseus	11-40
3812977-5	1986	In contrast, FPGS in wild-type Chinese hamster CHO cells causes folate retention and enables the incorporation of [6-3H]deoxyuridine into DNA.	Folic Acid	64-70	folylpolyglutamate synthase, mitochondrial	Cricetulus griseus	13-17
2946653-3	1986	This increase in Pdi was essentially due to an increase in Ppl, since Pga and EMGdi had a linear relationship (r = 0.98, P less than 0.001) that did not change during the occlusive and ventilatory phases.	Folic Acid	70-73	periplakin	Homo sapiens	59-62
3466358-1	1986	Chinese hamster AUX B1 cells lack the enzyme folylpolyglutamate synthetase (FPGS) responsible for adding polyglutamates to folic acid.	Folic Acid	123-133	folylpolyglutamate synthase, mitochondrial	Cricetulus griseus	45-74
3466358-1	1986	Chinese hamster AUX B1 cells lack the enzyme folylpolyglutamate synthetase (FPGS) responsible for adding polyglutamates to folic acid.	Folic Acid	123-133	folylpolyglutamate synthase, mitochondrial	Cricetulus griseus	76-80
3091098-5	1986	We also measured the activities of another three enzymes of the folic acid cycle, viz., 5,10-methylene-H4folate dehydrogenase, 10-formyl-H4folate synthetase, and 5,10-methenyl-H4folate cyclohydrolase, as well as the enzyme cystathionine beta-synthase.	Folic Acid	64-74	cystathionine beta-synthase	Homo sapiens	223-250
3676170-11	1986	The hepatic activity of another key folate-metabolizing enzyme, dihydrofolate reductase (EC 1.5.1.3), was not diminished by riboflavin deficiency in the present study.	Folic Acid	36-42	dihydrofolate reductase	Rattus norvegicus	64-87
3540926-10	1986	Patients with dihydropteridine reductase (DHPR) deficiency accumulate dihydrobiopterins and develop secondary folate deficiency which resembles that occurring in patients with defective 5,10-methylene tetrahydrofolate reductase activity.	Folic Acid	110-116	quinoid dihydropteridine reductase	Homo sapiens	14-40
3540926-10	1986	Patients with dihydropteridine reductase (DHPR) deficiency accumulate dihydrobiopterins and develop secondary folate deficiency which resembles that occurring in patients with defective 5,10-methylene tetrahydrofolate reductase activity.	Folic Acid	110-116	quinoid dihydropteridine reductase	Homo sapiens	42-46
6490627-1	1984	Dimethylglycine dehydrogenase (EC 1.5.99.2) and sarcosine dehydrogenase (EC 1.5.99.1) are the folate binding proteins of rat liver mitochondria.	Folic Acid	94-100	sarcosine dehydrogenase	Rattus norvegicus	48-71
6602086-4	1983	This so-called methyl-folate-trap results in a functional folic acid deficiency which is the pathogenetic principle of the defect in the cell proliferation in patients with vitamin B12 deficiency.	Folic Acid	58-68	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	181-184
6738364-5	1984	The specific activity of galactose-1-phosphate uridyltransferase was elevated in livers of the folate group compared to the controls perfused with either galactose or glucose.	Folic Acid	95-101	galactose-1-phosphate uridylyltransferase	Rattus norvegicus	25-64
6500843-0	1984	Quantitative and qualitative effects of N10-methylfolate on high-affinity folate binding in human leukocytes.	Folic Acid	50-56	nuclear receptor subfamily 4 group A member 1	Homo sapiens	40-43
6500843-2	1984	Furthermore, folate binding changed into a non-cooperative type in the presence of N10-methylfolate.	Folic Acid	13-19	nuclear receptor subfamily 4 group A member 1	Homo sapiens	83-86
6599862-14	1983	Although folic acid is intimately related biochemically and nutritionally to vitamin B12, its potential role in normal mental function remains largely unknown.	Folic Acid	9-19	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	85-88
6977386-5	1982	In both, N6-formyl tetrahydrofolate (formyl-FH4) was the most effective agent at correcting thymidylate synthesis in megaloblastic anemia due to vitamin B12 or folate deficiency.	Folic Acid	29-35	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	153-156
6977386-7	1982	Tetrahydrofolate (FH4) and folic acid were effective in deficiency of vitamin B12 or folate, although in both deficiencies they were less effective than formyl-FH4.	Folic Acid	27-37	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	78-81
6977386-7	1982	Tetrahydrofolate (FH4) and folic acid were effective in deficiency of vitamin B12 or folate, although in both deficiencies they were less effective than formyl-FH4.	Folic Acid	10-16	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	78-81
7432462-5	1980	Secondary isotope effects were also observed on ion-exchange chromatography, 3H-labelled folates with 3H at the C-9 position eluting fractionally earlier than the corresponding unlabelled or [2-14C]folate from DEAE-cellulose, a behaviour similar to that reported earlier for isotopically labelled 2-aminopurine and several amino acids.	Folic Acid	89-96	complement C9	Rattus norvegicus	112-115
6270515-0	1981	Neurotoxicity of folates: implications for vitamin B12 deficiency and Huntington"s chorea.	Folic Acid	17-24	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	51-54
6112249-1	1981	SASP, the drug most widely used for the treatment of Crohn"s disease and ulcerative colitis, is a competitive inhibitor of intestinal folate metabolism and transport.	Folic Acid	134-140	aspartic peptidase retroviral like 1	Homo sapiens	0-4
6112249-3	1981	Experiments were designed to examine the effect of SASP on folate-dependent systems in cultured lymphocytes.	Folic Acid	59-65	aspartic peptidase retroviral like 1	Homo sapiens	51-55
6112249-7	1981	SASP inhibited the folate-dependent pathway in proliferating virally transformed human lymphocytes (Raji cells).	Folic Acid	19-25	aspartic peptidase retroviral like 1	Homo sapiens	0-4
6112249-8	1981	To confirm that SASP acts as a folate antagonist in this system, THF was demonstrated to partly reverse the action of SASP.	Folic Acid	31-37	aspartic peptidase retroviral like 1	Homo sapiens	16-20
6164371-0	1981	The effect of nitrous oxide-induced vitamin B12 deficiency on in vivo folate metabolism.	Folic Acid	70-76	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	44-47
7410436-1	1980	Formiminotransferase-cyclodeaminase, an octameric protein of identical, bifunctional polypeptides of Mr = 62,000, yields a transferase-active fragment of Mr = 80,000 upon proteolysis with chymotrypsin in the presence of the inhibitor folic acid.	Folic Acid	234-244	formimidoyltransferase cyclodeaminase	Homo sapiens	0-35
761221-5	1979	The presence of DHFR in neoplasms of central nervous system origin is relevant to the development of folate antagonists which, unlike methotrexate, can readily cross the blood-brain barrier.	Folic Acid	101-107	dihydrofolate reductase	Rattus norvegicus	16-20
6934068-1	1980	An auxotrophic mutant, GAT-, derived from the Chinese hamster cell line CHO-K1 and exhibiting multiple growth requirements for glycine, adenine, and thymidine, has been shown to be deficient in one of the folate-dependent enzymes, folylpolyglutamate synthetase (FPGS).	Folic Acid	205-211	folylpolyglutamate synthase, mitochondrial	Cricetulus griseus	231-260
6934068-1	1980	An auxotrophic mutant, GAT-, derived from the Chinese hamster cell line CHO-K1 and exhibiting multiple growth requirements for glycine, adenine, and thymidine, has been shown to be deficient in one of the folate-dependent enzymes, folylpolyglutamate synthetase (FPGS).	Folic Acid	205-211	folylpolyglutamate synthase, mitochondrial	Cricetulus griseus	262-266
398128-3	1979	B12 is thereby inactivated and this interferes with folate metabolism and thymidine synthesis: the effect may be detected after only a few hours in vivo exposure of mammals to 50% nitrous oxide.	Folic Acid	52-58	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	0-3
666858-0	1978	The effect of vitamin B12 inhibition in vivo: impaired folate polyglutamate biosynthesis indicating that 5-methyltetrahydropteroylglutamate is not its usual substrate.	Folic Acid	55-61	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	22-25
309336-5	1978	Among 16 patients with subnormal serum levels of both vitamin B12 and folate, vitamin B12 partially corrected the test in eight, including all five with pernicious anaemia, but had no effect in the other eight.	Folic Acid	70-76	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	86-89
647462-4	1978	Folic acid levels in the serum tended to be high when the vitamin B12 level was low (r = 0.29).	Folic Acid	0-10	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	66-69
707871-0	1978	[Interrelations between folates and vitamin B12 (proceedings)].	Folic Acid	24-31	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	44-47
849481-6	1977	Vitamin B-12 deficiency can lead to lowered levels of 5-methyltetrahydrofolate:homocysteine methyltransferase, creating a functional folate deficiency by "trapping" an increased proportion of folate as the methyl derivative.	Folic Acid	133-139	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	54-109
1247496-5	1976	The failure of folate polyglutamate synthesis in ivtamin B12 deficiency arises either from a failure to provide the proper substrate for polyglutamate synthesis or to a direct requirement for vitamin B12 for polyglutamate synthesis.	Folic Acid	15-21	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	57-60
1201264-1	1975	The induction of vitamin B12 deficiency and its effect on folate levels.	Folic Acid	58-64	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	25-28
13539482-0	1958	The effect of pteroylglutamic acid administration on the serum vitamin B12 concentration in pernicious anemia in relapse.	Folic Acid	14-34	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	71-74
5070373-0	1972	Plasma renin activity in folic acid induced acute renal failure.	Folic Acid	25-35	renin	Homo sapiens	7-12
4628983-0	1972	Transferrin, the third carrier protein of folic acid activity in human serum.	Folic Acid	42-52	transferrin	Homo sapiens	0-11
5412676-0	1970	Erythrocyte vitamin B12 activity in health, polycythemia, and in deficiency of vitamin B12 and folate.	Folic Acid	95-101	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	20-23
4981420-0	1969	Effects of dietary methionine and vitamin B12 deficiency on folate metabolism.	Folic Acid	60-66	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	42-45
5739917-0	1968	[Study of the folic acid content in human and bovine milk].	Folic Acid	14-24	Weaning weight-maternal milk	Bos taurus	53-58
13295665-0	1956	Supplemental folic acid therapy in pernicious anemia:  the effect on erythropoiesis and serum vitamin B12 concentrations in selected cases.	Folic Acid	13-23	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	102-105
13255343-0	1955	Catalase activity of erythrocytes from folic acid deficient rats.	Folic Acid	39-49	catalase	Rattus norvegicus	0-8
14379605-0	1954	[Reinforcement of the action of growth hormone by folic acid and vitamin B12].	Folic Acid	50-60	growth hormone 1	Homo sapiens	32-46
13246252-0	1954	[Potentiation of the growth hormone by folic acid or vitamin B12].	Folic Acid	39-49	growth hormone 1	Homo sapiens	21-35
18899767-0	1948	The effect of folic acid analogues on the action of dopa decarboxylase.	Folic Acid	14-24	dopa decarboxylase	Homo sapiens	52-70
33517500-8	2021	Folate values were significantly lower with age (p < 0.01), low NSE and low parental educational level (p: 0.0001).	Folic Acid	0-6	enolase 2	Homo sapiens	64-67
33745894-4	2021	MATERIALS AND METHODS: We used pegylated chitosan lactate nanoparticles (NPs) functionalized by TAT peptide and folate to deliver STAT3 siRNA and DOX to cancer cells simultaneously, both in vitro and in vivo.	Folic Acid	112-118	signal transducer and activator of transcription 3	Homo sapiens	130-135
33400181-8	2021	Our bioinformatics analysis revealed that the oxidative stress genes superoxide dismutase (SOD1, SOD2) and the pro-inflammatory marker tumor necrosis factor (TNF) were identified as the top relevant genes, and the folate metabolism, vitamin B12 metabolism, and the ALS pathways were highly affected by formaldehyde and related to the most brain diseases of interest.	Folic Acid	214-220	superoxide dismutase 1	Homo sapiens	91-95
33400181-8	2021	Our bioinformatics analysis revealed that the oxidative stress genes superoxide dismutase (SOD1, SOD2) and the pro-inflammatory marker tumor necrosis factor (TNF) were identified as the top relevant genes, and the folate metabolism, vitamin B12 metabolism, and the ALS pathways were highly affected by formaldehyde and related to the most brain diseases of interest.	Folic Acid	214-220	tumor necrosis factor	Homo sapiens	135-156
33400181-8	2021	Our bioinformatics analysis revealed that the oxidative stress genes superoxide dismutase (SOD1, SOD2) and the pro-inflammatory marker tumor necrosis factor (TNF) were identified as the top relevant genes, and the folate metabolism, vitamin B12 metabolism, and the ALS pathways were highly affected by formaldehyde and related to the most brain diseases of interest.	Folic Acid	214-220	tumor necrosis factor	Homo sapiens	158-161
33829277-5	2021	Homozygous deletion of the Mthfd1l gene in mice (Mthfd1lz/z) causes embryonic lethality, developmental delay, and folate-resistant NTDs.	Folic Acid	114-120	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like	Mus musculus	27-34
34025417-0	2021	Ibudilast Attenuates Folic Acid-Induced Acute Kidney Injury by Blocking Pyroptosis Through TLR4-Mediated NF-kappaB and MAPK Signaling Pathways.	Folic Acid	21-31	toll-like receptor 4	Mus musculus	91-95
34025417-0	2021	Ibudilast Attenuates Folic Acid-Induced Acute Kidney Injury by Blocking Pyroptosis Through TLR4-Mediated NF-kappaB and MAPK Signaling Pathways.	Folic Acid	21-31	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	105-114
33309681-0	2021	Study on the Influencing Factors of Hypoglycemic Effect of Folate Targeted Polymersomes Encapsulating Insulin.	Folic Acid	59-65	insulin	Homo sapiens	102-109
33979572-4	2021	Studies investigating the mechanism revealed that PGA diminished the binding efficiency of ETS family of transcription factor (ELK1) and Serum response factor (SRF), and suppressed ELK1-SRF complex-dependent transcription, which decreased the transcriptional levels of downstream genes Early growth response protein 1 (EGR1)-Polycomb ring finger (BMI1), thus inducing the imbalanced regulation between Myeloid cell leukaemia-1 (MCL1) and F-Box and WD repeat domain containing 7 (FBXW7).	Folic Acid	50-53	F-box and WD repeat domain containing 7	Homo sapiens	438-477
33979572-4	2021	Studies investigating the mechanism revealed that PGA diminished the binding efficiency of ETS family of transcription factor (ELK1) and Serum response factor (SRF), and suppressed ELK1-SRF complex-dependent transcription, which decreased the transcriptional levels of downstream genes Early growth response protein 1 (EGR1)-Polycomb ring finger (BMI1), thus inducing the imbalanced regulation between Myeloid cell leukaemia-1 (MCL1) and F-Box and WD repeat domain containing 7 (FBXW7).	Folic Acid	50-53	F-box and WD repeat domain containing 7	Homo sapiens	479-484
33979572-6	2021	We showed, for the first time, that the cytotoxic effects of PGA occurred by inducing MCL1 inhibition and FBXW7 activation by blocking ELK1-SRF complex-dependent transcription.	Folic Acid	61-64	F-box and WD repeat domain containing 7	Homo sapiens	106-111
33967612-3	2021	To improve the therapeutic effects and reduce the side effects of NPC chemoradiotherapy, we constructed a multifunctional folic acid (FA)-targeted magnetic nanocomposite codelivering tissue factor pathway inhibitor-2 (TFPI-2) and cisplatin (CDDP).	Folic Acid	122-132	tissue factor pathway inhibitor 2	Homo sapiens	183-216
33884386-5	2021	In tumor bearing mice, co-injection with MiNP in a single multi-nanoparticle formulation significantly increased the accumulation of folate-receptor targeted nanoparticles within tumors.	Folic Acid	133-139	bMERB domain containing 1	Mus musculus	41-45
33926518-9	2021	Although erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) had a weak correlation with PGA, they were not statistically correlated with GS, PD, or GSPD.	Folic Acid	103-106	C-reactive protein	Homo sapiens	50-68
33926518-9	2021	Although erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) had a weak correlation with PGA, they were not statistically correlated with GS, PD, or GSPD.	Folic Acid	103-106	C-reactive protein	Homo sapiens	70-73
33919513-8	2021	B12 as well as to understand associations between plasma folate, vit.	Folic Acid	57-63	vitrin	Homo sapiens	65-68
33967612-3	2021	To improve the therapeutic effects and reduce the side effects of NPC chemoradiotherapy, we constructed a multifunctional folic acid (FA)-targeted magnetic nanocomposite codelivering tissue factor pathway inhibitor-2 (TFPI-2) and cisplatin (CDDP).	Folic Acid	122-132	tissue factor pathway inhibitor 2	Homo sapiens	218-224
33497860-10	2021	Folic acid down-regulated the expression levels of HO-1 and CHOP proteins through the two pathways of NrF2/HO-1 and GRP78/CHOP, thereby exerting a certain protective effect and alleviating the spleen caused by lead-induced oxidative stress and endoplasmic reticulum stress damage.	Folic Acid	0-10	NFE2 like bZIP transcription factor 2	Rattus norvegicus	102-106
33465566-7	2021	We found a 2- and 4-fold upregulation of miR-150-5p and miR-495-5p, respectively, in both the UUO and the folic acid induced nephropathy (FAN) models, while TGF-beta1 upregulated their expressions in the human renal tubular epithelial cell line HKC-8.	Folic Acid	106-116	microRNA 495	Homo sapiens	56-63
33662027-0	2021	Differential responses to folic acid in an established keloid fibroblast cell line are mediated by JAK1/2 and STAT3.	Folic Acid	26-36	Janus kinase 1	Homo sapiens	99-105
33662027-0	2021	Differential responses to folic acid in an established keloid fibroblast cell line are mediated by JAK1/2 and STAT3.	Folic Acid	26-36	signal transducer and activator of transcription 3	Homo sapiens	110-115
33662027-5	2021	In healthy volunteer fibroblasts, folic acid exposure recapitulated the exaggerated closure and hyper-glycolytic state of keloid fibroblasts through JAK1/2- and STAT3-dependent pathways.	Folic Acid	34-44	Janus kinase 1	Homo sapiens	149-155
33662027-5	2021	In healthy volunteer fibroblasts, folic acid exposure recapitulated the exaggerated closure and hyper-glycolytic state of keloid fibroblasts through JAK1/2- and STAT3-dependent pathways.	Folic Acid	34-44	signal transducer and activator of transcription 3	Homo sapiens	161-166
33875081-0	2021	Interferon Regulatory Factor 5 siRNA-Loaded Folate-Modified Cationic Liposomes for Acute Lung Injury Therapy.	Folic Acid	44-50	interferon regulatory factor 5	Mus musculus	0-30
33388720-4	2021	A g-CNQDs-based nanocarrier (g-CPF) is first prepared by successively introducing carboxyamino-terminated oligomeric polyethylene glycol and folic acid onto the surface of g-CNQDs via two-step amidation.	Folic Acid	141-151	nuclear receptor subfamily 5 group A member 2	Homo sapiens	31-34
32588217-0	2021	Unmetabolized folic acid is associated with TNF-alpha, IL-1beta and IL-12 concentrations in a population exposed to mandatory food fortification with folic acid: a cross-sectional population-based study in Sao Paulo, Brazil.	Folic Acid	14-24	tumor necrosis factor	Homo sapiens	44-53
33508345-0	2021	Design of folic acid decorated virus-mimicking nanoparticles for enhanced oral insulin delivery.	Folic Acid	10-20	insulin	Homo sapiens	79-86
33508345-10	2021	In conclusion, folic acid decorated virus-mimicking nanoparticles presented improved insulin absorption, implying combining mucus penetration and active transcellular transport is an effective way to promote oral insulin absorption, while the modification ratio of active ligand needs optimization.	Folic Acid	15-25	insulin	Homo sapiens	85-92
33508345-10	2021	In conclusion, folic acid decorated virus-mimicking nanoparticles presented improved insulin absorption, implying combining mucus penetration and active transcellular transport is an effective way to promote oral insulin absorption, while the modification ratio of active ligand needs optimization.	Folic Acid	15-25	insulin	Homo sapiens	213-220
32492698-8	2021	IMPACT: SAM synthesis pathway genetic variants are factors associated to NSCL/P.This article adds new evidence for folate related genes in NSCL/P in Chile.Its impact is to contribute with potential new markers for genetic counseling.	Folic Acid	115-121	nescient helix-loop-helix 1	Homo sapiens	73-77
32492698-8	2021	IMPACT: SAM synthesis pathway genetic variants are factors associated to NSCL/P.This article adds new evidence for folate related genes in NSCL/P in Chile.Its impact is to contribute with potential new markers for genetic counseling.	Folic Acid	115-121	nescient helix-loop-helix 1	Homo sapiens	139-143
33596128-0	2021	Folic acid ameliorates palmitate-induced inflammation through decreasing homocysteine and inhibiting NF-kappaB pathway in HepG2 cells.	Folic Acid	0-10	nuclear factor kappa B subunit 1	Homo sapiens	101-110
33302149-4	2021	Increased cell uptake of CTL-PEG-FA/Bcl-2 siRNA was achieved by the synergism of folate mediated endocytosis and charge interaction, and further causing severe HepG2 cells injury through apoptosis mechanism after down-regulation of Bcl-2 protein.	Folic Acid	81-87	BCL2 apoptosis regulator	Homo sapiens	36-41
33673278-3	2021	Here we report that transcripts for all bar two genes (i.e., BHMT, MAT1A) encoding enzymes in the linked methionine-folate cycles are expressed in all cell types within the ovarian follicle, oocyte, and blastocyst in the cow, sheep, and pig; as well as in rat granulosa cells (GCs) and human KGN cells (a granulosa-like tumor cell line).	Folic Acid	116-122	methionine adenosyltransferase 1A	Bos taurus	67-72
33540826-7	2021	SIGNIFICANCE STATEMENT We report that PGA acts as a TLR4 antagonist and this may be the basis of its potent anti-inflammatory activity.	Folic Acid	38-41	toll-like receptor 4	Mus musculus	52-56
33540826-8	2021	Being unique because of its potency and stability, as compared to other similar congeners, PGA can represent a tool for the optimization of new TLR4 modulating drugs directed against the cytokine storm and the chronization of inflammation.	Folic Acid	91-94	toll-like receptor 4	Mus musculus	144-148
33203700-5	2021	Delivery of a folate-targeted TLR7 agonist to these cells i) reduced their immunosuppressive function, ii) increased CD8+ T cell infiltration, iii) enhanced M1/M2 macrophage ratios, iv) inhibited tumor growth, v) blocked tumor metastasis, and vi) improved overall survival without demonstrable toxicity.	Folic Acid	14-20	toll like receptor 7	Homo sapiens	30-34
33183413-4	2021	Therefore, in this paper, folic acid-modified mesoporous silica nanoparticles (MSN-NH2-PEG-FA) were synthesized by modifying the folic acid on the surface of a drug carrier by using the characteristics of the expression of folic acid receptors, and using it as a drug.	Folic Acid	26-36	moesin	Homo sapiens	79-82
33220403-0	2021	High folic acid intake increases methylation-dependent expression of Lsr and dysregulates hepatic cholesterol homeostasis.	Folic Acid	5-15	lipolysis stimulated lipoprotein receptor	Mus musculus	69-72
33220403-2	2021	We previously showed that high folic acid intake was associated with hepatic degeneration, decreased levels of methylenetetrahydrofolate reductase (MTHFR), lower methylation potential, and perturbations of lipid metabolism.	Folic Acid	31-41	methylenetetrahydrofolate reductase	Mus musculus	111-146
33220403-2	2021	We previously showed that high folic acid intake was associated with hepatic degeneration, decreased levels of methylenetetrahydrofolate reductase (MTHFR), lower methylation potential, and perturbations of lipid metabolism.	Folic Acid	31-41	methylenetetrahydrofolate reductase	Mus musculus	148-153
33183413-4	2021	Therefore, in this paper, folic acid-modified mesoporous silica nanoparticles (MSN-NH2-PEG-FA) were synthesized by modifying the folic acid on the surface of a drug carrier by using the characteristics of the expression of folic acid receptors, and using it as a drug.	Folic Acid	129-139	moesin	Homo sapiens	79-82
33220403-3	2021	MTHFR synthesizes the folate derivative for methylation reactions.	Folic Acid	22-28	methylenetetrahydrofolate reductase	Mus musculus	0-5
33220403-4	2021	In this study, we assessed the possibility that high folic acid diets, fed to wild-type and Mthfr+/- mice, could alter DNA methylation and/or deregulate hepatic cholesterol homeostasis.	Folic Acid	53-63	methylenetetrahydrofolate reductase	Mus musculus	92-97
33183413-4	2021	Therefore, in this paper, folic acid-modified mesoporous silica nanoparticles (MSN-NH2-PEG-FA) were synthesized by modifying the folic acid on the surface of a drug carrier by using the characteristics of the expression of folic acid receptors, and using it as a drug.	Folic Acid	129-139	moesin	Homo sapiens	79-82
33220403-10	2021	Expression of genes in cholesterol synthesis, transport or turnover (Abcg5, Abcg8, Abcc2, Cyp46a1, Hmgcs1) was perturbed by high folic acid intake.	Folic Acid	129-139	ATP binding cassette subfamily G member 5	Mus musculus	69-74
33360378-4	2021	In addition to microbial lumazine metabolites, recent studies have demonstrated that MR1 is able to capture a variety of diverse chemical entities including folate-derivatives, a number of drug-like and other synthetic small molecules, and as yet undefined compounds of self-origin.	Folic Acid	157-163	major histocompatibility complex, class I-related	Homo sapiens	85-88
33220403-10	2021	Expression of genes in cholesterol synthesis, transport or turnover (Abcg5, Abcg8, Abcc2, Cyp46a1, Hmgcs1) was perturbed by high folic acid intake.	Folic Acid	129-139	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	Mus musculus	83-88
33152447-9	2021	Notably, CB2 potentiated Wnt1-induced beta-arrestin 1/beta-catenin activation and augmented the pathogenesis of kidney fibrosis in mice with unilateral ischemia-reperfusion injury or folic acid-induced nephropathy.. Knockdown of beta-arrestin 1 inhibited the CB2 agonist AM1241-induced beta-catenin activation and kidney fibrosis.	Folic Acid	183-193	cannabinoid receptor 2 (macrophage)	Mus musculus	9-12
33498619-0	2021	The Use of Lower or Higher Than Recommended Doses of Folic Acid Supplements during Pregnancy Is Associated with Child Attentional Dysfunction at 4-5 Years of Age in the INMA Project.	Folic Acid	53-63	renin binding protein	Homo sapiens	158-161
33498674-7	2021	The relative folate deficiency, as a result of an increased metabolic need for folate in obese women, can be due to: (1) low-grade chronic inflammation (2) insulin resistance, (3) inositol, and (4) dysbiotic gut microbiome, which plays a role in folate production and uptake.	Folic Acid	13-19	insulin	Homo sapiens	156-163
33498674-7	2021	The relative folate deficiency, as a result of an increased metabolic need for folate in obese women, can be due to: (1) low-grade chronic inflammation (2) insulin resistance, (3) inositol, and (4) dysbiotic gut microbiome, which plays a role in folate production and uptake.	Folic Acid	79-85	insulin	Homo sapiens	156-163
33498674-7	2021	The relative folate deficiency, as a result of an increased metabolic need for folate in obese women, can be due to: (1) low-grade chronic inflammation (2) insulin resistance, (3) inositol, and (4) dysbiotic gut microbiome, which plays a role in folate production and uptake.	Folic Acid	79-85	insulin	Homo sapiens	156-163
33181482-9	2021	Combing with DEG, 14 couples of lncRNAs and their target genes were both DE, and 6 of them including CCDC39, KCNJ16, NECTIN2, MRPL20, PSMC4, and DEFB112 show their potential infertility-related terms such as cellular motility, sperm maturation, sperm storage, cellular junction, folate metabolism, and capacitation.	Folic Acid	279-285	potassium inwardly rectifying channel subfamily J member 16	Bos taurus	109-115
33552089-5	2020	Methods: PD-L1 was analyzed in experimental mouse models of ischemia-reperfusion injury (IRI), folic acid-induced nephropathy (FAN), unilateral ureteral obstruction (UUO), and nephrotoxic serum nephritis (NTN) by immunostaining, SDS-PAGE, and subsequent immunoblotting.	Folic Acid	95-105	CD274 antigen	Mus musculus	9-14
33181482-9	2021	Combing with DEG, 14 couples of lncRNAs and their target genes were both DE, and 6 of them including CCDC39, KCNJ16, NECTIN2, MRPL20, PSMC4, and DEFB112 show their potential infertility-related terms such as cellular motility, sperm maturation, sperm storage, cellular junction, folate metabolism, and capacitation.	Folic Acid	279-285	proteasome 26S subunit, ATPase 4	Bos taurus	134-139
33432521-2	2022	In this study, folate-targeted polymeric micellar carrier was successfully constructed to co-delivery of doxorubicin (DOX) and SIS3 (FA/DOX/SIS3 micelles), a specific Smad3 inhibitor which sensitizes ABCB1- and ABCG2-overexpressing cancer cells to chemotherapeutic agents.	Folic Acid	15-21	ATP binding cassette subfamily B member 1	Homo sapiens	200-205
33432521-2	2022	In this study, folate-targeted polymeric micellar carrier was successfully constructed to co-delivery of doxorubicin (DOX) and SIS3 (FA/DOX/SIS3 micelles), a specific Smad3 inhibitor which sensitizes ABCB1- and ABCG2-overexpressing cancer cells to chemotherapeutic agents.	Folic Acid	15-21	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	211-216
33497043-0	2021	A Association of MTHFR C677T and MTRR A66G Gene Polymorphisms with Iranian Male Infertility and Its Effect on Seminal Folate and Vitamin B12.	Folic Acid	118-124	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	33-37
33035662-0	2021	Oral absorption enhancement of the amyloid-beta oligomer eliminating compound RD2 by conjugation with folic acid.	Folic Acid	102-112	peripherin 2	Mus musculus	78-81
33035662-3	2021	To further enhance the oral absorption of RD2, folic acid has been conjugated to the d-peptide promoting an endocytosis-mediated uptake via a folate receptor located in the intestine.	Folic Acid	47-57	peripherin 2	Mus musculus	42-45
33035662-4	2021	Two different conjugation strategies were selected to obtain prodrugs with folic acid being cleaved after intestinal absorption releasing unmodified RD2 in order to enable RD2"s unaltered systemic efficacy.	Folic Acid	75-85	peripherin 2	Mus musculus	172-175
33505124-1	2021	Methionine synthase reductase (MTRR) is an important enzyme of the folate/homocysteine pathway.	Folic Acid	67-73	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	0-29
33505124-1	2021	Methionine synthase reductase (MTRR) is an important enzyme of the folate/homocysteine pathway.	Folic Acid	67-73	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	31-35
33443337-10	2021	Males had a significantly higher odds ratio (OR) of having folate levels below 12.2 nmol/L: OR 1.84 (95% confidence interval [95%CI] 1.66-2.05) in a non-adjusted model, and OR 2.02 (95%CI 1.82-2.27) adjusted for age, smoking status, body mass index, kidney function, albumin, and triglycerides levels.	Folic Acid	59-65	albumin	Homo sapiens	267-274
33411826-8	2021	Further, methyl-CpG binding protein 2 expression was significantly decreased with excess folic acid treatment with and without proper MTHFR expression.	Folic Acid	89-99	methyl-CpG binding protein 2	Homo sapiens	9-37
33411826-11	2021	Excess folic acid alone induced a decrease in TET3 expression.	Folic Acid	7-17	tet methylcytosine dioxygenase 3	Homo sapiens	46-50
33146801-1	2020	A miniaturized and integrated bioassay was developed based on molybdenum disulfide (MoS2) field-effect transistor (FET) functionalized with bovine serum albumin-folic acid (BSA-FA) for monitoring FOLR1.	Folic Acid	161-171	albumin	Homo sapiens	147-160
33091596-0	2021	Folic acid promotes proliferation and differentiation of porcine pancreatic stem cells into insulin-secreting cells through canonical Wnt and ERK signaling pathway.	Folic Acid	0-10	insulin	Homo sapiens	92-99
33091596-0	2021	Folic acid promotes proliferation and differentiation of porcine pancreatic stem cells into insulin-secreting cells through canonical Wnt and ERK signaling pathway.	Folic Acid	0-10	mitogen-activated protein kinase 1	Homo sapiens	142-145
33091596-3	2021	In this study, we explored the role of folic acid in the proliferation of pPSCs and the formation of insulin-secreting cells.	Folic Acid	39-49	insulin	Homo sapiens	101-108
32826232-3	2020	We establish that folate restriction and deficiency of the rate-limiting folate cycle enzyme, MTHFR - which exhibits reduced-function polymorphisms in about 10% of Caucasians - induce resistance to MYC targeting by BET and CDK7 inhibitors in cell lines, primary patient samples, and syngeneic mouse models of AML.	Folic Acid	18-24	cyclin dependent kinase 7	Homo sapiens	223-227
32826232-3	2020	We establish that folate restriction and deficiency of the rate-limiting folate cycle enzyme, MTHFR - which exhibits reduced-function polymorphisms in about 10% of Caucasians - induce resistance to MYC targeting by BET and CDK7 inhibitors in cell lines, primary patient samples, and syngeneic mouse models of AML.	Folic Acid	73-79	cyclin dependent kinase 7	Homo sapiens	223-227
32919690-0	2020	Folic acid-modified bovine serum albumin nanoparticles with doxorubicin and chlorin e6 for effective combinational chemo-photodynamic therapy.	Folic Acid	0-10	albumin	Homo sapiens	27-40
32919690-1	2020	We herein describe a facile method to synthesize stable bovine serum albumin-based nanoparticles (BNPs) loaded with two anticancer therapeutics, doxorubicin (DOX) and a photosensitizer, chlorin e6 (Ce6), in combination with folic acid (FA) as a target cancer cell receptor for the development of an effective combined chemo and photodynamic (FA-Ce6/DOX/BNPs) therapy against cervical cancer.	Folic Acid	224-234	albumin	Homo sapiens	63-76
32789462-9	2020	Construct validity was demonstrated by a good correlation (r >= 0.50) between the PGA with the SLEDAI (12 studies), SLAM (4 studies), LAI, BILAG and ECLAM (2 studies each).	Folic Acid	82-85	signaling lymphocytic activation molecule family member 1	Homo sapiens	116-120
33257796-4	2020	Despite the high binding percentage of 5-aminosalicylates for human serum albumin (> 61.44%), results have shown that folic acid binding to human serum albumin protein is far greater (69.40%) compared to alpha1-acid-glycoprotein (3.45%).	Folic Acid	118-128	albumin	Homo sapiens	146-159
33257796-5	2020	Frontal analysis and zonal elution studies were conducted to provide an insight into the binding of folic acid to human serum albumin and potential competition with 5-aminosalicylates.	Folic Acid	100-110	albumin	Homo sapiens	120-133
32912792-9	2020	More importantly, the relationship between LDL-C and CIMT was significantly attenuated with increasing serum folate levels (1st tertile: beta = 10.06, 95%CI: 6.67-13.46; 2nd tertile: beta = 6.81, 95%CI: 3.55-10.07; 3rd tertile: beta = 5.96, 95%CI: 2.55-9.36; P-interaction = 0.045).	Folic Acid	109-115	component of oligomeric golgi complex 2	Homo sapiens	43-48
32912792-10	2020	Subgroup analyses showed the association between LDL-C and CIMT across serum folate tertiles was robust among various strata (all P-interaction >0.05).	Folic Acid	77-83	component of oligomeric golgi complex 2	Homo sapiens	49-54
32912792-11	2020	CONCLUSIONS: Among Chinese hypertensive adults, the serum folate levels could modify the association between LDL-C and CIMT.	Folic Acid	58-64	component of oligomeric golgi complex 2	Homo sapiens	109-114
32975579-6	2020	This increase of SQOR induces the downregulation of the cystathionine beta-synthase and cystathionine gamma-lyase, two enzymes of the transsulfuration pathway, the subsequent downregulation of serine biosynthesis and the adaptation of other sulfide linked pathways, such as folate cycle, nucleotides metabolism and glutathione system.	Folic Acid	274-280	cystathionine beta-synthase	Homo sapiens	56-83
33525287-9	2020	Moreover, there was a significant inverse correlation between serum folate levels and C-reactive protein in IBD patients (r = -0.563 p =0.001).	Folic Acid	68-74	C-reactive protein	Homo sapiens	86-104
33172086-7	2020	In addition, folate and creatinine were elevated in the EVs from prostate and CTCL cancer cell lines.	Folic Acid	13-19	TSPY like 2	Homo sapiens	78-82
33749643-12	2021	CONCLUSION: Folic acid and DHA improve cognitive function and reduce blood Abeta production in MCI patients.	Folic Acid	12-22	amyloid beta precursor protein	Homo sapiens	75-80
33160997-10	2021	Senescence-associated beta-galactosidase activity staining revealed that folic acid attenuated cardiac senescence by down-regulating p53/p21/p16 levels.	Folic Acid	73-83	cyclin dependent kinase inhibitor 2A	Mus musculus	141-144
32985928-0	2021	Co-administration of Paclitaxel and 2-Methoxyestradiol using folate-conjugated human serum albumin nanoparticles for improving drug resistance and antitumor efficacy.	Folic Acid	61-67	albumin	Homo sapiens	85-98
32985928-2	2021	This research aims to co-encapsulate Paclitaxel (PTX) and the chemosensitizer 2-Methoxyestradiol (2-ME) into folate-conjugated human serum albumin nanoparticles (FA-HSANPs) to reduce multiple drug resistance and improve anti-tumor efficiency.	Folic Acid	109-115	albumin	Homo sapiens	133-146
33372619-0	2020	MicroRNA-302a is involved in folate deficiency-induced apoptosis through the AKT-FOXO1-BIM pathway in mouse embryonic stem cells.	Folic Acid	29-35	microRNA 302a	Mus musculus	0-13
33372619-0	2020	MicroRNA-302a is involved in folate deficiency-induced apoptosis through the AKT-FOXO1-BIM pathway in mouse embryonic stem cells.	Folic Acid	29-35	thymoma viral proto-oncogene 1	Mus musculus	77-80
33372619-1	2020	BACKGROUND: Our previous study had shown that microRNA (miR)-302a played a key role in folate deficiency-induced apoptosis in mouse embryonic stem cells.	Folic Acid	87-93	microRNA 302a	Mus musculus	46-65
33372619-11	2020	Real-time quantitative PCR and immunoblotting showed that in folate-free conditions, miR-302a and AKT were down regulated, while FOXO1 and Bim were up-regulated significantly.	Folic Acid	61-67	microRNA 302a	Mus musculus	85-93
33372619-11	2020	Real-time quantitative PCR and immunoblotting showed that in folate-free conditions, miR-302a and AKT were down regulated, while FOXO1 and Bim were up-regulated significantly.	Folic Acid	61-67	thymoma viral proto-oncogene 1	Mus musculus	98-101
33372619-12	2020	Additionally, treatment with LY294002 inhibitor revealed the involvement of the Akt/FOXO1/Bim signaling pathway in folate deficiency-induced apoptosis, rather than the ERK pathway.	Folic Acid	115-121	thymoma viral proto-oncogene 1	Mus musculus	80-83
33372619-14	2020	CONCLUSION: The involvement of miR-302a in folate deficiency-induced apoptosis through the AKT-FOXO1-BIM pathway in mESCs is a unique demonstration of the regulation mechanism of nutrient expression in embryonic development.	Folic Acid	43-49	microRNA 302a	Mus musculus	31-39
33372619-14	2020	CONCLUSION: The involvement of miR-302a in folate deficiency-induced apoptosis through the AKT-FOXO1-BIM pathway in mESCs is a unique demonstration of the regulation mechanism of nutrient expression in embryonic development.	Folic Acid	43-49	thymoma viral proto-oncogene 1	Mus musculus	91-94
33164984-3	2020	The folate pathway genes SLC19A1, ABCC1, ABCC4, FPGS, and MTHFD1 significantly influenced intracellular MTXPG levels (P = 2.9 x 10-3 to 3.7 x 10-8).	Folic Acid	4-10	ATP binding cassette subfamily C member 1	Homo sapiens	34-39
33164984-3	2020	The folate pathway genes SLC19A1, ABCC1, ABCC4, FPGS, and MTHFD1 significantly influenced intracellular MTXPG levels (P = 2.9 x 10-3 to 3.7 x 10-8).	Folic Acid	4-10	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	58-64
32413886-3	2020	In this study, an MSN-based drug carrier system was synthesized with biocompatible gold nanoparticles as the "hard caps", and folic acid conjugated to the surface for targeting folate receptor (FR)-overexpressed cancer cells.	Folic Acid	126-136	moesin	Homo sapiens	18-21
33092534-7	2020	We found population-specific as well as shared signals of selection, with folate metabolism and the related ultraviolet response and skin pigmentation standing out as a shared pathway, perhaps as a response to the high levels of ultraviolet irradiation, and in addition strong signals in genes such as IFNA, MRC1, immunoglobulins and T-cell receptors which contribute to defend against pathogens.	Folic Acid	74-80	IFN1@	Homo sapiens	302-306
33121283-1	2020	Objective: Although genetic variants of key enzymes in the folic acid-methionine metabolic circulation, including methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) were thought to be related to the risk of recurrent pregnancy loss (RPL), the results of recent studies have been inconsistent.	Folic Acid	59-69	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	193-197
33049960-9	2020	Finally, PGA-cur significantly counteracted MIA-induced increase in serum levels of TNF-alpha, IL-1beta, NGF, as well as metalloproteases 1, 3, and 9.	Folic Acid	9-12	tumor necrosis factor	Rattus norvegicus	84-93
33093609-5	2020	Pathway enrichment analysis revealed that drug metabolism-cytochrome P450, biopterin metabolism, vitamin B9 (folate) metabolism, selenoamino acid metabolism, and methionine and cysteine metabolism showed significant enrichment in vitiligo patients compared with the status in healthy controls.	Folic Acid	109-115	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	58-73
33037506-10	2020	The bio-imaging of ex vivo tissues demonstrated that the DiR loaded folate targeted LPNs exhibited intense signals after 24 h because of slow release of DiR dye from the nanoparticles.	Folic Acid	68-74	arginine vasopressin receptor 2	Homo sapiens	57-60
33037506-10	2020	The bio-imaging of ex vivo tissues demonstrated that the DiR loaded folate targeted LPNs exhibited intense signals after 24 h because of slow release of DiR dye from the nanoparticles.	Folic Acid	68-74	arginine vasopressin receptor 2	Homo sapiens	153-156
33037575-0	2021	Folic Acid Deficiency Enhances the Tyr705 and Ser727 Phosphorylation of Mitochondrial STAT3 in In Vivo and In Vitro Models of Ischemic Stroke.	Folic Acid	0-10	signal transducer and activator of transcription 3	Homo sapiens	86-91
33049960-9	2020	Finally, PGA-cur significantly counteracted MIA-induced increase in serum levels of TNF-alpha, IL-1beta, NGF, as well as metalloproteases 1, 3, and 9.	Folic Acid	9-12	interleukin 1 alpha	Rattus norvegicus	95-103
33050248-4	2020	Folic acid (0, 2.0, 5.0, 12.5 ppm) increased linearly (P < 0.05) serum K, Ca, P, Mg, and AST with the largest effect observed at 12.5 ppm.	Folic Acid	0-10	AST	Sus scrofa	89-92
33179601-5	2020	The re-methylation reaction not only involves the enzymes methionine synthase and methionine synthase reductase but also depends on the cofactor cobalamin and on the provision of methyl groups from the folate cycle.	Folic Acid	202-208	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	82-111
33102939-0	2021	Folic acid-modified Exosome-PH20 enhances the efficiency of therapy via modulation of the tumor microenvironment and directly inhibits tumor cell metastasis.	Folic Acid	0-10	sperm adhesion molecule 1	Homo sapiens	28-32
33026590-9	2021	In a multiple logistic regression model, increased CRP levels were significantly associated with deficiencies of vitamin B12 (OR = 5.84; 95% CI 1.25-27.2; p = 0.024), folate (OR = 4.02; 1.87-8.66; p < 0.001), and with the presence of >= 2 micronutrient deficiencies (OR = 2.31; 1.21-4.42; p = 0.01).	Folic Acid	167-173	C-reactive protein	Homo sapiens	51-54
32585538-0	2020	Folate targeted PEGylated liposomes for the oral delivery of insulin: In vitro and in vivo studies.	Folic Acid	0-6	insulin	Homo sapiens	61-68
32526472-7	2020	FOLR3 exerts anti-microbial and anti-tumor effects by depriving bacteria and tumor cells of natural folates.	Folic Acid	100-107	folate receptor gamma	Homo sapiens	0-5
32269290-11	2020	Further missense or frameshift mutations were observed in the KRAS, APC, TP53, and CTNNB1 genes in the PGA group.	Folic Acid	103-106	tumor protein p53	Homo sapiens	73-77
32759013-4	2020	Our work has shown that, in the systemic circulation, folic acid in high dose rapidly improves nitric oxide mediated vasodilation, by activating endothelial nitric oxide synthase (eNOS).	Folic Acid	54-64	nitric oxide synthase 3	Homo sapiens	145-178
32759013-4	2020	Our work has shown that, in the systemic circulation, folic acid in high dose rapidly improves nitric oxide mediated vasodilation, by activating endothelial nitric oxide synthase (eNOS).	Folic Acid	54-64	nitric oxide synthase 3	Homo sapiens	180-184
32737139-9	2020	Higher folate intake was also associated with lower plasma homocysteine (P trend < 0.01) and insulin (P trend < 0.01).	Folic Acid	7-13	insulin	Homo sapiens	93-100
32737139-10	2020	Among supplement users, folate intake was inversely associated with serum C-reactive protein levels (P trend < 0.01).	Folic Acid	24-30	C-reactive protein	Homo sapiens	74-92
32967380-5	2020	Importantly, FOL-MSN-BTZ treated FR- normal cells did not show any significant sign of injury or metabolic perturbation, while free BTZ was still highly toxic.	Folic Acid	13-16	moesin	Homo sapiens	17-20
32605885-7	2020	Analysis of the relationship between ABCG1-mediated CEC and glycemia, homocysteine, total folates and interleukin-6 showed specific changes in the correlations between HDL function and glycemia, oxidative and inflammatory markers only after synbiotic pasta consumption.	Folic Acid	90-97	ATP binding cassette subfamily G member 1	Homo sapiens	37-42
32967380-7	2020	These data show the striking specificity of FOL-MSN-BTZ toward FR+ tumor cells and the outstanding safety of the MSN-FOL vehicle, paving the way for a future exploitation of FOL-MSN-BTZ in MM target therapy.	Folic Acid	44-47	moesin	Homo sapiens	48-51
32803503-8	2020	Folate and B12 deficiencies were observed in CAD cases, which were shown to contribute to hypomethylation and upregulation of the prime candidate genes i.e. CDKN2A and F2RL3.	Folic Acid	0-6	cyclin dependent kinase inhibitor 2A	Homo sapiens	157-163
32929075-0	2020	MT1DP loaded by folate-modified liposomes sensitizes erastin-induced ferroptosis via regulating miR-365a-3p/NRF2 axis in non-small cell lung cancer cells.	Folic Acid	16-22	NFE2 like bZIP transcription factor 2	Homo sapiens	108-112
33066869-1	2020	OBJECTIVE: This study was conducted to investigate and compare the effects of add-on folic acid and vitamin B12 supplementation on glycaemic control, insulin resistance and serum lipid profile in subjects with type 2 diabetes mellitus.	Folic Acid	85-95	insulin	Homo sapiens	150-157
32993976-3	2020	Folic acid was conjugated to bovine serum albumin by amide bond at a binding rate of 9.46 +- 0.49 folate molecules per bovine serum albumin.	Folic Acid	0-10	albumin	Homo sapiens	36-49
32993976-3	2020	Folic acid was conjugated to bovine serum albumin by amide bond at a binding rate of 9.46 +- 0.49 folate molecules per bovine serum albumin.	Folic Acid	0-10	albumin	Homo sapiens	126-139
32993976-3	2020	Folic acid was conjugated to bovine serum albumin by amide bond at a binding rate of 9.46 +- 0.49 folate molecules per bovine serum albumin.	Folic Acid	98-104	albumin	Homo sapiens	36-49
32993976-3	2020	Folic acid was conjugated to bovine serum albumin by amide bond at a binding rate of 9.46 +- 0.49 folate molecules per bovine serum albumin.	Folic Acid	98-104	albumin	Homo sapiens	126-139
31628923-6	2020	CONCLUSION: EPO therapy in conjunction with iron, vitamin E and folic acid, stimulated erythropoiesis and significantly reduced the need for blood transfusion in AOP.	Folic Acid	64-74	erythropoietin	Homo sapiens	12-15
32597014-4	2020	Based on the expression of folate receptor beta solely on activated myeloid cells, we have created a folate-targeted TLR7 agonist (FA-TLR7-54) that selectively accumulates in profibrotic macrophages and suppresses fibrosis-inducing cytokine production.	Folic Acid	27-33	toll like receptor 7	Homo sapiens	117-121
32842348-11	2020	In the multivariate analysis, smoking, vitamin B12 and folic acid in the RAU group were significantly correlated with the overall methylation rate of the IL-4 gene promoter (P<0.01).	Folic Acid	55-65	interleukin 4	Homo sapiens	154-158
32842348-13	2020	Vitamin B12, folic acid and smoking may affect IL-4 gene methylation in peripheral blood of RAU patients.	Folic Acid	13-23	interleukin 4	Homo sapiens	47-51
32820034-2	2021	Mutations in several folate pathway genes, including FOLR1 (folate receptor alpha, FRalpha), DHFR (dihydrofolate reductase) and PCFT (proton coupled folate transporter) have been previously identified in patients with CFD.Methods In an effort to identify causal mutations for CFD, we performed whole exome sequencing analysis on eight CFD trios and identified eight de novo mutations in seven trios.Results Notably, we found a de novo stop gain mutation in the capicua (CIC) gene.	Folic Acid	21-27	capicua transcriptional repressor	Homo sapiens	461-468
32820034-2	2021	Mutations in several folate pathway genes, including FOLR1 (folate receptor alpha, FRalpha), DHFR (dihydrofolate reductase) and PCFT (proton coupled folate transporter) have been previously identified in patients with CFD.Methods In an effort to identify causal mutations for CFD, we performed whole exome sequencing analysis on eight CFD trios and identified eight de novo mutations in seven trios.Results Notably, we found a de novo stop gain mutation in the capicua (CIC) gene.	Folic Acid	21-27	capicua transcriptional repressor	Homo sapiens	470-473
32820034-4	2021	Functional analysis indicates that CIC binds to an octameric sequence in the promoter regions of folate transport genes: FOLR1, PCFT and reduced folate carrier (Slc19A1; RFC1).	Folic Acid	97-103	capicua transcriptional repressor	Homo sapiens	35-38
32820034-4	2021	Functional analysis indicates that CIC binds to an octameric sequence in the promoter regions of folate transport genes: FOLR1, PCFT and reduced folate carrier (Slc19A1; RFC1).	Folic Acid	145-151	capicua transcriptional repressor	Homo sapiens	35-38
32796716-6	2020	Its decreased expression plays a prominent role in the heart, liver and brain of rat as manifestations of fetal programming produced by deficit in vitamin B12 and folate during pregnancy and lactation through imbalanced methylation/acetylation of PGC1alpha and altered expression and methylation of nuclear receptors.	Folic Acid	163-169	PPARG coactivator 1 alpha	Rattus norvegicus	247-256
32546391-0	2020	Letter to the Editor: Comment on "Folate and vitamin B12 status is associated with insulin resistance and metabolic syndrome in morbid obesity".	Folic Acid	34-40	insulin	Homo sapiens	83-90
32756356-3	2020	MR1 senses the presence of intermediate metabolites of riboflavin and folic acid synthesis that have been chemically modified by the side-products of glycolysis, glyoxal or methylglyoxal.	Folic Acid	70-80	major histocompatibility complex, class I-related	Homo sapiens	0-3
32241696-8	2020	Further study showed that folate and vitamin B6 might decrease the risk of estrogen receptor-negative (ER-)/progesterone receptor-negative (PR-) breast cancer but not ER+/PR+ breast cancer.	Folic Acid	26-32	estrogen receptor 1	Homo sapiens	75-92
32163191-1	2020	To improve water solubility, reduce phototoxicity and increase the tumor-targeting ability of hematoporphyrin (Hp) as a sonosensitizer for sonodynamic therapy under ultrasonic conditions, a novel folate receptor (FR)-targeted, folate-conjugated ethylenediamine-beta-cyclodextrin (FA-EN-beta-CD) containing Hp (FA-EN-beta-CD-Hp) was constructed.	Folic Acid	196-202	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	286-293
32238907-8	2020	Four exonic CpG-SNPs of MTHFD1, MTRR, and GGH genes were identified in folate pathway genes.	Folic Acid	71-77	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	24-30
32543769-2	2020	Folate transport across biological membranes is mediated by three major pathways: folate receptor alpha (FRalpha), proton-coupled folate transporter (PCFT), and reduced folate carrier (RFC).	Folic Acid	0-6	rabaptin, RAB GTPase binding effector protein 2	Mus musculus	105-112
32543769-3	2020	Brain folate transport primarily occurs at the choroid plexus through FRalpha and PCFT; inactivation of these transport systems results in suboptimal folate levels in the cerebrospinal fluid (CSF) causing childhood neurological disorders.	Folic Acid	6-12	rabaptin, RAB GTPase binding effector protein 2	Mus musculus	70-77
32543769-10	2020	Together, these findings demonstrate that NRF-1/PGC-1alpha activation by PQQ upregulates RFC functional expression at the BBB and could potentially enhance brain folate uptake.	Folic Acid	162-168	nuclear respiratory factor 1	Mus musculus	42-47
32238907-8	2020	Four exonic CpG-SNPs of MTHFD1, MTRR, and GGH genes were identified in folate pathway genes.	Folic Acid	71-77	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	32-36
32722447-5	2020	The association between the serum folate level and lung function in patients with COPD was evaluated using multivariable linear regression analysis after adjustment for age, sex, height, high sensitivity C-reactive protein, total calorie intake, residence, smoking status and smoking pack-years, education, and household income.	Folic Acid	34-40	C-reactive protein	Homo sapiens	204-222
32765812-0	2020	Folic acid supplementation prevents high fructose-induced non-alcoholic fatty liver disease by activating the AMPK and LKB1 signaling pathways.	Folic Acid	0-10	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	110-114
32765812-6	2020	Moreover, folic acid supplementation in rats fed high fructose enhanced the levels of phosphorylated AMP-activated protein kinase (AMPK) and liver kinase B (LKB1) and inhibited phosphorylation of acetyl coenzyme A carboxylase (ACC) in the liver.	Folic Acid	10-20	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	101-129
32765812-6	2020	Moreover, folic acid supplementation in rats fed high fructose enhanced the levels of phosphorylated AMP-activated protein kinase (AMPK) and liver kinase B (LKB1) and inhibited phosphorylation of acetyl coenzyme A carboxylase (ACC) in the liver.	Folic Acid	10-20	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	131-135
32765812-7	2020	CONCLUSIONS: These results suggest that the protective effect of folic acid supplementation in rats fed high fructose may include the activation of LKB1/AMPK/ACC and increased SAM in the liver, which inhibit hepatic lipogenesis, thus ameliorating hepatic steatosis.	Folic Acid	65-75	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	153-157
32774701-3	2020	Folic acid was used to induce kidney injury C57BL/6 mouse model followed by analysis of serum creatinine, renal weight ratio changes, renal pathological changes and STAT3/mTOR pathway changes.	Folic Acid	0-10	signal transducer and activator of transcription 3	Mus musculus	165-170
32707539-0	2020	Targeting CD146 using folic acid-conjugated nanoparticles and suppression of tumor growth in a mouse glioma model.	Folic Acid	22-32	melanoma cell adhesion molecule	Mus musculus	10-15
32707539-4	2020	In this study, the authors aimed to develop gene therapy targeting GSCs using chitosan oligosaccharide lactate (COL) nanoparticles (NPs) conjugated with folic acid-polyethylene glycol (FA-PEG-COL NPs) for in vitro and in vivo delivery of CD146 small-interfering RNA (siCD146) and to determine the effect of CD146 knockdown on tumor growth.	Folic Acid	153-163	melanoma cell adhesion molecule	Mus musculus	238-243
32707539-4	2020	In this study, the authors aimed to develop gene therapy targeting GSCs using chitosan oligosaccharide lactate (COL) nanoparticles (NPs) conjugated with folic acid-polyethylene glycol (FA-PEG-COL NPs) for in vitro and in vivo delivery of CD146 small-interfering RNA (siCD146) and to determine the effect of CD146 knockdown on tumor growth.	Folic Acid	153-163	melanoma cell adhesion molecule	Mus musculus	269-274
32774701-7	2020	Folic acid-induced injury of mesangial cells showed inhibited cell proliferation, promoted apoptosis, increased LC3II expression, decreased p62 expression, increased autophagic vacuoles and expression of STAT3 and p-mTOR as well as decreased E-cadherin expression and increased Vimentin expression.	Folic Acid	0-10	signal transducer and activator of transcription 3	Mus musculus	204-209
32774701-7	2020	Folic acid-induced injury of mesangial cells showed inhibited cell proliferation, promoted apoptosis, increased LC3II expression, decreased p62 expression, increased autophagic vacuoles and expression of STAT3 and p-mTOR as well as decreased E-cadherin expression and increased Vimentin expression.	Folic Acid	0-10	cadherin 1	Mus musculus	242-252
33463352-7	2020	In summary, the results of this study revealed that US-MB-mediated codelivery of SIK2 siRNA, and anti-miR21 encapsulated in a folate-lipid-PLGA hybrid polymer nanoparticle could significantly improve the sensitivity of EOC tumors to PTX and is a highly effective approach for treating EOC in complementary experiments.	Folic Acid	126-132	salt inducible kinase 2	Homo sapiens	81-85
32635272-4	2020	The cellular uptake of PBC 1 and PBC 3 by HeLa cells was arrested by increasing the concentration of folate in the medium, indicating that the major uptake mechanisms of PBC 1-3 are primarily through FRalpha receptor-mediated endocytosis.	Folic Acid	101-107	PBC3	Homo sapiens	33-38
32571957-0	2020	Vitamin B12 and folic acid alleviate symptoms of nutritional deficiency by antagonizing aryl hydrocarbon receptor.	Folic Acid	16-26	aryl-hydrocarbon receptor	Mus musculus	88-113
32635272-4	2020	The cellular uptake of PBC 1 and PBC 3 by HeLa cells was arrested by increasing the concentration of folate in the medium, indicating that the major uptake mechanisms of PBC 1-3 are primarily through FRalpha receptor-mediated endocytosis.	Folic Acid	101-107	PBC2	Homo sapiens	170-177
32353563-1	2020	In eucaryotic cells, methionine synthase reductase (MSR/MTRR) is capable of dominating the folate-homocysteine metabolism as an irreplaceable partner in electron transfer for regeneration of methionine synthase.	Folic Acid	91-97	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	52-55
32353563-1	2020	In eucaryotic cells, methionine synthase reductase (MSR/MTRR) is capable of dominating the folate-homocysteine metabolism as an irreplaceable partner in electron transfer for regeneration of methionine synthase.	Folic Acid	91-97	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	56-60
32414565-2	2020	It is encoded by MTHFD1 and functions in the cytoplasmic folate cycle where it is involved in de novo purine synthesis, synthesis of thymidylate and remethylation of homocysteine to methionine.	Folic Acid	57-63	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	17-23
32203239-9	2020	RESULTS: MTHFD rs1950902 and MTRR rs162036, rs1801394 was associated with the folate treatment response (P = 0.000, 0.048, and 0.043, respectively).	Folic Acid	78-84	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	29-33
32203239-11	2020	DNA methylation of MTHFR, MTR, and MTRR was also significantly associated with folate treatment response (P < 0.001).	Folic Acid	79-85	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	35-39
32521649-11	2020	These results indicate that moderate folate supplementation downregulates MTHFR and alters choline/methyl metabolism, contributing to neurobehavioral alterations.	Folic Acid	37-43	methylenetetrahydrofolate reductase	Mus musculus	74-79
32581311-6	2020	The ectopic expression of FOLR3 enhanced cell growth, and the enhanced effect was neutralised by folic acid-deficient media.	Folic Acid	97-107	folate receptor gamma	Homo sapiens	26-31
32581311-8	2020	The folic acid intake of FOLR3+ cells was higher than that of wild-type cells.	Folic Acid	4-14	folate receptor gamma	Homo sapiens	25-30
32581311-11	2020	Our study emphasizes the role of FOLR3 in the intake of folic acid into cells on the one hand and its protective role in Hcy-induced cytotoxicity on the other.	Folic Acid	56-66	folate receptor gamma	Homo sapiens	33-38
32655788-7	2020	In vitro IHR stimuli in human monocytic THP-1 cells resulted in gene promoter hypomethylation-mediated FPR1 over-expression, increased production of reactive oxygen species, and increased cell apoptosis, which could be reversed with re-methylation agent, folic acid, treatment.	Folic Acid	255-265	GLI family zinc finger 2	Homo sapiens	40-45
32655788-7	2020	In vitro IHR stimuli in human monocytic THP-1 cells resulted in gene promoter hypomethylation-mediated FPR1 over-expression, increased production of reactive oxygen species, and increased cell apoptosis, which could be reversed with re-methylation agent, folic acid, treatment.	Folic Acid	255-265	formyl peptide receptor 1	Homo sapiens	103-107
30829139-8	2020	According to univariate analysis, at baseline folate showed a significantly positive correlation with high-density lipoprotein cholesterol (p = 0.028, rho = 0.204), apolipoprotein A-I (p = 0.006, rho = 0.268) and vitamin B12 (p = 0.040, rho = 0.192), and a significantly negative correlation with triglycerides (p = 0.049, rho = -0.184).	Folic Acid	46-52	apolipoprotein A1	Homo sapiens	165-183
32219330-1	2020	CONTEXT: Vitamin B12 and folate deficiency are not only linked to hematological, neurological and cardiovascular diseases, but also associate with insulin resistance.	Folic Acid	25-31	insulin	Homo sapiens	147-154
32469605-0	2020	Effect of folic acid and vitamin E on promoter DNA methylation and expression of TGF-beta1, ESR-1 and CDH-1 in the uterus of STZ-induced diabetic rats.	Folic Acid	10-20	transforming growth factor, beta 1	Rattus norvegicus	81-90
32145458-2	2020	Two intracellular enzymes, methionine synthase and methylmalonyl-CoA mutase, are folate and/or cobalamin-dependent, respectively.	Folic Acid	81-87	methylmalonyl-CoA mutase	Sus scrofa	51-75
32019627-6	2020	Folate catabolite apABG was positively correlated with IL-6 (r= 0.27, plinear&lt;0.0001) and pABG was positively correlated with IL-8 (r= 0.21, plinear&lt;0.0001), indicating higher folate utilization during inflammation.Our data support the hypothesis of inverse associations between PLP and inflammatory biomarkers among colorectal cancer patients.	Folic Acid	0-6	interleukin 6	Homo sapiens	55-59
32443475-0	2020	Independent and Interactive Influences of Environmental UVR, Vitamin D Levels, and Folate Variant MTHFD1-rs2236225 on Homocysteine Levels.	Folic Acid	83-89	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	98-104
32523342-3	2020	Purpose: The primary aim of this study is to develop biomimetic rLips by utilizing folic acid (FA)-modified bovine serum albumin (BSA) as a replacement for apolipoprotein and demonstrate its tumor targeting and antitumor efficacy.	Folic Acid	83-93	albumin	Homo sapiens	115-128
32483451-5	2020	In order to protect the cargo enzyme from digestion by protease and prolong blood circulating time, SOD-Fe0@Lapa-Z was further cloaked with RBC membrane and functionalized with folate targeting, resulting in the final advanced biomimetic nanoreactor SOD-Fe0@Lapa-ZRF.	Folic Acid	177-183	superoxide dismutase 1	Homo sapiens	100-107
32483451-5	2020	In order to protect the cargo enzyme from digestion by protease and prolong blood circulating time, SOD-Fe0@Lapa-Z was further cloaked with RBC membrane and functionalized with folate targeting, resulting in the final advanced biomimetic nanoreactor SOD-Fe0@Lapa-ZRF.	Folic Acid	177-183	superoxide dismutase 1	Homo sapiens	250-257
32476787-0	2020	Folic acid attenuates high-fat diet-induced steatohepatitis via deacetylase SIRT1-dependent restoration of PPARalpha.	Folic Acid	0-10	sirtuin 1	Rattus norvegicus	76-81
32476787-8	2020	Furthermore, peroxisome proliferator-activated receptor alpha (PPARalpha) and silence information regulation factor 1 (SIRT1) were restored by folic acid in HFD-fed rats and palmitic acid-exposed Huh7 cell line.	Folic Acid	143-153	sirtuin 1	Rattus norvegicus	119-124
32476787-11	2020	CONCLUSION: Folic acid improves hepatic lipid metabolism by upregulating PPARalpha levels via a SIRT1-dependent mechanism and restores hepatic one-carbon metabolism and diversity of gut microbiota, thereby attenuating HFD-induced NASH in rats.	Folic Acid	12-22	sirtuin 1	Rattus norvegicus	96-101
32384607-4	2020	We identified six genes (GART, PFAS, PPAT, PAICS, ATIC, and ADSL) whose blocking results in nearly the same effect in the metabolic network as folate depletion.	Folic Acid	143-149	phosphoribosylformylglycinamidine synthase	Homo sapiens	31-35
32476787-8	2020	Furthermore, peroxisome proliferator-activated receptor alpha (PPARalpha) and silence information regulation factor 1 (SIRT1) were restored by folic acid in HFD-fed rats and palmitic acid-exposed Huh7 cell line.	Folic Acid	143-153	sirtuin 1	Rattus norvegicus	78-117
31775133-0	2020	Design, insilico modelling and functionality theory of folate receptor targeted Myricetin -loaded bovine serum albumin nanoparticle formulation for cancer treatment.	Folic Acid	55-61	albumin	Homo sapiens	105-118
32266834-5	2020	Results: The study demonstrates that the genetic variants in folate cycle and methionine cycle genes such as MTHFR, MTRR, MTR, BHMT and DNMT1 are associated with the risk of aneurysm.	Folic Acid	61-67	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	116-120
31775133-3	2020	Here, a folic acid (FA) conjugated bovine serum albumin (BSA) nanoparticles (NPs) were used to encapsulate myricetin (Myr).	Folic Acid	8-18	albumin	Homo sapiens	42-55
31984590-1	2020	Folate receptors (FRs) are membrane proteins involved in folic acid uptake, and the alpha isoform (FR-a) is overexpressed in ovarian and endometrial cancer cells.	Folic Acid	0-6	rabaptin, RAB GTPase binding effector protein 2	Mus musculus	99-103
31984590-1	2020	Folate receptors (FRs) are membrane proteins involved in folic acid uptake, and the alpha isoform (FR-a) is overexpressed in ovarian and endometrial cancer cells.	Folic Acid	57-67	rabaptin, RAB GTPase binding effector protein 2	Mus musculus	99-103
32024651-8	2020	Best agreement with SDAI remission occurred at PGA cut-offs of 1.5 and 2.0, while agreement decreased with higher PGA (CART: optimal agreement at PGA<=1.6 cm; sensitivity of PGA<=1.5 95%).	Folic Acid	114-117	CART prepropeptide	Homo sapiens	119-123
31981855-0	2020	Monitoring biomolecular interaction between folic acid and bovine serum albumin.	Folic Acid	44-54	albumin	Homo sapiens	66-79
31981855-2	2020	The binding mechanism of folic acid to free bovine serum albumin (BSA) was studied using fluorescence, while the biomolecular interaction between confined-BSA and free folic acid was assessed by electrochemical methods and surface plasmon resonance.	Folic Acid	25-35	albumin	Homo sapiens	51-64
32242053-0	2020	Author Correction: PHF14: an innate inhibitor against the progression of renal fibrosis following folic acid-induced kidney injury.	Folic Acid	98-108	PHD finger protein 14	Homo sapiens	19-24
32266401-8	2020	Similarly, correlations between CRP and serum folate ranged from -0.13 to 0.08, and correlations between AGP and serum folate between -0.21 and 0.02.	Folic Acid	46-52	C-reactive protein	Homo sapiens	32-35
32154964-5	2020	Several years ago, folate-appended beta-CyD (Fol-c1 -beta-CyD) was developed as an FRalpha-targeting drug carrier, but its efficacy as a treatment for EOC remains to be determined.	Folic Acid	19-25	rabaptin, RAB GTPase binding effector protein 2	Mus musculus	83-90
32024651-8	2020	Best agreement with SDAI remission occurred at PGA cut-offs of 1.5 and 2.0, while agreement decreased with higher PGA (CART: optimal agreement at PGA<=1.6 cm; sensitivity of PGA<=1.5 95%).	Folic Acid	114-117	CART prepropeptide	Homo sapiens	119-123
31858458-4	2020	METHODS: The P-gp overexpressing KB-ChR-8-5 cells were incubated with the FGB nanoconjugate, bilirubin, or GNPs.	Folic Acid	74-77	ATP binding cassette subfamily B member 1	Homo sapiens	13-17
32162086-0	2020	PtNPs-GNPs-MWCNTs-beta-CD nanocomposite modified glassy carbon electrode for sensitive electrochemical detection of folic acid.	Folic Acid	116-126	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	18-25
31858458-12	2020	Hence, folate-gold-bilirubin nanoparticles could be a promising agent for inducing apoptosis in P-gp-overexpressing drug-resistant cancer cells.	Folic Acid	7-28	ATP binding cassette subfamily B member 1	Homo sapiens	96-100
32146711-11	2020	CONCLUSION: MTR 2756A>G and MTRR 66A>G polymorphisms related to folate metabolism might be genetic markers for risk of hypertension in the Korean population.	Folic Acid	64-70	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	28-32
31492214-6	2020	After folic acid (FA) conjugating to the surface of the PSMA dots, FA-dots were obtained.	Folic Acid	6-16	folate hydrolase 1	Homo sapiens	56-60
31864233-0	2020	CBS gene polymorphism and promoter methylation-mediating effects on the efficacy of folate therapy in patients with hyperhomocysteinemia.	Folic Acid	84-90	cystathionine beta-synthase	Homo sapiens	0-3
31864233-3	2020	The present study aimed to explore CBS promoter methylation-mediating effects on the efficacy of folate treatment for HHcy.	Folic Acid	97-103	cystathionine beta-synthase	Homo sapiens	35-38
31864233-10	2020	Additionally, baseline CBS promoter methylation mediated 33.39% of the effect of rs2851391 on the efficacy of folate treatment for HHcy (ACME [average causal mediation effects]: -0.05, 95% CI = -0.11 to 0.00, p = 0.046).	Folic Acid	110-116	cystathionine beta-synthase	Homo sapiens	23-26
31864233-12	2020	There were potentially causal effects of genetic, epigenetic variations at the CBS rs2851391 locus on the efficacy of HHcy therapy with folate.	Folic Acid	136-142	cystathionine beta-synthase	Homo sapiens	79-82
31893979-0	2020	Folic acid receptor-targeted solid lipid nanoparticles to enhance cytotoxicity of letrozole through induction of caspase-3 dependent-apoptosis for breast cancer treatment.	Folic Acid	0-10	caspase 3	Homo sapiens	113-122
31883219-7	2020	Patients with higher percentages of CCR7lo PD-1hi subsets presented with higher PGA VAS (P = .000), muscle VAS (P = .000), as well as serum creatinine kinase (CK) levels (P = .000) than those with lower percentages of CCR7lo PD-1hi subsets.	Folic Acid	80-83	C-C motif chemokine receptor 7	Homo sapiens	36-40
32280743-1	2020	In this study, the CAR-like multivalent aptamer nanoparticles (X-polymers) were assembled with the dimer of murine CD28 RNA aptamer (CD28Apt7), the tetramer of CTLA-4 (cytotoxic T-lymphocyte-associated protein 4) RNA aptamer (Del60), and a folic acid labeled ssDNA fragment in a stable nucleic acid three-way junction scaffold (3WJ).	Folic Acid	240-250	nuclear receptor subfamily 1, group I, member 3	Mus musculus	19-22
31794432-0	2020	Impaired folate 1-carbon metabolism causes formate-preventable hydrocephalus in glycine decarboxylase-deficient mice.	Folic Acid	9-15	glycine decarboxylase	Mus musculus	80-101
31794432-3	2020	Gldc functions in the glycine cleavage system, a mitochondrial component of folate metabolism, whose malfunction results in accumulation of glycine and diminished supply of glycine-derived 1-carbon units to the folate cycle.	Folic Acid	76-82	glycine decarboxylase	Mus musculus	0-4
31794432-3	2020	Gldc functions in the glycine cleavage system, a mitochondrial component of folate metabolism, whose malfunction results in accumulation of glycine and diminished supply of glycine-derived 1-carbon units to the folate cycle.	Folic Acid	211-217	glycine decarboxylase	Mus musculus	0-4
31794432-6	2020	Furthermore, ventriculomegaly was rescued by genetic ablation of 5,10-methylene tetrahydrofolate reductase (Mthfr), which results in retention of 1-carbon groups in the folate cycle at the expense of transfer to the methylation cycle.	Folic Acid	90-96	methylenetetrahydrofolate reductase	Mus musculus	108-113
32062449-5	2020	The molecular docking calculations were executed on two of the most bacterial targets, ATP-binding sites of DNA gyrase B, and the folate-binding site of DHFR enzymes.	Folic Acid	130-136	dihydrofolate reductase	Escherichia coli	153-157
31883219-9	2020	Meanwhile, both the CCR7lo PD-1hi subset and intracellular IL-21 expression in IIM patients showed significantly positive correlation with PGA VAS, muscle VAS and serum CK levels.	Folic Acid	139-142	C-C motif chemokine receptor 7	Homo sapiens	20-24
31935457-7	2020	In the >=60 age group; folate and vitamin B12 positively correlated with rTL and vitamin B12 with mtCN.	Folic Acid	23-29	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	89-92
31994802-10	2020	The transcriptomic analysis revealed that folic acid treatment regulated many key metabolic-related genes (DGAT2, ALOX5, LAP3, GPAT3, GGH, ALDOA, TKT) and pathways (glycolysis, folate biosynthesis, glutathione metabolism, etc.)	Folic Acid	42-52	arachidonate 5-lipoxygenase	Bos taurus	114-119
31994802-10	2020	The transcriptomic analysis revealed that folic acid treatment regulated many key metabolic-related genes (DGAT2, ALOX5, LAP3, GPAT3, GGH, ALDOA, TKT) and pathways (glycolysis, folate biosynthesis, glutathione metabolism, etc.)	Folic Acid	42-52	glycerol-3-phosphate acyltransferase 3	Bos taurus	127-132
31994802-10	2020	The transcriptomic analysis revealed that folic acid treatment regulated many key metabolic-related genes (DGAT2, ALOX5, LAP3, GPAT3, GGH, ALDOA, TKT) and pathways (glycolysis, folate biosynthesis, glutathione metabolism, etc.)	Folic Acid	42-52	aldolase, fructose-bisphosphate A	Bos taurus	139-144
32072346-5	2020	RESULTS: The folate conjugated dual drug formulations (FCGNPs) gave better results in suppressing the pgy-1 gene and also showed higher cellular uptake, cytotoxicity, apoptosis, and cell cycle arrest.	Folic Acid	13-19	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	102-107
31721048-0	2020	Folic Acid Protects Rat Cerebellum Against Oxidative Damage Caused by Homocysteine: the Expression of Bcl-2, Bax, and Caspase-3 Apoptotic Genes.	Folic Acid	0-10	BCL2, apoptosis regulator	Rattus norvegicus	102-107
31721048-2	2020	Considering the antioxidative properties of folic acid and its involvement as a cofactor for methionine synthase (MS) in the homocysteine-methionine cycle, the aim of this study was to evaluate the mechanism associated with homocysteine-induced toxicity and its prevention with folic acid supplementation.	Folic Acid	44-54	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	93-112
31721048-12	2020	Moreover, cerebellar MS, CBS enzyme activity, GSH, and GSH/GSH ratio increased following folic acid treatment.	Folic Acid	89-99	cystathionine beta synthase	Rattus norvegicus	25-28
32121219-6	2020	Multivariate analysis found significant negative associations between 4M-EDR and RBC folate (p < 0.001, beta = -0.19), serum folate (p = 0.045, beta = -0.08) and homocysteine levels (p < 0.001, beta = -0.28).	Folic Acid	85-91	paternally expressed 10	Homo sapiens	73-76
29848222-2	2020	Excess (10-fold) intakes of folic acid in the gestational diet have been linked to increased food intake and obesity in male rat offspring post-weaning.Objective: The present study examined the effects of folic acid content in gestational diets on the development and function of two hypothalamic neuronal populations, neuropeptide Y (NPY) and pro-opiomelanocortin (POMC), within food intake regulatory pathways of male Wistar rat offspring at birth and post-weaning.Results: Folic acid fed at 5.0-fold above recommended levels (5RF) to Wistar dams during pregnancy increased the number of mature NPY-positive neurons in the hypothalamus of male offspring, compared to control (RF), 0RF, 2.5RF, and 10RF at birth.	Folic Acid	28-38	neuropeptide Y	Rattus norvegicus	319-333
31656209-0	2020	Simultaneous supplementation with iron and folic acid can affect Slc11a2 and Slc46a1 transcription and metabolite concentrations in rats.	Folic Acid	43-53	solute carrier family 11 member 2	Rattus norvegicus	65-72
31472292-0	2020	IgE-mediated anaphylactic reaction against free synthetic folic acid and methyl folate.	Folic Acid	58-68	immunoglobulin heavy constant epsilon	Homo sapiens	0-3
31918266-10	2020	RESULTS: Our study found increasing miR-27a expression in serum of normal, high-grade squamous intraepithelial lesion (HSIL), and SCC tissues (in order of magnitude), which trend was negatively correlated with serum folate content.	Folic Acid	216-222	microRNA 27a	Homo sapiens	36-43
31918266-11	2020	Further, there were significant differences in cellular miR-27a expression between 200 nM and 500 nM folate concentrations, with higher folate concentrations showing lower proliferation, migration, and invasion in SCC.	Folic Acid	101-107	microRNA 27a	Homo sapiens	56-63
31918266-11	2020	Further, there were significant differences in cellular miR-27a expression between 200 nM and 500 nM folate concentrations, with higher folate concentrations showing lower proliferation, migration, and invasion in SCC.	Folic Acid	136-142	microRNA 27a	Homo sapiens	56-63
31918266-13	2020	CONCLUSION: There is a significant association between miR-27a expression and folate during cervical carcinoma progression.	Folic Acid	78-84	microRNA 27a	Homo sapiens	55-62
29848222-2	2020	Excess (10-fold) intakes of folic acid in the gestational diet have been linked to increased food intake and obesity in male rat offspring post-weaning.Objective: The present study examined the effects of folic acid content in gestational diets on the development and function of two hypothalamic neuronal populations, neuropeptide Y (NPY) and pro-opiomelanocortin (POMC), within food intake regulatory pathways of male Wistar rat offspring at birth and post-weaning.Results: Folic acid fed at 5.0-fold above recommended levels (5RF) to Wistar dams during pregnancy increased the number of mature NPY-positive neurons in the hypothalamus of male offspring, compared to control (RF), 0RF, 2.5RF, and 10RF at birth.	Folic Acid	28-38	neuropeptide Y	Rattus norvegicus	335-338
29848222-2	2020	Excess (10-fold) intakes of folic acid in the gestational diet have been linked to increased food intake and obesity in male rat offspring post-weaning.Objective: The present study examined the effects of folic acid content in gestational diets on the development and function of two hypothalamic neuronal populations, neuropeptide Y (NPY) and pro-opiomelanocortin (POMC), within food intake regulatory pathways of male Wistar rat offspring at birth and post-weaning.Results: Folic acid fed at 5.0-fold above recommended levels (5RF) to Wistar dams during pregnancy increased the number of mature NPY-positive neurons in the hypothalamus of male offspring, compared to control (RF), 0RF, 2.5RF, and 10RF at birth.	Folic Acid	28-38	neuropeptide Y	Rattus norvegicus	597-600
31636139-0	2019	Cellular mechanisms underlying Pax3-related neural tube defects and their prevention by folic acid.	Folic Acid	88-98	paired box 3	Mus musculus	31-35
32019154-0	2020	Food Intervention with Folate Reduces TNF-alpha and Interleukin Levels in Overweight and Obese Women with the MTHFR C677T Polymorphism: A Randomized Trial.	Folic Acid	23-29	tumor necrosis factor	Homo sapiens	38-47
32019154-11	2020	Food intervention with folate from vegetables increased folic acid levels and reduced interleukins, TNF-alpha, and Hcy levels, mainly for individuals with the TT genotype.	Folic Acid	23-29	tumor necrosis factor	Homo sapiens	100-109
31970547-6	2020	The functionalization of the block copolymer carriers with a targeting folate group enhanced the tumor cell growth inhibition and total apoptotic rates induced by CytC.	Folic Acid	71-77	cytochrome c, somatic	Homo sapiens	163-167
32296026-5	2020	We utilized a folate-modified lipoplex comprising a folate-modified liposome (F-PLP) delivering a BIM-S plasmid to target both lung cancer cells and FRbeta-positive macrophages in the tumor microenvironment.	Folic Acid	14-20	rabaptin, RAB GTPase binding effector protein 2	Mus musculus	149-155
32296026-5	2020	We utilized a folate-modified lipoplex comprising a folate-modified liposome (F-PLP) delivering a BIM-S plasmid to target both lung cancer cells and FRbeta-positive macrophages in the tumor microenvironment.	Folic Acid	52-58	rabaptin, RAB GTPase binding effector protein 2	Mus musculus	149-155
32051732-0	2020	Pretreatment with Roxadustat (FG-4592) Attenuates Folic Acid-Induced Kidney Injury through Antiferroptosis via Akt/GSK-3beta/Nrf2 Pathway.	Folic Acid	50-60	thymoma viral proto-oncogene 1	Mus musculus	111-114
32051732-0	2020	Pretreatment with Roxadustat (FG-4592) Attenuates Folic Acid-Induced Kidney Injury through Antiferroptosis via Akt/GSK-3beta/Nrf2 Pathway.	Folic Acid	50-60	nuclear factor, erythroid derived 2, like 2	Mus musculus	125-129
31941442-9	2020	Folic acid treatment effectively increased the levels of monoamine neurotransmitters, BDNF and beta-endorphin, interleukin-6 and homocysteine levels were also significantly suppressed by folic acid administration.	Folic Acid	0-10	interleukin 6	Rattus norvegicus	111-124
31941442-9	2020	Folic acid treatment effectively increased the levels of monoamine neurotransmitters, BDNF and beta-endorphin, interleukin-6 and homocysteine levels were also significantly suppressed by folic acid administration.	Folic Acid	187-197	interleukin 6	Rattus norvegicus	111-124
31792824-2	2020	The MR1 ligands identified to date are limited to derivatives and intermediates of the riboflavin and folate biosynthesis pathways and their presentation is therefore thought to be an indicator of infection by microbial species that can synthesize riboflavin.	Folic Acid	102-108	major histocompatibility complex, class I-related	Homo sapiens	4-7
31713293-5	2020	CONCLUSIONS: Owing to the rs1979277 A allele, which reduces the cytoplasmic SHMT activity and has a higher frequency in controls than in NSCL/P cases, we hypothesized that a low enzyme activity may increase the cytoplasmic concentration of folates and, therefore, explain the protective role against OFCs.	Folic Acid	240-247	nescient helix-loop-helix 1	Homo sapiens	137-141
30942626-3	2019	The present study involves the preparation and characterization of eudragit S100-coated mini-capsules filled with chitosan nanoparticles-unconjugated and folic acid (FA)-conjugated encapsulating caspase 3 activator (7-hydroxystaurosporine).	Folic Acid	154-164	caspase 3	Homo sapiens	195-204
32096475-10	2019	Folate treatment was significantly associated with improvement in disease parameters, reduced presence of the pro-inflammatory cytokines TNF-alpha and CXCL8 and LC3B expression, and increased IL-22 levels in a dose-dependent manner.	Folic Acid	0-6	tumor necrosis factor	Rattus norvegicus	137-146
32096475-10	2019	Folate treatment was significantly associated with improvement in disease parameters, reduced presence of the pro-inflammatory cytokines TNF-alpha and CXCL8 and LC3B expression, and increased IL-22 levels in a dose-dependent manner.	Folic Acid	0-6	interleukin 22	Rattus norvegicus	192-197
31772242-11	2019	miR-483 was found to be increased with all conditions of folate and B12 in both F1 and F2 generations, however, deficient conditions of B12 led to an increase in the expression of miR-221 in both F1 and F2 generations.	Folic Acid	57-63	microRNA 483	Mus musculus	0-7
29848222-5	2020	Increased body weight and food intake at 9-weeks post-weaning were accompanied by a reduced activation of POMC neurons in the arcuate nucleus (ARC).Conclusion: Gestational folic acid content modulates expression of mature hypothalamic NPY-positive neurons at birth and activation of POMC-positive neurons at 9-weeks post-weaning in the ARC of male Wistar rat offspring which may contribute to higher body weight and food intake later in life.	Folic Acid	172-182	neuropeptide Y	Rattus norvegicus	235-238
32674237-7	2020	In the red furu group, but not in tofu group, serum concentrations of B-12 and folate were negatively associated with homocysteine, and B-12 was positively associated with folate.	Folic Acid	172-178	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	136-140
31729941-0	2020	New Folate-Modified Human Serum Albumin Conjugated to Cationic Lipid Carriers for Dual Targeting of Mitoxantrone against Breast Cancer.	Folic Acid	4-10	albumin	Homo sapiens	32-39
31729941-1	2020	AIMS: In the present work, folic acid-modified human serum albumin conjugated to cationic solid lipid nanoparticles were synthesized as nanocarriers of mitoxantrone for the treatment of breast cancer.	Folic Acid	27-37	albumin	Homo sapiens	59-66
32071495-7	2020	Weekly IFA supplementation in anemic primigravidas resulted in significantly reduced levels of hematological markers (p &lt; 0.01); whereas non-anemic primigravidas showed lower ferritin and iron levels, and higher soluble transferrin receptor levels (p &lt; 0.05).	Folic Acid	7-10	transferrin	Homo sapiens	223-234
32071495-9	2020	A significantly decreased placental ferritin expression (p &lt; 0.05); and an increased placental transferrin expression was seen in anemic primigravidas supplemented with weekly IFA tablets.	Folic Acid	179-182	transferrin	Homo sapiens	98-109
31851787-2	2020	In this article, we focused on the interactions between 13 candidate genes within folate, homocysteine, and transsulfuration pathways for potential association with CTD risk.	Folic Acid	82-88	CTD	Homo sapiens	165-168
32042737-1	2019	Background: Reduced folate carrier 1 (RFC1) gene is a candidate for susceptibility to nonsyndromic cleft lip with or without cleft palate (NSCL/P).	Folic Acid	20-26	nescient helix-loop-helix 1	Homo sapiens	139-143
31558761-0	2019	Association between BHMT and CBS gene promoter methylation with the efficacy of folic acid therapy in patients with hyperhomocysteinemia.	Folic Acid	80-90	cystathionine beta-synthase	Homo sapiens	29-32
31558761-3	2019	The present study is performed to explore the association between the methylation levels in the promoter regions of the BHMT and CBS genes and the efficacy of folic acid therapy in patient with hyperhomocysteinemia (HHcy).	Folic Acid	159-169	cystathionine beta-synthase	Homo sapiens	129-132
31558761-10	2019	These studies suggest that lower levels of BHMT and CBS methylation are all predictors of failure in folic acid therapy for HHcy.	Folic Acid	101-111	cystathionine beta-synthase	Homo sapiens	52-55
31636139-4	2019	Pax3 mutant (splotch; Sp2H ) mice provide a model in which NTDs are preventable by folic acid and exacerbated by maternal folate deficiency.	Folic Acid	83-93	paired box 3	Mus musculus	0-4
31636139-4	2019	Pax3 mutant (splotch; Sp2H ) mice provide a model in which NTDs are preventable by folic acid and exacerbated by maternal folate deficiency.	Folic Acid	122-128	paired box 3	Mus musculus	0-4
31636139-12	2019	We propose that the cell-cycle-promoting effect of folic acid compensates for the loss of Pax3 and thereby prevents cranial NTDs.	Folic Acid	51-61	paired box 3	Mus musculus	90-94
31698794-3	2019	In this study, we successfully conjugated folate to polyethylene glycol 100 monostearate as film-forming material and further prepared methotrexate (MTX) and catalase (CAT) co-encapsulated liposomes, herein, shortened to FOL-MTX&amp;CAT-L, that could actively target to activated macrophages.	Folic Acid	42-48	catalase	Mus musculus	158-166
31722724-5	2019	We demonstrated that an increase in H2AK119ub1 downregulated expression of the neural tube closure-related genes Cdx2, Nes, Pax6, and Gata4 in mouse embryonic stem cells under folate deficiency conditions.	Folic Acid	176-182	paired box 6	Mus musculus	124-128
31722724-5	2019	We demonstrated that an increase in H2AK119ub1 downregulated expression of the neural tube closure-related genes Cdx2, Nes, Pax6, and Gata4 in mouse embryonic stem cells under folate deficiency conditions.	Folic Acid	176-182	GATA binding protein 4	Mus musculus	134-139
31719518-1	2019	D4 dopamine receptor (D4R) activation uniquely promotes methylation of plasma membrane phospholipids, utilizing folate-derived methyl groups provided by methionine synthase (MS).	Folic Acid	112-118	methionine synthase	Cricetulus griseus	153-172
31698794-3	2019	In this study, we successfully conjugated folate to polyethylene glycol 100 monostearate as film-forming material and further prepared methotrexate (MTX) and catalase (CAT) co-encapsulated liposomes, herein, shortened to FOL-MTX&amp;CAT-L, that could actively target to activated macrophages.	Folic Acid	42-48	catalase	Mus musculus	168-171
31509012-3	2019	Although expression of C1r in untreated wild-type (WT) mice was higher in the liver compared with kidney tissue, administration of folic acid (FA) led to upregulation of C1r mRNA and protein levels only in kidney tissue.	Folic Acid	131-141	complement component 1, r subcomponent A	Mus musculus	170-173
31853248-10	2019	Angiotensin II receptor type 1 (AGTR1) levels in the kidney tissue increased in the Wistar folate group.	Folic Acid	91-97	angiotensin II receptor, type 1b	Rattus norvegicus	0-30
31612177-1	2019	Offspring of dams exposed to excess folic acid during the perigestational period have been shown by us to be predisposed to metabolic dysfunction revealed by hyperglycemia, glucose intolerance, increased insulin and decreased adiponectin in late adulthood.	Folic Acid	36-46	insulin	Homo sapiens	204-211
31612177-1	2019	Offspring of dams exposed to excess folic acid during the perigestational period have been shown by us to be predisposed to metabolic dysfunction revealed by hyperglycemia, glucose intolerance, increased insulin and decreased adiponectin in late adulthood.	Folic Acid	36-46	adiponectin, C1Q and collagen domain containing	Homo sapiens	226-237
31612177-9	2019	Our data suggest that high folic acid exposure during the perigestational period caused morphologic and genic alterations related to insulin resistant states indicating that this intervention may act as an effective programmer of long-term metabolic dysfunction.	Folic Acid	27-37	insulin	Homo sapiens	133-140
31604165-11	2019	VD and folic acid supplementation may be explored further as a possible therapeutic option for POR with immune and metabolic etiologies.	Folic Acid	7-17	cytochrome p450 oxidoreductase	Homo sapiens	95-98
31500030-2	2019	Briefly, DOX was conjugated to bovine serum albumin (BSA) and the complex was treated with lactobionic acid (LA) as well as folic acid (FA) to enhance drug endocytosis and targeting selectivity.	Folic Acid	124-134	albumin	Homo sapiens	38-51
31853248-10	2019	Angiotensin II receptor type 1 (AGTR1) levels in the kidney tissue increased in the Wistar folate group.	Folic Acid	91-97	angiotensin II receptor, type 1b	Rattus norvegicus	32-37
31737034-8	2019	ALDH1L1, one of the folate-metabolizing enzymes, serves a regulatory function in folate metabolism restricting the flux of one-carbon groups through biosynthetic processes.	Folic Acid	20-26	aldehyde dehydrogenase 1 family member L1	Homo sapiens	0-7
31737034-8	2019	ALDH1L1, one of the folate-metabolizing enzymes, serves a regulatory function in folate metabolism restricting the flux of one-carbon groups through biosynthetic processes.	Folic Acid	81-87	aldehyde dehydrogenase 1 family member L1	Homo sapiens	0-7
31737034-11	2019	ALDH1L1 has much higher frequency of non-synonymous exonic SNPs than most other genes for folate enzymes.	Folic Acid	90-96	aldehyde dehydrogenase 1 family member L1	Homo sapiens	0-7
31737034-13	2019	The effects of these SNPs on the enzyme is not clear but studies indicate that some coding and non-coding ALDH1L1 SNPs are associated with altered risk of certain cancer types and it is also likely that specific haplotypes define the metabolic response to dietary folate.	Folic Acid	264-270	aldehyde dehydrogenase 1 family member L1	Homo sapiens	106-113
31737034-14	2019	This review discusses the role of ALDH1L1 in folate metabolism and etiology of diseases with the focus on non-synonymous coding ALDH1L1 SNPs and their effects on the enzyme structure/function, metabolic role and association with cancer.	Folic Acid	45-51	aldehyde dehydrogenase 1 family member L1	Homo sapiens	34-41
31619709-0	2019	The contribution of dietary and plasma folate and cobalamin to levels of angiopoietin-1, angiopoietin-2 and Tie-2 receptors depend on vascular endothelial growth factor status of primary breast cancer patients.	Folic Acid	39-45	vascular endothelial growth factor A	Homo sapiens	134-168
31619709-7	2019	Dietary intake of folate and cobalamin showed a significant inverse correlation with plasma ANG-1 and ANG-2 (P < 0.05), particularly in subjects with estrogen-receptor positive tumors or low plasma VEGF-C.	Folic Acid	18-24	vascular endothelial growth factor C	Homo sapiens	198-204
31619709-11	2019	Folic acid treatment resulted in dose-dependent down-regulations on ANGPT1 and ANGPT1/ANGPT2 ratio but VEGF and ANGPT2/VEGF were upregulated at folic acid >20 muM.	Folic Acid	0-10	vascular endothelial growth factor A	Homo sapiens	103-107
31619709-11	2019	Folic acid treatment resulted in dose-dependent down-regulations on ANGPT1 and ANGPT1/ANGPT2 ratio but VEGF and ANGPT2/VEGF were upregulated at folic acid >20 muM.	Folic Acid	0-10	vascular endothelial growth factor A	Homo sapiens	119-123
31619709-11	2019	Folic acid treatment resulted in dose-dependent down-regulations on ANGPT1 and ANGPT1/ANGPT2 ratio but VEGF and ANGPT2/VEGF were upregulated at folic acid >20 muM.	Folic Acid	0-10	latexin	Homo sapiens	159-162
31619709-11	2019	Folic acid treatment resulted in dose-dependent down-regulations on ANGPT1 and ANGPT1/ANGPT2 ratio but VEGF and ANGPT2/VEGF were upregulated at folic acid >20 muM.	Folic Acid	144-154	vascular endothelial growth factor A	Homo sapiens	119-123
31619709-12	2019	Studying the contributing role of dietary folate to pro-angiogenic biomarkers in breast cancer patients can infer the preventive role of folate in the ANGs/VEGF-C-dependent cascade of tumor metastasis.	Folic Acid	42-48	vascular endothelial growth factor C	Homo sapiens	156-162
31619709-12	2019	Studying the contributing role of dietary folate to pro-angiogenic biomarkers in breast cancer patients can infer the preventive role of folate in the ANGs/VEGF-C-dependent cascade of tumor metastasis.	Folic Acid	137-143	vascular endothelial growth factor C	Homo sapiens	156-162
31366217-5	2019	Hyperhomocysteinemia potentiated T2DM-induced mononuclear cell, monocyte, inflammatory monocyte (CD11b+Ly6C+), and M1 macrophage differentiation in periphery and aorta, which were rescued by folic acid-based homocysteine-lowering therapy.	Folic Acid	191-201	integrin alpha M	Mus musculus	97-102
31619709-13	2019	By contrast, high concentrations of folic acid in vitro supported VEGF-C-dependent ANGPT2 overexpression might potentiate micro-lymphatic vessel development to support malignant cell dissemination.	Folic Acid	36-46	vascular endothelial growth factor C	Homo sapiens	66-72
31737547-4	2019	Additionally, infants and children with congenital heart defects often show disorders in folate metabolism (low folate, higher homocysteine, or low vitamin B12).	Folic Acid	89-95	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	156-159
31187858-0	2019	Lack of historical evidence to support folic acid exacerbation of the neuropathy caused by vitamin B12 deficiency.	Folic Acid	39-49	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	99-102
31482954-1	2019	OBJECTIVE: To investigate the association of the genetic variants of the folate metabolism genes (MTHFR C677T; MTHFR A1298C; MTR A2756G; MTRR A66G and RFC-1 A80G) with the development of polycystic ovary syndrome (PCOS).	Folic Acid	73-79	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	137-141
29798726-2	2019	Our research has identified a unique cerebral folate system in which depletion of CSF 10-formyl-tetrahydrofolate-dehydrogenase (FDH) is associated with cortical progenitor cell-cycle arrest in hydrocephalic Texas (H-Tx) rats.	Folic Acid	46-52	aldehyde dehydrogenase 1 family, member L1	Rattus norvegicus	128-131
29798726-4	2019	Adding FDH to this CSF prevented aberrant proliferation indicating a regulatory function of FDH on CSF folate concentration.	Folic Acid	103-109	aldehyde dehydrogenase 1 family, member L1	Rattus norvegicus	7-10
29798726-4	2019	Adding FDH to this CSF prevented aberrant proliferation indicating a regulatory function of FDH on CSF folate concentration.	Folic Acid	103-109	aldehyde dehydrogenase 1 family, member L1	Rattus norvegicus	92-95
29798726-6	2019	Co-localization of FDH, FRalpha and folate suggests important functions of FDH in cerebral folate transport, buffering and function.	Folic Acid	36-42	aldehyde dehydrogenase 1 family, member L1	Rattus norvegicus	75-78
29798726-6	2019	Co-localization of FDH, FRalpha and folate suggests important functions of FDH in cerebral folate transport, buffering and function.	Folic Acid	91-97	aldehyde dehydrogenase 1 family, member L1	Rattus norvegicus	19-22
29798726-6	2019	Co-localization of FDH, FRalpha and folate suggests important functions of FDH in cerebral folate transport, buffering and function.	Folic Acid	91-97	aldehyde dehydrogenase 1 family, member L1	Rattus norvegicus	75-78
29798726-8	2019	FDH appears to buffer available folate to control arachnoid proliferation and function.	Folic Acid	32-38	aldehyde dehydrogenase 1 family, member L1	Rattus norvegicus	0-3
31187858-8	2019	The likely cause of the neurological problems encountered is the development of vitamin B12 neuropathy when pernicious anemia was treated with high-dosage folic acid before vitamin B12 was widely available in the early 1950s.	Folic Acid	155-165	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	88-91
30614647-7	2019	A higher folate: vitamin B12 ratio was associated with higher glucose and a higher risk of GDM (OR 3.08; 95% CI 1.63-5.83).	Folic Acid	9-15	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	25-28
31165994-7	2019	The COX2 -765G>C polymorphism showed peculiar associations with CAD according to the presence of hyperlipidemia and plasma folate levels.	Folic Acid	123-129	prostaglandin-endoperoxide synthase 2	Homo sapiens	4-8
30238853-0	2019	Multispectroscopic studies of the interaction of folic acid with glycated human serum albumin.	Folic Acid	49-59	albumin	Homo sapiens	80-93
30238853-1	2019	The interaction between glycated human serum albumin (gHSA) and folic acid (FA) was investigated by various spectroscopic techniques, such as fluorescence, circular dichroism, UV-vis absorption spectroscopy and electrophoretic light scattering technique.	Folic Acid	64-74	albumin	Homo sapiens	39-52
30614647-8	2019	The presence of both a higher folate: vitamin B12 ratio and advanced age further increased the OR to 2.13 (95% CI 1.09-4.15) with a significant additive interaction.	Folic Acid	30-36	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	46-49
30614647-9	2019	Furthermore, a higher folate: vitamin B12 ratio and a higher prepregnancy body mass index (pp-BMI) were synergistically associated with an increased risk of GDM (OR 3.03; 95% CI 1.40-6.57).	Folic Acid	22-28	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	38-41
30614647-10	2019	CONCLUSIONS: An imbalance between folate and vitamin B12 , represented by a higher folate: vitamin B12 ratio, was highly associated with GDM risk, and this association could be further modified by maternal age and pp-BMI.	Folic Acid	34-40	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	99-102
30614647-10	2019	CONCLUSIONS: An imbalance between folate and vitamin B12 , represented by a higher folate: vitamin B12 ratio, was highly associated with GDM risk, and this association could be further modified by maternal age and pp-BMI.	Folic Acid	83-89	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	53-56
30649001-0	2019	A Student-Led, Multifaceted Intervention to Decrease Unnecessary Folate Ordering in the Inpatient Setting.	Folic Acid	65-71	small integral membrane protein 10 like 2A	Homo sapiens	10-13
30541139-9	2019	The increased kidney expression of MAGED2 mRNA and protein was confirmed by qRT-PCR and western blot, respectively, in murine folic acid- and cisplatin-induced AKI.	Folic Acid	126-136	MAGE family member D2	Mus musculus	35-41
29587542-10	2019	Conclusions: This study suggested that maternal folic acid supplementation during pregnancy affects airway remodeling and increases the allergic responses induced by ovalbumin challenge in offspring.	Folic Acid	48-58	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	166-175
31405972-2	2019	Folate transport is mediated by 3 major pathways, reduced folate carrier (RFC), proton-coupled folate transporter (PCFT), and folate receptor alpha (FRalpha/Folr1), known to be regulated by ligand-activated nuclear receptors.	Folic Acid	0-6	rabaptin, RAB GTPase binding effector protein 2	Mus musculus	149-156
31405972-3	2019	Cerebral folate delivery primarily occurs at the choroid plexus through FRalpha and PCFT; inactivation of these transport systems can result in very low folate levels in the cerebrospinal fluid causing childhood neurodegenerative disorders.	Folic Acid	9-15	rabaptin, RAB GTPase binding effector protein 2	Mus musculus	72-79
31467993-5	2019	Decreased MBD2 and MECP2 were discovered upon treatment of SHSY5Y cells with a 2x folic acid dose.	Folic Acid	82-92	methyl-CpG binding protein 2	Homo sapiens	19-24
31496684-0	2019	Intravesical delivery of rapamycin via folate-modified liposomes dispersed in thermo-reversible hydrogel.	Folic Acid	39-45	regulatory associated protein of MTOR, complex 1	Mus musculus	25-34
31165884-8	2019	RESULTS: The categorical model resulted in 6 DMPs, which are all negatively associated with folate intake, annotated to FAM64A, WRAP73, FRMD8, CUX1, and LCN8 genes, which have a role in cellular processes including centrosome localization, cell proliferation, and tumorigenesis.	Folic Acid	92-98	PICALM interacting mitotic regulator	Homo sapiens	120-126
31165884-8	2019	RESULTS: The categorical model resulted in 6 DMPs, which are all negatively associated with folate intake, annotated to FAM64A, WRAP73, FRMD8, CUX1, and LCN8 genes, which have a role in cellular processes including centrosome localization, cell proliferation, and tumorigenesis.	Folic Acid	92-98	WD repeat containing, antisense to TP73	Homo sapiens	128-134
31165884-8	2019	RESULTS: The categorical model resulted in 6 DMPs, which are all negatively associated with folate intake, annotated to FAM64A, WRAP73, FRMD8, CUX1, and LCN8 genes, which have a role in cellular processes including centrosome localization, cell proliferation, and tumorigenesis.	Folic Acid	92-98	FERM domain containing 8	Homo sapiens	136-141
31296192-9	2019	Serum folate was negatively correlated with hs-CRP, TNF-alpha, and IL-6 (P &lt; 0.05).	Folic Acid	6-12	interleukin 6	Homo sapiens	67-71
31250067-4	2019	The strong affinity of the surface-confined beta-cyclodextrin for folic acid, together with favorable electron transfer characteristics, resulted in a sensor with a detection limit of 1 nM for folic acid and a linear response up to 10 muM.	Folic Acid	66-76	latexin	Homo sapiens	235-238
31250067-4	2019	The strong affinity of the surface-confined beta-cyclodextrin for folic acid, together with favorable electron transfer characteristics, resulted in a sensor with a detection limit of 1 nM for folic acid and a linear response up to 10 muM.	Folic Acid	193-203	latexin	Homo sapiens	235-238
31241900-2	2019	Here, we propose a rational design of a ternary nanoassembly (SAP) composed of nonionic amphiphilic beta-cyclodextrins (amphiphilic CD) incorporating pheophorbide (Pheo) as a phototherapeutic and an adamantanyl-folic acid conjugate (Ada-FA) to target tumor cells overexpressing alpha-folate receptor (FR-alpha(+)).	Folic Acid	211-221	SH2 domain containing 1A	Homo sapiens	62-65
31209768-0	2019	Associations of MTRR and TSER polymorphisms related to folate metabolism with susceptibility to metabolic syndrome.	Folic Acid	55-61	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	16-20
30955184-8	2019	Folate was significantly positively associated with invasive and estrogen receptor-positive/progesterone receptor-positive breast cancer, and this association was suggestively stronger for bloods collected post-fortification.	Folic Acid	0-6	estrogen receptor 1	Homo sapiens	65-82
30952042-4	2019	We introduce folate-functionalized bioactive glass nanoparticle BGN(F) that can bind to pro-inflammatory cells to endocytose and release ions.	Folic Acid	13-19	biglycan	Mus musculus	64-67
31344387-4	2019	Postnatal factors including energy excess, folate, vitamin A, conjugated linoleic acid and leptin may also affect POMC methylation.	Folic Acid	43-49	proopiomelanocortin	Homo sapiens	114-118
31296192-9	2019	Serum folate was negatively correlated with hs-CRP, TNF-alpha, and IL-6 (P &lt; 0.05).	Folic Acid	6-12	tumor necrosis factor	Homo sapiens	52-61
30993889-1	2019	AIM: The aims of this study were to: (a) measure the proportion of CARTaGENE rheumatoid arthritis (RA) patients fulfilling pre-specified quality indicators (ie disease-modifying antirheumatic drug [DMARD] use, regular follow up, use of folate supplementation, use of vitamin D and calcium, exercise and smoking status); and (b) examine variation in DMARD use with respect to patient age, sex, education and income.	Folic Acid	236-242	CART prepropeptide	Homo sapiens	67-76
31087489-0	2019	Folic acid deficiency enhanced microglial immune response via the Notch1/nuclear factor kappa B p65 pathway in hippocampus following rat brain I/R injury and BV2 cells.	Folic Acid	0-10	synaptotagmin 1	Rattus norvegicus	96-99
31171577-8	2019	Strikingly, the anterior cleft palate in Cbfb mutants is further rescued by pharmaceutical application of folic acid, which activates suppressed Stat3 phosphorylation and Tgfb3 expression in vitro With these findings, we provide the first evidence that Cbfb is a prerequisite for anterior palatogenesis and acts as an obligatory cofactor in the Runx1/Cbfb-Stat3-Tgfb3 signaling axis.	Folic Acid	106-116	signal transducer and activator of transcription 3	Mus musculus	145-150
31171577-8	2019	Strikingly, the anterior cleft palate in Cbfb mutants is further rescued by pharmaceutical application of folic acid, which activates suppressed Stat3 phosphorylation and Tgfb3 expression in vitro With these findings, we provide the first evidence that Cbfb is a prerequisite for anterior palatogenesis and acts as an obligatory cofactor in the Runx1/Cbfb-Stat3-Tgfb3 signaling axis.	Folic Acid	106-116	signal transducer and activator of transcription 3	Mus musculus	356-361
31171577-9	2019	Furthermore, the rescue of the mutant cleft palate using folic acid might highlight potential therapeutic targets aimed at Stat3 modification for the prevention and pharmaceutical intervention of cleft palate.	Folic Acid	57-67	signal transducer and activator of transcription 3	Mus musculus	123-128
31308875-15	2019	Folic acid treatment of diabetic rats induced a reduced glucose level and reduced CAT, SOD, and MDH activities and alleviated the decrease in cardiomyocyte diameters.	Folic Acid	0-10	catalase	Rattus norvegicus	82-85
31200713-2	2019	The aim of this study is to explore the effects of folate pathway gene polymorphisms (the 5-10-methylenetetrahydrofolate reductase, MTHTR C677T, MTHFR A1298C and the methionine synthase reductase, MTRR A66G) and their interactions with homocysteine on serum lipid levels in patients with RSA.	Folic Acid	51-57	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	166-195
31200713-2	2019	The aim of this study is to explore the effects of folate pathway gene polymorphisms (the 5-10-methylenetetrahydrofolate reductase, MTHTR C677T, MTHFR A1298C and the methionine synthase reductase, MTRR A66G) and their interactions with homocysteine on serum lipid levels in patients with RSA.	Folic Acid	51-57	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	197-201
30935429-7	2019	However, there were statistically significant interactions on both multiplicative and additive scale between serum folate and C-reactive protein (CRP) levels or smoking status and the associations of lower serum folate with worse LCSS and OS were only evident among patients with CRP &amp;gt; 3 0 mg/l or current smokers.	Folic Acid	212-218	C-reactive protein	Homo sapiens	146-149
30935429-7	2019	However, there were statistically significant interactions on both multiplicative and additive scale between serum folate and C-reactive protein (CRP) levels or smoking status and the associations of lower serum folate with worse LCSS and OS were only evident among patients with CRP &amp;gt; 3 0 mg/l or current smokers.	Folic Acid	212-218	C-reactive protein	Homo sapiens	280-283
31494266-7	2019	Moreover, significant genetic diversity in MTHFR, TCN2, FADS1, and FADS2, which associate with circulating folate, vitamin B12, or lipid metabolism, was observed between northerners and southerners.	Folic Acid	107-113	fatty acid desaturase 2	Homo sapiens	67-72
31133746-0	2019	MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation.	Folic Acid	35-41	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	0-6
31133746-0	2019	MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation.	Folic Acid	35-41	bromodomain containing 4	Homo sapiens	24-28
31205715-8	2019	As previously described in mice, high doses of folic acid can induce a "pseudo MTHFR" syndrome in wild-type patients, leading to an elevated unmetabolized folic acid syndrome which results in increased serum levels of homocysteine.	Folic Acid	47-57	methylenetetrahydrofolate reductase	Mus musculus	79-84
30288696-3	2019	Low folate intake and genetic variants in folate metabolism, such as the methylenetetrahydrofolate reductase (MTHFR) 677 C&gt;T polymorphism, have been suggested to impact brain function and increase the risk for cognitive decline and late-onset Alzheimer"s disease.	Folic Acid	4-10	methylenetetrahydrofolate reductase	Mus musculus	73-108
30288696-3	2019	Low folate intake and genetic variants in folate metabolism, such as the methylenetetrahydrofolate reductase (MTHFR) 677 C&gt;T polymorphism, have been suggested to impact brain function and increase the risk for cognitive decline and late-onset Alzheimer"s disease.	Folic Acid	4-10	methylenetetrahydrofolate reductase	Mus musculus	110-115
30288696-3	2019	Low folate intake and genetic variants in folate metabolism, such as the methylenetetrahydrofolate reductase (MTHFR) 677 C&gt;T polymorphism, have been suggested to impact brain function and increase the risk for cognitive decline and late-onset Alzheimer"s disease.	Folic Acid	42-48	methylenetetrahydrofolate reductase	Mus musculus	73-108
30288696-3	2019	Low folate intake and genetic variants in folate metabolism, such as the methylenetetrahydrofolate reductase (MTHFR) 677 C&gt;T polymorphism, have been suggested to impact brain function and increase the risk for cognitive decline and late-onset Alzheimer"s disease.	Folic Acid	42-48	methylenetetrahydrofolate reductase	Mus musculus	110-115
31205715-8	2019	As previously described in mice, high doses of folic acid can induce a "pseudo MTHFR" syndrome in wild-type patients, leading to an elevated unmetabolized folic acid syndrome which results in increased serum levels of homocysteine.	Folic Acid	155-165	methylenetetrahydrofolate reductase	Mus musculus	79-84
31060905-0	2019	Disrupted folate metabolism with anesthesia leads to myelination deficits mediated by epigenetic regulation of ERMN.	Folic Acid	10-16	ermin, ERM-like protein	Mus musculus	111-115
31060905-11	2019	Combined with transcriptome and genome-wide DNA methylation analysis, we identified that ERMN was the primary target of the disrupted folate metabolism.	Folic Acid	134-140	ermin, ERM-like protein	Mus musculus	89-93
29390203-9	2019	However, all of the above and hemodynamic index (RI) of femoral artery were resumed via restoration of DHFR protein expression by folic acid treatment or DHFR transfection.	Folic Acid	130-140	dihydrofolate reductase	Rattus norvegicus	103-107
30940490-0	2019	Effects of folic acid supplementation on C-reactive protein: A systematic review and meta-analysis of randomized controlled trials.	Folic Acid	11-21	C-reactive protein	Homo sapiens	41-59
30520966-8	2019	RESULTS: MHC class I HLA-A association was sex related to both the total white adult type 3 PGA collective (n = 158, P = 0.0065), as well as in PGA patients with autoimmune Hashimoto thyroiditis (n = 91, P = 0.010).	Folic Acid	92-95	major histocompatibility complex, class I, A	Homo sapiens	21-26
30520966-14	2019	CONCLUSION: MHC class I HLA-A association with type 3 PGA is significantly affected by sex.	Folic Acid	54-57	major histocompatibility complex, class I, A	Homo sapiens	24-29
30940490-1	2019	BACKGROUND AND AIM: Given the contradictory results of previous randomized controlled trials (RCTs), we performed a systematic review and meta-analysis to quantify and summarize the effects of folic acid supplementation on C-reactive protein (CRP).	Folic Acid	193-203	C-reactive protein	Homo sapiens	223-241
30940490-1	2019	BACKGROUND AND AIM: Given the contradictory results of previous randomized controlled trials (RCTs), we performed a systematic review and meta-analysis to quantify and summarize the effects of folic acid supplementation on C-reactive protein (CRP).	Folic Acid	193-203	C-reactive protein	Homo sapiens	243-246
30940490-3	2019	RCTs that investigated the effect of folate on CRP were included in the present study.	Folic Acid	37-43	C-reactive protein	Homo sapiens	47-50
30940490-7	2019	Pooled analysis results showed that folate supplementation significantly lowered the serum CRP level (weighted mean difference (WMD): -0.685 mg/l, 95% CI: -1.053, -0.318, p &lt; 0.001).	Folic Acid	36-42	C-reactive protein	Homo sapiens	91-94
30940490-11	2019	CONCLUSION: This meta-analysis suggested that folic acid supplementation could significantly lower the serum CRP level.	Folic Acid	46-56	C-reactive protein	Homo sapiens	109-112
30940490-12	2019	Folic acid leads to greater CRP lowering effect in women, patients with T2DM, and those with less than 12-week intervention.	Folic Acid	0-10	C-reactive protein	Homo sapiens	28-31
30708020-5	2019	The surface passivated carrier (PEG-pDNA-TNF-alpha-CS-CGO) then festooned with the folic acid derived carbon dots (C-dots) for targeting folate receptors that are overexpressed in most of the cancer cells.	Folic Acid	83-93	tumor necrosis factor	Homo sapiens	41-50
30993472-6	2019	In addition, the cytotoxic activity of the ternary complex was reduced by the addition of folic acid, a competitor against FR-alpha.	Folic Acid	90-100	rabaptin, RAB GTPase binding effector protein 2	Mus musculus	123-131
30949668-0	2019	Effect of folate supplementation on insulin sensitivity and type 2 diabetes: a meta-analysis of randomized controlled trials.	Folic Acid	10-16	insulin	Homo sapiens	36-43
30794800-1	2019	ALDH1L1 (cytosolic 10-formyltetrahydrofolate dehydrogenase) is the enzyme in folate metabolism commonly downregulated in human cancers.	Folic Acid	38-44	aldehyde dehydrogenase 1 family member L1	Homo sapiens	0-7
30649890-10	2019	In contrast, using the folate nephropathy model, we found reduced fibrosis and improved renal function in both Ltc4s-/- and Lta4h-/- mice.	Folic Acid	23-29	leukotriene A4 hydrolase	Mus musculus	124-129
30476008-5	2019	In the placenta, mTOR responds to a large number of growth-related signals, including amino acids, glucose, oxygen, folate, and growth factors, to regulate trophoblast mitochondrial respiration, nutrient transport, and protein synthesis, thereby influencing fetal growth.	Folic Acid	116-122	mechanistic target of rapamycin kinase	Homo sapiens	17-21
30794800-4	2019	In agreement with the ALDH1L1 loss in cancer, its re-expression leads to inhibition of proliferation and to apoptosis, but also affects migration and invasion of cancer cells through a specific folate-dependent mechanism involved in invasive phenotype.	Folic Acid	194-200	aldehyde dehydrogenase 1 family member L1	Homo sapiens	22-29
30592646-0	2019	The effect of folic acid deficiency on FGF pathway via Brachyury regulation in neural tube defects.	Folic Acid	14-24	brachyury, T-box transcription factor T	Mus musculus	55-64
30941303-5	2019	We aim to develop a CAR-T adaptor molecule (CAM)-based therapy that uses a bispecific small-molecule ligand EC17, fluorescein isothiocyanate (FITC) conjugated with folic acid, to redirect FITC-specific CAR-T cells against folate receptor (FR)-positive tumors.	Folic Acid	164-174	calmodulin 3	Homo sapiens	20-42
30658954-8	2019	Importantly, our results indicated a significant association between ApoE promoter methylation and ACI (OR = 16.146; 95% CI, 1.154-225.832; P* &lt; .05; P*: adjusted for age, gender, carotid atherosclerotic plaque, hypertension, HDL-C, homocysteine, and folate) (Table 4).	Folic Acid	254-260	apolipoprotein E	Homo sapiens	69-73
30920123-0	2019	DNA Hypomethylation of GR Promoters is Associated with GR Activation and BDNF/AKT/ERK1/2-Induced Hippocampal Neurogenesis in Mice Derived From Folic-Acid-Supplemented Dams.	Folic Acid	143-153	nuclear receptor subfamily 3, group C, member 1	Mus musculus	23-25
30920123-0	2019	DNA Hypomethylation of GR Promoters is Associated with GR Activation and BDNF/AKT/ERK1/2-Induced Hippocampal Neurogenesis in Mice Derived From Folic-Acid-Supplemented Dams.	Folic Acid	143-153	thymoma viral proto-oncogene 1	Mus musculus	78-81
30920123-6	2019	More GR immune-positive cells are observed in hippocampus of folic acid group, which are in line with higher GR protein and mRNA abundances.	Folic Acid	61-71	nuclear receptor subfamily 3, group C, member 1	Mus musculus	5-7
30920123-6	2019	More GR immune-positive cells are observed in hippocampus of folic acid group, which are in line with higher GR protein and mRNA abundances.	Folic Acid	61-71	nuclear receptor subfamily 3, group C, member 1	Mus musculus	109-111
30893314-10	2019	FTCD is critical for catabolism of histidine, a process that generates one-carbon units that can enter the one-carbon/folate cycle, which provides methyl groups for arsenic metabolism.	Folic Acid	118-124	formimidoyltransferase cyclodeaminase	Homo sapiens	0-4
30893314-12	2019	In summary, this work identifies a coding variant in FTCD associated with arsenic metabolism efficiency, providing new evidence supporting the established link between one-carbon/folate metabolism and arsenic toxicity.	Folic Acid	179-185	formimidoyltransferase cyclodeaminase	Homo sapiens	53-57
30941303-5	2019	We aim to develop a CAR-T adaptor molecule (CAM)-based therapy that uses a bispecific small-molecule ligand EC17, fluorescein isothiocyanate (FITC) conjugated with folic acid, to redirect FITC-specific CAR-T cells against folate receptor (FR)-positive tumors.	Folic Acid	164-174	calmodulin 3	Homo sapiens	44-47
30886396-4	2019	Although both Mtb infection and exogenously added antigens are presented by preformed MR1, only exogenously added antigens are capable of reusing MR1 that had been bound to the folic acid metabolite 6-formylpterin (6-FP).	Folic Acid	177-187	major histocompatibility complex, class I-related	Homo sapiens	146-149
30844704-3	2019	GCPII has been recognized as a neuropeptidase in the central nervous system, as a folate hydrolase participating in absorption of folates in the jejunum and, most importantly, as a prostate-specific membrane antigen that is highly expressed in prostate adenocarcinoma.	Folic Acid	130-137	folate hydrolase 1	Homo sapiens	0-5
30881086-2	2019	Several studies suggest that the decrease in folate has been associated with a higher risk of NSCL/P.	Folic Acid	45-51	nescient helix-loop-helix 1	Homo sapiens	94-98
30848279-2	2019	A key pathway of this metabolism is the vitamin B-12- and folate-dependent remethylation of homocysteine, which depends on methionine synthase (MS, encoded by MTR), methionine synthase reductase, and methylenetetrahydrofolate reductase.	Folic Acid	58-64	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	165-194
30828450-10	2019	Moreover, use of vitamin B12 supplements involved an improvement of vitamin B12 status but further increase in erythrocyte folate (P = 0 024).	Folic Acid	123-129	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	25-28
30781902-8	2019	Maternal vitamin B12 concentrations (p &lt; 0.001) and vitamin B12 deficiency (p = 0.002) at delivery were significantly associated with infant vitamin B12 concentrations in multivariate analyses, adjusting for gestational age, maternal age, parity, smoking status, relationship status, prenatal supplement use, pre-pregnancy body mass index, race, and intake of vitamin B12 and folate.	Folic Acid	379-385	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	17-20
30447272-8	2019	Moreover, maternal folic acid deficiency downregulated Bcl-2 and upregulated Bax, and this effect associate with maternal folic acid deficient increases expression of microRNA-34a.	Folic Acid	19-29	BCL2, apoptosis regulator	Rattus norvegicus	55-60
30670450-3	2019	A Rho-kinase deficient binding mutant of the apical constriction regulating protein, Shroom3 (Shroom3R1838C), is one of only a handful of mouse mutant lines with neural tube defects that can be rescued by folic acid supplementation.	Folic Acid	205-215	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	2-12
30670450-5	2019	Utilizing an epithelial cell culture model of apical constriction, it was observed that treatment with exogenous folic acid, as well as co-expression of the folic acid receptor Folr1, can rescue the function of the Rho-kinase binding deficient mutant of Shroom3 in vitro It was also determined that the rescuing ability of folic acid is RhoA and Rho-kinase independent but myosin light chain kinase (MLCK) and Src-kinase dependent.	Folic Acid	113-123	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	215-225
30670450-5	2019	Utilizing an epithelial cell culture model of apical constriction, it was observed that treatment with exogenous folic acid, as well as co-expression of the folic acid receptor Folr1, can rescue the function of the Rho-kinase binding deficient mutant of Shroom3 in vitro It was also determined that the rescuing ability of folic acid is RhoA and Rho-kinase independent but myosin light chain kinase (MLCK) and Src-kinase dependent.	Folic Acid	113-123	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	346-356
30670450-5	2019	Utilizing an epithelial cell culture model of apical constriction, it was observed that treatment with exogenous folic acid, as well as co-expression of the folic acid receptor Folr1, can rescue the function of the Rho-kinase binding deficient mutant of Shroom3 in vitro It was also determined that the rescuing ability of folic acid is RhoA and Rho-kinase independent but myosin light chain kinase (MLCK) and Src-kinase dependent.	Folic Acid	157-167	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	215-225
30670450-5	2019	Utilizing an epithelial cell culture model of apical constriction, it was observed that treatment with exogenous folic acid, as well as co-expression of the folic acid receptor Folr1, can rescue the function of the Rho-kinase binding deficient mutant of Shroom3 in vitro It was also determined that the rescuing ability of folic acid is RhoA and Rho-kinase independent but myosin light chain kinase (MLCK) and Src-kinase dependent.	Folic Acid	157-167	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	346-356
30670450-6	2019	Inhibition of Rho-kinase-dependent apical constriction in chick embryo neural epithelium was also observed to be rescued by exogenous folic acid and that treatment with folic acid is accompanied by elevated activated myosin light chain and MLCK.	Folic Acid	134-144	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	14-24
30670450-6	2019	Inhibition of Rho-kinase-dependent apical constriction in chick embryo neural epithelium was also observed to be rescued by exogenous folic acid and that treatment with folic acid is accompanied by elevated activated myosin light chain and MLCK.	Folic Acid	169-179	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	14-24
30670450-6	2019	Inhibition of Rho-kinase-dependent apical constriction in chick embryo neural epithelium was also observed to be rescued by exogenous folic acid and that treatment with folic acid is accompanied by elevated activated myosin light chain and MLCK.	Folic Acid	169-179	myosin light chain kinase	Gallus gallus	240-244
30615110-0	2019	Effect of folate supplementation on insulin sensitivity and type 2 diabetes: a meta-analysis of randomized controlled trials.	Folic Acid	10-16	insulin	Homo sapiens	36-43
30615110-8	2019	Results: When compared with placebo, folate supplementation lowered fasting insulin (WMD: -13.47 pmol/L; 95% CI: -21.41, -5.53 pmol/L; P < 0.001) and HOMA-IR (WMD: -0.57 units; 95% CI: -0.76, -0.37 units; P < 0.0001), but no overall effects were observed for fasting glucose or HbA1c.	Folic Acid	37-43	insulin	Homo sapiens	76-83
30183434-1	2019	OBJECTIVES: Methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) plays an essential role in folate-mediated one-carbon metabolism which determines both homocysteine remethylation and de novo thymidylate biosynthesis.	Folic Acid	31-37	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	55-61
29255930-10	2019	CONCLUSION: Folic acid supplementation appears to improve cognitive function and reduce blood levels of Abeta-related biomarkers in MCI.	Folic Acid	12-22	amyloid beta precursor protein	Homo sapiens	104-109
30447272-3	2019	We hypothesized that aberrant neuronal apoptosis may affect the development of the central nervous system during maternal folic acid deficiency, with evident effects because maternal folic acid deficiency modulates the microRNA-34a associated with Bcl-2 pathway during embryonic development.	Folic Acid	183-193	BCL2, apoptosis regulator	Rattus norvegicus	248-253
31345146-10	2019	RESULTS: Compared with control group, the folic acid plus vitamin B 12 group had significantly greater improvements in serum folate, homocysteine, vitamin B 12 and IL-6, TNF-alpha, MCP-1.	Folic Acid	42-52	interleukin 6	Homo sapiens	164-168
31345146-10	2019	RESULTS: Compared with control group, the folic acid plus vitamin B 12 group had significantly greater improvements in serum folate, homocysteine, vitamin B 12 and IL-6, TNF-alpha, MCP-1.	Folic Acid	42-52	tumor necrosis factor	Homo sapiens	170-179
31801452-3	2019	Glutathione deficiency decreases the mitochondrial protection against oxidants and tumor necrosis factor (TNF)-alpha; immune dysregulation and inflammation inhibit mitochondrial function through TNF-alpha; autoantibodies against the folate receptors underpin cerebral folate deficiency, resulting in disturbed methylation, and mitochondrial dysfunction.	Folic Acid	233-239	tumor necrosis factor	Homo sapiens	195-204
30480514-0	2019	Folate-Modified Liposomes Loaded with Telmisartan Enhance Anti-Atherosclerotic Potency for Advanced Atherosclerosis in ApoE-/- Mice.	Folic Acid	0-6	apolipoprotein E	Mus musculus	119-123
31099011-4	2019	Flow cytometry displayed that AuNPs-PEI-FA could specifically deliver siRNA into LNCaP cells, a prostate cancer cell line overexpressing prostate-specific membrane antigen (PSMA) that exhibits a hydrolase enzymatic activity with a folate substrate.	Folic Acid	231-237	folate hydrolase 1	Homo sapiens	137-171
31099011-4	2019	Flow cytometry displayed that AuNPs-PEI-FA could specifically deliver siRNA into LNCaP cells, a prostate cancer cell line overexpressing prostate-specific membrane antigen (PSMA) that exhibits a hydrolase enzymatic activity with a folate substrate.	Folic Acid	231-237	folate hydrolase 1	Homo sapiens	173-177
30447272-8	2019	Moreover, maternal folic acid deficiency downregulated Bcl-2 and upregulated Bax, and this effect associate with maternal folic acid deficient increases expression of microRNA-34a.	Folic Acid	122-132	BCL2, apoptosis regulator	Rattus norvegicus	55-60
30447272-9	2019	Together, the present results indicate that maternal folic acid deficiency stimulates neuronal apoptosis via microRNA-34a associated with Bcl-2 signalling in rat offspring.	Folic Acid	53-63	BCL2, apoptosis regulator	Rattus norvegicus	138-143
30521542-12	2018	RESULTS: After adjusting for potential confounders in logistic regression models, the OR for pre-eclampsia was 0.80 (95% CI: 0.72, 0.90) for 1SD increase in log-folate, 1.16 (95%CI: 1.05, 1.27) for 1SD increase in log-homocysteine, and 1.10 (95%CI: 0.99, 1.22) for 1SD increase in log-vitamin B12.	Folic Acid	161-167	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	293-296
30155754-10	2018	Fc-folate binds with high affinity to FRA compared to whole IgA-folate and induces MPO release from PMN when bound to FcalphaR1.	Folic Acid	3-9	myeloperoxidase	Homo sapiens	83-86
30372582-6	2018	RESULTS: During the follow-up, change in folate was significantly and independently correlated with change in ba-PWV in study patients (beta = -1.31, P &lt; 0.001).	Folic Acid	41-47	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	136-145
30565175-0	2018	Synergistic delivery of 5-fluorouracil and curcumin using human serum albumin-coated iron oxide nanoparticles by folic acid targeting.	Folic Acid	113-123	albumin	Homo sapiens	70-77
30565175-4	2018	Furthermore, folic acid was decorated on human serum albumin by EDC and NHS coupling to confer targetability.	Folic Acid	13-23	albumin	Homo sapiens	53-60
30076902-5	2018	Interestingly, the repressor activity of FOXD3 is completely abolished by treating Caski cells with folate via a mechanism that involves methylation of FOXD3 gene promoter.	Folic Acid	100-106	forkhead box D3	Homo sapiens	41-46
30076902-5	2018	Interestingly, the repressor activity of FOXD3 is completely abolished by treating Caski cells with folate via a mechanism that involves methylation of FOXD3 gene promoter.	Folic Acid	100-106	forkhead box D3	Homo sapiens	152-157
30055159-2	2018	Metheylenetetrahydrofolate reductase (MTHFR) is an enzyme involved in the metabolism of folic acid, a B-vitamin.	Folic Acid	88-98	methylenetetrahydrofolate reductase	Mus musculus	0-36
30055159-2	2018	Metheylenetetrahydrofolate reductase (MTHFR) is an enzyme involved in the metabolism of folic acid, a B-vitamin.	Folic Acid	88-98	methylenetetrahydrofolate reductase	Mus musculus	38-43
30160343-4	2018	To establish a safe and effective AIM2 gene delivery system, we formed the nanoparticles consisting of a folate grafted PEI600-CyD (H1) nanoparticle-mediated AIM2 gene (H1/pAIM2) as an effective delivery agent.	Folic Acid	105-111	absent in melanoma 2	Homo sapiens	34-38
29542054-0	2018	Folic Acid Exerts Post-Ischemic Neuroprotection In Vitro Through HIF-1alpha Stabilization.	Folic Acid	0-10	hypoxia inducible factor 1 alpha subunit	Gallus gallus	65-75
30415553-7	2018	Additionally, folic acid intake resulted in a significant reduction in serum high sensitivity C-reactive protein (hs-CRP) (beta -0.36 mg/L; 95% CI, -0.52, -0.21; P &lt; 0.001) compared with the placebo.	Folic Acid	14-24	C-reactive protein	Homo sapiens	94-112
30178194-10	2018	Inhibition of NRF-1 mediated folate transporter expression significantly reduced intracellular folate levels.	Folic Acid	29-35	nuclear respiratory factor 1	Mus musculus	14-19
30178194-10	2018	Inhibition of NRF-1 mediated folate transporter expression significantly reduced intracellular folate levels.	Folic Acid	95-101	nuclear respiratory factor 1	Mus musculus	14-19
30178194-11	2018	These results suggest that chronic consumption of high-fat diets impairs folate transporter expression via NRF-1-dependent mechanism, leading to reduced hepatic folate storage.	Folic Acid	73-79	nuclear respiratory factor 1	Mus musculus	107-112
30178194-11	2018	These results suggest that chronic consumption of high-fat diets impairs folate transporter expression via NRF-1-dependent mechanism, leading to reduced hepatic folate storage.	Folic Acid	161-167	nuclear respiratory factor 1	Mus musculus	107-112
30178194-15	2018	NRF-1 regulates hepatic folate transporters expression and folate levels.	Folic Acid	24-30	nuclear respiratory factor 1	Mus musculus	0-5
30178194-15	2018	NRF-1 regulates hepatic folate transporters expression and folate levels.	Folic Acid	59-65	nuclear respiratory factor 1	Mus musculus	0-5
30192066-9	2018	In a nested cohort of cord blood samples (n = 148), SH3GL3 methylation is inversely related to maternal RBC folate concentrations (p = 0.008).	Folic Acid	108-114	SH3 domain containing GRB2 like 3, endophilin A3	Homo sapiens	52-58
30150380-4	2018	We observed that sperm from LPD-fed male mice displayed global hypomethylation associated with reduced testicular expression of DNA methylation and folate-cycle regulators compared with normal protein diet (NPD) fed males.	Folic Acid	148-154	acyl-CoA synthetase bubblegum family member 1	Mus musculus	28-31
29885392-0	2018	Folic acid conjugated bovine serum albumin: An efficient smart and tumor targeted biomacromolecule for inhibition folate receptor positive cancer cells.	Folic Acid	0-10	albumin	Homo sapiens	29-42
28705466-8	2018	According to the multivariate ordinal regression analysis, serum folic acid levels were inversely correlated with liver steatosis grades (OR 0.739 [0.594-0.918], P = 0.006) independent of age, gender, BMI, components of metabolic syndrome and the serum TC, LDL-c and HOMA-IR levels.	Folic Acid	65-75	component of oligomeric golgi complex 2	Homo sapiens	257-262
28780990-0	2018	Folate and vitamin B12 status is associated with insulin resistance and metabolic syndrome in morbid obesity.	Folic Acid	0-6	insulin	Homo sapiens	49-56
28780990-1	2018	BACKGROUND: Low vitamin B12 and high folate during pregnancy are associated with visceral obesity and insulin resistance in offspring.	Folic Acid	37-43	insulin	Homo sapiens	102-109
29885392-1	2018	This work described a folic acid conjugated delivery of chrysin-loaded bovine serum albumin nanoparticles, which could overcome the nonspecific targeting disadvantage.	Folic Acid	22-32	albumin	Homo sapiens	78-91
30338724-0	2018	Targeted folate-conjugated pluronic P85/poly(lactide-co-glycolide) polymersome for the oral delivery of insulin.	Folic Acid	9-15	insulin	Homo sapiens	104-111
30041718-3	2018	Herein, a folate-decorated PCL-ss-PEG-ss-PCL based redox-responsive polymersome (FA-TQR-Co-PS) was constructed, which was loaded with P-gp inhibitor tariquidar (TQR), anticancer drugs doxorubicin (DOX) and paclitaxel (PTX).	Folic Acid	10-16	ATP binding cassette subfamily B member 1	Homo sapiens	134-138
30056106-0	2018	Improvement of symptoms in a rat model of depression through combined zinc and folic acid administration via up-regulation of the Trk B and NMDA.	Folic Acid	79-89	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	130-135
30125807-0	2018	Folic acid modulates VPO1 DNA methylation levels and alleviates oxidative stress-induced apoptosis in vivo and in vitro.	Folic Acid	0-10	peroxidasin	Homo sapiens	21-25
30125807-4	2018	We aimed to investigate the effects of folic acid on injuries induced by oxidative stress that occur via an epigenetic gene silencing mechanism in ApoE knockout mice fed a high-fat diet and in human umbilical vein endothelial cells treated with oxidized low-density lipoprotein (ox-LDL).	Folic Acid	39-49	apolipoprotein E	Mus musculus	147-151
30125807-7	2018	Our data showed that folic acid reduced 8-OHdG levels and decreased apoptosis in the aortic tissue of ApoE-/- mice.	Folic Acid	21-31	apolipoprotein E	Mus musculus	102-106
30125807-10	2018	Collectively, we conclude that folic acid supplementation may prevent oxidative stress-induced apoptosis and suppresses ROS levels through downregulating VPO1 as a consequence of changes in DNA methylation, which may contribute to beneficial effects on endothelial function.	Folic Acid	31-41	peroxidasin	Homo sapiens	154-158
30071349-10	2018	In the tumor gene therapy with a small hairpin RNA silencing vascular endothelial growth factor, FA-e-polyplexes afforded higher tumor growth inhibition than polyplexes of folate-PEGylated PUBAP and 25 kDa linear polyethylenimine as positive controls.	Folic Acid	172-178	vascular endothelial growth factor A	Homo sapiens	61-95
29656957-7	2018	PGA alone was sufficient to induce expression of TNF-alpha, IL-6, MCP-1, and MIP1-alpha, whereas MDP alone did not under the same conditions.	Folic Acid	0-3	tumor necrosis factor	Mus musculus	49-58
29656957-7	2018	PGA alone was sufficient to induce expression of TNF-alpha, IL-6, MCP-1, and MIP1-alpha, whereas MDP alone did not under the same conditions.	Folic Acid	0-3	interleukin 6	Mus musculus	60-64
29656957-7	2018	PGA alone was sufficient to induce expression of TNF-alpha, IL-6, MCP-1, and MIP1-alpha, whereas MDP alone did not under the same conditions.	Folic Acid	0-3	mast cell protease 1	Mus musculus	66-71
30056106-10	2018	We conclude that combined administration of zinc and folic acid can improve the symptoms of depression-model rats, and its mechanism is related to increased levels of 5-HT, DA and NE in the brain, and to the up-regulation of Trk B and NMDA.	Folic Acid	53-63	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	225-230
29976587-5	2018	RESULTS: Reduced phosphorylation of ACC on the AMPK site Ser79 occurred in both tubular epithelial cells treated with folate to mimic cellular injury and in wild-type (WT) mice after induction of the folic acid nephropathy model.	Folic Acid	118-124	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	47-51
30213067-10	2018	Moreover, folic acid decreased the mRNA expression of TEAD1 and the protein expression of TEAD1 and YAP1.	Folic Acid	10-20	TEA domain transcription factor 1	Homo sapiens	54-59
30213067-10	2018	Moreover, folic acid decreased the mRNA expression of TEAD1 and the protein expression of TEAD1 and YAP1.	Folic Acid	10-20	TEA domain transcription factor 1	Homo sapiens	90-95
30198899-1	2018	A high-pressure crystallographic study was conducted on Escherichia coli dihydrofolate reductase (ecDHFR) complexed with folate and NADP+ in crystal forms containing both the open and closed conformations of the M20 loop under high-pressure conditions of up to 800 MPa.	Folic Acid	80-86	dihydrofolate reductase	Escherichia coli	98-104
29913560-0	2018	Maternal folic acid supplementation with vitamin B12 deficiency during pregnancy and lactation affects the metabolic health of adult female offspring but is dependent on offspring diet.	Folic Acid	9-19	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	49-52
29913560-1	2018	Epidemiologic studies have reported relationships between maternal high folate and/or low B12 status during pregnancy and greater adiposity and insulin resistance in children.	Folic Acid	72-78	insulin	Homo sapiens	144-151
29976587-5	2018	RESULTS: Reduced phosphorylation of ACC on the AMPK site Ser79 occurred in both tubular epithelial cells treated with folate to mimic cellular injury and in wild-type (WT) mice after induction of the folic acid nephropathy model.	Folic Acid	200-210	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	47-51
29380373-10	2018	Folic acid induced nephropathy was associated with the overexpression of inflammatory markers MCP-1, F4/80, type IV collagen, fibronectin and TGF-beta1 compared to control groups, which were partially attenuated by metformin treatment.	Folic Acid	0-10	mast cell protease 1	Mus musculus	94-99
29717938-7	2018	To overcome this problem, we previously demonstrated that folate-conjugated rapamycin (FC-rapa) targets polycystic kidneys due to the high expression of the folate receptor (FRalpha) and that treatment of a nonortholgous PKD mouse model leads to inhibition of renal cyst growth.	Folic Acid	58-64	rabaptin, RAB GTPase binding effector protein 2	Mus musculus	174-181
30120883-3	2018	This study aims to evaluate the association between genetic defects in folate metabolism pathway genes, mainly: Folate hydrolase 1 (FOLH1), Dihydrofolate reductase (DHFR) and Methylenetetrahydrofolate reductase (MTHFR) and neural tube defects from eastern India.	Folic Acid	71-77	folate hydrolase 1	Homo sapiens	112-130
30120883-3	2018	This study aims to evaluate the association between genetic defects in folate metabolism pathway genes, mainly: Folate hydrolase 1 (FOLH1), Dihydrofolate reductase (DHFR) and Methylenetetrahydrofolate reductase (MTHFR) and neural tube defects from eastern India.	Folic Acid	71-77	folate hydrolase 1	Homo sapiens	132-137
29783176-9	2018	NAC, folic acid and omega-3 increased superoxide dismutase and catalase activities in the rat brain subjected to early or late life stress.	Folic Acid	5-15	catalase	Rattus norvegicus	63-71
30116142-3	2018	The aim of this study was to evaluate the effects of folic acid, choline, vitamin B12, and a combination of all on preventing the lipopolysaccharide- (LPS-) induced inflammatory response in human THP-1 monocyte/macrophage cells.	Folic Acid	53-63	GLI family zinc finger 2	Homo sapiens	196-201
29861060-2	2018	Mice with folic acid-induced AKI had an increase in bone FGF23 mRNA expression together with an increase in serum FGF23 and several circulating cytokines including interleukin-6 (IL-6).	Folic Acid	10-20	interleukin 6	Mus musculus	164-177
29861060-2	2018	Mice with folic acid-induced AKI had an increase in bone FGF23 mRNA expression together with an increase in serum FGF23 and several circulating cytokines including interleukin-6 (IL-6).	Folic Acid	10-20	interleukin 6	Mus musculus	179-183
29732722-10	2018	Eight more candidate genes (Abcc3, Gsr, Gclc, Mthfd1, Gart, Bche, Slc25a32, and Slc44a2) were identified by examining the DEGs of those genes involved in the extended folate metabolic pathway between FA-responsive and FA-resistant mutants.	Folic Acid	167-173	butyrylcholinesterase	Mus musculus	60-64
29732722-10	2018	Eight more candidate genes (Abcc3, Gsr, Gclc, Mthfd1, Gart, Bche, Slc25a32, and Slc44a2) were identified by examining the DEGs of those genes involved in the extended folate metabolic pathway between FA-responsive and FA-resistant mutants.	Folic Acid	167-173	solute carrier family 25, member 32	Mus musculus	66-74
30087941-0	2018	Drug-Carrying Capacity and Anticancer Effect of the Folic Acid- and Berberine-Loaded Silver Nanomaterial To Regulate the AKT-ERK Pathway in Breast Cancer.	Folic Acid	52-62	AKT serine/threonine kinase 1	Homo sapiens	121-124
30087941-0	2018	Drug-Carrying Capacity and Anticancer Effect of the Folic Acid- and Berberine-Loaded Silver Nanomaterial To Regulate the AKT-ERK Pathway in Breast Cancer.	Folic Acid	52-62	mitogen-activated protein kinase 1	Homo sapiens	125-128
30116142-4	2018	Folic acid and the mixture of methyl donors reduced interleukin 1 beta (IL1B) and tumour necrosis factor (TNF) expression as well as protein secretion by these cells.	Folic Acid	0-10	interleukin 1 beta	Homo sapiens	52-70
30116142-4	2018	Folic acid and the mixture of methyl donors reduced interleukin 1 beta (IL1B) and tumour necrosis factor (TNF) expression as well as protein secretion by these cells.	Folic Acid	0-10	interleukin 1 beta	Homo sapiens	72-76
30116142-4	2018	Folic acid and the mixture of methyl donors reduced interleukin 1 beta (IL1B) and tumour necrosis factor (TNF) expression as well as protein secretion by these cells.	Folic Acid	0-10	tumor necrosis factor	Homo sapiens	82-104
30116142-4	2018	Folic acid and the mixture of methyl donors reduced interleukin 1 beta (IL1B) and tumour necrosis factor (TNF) expression as well as protein secretion by these cells.	Folic Acid	0-10	tumor necrosis factor	Homo sapiens	106-109
29936926-1	2018	Mandatory fortification of staple grains with folic acid and/or vitamin B12 (B12) is under debate in many countries including Ireland, which has a liberal, but voluntary, fortification policy.	Folic Acid	46-56	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	77-80
29250709-6	2018	We showed that folic acid increased cell viability and decreased apoptosis in a dose-dependent manner, and that this effect was mediated by decreased caspase-3/7 activity, upregulated BCL2/BAX ratio, and downregulated TP53, CASP3, and CASP8 expressions.	Folic Acid	15-25	caspase 3	Homo sapiens	150-159
29250709-6	2018	We showed that folic acid increased cell viability and decreased apoptosis in a dose-dependent manner, and that this effect was mediated by decreased caspase-3/7 activity, upregulated BCL2/BAX ratio, and downregulated TP53, CASP3, and CASP8 expressions.	Folic Acid	15-25	BCL2 apoptosis regulator	Homo sapiens	184-188
29250709-6	2018	We showed that folic acid increased cell viability and decreased apoptosis in a dose-dependent manner, and that this effect was mediated by decreased caspase-3/7 activity, upregulated BCL2/BAX ratio, and downregulated TP53, CASP3, and CASP8 expressions.	Folic Acid	15-25	BCL2 associated X, apoptosis regulator	Homo sapiens	189-192
29250709-6	2018	We showed that folic acid increased cell viability and decreased apoptosis in a dose-dependent manner, and that this effect was mediated by decreased caspase-3/7 activity, upregulated BCL2/BAX ratio, and downregulated TP53, CASP3, and CASP8 expressions.	Folic Acid	15-25	tumor protein p53	Homo sapiens	218-222
29250709-6	2018	We showed that folic acid increased cell viability and decreased apoptosis in a dose-dependent manner, and that this effect was mediated by decreased caspase-3/7 activity, upregulated BCL2/BAX ratio, and downregulated TP53, CASP3, and CASP8 expressions.	Folic Acid	15-25	caspase 3	Homo sapiens	224-229
30038085-13	2018	It may be suggested that maternal decrease in vitamin B12, in mothers who have normal folic acid may be associated with NTD in their children.	Folic Acid	86-96	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	54-57
29551366-4	2018	The absence of Erk2 resulted in a complete loss of folate and cAMP chemotaxis suggesting that this MAPK plays an integral role in the signaling mechanisms involved with this cellular response.	Folic Acid	51-57	mitogen-activated protein kinase 1	Homo sapiens	15-19
29551366-8	2018	Loss of Erk2 impaired the phosphorylation of Erk1 in secondary responses to folate stimulation indicating that Erk2 has a role in the regulation of Erk1 activation during chemotaxis.	Folic Acid	76-82	mitogen-activated protein kinase 1	Homo sapiens	8-12
29551366-8	2018	Loss of Erk2 impaired the phosphorylation of Erk1 in secondary responses to folate stimulation indicating that Erk2 has a role in the regulation of Erk1 activation during chemotaxis.	Folic Acid	76-82	mitogen-activated protein kinase 3	Homo sapiens	45-49
29551366-8	2018	Loss of Erk2 impaired the phosphorylation of Erk1 in secondary responses to folate stimulation indicating that Erk2 has a role in the regulation of Erk1 activation during chemotaxis.	Folic Acid	76-82	mitogen-activated protein kinase 1	Homo sapiens	111-115
29551366-8	2018	Loss of Erk2 impaired the phosphorylation of Erk1 in secondary responses to folate stimulation indicating that Erk2 has a role in the regulation of Erk1 activation during chemotaxis.	Folic Acid	76-82	mitogen-activated protein kinase 3	Homo sapiens	148-152
29551366-9	2018	Loss of the only known Dictyostelium MAPK kinase, MekA, prevented the phosphorylation of Erk1 but not Erk2 in response to folate and cAMP confirming that Erk2 is not regulated by a conventional MAP2K.	Folic Acid	122-128	mitogen-activated protein kinase 3	Homo sapiens	89-93
30116142-0	2018	Folic Acid Improves the Inflammatory Response in LPS-Activated THP-1 Macrophages.	Folic Acid	0-10	GLI family zinc finger 2	Homo sapiens	63-68
29942129-3	2018	The current study aims to achieve better glioma treatment through a combinative therapy based on a folate-targeted nanocarrier carrying both temozolomide (TMZ) and anti-BCL-2 siRNA.	Folic Acid	99-105	BCL2, apoptosis regulator	Rattus norvegicus	169-174
29942129-9	2018	Conclusion: Our results evidence the strong efficacy of the folate-targeted nanomedicine carrying TMZ and BCL-2 siRNA in treating glioma.	Folic Acid	60-66	BCL2, apoptosis regulator	Rattus norvegicus	106-111
28381340-10	2018	CONCLUSIONS: Higher maternal folate coupled with vitamin B12 insufficiency was associated with higher GDM risk.	Folic Acid	29-35	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	57-60
29546377-6	2018	Results: We found an association at cg09112514 (p = 4.03x10-9), a CpG located in the 5" untranslated region of PDGFRA, in the main analysis comparing the intervention arms [low- (0.2 mg) and high-dose (5 mg) folic acid combined (N = 43)] vs placebo (N = 43).	Folic Acid	208-218	platelet derived growth factor receptor alpha	Homo sapiens	111-117
29501221-10	2018	Folate decreased fasting glucose (-0.15 mmol/L, 95% confidence interval [CI] -0.29 to -0.01), homeostatic model assessment-insulin resistance (-0.83, 95% CI -1.31 to -0.34), and insulin (-1.94 muIU/mL, 95% CI -3.28 to -0.61) but had no clear effect on diabetes or HbA1c.	Folic Acid	0-6	insulin	Homo sapiens	123-130
29685624-0	2018	Folic acid supplementation repressed hypoxia-induced inflammatory response via ROS and JAK2/STAT3 pathway in human promyelomonocytic cells.	Folic Acid	0-10	signal transducer and activator of transcription 3	Homo sapiens	92-97
29685624-4	2018	Our results indicated that supplementation with folic acid significantly reduced the levels of interleukin-1beta and tumor necrosis factor-alpha in hypoxic conditions.	Folic Acid	48-58	interleukin 1 beta	Homo sapiens	95-144
29685624-5	2018	Treating THP-1 cells with folic acid suppressed oxidative stress and hypoxia-inducible factor-1alpha in a dose-dependent manner.	Folic Acid	26-36	hypoxia inducible factor 1 subunit alpha	Homo sapiens	69-100
29685624-6	2018	Folic acid targeted the activation of Janus kinase 2, downregulated the phosphorylation of signal transducer and activator of transcription 3, and decreased the expression of nuclear factor-kappaB p65 protein in cells.	Folic Acid	0-10	signal transducer and activator of transcription 3	Homo sapiens	91-141
29685624-8	2018	In conclusion, folic acid efficiently inhibited the inflammatory response of THP-1 cells under hypoxic conditions by inhibiting reactive oxygen species production and the Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway.	Folic Acid	15-25	signal transducer and activator of transcription 3	Homo sapiens	186-236
29581245-1	2018	Several studies have reported an association between levels of folate, homocysteine, and vitamin B12 and the risk of colorectal polyps.	Folic Acid	63-69	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	97-100
29644791-7	2018	The methylation levels of 3 CpG sites (cg15200711, cg19462022, and cg07035602) in LPCAT1 and RASA3 genes are associated with fiber (false discovery rate [FDR] &lt; 0.05) after adjustment for covariates including folic acid.	Folic Acid	212-222	RAS p21 protein activator 3	Homo sapiens	93-98
29680672-0	2018	Targeting of folate-conjugated liposomes with co-entrapped drugs to prostate cancer cells via prostate-specific membrane antigen (PSMA).	Folic Acid	13-19	folate hydrolase 1	Homo sapiens	94-128
29680672-0	2018	Targeting of folate-conjugated liposomes with co-entrapped drugs to prostate cancer cells via prostate-specific membrane antigen (PSMA).	Folic Acid	13-19	folate hydrolase 1	Homo sapiens	130-134
29379142-5	2018	We used weighted logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the relation between quartiles of folate and vitamin B12, and hearing loss (present if PTA &gt; 25 dB in either ear and absent if PTA &lt;= 25 dB in both ears).	Folic Acid	140-146	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	159-162
29666258-4	2018	Herein, we show that gene trap inactivation of Slc25a32 (Mft) in mice induces NTDs that are folate (5-methyltetrahydrofolate, 5-mTHF) resistant yet are preventable by formate supplementation.	Folic Acid	92-98	solute carrier family 25, member 32	Mus musculus	47-55
29760651-2	2018	FMR1 alleles with more than 200 CGG repeats bear chromosomal fragility when cells experience folate deficiency.	Folic Acid	93-99	fragile X messenger ribonucleoprotein 1	Homo sapiens	0-4
29483189-2	2018	Homozygous deletion of the 1C pathway gene Mthfd1l encoding methylenetetrahydrofolate dehydrogenase (NADP+-dependent) 1-like, which catalyzes mitochondrial formate production from 10-formyltetrahydrofolate, results in 100% penetrant embryonic neural tube defects (NTDs), underscoring the central role of mitochondrially derived formate in embryonic development and providing a mechanistic link between folate and NTDs.	Folic Acid	79-85	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like	Mus musculus	43-50
29412638-7	2018	In vitro, all four 5-MTHF conjugates showed similar binding affinities to FR-alpha (IC50 = 17.7-24.0 nM), whereas folic acid showed a significantly higher binding affinity to the FR-alpha.	Folic Acid	114-124	rabaptin, RAB GTPase binding effector protein 2	Mus musculus	179-187
29588419-7	2018	Additionally, folic acid-induced AKI in mice resulted in increased expression of Fn14 and necroptosis mediators, such as receptor-interacting protein kinase 1 (RIPK1), RIPK3, and mixed lineage domain-like protein (MLKL).	Folic Acid	14-24	receptor (TNFRSF)-interacting serine-threonine kinase 1	Mus musculus	121-158
29588419-7	2018	Additionally, folic acid-induced AKI in mice resulted in increased expression of Fn14 and necroptosis mediators, such as receptor-interacting protein kinase 1 (RIPK1), RIPK3, and mixed lineage domain-like protein (MLKL).	Folic Acid	14-24	receptor (TNFRSF)-interacting serine-threonine kinase 1	Mus musculus	160-165
29614799-13	2018	CONCLUSION: Our study demonstrated a statistically significant correlation between low levels of folate and vitamin B12 with the histological severity of NASH.	Folic Acid	97-103	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	116-119
29501221-10	2018	Folate decreased fasting glucose (-0.15 mmol/L, 95% confidence interval [CI] -0.29 to -0.01), homeostatic model assessment-insulin resistance (-0.83, 95% CI -1.31 to -0.34), and insulin (-1.94 muIU/mL, 95% CI -3.28 to -0.61) but had no clear effect on diabetes or HbA1c.	Folic Acid	0-6	insulin	Homo sapiens	178-185
29501221-11	2018	CONCLUSIONS: Our study suggests a potential benefit of folate on insulin resistance and glycemic control; the latter requires examination in more high-quality trials.	Folic Acid	55-61	insulin	Homo sapiens	65-72
29231735-2	2018	This study observed that foliar salicylic acid treatment enhanced the accumulation of folates in Arabidopsis, which correlated with the increase in a folate binding protein (FBP) and the expression of mRNA of a putative folate binding protein At5G27830.	Folic Acid	86-93	folate receptor family protein	Arabidopsis thaliana	243-252
29360980-0	2018	Testicular MTHFR deficiency may explain sperm DNA hypomethylation associated with high dose folic acid supplementation.	Folic Acid	92-102	methylenetetrahydrofolate reductase	Mus musculus	11-16
31938300-11	2018	CONCLUSION: NaAsO2 induce embryonic cardiac defection and folate supplement alleviate this impairment through modulation of the Nkx2.5, GATA4 and TBX5 gene expression.	Folic Acid	58-64	NK2 homeobox 5	Rattus norvegicus	128-134
31938300-11	2018	CONCLUSION: NaAsO2 induce embryonic cardiac defection and folate supplement alleviate this impairment through modulation of the Nkx2.5, GATA4 and TBX5 gene expression.	Folic Acid	58-64	GATA binding protein 4	Rattus norvegicus	136-141
29725544-4	2018	The concentration of folate and vitamin B12 has been determined at t=0 and at 1, 8, and 13 years after storage at -80 C. The folate concentrations in serum samples remained stable at -80 C. The concentration of vitamin B12 was decreasing during the time of the study to about 50%.	Folic Acid	21-27	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	219-222
29358613-0	2018	Key apoptotic genes APAF1 and CASP9 implicated in recurrent folate-resistant neural tube defects.	Folic Acid	60-66	apoptotic peptidase activating factor 1	Homo sapiens	20-25
29283947-8	2018	Reduced NSCL/P risk was found with folic acid supplementation (P = 0.005), adequate maternal age (P = 0.002), and high parental education (P = 0.001).	Folic Acid	35-45	nescient helix-loop-helix 1	Homo sapiens	8-12
29283947-9	2018	The proper amount of folic acid, the appropriate age of childbearing, and the high education were the protective factors of NSCL/P, whereas family history, abortion history, drug use during pregnancy, maternal tobacco and alcohol, and maternal stress were the risk factors for NSCL/P in Yantai District, China.	Folic Acid	21-31	nescient helix-loop-helix 1	Homo sapiens	124-128
29439678-5	2018	RESULTS: With adjustment for lifestyle-related factors, including folate intake, the global DNA methylation level of peripheral blood leukocytes was significantly but weakly increased by 0.43% per quartile category for CRP (P for trend = 0.010).	Folic Acid	66-72	C-reactive protein	Homo sapiens	219-222
29162511-4	2018	METHODS: We investigated if major polymorphisms of folate-related genes, namely MTHFR c.677C>T, MTR c.2756A>G, MTRR c.66A>G and TYMS TSER (a 28-bp tandem repeat in the 5" promoter enhancer region of TYMS) increase the risk of pathological changes of the thymus in AChR+ MG patients.	Folic Acid	51-57	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	111-115
29377209-3	2018	Vitamin B12 might also have an independent role in NTD prevention, such that adding it in fortification programs might be more effective than fortifying with folic acid alone.	Folic Acid	158-168	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	8-11
29196155-10	2018	Treatment with iron and folic acid although has remarkable efficacy for Hb and body iron stores although for the cost of increasing the associated compartment of total bilirubin, AST and ALT concomitant with decreased GGT levels.	Folic Acid	24-34	solute carrier family 17 member 5	Homo sapiens	179-182
28185129-0	2018	Folic Acid Protects Against Glutamate-Induced Excitotoxicity in Hippocampal Slices Through a Mechanism that Implicates Inhibition of GSK-3beta and iNOS.	Folic Acid	0-10	nitric oxide synthase 2	Rattus norvegicus	147-151
28185129-7	2018	In addition, glutamate-treated hippocampal slices showed increased iNOS expression that was reversed by folic acid.	Folic Acid	104-114	nitric oxide synthase 2	Rattus norvegicus	67-71
28185129-8	2018	In conclusion, the results of this study show that the protective effect of folic acid against glutamate-induced excitotoxicity may involve the modulation of PI3K/GSK-3beta/beta-catenin pathway and iNOS inhibition.	Folic Acid	76-86	nitric oxide synthase 2	Rattus norvegicus	198-202
29540272-0	2018	Association of low dietary folate intake with lower CAMKK2 gene methylation, adiposity, and insulin resistance in obese subjects.	Folic Acid	27-33	insulin	Homo sapiens	92-99
29540272-9	2018	Subjects with total folate intake lower than 300mug/d showed more fat mass (especially trunk fat), as well as statistically higher levels of glucose, insulin, homeostatic model assessment-insulin resistance (HOMA-IR) index, cortisol, and plasminogen activator inhibitor-1 than those consuming at least or more than 300mug/d.	Folic Acid	20-26	insulin	Homo sapiens	150-157
29540272-9	2018	Subjects with total folate intake lower than 300mug/d showed more fat mass (especially trunk fat), as well as statistically higher levels of glucose, insulin, homeostatic model assessment-insulin resistance (HOMA-IR) index, cortisol, and plasminogen activator inhibitor-1 than those consuming at least or more than 300mug/d.	Folic Acid	20-26	insulin	Homo sapiens	188-195
29540272-13	2018	In summary, this study suggests associations between low folate intakes, lower CAMKK2 gene methylation, and insulin resistance in obese individuals.	Folic Acid	57-63	insulin	Homo sapiens	108-115
29159983-5	2018	METHODS: Association between population prevalence of 17 variants in 9 folate-related genes (MTRR, MTR, MTHFR, CBS, SHMT1, MTHFD1, RFC1, BHMT, TYMS) and the Fitzpatrick skin phototype of populations was assessed via collation of genotypic data from ALFRED (Allele Frequency Database) and 1000 Genomes databases.	Folic Acid	71-77	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	93-97
29159983-5	2018	METHODS: Association between population prevalence of 17 variants in 9 folate-related genes (MTRR, MTR, MTHFR, CBS, SHMT1, MTHFD1, RFC1, BHMT, TYMS) and the Fitzpatrick skin phototype of populations was assessed via collation of genotypic data from ALFRED (Allele Frequency Database) and 1000 Genomes databases.	Folic Acid	71-77	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	123-129
29190547-0	2018	Low-folate stress reprograms cancer stem cell-like potentials and bioenergetics metabolism through activation of mTOR signaling pathway to promote in vitro invasion and in vivo tumorigenicity of lung cancers.	Folic Acid	4-10	mechanistic target of rapamycin kinase	Homo sapiens	113-117
29474406-10	2018	Irrespective of cancer status, several SNPs were found to be associated with altered serum folate concentrations, including the D919G SNP in methionine synthase (MTR), the L474F SNP in serine hydroxymethyl transferase 1 (SHMT1) and the V175M SNP in phosphatidyl ethanolamine methyltransferase (PEMT).	Folic Acid	91-97	phosphatidylethanolamine N-methyltransferase	Homo sapiens	294-298
29231735-4	2018	Docking studies performed with At5G27830 confirmed specific binding of folic acid to predicted site.	Folic Acid	71-81	folate receptor family protein	Arabidopsis thaliana	31-40
29231735-5	2018	Heterologous expression of At5G27830 in the yeast resulted in significant uptake and accumulation of folic acid in cells.	Folic Acid	101-111	folate receptor family protein	Arabidopsis thaliana	27-36
29141866-0	2018	Prostate-specific membrane antigen cleavage of vitamin B9 stimulates oncogenic signaling through metabotropic glutamate receptors.	Folic Acid	47-57	folate hydrolase 1	Homo sapiens	0-34
29329322-4	2018	OBJECTIVES: We hypothesized that blocking folate metabolism through the loss of methylene-tetrahydrofolate reductase (Mthfr) activity would reduce the allergic airway disease phenotype through epigenetic mechanisms.	Folic Acid	42-48	methylenetetrahydrofolate reductase	Mus musculus	80-116
29329322-4	2018	OBJECTIVES: We hypothesized that blocking folate metabolism through the loss of methylene-tetrahydrofolate reductase (Mthfr) activity would reduce the allergic airway disease phenotype through epigenetic mechanisms.	Folic Acid	42-48	methylenetetrahydrofolate reductase	Mus musculus	118-123
29545905-10	2018	Conclusions: Our findings indicate that lower levels of vitamin B12 and folic acid associated with higher levels of homocysteine, S100B, and PCT point to a subgroup of depressed patients sensitive to ECT.	Folic Acid	72-82	S100 calcium binding protein B	Homo sapiens	130-135
29141866-5	2018	PSMA"s carboxypeptidase activity releases glutamate from vitamin B9 and other glutamated substrates, which activate mGluR I.	Folic Acid	57-67	folate hydrolase 1	Homo sapiens	0-4
30362096-2	2018	Alcohol consumption affects folate-related genes and enzymes including two major folate-metabolizing enzymes, ALDH1L1 and ALDH1L2.	Folic Acid	28-34	aldehyde dehydrogenase 1 family member L1	Homo sapiens	110-117
29342488-8	2018	The current meta-analysis showed folate supplementation among patients with metabolic diseases significantly decreased insulin (SMD -1.28; 95% CI, -1.99, -0.56) and homeostasis model assessment of insulin resistance (HOMA-IR) (SMD -1.28; 95% CI, -1.99, -0.56).	Folic Acid	33-39	insulin	Homo sapiens	119-126
30362096-2	2018	Alcohol consumption affects folate-related genes and enzymes including two major folate-metabolizing enzymes, ALDH1L1 and ALDH1L2.	Folic Acid	81-87	aldehyde dehydrogenase 1 family member L1	Homo sapiens	110-117
29342488-10	2018	The results of this meta-analysis study demonstrated that folate supplementation may result in significant decreases in insulin levels and HOMA-IR score, but does not affect FPG and HbA1c levels among patients with metabolic diseases.	Folic Acid	58-64	insulin	Homo sapiens	120-127
30362096-3	2018	ALDH1L1 (cytosolic 10-formyltetrahydrofolate dehydrogenase) is a regulatory enzyme in folate metabolism that controls the overall flux of one-carbon groups in folate-dependent biosynthetic pathways.	Folic Acid	38-44	aldehyde dehydrogenase 1 family member L1	Homo sapiens	0-7
30362096-3	2018	ALDH1L1 (cytosolic 10-formyltetrahydrofolate dehydrogenase) is a regulatory enzyme in folate metabolism that controls the overall flux of one-carbon groups in folate-dependent biosynthetic pathways.	Folic Acid	86-92	aldehyde dehydrogenase 1 family member L1	Homo sapiens	0-7
30362096-3	2018	ALDH1L1 (cytosolic 10-formyltetrahydrofolate dehydrogenase) is a regulatory enzyme in folate metabolism that controls the overall flux of one-carbon groups in folate-dependent biosynthetic pathways.	Folic Acid	86-92	aldehyde dehydrogenase 1 family member L1	Homo sapiens	9-58
29340279-2	2017	Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) are the two key regulatory enzymes in the folate/homocysteine (Hcy) metabolism.	Folic Acid	19-25	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	79-83
30378389-0	2018	The folic acid metabolism gene mel-32/Shmt is required for normal cell cycle lengths in Caenorhabditis elegans.	Folic Acid	4-14	Serine hydroxymethyltransferase	Caenorhabditis elegans	31-37
30378389-5	2018	mel-32 is an essential folic acid metabolism gene in C. elegans and a homolog to the mammalian enzyme serine hydroxymethyltransferase (Shmt).	Folic Acid	23-33	Serine hydroxymethyltransferase	Caenorhabditis elegans	0-6
29865064-3	2018	Reduced MTHFR activity is associated with alterations in folate and homocysteine metabolism.	Folic Acid	57-63	methylenetetrahydrofolate reductase	Mus musculus	8-13
29865064-6	2018	Notably, the effects of severe MTHFR deficiency in young mice are recapitulated by prolonged dietary folate deficiency in old mice, which leads to regional brain accumulation of cystathionine due to impaired methylation of homocysteine.	Folic Acid	101-107	methylenetetrahydrofolate reductase	Mus musculus	31-36
29376449-6	2018	In KB cells, uptake and Akt1 inhibition by F-LAN-RX-0201 were greater than those of non-targeted LAN-RX-0201 and could be partially blocked by excess free folate.	Folic Acid	155-161	AKT serine/threonine kinase 1	Homo sapiens	24-28
29848858-4	2018	We found that exposure to bisphenol A or folate deficiency during the fetal period changes the expressions of Xist, Tsix (the antisense repressor of Xist), and many X chromosome linked genes widely in newborn mice.	Folic Acid	41-47	X (inactive)-specific transcript, opposite strand	Mus musculus	116-120
27832722-1	2017	The loading efficacy of folic acid with serum proteins human serum albumin (HSA), bovine serum albumin (BSA), and beta-lactoglobulin (beta-LG) was analyzed and the effect of acid conjugation on protein morphology was determined.	Folic Acid	24-34	albumin	Homo sapiens	61-74
29070520-0	2017	Folic acid inhibits nasopharyngeal cancer cell proliferation and invasion via activation of FRalpha/ERK1/2/TSLC1 pathway.	Folic Acid	0-10	mitogen-activated protein kinase 3	Homo sapiens	100-106
29070520-0	2017	Folic acid inhibits nasopharyngeal cancer cell proliferation and invasion via activation of FRalpha/ERK1/2/TSLC1 pathway.	Folic Acid	0-10	cell adhesion molecule 1	Homo sapiens	107-112
29162466-4	2017	Experiments were conducted, using human embryonic kidney 293 cells transiently expressing the transporter to be examined, to assess the effects of myricetin (100 muM) on the uptake of folate by the PCFTs and riboflavin by hRFVT3.	Folic Acid	184-190	latexin	Homo sapiens	162-165
28814511-8	2017	PLD4 inhibition also prevented the folic acid-induced upregulation of this receptor in mouse kidneys.	Folic Acid	35-45	phospholipase D family, member 4	Mus musculus	0-4
27832722-1	2017	The loading efficacy of folic acid with serum proteins human serum albumin (HSA), bovine serum albumin (BSA), and beta-lactoglobulin (beta-LG) was analyzed and the effect of acid conjugation on protein morphology was determined.	Folic Acid	24-34	albumin	Homo sapiens	89-102
29340017-3	2017	Our data from clinical samples revealed the presence of aberrant DNA methylation in GNAS imprinting cluster in NTD samples with low folate concentrations.	Folic Acid	132-138	GNAS complex locus	Homo sapiens	84-88
29340017-6	2017	Imprinting in Exon1A/GNAS gDMR was abolished in both spermatozoa and oocytes upon treating with a parental folate-deficient diet (3.6% in spermatozoa, 9.8% in oocytes).	Folic Acid	107-113	GNAS complex locus	Homo sapiens	21-25
29340017-7	2017	Interestingly, loss of imprinting in the GNAS gene cluster altered chromatin structure to an overwhelmingly open structure (58.48% in the folate-free medium group vs. 39.51% in the folate-normal medium group; P &lt; 0.05), and led to a disturbed expression of genes in this region.	Folic Acid	138-144	GNAS complex locus	Homo sapiens	41-45
29340017-7	2017	Interestingly, loss of imprinting in the GNAS gene cluster altered chromatin structure to an overwhelmingly open structure (58.48% in the folate-free medium group vs. 39.51% in the folate-normal medium group; P &lt; 0.05), and led to a disturbed expression of genes in this region.	Folic Acid	181-187	GNAS complex locus	Homo sapiens	41-45
29340017-9	2017	Our results imply that GNAS imprinting plays major roles in folic acid metabolism regulation during embryogenesis.	Folic Acid	60-70	GNAS complex locus	Homo sapiens	23-27
29340017-10	2017	Aberrant GNAS imprinting is an attribute to NTDs, providing a new perspective for explaining the molecular mechanisms by which folate supplementation in human pregnancy provides protection from NTDs.	Folic Acid	127-133	GNAS complex locus	Homo sapiens	9-13
29142318-0	2017	The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD.	Folic Acid	40-46	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	89-94
28722335-0	2017	Protective effects of folic acid on PM2.5-induced cardiac developmental toxicity in zebrafish embryos by targeting AhR and Wnt/beta-catenin signal pathways.	Folic Acid	22-32	catenin (cadherin-associated protein), beta 1	Danio rerio	127-139
28906345-0	2017	Folic acid exerts antidepressant effects by upregulating brain-derived neurotrophic factor and glutamate receptor 1 expression in brain.	Folic Acid	0-10	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	95-115
28906345-6	2017	In conclusion, the results showed that folic acid significantly improved depression-like behaviors in CUMS-induced rats, and its antidepressant effects might be related to the increase of brain 5-HT concentration, BDNF and GluR1 expression, and repair of synaptic organization in the brain.	Folic Acid	39-49	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	223-228
28948692-2	2017	Folate transporters (SLC19A1, SLC46A1, SLC25A32, and FOLH1) and folate receptors (FOLR1, FOLR2, and FOLR3) are suggested to play essential roles in transporting folate from maternal intestinal lumen to the developing embryo.	Folic Acid	64-70	folate receptor gamma	Homo sapiens	100-105
28802835-0	2017	Residues in the eighth transmembrane domain of the proton-coupled folate transporter (SLC46A1) play an important role in defining the aqueous translocation pathway and in folate substrate binding.	Folic Acid	66-72	solute carrier family 46 member 1	Bos taurus	86-93
28802835-1	2017	The proton-coupled folate transporter (PCFT-SLC46A1) is required for intestinal folate absorption and folate transport across the choroid plexus.	Folic Acid	19-25	solute carrier family 46 member 1	Bos taurus	44-51
28150525-8	2017	In folic acid-treated rats, thrombin-induced calcium entry and release were decreased in platelet of control rats but unaltered in BDL rats; however, capacitative calcium entry was decreased in platelets of control and BDL rats treated with folic acid.	Folic Acid	3-13	coagulation factor II	Rattus norvegicus	28-36
28150525-8	2017	In folic acid-treated rats, thrombin-induced calcium entry and release were decreased in platelet of control rats but unaltered in BDL rats; however, capacitative calcium entry was decreased in platelets of control and BDL rats treated with folic acid.	Folic Acid	241-251	coagulation factor II	Rattus norvegicus	28-36
28969797-5	2017	Comparison of growth of WT and TARGET OF RAPAMYCIN (TOR) antisense lines indicates that folic acid acts by an alternative mechanism to this central regulator.	Folic Acid	88-98	target of rapamycin	Arabidopsis thaliana	31-50
28969797-5	2017	Comparison of growth of WT and TARGET OF RAPAMYCIN (TOR) antisense lines indicates that folic acid acts by an alternative mechanism to this central regulator.	Folic Acid	88-98	target of rapamycin	Arabidopsis thaliana	52-55
28814511-6	2017	Furthermore, therapeutic targeting of PLD4 using specific siRNA protected mice from folic acid-induced kidney fibrosis and inhibited the increase in TGF-beta signaling, decrease in NE expression, and upregulation of mitogen-activated protein kinase signaling.	Folic Acid	84-94	phospholipase D family, member 4	Mus musculus	38-42
28802835-1	2017	The proton-coupled folate transporter (PCFT-SLC46A1) is required for intestinal folate absorption and folate transport across the choroid plexus.	Folic Acid	80-86	solute carrier family 46 member 1	Bos taurus	44-51
28734179-2	2017	Methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) is one of the enzymes involved in folate metabolism.	Folic Acid	19-25	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	43-49
27714636-8	2017	Finally, the detections of folate concentration in human brain tissue and NSCs and MEF cells indicates that folate deficiency contributes to the observed decreases in Mark2 and Dvl1 expression.	Folic Acid	27-33	dishevelled segment polarity protein 1	Homo sapiens	177-181
27714636-8	2017	Finally, the detections of folate concentration in human brain tissue and NSCs and MEF cells indicates that folate deficiency contributes to the observed decreases in Mark2 and Dvl1 expression.	Folic Acid	108-114	dishevelled segment polarity protein 1	Homo sapiens	177-181
29132841-6	2017	Pg-3-glc and PGA at 0.08 mumol/L increased the concentration of IL-10 (P&lt;.01 and P&lt;.001, respectively), but there was no effect on tumor necrosis factor-alpha, IL-1beta, IL-6, and IL-8, and there were no effects of the other compounds.	Folic Acid	13-16	interleukin 1 beta	Homo sapiens	166-174
29132841-6	2017	Pg-3-glc and PGA at 0.08 mumol/L increased the concentration of IL-10 (P&lt;.01 and P&lt;.001, respectively), but there was no effect on tumor necrosis factor-alpha, IL-1beta, IL-6, and IL-8, and there were no effects of the other compounds.	Folic Acid	13-16	interleukin 6	Homo sapiens	176-180
29132841-6	2017	Pg-3-glc and PGA at 0.08 mumol/L increased the concentration of IL-10 (P&lt;.01 and P&lt;.001, respectively), but there was no effect on tumor necrosis factor-alpha, IL-1beta, IL-6, and IL-8, and there were no effects of the other compounds.	Folic Acid	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	186-190
28766937-4	2017	Interligand Overhauser effects indicate that metformin can form ternary complexes with p-aminobenzoyl-l-glutamate (pABG) as well as other ligands that occupy the region of the folate-binding site that interacts with pABG; however, DHFR inhibition is not cooperative.	Folic Acid	176-182	dihydrofolate reductase	Escherichia coli	231-235
28778621-1	2017	Methionine synthase reductase (MTRR) is one of the main regulatory enzymes in the homocysteine/folate pathway.	Folic Acid	95-101	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	0-29
28778621-1	2017	Methionine synthase reductase (MTRR) is one of the main regulatory enzymes in the homocysteine/folate pathway.	Folic Acid	95-101	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	31-35
28885600-7	2017	In the largest racial group, synthetic FA and the interaction of FOLH1 genotype with naturally occurring food folate significantly predicted RBC folate, with the overall model accounting for 13.8% of the variance in RBC folate levels.	Folic Acid	145-151	folate hydrolase 1	Homo sapiens	65-70
28885600-7	2017	In the largest racial group, synthetic FA and the interaction of FOLH1 genotype with naturally occurring food folate significantly predicted RBC folate, with the overall model accounting for 13.8% of the variance in RBC folate levels.	Folic Acid	145-151	folate hydrolase 1	Homo sapiens	65-70
28885600-8	2017	Blood folate levels rely on a complex interaction of natural and synthetic folate intake as well as FOLH1 genotype.	Folic Acid	6-12	folate hydrolase 1	Homo sapiens	100-105
28671341-3	2017	Folate (FA), which serves as an active ligand, is modified to the surface of MSN (MSN-FA) to enhance cell membrane translocation.	Folic Acid	0-6	moesin	Homo sapiens	77-80
28671341-3	2017	Folate (FA), which serves as an active ligand, is modified to the surface of MSN (MSN-FA) to enhance cell membrane translocation.	Folic Acid	0-6	moesin	Homo sapiens	82-88
28402324-10	2017	Higher maternal folate concentrations also predicted lower risk of vitamin B12 deficiency in infants (P&lt;0.05).	Folic Acid	16-22	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	75-78
28658642-4	2017	When the nanomicelles were tested in folate-receptor overexpressing ovarian and cervical cancer cells they exhibited high anticancer activity causing significant cell population to undergo apoptosis due to upregulation of tumor suppressor phosphatase and tensin homolog (PTEN) and inhibition of nuclear factor kappa-B (NFkappaB), which further confirmed the targeting ability and anticancer potentials of folate-targeted formulations.	Folic Acid	37-43	nuclear factor kappa B subunit 1	Homo sapiens	295-317
28658642-4	2017	When the nanomicelles were tested in folate-receptor overexpressing ovarian and cervical cancer cells they exhibited high anticancer activity causing significant cell population to undergo apoptosis due to upregulation of tumor suppressor phosphatase and tensin homolog (PTEN) and inhibition of nuclear factor kappa-B (NFkappaB), which further confirmed the targeting ability and anticancer potentials of folate-targeted formulations.	Folic Acid	37-43	nuclear factor kappa B subunit 1	Homo sapiens	319-327
28846595-0	2017	Maternal Prenatal Folic Acid Supplementation Programs Offspring Lipid Metabolism by Aberrant DNA Methylation in Hepatic ATGL and Adipose LPL in Rats.	Folic Acid	18-28	lipoprotein lipase	Rattus norvegicus	137-140
28624453-7	2017	The ability of folic acid to down-regulate HIF-1alpha and COX-2 protein levels was dramatically abrogated by L-NAME treatment, which also decreased eNOS mRNA and NO production.	Folic Acid	15-25	hypoxia inducible factor 1 subunit alpha	Homo sapiens	43-53
28835661-0	2017	Association between Serum Folate and Insulin Resistance among U.S. Nondiabetic Adults.	Folic Acid	26-32	insulin	Homo sapiens	37-44
28835661-2	2017	Folate is a key source of the one-carbon group for DNA methylation, whereas the association and mechanistic linkage between folate status and insulin resistance remains unclear with very limited experimental support.	Folic Acid	124-130	insulin	Homo sapiens	142-149
28835661-4	2017	We examined associations between serum folate and insulin resistance using multiple linear regression models adjusted for potential confounders.	Folic Acid	39-45	insulin	Homo sapiens	50-57
28835661-5	2017	We detected a significant inverse relationship for serum folate, where a 25% increase in serum folate was associated with a 3.06% (95% CI, -4.72, -1.37) and 2.77% (95% CI, -4.36, -1.77) decline in HOMA-IR and insulin respectively, and a 2.55% (95% CI, 0.93, 4.21) increase in G/I ratio.	Folic Acid	57-63	insulin	Homo sapiens	209-216
28835661-5	2017	We detected a significant inverse relationship for serum folate, where a 25% increase in serum folate was associated with a 3.06% (95% CI, -4.72, -1.37) and 2.77% (95% CI, -4.36, -1.77) decline in HOMA-IR and insulin respectively, and a 2.55% (95% CI, 0.93, 4.21) increase in G/I ratio.	Folic Acid	95-101	insulin	Homo sapiens	209-216
28835661-6	2017	Our findings demonstrate that serum folate was inversely associated with insulin resistance in U.S. nondiabetic adults.	Folic Acid	36-42	insulin	Homo sapiens	73-80
28624453-0	2017	Folic acid attenuates cobalt chloride-induced PGE2 production in HUVECs via the NO/HIF-1alpha/COX-2 pathway.	Folic Acid	0-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	83-93
28624453-0	2017	Folic acid attenuates cobalt chloride-induced PGE2 production in HUVECs via the NO/HIF-1alpha/COX-2 pathway.	Folic Acid	0-10	prostaglandin-endoperoxide synthase 2	Homo sapiens	94-99
28624453-5	2017	Folic acid also decreased cyclooxygenase-2 (COX-2) and hypoxia-inducible factor 1-alpha (HIF-1alpha) expression and altered endothelial nitric oxide synthase (eNOS) signaling by increasing p-eNOS(Ser1177) and decreasing p-eNOS(Thr495) in a dose-dependent manner.	Folic Acid	0-10	prostaglandin-endoperoxide synthase 2	Homo sapiens	26-42
28624453-5	2017	Folic acid also decreased cyclooxygenase-2 (COX-2) and hypoxia-inducible factor 1-alpha (HIF-1alpha) expression and altered endothelial nitric oxide synthase (eNOS) signaling by increasing p-eNOS(Ser1177) and decreasing p-eNOS(Thr495) in a dose-dependent manner.	Folic Acid	0-10	prostaglandin-endoperoxide synthase 2	Homo sapiens	44-49
28624453-5	2017	Folic acid also decreased cyclooxygenase-2 (COX-2) and hypoxia-inducible factor 1-alpha (HIF-1alpha) expression and altered endothelial nitric oxide synthase (eNOS) signaling by increasing p-eNOS(Ser1177) and decreasing p-eNOS(Thr495) in a dose-dependent manner.	Folic Acid	0-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	55-87
28624453-5	2017	Folic acid also decreased cyclooxygenase-2 (COX-2) and hypoxia-inducible factor 1-alpha (HIF-1alpha) expression and altered endothelial nitric oxide synthase (eNOS) signaling by increasing p-eNOS(Ser1177) and decreasing p-eNOS(Thr495) in a dose-dependent manner.	Folic Acid	0-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	89-99
28624453-5	2017	Folic acid also decreased cyclooxygenase-2 (COX-2) and hypoxia-inducible factor 1-alpha (HIF-1alpha) expression and altered endothelial nitric oxide synthase (eNOS) signaling by increasing p-eNOS(Ser1177) and decreasing p-eNOS(Thr495) in a dose-dependent manner.	Folic Acid	0-10	nitric oxide synthase 3	Homo sapiens	124-157
28771340-2	2017	Hence, a targeted drug delivery system (UA/siVEGF@MSN-FA) coloading ursolic acid (UA) and vascular endothelial growth factor (VEGF) targeted siRNA (siVEGF) based on mesoporous silica (MSN) nanocarrier modified by a folic acid (FA) molecule was designed and synthesized.	Folic Acid	215-225	moesin	Homo sapiens	50-53
28534241-3	2017	Genome-wide association studies (GWAS) revealed that human folate level could be significantly influenced by fidgetin (FIGN), methylenetetrahydrofolate reductase (MTHFR), prickle homolog 2 (PRICKLE2), synaptotagmin 9 (SYT9), gamma-aminobutyric acid B receptor 2 (GABBR2), and alkaline phosphatase (ALPL) genes.	Folic Acid	59-65	fidgetin, microtubule severing factor	Homo sapiens	109-117
28586467-8	2017	Exogenously supplied 5-formyl-tetrahydrofolate abrogated the mutant phenotypes, indicating that the fpgs1-4 mutant produced insufficient folate derivative levels.	Folic Acid	40-46	MUTM homolog-1	Arabidopsis thaliana	100-107
28748002-0	2017	High levels of circulating folate concentrations are associated with DNA methylation of tumor suppressor and repair genes p16, MLH1, and MGMT in elderly Chileans.	Folic Acid	27-33	cyclin dependent kinase inhibitor 2A	Homo sapiens	122-125
28748002-4	2017	RESULTS: We found that serum folate and to a lesser extent, vitamin B12 concentrations, were significantly correlated with DNA methylation of p16, MLH1, and MGMT, but not with LINE-1.	Folic Acid	29-35	cyclin dependent kinase inhibitor 2A	Homo sapiens	142-145
29123391-7	2017	Further functionalization of the NP with folic acid and/or transferrin (TF) offers a targeted delivery, as cancer cells overexpress folate and TF receptors, which can mediate the endocytosis of the NP carrying the drug.	Folic Acid	41-51	transferrin	Homo sapiens	143-145
29123391-8	2017	Thus, through the modification of AuNPs, we have been able to produce a nanocarrier containing GEM and folate/TF ligands, which is capable of targeted controlled-release delivery of the drug, reducing the side effects of the drug and increasing its efficacy.	Folic Acid	103-109	transferrin	Homo sapiens	110-112
28685231-4	2017	Here, a plasmid carrying specific shDNA (SHT-DNA), small interfering RNA (siRNA), and the peptide (P-17) were loaded separately into folic acid (FA)-functionalized nano-carriers made of Bovine Serum Albumin (BSA).	Folic Acid	133-143	family with sequence similarity 72 member B	Homo sapiens	99-103
28624453-7	2017	The ability of folic acid to down-regulate HIF-1alpha and COX-2 protein levels was dramatically abrogated by L-NAME treatment, which also decreased eNOS mRNA and NO production.	Folic Acid	15-25	prostaglandin-endoperoxide synthase 2	Homo sapiens	58-63
28624453-9	2017	Overall, these findings suggest a novel application for folic acid in attenuating CoCl2-induced PGE2 production in HUVECs via regulation of the NO/HIF-1alpha/COX-2 pathway.	Folic Acid	56-66	hypoxia inducible factor 1 subunit alpha	Homo sapiens	147-157
28624453-9	2017	Overall, these findings suggest a novel application for folic acid in attenuating CoCl2-induced PGE2 production in HUVECs via regulation of the NO/HIF-1alpha/COX-2 pathway.	Folic Acid	56-66	prostaglandin-endoperoxide synthase 2	Homo sapiens	158-163
28498159-11	2017	CRP only significantly correlated with FC (P = 0.0007) and PGA in the second trimester (P = 0.0003).	Folic Acid	59-62	C-reactive protein	Homo sapiens	0-3
29100299-4	2017	We found that MTX-conjugated NT4 allows drug resistance to be by-passed in MTX-resistant human breast cancer cells lacking expression of folate reduced carrier.	Folic Acid	137-143	neurotrophin 4	Homo sapiens	29-32
28586102-6	2017	After being encapsulated with biodegradable copolymer pluronic F-127-folic acid (F-127-FA), RET-BDP molecules can form uniform and small organic nanoparticles that are water soluble and tumor targetable.	Folic Acid	69-79	AT-rich interaction domain 3B	Homo sapiens	96-99
28537809-3	2017	Methionine synthase (MTR) and methionine synthase reductase (MTRR) are critical enzymes for the folate cycle.	Folic Acid	96-102	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	30-59
28537809-3	2017	Methionine synthase (MTR) and methionine synthase reductase (MTRR) are critical enzymes for the folate cycle.	Folic Acid	96-102	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	61-65
29133192-8	2017	The combined supplementation of folic acid, vitamin B12 and omega-3 fatty acids improved placental IL-10 levels and decreased TNF-alpha levels in offspring livers.	Folic Acid	32-42	tumor necrosis factor	Rattus norvegicus	126-135
28592519-8	2017	Folate sensing by mTOR in PHT cells is independent of the accumulation of homocysteine and requires the proton-coupled folate transporter (PCFT; solute carrier 46A1).	Folic Acid	0-6	mechanistic target of rapamycin kinase	Homo sapiens	18-22
28592519-11	2017	Low maternal folate concentrations are linked to restricted fetal growth, and we propose that the underlying mechanisms involve trophoblast mTOR folate sensing resulting in inhibition of mTORC1 and mTORC2 and downregulation of placental amino acid transporters.	Folic Acid	13-19	mechanistic target of rapamycin kinase	Homo sapiens	140-144
28592519-11	2017	Low maternal folate concentrations are linked to restricted fetal growth, and we propose that the underlying mechanisms involve trophoblast mTOR folate sensing resulting in inhibition of mTORC1 and mTORC2 and downregulation of placental amino acid transporters.	Folic Acid	145-151	mechanistic target of rapamycin kinase	Homo sapiens	140-144
28374905-17	2017	We propose that mTOR folate sensing in trophoblast cells matches placental nutrient transport, and therefore fetal growth, to folate availability.	Folic Acid	126-132	mechanistic target of rapamycin kinase	Homo sapiens	16-20
28374905-0	2017	mTOR folate sensing links folate availability to trophoblast cell function.	Folic Acid	5-11	mechanistic target of rapamycin kinase	Homo sapiens	0-4
28374905-0	2017	mTOR folate sensing links folate availability to trophoblast cell function.	Folic Acid	26-32	mechanistic target of rapamycin kinase	Homo sapiens	0-4
28374905-2	2017	Here we show that mechanistic target of rapamycin (mTOR) functions as a folate sensor in primary human trophoblast (PHT) cells.	Folic Acid	72-78	mechanistic target of rapamycin kinase	Homo sapiens	18-49
28685068-0	2017	Protein and mRNA expression of folic acid-associated enzymes as biomarkers for the cytotoxicity of the thymidylate synthase-targeted drugs, pemetrexed and S-1, in non-small cell lung cancer.	Folic Acid	31-41	proteasome 26S subunit, non-ATPase 1	Homo sapiens	155-158
28374905-2	2017	Here we show that mechanistic target of rapamycin (mTOR) functions as a folate sensor in primary human trophoblast (PHT) cells.	Folic Acid	72-78	mechanistic target of rapamycin kinase	Homo sapiens	51-55
28374905-3	2017	Folate sensing by mTOR in PHT cells involves both mTOR Complex 1 and 2 and requires the proton-coupled folate transporter.	Folic Acid	0-6	mechanistic target of rapamycin kinase	Homo sapiens	18-22
28374905-3	2017	Folate sensing by mTOR in PHT cells involves both mTOR Complex 1 and 2 and requires the proton-coupled folate transporter.	Folic Acid	0-6	mechanistic target of rapamycin kinase	Homo sapiens	50-54
28374905-5	2017	Because mTOR is a positive regulator of placental amino acid transport and mitochondrial function, placental mTOR folate sensing may constitute the mechanistic link between maternal folate status and fetal growth.	Folic Acid	114-120	mechanistic target of rapamycin kinase	Homo sapiens	8-12
28374905-5	2017	Because mTOR is a positive regulator of placental amino acid transport and mitochondrial function, placental mTOR folate sensing may constitute the mechanistic link between maternal folate status and fetal growth.	Folic Acid	114-120	mechanistic target of rapamycin kinase	Homo sapiens	109-113
28374905-5	2017	Because mTOR is a positive regulator of placental amino acid transport and mitochondrial function, placental mTOR folate sensing may constitute the mechanistic link between maternal folate status and fetal growth.	Folic Acid	182-188	mechanistic target of rapamycin kinase	Homo sapiens	8-12
28374905-5	2017	Because mTOR is a positive regulator of placental amino acid transport and mitochondrial function, placental mTOR folate sensing may constitute the mechanistic link between maternal folate status and fetal growth.	Folic Acid	182-188	mechanistic target of rapamycin kinase	Homo sapiens	109-113
28374905-10	2017	Here we show that mTOR functions as a folate sensor in primary human trophoblast (PHT) cells.	Folic Acid	38-44	mechanistic target of rapamycin kinase	Homo sapiens	18-22
28374905-12	2017	Folate sensing by mTOR in PHT cells involves both mTOR Complex 1 and 2 and requires the proton-coupled folate transporter (PCFT, SLC46A1).	Folic Acid	0-6	mechanistic target of rapamycin kinase	Homo sapiens	18-22
28374905-12	2017	Folate sensing by mTOR in PHT cells involves both mTOR Complex 1 and 2 and requires the proton-coupled folate transporter (PCFT, SLC46A1).	Folic Acid	0-6	mechanistic target of rapamycin kinase	Homo sapiens	50-54
28374905-13	2017	The involvement of PCFT in mTOR folate sensing is not dependent on its function as a plasma membrane folate transporter.	Folic Acid	32-38	mechanistic target of rapamycin kinase	Homo sapiens	27-31
28374905-14	2017	Increasing levels of homocysteine had no effect on PHT mTOR signalling, suggesting that mTOR senses low folate rather than high homocysteine.	Folic Acid	104-110	mechanistic target of rapamycin kinase	Homo sapiens	88-92
28374905-16	2017	We have identified a previously unknown molecular link between folate availability and cell function involving PCFT and mTOR signalling.	Folic Acid	63-69	mechanistic target of rapamycin kinase	Homo sapiens	120-124
28374905-17	2017	We propose that mTOR folate sensing in trophoblast cells matches placental nutrient transport, and therefore fetal growth, to folate availability.	Folic Acid	21-27	mechanistic target of rapamycin kinase	Homo sapiens	16-20
28482576-0	2017	Folate-decorated PEGylated triblock copolymer as a pH/reduction dual-responsive nanovehicle for targeted intracellular co-delivery of doxorubicin and Bcl-2 siRNA.	Folic Acid	0-6	BCL2 apoptosis regulator	Homo sapiens	150-155
28482576-3	2017	In this study, a novel folate-conjugated PEGylated cationic triblock copolymer, poly(acrylhydrazine)-block-poly(3-dimethylaminopropyl methacrylamide)-block-poly(acrylhydrazine) (PAH-b-PDMAPMA-b-PAH), was synthesized and evaluated as a stimuli-sensitive vehicle for the targeted co-delivery of doxorubicin (DOX) and Bcl-2 siRNA into breast cancer MCF-7 cells.	Folic Acid	23-29	BCL2 apoptosis regulator	Homo sapiens	315-320
28482576-11	2017	Confocal laser scanning microscopy, flow cytometry and MTT analyses confirmed that, compared with folate-undecorated nanomicelleplexes, folate-decorated nanomicelleplexes could more effectively co-deliver DOX and Bcl-2 siRNA into MCF-7 cells and showed a stronger cell-killing effect.	Folic Acid	136-142	BCL2 apoptosis regulator	Homo sapiens	213-218
28396257-10	2017	The second objective was to determine how a genetic deficiency in methylenetetrahydrofolate reductase (MTHFR), an enzyme involved in folate metabolism, increases vulnerability to stroke.	Folic Acid	85-91	methylenetetrahydrofolate reductase	Mus musculus	103-108
28685068-1	2017	The thymidylate synthase (TS)-targeted drugs, pemetrexed and S-1, exert an important role in advanced non-small cell lung cancer (NSCLC) treatment; folic acid-associated enzymes are expected to behave as biomarkers, although their role has yet to be fully elucidated.	Folic Acid	148-158	proteasome 26S subunit, non-ATPase 1	Homo sapiens	61-64
28288342-0	2017	Controlled release of insulin from folic acid-insulin complex nanoparticles.	Folic Acid	35-45	insulin	Homo sapiens	22-29
28548481-6	2017	We show that low-EpCAM expressing cells have higher collagen uptake and higher folate-induced NAD(P)H responses compared to those of high-EpCAM expressing cells.	Folic Acid	79-85	epithelial cell adhesion molecule	Homo sapiens	17-22
28288342-7	2017	Insulin release results suggest that more than 90% of the insulin is encapsulated and released within 24h from folic acid nanoparticles.	Folic Acid	111-121	insulin	Homo sapiens	0-7
28288342-7	2017	Insulin release results suggest that more than 90% of the insulin is encapsulated and released within 24h from folic acid nanoparticles.	Folic Acid	111-121	insulin	Homo sapiens	58-65
28288342-8	2017	The analysis of folic acid release along with insulin release indicates that the particles are formed by folic acid-insulin complexation at the molecular level.	Folic Acid	16-26	insulin	Homo sapiens	116-123
28288342-8	2017	The analysis of folic acid release along with insulin release indicates that the particles are formed by folic acid-insulin complexation at the molecular level.	Folic Acid	105-115	insulin	Homo sapiens	46-53
28288342-8	2017	The analysis of folic acid release along with insulin release indicates that the particles are formed by folic acid-insulin complexation at the molecular level.	Folic Acid	105-115	insulin	Homo sapiens	116-123
28288342-9	2017	The release of insulin from nanoparticles is controllable with the change in the crosslinking salt concentration as well as the amount of folic acid loaded during particle synthesis.	Folic Acid	138-148	insulin	Homo sapiens	15-22
28592519-3	2017	Here we review current data showing that folate sensing by mechanistic target of rapamycin (mTOR) constitutes a novel and distinct pathway by which folate modulates cell functions such as nutrient transport, protein synthesis, and mitochondrial respiration.	Folic Acid	41-47	mechanistic target of rapamycin kinase	Homo sapiens	92-96
28592519-3	2017	Here we review current data showing that folate sensing by mechanistic target of rapamycin (mTOR) constitutes a novel and distinct pathway by which folate modulates cell functions such as nutrient transport, protein synthesis, and mitochondrial respiration.	Folic Acid	148-154	mechanistic target of rapamycin kinase	Homo sapiens	92-96
32153830-14	2017	Women with folic acid deficiency had two times higher prevalence of having vitamin B12 deficiency.	Folic Acid	11-21	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	83-86
28100499-6	2017	Tubular epithelial cell-specific targeted deletion of Grem1 (TEC-grem1-cKO) mice displayed a milder response in the acute injury and recovery phases of the folic acid model.	Folic Acid	156-166	gremlin 1, DAN family BMP antagonist	Mus musculus	54-59
28100499-6	2017	Tubular epithelial cell-specific targeted deletion of Grem1 (TEC-grem1-cKO) mice displayed a milder response in the acute injury and recovery phases of the folic acid model.	Folic Acid	156-166	gremlin 1, DAN family BMP antagonist	Mus musculus	61-74
28100499-8	2017	In the recovery phase of the folic acid model, associated with renal fibrosis, TEC-grem1-cKO mice displayed reduced histological damage and an attenuated fibrotic gene response compared with wild-type controls.	Folic Acid	29-39	gremlin 1, DAN family BMP antagonist	Mus musculus	79-92
28603098-8	2017	The decrease trend in alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were stronger in the folic acid group compared to silymarin group (P=0.04 and P=0.007, respectively).	Folic Acid	111-121	solute carrier family 17 member 5	Homo sapiens	57-83
28603098-8	2017	The decrease trend in alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were stronger in the folic acid group compared to silymarin group (P=0.04 and P=0.007, respectively).	Folic Acid	111-121	solute carrier family 17 member 5	Homo sapiens	85-88
28288342-0	2017	Controlled release of insulin from folic acid-insulin complex nanoparticles.	Folic Acid	35-45	insulin	Homo sapiens	46-53
28288342-2	2017	This work leverages these interactions to engineer folic acid nanoparticles for controlled release of insulin during diabetes therapy.	Folic Acid	51-61	insulin	Homo sapiens	102-109
28288342-3	2017	The insulin-loaded folic acid nanoformulation is synthesized during this study to achieve better insulin loading and encapsulation than previous strategies.	Folic Acid	19-29	insulin	Homo sapiens	4-11
28288342-3	2017	The insulin-loaded folic acid nanoformulation is synthesized during this study to achieve better insulin loading and encapsulation than previous strategies.	Folic Acid	19-29	insulin	Homo sapiens	97-104
28489914-8	2017	The genotypes of miR-27a (AG and AG+GG) also showed significant contributions to the prediction of folate levels in RPL patients.	Folic Acid	99-105	microRNA 27a	Homo sapiens	17-24
28518056-1	2017	MHC class I-related molecule MR1 presents riboflavin- and folate-related metabolites to mucosal-associated invariant T cells, but it is unknown whether MR1 can present alternative antigens to other T cell lineages.	Folic Acid	58-64	major histocompatibility complex, class I-related	Homo sapiens	29-32
28881655-5	2017	Then, the correlation analysis between folate level, DNA methylation alteration in promoter and expression of CBS was carried out in vitro and vivo.	Folic Acid	39-45	cystathionine beta-synthase	Homo sapiens	110-113
28603593-7	2017	Folic acid concentration [5.4 (4.4-7.9) ng/mL vs 12.2 (8.0-14.2) ng/mL, P &lt; 0.01] resulted to be lower and High-sensitivity C reactive protein levels higher (4.21 +- 6.47 mg/L vs 0.98 +- 1.13 mg/L, P &lt; 0.01) in the patient group.	Folic Acid	0-10	C-reactive protein	Homo sapiens	127-145
28484595-6	2017	Supplementing functional amino acids (e.g., arginine and glutamine) and vitamins (e.g., folate) play a key role in activating the mammalian target of rapamycin signaling and regulating the provision of methyl donors for DNA and protein methylation.	Folic Acid	88-94	mechanistic target of rapamycin kinase	Homo sapiens	130-159
28404799-5	2017	In further stratified analyses among trials without folic acid fortification, a larger beneficial effect was found in those trials that used a low dosage of folic acid (&lt;=0.8 mg: 0.78, 0.69-0.88) or low baseline vitamin B12 levels (&lt;384 pg/mL: 0.78, 0.68-0.89).	Folic Acid	157-167	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	223-226
28404799-8	2017	CONCLUSIONS: Folic acid supplementation could reduce the stroke risk in regions without folic acid fortification, particularly in trials using a relatively low dosage of folic acid and with low vitamin B12 levels.	Folic Acid	13-23	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	202-205
28475147-6	2017	Folic acid reduced atherosclerotic lesion size in ApoE knockout mice.	Folic Acid	0-10	apolipoprotein E	Mus musculus	50-54
20301703-11	1993	Pregnancy management: Folic acid supplementation in pregnancy is recommended for women at increased risk of having a child with WS1 because of possibly increased risk for neural tube defects in association with WS1.	Folic Acid	22-32	paired box 3	Homo sapiens	128-131
20301703-11	1993	Pregnancy management: Folic acid supplementation in pregnancy is recommended for women at increased risk of having a child with WS1 because of possibly increased risk for neural tube defects in association with WS1.	Folic Acid	22-32	paired box 3	Homo sapiens	211-214
28300564-1	2017	ABCG2 is a membrane transport protein that effluxes growth-promoting molecules, such as folates and dihydrotestosterone, as well as chemotherapeutic agents.	Folic Acid	88-95	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	0-5
28398657-1	2017	BACKGROUND: This investigation determines the nutritional state of serum and red blood cell (RBC) folate concentration and their relation with intake of folate, B6 ,and B12 , with serum vitamin B12 , and with genetic variants after provision of 400 mug/day of folic acid for 3 months to a group of 34 Colombian women of reproductive age.	Folic Acid	98-104	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	169-172
28302752-0	2017	Lower Circulating Folate Induced by a Fidgetin Intronic Variant Is Associated With Reduced Congenital Heart Disease Susceptibility.	Folic Acid	18-24	fidgetin, microtubule severing factor	Homo sapiens	38-46
28423731-3	2017	The faster release of curcumin from the folate-conjugated curcumin and paclitaxel-loaded lipid nanoparticles enables sufficient p-glycoprotein inhibition, which allows increased cellular uptake and cytotoxicity of paclitaxel.	Folic Acid	40-46	ATP binding cassette subfamily B member 1	Homo sapiens	128-142
28300564-5	2017	Transport studies showed that wild-type ABCG2 was able to efflux more folic acid than the Q141K variant (P&lt;0.002), suggesting that retained tumoral folate contributes to the decreased time to PSA recurrence in the Q141K variant patients.	Folic Acid	70-80	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	40-45
28300564-5	2017	Transport studies showed that wild-type ABCG2 was able to efflux more folic acid than the Q141K variant (P&lt;0.002), suggesting that retained tumoral folate contributes to the decreased time to PSA recurrence in the Q141K variant patients.	Folic Acid	151-157	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	40-45
28185938-0	2017	Folate-targeted nanoparticle delivery of androgen receptor shRNA enhances the sensitivity of hormone-independent prostate cancer to radiotherapy.	Folic Acid	0-6	androgen receptor	Homo sapiens	41-58
28432945-0	2017	Exploring isoxsuprine hydrochloride binding with human serum albumin in the presence of folic acid and ascorbic acid using multispectroscopic and molecular modeling methods.	Folic Acid	88-98	albumin	Homo sapiens	55-68
28185938-4	2017	In this study, nanoparticle (NP) AR-shRNA was formulated using folate-targeted H1 nanopolymer.	Folic Acid	63-69	androgen receptor	Homo sapiens	33-35
28007895-3	2017	HIF-1 also mediates increased flux through the serine synthesis pathway and mitochondrial one-carbon (folate cycle) metabolism to increase mitochondrial antioxidant production (NADPH and glutathione).	Folic Acid	102-108	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
32263989-4	2017	P-Glycoprotein inhibition by TPGS and folate-mediated targeted delivery helped overcome multidrug resistance (MDR) and increase the therapeutic efficiency of the drug, leading to good anticancer effects in the MCF-7/ADR xenograft model.	Folic Acid	38-44	ATP binding cassette subfamily B member 1	Homo sapiens	0-14
28445960-8	2017	Folate deficiency significantly reduced the expression of ESR1, CAV1, and ELAVL1, which are critical to spermatogenesis.	Folic Acid	0-6	estrogen receptor 1	Homo sapiens	58-62
28445960-8	2017	Folate deficiency significantly reduced the expression of ESR1, CAV1, and ELAVL1, which are critical to spermatogenesis.	Folic Acid	0-6	caveolin 1	Homo sapiens	64-68
28191959-0	2017	Mitoxantrone- and Folate-TPGS2k Conjugate Hybrid Micellar Aggregates To Circumvent Toxicity and Enhance Efficiency for Breast Cancer Therapy.	Folic Acid	18-24	tubulin polyglutamylase complex subunit 2	Homo sapiens	25-30
28702146-1	2017	BACKGROUND: The 5, 10-methyleneterahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) are two essential enzymes involved in folate metabolism.	Folic Acid	40-46	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	69-98
28702146-1	2017	BACKGROUND: The 5, 10-methyleneterahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) are two essential enzymes involved in folate metabolism.	Folic Acid	40-46	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	100-104
27662903-8	2017	Finally, simvastatin and the polyphenol quercetin potentiated the antiproliferative effect of insulin; on the contrary, the polyphenol resveratrol, the polyunsaturated fatty acids eicosapentaenoic and docosahexaenoic acids, and folic acid were not able to change it.	Folic Acid	228-238	insulin	Homo sapiens	94-101
28345611-8	2017	Disruption of the genes NUP98 (embryonic stem cell development) and MTRR (folate metabolism) was detected exclusively in RPL placentas, potentially indicative to novel loci implicated in RPL.	Folic Acid	74-80	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	68-72
27924000-7	2017	Supplement of folate resulted in a restored UBF binding across DNA breakage sites of rRNA genes, and normal rRNA gene transcription.	Folic Acid	14-20	upstream binding transcription factor, RNA polymerase I	Mus musculus	44-47
27924000-8	2017	In samples from neural tube defects (NTDs) with low folate level, up-regulation of rRNA gene transcription was observed, along with aberrant UBF level.	Folic Acid	52-58	upstream binding transcription factor, RNA polymerase I	Mus musculus	141-144
28152548-7	2017	In the largest tumours, only found in mice on high folic acid diet, STAT3 was activated.	Folic Acid	51-61	signal transducer and activator of transcription 3	Mus musculus	68-73
28152548-8	2017	In primary cells from PyMT tumours, STAT3 was activated upon treatment with folic acid in culture.	Folic Acid	76-86	signal transducer and activator of transcription 3	Mus musculus	36-41
27362407-10	2017	When the cytokine levels were divided into quartiles, lower folate and vitamin B6 intake was associated with the highest levels of IL-4 in neonatal cord blood (p&lt;0.05), and higher folate and vitamin B6 intake was associated with highest levels of IFN-gamma in neonatal cord blood.	Folic Acid	60-66	interleukin 4	Homo sapiens	131-135
27362407-10	2017	When the cytokine levels were divided into quartiles, lower folate and vitamin B6 intake was associated with the highest levels of IL-4 in neonatal cord blood (p&lt;0.05), and higher folate and vitamin B6 intake was associated with highest levels of IFN-gamma in neonatal cord blood.	Folic Acid	60-66	interferon gamma	Homo sapiens	250-259
27362407-11	2017	CONCLUSIONS: In this study, a strong association between IL-4 and IFN-gamma levels in cord blood and the intake of folate and vitamin B6 was found, which indicates that food intake during pregnancy might have a strong influence on IL-4 and IFN-gamma levels in cord blood, to a greater extent than environmental factors.	Folic Acid	115-121	interleukin 4	Homo sapiens	57-61
27362407-11	2017	CONCLUSIONS: In this study, a strong association between IL-4 and IFN-gamma levels in cord blood and the intake of folate and vitamin B6 was found, which indicates that food intake during pregnancy might have a strong influence on IL-4 and IFN-gamma levels in cord blood, to a greater extent than environmental factors.	Folic Acid	115-121	interferon gamma	Homo sapiens	66-75
27362407-11	2017	CONCLUSIONS: In this study, a strong association between IL-4 and IFN-gamma levels in cord blood and the intake of folate and vitamin B6 was found, which indicates that food intake during pregnancy might have a strong influence on IL-4 and IFN-gamma levels in cord blood, to a greater extent than environmental factors.	Folic Acid	115-121	interleukin 4	Homo sapiens	231-235
27362407-11	2017	CONCLUSIONS: In this study, a strong association between IL-4 and IFN-gamma levels in cord blood and the intake of folate and vitamin B6 was found, which indicates that food intake during pregnancy might have a strong influence on IL-4 and IFN-gamma levels in cord blood, to a greater extent than environmental factors.	Folic Acid	115-121	interferon gamma	Homo sapiens	240-249
28069796-0	2017	High dietary folate in pregnant mice leads to pseudo-MTHFR deficiency and altered methyl metabolism, with embryonic growth delay and short-term memory impairment in offspring.	Folic Acid	13-19	methylenetetrahydrofolate reductase	Mus musculus	53-58
28069796-16	2017	In summary, high folate intake during pregnancy leads to pseudo-MTHFR deficiency, disturbed choline/methyl metabolism, embryonic growth delay and memory impairment in offspring.	Folic Acid	17-23	methylenetetrahydrofolate reductase	Mus musculus	64-69
28214085-0	2017	Folic acid protects against lead acetate-induced hepatotoxicity by decreasing NF-kappaB, IL-1beta production and lipid peroxidation mediataed cell injury.	Folic Acid	0-10	interleukin 1 beta	Rattus norvegicus	89-97
28214085-13	2017	In conclusion, folic acid protects against lead acetate-induced hepatotoxicity by decreasing NF-kappaB, IL-1beta production and lipid peroxidation mediataed cell injury.	Folic Acid	15-25	interleukin 1 beta	Rattus norvegicus	104-112
28261276-9	2017	Intake of methyl donating nutrients including folate was positively associated LINE-1 methylation and negatively associated with IFNgamma CpG-186.	Folic Acid	46-52	interferon gamma	Homo sapiens	129-137
28055982-1	2017	Herein, we prepared folate-targeting core crosslinked polymeric micelles (CCL/FA) containing multiple disulfide bonds located at the interface and core of the micelles to co-deliver doxorubicin (DOX) and the P-glycoprotein (P-gp) inhibitor tariquidar (TQR) for reversing drug resistance.	Folic Acid	20-26	ATP binding cassette subfamily B member 1	Homo sapiens	208-222
28137868-0	2017	Elucidation of roles for vitamin B12 in regulation of folate, ubiquinone, and methionine metabolism.	Folic Acid	54-60	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	33-36
28137868-4	2017	First, we identified a light-sensing B12-binding transcriptional regulator and demonstrated that it controls folate and ubiquinone biosynthesis.	Folic Acid	109-115	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	37-40
28059521-5	2017	SRLS is applied to 4-oxalocrotonate tautomerase (4-OT), the acyl-coenzyme A binding protein (ACBP), the C-terminal SH2 domain of phospholipase Cgamma1 (PLCgamma1C SH2), the construct dihydrofolate reductase-E:folate (DHFR-E:folate), and their complexes with appropriate ligands, to determine DeltaS.	Folic Acid	190-196	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	93-97
28422052-13	2017	In addition, PP2A methylation and DNMT1 mRNA expression were significantly increased in DM mice post folic acid treatment.	Folic Acid	101-111	DNA methyltransferase (cytosine-5) 1	Mus musculus	34-39
28406978-11	2017	These results suggest that a deficiency of serum folate and high hemoglobin levels may reflect an increased risk of amyloid beta accumulation in the brain.	Folic Acid	49-55	amyloid beta precursor protein	Homo sapiens	116-128
28406978-13	2017	This study reveals that the combined assessment of serum folate levels and red blood cell hemoglobin content may be a useful biomarker for amyloid beta accumulation in the brain.	Folic Acid	57-63	amyloid beta precursor protein	Homo sapiens	139-151
28039583-3	2017	The aim of this pilot study was to evaluate the hypothesis that DCI plus folic acid may improve glucose control reducing insulin resistance in overweight or obese T1D patients.	Folic Acid	73-83	insulin	Homo sapiens	121-128
26795217-9	2017	All vitamins except B12 and folic acid correlated positively with total osteocalcin and negatively with bone-specific alkaline phosphatase.	Folic Acid	28-38	bone gamma-carboxyglutamate protein	Homo sapiens	72-83
28540268-9	2017	CONCLUSION: High dose of folic acid supplementation could decrease bone resorptive biomarkers and may prevent PAO in pregnant women by increasing OPG and decreasing sRANKL and TNFalpha.	Folic Acid	25-35	tumor necrosis factor	Homo sapiens	176-184
28250194-1	2017	Background: Previously, we determined that heterogeneous nuclear ribonucleoprotein E1 (hnRNP-E1) functions as an intracellular physiologic sensor of folate deficiency.	Folic Acid	149-155	poly(rC) binding protein 1	Homo sapiens	43-85
28250194-1	2017	Background: Previously, we determined that heterogeneous nuclear ribonucleoprotein E1 (hnRNP-E1) functions as an intracellular physiologic sensor of folate deficiency.	Folic Acid	149-155	poly(rC) binding protein 1	Homo sapiens	87-95
28250194-2	2017	In this model, l-homocysteine, which accumulates intracellularly in proportion to the extent of folate deficiency, covalently binds to and thereby activates homocysteinylated hnRNP-E1 to interact with folate receptor-alpha mRNA; this high-affinity interaction triggers the translational upregulation of cell surface folate receptors, which enables cells to optimize folate uptake from the external milieu.	Folic Acid	96-102	poly(rC) binding protein 1	Homo sapiens	175-183
28250194-2	2017	In this model, l-homocysteine, which accumulates intracellularly in proportion to the extent of folate deficiency, covalently binds to and thereby activates homocysteinylated hnRNP-E1 to interact with folate receptor-alpha mRNA; this high-affinity interaction triggers the translational upregulation of cell surface folate receptors, which enables cells to optimize folate uptake from the external milieu.	Folic Acid	201-207	poly(rC) binding protein 1	Homo sapiens	175-183
28250194-7	2017	Finally, folate deficiency induced dual upregulation of hnRNP-E1 and folate receptors in cultured human cells and tumor xenografts, and more selectively in various fetal tissues of folate-deficient dams.Conclusions: This novel positive feedback loop amplifies hnRNP-E1 during prolonged folate deficiency and thereby maximizes upregulation of folate receptors in order to restore folate homeostasis toward normalcy in placental cells.	Folic Acid	9-15	poly(rC) binding protein 1	Homo sapiens	56-64
28250194-7	2017	Finally, folate deficiency induced dual upregulation of hnRNP-E1 and folate receptors in cultured human cells and tumor xenografts, and more selectively in various fetal tissues of folate-deficient dams.Conclusions: This novel positive feedback loop amplifies hnRNP-E1 during prolonged folate deficiency and thereby maximizes upregulation of folate receptors in order to restore folate homeostasis toward normalcy in placental cells.	Folic Acid	9-15	poly(rC) binding protein 1	Homo sapiens	260-268
28250194-8	2017	It will also functionally impact several other mRNAs of the nutrition-sensitive, folate-responsive posttranscriptional RNA operon that is orchestrated by homocysteinylated hnRNP-E1.	Folic Acid	81-87	poly(rC) binding protein 1	Homo sapiens	172-180
28407838-13	2017	The methylation levels of IGF-1R, IGF-2R, IGFBP-2, IGFBP-5, IGFBP-6 and IGFBP-7 in the fetal brain were higher in the folate deficient group than in the control group (P&lt;0.05).	Folic Acid	118-124	insulin-like growth factor binding protein 2	Rattus norvegicus	42-49
28407838-13	2017	The methylation levels of IGF-1R, IGF-2R, IGFBP-2, IGFBP-5, IGFBP-6 and IGFBP-7 in the fetal brain were higher in the folate deficient group than in the control group (P&lt;0.05).	Folic Acid	118-124	insulin-like growth factor binding protein 6	Rattus norvegicus	60-67
28386356-0	2017	Folic acid inhibits dedifferentiation of PDGF-BB-induced vascular smooth muscle cells by suppressing mTOR/P70S6K signaling.	Folic Acid	0-10	mechanistic target of rapamycin kinase	Homo sapiens	101-105
28386356-15	2017	CONCLUSION: Folic acid inhibits dedifferentiation of PDGF-BB-induced VSMCs by suppressing mTOR/P70S6K signaling.	Folic Acid	12-22	mechanistic target of rapamycin kinase	Homo sapiens	90-94
28288183-9	2017	The highest user rate was observed for the substrates of multidrug resistance-associated protein 1, mainly folic acid (6% of cases, 8% of referents), and breast cancer resistance protein, mainly nitrofurantoin (2.3% of cases, 2.9% of referents).	Folic Acid	107-117	ATP binding cassette subfamily C member 1	Homo sapiens	57-98
28174106-0	2017	Radiosynthesis and evaluation of a 99mTc-folic acid radiotracer prepared using [99mTcN(PNP)]2+ metal fragment.	Folic Acid	41-51	purine nucleoside phosphorylase	Homo sapiens	87-90
28174106-3	2017	To overcome this, a new 99mTc labeled folic acid was synthesized via the use of [99mTcN(PNP)]2+ metal fragment, where the presence of the latter pharmacophore redirects in vivo clearance via the hepatobiliary pathway.	Folic Acid	38-48	purine nucleoside phosphorylase	Homo sapiens	88-91
28174106-6	2017	The route followed herein to prepare a folic-acid based radiotracer constitutes the first report of radiolabeling folic acid using the [99mTcN(PNP)]2+ as a radiosynthon.	Folic Acid	39-49	purine nucleoside phosphorylase	Homo sapiens	143-146
28174106-6	2017	The route followed herein to prepare a folic-acid based radiotracer constitutes the first report of radiolabeling folic acid using the [99mTcN(PNP)]2+ as a radiosynthon.	Folic Acid	114-124	purine nucleoside phosphorylase	Homo sapiens	143-146
28174106-7	2017	Modification in the structure of conjugate by linking the BFCA through a long-chain linker can be envisaged to improve the affinity of [99mTcN(PNP)]-folic acid complex towards FRs.	Folic Acid	149-159	purine nucleoside phosphorylase	Homo sapiens	143-146
27876554-0	2017	Interaction between excess folate and low vitamin B12 status.	Folic Acid	27-33	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	50-53
27876554-5	2017	This review summarizes the current knowledge on the interaction between folate and vitamin B12 and the associated health outcomes.	Folic Acid	72-78	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	91-94
28174570-5	2017	ESBL-producing E. coli exhibited highly resistant to penicillin derivatives, fluoroquinolones, folate pathway inhibitors, and third-generation cephalosporins, but no carbapenem-resistant isolates were found in this study.	Folic Acid	95-101	EsbL	Escherichia coli	0-4
28008752-8	2017	Fpn1 deficiency resulted in reduced folate levels in both pregnant dams and embryos.	Folic Acid	36-42	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	0-4
28243331-1	2017	Methionine synthase reductase (MTRR) is a key regulatory enzyme involved in the folate metabolic pathway.	Folic Acid	80-86	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	0-29
28243331-1	2017	Methionine synthase reductase (MTRR) is a key regulatory enzyme involved in the folate metabolic pathway.	Folic Acid	80-86	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	31-35
27378204-1	2016	In this study, shRNA against VEGFA was packaged in bacterial minicells and surface of minicells was modified with folic acid.	Folic Acid	114-124	vascular endothelial growth factor A	Homo sapiens	29-34
28118645-1	2017	Polymorphisms in genes encoding the enzymes involved in the metabolism of homocysteine, such as methionine synthase (MTR) and methionine synthase reductase (MTRR), play an important function in the metabolism of folic acid and vitamin B12.	Folic Acid	212-222	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	126-155
28118645-1	2017	Polymorphisms in genes encoding the enzymes involved in the metabolism of homocysteine, such as methionine synthase (MTR) and methionine synthase reductase (MTRR), play an important function in the metabolism of folic acid and vitamin B12.	Folic Acid	212-222	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	157-161
27998415-8	2016	An additive interaction was seen between serum folate deficiency and high expression of p16 protein in the CINI, CINII/III and SCC group.	Folic Acid	47-53	cyclin dependent kinase inhibitor 2A	Homo sapiens	88-91
27998415-12	2016	Our findings suggested that folic acid supplementation could reverse the abnormal expression of p16 protein, and effectively promote apoptosis and inhibit proliferation in cervical carcinoma cells.	Folic Acid	28-38	cyclin dependent kinase inhibitor 2A	Homo sapiens	96-99
27061263-6	2016	RESULTS AND LIMITATIONS: Higher folate and vitamin B12 concentrations were associated with a small increase in risk of PCa (ORs for the top vs bottom fifths were 1.13 [95% confidence interval (CI), 1.02-1.26], ptrend=0.018, for folate and 1.12 [95% CI, 1.01-1.25], ptrend=0.017, for vitamin B12), with no evidence of heterogeneity between studies.	Folic Acid	228-234	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	51-54
29195878-3	2016	LLC is able to produce 95.25+-26mug L-1 of folate, during 10h, and was encapsulated in the APACM.	Folic Acid	43-49	immunoglobulin kappa variable 1-16	Homo sapiens	36-39
28105160-2	2016	Therefore, the present study aimed to investigate the association between serum folate deficiency and abnormal expression of the cell adhesion molecule 1 (CADM1) protein in the progression of LSCC.	Folic Acid	80-86	cell adhesion molecule 1	Homo sapiens	129-153
28105160-2	2016	Therefore, the present study aimed to investigate the association between serum folate deficiency and abnormal expression of the cell adhesion molecule 1 (CADM1) protein in the progression of LSCC.	Folic Acid	80-86	cell adhesion molecule 1	Homo sapiens	155-160
27917408-5	2016	The presence of folic acid allowed efficient targeting of the PSMA receptor and subsequent internalization of the polymeric vesicles in cultured LNCaP prostate cancer cell spheroids.	Folic Acid	16-26	folate hydrolase 1	Homo sapiens	62-66
27682214-0	2016	Aerosol delivery of folate-decorated hyperbranched polyspermine complexes to suppress lung tumorigenesis via Akt signaling pathway.	Folic Acid	20-26	AKT serine/threonine kinase 1	Homo sapiens	109-112
27857162-4	2016	In mice with folic acid-induced AKI, delayed treatment with Tanshinone IIA, commenced early or late after injury, diminished renal expression of kidney injury markers, reduced apoptosis and improved kidney dysfunction, concomitant with mitigated histologic signs of AKI to CKD transition, including interstitial fibrosis and tubular atrophy, and with an ameliorated inflammatory infiltration in tubulointerstitium and a favored M2-skewed macrophage polarization.	Folic Acid	13-23	ATPase, class II, type 9A	Mus musculus	71-74
27707701-14	2016	These findings have implications for women with high folate intakes, particularly if they are polymorphic for MTHFD1 R653Q.	Folic Acid	53-59	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	110-116
27389146-1	2016	In this study, a folate targeted cyclodextrin (CD) nanoparticle was prepared by co-formulating CD.siRNA complexes with DSPE-PEG5000-folate to target the prostate specific membrane antigen (PSMA).	Folic Acid	17-23	folate hydrolase 1	Homo sapiens	189-193
27389146-1	2016	In this study, a folate targeted cyclodextrin (CD) nanoparticle was prepared by co-formulating CD.siRNA complexes with DSPE-PEG5000-folate to target the prostate specific membrane antigen (PSMA).	Folic Acid	132-138	folate hydrolase 1	Homo sapiens	153-187
27389146-3	2016	Competitive uptake studies, using excess folate, significantly reduced uptake of targeted nanoparticles in PSMA positive cell lines (P&lt;0.001).	Folic Acid	41-47	folate hydrolase 1	Homo sapiens	107-111
27389146-7	2016	This study highlights the ability of incorporating a folate ligand into CD.siRNA nanoparticles to allow for targeted delivery of siRNA to prostate cancer cells via the PSMA.	Folic Acid	53-59	folate hydrolase 1	Homo sapiens	168-172
28149019-8	2017	Serum folate and ferritin levels were significantly lower in females with lower CD4 levels.	Folic Acid	6-12	CD4 molecule	Homo sapiens	80-83
28552882-6	2017	After administration of 15 mg of folic acid to patients with primary hypertension, a considerable decrease in the concentration of homocysteine was observed in parallel with a substantive growth of HDL-cholesterol, as well as apoprotein AI concentrations and a reduction of the apoprotein B concentration.	Folic Acid	33-43	apolipoprotein A1	Homo sapiens	226-239
28552882-6	2017	After administration of 15 mg of folic acid to patients with primary hypertension, a considerable decrease in the concentration of homocysteine was observed in parallel with a substantive growth of HDL-cholesterol, as well as apoprotein AI concentrations and a reduction of the apoprotein B concentration.	Folic Acid	33-43	apolipoprotein B	Homo sapiens	278-290
28552882-7	2017	Results of statistical analysis indicated a significant correlation between the decline in homocysteine concentration and the increase in HDL-cholesterol concentration, as well as between the increase of folic acid concentration and the increase in apoAI concentration in patients following the intake of folic acid.	Folic Acid	204-214	apolipoprotein A1	Homo sapiens	249-254
28552882-7	2017	Results of statistical analysis indicated a significant correlation between the decline in homocysteine concentration and the increase in HDL-cholesterol concentration, as well as between the increase of folic acid concentration and the increase in apoAI concentration in patients following the intake of folic acid.	Folic Acid	305-315	apolipoprotein A1	Homo sapiens	249-254
27676194-0	2017	Folic Acid Supports Pluripotency and Reprogramming by Regulating LIF/STAT3 and MAPK/ERK Signaling.	Folic Acid	0-10	signal transducer and activator of transcription 3	Mus musculus	69-74
27676194-0	2017	Folic Acid Supports Pluripotency and Reprogramming by Regulating LIF/STAT3 and MAPK/ERK Signaling.	Folic Acid	0-10	mitogen-activated protein kinase 1	Mus musculus	84-87
27693961-0	2016	Molecular and cellular effects of vitamin B12 forms on human trophoblast cells in presence of excessive folate.	Folic Acid	104-110	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	42-45
27693961-12	2016	Combination of B12 active forms i.e. MeCbl+AdCbl was found to be most effective in neutralising excess folate effect in-vitro.	Folic Acid	103-109	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	15-18
27832994-5	2016	Supplementation with folic acid and vitamin B12 suppressed the nicotine induced changes in HbA1c, insulin, TNF-alpha, IL-6, generation of reactive oxygen species, and attenuated the changes in markers of oxidative stress.	Folic Acid	21-31	tumor necrosis factor	Rattus norvegicus	107-116
27832994-5	2016	Supplementation with folic acid and vitamin B12 suppressed the nicotine induced changes in HbA1c, insulin, TNF-alpha, IL-6, generation of reactive oxygen species, and attenuated the changes in markers of oxidative stress.	Folic Acid	21-31	interleukin 6	Rattus norvegicus	118-122
27832994-6	2016	Moreover, folic acid and vitamin B12 also counteracted the increased expression of protein and mRNA contents of TNF-alpha and iNOS produced by nicotine.	Folic Acid	10-20	tumor necrosis factor	Rattus norvegicus	112-121
27832994-6	2016	Moreover, folic acid and vitamin B12 also counteracted the increased expression of protein and mRNA contents of TNF-alpha and iNOS produced by nicotine.	Folic Acid	10-20	nitric oxide synthase 2	Rattus norvegicus	126-130
27378204-2	2016	Analysis of cellular internalization revealed that folic acid conjugated minicells internalized through receptor mediated endocytosis in folate and PSMA receptor positive KB and LNCaP cells, respectively.	Folic Acid	51-61	folate hydrolase 1	Homo sapiens	148-152
27389146-0	2016	Folate-targeted amphiphilic cyclodextrin.siRNA nanoparticles for prostate cancer therapy exhibit PSMA mediated uptake, therapeutic gene silencing in vitro and prolonged circulation in vivo.	Folic Acid	0-6	folate hydrolase 1	Homo sapiens	97-101
27389146-1	2016	In this study, a folate targeted cyclodextrin (CD) nanoparticle was prepared by co-formulating CD.siRNA complexes with DSPE-PEG5000-folate to target the prostate specific membrane antigen (PSMA).	Folic Acid	17-23	folate hydrolase 1	Homo sapiens	153-187
27780269-0	2016	Comparative Assessment of Vitamin-B12, Folic Acid and Homocysteine Levels in Relation to p53 Expression in Megaloblastic Anemia.	Folic Acid	39-49	tumor protein p53	Homo sapiens	89-92
27760199-1	2016	The methylfolate trap, a metabolic blockage associated with anemia, neural tube defects, Alzheimer"s dementia, cardiovascular diseases, and cancer, was discovered in the 1960s, linking the metabolism of folate, vitamin B12, methionine and homocysteine.	Folic Acid	10-16	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	219-222
27154735-7	2016	In addition, 6 gene-gene interactions (P = 0.0001 to 0.001) and an ABCA4-folic acid consumption interaction (P &lt; 0.0001) were identified.	Folic Acid	73-83	ATP binding cassette subfamily A member 4	Homo sapiens	67-72
27387982-2	2016	PSMA participates in various biological functions depending on the substrate available in the particular tissue; in the brain, PSMA cleaves the abundant neuropeptide N-acetyl-aspartyl-glutamate to regulate release of key neurotransmitters, while intestinal PSMA cleaves polyglutamated peptides to supply dietary folate.	Folic Acid	312-318	folate hydrolase 1	Homo sapiens	0-4
27387982-2	2016	PSMA participates in various biological functions depending on the substrate available in the particular tissue; in the brain, PSMA cleaves the abundant neuropeptide N-acetyl-aspartyl-glutamate to regulate release of key neurotransmitters, while intestinal PSMA cleaves polyglutamated peptides to supply dietary folate.	Folic Acid	312-318	folate hydrolase 1	Homo sapiens	127-131
27387982-2	2016	PSMA participates in various biological functions depending on the substrate available in the particular tissue; in the brain, PSMA cleaves the abundant neuropeptide N-acetyl-aspartyl-glutamate to regulate release of key neurotransmitters, while intestinal PSMA cleaves polyglutamated peptides to supply dietary folate.	Folic Acid	312-318	folate hydrolase 1	Homo sapiens	127-131
27392941-5	2016	METHODS: We have synthesized folic acid (FA) armed mesoporous silica nanoparticles (MSN-FA-Q) loaded with quercetin and then characterized it by DLS, SEM, TEM and FTIR.	Folic Acid	29-39	moesin	Homo sapiens	84-87
27703674-11	2016	The logistic regression analysis revealed that the serum levels of folate and vitamin B12 were independent risk factors for epilepsy with secondary thrombosis [folate: odds ratio (OR)=0.635, P=0.038; vitamin B12: OR=0.418, P=0.042].	Folic Acid	67-73	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	208-211
27739310-7	2016	AIM: The aim of this study was to analyse the physiological role of GNMT and to examine in greater detail its connection with PC at different levels, including gene structure, gene expression, and metabolism, in which GNMT plays an important role, not only in controlling the methylation status of cells, but also the metabolism of folic acid and methionine.	Folic Acid	332-342	glycine N-methyltransferase	Homo sapiens	68-72
26508298-1	2016	BACKGROUND: This study is to examine the effects of folic acid supplementation on cognitive function in Chinese older adults with mild cognitive impairment who are unexposed to folic acid fortification and assess cognitive functioning in relation to folate, homocysteine, and vitamin B12 values at baseline.	Folic Acid	52-62	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	284-287
27739310-7	2016	AIM: The aim of this study was to analyse the physiological role of GNMT and to examine in greater detail its connection with PC at different levels, including gene structure, gene expression, and metabolism, in which GNMT plays an important role, not only in controlling the methylation status of cells, but also the metabolism of folic acid and methionine.	Folic Acid	332-342	glycine N-methyltransferase	Homo sapiens	218-222
27387868-1	2016	OBJECTIVE: The functional variant within the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene c.677C&gt;T, producing alterations in folate metabolism, has been associated with the risk of non-syndromic cleft lip with or without cleft palate (NSCL/P).	Folic Acid	69-75	nescient helix-loop-helix 1	Homo sapiens	247-251
26446020-4	2016	Moreover, a prominent negative correlation was found between the folate level in brain tissue and the gli2 methylation status (r = -0.41, P = 0.014), and gli2 hypermethylation increased the risk of spina bifida with an odds ratio of 12.45 (95 % confidence interval: 2.71-57.22, P = 0.001).	Folic Acid	65-71	GLI family zinc finger 2	Homo sapiens	102-106
26224648-8	2016	Folic acid dose-dependently stimulated methylation potential and DNMT activity, altered PS1 and APP promoter methylation, decreased PS1 and APP expression, and partially preserved cell viability.	Folic Acid	0-10	DNA methyltransferase (cytosine-5) 1	Mus musculus	65-69
27904616-0	2016	Effect of folic acid and metformin on insulin resistance and inflammatory factors of obese children and adolescents.	Folic Acid	10-20	insulin	Homo sapiens	38-45
27904616-7	2016	After folic acid and metformin administration, mean of Hcy, HOMA-IR, TNF-alpha, and IL-8 decreased significantly (P &lt; 0.05).	Folic Acid	6-16	tumor necrosis factor	Homo sapiens	69-78
27904616-7	2016	After folic acid and metformin administration, mean of Hcy, HOMA-IR, TNF-alpha, and IL-8 decreased significantly (P &lt; 0.05).	Folic Acid	6-16	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
27904616-8	2016	IL-6 decreased significantly after folic acid use (P &lt; 0.05).	Folic Acid	35-45	interleukin 6	Homo sapiens	0-4
27302066-1	2016	Our previous study suggested that ceramide synthase 6 (CerS6), an enzyme in sphingolipid biosynthesis, is regulated by p53: CerS6 was elevated in several cell lines in response to transient expression of p53 or in response to folate stress, which is known to activate p53.	Folic Acid	226-232	tumor protein p53	Homo sapiens	119-122
27302066-1	2016	Our previous study suggested that ceramide synthase 6 (CerS6), an enzyme in sphingolipid biosynthesis, is regulated by p53: CerS6 was elevated in several cell lines in response to transient expression of p53 or in response to folate stress, which is known to activate p53.	Folic Acid	226-232	tumor protein p53	Homo sapiens	204-207
27302066-1	2016	Our previous study suggested that ceramide synthase 6 (CerS6), an enzyme in sphingolipid biosynthesis, is regulated by p53: CerS6 was elevated in several cell lines in response to transient expression of p53 or in response to folate stress, which is known to activate p53.	Folic Acid	226-232	tumor protein p53	Homo sapiens	204-207
27890035-2	2016	The TNFa gene is subject of epigenetic regulation in which folate and homocysteine are important molecules because they participate in the methionine cycle where the most important methyl group donor (S-adenosylmethionine) is formed.	Folic Acid	59-65	tumor necrosis factor	Homo sapiens	4-8
27890035-3	2016	We investigated whether TNFa gene promoter methylation status in T1D patients was related to blood folate, homocysteine and TNF-alpha in a transversal case-control study.	Folic Acid	99-105	tumor necrosis factor	Homo sapiens	24-28
27488762-14	2016	The transcript level of cytosolic NADPH-producing gene involved in folate metabolism is down-regulated by DHFR inhibitors, which highlights the functional significance of DHFR in lipid biosynthesis.	Folic Acid	67-73	dihydrofolate reductase	Escherichia coli	106-110
27488762-14	2016	The transcript level of cytosolic NADPH-producing gene involved in folate metabolism is down-regulated by DHFR inhibitors, which highlights the functional significance of DHFR in lipid biosynthesis.	Folic Acid	67-73	dihydrofolate reductase	Escherichia coli	171-175
27562465-0	2016	Mechanistic target of rapamycin (mTOR) regulates trophoblast folate uptake by modulating the cell surface expression of FR-alpha and the RFC.	Folic Acid	61-67	mechanistic target of rapamycin kinase	Homo sapiens	0-31
27562465-0	2016	Mechanistic target of rapamycin (mTOR) regulates trophoblast folate uptake by modulating the cell surface expression of FR-alpha and the RFC.	Folic Acid	61-67	mechanistic target of rapamycin kinase	Homo sapiens	33-37
27562465-4	2016	We used cultured primary human trophoblast cells to test the hypothesis that mechanistic target of rapamycin complex 1 (mTORC1) and 2 (mTORC2) regulate folate transport by post-translational mechanisms.	Folic Acid	152-158	mechanistic target of rapamycin kinase	Homo sapiens	77-108
27562465-6	2016	Folate uptake stimulated by insulin + IGF-1 was mediated by mTORC2 but did not involve mTORC1.	Folic Acid	0-6	insulin	Homo sapiens	28-35
27562465-6	2016	Folate uptake stimulated by insulin + IGF-1 was mediated by mTORC2 but did not involve mTORC1.	Folic Acid	0-6	insulin like growth factor 1	Homo sapiens	38-43
27562465-10	2016	We propose that regulation of placental folate transport by mTOR signaling provide a direct link between placental function, gene methylation and fetal programming.	Folic Acid	40-46	mechanistic target of rapamycin kinase	Homo sapiens	60-64
27547186-11	2016	In conclusion, certain genetic polymorphisms related to the folate transport pathway, particularly COL18A1 rs2274808, SLC19A1 rs2838956, ABCB1 rs1045642, and ABCC5 rs3792585, were associated with an increased risk for ALL in Mexican children.	Folic Acid	60-66	ATP binding cassette subfamily B member 1	Homo sapiens	137-142
27384481-1	2016	Among ALDH isoforms, ALDH1L1 in the folate pathway showed highly increased expression in non-small-cell lung cancer cells (NSCLC).	Folic Acid	36-42	aldehyde dehydrogenase 1 family member L1	Homo sapiens	21-28
27283751-9	2016	Finally, the potential as antitumor therapy of our folate-decorated Cyt c-based NPs was confirmed with an in vivo brain tumor model.	Folic Acid	51-57	cytochrome c, somatic	Homo sapiens	68-73
27294849-2	2016	10-formyl-tetrahydrofolate-dehydrogenase (FDH) is a key regulator for folate availability and metabolic interconversion for the supply of 1-carbon groups.	Folic Acid	20-26	aldehyde dehydrogenase 1 family, member L1	Rattus norvegicus	42-45
27294849-10	2016	10-formyl-tetrahydrofolate-dehydrogenase (FDH) is a key regulator for folate availability and metabolic interconversion.	Folic Acid	20-26	aldehyde dehydrogenase 1 family, member L1	Rattus norvegicus	42-45
27113042-11	2016	These findings demonstrated that folic acid protected neuronal cells against Al-malt-induced apoptosis by preventing the downregulation of miR-19 and modulation of miR-19 related downstream PTEN/AKT/p53 pathway.	Folic Acid	33-43	AKT serine/threonine kinase 1	Homo sapiens	195-198
27113042-11	2016	These findings demonstrated that folic acid protected neuronal cells against Al-malt-induced apoptosis by preventing the downregulation of miR-19 and modulation of miR-19 related downstream PTEN/AKT/p53 pathway.	Folic Acid	33-43	tumor protein p53	Homo sapiens	199-202
27133904-0	2016	Folate deprivation modulates the expression of autophagy- and circadian-related genes in HT-22 hippocampal neuron cells through GR-mediated pathway.	Folic Acid	0-6	nuclear receptor subfamily 3, group C, member 1	Mus musculus	128-130
27188645-7	2016	At the cellular level the AuNPs-PEI-FA specifically delivered siRNA into LNCaP cells, a prostate cancer cell line overexpressing prostate specific membrane antigen (PSMA, exhibits a hydrolase enzymic activity with a folate substrate).	Folic Acid	216-222	folate hydrolase 1	Homo sapiens	129-163
27188645-7	2016	At the cellular level the AuNPs-PEI-FA specifically delivered siRNA into LNCaP cells, a prostate cancer cell line overexpressing prostate specific membrane antigen (PSMA, exhibits a hydrolase enzymic activity with a folate substrate).	Folic Acid	216-222	folate hydrolase 1	Homo sapiens	165-169
27282534-2	2016	In this study, two novel amphiphilic cyclodextrins (FCD-1 and FCD-2) conjugated with folate group to enable active targeting to folate positive breast tumors were introduced.	Folic Acid	85-91	FECD2	Homo sapiens	52-57
27282534-2	2016	In this study, two novel amphiphilic cyclodextrins (FCD-1 and FCD-2) conjugated with folate group to enable active targeting to folate positive breast tumors were introduced.	Folic Acid	85-91	FECD3	Homo sapiens	62-67
27470963-0	2016	[Preparation of folate-targeted magnetic nanocomposites loaded with TFPI-2 plasmid and cisplatin and evaluation of its targeting and inhibitory effect on nasopharyngeal carcinoma HNE-1 cells in vitro].	Folic Acid	16-22	tissue factor pathway inhibitor 2	Homo sapiens	68-74
27282534-2	2016	In this study, two novel amphiphilic cyclodextrins (FCD-1 and FCD-2) conjugated with folate group to enable active targeting to folate positive breast tumors were introduced.	Folic Acid	128-134	FECD2	Homo sapiens	52-57
27282534-2	2016	In this study, two novel amphiphilic cyclodextrins (FCD-1 and FCD-2) conjugated with folate group to enable active targeting to folate positive breast tumors were introduced.	Folic Acid	128-134	FECD3	Homo sapiens	62-67
27453780-0	2016	Effect of in ovo folic acid injection on hepatic IGF2 expression and embryo growth of broilers.	Folic Acid	17-27	insulin like growth factor 2	Gallus gallus	49-53
27453780-3	2016	The purpose of this study was to explore whether folic acid could regulate IGF2 expression via epigenetic mechanism and further promote embryonic growth of new-hatched broilers.	Folic Acid	49-59	insulin like growth factor 2	Gallus gallus	75-79
27453780-8	2016	RESULTS: Results have showed that IGF2 expression was up-regulated in 150 mug folic acid group (P &lt; 0.05) and other two dose of folic acid did not affect gene expression (P &gt; 0.05).	Folic Acid	78-88	insulin like growth factor 2	Gallus gallus	34-38
27453780-13	2016	CONCLUSION: In conclusion, our data have demonstrated that 150 mug folic acid injection on E11 could up-regulate IGF2 expression by modulating DNA hypomethylation and improving chromatin accessibility in the gene promoter region, and ulteriorly facilitate embryonic growth and organ development of broilers.	Folic Acid	67-77	insulin like growth factor 2	Gallus gallus	113-117
27470963-1	2016	OBJECTIVE: To prepare a novel folate-targeted magnetic nanocomposites loaded with tissue facor pathway inhibitor 2 (TFPI-2) and cisplatin (CDDP) and to investigate its targeting ability and anti-tumor effect on nasopharyngeal carcinoma HNE-1 cells in vitro.	Folic Acid	30-36	tissue factor pathway inhibitor 2	Homo sapiens	116-122
27470963-2	2016	METHODS: The copolymer folic acid-polyethylene glycol-polyethyleneimine (FA-PEG-PEI) was synthesized through amidation reaction, and then FA-PEG-PEI/ magnetic nanoparticles-CDDP/TFPI-2 (MNP-CDDP/TFPI-2) nanocomposites was obtained by electrostatic adsorption between TFPI-2 plasmid and magnetic nanoparticles loaded with CDDP (MNP-CDDP) with vortex FA-PEG-PEI.	Folic Acid	23-33	tissue factor pathway inhibitor 2	Homo sapiens	178-184
27470963-2	2016	METHODS: The copolymer folic acid-polyethylene glycol-polyethyleneimine (FA-PEG-PEI) was synthesized through amidation reaction, and then FA-PEG-PEI/ magnetic nanoparticles-CDDP/TFPI-2 (MNP-CDDP/TFPI-2) nanocomposites was obtained by electrostatic adsorption between TFPI-2 plasmid and magnetic nanoparticles loaded with CDDP (MNP-CDDP) with vortex FA-PEG-PEI.	Folic Acid	23-33	tissue factor pathway inhibitor 2	Homo sapiens	195-201
27470963-2	2016	METHODS: The copolymer folic acid-polyethylene glycol-polyethyleneimine (FA-PEG-PEI) was synthesized through amidation reaction, and then FA-PEG-PEI/ magnetic nanoparticles-CDDP/TFPI-2 (MNP-CDDP/TFPI-2) nanocomposites was obtained by electrostatic adsorption between TFPI-2 plasmid and magnetic nanoparticles loaded with CDDP (MNP-CDDP) with vortex FA-PEG-PEI.	Folic Acid	23-33	tissue factor pathway inhibitor 2	Homo sapiens	195-201
26853819-5	2016	In this overview, we summarize recent evidence that the enzyme MTHFD1 plays an essential role in FOCM in humans and in mice, and that it determines the partitioning of folate-activated one carbon units between the folate-dependent de novo thymidylate and homocysteine remethylation pathways through its regulated nuclear localization.	Folic Acid	168-174	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	63-69
26853819-6	2016	We demonstrate that impairments in MTHFD1 activity compromise both homocysteine remethylation and de novo thymidylate biosynthesis, and provide evidence that MTHFD1-associated disruptions in de novo thymidylate biosynthesis lead to genome instability that may underlie folate-associated immunodeficiency and birth defects.	Folic Acid	269-275	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	35-41
26853819-6	2016	We demonstrate that impairments in MTHFD1 activity compromise both homocysteine remethylation and de novo thymidylate biosynthesis, and provide evidence that MTHFD1-associated disruptions in de novo thymidylate biosynthesis lead to genome instability that may underlie folate-associated immunodeficiency and birth defects.	Folic Acid	269-275	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	158-164
26924399-4	2016	In the current study we found that expression of Mthfd1L, encoding a key component of mitochondrial folate one-carbon metabolism (FOCM), is significantly reduced in ct/ct embryos compared to a partially congenic wild-type strain.	Folic Acid	100-106	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like	Mus musculus	49-56
27131640-1	2016	The recent increase in the intake of folic acid by the general public through fortified foods and supplements, has raised safety concern based on early reports of adverse health outcome in elderly with low B12 status who took high doses of folic acid.	Folic Acid	37-47	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	206-209
27131640-1	2016	The recent increase in the intake of folic acid by the general public through fortified foods and supplements, has raised safety concern based on early reports of adverse health outcome in elderly with low B12 status who took high doses of folic acid.	Folic Acid	240-250	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	206-209
27131640-4	2016	Adverse clinical outcomes in association with high folate intake were also seen among elderly with low plasma B12 levels from the Framingham Original Cohort and in a study from Australia which combined three elderly cohorts.	Folic Acid	51-57	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	110-113
27163846-5	2016	RESULTS: Whole exome sequencing of DNA from a patient with severe combined immunodeficiency (SCID), megaloblastic anemia and hemolytic uremic syndrome identified mutations in the MTHFD1 gene, which encodes a trifunctional enzyme involved in interconversion of folate coenzyme derivatives.	Folic Acid	260-266	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	179-185
29336534-1	2016	Folic acid (FA)-gamma cyclodextrin (gamma CD)-C60 was synthesized in this study as a carrier for tumor-targeted drug delivery to enhance the anticancer effect of carboplatin (CBP).	Folic Acid	0-10	CREB binding protein	Homo sapiens	175-178
27221219-2	2016	The authors in this highlighted issue describe the synthesis and the photobiological characterizations of two photosensitizer (PS) conjugates based on beta-carboline derivatives covalently conjugated to folic acid (FA) coupled to bovine serum albumin (BSA) as a carrier system specifically targeting cancer cells overexpressing FA receptor alpha (FRalpha).	Folic Acid	203-213	albumin	Homo sapiens	237-250
26906511-0	2016	Folic Acid Attenuates Vascular Endothelial Cell Injury Caused by Hypoxia via the Inhibition of ERK1/2/NOX4/ROS Pathway.	Folic Acid	0-10	mitogen-activated protein kinase 3	Homo sapiens	95-101
26906511-9	2016	In addition, folic acid decreased protein expressions of NOX4 and p-ERK1/2, while it increased the protein expression of eNOS in HUVECs.	Folic Acid	13-23	mitogen-activated protein kinase 3	Homo sapiens	68-74
26906511-9	2016	In addition, folic acid decreased protein expressions of NOX4 and p-ERK1/2, while it increased the protein expression of eNOS in HUVECs.	Folic Acid	13-23	nitric oxide synthase 3	Homo sapiens	121-125
27183249-1	2016	We report the computational analysis, synthesis and characterization of folate functionalized poly(styrene-alt-maleic anhydride), PSMA for drug delivery purpose.	Folic Acid	72-78	folate hydrolase 1	Homo sapiens	130-134
27183249-3	2016	The computational results showed the bio-degradable linker 2, 4-diaminobutyric acid, DABA as a good candidate allowing flexibility of the folic acid group while maintaining the pH sensitivity of PSMA, used as a trigger for drug release.	Folic Acid	138-148	folate hydrolase 1	Homo sapiens	195-199
27453110-0	2016	[Relationship and interaction between folate and expression of methyl-CpG-binding protein 2 in cervical cancerization].	Folic Acid	38-44	methyl-CpG binding protein 2	Homo sapiens	63-91
27453110-1	2016	OBJECTIVE: To explore the interaction between folate and the expression of methyl-CpG-binding protein 2(MeCP2)in cervical cancerization.	Folic Acid	46-52	methyl-CpG binding protein 2	Homo sapiens	75-103
27453110-1	2016	OBJECTIVE: To explore the interaction between folate and the expression of methyl-CpG-binding protein 2(MeCP2)in cervical cancerization.	Folic Acid	46-52	methyl-CpG binding protein 2	Homo sapiens	104-109
27453110-8	2016	There were negative correlation between folate level and the expression level of MeCP2 protein(serum folate: r=-0.226, P=0.003; RBC folate: r=-0.164, P=0.004).	Folic Acid	40-46	methyl-CpG binding protein 2	Homo sapiens	81-86
27453110-10	2016	CONCLUSION: Folate deficiency and high expression of MeCP2 gene might increase the risk of cervical cancer and its precancerous lesions through interaction among serum folate deficiency, RBC folate deficiency, MeCP2 protein high expression and mRNA high expression in the progression of cervical cancerization.	Folic Acid	168-174	methyl-CpG binding protein 2	Homo sapiens	53-58
26853819-5	2016	In this overview, we summarize recent evidence that the enzyme MTHFD1 plays an essential role in FOCM in humans and in mice, and that it determines the partitioning of folate-activated one carbon units between the folate-dependent de novo thymidylate and homocysteine remethylation pathways through its regulated nuclear localization.	Folic Acid	214-220	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	63-69
28806886-6	2016	The CBS SNP at rs6586282 may infl uence anthropometric parameters, though only in case of low folate intake.	Folic Acid	94-100	cystathionine beta-synthase	Homo sapiens	4-7
27183616-4	2016	We demonstrate that physiological properdin, a positive regulator of complement alternative pathway activity, increases PGA formation when added to TRAP-stimulated blood.	Folic Acid	120-123	complement factor properdin	Homo sapiens	34-43
27183616-5	2016	All physiological properdin forms increase PGA formation, but properdin tetramers are the most efficient at increasing complement activity and PGA formation.	Folic Acid	43-46	complement factor properdin	Homo sapiens	18-27
27183616-5	2016	All physiological properdin forms increase PGA formation, but properdin tetramers are the most efficient at increasing complement activity and PGA formation.	Folic Acid	143-146	complement factor properdin	Homo sapiens	62-71
27183616-6	2016	Inhibition of endogenous properdin, either circulating in the blood or produced locally by leukocytes, impairs TRAP-mediated PGA formation to the same level as specific inhibition of either the alternative or classical pathway.	Folic Acid	125-128	complement factor properdin	Homo sapiens	25-34
27183616-7	2016	Additionally, blocking the interaction of C5a with its cellular receptor prevents properdin-mediated increases in PGA formation.	Folic Acid	114-117	complement C5a receptor 1	Homo sapiens	42-45
27183616-7	2016	Additionally, blocking the interaction of C5a with its cellular receptor prevents properdin-mediated increases in PGA formation.	Folic Acid	114-117	complement factor properdin	Homo sapiens	82-91
27183616-9	2016	Finally, we demonstrate that the effects of properdin on PGA formation are tightly regulated by Factor H.	Folic Acid	57-60	complement factor properdin	Homo sapiens	44-53
27183616-10	2016	Cumulatively, our data indicate that properdin enhances PGA formation via increased production of C5a, and that inhibition of properdin function has therapeutic potential to limit thromboinflammation in diseases characterized by increased PGA formation.	Folic Acid	56-59	complement factor properdin	Homo sapiens	37-46
27183616-10	2016	Cumulatively, our data indicate that properdin enhances PGA formation via increased production of C5a, and that inhibition of properdin function has therapeutic potential to limit thromboinflammation in diseases characterized by increased PGA formation.	Folic Acid	239-242	complement factor properdin	Homo sapiens	126-135
27129905-0	2016	Pharmacokinetics and Tissue Distribution of Folate-Decorated Human Serum Albumin Loaded With Nano-Hydroxycamptothecin for Tumor Targeting.	Folic Acid	44-50	albumin	Homo sapiens	73-80
26803590-4	2016	METHODS AND RESULTS: We explored the association between a MTHFD1 polymorphism (rs1076991 C &gt; T) and acute myocardial infarction (AMI), and potential effect modifications by folic acid/B12 and/or vitamin B6 treatment in suspected stable angina pectoris patients (n = 2381) participating in the randomized Western Norway B Vitamin Intervention Trial (WENBIT).	Folic Acid	177-187	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	59-65
26853484-6	2016	Long-term folate supplementation resulted in a significant decrease in serum insulin levels (-1.6 +- 6.2 versus +2.6 +- 6.9 muIU/mL, P = 0.018) and homeostatic model assessment-beta cell function (HOMA-B) (-13.0 +- 39.0 versus +11.2 +- 42.3, P = 0.028) compared with the placebo.	Folic Acid	10-16	insulin	Homo sapiens	77-84
26906511-14	2016	Taken together, the results suggested that hypoxia decreased the cell survival rate and induced apoptosis via ERK1/2/NOX4/ROS pathway, which could be the target of folic acid in protecting the HUVECs from injury caused by hypoxia.	Folic Acid	164-174	mitogen-activated protein kinase 3	Homo sapiens	110-116
27313708-0	2016	Low folate levels are associated with methylation-mediated transcriptional repression of miR-203 and miR-375 during cervical carcinogenesis.	Folic Acid	4-10	microRNA 375	Homo sapiens	101-108
27313708-1	2016	The aim of the present study was to investigate the correlation between a lack of folic acid and the abnormal expression of microRNA (miR)-203 and miR-375 in cervical cancer.	Folic Acid	82-92	microRNA 375	Homo sapiens	147-154
27313708-8	2016	In CaSki cells, as the concentration of folic acid increased, the positive rate of DNA methylation of miR-203 and miR-375 decreased, while the expression levels of miR-203 and miR-375 demonstrated a gradual increase, which indicated that the latter two parameters were negatively correlated (P&lt;0.05).	Folic Acid	40-50	microRNA 375	Homo sapiens	114-121
27313708-8	2016	In CaSki cells, as the concentration of folic acid increased, the positive rate of DNA methylation of miR-203 and miR-375 decreased, while the expression levels of miR-203 and miR-375 demonstrated a gradual increase, which indicated that the latter two parameters were negatively correlated (P&lt;0.05).	Folic Acid	40-50	microRNA 375	Homo sapiens	176-183
27313708-11	2016	Therefore, reduced levels of folic acid, leading to increased methylation of miR-203 and miR-375, may be significant events during cervical carcinogenesis.	Folic Acid	29-39	microRNA 375	Homo sapiens	89-96
27346115-0	2016	[Interaction between folate and the expression of human papillomavirus 16 E6/E7 mRNA in the progression of cervix carcinogenesis].	Folic Acid	21-27	protein E6*;transforming protein E6	Human papillomavirus type 16	74-76
27274503-0	2016	Effect of folic acid on homocysteine and insulin resistance of overweight and obese children and adolescents.	Folic Acid	10-20	insulin	Homo sapiens	41-48
27274503-1	2016	BACKGROUND: Considering the increasing trend of childhood obesity and subsequent burden of the disease in Iran and other countries and importance of early life intervention for achieving sustained effect on health of children and adolescents, this study aimed to investigate the effect of two different dose of folic acid on homocysteine (Hcy) level and insulin resistance of obese children.	Folic Acid	311-321	insulin	Homo sapiens	354-361
27274503-7	2016	After folic acid administration, mean of Hcy, insulin resistance and insulin decreased significantly in two groups which folic acid administrated with two different doses (P &lt; 0.05).	Folic Acid	121-131	insulin	Homo sapiens	46-76
27274503-11	2016	CONCLUSION: The findings of current trial showed that folic acid in two studied doses could be a safe and effective supplement for obese children to reduce Hcy level and insulin resistance, which consequently could prevent obesity-related complications including cardiovascular and metabolic disorders.	Folic Acid	54-64	insulin	Homo sapiens	170-177
26961134-8	2016	Four DM CpGs identified by SNPs in MTRR, MTHFR, and FTHFD were significantly associated with alcohol consumption and/or breast folate.	Folic Acid	127-133	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	35-39
26961134-8	2016	Four DM CpGs identified by SNPs in MTRR, MTHFR, and FTHFD were significantly associated with alcohol consumption and/or breast folate.	Folic Acid	127-133	aldehyde dehydrogenase 1 family member L1	Homo sapiens	52-57
26477310-0	2016	Systematic integration of molecular profiles identifies miR-22 as a regulator of lipid and folate metabolism in breast cancer cells.	Folic Acid	91-97	microRNA 22	Homo sapiens	56-62
26784656-7	2016	Dietary intake of folate appears to confer protection against breast cancer through its modulating effects on ER and PR expression and methylation of EC-SOD and BRCA1.	Folic Acid	18-24	superoxide dismutase 3	Homo sapiens	150-156
27129905-1	2016	The goal of this work is to develop the method of preparing folate (FA)-decorated human serum albumin (HSA) loaded with nano-hydroxycamptothecin (nHCPT) nanoparticles (NPs) (FA-HSA-nHCPT-NPs) and to explore its antitumor activity in vivo and in vitro.	Folic Acid	60-66	albumin	Homo sapiens	94-101
27386651-12	2016	Compared with the model group, mRNA expression of DNMT1 in Ang II induced VSMCs was obviously enhanced in the folate group and the PQR group (P &lt; 0.01).	Folic Acid	110-116	angiotensinogen	Homo sapiens	59-65
26853484-8	2016	CONCLUSIONS: Taken together, folate supplementation (5 mg/d) for 6 mo among women with CIN1 resulted in its regression as well as led to decreased serum insulin, HOMA-B, plasma MDA and increased plasma GSH levels; however, it did not affect other metabolic profiles.	Folic Acid	29-35	insulin	Homo sapiens	153-160
26317691-3	2016	Compared to patients with AITD and controls, the HLA-DRB1*03 (pc =0.001), *04 (pc&lt;0.001), -DQA1*03 (pc&lt;0.001), and -DQB1*02 (pc =0.001) alleles were increased in patients with PGA.	Folic Acid	182-185	major histocompatibility complex, class II, DR beta 1	Homo sapiens	49-57
26989972-6	2016	In contrast, female pups from folic acid-supplemented dams were 5% lighter than those from control-fed dams and had lower proopiomelanocortin (Pomc) (42%), Lepr (32%), and Agrp (13%), but higher neuropeptide Y (Npy) (18%) mRNA expression.	Folic Acid	30-40	neuropeptide Y	Rattus norvegicus	195-209
26989972-6	2016	In contrast, female pups from folic acid-supplemented dams were 5% lighter than those from control-fed dams and had lower proopiomelanocortin (Pomc) (42%), Lepr (32%), and Agrp (13%), but higher neuropeptide Y (Npy) (18%) mRNA expression.	Folic Acid	30-40	neuropeptide Y	Rattus norvegicus	211-214
27012626-7	2016	Splenocytes from mice on high folic acid diet produced less interleukin (IL)-10 when stimulated with lipopolysaccharide (P&lt;.05).	Folic Acid	30-40	interleukin 10	Mus musculus	60-79
27012626-8	2016	The difference in NK cell cytotoxicity between dietary groups was abolished when the splenocytes were supplemented with exogenous IL-10 prior to assessment of the NK cytotoxicity, suggesting that the reduced NK cell cytotoxicity of the high folic acid group was at least partially due to reduced IL-10 production.	Folic Acid	241-251	interleukin 10	Mus musculus	130-135
26776679-3	2016	In order to better understand the regulation and role of NF-kappaB in acute kidney injury we explored the expression of NF-kappaB-related genes in experimental acute kidney injury induced by a folic acid overdose.	Folic Acid	193-203	nuclear factor kappa B subunit 1	Homo sapiens	120-129
26657220-11	2016	CONCLUSION: The Tc-Bombesin-folate heterobivalent radiopharmaceutical significantly enhances in-vivo tumour uptake because of the concomitant interaction with FRalpha and GRPR.	Folic Acid	27-34	gastrin releasing peptide receptor	Homo sapiens	171-175
26392017-1	2016	OBJECTIVE: Prenatal folic acid supplementation or maternal folate sufficiency may protect the offspring from obesity and insulin resistance.	Folic Acid	20-30	insulin	Homo sapiens	121-128
27398055-3	2016	Intermittent concerns have been raised concerning possible deleterious effects of folate supplementation, including the masking of symptoms of vitamin B12 deficiency and an association with cancer, especially colorectal cancer.	Folic Acid	82-88	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	151-154
27904562-4	2016	The deficient levels of folic acid and vitamin B12 defined as &lt;10th percentile of folic acid and vitamin B12 level and hyper-Hcys was defined as &gt;90th percentile of homocysteine of control group.	Folic Acid	24-34	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	108-111
26804918-0	2016	The PGC-1alpha/ERRalpha Axis Represses One-Carbon Metabolism and Promotes Sensitivity to Anti-folate Therapy in Breast Cancer.	Folic Acid	94-100	PPARG coactivator 1 alpha	Homo sapiens	4-14
26804918-0	2016	The PGC-1alpha/ERRalpha Axis Represses One-Carbon Metabolism and Promotes Sensitivity to Anti-folate Therapy in Breast Cancer.	Folic Acid	94-100	estrogen related receptor alpha	Homo sapiens	15-23
26804918-5	2016	These data implicate the PGC-1alpha/ERRalpha axis as a core regulatory node of folate cycle metabolism and further suggest that activators of AMPK could be used to modulate this pathway in cancer.	Folic Acid	79-85	PPARG coactivator 1 alpha	Homo sapiens	25-35
26804918-5	2016	These data implicate the PGC-1alpha/ERRalpha axis as a core regulatory node of folate cycle metabolism and further suggest that activators of AMPK could be used to modulate this pathway in cancer.	Folic Acid	79-85	estrogen related receptor alpha	Homo sapiens	36-44
26655793-0	2016	Reversing of multidrug resistance breast cancer by co-delivery of P-gp siRNA and doxorubicin via folic acid-modified core-shell nanomicelles.	Folic Acid	97-107	ATP binding cassette subfamily B member 1	Homo sapiens	66-70
26634288-7	2016	In vitro, all folate derivatives showed high binding affinity to the FR-alpha (IC50 = 1.4-2.2 nM).	Folic Acid	14-20	rabaptin, RAB GTPase binding effector protein 2	Mus musculus	69-77
27222061-0	2016	Tanshinone IIA Protects Against Folic Acid-Induced Acute Kidney Injury.	Folic Acid	32-42	ATPase, class II, type 9A	Mus musculus	11-14
27222061-4	2016	Here, we show for the first time that systemic administration of Tanshinone IIA can lead to improved kidney function in folic acid-induced kidney injury mice.	Folic Acid	120-130	ATPase, class II, type 9A	Mus musculus	76-79
26540672-4	2016	The aim of the investigation was to replicate previous studies reporting evidence of association between polymorphisms of folate related genes and the occurrence of non-syndromic cleft lip with or without cleft palate (NSCL/P), using three independent samples of different ancestry: from Tibet, Bangladesh and Iran, respectively.	Folic Acid	122-128	nescient helix-loop-helix 1	Homo sapiens	219-223
26599622-0	2016	A surface charge-switchable and folate modified system for co-delivery of proapoptosis peptide and p53 plasmid in cancer therapy.	Folic Acid	32-38	tumor protein p53	Homo sapiens	99-102
26599622-4	2016	After the accumulation of the FK/p53/PEG-PLL(DA) complexes in tumor sites, tumor-acidity-triggered charge switch led to the detachment of PEG-PLL(DA) from the FK/p53 complexes, and resulted in efficient tumor cell entry by folate-mediated uptake and electrostatic attraction.	Folic Acid	223-229	tumor protein p53	Homo sapiens	33-36
26599622-4	2016	After the accumulation of the FK/p53/PEG-PLL(DA) complexes in tumor sites, tumor-acidity-triggered charge switch led to the detachment of PEG-PLL(DA) from the FK/p53 complexes, and resulted in efficient tumor cell entry by folate-mediated uptake and electrostatic attraction.	Folic Acid	223-229	tumor protein p53	Homo sapiens	162-165
26715308-4	2016	Fol-PalphaC (G4, average degree of substitution of alpha-cyclodextrin (DSC) 2.9, average degree of substitution of folate-PEG (DSF) 2)/siRNA complex had the prominent RNAi effect through adequate physicochemical properties, FR-alpha-mediated endocytosis, efficient endosomal escape, and siRNA delivery to cytoplasm with negligible cytotoxicity.	Folic Acid	115-121	rabaptin, RAB GTPase binding effector protein 2	Mus musculus	224-232
26974319-0	2016	Folic Acid Represses Hypoxia-Induced Inflammation in THP-1 Cells through Inhibition of the PI3K/Akt/HIF-1alpha Pathway.	Folic Acid	0-10	AKT serine/threonine kinase 1	Homo sapiens	96-99
26974319-0	2016	Folic Acid Represses Hypoxia-Induced Inflammation in THP-1 Cells through Inhibition of the PI3K/Akt/HIF-1alpha Pathway.	Folic Acid	0-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	100-110
26974319-6	2016	Pretreating THP-1 cells with folic acid attenuated hypoxia-induced inflammatory responses, including a decrease in protein and mRNA levels of interleukin (IL)-1beta and tumor necrosis factor-alpha (TNF-alpha), coupled with increased levels of IL-10.	Folic Acid	29-39	interleukin 1 beta	Homo sapiens	142-164
26974319-6	2016	Pretreating THP-1 cells with folic acid attenuated hypoxia-induced inflammatory responses, including a decrease in protein and mRNA levels of interleukin (IL)-1beta and tumor necrosis factor-alpha (TNF-alpha), coupled with increased levels of IL-10.	Folic Acid	29-39	tumor necrosis factor	Homo sapiens	169-196
26974319-6	2016	Pretreating THP-1 cells with folic acid attenuated hypoxia-induced inflammatory responses, including a decrease in protein and mRNA levels of interleukin (IL)-1beta and tumor necrosis factor-alpha (TNF-alpha), coupled with increased levels of IL-10.	Folic Acid	29-39	tumor necrosis factor	Homo sapiens	198-207
26974319-7	2016	Folic acid also reduced hypoxia-induced Akt phosphorylation and decreased nuclear accumulation of HIF-1alpha protein.	Folic Acid	0-10	AKT serine/threonine kinase 1	Homo sapiens	40-43
26974319-7	2016	Folic acid also reduced hypoxia-induced Akt phosphorylation and decreased nuclear accumulation of HIF-1alpha protein.	Folic Acid	0-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	98-108
26974319-9	2016	We also found that insulin (an Akt activator) and dimethyloxallyl glycine (DMOG, a HIF-1alpha activator) induced over-expression of inflammatory cytokines, which could be blocked by folic acid.	Folic Acid	182-192	insulin	Homo sapiens	19-26
26974319-9	2016	We also found that insulin (an Akt activator) and dimethyloxallyl glycine (DMOG, a HIF-1alpha activator) induced over-expression of inflammatory cytokines, which could be blocked by folic acid.	Folic Acid	182-192	AKT serine/threonine kinase 1	Homo sapiens	31-34
26974319-9	2016	We also found that insulin (an Akt activator) and dimethyloxallyl glycine (DMOG, a HIF-1alpha activator) induced over-expression of inflammatory cytokines, which could be blocked by folic acid.	Folic Acid	182-192	hypoxia inducible factor 1 subunit alpha	Homo sapiens	83-93
26974319-10	2016	Taken together, these findings demonstrate how folic acid attenuates the hypoxia-induced inflammatory responses of THP-1 cells through inhibition of the PI3K/Akt/HIF-1alpha pathway.	Folic Acid	47-57	AKT serine/threonine kinase 1	Homo sapiens	158-161
26974319-10	2016	Taken together, these findings demonstrate how folic acid attenuates the hypoxia-induced inflammatory responses of THP-1 cells through inhibition of the PI3K/Akt/HIF-1alpha pathway.	Folic Acid	47-57	hypoxia inducible factor 1 subunit alpha	Homo sapiens	162-172
27042054-0	2016	Insights into the therapeutic potential of hypoxia-inducible factor-1alpha small interfering RNA in malignant melanoma delivered via folate-decorated cationic liposomes.	Folic Acid	133-139	hypoxia inducible factor 1 subunit alpha	Homo sapiens	43-74
27042054-3	2016	This article aimed to develop folate-decorated cationic liposomes (fc-LPs) for hypoxia-inducible factor-1alpha (HIF-1alpha) small interfering (siRNA) delivery, and to evaluate the potential of such siRNA/liposome complexes in MM therapy.	Folic Acid	30-36	hypoxia inducible factor 1 subunit alpha	Homo sapiens	79-110
27042054-3	2016	This article aimed to develop folate-decorated cationic liposomes (fc-LPs) for hypoxia-inducible factor-1alpha (HIF-1alpha) small interfering (siRNA) delivery, and to evaluate the potential of such siRNA/liposome complexes in MM therapy.	Folic Acid	30-36	hypoxia inducible factor 1 subunit alpha	Homo sapiens	112-122
26586196-7	2016	The splenic expression levels of IL-2 and IL-4 were up-regulated, whereas that of IL-6 was down-regulated, in the 100- and 150-microg folic acid treatment groups.	Folic Acid	134-144	interleukin 2	Homo sapiens	33-37
26586196-7	2016	The splenic expression levels of IL-2 and IL-4 were up-regulated, whereas that of IL-6 was down-regulated, in the 100- and 150-microg folic acid treatment groups.	Folic Acid	134-144	interleukin 4	Homo sapiens	42-46
26586196-7	2016	The splenic expression levels of IL-2 and IL-4 were up-regulated, whereas that of IL-6 was down-regulated, in the 100- and 150-microg folic acid treatment groups.	Folic Acid	134-144	interleukin 6	Homo sapiens	82-86
26586196-8	2016	In addition, histone methylation in IL-2 and IL-4 promoters exhibited an enrichment of H3K4m2 but a loss of H3K9me2 with the increased amount of folic acid additive.	Folic Acid	145-155	interleukin 2	Homo sapiens	36-40
26586196-8	2016	In addition, histone methylation in IL-2 and IL-4 promoters exhibited an enrichment of H3K4m2 but a loss of H3K9me2 with the increased amount of folic acid additive.	Folic Acid	145-155	interleukin 4	Homo sapiens	45-49
26586196-9	2016	In contrast, a decrease in H3K4m2 and an increase in H3K9me2 were observed in the IL-6 promoter in folic acid treatments.	Folic Acid	99-109	interleukin 6	Homo sapiens	82-86
26586196-10	2016	Furthermore, in ovo, the 150-microg folic acid injection improved the chromatin tightness of the IL-2 and IL-4 promoter regions.	Folic Acid	36-46	interleukin 2	Homo sapiens	97-101
26586196-10	2016	Furthermore, in ovo, the 150-microg folic acid injection improved the chromatin tightness of the IL-2 and IL-4 promoter regions.	Folic Acid	36-46	interleukin 4	Homo sapiens	106-110
26311115-4	2016	Folic acid-induced acute kidney injury increased calvaria FGF23 mRNA and serum FGF23 and parathyroid hormone (PTH) levels at 6 h. The FGFR1 receptor inhibitor PD173074 prevented the folic acid-induced increase in both FGF23 mRNA and serum levels but had no effect on serum PTH levels.	Folic Acid	0-10	parathyroid hormone	Rattus norvegicus	89-108
26795251-5	2016	Furthermore, we have demonstrated differential folate- and riboflavin-derivative reactivity by a diverse population of "atypical" TRAV1-2(-) MR1-restricted T cells.	Folic Acid	47-53	major histocompatibility complex, class I-related	Homo sapiens	141-144
26637016-8	2016	A two-folate, one-tetramer complex results in the loss of enzyme activity where two symmetry-related K32 residues in the protein are cross-linked to the carboxylates of two bound folates.	Folic Acid	6-12	keratin 32	Homo sapiens	101-104
26637016-8	2016	A two-folate, one-tetramer complex results in the loss of enzyme activity where two symmetry-related K32 residues in the protein are cross-linked to the carboxylates of two bound folates.	Folic Acid	179-186	keratin 32	Homo sapiens	101-104
26392017-1	2016	OBJECTIVE: Prenatal folic acid supplementation or maternal folate sufficiency may protect the offspring from obesity and insulin resistance.	Folic Acid	59-65	insulin	Homo sapiens	121-128
26392017-2	2016	This study aims to summarize the findings of association between prenatal folic acid supplementation/maternal folate sufficiency and obesity/insulin resistance in the offspring.	Folic Acid	74-84	insulin	Homo sapiens	141-148
26392017-2	2016	This study aims to summarize the findings of association between prenatal folic acid supplementation/maternal folate sufficiency and obesity/insulin resistance in the offspring.	Folic Acid	110-116	insulin	Homo sapiens	141-148
27707659-1	2016	BACKGROUND: Methylenetetrahydrofolate dehydrogenase (MTHFD1) deficiency has recently been reported to cause a folate-responsive syndrome displaying a phenotype that includes megaloblastic anemia and severe combined immunodeficiency.	Folic Acid	31-37	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	53-59
28018922-10	2016	The gene expression of TGF-beta increased in cases that had received folic acid at two and five months, and VEGF decreased in the CFA5 and DFA5 groups.	Folic Acid	69-79	transforming growth factor beta 1	Homo sapiens	23-31
26414244-0	2015	Folic Acid Promotes Recycling of Tetrahydrobiopterin and Protects Against Hypoxia-Induced Pulmonary Hypertension by Recoupling Endothelial Nitric Oxide Synthase.	Folic Acid	0-10	nitric oxide synthase 3	Homo sapiens	127-160
27398438-0	2016	Cancer Cell Targeting Using Folic Acid/Anti-HER2 Antibody Conjugated Fluorescent CdSe/CdS/ZnS-Mercaptopropionic Acid and CdTe-Mercaptosuccinic Acid Quantum Dots.	Folic Acid	28-38	erb-b2 receptor tyrosine kinase 2	Homo sapiens	44-48
27738387-6	2016	TNF-alpha and IL-1beta, as well as iNOS dependent NO production, resulted significantly inhibited by folic acid pretreatment in LPS-activated BV-2 cells.	Folic Acid	101-111	tumor necrosis factor	Mus musculus	0-9
27738387-6	2016	TNF-alpha and IL-1beta, as well as iNOS dependent NO production, resulted significantly inhibited by folic acid pretreatment in LPS-activated BV-2 cells.	Folic Acid	101-111	interleukin 1 beta	Mus musculus	14-22
27738387-6	2016	TNF-alpha and IL-1beta, as well as iNOS dependent NO production, resulted significantly inhibited by folic acid pretreatment in LPS-activated BV-2 cells.	Folic Acid	101-111	nitric oxide synthase 2, inducible	Mus musculus	35-39
27738387-7	2016	We also observed that folic acid dose-dependently upregulated both SOCS1 and SOCS3 expression in BV-2 cells, leading to an increased expression of the anti-inflammatory cytokine IL-10.	Folic Acid	22-32	interleukin 10	Mus musculus	178-183
27738387-8	2016	Finally, p-IkappaBalpha, which indirectly reflects NF-kappaB complex activation, and JNK phosphorylation resulted dose-dependently downregulated by folic acid pretreatment of LPS-activated cells, whereas p38 MAPK phosphorylation resulted significantly upregulated by folic acid treatment.	Folic Acid	148-158	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	51-60
25973643-7	2016	Moreover, folic acid in combination with vitamin B12 also attenuated the nicotine-induced changes in markers of oxidative stress (17-88% recovery), TNF-alpha (40-99% recovery), and IL-6 level (47-65% recovery), CRP level (59-73% recovery), expression of NF-kappaB and caspase-3, and apoptosis in pancreatic islet cells.	Folic Acid	10-20	tumor necrosis factor	Rattus norvegicus	148-157
25973643-7	2016	Moreover, folic acid in combination with vitamin B12 also attenuated the nicotine-induced changes in markers of oxidative stress (17-88% recovery), TNF-alpha (40-99% recovery), and IL-6 level (47-65% recovery), CRP level (59-73% recovery), expression of NF-kappaB and caspase-3, and apoptosis in pancreatic islet cells.	Folic Acid	10-20	interleukin 6	Rattus norvegicus	181-185
25973643-7	2016	Moreover, folic acid in combination with vitamin B12 also attenuated the nicotine-induced changes in markers of oxidative stress (17-88% recovery), TNF-alpha (40-99% recovery), and IL-6 level (47-65% recovery), CRP level (59-73% recovery), expression of NF-kappaB and caspase-3, and apoptosis in pancreatic islet cells.	Folic Acid	10-20	C-reactive protein	Rattus norvegicus	211-214
27905385-6	2016	RESULTS: The risk group which was characterized by the presence of risk variants of rs1801131 and rs1801133 polymorphisms, changes in the parameters of the folate cycle (the decrease in B12 concentration (&lt;=500 pg/ml)) in the combination with hyperhomocysteinemia (&gt;=13 mcmol/L) was identified.	Folic Acid	156-162	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	186-189
26386249-6	2015	In the case group, the folate levels were positively related with vitamin B12 levels (r = 0.54; p &lt; 0.001) and negatively correlated with total homocysteine levels (r = -0.19; p = 0.04).	Folic Acid	23-29	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	74-77
26400185-0	2015	Folic acid supplementation during high-fat diet feeding restores AMPK activation via an AMP-LKB1-dependent mechanism.	Folic Acid	0-10	serine/threonine kinase 11	Mus musculus	92-96
26400185-8	2015	Activation of AMPK by folic acid was mediated through an elevation of its allosteric activator AMP and activation of its upstream kinase, namely, liver kinase B1 (LKB1) in the liver.	Folic Acid	22-32	serine/threonine kinase 11	Mus musculus	146-161
26400185-8	2015	Activation of AMPK by folic acid was mediated through an elevation of its allosteric activator AMP and activation of its upstream kinase, namely, liver kinase B1 (LKB1) in the liver.	Folic Acid	22-32	serine/threonine kinase 11	Mus musculus	163-167
26492244-0	2015	Folic Acid Inhibits Amyloid beta-Peptide Production through Modulating DNA Methyltransferase Activity in N2a-APP Cells.	Folic Acid	0-10	DNA methyltransferase (cytosine-5) 1	Mus musculus	71-92
26226119-1	2015	PURPOSE: The objective of the study was to determine the incidence of vitamin B12 deficiency in patients under long-term treatment for phenylketonuria (PKU) and hyperphenylalaninemia (HPA), as well as its associations with B12 vitamin parameters (holotranscobalamin - active vitamin B12, serum folate, total plasma homocysteine, and plasma methylmalonic acid concentration).	Folic Acid	294-300	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	78-81
25428700-1	2015	Methylenetetrahydrofolate reductase (MTHFR), the key enzyme of the folate metabolic pathway, has been reported to be five times more active in the testicles compared to other organs in adult mice.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Mus musculus	37-42
26471812-6	2015	This variant exhibited higher affinity toward FPG compared with wild GCPII (-2.06 vs. -1.69); and positive correlation was observed between the P160S variant and circulating folate (r = 0.60).	Folic Acid	174-180	folate hydrolase 1	Homo sapiens	69-74
26492244-3	2015	We hypothesized that folic acid supplementation modulates DNA methyltransferase (DNMT) activity and may alter amyloid beta-peptide (Abeta) production in AD.	Folic Acid	21-31	DNA methyltransferase (cytosine-5) 1	Mus musculus	58-79
26492244-3	2015	We hypothesized that folic acid supplementation modulates DNA methyltransferase (DNMT) activity and may alter amyloid beta-peptide (Abeta) production in AD.	Folic Acid	21-31	DNA methyltransferase (cytosine-5) 1	Mus musculus	81-85
26235956-1	2015	The enzyme methylenetetrahydrofolate-reductase (MTHFR) is part of the homocysteine and folate metabolic pathways.	Folic Acid	30-36	methylenetetrahydrofolate reductase	Mus musculus	48-53
26288086-1	2015	Dihydropteroate synthase is a key enzyme in folate biosynthesis and is the target of the sulfonamide class of antimicrobials.	Folic Acid	44-50	AT695_RS00195	Staphylococcus aureus	0-24
26319423-8	2015	CONCLUSION: Intervention with B12 and folic acid is effective in reducing Hcy, PAI 1, fibrinogen levels and increasing NO levels at 1yr as compared to control arm and reducing the incidence of thrombosis at 2years of stay at HAA.	Folic Acid	38-48	fibrinogen beta chain	Homo sapiens	86-96
26195551-4	2015	Our previous study showed that PGA activates the human macrophage cell line THP-1 and human dendritic cells, resulting in the production of the proinflammatory cytokine interleukin-1beta (IL-1beta) (M. H. Cho et al., Infect Immun 78:387-392, 2010, http://dx.doi.org/10.1128/IAI.00956-09).	Folic Acid	31-34	GLI family zinc finger 2	Homo sapiens	76-81
26195551-4	2015	Our previous study showed that PGA activates the human macrophage cell line THP-1 and human dendritic cells, resulting in the production of the proinflammatory cytokine interleukin-1beta (IL-1beta) (M. H. Cho et al., Infect Immun 78:387-392, 2010, http://dx.doi.org/10.1128/IAI.00956-09).	Folic Acid	31-34	interleukin 1 beta	Homo sapiens	169-186
26195551-4	2015	Our previous study showed that PGA activates the human macrophage cell line THP-1 and human dendritic cells, resulting in the production of the proinflammatory cytokine interleukin-1beta (IL-1beta) (M. H. Cho et al., Infect Immun 78:387-392, 2010, http://dx.doi.org/10.1128/IAI.00956-09).	Folic Acid	31-34	interleukin 1 beta	Homo sapiens	188-196
26195551-7	2015	PGA stimulated Toll-like receptor 2 (TLR2) but not TLR4 in Chinese hamster ovary cells expressing either TLR2 or TLR4.	Folic Acid	0-3	Tlr2	Cricetulus griseus	15-35
26195551-7	2015	PGA stimulated Toll-like receptor 2 (TLR2) but not TLR4 in Chinese hamster ovary cells expressing either TLR2 or TLR4.	Folic Acid	0-3	Tlr2	Cricetulus griseus	37-41
26195551-7	2015	PGA stimulated Toll-like receptor 2 (TLR2) but not TLR4 in Chinese hamster ovary cells expressing either TLR2 or TLR4.	Folic Acid	0-3	Tlr2	Cricetulus griseus	105-109
26195551-12	2015	These results suggest that immune responses induced by PGA occur via TLR2, TLR6, CD14, and MyD88 through activation of MAP kinase and NF-kappaB pathways.	Folic Acid	55-58	Tlr2	Cricetulus griseus	69-73
26310574-8	2015	In addition, western blot analysis revealed that the expression levels of the muscle-specific marker, myosin heavy chain (MyHC), as well as those of the myogenic regulatory factors (MRFs), MyoD and myogenin, were increased in the folic acid-treated myotubes during myogenic differentiation.	Folic Acid	230-240	myosin heavy chain, cardiac muscle complex	Mus musculus	102-120
26310574-8	2015	In addition, western blot analysis revealed that the expression levels of the muscle-specific marker, myosin heavy chain (MyHC), as well as those of the myogenic regulatory factors (MRFs), MyoD and myogenin, were increased in the folic acid-treated myotubes during myogenic differentiation.	Folic Acid	230-240	myosin heavy chain, cardiac muscle complex	Mus musculus	122-126
26310574-9	2015	Folic acid also promoted the activation of the Akt pathway, and this effect was inhibited by treatment of the C2C12 cells with LY294002 (Akt inhibitor).	Folic Acid	0-10	thymoma viral proto-oncogene 1	Mus musculus	47-50
26310574-9	2015	Folic acid also promoted the activation of the Akt pathway, and this effect was inhibited by treatment of the C2C12 cells with LY294002 (Akt inhibitor).	Folic Acid	0-10	thymoma viral proto-oncogene 1	Mus musculus	137-140
26310574-10	2015	Blocking of the Akt pathway with a specific inhibitor revealed that it was necessary for mediating the stimulatory effects of folic acid on muscle cell differentiation and fusion.	Folic Acid	126-136	thymoma viral proto-oncogene 1	Mus musculus	16-19
26310574-11	2015	Taken together, our data suggest that folic acid promotes the differentiation of C2C12 cells through the activation of the Akt pathway.	Folic Acid	38-48	thymoma viral proto-oncogene 1	Mus musculus	123-126
26192119-4	2015	MALDI-TOF MS fingerprinting revealed that this MNSFbeta adduct consists of an 8.5 kDa MNSFbeta and 10-formyltetrahydrofolate dehydrogenase (FDH), an abundant enzyme of folate metabolism.	Folic Acid	118-124	Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived)	Mus musculus	47-55
26299783-2	2015	Folate deficiency has been associated with placenta-related pregnancy complications, as have SNP in genes of the folate-dependent enzymes, methionine synthase (MTR) and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1).	Folic Acid	113-119	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	169-210
26299783-2	2015	Folate deficiency has been associated with placenta-related pregnancy complications, as have SNP in genes of the folate-dependent enzymes, methionine synthase (MTR) and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1).	Folic Acid	113-119	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	212-218
26343515-0	2015	Polymorphisms in MTHFD1 Gene and Susceptibility to Neural Tube Defects: A Case-Control Study in a Chinese Han Population with Relatively Low Folate Levels.	Folic Acid	141-147	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	17-23
26337056-11	2015	Each of four gene polymorphisms (MTHTR C677T, MTHFR A1298C, MTR A2756G and MTRR A66G) combined with low folate showed higher odds of hypertriglyceridemia (P for trend: 0.049, 0.004, 0.007 and 0.005, respectively).	Folic Acid	104-110	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	75-79
26001398-7	2015	In two independent cohorts, a DNA methylation variant in HIF3A was associated with BMI changes through interactions with total or supplemental vitamin B2, vitamin B12, and folate.	Folic Acid	172-178	hypoxia inducible factor 3 subunit alpha	Homo sapiens	57-62
26309907-2	2015	Recently, studies report that human NAT1 and mouse Nat2 hydrolyze acetyl-coenzyme A (AcCoA) into acetate and coenzyme A in a folate-dependent fashion, a previously unknown function.	Folic Acid	125-131	N-acetyltransferase 2 (arylamine N-acetyltransferase)	Mus musculus	51-55
26309907-3	2015	In this study, our goal was to confirm these findings and determine the apparent Michaelis-Menten kinetic constants (Vmax and Km) of the folate-dependent AcCoA hydrolysis for human NAT1/NAT2, and the rodent analogs rat Nat1/Nat2, mouse Nat1/Nat2, and hamster Nat1/Nat2.	Folic Acid	137-143	N-acetyltransferase 1	Rattus norvegicus	219-223
26309907-3	2015	In this study, our goal was to confirm these findings and determine the apparent Michaelis-Menten kinetic constants (Vmax and Km) of the folate-dependent AcCoA hydrolysis for human NAT1/NAT2, and the rodent analogs rat Nat1/Nat2, mouse Nat1/Nat2, and hamster Nat1/Nat2.	Folic Acid	137-143	N-acetyltransferase 2 (arylamine N-acetyltransferase)	Mus musculus	241-245
26309907-5	2015	Human NAT1 and its rodent analogs rat Nat2, mouse Nat2 and hamster Nat2 catalyzed AcCoA hydrolysis in a folate-dependent manner.	Folic Acid	104-110	N-acetyltransferase 2 (arylamine N-acetyltransferase)	Mus musculus	50-54
25105440-2	2015	The genes MTHFR, MTR, MTRR, and TCN2 play key roles in folate metabolism.	Folic Acid	55-61	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	22-26
26416975-4	2015	In a model of renal fibrosis after folic acid injection, TLR4 mutant mice developed less interstititial fibrosis in comparison to wild-type (WT) mice.	Folic Acid	35-45	toll-like receptor 4	Mus musculus	57-61
26244757-11	2015	RESULTS: NuTu-19 cells express FRalpha which allows intracellular incorporation of folate-targeted compound by endocytosis.	Folic Acid	83-89	rabaptin, RAB GTPase binding effector protein 2	Rattus norvegicus	31-38
26334892-2	2015	Besides, methionine synthase (MTR) gene and methionine synthase reductase (MTRR) gene were folate metabolism involved genes and had been investigated in several previous studies with inconsistent results.	Folic Acid	91-97	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	44-73
26334892-2	2015	Besides, methionine synthase (MTR) gene and methionine synthase reductase (MTRR) gene were folate metabolism involved genes and had been investigated in several previous studies with inconsistent results.	Folic Acid	91-97	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	75-79
26322161-5	2015	High erythrocyte folate status is known to reflect long-term excess folic acid intake, while increased folate oxidation products suggest an increased folate degradation because obesity shows an increased activity of cytochrome P450 2E1, a monooxygenase enzyme that can use folic acid as a substrate.	Folic Acid	68-78	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	216-235
26322161-5	2015	High erythrocyte folate status is known to reflect long-term excess folic acid intake, while increased folate oxidation products suggest an increased folate degradation because obesity shows an increased activity of cytochrome P450 2E1, a monooxygenase enzyme that can use folic acid as a substrate.	Folic Acid	103-109	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	216-235
26322161-5	2015	High erythrocyte folate status is known to reflect long-term excess folic acid intake, while increased folate oxidation products suggest an increased folate degradation because obesity shows an increased activity of cytochrome P450 2E1, a monooxygenase enzyme that can use folic acid as a substrate.	Folic Acid	273-283	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	216-235
25956258-2	2015	In earlier work, we showed that mice with a complete deficiency of methylenetetrahydrofolate reductase (MTHFR), a critical enzyme in folate and homocysteine metabolism, had cognitive impairment with disturbances in choline metabolism.	Folic Acid	86-92	methylenetetrahydrofolate reductase	Mus musculus	104-109
26288227-9	2015	In a similar multiple regression AST was the only independent obesity-related marker associated with serum folate (beta (95% CI) = 0.16 (0.21, 0.51)).	Folic Acid	107-113	solute carrier family 17 member 5	Homo sapiens	33-36
26310574-0	2015	Folic acid promotes the myogenic differentiation of C2C12 murine myoblasts through the Akt signaling pathway.	Folic Acid	0-10	thymoma viral proto-oncogene 1	Mus musculus	87-90
26190800-5	2015	The influx was inhibited by folic acid with IC50 values of 256.1 muM at pH 7.4 and 1.6 muM at pH 5.5, indicating that the mechanisms underlying MTX influx would be different at these pHs.	Folic Acid	28-38	latexin	Homo sapiens	65-68
26190800-5	2015	The influx was inhibited by folic acid with IC50 values of 256.1 muM at pH 7.4 and 1.6 muM at pH 5.5, indicating that the mechanisms underlying MTX influx would be different at these pHs.	Folic Acid	28-38	latexin	Homo sapiens	87-90
26094490-8	2015	In folic acid supplement users compared to nonusers, we established a lower abundance of C-reactive protein (-2.03; P = &lt; 0.01) and higher abundances of apolipoproteins from high-density lipoprotein (HDL), most notably A-I (+1.28; P = &lt; 0.01) and C-I (+1.11; P = 0.016).	Folic Acid	3-13	C-reactive protein	Homo sapiens	89-107
25805039-7	2015	The crude dietary folate and adjusted cobalamin intakes were inversely associated with methylated RARB and BRCA1.	Folic Acid	18-24	retinoic acid receptor beta	Homo sapiens	98-102
26154858-2	2015	The mammalian folic acid cycle is highly complex and the enzymes, methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and methionine synthase reductase (MTRR), have crucial roles in this metabolic pathway.	Folic Acid	14-24	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	142-171
26154858-2	2015	The mammalian folic acid cycle is highly complex and the enzymes, methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and methionine synthase reductase (MTRR), have crucial roles in this metabolic pathway.	Folic Acid	14-24	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	173-177
25805039-8	2015	Low intake of residual folate and cobalamin was correlated with the methylated status of RARB for subjects at &lt;48 years of age, and folate alone was linked to BRCA1 at &gt;48 years of age.	Folic Acid	23-29	retinoic acid receptor beta	Homo sapiens	89-93
25805039-15	2015	Dietary folate and cobalamin intake is inversely associated with methylated RARB and BRCA1.	Folic Acid	8-14	retinoic acid receptor beta	Homo sapiens	76-80
25959374-7	2015	DNA methyltransferase (DNMT) activity increased with intake of folic acid raised DNMT activity in folate-deficient mice.	Folic Acid	63-73	DNA methyltransferase (cytosine-5) 1	Mus musculus	0-21
25959374-7	2015	DNA methyltransferase (DNMT) activity increased with intake of folic acid raised DNMT activity in folate-deficient mice.	Folic Acid	63-73	DNA methyltransferase (cytosine-5) 1	Mus musculus	23-27
25959374-7	2015	DNA methyltransferase (DNMT) activity increased with intake of folic acid raised DNMT activity in folate-deficient mice.	Folic Acid	63-73	DNA methyltransferase (cytosine-5) 1	Mus musculus	81-85
25959374-10	2015	In conclusion, these findings are consistent with a mechanism in which folic acid increases methylation potential and DNMT activity, modifies DNA methylation and ultimately decreases APP, PS1 and Abeta protein levels.	Folic Acid	71-81	DNA methyltransferase (cytosine-5) 1	Mus musculus	118-122
32262577-4	2015	In this study, we report the use of folic acid-bovine serum albumin conjugate (BSA-FA) stabilized AuNSs (BSA-FA-AuNSs) as agents for the targeted photothermal ablation of cervical cancer cells (HeLa).	Folic Acid	36-46	albumin	Homo sapiens	54-67
25801246-3	2015	The single nucleotide polymorphisms, MTHFR C677T, A1298C, MTR A2756G, and MTRR A66G, alter plasmatic folate and homocysteine concentrations, causing problems during the repairment, synthesis, and methylation of the genetic material.	Folic Acid	101-107	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	74-78
25841994-0	2015	Folic acid mediates activation of the pro-oncogene STAT3 via the Folate Receptor alpha.	Folic Acid	0-10	signal transducer and activator of transcription 3	Homo sapiens	51-56
25840270-1	2015	Folic acid (FA) functionalized magnetic bovine serum albumin (BSA) microcapsules (FA-MBMCs) were prepared by a facile sonochemical method, in which FA molecule was immobilized onto the outer walls of microcapsules as a targeting ligand and oleic acid (OA) modifying Fe3O4 magnetic nanoparticles (OA-Fe3O4 MNPs) were wrapped into the microcapsules.	Folic Acid	0-10	albumin	Homo sapiens	47-60
26181632-2	2015	In the present study, we investigated EC0565, a folic acid-derivative of everolimus, as a FR-specific inhibitor of the mammalian target of rapamycin (mTOR).	Folic Acid	48-58	mechanistic target of rapamycin kinase	Homo sapiens	119-148
26181632-2	2015	In the present study, we investigated EC0565, a folic acid-derivative of everolimus, as a FR-specific inhibitor of the mammalian target of rapamycin (mTOR).	Folic Acid	48-58	mechanistic target of rapamycin kinase	Homo sapiens	150-154
25841994-5	2015	We show here that folic acid and folinic acid can activate STAT3 through FRalpha in a Janus Kinase (JAK)-dependent manner, and we demonstrate that gp130 functions as a transducing receptor for this signalling.	Folic Acid	18-28	signal transducer and activator of transcription 3	Homo sapiens	59-64
25841994-7	2015	After folic acid treatment of HeLa cells, up-regulation of the STAT3 responsive genes Cyclin A2 and Vascular Endothelial Growth Factor (VEGF) were verified by qRT-PCR.	Folic Acid	6-16	signal transducer and activator of transcription 3	Homo sapiens	63-68
25841994-7	2015	After folic acid treatment of HeLa cells, up-regulation of the STAT3 responsive genes Cyclin A2 and Vascular Endothelial Growth Factor (VEGF) were verified by qRT-PCR.	Folic Acid	6-16	cyclin A2	Homo sapiens	86-95
25841994-7	2015	After folic acid treatment of HeLa cells, up-regulation of the STAT3 responsive genes Cyclin A2 and Vascular Endothelial Growth Factor (VEGF) were verified by qRT-PCR.	Folic Acid	6-16	vascular endothelial growth factor A	Homo sapiens	100-134
25841994-7	2015	After folic acid treatment of HeLa cells, up-regulation of the STAT3 responsive genes Cyclin A2 and Vascular Endothelial Growth Factor (VEGF) were verified by qRT-PCR.	Folic Acid	6-16	vascular endothelial growth factor A	Homo sapiens	136-140
25841994-10	2015	Our finding that folic acid can activate STAT3 via FRalpha adds complexity to the established roles of B9 vitamins in cancer and neural tube defects.	Folic Acid	17-27	signal transducer and activator of transcription 3	Homo sapiens	41-46
25963948-10	2015	To corroborate mitochondrial functioning further our analysis regarding transcript status of p53 and spargel by qRT-PCR, revealed down regulation of p53 and up regulation of spargel in folate supplemented park (c00062) , which was originally vice a versa.	Folic Acid	185-191	p53	Drosophila melanogaster	93-96
25963948-10	2015	To corroborate mitochondrial functioning further our analysis regarding transcript status of p53 and spargel by qRT-PCR, revealed down regulation of p53 and up regulation of spargel in folate supplemented park (c00062) , which was originally vice a versa.	Folic Acid	185-191	p53	Drosophila melanogaster	149-152
25544674-3	2015	We conducted a case-control study to explore polymorphisms of the major folate pathway genes, including methylenetetrahydrofolate reductase (MTHFR) 677C&gt;T, MTHFR 1298A&gt;C, methionine synthase (MTR) 2756A&gt;G, methionine synthase reductase (MTRR) 66A&gt;G and reduced folate carrier 1 (RFC-1) 80A&gt;G, and their associations with URPL.	Folic Acid	72-78	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	215-244
25544674-3	2015	We conducted a case-control study to explore polymorphisms of the major folate pathway genes, including methylenetetrahydrofolate reductase (MTHFR) 677C&gt;T, MTHFR 1298A&gt;C, methionine synthase (MTR) 2756A&gt;G, methionine synthase reductase (MTRR) 66A&gt;G and reduced folate carrier 1 (RFC-1) 80A&gt;G, and their associations with URPL.	Folic Acid	72-78	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	246-250
25855514-8	2015	The folic acid-enriched diet, fed to T+E2-treated mice, increased voiding frequency in response to intravesicular capsaicin infusion and increased mRNA abundance of the capsaicin-sensitive cation channel transient receptor potential vanilloid subfamily member 1 (Trpv1) in L6 and S1 dorsal root ganglia (DRG) neurons.	Folic Acid	4-14	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	263-268
25809864-10	2015	Maternal prepregnancy folic acid supplementation showed a stronger negative association with CBT risk where the child, mother, or father had the MTRR 66GG genotype (Pinteraction = 0.07, 0.10, and 0.18, respectively).	Folic Acid	22-32	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	145-149
25846410-5	2015	In addition, multiple SNPs in betaine-homocysteine methyltransferase (BHMT and BHMT2) were also identified to be associated with the occurrence of OHDs through significant main infant genetic effects and interaction effects with maternal use of folic acid supplements.	Folic Acid	245-255	betaine--homocysteine S-methyltransferase 2	Homo sapiens	79-84
25809864-12	2015	There was possible protection by the MTRR 66GG genotype, particularly when combined with maternal prepregnancy folic acid supplementation; these results are novel and require replication.	Folic Acid	111-121	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	37-41
25809864-13	2015	IMPACT: The possible interaction between folic acid supplementation and MTRR 66A&gt;G, if confirmed, would strengthen evidence for prepregnancy folate protection against CBT.	Folic Acid	41-51	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	72-76
25809864-13	2015	IMPACT: The possible interaction between folic acid supplementation and MTRR 66A&gt;G, if confirmed, would strengthen evidence for prepregnancy folate protection against CBT.	Folic Acid	144-150	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	72-76
25603223-3	2015	Several non-activating and activating MR1-restricted ligands have been described, which are the degradation products of, or intermediates of, vitamin B9 (folic acid) or vitamin B2 (riboflavin), respectively.	Folic Acid	142-152	major histocompatibility complex, class I-related	Homo sapiens	38-41
25805039-0	2015	Association of folate and other one-carbon related nutrients with hypermethylation status and expression of RARB, BRCA1, and RASSF1A genes in breast cancer patients.	Folic Acid	15-21	retinoic acid receptor beta	Homo sapiens	108-112
25603223-3	2015	Several non-activating and activating MR1-restricted ligands have been described, which are the degradation products of, or intermediates of, vitamin B9 (folic acid) or vitamin B2 (riboflavin), respectively.	Folic Acid	154-164	major histocompatibility complex, class I-related	Homo sapiens	38-41
26030409-6	2015	Taz gene knockdown resulted in upregulation of enzymes of folate and amino acid metabolic pathways in heart mitochondria, demonstrating that Taz-deficiency causes substantive metabolic remodeling in cardiac muscle.	Folic Acid	58-64	tafazzin, phospholipid-lysophospholipid transacylase	Mus musculus	0-3
26221324-2	2015	Methylenetetrahydrofolate dehydrogenase1 (MTHFD1) gene was associated with the susceptibility of OFCs through a complex metabolism correlate with folic acid.	Folic Acid	146-156	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	0-40
26221324-2	2015	Methylenetetrahydrofolate dehydrogenase1 (MTHFD1) gene was associated with the susceptibility of OFCs through a complex metabolism correlate with folic acid.	Folic Acid	146-156	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	42-48
25754229-1	2015	INTRODUCTION: Our objective was to investigate the association between gene polymorphisms of folate cycle (MTHFR 677 C&gt;T, MTHFR 1298 A&gt;C, MTR 2756 A&gt;G, and MTRR 66 A&gt;G) and the risk of pulmonary embolism (PE) in a case-control study.	Folic Acid	93-99	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	165-169
25824034-0	2015	Folic acid supplementation rescues anomalies associated with knockdown of parkin in dopaminergic and serotonergic neurons in Drosophila model of Parkinson"s disease.	Folic Acid	0-10	parkin	Drosophila melanogaster	74-80
25824034-3	2015	Elevated p53 is involved in mitochondrial mediated apoptosis of neuronal cells in Parkinson"s patients who are folate deficient as well.	Folic Acid	111-117	tumor protein p53	Homo sapiens	9-12
25824034-4	2015	The present study therefore attempts to examine the effect of Folic acid (FA) supplementation in alleviation of anomalies associated with parkin knockdown using RNAi approach, specific to Dopaminergic (DA) neurons in Drosophila model system.	Folic Acid	62-72	parkin	Drosophila melanogaster	138-144
25824034-8	2015	Here we show that folic acid supplementation enrich mitochondrial functioning as depicted from improved spargel level and lowered p53 level, which was originally vice versa in parkin knockdown flies cultured in standard media.	Folic Acid	18-28	spargel	Drosophila melanogaster	104-111
25824034-8	2015	Here we show that folic acid supplementation enrich mitochondrial functioning as depicted from improved spargel level and lowered p53 level, which was originally vice versa in parkin knockdown flies cultured in standard media.	Folic Acid	18-28	p53	Drosophila melanogaster	130-133
25824034-8	2015	Here we show that folic acid supplementation enrich mitochondrial functioning as depicted from improved spargel level and lowered p53 level, which was originally vice versa in parkin knockdown flies cultured in standard media.	Folic Acid	18-28	parkin	Drosophila melanogaster	176-182
25824034-9	2015	Our data thus support the potential of folic acid in alleviating the behavioural defects, oxidative stress, augmentation of zinc and ATP levels in parkin knock down flies.	Folic Acid	39-49	parkin	Drosophila melanogaster	147-153
25960653-0	2015	Reversal of multidrug resistance in MCF-7/Adr cells by codelivery of doxorubicin and BCL2 siRNA using a folic acid-conjugated polyethylenimine hydroxypropyl-beta-cyclodextrin nanocarrier.	Folic Acid	104-114	BCL2 apoptosis regulator	Homo sapiens	85-89
25736695-6	2015	In addition to elevated glycine, Gldc disruption also results in abnormal tissue folate profiles, with depletion of one-carbon-carrying folates, as well as growth retardation and reduced cellular proliferation.	Folic Acid	81-87	glycine decarboxylase	Mus musculus	33-37
25686861-4	2015	IR spectrum shows that the ligand act in a bidentate manner and coordinates N4 donor groups of the ligands to Ni(II), Cu(II), Co(II) and Zn(II) ions.	Folic Acid	76-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-132
24195582-8	2015	The IC50 values of docetaxel solution, plain solid fat nanoemulsions, and folate-conjugated PEG-solid fat nanoemulsions were found to be 14.2, 64.9, and 28.8 muM/ml, respectively.	Folic Acid	74-80	latexin	Homo sapiens	158-161
25678124-6	2015	Grafting folic acid (FA) onto the EuGd-MSN surface (EuGd-FA-MSNs) imparts a targeting function to the MSN because of the specificity of the binding of FA to cell surface receptors.	Folic Acid	9-19	moesin	Homo sapiens	39-42
25678124-6	2015	Grafting folic acid (FA) onto the EuGd-MSN surface (EuGd-FA-MSNs) imparts a targeting function to the MSN because of the specificity of the binding of FA to cell surface receptors.	Folic Acid	9-19	moesin	Homo sapiens	60-63
26962174-2	2015	Greater adiposity and insulin resistance have been reported in children of women with high erythrocyte folate but poor vitamin B-12 status during pregnancy.	Folic Acid	103-109	insulin	Homo sapiens	22-29
25736695-7	2015	Formate treatment normalizes the folate profile, restores embryonic growth and prevents NTDs, suggesting that Gldc deficiency causes NTDs through limiting supply of one-carbon units from mitochondrial folate metabolism.	Folic Acid	33-39	glycine decarboxylase	Mus musculus	110-114
25736695-7	2015	Formate treatment normalizes the folate profile, restores embryonic growth and prevents NTDs, suggesting that Gldc deficiency causes NTDs through limiting supply of one-carbon units from mitochondrial folate metabolism.	Folic Acid	201-207	glycine decarboxylase	Mus musculus	110-114
26937386-1	2015	Methylenetetrahydrofolate reductase (MTHFR) is an enzyme key regulator in folate metabolism.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Mus musculus	37-42
25545322-0	2015	Folate-decorated hydrophilic three-arm star-block terpolymer as a novel nanovehicle for targeted co-delivery of doxorubicin and Bcl-2 siRNA in breast cancer therapy.	Folic Acid	0-6	BCL2 apoptosis regulator	Homo sapiens	128-133
25545322-9	2015	The folate-decorated nanomicelleplexes could deliver doxorubicin and Bcl-2 siRNA more efficiently into the same MCF-7 cell and exhibited a higher cytotoxicity than non-targeted nanomicelleplexes.	Folic Acid	4-10	BCL2 apoptosis regulator	Homo sapiens	69-74
25733650-0	2015	High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice.	Folic Acid	5-15	methylenetetrahydrofolate reductase	Mus musculus	44-49
25733650-5	2015	DESIGN: Folic acid-supplemented diet (FASD, 10-fold higher than recommended) and control diet were fed to male Mthfr(+/+) and Mthfr(+/-) mice for 6 mo to assess gene-nutrient interactions.	Folic Acid	8-18	methylenetetrahydrofolate reductase	Mus musculus	111-116
25733650-5	2015	DESIGN: Folic acid-supplemented diet (FASD, 10-fold higher than recommended) and control diet were fed to male Mthfr(+/+) and Mthfr(+/-) mice for 6 mo to assess gene-nutrient interactions.	Folic Acid	8-18	methylenetetrahydrofolate reductase	Mus musculus	126-131
25733650-9	2015	High folic acid inhibited MTHFR activity in vitro, and MTHFR protein was reduced in FASD-fed mice.	Folic Acid	5-15	methylenetetrahydrofolate reductase	Mus musculus	26-31
25733650-14	2015	CONCLUSIONS: We suggest that high folic acid consumption reduces MTHFR protein and activity levels, creating a pseudo-MTHFR deficiency.	Folic Acid	34-44	methylenetetrahydrofolate reductase	Mus musculus	65-70
25733650-14	2015	CONCLUSIONS: We suggest that high folic acid consumption reduces MTHFR protein and activity levels, creating a pseudo-MTHFR deficiency.	Folic Acid	34-44	methylenetetrahydrofolate reductase	Mus musculus	118-123
25733650-16	2015	These preliminary findings may have clinical implications for individuals consuming high-dose folic acid supplements, particularly those who are MTHFR deficient.	Folic Acid	94-104	methylenetetrahydrofolate reductase	Mus musculus	145-150
25477161-0	2015	A NOS3 polymorphism determines endothelial response to folate in children with type 1 diabetes or obesity.	Folic Acid	55-61	nitric oxide synthase 3	Homo sapiens	2-6
25716564-2	2015	Periconceptional intake of folate may reduce the risk of NSCL/P.	Folic Acid	27-33	nescient helix-loop-helix 1	Homo sapiens	57-61
25477161-1	2015	OBJECTIVE: To determine the effect of polymorphisms in NOS3 and folate pathway enzymes on vascular function and folate status and endothelial response to folate in children with diabetes or obesity.	Folic Acid	112-118	nitric oxide synthase 3	Homo sapiens	55-59
25477161-1	2015	OBJECTIVE: To determine the effect of polymorphisms in NOS3 and folate pathway enzymes on vascular function and folate status and endothelial response to folate in children with diabetes or obesity.	Folic Acid	112-118	nitric oxide synthase 3	Homo sapiens	55-59
25477161-3	2015	The effect of NOS3 genotype on endothelial response to folate (5 mg) was assessed in 85 subjects with diabetes and 28 obese subjects who received active treatment during intervention trials.	Folic Acid	55-61	nitric oxide synthase 3	Homo sapiens	14-18
25477161-6	2015	The polymorphism in intron 4 of endothelial nitric oxide synthase altered endothelial response to folate significantly: in subjects with diabetes FMD improved by 6.4 +- 5% (insertion carriers) vs 2.3 +- 6.6% (deletion carriers), P = .01; in obese subjects FMD improved by 1.8 +- 5.4% (insertion carriers) and deteriorated by -3.2 +- 7.2% (deletion carriers), P = .05.	Folic Acid	98-104	nitric oxide synthase 3	Homo sapiens	32-65
25477161-8	2015	CONCLUSIONS: A NOS3 polymorphism predicts endothelial response to folate in children with diabetes or obesity, with implications for vascular risk and folate intervention studies.	Folic Acid	66-72	nitric oxide synthase 3	Homo sapiens	15-19
25477161-8	2015	CONCLUSIONS: A NOS3 polymorphism predicts endothelial response to folate in children with diabetes or obesity, with implications for vascular risk and folate intervention studies.	Folic Acid	151-157	nitric oxide synthase 3	Homo sapiens	15-19
26000261-4	2015	RESULTS: The findings of this study revealed that, overall, the greatest effect of B12 supplementation on decreasing homocysteine levels in patients with ESRDs occurred when it was combined with folate supplementation.	Folic Acid	195-201	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	83-86
25592012-0	2015	Effects of polymorphisms in endothelial nitric oxide synthase and folate metabolizing genes on the concentration of serum nitrate, folate, and plasma total homocysteine after folic acid supplementation: a double-blind crossover study.	Folic Acid	131-137	nitric oxide synthase 3	Homo sapiens	28-61
25592012-0	2015	Effects of polymorphisms in endothelial nitric oxide synthase and folate metabolizing genes on the concentration of serum nitrate, folate, and plasma total homocysteine after folic acid supplementation: a double-blind crossover study.	Folic Acid	175-185	nitric oxide synthase 3	Homo sapiens	28-61
25592012-4	2015	The aim of this study was to investigate whether genetic polymorphisms in endothelial nitric oxide synthase (eNOS) and genes involved in folate metabolism affect the concentration of serum nitrate, serum folate, and plasma total homocysteine in healthy individuals after folic acid supplementation.	Folic Acid	204-210	nitric oxide synthase 3	Homo sapiens	74-107
25592012-4	2015	The aim of this study was to investigate whether genetic polymorphisms in endothelial nitric oxide synthase (eNOS) and genes involved in folate metabolism affect the concentration of serum nitrate, serum folate, and plasma total homocysteine in healthy individuals after folic acid supplementation.	Folic Acid	204-210	nitric oxide synthase 3	Homo sapiens	109-113
25592012-10	2015	The individuals with three polymorphisms in eNOS gene had increased concentration of serum folate and decreased concentration of p-tHcy after folic acid supplementation.	Folic Acid	91-97	nitric oxide synthase 3	Homo sapiens	44-48
25592012-10	2015	The individuals with three polymorphisms in eNOS gene had increased concentration of serum folate and decreased concentration of p-tHcy after folic acid supplementation.	Folic Acid	142-152	nitric oxide synthase 3	Homo sapiens	44-48
25592012-13	2015	CONCLUSIONS: Polymorphisms in eNOS and folate genes affect the concentration of serum folate and p-tHcy but do not have any effect on the concentration of NO3 in healthy individuals after folic acid supplementation.	Folic Acid	188-198	nitric oxide synthase 3	Homo sapiens	30-34
25495051-6	2015	GRMZM2G393334 encodes a putative folylpolyglutamate synthase (FPGS), which functions in one-carbon (C1) metabolism to polyglutamylate substrates of folate-dependent enzymes.	Folic Acid	148-154	folylpolyglutamate synthetase 1	Zea mays	0-13
25548164-4	2015	MTHFD1 functions to condense formate with tetrahydrofolate and serves as the primary entry point of single carbons into folate-dependent one-carbon metabolism in the cytosol.	Folic Acid	52-58	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	0-6
25524527-3	2015	The methylenetetrahydrofolate dehydrogenase (MTHFD1) gene has been proved to play an important role in folate metabolism, which was strongly associated with the high risk for NTD.	Folic Acid	23-29	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	45-51
25524527-4	2015	We focused on three folate metabolism-related single-nucleotide polymorphisms (SNPs) on the MTHFD1 gene to evaluate the associations between MTHFD1 polymorphisms and NTD susceptibility.	Folic Acid	20-26	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	92-98
25548164-5	2015	In this study, we examined the impact of MTHFD1 loss of function on folate-dependent purine, dTMP, and methionine biosynthesis in fibroblasts from the proband with MTHFD1 deficiency.	Folic Acid	68-74	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	41-47
25344837-0	2015	Relationships among folate, alcohol consumption, gene variants in one-carbon metabolism and p16INK4a methylation and expression in healthy breast tissues.	Folic Acid	20-26	cyclin dependent kinase inhibitor 2A	Homo sapiens	92-100
26028103-1	2015	BACKGROUND: The C1561T variant of the glutamate carboxypeptidase II (GCPII) gene is critical for natural methylfolylpolyglutamte (methylfolate) absorption, and has been associated with perturbations in folate metabolism and disease susceptibility.	Folic Acid	136-142	folate hydrolase 1	Homo sapiens	38-67
26028103-1	2015	BACKGROUND: The C1561T variant of the glutamate carboxypeptidase II (GCPII) gene is critical for natural methylfolylpolyglutamte (methylfolate) absorption, and has been associated with perturbations in folate metabolism and disease susceptibility.	Folic Acid	136-142	folate hydrolase 1	Homo sapiens	69-74
26028103-3	2015	Therefore, this study examined whether C1561T-GCPII influences folate metabolism and adenomatous polyp occurrence.	Folic Acid	63-69	folate hydrolase 1	Homo sapiens	46-51
26885500-4	2015	We found that Tanshinone IIA treatment significantly attenuated the folic acid elicited kidney dysfunction on days 3, 14, and 28.	Folic Acid	68-78	ATPase, class II, type 9A	Mus musculus	25-28
26594608-4	2015	An in vitro assay showed that all strains of human-residential bifidobacteria (HRB) were able to produce folate, whereas most strains of non-HRB were not, with the exception of the B. thermophilum and B. longum ssp.	Folic Acid	105-111	ArfGAP with FG repeats 1	Homo sapiens	79-82
26594608-6	2015	The differences in the in vivo production of folate by HRB and non-HRB were confirmed using mono-associated mice.	Folic Acid	45-51	ArfGAP with FG repeats 1	Homo sapiens	67-70
25344837-8	2015	Higher breast folate concentrations were associated with lower p16(INK4a) promoter methylation (P = 0.06).	Folic Acid	14-20	cyclin dependent kinase inhibitor 2A	Homo sapiens	63-66
25344837-8	2015	Higher breast folate concentrations were associated with lower p16(INK4a) promoter methylation (P = 0.06).	Folic Acid	14-20	cyclin dependent kinase inhibitor 2A	Homo sapiens	67-72
25344837-10	2015	Given that this is the first study to indicate that alcohol consumption, breast folate and variation in one-carbon metabolism genes are associated with p16(INK4a) promoter methylation and P16 protein expression in healthy tissues; these findings require replication.	Folic Acid	80-86	cyclin dependent kinase inhibitor 2A	Homo sapiens	152-155
25344837-10	2015	Given that this is the first study to indicate that alcohol consumption, breast folate and variation in one-carbon metabolism genes are associated with p16(INK4a) promoter methylation and P16 protein expression in healthy tissues; these findings require replication.	Folic Acid	80-86	cyclin dependent kinase inhibitor 2A	Homo sapiens	156-161
25344837-10	2015	Given that this is the first study to indicate that alcohol consumption, breast folate and variation in one-carbon metabolism genes are associated with p16(INK4a) promoter methylation and P16 protein expression in healthy tissues; these findings require replication.	Folic Acid	80-86	cyclin dependent kinase inhibitor 2A	Homo sapiens	188-191
25634728-0	2015	Individualized supplementation of folic acid according to polymorphisms of methylenetetrahydrofolate reductase (MTHFR), methionine synthase reductase (MTRR) reduced pregnant complications.	Folic Acid	34-44	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	120-149
25634728-0	2015	Individualized supplementation of folic acid according to polymorphisms of methylenetetrahydrofolate reductase (MTHFR), methionine synthase reductase (MTRR) reduced pregnant complications.	Folic Acid	34-44	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	151-155
26598833-0	2015	Regulation of Folate-Mediated One-Carbon Metabolism by Glycine N-Methyltransferase (GNMT) and Methylenetetrahydrofolate Reductase (MTHFR).	Folic Acid	14-20	glycine N-methyltransferase	Homo sapiens	55-82
26598833-0	2015	Regulation of Folate-Mediated One-Carbon Metabolism by Glycine N-Methyltransferase (GNMT) and Methylenetetrahydrofolate Reductase (MTHFR).	Folic Acid	14-20	glycine N-methyltransferase	Homo sapiens	84-88
26598833-8	2015	Restoring GNMT assists methylfolate-dependent reactions and ameliorates the consequences of folate depletion.	Folic Acid	29-35	glycine N-methyltransferase	Homo sapiens	10-14
26598833-9	2015	GNMT expression in vivo improves folate retention and bioavailability in the liver.	Folic Acid	33-39	glycine N-methyltransferase	Homo sapiens	0-4
25491145-9	2015	Vitamin B9 (folate), D, B6, and B2 intake was inversely associated with risk of colorectal cancer, but further study is needed.	Folic Acid	0-10	gastrin releasing peptide receptor	Homo sapiens	24-34
25084000-8	2015	Interaction between miR-16 and folate was also verified in the AsPC-1 cells.	Folic Acid	31-37	glycerophosphodiester phosphodiesterase 1	Homo sapiens	20-26
25607998-10	2015	Our data indicated associations between plasma folate and vitamin B12 with upper GI cancers in Chinese population.	Folic Acid	47-53	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	66-69
25629224-8	2015	DUSP4 and MAPK8 interacted with calories to alter breast cancer risk; MAPK1 interacted with DOBS, dietary fiber, folate, and BMI; MAP3K2 interacted with dietary fat; and MAPK14 interacted with dietary folate and BMI.	Folic Acid	113-119	mitogen-activated protein kinase 1	Homo sapiens	70-75
25802929-0	2015	Folates Induce Colorectal Carcinoma HT29 Cell Line Proliferation Through Notch1 Signaling.	Folic Acid	0-7	notch receptor 1	Homo sapiens	73-79
25802929-4	2015	Our aim was to demonstrate that high concentrations of FA or its reduced form, 5-methyltetrahydrofolic acid (5-MTHF), increase colorectal carcinoma HT29 cell proliferation through an increase of Notch1 activation and to prove if the inhibition of Notch1 activation by gamma secretase inhibitor, reduce the effect of folic acid.	Folic Acid	97-107	notch receptor 1	Homo sapiens	195-201
25802929-4	2015	Our aim was to demonstrate that high concentrations of FA or its reduced form, 5-methyltetrahydrofolic acid (5-MTHF), increase colorectal carcinoma HT29 cell proliferation through an increase of Notch1 activation and to prove if the inhibition of Notch1 activation by gamma secretase inhibitor, reduce the effect of folic acid.	Folic Acid	97-107	notch receptor 1	Homo sapiens	247-253
26263423-7	2015	An inverse association was observed between CSF folate and CSF levels of IL-6 (P &lt;= 0.05).	Folic Acid	48-54	interleukin 6	Homo sapiens	73-77
26521878-2	2015	For instance, folic acid (FA) as a tumor-targeting ligand is widely used because of overexpression of folate receptor-alpha (FR-alpha) in various kinds of epithelial tumor cells.	Folic Acid	14-24	rabaptin, RAB GTPase binding effector protein 2	Mus musculus	125-133
32262006-3	2014	Bexarotene-loaded bovine serum albumin nanoparticles (BEX-BSANPs) were optimized by a desolvation technique, subsequently conjugated with folate by carbodiimide reaction.	Folic Acid	138-144	albumin	Homo sapiens	25-38
32262006-4	2014	The resultant folate-modified bexarotene-loaded bovine serum albumin nanoparticles (FA-BEX-BSANPs) showed a spherical shape, with a diameter of 195.3 +- 5.6 nm, a zeta potential of -33.64 +- 1.97 mV, and 71.28 +- 1.93 mug folate was coupled per mg BSA.	Folic Acid	14-20	albumin	Homo sapiens	55-68
25505228-1	2015	BACKGROUND: There is limited evidence on the association between dietary folate intake and the risk of breast cancer (BC) by hormone receptor expression in the tumors.	Folic Acid	73-79	nuclear receptor subfamily 4 group A member 1	Homo sapiens	125-141
25505228-15	2015	CONCLUSIONS: Higher dietary folate intake may be associated with a lower risk of sex hormone receptor-negative BC in premenopausal women.	Folic Acid	28-34	nuclear receptor subfamily 4 group A member 1	Homo sapiens	85-101
24422992-6	2014	Clinical response [Physician Global Assessment (PGA) "clear" or "minimal"] was associated with greater CRP reductions vs. no response (PGA "mild" or worse) overall (-0.4 vs. -0.3 mg/L) and in substudies E (-0.4 vs. -0.1 mg/L) and M (-0.5 vs. -0.2 mg/L), but not P (-0.1 vs. -0.4 mg/L).	Folic Acid	48-51	C-reactive protein	Homo sapiens	103-106
25580388-6	2014	Increased folate intake has also been associated with twin birth and insulin resistance in offspring, and altered epigenetic mechanisms of inheritance.	Folic Acid	10-16	insulin	Homo sapiens	69-76
25131448-9	2014	Decreased expression of cathepsin B, a lysosomal protease, was also observed in cells and tissue with folate deficiency.	Folic Acid	102-108	cathepsin Ba	Danio rerio	24-35
32262006-0	2014	Folate-modified bexarotene-loaded bovine serum albumin nanoparticles as a promising tumor-targeting delivery system.	Folic Acid	0-6	albumin	Homo sapiens	41-54
32262006-2	2014	This study exploited a folate-decorated delivery of bexarotene-loaded bovine serum albumin nanoparticles, which could solubilize the poorly water-soluble drug and overcome the nonspecific targeting disadvantage.	Folic Acid	23-29	albumin	Homo sapiens	77-90
25063980-12	2014	In countries that routinely fortify food with folic acid, efforts to identify vitamin B12 deficiency might be more cost-efficiently targeted in areas closest to the Equator.	Folic Acid	46-56	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	86-89
25129243-4	2014	Given the key role of methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) in folate metabolism, it would be of significant interest to assess its role in NSCLP etiology.	Folic Acid	41-47	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	65-71
25196122-1	2014	We report de novo occurrence of the 7p11.2 folate-sensitive fragile site FRA7A in a male with an autistic spectrum disorder (ASD) due to a CGG-repeat expansion mutation (~450 repeats) in a 5" intron of ZNF713.	Folic Acid	43-49	fragile site, folic acid type, rare, fra(7)(p11.2)	Homo sapiens	73-78
25081070-2	2014	We have observed that intestinal tumors are induced in mice fed low-folate diets, and that tumor incidence is increased when these mice also have MTHFR deficiency.	Folic Acid	68-74	methylenetetrahydrofolate reductase	Mus musculus	146-151
24724807-2	2014	Folic acid (FA) improves nitric oxide synthase (NOS) function and reduces progression of diabetic nephropathy in animal models.	Folic Acid	0-10	nitric oxide synthase 2	Homo sapiens	25-46
25213861-0	2014	Nuclear enrichment of folate cofactors and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) protect de novo thymidylate biosynthesis during folate deficiency.	Folic Acid	22-28	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	86-92
25213861-0	2014	Nuclear enrichment of folate cofactors and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) protect de novo thymidylate biosynthesis during folate deficiency.	Folic Acid	62-68	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	86-92
25358257-0	2014	Gefitinib loaded folate decorated bovine serum albumin conjugated carboxymethyl-beta-cyclodextrin nanoparticles enhance drug delivery and attenuate autophagy in folate receptor-positive cancer cells.	Folic Acid	17-23	albumin	Homo sapiens	41-54
25358257-3	2014	In order to utilize FA-FR binding specificity to achieve targeted delivery of drugs into tumor cells, we prepared Gefitinib loaded folate decorated bovine serum albumin conjugated carboxymethyl-beta-cyclodextrin nanoparticles for enhancing drug delivery in cancer cells.	Folic Acid	131-137	albumin	Homo sapiens	155-168
25358257-5	2014	RESULTS: We prepared folic acid (FA)-decorated bovine serum albumin (BSA) conjugated carboxymethyl-beta-cyclodextrin (CM-beta-CD) nanoparticles (FA-BSA-CM-beta-CD NPs) capable of entrapping a hydrophobic Gefitinib.	Folic Acid	21-31	albumin	Homo sapiens	54-67
25299054-5	2014	Vitamin B12 deficiency was defined as vitamin B12&lt;=300 pg/mL without folate deficiency (folate&gt;4 ng/mL).	Folic Acid	72-78	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	8-11
24354357-0	2014	Polymorphism of SLC25A32, the folate transporter gene, is associated with plasma folate levels and bone fractures in Japanese postmenopausal women.	Folic Acid	30-36	solute carrier family 25 member 32	Homo sapiens	16-24
24979295-1	2014	Breast cancer resistance protein (BCRP) in the placenta, encoded by the ABCG2 gene in humans, plays an essential role in regulating fetal exposure to toxicants and the maintenance of cellular folic acid homeostasis.	Folic Acid	192-202	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	72-77
24354357-4	2014	We speculated that the SLC25A32 gene, the mitochondrial inner membrane folate transporter, also could be implicated in the regulation of folate metabolism and fracture.	Folic Acid	71-77	solute carrier family 25 member 32	Homo sapiens	23-31
24354357-11	2014	CONCLUSIONS: These results show that the SLC25A32 gene polymorphism could be a risk factor for lower folate concentration and future fracture.	Folic Acid	101-107	solute carrier family 25 member 32	Homo sapiens	41-49
25066213-4	2014	Thirteen variants in the pyrimidine metabolism genes, DPYD, DPYS, PPAT, and TYMS, also interacted significantly with folate in a multivariant analysis (corrected p = 9.9 x 10-6) but collectively explained only 0.2% of OC risk.	Folic Acid	117-123	dihydropyrimidinase	Homo sapiens	60-64
25039261-5	2014	MTHFD1 is a crucial multifunctional enzyme that catalyzes three separate reactions of the folate pathway and therefore variants in MTHFD1 may also influence migraine susceptibility.	Folic Acid	90-96	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	0-6
25039261-5	2014	MTHFD1 is a crucial multifunctional enzyme that catalyzes three separate reactions of the folate pathway and therefore variants in MTHFD1 may also influence migraine susceptibility.	Folic Acid	90-96	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	131-137
24980623-4	2014	Further modification of the surface of the NH2-MSN with targeting (folate) or fluorescent (RITC) molecules resulted in M-MSN.	Folic Acid	67-73	moesin	Homo sapiens	47-50
24980623-4	2014	Further modification of the surface of the NH2-MSN with targeting (folate) or fluorescent (RITC) molecules resulted in M-MSN.	Folic Acid	67-73	moesin	Homo sapiens	121-124
24980623-10	2014	These folate-conjugated nanoparticles (FA-MSN) exhibited stronger T2-weighted MRI contrast towards HeLa cells as compared to the nanoparticles without folate conjugation, justifying their potential importance in MRI based diagnosis of cancer.	Folic Acid	6-12	moesin	Homo sapiens	42-45
24980623-10	2014	These folate-conjugated nanoparticles (FA-MSN) exhibited stronger T2-weighted MRI contrast towards HeLa cells as compared to the nanoparticles without folate conjugation, justifying their potential importance in MRI based diagnosis of cancer.	Folic Acid	151-157	moesin	Homo sapiens	42-45
25264450-6	2014	RESULTS: Dietary folate intake was positively associated with HDL-C (p = 0.007), HDL-2 (p = 0.0011), HDL-3 (p = 0.0022), and apoA1 (p = 0.001).	Folic Acid	17-23	HDL3	Homo sapiens	101-106
25264450-11	2014	CONCLUSIONS: This study is the first to report that dietary folate intake is associated with HDL-C, HDL-2, HDL-3, and apoA1 levels in humans.	Folic Acid	60-66	apolipoprotein A1	Homo sapiens	118-123
25188308-2	2014	For this strategy, Magnetic Albumin Nanospheres (MAN), composed of superparamagnetic iron oxide nanoparticles (SPIONs) and bovine serum albumin (BSA), were covalently conjugated with folic acid (FA) ligands to enhance the targeting capability of the particles to folate receptor (FR) over-expressing tumours.	Folic Acid	183-193	albumin	Homo sapiens	130-143
24979295-1	2014	Breast cancer resistance protein (BCRP) in the placenta, encoded by the ABCG2 gene in humans, plays an essential role in regulating fetal exposure to toxicants and the maintenance of cellular folic acid homeostasis.	Folic Acid	192-202	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	0-32
24979295-1	2014	Breast cancer resistance protein (BCRP) in the placenta, encoded by the ABCG2 gene in humans, plays an essential role in regulating fetal exposure to toxicants and the maintenance of cellular folic acid homeostasis.	Folic Acid	192-202	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	34-38
25228802-0	2014	Preparation of folic acid-conjugated, doxorubicin-loaded, magnetic bovine serum albumin nanospheres and their antitumor effects in vitro and in vivo.	Folic Acid	15-25	albumin	Homo sapiens	74-87
25228802-1	2014	BACKGROUND: This study aimed to generate targeted folic acid-conjugated, doxorubicin-loaded, magnetic iron oxide bovine serum albumin nanospheres (FA-DOX-BSA MNPs) that lower the side effects and improve the therapeutic effect of antitumor drugs when combined with hyperthermia and targeting therapy.	Folic Acid	50-60	albumin	Homo sapiens	120-133
25228802-12	2014	CONCLUSION: Folic acid-conjugated bovine serum albumin nanospheres composed of mixed doxorubicin and magnetic iron oxide cores can enable controlled and targeted delivery of anticancer drugs and may offer a promising alternative to targeted doxorubicin therapy for nasopharyngeal carcinoma.	Folic Acid	12-22	albumin	Homo sapiens	41-54
24923549-9	2014	The activity of methionine synthase in the liver of TCE and TCE-OH treated rats was inhibited by about 50% indicative of a block in folate synthesis.	Folic Acid	132-138	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	16-35
25264450-6	2014	RESULTS: Dietary folate intake was positively associated with HDL-C (p = 0.007), HDL-2 (p = 0.0011), HDL-3 (p = 0.0022), and apoA1 (p = 0.001).	Folic Acid	17-23	apolipoprotein A1	Homo sapiens	125-130
25264450-11	2014	CONCLUSIONS: This study is the first to report that dietary folate intake is associated with HDL-C, HDL-2, HDL-3, and apoA1 levels in humans.	Folic Acid	60-66	HDL3	Homo sapiens	107-112
24993294-11	2014	Several diet and lifestyle factors, including alcohol consumption, caloric intake, dietary folate, and cigarette smoking, significantly modified the associations with MAPK genes and all-cause mortality.	Folic Acid	91-97	mitogen-activated protein kinase 1	Homo sapiens	167-171
24975935-0	2014	Structural enzymology and inhibition of the bi-functional folate pathway enzyme HPPK-DHPS from the biowarfare agent Francisella tularensis.	Folic Acid	58-64	dihydropteroate synthetase	Escherichia coli	85-89
24975935-1	2014	UNLABELLED: Two valid targets for antibiotic development, 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK) and dihydropteroate synthase (DHPS), catalyze consecutive reactions in folate biosynthesis.	Folic Acid	188-194	dihydropteroate synthetase	Escherichia coli	147-151
25162227-2	2014	For example, deletion of human lymphoid nuclear protein related to AF4/AFF member 3 (LAF4/AFF3) is known to cause severe neurodevelopmental defects, and silencing of the gene is also associated with ID at the folate-sensitive fragile site (FSFS) FRA2A; yet the normal function of this gene in the nervous system is unclear.	Folic Acid	209-215	AF4/FMR2 family member 3	Homo sapiens	85-89
25074866-2	2014	Genetic polymorphisms of reduced folate carrier (RFC1 G80A) and multi-drug resistance-1 (MDR1 C3435T) might affect MTX response and/or toxicity.	Folic Acid	33-39	ATP binding cassette subfamily B member 1	Homo sapiens	58-87
25162227-2	2014	For example, deletion of human lymphoid nuclear protein related to AF4/AFF member 3 (LAF4/AFF3) is known to cause severe neurodevelopmental defects, and silencing of the gene is also associated with ID at the folate-sensitive fragile site (FSFS) FRA2A; yet the normal function of this gene in the nervous system is unclear.	Folic Acid	209-215	AF4/FMR2 family member 3	Homo sapiens	90-94
24965018-0	2014	In silico analysis and experimental validation of azelastine hydrochloride (N4) targeting sodium taurocholate co-transporting polypeptide (NTCP) in HBV therapy.	Folic Acid	76-78	solute carrier family 10 member 1	Homo sapiens	139-143
25202269-1	2014	Common functional polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, a key enzyme in folate and homocysteine metabolism, influence risk for a variety of complex disorders, including developmental, vascular, and neurological diseases.	Folic Acid	58-64	methylenetetrahydrofolate reductase	Mus musculus	76-81
25202269-6	2014	Dietary folate deficiency significantly decreased LCMT1, methylated PP2A and PP2A/Balpha levels in all brain regions examined from aged Mthfr (+/+) mice, and further exacerbated the regional effects of MTHFR deficiency in aged Mthfr (+/-) mice.	Folic Acid	8-14	methylenetetrahydrofolate reductase	Mus musculus	136-141
25202269-6	2014	Dietary folate deficiency significantly decreased LCMT1, methylated PP2A and PP2A/Balpha levels in all brain regions examined from aged Mthfr (+/+) mice, and further exacerbated the regional effects of MTHFR deficiency in aged Mthfr (+/-) mice.	Folic Acid	8-14	methylenetetrahydrofolate reductase	Mus musculus	202-207
25202269-6	2014	Dietary folate deficiency significantly decreased LCMT1, methylated PP2A and PP2A/Balpha levels in all brain regions examined from aged Mthfr (+/+) mice, and further exacerbated the regional effects of MTHFR deficiency in aged Mthfr (+/-) mice.	Folic Acid	8-14	methylenetetrahydrofolate reductase	Mus musculus	227-232
24817375-4	2014	METHODS: We used a folate-nonresponsive Fkbp8 knockout mouse model to elucidate the molecular mechanism(s) of folate nonresponsiveness.	Folic Acid	19-25	FK506 binding protein 8	Mus musculus	40-45
24817375-4	2014	METHODS: We used a folate-nonresponsive Fkbp8 knockout mouse model to elucidate the molecular mechanism(s) of folate nonresponsiveness.	Folic Acid	110-116	FK506 binding protein 8	Mus musculus	40-45
24817375-9	2014	CONCLUSIONS: Folate nonresponsiveness could be attributed in part to increased noggin expression in Fkbp8 (-/-) embryos, resulting in decreased Msx2 expression.	Folic Acid	13-19	FK506 binding protein 8	Mus musculus	100-105
24817375-10	2014	Folate treatment further increases Olig2 and noggin expression, thereby exacerbating ventralization.	Folic Acid	0-6	oligodendrocyte transcription factor 2	Mus musculus	35-40
24805240-9	2014	As folate metabolism has not previously been considered an NADPH producer, confirmation of its functional significance was undertaken through knockdown of methylenetetrahydrofolate dehydrogenase (MTHFD) genes.	Folic Acid	3-9	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	155-194
24874916-6	2014	DNA methylation at the PLAGL1, SGCE, DLK1/MEG3 and IGF2/H19 DMRs was associated with maternal folate levels and also birth weight, suggestive of threshold effects.	Folic Acid	94-100	sarcoglycan epsilon	Homo sapiens	31-35
24874916-6	2014	DNA methylation at the PLAGL1, SGCE, DLK1/MEG3 and IGF2/H19 DMRs was associated with maternal folate levels and also birth weight, suggestive of threshold effects.	Folic Acid	94-100	delta like non-canonical Notch ligand 1	Homo sapiens	37-41
24413630-9	2014	CEPC and VEGF levels were positively correlated with ITAS-CRP and PGA scores.	Folic Acid	66-69	vascular endothelial growth factor A	Homo sapiens	9-13
25140779-0	2014	[Association of folate metabolism genes MTRR and MTHFR with complex congenital abnormalities among Chinese population in Shanxi Province, China].	Folic Acid	16-22	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	40-44
25221392-4	2014	We hypothesize that the polymorphisms in ABCB1, Cyp2C9, Cyp2C19 and methylene tetrahydrofolate reductase (MTHFR) might result in differential expression resulting in differential drug transport, drug metabolism and folate metabolism, which in turn may contribute to the teratogenic impact of AEDs.	Folic Acid	88-94	ATP binding cassette subfamily B member 1	Homo sapiens	41-46
24863754-1	2014	In addition to its well-characterized role in the central nervous system, human glutamate carboxypeptidase II (GCPII; Uniprot ID Q04609) acts as a folate hydrolase in the small intestine, participating in the absorption of dietary polyglutamylated folates (folyl-n-gamma-l-glutamic acid), which are the provitamin form of folic acid (also known as vitamin B9 ).	Folic Acid	248-255	folate hydrolase 1	Homo sapiens	80-109
24863754-1	2014	In addition to its well-characterized role in the central nervous system, human glutamate carboxypeptidase II (GCPII; Uniprot ID Q04609) acts as a folate hydrolase in the small intestine, participating in the absorption of dietary polyglutamylated folates (folyl-n-gamma-l-glutamic acid), which are the provitamin form of folic acid (also known as vitamin B9 ).	Folic Acid	248-255	folate hydrolase 1	Homo sapiens	111-116
24863754-1	2014	In addition to its well-characterized role in the central nervous system, human glutamate carboxypeptidase II (GCPII; Uniprot ID Q04609) acts as a folate hydrolase in the small intestine, participating in the absorption of dietary polyglutamylated folates (folyl-n-gamma-l-glutamic acid), which are the provitamin form of folic acid (also known as vitamin B9 ).	Folic Acid	322-332	folate hydrolase 1	Homo sapiens	80-109
24863754-1	2014	In addition to its well-characterized role in the central nervous system, human glutamate carboxypeptidase II (GCPII; Uniprot ID Q04609) acts as a folate hydrolase in the small intestine, participating in the absorption of dietary polyglutamylated folates (folyl-n-gamma-l-glutamic acid), which are the provitamin form of folic acid (also known as vitamin B9 ).	Folic Acid	322-332	folate hydrolase 1	Homo sapiens	111-116
24863754-1	2014	In addition to its well-characterized role in the central nervous system, human glutamate carboxypeptidase II (GCPII; Uniprot ID Q04609) acts as a folate hydrolase in the small intestine, participating in the absorption of dietary polyglutamylated folates (folyl-n-gamma-l-glutamic acid), which are the provitamin form of folic acid (also known as vitamin B9 ).	Folic Acid	348-358	folate hydrolase 1	Homo sapiens	80-109
24863754-1	2014	In addition to its well-characterized role in the central nervous system, human glutamate carboxypeptidase II (GCPII; Uniprot ID Q04609) acts as a folate hydrolase in the small intestine, participating in the absorption of dietary polyglutamylated folates (folyl-n-gamma-l-glutamic acid), which are the provitamin form of folic acid (also known as vitamin B9 ).	Folic Acid	348-358	folate hydrolase 1	Homo sapiens	111-116
24863754-5	2014	As a result, the crystallographic data reveal considerable details about the binding mode of polyglutamylated folates to GCPII, especially the engagement of the arene binding site in recognizing the folic acid moiety.	Folic Acid	110-117	folate hydrolase 1	Homo sapiens	121-126
24863754-5	2014	As a result, the crystallographic data reveal considerable details about the binding mode of polyglutamylated folates to GCPII, especially the engagement of the arene binding site in recognizing the folic acid moiety.	Folic Acid	199-209	folate hydrolase 1	Homo sapiens	121-126
24302446-4	2014	Treatment with folic acid and tributyrin alone or in combination strongly inhibited the development of glutathione-S-transferase placental form (GSTP)-positive foci.	Folic Acid	15-25	glutathione S-transferase pi 1	Rattus norvegicus	145-149
24961717-7	2014	beta-carotene and folate were associated with reduced glucose metabolism for women, apolipoprotein E epsilon 4 (APOE4) carriers and participants with positive AD family history, but not for their risk-free counterparts.	Folic Acid	18-24	apolipoprotein E	Homo sapiens	84-110
24961717-7	2014	beta-carotene and folate were associated with reduced glucose metabolism for women, apolipoprotein E epsilon 4 (APOE4) carriers and participants with positive AD family history, but not for their risk-free counterparts.	Folic Acid	18-24	apolipoprotein E	Homo sapiens	112-117
24650357-2	2014	Dihydropteroate synthase (DHPS) catalyzes a crucial step in the bacterial pathway of folic acid synthesis, a pathway that is absent in higher vertebrates.	Folic Acid	85-95	deoxyhypusine synthase	Homo sapiens	26-30
24726886-0	2014	Therapeutic efficacy of improved alpha-fetoprotein promoter-mediated tBid delivered by folate-PEI600-cyclodextrin nanopolymer vector in hepatocellular carcinoma.	Folic Acid	87-93	alpha fetoprotein	Homo sapiens	33-50
24915100-0	2014	Preliminary joint X-ray and neutron protein crystallographic studies of ecDHFR complexed with folate and NADP+.	Folic Acid	94-100	dihydrofolate reductase	Escherichia coli	72-78
24915100-1	2014	A crystal of Escherichia coli dihydrofolate reductase (ecDHFR) complexed with folate and NADP+ of 4x1.3x0.7 mm (3.6 mm3) in size was obtained by sequential application of microseeding and macroseeding.	Folic Acid	37-43	dihydrofolate reductase	Escherichia coli	55-61
24915100-4	2014	The neutron and X-ray data were used together for joint refinement of the ecDHFR-folate-NADP+ ternary-complex structure in order to examine the protonation state, protein dynamics and solvent structure of the complex, furthering understanding of the catalytic mechanism.	Folic Acid	81-87	dihydrofolate reductase	Escherichia coli	74-80
24800880-1	2014	PURPOSE: Glycine N-methyltransferase (GNMT) affects genetic stability by regulating the ratio of S-adenosylmethionine to S-adenosylhomocysteine, by binding to folate, and by interacting with environmental carcinogens.	Folic Acid	159-165	glycine N-methyltransferase	Homo sapiens	9-36
24800880-1	2014	PURPOSE: Glycine N-methyltransferase (GNMT) affects genetic stability by regulating the ratio of S-adenosylmethionine to S-adenosylhomocysteine, by binding to folate, and by interacting with environmental carcinogens.	Folic Acid	159-165	glycine N-methyltransferase	Homo sapiens	38-42
25054237-4	2014	The docking study of the folate precursor pABA, its anionic form and natural auxin (indole-3-acetic acid, IAA) with the auxin receptor TIR1 revealed a similar binding mode in the active site.	Folic Acid	25-31	F-box/RNI-like superfamily protein	Arabidopsis thaliana	135-139
25036148-10	2014	In response to the acute renal damage cause by folic acid nephrotoxicity, tubule-specific GREM1 transgenic mice developed increased proteinuria after 7 and 14 days compared with wild-type treated mice.	Folic Acid	47-57	gremlin 1, DAN family BMP antagonist	Mus musculus	90-95
24749811-7	2014	In the case of supplementation to a folic acid deficient diet it lowered the levels of malonidialdehyde and placental IL-6 and TNF-alpha.	Folic Acid	36-46	interleukin 6	Rattus norvegicus	118-122
24749811-7	2014	In the case of supplementation to a folic acid deficient diet it lowered the levels of malonidialdehyde and placental IL-6 and TNF-alpha.	Folic Acid	36-46	tumor necrosis factor	Rattus norvegicus	127-136
26835343-0	2014	Association of folate metabolism genes MTHFR and MTRR with multiple complex congenital malformation risk in Chinese population of Shanxi.	Folic Acid	15-21	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	49-53
26835343-3	2014	In the present study 250 Chinese birth defects cases who suffered 1-8 types of birth defect disease phenotypes were subjected and two genetic variants in two folate metabolism key enzymes, rs1801394 of methionine synthase reductase (MTRR) and rs1801133 of methylenetetrahydrofolate reductase (MTHFR) were genotyped by using SNaPshot method.	Folic Acid	158-164	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	202-231
26835343-3	2014	In the present study 250 Chinese birth defects cases who suffered 1-8 types of birth defect disease phenotypes were subjected and two genetic variants in two folate metabolism key enzymes, rs1801394 of methionine synthase reductase (MTRR) and rs1801133 of methylenetetrahydrofolate reductase (MTHFR) were genotyped by using SNaPshot method.	Folic Acid	158-164	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	233-237
24977710-1	2014	OBJECTIVES: The methylenetetrahydrofolate dehydrogenase (MTHFD1) gene, as one of the key genes involved in the folate pathway, has been reported to play a critical role in the pathogenesis of neural tube defects (NTDs).	Folic Acid	35-41	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	57-63
24650357-2	2014	Dihydropteroate synthase (DHPS) catalyzes a crucial step in the bacterial pathway of folic acid synthesis, a pathway that is absent in higher vertebrates.	Folic Acid	85-95	deoxyhypusine synthase	Homo sapiens	0-24
25404967-10	2014	Significant relationship was also found between homocysteine and vitamin B12 (ss = -0.64, 95% CI = -1.20, -0.08) after controlling for folate and vitamin B6 levels.	Folic Acid	135-141	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	73-76
24448492-2	2014	Along with folic acid, vitamin B12 is also an important determinant of fetal growth and development.	Folic Acid	11-21	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	31-34
24448492-8	2014	The combined association of folate and vitamin B12 expressed as folate to vitamin B12 ratio was correlated to the neonatal anthropometrics.	Folic Acid	28-34	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	82-85
24448492-8	2014	The combined association of folate and vitamin B12 expressed as folate to vitamin B12 ratio was correlated to the neonatal anthropometrics.	Folic Acid	64-70	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	47-50
24704411-0	2014	Divergent effects of folic acid administration on inflammatory status and cholesterol levels in apoE deficient mice.	Folic Acid	21-31	apolipoprotein E	Mus musculus	96-100
24823794-0	2014	From arylamine N-acetyltransferase to folate-dependent acetyl CoA hydrolase: impact of folic acid on the activity of (HUMAN)NAT1 and its homologue (MOUSE)NAT2.	Folic Acid	87-97	N-acetyltransferase 2 (arylamine N-acetyltransferase)	Mus musculus	154-158
24595806-9	2014	Folate deprivation markedly increased growth inhibitory effects of the established MRP1 substrates daunorubicin (~twofold), doxorubicin (~fivefold), and methotrexate (~83-fold) in MRP1-overexpressing cells, proportional to MRP1 expression.	Folic Acid	0-6	ATP binding cassette subfamily B member 1	Homo sapiens	83-87
24595806-9	2014	Folate deprivation markedly increased growth inhibitory effects of the established MRP1 substrates daunorubicin (~twofold), doxorubicin (~fivefold), and methotrexate (~83-fold) in MRP1-overexpressing cells, proportional to MRP1 expression.	Folic Acid	0-6	ATP binding cassette subfamily B member 1	Homo sapiens	180-184
24595806-9	2014	Folate deprivation markedly increased growth inhibitory effects of the established MRP1 substrates daunorubicin (~twofold), doxorubicin (~fivefold), and methotrexate (~83-fold) in MRP1-overexpressing cells, proportional to MRP1 expression.	Folic Acid	0-6	ATP binding cassette subfamily B member 1	Homo sapiens	180-184
24595806-10	2014	In conclusion, this study demonstrates that increased cellular folate concentrations induce MRP1/ABCC1-related drug efflux and drug resistance.	Folic Acid	63-69	ATP binding cassette subfamily B member 1	Homo sapiens	92-96
24595806-10	2014	In conclusion, this study demonstrates that increased cellular folate concentrations induce MRP1/ABCC1-related drug efflux and drug resistance.	Folic Acid	63-69	ATP binding cassette subfamily C member 1	Homo sapiens	97-102
24805240-9	2014	As folate metabolism has not previously been considered an NADPH producer, confirmation of its functional significance was undertaken through knockdown of methylenetetrahydrofolate dehydrogenase (MTHFD) genes.	Folic Acid	3-9	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	196-201
24714357-0	2014	A Phase I/Ib study of folate immune (EC90 vaccine administered with GPI-0100 adjuvant followed by EC17) with interferon-alpha and interleukin-2 in patients with renal cell carcinoma.	Folic Acid	22-28	interleukin 2	Homo sapiens	130-143
24714357-2	2014	In this open-label, phase I/II clinical study, we report the safety, pharmacokinetics, and antitumor activity of folate immune with concurrent interleukin-2 (IL-2) and interferon-alpha (IFN-alpha) in patients with recurrent or metastatic RCC.	Folic Acid	113-119	interleukin 2	Homo sapiens	158-162
24714357-2	2014	In this open-label, phase I/II clinical study, we report the safety, pharmacokinetics, and antitumor activity of folate immune with concurrent interleukin-2 (IL-2) and interferon-alpha (IFN-alpha) in patients with recurrent or metastatic RCC.	Folic Acid	113-119	interferon alpha 1	Homo sapiens	186-195
24627342-7	2014	Here, we probe METE gene regulation by B12 and methionine/folate cycle metabolites in both marine and freshwater microalgal species.	Folic Acid	58-64	uncharacterized protein	Chlamydomonas reinhardtii	15-19
24256214-3	2014	MATERIALS AND METHODS: In the present work, transferrin (Tf) and folate (Fa) were linked onto polyethylene glycol-phosphatidylethanolamine (PEG-PE) separately to get transferrin-PEG-PE (T-PEG-PE) and folate-PEG-PE (F-PEG-PE) ligands for the surface modification of carriers.	Folic Acid	65-71	transferrin	Homo sapiens	166-177
24256214-3	2014	MATERIALS AND METHODS: In the present work, transferrin (Tf) and folate (Fa) were linked onto polyethylene glycol-phosphatidylethanolamine (PEG-PE) separately to get transferrin-PEG-PE (T-PEG-PE) and folate-PEG-PE (F-PEG-PE) ligands for the surface modification of carriers.	Folic Acid	200-206	transferrin	Homo sapiens	44-55
24256214-3	2014	MATERIALS AND METHODS: In the present work, transferrin (Tf) and folate (Fa) were linked onto polyethylene glycol-phosphatidylethanolamine (PEG-PE) separately to get transferrin-PEG-PE (T-PEG-PE) and folate-PEG-PE (F-PEG-PE) ligands for the surface modification of carriers.	Folic Acid	200-206	transferrin	Homo sapiens	57-59
24629913-0	2014	Folic acid stimulation of neural stem cell proliferation is associated with altered methylation profile of PI3K/Akt/CREB.	Folic Acid	0-10	AKT serine/threonine kinase 1	Rattus norvegicus	112-115
24736781-0	2014	Maternal high folic acid supplement promotes glucose intolerance and insulin resistance in male mouse offspring fed a high-fat diet.	Folic Acid	14-24	insulin	Homo sapiens	69-76
24710923-6	2014	It was found that transient folate deprivation combined with SMs was sufficient to permit reprogramming from mouse embryonic fibroblasts (MEFs) in the presence of transcription factors, Oct4 and Klf4, within 25 days, replacing Sox2 and c-Myc, and accelerated the generation of mouse iPSCs.	Folic Acid	28-34	Kruppel-like factor 4 (gut)	Mus musculus	195-199
24868906-4	2014	On the other hand, high bioavailability is a consequence of folic appearing in milk mainly in form of mono glutamates and also of a presence of a protein ready to bind folates (FBP--folic binding protein).	Folic Acid	168-175	ECB2	Homo sapiens	177-180
24864083-8	2014	Moreover, research demonstrated a correlation between deficiency of omega-3, vitamin D, B12, antioxidant vitamins and folic acid in diet, and the development and exacerbation of symptoms of multiple sclerosis.	Folic Acid	118-128	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	88-91
24615977-4	2014	The sensitivity of the herein proposed method, named R-ELISA, was attempted in the detection of folate receptor expression on human ovarian cancer cells by functionalizing PLA2 with folic acid.	Folic Acid	182-192	phospholipase A2 group IB	Homo sapiens	172-176
24668664-1	2014	We examined whether polymorphisms in the methylenetetrahydrofolate dehydrogenase (MTHFD) and transcobalamin (TC) genes, which are involved in folate metabolism, affect maternal risk for Down syndrome.	Folic Acid	60-66	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	82-87
24649091-2	2014	Two important folate-metabolizing enzymes involved in the folate/homocysteine metabolic pathway are 5,10-methylenetetrahydrofolate reductase (MTHFR) and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1).	Folic Acid	14-20	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	153-194
23996837-7	2014	Our findings suggest that natural food folate intake is inversely associated with breast cancer risk and that this association may vary by race, menopausal status or ER status.	Folic Acid	39-45	estrogen receptor 1	Homo sapiens	166-168
24595806-0	2014	Folates provoke cellular efflux and drug resistance of substrates of the multidrug resistance protein 1 (MRP1).	Folic Acid	0-7	ATP binding cassette subfamily B member 1	Homo sapiens	73-103
24595806-0	2014	Folates provoke cellular efflux and drug resistance of substrates of the multidrug resistance protein 1 (MRP1).	Folic Acid	0-7	ATP binding cassette subfamily B member 1	Homo sapiens	105-109
24595806-1	2014	Cellular folate concentration was earlier reported to be a critical factor in the activity and expression of the multidrug resistance protein MRP1 (ABCC1).	Folic Acid	9-15	ATP binding cassette subfamily B member 1	Homo sapiens	142-146
24595806-1	2014	Cellular folate concentration was earlier reported to be a critical factor in the activity and expression of the multidrug resistance protein MRP1 (ABCC1).	Folic Acid	9-15	ATP binding cassette subfamily C member 1	Homo sapiens	148-153
24595806-2	2014	Since MRP1 mediates resistance to a variety of therapeutic drugs, we investigated whether the cellular folate concentration influences the MRP1-mediated cellular resistance against drugs.	Folic Acid	103-109	ATP binding cassette subfamily B member 1	Homo sapiens	139-143
24595806-5	2014	In folate-deprived 2008/MRP1 cells, the MRP1-mediated efflux of its model substrate calcein decreased to ~55 % of the initial efflux rate under folate-rich conditions.	Folic Acid	3-9	ATP binding cassette subfamily B member 1	Homo sapiens	24-28
24595806-5	2014	In folate-deprived 2008/MRP1 cells, the MRP1-mediated efflux of its model substrate calcein decreased to ~55 % of the initial efflux rate under folate-rich conditions.	Folic Acid	3-9	ATP binding cassette subfamily B member 1	Homo sapiens	40-44
24595806-5	2014	In folate-deprived 2008/MRP1 cells, the MRP1-mediated efflux of its model substrate calcein decreased to ~55 % of the initial efflux rate under folate-rich conditions.	Folic Acid	144-150	ATP binding cassette subfamily B member 1	Homo sapiens	24-28
24595806-5	2014	In folate-deprived 2008/MRP1 cells, the MRP1-mediated efflux of its model substrate calcein decreased to ~55 % of the initial efflux rate under folate-rich conditions.	Folic Acid	144-150	ATP binding cassette subfamily B member 1	Homo sapiens	40-44
24595806-7	2014	Folate depletion for 5-10 days markedly increased (~500 %) cellular steady-state accumulation of calcein in 2008/MRP1 cells and moderately in 2008wt cells.	Folic Acid	0-6	ATP binding cassette subfamily B member 1	Homo sapiens	113-117
24649091-2	2014	Two important folate-metabolizing enzymes involved in the folate/homocysteine metabolic pathway are 5,10-methylenetetrahydrofolate reductase (MTHFR) and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1).	Folic Acid	14-20	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	196-202
24649091-2	2014	Two important folate-metabolizing enzymes involved in the folate/homocysteine metabolic pathway are 5,10-methylenetetrahydrofolate reductase (MTHFR) and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1).	Folic Acid	58-64	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	153-194
24649091-2	2014	Two important folate-metabolizing enzymes involved in the folate/homocysteine metabolic pathway are 5,10-methylenetetrahydrofolate reductase (MTHFR) and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1).	Folic Acid	58-64	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	196-202
24535845-9	2014	CONCLUSION: These results support previous studies suggesting that maternal and fetal SNPs within folate, homocysteine, and transsulfuration pathways are associated with CTD risk.	Folic Acid	98-104	CTD	Homo sapiens	170-173
24535715-1	2014	Observational studies have consistently shown associations between mild deficiencies in folate and vitamin B12 with increased risk of a myriad of common diseases.	Folic Acid	88-94	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	107-110
24368157-1	2014	MTHFD1 1958G&gt;A, a polymorphism in folate metabolism, increases risk of pregnancy complications.	Folic Acid	37-43	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	0-6
24559276-3	2014	The serine hydroxymethyhransferase (SHMT), methionine synthase (MS), methionine synthase reductase (MTRR) and cystathionine beta synthase (CBS) regulate key reactions in the folate and Hcy metabolism.	Folic Acid	174-180	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	69-98
24559276-3	2014	The serine hydroxymethyhransferase (SHMT), methionine synthase (MS), methionine synthase reductase (MTRR) and cystathionine beta synthase (CBS) regulate key reactions in the folate and Hcy metabolism.	Folic Acid	174-180	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	100-104
24559276-3	2014	The serine hydroxymethyhransferase (SHMT), methionine synthase (MS), methionine synthase reductase (MTRR) and cystathionine beta synthase (CBS) regulate key reactions in the folate and Hcy metabolism.	Folic Acid	174-180	cystathionine beta-synthase	Homo sapiens	110-137
24559276-3	2014	The serine hydroxymethyhransferase (SHMT), methionine synthase (MS), methionine synthase reductase (MTRR) and cystathionine beta synthase (CBS) regulate key reactions in the folate and Hcy metabolism.	Folic Acid	174-180	cystathionine beta-synthase	Homo sapiens	139-142
24558445-0	2014	Recoupling of eNOS with folic acid prevents abdominal aortic aneurysm formation in angiotensin II-infused apolipoprotein E null mice.	Folic Acid	24-34	apolipoprotein E	Mus musculus	106-122
23922098-3	2014	We postulated that GNMT plays a role in folate-dependent methyl group homeostasis and helps maintain genome integrity by promoting nucleotide biosynthesis and DNA repair.	Folic Acid	40-46	glycine N-methyltransferase	Homo sapiens	19-23
23922098-4	2014	To test the hypothesis, GNMT was over-expressed in GNMT-null cell lines cultured in conditions of folate abundance or restriction.	Folic Acid	98-104	glycine N-methyltransferase	Homo sapiens	24-28
24343843-0	2014	Associations between cigarette smoking, hormone therapy, and folate intake with incident colorectal cancer by TP53 protein expression level in a population-based cohort of older women.	Folic Acid	61-67	tumor protein p53	Homo sapiens	110-114
24283460-0	2014	Improved stability and antidiabetic potential of insulin containing folic acid functionalized polymer stabilized multilayered liposomes following oral administration.	Folic Acid	68-78	insulin	Homo sapiens	49-56
24556396-3	2014	The semi-invariant MAIT T-cell antigen receptor (TCR) recognises riboflavin and folic acid metabolites bound by MR1 in a conserved docking mode, and thus acts like a pattern recognition receptor.	Folic Acid	80-90	major histocompatibility complex, class I-related	Homo sapiens	112-115
23996892-4	2014	By adjustment for oxidative risk factors of HCC, the compound CT and TT genotypes in relative to the CC wild-type were associated with 83% reduced lymphocytic p53 oxidative lesions of HCC patients with RBC folate lower than 688 ng/mL (OR: 0.17, 95%CI: 0.07-0.43).	Folic Acid	206-212	tumor protein p53	Homo sapiens	159-162
23996892-10	2014	CONCLUSION: Our data demonstrated that reduced MTHFR activities associated with the MTHFR T allele may interact with RBC folate as the risk modifiers of lymphocytic p53 oxidative lesions of HCC patients.	Folic Acid	121-127	tumor protein p53	Homo sapiens	165-168
27025730-5	2014	An additional anti-folate target is dihyropteroate synthase (DHPS), which is unique to prokaryotes as they cannot acquire folate through dietary means.	Folic Acid	19-25	deoxyhypusine synthase	Homo sapiens	61-65
27025730-5	2014	An additional anti-folate target is dihyropteroate synthase (DHPS), which is unique to prokaryotes as they cannot acquire folate through dietary means.	Folic Acid	122-128	deoxyhypusine synthase	Homo sapiens	61-65
27025730-10	2014	These inhibitors are also likely to interact with the enzymatic neighbors in the folate pathway that bind products of the DHFR or DHPS enzymes and/or substrates of similar substructure.	Folic Acid	81-87	deoxyhypusine synthase	Homo sapiens	130-134
24283460-1	2014	The present study reports the folic acid (FA) functionalized insulin loaded stable liposomes with improved bioavailability following oral administration.	Folic Acid	30-40	insulin	Homo sapiens	61-68
24177262-4	2014	The aim of this study was to investigate the effects of high-dose folic acid supplementation during pregnancy on LPS-induced NTDs.	Folic Acid	66-76	toll-like receptor 4	Mus musculus	113-116
24177262-7	2014	Interestingly, supplementation with folic acid (3mg/kg/d) during pregnancy significantly alleviated LPS-induced NTDs.	Folic Acid	36-46	toll-like receptor 4	Mus musculus	100-103
24177262-8	2014	Additionally, folic acid significantly attenuated LPS-induced fetal growth restriction and skeletal malformations.	Folic Acid	14-24	toll-like receptor 4	Mus musculus	50-53
24294939-0	2014	Modulation of intestinal folate absorption by erythropoietin in vitro.	Folic Acid	25-31	erythropoietin	Homo sapiens	46-60
24177262-9	2014	Additional experiment showed that folic acid attenuated LPS-induced glutathione (GSH) depletion in maternal liver and placentas.	Folic Acid	34-44	toll-like receptor 4	Mus musculus	56-59
24177262-10	2014	Moreover, folic acid significantly attenuated LPS-induced expression of placental MyD88.	Folic Acid	10-20	toll-like receptor 4	Mus musculus	46-49
24177262-11	2014	Additionally, folic acid inhibited LPS-induced c-Jun NH2-terminal kinase (JNK) phosphorylation and nuclear factor kappa B (NF-kappaB) activation in placentas.	Folic Acid	14-24	toll-like receptor 4	Mus musculus	35-38
24177262-11	2014	Additionally, folic acid inhibited LPS-induced c-Jun NH2-terminal kinase (JNK) phosphorylation and nuclear factor kappa B (NF-kappaB) activation in placentas.	Folic Acid	14-24	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	99-121
24177262-11	2014	Additionally, folic acid inhibited LPS-induced c-Jun NH2-terminal kinase (JNK) phosphorylation and nuclear factor kappa B (NF-kappaB) activation in placentas.	Folic Acid	14-24	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	123-132
24177262-12	2014	Correspondingly, folic acid significantly attenuated LPS-induced tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 in placentas, maternal serum and amniotic fluid.	Folic Acid	17-27	toll-like receptor 4	Mus musculus	53-56
24177262-12	2014	Correspondingly, folic acid significantly attenuated LPS-induced tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 in placentas, maternal serum and amniotic fluid.	Folic Acid	17-27	tumor necrosis factor	Mus musculus	65-98
24177262-12	2014	Correspondingly, folic acid significantly attenuated LPS-induced tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 in placentas, maternal serum and amniotic fluid.	Folic Acid	17-27	interleukin 1 beta	Mus musculus	100-122
24177262-12	2014	Correspondingly, folic acid significantly attenuated LPS-induced tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 in placentas, maternal serum and amniotic fluid.	Folic Acid	17-27	interleukin 6	Mus musculus	127-131
24177262-13	2014	In conclusion, supplementation with high-dose folic acid during pregnancy protects against LPS-induced NTDs through its anti-inflammatory and anti-oxidative effects.	Folic Acid	46-56	toll-like receptor 4	Mus musculus	91-94
24294939-8	2014	The absorptive flux (apical to basolateral) of folic acid was enhanced by EPO treatment in a dose-dependent manner, which was companied with the significant up-regulation of reduced folate carrier (RFC) and apical proton coupled folate transporter (PCFT).	Folic Acid	182-188	erythropoietin	Homo sapiens	74-77
24294939-9	2014	The efflux (basolaterial to apical) of folic acid was enhanced only by the high dose of EPO treatment, which was associated with the significant up-regulation of apical multidrug resistance-associated protein 2 (MRP2).	Folic Acid	39-49	erythropoietin	Homo sapiens	88-91
24294939-12	2014	As a conclusion, intestinal folate absorption was enhanced by EPO treatment in vitro.	Folic Acid	28-34	erythropoietin	Homo sapiens	62-65
24294939-13	2014	Our findings provided direct evidence to establish the correlation between EPO and folate homeostasis.	Folic Acid	83-89	erythropoietin	Homo sapiens	75-78
25003120-7	2014	Results suggest that maternal micronutrient imbalance (excess folic acid with vitamin B12 deficiency) leads to lower mRNA levels of methylene tetrahydrofolate reductase (MTHFR) and methionine synthase , but higher cystathionine b-synthase (CBS) and Phosphatidylethanolamine-N-methyltransferase (PEMT) as compared to control.	Folic Acid	62-72	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	181-200
24162586-0	2014	Association between maternal folate concentrations during pregnancy and insulin resistance in Indian children.	Folic Acid	29-35	insulin	Homo sapiens	72-79
24162586-2	2014	Lower maternal vitamin B12 and higher folate concentrations were associated with higher offspring insulin resistance.	Folic Acid	38-44	insulin	Homo sapiens	98-105
25059801-9	2014	This phenotype was partly related to a deranged 1-carbon metabolism due to an imbalance in vitamin B12 (low) and folate (high) nutrition, which was also related to insulin resistance in the offspring.	Folic Acid	113-119	insulin	Homo sapiens	164-171
23623598-9	2014	Meanwhile, plasma CEA, NSE and SCC were negatively correlated with serum folate.	Folic Acid	73-79	CEA cell adhesion molecule 3	Homo sapiens	18-21
23623598-9	2014	Meanwhile, plasma CEA, NSE and SCC were negatively correlated with serum folate.	Folic Acid	73-79	enolase 2	Homo sapiens	23-26
24246419-0	2014	Among vitamin B12 deficient older people, high folate levels are associated with worse cognitive function: combined data from three cohorts.	Folic Acid	47-53	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	14-17
24246419-1	2014	BACKGROUND: Folate fortification of food aims to reduce the number of babies born with neural tube defects, but has been associated with cognitive impairment when vitamin B12 levels are deficient.	Folic Acid	12-18	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	171-174
24294939-4	2014	The objective of this study was to investigate the effect of EPO on intestinal transport of folate in vitro and to elucidate the possible mechanism(s) involved in this regulation.	Folic Acid	92-98	erythropoietin	Homo sapiens	61-64
24294939-5	2014	Transport assays of folic acid were performed in Caco-2 monolayers treated with EPO.	Folic Acid	20-30	erythropoietin	Homo sapiens	80-83
24294939-6	2014	The effect of EPO on the expression of transporters involved in the folate absorption was investigated.	Folic Acid	68-74	erythropoietin	Homo sapiens	14-17
24294939-8	2014	The absorptive flux (apical to basolateral) of folic acid was enhanced by EPO treatment in a dose-dependent manner, which was companied with the significant up-regulation of reduced folate carrier (RFC) and apical proton coupled folate transporter (PCFT).	Folic Acid	47-57	erythropoietin	Homo sapiens	74-77
23794259-3	2014	The aim of this study was to evaluate the expression levels of circulating miR-22, miR-24, and miR-34a, possibly involved in folate pathway, in NSCLC patients treated with pemetrexed compared with healthy controls and to investigate their impact on patient clinical outcomes.	Folic Acid	125-131	microRNA 22	Homo sapiens	75-81
24724504-3	2014	In addition, drug Gliotoxin (GTX) and targeting molecules (Lysozyme, p53 and Folic acid) have been incorporated into f-SWNT-COS. f-SWNTs-COS-GTX-p53, f-SWNTs-COS-GTX-lysozyme, f-SWNTs-COS-GTX-FA have been physiochemically characterized for DDS.	Folic Acid	77-87	tumor protein p53	Homo sapiens	145-148
23894123-4	2013	Folic acid (FA) and epidermal growth factor (EGF) were further attached to the BPEI-coated YVO4:Bi(3+),Eu(3+) NCs and exhibited effective positioning of fluorescent NCs toward the targeted folate receptor overexpressed in HeLa cells or EGFR overexpressed in A431 cells with low cytotoxicity.	Folic Acid	0-10	epidermal growth factor receptor	Homo sapiens	236-240
24564401-9	2014	A hypothetical increase in PAL from 1.4 to 1.9 was associated with a DRI that was 8%-13% higher for folate and vitamin C (men) and 5%-15% higher for calcium and iron (women).	Folic Acid	100-106	leucine rich repeat, Ig-like and transmembrane domains 1	Homo sapiens	27-30
24239764-5	2014	IR spectra show that the ligands act in a bidentate manner and coordinates N4 donor groups of the ligands to Ni(II), Cu(II) and Co(II) ions.	Folic Acid	75-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-134
24246419-10	2014	CONCLUSIONS: High folate or folic acid supplements may be detrimental to cognition in older people with low vitamin B12 levels.	Folic Acid	18-24	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	116-119
24246419-10	2014	CONCLUSIONS: High folate or folic acid supplements may be detrimental to cognition in older people with low vitamin B12 levels.	Folic Acid	28-38	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	116-119
24876842-5	2014	Among the 91 PCOS patients treated with NAC + Inositol + folic, insulin resistance was present in 44 subjects (A) and absent in 47 (B).	Folic Acid	57-62	insulin	Homo sapiens	64-71
23459165-2	2013	The single nucleotide polymorphisms, MTHFR C677T, A1298C, MTR A2756G and MTRR A66G, cause alteration in the homocysteine levels and reduced enzymatic activity that generates deficiency in the assimilation of folates associated with DNA damage; that is, why it is important to know if the single nucleotide polymorphisms are associated with the pathological characteristics and development of prostate cancer, through a case-control retrospective study.	Folic Acid	208-215	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	73-77
24108785-1	2013	BACKGROUND: Folic acid supplementation in those with a low vitamin B-12 intake or status may have adverse effects.	Folic Acid	12-22	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	67-71
24532985-7	2013	It is believed that the increase in the concentration of Hcy in PD can affect genetic polymorphisms of the folate metabolic pathway genes, such as MTHFR (C677T, A1298C and G1793A), MTR (A2756G), and MTHFD1 (G1958A), whose frequencies tend to increase in PD patients, as well as the reduced concentration of B vitamins.	Folic Acid	107-113	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	199-205
23820268-9	2013	Taken together, these data demonstrated that treatment with folic acid may reverse cardiac contractile and intracellular Ca(2+) anomalies through ablation of CaMKII phosphorylation and RYR Ca(2+) leak.	Folic Acid	60-70	ryanodine receptor 1, skeletal muscle	Mus musculus	185-188
24090688-0	2013	Association between dietary folate intake and serum insulin-like growth factor-1 levels in healthy old women.	Folic Acid	28-34	insulin like growth factor 1	Homo sapiens	52-80
24090688-6	2013	RESULTS: The mean IGF-1 level for the sample as a whole was 136.2 +- 38.9 mug/l, and was significantly lower in women with a higher folate intake (p = 0.04).	Folic Acid	132-138	insulin like growth factor 1	Homo sapiens	18-23
24090688-7	2013	On simple linear analysis, the vitamins found associated with serum IGF-1 levels were: folates (r: -0.25; p = 0.003); vitamin E (r: -0.21; p = 0.01); vitamin D (r: -0.17; p = 0.03); and riboflavin (r: -0.16; p=0.03).	Folic Acid	87-94	insulin like growth factor 1	Homo sapiens	68-73
24090688-8	2013	After removing the effect of calorie, protein, carbohydrate and fat intake, and other known potential confounders (age, BMI, alcohol intake), only folate intake correlated with IGF-1 levels (r = -0.17; p = 0.04).	Folic Acid	147-153	insulin like growth factor 1	Homo sapiens	177-182
24090688-9	2013	CONCLUSION: A folate-rich diet could have the effect of lowering circulating IGF-1 levels in elderly women.	Folic Acid	14-20	insulin like growth factor 1	Homo sapiens	77-82
23790844-3	2013	In this study, the response of the synthetic form of folates known as folic acid to UV irradiation in the presence of beta-lactoglobulin (beta-LG), bovine serum albumin (BSA) and alpha-lactalbumin (alpha-LA) was investigated using circular dichroism, absorbance and fluorescence spectroscopy.	Folic Acid	53-60	albumin	Homo sapiens	155-168
23790844-3	2013	In this study, the response of the synthetic form of folates known as folic acid to UV irradiation in the presence of beta-lactoglobulin (beta-LG), bovine serum albumin (BSA) and alpha-lactalbumin (alpha-LA) was investigated using circular dichroism, absorbance and fluorescence spectroscopy.	Folic Acid	53-60	lactalbumin alpha	Homo sapiens	179-196
23790844-3	2013	In this study, the response of the synthetic form of folates known as folic acid to UV irradiation in the presence of beta-lactoglobulin (beta-LG), bovine serum albumin (BSA) and alpha-lactalbumin (alpha-LA) was investigated using circular dichroism, absorbance and fluorescence spectroscopy.	Folic Acid	53-60	lactalbumin alpha	Homo sapiens	198-206
23790844-3	2013	In this study, the response of the synthetic form of folates known as folic acid to UV irradiation in the presence of beta-lactoglobulin (beta-LG), bovine serum albumin (BSA) and alpha-lactalbumin (alpha-LA) was investigated using circular dichroism, absorbance and fluorescence spectroscopy.	Folic Acid	70-80	albumin	Homo sapiens	155-168
23790844-3	2013	In this study, the response of the synthetic form of folates known as folic acid to UV irradiation in the presence of beta-lactoglobulin (beta-LG), bovine serum albumin (BSA) and alpha-lactalbumin (alpha-LA) was investigated using circular dichroism, absorbance and fluorescence spectroscopy.	Folic Acid	70-80	lactalbumin alpha	Homo sapiens	179-196
23790844-3	2013	In this study, the response of the synthetic form of folates known as folic acid to UV irradiation in the presence of beta-lactoglobulin (beta-LG), bovine serum albumin (BSA) and alpha-lactalbumin (alpha-LA) was investigated using circular dichroism, absorbance and fluorescence spectroscopy.	Folic Acid	70-80	lactalbumin alpha	Homo sapiens	198-206
23790844-4	2013	Photodecomposition of folic acid was delayed in the presence of the proteins, which ranked in the order beta-LG&gt;BSA&gt;alpha-LA in terms of effectiveness.	Folic Acid	22-32	lactalbumin alpha	Homo sapiens	122-130
23918616-0	2013	PCMT1 gene polymorphisms, maternal folate metabolism, and neural tube defects: a case-control study in a population with relatively low folate intake.	Folic Acid	136-142	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Homo sapiens	0-5
24007195-6	2013	For example, the abundance of TNF-alpha was 100% greater in folate- and biotin-supplemented U937 cells compared with biotin-deficient and folate-supplemented cells.	Folic Acid	60-66	tumor necrosis factor	Homo sapiens	30-39
23959833-3	2013	It is still controversial and ambiguous between the functional polymorphisms of folate metabolism genes 5,10-methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTRR), and methionine synthase reductase (MTR) and risk of adult meningioma.	Folic Acid	80-86	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	175-179
23959833-3	2013	It is still controversial and ambiguous between the functional polymorphisms of folate metabolism genes 5,10-methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTRR), and methionine synthase reductase (MTR) and risk of adult meningioma.	Folic Acid	80-86	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	186-215
23959833-3	2013	It is still controversial and ambiguous between the functional polymorphisms of folate metabolism genes 5,10-methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTRR), and methionine synthase reductase (MTR) and risk of adult meningioma.	Folic Acid	80-86	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	175-178
24007195-6	2013	For example, the abundance of TNF-alpha was 100% greater in folate- and biotin-supplemented U937 cells compared with biotin-deficient and folate-supplemented cells.	Folic Acid	138-144	tumor necrosis factor	Homo sapiens	30-39
24205029-3	2013	Mice null for the murine NAT1 homolog (Nat2) show several phenotypes consistent with altered folate homeostasis.	Folic Acid	93-99	N-acetyltransferase 2 (arylamine N-acetyltransferase)	Mus musculus	39-43
24205029-4	2013	However, the exact role of Nat2 in the folate pathway in vivo has not been reported.	Folic Acid	39-45	N-acetyltransferase 2 (arylamine N-acetyltransferase)	Mus musculus	27-31
23777916-4	2013	The folate moiety binds quickly to PSMA-positive tumors, and the PSA-responsive moiety is cleaved by PSA that was enriched in tumor tissues.	Folic Acid	4-10	folate hydrolase 1	Homo sapiens	35-39
23711784-2	2013	Carboxyl functionalized MSN (MSN/COOH) was firstly prepared and then modified with folate as the cancer targeting moiety and a near infrared fluorescent dye as labeling segment.	Folic Acid	83-89	moesin	Homo sapiens	24-27
23711784-2	2013	Carboxyl functionalized MSN (MSN/COOH) was firstly prepared and then modified with folate as the cancer targeting moiety and a near infrared fluorescent dye as labeling segment.	Folic Acid	83-89	moesin	Homo sapiens	29-32
23711784-3	2013	Folate was conjugated to MSN/COOH via functional polyethyleneglycol (PEG), constructing the vector MSN/COOH-PEG-FA.	Folic Acid	0-6	moesin	Homo sapiens	25-28
23711784-3	2013	Folate was conjugated to MSN/COOH via functional polyethyleneglycol (PEG), constructing the vector MSN/COOH-PEG-FA.	Folic Acid	0-6	moesin	Homo sapiens	99-102
23904512-2	2013	Folates are generally taken up into cells by specific transporters, mainly the reduced folate carrier RFC1 (SLC19A1 protein) and the high-affinity folate receptors FOLR1 and FOLR2.	Folic Acid	0-7	replication factor C (activator 1) 1	Mus musculus	102-106
23904512-2	2013	Folates are generally taken up into cells by specific transporters, mainly the reduced folate carrier RFC1 (SLC19A1 protein) and the high-affinity folate receptors FOLR1 and FOLR2.	Folic Acid	87-93	replication factor C (activator 1) 1	Mus musculus	102-106
23892004-10	2013	Action spectrum for 1muM folic acid photodegradation was determined.	Folic Acid	25-35	latexin	Homo sapiens	21-24
23273571-5	2013	Folate deficiency decreased the circadian amplitude of vasopressin and the clock protein PERIOD 2 (PER2) in the master clock, slowed the rate of re-entrainment of behavioral rhythms after delayed light-dark cycle and reduced light-induced phase-delays, without detectable morphologic changes in the retina, such as the number of melanopsinergic ganglion cells, that might have impaired photodetection.	Folic Acid	0-6	circadian locomotor output cycles kaput	Mus musculus	75-80
24160198-8	2013	RESULTS: In receiver operating curves characteristics for detection on vitamin B12 deficiency using single measurements, serum folate has the greatest area under the curve (0.87) and homocysteine the lowest (0.67).	Folic Acid	127-133	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	79-82
24522413-1	2013	BACKGROUND: Supraphysiological levels (SFL) of serum folate (SF) derived from flour fortification with folic acid (FA) could be risky among older adults with low vitamin B12 (B12) levels.	Folic Acid	53-59	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	175-178
23796957-0	2013	Folic acid modulates eNOS activity via effects on posttranslational modifications and protein-protein interactions.	Folic Acid	0-10	nitric oxide synthase 3	Homo sapiens	21-25
23796957-3	2013	Particular focus was placed on folic acid-induced changes in posttranslational modifications of endothelial nitric oxide synthase (eNOS).	Folic Acid	31-41	nitric oxide synthase 3	Homo sapiens	96-129
23796957-3	2013	Particular focus was placed on folic acid-induced changes in posttranslational modifications of endothelial nitric oxide synthase (eNOS).	Folic Acid	31-41	nitric oxide synthase 3	Homo sapiens	131-135
23796957-9	2013	Folic acid promoted eNOS dephosphorylation at negative regulatory sites, and increased phosphorylation at positive regulatory sites.	Folic Acid	0-10	nitric oxide synthase 3	Homo sapiens	20-24
23796957-11	2013	Inhibition of PI3K/Akt revealed specific roles for this kinase pathway in folic acid-mediated eNOS phosphorylation.	Folic Acid	74-84	AKT serine/threonine kinase 1	Homo sapiens	19-22
23796957-11	2013	Inhibition of PI3K/Akt revealed specific roles for this kinase pathway in folic acid-mediated eNOS phosphorylation.	Folic Acid	74-84	nitric oxide synthase 3	Homo sapiens	94-98
23796957-13	2013	Folic acid-mediated eNOS activation involves the modulation of eNOS phosphorylation status at multiple residues and positive changes in important protein-protein interactions.	Folic Acid	0-10	nitric oxide synthase 3	Homo sapiens	20-24
23796957-13	2013	Folic acid-mediated eNOS activation involves the modulation of eNOS phosphorylation status at multiple residues and positive changes in important protein-protein interactions.	Folic Acid	0-10	nitric oxide synthase 3	Homo sapiens	63-67
22459404-1	2013	BACKGROUND: The deficiency in methyl donors, folate and vitamin B12, increases homocysteine and produces myocardium hypertrophy with impaired mitochondrial fatty acid oxidation and increased BNP, through hypomethylation of peroxisome-proliferator-activated-receptor gamma co-activator-1alpha, in rat.	Folic Acid	45-51	natriuretic peptide B	Rattus norvegicus	191-194
22459404-1	2013	BACKGROUND: The deficiency in methyl donors, folate and vitamin B12, increases homocysteine and produces myocardium hypertrophy with impaired mitochondrial fatty acid oxidation and increased BNP, through hypomethylation of peroxisome-proliferator-activated-receptor gamma co-activator-1alpha, in rat.	Folic Acid	45-51	PPARG coactivator 1 alpha	Rattus norvegicus	223-291
23624207-5	2013	This is the first report to show that curcumin (10-50 muM) causes a significant, dose-dependent, 2-3 fold increase in uptake of radiolabelled folic acid and methotrexate into KG-1 cells both at 24 h and 48 h of treatment.	Folic Acid	142-152	latexin	Homo sapiens	54-57
23424995-8	2013	KEY RESULTS: Folate up-regulated p21/p27 through a Src/ERK-dependent mechanism that accounted for its anti-proliferative effects on RASMC.	Folic Acid	13-19	Eph receptor B1	Rattus norvegicus	55-58
23424995-9	2013	Folate protected RASMC from the effects of homocysteine by reducing AKT1, focal adhesion kinase (FAK), paxillin, and p190RhoGAP activation/phosphorylation, along with cytosolic levels of p21 and p27, and increasing RhoA activation.	Folic Acid	0-6	AKT serine/threonine kinase 1	Rattus norvegicus	68-72
23424995-9	2013	Folate protected RASMC from the effects of homocysteine by reducing AKT1, focal adhesion kinase (FAK), paxillin, and p190RhoGAP activation/phosphorylation, along with cytosolic levels of p21 and p27, and increasing RhoA activation.	Folic Acid	0-6	Rho GTPase activating protein 35	Rattus norvegicus	117-127
23893181-9	2013	For ER negative patients, only three pathways including the folate biosynthesis pathway were enriched with DEGs and none of them overlapped with those of ER positive patients.	Folic Acid	60-66	estrogen receptor 1	Homo sapiens	4-6
23964315-0	2013	Effects of parental folate deficiency on the folate content, global DNA methylation, and expressions of FRalpha, IGF-2 and IGF-1R in the postnatal rat liver.	Folic Acid	20-26	rabaptin, RAB GTPase binding effector protein 2	Rattus norvegicus	104-111
23964315-8	2013	Positive correlations were found between the hepatic folate content and global DNA methylation and protein expressions of FRalpha, IGF-2 and IGF-1R, whereas an inverse correlation was found between hepatic folate content and plasma homocysteine level in the 3-week-old rat pup.	Folic Acid	53-59	rabaptin, RAB GTPase binding effector protein 2	Rattus norvegicus	122-129
23725631-5	2013	These results support the impact of MTHFR C677T polymorphism and importance of folic acid intake in the etiology of nsCL/P.	Folic Acid	79-89	nescient helix-loop-helix 1	Homo sapiens	116-120
23905113-5	2013	RESULTS: Iron, copper , folate, vitamin B12 deficiencies and folate with vitamin B12 deficiency were detected in 13%, 32% , 13% , 32% and 11% women of the childbearing ages, respectively .	Folic Acid	61-67	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	81-84
24522413-1	2013	BACKGROUND: Supraphysiological levels (SFL) of serum folate (SF) derived from flour fortification with folic acid (FA) could be risky among older adults with low vitamin B12 (B12) levels.	Folic Acid	53-59	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	170-173
23592803-6	2013	Furthermore, there are concerns relating to potential adverse effects for older adults with low vitamin B12 status of over-exposure to folic acid in countries where there is mandatory fortification of food with folic acid.	Folic Acid	135-145	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	104-107
23592803-7	2013	The aim of this review is to examine the known and emerging issues related to vitamin B12 in ageing, its assessment and inter-relationship with folate.	Folic Acid	144-150	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	86-89
23273571-5	2013	Folate deficiency decreased the circadian amplitude of vasopressin and the clock protein PERIOD 2 (PER2) in the master clock, slowed the rate of re-entrainment of behavioral rhythms after delayed light-dark cycle and reduced light-induced phase-delays, without detectable morphologic changes in the retina, such as the number of melanopsinergic ganglion cells, that might have impaired photodetection.	Folic Acid	0-6	period circadian clock 2	Mus musculus	89-97
23273571-5	2013	Folate deficiency decreased the circadian amplitude of vasopressin and the clock protein PERIOD 2 (PER2) in the master clock, slowed the rate of re-entrainment of behavioral rhythms after delayed light-dark cycle and reduced light-induced phase-delays, without detectable morphologic changes in the retina, such as the number of melanopsinergic ganglion cells, that might have impaired photodetection.	Folic Acid	0-6	period circadian clock 2	Mus musculus	99-103
23273571-5	2013	Folate deficiency decreased the circadian amplitude of vasopressin and the clock protein PERIOD 2 (PER2) in the master clock, slowed the rate of re-entrainment of behavioral rhythms after delayed light-dark cycle and reduced light-induced phase-delays, without detectable morphologic changes in the retina, such as the number of melanopsinergic ganglion cells, that might have impaired photodetection.	Folic Acid	0-6	circadian locomotor output cycles kaput	Mus musculus	119-124
23273571-6	2013	In conclusion, folate deficiency and consecutive hyperhomocysteinemia led to dampened PER2 and vasopressin oscillations in the master clock and reduced responsiveness to photic resetting, which constitute hallmarks of aging effects on circadian rhythmicity.	Folic Acid	15-21	period circadian clock 2	Mus musculus	86-90
23273571-6	2013	In conclusion, folate deficiency and consecutive hyperhomocysteinemia led to dampened PER2 and vasopressin oscillations in the master clock and reduced responsiveness to photic resetting, which constitute hallmarks of aging effects on circadian rhythmicity.	Folic Acid	15-21	circadian locomotor output cycles kaput	Mus musculus	134-139
23697869-7	2013	Instead, folate had an independent positive association with Apo A1 levels in univariate and multiple regression models.	Folic Acid	9-15	apolipoprotein A1	Homo sapiens	61-67
23754956-7	2013	Interestingly, 13 of the 18 identified variants were coding and 11 of the 13 target genes have known functions related to B(12) and folate pathways.	Folic Acid	132-138	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	122-127
23697869-10	2013	CONCLUSIONS: Analyzing over 1500 subjects we found an independent positive association between plasma folate (major dietary determinant of tHcy) and Apo A1 levels among those who later did not develop a first myocardial infarction.	Folic Acid	102-108	apolipoprotein A1	Homo sapiens	149-155
23519469-1	2013	We have investigated the role of ceramide in the cellular adaptation to folate stress induced by Aldh1l1, the enzyme involved in the regulation of folate metabolism.	Folic Acid	72-78	aldehyde dehydrogenase 1 family member L1	Homo sapiens	97-104
23697869-0	2013	Plasma folate, but not homocysteine, is associated with Apolipoprotein A1 levels in a non-fortified population.	Folic Acid	7-13	apolipoprotein A1	Homo sapiens	56-73
23519469-1	2013	We have investigated the role of ceramide in the cellular adaptation to folate stress induced by Aldh1l1, the enzyme involved in the regulation of folate metabolism.	Folic Acid	147-153	aldehyde dehydrogenase 1 family member L1	Homo sapiens	97-104
22961839-5	2013	However, statistically significant interactions modifying CC risk were observed for DNMT1 I311V with dietary folate, methionine, vitamin B2 , and vitamin B12 intake and for MTRR I22M with dietary folate, a predefined one-carbon dietary pattern, and vitamin B6 intake.	Folic Acid	196-202	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	173-177
23439585-3	2013	Cellular acquisition of folate is mediated by folate receptors (FRs), whose expression is also modulated by folate status, through an Hcy-dependent regulation mechanism involving heterogeneous nuclear ribonucleoprotein-E1 (hnRNP-E1).	Folic Acid	24-30	poly(rC) binding protein 1	Homo sapiens	179-221
23439585-3	2013	Cellular acquisition of folate is mediated by folate receptors (FRs), whose expression is also modulated by folate status, through an Hcy-dependent regulation mechanism involving heterogeneous nuclear ribonucleoprotein-E1 (hnRNP-E1).	Folic Acid	24-30	poly(rC) binding protein 1	Homo sapiens	223-231
23439585-3	2013	Cellular acquisition of folate is mediated by folate receptors (FRs), whose expression is also modulated by folate status, through an Hcy-dependent regulation mechanism involving heterogeneous nuclear ribonucleoprotein-E1 (hnRNP-E1).	Folic Acid	46-52	poly(rC) binding protein 1	Homo sapiens	179-221
23439585-3	2013	Cellular acquisition of folate is mediated by folate receptors (FRs), whose expression is also modulated by folate status, through an Hcy-dependent regulation mechanism involving heterogeneous nuclear ribonucleoprotein-E1 (hnRNP-E1).	Folic Acid	46-52	poly(rC) binding protein 1	Homo sapiens	223-231
23414105-1	2013	In this study, soy protein isolate (SPI) was conjugated with folic acid (FA) to prepare nanoparticles for target-specific drug delivery.	Folic Acid	61-71	chromogranin A	Homo sapiens	36-39
22918695-1	2013	Folate hydrolase 1 (FOLH1) gene encodes intestinal folate hydrolase, which regulates intestinal absorption of dietary folate.	Folic Acid	51-57	folate hydrolase 1	Homo sapiens	0-18
22918695-1	2013	Folate hydrolase 1 (FOLH1) gene encodes intestinal folate hydrolase, which regulates intestinal absorption of dietary folate.	Folic Acid	51-57	folate hydrolase 1	Homo sapiens	20-25
23374533-9	2013	Melatonin, folic acid or their combination also restored the baseline levels of IFN-gamma and Akt1 mRNA expression.	Folic Acid	11-21	AKT serine/threonine kinase 1	Rattus norvegicus	94-98
23374533-10	2013	The combination of melatonin and folic acid exhibited ability to reduce the markers of liver injury induced by CCl4 and restore the oxidative stability, the level of inflammatory cytokines, the lipid profile and the cell survival Akt1 signals.	Folic Acid	33-43	C-C motif chemokine ligand 4	Rattus norvegicus	111-115
23374533-10	2013	The combination of melatonin and folic acid exhibited ability to reduce the markers of liver injury induced by CCl4 and restore the oxidative stability, the level of inflammatory cytokines, the lipid profile and the cell survival Akt1 signals.	Folic Acid	33-43	AKT serine/threonine kinase 1	Rattus norvegicus	230-234
23751476-0	2013	[Effect of folate in modulating the expression of DNA methyltransferase 1 and methyl-CpG-binding protein 2 in cervical cancer cell lines].	Folic Acid	11-17	methyl-CpG binding protein 2	Homo sapiens	78-106
23751476-1	2013	OBJECTIVE: To explore the effects of folate on the expression of DNA methyltransferase 1 (DNMT1) and methyl-CpG-binding protein 2 (MeCP2) in cervical cancer cell lines.	Folic Acid	37-43	methyl-CpG binding protein 2	Homo sapiens	101-129
23751476-1	2013	OBJECTIVE: To explore the effects of folate on the expression of DNA methyltransferase 1 (DNMT1) and methyl-CpG-binding protein 2 (MeCP2) in cervical cancer cell lines.	Folic Acid	37-43	methyl-CpG binding protein 2	Homo sapiens	131-136
23751476-9	2013	CONCLUSION: Our finding indicated that adequate folate could effectively inhibit the proliferation of cervical cancer cells and facilitate their apoptosis in vitro, thus would reverse the aberration protein expression of DNMT1 and MeCP2.	Folic Acid	48-54	methyl-CpG binding protein 2	Homo sapiens	231-236
23586109-11	2004	PSMA may play an important role in the progression of prostate cancer and glutamatergic neurotransmission, as well as in the absorption of folate (9).	Folic Acid	139-145	folate hydrolase 1	Homo sapiens	0-4
23420882-3	2013	In this study, we demonstrate a novel role for the canonical complement 5a receptor (C5aR) in the development of the mammalian neural tube under conditions of maternal dietary folic acid deficiency.	Folic Acid	176-186	complement C5a receptor 1	Homo sapiens	85-89
23420882-6	2013	Ablation of the C5ar1 gene or the administration of a specific C5aR peptide antagonist to folic acid-deficient pregnant mice resulted in a high prevalence of severe anterior neural tube defect-associated congenital malformations.	Folic Acid	90-100	complement component 5a receptor 1	Mus musculus	63-67
23112124-11	2013	CONCLUSION: Low dietary folate or Mthfr deficiency during pregnancy may result in adverse pregnancy outcomes by altering expression of the inflammatory mediators ApoAI and IFN-gamma in spleen and placenta.	Folic Acid	24-30	interferon gamma	Mus musculus	172-181
23338599-0	2013	Folic acid uptake by the human syncytiotrophoblast is affected by gestational diabetes, hyperleptinemia, and TNF-alpha.	Folic Acid	0-10	tumor necrosis factor	Homo sapiens	109-118
23497688-6	2013	RESULTS: Adequate levels of selenium and folate post-weaning affected gene expression in colon and liver of offspring, including decreasing Slc2a4 gene expression.	Folic Acid	41-47	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	140-146
23266799-2	2013	To test this hypothesis, breast and prostate cancer cases and controls were subjected to whole gene screening of GCPII and correlated with plasma folate levels and PSMA expression.	Folic Acid	146-152	folate hydrolase 1	Homo sapiens	113-118
23178654-0	2013	Folic acid inhibits endothelial cell migration through inhibiting the RhoA activity mediated by activating the folic acid receptor/cSrc/p190RhoGAP-signaling pathway.	Folic Acid	0-10	ras homolog family member A	Homo sapiens	70-74
23178654-0	2013	Folic acid inhibits endothelial cell migration through inhibiting the RhoA activity mediated by activating the folic acid receptor/cSrc/p190RhoGAP-signaling pathway.	Folic Acid	0-10	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	131-135
23178654-1	2013	Previously, our in vivo studies demonstrated that folic acid (FA) could inhibit angiogenesis and in vitro studies showed that FA reduced vascular endothelial cell proliferation through activating the cSrc/ERK-2/NFkappaB/p53 pathway mediated by FA receptor (FR).	Folic Acid	50-60	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	200-204
23178654-1	2013	Previously, our in vivo studies demonstrated that folic acid (FA) could inhibit angiogenesis and in vitro studies showed that FA reduced vascular endothelial cell proliferation through activating the cSrc/ERK-2/NFkappaB/p53 pathway mediated by FA receptor (FR).	Folic Acid	50-60	mitogen-activated protein kinase 1	Homo sapiens	205-210
23178654-1	2013	Previously, our in vivo studies demonstrated that folic acid (FA) could inhibit angiogenesis and in vitro studies showed that FA reduced vascular endothelial cell proliferation through activating the cSrc/ERK-2/NFkappaB/p53 pathway mediated by FA receptor (FR).	Folic Acid	50-60	nuclear factor kappa B subunit 1	Homo sapiens	211-219
23178654-1	2013	Previously, our in vivo studies demonstrated that folic acid (FA) could inhibit angiogenesis and in vitro studies showed that FA reduced vascular endothelial cell proliferation through activating the cSrc/ERK-2/NFkappaB/p53 pathway mediated by FA receptor (FR).	Folic Acid	50-60	tumor protein p53	Homo sapiens	220-223
23001810-0	2013	Differential gene expression and methylation in the retinoid/PPARA pathway and of tumor suppressors may modify intestinal tumorigenesis induced by low folate in mice.	Folic Acid	151-157	peroxisome proliferator activated receptor alpha	Mus musculus	61-66
23001810-8	2013	Low folate increased Ppara and Aldh1a1 expression, and decreased Bcmo1, Sprr2a, and Bmp5 expression in BALB/c, compared to BALB/c on control diets.	Folic Acid	4-10	peroxisome proliferator activated receptor alpha	Mus musculus	21-26
23001810-10	2013	CONCLUSION: Disturbed regulation of the retinoid/PPARA pathway, which influences oxidative damage, and altered expression of tumor suppressors may contribute to intestinal tumorigenesis induced by low-folate intake.	Folic Acid	201-207	peroxisome proliferator activated receptor alpha	Mus musculus	49-54
23112124-0	2013	Low dietary folate and methylenetetrahydrofolate reductase deficiency may lead to pregnancy complications through modulation of ApoAI and IFN-gamma in spleen and placenta, and through reduction of methylation potential.	Folic Acid	12-18	interferon gamma	Mus musculus	138-147
23391913-3	2013	This result suggests that the amelioration of hyperhomocysteinemia in response to folate supplementation had enhanced the removal of homocysteine via methionine synthase.	Folic Acid	82-88	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	150-169
23887111-7	2013	Although the specific consequences of perturbation in maternal and fetal methyl transfer remain to be determined, a profound influence is suggested by the demonstrated relationship between maternal folate and B12 insufficiency and metabolic programming.	Folic Acid	198-204	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	209-212
23094987-3	2013	Methionine synthase reductase (5-methyltetrahydrofolate-homocysteine methyltransferase reductase MTRR) plays an important role in folic acid pathway and a common polymorphism (c.66A&gt;G) has been associated with DS but results were controversial.	Folic Acid	130-140	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	0-29
23094987-3	2013	Methionine synthase reductase (5-methyltetrahydrofolate-homocysteine methyltransferase reductase MTRR) plays an important role in folic acid pathway and a common polymorphism (c.66A&gt;G) has been associated with DS but results were controversial.	Folic Acid	130-140	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	97-101
23766646-0	2013	Low-weight polyethylenimine cross-linked 2-hydroxypopyl-beta-cyclodextrin and folic acid as an efficient and nontoxic siRNA carrier for gene silencing and tumor inhibition by VEGF siRNA.	Folic Acid	78-88	vascular endothelial growth factor A	Homo sapiens	175-179
23846752-2	2013	Here we describe the structures of a human MAIT TCR in complex with human MR1 presenting a non-stimulatory ligand derived from folic acid and an agonist ligand derived from a riboflavin metabolite.	Folic Acid	127-137	major histocompatibility complex, class I-related	Homo sapiens	74-77
23887113-8	2013	Follow-up studies revealed that higher maternal folate in pregnancy predicted higher adiposity and insulin resistance in the child at 6 years of age, and that low maternal vitamin B12 exaggerated the risk of insulin resistance.	Folic Acid	48-54	insulin	Homo sapiens	99-106
23256225-3	2004	Two site-specific carboxypeptidase activities have been assigned to PSMA: N-acetylated alpha-linked acidic dipeptidase, which hydrolyzes the neuropeptide N-acetyl-aspartyl-glutamate (NAAG) in the brain to regulate release of neurotransmitters, and folate hydrolase activity, which is characterized by the cleavage of terminal glutamates from poly- and gamma-glutamated folates, which play a role in the cellular uptake of dietary folate (2).	Folic Acid	248-254	folate hydrolase 1	Homo sapiens	68-72
23859041-8	2013	Interaction within the p38-signaling pathway included MAPK14 with calories, carbohydrates saturated fat, selenium, vitamin C; MAP3K2 and carbohydrates, and folic acid.	Folic Acid	156-166	mitogen-activated protein kinase 1	Homo sapiens	23-26
23256224-3	2004	Two site-specific carboxypeptidase activities have been assigned to PSMA: N-acetylated alpha-linked acidic dipeptidase, which hydrolyzes the neuropeptide N-acetyl-aspartyl-glutamate (NAAG) in the brain to regulate release of neurotransmitters, and folate hydrolase activity, which is characterized by the cleavage of terminal glutamates from poly- and gamma-glutamated folates, which play a role in the cellular uptake of dietary folate (2).	Folic Acid	248-254	folate hydrolase 1	Homo sapiens	68-72
23123153-2	2012	Methylenetetrahydrofolate reductase (Mthfr) plays a key role in folate metabolism by channeling one-carbon units between nucleotide synthesis and methylation reactions.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Mus musculus	37-42
23046900-7	2012	Higher maternal folate status during pregnancy was associated positively with insulin resistance in 6-year-olds.	Folic Acid	16-22	insulin	Homo sapiens	78-85
22843228-0	2012	Folic acid inhibits endothelial cell proliferation through activating the cSrc/ERK 2/NF-kappaB/p53 pathway mediated by folic acid receptor.	Folic Acid	0-10	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	74-78
22843228-0	2012	Folic acid inhibits endothelial cell proliferation through activating the cSrc/ERK 2/NF-kappaB/p53 pathway mediated by folic acid receptor.	Folic Acid	0-10	mitogen-activated protein kinase 1	Homo sapiens	79-84
22843228-0	2012	Folic acid inhibits endothelial cell proliferation through activating the cSrc/ERK 2/NF-kappaB/p53 pathway mediated by folic acid receptor.	Folic Acid	0-10	nuclear factor kappa B subunit 1	Homo sapiens	85-94
22843228-0	2012	Folic acid inhibits endothelial cell proliferation through activating the cSrc/ERK 2/NF-kappaB/p53 pathway mediated by folic acid receptor.	Folic Acid	0-10	tumor protein p53	Homo sapiens	95-98
23051753-6	2012	The structure of MR1 in complex with 6-formyl pterin, a folic acid (vitamin B9) metabolite, shows the pterin ring sequestered within MR1.	Folic Acid	56-66	major histocompatibility complex, class I-related	Homo sapiens	17-20
23051753-6	2012	The structure of MR1 in complex with 6-formyl pterin, a folic acid (vitamin B9) metabolite, shows the pterin ring sequestered within MR1.	Folic Acid	56-66	major histocompatibility complex, class I-related	Homo sapiens	133-136
23051753-6	2012	The structure of MR1 in complex with 6-formyl pterin, a folic acid (vitamin B9) metabolite, shows the pterin ring sequestered within MR1.	Folic Acid	68-78	major histocompatibility complex, class I-related	Homo sapiens	17-20
23051753-6	2012	The structure of MR1 in complex with 6-formyl pterin, a folic acid (vitamin B9) metabolite, shows the pterin ring sequestered within MR1.	Folic Acid	68-78	major histocompatibility complex, class I-related	Homo sapiens	133-136
22828209-8	2012	Furthermore, bioinformatics analyses and in vitro studies suggested that miR-302a plays a critical role in mediating the effects of folate on cell proliferation and cell cycle-specific apoptosis by targeting Lats2 gene.	Folic Acid	132-138	microRNA 302a	Mus musculus	73-81
23014492-5	2012	This study aimed to determine whether folate supplementation of Bhmt(-/-) mice reverses, and folate deficiency exacerbates, these metabolic changes.	Folic Acid	38-44	betaine-homocysteine methyltransferase	Mus musculus	64-68
22765944-1	2012	Novel eight Co(II), Ni(II), Cu(II), Cu(I) and Pd(II) complexes with [N(4)] ligand (L) i.e. 2-amino-N-{2-[(2-aminobenzoyl)amino]ethyl}benzamide have been synthesized and structurally characterized by elemental analysis, spectral, thermal (TG/DTG), magnetic, and molar conductivity measurements.	Folic Acid	69-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-18
23387078-1	2012	Methionine synthase (MS, EC2.1.1.13), a key enzyme in the folate metabolism area catalyzing methyl transfer from N5-methyltetrahydrofolate to homocysteine to give tetrahydrofolate and methionine, takes a core position in folate cycle, one-carbon-unit transfer and sculpture amino acid pathways.	Folic Acid	58-64	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	0-19
23387078-1	2012	Methionine synthase (MS, EC2.1.1.13), a key enzyme in the folate metabolism area catalyzing methyl transfer from N5-methyltetrahydrofolate to homocysteine to give tetrahydrofolate and methionine, takes a core position in folate cycle, one-carbon-unit transfer and sculpture amino acid pathways.	Folic Acid	132-138	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	0-19
22896672-8	2012	This study presents a novel finding of dietary cholesterol, iron, and folic acid predicting PON1 activity in humans and confirms prior reported associations, including that with vitamin C.	Folic Acid	70-80	paraoxonase 1	Homo sapiens	92-96
23059056-8	2012	Three SNPs in tRNA aspartic acid methyltransferase 1 (TRDMT1) gene were associated with total plasma folate levels.	Folic Acid	101-107	tRNA aspartic acid methyltransferase 1	Homo sapiens	54-60
23692788-8	2012	In conclusion, mothers carrying 677TT genotype or with 677CT/1298AC combined genotype have increased risk of having nsCL/P offspring; therefore, higher periconceptional folic acid supplementation should be advised for decreasing the recurrence risk.	Folic Acid	169-179	nescient helix-loop-helix 1	Homo sapiens	116-120
23175323-0	2012	Is there an effect of folic acid supplementation on the coagulation factors and C-reactive protein concentrations in subjects with atherosclerosis risk factors?	Folic Acid	22-32	C-reactive protein	Homo sapiens	80-98
23035307-10	2004	On the basis of the observations described above, folic acid (FA)-conjugated poly(d,l-lactide-coglycolide) (PLGA)-lipid NPs containing ICG at the core (FA-ICG-PLGA-lipid NPs) were fabricated and evaluated for their in vitro targeting characteristics using MCF-7 cells (a human mammary gland adenocarcinoma cell line), which overexpress the folate (FA) receptor (3).	Folic Acid	50-60	folate receptor gamma	Homo sapiens	340-364
22854259-5	2012	Participants without RLS reported higher folate and iron supplement consumption than those with RLS.	Folic Acid	41-47	RLS1	Homo sapiens	21-24
22854259-10	2012	The identification of predictors such as medical comorbidities, and protectors such as folate and iron supplements, is warranted for obstetric RLS.	Folic Acid	87-93	RLS1	Homo sapiens	143-146
23060551-2	2012	This study evaluated the effect of intravenously-administered nitrosylcobalamin (NO-Cbl), a vitamin B12 analog, on serum folate concentrations in healthy dogs.	Folic Acid	121-127	Cbl proto-oncogene	Canis lupus familiaris	84-87
23060551-7	2012	CONCLUSION: Cellular uptake of NO-Cbl, following intravenous administration exerted a biological effect on folate, similar to that previously described for other vitamin B12 analogs.	Folic Acid	107-113	Cbl proto-oncogene	Canis lupus familiaris	34-37
23166529-7	2012	To identify the genetic association with gastric cancer, we selected 17 SNPs sites in folate pathway-associated genes of MTHFR, MTR, and MTRR and tested in 1,261 gastric cancer patients and 375 healthy controls.	Folic Acid	86-92	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	137-141
22887475-2	2012	Further, we evaluated interaction effects between these gene variants and maternal folate intake for risk of CTD.	Folic Acid	83-89	CTD	Homo sapiens	109-112
22869041-12	2012	Conversely, among women with high serum folate levels (n = 53), DNA methylation was positively associated with several immune markers (CD4/CD8 ratio, NK1656/lymphocytes and IgA).	Folic Acid	40-46	CD4 molecule	Homo sapiens	135-138
23166529-3	2012	In the folate pathway, several genes are involved, including methylenetetrahydrofolate reductase (MTHFR), methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR), and methyltetrahydrofolate-homocysteine methyltransferase (MTR).	Folic Acid	7-13	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	171-175
22583576-0	2012	Folate-decorated PLGA nanoparticles as a rationally designed vehicle for the oral delivery of insulin.	Folic Acid	0-6	insulin	Homo sapiens	94-101
22583576-1	2012	AIMS: The present study reports a novel approach for enhancing the oral absorption and hypoglycemic activity of insulin via encapsulation in folate-(FA) coupled polyethylene glycol (PEG)ylated polylactide-co-glycolide (PLGA) nanoparticles (NPs; FA-PEG-PLGA NPs).	Folic Acid	141-147	insulin	Homo sapiens	112-119
22864933-6	2012	This SNP is located upstream of the 5 methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR) gene, and it is known that the enzyme for MTRR is involved in the methionine-folate biosynthesis and metabolism pathway, which is the primary target of 5-FU-related compounds, although the authors were unable to identify a direct relation between rs4702484 and MTRR expression in a tested subset of cells.	Folic Acid	54-60	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	151-155
22782530-9	2012	Folic acid supplementation was associated with decreased urinary 8-iso-PGF(2alpha) and 11-dehydro-TXB2 excretion (p&lt;0.0003) in the hyperhomocysteinaemic group, but not in the control group, with substantial inter-individual variability related to baseline tHcy level and the extent of its reduction.	Folic Acid	0-10	placental growth factor	Homo sapiens	71-74
22704764-6	2012	Misexpression of NMM-IIA/NMM-IIB in the affected placentas continued stably to midgestation but can be prevented by folate and myoinositol supplementation.	Folic Acid	116-122	ATPase, class II, type 9A	Mus musculus	21-24
22864933-6	2012	This SNP is located upstream of the 5 methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR) gene, and it is known that the enzyme for MTRR is involved in the methionine-folate biosynthesis and metabolism pathway, which is the primary target of 5-FU-related compounds, although the authors were unable to identify a direct relation between rs4702484 and MTRR expression in a tested subset of cells.	Folic Acid	54-60	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	151-155
22706675-2	2012	This study tested the hypothesis that maternal folic acid supplementation before or during pregnancy reduces AL risk, accounting for the SNPs rs1801133 (C677T) and rs1801131 (A1298C) in MTHFR and rs1801394 (A66G) and rs1532268 (C524T) in MTRR, assumed to modify folate metabolism.	Folic Acid	47-57	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	238-242
22580371-9	2012	When tissues from these folate-deficient mice were examined, DNMT1 levels were elevated in both the luminal and glandular epithelia, whereas DNMT3A was upregulated in the luminal epithelium and the stroma.	Folic Acid	24-30	DNA methyltransferase (cytosine-5) 1	Mus musculus	61-66
22864933-6	2012	This SNP is located upstream of the 5 methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR) gene, and it is known that the enzyme for MTRR is involved in the methionine-folate biosynthesis and metabolism pathway, which is the primary target of 5-FU-related compounds, although the authors were unable to identify a direct relation between rs4702484 and MTRR expression in a tested subset of cells.	Folic Acid	54-60	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	103-107
22138455-5	2012	METHODS AND MATERIALS: A recombinant ScFv 18-2 derivative was conjugated to folate via a scissile disulfide linker.	Folic Acid	76-82	immunglobulin heavy chain variable region	Homo sapiens	37-41
22138455-10	2012	RESULTS: Human KB and NCI-H292 lung cancer cells treated with folate-conjugated ScFv 18-2 showed significant radiosensitization (p &lt; 0.001).	Folic Acid	62-68	immunglobulin heavy chain variable region	Homo sapiens	80-84
22580371-9	2012	When tissues from these folate-deficient mice were examined, DNMT1 levels were elevated in both the luminal and glandular epithelia, whereas DNMT3A was upregulated in the luminal epithelium and the stroma.	Folic Acid	24-30	DNA methyltransferase 3A	Mus musculus	141-147
22084937-1	2012	In this study, our aim was to investigate the association of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism on the vitamin B12 therapy response in 95 patients with vitamin B12 deficiency and 92 healthy control subjects using vitamin B12, plasma total homocysteine (tHcy), and folate as the main measure of outcome.	Folic Acid	80-86	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	139-142
22693311-2	2012	Unfortunately, folic acid and folate-linked drugs bind equally well to both major isoforms of the FR-that is, FR-alpha, which is primarily expressed on malignant cells, and FR-beta, which is upregulated on activated monocytes and macrophages.	Folic Acid	15-25	rabaptin, RAB GTPase binding effector protein 2	Mus musculus	110-118
22693311-2	2012	Unfortunately, folic acid and folate-linked drugs bind equally well to both major isoforms of the FR-that is, FR-alpha, which is primarily expressed on malignant cells, and FR-beta, which is upregulated on activated monocytes and macrophages.	Folic Acid	30-36	rabaptin, RAB GTPase binding effector protein 2	Mus musculus	110-118
22693311-4	2012	In an effort to develop a targeting ligand that can selectively deliver attached imaging and therapeutic agents to tumor cells, we constructed a reduced and alkylated form of folic acid, N(5), N(10)-dimethyl tetrahydrofolate (DMTHF) that exhibits selectivity for FR-alpha.	Folic Acid	175-185	rabaptin, RAB GTPase binding effector protein 2	Mus musculus	263-271
22461522-0	2012	Folate deprivation enhances invasiveness of human colon cancer cells mediated by activation of sonic hedgehog signaling through promoter hypomethylation and cross action with transcription nuclear factor-kappa B pathway.	Folic Acid	0-6	nuclear factor kappa B subunit 1	Homo sapiens	189-211
22461522-3	2012	The aims of this study were to investigate whether and how folate deprivation promotes invasion by colon cancer cells in relation to Shh signaling and NF-kappaB pathway activation.	Folic Acid	59-65	nuclear factor kappa B subunit 1	Homo sapiens	151-160
22461522-9	2012	Taken together, these findings demonstrate that folate deprivation enhanced invasiveness of colon cancer cells mediated by activation of Shh signaling through promoter hypomethylation and cross actions with the NF-kappaB pathway.	Folic Acid	48-54	nuclear factor kappa B subunit 1	Homo sapiens	211-220
22076974-4	2012	In addition to serving as a neuropeptidase, GCPII catalyzes the absorption of folate.	Folic Acid	78-84	folate hydrolase 1	Mus musculus	44-49
22076974-10	2012	In contrast, all folate-depleted GCPII hypomorphs performed similarly to untreated wild-type mice, suggesting that reduced GCPII expression and folate deficiency are mutually protective.	Folic Acid	17-23	folate hydrolase 1	Mus musculus	33-38
22076974-11	2012	Analyses of folate and neurometabolite levels associated with glutamatergic function suggest several potential mechanisms through which GCPII and folate may be interacting to create this protective effect.	Folic Acid	12-18	folate hydrolase 1	Mus musculus	136-141
22437160-2	2012	The structure of human neuron specific enolase (hNSE) crystals soaked in PGA showed that the enzyme is active in the crystals and produced PEP; conversely soaking in PEP produced PGA.	Folic Acid	73-76	enolase 2	Homo sapiens	23-46
22437160-2	2012	The structure of human neuron specific enolase (hNSE) crystals soaked in PGA showed that the enzyme is active in the crystals and produced PEP; conversely soaking in PEP produced PGA.	Folic Acid	179-182	enolase 2	Homo sapiens	23-46
22946297-1	2012	The work is dedicated to creation of the mathematical model of folate-dependent one-carbon unit metabolism (FOCM) and study of its function in human placenta under homocysteine load and the most common mutations in the genes of methylenetetrahydrofolate reductase (MTHFR) and cystathionine beta-synthase (CBS).	Folic Acid	63-69	cystathionine beta-synthase	Homo sapiens	276-303
22663302-3	2012	Nevertheless, 1 reacts with (en)Pd(II) (en = ethylenediamine) to give preferentially the dinuclear complex [Pt(2,2"-bpy)(1-MeC(-)-N3,N4)(2)Pd(en)](NO(3))(2) 5H(2)O (2) with head-head arranged 1-methylctosinato (1-MeC(-)) ligands and Pd being coordinated to two exocyclic N4H(-) positions.	Folic Acid	133-135	C-C motif chemokine ligand 28	Homo sapiens	213-216
22484375-6	2012	The elevate expression of dihydrofolate reductase and thymidylate synthase, two E2F1-target genes involved in folate metabolism and required for G(1) progression, favored dTTP accumulation, which promoted DNA single strand breaks and the subsequent activation of Chk1.	Folic Acid	33-39	checkpoint kinase 1	Homo sapiens	263-267
22521626-2	2012	Methylenetetrahydrofolate reductase (MTHFR) generates the primary circulatory form of folate required for homocysteine remethylation to methionine.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Mus musculus	37-42
22415298-6	2012	Follow up of these children revealed that higher maternal folate in pregnancy predicted higher adiposity and insulin resistance at 6 years of age.	Folic Acid	58-64	insulin	Homo sapiens	109-116
22415298-7	2012	The most insulin resistant children were born to mothers who were vitamin B(12) deficient and had high folate concentrations.	Folic Acid	103-109	insulin	Homo sapiens	9-16
22310383-13	2012	However, a positive correlation was seen between plasma folate levels and GCPII expression (r=0.70, p&lt;0.05).	Folic Acid	56-62	folate hydrolase 1	Homo sapiens	74-79
22566245-4	2012	Data generated indicated that folic acid and vitamin B12 separately or in combination can give significant protection against alterations in oxidative stress and apoptotic marker parameters and downstream changes in mitochondria, namely pro-oxidative (NO, TBARS, OH-) and antioxidative defense (SOD, CAT, GSH) markers, iNOS protein expression, mitochondrial swelling, cytochrome c oxidase and Ca2+-ATPase activity, Ca2+ content, caspase-3 activity.	Folic Acid	30-40	catalase	Rattus norvegicus	300-303
22566245-4	2012	Data generated indicated that folic acid and vitamin B12 separately or in combination can give significant protection against alterations in oxidative stress and apoptotic marker parameters and downstream changes in mitochondria, namely pro-oxidative (NO, TBARS, OH-) and antioxidative defense (SOD, CAT, GSH) markers, iNOS protein expression, mitochondrial swelling, cytochrome c oxidase and Ca2+-ATPase activity, Ca2+ content, caspase-3 activity.	Folic Acid	30-40	nitric oxide synthase 2	Rattus norvegicus	319-323
22248732-3	2012	BCRP also plays a key role in heme and folate homeostasis, which may help normal cells survive under conditions of hypoxia.	Folic Acid	39-45	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	0-4
22545497-5	2012	In case of TNF-receptor associated periodic syndrome (TRAPS) and paediatric granulomatous arthritis (PGA), TNF-antagonists may also be used; in familial Mediterranean fever (FMF) colchicine remains the first choice.	Folic Acid	101-104	tumor necrosis factor	Homo sapiens	107-110
22236648-0	2012	Polymorphisms in the folate-metabolizing genes MTR, MTRR, and CBS and breast cancer risk.	Folic Acid	21-27	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	52-56
22234787-6	2012	RESULTS: The angiogenic to antiangiogenic ratio [PlGF/(sFlt-1 x sEng)] was positively related to intake of vitamin D (r = 0.24), vitamin B(2) (r = 0.25), B(12) (r = 0.20), dietary folate equivalents (r = 0.19), iron (r = 0.19), and zinc (r = 0.19) and negatively related to transfats (r = -0.24).	Folic Acid	180-186	placental growth factor	Homo sapiens	49-53
22236648-2	2012	The aim of our study was to investigate the association of three single-nucleotide polymorphisms (SNPs) in the folate-metabolizing genes - A2756G MTR, A66G MTRR, and 844ins68 CBS - which have putative functional significance in breast cancer risk.	Folic Acid	111-117	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	156-160
22344247-11	2012	In univariate analyses, clinical variables including sex, age, and folate supplementation in addition to variations in MTHFR, MTR, and SLC25A32 were associated with differential intracellular folate redox concentrations.	Folic Acid	192-198	solute carrier family 25 member 32	Homo sapiens	135-143
21986714-11	2012	Folic acid supplementation of the maternal diet was associated with reduced expression of PPARalpha, PPARgamma, and LXRalpha in the liver (P &lt; 0.001).	Folic Acid	0-10	nuclear receptor subfamily 1, group H, member 3	Rattus norvegicus	116-124
21986714-17	2012	Furthermore, the expression of LXRalpha, PPARalpha, and PPARgamma in the liver and adipose tissue largely depends on the protein and folic acid content in the maternal diet during gestation.	Folic Acid	133-143	nuclear receptor subfamily 1, group H, member 3	Rattus norvegicus	31-39
26105097-2	2012	In addition there are a number of ATP-dependent transporters which have also recently been shown to be involved in folate transport; these include ABCB1, ABCC2 and BCRP (ABCG2).	Folic Acid	115-121	ATP binding cassette subfamily B member 1	Homo sapiens	147-152
26105097-2	2012	In addition there are a number of ATP-dependent transporters which have also recently been shown to be involved in folate transport; these include ABCB1, ABCC2 and BCRP (ABCG2).	Folic Acid	115-121	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	164-168
26105097-2	2012	In addition there are a number of ATP-dependent transporters which have also recently been shown to be involved in folate transport; these include ABCB1, ABCC2 and BCRP (ABCG2).	Folic Acid	115-121	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	170-175
22400137-14	2004	PSMA may play an important role in the progression of prostate cancer and glutamatergic neurotransmission, as well as in the absorption of folate (10).	Folic Acid	139-145	folate hydrolase 1	Homo sapiens	0-4
23007063-5	2012	Folate supplementation with or without serine significantly increased or tended to increase hepatic 5-methyltetrahydrofolate concentration together with methionine synthase (MS) and cystathionine beta-synthase (CBS) activities and MS mRNA level in both rats fed 10C and rats fed 25S.	Folic Acid	0-6	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	231-233
22611939-0	2012	[Folic acid prevents Bcl-2 hypomethylation in rats with hyperhomocysteinemia].	Folic Acid	1-11	BCL2, apoptosis regulator	Rattus norvegicus	21-26
22611939-1	2012	OBJECTIVE: To investigate the effects of folic acid on Bcl-2 gene methylation status in rats with hyperhomocystinemia induced by ingestion of excess methionine.	Folic Acid	41-51	BCL2, apoptosis regulator	Rattus norvegicus	55-60
22611939-13	2012	CONCLUSIONS: Folic acid supplementation can prevents Bcl-2 hypomethylation in rats with hyperhomocysteinemia, resulting in a decreased Bcl-2 expression.	Folic Acid	13-23	BCL2, apoptosis regulator	Rattus norvegicus	53-58
22611939-13	2012	CONCLUSIONS: Folic acid supplementation can prevents Bcl-2 hypomethylation in rats with hyperhomocysteinemia, resulting in a decreased Bcl-2 expression.	Folic Acid	13-23	BCL2, apoptosis regulator	Rattus norvegicus	135-140
22379638-4	2004	PSMA may play an important role in the progression of prostate cancer and glutamatergic neurotransmission, as well as in the absorption of folate (4).	Folic Acid	139-145	folate hydrolase 1	Homo sapiens	0-4
21934042-10	2012	These results were in accord with a mathematical model of folate metabolism, which predicted that reduction in methionine synthase activity would cause increased formate levels, whereas reduced cystathionine beta-synthase activity would not.	Folic Acid	58-64	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	111-130
21934042-10	2012	These results were in accord with a mathematical model of folate metabolism, which predicted that reduction in methionine synthase activity would cause increased formate levels, whereas reduced cystathionine beta-synthase activity would not.	Folic Acid	58-64	cystathionine beta synthase	Rattus norvegicus	194-221
21956163-3	2012	Transport of folate from the cytoplasm into the mitochondria is via a specific carrier-mediated process involving the mitochondrial folate transporter (MFT).	Folic Acid	13-19	solute carrier family 25 member 32	Homo sapiens	118-150
21956163-3	2012	Transport of folate from the cytoplasm into the mitochondria is via a specific carrier-mediated process involving the mitochondrial folate transporter (MFT).	Folic Acid	13-19	solute carrier family 25 member 32	Homo sapiens	152-155
21956163-8	2012	Similarly, chronic alcohol exposure (96 h) of HepG2 cells led to significant inhibition in mitochondrial carrier-mediated folate uptake, which was associated with a marked reduction in the level of expression of the human MFT (hMFT).	Folic Acid	122-128	solute carrier family 25 member 32	Homo sapiens	222-225
21956163-8	2012	Similarly, chronic alcohol exposure (96 h) of HepG2 cells led to significant inhibition in mitochondrial carrier-mediated folate uptake, which was associated with a marked reduction in the level of expression of the human MFT (hMFT).	Folic Acid	122-128	solute carrier family 25 member 32	Homo sapiens	227-231
21956163-10	2012	These studies show for the first time that chronic alcohol feeding/exposure leads to a significant inhibition in mitochondrial carrier-mediated folate uptake and that the inhibition is, in part, being exerted at the level of transcription of the SLC25A32 gene.	Folic Acid	144-150	solute carrier family 25 member 32	Homo sapiens	246-254
23244153-1	2012	AIM: The present case-control study was conducted to explore the association of MTHFR gene polymorphism and relations of P16, MGMT and HMLH1 to MTHFR and folate intake.	Folic Acid	154-160	cyclin dependent kinase inhibitor 2A	Homo sapiens	121-124
22377700-5	2012	The polymorphisms MTHFR c.677C&gt;T and solute carrier family 19 (folate transporter), member 1 (SLC19A1) c.80 A&gt;G modulate folate concentrations, whereas the 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR) c.66A&gt;G polymorphism affects the MMA concentration.	Folic Acid	66-72	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	162-227
22377700-5	2012	The polymorphisms MTHFR c.677C&gt;T and solute carrier family 19 (folate transporter), member 1 (SLC19A1) c.80 A&gt;G modulate folate concentrations, whereas the 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR) c.66A&gt;G polymorphism affects the MMA concentration.	Folic Acid	66-72	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	229-233
22489220-0	2012	Enhancement of the folate content in Egyptian pita bread.	Folic Acid	19-25	disease resistance protein RGA5	Triticum aestivum	46-50
22489220-2	2012	One major food source for folate is pita (baladi) bread, which is consumed daily.	Folic Acid	26-32	disease resistance protein RGA5	Triticum aestivum	36-40
22489220-4	2012	The aim was to produce pita bread with increased folate content using germinated wheat flour (GWF).	Folic Acid	49-55	disease resistance protein RGA5	Triticum aestivum	23-27
22489220-10	2012	Pita bread baked with 50% sieved GWF was acceptable with respect to colour and layer separation, and had a folate content of 50 microg/100 g DM compared with 30 microg/100 g DM in conventional pita bread (0% GWF).	Folic Acid	107-113	disease resistance protein RGA5	Triticum aestivum	0-4
22489220-11	2012	CONCLUSION: Using 50% GWF, pita bread with increased folate content, acceptable for the Egyptian consumer, was produced.	Folic Acid	53-59	disease resistance protein RGA5	Triticum aestivum	27-31
22083158-10	2012	Intriguingly, restoration of dihydrofolate reductase expression by oral administration of folic acid or overexpression of dihydrofolate reductase completely prevented AAA formation in Ang II-infused hph-1 mice while attenuating progressive uncoupling of eNOS.	Folic Acid	90-100	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	184-190
22101525-4	2012	To test the hypothesis that an imbalance in MMP-to-TIMP ratio leads to interstitial fibrosis and RVF and whether the treatment with folic acid (FA) alleviates ROS generation, maintains MMP/TIMP balance, and regresses interstitial fibrosis, we used a mouse model of pulmonary artery constriction (PAC).	Folic Acid	132-142	tissue inhibitor of metalloproteinase 1	Mus musculus	189-193
22061491-4	2012	Delivery of BCL-2 siRNA using the folate-targeted nanocarrier can effectively suppress the anti-apoptotic response and sensitized C6 cells to DOX treatment both in vitro and in vivo.	Folic Acid	34-40	BCL2, apoptosis regulator	Rattus norvegicus	12-17
22061491-5	2012	In particular, animal studies using the in situ rat C6 glioma model showed that the folate-targeted co-delivery of BCL-2 siRNA and DOX caused not only an obvious down-regulation of the anti-apoptotic BCL-2 gene but also a remarkable up-regulation of the pro-apoptotic Bax gene, resulting in the significantly elevated level of caspase-3 activation and remarkable cell apoptosis in tumor tissues.	Folic Acid	84-90	BCL2, apoptosis regulator	Rattus norvegicus	115-120
22061491-5	2012	In particular, animal studies using the in situ rat C6 glioma model showed that the folate-targeted co-delivery of BCL-2 siRNA and DOX caused not only an obvious down-regulation of the anti-apoptotic BCL-2 gene but also a remarkable up-regulation of the pro-apoptotic Bax gene, resulting in the significantly elevated level of caspase-3 activation and remarkable cell apoptosis in tumor tissues.	Folic Acid	84-90	BCL2, apoptosis regulator	Rattus norvegicus	200-205
21872972-10	2012	In addition, folic acid had a protective effect in the NOS3 786 TT and NOS3 894 GT + TT genotype.	Folic Acid	13-23	nitric oxide synthase 3	Homo sapiens	55-59
21872972-10	2012	In addition, folic acid had a protective effect in the NOS3 786 TT and NOS3 894 GT + TT genotype.	Folic Acid	13-23	nitric oxide synthase 3	Homo sapiens	71-75
22100631-0	2012	Alcohol intake and folate antagonism via CYP2E1 and ALDH1: effects on oral carcinogenesis.	Folic Acid	19-25	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	41-47
22100631-8	2012	Studies using liver cells have demonstrated that S-adenosyl methionine (SAM), which is a product of folate metabolism, regulates the expression and catalytic activity of CYP2E1.	Folic Acid	100-106	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	170-176
22100631-9	2012	Our first hypothesis is that as increased levels of folate lead to higher concentrations of SAM, SAM antagonizes the expression of CYP2E1, which results in decreased conversion of ethanol into acetaldehyde.	Folic Acid	52-58	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	131-137
22100631-13	2012	The second, ALDH1L1, also known as FDH, is required for DNA nucleotide biosynthesis, and is upregulated at high concentrations of folate.	Folic Acid	130-136	aldehyde dehydrogenase 1 family member L1	Homo sapiens	12-19
22100631-13	2012	The second, ALDH1L1, also known as FDH, is required for DNA nucleotide biosynthesis, and is upregulated at high concentrations of folate.	Folic Acid	130-136	aldehyde dehydrogenase 1 family member L1	Homo sapiens	35-38
22100631-16	2012	Our second hypothesis is that folate interacts with one of these response elements to upregulate ALDH1A1 and ALDH1L1 expression in order to decrease acetaldehyde concentrations and promote DNA stability, thereby decreasing cancer susceptibility.	Folic Acid	30-36	aldehyde dehydrogenase 1 family member L1	Homo sapiens	109-116
21521032-0	2012	Fetal neural tube stem cells from Pax3 mutant mice proliferate, differentiate, and form synaptic connections when stimulated with folic acid.	Folic Acid	130-140	paired box 3	Mus musculus	34-38
21957013-3	2012	The protective effect provided by FA suggests that the genes involved in folate metabolism, such as cystathionine beta-synthase (CBS), warrant further investigation.	Folic Acid	73-79	cystathionine beta-synthase	Homo sapiens	100-127
21957013-3	2012	The protective effect provided by FA suggests that the genes involved in folate metabolism, such as cystathionine beta-synthase (CBS), warrant further investigation.	Folic Acid	73-79	cystathionine beta-synthase	Homo sapiens	129-132
22112349-8	2012	These strategies include targeting NO synthesis by modulation of endothelial nitric oxide synthase (eNOS) coupling, such as folates and tetrahydrobiopterin.	Folic Acid	124-131	nitric oxide synthase 3	Homo sapiens	65-98
22848173-6	2012	METHODS AND RESULTS: Intravenous administration of folate-targeted, paclitaxel-loaded micelles was demonstrated to be more efficient in inhibiting subcutaneous xenograft tumors and extending the survival rate of tumor-bearing nude mice than free paclitaxel and plain paclitaxel micelles at an equivalent paclitaxel dose of 20 mg/kg, which was further backed up by flow cytometry, TUNEL, and expression of apoptosis-related proteins, including Bax, Bcl2, and caspase 3 in this study.	Folic Acid	51-57	B cell leukemia/lymphoma 2	Mus musculus	448-452
22888237-4	2012	Upon the codelivery of siRNA, targeting the Bcl-2 gene, and DOX, using the folate-targeted nanocarrier, DOX-induced apoptosis in the skov-3 cells overexpressing folate receptor was significantly enhanced through a mechanism of downregulating the antiapoptotic protein Bcl-2, while simultaneously upregulating the proapoptotic protein Bax.	Folic Acid	75-81	BCL2 apoptosis regulator	Homo sapiens	44-49
22888237-4	2012	Upon the codelivery of siRNA, targeting the Bcl-2 gene, and DOX, using the folate-targeted nanocarrier, DOX-induced apoptosis in the skov-3 cells overexpressing folate receptor was significantly enhanced through a mechanism of downregulating the antiapoptotic protein Bcl-2, while simultaneously upregulating the proapoptotic protein Bax.	Folic Acid	75-81	BCL2 apoptosis regulator	Homo sapiens	268-273
22888237-4	2012	Upon the codelivery of siRNA, targeting the Bcl-2 gene, and DOX, using the folate-targeted nanocarrier, DOX-induced apoptosis in the skov-3 cells overexpressing folate receptor was significantly enhanced through a mechanism of downregulating the antiapoptotic protein Bcl-2, while simultaneously upregulating the proapoptotic protein Bax.	Folic Acid	75-81	BCL2 associated X, apoptosis regulator	Homo sapiens	334-337
22064069-5	2012	Following adjustment for APOE4 status, education level, and age at blood draw, subjects with the highest blood folate levels had a higher likelihood of being in the APSYMAD group as compared to the demented (AD) group (odds ratio = 1.09, 95% CI = 1.00-1.18. p < 0.06).	Folic Acid	111-117	apolipoprotein E	Homo sapiens	25-30
23328702-2	2012	We determined whether supplementation with physiological doses of folate could alter methylation in the oestrogen receptor 1 (ESR1) and mutL homolog 1 (MLH1) genes in colonic mucosa of subjects with colorectal adenoma.	Folic Acid	66-72	estrogen receptor 1	Homo sapiens	126-130
25825305-5	2012	Poor folate and vitamin B12 status short of clinical deficiency is associated with increased risk of cognitive impairment, depression, Alzheimer"s disease and stroke among older adults and increased risk of neural tube defects among children born to mothers with low folate status.	Folic Acid	267-273	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	24-27
22777156-0	2012	4-1BB-mediated signals confer protection against folic acid-induced nephrotoxicity.	Folic Acid	49-59	tumor necrosis factor receptor superfamily, member 9	Mus musculus	0-5
22790564-6	2012	Folate deprivation markedly increased the hepatic concentration of N,N-dimethylglycine (DMG), a known inhibitor of BHMT, and there was a significant positive correlation between hepatic DMG concentration and plasma homocysteine concentration, suggesting that folate deficiency increases hepatic DMG concentration and thereby depresses BHMT reaction, leading to interference with the effect of betaine supplementation.	Folic Acid	0-6	betaine-homocysteine S-methyltransferase	Rattus norvegicus	115-119
22790564-10	2012	These results support the concept that folate deficiency impairs homocysteine metabolism not only by the MS pathway but also by the BHMT pathway.	Folic Acid	39-45	betaine-homocysteine S-methyltransferase	Rattus norvegicus	132-136
25825305-9	2012	Several observations of unfavorable health indicators in children and adults exposed to high folic acid intake make it imperative to achieve a more precise definition of folate and B12 requirements for brain development and function.	Folic Acid	93-103	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	181-184
23137028-6	2012	Upregulation of DNA damage repair genes Apurinic/apyrimidinic endonuclease 1, X-ray repair complementing defective repair in Chinese hamster cells 5, 8-oxoguanine-DNA glycosylase, and proliferating cell nuclear antigen, associated with a reduction of folic acid level was observed in colons of DMH group.	Folic Acid	251-261	N-glycosylase/DNA lyase	Cricetulus griseus	150-178
22519865-5	2012	The statistical significance of this effect modification was further studied using an interaction model, where only folate was observed to have an influence on B12 levels as suggested by the odds ratio of 7.11 (95% CI = 0.45 to 111.9) obtained for ICC group, implicating a synergistic role of these 2 vitamins in invasive cervical cancer.	Folic Acid	116-122	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	160-163
23152928-3	2012	Cystathionine-beta-synthase (CBS) functions in the folate metabolism pathway, which is intricately linked to methylation of genomic DNA.	Folic Acid	51-57	cystathionine beta-synthase	Homo sapiens	0-27
23152928-3	2012	Cystathionine-beta-synthase (CBS) functions in the folate metabolism pathway, which is intricately linked to methylation of genomic DNA.	Folic Acid	51-57	cystathionine beta-synthase	Homo sapiens	29-32
23152928-13	2012	CONCLUSION: A novel finding from this study is that the folate metabolism enzyme CBS mRNA levels are frequently downregulated through CpG methylation of the CBS gene in gastric cancer and CRC, suggesting that CBS functions as a tumor suppressor gene.	Folic Acid	56-62	cystathionine beta-synthase	Homo sapiens	81-84
23152928-13	2012	CONCLUSION: A novel finding from this study is that the folate metabolism enzyme CBS mRNA levels are frequently downregulated through CpG methylation of the CBS gene in gastric cancer and CRC, suggesting that CBS functions as a tumor suppressor gene.	Folic Acid	56-62	cystathionine beta-synthase	Homo sapiens	157-160
23152928-13	2012	CONCLUSION: A novel finding from this study is that the folate metabolism enzyme CBS mRNA levels are frequently downregulated through CpG methylation of the CBS gene in gastric cancer and CRC, suggesting that CBS functions as a tumor suppressor gene.	Folic Acid	56-62	cystathionine beta-synthase	Homo sapiens	157-160
22116698-10	2012	Folates interact with the endothelial enzyme NO synthase (eNOS) and, exert effects on the cofactor bioavailability of NO and thus, on peroxynitrite formation.	Folic Acid	0-7	nitric oxide synthase 3	Homo sapiens	58-62
23794298-8	2012	Malondialdehyde concentration significantly decreased and superoxide dismutase activity increased in the 2 mg/kg folic acid pre-treated group, while 3 mg/kg folic acid significantly increased the malondialdehyde concentration and decreased both catalase and superoxide dismutase.	Folic Acid	113-123	catalase	Rattus norvegicus	245-253
23794298-8	2012	Malondialdehyde concentration significantly decreased and superoxide dismutase activity increased in the 2 mg/kg folic acid pre-treated group, while 3 mg/kg folic acid significantly increased the malondialdehyde concentration and decreased both catalase and superoxide dismutase.	Folic Acid	157-167	catalase	Rattus norvegicus	245-253
21640799-11	2011	In conclusion, the results of this study show that folic acid can protect against dexamethasone-induced neurotoxicity and its protective mechanism is related to a signaling pathway that involves PI3K/Akt, CaMKII, and PKA.	Folic Acid	51-61	AKT serine/threonine kinase 1	Homo sapiens	200-203
21769670-1	2011	Methylenetetrahydrofolate reductase (MTHFR), a key enzyme in folate metabolism, synthesizes 5-methyltetrahydrofolate, the main circulatory form of folate which is required for maintaining nontoxic levels of homocysteine and providing one-carbon units for methylation.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Mus musculus	37-42
21769670-1	2011	Methylenetetrahydrofolate reductase (MTHFR), a key enzyme in folate metabolism, synthesizes 5-methyltetrahydrofolate, the main circulatory form of folate which is required for maintaining nontoxic levels of homocysteine and providing one-carbon units for methylation.	Folic Acid	61-67	methylenetetrahydrofolate reductase	Mus musculus	0-35
21769670-1	2011	Methylenetetrahydrofolate reductase (MTHFR), a key enzyme in folate metabolism, synthesizes 5-methyltetrahydrofolate, the main circulatory form of folate which is required for maintaining nontoxic levels of homocysteine and providing one-carbon units for methylation.	Folic Acid	61-67	methylenetetrahydrofolate reductase	Mus musculus	37-42
21873667-7	2011	Folate signaling appears to be unique for TAA at 1 week (Folh1, Cubn), whereas aryl-hydrocarbon receptor signaling might be important for both steroids at 1 month postinjection.	Folic Acid	0-6	folate hydrolase 1	Mus musculus	57-62
21930702-0	2011	Incrimination of heterogeneous nuclear ribonucleoprotein E1 (hnRNP-E1) as a candidate sensor of physiological folate deficiency.	Folic Acid	110-116	poly(rC) binding protein 1	Homo sapiens	17-59
21930702-0	2011	Incrimination of heterogeneous nuclear ribonucleoprotein E1 (hnRNP-E1) as a candidate sensor of physiological folate deficiency.	Folic Acid	110-116	poly(rC) binding protein 1	Homo sapiens	61-69
21930702-2	2011	Because homocysteine, which accumulates intracellularly during folate deficiency, stimulated interactions between heterogeneous nuclear ribonucleoprotein E1 (hnRNP-E1) and an 18-base FR-alpha mRNA cis-element that led to increased FR biosynthesis and net up-regulation of FR at cell surfaces, hnRNP-E1 was a plausible candidate sensor of folate deficiency.	Folic Acid	63-69	poly(rC) binding protein 1	Homo sapiens	114-156
21930702-2	2011	Because homocysteine, which accumulates intracellularly during folate deficiency, stimulated interactions between heterogeneous nuclear ribonucleoprotein E1 (hnRNP-E1) and an 18-base FR-alpha mRNA cis-element that led to increased FR biosynthesis and net up-regulation of FR at cell surfaces, hnRNP-E1 was a plausible candidate sensor of folate deficiency.	Folic Acid	63-69	poly(rC) binding protein 1	Homo sapiens	158-166
21930702-2	2011	Because homocysteine, which accumulates intracellularly during folate deficiency, stimulated interactions between heterogeneous nuclear ribonucleoprotein E1 (hnRNP-E1) and an 18-base FR-alpha mRNA cis-element that led to increased FR biosynthesis and net up-regulation of FR at cell surfaces, hnRNP-E1 was a plausible candidate sensor of folate deficiency.	Folic Acid	63-69	poly(rC) binding protein 1	Homo sapiens	293-301
21930702-2	2011	Because homocysteine, which accumulates intracellularly during folate deficiency, stimulated interactions between heterogeneous nuclear ribonucleoprotein E1 (hnRNP-E1) and an 18-base FR-alpha mRNA cis-element that led to increased FR biosynthesis and net up-regulation of FR at cell surfaces, hnRNP-E1 was a plausible candidate sensor of folate deficiency.	Folic Acid	338-344	poly(rC) binding protein 1	Homo sapiens	114-156
21930702-2	2011	Because homocysteine, which accumulates intracellularly during folate deficiency, stimulated interactions between heterogeneous nuclear ribonucleoprotein E1 (hnRNP-E1) and an 18-base FR-alpha mRNA cis-element that led to increased FR biosynthesis and net up-regulation of FR at cell surfaces, hnRNP-E1 was a plausible candidate sensor of folate deficiency.	Folic Acid	338-344	poly(rC) binding protein 1	Homo sapiens	158-166
21930702-8	2011	Collectively, such data incriminate hnRNP-E1 as a physiologically relevant, sensitive, cellular sensor of folate deficiency.	Folic Acid	106-112	poly(rC) binding protein 1	Homo sapiens	36-44
22345769-0	2011	STUDY OF THE ROLE OF SERUM FOLIC ACID IN ATOPIC DERMATITIS: A CORRELATION WITH SERUM IgE AND DISEASE SEVERITY.	Folic Acid	27-37	immunoglobulin heavy constant epsilon	Homo sapiens	85-88
22097960-1	2011	Human methionine synthase reductase (MSR), a diflavin oxidoreductase, plays a vital role in methionine and folate metabolism by sustaining methionine synthase (MS) activity.	Folic Acid	107-113	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	6-35
22097960-1	2011	Human methionine synthase reductase (MSR), a diflavin oxidoreductase, plays a vital role in methionine and folate metabolism by sustaining methionine synthase (MS) activity.	Folic Acid	107-113	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	37-40
21971371-5	2011	It is concluded that folic acid produced antidepressant-like effects probably through the participation of the NPY Y1 receptors found in the lateral septal nuclei.	Folic Acid	21-31	neuropeptide Y	Rattus norvegicus	111-114
21982484-1	2011	PURPOSE: To investigate the potential interaction between folate intake and the paraoxonase 1 (PON1) Q192R polymorphism with the risk of incident coronary heart disease (CHD) and ischemic stroke in the Atherosclerosis Risk in Communities study, a population-based prospective cohort of cardiovascular disease in 15,792 white and African-American subject.	Folic Acid	58-64	paraoxonase 1	Homo sapiens	95-99
21982484-2	2011	METHODS: Race-stratified Cox proportional hazards models were performed to examine the interaction between folate intake and the PON1 Q192R polymorphism.	Folic Acid	107-113	paraoxonase 1	Homo sapiens	129-133
21982484-5	2011	CONCLUSIONS: There was an interaction between folate intake and PON1 Q192 polymorphism with regard to the risk of ischemic stroke in white subjects.	Folic Acid	46-52	paraoxonase 1	Homo sapiens	64-68
21836022-5	2011	Strikingly, mild dietary folate depletion arrested prostate cancer progression in 25 of 26 transgenic adenoma of the mouse prostate (TRAMP) mice, in which tumorigenesis is prostate-specific and characteristically aggressive.	Folic Acid	25-31	tumor necrosis factor receptor superfamily, member 25	Mus musculus	133-138
21770049-8	2011	Low folate reduced overall methylation of Slc394a by 3.4% (p=0.038) but did not affect Esr1 or Igf2 differentially methylated region (DMR) 1.	Folic Acid	4-10	chemokine (C-C motif) ligand 21A (serine)	Mus musculus	42-45
21803942-9	2011	CSQ2 expression was reduced in mice fed a diet low in the methyl donor folic acid and in cells treated with 5-azadeoxycytidine suggesting an involvement of DNA methylation.	Folic Acid	71-81	calsequestrin 2	Mus musculus	0-4
21528358-0	2011	Folic acid inhibits lipopolysaccharide-induced inflammatory response in RAW264.7 macrophages by suppressing MAPKs and NF-kappaB activation.	Folic Acid	0-10	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	118-127
21748308-7	2011	Levels of maternal folate intake modified associations with SNPs in CBS, MTRR, and TYMS.	Folic Acid	19-25	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	73-77
22013722-12	2011	CONCLUSIONS: In this study, the increased level of tissue MDA and serum TNF-alpha level together may be suggested that the underlying mechanism is related to direct toxicity of MTX rather than blockage in folate synthesis in kidneys.	Folic Acid	205-211	tumor necrosis factor	Rattus norvegicus	72-81
21528358-7	2011	Further study showed that folic acid inhibited the LPS-induced phosphorylation of MAPKs and the nuclear translocation of NF-kappaB.	Folic Acid	26-36	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	121-130
21528358-8	2011	CONCLUSION: Folic acid inhibits the inflammatory response of RAW 264.7 cells to LPS through inhibiting the MAPKs and NF-kappaB pathways.	Folic Acid	12-22	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	117-126
21528358-6	2011	RESULTS: Folic acid inhibited LPS-induced production of NO, TNF-alpha and IL-1beta with decreased mRNAs of inducible nitric oxide synthase (iNOS), TNF-alpha and IL-1beta.	Folic Acid	9-19	tumor necrosis factor	Mus musculus	60-69
21528358-6	2011	RESULTS: Folic acid inhibited LPS-induced production of NO, TNF-alpha and IL-1beta with decreased mRNAs of inducible nitric oxide synthase (iNOS), TNF-alpha and IL-1beta.	Folic Acid	9-19	interleukin 1 beta	Mus musculus	74-82
21528358-6	2011	RESULTS: Folic acid inhibited LPS-induced production of NO, TNF-alpha and IL-1beta with decreased mRNAs of inducible nitric oxide synthase (iNOS), TNF-alpha and IL-1beta.	Folic Acid	9-19	nitric oxide synthase 2, inducible	Mus musculus	107-138
21528358-6	2011	RESULTS: Folic acid inhibited LPS-induced production of NO, TNF-alpha and IL-1beta with decreased mRNAs of inducible nitric oxide synthase (iNOS), TNF-alpha and IL-1beta.	Folic Acid	9-19	nitric oxide synthase 2, inducible	Mus musculus	140-144
21528358-6	2011	RESULTS: Folic acid inhibited LPS-induced production of NO, TNF-alpha and IL-1beta with decreased mRNAs of inducible nitric oxide synthase (iNOS), TNF-alpha and IL-1beta.	Folic Acid	9-19	tumor necrosis factor	Mus musculus	147-156
21528358-6	2011	RESULTS: Folic acid inhibited LPS-induced production of NO, TNF-alpha and IL-1beta with decreased mRNAs of inducible nitric oxide synthase (iNOS), TNF-alpha and IL-1beta.	Folic Acid	9-19	interleukin 1 beta	Mus musculus	161-169
21813566-0	2011	Novel inborn error of folate metabolism: identification by exome capture and sequencing of mutations in the MTHFD1 gene in a single proband.	Folic Acid	22-28	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	108-114
22022004-7	2011	Pre-treatment with folic acid prevented the formation of ulcers by 32%, and attenuated the inhibition of mucus by 14%, CAT, 51% and SOD, 150%.	Folic Acid	19-29	catalase	Rattus norvegicus	119-122
21813566-3	2011	RESULTS: Two mutations were identified in the MTHFD1 gene, which encodes a protein that catalyses three reactions involved in cellular folate metabolism.	Folic Acid	135-141	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	46-52
21647593-7	2011	In wild-type (gp91(+/+)) mice, hHcys induced by a folate-free diet markedly enhanced expression of mesenchymal markers (FSP-1 and alpha-SMA) but decreased expression of epithelial markers of podocytes in glomeruli, which were not observed in gp91(-/-) mouse glomeruli.	Folic Acid	50-56	S100 calcium binding protein A4	Mus musculus	120-125
21697809-7	2011	To minimize the harmful (including fatal) consequences of EPO resistance, surveillance programs must replenish nutrient (for example, iron and folate) stores, minimize oxidative hemolysis, control hyperparathyroidism, avoid catheter infection, and optimize uremic clearance.	Folic Acid	143-149	erythropoietin	Homo sapiens	58-61
21647593-7	2011	In wild-type (gp91(+/+)) mice, hHcys induced by a folate-free diet markedly enhanced expression of mesenchymal markers (FSP-1 and alpha-SMA) but decreased expression of epithelial markers of podocytes in glomeruli, which were not observed in gp91(-/-) mouse glomeruli.	Folic Acid	50-56	actin alpha 2, smooth muscle, aorta	Mus musculus	130-139
21709613-5	2011	The association persisted when serum B12 and folate levels were controlled for (r = -0.308).	Folic Acid	45-51	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	37-40
21108044-6	2011	Real-time PCR indicated that gene expression of MAT1A, MAT2A and DNMT1 were lower in IUGR piglets but could be elevated by maternal folic acid supplementation.	Folic Acid	132-142	methionine adenosyltransferase 2A	Homo sapiens	55-60
21108044-7	2011	Transcript expression levels of PPARgamma, GR and AOX were higher in IUGR piglets, but were decreased to the level of normal piglets by maternal folic acid supplementation.	Folic Acid	145-155	peroxisome proliferator activated receptor gamma	Homo sapiens	32-41
21108044-7	2011	Transcript expression levels of PPARgamma, GR and AOX were higher in IUGR piglets, but were decreased to the level of normal piglets by maternal folic acid supplementation.	Folic Acid	145-155	nuclear receptor subfamily 3 group C member 1	Homo sapiens	43-45
21802161-1	2011	AIMS: This study performed to determine the effects of folate supplementation on indices of glycemic control, insulin resistance and lipid profile in overweight and obese men with type 2 diabetes under metformin (at least 1500 mg daily) treatment.	Folic Acid	55-61	insulin	Homo sapiens	110-117
21802161-6	2011	RESULTS: Supplementation with folic acid led to 8% decrease in HbA1C (p=0.048), 7.5% in fasting blood glucose (p=0.051), 16.2% in serum insulin (p=0.021), 20.5% in insulin resistance (p=0.041) and 21.2% in plasma homocysteine (p=0.000).	Folic Acid	30-40	insulin	Homo sapiens	136-143
21802161-6	2011	RESULTS: Supplementation with folic acid led to 8% decrease in HbA1C (p=0.048), 7.5% in fasting blood glucose (p=0.051), 16.2% in serum insulin (p=0.021), 20.5% in insulin resistance (p=0.041) and 21.2% in plasma homocysteine (p=0.000).	Folic Acid	30-40	insulin	Homo sapiens	164-171
21802161-9	2011	CONCLUSIONS: Folic acid supplementation lowered plasma level of homocysteine, improved glycemic control and insulin resistance in patients with type 2 diabetes.	Folic Acid	13-23	insulin	Homo sapiens	108-115
21725561-3	2011	Here we show that non functionalized MSNs, synthesized using a PEG surfactant-based interfacial synthesis procedure, do not enter cells, while a highly specific, receptor mediated, cellular internalization of folic acid (FOL) grafted MSNs (MSN-FOL), occurs exclusively in folate receptor (FR) expressing cells.	Folic Acid	209-219	moesin	Homo sapiens	37-40
21674649-2	2011	The metabolism of folic acid and vitamin B12 intersect during the transfer of the methyl group from 5-methyltetrahydrofolate to homocysteine catalyzed by B12-dependent methioine synthase.	Folic Acid	18-28	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	154-157
21674649-5	2011	Exposure to extra folic acid through fortification may be detrimental to those with vitamin B12 deficiency.	Folic Acid	18-28	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	92-95
21674649-6	2011	Among participants of National Health And Nutrition Examination Survey with low vitamin B12 status, high serum folate (&gt;59 nmol/L) was associated with higher prevalence of anemia and cognitive impairment when compared with normal serum folate.	Folic Acid	111-117	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	88-91
21674649-7	2011	We also observed an increase in the plasma concentrations of total homocysteine and methylmalonic acid (MMA), two functional indicators of vitamin B12 status, with increase in plasma folate under low vitamin B12 status.	Folic Acid	183-189	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	208-211
21674649-8	2011	These data strongly imply that high plasma folate is associated with the exacerbation of both the biochemical and clinical status of vitamin B12 deficiency.	Folic Acid	43-49	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	141-144
21765609-0	2011	Relationship between dietary folate intake and plasma monocyte chemoattractant protein-1 and interleukin-8 in heart failure patients.	Folic Acid	29-35	C-X-C motif chemokine ligand 8	Homo sapiens	93-106
21765609-5	2011	Plasma C-reactive protein levels significantly correlated with dietary intakes of vitamin C (r = -0.30, p&lt;0.005), beta-carotene (r = -0.23, p&lt;0.05), and folate (r = -0.31, p&lt;0.005).	Folic Acid	159-165	C-reactive protein	Homo sapiens	7-25
21765609-8	2011	Dietary folate intake was found as a primary influencing factor on plasma levels of monocyte chemoattractant protein-1 (p&lt;0.005, R(2) = 0.20) and interleukin-8 (p&lt;0.001, R(2) = 0.32) through a stepwise multiple linear regression analysis.	Folic Acid	8-14	C-X-C motif chemokine ligand 8	Homo sapiens	149-162
21765609-9	2011	Dietary folate intake was significantly associated with plasma levels of monocyte chemoattractant protein-1 and interleukin-8 which indicates dietary folate may have a potentially beneficial role in the prevention and treatment of heart failure.	Folic Acid	8-14	C-X-C motif chemokine ligand 8	Homo sapiens	112-125
21765609-9	2011	Dietary folate intake was significantly associated with plasma levels of monocyte chemoattractant protein-1 and interleukin-8 which indicates dietary folate may have a potentially beneficial role in the prevention and treatment of heart failure.	Folic Acid	150-156	C-X-C motif chemokine ligand 8	Homo sapiens	112-125
21490592-1	2011	The enzyme methylenetetrahydrofolate reductase (MTHFR) is a part of the homocysteine and folate metabolic pathways, affecting the methylations of DNA, RNA, and proteins.	Folic Acid	30-36	methylenetetrahydrofolate reductase	Mus musculus	48-53
21517845-0	2011	Folate is related to phosphorylated neurofilament-H and P-tau (Ser396) in rat brain.	Folic Acid	0-6	microtubule-associated protein tau	Rattus norvegicus	56-61
21752326-0	2011	[Effects of maternal deficiency of folic acid during pregnancy on pulmonary development and SP-A expression in newborn rats].	Folic Acid	35-45	surfactant protein A1	Rattus norvegicus	92-96
21752326-11	2011	CONCLUSIONS: Maternal deficiency of folic acid during pregnancy can decrease the expression of SP-A in lung tissues of newborn rats, which might lead to the disorder of lung development maturation.	Folic Acid	36-46	surfactant protein A1	Rattus norvegicus	95-99
21389855-5	2011	RESULTS: We found a significant increase in basal (P &lt; 0.02) and adenosine-induced (P &lt; 0.05) coronary blood flow in patients who received folic acid/vitamin B12 for 24 months, compared with placebo or vitamin B6 alone.	Folic Acid	145-155	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	164-167
21517845-10	2011	Plasma folate correlated to brain tissue PP2A activity (r=0.28), pNF-H (r=-0.30), and P-tau (Ser396) staining (r=-0.57) all p&lt;0.05.	Folic Acid	7-13	microtubule-associated protein tau	Rattus norvegicus	86-91
21593720-11	2011	Determinants of ratings of success on PGA were adequate analgesia and SPI &lt;= 4.	Folic Acid	38-41	chromogranin A	Homo sapiens	70-73
21634075-19	2004	PSMA may play an important role in the progression of prostate cancer and glutamatergic neurotransmission, as well as in the absorption of folate (26).	Folic Acid	139-145	folate hydrolase 1	Homo sapiens	0-4
21554707-1	2011	BACKGROUND: The enzyme dihydropteroate synthase (DHPS) participates in the de novo synthesis of folate cofactors by catalyzing the formation of 7,8-dihydropteroate from condensation of p-aminobenzoic acid with 6-hydroxymethyl-7,8-dihydropteroate pyrophosphate.	Folic Acid	96-102	deoxyhypusine synthase	Homo sapiens	49-53
21554707-2	2011	DHPS is absent from humans, who acquire folates from diet, and has been validated as an antimicrobial therapeutic target by chemical and genetic means.	Folic Acid	40-47	deoxyhypusine synthase	Homo sapiens	0-4
21210071-0	2011	GNMT expression increases hepatic folate contents and folate-dependent methionine synthase-mediated homocysteine remethylation.	Folic Acid	34-40	glycine N-methyltransferase	Homo sapiens	0-4
21205217-0	2011	Genistein and folic acid prevent oxidative injury induced by beta-amyloid peptide.	Folic Acid	14-24	amyloid beta precursor protein	Homo sapiens	61-81
21349824-5	2011	Folic acid increased the invasion of EVT cells in this explant model by between 83% and 19% (P = 0.005), and this was associated with increased MKI67 positivity and decreased active caspase 3 positivity; this effect was concentration dependent and showed a biphasic response.	Folic Acid	0-10	marker of proliferation Ki-67	Homo sapiens	144-149
21349824-5	2011	Folic acid increased the invasion of EVT cells in this explant model by between 83% and 19% (P = 0.005), and this was associated with increased MKI67 positivity and decreased active caspase 3 positivity; this effect was concentration dependent and showed a biphasic response.	Folic Acid	0-10	caspase 3	Homo sapiens	182-191
21210071-3	2011	GNMT is commonly diminished in human hepatoma; yet its role in cellular folate metabolism, in tumorigenesis and antifolate therapies, is not understood completely.	Folic Acid	72-78	glycine N-methyltransferase	Homo sapiens	0-4
21210071-5	2011	GNMT-diminished hepatoma cell lines transfected with GNMT were cultured under folate abundance or restriction.	Folic Acid	78-84	glycine N-methyltransferase	Homo sapiens	0-4
21494626-3	2011	Therefore we experimentally modulated galectin-3 in folic acid (FA)-induced acute kidney injury utilising modified citrus pectin (MCP), a derivative of pectin which can bind to the galectin-3 carbohydrate recognition domain thereby predominantly antagonising functions linked to this role.	Folic Acid	52-62	lectin, galactose binding, soluble 3	Mus musculus	38-48
21210071-8	2011	In the cell model, GNMT expression increased folate concentration, induced folate-dependent homocysteine remethylation, and reduced antifolate methotrexate cytotoxicity.	Folic Acid	45-51	glycine N-methyltransferase	Homo sapiens	19-23
21210071-8	2011	In the cell model, GNMT expression increased folate concentration, induced folate-dependent homocysteine remethylation, and reduced antifolate methotrexate cytotoxicity.	Folic Acid	75-81	glycine N-methyltransferase	Homo sapiens	19-23
21210071-10	2011	Liver folate levels correlated well with GNMT expressions (r = 0.53, P = 0.002); and methionine synthase expression was reduced significantly in GNMT(ko), demonstrating impaired methylfolate-dependent metabolism by GNMT deletion.	Folic Acid	6-12	glycine N-methyltransferase	Homo sapiens	41-45
21210071-11	2011	In conclusion, we demonstrated novel findings that restoring GNMT assists methylfolate-dependent reactions and ameliorates the consequences of folate depletion.	Folic Acid	80-86	glycine N-methyltransferase	Homo sapiens	61-65
21210071-12	2011	GNMT expression in vivo improves folate retention and bioavailability in the liver.	Folic Acid	33-39	glycine N-methyltransferase	Homo sapiens	0-4
21210071-13	2011	Studies on how GNMT expression impacts the distribution of different folate cofactors and the regulation of specific folate dependent reactions are underway.	Folic Acid	69-75	glycine N-methyltransferase	Homo sapiens	15-19
21210071-13	2011	Studies on how GNMT expression impacts the distribution of different folate cofactors and the regulation of specific folate dependent reactions are underway.	Folic Acid	117-123	glycine N-methyltransferase	Homo sapiens	15-19
20864946-3	2011	We tested whether in MS+, folic acid (FA) treatment could normalize NO synthase (NOS)-dependence of vascular tone in the retina and kidney.	Folic Acid	26-36	nitric oxide synthase 2	Homo sapiens	68-79
21369671-0	2011	Supplementation with apple juice can compensate for folate deficiency in a mouse model deficient in methylene tetrahydrofolate reductase activity.	Folic Acid	52-58	methylenetetrahydrofolate reductase	Mus musculus	100-136
21781437-4	2011	ABCB1 gene codes for a drug-transport pump in charge to protect the cell by extruding a variety of harmful exogens, but with a reduced activity in a folate-restricted condition.	Folic Acid	149-155	ATP binding cassette subfamily B member 1	Homo sapiens	0-5
21185364-0	2011	Interaction of folate-conjugated human serum albumin (HSA) nanoparticles with tumour cells.	Folic Acid	15-21	albumin	Homo sapiens	39-52
21185364-2	2011	Here, we investigated cellular uptake of folic acid-conjugated human serum albumin nanoparticles (HSA NPs).	Folic Acid	41-51	albumin	Homo sapiens	69-82
21183151-7	2011	CONCLUSION: Mothers carrying the MDR1 3435T allele, using medication without folic acid, are at nearly 3-fold increased risk for CHD in the offspring.	Folic Acid	77-87	ATP binding cassette subfamily B member 1	Homo sapiens	33-37
21186059-5	2011	Compared to non-specific delivery, the folate-targeted delivery of BCL-2 siRNA resulted in more significant gene suppression at both the BCL-2 mRNA and protein expression levels, inducing cancer cell apoptosis and improving the therapeutic efficacy of the co-administered DOX.	Folic Acid	39-45	BCL2 apoptosis regulator	Homo sapiens	67-72
21186059-5	2011	Compared to non-specific delivery, the folate-targeted delivery of BCL-2 siRNA resulted in more significant gene suppression at both the BCL-2 mRNA and protein expression levels, inducing cancer cell apoptosis and improving the therapeutic efficacy of the co-administered DOX.	Folic Acid	39-45	BCL2 apoptosis regulator	Homo sapiens	137-142
21179048-3	2011	We examined whether folate nutrition modifies the relationship between serum CRP concentration and gestational age at delivery.	Folic Acid	20-26	C-reactive protein	Homo sapiens	77-80
21179048-8	2011	Serum folate concentration was negatively correlated (P &lt; 0.01) with serum CRP concentration, and total dietary folate intake was positively correlated (P &lt; 0.001) with serum folate concentration.	Folic Acid	6-12	C-reactive protein	Homo sapiens	78-81
21179048-9	2011	Multiple regression analysis after adjustment for covariates revealed that maternal CRP concentrations were negatively associated with gestational age at delivery; these negative associations existed only when folate intake during pregnancy was below the Korean estimated average requirements (520 mug dietary folate equivalent per day), and serum folate concentrations were above the normal (6 ng/ml).	Folic Acid	210-216	C-reactive protein	Homo sapiens	84-87
21179048-9	2011	Multiple regression analysis after adjustment for covariates revealed that maternal CRP concentrations were negatively associated with gestational age at delivery; these negative associations existed only when folate intake during pregnancy was below the Korean estimated average requirements (520 mug dietary folate equivalent per day), and serum folate concentrations were above the normal (6 ng/ml).	Folic Acid	310-316	C-reactive protein	Homo sapiens	84-87
21179048-9	2011	Multiple regression analysis after adjustment for covariates revealed that maternal CRP concentrations were negatively associated with gestational age at delivery; these negative associations existed only when folate intake during pregnancy was below the Korean estimated average requirements (520 mug dietary folate equivalent per day), and serum folate concentrations were above the normal (6 ng/ml).	Folic Acid	310-316	C-reactive protein	Homo sapiens	84-87
21179048-10	2011	CONCLUSIONS: We found that adequate maternal folate intake during pregnancy may have a beneficial role against shorter gestational age at delivery, which is associated with higher serum CRP concentrations in pregnant women.	Folic Acid	45-51	C-reactive protein	Homo sapiens	186-189
21421131-0	2011	Interaction of folic acid and some matrix metalloproteinase (MMP) inhibitor folate-gamma-hydroxamate derivatives with Zn(II) and human serum albumin.	Folic Acid	15-25	albumin	Homo sapiens	135-148
21421131-0	2011	Interaction of folic acid and some matrix metalloproteinase (MMP) inhibitor folate-gamma-hydroxamate derivatives with Zn(II) and human serum albumin.	Folic Acid	76-82	albumin	Homo sapiens	135-148
21421131-1	2011	Human serum albumin binding of folic acid and its gamma-hydroxamate/carboxylate derivatives was studied by ultrafiltration and spectrofluorimetry, and it was found that the ligands exhibit a moderate binding (K(D) ~2-50 muM), and the folate-gamma-phenylalanine represents the highest conditional binding constant towards albumin.	Folic Acid	31-41	albumin	Homo sapiens	6-19
21421131-1	2011	Human serum albumin binding of folic acid and its gamma-hydroxamate/carboxylate derivatives was studied by ultrafiltration and spectrofluorimetry, and it was found that the ligands exhibit a moderate binding (K(D) ~2-50 muM), and the folate-gamma-phenylalanine represents the highest conditional binding constant towards albumin.	Folic Acid	31-41	latexin	Homo sapiens	220-223
21270363-9	2011	People with a SNPs in MTHFD1 (a gene of folate metabolism that controls the use of folate as a methyl donor) are more likely to develop organ dysfunction when deprived of choline; their dietary requirement is increased because of increased need for choline as a methyl donor.	Folic Acid	40-46	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	22-28
21270363-9	2011	People with a SNPs in MTHFD1 (a gene of folate metabolism that controls the use of folate as a methyl donor) are more likely to develop organ dysfunction when deprived of choline; their dietary requirement is increased because of increased need for choline as a methyl donor.	Folic Acid	83-89	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	22-28
21537707-1	2011	OBJECTIVE: To investigate the MTHFD1 G1958A polymorphism involved in the folate metabolism as a risk for head and neck cancer, and to find the association of the polymorphism with the risk factors and clinical and histopathological characteristics.	Folic Acid	73-79	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	30-36
21765920-7	2011	Interestingly, miR-22 and miR-125 are significantly up-regulated in cells grown under low-folate conditions.	Folic Acid	90-96	microRNA 22	Homo sapiens	15-21
20641246-20	2004	PSMA may play an important role in the progression of prostate cancer and glutamatergic neurotransmission, as well as in the absorption of folate (4).	Folic Acid	139-145	folate hydrolase 1	Homo sapiens	0-4
21779486-1	2011	FDH (10-formyltetrahydrofolate dehydrogenase, the product of the ALDH1L1 gene), a major folate-metabolizing enzyme in the cytosol, is involved in the regulation of cellular proliferation.	Folic Acid	24-30	aldehyde dehydrogenase 1 family member L1	Homo sapiens	0-3
21779486-1	2011	FDH (10-formyltetrahydrofolate dehydrogenase, the product of the ALDH1L1 gene), a major folate-metabolizing enzyme in the cytosol, is involved in the regulation of cellular proliferation.	Folic Acid	24-30	aldehyde dehydrogenase 1 family member L1	Homo sapiens	65-72
21052817-0	2011	Common polymorphisms in methylenetetrahydrofolate reductase gene are associated with risks of cervical intraepithelial neoplasia and cervical cancer in women with low serum folate and vitamin B12.	Folic Acid	43-49	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	192-195
21297321-7	2011	Atopic asthmatics with a total serum IgE &lt;=200 IU/mL had significantly higher levels of serum folate than those with a total serum IgE &gt;200 IU/mL.	Folic Acid	97-103	immunoglobulin heavy constant epsilon	Homo sapiens	37-40
21297321-8	2011	Regression analysis showed that higher folate levels independently predicted lower total serum IgE levels.	Folic Acid	39-45	immunoglobulin heavy constant epsilon	Homo sapiens	95-98
20334533-1	2011	OBJECTIVE: Our aim was to evaluate the possible association between recurrent spontaneous abortions (RSA) and the c.1958 G&gt;A SNP in the MTHFD1 gene encoding a trifunctional enzyme involved in DNA synthesis and folate metabolism.	Folic Acid	213-219	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	139-145
21916701-2	2011	We investigated the association of intake of folate, vitamins B(2), B(6), B(12), and methionine with promoter methylation of E-cadherin, p16, and RAR-beta(2) genes in archived tumor tissues from incident, primary breast cancer cases in a population-based case-control study.	Folic Acid	45-51	cadherin 1	Homo sapiens	125-135
21916701-2	2011	We investigated the association of intake of folate, vitamins B(2), B(6), B(12), and methionine with promoter methylation of E-cadherin, p16, and RAR-beta(2) genes in archived tumor tissues from incident, primary breast cancer cases in a population-based case-control study.	Folic Acid	45-51	cyclin dependent kinase inhibitor 2A	Homo sapiens	137-140
21916701-2	2011	We investigated the association of intake of folate, vitamins B(2), B(6), B(12), and methionine with promoter methylation of E-cadherin, p16, and RAR-beta(2) genes in archived tumor tissues from incident, primary breast cancer cases in a population-based case-control study.	Folic Acid	45-51	retinoic acid receptor beta	Homo sapiens	146-154
20711807-7	2010	The plasma levels of folate and vitamin B(12) were inversely related to the hypermethylation status of ERalpha, after controlling for covariates.	Folic Acid	21-27	estrogen receptor 1	Homo sapiens	103-110
20729910-9	2010	Dephosphorylation of cofilin and inhibition of motility in response to FDH can also be prevented by the increased folate in media.	Folic Acid	114-120	aldehyde dehydrogenase 1 family member L1	Homo sapiens	71-74
21589310-1	2010	In the title one-dimensional coordination polymer, [Co(C(2)H(3)O(2))(2)(C(26)H(18)N(4))](n), the Co(II) atom (site symmetry 2) is coordinated by two O,O"-bidentate acetate ions and two 4,4"-bis-(benzimidazol-1-yl)biphenyl ligands in a distorted cis-CoN(2)O(4) octa-hedral geometry.	Folic Acid	81-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-103
20890936-1	2010	BACKGROUND: Polymorphisms in genes that are involved in folic acid metabolism may be important maternal risk factors for the birth of a child with nonsyndromic cleft lip and/or palate (NSCL/P).	Folic Acid	56-66	nescient helix-loop-helix 1	Homo sapiens	185-189
20890936-2	2010	The aim of this study was to determine the involvement of polymorphic variants in four genes (MTHFR, MTHFD1, MTR, and SLC19A1) that encode proteins related to folic acid metabolism in the women with susceptibility for having a child with NSCL/P.	Folic Acid	159-169	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	101-107
20890936-2	2010	The aim of this study was to determine the involvement of polymorphic variants in four genes (MTHFR, MTHFD1, MTR, and SLC19A1) that encode proteins related to folic acid metabolism in the women with susceptibility for having a child with NSCL/P.	Folic Acid	159-169	nescient helix-loop-helix 1	Homo sapiens	238-242
20890936-8	2010	CONCLUSION: The findings of the present study suggested that genetic variants of folic acid metabolic genes may modulate maternal susceptibility for having an offspring with NSCL/P.	Folic Acid	81-91	nescient helix-loop-helix 1	Homo sapiens	174-178
20659431-7	2010	Actin remodeling induced by 100 muM Hcy was prevented by the antioxidants folate (5 muM) or trolox (80 muM).	Folic Acid	74-80	latexin	Homo sapiens	32-35
20659431-7	2010	Actin remodeling induced by 100 muM Hcy was prevented by the antioxidants folate (5 muM) or trolox (80 muM).	Folic Acid	74-80	latexin	Homo sapiens	84-87
20659431-7	2010	Actin remodeling induced by 100 muM Hcy was prevented by the antioxidants folate (5 muM) or trolox (80 muM).	Folic Acid	74-80	latexin	Homo sapiens	84-87
22419938-1	2010	INTRODUCTION: Susceptibility to head and neck squamous cell carcinoma may be modified by functional polymorphisms in genes involved in the folate pathway, such as cystathionine beta-synthase (CBS).	Folic Acid	139-145	cystathionine beta-synthase	Homo sapiens	163-190
22419938-1	2010	INTRODUCTION: Susceptibility to head and neck squamous cell carcinoma may be modified by functional polymorphisms in genes involved in the folate pathway, such as cystathionine beta-synthase (CBS).	Folic Acid	139-145	cystathionine beta-synthase	Homo sapiens	192-195
21244768-5	2010	CRP and homocysteine levels were higher in patients with psoriasis than in controls (5.9 +- 7.1 vs 3.1 +- 2.4 mg/L, p=0.0003 and 16.3 +- 12.8 vs 10.4 +- 4.6 umol/L, p=0.0001; mean +- SD) whereas folic acid was lower in psoriatic patients compared to controls (4.3 +- 7.2 vs 12.6 +- 7.9 p=0.006).	Folic Acid	195-205	C-reactive protein	Homo sapiens	0-3
20957218-0	2010	Preparation, characterization, and in vitro targeted delivery of folate-decorated paclitaxel-loaded bovine serum albumin nanoparticles.	Folic Acid	65-71	albumin	Homo sapiens	107-120
20957218-8	2010	The amount of folate conjugation was 9.22 mug/mg of bovine serum albumin.	Folic Acid	14-20	albumin	Homo sapiens	59-72
21070756-7	2011	CONCLUSION: Our findings provide support for the synergistic effects of polymorphisms in the folate metabolic pathway genes in PD susceptibility; the increased PD risk would be more significant in carriers with the polymorphisms of MTHFR, MTR, and MTRR genes.	Folic Acid	93-99	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	248-252
21788695-0	2011	Study of KAP with regard to taking folic acid supplements and factors affecting the recommendation and prescription of those supplements among obstetricians and specialists in women"s health in six provinces of Northern China, 2009.	Folic Acid	35-45	napsin A aspartic peptidase	Homo sapiens	9-12
21499429-0	2011	Preparation, characterization and targeting of micronized 10-hydroxycamptothecin-loaded folate-conjugated human serum albumin nanoparticles to cancer cells.	Folic Acid	88-94	albumin	Homo sapiens	112-125
21499429-2	2011	METHODS: We first used a supercritical antisolvent process to prepare micronized HCPT (nHCPT), and then folate-conjugated human serum albumin (HSA) nHCPT-loaded NPs (FA-HSA-nHCPT-NPs) were prepared using a NP-coated method combined with a desolvation technique.	Folic Acid	104-110	albumin	Homo sapiens	128-141
21297321-6	2011	Among atopic asthmatics, serum folate levels were inversely correlated with total serum IgE levels (r=-0.483, p&lt;0.001), and the number of positive SPT reactions (r=-0.442, p&lt;0.001).	Folic Acid	31-37	immunoglobulin heavy constant epsilon	Homo sapiens	88-91
21335214-4	2011	This approach is allowed by the use of recombinant human erythropoietin in association with erythropoiesis-inducing factors such as iron and folic acid.	Folic Acid	141-151	erythropoietin	Homo sapiens	57-71
20411324-1	2010	Methionine synthase reductase (MTRR) is one of the important enzymes involved in the folate metabolic pathway and its functional genetic polymorphisms may be associated with breast cancer risk.	Folic Acid	85-91	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	0-29
20411324-1	2010	Methionine synthase reductase (MTRR) is one of the important enzymes involved in the folate metabolic pathway and its functional genetic polymorphisms may be associated with breast cancer risk.	Folic Acid	85-91	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	31-35
21149331-10	2010	Higher RBC folate levels were associated with higher levels of both ERalpha (P = 0.03) and SFRP1 methylation (P = 0.01).	Folic Acid	11-17	estrogen receptor 1	Homo sapiens	68-75
22432562-8	2010	Overexpression of p53 mRNA was observed in both cancerous cell lines, but it was differentially altered by folic acid administration in only SCC25 cells.	Folic Acid	107-117	tumor protein p53	Homo sapiens	18-21
22432562-9	2010	These findings suggest folic acid administration may significantly alter growth of oral cancers in vitro via p53-dependent and p53-independent pathways.	Folic Acid	23-33	tumor protein p53	Homo sapiens	109-112
22432562-9	2010	These findings suggest folic acid administration may significantly alter growth of oral cancers in vitro via p53-dependent and p53-independent pathways.	Folic Acid	23-33	tumor protein p53	Homo sapiens	127-130
20802128-3	2010	Folic acid (FA) decreases Hcy levels by remethylating the Hcy to methionine, by 5-methylene tetrahydrofolate reductase (5-MTHFR).	Folic Acid	0-10	methylenetetrahydrofolate reductase	Mus musculus	122-127
20624932-3	2010	Here, we report a novel function of glutamate carboxypeptidase II (GCPII) in Abeta degradation in brain, which is a peptidase involved in N-acetylaspartylglutamate cleavage, folate metabolism, and prostate tumorigenesis.	Folic Acid	174-180	folate hydrolase 1	Mus musculus	36-65
20624932-3	2010	Here, we report a novel function of glutamate carboxypeptidase II (GCPII) in Abeta degradation in brain, which is a peptidase involved in N-acetylaspartylglutamate cleavage, folate metabolism, and prostate tumorigenesis.	Folic Acid	174-180	folate hydrolase 1	Mus musculus	67-72
20827489-9	2010	Significant immunohistochemical differences could be detected between PGA with and without adenocarcinoma regarding ki67 and p53.	Folic Acid	70-73	tumor protein p53	Homo sapiens	125-128
20572035-7	2010	CONCLUSIONS: The loss of p16 in LN metastases contributed to adverse outcomes in adjuvantly treated patients with stage III colorectal cancer independent of pathologic tumor classification, age, LN ratio, performance status, or folic acid treatment.	Folic Acid	228-238	cyclin dependent kinase inhibitor 2A	Homo sapiens	25-28
20803414-0	2010	Dietary folic acid activates AMPK and improves insulin resistance and hepatic inflammation in dietary rodent models of the metabolic syndrome.	Folic Acid	8-18	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	29-33
20803414-7	2010	In vivo insulin sensitivity was improved, and in HF-FA rats folic acid increased activation of hepatic AMPK.	Folic Acid	60-70	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	103-107
20542893-10	2010	Patients with active or persistent disease with PGA had higher DEI.Tak compared with inactives [1.3 (1.9), 1 (1.3) vs 0.2 (0.6), respectively; P &lt; 0.001].	Folic Acid	48-51	cyclin dependent kinase 9	Homo sapiens	67-70
20542893-15	2010	Although the agreement between Kerr"s criteria and DEI.Tak seemed very good, using Kerr"s criteria instead of DEI.Tak increased the consistency with PGA, which could be explained by the influence of imaging data and acute-phase reactant levels on the physician"s decisions.	Folic Acid	149-152	cyclin dependent kinase 9	Homo sapiens	114-117
20544798-10	2010	In African Americans, folate derivative levels were associated with smoking, B(12), and polymorphisms in MTR, TYMS, methionine synthase reductase (MTRR), and reduced folate carrier1 (RFC1).	Folic Acid	22-28	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	116-145
20698054-7	2010	Dietary vitamin E was associated with decreased risk of ER and PGR positive breast cancer (IRR: 0.50; 95% CI: 0.25-0.98) and dietary folate was associated with increased risk of ER and PGR positive breast cancer (IRR: 1.27; 95% CI: 1.03-1.95).	Folic Acid	133-139	estrogen receptor 1	Homo sapiens	178-180
19879746-10	2010	Moreover, folic acid caused a reduction in PTEN (phosphatase and tensin homolog deleted on chromosome 10) expression, an increase in the phosphorylation of endothelial nitric oxide synthase (eNOS(Ser1177)) and Akt(Ser473), and an enhanced interaction of heat shock protein 90 (HSP90) with eNOS in both strains, with greater magnitude observed in +db/+db mice.	Folic Acid	10-20	phosphatase and tensin homolog	Mus musculus	43-47
19879746-10	2010	Moreover, folic acid caused a reduction in PTEN (phosphatase and tensin homolog deleted on chromosome 10) expression, an increase in the phosphorylation of endothelial nitric oxide synthase (eNOS(Ser1177)) and Akt(Ser473), and an enhanced interaction of heat shock protein 90 (HSP90) with eNOS in both strains, with greater magnitude observed in +db/+db mice.	Folic Acid	10-20	thymoma viral proto-oncogene 1	Mus musculus	210-213
21072292-3	2010	METHODS: The associations between serum concentrations of folate and vitamin B12 and HR-HPV infections were evaluated in 724 women who participated in a CC screening study in the southern state of Andhra Pradesh, India.	Folic Acid	58-64	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	77-80
21072292-8	2010	RESULTS: Women with higher concentrations of serum folate (&gt;6 ng/mL) and vitamin B12 (&gt;356 pg/mL) were at lower risk of being positive for HR-HPVs compared to those with serum folate &lt;=6 ng/mL and serum vitamin B12 &lt;= 356 pg/mL (odds ratio = 0.26; 95% confidence interval: 0.08-0.89; P = 0.03).	Folic Acid	51-57	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	220-223
21072292-8	2010	RESULTS: Women with higher concentrations of serum folate (&gt;6 ng/mL) and vitamin B12 (&gt;356 pg/mL) were at lower risk of being positive for HR-HPVs compared to those with serum folate &lt;=6 ng/mL and serum vitamin B12 &lt;= 356 pg/mL (odds ratio = 0.26; 95% confidence interval: 0.08-0.89; P = 0.03).	Folic Acid	182-188	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	84-87
20536259-9	2010	Furthermore, targeted delivery of cytochrome c to folate-receptor-positive cancer cells was achieved via conjugation of folic acid to the nanoparticle"s surface, whereas the nanoparticle"s theranostic properties were conferred via the coencapsulation of cytochrome c and a fluorescent dye.	Folic Acid	120-130	cytochrome c, somatic	Homo sapiens	34-46
20589880-0	2010	Neural tube defects induced by folate deficiency in mutant curly tail (Grhl3) embryos are associated with alteration in folate one-carbon metabolism but are unlikely to result from diminished methylation.	Folic Acid	31-37	grainyhead like transcription factor 3	Mus musculus	71-76
20589880-8	2010	CONCLUSIONS: Curly tail fibroblasts and embryos, in which Grhl3 expression is reduced, display alterations in one-carbon metabolism, particularly in the response to folate deficiency, compared to genetically matched congenic controls in which Grhl3 is unaffected.	Folic Acid	165-171	grainyhead like transcription factor 3	Mus musculus	58-63
20544798-10	2010	In African Americans, folate derivative levels were associated with smoking, B(12), and polymorphisms in MTR, TYMS, methionine synthase reductase (MTRR), and reduced folate carrier1 (RFC1).	Folic Acid	22-28	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	147-151
20498374-1	2010	Cytosolic 10-formyltetrahydrofolate dehydrogenase (FDH, ALDH1L1) is an abundant enzyme of folate metabolism.	Folic Acid	29-35	aldehyde dehydrogenase 1 family member L1	Homo sapiens	51-54
20498374-1	2010	Cytosolic 10-formyltetrahydrofolate dehydrogenase (FDH, ALDH1L1) is an abundant enzyme of folate metabolism.	Folic Acid	29-35	aldehyde dehydrogenase 1 family member L1	Homo sapiens	56-63
20821592-4	2010	Sulfonamides inhibit the growth of sensitive microorganisms by competitive binding to the dihydropteroate-synthase (DHPS) enzyme of folic acid production.	Folic Acid	132-142	deoxyhypusine synthase	Homo sapiens	90-114
20662139-11	2004	PSMA may play an important role in the progression of prostate cancer and glutamatergic neurotransmission, as well as in the absorption of folate (9).	Folic Acid	139-145	folate hydrolase 1	Homo sapiens	0-4
20851295-6	2010	RESULTS: In the treatment arm, oral supplementation with folate and vitamin B12 significantly improved total cholesterol, serum folate, serum vitamin B12, homocysteine, and insulin resistance.	Folic Acid	57-63	insulin	Homo sapiens	173-180
20205967-0	2010	Ageing, chronic alcohol consumption and folate are determinants of genomic DNA methylation, p16 promoter methylation and the expression of p16 in the mouse colon.	Folic Acid	40-46	cytochrome P450, family 2, subfamily b, polypeptide 10	Mus musculus	92-95
20205967-0	2010	Ageing, chronic alcohol consumption and folate are determinants of genomic DNA methylation, p16 promoter methylation and the expression of p16 in the mouse colon.	Folic Acid	40-46	cytochrome P450, family 2, subfamily b, polypeptide 10	Mus musculus	139-142
20205967-9	2010	In young mice the combination of alcohol and reduced dietary folate led to significantly decreased p16 expression compared with the control group (P &lt; 0.02).	Folic Acid	61-67	cytochrome P450, family 2, subfamily b, polypeptide 10	Mus musculus	99-102
20140757-4	2010	Accordingly, HSS associated with hyperhomocysteinemia was diagnosed, and the clinical and radiological improvement was achieved after treatment with prednisolone, warfarin, and folic acid.	Folic Acid	177-187	pantothenate kinase 2	Homo sapiens	13-16
20821592-4	2010	Sulfonamides inhibit the growth of sensitive microorganisms by competitive binding to the dihydropteroate-synthase (DHPS) enzyme of folic acid production.	Folic Acid	132-142	deoxyhypusine synthase	Homo sapiens	116-120
20374669-3	2010	Inherited polymorphisms in key folate metabolic pathway genes, MTHFR and MTHFD, may influence the efficiency of folate metabolism and plasma level of homocysteine.	Folic Acid	31-37	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	73-78
21716795-10	2010	Plasma folate correlated positively with CD4 cell count (r = 0.304, P&lt;0.05) and inversely with the viral load (r = -0.566; P&lt;0.05).	Folic Acid	7-13	CD4 molecule	Homo sapiens	41-44
20374669-3	2010	Inherited polymorphisms in key folate metabolic pathway genes, MTHFR and MTHFD, may influence the efficiency of folate metabolism and plasma level of homocysteine.	Folic Acid	112-118	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	73-78
20053979-10	2010	CONCLUSIONS: FRalpha and PCFT are expressed in retinal Muller cells and colocalize in the endosomal compartment, suggesting that the two proteins may work coordinately to mediate folate uptake.	Folic Acid	179-185	rabaptin, RAB GTPase binding effector protein 2	Mus musculus	13-20
20386493-4	2010	RESULTS: RBC folate concentrations were significantly associated with MTHFR 677C&gt;T (P=0.002), MTRR 66A&gt;G (P&lt;0.0001), MTHFD1 1958G&gt;A (P=0.001) and SHMT 1420C&gt;T (P=0.012), whereas no association of these polymorphisms with disease activity was observed.	Folic Acid	13-19	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	97-101
20386493-4	2010	RESULTS: RBC folate concentrations were significantly associated with MTHFR 677C&gt;T (P=0.002), MTRR 66A&gt;G (P&lt;0.0001), MTHFD1 1958G&gt;A (P=0.001) and SHMT 1420C&gt;T (P=0.012), whereas no association of these polymorphisms with disease activity was observed.	Folic Acid	13-19	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	126-132
20188806-3	2010	The results showed that folate deficiency significantly aggravated the NaAsO(2)-induced apoptotic progression [evidenced by phosphatidylserine externalization, cleavage of caspase-3 and poly (ADP-ribose) polymerase (PARP), collapse of mitochondrial potential, and release of cytochrome c from the mitochondria] and decrease of cell viability.	Folic Acid	24-30	caspase 3	Homo sapiens	172-214
20188806-3	2010	The results showed that folate deficiency significantly aggravated the NaAsO(2)-induced apoptotic progression [evidenced by phosphatidylserine externalization, cleavage of caspase-3 and poly (ADP-ribose) polymerase (PARP), collapse of mitochondrial potential, and release of cytochrome c from the mitochondria] and decrease of cell viability.	Folic Acid	24-30	poly(ADP-ribose) polymerase 1	Homo sapiens	216-220
20188806-3	2010	The results showed that folate deficiency significantly aggravated the NaAsO(2)-induced apoptotic progression [evidenced by phosphatidylserine externalization, cleavage of caspase-3 and poly (ADP-ribose) polymerase (PARP), collapse of mitochondrial potential, and release of cytochrome c from the mitochondria] and decrease of cell viability.	Folic Acid	24-30	cytochrome c, somatic	Homo sapiens	275-287
20441590-2	2010	The FOLT-1 protein has been shown to transport folate and to be involved in uptake of exogenous folate by worms.	Folic Acid	47-53	Folate transporter 1	Caenorhabditis elegans	4-10
20441590-2	2010	The FOLT-1 protein has been shown to transport folate and to be involved in uptake of exogenous folate by worms.	Folic Acid	96-102	Folate transporter 1	Caenorhabditis elegans	4-10
20375932-1	2010	BACKGROUND: Laboratory evidence is presented of significant associations between reduced maternal serum folate and vitamin B12 levels and neural tube birth defects (NTD) compared to referents.	Folic Acid	104-110	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	123-126
20412928-10	2010	The relative mRNA abundance of 5,10-methylene-tetrahydrofolate reductase and methylmalonyl-CoA mutase were increased by the combined injections of folic acid and vitamin B(12), whereas those of methionine synthase and methionine synthase reductase were not affected by treatments.	Folic Acid	147-157	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Bos taurus	218-247
19713034-3	2010	NSE is one of the enolase families that convert 2-phospho-d-glycerate (PGA) to phosphoenolpyruvate (PEP) in the glycolysis pathway.	Folic Acid	71-74	enolase 2	Homo sapiens	0-3
19968891-10	2010	Low serum vitamin B12 was significantly associated with female sex, high coffee intake, low folate status, and the TT genotype of the MTHFR-C677T polymorphism.	Folic Acid	92-98	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	18-21
19606374-6	2010	Because adiponectin related to RCF we examined the effect of folate supplementation on adiponectin levels in obese children in a previously conducted randomized folate intervention trial.	Folic Acid	61-67	adiponectin, C1Q and collagen domain containing	Homo sapiens	87-98
19606374-12	2010	CONCLUSIONS: Obese children have lower adiponectin, which relates to decreased smooth muscle function and lower folate status.	Folic Acid	112-118	adiponectin, C1Q and collagen domain containing	Homo sapiens	39-50
20217437-2	2010	The aim of this study was to test the association of folate metabolism-related genes, cystathionine beta-synthase gene (CbetaS) and 5, 10-methylenetetrahydrofolate dehydrogenase gene (MTHFD1), with sporadic AD.	Folic Acid	53-59	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	184-190
19636555-10	2010	CONCLUSIONS: The expression level of FPGS, GGH and ABCC1 in CRC tissues could predict the reduced folate level after LV administration, and these factors may determine the efficacy of LV treatment.	Folic Acid	98-104	ATP binding cassette subfamily C member 1	Homo sapiens	51-56
20025073-1	2010	Recent studies have suggested an association between dietary folate, and related B-vitamins, and risk for cancer, potentially mediated by the p53 tumor suppressor gene.	Folic Acid	61-67	tumor protein p53	Homo sapiens	142-145
20001219-0	2010	In vitro evaluation of a Folate-bovine serum albumin-doxorubicin conjugate.	Folic Acid	25-31	albumin	Homo sapiens	39-52
20025073-2	2010	The aim of this study was to explore the effect of dietary folate and vitamin B(6) intake on p53 in the molecular pathogenesis of esophageal adenocarcinoma (EADC).	Folic Acid	59-65	tumor protein p53	Homo sapiens	93-96
21125813-0	2010	Inhibition by folic acid of tumor necrosis factor alpha and apoptosis following normothermic ischemia-reperfusion.	Folic Acid	14-24	tumor necrosis factor	Rattus norvegicus	28-55
19824061-8	2010	Notably, folate deficiency caused a similar-sized, statistically significant increase in the frequency of cranial NTDs among both curly tail (Grhl3 mutant) embryos and background-matched embryos that are wild type for Grhl3.	Folic Acid	9-15	grainyhead like transcription factor 3	Mus musculus	142-147
19824061-8	2010	Notably, folate deficiency caused a similar-sized, statistically significant increase in the frequency of cranial NTDs among both curly tail (Grhl3 mutant) embryos and background-matched embryos that are wild type for Grhl3.	Folic Acid	9-15	grainyhead like transcription factor 3	Mus musculus	218-223
19932120-8	2010	An inverse correlation of folate levels with Nat2 enzyme activity was found.	Folic Acid	26-32	N-acetyltransferase 2 (arylamine N-acetyltransferase)	Mus musculus	45-49
19932120-9	2010	SIGNIFICANCE: Since increasing NAT1 activity decreases folate in at least one tissue, the detrimental effect of expression of human NAT1 in combination with endogenous mouse Nat2 may be a consequence of increased catabolism of folate.	Folic Acid	55-61	N-acetyltransferase 2 (arylamine N-acetyltransferase)	Mus musculus	174-178
19932120-9	2010	SIGNIFICANCE: Since increasing NAT1 activity decreases folate in at least one tissue, the detrimental effect of expression of human NAT1 in combination with endogenous mouse Nat2 may be a consequence of increased catabolism of folate.	Folic Acid	227-233	N-acetyltransferase 2 (arylamine N-acetyltransferase)	Mus musculus	174-178
19933275-3	2010	Recently, we have shown that one of the enzymes of folate metabolism, 10-formyltetrahydrofolate dehydrogenase (FDH), requires a 4-PP prosthetic group for catalysis.	Folic Acid	51-57	aldehyde dehydrogenase 1 family member L1	Homo sapiens	70-109
19933275-3	2010	Recently, we have shown that one of the enzymes of folate metabolism, 10-formyltetrahydrofolate dehydrogenase (FDH), requires a 4-PP prosthetic group for catalysis.	Folic Acid	51-57	aldehyde dehydrogenase 1 family member L1	Homo sapiens	111-114
21088384-5	2010	RESULTS: After exposure to a high concentration of folic acid (20 mumol/l), enhanced cancer cell growth and concomitant increased methylation of the ESR1 (3.6-fold), p16(INK)4(a) and p15(INK)4(b) promoters was observed.	Folic Acid	51-61	estrogen receptor 1	Homo sapiens	149-153
21088384-5	2010	RESULTS: After exposure to a high concentration of folic acid (20 mumol/l), enhanced cancer cell growth and concomitant increased methylation of the ESR1 (3.6-fold), p16(INK)4(a) and p15(INK)4(b) promoters was observed.	Folic Acid	51-61	cyclin dependent kinase inhibitor 2A	Homo sapiens	166-178
21088384-5	2010	RESULTS: After exposure to a high concentration of folic acid (20 mumol/l), enhanced cancer cell growth and concomitant increased methylation of the ESR1 (3.6-fold), p16(INK)4(a) and p15(INK)4(b) promoters was observed.	Folic Acid	51-61	cyclin dependent kinase inhibitor 2B	Homo sapiens	183-192
20026257-0	2010	Characterisation of CpG methylation in the upstream control region of mouse Nat2: evidence for a gene-environment interaction in a polymorphic gene implicated in folate metabolism.	Folic Acid	162-168	N-acetyltransferase 2 (arylamine N-acetyltransferase)	Mus musculus	76-80
20026257-2	2010	Both human NAT1 and its murine equivalent NAT2 have previously been shown to play roles in the catabolism of folate, which is required for the synthesis of S-adenosylmethionine, the methyl donor for cellular methylation reactions.	Folic Acid	109-115	N-acetyltransferase 2 (arylamine N-acetyltransferase)	Mus musculus	42-46
20026257-6	2010	Functional deletion of the Nat2 gene gave rise to a significant increase in Nat2 methylation, extending our previous observations that folate catabolism is decreased in Nat2 null mice.	Folic Acid	135-141	N-acetyltransferase 2 (arylamine N-acetyltransferase)	Mus musculus	27-31
20026257-6	2010	Functional deletion of the Nat2 gene gave rise to a significant increase in Nat2 methylation, extending our previous observations that folate catabolism is decreased in Nat2 null mice.	Folic Acid	135-141	N-acetyltransferase 2 (arylamine N-acetyltransferase)	Mus musculus	76-80
20026257-6	2010	Functional deletion of the Nat2 gene gave rise to a significant increase in Nat2 methylation, extending our previous observations that folate catabolism is decreased in Nat2 null mice.	Folic Acid	135-141	N-acetyltransferase 2 (arylamine N-acetyltransferase)	Mus musculus	76-80
19830782-0	2010	Expression of prostate-specific membrane antigen (PSMA), increases cell folate uptake and proliferation and suggests a novel role for PSMA in the uptake of the non-polyglutamated folate, folic acid.	Folic Acid	72-78	folate hydrolase 1	Homo sapiens	50-54
19830782-0	2010	Expression of prostate-specific membrane antigen (PSMA), increases cell folate uptake and proliferation and suggests a novel role for PSMA in the uptake of the non-polyglutamated folate, folic acid.	Folic Acid	179-185	folate hydrolase 1	Homo sapiens	50-54
19830782-0	2010	Expression of prostate-specific membrane antigen (PSMA), increases cell folate uptake and proliferation and suggests a novel role for PSMA in the uptake of the non-polyglutamated folate, folic acid.	Folic Acid	179-185	folate hydrolase 1	Homo sapiens	134-138
19830782-0	2010	Expression of prostate-specific membrane antigen (PSMA), increases cell folate uptake and proliferation and suggests a novel role for PSMA in the uptake of the non-polyglutamated folate, folic acid.	Folic Acid	187-197	folate hydrolase 1	Homo sapiens	50-54
19830782-0	2010	Expression of prostate-specific membrane antigen (PSMA), increases cell folate uptake and proliferation and suggests a novel role for PSMA in the uptake of the non-polyglutamated folate, folic acid.	Folic Acid	187-197	folate hydrolase 1	Homo sapiens	134-138
19830782-3	2010	As PSMA is able to hydrolyze polyglutamated folates, and cancer cells proliferate directly in response to available folate, we examined if expression of human PSMA in PC-3 cells confers a proliferative advantage in a microenvironment with physiologically relevant folate levels.	Folic Acid	44-50	folate hydrolase 1	Homo sapiens	3-7
19830782-5	2010	Folic acid was tested for its ability to competitively inhibit the enzymatic activity of PSMA.	Folic Acid	0-10	folate hydrolase 1	Homo sapiens	89-93
19830782-7	2010	In media containing physiologic levels of folate, PSMA expression increased folic acid uptake approximately twofold over non-expressing cells.	Folic Acid	42-48	folate hydrolase 1	Homo sapiens	50-54
19830782-7	2010	In media containing physiologic levels of folate, PSMA expression increased folic acid uptake approximately twofold over non-expressing cells.	Folic Acid	76-86	folate hydrolase 1	Homo sapiens	50-54
19830782-8	2010	Folic acid was able to inhibit hydrolysis of N-[4-(phenylazo)-benzoyl]-glutamyl-gamma-glutamic acid (PABGgG) by PSMA in a competitive inhibition assay.	Folic Acid	0-10	folate hydrolase 1	Homo sapiens	112-116
19830782-9	2010	CONCLUSION: These findings implicate PSMA in both the metabolism of polyglutamated folates, and in the uptake of monoglutamated folates.	Folic Acid	83-90	folate hydrolase 1	Homo sapiens	37-41
19830782-9	2010	CONCLUSION: These findings implicate PSMA in both the metabolism of polyglutamated folates, and in the uptake of monoglutamated folates.	Folic Acid	128-135	folate hydrolase 1	Homo sapiens	37-41
19962972-8	2010	The modifications of apoprotein conformation and physico-chemical properties in Hcy-HDL and the decrease of paraoxonase-1 activity could affect the protective effect of HDL against oxidative damage and/or homocysteinylation and could contribute to accelerated atherosclerosis in patients affected by diseases associated with oxidative damage, in renal disorders and in patients affected by genetic or nutritional disorders of homocysteine or folate metabolism.	Folic Acid	442-448	paraoxonase 1	Homo sapiens	108-121
19969375-7	2010	This study, using a unique cohort, provided a broader mechanism (disturbed folic acid-vitamin B12-DHA balance) of altered one-carbon metabolism and one of its key consequential components, an increased homocysteine level that together with cortisol, can contribute to the neuropathology of psychosis.	Folic Acid	75-85	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	94-97
20805077-9	2010	In vitamin B12 insufficient, folate replete pregnant women, vitamin B12 supplementation is associated with a reduction of plasma total homocysteine concentration in late pregnancy.	Folic Acid	29-35	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	68-71
19660435-10	2010	Mutagenesis experiments have revealed that charged amino acids were essential for FT1 stability or activity and led to a plausible model for the transport of folic acid through FT1.	Folic Acid	158-168	AKT interacting protein	Homo sapiens	82-85
19660435-10	2010	Mutagenesis experiments have revealed that charged amino acids were essential for FT1 stability or activity and led to a plausible model for the transport of folic acid through FT1.	Folic Acid	158-168	AKT interacting protein	Homo sapiens	177-180
21125813-3	2010	The present study was aimed to evaluate the efficacy of folic acid (CAS 59-30-3) in prevention of apoptosis by inhibiting TNF-alpha action in ischemia-reperfusion (I/R) induced liver injury.	Folic Acid	56-66	tumor necrosis factor	Rattus norvegicus	122-131
21125813-14	2010	The present study demonstrated that elevated TNF-alpha activity directly related to apoptosis and folic acid inhibits apoptosis by inhibiting the action of TNF-alpha.	Folic Acid	98-108	tumor necrosis factor	Rattus norvegicus	156-165
20622459-6	2010	The results indicate that the antioxidants have different capacities to prevent eEF-2 loss, folic acid being the most effective.	Folic Acid	92-102	eukaryotic translation elongation factor 2	Rattus norvegicus	80-85
19737897-4	2010	In this study, we characterized the innate immune response elicited by PGA in the human monocytic cell line THP-1, which was differentiated into macrophages with phorbol 12-myristate 13-acetate (PMA) and human monocyte-derived dendritic cells (hMoDCs).	Folic Acid	71-74	GLI family zinc finger 2	Homo sapiens	108-113
19360465-3	2010	Of the analyzed genes, ERCC2, XRCC1, XRCC2, XRCC3 and Lig4 participate in DNA repair, TP53 in cell cycle check point control, AIB1, AR, COMT, CYP11A1, CYP17A1, CYP19A1, HSD17 and PGR in steroid hormone biosynthesis/metabolism/signaling, TYMS in folate metabolism and HER2, IL6, LRP1, TGFB and TGFBR1 affect cell growth.	Folic Acid	245-251	tumor protein p53	Homo sapiens	86-90
19360465-3	2010	Of the analyzed genes, ERCC2, XRCC1, XRCC2, XRCC3 and Lig4 participate in DNA repair, TP53 in cell cycle check point control, AIB1, AR, COMT, CYP11A1, CYP17A1, CYP19A1, HSD17 and PGR in steroid hormone biosynthesis/metabolism/signaling, TYMS in folate metabolism and HER2, IL6, LRP1, TGFB and TGFBR1 affect cell growth.	Folic Acid	245-251	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	142-149
19360465-3	2010	Of the analyzed genes, ERCC2, XRCC1, XRCC2, XRCC3 and Lig4 participate in DNA repair, TP53 in cell cycle check point control, AIB1, AR, COMT, CYP11A1, CYP17A1, CYP19A1, HSD17 and PGR in steroid hormone biosynthesis/metabolism/signaling, TYMS in folate metabolism and HER2, IL6, LRP1, TGFB and TGFBR1 affect cell growth.	Folic Acid	245-251	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	160-167
19360465-3	2010	Of the analyzed genes, ERCC2, XRCC1, XRCC2, XRCC3 and Lig4 participate in DNA repair, TP53 in cell cycle check point control, AIB1, AR, COMT, CYP11A1, CYP17A1, CYP19A1, HSD17 and PGR in steroid hormone biosynthesis/metabolism/signaling, TYMS in folate metabolism and HER2, IL6, LRP1, TGFB and TGFBR1 affect cell growth.	Folic Acid	245-251	erb-b2 receptor tyrosine kinase 2	Homo sapiens	267-271
19360465-3	2010	Of the analyzed genes, ERCC2, XRCC1, XRCC2, XRCC3 and Lig4 participate in DNA repair, TP53 in cell cycle check point control, AIB1, AR, COMT, CYP11A1, CYP17A1, CYP19A1, HSD17 and PGR in steroid hormone biosynthesis/metabolism/signaling, TYMS in folate metabolism and HER2, IL6, LRP1, TGFB and TGFBR1 affect cell growth.	Folic Acid	245-251	interleukin 6	Homo sapiens	273-276
19360465-3	2010	Of the analyzed genes, ERCC2, XRCC1, XRCC2, XRCC3 and Lig4 participate in DNA repair, TP53 in cell cycle check point control, AIB1, AR, COMT, CYP11A1, CYP17A1, CYP19A1, HSD17 and PGR in steroid hormone biosynthesis/metabolism/signaling, TYMS in folate metabolism and HER2, IL6, LRP1, TGFB and TGFBR1 affect cell growth.	Folic Acid	245-251	LDL receptor related protein 1	Homo sapiens	278-282
19360465-3	2010	Of the analyzed genes, ERCC2, XRCC1, XRCC2, XRCC3 and Lig4 participate in DNA repair, TP53 in cell cycle check point control, AIB1, AR, COMT, CYP11A1, CYP17A1, CYP19A1, HSD17 and PGR in steroid hormone biosynthesis/metabolism/signaling, TYMS in folate metabolism and HER2, IL6, LRP1, TGFB and TGFBR1 affect cell growth.	Folic Acid	245-251	transforming growth factor beta 1	Homo sapiens	284-288
20798494-8	2010	The tHcy levels were significantly and inversely correlated with folate levels in the TNF-alpha-308GG and TNF-alpha-238GG genotypes in the ischemic stroke, SBI, and control groups (p&lt; 0.05).	Folic Acid	65-71	tumor necrosis factor	Homo sapiens	86-95
19764999-8	2009	Folate levels in tumors correlated positively with LINE-1, CDH13, and RUNX3 methylation.	Folic Acid	0-6	cadherin 13	Homo sapiens	59-64
19446551-3	2009	We found that the expression and function of FRalpha were strongly up-regulated, by Western blotting and folic acid binding assay.	Folic Acid	105-115	rabaptin, RAB GTPase binding effector protein 2	Mus musculus	45-52
19446551-6	2009	These effects were abrogated in the same alphaT3-1 cells when transfected with a mutant FRalpha cDNA that confers a dominant-negative phenotype by inhibiting folic acid binding.	Folic Acid	158-168	rabaptin, RAB GTPase binding effector protein 2	Mus musculus	88-95
20021721-2	2009	It has been previously demonstrated that folate and vitamin B(12) treatment improved insulin resistance in patients with metabolic syndrome.	Folic Acid	41-47	insulin	Homo sapiens	85-92
21045269-1	2010	This study aimed to investigate the role of maternal polymorphisms, as well as their risk genotypes combinations of MTR A2756G, MTRR A66G, CBS 844ins68, and RFC A80G, involved in folate/homocysteine metabolism, as possible risk factors for Down syndrome (DS) in Southern Brazil.	Folic Acid	179-185	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	128-132
19737897-6	2010	PGA treatment of differentiated THP-1 cells and hMoDCs led to the specific extracellular release of interleukin-1beta (IL-1beta) in a dose-dependent manner.	Folic Acid	0-3	interleukin 1 beta	Homo sapiens	100-117
19737897-6	2010	PGA treatment of differentiated THP-1 cells and hMoDCs led to the specific extracellular release of interleukin-1beta (IL-1beta) in a dose-dependent manner.	Folic Acid	0-3	interleukin 1 beta	Homo sapiens	119-127
19737897-7	2010	Evaluation of IL-1beta processing by Western blotting revealed that cleaved IL-1beta increased in THP-1 cells and hMoDCs after PGA treatment.	Folic Acid	127-130	interleukin 1 beta	Homo sapiens	14-22
19737897-7	2010	Evaluation of IL-1beta processing by Western blotting revealed that cleaved IL-1beta increased in THP-1 cells and hMoDCs after PGA treatment.	Folic Acid	127-130	interleukin 1 beta	Homo sapiens	76-84
19737897-7	2010	Evaluation of IL-1beta processing by Western blotting revealed that cleaved IL-1beta increased in THP-1 cells and hMoDCs after PGA treatment.	Folic Acid	127-130	GLI family zinc finger 2	Homo sapiens	98-103
19737897-9	2010	The extracellular release of IL-1beta in response to PGA was ICE dependent, since the administration of an ICE inhibitor prior to PGA treatment blocked induction of IL-1beta.	Folic Acid	53-56	interleukin 1 beta	Homo sapiens	29-37
19737897-9	2010	The extracellular release of IL-1beta in response to PGA was ICE dependent, since the administration of an ICE inhibitor prior to PGA treatment blocked induction of IL-1beta.	Folic Acid	53-56	caspase 1	Homo sapiens	61-64
19737897-9	2010	The extracellular release of IL-1beta in response to PGA was ICE dependent, since the administration of an ICE inhibitor prior to PGA treatment blocked induction of IL-1beta.	Folic Acid	53-56	caspase 1	Homo sapiens	107-110
19737897-9	2010	The extracellular release of IL-1beta in response to PGA was ICE dependent, since the administration of an ICE inhibitor prior to PGA treatment blocked induction of IL-1beta.	Folic Acid	53-56	interleukin 1 beta	Homo sapiens	165-173
19737897-9	2010	The extracellular release of IL-1beta in response to PGA was ICE dependent, since the administration of an ICE inhibitor prior to PGA treatment blocked induction of IL-1beta.	Folic Acid	130-133	interleukin 1 beta	Homo sapiens	29-37
19737897-9	2010	The extracellular release of IL-1beta in response to PGA was ICE dependent, since the administration of an ICE inhibitor prior to PGA treatment blocked induction of IL-1beta.	Folic Acid	130-133	caspase 1	Homo sapiens	61-64
19737897-9	2010	The extracellular release of IL-1beta in response to PGA was ICE dependent, since the administration of an ICE inhibitor prior to PGA treatment blocked induction of IL-1beta.	Folic Acid	130-133	interleukin 1 beta	Homo sapiens	165-173
19737897-11	2010	anthracis PGA elicits IL-1beta production through activation of ICE in PMA-differentiated THP-1 cells and hMoDCs, suggesting the potential for PGA as a therapeutic target for anthrax.	Folic Acid	10-13	interleukin 1 beta	Homo sapiens	22-30
19737897-11	2010	anthracis PGA elicits IL-1beta production through activation of ICE in PMA-differentiated THP-1 cells and hMoDCs, suggesting the potential for PGA as a therapeutic target for anthrax.	Folic Acid	10-13	caspase 1	Homo sapiens	64-67
19737897-11	2010	anthracis PGA elicits IL-1beta production through activation of ICE in PMA-differentiated THP-1 cells and hMoDCs, suggesting the potential for PGA as a therapeutic target for anthrax.	Folic Acid	10-13	GLI family zinc finger 2	Homo sapiens	90-95
23554608-0	2010	The preparation and characterization of folate-conjugated human serum albumin magnetic cisplatin nanoparticles.	Folic Acid	40-46	albumin	Homo sapiens	64-77
23554608-2	2010	To evaluate the importance of folate-conjugated human serum albumin (HSA) magnetic nanoparticles (Folate-CDDP/HSA MNP), we prepared drug-loaded Folate-CDDP/HSA MNPs and characterized their features.	Folic Acid	30-36	albumin	Homo sapiens	54-67
23554608-2	2010	To evaluate the importance of folate-conjugated human serum albumin (HSA) magnetic nanoparticles (Folate-CDDP/HSA MNP), we prepared drug-loaded Folate-CDDP/HSA MNPs and characterized their features.	Folic Acid	98-104	albumin	Homo sapiens	54-67
19694922-16	2010	In case of hyperhomocysteinemia associated with low levels of folates, the administration of PDE5 inhibitors may fail if not preceded by the correction of the alterated levels of Hcy and folates.	Folic Acid	62-69	phosphodiesterase 5A	Homo sapiens	93-97
19694922-16	2010	In case of hyperhomocysteinemia associated with low levels of folates, the administration of PDE5 inhibitors may fail if not preceded by the correction of the alterated levels of Hcy and folates.	Folic Acid	187-194	phosphodiesterase 5A	Homo sapiens	93-97
19951991-4	2009	The acquisition of folate uptake ability by macrophages is promoted by M-CSF, maintained by IL-4, prevented by GM-CSF, and reduced by IFNgamma, indicating a link between FRbeta expression and M2 polarization.	Folic Acid	19-25	interleukin 4	Homo sapiens	92-96
19951991-4	2009	The acquisition of folate uptake ability by macrophages is promoted by M-CSF, maintained by IL-4, prevented by GM-CSF, and reduced by IFNgamma, indicating a link between FRbeta expression and M2 polarization.	Folic Acid	19-25	interferon gamma	Homo sapiens	134-142
19822838-5	2009	Among individuals not receiving folic acid, there was a 4% decrease (mean ratio of year 3 to baseline levels = 0.96, 95% confidence interval [CI] = 0.82 to 1.14) in CRP for a period of 3 years in the 325 mg of aspirin group vs a 20% increase (mean ratio = 1.20, 95% CI = 1.03 to 1.41) in the placebo group (P = .027).	Folic Acid	32-42	C-reactive protein	Homo sapiens	165-168
19822838-8	2009	Low-dose aspirin (325 mg/d) is beneficial in stabilizing CRP levels, which may be abrogated by folate.	Folic Acid	95-101	C-reactive protein	Homo sapiens	57-60
19409716-1	2009	Reduced folates have been shown to reconstitute the proper activity of "uncoupled" endothelial nitric oxide synthase in inflamed endothlelium.	Folic Acid	8-15	nitric oxide synthase 3	Homo sapiens	83-116
19737897-6	2010	PGA treatment of differentiated THP-1 cells and hMoDCs led to the specific extracellular release of interleukin-1beta (IL-1beta) in a dose-dependent manner.	Folic Acid	0-3	GLI family zinc finger 2	Homo sapiens	32-37
19640582-0	2009	The suppression of lung tumorigenesis by aerosol-delivered folate-chitosan-graft-polyethylenimine/Akt1 shRNA complexes through the Akt signaling pathway.	Folic Acid	59-65	AKT serine/threonine kinase 1	Homo sapiens	98-102
19593106-3	2009	Changes in activity of a critical folate-metabolizing enzyme, methylenetetrahydrofolate reductase (MTHFR), might alter the chemosensitivity to MTX, as the MTHFR substrate is required for nucleotide synthesis and its product is used in homocysteine remethylation to methionine.	Folic Acid	34-40	methylenetetrahydrofolate reductase	Mus musculus	62-97
19593106-3	2009	Changes in activity of a critical folate-metabolizing enzyme, methylenetetrahydrofolate reductase (MTHFR), might alter the chemosensitivity to MTX, as the MTHFR substrate is required for nucleotide synthesis and its product is used in homocysteine remethylation to methionine.	Folic Acid	34-40	methylenetetrahydrofolate reductase	Mus musculus	99-104
19593106-3	2009	Changes in activity of a critical folate-metabolizing enzyme, methylenetetrahydrofolate reductase (MTHFR), might alter the chemosensitivity to MTX, as the MTHFR substrate is required for nucleotide synthesis and its product is used in homocysteine remethylation to methionine.	Folic Acid	34-40	methylenetetrahydrofolate reductase	Mus musculus	155-160
19765810-7	2009	Pathway analysis revealed these genes are overrepresented for components of insulin and hedgehog signaling, the cell cycle, and the folate metabolism.	Folic Acid	132-138	insulin	Homo sapiens	76-83
19640582-0	2009	The suppression of lung tumorigenesis by aerosol-delivered folate-chitosan-graft-polyethylenimine/Akt1 shRNA complexes through the Akt signaling pathway.	Folic Acid	59-65	AKT serine/threonine kinase 1	Homo sapiens	98-101
19738041-0	2009	Structural basis for the inhibition of human 5,10-methenyltetrahydrofolate synthetase by N10-substituted folate analogues.	Folic Acid	68-74	nuclear receptor subfamily 4 group A member 1	Homo sapiens	89-92
19761653-0	2009	Folate stimulates ERK1/2 phosphorylation and cell proliferation in fetal neural stem cells.	Folic Acid	0-6	mitogen-activated protein kinase 3	Homo sapiens	18-24
19761653-3	2009	In this study, we have investigated the effect of folate on extracellular signal-regulated kinase (ERK1/2) phosphorylation, cell proliferation and apoptosis in fetal NSCs.	Folic Acid	50-56	mitogen-activated protein kinase 3	Homo sapiens	99-105
19761653-4	2009	The results showed that treatment of neurospheres with folate increased ERK1/2 phosphorylation and cell proliferation in a concentration-dependent manner.	Folic Acid	55-61	mitogen-activated protein kinase 3	Homo sapiens	72-78
19322672-0	2009	Folate biofortification of lettuce by expression of a codon optimized chicken GTP cyclohydrolase I gene.	Folic Acid	0-6	GTP cyclohydrolase 1	Gallus gallus	78-98
20641404-4	2004	PSMA may play an important role in the progression of prostate cancer and glutamatergic neurotransmission, and in the absorption of folate (4).	Folic Acid	132-138	folate hydrolase 1	Homo sapiens	0-4
19738041-6	2009	Binding of N10-substituted folate analogues places Y152 in the middle of the channel connecting ATP binding site with the substrate binding pocket, precluding the positioning of gamma-phosphate for a nucleophilic attack.	Folic Acid	27-33	nuclear receptor subfamily 4 group A member 1	Homo sapiens	11-14
19639185-8	2009	Conversely thalidomide and PGA induced down-regulation of VEGF gene expression in both drug-sensitive and -resistant myeloma cells.	Folic Acid	27-30	vascular endothelial growth factor A	Homo sapiens	58-62
18926688-4	2009	Compound heterozygous mice (Folbp1(+/-); RFC1(+/-)) fed an adequate folate diet exhibited a reduction in plasma folate concentrations compared to heterozygous (Folbp1(+/-)) and littermate wild-type mice (P&lt;.05).	Folic Acid	112-118	replication factor C (activator 1) 1	Mus musculus	41-45
19657138-2	2009	The main regulating enzymes in folate and homocysteine metabolism are methylenetetrahydrofolate reductase (MTHFR) and cystathionine beta-synthase (CBS).	Folic Acid	31-37	cystathionine beta-synthase	Homo sapiens	118-145
19657138-2	2009	The main regulating enzymes in folate and homocysteine metabolism are methylenetetrahydrofolate reductase (MTHFR) and cystathionine beta-synthase (CBS).	Folic Acid	31-37	cystathionine beta-synthase	Homo sapiens	147-150
19644884-7	2009	RESULTS: Folic acid inhibited aldehyde oxidase (AO), the enzyme that produces 7-OH-MTX, but folinic acid did not.	Folic Acid	9-19	aldehyde oxidase 1	Homo sapiens	30-46
19644884-7	2009	RESULTS: Folic acid inhibited aldehyde oxidase (AO), the enzyme that produces 7-OH-MTX, but folinic acid did not.	Folic Acid	9-19	aldehyde oxidase 1	Homo sapiens	48-50
19644884-13	2009	Decreased 7-OH-MTX formation suggests folic acid inhibition of AO and a better clinical response, while increased 7-OH-MTX formation may interfere with MTX polyglutamylation and binding to enzymes and, therefore, may increase MTX excretion and decrease MTX retention and efficacy in vivo.	Folic Acid	38-48	aldehyde oxidase 1	Homo sapiens	63-65
20929023-12	2009	Seventy-one percent of folate-deficient patients had vitamin B12 deficiency as well, while 26.1% of patients with B12 deficiency had a co-occurrence of folate deficiency.	Folic Acid	23-29	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	61-64
19457069-3	2009	Previous studies demonstrate that deprivation of folate and vitamin E, coupled with dietary iron as a pro-oxidant, for 1 month displayed increased presenilin 1 (PS-1) expression, gamma-secretase, and Abeta generation in mice lacking ApoE (ApoE-/- mice).	Folic Acid	49-55	apolipoprotein E	Mus musculus	233-237
19457069-3	2009	Previous studies demonstrate that deprivation of folate and vitamin E, coupled with dietary iron as a pro-oxidant, for 1 month displayed increased presenilin 1 (PS-1) expression, gamma-secretase, and Abeta generation in mice lacking ApoE (ApoE-/- mice).	Folic Acid	49-55	apolipoprotein E	Mus musculus	239-251
19669235-6	2009	This compliments previous reports that folate is important for milk protein synthesis and suggests FOLR1 may be a key regulatory point of folate metabolism for milk protein synthesis within mammary epithelial cells (lactocytes).	Folic Acid	39-45	casein beta	Bos taurus	63-75
19669235-6	2009	This compliments previous reports that folate is important for milk protein synthesis and suggests FOLR1 may be a key regulatory point of folate metabolism for milk protein synthesis within mammary epithelial cells (lactocytes).	Folic Acid	138-144	casein beta	Bos taurus	160-172
19798971-0	2009	[Spectroscopic study on binding of folic acid to human serum albumin].	Folic Acid	35-45	albumin	Homo sapiens	61-68
19798971-1	2009	The interaction of human serum albumin and folic acid was studied using fluorescence spectroscopy, UV absorption and synchronous fluorescence spectroscopy in the pH 7.4 Tris-HCl buffer system at different temperatures.	Folic Acid	43-53	albumin	Homo sapiens	31-38
19152916-0	2009	The up-regulation of monocyte chemoattractant protein-1 (MCP-1) in Ea.hy 926 endothelial cells under long-term low folate stress is mediated by the p38 MAPK pathway.	Folic Acid	115-121	mitogen-activated protein kinase 14	Homo sapiens	148-151
19152916-5	2009	This quantitative transcriptional bias under chronic low folate conditions is not attributable to differences in active NF-kappaB, but is associated with elevated levels of both total p38 and phospho-p38 that are detectable by Western immunoblotting.	Folic Acid	57-63	mitogen-activated protein kinase 14	Homo sapiens	184-187
20929023-12	2009	Seventy-one percent of folate-deficient patients had vitamin B12 deficiency as well, while 26.1% of patients with B12 deficiency had a co-occurrence of folate deficiency.	Folic Acid	152-158	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	114-117
19174418-1	2009	BACKGROUND: Clinical studies suggest that mild methylenetetrahydrofolate reductase (MTHFR) deficiency and high dietary folate may reduce the risk for colorectal cancer.	Folic Acid	66-72	methylenetetrahydrofolate reductase	Mus musculus	84-89
19215022-1	2009	BACKGROUND: Despite extensive research on mild methylenetetrahydrofolate reductase (MTHFR) deficiency and low dietary folate in different disorders, the association of these metabolic disturbances with a variety of congenital defects and pregnancy complications remains controversial.	Folic Acid	66-72	methylenetetrahydrofolate reductase	Mus musculus	84-89
19649527-7	2009	CONCLUSION: The results indicate that MTHFR gene silencing effect EPM cell proliferation and cell apoptosis in the state of both MTHFR gene variants and insufficient folic acid supplement.	Folic Acid	166-176	methylenetetrahydrofolate reductase	Mus musculus	38-43
19234759-10	2009	Patients with DHPR deficiency also require folinic acid supplements, since DHPR may help in maintaining folate in the tetrahydro form.	Folic Acid	104-110	quinoid dihydropteridine reductase	Homo sapiens	14-18
19277036-0	2009	Impact of cellular folate status and epidermal growth factor receptor expression on BCRP/ABCG2-mediated resistance to gefitinib and erlotinib.	Folic Acid	19-25	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	84-88
19451595-5	2009	We also show that folate supplementation enhanced the DNA remethylation through the Sp1/Sp3-mediated transcriptional up-regulation of genes coding for Dnmt3a and Dnmt3b proteins, two de novo methyltranferases.	Folic Acid	18-24	Sp3 transcription factor	Homo sapiens	88-91
19484842-7	2009	There was a linear relationship between descending quartiles of folate concentrations and increasing odds of association with depressive symptoms, independent of other risk factors (demographic, psychosocial, alcohol and smoking, chronic morbidity, functional status, nutritional risk, albumin, anemia, depression-inducing medications, use of antidepressants and vitamin supplements), including B12 and homocysteine (P for trend=.02).	Folic Acid	64-70	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	395-398
19484842-8	2009	The odds ratio (OR) of association between low folate (lowest quartile: &lt;14.6 nmol/L) and depressive symptoms independent of other risk factors, including homocysteine and B12, was 1.72 (95% confidence interval (CI)=1.11-2.66).	Folic Acid	47-53	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	175-178
19484842-9	2009	Vitamin B12 across a range of values did not show a linear association, but B12 deficiency (&lt;180 pmol/L) appeared to be significantly associated with depressive symptoms (OR=2.68, 95% CI=1.20-6.00), independent of folate and homocysteine.	Folic Acid	217-223	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	76-79
19219535-0	2009	Association of genetic variants in Methylenetetrahydrofolate Reductase and Paraoxonase-1 genes with homocysteine, folate and vitamin B12 in coronary artery disease.	Folic Acid	54-60	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	133-136
19277036-2	2009	Caco-2 LF/LV cells, growing under low-folate (LF) conditions, showed increased BCRP protein expression compared with the high-folate (HF) counterpart, which was associated with 1.8-fold resistance to gefitinib.	Folic Acid	38-44	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	79-83
19277036-7	2009	Beyond this, folate depletion can provoke an additional decrease in gefitinib and erlotinib activity by mechanisms dependent or independent of BCRP modulation.	Folic Acid	13-19	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	143-147
19530270-2	2009	The cytotoxic T-lymphocyte antigen 4 (CTLA-4) gene was recently associated with AITD and PGA, and the CTLA-4 protein is a strong inhibitor of T-cells.The tumor necrosis factor alpha (TNF-alpha) is a proinflammatory cytokine.	Folic Acid	89-92	tumor necrosis factor	Homo sapiens	154-181
19530270-3	2009	This study aimed to analyze the association of the CTLA-4 CT60 and TNF-alpha-863 polymorphisms with PGA.	Folic Acid	100-103	long intergenic non-protein coding RNA 1193	Homo sapiens	58-62
19530270-3	2009	This study aimed to analyze the association of the CTLA-4 CT60 and TNF-alpha-863 polymorphisms with PGA.	Folic Acid	100-103	tumor necrosis factor	Homo sapiens	67-76
19530270-6	2009	The CT60 allele frequencies differed as well between PGA patients and controls, with the predisposing G allele being increased in PGA (OR = 1.63, 95 % CI = 1.03-2.55, p = 0.042).	Folic Acid	130-133	long intergenic non-protein coding RNA 1193	Homo sapiens	4-8
19277036-0	2009	Impact of cellular folate status and epidermal growth factor receptor expression on BCRP/ABCG2-mediated resistance to gefitinib and erlotinib.	Folic Acid	19-25	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	89-94
18848533-0	2009	FDH: an aldehyde dehydrogenase fusion enzyme in folate metabolism.	Folic Acid	48-54	aldehyde dehydrogenase 1 family member L1	Homo sapiens	0-3
19530270-8	2009	For TNF-alpha-863, carriers of the minor A allele occurred more frequently in the T1D group than in controls (47.1 % vs. 33 % , OR = 1.81, 95 % CI = 0.97-3.39, p = 0.079), but no differences in allele or genotype distribution were noted between PGA patients and controls (p = 0.886 and 0.389, respectively).	Folic Acid	245-248	tumor necrosis factor	Homo sapiens	4-13
19530270-9	2009	In conclusion the CTLA-4 CT60 polymorphism is associated with PGA.	Folic Acid	62-65	long intergenic non-protein coding RNA 1193	Homo sapiens	25-29
19130090-1	2009	Genetic variants in MTHFD1 (5,10-methylenetetrahydrofolate dehydrogenase/5,10-methenyltetrahydrofolate cyclohydrolase/ 10-formyltetrahydrofolate synthetase), an important folate metabolic enzyme, are associated with a number of common diseases, including neural tube defects (NTDs).	Folic Acid	52-58	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	20-26
19248856-8	2009	Serum C-reactive protein was significantly inversely associated with intakes of fruit (r=-0.19; P=0.004), vitamin C (r=-0.13, P=0.03), and folate (r=-0.18; P=0.004).	Folic Acid	139-145	C-reactive protein	Homo sapiens	6-24
19176749-11	2009	Folate depletion in normal intestine may trigger neoplasia through increased DNA damage and defective apoptosis; upregulation of CD44 and gelsolin, and the mitochondrial apoptotic pathway are implicated.	Folic Acid	0-6	gelsolin	Mus musculus	138-146
19117321-4	2009	Among responsive mutants, folic acid supplementation reduces exencephaly and/or spina bifida aperta frequency in the Sp(2H), Sp, Cd, Cited2, Cart1, and Gcn5 mutants.	Folic Acid	26-36	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	Mus musculus	133-139
19117321-6	2009	The responsive Sp(2H) (Pax3) mutant has abnormal folate metabolism, but the responsive Cited2 mutant does not.	Folic Acid	49-55	paired box 3	Mus musculus	23-27
18602821-10	2009	The study shows a strong influence of folate status on Mtrr transcription in HepG2 cells.	Folic Acid	38-44	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	55-59
18848533-4	2009	The N-terminal domain of FDH (residues 1-310) carries the folate binding site and shares sequence homology and structural topology with other enzymes utilizing 10-formyl-THF as a substrate.	Folic Acid	58-64	aldehyde dehydrogenase 1 family member L1	Homo sapiens	25-28
19135973-4	2009	We proved that CB 3717/folate-induced ODC expression is Akt-dependent.	Folic Acid	23-29	thymoma viral proto-oncogene 1	Mus musculus	56-59
19152913-3	2009	Nutrient imbalance seems particularly important; for example, low maternal vitamin B(12) status coupled with high folate predicted higher adiposity and insulin resistance in Indian children, suggesting a role for 1-C (methyl) group donors in fetal programming.	Folic Acid	114-120	insulin	Homo sapiens	152-159
19240161-0	2009	Cellular folate status modulates the expression of BCRP and MRP multidrug transporters in cancer cell lines from different origins.	Folic Acid	9-15	ATP binding cassette subfamily C member 1	Homo sapiens	60-63
18800231-7	2009	The most predictive model of EPO response for the pediatric cohort had, as the major variables, urea clearance x dialysis duration/total body water (Kt/V), urea reduction ratio (URR), intact parathyroid hormone (iPTH), blood loss, normalized protein catabolic rates (nPCR) and indices of malnutrition and inflammation, whereas adults had iron and folate deficiencies as the dominant variables.	Folic Acid	347-353	erythropoietin	Homo sapiens	29-32
18800231-10	2009	In summary EPO resistance in the pediatric dialysis cohort was predicted by nutritional deficits, inflammation, poor dialysis, and hyperparathyroidism, while iron and folate deficits were the major determinants in adults.	Folic Acid	167-173	erythropoietin	Homo sapiens	11-14
19573437-0	2009	[Effects of folic acid and vitamin B12 in the enhanced preterm infants" hematopoiesis by intensified erythropoietin].	Folic Acid	12-22	erythropoietin	Homo sapiens	101-115
19116331-9	2009	CONCLUSIONS: Our study of predominantly supplement users suggests that high intakes of folate averaged over 10 y do not increase breast cancer risk, but may be protective, particularly against ER- breast cancers.	Folic Acid	87-93	estrogen receptor 1	Homo sapiens	193-195
19852428-5	2009	Molecular analysis of 12 genetic polymorphisms involved in the folate metabolism revealed that the mother is heterozygous for the MTHFR C677T and TC2 A67G polymorphisms, and homozygous for the mutant MTRR A66G polymorphism.	Folic Acid	63-69	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	200-204
19114857-10	2009	Children with elevated B12 were significantly more likely to be younger (P = 0.0002) and have higher mean folate levels (P = 0.0004) compared with children with normal serum B12.	Folic Acid	106-112	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	23-26
19811436-2	2009	We have analyzed whether the polymorphism of the proinflammatory cytokine gene TNF-alpha; -308 and mutations of the autoimmune regulator (AIRE) gene were associated with PGA in adults.	Folic Acid	170-173	tumor necrosis factor	Homo sapiens	79-88
20054435-0	2009	Optimization of the preparation process of vinblastine sulfate (VBLS)-loaded folate-conjugated bovine serum albumin (BSA) nanoparticles for tumor-targeted drug delivery using response surface methodology (RSM).	Folic Acid	77-83	albumin	Homo sapiens	102-115
19098360-0	2008	Folate and S-adenosylmethionine modulate synaptic activity in cultured cortical neurons: acute differential impact on normal and apolipoprotein-deficient mice.	Folic Acid	0-6	apolipoprotein E	Mus musculus	129-143
19098360-1	2008	Folate deficiency is accompanied by a decline in the cognitive neurotransmitter acetylcholine and a decline in cognitive performance in mice lacking apolipoprotein E (ApoE-/- mice), a low-density lipoprotein that regulates aspects of lipid metabolism.	Folic Acid	0-6	apolipoprotein E	Mus musculus	149-165
19098360-1	2008	Folate deficiency is accompanied by a decline in the cognitive neurotransmitter acetylcholine and a decline in cognitive performance in mice lacking apolipoprotein E (ApoE-/- mice), a low-density lipoprotein that regulates aspects of lipid metabolism.	Folic Acid	0-6	apolipoprotein E	Mus musculus	167-171
19098360-8	2008	Folate deprivation reversibly reduced signal frequency in ApoE+/+ cultures; SAM supplementation maintained signal frequency despite folate deprivation.	Folic Acid	0-6	apolipoprotein E	Mus musculus	58-62
20641595-4	2004	PSMA may play an important role in the progression of prostate cancer, glutamatergic neurotransmission, and in the absorption of folate (4).	Folic Acid	129-135	folate hydrolase 1	Homo sapiens	0-4
19064560-3	2008	We examined the association between dietary folate intake and the risk of breast cancer by estrogen receptor (ER) and progesterone receptor (PR) status of the breast tumor in the Swedish Mammography Cohort.	Folic Acid	44-50	estrogen receptor 1	Homo sapiens	91-108
19064560-3	2008	We examined the association between dietary folate intake and the risk of breast cancer by estrogen receptor (ER) and progesterone receptor (PR) status of the breast tumor in the Swedish Mammography Cohort.	Folic Acid	44-50	estrogen receptor 1	Homo sapiens	110-112
19064560-9	2008	However, folate intake was inversely associated with risk of ER+/PR- breast cancer (n = 417 cases; RR for highest versus lowest quintile, 0.79; 95% CI, 0.59-1.07; P(trend) = 0.01).	Folic Acid	9-15	estrogen receptor 1	Homo sapiens	61-63
18753144-0	2008	Gene-environment interactions in the causation of neural tube defects: folate deficiency increases susceptibility conferred by loss of Pax3 function.	Folic Acid	71-77	paired box 3	Mus musculus	135-139
18974153-8	2008	Ectopic PSMA expression on PC-3 cells increased the invasive capacity of cells in in vitro invasion assays, which could be competed out by folic acid.	Folic Acid	139-149	folate hydrolase 1	Homo sapiens	8-12
18974153-9	2008	These results suggest PSMA facilitates the development of prostate cancer, and the invasive ability of these cells may be modulated by folate levels.	Folic Acid	135-141	folate hydrolase 1	Homo sapiens	22-26
18974153-10	2008	These findings show a novel mechanism that may contribute to the known role of folate in cancer prevention, and may lead to the use of PSMA inhibitors as novel chemopreventive agents for prostate cancer.	Folic Acid	79-85	folate hydrolase 1	Homo sapiens	135-139
18430556-6	2008	The neurotoxicity of homocysteine was attenuated by the treatment of cells with folate, as determined by caspase-3 activity and apoptotic body staining.	Folic Acid	80-86	caspase 3	Homo sapiens	105-114
18653314-8	2008	CONCLUSION: Serum folate concentrations in the highest quintile among healthy humans are associated with increased erythrocyte SAM and SAH concentrations, but not with SAM/SAH ratio or with methylation levels of CpG sites across the promoter region of the ec-SOD gene.	Folic Acid	18-24	superoxide dismutase 3	Homo sapiens	256-262
18697859-6	2008	By genetically increasing serum and liver total cholesterol levels in APOE-deficient mice, we modestly but significantly improved folate retention during folate depletion, suggesting that homeostasis among the homocysteine, folate and cholesterol metabolic pathways contributes to the beneficial effects of dietary folate supplementation.	Folic Acid	130-136	apolipoprotein E	Mus musculus	70-74
18697859-6	2008	By genetically increasing serum and liver total cholesterol levels in APOE-deficient mice, we modestly but significantly improved folate retention during folate depletion, suggesting that homeostasis among the homocysteine, folate and cholesterol metabolic pathways contributes to the beneficial effects of dietary folate supplementation.	Folic Acid	154-160	apolipoprotein E	Mus musculus	70-74
18697859-6	2008	By genetically increasing serum and liver total cholesterol levels in APOE-deficient mice, we modestly but significantly improved folate retention during folate depletion, suggesting that homeostasis among the homocysteine, folate and cholesterol metabolic pathways contributes to the beneficial effects of dietary folate supplementation.	Folic Acid	154-160	apolipoprotein E	Mus musculus	70-74
18697859-6	2008	By genetically increasing serum and liver total cholesterol levels in APOE-deficient mice, we modestly but significantly improved folate retention during folate depletion, suggesting that homeostasis among the homocysteine, folate and cholesterol metabolic pathways contributes to the beneficial effects of dietary folate supplementation.	Folic Acid	154-160	apolipoprotein E	Mus musculus	70-74
18842806-6	2008	DESIGN: Thirteen single nucleotide polymorphisms (SNPs) in genes involved in folate uptake and metabolism, including folate hydrolase (FOLH1), folate polyglutamate synthase (FPGS), gamma-glutamyl hydrolase (GGH), methylene tetrahydrofolate reductase (MTHFR), methionine synthase (MTR), proton-coupled folate transporter (PCFT), and reduced folate carrier (RFC1), were studied in a cohort of 991 individuals.	Folic Acid	77-83	folate hydrolase 1	Homo sapiens	135-140
19433897-2	2009	In the present report, mice expressing human apolipoprotein E4 (associated with increased risk of AD) and apolipoprotein E3 were subjected to a diet lacking folate and vitamin E, and containing iron as a pro-oxidant.	Folic Acid	157-163	apolipoprotein E	Homo sapiens	45-62
19147541-11	2009	JNK activation in response to FDH was inhibited by high supplementation of reduced folate leucovorin, further indicating a functional connection between folate metabolism and mitogen-activated protein kinase pathways.	Folic Acid	83-89	mitogen-activated protein kinase 8	Homo sapiens	0-3
19147541-11	2009	JNK activation in response to FDH was inhibited by high supplementation of reduced folate leucovorin, further indicating a functional connection between folate metabolism and mitogen-activated protein kinase pathways.	Folic Acid	83-89	aldehyde dehydrogenase 1 family member L1	Homo sapiens	30-33
19147541-11	2009	JNK activation in response to FDH was inhibited by high supplementation of reduced folate leucovorin, further indicating a functional connection between folate metabolism and mitogen-activated protein kinase pathways.	Folic Acid	153-159	mitogen-activated protein kinase 8	Homo sapiens	0-3
19147541-11	2009	JNK activation in response to FDH was inhibited by high supplementation of reduced folate leucovorin, further indicating a functional connection between folate metabolism and mitogen-activated protein kinase pathways.	Folic Acid	153-159	aldehyde dehydrogenase 1 family member L1	Homo sapiens	30-33
18826993-6	2008	Together with widespread use of supplemental multivitamins, fortification of the US diet with folic acid has resulted in high serum folate levels in much of the population, which may be associated with increased risk of cognitive decline in ageing people with low vitamin B12 status, decreased natural killer T-cell immune function and increased risk of recurrent advanced precancerous colorectal adenomas and breast cancer.	Folic Acid	94-104	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	272-275
18177869-0	2008	Association between folate metabolism-related gene polymorphisms and methylation of p16(INK4A) and hMLH1 genes in spontaneously aborted embryos with normal chromosomal integrity.	Folic Acid	20-26	cyclin dependent kinase inhibitor 2A	Homo sapiens	84-87
18177869-0	2008	Association between folate metabolism-related gene polymorphisms and methylation of p16(INK4A) and hMLH1 genes in spontaneously aborted embryos with normal chromosomal integrity.	Folic Acid	20-26	cyclin dependent kinase inhibitor 2A	Homo sapiens	88-93
19026946-13	2008	CONCLUSION: Fluorescence imaging could be used to semiquantitatively monitor tumor size, whereas PET could be used to monitor tumor response to therapeutic treatments, and especially, FLT might be a good marker of the response to anti-folate chemotherapeutics.	Folic Acid	235-241	fms related receptor tyrosine kinase 1	Homo sapiens	184-187
18843658-3	2008	Folic acid supplements may sometimes therefore include vitamin B12 supplements with simultaneous administration of vitamin B12.Lesser degrees of folate inadequacy are associated with high blood levels of the amino acid homocysteine which has been linked with the risk of arterial disease, dementia and Alzheimer"s disease.	Folic Acid	0-10	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	123-126
18843658-3	2008	Folic acid supplements may sometimes therefore include vitamin B12 supplements with simultaneous administration of vitamin B12.Lesser degrees of folate inadequacy are associated with high blood levels of the amino acid homocysteine which has been linked with the risk of arterial disease, dementia and Alzheimer"s disease.	Folic Acid	145-151	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	63-66
18843658-3	2008	Folic acid supplements may sometimes therefore include vitamin B12 supplements with simultaneous administration of vitamin B12.Lesser degrees of folate inadequacy are associated with high blood levels of the amino acid homocysteine which has been linked with the risk of arterial disease, dementia and Alzheimer"s disease.	Folic Acid	145-151	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	123-126
18843658-20	2008	Other trials involving people with cognitive impairment did not show any benefit in measures of cognitive function from folic acid, with or without vitamin B12.Folic acid plus vitamin B12 was effective in reducing serum homocysteine concentrations (WMD -5.90, 95% CI -8.43 to -3.37, P &lt; 0.00001).	Folic Acid	160-170	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	156-159
19811436-2	2009	We have analyzed whether the polymorphism of the proinflammatory cytokine gene TNF-alpha; -308 and mutations of the autoimmune regulator (AIRE) gene were associated with PGA in adults.	Folic Acid	170-173	autoimmune regulator	Homo sapiens	138-142
19811436-8	2009	PGA patients with autoimmune thyroid disease and the TNF-alpha; -308 AA genotype showed the highest prevalence of thyroid autoantibodies (TPO, P = 0.04; Tg, P = 0.003).	Folic Acid	0-3	tumor necrosis factor	Homo sapiens	53-62
19811436-9	2009	HLA-DRB1*03 and TNF-alpha; -308*A alleles were strongly associated in patients with PGA (87.5%, P(c) &lt; 0.00001).	Folic Acid	84-87	major histocompatibility complex, class II, DR beta 1	Homo sapiens	0-8
19811436-9	2009	HLA-DRB1*03 and TNF-alpha; -308*A alleles were strongly associated in patients with PGA (87.5%, P(c) &lt; 0.00001).	Folic Acid	84-87	tumor necrosis factor	Homo sapiens	16-25
19811436-11	2009	The association of TNF-alpha; -308*A with PGA might be directly or indirectly due to the association with HLA-DRB1*03.	Folic Acid	42-45	tumor necrosis factor	Homo sapiens	19-28
19811436-11	2009	The association of TNF-alpha; -308*A with PGA might be directly or indirectly due to the association with HLA-DRB1*03.	Folic Acid	42-45	major histocompatibility complex, class II, DR beta 1	Homo sapiens	106-114
18623116-1	2008	Folates can induce the expression and activity of the breast-cancer-resistance-protein (BCRP) and the multidrug-resistance-protein-1 (MRP1).	Folic Acid	0-7	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	88-92
18694616-9	2008	Serum vit B(12) concentrations were significantly associated with MS likelihood in women alone after adjustment for sex, age, smoking status, folate and antidiabetic medication.	Folic Acid	142-148	vitrin	Homo sapiens	6-9
18623116-0	2008	Folate deprivation induces BCRP (ABCG2) expression and mitoxantrone resistance in Caco-2 cells.	Folic Acid	0-6	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	27-31
18623116-0	2008	Folate deprivation induces BCRP (ABCG2) expression and mitoxantrone resistance in Caco-2 cells.	Folic Acid	0-6	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	33-38
18623116-1	2008	Folates can induce the expression and activity of the breast-cancer-resistance-protein (BCRP) and the multidrug-resistance-protein-1 (MRP1).	Folic Acid	0-7	ATP binding cassette subfamily B member 1	Homo sapiens	102-132
18623116-1	2008	Folates can induce the expression and activity of the breast-cancer-resistance-protein (BCRP) and the multidrug-resistance-protein-1 (MRP1).	Folic Acid	0-7	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	54-86
18623116-1	2008	Folates can induce the expression and activity of the breast-cancer-resistance-protein (BCRP) and the multidrug-resistance-protein-1 (MRP1).	Folic Acid	0-7	ATP binding cassette subfamily B member 1	Homo sapiens	134-138
18623116-2	2008	Our aim was to study the time-dependent effect of folate deprivation/supplementation on (i) BCRP and MRP expression and (ii) on drug resistance mediated by these transporters.	Folic Acid	50-56	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	92-96
18623116-2	2008	Our aim was to study the time-dependent effect of folate deprivation/supplementation on (i) BCRP and MRP expression and (ii) on drug resistance mediated by these transporters.	Folic Acid	50-56	ATP binding cassette subfamily C member 1	Homo sapiens	101-104
18623116-8	2008	In conclusion, folate deprivation induces BCRP expression associated with MR resistance in Caco-2 cells.	Folic Acid	15-21	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	42-46
18623116-9	2008	The intracellular localization of BCRP in these cells suggests that this transporter is not primarily extruding its substrates out of the cell, but rather to an intracellular compartment where folates can be kept as storage.	Folic Acid	193-200	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	34-38
18781288-12	2008	CONCLUSION: Short-term oral folic acid (5 mg/day) supplementation with or without methylcobalamin appeared to be an effective approach to decrease Hcy levels and increase HTase/PON activity in patients with type 2 diabetes.	Folic Acid	28-38	paraoxonase 1	Homo sapiens	177-180
18830563-4	2008	By using a natural stable folate we were able to reverse the EGCG suppression of TNF-alpha-induced NF-kappaB activation, the phosphorylation and degradation of IkappaBalpha and the phosphorylation of Akt in this human colon carcinoma cell line.	Folic Acid	26-32	tumor necrosis factor	Homo sapiens	81-90
18830563-4	2008	By using a natural stable folate we were able to reverse the EGCG suppression of TNF-alpha-induced NF-kappaB activation, the phosphorylation and degradation of IkappaBalpha and the phosphorylation of Akt in this human colon carcinoma cell line.	Folic Acid	26-32	nuclear factor kappa B subunit 1	Homo sapiens	99-108
18830563-4	2008	By using a natural stable folate we were able to reverse the EGCG suppression of TNF-alpha-induced NF-kappaB activation, the phosphorylation and degradation of IkappaBalpha and the phosphorylation of Akt in this human colon carcinoma cell line.	Folic Acid	26-32	NFKB inhibitor alpha	Homo sapiens	160-172
18830563-4	2008	By using a natural stable folate we were able to reverse the EGCG suppression of TNF-alpha-induced NF-kappaB activation, the phosphorylation and degradation of IkappaBalpha and the phosphorylation of Akt in this human colon carcinoma cell line.	Folic Acid	26-32	AKT serine/threonine kinase 1	Homo sapiens	200-203
18615588-2	2008	Since methylenetetrahydrofolate reductase (MTHFR) is a key enzyme of folate interconversion and homocysteine metabolism, we addressed the possibility that VPA might have different teratogenicity in Mthfr(+/+) and Mthfr(+/-) mice and that VPA might interfere with folate metabolism through MTHFR modulation.	Folic Acid	25-31	methylenetetrahydrofolate reductase	Mus musculus	43-48
18615588-2	2008	Since methylenetetrahydrofolate reductase (MTHFR) is a key enzyme of folate interconversion and homocysteine metabolism, we addressed the possibility that VPA might have different teratogenicity in Mthfr(+/+) and Mthfr(+/-) mice and that VPA might interfere with folate metabolism through MTHFR modulation.	Folic Acid	69-75	methylenetetrahydrofolate reductase	Mus musculus	6-41
18615588-2	2008	Since methylenetetrahydrofolate reductase (MTHFR) is a key enzyme of folate interconversion and homocysteine metabolism, we addressed the possibility that VPA might have different teratogenicity in Mthfr(+/+) and Mthfr(+/-) mice and that VPA might interfere with folate metabolism through MTHFR modulation.	Folic Acid	69-75	methylenetetrahydrofolate reductase	Mus musculus	43-48
18842806-6	2008	DESIGN: Thirteen single nucleotide polymorphisms (SNPs) in genes involved in folate uptake and metabolism, including folate hydrolase (FOLH1), folate polyglutamate synthase (FPGS), gamma-glutamyl hydrolase (GGH), methylene tetrahydrofolate reductase (MTHFR), methionine synthase (MTR), proton-coupled folate transporter (PCFT), and reduced folate carrier (RFC1), were studied in a cohort of 991 individuals.	Folic Acid	117-123	folate hydrolase 1	Homo sapiens	135-140
18842806-9	2008	The FOLH1 1561C&gt;T SNP was associated with altered plasma folate concentrations.	Folic Acid	60-66	folate hydrolase 1	Homo sapiens	4-9
18501206-0	2008	Acetylation of N-terminal valine of glycine N-methyltransferase affects enzyme inhibition by folate.	Folic Acid	93-99	glycine N-methyltransferase	Homo sapiens	36-63
18501206-3	2008	Glycine N-methyltransferase is a regulatory enzyme mediating the availability of methyl groups by virtue of being inhibited by folate.	Folic Acid	127-133	glycine N-methyltransferase	Homo sapiens	0-27
18619459-0	2008	Folate and vitamin B6 intake and risk of colon cancer in relation to p53 expression.	Folic Acid	0-6	tumor protein p53	Homo sapiens	69-72
18070950-9	2008	Higher tHcy and lower folate concentrations correlated with impaired Delta RI(ALB) and increased CIMT.	Folic Acid	22-28	albumin	Homo sapiens	69-82
18070950-10	2008	A 1 microg/l increase in folate concentration was associated with 0.3 (95% CI 0.1 to 0.5) percentage point increase in Delta RI(ALB) and 0.002 (95% CI 0.001 to 0.006) mm decrease in CIMT, independent of blood pressure, smoking and vascular risk profile.	Folic Acid	25-31	albumin	Homo sapiens	119-132
18721738-13	2008	CONCLUSIONS: Composite scoring of erythrocyte indices was predictive of the FD diagnosis, as defined by the quantitative response of red blood cell folate, homocysteine, and EPO dose to folate therapeutic intervention.	Folic Acid	186-192	erythropoietin	Homo sapiens	174-177
18339680-6	2008	Among men, we observed strong positive associations between folate and BRAF-mutated tumors (RR = 3.04 for the highest versus lowest tertile of intake, P(trend) = 0.03) and between vitamin B6 and tumors showing MLH1 hypermethylation (highest versus lowest tertile: RR = 3.23, P(trend) = 0.03).	Folic Acid	60-66	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	71-75
18339680-7	2008	Among women, the relative risks of tumors with BRAF mutations or MLH1 hypermethylation were also increased in the highest tertiles of folate and vitamin B6 intake, respectively, but these did not reach statistical significance.	Folic Acid	134-140	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	47-51
18339680-8	2008	The positive associations between folate intake and tumors harboring BRAF mutations and between vitamin B6 intake and those showing MLH1 hypermethylation were most pronounced among men and may suggest that these vitamins enhance colorectal cancer risk through genetic as well as epigenetic aberrations.	Folic Acid	34-40	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	69-73
18619459-5	2008	The effect of folate differed significantly according to p53 expression (P(heterogeneity) = .01).	Folic Acid	14-20	tumor protein p53	Homo sapiens	57-60
18619459-9	2008	CONCLUSIONS: We found that low folate and vitamin B(6) intake was associated with an increased risk of p53-overexpressing colon cancers but not wild-type tumors.	Folic Acid	31-37	tumor protein p53	Homo sapiens	103-106
18661241-6	2008	Normal to high maternal folate status coupled with low vitamin B(12) status predicted higher adiposity and insulin resistance in Indian babies.	Folic Acid	24-30	insulin	Homo sapiens	107-114
18470605-7	2008	There was a dose-dependent reduction in the rate of cardiac myocyte apoptosis in the folic acid groups (P &lt; 0.01), and this was accompanied by an increased level of anti-apoptotic protein Bcl-2 and decreased level of pro-apoptotic protein Bax and Fas (P &lt; 0.01).	Folic Acid	85-95	BCL2, apoptosis regulator	Rattus norvegicus	191-196
18515090-9	2008	CONCLUSIONS: Our study suggested a common missense SNP of the MTRR gene as a novel pancreatic cancer susceptibility factor with a functional significance in folate-related metabolism and the genome-wide methylation status.	Folic Acid	157-163	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	62-66
18398434-2	2008	The effect of the cystathionine beta-synthase (CBS) 844ins68 polymorphism on homocysteine and folate concentrations was examined alone and in the context of the 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C&gt;T polymorphism in a Northwestern European male population.	Folic Acid	94-100	cystathionine beta-synthase	Homo sapiens	18-45
18383508-2	2008	In this study, embryonic/fetal development is characterized in an RFC1 knockout mouse model in which pregnant dams receive different levels of folate supplementation.	Folic Acid	143-149	replication factor C (activator 1) 1	Mus musculus	66-70
18383508-7	2008	Maternal folate supplementation with 50 mg/kg/day results in survival of 22% of RFC1 mutants to E18.5, but they develop with multiple malformations of the eyelids, lungs, heart, and skin.	Folic Acid	9-15	replication factor C (activator 1) 1	Mus musculus	80-84
18383508-8	2008	CONCLUSIONS: High doses of daily maternal folate supplementation during embryonic/fetal development are necessary for early postimplantation embryonic viability of RFC1 nullizygous embryos, and play a critical role in chorioallantoic fusion, erythropoiesis, and proper development of the neural tube, limbs, lungs, heart, and skin.	Folic Acid	42-48	replication factor C (activator 1) 1	Mus musculus	164-168
18599958-1	2008	When maintained on a folate-deficient, iron-rich diet, transgenic mice lacking in apolipoprotein E (ApoE-/- mice) demonstrate impaired activity of glutathione S-transferase (GST), resulting in increased oxidative species within brain tissue despite abnormally high levels of glutathione.	Folic Acid	21-27	apolipoprotein E	Mus musculus	82-98
18628437-7	2008	Polymorphisms that alter enzyme function of FTD, FTS, and MTCH are expected to affect purine synthesis, FTS more so under a low-folate status.	Folic Acid	128-134	AKT interacting protein	Homo sapiens	49-52
18628437-7	2008	Polymorphisms that alter enzyme function of FTD, FTS, and MTCH are expected to affect purine synthesis, FTS more so under a low-folate status.	Folic Acid	128-134	AKT interacting protein	Homo sapiens	104-107
18500934-8	2008	RESULTS: The target gene was identified among genes encoding a unique trifunctional enzyme in which DHPS is combined with the 2 preceding enzymes of the folate biosynthesis pathway.	Folic Acid	153-159	deoxyhypusine synthase	Homo sapiens	100-104
17941015-8	2008	The in vitro Rhodamine 123 efflux experiment using MDR KB(v200) cells revealed that when cells were pretreated with folate-attached and FG020326-loaded micelles, the P-glycoprotein (P-gp) drug efflux function was significantly inhibited.	Folic Acid	116-122	ATP binding cassette subfamily B member 1	Homo sapiens	166-180
17941015-8	2008	The in vitro Rhodamine 123 efflux experiment using MDR KB(v200) cells revealed that when cells were pretreated with folate-attached and FG020326-loaded micelles, the P-glycoprotein (P-gp) drug efflux function was significantly inhibited.	Folic Acid	116-122	ATP binding cassette subfamily B member 1	Homo sapiens	182-186
18500934-10	2008	Gene complementation showed that the gene encoding putative DHPS restored the folate biosynthesis pathway and susceptibility to sulfamethoxazole, whereas the mutated sequence was associated with sulfamethoxazole resistance.	Folic Acid	78-84	deoxyhypusine synthase	Homo sapiens	60-64
18551038-3	2008	Response to the antifolate methotrexate (MTX) may be modified in 677TT individuals because MTHFR converts nonmethylated folates, used for thymidine and purine synthesis, to 5-methyltetrahydrofolate, used in homocysteine remethylation to methionine.	Folic Acid	120-127	methylenetetrahydrofolate reductase	Mus musculus	91-96
18468909-4	2008	Since sulfa drugs function as p-aminobenzoic acid mimics and inhibit dihydropteroate synthase (DHPS) in the folate pathway, we hypothesized that sulfa derivatives would act as folate metabolite-mimics and inhibit bacterial folate metabolism.	Folic Acid	108-114	AT695_RS00195	Staphylococcus aureus	69-93
18513846-0	2008	Effect of the methylenetetrahydrofolate reductase gene polymorphisms on homocysteine, folate and vitamin B12 in patients with bipolar disorder and relatives.	Folic Acid	33-39	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	105-108
18565815-16	2008	CONCLUSION: The lower homocysteine, folic acid and B 12 values may be considered as the consequence of an increased cystathionine-beta-synthase activity ("atheroma free model").	Folic Acid	36-46	cystathionine beta-synthase	Homo sapiens	116-143
18468909-4	2008	Since sulfa drugs function as p-aminobenzoic acid mimics and inhibit dihydropteroate synthase (DHPS) in the folate pathway, we hypothesized that sulfa derivatives would act as folate metabolite-mimics and inhibit bacterial folate metabolism.	Folic Acid	108-114	AT695_RS00195	Staphylococcus aureus	95-99
18468909-4	2008	Since sulfa drugs function as p-aminobenzoic acid mimics and inhibit dihydropteroate synthase (DHPS) in the folate pathway, we hypothesized that sulfa derivatives would act as folate metabolite-mimics and inhibit bacterial folate metabolism.	Folic Acid	176-182	AT695_RS00195	Staphylococcus aureus	69-93
18468909-4	2008	Since sulfa drugs function as p-aminobenzoic acid mimics and inhibit dihydropteroate synthase (DHPS) in the folate pathway, we hypothesized that sulfa derivatives would act as folate metabolite-mimics and inhibit bacterial folate metabolism.	Folic Acid	176-182	AT695_RS00195	Staphylococcus aureus	95-99
18468909-4	2008	Since sulfa drugs function as p-aminobenzoic acid mimics and inhibit dihydropteroate synthase (DHPS) in the folate pathway, we hypothesized that sulfa derivatives would act as folate metabolite-mimics and inhibit bacterial folate metabolism.	Folic Acid	176-182	AT695_RS00195	Staphylococcus aureus	69-93
18468909-4	2008	Since sulfa drugs function as p-aminobenzoic acid mimics and inhibit dihydropteroate synthase (DHPS) in the folate pathway, we hypothesized that sulfa derivatives would act as folate metabolite-mimics and inhibit bacterial folate metabolism.	Folic Acid	176-182	AT695_RS00195	Staphylococcus aureus	95-99
18482337-7	2008	In addition, the potency is 70-90 times higher for M.tb DHPS as compared to that for the pterin and folate-binding sites of key human proteins.	Folic Acid	100-106	dihydropteroate synthetase	Escherichia coli	56-60
17522618-0	2008	The folic acid metabolite L-5-methyltetrahydrofolate effectively reduces total serum homocysteine level in orthotopic liver transplant recipients: a double-blind placebo-controlled study.	Folic Acid	4-14	ribosomal protein L5	Homo sapiens	26-29
17522618-9	2008	CONCLUSION: The effects of L-5-MTHF are significantly more potent than folic acid itself.	Folic Acid	71-81	ribosomal protein L5	Homo sapiens	27-35
18709891-3	2008	The spread of folic acid fortification has also introduced concerns about folate"s potentially adverse neurologic consequences in persons with undetected vitamin B12 deficiency.	Folic Acid	14-24	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	162-165
18709892-9	2008	The experience with interventions involving folic acid could provide a model for the subsequent development of supplementation and fortification programs involving vitamin B12.	Folic Acid	44-54	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	172-175
18375715-1	2008	Folic acid (FA) is a member of the B-vitamin family with cardiovascular roles in homocysteine regulation and endothelial nitric oxide synthase (eNOS) activity.	Folic Acid	0-10	nitric oxide synthase 3	Homo sapiens	109-142
18436268-0	2008	Folic acid protects motor neurons against the increased homocysteine, inflammation and apoptosis in SOD1 G93A transgenic mice.	Folic Acid	0-10	superoxide dismutase 1, soluble	Mus musculus	100-104
17597160-8	2008	In patients with PAD or DM, folic acid and B vitamins administration resulted in significant reduction (P &lt; 0.001) of plasma levels of homocysteine (20.9% and 26.2%), VEGF (29.7% and 40.4%) and endostatin (9.4% and 5.7%), respectively.	Folic Acid	28-38	vascular endothelial growth factor A	Homo sapiens	170-174
17597160-9	2008	Moreover, VEGF and endostatin mRNA expression in leukocytes was down-regulated in all patients after B vitamins and folate treatment.	Folic Acid	116-122	vascular endothelial growth factor A	Homo sapiens	10-14
17597160-10	2008	CONCLUSION: These findings demonstrate that lowering of homocysteine with B vitamins and folic acid resulted in substantial reduction of plasma levels of VEGF but minimal reduction of endostatin and in down-regulation of their expression in leukocytes in patients with PAD or DM.	Folic Acid	89-99	vascular endothelial growth factor A	Homo sapiens	154-158
18461199-1	2008	Density functional calculations have been carried out on the experimentally characterized Co(III) [Co(N4)(O2CO)]+ carbonate complexes containing a tripodal tetraamine ligand (N4 = tpa, Metpa, Me2tpa, Me3tpa, pmea, pmap, tepa) and also the model [Co(NH3)4(O2CO)]+ system.	Folic Acid	102-104	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	90-97
18313674-1	2008	OBJECTIVE: To study the effect of folic acid on homocysteine (Hcy) levels in women with insulin resistance and polycystic ovary syndrome (PCOS) in a prospective clinical trial.	Folic Acid	34-44	insulin	Homo sapiens	88-95
18551038-9	2008	MTHFR-Tg mice were generated and confirmed to have increased levels of MTHFR with altered distributions of folate and thiols in a tissue-specific manner.	Folic Acid	107-113	methylenetetrahydrofolate reductase	Mus musculus	0-5
18207340-9	2008	PKC, PTK and Ca2+/calmodulin pathways appeared to play important roles in the regulation of folic acid uptake.	Folic Acid	92-102	EPH receptor A8	Homo sapiens	5-8
18525129-0	2008	Involvement of ApoE E4 and H63D in sporadic Alzheimer"s disease in a folate-supplemented Ontario population.	Folic Acid	69-75	apolipoprotein E	Homo sapiens	15-19
18525129-2	2008	In this pilot study, common variants of the apolipoprotein E (APOE) and HFE genes resulting in the iron overload disorder of hereditary hemochromatosis (C282Y, H63D and S65C) were evaluated as factors in sporadic AD in an Ontario sample in which folic acid fortification has been mandatory since 1998.	Folic Acid	246-256	apolipoprotein E	Homo sapiens	44-60
18525129-2	2008	In this pilot study, common variants of the apolipoprotein E (APOE) and HFE genes resulting in the iron overload disorder of hereditary hemochromatosis (C282Y, H63D and S65C) were evaluated as factors in sporadic AD in an Ontario sample in which folic acid fortification has been mandatory since 1998.	Folic Acid	246-256	apolipoprotein E	Homo sapiens	62-66
17681772-8	2008	A significant increase in p53 exon 7-8 strand breaks was observed with decreasing folate in NCM460 cells.	Folic Acid	82-88	tumor protein p53	Homo sapiens	26-29
17681772-5	2008	With decreasing folate, the expression of both E-cadherin and SMAD-4 was decreased in NCM356.	Folic Acid	16-22	cadherin 1	Homo sapiens	47-57
18234225-1	2008	Human glutamate carboxypeptidase II (GCPII) is involved in neuronal signal transduction and intestinal folate absorption by means of the hydrolysis of its two natural substrates, N-acetyl-aspartyl-glutamate and folyl-poly-gamma-glutamates, respectively.	Folic Acid	103-109	folate hydrolase 1	Homo sapiens	6-35
19099731-22	2008	(4) The DHPR deficient patient must be treated with higher dose of BH4 (8 - 20) mg/(kg.d), neurotransmitter precursors and folic acid as well.	Folic Acid	123-133	quinoid dihydropteridine reductase	Homo sapiens	8-12
18326613-9	2008	However, higher plasma folate concentrations were moderately associated with an increased risk of developing premenopausal breast cancer (P for trend = 0.04) and for developing estrogen receptor (ER)-positive or progesterone receptor (PR)-positive breast tumors (P for trend &lt; or = 0.06).	Folic Acid	23-29	estrogen receptor 1	Homo sapiens	177-194
18326613-9	2008	However, higher plasma folate concentrations were moderately associated with an increased risk of developing premenopausal breast cancer (P for trend = 0.04) and for developing estrogen receptor (ER)-positive or progesterone receptor (PR)-positive breast tumors (P for trend &lt; or = 0.06).	Folic Acid	23-29	estrogen receptor 1	Homo sapiens	196-198
18299144-5	2008	CONCLUSION: In elderly AMI patients the concomitant elevation of CRP and tHcy, associated with folate and vitamin B12 low levels, could be considered a significant predictive heart mortality risk factor.	Folic Acid	95-101	C-reactive protein	Homo sapiens	65-68
18234225-1	2008	Human glutamate carboxypeptidase II (GCPII) is involved in neuronal signal transduction and intestinal folate absorption by means of the hydrolysis of its two natural substrates, N-acetyl-aspartyl-glutamate and folyl-poly-gamma-glutamates, respectively.	Folic Acid	103-109	folate hydrolase 1	Homo sapiens	37-42
18086804-4	2008	BCRP substrates include numerous drugs (topotecan, nitrofurantoin, cimetidine) as well as food carcinogens (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) and the vitamins riboflavin and folic acid.	Folic Acid	189-199	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	0-4
18086128-3	2008	Choroid plexus epithelial cells express high levels of folate receptor alpha (FRalpha) suggesting that the choroid plays an important role in CNS folate trafficking and maintenance of CSF folate levels.	Folic Acid	55-61	rabaptin, RAB GTPase binding effector protein 2	Rattus norvegicus	78-85
18086128-3	2008	Choroid plexus epithelial cells express high levels of folate receptor alpha (FRalpha) suggesting that the choroid plays an important role in CNS folate trafficking and maintenance of CSF folate levels.	Folic Acid	146-152	rabaptin, RAB GTPase binding effector protein 2	Rattus norvegicus	78-85
18086128-6	2008	FRalpha binds 5-MTHF with high affinity and facilitates efficient uptake of 5-MTHF at low extracellular folate concentrations; a lower affinity FRalpha independent system accounts for increased folate uptake at higher concentrations.	Folic Acid	104-110	rabaptin, RAB GTPase binding effector protein 2	Rattus norvegicus	0-7
18086128-6	2008	FRalpha binds 5-MTHF with high affinity and facilitates efficient uptake of 5-MTHF at low extracellular folate concentrations; a lower affinity FRalpha independent system accounts for increased folate uptake at higher concentrations.	Folic Acid	194-200	rabaptin, RAB GTPase binding effector protein 2	Rattus norvegicus	0-7
18086128-6	2008	FRalpha binds 5-MTHF with high affinity and facilitates efficient uptake of 5-MTHF at low extracellular folate concentrations; a lower affinity FRalpha independent system accounts for increased folate uptake at higher concentrations.	Folic Acid	194-200	rabaptin, RAB GTPase binding effector protein 2	Rattus norvegicus	144-151
18086128-10	2008	This is consistent with the role we have proposed for proton-coupled folate transporter in FRalpha-mediated transport as the mechanism of export of folates from the endocytic compartment containing FRalpha.	Folic Acid	148-155	rabaptin, RAB GTPase binding effector protein 2	Rattus norvegicus	91-98
18086128-10	2008	This is consistent with the role we have proposed for proton-coupled folate transporter in FRalpha-mediated transport as the mechanism of export of folates from the endocytic compartment containing FRalpha.	Folic Acid	148-155	rabaptin, RAB GTPase binding effector protein 2	Rattus norvegicus	198-205
18003640-4	2008	In this study, we present a Fkbp8 mouse mutant that has an isolated and completely penetrant spina bifida, which is folate- and inositol-resistant.	Folic Acid	116-122	FK506 binding protein 8	Mus musculus	28-33
18078962-12	2008	Moreover, the pretreatment of mice with WAY100635 (0.1mg/kg, s.c., a selective 5-HT(1A) receptor antagonist) blocked the decrease in immobility time in the FST elicited by folic acid (50mg/kg, p.o.	Folic Acid	172-182	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	79-96
18174236-9	2008	In addition, interaction between the MTRR A66G polymorphism and folate intake for risk of postmenopausal breast cancer was observed (interaction P = 0.008).	Folic Acid	64-70	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	37-41
18078962-17	2008	Overall, the results firstly indicate that folic acid produced an antidepressant-like effect in FST and in TST and that this effect appears to be mediated by an interaction with the serotonergic (5-HT(1A) and 5-HT(2A/2C) receptors) and noradrenergic (alpha(1)- and alpha(2)-adrenoceptors) systems.	Folic Acid	43-53	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	196-203
18709301-9	2008	Folic acid levels correlated inversely with homocysteine and positively with fibrinogen levels.	Folic Acid	0-10	fibrinogen beta chain	Homo sapiens	77-87
18463447-7	2008	The folate gradient R(CSF/S) was negatively correlated with serum folate (p < 0.001, R(2) = 0.518) and to the albumin ratio, a blood-CSF barrier biomarker (beta = -0.235).	Folic Acid	4-10	albumin	Homo sapiens	110-117
18691054-8	2008	In vitro, the MRP/ABCC transporters can collectively confer resistance to natural product anticancer drugs and their conjugated metabolites, platinum compounds, folate antimetabolites, nucleoside and nucleotide analogs, arsenical and antimonial oxyanions, peptide-based agents, and in concert with alterations in phase II conjugating or biosynthetic enzymes, classical alkylating agents, alkylating agents.	Folic Acid	161-167	ATP binding cassette subfamily C member 1	Homo sapiens	14-17
18691054-8	2008	In vitro, the MRP/ABCC transporters can collectively confer resistance to natural product anticancer drugs and their conjugated metabolites, platinum compounds, folate antimetabolites, nucleoside and nucleotide analogs, arsenical and antimonial oxyanions, peptide-based agents, and in concert with alterations in phase II conjugating or biosynthetic enzymes, classical alkylating agents, alkylating agents.	Folic Acid	161-167	ATP binding cassette subfamily C member 1	Homo sapiens	18-22
17851649-10	2008	The offspring of mothers with a combination of high folate and low vitamin B12 concentrations were the most insulin resistant.	Folic Acid	52-58	insulin	Homo sapiens	108-115
17961509-6	2007	These results support an in vivo role for mouse Nat2/human NAT1 in folate metabolism.	Folic Acid	67-73	N-acetyltransferase 2 (arylamine N-acetyltransferase)	Mus musculus	48-52
17311055-6	2008	Especially vitamin E in combination with other vitamins like vitamin C, vitamin B(1), B(2), B(6), B(12), niacin, folic acid, pantothenic acid and selenium, was significantly associated with lower CRP levels.	Folic Acid	113-123	C-reactive protein	Homo sapiens	196-199
19172696-2	2008	In this nested case-referent study, we related two such polymorphisms, reduced folate carrier (RFC1) 80G &gt; A and folate hydrolase 1 (FOLH1) 1561C &gt; T, to the risk of colorectal cancer, taking into account pre-diagnostic plasma folate and total homocysteine concentrations and the MTHFR 677C &gt; T polymorphism, which were analysed in a previous study.	Folic Acid	116-122	folate hydrolase 1	Homo sapiens	136-141
19172696-5	2008	In contrast, the FOLH1 1561T-allele was associated with higher plasma folate and reduced plasma total homocysteine concentrations, and the result was statistically significant only for homocysteine.	Folic Acid	70-76	folate hydrolase 1	Homo sapiens	17-22
19172696-9	2008	CONCLUSIONS: These findings suggest that although the RFC1 80G &gt; A and FOLH1 1561C &gt; T polymorphisms may influence folate status, they are not likely to have a major independent role in the development of colorectal cancer.	Folic Acid	121-127	folate hydrolase 1	Homo sapiens	74-79
18804700-10	2008	The crystal structure of GNMT complexed with 5-CH(3)-THF revealed that there are two folate molecules bound to one tetrameric form of GNMT, which is a basis for establishing of mechanism of inhibition of GNMT.	Folic Acid	85-91	glycine N-methyltransferase	Homo sapiens	25-29
18024309-4	2007	RESULTS: Serum CRP level was comparable between the two groups before the treatment, but significantly reduced after vitamin B6 and folic acid treatment (7.56-/+2.94 mg/L vs 12.23-/+4.16 mg/L, P&lt;0.05).	Folic Acid	132-142	C-reactive protein	Homo sapiens	15-18
18024309-5	2007	Additional vitamin B6 and folic acid treatment significantly lowered plasma HCA level (4.56-/+1.14 micromol/L vs 7.79-/+1.79 micromol/L, P&lt;0.05), and correlation analysis demonstrated a positive correlation between plasma HCA and serum CRP levels (r=0.697, P&lt;0.01).	Folic Acid	26-36	C-reactive protein	Homo sapiens	239-242
17553737-1	2007	Ten novel macrocyclic Co(II) compounds have been synthesized by treating four N(4) and six N(2)O(2) donor macrocycles with cobalt chloride in methanol.	Folic Acid	78-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-28
17892308-12	2007	The biological implications of an attenuated mechanism of MS reactivation by MSR on methionine and folate metabolism are discussed.	Folic Acid	99-105	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	77-80
18408370-0	2008	Ineffectiveness of folic acid supplementation against phenytoin-induced decrease in salivary immunoglobulin A concentration of epileptic patients.	Folic Acid	19-29	CD79a molecule	Homo sapiens	93-109
18408370-1	2008	AIMS: This study was designed to investigate if folate treatment is able to reverse the phenytoin-induced deficiency of salivary immunoglobulin A (IgA).	Folic Acid	48-54	CD79a molecule	Homo sapiens	147-150
18408370-3	2008	The salivary IgA concentration of these patients was measured before and after 2 months of folic acid administration and compared with those of 10 healthy individuals.	Folic Acid	91-101	CD79a molecule	Homo sapiens	13-16
18408370-5	2008	RESULTS: Salivary IgA levels of patients receiving phenytoin (11.7 +/- 4.8 IU/l) were significantly (p = 0.039) lower than those of healthy controls (14.8 +/- 3.2 IU/l), but did not statistically (p = 0.541) differ from levels (11.8 +/- 4.6 IU/l) measured after 2 months of folic acid supplementation.	Folic Acid	274-284	CD79a molecule	Homo sapiens	18-21
18569587-10	2008	After implementation of the SNP into the model significant lower adjusted means of urinary PGA concentrations were found for GSTP1 105IleVal and CYP2E1 -71TT.	Folic Acid	91-94	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	145-151
18716414-0	2008	Effect of folic acid combined with fluoxetine in patients with major depression on plasma homocysteine and vitamin B12, and serotonin levels in lymphocytes.	Folic Acid	10-20	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	115-118
20641248-3	2004	It is believed that PSMA plays an important role in the progression of prostate cancer, glutamatergic neurotransmission, and in the absorption of folate (2).	Folic Acid	146-152	folate hydrolase 1	Homo sapiens	20-24
17720888-0	2007	Increased expression of Grainyhead-like-3 rescues spina bifida in a folate-resistant mouse model.	Folic Acid	68-74	grainyhead like transcription factor 3	Mus musculus	24-41
17961276-7	2007	It is argued that consuming additional folic acid (as "synthetic" pteroylglutamic acid) from fortified foods increases the risk of "masking" megaloblastic anaemia caused by vitamin B12 deficiency.	Folic Acid	39-49	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	181-184
17961276-7	2007	It is argued that consuming additional folic acid (as "synthetic" pteroylglutamic acid) from fortified foods increases the risk of "masking" megaloblastic anaemia caused by vitamin B12 deficiency.	Folic Acid	66-86	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	181-184
17961276-11	2007	Is the level of intake of folic acid among the elderly (post-fortification) likely to be so high as to cure or "mask" the anaemia associated with vitamin B12 deficiency?	Folic Acid	26-36	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	154-157
17921385-0	2007	Methylation of estrogen receptor alpha and mutL homolog 1 in normal colonic mucosa: association with folate and vitamin B-12 status in subjects with and without colorectal neoplasia.	Folic Acid	101-107	estrogen receptor 1	Homo sapiens	15-38
17921385-2	2007	OBJECTIVE: We tested the hypothesis that biomarkers of folate and vitamin B-12 status are associated with estrogen receptor alpha (ERalpha) and mutL homolog 1 (MLH1) promoter methylation in subjects with and without neoplasia.	Folic Acid	55-61	estrogen receptor 1	Homo sapiens	106-129
17921385-2	2007	OBJECTIVE: We tested the hypothesis that biomarkers of folate and vitamin B-12 status are associated with estrogen receptor alpha (ERalpha) and mutL homolog 1 (MLH1) promoter methylation in subjects with and without neoplasia.	Folic Acid	55-61	estrogen receptor 1	Homo sapiens	131-138
17764386-3	2007	When clinically relevant concentrations of Hcy and folate were added to the cultured monocytes for 4 days, we found that clinically relevant Hcy (100 microM) may increase the levels of total cholesterol (TC), free cholesterol (FC), and cholesteryl ester (CE), and also decrease ApoE mRNA, protein expressions, leading to 34.28%, 45.00% in cultured primary human monocytes in comparison to the positive group.	Folic Acid	51-57	apolipoprotein E	Homo sapiens	278-282
17764386-5	2007	However, folate decreased the levels of TC, FC, and CE (p &lt; 0.001) and increased the ApoE expression; as to say, folate primarily repressed the effects of DNA methylation induced by Hcy and reduced anti atherosclerosis.	Folic Acid	9-15	apolipoprotein E	Homo sapiens	88-92
17586472-0	2007	Targeted delivery of catalase and superoxide dismutase to macrophages using folate.	Folic Acid	76-82	catalase	Homo sapiens	21-29
17972439-0	2007	If high folic acid aggravates vitamin B12 deficiency what should be done about it?	Folic Acid	8-18	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	38-41
17972439-3	2007	There is concern that high intakes of folic acid from fortified food and dietary supplements might mask the macrocytic anemia of vitamin B12 deficiency, thereby eliminating an important diagnostic sign.	Folic Acid	38-48	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	137-140
17972439-4	2007	One recent study indicates that high serum folate levels during vitamin B12 deficiency exacerbate (rather than mask) anemia and worsen cognitive symptoms.	Folic Acid	43-49	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	72-75
17972439-6	2007	Together, these studies provide further evidence that public health strategies are needed to improve vitamin B12 status in order to decrease the risk of deficiency and any potentially adverse interactions with folic acid.	Folic Acid	210-220	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	109-112
17875718-1	2007	Folylpolyglutamate synthase (FPGS) catalyzes the polyglutamation of folic acid, methotrexate, and pemetrexed to produce highly active metabolites.	Folic Acid	68-78	folylpolyglutamate synthase, mitochondrial	Cricetulus griseus	0-27
17875718-1	2007	Folylpolyglutamate synthase (FPGS) catalyzes the polyglutamation of folic acid, methotrexate, and pemetrexed to produce highly active metabolites.	Folic Acid	68-78	folylpolyglutamate synthase, mitochondrial	Cricetulus griseus	29-33
17984565-0	2007	[Efficacy and safety of heptral, vitamin B6 and folic acid during toxic hepatitis induced by CCL4].	Folic Acid	48-58	C-C motif chemokine ligand 4	Rattus norvegicus	93-97
17586472-0	2007	Targeted delivery of catalase and superoxide dismutase to macrophages using folate.	Folic Acid	76-82	superoxide dismutase 1	Homo sapiens	34-54
17586472-5	2007	Folate was conjugated to CAT and SOD using NHS/EDC chemistry with high efficiency.	Folic Acid	0-6	catalase	Homo sapiens	25-28
17586472-5	2007	Folate was conjugated to CAT and SOD using NHS/EDC chemistry with high efficiency.	Folic Acid	0-6	superoxide dismutase 1	Homo sapiens	33-36
17586472-7	2007	We anticipate numerous applications of folate-conjugated CAT and SOD in treating inflammatory diseases, based on their efficacy and straightforward synthesis.	Folic Acid	39-45	catalase	Homo sapiens	57-60
17586472-7	2007	We anticipate numerous applications of folate-conjugated CAT and SOD in treating inflammatory diseases, based on their efficacy and straightforward synthesis.	Folic Acid	39-45	superoxide dismutase 1	Homo sapiens	65-68
17605895-0	2007	Effects of folic acid and vitamin B complex on serum C-reactive protein and albumin levels in stable hemodialysis patients.	Folic Acid	11-21	C-reactive protein	Homo sapiens	53-71
17475669-1	2007	Two putative orthologs to the human reduced folate carrier (hRFC), folt-1 and folt-2, which share a 40 and 31% identity, respectively, with the hRFC sequence, have been identified in the Caenorhabditis elegans genome.	Folic Acid	44-50	Folate transporter 1	Caenorhabditis elegans	67-73
17475669-3	2007	Transport of folate by folt-1 expressed in a heterologous expression system showed an acidic pH dependence, saturability (apparent K(m) of 1.23 +/- 0.18 microM), a similar degree of inhibition by reduced and substituted folate derivatives, sensitivity to the anti-inflammatory drug sulfasalazine (apparent K(i) of 0.13 mM), and inhibition by anion transport inhibitors, e.g., DIDS.	Folic Acid	13-19	Folate transporter 1	Caenorhabditis elegans	23-29
17475669-3	2007	Transport of folate by folt-1 expressed in a heterologous expression system showed an acidic pH dependence, saturability (apparent K(m) of 1.23 +/- 0.18 microM), a similar degree of inhibition by reduced and substituted folate derivatives, sensitivity to the anti-inflammatory drug sulfasalazine (apparent K(i) of 0.13 mM), and inhibition by anion transport inhibitors, e.g., DIDS.	Folic Acid	220-226	Folate transporter 1	Caenorhabditis elegans	23-29
17475669-4	2007	Knocking down (silencing) or knocking out the folt-1 gene led to a significant inhibition of folate uptake by intact living C. elegans.	Folic Acid	93-99	Folate transporter 1	Caenorhabditis elegans	46-52
17684227-0	2007	Relations of glutamate carboxypeptidase II (GCPII) polymorphisms to folate and homocysteine concentrations and to scores of cognition, anxiety, and depression in a homogeneous Norwegian population: the Hordaland Homocysteine Study.	Folic Acid	68-74	folate hydrolase 1	Homo sapiens	13-42
17684227-0	2007	Relations of glutamate carboxypeptidase II (GCPII) polymorphisms to folate and homocysteine concentrations and to scores of cognition, anxiety, and depression in a homogeneous Norwegian population: the Hordaland Homocysteine Study.	Folic Acid	68-74	folate hydrolase 1	Homo sapiens	44-49
17684227-2	2007	Previous studies provided conflicting results on the effect of the GCPII 1561C--&gt;T polymorphism on folate and total homocysteine (tHcy) concentrations.	Folic Acid	102-108	folate hydrolase 1	Homo sapiens	67-72
17684227-3	2007	OBJECTIVE: We aimed to determine the potential effects of 2 polymorphisms of GCPII on plasma folate and tHcy concentrations, cognition, anxiety, and depression in a large aging cohort of Norwegians enrolled in the Hordaland Homocysteine Study.	Folic Acid	93-99	folate hydrolase 1	Homo sapiens	77-82
17605895-9	2007	CONCLUSIONS: Folic acid and vitamin B complex co-administration effectively lowers tHcy and hs-CRP levels and increases albumin levels in stable hemodialysis subjects, underscoring their potential benefit to attenuate the state of inflammation and possibly improve the nutritional status in patients on hemodialysis.	Folic Acid	13-23	albumin	Homo sapiens	120-127
17611986-1	2007	OBJECTIVE: To investigate the distribution of the A2756G polymorphism of the methionine synthase reductase (MTR) gene in patients with rheumatoid arthritis (RA) treated with methotrexate (MTX) compared with a healthy control group; and to examine the relationships among the A2756G polymorphism, plasma total homocysteine (tHcy), serum folate and vitamin B12 levels, disease activity, and MTX toxicity in patients with RA.	Folic Acid	336-342	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	77-106
17611986-1	2007	OBJECTIVE: To investigate the distribution of the A2756G polymorphism of the methionine synthase reductase (MTR) gene in patients with rheumatoid arthritis (RA) treated with methotrexate (MTX) compared with a healthy control group; and to examine the relationships among the A2756G polymorphism, plasma total homocysteine (tHcy), serum folate and vitamin B12 levels, disease activity, and MTX toxicity in patients with RA.	Folic Acid	336-342	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	108-111
17545639-11	2007	Among participants who obtain these factors exclusively through dietary sources, there may be an inverse relation between circulating folate, B6, and B12 and risk.	Folic Acid	134-140	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	150-153
17320366-9	2007	The response of the DKK1 and TAGLN gene promoters to folate deficiency and compounds was examined in NIH3T3 cells using luciferase reporter plasmids.	Folic Acid	53-59	dickkopf WNT signaling pathway inhibitor 1	Mus musculus	20-24
17698004-2	2007	We determined that the product of the orf17 gene of Escherichia coli, a Nudix NTP hydrolase, catalyzes the hydrolytic release of pyrophosphate from dihydroneopterin triphosphate, the committed step of folate synthesis in bacteria.	Folic Acid	201-207	putative transposase	Escherichia coli	38-43
17577393-7	2007	CONCLUSIONS: Ethanol feeding with a folate-deficient diet stimulates hepatic lipid synthesis by down-regulating adiponectin-mediated pathways of p-AMPK to increase the expression of nSREBP-1c and its targeted lipogenic enzymes.	Folic Acid	36-42	adiponectin, C1Q and collagen domain containing	Homo sapiens	112-123
17585020-0	2007	Older age and dietary folate are determinants of genomic and p16-specific DNA methylation in mouse colon.	Folic Acid	22-28	cytochrome P450, family 2, subfamily b, polypeptide 10	Mus musculus	61-64
17585020-7	2007	In old mice, genomic and p16 promoter DNA methylation each increased in a manner that was directly related to dietary folate (P(trend) = 0.009).	Folic Acid	118-124	cytochrome P450, family 2, subfamily b, polypeptide 10	Mus musculus	25-28
17585020-8	2007	Age-related enhancement of p16 expression occurred in folate-replete (P = 0.001) and folate-supplemented groups (P = 0.041), but not in the folate-deplete group.	Folic Acid	54-60	cytochrome P450, family 2, subfamily b, polypeptide 10	Mus musculus	27-30
17585020-8	2007	Age-related enhancement of p16 expression occurred in folate-replete (P = 0.001) and folate-supplemented groups (P = 0.041), but not in the folate-deplete group.	Folic Acid	85-91	cytochrome P450, family 2, subfamily b, polypeptide 10	Mus musculus	27-30
17585020-8	2007	Age-related enhancement of p16 expression occurred in folate-replete (P = 0.001) and folate-supplemented groups (P = 0.041), but not in the folate-deplete group.	Folic Acid	85-91	cytochrome P450, family 2, subfamily b, polypeptide 10	Mus musculus	27-30
17289311-4	2007	There was an increased level of uptake of folate-conjugated micellar PTX (i.e. FOL-P105/PTX, FOL-PL/PTX) compared to plain micellar PTX (i.e. P105/PTX, PL/PTX) in human breast cancer MDR cell sublines, MCF-7/ADR, and the uptake of folate-conjugated micellar PTX could be inhibited by free folic acid, which suggested that the level of uptake could be mediated by the folate receptor.	Folic Acid	42-48	nuclear factor kappa B subunit 1	Homo sapiens	83-91
17289311-4	2007	There was an increased level of uptake of folate-conjugated micellar PTX (i.e. FOL-P105/PTX, FOL-PL/PTX) compared to plain micellar PTX (i.e. P105/PTX, PL/PTX) in human breast cancer MDR cell sublines, MCF-7/ADR, and the uptake of folate-conjugated micellar PTX could be inhibited by free folic acid, which suggested that the level of uptake could be mediated by the folate receptor.	Folic Acid	42-48	nuclear factor kappa B subunit 1	Homo sapiens	142-150
17604457-7	2007	Folic acid administration has also been shown to alleviate the symptoms of RLS and may play a role in the treatment of primary (familial) RLS.	Folic Acid	0-10	RLS1	Homo sapiens	75-78
17604457-7	2007	Folic acid administration has also been shown to alleviate the symptoms of RLS and may play a role in the treatment of primary (familial) RLS.	Folic Acid	0-10	RLS1	Homo sapiens	138-141
17629209-6	2007	There was a significant increase of patients with NSCL/P in pregnant women exposed to infection, drug intake and folic acid deficiency.	Folic Acid	113-123	nescient helix-loop-helix 1	Homo sapiens	50-54
17629209-9	2007	Infection, drug intake and folic acid supplement during pregnancy were associated with the occurrence of NSCL/P.	Folic Acid	27-37	nescient helix-loop-helix 1	Homo sapiens	105-109
17605895-0	2007	Effects of folic acid and vitamin B complex on serum C-reactive protein and albumin levels in stable hemodialysis patients.	Folic Acid	11-21	albumin	Homo sapiens	76-83
16963246-3	2007	Apc(min/+) mice with heterozygous knockout of the gene for reduced folate carrier 1 (Rfc1(+/-)) developed significantly fewer adenomas compared to Rfc1(+/+)Apc(min/+) mice [30.3+/-4.6 vs. 60.4+/-9.4 on a control diet (CD) and 42.6+/-4.4 vs. 55.8+/-7.6 on a folate-deficient diet, respectively].	Folic Acid	67-73	replication factor C (activator 1) 1	Mus musculus	85-89
17420345-7	2007	Low-dose folic acid increased nitric oxide-mediated endothelium-dependent vasomotor responses, reduced vascular superoxide production, and improved enzymatic coupling of endothelial nitric oxide synthase through availability of the cofactor tetrahydrobiopterin.	Folic Acid	9-19	nitric oxide synthase 3	Homo sapiens	170-203
17420345-10	2007	CONCLUSIONS: Low-dose folic acid treatment, comparable to daily intake and dietary fortification, improves vascular function through effects on endothelial nitric oxide synthase and vascular oxidative stress.	Folic Acid	22-32	nitric oxide synthase 3	Homo sapiens	144-177
17438114-2	2007	The methylenetetrahydrofolate dehydrogenase (MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway.	Folic Acid	23-29	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	45-50
17438114-2	2007	The methylenetetrahydrofolate dehydrogenase (MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway.	Folic Acid	23-29	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	137-142
17438114-2	2007	The methylenetetrahydrofolate dehydrogenase (MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway.	Folic Acid	79-85	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	4-43
17438114-2	2007	The methylenetetrahydrofolate dehydrogenase (MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway.	Folic Acid	79-85	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	45-50
17438114-2	2007	The methylenetetrahydrofolate dehydrogenase (MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway.	Folic Acid	79-85	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	137-142
17438114-8	2007	CONCLUSIONS: The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis.	Folic Acid	208-214	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	45-50
17448316-0	2007	[Folic acid antagonist methotrexate causes the development malformation of heart and down-regulates the BMP2b and HAS2 expressions in zebrafish].	Folic Acid	1-11	bone morphogenetic protein 2b	Danio rerio	104-109
17277043-15	2007	Low folate intake in association with CT + TT genotypes (C677T) has significant protective effect on GSTM1 methylation.	Folic Acid	4-10	glutathione S-transferase mu 1	Homo sapiens	101-106
17465256-4	2007	RESULTS: Patients with methylation in p16(INK4a) consumed significantly less folate (p = 0.01), vitamin A (p = 0.01), vitamin B1 (p = 0.007), potassium (p = 0.03) and iron (p = 0.02) than controls.	Folic Acid	77-83	cyclin dependent kinase inhibitor 2A	Homo sapiens	38-41
17465256-4	2007	RESULTS: Patients with methylation in p16(INK4a) consumed significantly less folate (p = 0.01), vitamin A (p = 0.01), vitamin B1 (p = 0.007), potassium (p = 0.03) and iron (p = 0.02) than controls.	Folic Acid	77-83	cyclin dependent kinase inhibitor 2A	Homo sapiens	42-47
17333344-13	2007	Moreover, down-regulation of MRPs and/or BCRP results in decreased folate efflux thereby leading to expansion of the intracellular folate pool and antifolate resistance.	Folic Acid	67-73	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	41-45
17333344-13	2007	Moreover, down-regulation of MRPs and/or BCRP results in decreased folate efflux thereby leading to expansion of the intracellular folate pool and antifolate resistance.	Folic Acid	131-137	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	41-45
17118406-0	2007	Folic acid supplementation delays atherosclerotic lesion development in apoE-deficient mice.	Folic Acid	0-10	apolipoprotein E	Mus musculus	72-76
17134675-1	2007	The enzymes 6-hydroxymethylpterin pyrophosphokinase (HPPK) and dihydropteroate synthase (DHPS) catalyze sequential steps in folate biosynthesis.	Folic Acid	124-130	deoxyhypusine synthase	Homo sapiens	63-87
17134675-1	2007	The enzymes 6-hydroxymethylpterin pyrophosphokinase (HPPK) and dihydropteroate synthase (DHPS) catalyze sequential steps in folate biosynthesis.	Folic Acid	124-130	deoxyhypusine synthase	Homo sapiens	89-93
17113603-3	2007	Methionine synthase reductase (MTRR) is an enzyme that catalyzes the remethylation of homocysteine (Hcy) to methionine via cobalamin and folate dependant reactions.	Folic Acid	137-143	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	0-29
17113603-3	2007	Methionine synthase reductase (MTRR) is an enzyme that catalyzes the remethylation of homocysteine (Hcy) to methionine via cobalamin and folate dependant reactions.	Folic Acid	137-143	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	31-35
17098465-9	2007	In primary human lymphocytes, folate depletion induces a marked increase in p53 exons 5-8 breaks, but does not reduce steady-state levels of p53 mRNA, protein, or impair downstream signaling.	Folic Acid	30-36	tumor protein p53	Homo sapiens	76-79
17098465-10	2007	The induction of p53 strand breaks by folate depletion does not impair p53 expression or action within all human cell lines.	Folic Acid	38-44	tumor protein p53	Homo sapiens	17-20
17111379-6	2007	These data provide the first evidence for localized differences in folate metabolism within the early neural tube and suggest that folate might modulate proliferation via effects on midline Aldh1l1(+) cells.	Folic Acid	131-137	aldehyde dehydrogenase 1 family member L1	Homo sapiens	190-197
17691219-6	2007	The results indicate that of the enzymes studied only polymorphisms of folate-dependent enzyme MTHFD1 have pointed to significant differences in intensity of turnover of circulating thiols between AD and PD patients.	Folic Acid	71-77	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	95-101
17210813-8	2007	The highest quartile of total folate intake was related to a lower risk of AD (hazard ratio, 0.5; 95% confidence interval, 0.3-0.9; P=.02 for trend) after adjustment for age, sex, education, ethnic group, the epsilon4 allele of apolipoprotein E, diabetes mellitus, hypertension, current smoking, heart disease, stroke, and vitamin B6 and B12 levels.	Folic Acid	30-36	apolipoprotein E	Homo sapiens	228-244
16919384-1	2007	2-Phosphoglycolate (PGA), a strong competitive inhibitor of the dimeric enzyme triosephosphate isomerase (TIM), brings about a large decrease in the unfolding rate constant of the protein.	Folic Acid	20-23	triosephosphate isomerase 1	Homo sapiens	79-104
16919384-1	2007	2-Phosphoglycolate (PGA), a strong competitive inhibitor of the dimeric enzyme triosephosphate isomerase (TIM), brings about a large decrease in the unfolding rate constant of the protein.	Folic Acid	20-23	triosephosphate isomerase 1	Homo sapiens	106-109
16919384-3	2007	However, if the thermodynamics for binding of PGA to native TIM is taken into account, it becomes clear that a dimeric TS is the right assumption.	Folic Acid	46-49	triosephosphate isomerase 1	Homo sapiens	60-63
17279620-8	2007	This model suggests that the MFT R249A and G192E mutations both modify the base of a basket-shaped structure that appears to constitute a trap door for the flux of folates into the mitochondrial matrix.	Folic Acid	164-171	solute carrier family 25 member 32	Homo sapiens	29-32
17357445-9	2007	The addition of folic acid (100 micromol/L)resulted in partial antagonistic effects against the injury of Hcy on NOS system of endothelial cells, the eNOS protein level and eNOS activity, and NO production increased,and so does the DDAH activity,and the ADMA concentration reduced.	Folic Acid	16-26	nitric oxide synthase 3	Homo sapiens	150-154
17357445-9	2007	The addition of folic acid (100 micromol/L)resulted in partial antagonistic effects against the injury of Hcy on NOS system of endothelial cells, the eNOS protein level and eNOS activity, and NO production increased,and so does the DDAH activity,and the ADMA concentration reduced.	Folic Acid	16-26	nitric oxide synthase 3	Homo sapiens	173-177
17357445-9	2007	The addition of folic acid (100 micromol/L)resulted in partial antagonistic effects against the injury of Hcy on NOS system of endothelial cells, the eNOS protein level and eNOS activity, and NO production increased,and so does the DDAH activity,and the ADMA concentration reduced.	Folic Acid	16-26	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	232-236
17357445-13	2007	Folic acid can exert partial protective roles against the Hcy in the level of eNOS protein and eNOS activity,but without impact on the expression of eNOS gene.	Folic Acid	0-10	nitric oxide synthase 3	Homo sapiens	78-82
17357445-13	2007	Folic acid can exert partial protective roles against the Hcy in the level of eNOS protein and eNOS activity,but without impact on the expression of eNOS gene.	Folic Acid	0-10	nitric oxide synthase 3	Homo sapiens	95-99
17357445-13	2007	Folic acid can exert partial protective roles against the Hcy in the level of eNOS protein and eNOS activity,but without impact on the expression of eNOS gene.	Folic Acid	0-10	nitric oxide synthase 3	Homo sapiens	95-99
17237316-0	2007	Intake of fish oil, oleic acid, folic acid, and vitamins B-6 and E for 1 year decreases plasma C-reactive protein and reduces coronary heart disease risk factors in male patients in a cardiac rehabilitation program.	Folic Acid	32-42	C-reactive protein	Homo sapiens	95-113
17425871-8	2007	CONCLUSION: Methylcobalamin and folic acid treatment alone can decrease the Hcy level and increase the HTase/PON activity in the patients with type 2 diabetes mellitus, and the methylcobalamin and folic acid combination therapy is much more effective.	Folic Acid	32-42	paraoxonase 1	Homo sapiens	109-112
17425871-9	2007	Folic acid may affect the HTase/PON activity through its antioxidant ability.	Folic Acid	0-10	paraoxonase 1	Homo sapiens	32-35
17098465-0	2007	Folate depletion in human lymphocytes up-regulates p53 expression despite marked induction of strand breaks in exons 5-8 of the gene.	Folic Acid	0-6	tumor protein p53	Homo sapiens	51-54
17098465-5	2007	Cells grown in 15 nM folate developed significant levels of p53 strand breaks, reflected by reductions in amplifiable DNA from p53 exons 5-8 (approximately 40% loss, P&lt;0.0001) and exons 7-8 (approximately 26% loss, P&lt;0.0001) compared to 30 and 120 nM.	Folic Acid	21-27	tumor protein p53	Homo sapiens	60-63
17098465-5	2007	Cells grown in 15 nM folate developed significant levels of p53 strand breaks, reflected by reductions in amplifiable DNA from p53 exons 5-8 (approximately 40% loss, P&lt;0.0001) and exons 7-8 (approximately 26% loss, P&lt;0.0001) compared to 30 and 120 nM.	Folic Acid	21-27	tumor protein p53	Homo sapiens	127-130
17098465-7	2007	p53 protein abundance increased with decreasing media folate, as did p21 transcript.	Folic Acid	54-60	tumor protein p53	Homo sapiens	0-3
17448316-11	2007	CONCLUSIONS: The inhibition of folic acid function may affect cardiac development of early embryos, resulting in a retardant development and a morphological abnormality of the heart in zebrafish, possibly by down-regulating the expressions of BMP2b and HAS2.	Folic Acid	31-41	bone morphogenetic protein 2b	Danio rerio	243-248
17183144-6	2006	Herein, we demonstrate that dietary deficiency in folate and vitamin E increased PS-1 expression in juvenile and adult normal C57B1/6J and ApoE-/- mice and in aged normal mice.	Folic Acid	50-56	apolipoprotein E	Mus musculus	139-143
17683969-7	2007	Here, we observed that epigallocatechin-3-gallate altered the p16 methylation pattern from methylated to unmethylated as a result of folic acid deprivation.	Folic Acid	133-143	cyclin dependent kinase inhibitor 2A	Homo sapiens	62-65
16917939-10	2006	Differences in allele frequency and/or significant gene-gene interactions were found for relevant genes encoding the reduced folate carrier (RFC 80G &gt; A), transcobalamin II (TCN2 776G &gt; C), catechol-O-methyltransferase (COMT 472G &gt; A), methylenetetrahydrofolate reductase (MTHFR 677C &gt; T and 1298A &gt; C), and glutathione-S-transferase (GST M1).	Folic Acid	125-131	glutathione S-transferase mu 1	Homo sapiens	350-357
16835399-4	2006	The activities of GNMT, phosphatidylethanolamine N-methyltransferase (PEMT), and betaine-homocysteine S-methyltransferase (BHMT) were increased about twofold in diabetic rat liver; folate deficiency resulted in the greatest elevation in GNMT activity.	Folic Acid	181-187	betaine-homocysteine S-methyltransferase	Rattus norvegicus	81-121
16835399-4	2006	The activities of GNMT, phosphatidylethanolamine N-methyltransferase (PEMT), and betaine-homocysteine S-methyltransferase (BHMT) were increased about twofold in diabetic rat liver; folate deficiency resulted in the greatest elevation in GNMT activity.	Folic Acid	181-187	betaine-homocysteine S-methyltransferase	Rattus norvegicus	123-127
16595132-0	2006	Blocking tumor necrosis factor-alpha inhibits folic acid-induced acute renal failure.	Folic Acid	46-56	tumor necrosis factor	Mus musculus	9-36
17032644-5	2006	MTHFR was not inhibited by S-adenosylmethionine and, uniquely among folate-metabolizing enzymes, showed dual-cofactor specificity with NADH and NADPH under physiological conditions.	Folic Acid	68-74	methylenetetrahydrofolate reductase	Mus musculus	0-5
17032644-6	2006	MTHFR null mutants (mthfr(-)) lacked 5-methyltetrahydrofolate, the most abundant intracellular folate, and could not utilize exogenous homocysteine for growth.	Folic Acid	55-61	methylenetetrahydrofolate reductase	Mus musculus	0-5
17032644-6	2006	MTHFR null mutants (mthfr(-)) lacked 5-methyltetrahydrofolate, the most abundant intracellular folate, and could not utilize exogenous homocysteine for growth.	Folic Acid	55-61	methylenetetrahydrofolate reductase	Mus musculus	20-25
16861746-1	2006	BACKGROUND: Three typical folate metabolism enzymes-i.e. methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MS) and MS reductase (MTRR) in the folate cycle-play a critical role in DNA synthesis and methylation reactions.	Folic Acid	26-32	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	145-149
16767497-10	2006	Folate contribution of intestinal bacteria was found to influence p53 protein levels.	Folic Acid	0-6	tumor protein p53	Homo sapiens	66-69
17183426-2	2006	Apolipoprotein E-deficient mice undergo oxidative damage and cognitive impairment when deprived of folate.	Folic Acid	99-105	apolipoprotein E	Mus musculus	0-16
17079455-3	2006	We have developed a new spontaneous tumor model in which mice, with or without a null allele in a key folate-metabolizing enzyme, methylenetetrahydrofolate reductase (Mthfr), develop intestinal tumors due to low dietary folate alone.	Folic Acid	102-108	methylenetetrahydrofolate reductase	Mus musculus	130-165
17079455-3	2006	We have developed a new spontaneous tumor model in which mice, with or without a null allele in a key folate-metabolizing enzyme, methylenetetrahydrofolate reductase (Mthfr), develop intestinal tumors due to low dietary folate alone.	Folic Acid	102-108	methylenetetrahydrofolate reductase	Mus musculus	167-172
17079455-3	2006	We have developed a new spontaneous tumor model in which mice, with or without a null allele in a key folate-metabolizing enzyme, methylenetetrahydrofolate reductase (Mthfr), develop intestinal tumors due to low dietary folate alone.	Folic Acid	149-155	methylenetetrahydrofolate reductase	Mus musculus	167-172
17079455-4	2006	On folate-deficient diets, 12.5% of Mthfr(+/+) mice and 28.1% of Mthfr(+/-) mice developed tumors; mice on control diets were negative.	Folic Acid	3-9	methylenetetrahydrofolate reductase	Mus musculus	36-41
17056795-0	2006	Global DNA and p53 region-specific hypomethylation in human colonic cells is induced by folate depletion and reversed by folate supplementation.	Folic Acid	88-94	tumor protein p53	Homo sapiens	15-18
17056795-0	2006	Global DNA and p53 region-specific hypomethylation in human colonic cells is induced by folate depletion and reversed by folate supplementation.	Folic Acid	121-127	tumor protein p53	Homo sapiens	15-18
17056795-8	2006	These results confirm that decreased folate levels are capable of inducing DNA hypomethylation in colon cells and particularly in the region of the p53 gene, suggesting that a more optimal folate status in vivo may normalize any DNA hypomethylation, offering potential protective effects against carcinogenesis.	Folic Acid	37-43	tumor protein p53	Homo sapiens	148-151
17056795-8	2006	These results confirm that decreased folate levels are capable of inducing DNA hypomethylation in colon cells and particularly in the region of the p53 gene, suggesting that a more optimal folate status in vivo may normalize any DNA hypomethylation, offering potential protective effects against carcinogenesis.	Folic Acid	189-195	tumor protein p53	Homo sapiens	148-151
16832597-0	2006	Folic acid rivals methylenetetrahydrofolate reductase (MTHFR) gene-silencing effect on MEPM cell proliferation and apoptosis.	Folic Acid	0-10	methylenetetrahydrofolate reductase	Mus musculus	18-53
16832597-3	2006	Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene reduce availability of 5-methylenetetrahydrofolate, the predominant circulating form of folic acid.	Folic Acid	158-168	methylenetetrahydrofolate reductase	Mus musculus	21-56
16832597-3	2006	Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene reduce availability of 5-methylenetetrahydrofolate, the predominant circulating form of folic acid.	Folic Acid	158-168	methylenetetrahydrofolate reductase	Mus musculus	58-63
16832597-6	2006	Supplement with 20 microg/ml folic acid was the best to preventing teratogenic effect of MTHFR gene silencing.	Folic Acid	29-39	methylenetetrahydrofolate reductase	Mus musculus	89-94
16504991-9	2006	In patients who were positive for MRP1 at baseline (61%), treatment with MTX and folic acid led to a marked down regulation of MRP1 expression at 6 months.	Folic Acid	81-91	ATP binding cassette subfamily B member 1	Homo sapiens	34-38
16504991-9	2006	In patients who were positive for MRP1 at baseline (61%), treatment with MTX and folic acid led to a marked down regulation of MRP1 expression at 6 months.	Folic Acid	81-91	ATP binding cassette subfamily B member 1	Homo sapiens	127-131
16504991-10	2006	CONCLUSION: In patients with rheumatoid arthritis expressing MRP1, treatment with MTX and folic acid led to down regulation of MRP1 expression.	Folic Acid	90-100	ATP binding cassette subfamily B member 1	Homo sapiens	61-65
16504991-10	2006	CONCLUSION: In patients with rheumatoid arthritis expressing MRP1, treatment with MTX and folic acid led to down regulation of MRP1 expression.	Folic Acid	90-100	ATP binding cassette subfamily B member 1	Homo sapiens	127-131
17061059-13	2006	Until the relationships between menopause, HRT, homocysteine, folate and vitamin B12 are clearly elucidated with more comprehensive studies, including all the details leading to plasma homocysteine increment in homocysteine metabolism, we recommend that menopausal women should be provided with accurate information and risk/benefit analysis on HRT treatment and the decision should be made by the patient.	Folic Acid	62-68	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	81-84
16646054-0	2006	Dietary folate is associated with p16(INK4A) methylation in head and neck squamous cell carcinoma.	Folic Acid	8-14	cyclin dependent kinase inhibitor 2A	Homo sapiens	34-37
16646054-0	2006	Dietary folate is associated with p16(INK4A) methylation in head and neck squamous cell carcinoma.	Folic Acid	8-14	cyclin dependent kinase inhibitor 2A	Homo sapiens	38-43
16646054-3	2006	Decreased dietary folate in an animal model of hepatocellular carcinoma has been associated with the induction of epigenetic silencing of the p16(INK4A) gene.	Folic Acid	18-24	cyclin dependent kinase inhibitor 2A	Homo sapiens	142-145
16646054-3	2006	Decreased dietary folate in an animal model of hepatocellular carcinoma has been associated with the induction of epigenetic silencing of the p16(INK4A) gene.	Folic Acid	18-24	cyclin dependent kinase inhibitor 2A	Homo sapiens	146-151
16646054-4	2006	In an ongoing population-based study of HNSCC, we sought to extend this observation to human disease testing the hypothesis that p16(INK4A) methylation is associated with decreased dietary folate.	Folic Acid	189-195	cyclin dependent kinase inhibitor 2A	Homo sapiens	129-132
16646054-4	2006	In an ongoing population-based study of HNSCC, we sought to extend this observation to human disease testing the hypothesis that p16(INK4A) methylation is associated with decreased dietary folate.	Folic Acid	189-195	cyclin dependent kinase inhibitor 2A	Homo sapiens	133-138
16646054-6	2006	In 169 HNSCCs, the odds ratio for p16(INK4A) methylation among those with low dietary folate intake was 2.3 (95% CI = 1.1-4.8) when compared with those with high folate intake.	Folic Acid	86-92	cyclin dependent kinase inhibitor 2A	Homo sapiens	34-37
16646054-6	2006	In 169 HNSCCs, the odds ratio for p16(INK4A) methylation among those with low dietary folate intake was 2.3 (95% CI = 1.1-4.8) when compared with those with high folate intake.	Folic Acid	86-92	cyclin dependent kinase inhibitor 2A	Homo sapiens	38-43
16646054-7	2006	Furthermore, this increased risk for epigenetic silencing at p16(INK4A) was modified by the MTHFR alleles previously associated with diminished serum folate levels.	Folic Acid	150-156	cyclin dependent kinase inhibitor 2A	Homo sapiens	61-64
16646054-7	2006	Furthermore, this increased risk for epigenetic silencing at p16(INK4A) was modified by the MTHFR alleles previously associated with diminished serum folate levels.	Folic Acid	150-156	cyclin dependent kinase inhibitor 2A	Homo sapiens	65-70
16646054-8	2006	Hence, in HNSCC low dietary intake of folate is associated with p16(INK4A) methylation, and this relationship is modified by the MTHFR genotype.	Folic Acid	38-44	cyclin dependent kinase inhibitor 2A	Homo sapiens	64-67
16646054-8	2006	Hence, in HNSCC low dietary intake of folate is associated with p16(INK4A) methylation, and this relationship is modified by the MTHFR genotype.	Folic Acid	38-44	cyclin dependent kinase inhibitor 2A	Homo sapiens	68-73
16832597-0	2006	Folic acid rivals methylenetetrahydrofolate reductase (MTHFR) gene-silencing effect on MEPM cell proliferation and apoptosis.	Folic Acid	0-10	methylenetetrahydrofolate reductase	Mus musculus	55-60
16985020-5	2006	Furthermore, a significant reduction in recurrence risk was seen in MTRR A66G heterozygotes who received folate supplements but not in those who did not receive folate.	Folic Acid	105-111	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	68-72
16712799-10	2006	FDH-resistant cells have strongly up-regulated dihydrofolate reductase (DHFR) that is proposed to be a mechanism for the alteration of folate pools and a key component of the acquired resistance.	Folic Acid	54-60	aldehyde dehydrogenase 1 family member L1	Homo sapiens	0-3
16491109-0	2006	Effect of short-term folic acid supplementation on insulin sensitivity and inflammatory markers in overweight subjects.	Folic Acid	21-31	insulin	Homo sapiens	51-58
16491109-4	2006	In this study, we investigated the effect of folic acid supplementation on insulin sensitivity and peripheral markers of inflammation in overweight healthy subjects.	Folic Acid	45-55	insulin	Homo sapiens	75-82
16491109-8	2006	RESULTS: Subjects receiving folic acid supplementation showed a decrement of homocysteine and an amelioration of insulin sensitivity; this treatment was also associated with a significant drop in the circulating concentration of monocyte chemoattractant protein-1, interleukin-8 and C-reactive protein, in the absence of any significant variation of BMI or fat mass.	Folic Acid	28-38	insulin	Homo sapiens	113-120
16491109-8	2006	RESULTS: Subjects receiving folic acid supplementation showed a decrement of homocysteine and an amelioration of insulin sensitivity; this treatment was also associated with a significant drop in the circulating concentration of monocyte chemoattractant protein-1, interleukin-8 and C-reactive protein, in the absence of any significant variation of BMI or fat mass.	Folic Acid	28-38	C-X-C motif chemokine ligand 8	Homo sapiens	265-278
16491109-8	2006	RESULTS: Subjects receiving folic acid supplementation showed a decrement of homocysteine and an amelioration of insulin sensitivity; this treatment was also associated with a significant drop in the circulating concentration of monocyte chemoattractant protein-1, interleukin-8 and C-reactive protein, in the absence of any significant variation of BMI or fat mass.	Folic Acid	28-38	C-reactive protein	Homo sapiens	283-301
16917148-2	2006	We demonstrate herein that dietary deprivation of folate and vitamin E, coupled with iron as a pro-oxidant, fosters an increase in nonphospho- and-phospho-tau within brain tissue of mice homozygously lacking apolipoprotein E as assayed by monoclonal antibodies Tau-1 and PHF-1, respectively.	Folic Acid	50-56	apolipoprotein E	Mus musculus	208-224
16627483-3	2006	FDH has been proposed to: 1) inhibit purine biosynthesis by depleting 10-formyl-THF pools, 2) maintain cellular folate concentrations by sequestering THF, 3) deplete the supply of folate-activated one-carbon units, and 4) stimulate the generation of THF-activated one-carbon unit synthesis by channeling folate cofactors to other folate-dependent enzymes.	Folic Acid	112-118	aldehyde dehydrogenase 1 family member L1	Homo sapiens	0-3
16627483-3	2006	FDH has been proposed to: 1) inhibit purine biosynthesis by depleting 10-formyl-THF pools, 2) maintain cellular folate concentrations by sequestering THF, 3) deplete the supply of folate-activated one-carbon units, and 4) stimulate the generation of THF-activated one-carbon unit synthesis by channeling folate cofactors to other folate-dependent enzymes.	Folic Acid	180-186	aldehyde dehydrogenase 1 family member L1	Homo sapiens	0-3
16627483-3	2006	FDH has been proposed to: 1) inhibit purine biosynthesis by depleting 10-formyl-THF pools, 2) maintain cellular folate concentrations by sequestering THF, 3) deplete the supply of folate-activated one-carbon units, and 4) stimulate the generation of THF-activated one-carbon unit synthesis by channeling folate cofactors to other folate-dependent enzymes.	Folic Acid	180-186	aldehyde dehydrogenase 1 family member L1	Homo sapiens	0-3
16627483-3	2006	FDH has been proposed to: 1) inhibit purine biosynthesis by depleting 10-formyl-THF pools, 2) maintain cellular folate concentrations by sequestering THF, 3) deplete the supply of folate-activated one-carbon units, and 4) stimulate the generation of THF-activated one-carbon unit synthesis by channeling folate cofactors to other folate-dependent enzymes.	Folic Acid	180-186	aldehyde dehydrogenase 1 family member L1	Homo sapiens	0-3
16627483-5	2006	Both low and high FDH expression reduced total cellular folate concentrations by 60%, elevated rates of folate catabolism, and depleted cellular 5-methyl-THF and S-adenosylmethionine levels.	Folic Acid	56-62	aldehyde dehydrogenase 1 family member L1	Homo sapiens	18-21
16627483-5	2006	Both low and high FDH expression reduced total cellular folate concentrations by 60%, elevated rates of folate catabolism, and depleted cellular 5-methyl-THF and S-adenosylmethionine levels.	Folic Acid	104-110	aldehyde dehydrogenase 1 family member L1	Homo sapiens	18-21
16627483-8	2006	We conclude that low FDH expression facilitates the incorporation of one-carbon units into the one-carbon pool, whereas high levels of FDH expression deplete the folate-activated one-carbon pool by catalyzing the conversion of 10-formyl-THF to THF.	Folic Acid	162-168	aldehyde dehydrogenase 1 family member L1	Homo sapiens	135-138
16627483-10	2006	FDH expression does deplete cellular 5-methyl-THF and S-adenosylmethionine levels indicating that FDH impairs the folate-dependent homocysteine remethylation cycle.	Folic Acid	114-120	aldehyde dehydrogenase 1 family member L1	Homo sapiens	0-3
16627483-10	2006	FDH expression does deplete cellular 5-methyl-THF and S-adenosylmethionine levels indicating that FDH impairs the folate-dependent homocysteine remethylation cycle.	Folic Acid	114-120	aldehyde dehydrogenase 1 family member L1	Homo sapiens	98-101
16819203-0	2006	Folate-linked lipid-based nanoparticles deliver a NFkappaB decoy into activated murine macrophage-like RAW264.7 cells.	Folic Acid	0-6	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	50-58
16819203-2	2006	We investigated delivery of a nuclear factor kappa B (NFkappaB) decoy by folate-linked lipid-based nanoparticles (NP-F) into murine macrophages.	Folic Acid	73-79	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	30-52
16819203-2	2006	We investigated delivery of a nuclear factor kappa B (NFkappaB) decoy by folate-linked lipid-based nanoparticles (NP-F) into murine macrophages.	Folic Acid	73-79	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	54-62
16504977-0	2006	High-dose folic acid supplements and responsiveness to rHu-EPO in HD patients.	Folic Acid	10-20	erythropoietin	Homo sapiens	59-62
16815871-14	2006	Thalidomide and PGA also significantly inhibited P-glycoprotein (PgP/MDR1), multidrug resistance-associated protein (MRP1)- and MRP2-mediated CPT-11 and SN-38 transport in MDCKII cells.	Folic Acid	16-19	ATP binding cassette subfamily C member 2	Canis lupus familiaris	128-132
16362298-8	2006	Moreover, studies from our laboratory demonstrated that folates could modulate the expression and activity of at least two members of the MDR transporters: MRP1/ABCC1, and the breast cancer resistance protein BCRP/ABCG2.	Folic Acid	56-63	ATP binding cassette subfamily C member 1	Homo sapiens	156-160
16362298-8	2006	Moreover, studies from our laboratory demonstrated that folates could modulate the expression and activity of at least two members of the MDR transporters: MRP1/ABCC1, and the breast cancer resistance protein BCRP/ABCG2.	Folic Acid	56-63	ATP binding cassette subfamily C member 1	Homo sapiens	161-166
16362298-8	2006	Moreover, studies from our laboratory demonstrated that folates could modulate the expression and activity of at least two members of the MDR transporters: MRP1/ABCC1, and the breast cancer resistance protein BCRP/ABCG2.	Folic Acid	56-63	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	176-208
16362298-8	2006	Moreover, studies from our laboratory demonstrated that folates could modulate the expression and activity of at least two members of the MDR transporters: MRP1/ABCC1, and the breast cancer resistance protein BCRP/ABCG2.	Folic Acid	56-63	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	209-213
16362298-8	2006	Moreover, studies from our laboratory demonstrated that folates could modulate the expression and activity of at least two members of the MDR transporters: MRP1/ABCC1, and the breast cancer resistance protein BCRP/ABCG2.	Folic Acid	56-63	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	214-219
16362298-9	2006	Thus, folate supplementation may have differential effects on chemotherapy: (1) reduction of toxicity, (2) increase of antitumor activity, and (3) induction of MRP1 and BCRP associated cellular drug resistance.	Folic Acid	6-12	ATP binding cassette subfamily C member 1	Homo sapiens	160-164
16362298-9	2006	Thus, folate supplementation may have differential effects on chemotherapy: (1) reduction of toxicity, (2) increase of antitumor activity, and (3) induction of MRP1 and BCRP associated cellular drug resistance.	Folic Acid	6-12	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	169-173
16774490-5	2006	Folic acid supplementation may mask the anaemia associated with vitamin B12 deficiency and, therefore, may delay treatment while allowing progression of neurological symptoms.	Folic Acid	0-10	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	72-75
16728583-0	2006	Folic acid and its metabolites modulate IGF-I receptor gene expression in colon cancer cells in a p53-dependent manner.	Folic Acid	0-10	tumor protein p53	Homo sapiens	98-101
16818564-3	2006	We hypothesized that combined administration of vitamin B12 and folate with erythropoietin and iron would enhance erythropoietin-induced erythropoiesis.	Folic Acid	64-70	erythropoietin	Homo sapiens	114-128
16818564-5	2006	RESULTS: During the 4-week observation period, vitamin B12 and folate enhanced erythropoietin-induced erythropoiesis significantly, as indicated by a 10% increase in red blood cell counts, compared with folate alone.	Folic Acid	63-69	erythropoietin	Homo sapiens	79-93
16818564-5	2006	RESULTS: During the 4-week observation period, vitamin B12 and folate enhanced erythropoietin-induced erythropoiesis significantly, as indicated by a 10% increase in red blood cell counts, compared with folate alone.	Folic Acid	203-209	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	55-58
16818564-5	2006	RESULTS: During the 4-week observation period, vitamin B12 and folate enhanced erythropoietin-induced erythropoiesis significantly, as indicated by a 10% increase in red blood cell counts, compared with folate alone.	Folic Acid	203-209	erythropoietin	Homo sapiens	79-93
16818564-9	2006	CONCLUSIONS: With the limitation of a slight imbalance in baseline data between the study groups, combined therapy with vitamin B12, folate, erythropoietin, and orally and intravenously administered iron seemed more effective in stimulating erythropoiesis among premature infants, compared with erythropoietin, iron, and low-dose folate alone.	Folic Acid	133-139	erythropoietin	Homo sapiens	295-309
16818564-9	2006	CONCLUSIONS: With the limitation of a slight imbalance in baseline data between the study groups, combined therapy with vitamin B12, folate, erythropoietin, and orally and intravenously administered iron seemed more effective in stimulating erythropoiesis among premature infants, compared with erythropoietin, iron, and low-dose folate alone.	Folic Acid	330-336	erythropoietin	Homo sapiens	141-155
16933212-11	2006	Administration of folic acid to diabetic rats increased NF-kappaB activity and Bcl-2 protein level.	Folic Acid	18-28	BCL2, apoptosis regulator	Rattus norvegicus	79-84
16627483-0	2006	Regulation of folate-mediated one-carbon metabolism by 10-formyltetrahydrofolate dehydrogenase.	Folic Acid	14-20	aldehyde dehydrogenase 1 family member L1	Homo sapiens	55-94
16627483-1	2006	10-Formyltetrahydrofolate dehydrogenase (FDH) catalyzes the NADP(+)-dependent conversion of 10-formyltetrahydrofolate to CO(2) and tetrahydrofolate (THF) and is an abundant high affinity folate-binding protein.	Folic Acid	19-25	aldehyde dehydrogenase 1 family member L1	Homo sapiens	41-44
16627483-2	2006	Although several activities have been ascribed to FDH, its metabolic role in folate-mediated one-carbon metabolism is not well understood.	Folic Acid	77-83	aldehyde dehydrogenase 1 family member L1	Homo sapiens	50-53
16728583-10	2006	In addition, folic acid abrogated the IGF-I-stimulated phosphorylation of the downstream signaling molecule ERK1/2 and exhibited a pro-apoptotic activity.	Folic Acid	13-23	insulin like growth factor 1	Homo sapiens	38-43
16728583-10	2006	In addition, folic acid abrogated the IGF-I-stimulated phosphorylation of the downstream signaling molecule ERK1/2 and exhibited a pro-apoptotic activity.	Folic Acid	13-23	mitogen-activated protein kinase 3	Homo sapiens	108-114
16728583-14	2006	The ability of folic acid to downregulate the IGF-I signal transduction pathway may allow the micronutrient to function as a chemopreventive agent.	Folic Acid	15-25	insulin like growth factor 1	Homo sapiens	46-51
16496414-0	2006	Prostate specific membrane antigen (PSMA) expression gives prostate cancer cells a growth advantage in a physiologically relevant folate environment in vitro.	Folic Acid	130-136	folate hydrolase 1	Homo sapiens	0-34
16672315-0	2006	Role of parathyroid hormone-related protein in tubulointerstitial apoptosis and fibrosis after folic acid-induced nephrotoxicity.	Folic Acid	95-105	parathyroid hormone-like peptide	Mus musculus	8-43
16496414-0	2006	Prostate specific membrane antigen (PSMA) expression gives prostate cancer cells a growth advantage in a physiologically relevant folate environment in vitro.	Folic Acid	130-136	folate hydrolase 1	Homo sapiens	36-40
16496414-2	2006	We studied if PSMA folate hydrolase activity provides cells a growth advantage in a low folate (LF) micro-environment by hydrolyzing extracellular poly-gamma-glutamated folate to a form that cells can import.	Folic Acid	19-25	folate hydrolase 1	Homo sapiens	14-18
16611376-0	2006	In vitro folate deficiency induces apoptosis by a p53, Fas (Apo-1, CD95) independent, bcl-2 related mechanism in phytohaemagglutinin-stimulated human peripheral blood lymphocytes.	Folic Acid	9-15	tumor protein p53	Homo sapiens	50-53
16226775-10	2006	When the folate supplementation dose was increased to 200 mg/kg in the diet, the incidence of rescued splotch homozygotes reached 30%; however, this was accompanied by six-fold increased resorption rate.	Folic Acid	9-15	paired box 3	Mus musculus	102-109
16611376-4	2006	The results indicate that p53 expression was downregulated in folate-deficient lymphocytes when compared with the control lymphocytes during the relevant period of S phase accumulation and apoptosis.	Folic Acid	62-68	tumor protein p53	Homo sapiens	26-29
16611376-0	2006	In vitro folate deficiency induces apoptosis by a p53, Fas (Apo-1, CD95) independent, bcl-2 related mechanism in phytohaemagglutinin-stimulated human peripheral blood lymphocytes.	Folic Acid	9-15	BCL2 apoptosis regulator	Homo sapiens	86-91
16611376-5	2006	In addition, folate deficiency was also found to downregulate IL-2, Fas antigen and bcl-2 expression, in terms of either mRNA or protein levels.	Folic Acid	13-19	interleukin 2	Homo sapiens	62-66
16611376-5	2006	In addition, folate deficiency was also found to downregulate IL-2, Fas antigen and bcl-2 expression, in terms of either mRNA or protein levels.	Folic Acid	13-19	BCL2 apoptosis regulator	Homo sapiens	84-89
16454580-0	2006	Influence of human serum albumin on photodegradation of folic acid in solution.	Folic Acid	56-66	albumin	Homo sapiens	19-32
16611376-9	2006	These results suggest that IL-2 depletion by folate deficiency in lymphocytes reduces the bcl-2 level, thereby triggering deoxynucleoside triphosphate pool imbalance and p53-independent apoptosis.	Folic Acid	45-51	interleukin 2	Homo sapiens	27-31
16611376-9	2006	These results suggest that IL-2 depletion by folate deficiency in lymphocytes reduces the bcl-2 level, thereby triggering deoxynucleoside triphosphate pool imbalance and p53-independent apoptosis.	Folic Acid	45-51	BCL2 apoptosis regulator	Homo sapiens	90-95
16611376-9	2006	These results suggest that IL-2 depletion by folate deficiency in lymphocytes reduces the bcl-2 level, thereby triggering deoxynucleoside triphosphate pool imbalance and p53-independent apoptosis.	Folic Acid	45-51	tumor protein p53	Homo sapiens	170-173
16454580-2	2006	The photodegradation of folic acid (FA) induced by ultraviolet-A (UV-A) radiation, in solution and in the presence of human serum albumin (HSA), was studied with absorption and fluorescence spectroscopy.	Folic Acid	24-34	albumin	Homo sapiens	124-137
16585403-11	2006	In addition, folic acid and infusions of vitamin C are able to restore eNOS functionality, most probably by enhancing BH4 levels as well.	Folic Acid	13-23	nitric oxide synthase 3	Homo sapiens	71-75
28094675-2	2006	OBJECTIVE: To examine the association between rates of age-related cognitive change and dietary intakes of folate and vitamin B12.	Folic Acid	107-113	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	126-129
16681436-9	2006	RESULTS: The pattern of changes was the same for the ACTH and cortisol groups; there were significant decreases in serum concentrations of folate (23% and 24%) and cobalamines (13% and 19%) and decreases in plasma total homocysteine concentrations that did not reach significance.	Folic Acid	139-145	proopiomelanocortin	Homo sapiens	53-57
16112698-9	2006	Folic acid also reduced VPA-induced alterations in p53, NF-kappaB, Pim-1, c-Myb, and Bax/Bcl-2 protein levels, while pantothenic acid prevented VPA-induced alterations in NF-kappaB, Pim-1, and c-Myb.	Folic Acid	0-10	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	56-65
16112698-9	2006	Folic acid also reduced VPA-induced alterations in p53, NF-kappaB, Pim-1, c-Myb, and Bax/Bcl-2 protein levels, while pantothenic acid prevented VPA-induced alterations in NF-kappaB, Pim-1, and c-Myb.	Folic Acid	0-10	B cell leukemia/lymphoma 2	Mus musculus	89-94
16169148-1	2006	Altered maternal folate status and homozygous mutation in the methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) genes can promote chromosomal instability and non-dysjunction resulting in fetal trisomy 21.	Folic Acid	17-23	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	141-145
16910166-1	2006	Folate deficiency increases neuronal oxidative damage and potentiates the deleterious effects of apolipoprotein E (ApoE) deficiency.	Folic Acid	0-6	apolipoprotein E	Mus musculus	97-113
16910166-1	2006	Folate deficiency increases neuronal oxidative damage and potentiates the deleterious effects of apolipoprotein E (ApoE) deficiency.	Folic Acid	0-6	apolipoprotein E	Mus musculus	115-119
16910166-2	2006	Mice lacking ApoE (ApoE -/- mice) upregulate the expression and activity of another enzyme, glutathione synthase (GS), when deprived of folate, in an apparent attempt to compensate for increased oxidative damage.	Folic Acid	136-142	apolipoprotein E	Mus musculus	13-17
16910166-2	2006	Mice lacking ApoE (ApoE -/- mice) upregulate the expression and activity of another enzyme, glutathione synthase (GS), when deprived of folate, in an apparent attempt to compensate for increased oxidative damage.	Folic Acid	136-142	apolipoprotein E	Mus musculus	19-23
16910166-4	2006	Expression and activity of methylene tetrahydrofolate reductase was increased in the order ApoE +/+ &lt; ApoE +/- &lt; ApoE -/- in response to folate deprivation.	Folic Acid	47-53	apolipoprotein E	Mus musculus	91-95
16910166-4	2006	Expression and activity of methylene tetrahydrofolate reductase was increased in the order ApoE +/+ &lt; ApoE +/- &lt; ApoE -/- in response to folate deprivation.	Folic Acid	47-53	apolipoprotein E	Mus musculus	105-109
16910166-4	2006	Expression and activity of methylene tetrahydrofolate reductase was increased in the order ApoE +/+ &lt; ApoE +/- &lt; ApoE -/- in response to folate deprivation.	Folic Acid	47-53	apolipoprotein E	Mus musculus	105-109
16910166-6	2006	By contrast, expression and activity of methionine synthase decreased following folate deprivation in the order ApoE +/+ &lt; ApoE +/- &lt; ApoE -/-.	Folic Acid	80-86	apolipoprotein E	Mus musculus	112-116
16910166-6	2006	By contrast, expression and activity of methionine synthase decreased following folate deprivation in the order ApoE +/+ &lt; ApoE +/- &lt; ApoE -/-.	Folic Acid	80-86	apolipoprotein E	Mus musculus	126-130
16910166-6	2006	By contrast, expression and activity of methionine synthase decreased following folate deprivation in the order ApoE +/+ &lt; ApoE +/- &lt; ApoE -/-.	Folic Acid	80-86	apolipoprotein E	Mus musculus	126-130
16472386-13	2006	In multivariate analysis, intakes of MUFA, fibre, calcium, magnesium, folate, and vitamins A, E, C, B1, and B6 were positively associated with serum folate.	Folic Acid	149-155	immunoglobulin kappa variable 7-3 (pseudogene)	Homo sapiens	97-110
17087642-2	2006	The methionine synthase reductase (MTRR) enzyme restores methionine synthase (MTR) enzyme activity and therefore plays an essential role in the folate- and vitamin B(12)-dependent remethylation of homocysteine to methionine.	Folic Acid	144-150	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	4-33
17087642-2	2006	The methionine synthase reductase (MTRR) enzyme restores methionine synthase (MTR) enzyme activity and therefore plays an essential role in the folate- and vitamin B(12)-dependent remethylation of homocysteine to methionine.	Folic Acid	144-150	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	35-39
16315005-2	2006	Given its key role in folate metabolism, the methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) gene could represent an attractive candidate in NTD aetiology.	Folic Acid	22-28	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	45-86
16315005-2	2006	Given its key role in folate metabolism, the methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) gene could represent an attractive candidate in NTD aetiology.	Folic Acid	22-28	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	88-94
16111879-0	2006	Decreased TGF-beta1 and IGF-1 protein expression in rat embryo skull bone in folic acid-restricted diet.	Folic Acid	77-87	transforming growth factor, beta 1	Rattus norvegicus	10-19
16111879-11	2006	The folic acid-restricted diet (5 microg) resulted in decreased serum TGF-beta1 and IGF-1 levels.	Folic Acid	4-14	transforming growth factor, beta 1	Rattus norvegicus	70-79
16111879-12	2006	Furthermore, protein expression of TGF-beta1 and IGF-1 in E18-19 rat skull bones was also significantly lower in the folic acid-restricted diet than in the normal diet.	Folic Acid	117-127	transforming growth factor, beta 1	Rattus norvegicus	35-44
16256389-6	2006	We hypothesized that a known functional polymorphism (Ile120Val) in the human PCMT1 gene is associated with an increased risk of folate-responsive human NTDs.	Folic Acid	129-135	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Homo sapiens	78-83
16144854-8	2006	The removal of folic acid supplementation resulted in re-occurrence of macrocytosis and in a significantly lower response to rHu-EPO.	Folic Acid	15-25	erythropoietin	Homo sapiens	129-132
17117898-1	2006	BACKGROUND: The nitric oxide synthase (NOS3) G894T gene polymorphism seems as a genetic determinant of total homocysteine (tHcy) concentrations through an effect on folate catabolism.	Folic Acid	165-171	nitric oxide synthase 3	Homo sapiens	39-43
16133045-14	2005	Furthermore, the substantial (post-folate) reduction in the EPO requirement validates the need for therapeutic intervention, and therefore the presence of functional FD in the population.	Folic Acid	35-41	erythropoietin	Homo sapiens	60-63
16562822-4	2006	It is important to identify adequately the exact vitamin deficiency that causes megaloblastic anemia, because vitamin B12 administration in folate deficiency may correct partially megaloblastic alterations, but administration of folic acid in cobalamin deficient patients improves haematological parameters but deteriorates the neurological syndrome.	Folic Acid	140-146	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	118-121
16306263-5	2005	To validate this concept, we prepared a low-density lipoprotein (LDL)-based folate receptor (FR)-targeted agent by conjugating folic acid to the Lys residues of the apolipoprotein B (apoB)-100 protein.	Folic Acid	127-137	apolipoprotein B	Homo sapiens	165-192
16385189-0	2005	Effects of chronic ethanol ingestion and folate deficiency on the activity of 10-formyltetrahydrofolate dehydrogenase in rat liver.	Folic Acid	41-47	aldehyde dehydrogenase 1 family, member L1	Rattus norvegicus	78-117
16317120-10	2005	Overall, these data suggest that the GNMT 1289 C--&gt;T polymorphism influences plasma homocysteine and is responsive to folate intake.	Folic Acid	121-127	glycine N-methyltransferase	Homo sapiens	37-41
16274753-1	2005	Two promoters of the murine methylenetetrahydrofolate reductase gene (Mthfr), a key enzyme in folate metabolism, were characterized in Neuro-2a, NIH/3T3 and RAW 264.7 cells.	Folic Acid	47-53	methylenetetrahydrofolate reductase	Mus musculus	70-75
16139916-2	2005	Folate receptor-specific intracellular delivery of the rev-caspase-3 gene into KB cells over-expressing folate receptors was explored by employing the folate-poly(ethylene glycol)-polyethylenimine (FOL-PEG-PEI) conjugate as a nonviral polymeric carrier.	Folic Acid	104-110	caspase 3	Homo sapiens	59-68
15967214-7	2005	Thus, low folate intake and compounds that are detoxified by NQO1 may be important in elevating leukemia risk in children.	Folic Acid	10-16	NAD(P)H quinone dehydrogenase 1	Homo sapiens	61-65
16266457-10	2005	(3) The addition of folic acid reduced PAI-1 but increased tPA at both mRNA and protein levels, which were both obvious at concentrations of 500 micromol/L Hcy, compared with only Hcy group (P &lt; 0.05).	Folic Acid	20-30	plasminogen activator, tissue type	Homo sapiens	59-62
16317120-0	2005	The glycine N-methyltransferase (GNMT) 1289 C-&gt;T variant influences plasma total homocysteine concentrations in young women after restricting folate intake.	Folic Acid	145-151	glycine N-methyltransferase	Homo sapiens	4-31
16317120-0	2005	The glycine N-methyltransferase (GNMT) 1289 C-&gt;T variant influences plasma total homocysteine concentrations in young women after restricting folate intake.	Folic Acid	145-151	glycine N-methyltransferase	Homo sapiens	33-37
16317120-1	2005	Glycine N-methyltransferase (GNMT) is a key regulatory protein in folate metabolism, methionine availability, and transmethylation reactions.	Folic Acid	66-72	glycine N-methyltransferase	Homo sapiens	0-27
16317120-1	2005	Glycine N-methyltransferase (GNMT) is a key regulatory protein in folate metabolism, methionine availability, and transmethylation reactions.	Folic Acid	66-72	glycine N-methyltransferase	Homo sapiens	29-33
16042580-0	2005	Methylation of the ESR1 CpG island in the colorectal mucosa is an "all or nothing" process in healthy human colon, and is accelerated by dietary folate supplementation in the mouse.	Folic Acid	145-151	estrogen receptor 1	Homo sapiens	19-23
16042580-6	2005	Preliminary studies with a rodent model suggest the rate of age-dependent methylation of ESR1 is modifiable by dietary folate.	Folic Acid	119-125	estrogen receptor 1	Homo sapiens	89-93
16103452-2	2005	Thus, deficient folate status has been hypothesized to be associated primarily with ER gene-negative breast tumors, but data relating folate intake to breast cancer risk according to ER status are sparse.	Folic Acid	16-22	estrogen receptor 1	Homo sapiens	84-86
16103452-5	2005	Higher total folate intake was significantly associated with lower risk of developing ER- but not ER+ breast cancer; the multivariable relative risks (RR) and 95% confidence intervals (95% CI) comparing the highest to the lowest quintile were 0.81 (0.66-0.99) for ER- tumors and 1.00 (0.89-1.14) for ER+ tumors.	Folic Acid	13-19	estrogen receptor 1	Homo sapiens	86-88
16103452-6	2005	The inverse association between total folate intake and ER- breast cancer was mainly present among women consuming at least 15 g/d of alcohol (multivariable RR, 0.46; 95% CI,=0.25-0.86; top versus bottom quintile).	Folic Acid	38-44	estrogen receptor 1	Homo sapiens	56-58
16103452-7	2005	These findings support the hypothesis that higher folate intake reduces the risk of developing ER- breast cancer.	Folic Acid	50-56	estrogen receptor 1	Homo sapiens	95-97
15979267-2	2005	MTHFR is a critical enzyme in folate metabolism; the product of the MTHFR reaction, 5-methyltetrahydrofolate, is required for homocysteine remethylation to methionine and synthesis of S-adenosylmethionine (SAM).	Folic Acid	30-36	methylenetetrahydrofolate reductase	Mus musculus	0-5
15979267-2	2005	MTHFR is a critical enzyme in folate metabolism; the product of the MTHFR reaction, 5-methyltetrahydrofolate, is required for homocysteine remethylation to methionine and synthesis of S-adenosylmethionine (SAM).	Folic Acid	30-36	methylenetetrahydrofolate reductase	Mus musculus	68-73
16043029-13	2005	Our results suggest that more than 400 pg/ml of vitamin B12 in plasma in subjects with a positive folate balance is critical for genomic stability and indicate that the amount of UrMis into DNA is related to the MTHFR genotype.	Folic Acid	98-104	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	56-59
15899950-16	2005	CONCLUSIONS: These results show that folic acid supplementation lowers plasma Hcy levels and improves insulin and lipid metabolism, reducing the risk of cardiovascular disease.	Folic Acid	37-47	insulin	Homo sapiens	102-109
16043029-0	2005	Uracil misincorporation into DNA of leukocytes of young women with positive folate balance depends on plasma vitamin B12 concentrations and methylenetetrahydrofolate reductase polymorphisms.	Folic Acid	76-82	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	117-120
15057566-5	2005	C-reactive protein levels also correlated significantly in a negative manner with vitamin B12 and folate but positively with tHcy.	Folic Acid	98-104	C-reactive protein	Homo sapiens	0-18
16002818-2	2005	The possible role of a mild deficiency in methylenetetrahydrofolate reductase (MTHFR) and low dietary folate in pregnancy outcomes and heart morphogenesis requires further investigation.	Folic Acid	61-67	methylenetetrahydrofolate reductase	Mus musculus	79-84
15939916-3	2005	Now that folic acid fortification is widespread in North America, vitamin B12 has become an important determinant of homocysteine levels.	Folic Acid	9-19	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	74-77
15800852-4	2005	In genetic NTD models such as Cart1, splotch, Cited2, and crooked tail, and NTD induced by teratogens including valproic acid and fumonisins, the incidence of defects is reduced by maternal folic acid supplementation.	Folic Acid	190-200	paired box 3	Mus musculus	37-44
15800852-4	2005	In genetic NTD models such as Cart1, splotch, Cited2, and crooked tail, and NTD induced by teratogens including valproic acid and fumonisins, the incidence of defects is reduced by maternal folic acid supplementation.	Folic Acid	190-200	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	Mus musculus	46-52
15975157-8	2005	Neonatal RBC folate was predicted by maternal RBC folate (b 0.08 (95 % CI 0.04, 0.11), P=0.001; n 315) and maternal vitamin B12 (b 0.08 (95 % CI 0.01, 0.16), P=0.02; n 252).	Folic Acid	13-19	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	124-127
15837926-2	2005	PSMA acts as a glutamate carboxypeptidase (GCPII) on small molecule substrates, including folate, the anticancer drug methotrexate, and the neuropeptide N-acetyl-l-aspartyl-l-glutamate.	Folic Acid	90-96	folate hydrolase 1	Homo sapiens	0-4
15837926-2	2005	PSMA acts as a glutamate carboxypeptidase (GCPII) on small molecule substrates, including folate, the anticancer drug methotrexate, and the neuropeptide N-acetyl-l-aspartyl-l-glutamate.	Folic Acid	90-96	folate hydrolase 1	Homo sapiens	43-48
15777559-5	2005	After patients with HHcy underwent low-dose folic acid treatment (0.8 mg/d) for 6 months, plasma Hcy levels were decreased and the hyper-responsiveness of MCP-1 and IL-8 secreted by isolated monocytes was significantly reversed.	Folic Acid	44-54	C-X-C motif chemokine ligand 8	Homo sapiens	165-169
15849796-7	2005	Molecular studies of the MTHFR (methylenetetrahydrofolate reductase) gene identified a compound heterozygote genotype for two polymorphisms, 677C&gt;T and 1298A&gt;C. CONCLUSION: The fragility at 10q23.3 is unlikely to be due to culture condition-induced folic acid deficiency (medium contains folate).	Folic Acid	51-57	methylenetetrahydrofolate reductase	Mus musculus	25-30
15824266-2	2005	OBJECTIVE: To examine the association between rates of age-related cognitive change and dietary intakes of folate and vitamin B12.	Folic Acid	107-113	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	126-129
15851851-3	2005	Mice deficient in apolipoprotein E, which provide a model for some aspects of AD, undergo increased oxidative damage to brain tissue and cognitive decline when maintained on a folate-free diet, despite a compensatory increase in glutathione synthase transcription and activity as well as increased levels of GSH.	Folic Acid	176-182	apolipoprotein E	Mus musculus	18-34
15657365-0	2005	Cytoplasmic confinement of breast cancer resistance protein (BCRP/ABCG2) as a novel mechanism of adaptation to short-term folate deprivation.	Folic Acid	122-128	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	27-59
15657365-0	2005	Cytoplasmic confinement of breast cancer resistance protein (BCRP/ABCG2) as a novel mechanism of adaptation to short-term folate deprivation.	Folic Acid	122-128	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	61-65
15657365-0	2005	Cytoplasmic confinement of breast cancer resistance protein (BCRP/ABCG2) as a novel mechanism of adaptation to short-term folate deprivation.	Folic Acid	122-128	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	66-71
15657365-1	2005	The unique capability of breast cancer resistance protein (BCRP/ABCG2) to export mono-, di-, and triglutamates of folates should limit cellular proliferation under conditions of folate deprivation, particularly upon BCRP overexpression.	Folic Acid	114-121	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	25-57
15657365-1	2005	The unique capability of breast cancer resistance protein (BCRP/ABCG2) to export mono-, di-, and triglutamates of folates should limit cellular proliferation under conditions of folate deprivation, particularly upon BCRP overexpression.	Folic Acid	114-121	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	59-63
15657365-1	2005	The unique capability of breast cancer resistance protein (BCRP/ABCG2) to export mono-, di-, and triglutamates of folates should limit cellular proliferation under conditions of folate deprivation, particularly upon BCRP overexpression.	Folic Acid	114-121	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	64-69
15657365-1	2005	The unique capability of breast cancer resistance protein (BCRP/ABCG2) to export mono-, di-, and triglutamates of folates should limit cellular proliferation under conditions of folate deprivation, particularly upon BCRP overexpression.	Folic Acid	114-121	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	216-220
15657365-1	2005	The unique capability of breast cancer resistance protein (BCRP/ABCG2) to export mono-, di-, and triglutamates of folates should limit cellular proliferation under conditions of folate deprivation, particularly upon BCRP overexpression.	Folic Acid	114-120	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	25-57
15657365-1	2005	The unique capability of breast cancer resistance protein (BCRP/ABCG2) to export mono-, di-, and triglutamates of folates should limit cellular proliferation under conditions of folate deprivation, particularly upon BCRP overexpression.	Folic Acid	114-120	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	59-63
15657365-1	2005	The unique capability of breast cancer resistance protein (BCRP/ABCG2) to export mono-, di-, and triglutamates of folates should limit cellular proliferation under conditions of folate deprivation, particularly upon BCRP overexpression.	Folic Acid	114-120	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	64-69
15657365-1	2005	The unique capability of breast cancer resistance protein (BCRP/ABCG2) to export mono-, di-, and triglutamates of folates should limit cellular proliferation under conditions of folate deprivation, particularly upon BCRP overexpression.	Folic Acid	114-120	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	216-220
15657365-2	2005	Here, we explored the mode of adaptation of BCRP-overexpressing cells to short-term folate deprivation.	Folic Acid	84-90	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	44-48
15657365-3	2005	MCF-7/MR cells grown in high folate medium (2.3 muM folic acid) containing mitoxantrone had 62% of their overexpressed BCRP in the plasma membrane and only 38% in the cytoplasm.	Folic Acid	52-62	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	119-123
15657365-4	2005	In contrast, cells grown for 2 weeks in folic acid-free medium followed by an adaptation week in low folate medium (1 nM folic acid) had 86% of BCRP in the cytoplasm and only 14% in the plasma membrane.	Folic Acid	40-50	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	144-148
15657365-4	2005	In contrast, cells grown for 2 weeks in folic acid-free medium followed by an adaptation week in low folate medium (1 nM folic acid) had 86% of BCRP in the cytoplasm and only 14% in the plasma membrane.	Folic Acid	101-107	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	144-148
15657365-4	2005	In contrast, cells grown for 2 weeks in folic acid-free medium followed by an adaptation week in low folate medium (1 nM folic acid) had 86% of BCRP in the cytoplasm and only 14% in the plasma membrane.	Folic Acid	121-131	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	144-148
15657365-6	2005	Folate deprivation was also associated with a 3-fold decrease in BCRP and multidrug resistance protein 1 (MRP1/ABCC1) levels.	Folic Acid	0-6	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	65-69
15657365-6	2005	Folate deprivation was also associated with a 3-fold decrease in BCRP and multidrug resistance protein 1 (MRP1/ABCC1) levels.	Folic Acid	0-6	ATP binding cassette subfamily B member 1	Homo sapiens	74-104
15657365-6	2005	Folate deprivation was also associated with a 3-fold decrease in BCRP and multidrug resistance protein 1 (MRP1/ABCC1) levels.	Folic Acid	0-6	ATP binding cassette subfamily C member 1	Homo sapiens	106-110
15657365-6	2005	Folate deprivation was also associated with a 3-fold decrease in BCRP and multidrug resistance protein 1 (MRP1/ABCC1) levels.	Folic Acid	0-6	ATP binding cassette subfamily C member 1	Homo sapiens	111-116
15657365-7	2005	Confocal microscopy with folate-deprived cells revealed that cytoplasmic BCRP colocalized with calnexin, an established endoplasmic reticulum resident.	Folic Acid	25-31	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	73-77
15657365-8	2005	The loss of BCRP from the plasma membrane in folate-deprived cells consistently resulted in a 4.5-fold increase in [(3)H]folic acid accumulation relative to MCF-7/MR cells.	Folic Acid	121-131	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	12-16
15657365-9	2005	Hence, cellular adaptation to shortterm folate deprivation results in a selective confinement of BCRP to the cytoplasm along with a moderate decrease in BCRP and MRP1 levels aimed at preserving the poor intracellular folate pools.	Folic Acid	40-46	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	97-101
15657365-9	2005	Hence, cellular adaptation to shortterm folate deprivation results in a selective confinement of BCRP to the cytoplasm along with a moderate decrease in BCRP and MRP1 levels aimed at preserving the poor intracellular folate pools.	Folic Acid	40-46	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	153-157
15657365-9	2005	Hence, cellular adaptation to shortterm folate deprivation results in a selective confinement of BCRP to the cytoplasm along with a moderate decrease in BCRP and MRP1 levels aimed at preserving the poor intracellular folate pools.	Folic Acid	40-46	ATP binding cassette subfamily C member 1	Homo sapiens	162-166
15657365-9	2005	Hence, cellular adaptation to shortterm folate deprivation results in a selective confinement of BCRP to the cytoplasm along with a moderate decrease in BCRP and MRP1 levels aimed at preserving the poor intracellular folate pools.	Folic Acid	217-223	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	153-157
15657365-10	2005	These results constitute a novel mechanism of cellular adaptation to short-term folate deprivation and provide further support to the possible role of BCRP in the maintenance of cellular folate homeostasis.	Folic Acid	80-86	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	151-155
15657365-10	2005	These results constitute a novel mechanism of cellular adaptation to short-term folate deprivation and provide further support to the possible role of BCRP in the maintenance of cellular folate homeostasis.	Folic Acid	187-193	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	151-155
15924087-0	2005	[Acute neurological disclosure of B12 avitaminosis induced by folic acid administration].	Folic Acid	62-72	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	34-37
15924087-4	2005	Pathophysiological hypotheses tentatively explaining the neurotoxicity of folic acid in case of vitamin B12 deficiency are summarized.	Folic Acid	74-84	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	104-107
15499634-5	2005	Increasing plasma levels of folate and vitamin B12 were statistically significantly associated with increased prostate cancer risk, with an odds ratio of 1.60 (95% CI = 1.03-2.49; p(trend) = 0.02) for folate and 2.63 (95% CI = 1.61-4.29; p(trend) &lt; 0.001) for vitamin B12 for highest vs. lowest quartile.	Folic Acid	28-34	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	271-274
15786529-0	2005	Effects of folic acid on epithelial apoptosis and expression of Bcl-2 and p53 in premalignant gastric lesions.	Folic Acid	11-21	BCL2 apoptosis regulator	Homo sapiens	64-69
15786529-0	2005	Effects of folic acid on epithelial apoptosis and expression of Bcl-2 and p53 in premalignant gastric lesions.	Folic Acid	11-21	tumor protein p53	Homo sapiens	74-77
15786529-7	2005	Both the epithelial apoptosis rate and the tumor suppressor p53 expression in gastric mucosa significantly increased after folic acid treatment.	Folic Acid	123-133	tumor protein p53	Homo sapiens	60-63
15786529-8	2005	In contrast, the expression of Bcl-2 oncogene protein decreased after folic acid therapy.	Folic Acid	70-80	BCL2 apoptosis regulator	Homo sapiens	31-36
15741530-3	2005	Treatment with folate and mecobalamin (vitamin B12) may improve hyperhomocysteinemia.	Folic Acid	15-21	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	47-50
15499634-5	2005	Increasing plasma levels of folate and vitamin B12 were statistically significantly associated with increased prostate cancer risk, with an odds ratio of 1.60 (95% CI = 1.03-2.49; p(trend) = 0.02) for folate and 2.63 (95% CI = 1.61-4.29; p(trend) &lt; 0.001) for vitamin B12 for highest vs. lowest quartile.	Folic Acid	201-207	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	47-50
15499634-10	2005	On the contrary, vitamin B12, associated with an up to 3-fold increase in risk, and possibly also folate, may even stimulate prostate cancer development.	Folic Acid	98-104	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	25-28
16003948-9	2005	Inhibition studies of human rNAT1 and hamster rNAT2 revealed that folic acid and methotrexate (MTX) are competitive inhibitors of both the unacetylated and acetylated forms of the enzymes, with K(I) values in 50 - 300 micro range.	Folic Acid	66-76	N-acetyltransferase 1	Rattus norvegicus	28-33
15673759-4	2005	P. jirovecii cannot be cultured in vitro; however, heterologous complementation of the P. jirovecii trifunctional folic acid synthesis (PjFAS) genes with an E. coli DHPS-disrupted strain was recently achieved.	Folic Acid	114-124	dihydropteroate synthetase	Escherichia coli	165-169
15719048-11	2005	Homozygous mutation at MTHFR and MTHFD loci made serum folic acid and Vit.B(12) levels slightly decreased and serum Hcy level increased.	Folic Acid	55-65	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	33-38
15653533-6	2005	Supplementary folic acid increased crude protein and casein concentrations in milk of cows fed no supplementary methionine and the effect increased as lactation progressed; it also decreased milk lactose concentration.	Folic Acid	14-24	Weaning weight-maternal milk	Bos taurus	78-82
15653533-6	2005	Supplementary folic acid increased crude protein and casein concentrations in milk of cows fed no supplementary methionine and the effect increased as lactation progressed; it also decreased milk lactose concentration.	Folic Acid	14-24	Weaning weight-maternal milk	Bos taurus	191-195
15653533-7	2005	Folic acid supplements had the opposite effects on milk crude protein, casein, and lactose concentrations in cows fed rumen-protected methionine.	Folic Acid	0-10	Weaning weight-maternal milk	Bos taurus	51-55
15641086-8	2005	RESULTS: When compared to dams fed a folate-replete diet, those dams on a folate-depleted diet developed reduced red cell folates and hyperhomocysteinemia and an inverse dose-dependent upregulation of FR and hnRNP-E1 on GD17 without alterations in cell number in the majority of tissues.	Folic Acid	74-80	poly(rC) binding protein 1	Mus musculus	208-216
15743478-1	2005	A recently developed near-infrared fluorescence-labeled folate probe (NIR2-folate) was tested for in vivo imaging of arthritis using a lipopolysaccharide intra-articular injection model and a KRN transgenic mice serum induction mouse model.	Folic Acid	56-62	phosphatidylinositol transfer protein, membrane-associated 1	Mus musculus	70-74
15743478-5	2005	Excessive folic acid was also given to demonstrate a competitive effect with the NIR2-folate.	Folic Acid	10-20	phosphatidylinositol transfer protein, membrane-associated 1	Mus musculus	81-85
15875363-1	2005	PURPOSE: Reduced-folate transporter-1 (RFT-1), a typical transport protein with 12 membrane-spanning domains, transports reduced-folates, such as N5-methyltetrahydrofolate (MTF), the predominant circulating form of folate.	Folic Acid	129-136	RFT1 homolog	Homo sapiens	9-37
16197296-0	2005	Vitamin B12 deficiency is the dominant nutritional cause of hyperhomocysteinemia in a folic acid-fortified population.	Folic Acid	86-96	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	8-11
15875363-1	2005	PURPOSE: Reduced-folate transporter-1 (RFT-1), a typical transport protein with 12 membrane-spanning domains, transports reduced-folates, such as N5-methyltetrahydrofolate (MTF), the predominant circulating form of folate.	Folic Acid	129-136	RFT1 homolog	Homo sapiens	39-44
15875363-1	2005	PURPOSE: Reduced-folate transporter-1 (RFT-1), a typical transport protein with 12 membrane-spanning domains, transports reduced-folates, such as N5-methyltetrahydrofolate (MTF), the predominant circulating form of folate.	Folic Acid	17-23	RFT1 homolog	Homo sapiens	39-44
15875363-2	2005	RFT-1 is localized to the RPE apical membrane and transports folate from RPE to photoreceptor cells.	Folic Acid	61-67	RFT1 homolog	Homo sapiens	0-5
15875363-3	2005	We asked whether RFT-1 activity in RPE is altered under high folate conditions.	Folic Acid	61-67	RFT1 homolog	Homo sapiens	17-22
15875363-7	2005	The effect of high concentrations of folate on RFT-1 activity was specific.	Folic Acid	37-43	RFT1 homolog	Homo sapiens	47-52
15875363-8	2005	Kinetic analysis showed that folate-induced attenuation of RFT-1 activity was associated with a decrease in the maximal velocity of the transporter, but no change in the substrate affinity.	Folic Acid	29-35	RFT1 homolog	Homo sapiens	59-64
15875363-9	2005	Steady-state levels of RFT-1 mRNA and protein decreased significantly in the presence of excess folate.	Folic Acid	96-102	RFT1 homolog	Homo sapiens	23-28
15875363-10	2005	CONCLUSIONS: Excess folate levels downregulate RFT-1 in RPE.	Folic Acid	20-26	RFT1 homolog	Homo sapiens	47-52
15875363-11	2005	This study represents the first molecular analysis of the regulation of RFT-1 by folate in RPE and reveals attenuation of the activity and expression of a folate transport protein under conditions of high levels of folate.	Folic Acid	81-87	RFT1 homolog	Homo sapiens	72-77
15875363-11	2005	This study represents the first molecular analysis of the regulation of RFT-1 by folate in RPE and reveals attenuation of the activity and expression of a folate transport protein under conditions of high levels of folate.	Folic Acid	155-161	RFT1 homolog	Homo sapiens	72-77
15668660-6	2005	Bivariate analysis showed a significant inverse association between CRP and many nutrients (e.g., carbohydrates, proteins, lipids, thiamine, pyridoxine, tocopherol, and folate), but multiple-regression analysis indicated that only the effect of dietary folate intake was not dependent on other factors.	Folic Acid	169-175	C-reactive protein	Homo sapiens	68-71
15668660-9	2005	This population-based study shows that a higher folate intake, in addition to other known constitutive and lifestyle factors, is significantly associated with a lower serum CRP concentration.	Folic Acid	48-54	C-reactive protein	Homo sapiens	173-176
16351505-9	2005	MTRR polymorphism interacted with the association of folate (P for interaction = 0.04) or vitamin (P for interaction = 0.02) with colorectal cancer, although the other polymorphisms did not interact with any nutrient intake.	Folic Acid	53-59	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	0-4
15607954-4	2005	Here we demonstrate that BACE (beta-secretase), as well as PS1, is regulated by methylation and that the reduction of folate and vitamin B12 in culture medium can cause a reduction of SAM levels with consequent increase in presenilin1 and BACE levels and with increase in A beta production.	Folic Acid	118-124	beta-secretase 1	Homo sapiens	25-29
15607954-4	2005	Here we demonstrate that BACE (beta-secretase), as well as PS1, is regulated by methylation and that the reduction of folate and vitamin B12 in culture medium can cause a reduction of SAM levels with consequent increase in presenilin1 and BACE levels and with increase in A beta production.	Folic Acid	118-124	beta-secretase 1	Homo sapiens	239-243
15607954-4	2005	Here we demonstrate that BACE (beta-secretase), as well as PS1, is regulated by methylation and that the reduction of folate and vitamin B12 in culture medium can cause a reduction of SAM levels with consequent increase in presenilin1 and BACE levels and with increase in A beta production.	Folic Acid	118-124	amyloid beta precursor protein	Homo sapiens	272-278
15750664-2	2005	There is evidence of relationships between intake and status of folate and vitamin B-12 with neurological, cognitive, and memory impairment, but results have been inconsistent.	Folic Acid	64-70	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	83-87
15588157-2	2005	We explored whether blood folate concentrations in healthy Czech population are associated with polymorphisms in 5,10-methylenetetrahydrofolate reductase (MTHFR), folate hydrolase 1 (FOLH1), reduced folate carrier (RFC), and folate receptor (FOLR1) genes.	Folic Acid	26-32	folate hydrolase 1	Homo sapiens	163-181
15588157-2	2005	We explored whether blood folate concentrations in healthy Czech population are associated with polymorphisms in 5,10-methylenetetrahydrofolate reductase (MTHFR), folate hydrolase 1 (FOLH1), reduced folate carrier (RFC), and folate receptor (FOLR1) genes.	Folic Acid	26-32	folate hydrolase 1	Homo sapiens	183-188
15609483-4	2004	Among the polymorphic genes and environmental interactions discussed with respect to prenatal development are those for P-glycoprotein (multidrug resistance protein) and the avermectins; methylenetetrahydrofolate reductase (MTHFR), an enzyme in folate metabolism, and dietary folic acid; transforming growth factor alpha (TGFalpha) and cigarette smoke; and alcohol dehydrogenase (ADH) and cytochrome P-450 (CYP) 2E1 in association with alcohol consumption.	Folic Acid	206-212	ATP binding cassette subfamily B member 1	Homo sapiens	120-134
15613250-8	2004	The attenuation of 7-KC-induced apoptotic damage by high-dose folate supplementation coincided with a partial normalization of mitochondria membrane potential dissipation, a suppression of cytochrome c release and an inhibition of procaspase 3 activation.	Folic Acid	62-68	cytochrome c, somatic	Homo sapiens	189-201
15613250-8	2004	The attenuation of 7-KC-induced apoptotic damage by high-dose folate supplementation coincided with a partial normalization of mitochondria membrane potential dissipation, a suppression of cytochrome c release and an inhibition of procaspase 3 activation.	Folic Acid	62-68	caspase 3	Homo sapiens	231-243
15612980-6	2005	MTRR A66G was also correlated with serum folate.	Folic Acid	41-47	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	0-4
15612980-9	2005	Differences in cobalamin and folate levels with the MTRR A66G and MS A2756G polymorphisms were noted.	Folic Acid	29-35	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	52-56
15609483-4	2004	Among the polymorphic genes and environmental interactions discussed with respect to prenatal development are those for P-glycoprotein (multidrug resistance protein) and the avermectins; methylenetetrahydrofolate reductase (MTHFR), an enzyme in folate metabolism, and dietary folic acid; transforming growth factor alpha (TGFalpha) and cigarette smoke; and alcohol dehydrogenase (ADH) and cytochrome P-450 (CYP) 2E1 in association with alcohol consumption.	Folic Acid	206-212	tumor necrosis factor	Homo sapiens	288-320
15609483-4	2004	Among the polymorphic genes and environmental interactions discussed with respect to prenatal development are those for P-glycoprotein (multidrug resistance protein) and the avermectins; methylenetetrahydrofolate reductase (MTHFR), an enzyme in folate metabolism, and dietary folic acid; transforming growth factor alpha (TGFalpha) and cigarette smoke; and alcohol dehydrogenase (ADH) and cytochrome P-450 (CYP) 2E1 in association with alcohol consumption.	Folic Acid	206-212	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	389-415
15609483-4	2004	Among the polymorphic genes and environmental interactions discussed with respect to prenatal development are those for P-glycoprotein (multidrug resistance protein) and the avermectins; methylenetetrahydrofolate reductase (MTHFR), an enzyme in folate metabolism, and dietary folic acid; transforming growth factor alpha (TGFalpha) and cigarette smoke; and alcohol dehydrogenase (ADH) and cytochrome P-450 (CYP) 2E1 in association with alcohol consumption.	Folic Acid	276-286	ATP binding cassette subfamily B member 1	Homo sapiens	120-134
15609483-4	2004	Among the polymorphic genes and environmental interactions discussed with respect to prenatal development are those for P-glycoprotein (multidrug resistance protein) and the avermectins; methylenetetrahydrofolate reductase (MTHFR), an enzyme in folate metabolism, and dietary folic acid; transforming growth factor alpha (TGFalpha) and cigarette smoke; and alcohol dehydrogenase (ADH) and cytochrome P-450 (CYP) 2E1 in association with alcohol consumption.	Folic Acid	276-286	tumor necrosis factor	Homo sapiens	288-320
15609483-4	2004	Among the polymorphic genes and environmental interactions discussed with respect to prenatal development are those for P-glycoprotein (multidrug resistance protein) and the avermectins; methylenetetrahydrofolate reductase (MTHFR), an enzyme in folate metabolism, and dietary folic acid; transforming growth factor alpha (TGFalpha) and cigarette smoke; and alcohol dehydrogenase (ADH) and cytochrome P-450 (CYP) 2E1 in association with alcohol consumption.	Folic Acid	276-286	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	389-415
15514252-10	2004	T(3)-mediated hyperhomocysteinemia may be due to a 70% decrease in hepatic betaine-homocysteine S-methyltransferase, the enzyme that catalyzes folate-independent remethylation of homocysteine, whereas the RA-mediated stimulation of hepatic homocysteine remethylation by folate-dependent methionine synthase may contribute to lowering plasma homocysteine levels.	Folic Acid	143-149	betaine-homocysteine S-methyltransferase	Rattus norvegicus	75-115
15514252-10	2004	T(3)-mediated hyperhomocysteinemia may be due to a 70% decrease in hepatic betaine-homocysteine S-methyltransferase, the enzyme that catalyzes folate-independent remethylation of homocysteine, whereas the RA-mediated stimulation of hepatic homocysteine remethylation by folate-dependent methionine synthase may contribute to lowering plasma homocysteine levels.	Folic Acid	143-149	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	287-306
15514261-0	2004	Mice deficient in methylenetetrahydrofolate reductase exhibit tissue-specific distribution of folates.	Folic Acid	94-101	methylenetetrahydrofolate reductase	Mus musculus	18-53
15514261-6	2004	In Mthfr -/- mice, plasma total folate levels were approximately 25% of those in wild-type (Mthfr +/+) mice.	Folic Acid	32-38	methylenetetrahydrofolate reductase	Mus musculus	3-8
15347642-9	2004	A diabetic state also increased the activity of the folate-independent homocysteine remethylation enzyme betaine-homocysteine S-methyltransferase, whereas the activity of the folate-dependent enzyme methionine synthase was diminished 52%.	Folic Acid	52-58	betaine-homocysteine S-methyltransferase	Rattus norvegicus	105-145
15476449-0	2004	Insulin resistance and endothelial function are improved after folate and vitamin B12 therapy in patients with metabolic syndrome: relationship between homocysteine levels and hyperinsulinemia.	Folic Acid	63-69	insulin	Homo sapiens	0-7
15476449-1	2004	OBJECTIVE: The purpose of this study was (a) to study whether a folate and vitamin B12 treatment, aimed at decreasing homocysteine levels, might ameliorate insulin resistance and endothelial dysfunction in patients with metabolic syndrome according to the National Cholesterol Education Program-Adult Treatment Panel-III criteria and (b) to evaluate whether, under these metabolic conditions, there is a relationship between hyperhomocysteinemia and insulin resistance.	Folic Acid	64-70	insulin	Homo sapiens	156-163
15476449-1	2004	OBJECTIVE: The purpose of this study was (a) to study whether a folate and vitamin B12 treatment, aimed at decreasing homocysteine levels, might ameliorate insulin resistance and endothelial dysfunction in patients with metabolic syndrome according to the National Cholesterol Education Program-Adult Treatment Panel-III criteria and (b) to evaluate whether, under these metabolic conditions, there is a relationship between hyperhomocysteinemia and insulin resistance.	Folic Acid	64-70	insulin	Homo sapiens	450-457
15476449-11	2004	CONCLUSIONS: Folate and vitamin B12 treatment improved insulin resistance and endothelial dysfunction, along with decreasing homocysteine levels, in patients with metabolic syndrome, suggesting that folic acid has several beneficial effects on cardiovascular disease risk factors.	Folic Acid	13-19	insulin	Homo sapiens	55-62
15217352-1	2004	MTHFR (methylenetetrahydrofolate reductase) catalyses the synthesis of 5-methyltetrahydrofolate, the folate derivative utilized in homocysteine remethylation to methionine.	Folic Acid	26-32	methylenetetrahydrofolate reductase	Mus musculus	0-5
15383696-3	2004	We aimed to evaluate the relationship, if present, between vitamin B12 and folic acid levels and acute cerebral stroke in this study.	Folic Acid	75-85	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	67-70
15075253-0	2004	Folic acid-mediated inhibition of serum-induced activation of EGFR promoter in colon cancer cells.	Folic Acid	0-10	epidermal growth factor receptor	Homo sapiens	62-66
15342116-6	2004	The elevated expression of NMDMC in tumour cells, but not in surrounding normal cells, is predicted to result in significant differences in folate-mediated support for purine synthesis in the two cell types.	Folic Acid	140-146	methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase	Mus musculus	27-32
15321811-2	2004	The 1561T allele of the glutamate carboxypeptidase II gene (GCPII), which codes for folylpoly-gamma-glutamyl carboxypeptidase, may impair intestinal absorption of dietary folates.	Folic Acid	171-178	folate hydrolase 1	Homo sapiens	24-53
15321811-2	2004	The 1561T allele of the glutamate carboxypeptidase II gene (GCPII), which codes for folylpoly-gamma-glutamyl carboxypeptidase, may impair intestinal absorption of dietary folates.	Folic Acid	171-178	folate hydrolase 1	Homo sapiens	60-65
15337665-1	2004	OBJECTIVE: Because glutamate carboxypeptidase II (GCPII) regulates both folate absorption and activation of N-methyl-d-aspartic acid receptors, the authors examined relationships between serum folate concentrations and clinical symptoms in schizophrenia patients.	Folic Acid	72-78	folate hydrolase 1	Homo sapiens	19-48
15337665-1	2004	OBJECTIVE: Because glutamate carboxypeptidase II (GCPII) regulates both folate absorption and activation of N-methyl-d-aspartic acid receptors, the authors examined relationships between serum folate concentrations and clinical symptoms in schizophrenia patients.	Folic Acid	72-78	folate hydrolase 1	Homo sapiens	50-55
15322179-8	2004	Folate or nucleoside repletion of folate-deficient cells rapidly restored T lymphocyte proliferation and normal cell cycle, reduced the DNA uracil content, and lowered the CD4(+) to CD8(+) ratio.	Folic Acid	0-6	CD4 molecule	Homo sapiens	172-175
15353309-7	2004	Data from in vitro studies utilizing colon cancer cell lines suggest that supplemental folic acid or its metabolite 5-methyltetrahydrofolate (5-MTF) attenuates the expression and activation of EGF-receptor (EGFR) as well as proliferation of cells.	Folic Acid	87-97	epidermal growth factor receptor	Homo sapiens	193-205
15353309-7	2004	Data from in vitro studies utilizing colon cancer cell lines suggest that supplemental folic acid or its metabolite 5-methyltetrahydrofolate (5-MTF) attenuates the expression and activation of EGF-receptor (EGFR) as well as proliferation of cells.	Folic Acid	87-97	epidermal growth factor receptor	Homo sapiens	207-211
15353309-8	2004	The folic acid mediated reduction of EGFR function could partly be the result of suppression of EGFR gene through increased methylation of CpG sequences within its promoter.	Folic Acid	4-14	epidermal growth factor receptor	Homo sapiens	37-41
15353309-8	2004	The folic acid mediated reduction of EGFR function could partly be the result of suppression of EGFR gene through increased methylation of CpG sequences within its promoter.	Folic Acid	4-14	epidermal growth factor receptor	Homo sapiens	96-100
15322179-8	2004	Folate or nucleoside repletion of folate-deficient cells rapidly restored T lymphocyte proliferation and normal cell cycle, reduced the DNA uracil content, and lowered the CD4(+) to CD8(+) ratio.	Folic Acid	34-40	CD4 molecule	Homo sapiens	172-175
15272307-1	2004	Mammalian formiminotransferase cyclodeaminase (FTCD), a 0.5 million Dalton homo-octameric enzyme, plays important roles in coupling histidine catabolism with folate metabolism and integrating the Golgi complex with the vimentin intermediate filament cytoskeleton.	Folic Acid	158-164	formimidoyltransferase cyclodeaminase	Homo sapiens	10-45
15338491-7	2004	Independent predictors of a significantly higher percentage of abnormal AST values were lack of folate supplementation (p &lt; 0.001) and untreated hyperlipidemia (p &lt; 0.02).	Folic Acid	96-102	solute carrier family 17 member 5	Homo sapiens	72-75
15472418-1	2004	In cross-sectional studies, low levels of folate and B12 have been shown to be associated with cognitive decline and dementia Evidence for the putative role of folate, vitamin B12 in neurocognitive and other neurological functions comes from reported cases of severe vitamin deficiencies, particularly pernicious anemia, and homozygous defects in genes that encode for enzymes of one-carbon metabolism.	Folic Acid	42-48	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	176-179
15472418-1	2004	In cross-sectional studies, low levels of folate and B12 have been shown to be associated with cognitive decline and dementia Evidence for the putative role of folate, vitamin B12 in neurocognitive and other neurological functions comes from reported cases of severe vitamin deficiencies, particularly pernicious anemia, and homozygous defects in genes that encode for enzymes of one-carbon metabolism.	Folic Acid	160-166	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	53-56
15272307-1	2004	Mammalian formiminotransferase cyclodeaminase (FTCD), a 0.5 million Dalton homo-octameric enzyme, plays important roles in coupling histidine catabolism with folate metabolism and integrating the Golgi complex with the vimentin intermediate filament cytoskeleton.	Folic Acid	158-164	formimidoyltransferase cyclodeaminase	Homo sapiens	47-51
15625773-3	2004	Clinical examination and laboratory findings revealed a PGA syndrome due to the presence of hypergonadotropic hypogonadism, insufficient growth hormone response and thyroid autoimmunity.	Folic Acid	56-59	growth hormone 1	Homo sapiens	137-151
15122597-9	2004	Although compound homozygous variants at cSHMT and MTHFD1 loci had the lowest plasma folate levels compared to other compound genotypes, no significant gene-gene interactions were observed.	Folic Acid	85-91	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	51-57
15047700-7	2004	In contrast, BCRP overexpression was largely retained in MCF-7/MR cells grown in MR-free medium containing 2.3 microm folic acid.	Folic Acid	118-128	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	13-17
15205349-0	2004	p14ARF expression increases dihydrofolate reductase degradation and paradoxically results in resistance to folate antagonists in cells with nonfunctional p53.	Folic Acid	35-41	cyclin dependent kinase inhibitor 2A	Homo sapiens	0-6
15205349-7	2004	Surprisingly, induction of p14(ARF) increased resistance to the folate antagonists methotrexate, trimetrexate, and raltitrexed.	Folic Acid	64-70	cyclin dependent kinase inhibitor 2A	Homo sapiens	27-30
15047700-10	2004	Loss of BCRP expression also resulted in the following: (c) an identical MTX sensitivity in these cell lines thereby losing the approximately 28-fold MTX resistance of the MCF-7/MR cells; (d) an approximately 2-fold increase in the 4- and 24-h accumulation of [(3)H]folic acid.	Folic Acid	266-276	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	8-12
15047700-0	2004	Folate deprivation results in the loss of breast cancer resistance protein (BCRP/ABCG2) expression.	Folic Acid	0-6	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	42-74
15047700-12	2004	Hence, consistent with the mono- and polyglutamate folate exporter function of BCRP, down-regulation of BCRP and increased folylpoly-gamma-glutamate synthetase activity appear to be crucial components of cellular adaptation to folate deficiency conditions.	Folic Acid	51-57	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	79-83
15047700-0	2004	Folate deprivation results in the loss of breast cancer resistance protein (BCRP/ABCG2) expression.	Folic Acid	0-6	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	76-80
15047700-0	2004	Folate deprivation results in the loss of breast cancer resistance protein (BCRP/ABCG2) expression.	Folic Acid	0-6	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	81-86
15047700-1	2004	A role for BCRP in cellular folate homeostasis.	Folic Acid	28-34	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	11-15
15047700-13	2004	This is the first evidence for the possible role of BCRP in the maintenance of cellular folate homeostasis.	Folic Acid	88-94	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	52-56
15047700-2	2004	Breast cancer resistance protein (BCRP/ABCG2) is currently the only ABC transporter that exports mono- and polyglutamates of folates and methotrexate (MTX).	Folic Acid	125-132	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	0-32
15182405-8	2004	Serum folate concentrations in both groups had a significant positive correlation with dietary fibre consumption and a significant inverse correlation with vitamin B12 intake.	Folic Acid	6-12	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	164-167
15047700-2	2004	Breast cancer resistance protein (BCRP/ABCG2) is currently the only ABC transporter that exports mono- and polyglutamates of folates and methotrexate (MTX).	Folic Acid	125-132	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	34-38
15047700-2	2004	Breast cancer resistance protein (BCRP/ABCG2) is currently the only ABC transporter that exports mono- and polyglutamates of folates and methotrexate (MTX).	Folic Acid	125-132	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	39-44
15047700-3	2004	Here we explored the relationship between cellular folate status and BCRP expression.	Folic Acid	51-57	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	69-73
15136061-8	2004	We propose that hyperhomocysteinemia in MTHFR 677TT homozygote smokers is the consequence of mild intracellular folate deficiency caused by a smoking-related reduction of NOS3 activity that is exacerbated when serum folate is low.	Folic Acid	112-118	nitric oxide synthase 3	Homo sapiens	171-175
14742318-9	2004	For postmenopausal women, there was increased likelihood of tumors with p53 mutations among women with higher folate.	Folic Acid	110-116	tumor protein p53	Homo sapiens	72-75
15201481-0	2004	Differential susceptibity of transgenic mice lacking one or both apolipoprotein alleles to folate and vitamin E deprivation.	Folic Acid	91-97	apolipoprotein E	Mus musculus	65-79
15201481-3	2004	Dietary deficiency in folate and vitamin E has previously been shown to potentiate the impact of ApoE deficiency; ApoE-/- mice deprived of folate and vitamin E for 1 month demonstrated increased oxidative damage in brain tissue and impaired cognitive performance as compared to ApoE+/+ mice.	Folic Acid	22-28	apolipoprotein E	Mus musculus	97-101
15201481-3	2004	Dietary deficiency in folate and vitamin E has previously been shown to potentiate the impact of ApoE deficiency; ApoE-/- mice deprived of folate and vitamin E for 1 month demonstrated increased oxidative damage in brain tissue and impaired cognitive performance as compared to ApoE+/+ mice.	Folic Acid	22-28	apolipoprotein E	Mus musculus	114-118
15201481-3	2004	Dietary deficiency in folate and vitamin E has previously been shown to potentiate the impact of ApoE deficiency; ApoE-/- mice deprived of folate and vitamin E for 1 month demonstrated increased oxidative damage in brain tissue and impaired cognitive performance as compared to ApoE+/+ mice.	Folic Acid	22-28	apolipoprotein E	Mus musculus	114-118
15201481-3	2004	Dietary deficiency in folate and vitamin E has previously been shown to potentiate the impact of ApoE deficiency; ApoE-/- mice deprived of folate and vitamin E for 1 month demonstrated increased oxidative damage in brain tissue and impaired cognitive performance as compared to ApoE+/+ mice.	Folic Acid	139-145	apolipoprotein E	Mus musculus	97-101
15201481-3	2004	Dietary deficiency in folate and vitamin E has previously been shown to potentiate the impact of ApoE deficiency; ApoE-/- mice deprived of folate and vitamin E for 1 month demonstrated increased oxidative damage in brain tissue and impaired cognitive performance as compared to ApoE+/+ mice.	Folic Acid	139-145	apolipoprotein E	Mus musculus	114-118
15201481-3	2004	Dietary deficiency in folate and vitamin E has previously been shown to potentiate the impact of ApoE deficiency; ApoE-/- mice deprived of folate and vitamin E for 1 month demonstrated increased oxidative damage in brain tissue and impaired cognitive performance as compared to ApoE+/+ mice.	Folic Acid	139-145	apolipoprotein E	Mus musculus	114-118
15201481-7	2004	ApoE-/- mice, but not +/- or +/+ mice, exhibited impaired cognitive performance in maze trials when deprived of folate and vitamin E.	Folic Acid	112-118	apolipoprotein E	Mus musculus	0-4
15134582-7	2004	The absence of the cystathionine beta synthase enzyme in human vascular cells contributes to the importance of a dual role of folic acid in lowering tHcy through remethylation, as well as, its action of being an electron and hydrogen donor to the essential cofactor tetrahydrobiopterin.	Folic Acid	126-136	cystathionine beta-synthase	Homo sapiens	19-46
15150120-1	2004	Glycine N-methyltransferase (GNMT) affects genetic stability by (a) regulating the ratio of S-adenosylmethionine to S-adenosylhomocystine and (b) binding to folate.	Folic Acid	157-163	glycine N-methyltransferase	Homo sapiens	0-27
15150120-1	2004	Glycine N-methyltransferase (GNMT) affects genetic stability by (a) regulating the ratio of S-adenosylmethionine to S-adenosylhomocystine and (b) binding to folate.	Folic Acid	157-163	glycine N-methyltransferase	Homo sapiens	29-33
15147814-9	2004	In contrast, LNCaP cells expressed mRNA of prostate-specific membrane antigen (PSMA), which interacts with the folate substrate.	Folic Acid	111-117	folate hydrolase 1	Homo sapiens	43-77
15147814-9	2004	In contrast, LNCaP cells expressed mRNA of prostate-specific membrane antigen (PSMA), which interacts with the folate substrate.	Folic Acid	111-117	folate hydrolase 1	Homo sapiens	79-83
15134582-8	2004	This folate shuttle facilitates the important recoupling of the uncoupled endothelial nitric oxide synthase enzyme reaction and may restore the synthesis of the omnipotent endothelial nitric oxide to the vasculature.	Folic Acid	5-11	nitric oxide synthase 3	Homo sapiens	74-107
15122759-4	2004	Ethanol feeding or folate deficiency, separately or in combination, decreased transcript levels of methylenetetrahydrofolate reductase (MTHFR), methionine adenosyltransferase (MAT1A), glycine-N-methyltransferase (GNMT) and S-adenosylhomocysteine hydrolase (SAHH).	Folic Acid	19-25	glycine N-methyltransferase	Homo sapiens	184-211
15135249-1	2004	The association of variants of the gene encoding methionine synthase reductase (MTRR) with hyperhomocysteinemia, folate and Vitamin B(12) status in kidney graft recipients is unknown.	Folic Acid	113-119	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	49-78
15135249-1	2004	The association of variants of the gene encoding methionine synthase reductase (MTRR) with hyperhomocysteinemia, folate and Vitamin B(12) status in kidney graft recipients is unknown.	Folic Acid	113-119	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	80-84
15122759-4	2004	Ethanol feeding or folate deficiency, separately or in combination, decreased transcript levels of methylenetetrahydrofolate reductase (MTHFR), methionine adenosyltransferase (MAT1A), glycine-N-methyltransferase (GNMT) and S-adenosylhomocysteine hydrolase (SAHH).	Folic Acid	19-25	glycine N-methyltransferase	Homo sapiens	213-217
15041471-0	2004	Folate concentration dependent transport activity of the Multidrug Resistance Protein 1 (ABCC1).	Folic Acid	0-6	ATP binding cassette subfamily B member 1	Homo sapiens	57-87
15211800-7	2004	Folic acid upregulated c-IAP2 expression while attenuating Hcy-induced apoptosis and caspase3 activation.	Folic Acid	0-10	caspase 3	Homo sapiens	85-93
15296083-7	2004	CONCLUSIONS: The regular consumption of a folic acid and other vitamins (mainly vitamins B6 and B12) and minerals in a fortified dairy product improves folate status and reduces total plasma homocysteine concentration in healthy women of childbearing age.	Folic Acid	42-52	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	96-99
15296083-7	2004	CONCLUSIONS: The regular consumption of a folic acid and other vitamins (mainly vitamins B6 and B12) and minerals in a fortified dairy product improves folate status and reduces total plasma homocysteine concentration in healthy women of childbearing age.	Folic Acid	152-158	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	96-99
15041471-14	2004	In conclusion, this study demonstrates that the cellular folate status can influence the transport activity of MRP1/ABCC1.	Folic Acid	57-63	ATP binding cassette subfamily C member 1	Homo sapiens	111-115
15041471-14	2004	In conclusion, this study demonstrates that the cellular folate status can influence the transport activity of MRP1/ABCC1.	Folic Acid	57-63	ATP binding cassette subfamily C member 1	Homo sapiens	116-121
15041471-15	2004	These results have potentially important implications in the understanding of the (patho-)physiological roles of MRP1/ABCC1, and possibly other ABC transporter proteins in cellular folate homeostasis and drug resistance.	Folic Acid	181-187	ATP binding cassette subfamily C member 1	Homo sapiens	113-117
15041471-15	2004	These results have potentially important implications in the understanding of the (patho-)physiological roles of MRP1/ABCC1, and possibly other ABC transporter proteins in cellular folate homeostasis and drug resistance.	Folic Acid	181-187	ATP binding cassette subfamily C member 1	Homo sapiens	118-123
15041471-0	2004	Folate concentration dependent transport activity of the Multidrug Resistance Protein 1 (ABCC1).	Folic Acid	0-6	ATP binding cassette subfamily C member 1	Homo sapiens	89-94
15041471-2	2004	In addition, MRP1/ABCC1 mediates cellular export of natural folates, such as folic acid and l-leucovorin.	Folic Acid	60-67	ATP binding cassette subfamily C member 1	Homo sapiens	13-17
15041471-2	2004	In addition, MRP1/ABCC1 mediates cellular export of natural folates, such as folic acid and l-leucovorin.	Folic Acid	60-67	ATP binding cassette subfamily C member 1	Homo sapiens	18-23
15041471-2	2004	In addition, MRP1/ABCC1 mediates cellular export of natural folates, such as folic acid and l-leucovorin.	Folic Acid	77-87	ATP binding cassette subfamily C member 1	Homo sapiens	13-17
15041471-2	2004	In addition, MRP1/ABCC1 mediates cellular export of natural folates, such as folic acid and l-leucovorin.	Folic Acid	77-87	ATP binding cassette subfamily C member 1	Homo sapiens	18-23
15041471-3	2004	In this study we determined whether cellular folate status affected the functional activity of MRP1/ABCC1 mediated efflux of an established substrate, the anthracycline daunorubicin (DNR).	Folic Acid	45-51	ATP binding cassette subfamily C member 1	Homo sapiens	95-99
15041471-3	2004	In this study we determined whether cellular folate status affected the functional activity of MRP1/ABCC1 mediated efflux of an established substrate, the anthracycline daunorubicin (DNR).	Folic Acid	45-51	ATP binding cassette subfamily C member 1	Homo sapiens	100-105
15041471-5	2004	Both types of these moderate- and high-MRP1/ABCC1 expressing cells displayed efflux of DNR when maintained in standard culture media (2.3microM folic acid).	Folic Acid	144-154	ATP binding cassette subfamily C member 1	Homo sapiens	39-43
15041471-5	2004	Both types of these moderate- and high-MRP1/ABCC1 expressing cells displayed efflux of DNR when maintained in standard culture media (2.3microM folic acid).	Folic Acid	144-154	ATP binding cassette subfamily C member 1	Homo sapiens	44-49
15041471-9	2004	When 2008/MRP1 cells were challenged for 2 days in folate-free medium, total cellular DNR efflux was decreased to 43% of the initial efflux rate under folate-rich conditions.	Folic Acid	51-57	ATP binding cassette subfamily C member 1	Homo sapiens	10-14
15041471-9	2004	When 2008/MRP1 cells were challenged for 2 days in folate-free medium, total cellular DNR efflux was decreased to 43% of the initial efflux rate under folate-rich conditions.	Folic Acid	151-157	ATP binding cassette subfamily C member 1	Homo sapiens	10-14
15019156-1	2004	We have demonstrated that folic acid inhibits cell proliferation and epidermal growth factor receptor (EGFR) activation in colon cancer cell lines.	Folic Acid	26-36	epidermal growth factor receptor	Homo sapiens	69-101
15065230-1	2004	BACKGROUND: Associations between low levels of folate and vitamin B12 and cognitive impairment in patients with dementia have been reported.	Folic Acid	47-53	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	66-69
15065230-7	2004	RESULTS: In both patient groups, significantly negative correlations between levels of serum vitamin B12 and red cell folate and the degree of cognitive deterioration were found.	Folic Acid	118-124	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	101-104
15065230-10	2004	CONCLUSIONS: The observed negative correlations between levels of vitamin B12 and folate and cognitive impairment in both AD and FTD patients, raise the possibility of a non-specific etiological role.	Folic Acid	82-88	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	74-77
15019156-1	2004	We have demonstrated that folic acid inhibits cell proliferation and epidermal growth factor receptor (EGFR) activation in colon cancer cell lines.	Folic Acid	26-36	epidermal growth factor receptor	Homo sapiens	103-107
14758571-9	2004	A stepwise regression analysis with tHcy plasma level variations (event A = reduction; event B = increase) as the dependent variable showed that low serum folate and PLP levels and presence of MTHFR T allele were the variables associated with insulin-induced tHcy increase.	Folic Acid	155-161	insulin	Homo sapiens	243-250
14990409-0	2004	Impact of folic acid fortification in the United States: markedly diminished high maternal serum alpha-fetoprotein values.	Folic Acid	10-20	alpha fetoprotein	Homo sapiens	97-114
14990409-3	2004	In this study, we ascertain if the impact of folic acid fortification is better seen at the time of midtrimester prenatal diagnosis by looking at incidence of high maternal serum alpha-fetoprotein (MSAFP) values.	Folic Acid	45-55	alpha fetoprotein	Homo sapiens	179-196
14743434-5	2004	Both normal and ApoE-/- mice demonstrated increased GS activity when deprived of folate and vitamin E.	Folic Acid	81-87	apolipoprotein E	Mus musculus	16-20
14743434-6	2004	However, transcription was increased only in ApoE-/- mice deprived of folate and vitamin E.	Folic Acid	70-76	apolipoprotein E	Mus musculus	45-49
15061579-6	2004	CONCLUSIONS: These results demonstrate the Hcy-lowering potential of parenteral vitamin B12 in folic acid supplemented vitamin B12-replete hemodialysis patients, and indicate the need for formal dose-optimization studies of this simple, inexpensive and promising approach to Hcy reduction in end-stage renal disease.	Folic Acid	95-105	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	88-91
15006076-6	2004	Using multiple linear regression analysis, a higher serum B12 level was significantly associated with higher folate levels, African-American race, and lower mean corpuscular volume.	Folic Acid	109-115	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	58-61
15027166-5	2004	Neurological disorders in vitamin B12 deficiency should worsen when folate is administered without supplementation of vitamin B12.	Folic Acid	68-74	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	34-37
14717604-1	2004	Human methionine synthase reductase (MSR) is a key enzyme in folate and methionine metabolism as it reactivates the catalytically inert cob(II)alamin form of methionine synthase (MS).	Folic Acid	61-67	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	6-35
14717604-1	2004	Human methionine synthase reductase (MSR) is a key enzyme in folate and methionine metabolism as it reactivates the catalytically inert cob(II)alamin form of methionine synthase (MS).	Folic Acid	61-67	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	37-40
12970065-8	2004	In folate-deficient rats, aging induced the down-regulation of immune-related genes, urokinase, p53, insulin-like growth factor binding protein-3 and vav-1 oncogene.	Folic Acid	3-9	vav guanine nucleotide exchange factor 1	Rattus norvegicus	150-164
15633292-8	2004	Folic acid supplementation in non-insulin-treated type 2 diabetes patients, therefore, resulted in a fall in Hsp70, reflecting an improvement in oxidative stress.	Folic Acid	0-10	insulin	Homo sapiens	34-41
15075443-5	2004	Folate deficiency has previously been shown to potentiate the impact of apolipoprotein E (ApoE); ApoE-/- mice deprived of folate demonstrated increased oxidative damage in brain tissue and impaired cognitive performance as compared to normal mice or to ApoE-/- mice receiving folate.	Folic Acid	0-6	apolipoprotein E	Mus musculus	72-88
14694163-7	2004	In contrast, PTHrP-overexpressing mice responded to either ischemic or folic acid-induced renal damage similarly to control mice.	Folic Acid	71-81	parathyroid hormone-like peptide	Mus musculus	13-18
15315171-9	2004	This study suggests that it is necessary to monitor the vitamin B12 deficiency and advocates vitamin B12 supplementation with folate prevention program.	Folic Acid	126-132	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	101-104
15075443-5	2004	Folate deficiency has previously been shown to potentiate the impact of apolipoprotein E (ApoE); ApoE-/- mice deprived of folate demonstrated increased oxidative damage in brain tissue and impaired cognitive performance as compared to normal mice or to ApoE-/- mice receiving folate.	Folic Acid	0-6	apolipoprotein E	Mus musculus	90-94
15075443-5	2004	Folate deficiency has previously been shown to potentiate the impact of apolipoprotein E (ApoE); ApoE-/- mice deprived of folate demonstrated increased oxidative damage in brain tissue and impaired cognitive performance as compared to normal mice or to ApoE-/- mice receiving folate.	Folic Acid	0-6	apolipoprotein E	Mus musculus	97-101
15075443-5	2004	Folate deficiency has previously been shown to potentiate the impact of apolipoprotein E (ApoE); ApoE-/- mice deprived of folate demonstrated increased oxidative damage in brain tissue and impaired cognitive performance as compared to normal mice or to ApoE-/- mice receiving folate.	Folic Acid	0-6	apolipoprotein E	Mus musculus	97-101
15075443-5	2004	Folate deficiency has previously been shown to potentiate the impact of apolipoprotein E (ApoE); ApoE-/- mice deprived of folate demonstrated increased oxidative damage in brain tissue and impaired cognitive performance as compared to normal mice or to ApoE-/- mice receiving folate.	Folic Acid	122-128	apolipoprotein E	Mus musculus	90-94
15075443-5	2004	Folate deficiency has previously been shown to potentiate the impact of apolipoprotein E (ApoE); ApoE-/- mice deprived of folate demonstrated increased oxidative damage in brain tissue and impaired cognitive performance as compared to normal mice or to ApoE-/- mice receiving folate.	Folic Acid	122-128	apolipoprotein E	Mus musculus	97-101
15075443-5	2004	Folate deficiency has previously been shown to potentiate the impact of apolipoprotein E (ApoE); ApoE-/- mice deprived of folate demonstrated increased oxidative damage in brain tissue and impaired cognitive performance as compared to normal mice or to ApoE-/- mice receiving folate.	Folic Acid	122-128	apolipoprotein E	Mus musculus	97-101
15075443-5	2004	Folate deficiency has previously been shown to potentiate the impact of apolipoprotein E (ApoE); ApoE-/- mice deprived of folate demonstrated increased oxidative damage in brain tissue and impaired cognitive performance as compared to normal mice or to ApoE-/- mice receiving folate.	Folic Acid	276-282	apolipoprotein E	Mus musculus	72-88
15075443-5	2004	Folate deficiency has previously been shown to potentiate the impact of apolipoprotein E (ApoE); ApoE-/- mice deprived of folate demonstrated increased oxidative damage in brain tissue and impaired cognitive performance as compared to normal mice or to ApoE-/- mice receiving folate.	Folic Acid	276-282	apolipoprotein E	Mus musculus	97-101
15075443-5	2004	Folate deficiency has previously been shown to potentiate the impact of apolipoprotein E (ApoE); ApoE-/- mice deprived of folate demonstrated increased oxidative damage in brain tissue and impaired cognitive performance as compared to normal mice or to ApoE-/- mice receiving folate.	Folic Acid	276-282	apolipoprotein E	Mus musculus	97-101
15075443-6	2004	Herein, we demonstrate that dietary supplementation with DZA prevented both the increase in oxidative damage and impaired cognition characteristic of ApoE-/- mice following folate deprivation.	Folic Acid	173-179	apolipoprotein E	Mus musculus	150-154
14556233-1	2003	Glutamate carboxypeptidase II (EC 3.4.17.21) catalyzes the hydrolysis (Km = 0.2 microM) of the neuropeptide N-acetylaspartylglutamate to yield N-acetylaspartate and glutamate and also serves as a high-affinity folate hydrolase in the gut, cleaving the polyglutamate chain to permit the absorption of folate.	Folic Acid	210-216	folate hydrolase 1	Mus musculus	0-29
14608380-6	2003	The NTDs in Grhl3-/- embryos are also folate resistant, but unlike those in ct/ct mice, they are resistant to inositol.	Folic Acid	38-44	grainyhead like transcription factor 3	Mus musculus	12-17
14517211-2	2003	We now report that the p53-dependent G1 checkpoint is blocked in human carcinoma cell lines after inhibition of de novo purine synthesis by folate analogs inhibitory to glycinamide ribonucleotide formyltransferase (GART).	Folic Acid	140-146	tumor protein p53	Homo sapiens	23-26
14641930-1	2003	BACKGROUND: Despite of an increasing body of research the associations between vitamin B12 and folate levels and the treatment outcome in depressive disorders are still unsolved.	Folic Acid	95-101	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	87-90
14751825-4	2003	To improve delivery into tumor cells, the AS HER-2 ODN was complexed with our previously established folate-liposome delivery system.	Folic Acid	101-107	erb-b2 receptor tyrosine kinase 2	Homo sapiens	45-50
14751825-5	2003	Cell survival assays and Western blot analysis data demonstrated that folate-liposome mediated AS HER-2 oligonucleotide treatment inhibited cell growth and HER-2 expression, and induced apoptosis in SCC-25CP cells.	Folic Acid	70-76	erb-b2 receptor tyrosine kinase 2	Homo sapiens	98-103
14751825-5	2003	Cell survival assays and Western blot analysis data demonstrated that folate-liposome mediated AS HER-2 oligonucleotide treatment inhibited cell growth and HER-2 expression, and induced apoptosis in SCC-25CP cells.	Folic Acid	70-76	erb-b2 receptor tyrosine kinase 2	Homo sapiens	156-161
14751825-7	2003	Additionally, the combination of folate-liposome-AS HER-2 ODN and CDDP had a synergistic effect on the induction of apoptosis.	Folic Acid	33-39	erb-b2 receptor tyrosine kinase 2	Homo sapiens	52-57
14751825-9	2003	Thus, folate-liposome-mediated delivery of AS HER-2 ODN has potential as a new means of increasing the responsiveness of head and neck cancer to conventional chemotherapy.	Folic Acid	6-12	erb-b2 receptor tyrosine kinase 2	Homo sapiens	46-51
14609557-1	2003	Reduced-folate transporter-1 (RFT-1) transports reduced-folates, such as N5-methyltetrahydrofolate (MTF), the predominant circulating form of folate.	Folic Acid	8-14	RFT1 homolog	Homo sapiens	30-35
14609557-2	2003	In RPE, RFT-1 is localized to the apical membrane and is thought to transport folate from RPE to photoreceptor cells.	Folic Acid	78-84	RFT1 homolog	Homo sapiens	8-13
14608380-7	2003	These findings suggest that residual Grhl3 expression in ct/ct mice may be required for inositol rescue of folate-resistant NTDs.	Folic Acid	107-113	grainyhead like transcription factor 3	Mus musculus	37-42
12969128-7	2003	TNF, a cytokine whose renal expression increases in folic acid nephropathy, induced apoptosis in cultured tubular epithelial cells in a time-dependent manner.	Folic Acid	52-62	tumor necrosis factor	Mus musculus	0-3
14682440-9	2003	RESULTS: Our results showed that the odds ratio (OR) estimates for lower dietary folate intake were 2.0 (95% confidence interval, CI: 0.8-4.8) for cases with a methylated ER alpha gene, 0.6 (95% CI: 0.3-1.5) for cases with an unmethylated ER alpha gene, and 1.6 (95% CI: 0.7-3.8) for cases with unknown methylation status (presumably including cases with both methylated and un-methylated genes).	Folic Acid	81-87	estrogen receptor 1	Homo sapiens	171-179
14682440-9	2003	RESULTS: Our results showed that the odds ratio (OR) estimates for lower dietary folate intake were 2.0 (95% confidence interval, CI: 0.8-4.8) for cases with a methylated ER alpha gene, 0.6 (95% CI: 0.3-1.5) for cases with an unmethylated ER alpha gene, and 1.6 (95% CI: 0.7-3.8) for cases with unknown methylation status (presumably including cases with both methylated and un-methylated genes).	Folic Acid	81-87	estrogen receptor 1	Homo sapiens	239-247
14668662-5	2003	Discussion follows concerning the relationships and roles of AFP in various developmental disorders such as hypothyroidism, folate deficiencies, autoimmune disorders, acquired immunodeficiency disorder (AIDS), congenital heart defects, cystic fibrosis, preeclampsia/hypertension, and platelet aggregation disorders.	Folic Acid	124-130	alpha fetoprotein	Homo sapiens	61-64
14608078-8	2003	Folic acid treatment led to a normalization of homocysteine levels accompanied by a reduction in LOX-1 gene expression (P &lt; 0.02) and in oxLDL-stimulated release of TNFalpha (P &lt; 0.05).	Folic Acid	0-10	tumor necrosis factor	Homo sapiens	168-176
14969141-6	2003	Folic acid, B12 and B6 vitamins are involved in the metabolic removal of homocysteine, but folic acid deficit occurs the most often.	Folic Acid	91-101	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	12-15
14969141-8	2003	RESULTS: Folic acid is an important factor in preventing congenital defects (especially of the neural tube) and for lowering the risk of coronary heart disease and stroke due to hyperhomocysteinemia (together with vitamins B6 and B12).	Folic Acid	9-19	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	230-233
14624028-3	2003	Indeed, folate deprivation, which has been associated with AD, potentiates generation of reactive oxygen species (ROS) by Abeta.	Folic Acid	8-14	amyloid beta precursor protein	Homo sapiens	122-127
14503865-8	2003	Studies of this activity in the presence of folate and a folate analogue support the conclusion that this activity results from an interaction with the DHFR rather than a contaminating phosphatase.	Folic Acid	44-50	dihydrofolate reductase	Escherichia coli	152-156
14503865-8	2003	Studies of this activity in the presence of folate and a folate analogue support the conclusion that this activity results from an interaction with the DHFR rather than a contaminating phosphatase.	Folic Acid	57-63	dihydrofolate reductase	Escherichia coli	152-156
12949938-3	2003	PSMA is a folate hydrolase, which cleaves terminal glutamates from poly- and gamma-glutamated folates; and NAALADase, which hydrolyses alpha-glutamate-linked dipeptide, N-acetyl-aspartyl-glutamate (NAAG) and is a glutamate carboxypeptidase.	Folic Acid	94-101	folate hydrolase 1	Homo sapiens	0-4
12949386-8	2003	Selenium and folate interacted (P &lt; 0.0001) to influence one-carbon metabolism and cancer susceptibility such that the number of aberrant crypts and the concentrations of plasma homocysteine and liver S-adenosylhomocysteine were the highest and the concentrations of plasma folate and liver S-adenosylmethionine and the activity of liver methionine synthase were the lowest in rats fed folate-deficient diets and supplemental selenium.	Folic Acid	13-19	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	341-360
12899944-4	2003	Among the hepatic proteins affected by ethanol, the concomitant supplementation with folic acid to alcoholic mother rats prevented EF-2, RhoGDI-1, ER-60 protease, and gelsolin depletion.	Folic Acid	85-95	eukaryotic translation elongation factor 2	Rattus norvegicus	131-135
12899944-4	2003	Among the hepatic proteins affected by ethanol, the concomitant supplementation with folic acid to alcoholic mother rats prevented EF-2, RhoGDI-1, ER-60 protease, and gelsolin depletion.	Folic Acid	85-95	protein disulfide isomerase family A, member 3	Rattus norvegicus	147-161
12899944-4	2003	Among the hepatic proteins affected by ethanol, the concomitant supplementation with folic acid to alcoholic mother rats prevented EF-2, RhoGDI-1, ER-60 protease, and gelsolin depletion.	Folic Acid	85-95	gelsolin	Rattus norvegicus	167-175
14624028-5	2003	Folate-deprivation and Abeta treatment each induced an increase in ROS, and treatment of folate-deprived cultures with Abeta induced a synergistic increase in ROS.	Folic Acid	89-95	amyloid beta precursor protein	Homo sapiens	119-124
14624028-6	2003	17-beta-estradiol reduced ROS levels in beta-treated, folate-deprived cultures to ROS levels observed in cultures treated with Abeta in the presence of folate, suggesting that this antioxidant was able to prevent the synergistic impact of Abeta and folate deprivation on ROS generation.	Folic Acid	54-60	amyloid beta precursor protein	Homo sapiens	239-244
14624028-6	2003	17-beta-estradiol reduced ROS levels in beta-treated, folate-deprived cultures to ROS levels observed in cultures treated with Abeta in the presence of folate, suggesting that this antioxidant was able to prevent the synergistic impact of Abeta and folate deprivation on ROS generation.	Folic Acid	152-158	amyloid beta precursor protein	Homo sapiens	127-132
14624028-6	2003	17-beta-estradiol reduced ROS levels in beta-treated, folate-deprived cultures to ROS levels observed in cultures treated with Abeta in the presence of folate, suggesting that this antioxidant was able to prevent the synergistic impact of Abeta and folate deprivation on ROS generation.	Folic Acid	152-158	amyloid beta precursor protein	Homo sapiens	127-132
14558247-13	2003	Treatment with parenteral B12 vitamin and folic acid reverted the symptoms, with normalization of the neuropsychological tests and reintegration to work.	Folic Acid	42-52	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	26-29
12874005-13	2003	These results indicate that ABCG2 is a component of the energy-dependent efflux system for certain folates and antifolates, but that its transport characteristics with respect to polyglutamates and reduced folates are not identical to those of multidrug resistance protein family members.	Folic Acid	99-106	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	28-33
12874005-13	2003	These results indicate that ABCG2 is a component of the energy-dependent efflux system for certain folates and antifolates, but that its transport characteristics with respect to polyglutamates and reduced folates are not identical to those of multidrug resistance protein family members.	Folic Acid	115-122	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	28-33
12849871-11	2003	CONCLUSIONS: The prevalence of combined B12 insufficiency with supraphysiological concentrations of serum folate increased from 0.09% pre-fortification to 0.61% post (PR 7.0, 95% CI 2.6-19.2).	Folic Acid	106-112	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	40-43
12849871-14	2003	Because the prevalence of combined B12 insufficiency and supraphysiological concentrations of serum folate may have increased with folic acid food fortification, consideration should be given to confirming this finding, and possibly, to the addition of B12 to folate fortified foods.	Folic Acid	131-141	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	35-38
12814391-3	2003	Our results showed the following: (i) Compared with healthy control subjects (n = 9), patients with hyperhomocysteinaemia (n = 9) had elevated mRNA levels of MMP-9 and tissue inhibitors of metalloproteinases-1 (TIMP-1) in freshly isolated peripheral blood mononuclear cells (PBMCs), which were positively correlated with homocysteine and negatively correlated with folate and vitamin B12 levels.	Folic Acid	365-371	TIMP metallopeptidase inhibitor 1	Homo sapiens	211-217
12814391-5	2003	(iii) During folic acid 6 weeks" treatment, normalization of homocysteine levels was accompanied by a significant reduction in mRNA levels of MMP-9 and TIMP-1 in PBMCs, as well as a marked reduction in oxLDL-stimulated release of MMP enzyme activity.	Folic Acid	13-23	TIMP metallopeptidase inhibitor 1	Homo sapiens	152-158
12855225-3	2003	Two recently identified variants are the 1561C--&gt;T (H475Y) mutation in glutamate carboxypeptidase II (GCPII) and the 80A--&gt;G (H27R) change in the reduced folate carrier RFC-1.	Folic Acid	160-166	folate hydrolase 1	Homo sapiens	74-103
12855225-3	2003	Two recently identified variants are the 1561C--&gt;T (H475Y) mutation in glutamate carboxypeptidase II (GCPII) and the 80A--&gt;G (H27R) change in the reduced folate carrier RFC-1.	Folic Acid	160-166	folate hydrolase 1	Homo sapiens	105-110
12670934-1	2003	Vitamins B12, B6, and folic acid converge at the homocysteine metabolic junction where they support the activities of two key enzymes involved in intracellular homocysteine management, methionine synthase (MS) and cystathionine beta-synthase.	Folic Acid	22-32	cystathionine beta-synthase	Homo sapiens	214-241
12689917-9	2003	CONCLUSIONS: These data indicate that the NOS3 894TT genotype is a risk factor for elevated tHcy in healthy nonsmoking adults with low serum folate and supports the hypothesis that nitric oxide modulates homocysteine through an effect on folate catabolism.	Folic Acid	141-147	nitric oxide synthase 3	Homo sapiens	42-46
12689917-9	2003	CONCLUSIONS: These data indicate that the NOS3 894TT genotype is a risk factor for elevated tHcy in healthy nonsmoking adults with low serum folate and supports the hypothesis that nitric oxide modulates homocysteine through an effect on folate catabolism.	Folic Acid	238-244	nitric oxide synthase 3	Homo sapiens	42-46
12689917-5	2003	In both populations, NOS3 genotype was significantly associated with tHcy concentrations in nonsmokers with low folate (P=0.03 for each).	Folic Acid	112-118	nitric oxide synthase 3	Homo sapiens	21-25
12753319-3	2003	RESULTS: The allele frequency for GCP2 1561C&gt;T was 0.05, and 0.43 for RFC1 80G&gt;A. Heterozygosity or homozygosity for GCP2 1561C&gt;T was associated with higher folate plasma levels compared to patients without mutation (P &lt; 0.0001), while RFC1 80G&gt;A showed no influence.	Folic Acid	166-172	folate hydrolase 1	Homo sapiens	123-127
12801615-0	2003	Methylenetetrahydrofolate reductase (MTHFR) 677C&gt;T and methionine synthase reductase (MTRR) 66A&gt;G polymorphisms: association with serum homocysteine and angiographic coronary artery disease in the era of flour products fortified with folic acid.	Folic Acid	240-250	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	89-93
12753319-6	2003	CONCLUSION: We conclude that GCP2 1561C&gt;T is associated with elevated folate levels.	Folic Acid	73-79	folate hydrolase 1	Homo sapiens	29-33
26984794-2	2003	OBJECTIVE: This study investigates whether low serum folate levels may contribute to depressive mood and difficulties in mental processing in patients with epilepsy treated with anti-epileptic drugs inducing the cytochrome P450.	Folic Acid	53-59	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	212-227
12707400-1	2003	This study was designed to examine the effect of two single nucleotide polymorphisms in the reduced folate carrier 1 (RFC1 80G&gt;A) and the glutamate carboxypeptidase 2 (GCP2 1561C&gt;T) gene on total homocysteine (tHcy) plasma level and folate status in 120 chronic dialysis patients.	Folic Acid	239-245	folate hydrolase 1	Homo sapiens	141-169
12707400-1	2003	This study was designed to examine the effect of two single nucleotide polymorphisms in the reduced folate carrier 1 (RFC1 80G&gt;A) and the glutamate carboxypeptidase 2 (GCP2 1561C&gt;T) gene on total homocysteine (tHcy) plasma level and folate status in 120 chronic dialysis patients.	Folic Acid	239-245	folate hydrolase 1	Homo sapiens	171-175
12707400-2	2003	Red blood cell folate concentration was higher in patients with the GCP2 CT or TT genotype (ANOVA, P = 0.04).	Folic Acid	15-21	folate hydrolase 1	Homo sapiens	68-72
12707400-4	2003	A multivariate analysis confirmed that the GCP2 1561C&gt;T genotype (P = 0.011) had a significant influence on the red blood cell folate concentration.	Folic Acid	130-136	folate hydrolase 1	Homo sapiens	43-47
12707400-5	2003	Overall, serum folate, creatinine, and the GCP2 polymorphism explained nearly 50% of the variance of red blood cell folate.	Folic Acid	116-122	folate hydrolase 1	Homo sapiens	43-47
12707400-8	2003	In conclusion, GCP2 1561C&gt;T, but not RFC1 80G&gt;A, is a predictor of red blood cell folate level in chronic dialysis patients.	Folic Acid	88-94	folate hydrolase 1	Homo sapiens	15-19
12628490-9	2003	These results suggest that down- and up-regulation of MRP1 (and MRP3) expression can influence cellular folate homeostasis, in particular when cellular retention by polyglutamylation of folates is attenuated.	Folic Acid	186-193	ATP binding cassette subfamily C member 1	Homo sapiens	54-58
12626825-4	2003	Based on evidence that abnormal folate and methyl metabolism can lead to DNA hypomethylation and abnormal chromosomal segregation, researchers have observed that mothers with mutation in MTHFR (C677T) and MTRR (A66G) gene have elevated levels of plasma homocysteine.	Folic Acid	32-38	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	205-209
12486126-4	2003	We therefore explored the possibility that folate efflux activity mediated by members of the multidrug resistance protein (MRP) family was impaired in CEM-7A cells.	Folic Acid	43-49	ATP binding cassette subfamily C member 1	Homo sapiens	93-121
12486126-4	2003	We therefore explored the possibility that folate efflux activity mediated by members of the multidrug resistance protein (MRP) family was impaired in CEM-7A cells.	Folic Acid	43-49	ATP binding cassette subfamily C member 1	Homo sapiens	123-126
12486126-12	2003	These results establish for the first time that MRP1 is the primary folate efflux route in CEM leukemia cells and that the loss of folate efflux activity is an efficient means of markedly augmenting cellular folate pools.	Folic Acid	68-74	ATP binding cassette subfamily C member 1	Homo sapiens	48-52
12486126-12	2003	These results establish for the first time that MRP1 is the primary folate efflux route in CEM leukemia cells and that the loss of folate efflux activity is an efficient means of markedly augmenting cellular folate pools.	Folic Acid	131-137	ATP binding cassette subfamily C member 1	Homo sapiens	48-52
12486126-12	2003	These results establish for the first time that MRP1 is the primary folate efflux route in CEM leukemia cells and that the loss of folate efflux activity is an efficient means of markedly augmenting cellular folate pools.	Folic Acid	131-137	ATP binding cassette subfamily C member 1	Homo sapiens	48-52
12486126-13	2003	These findings suggest a functional role for MRP1 in the maintenance of cellular folate homeostasis.	Folic Acid	81-87	ATP binding cassette subfamily C member 1	Homo sapiens	45-49
14584018-9	2003	There is a risk that if folic acid is given to people who have undiagnosed deficiency of vitamin B12 it may lead to neurological damage.	Folic Acid	24-34	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	97-100
12590161-3	2003	As described previously, ApoE-deficient mice displayed increased levels of the endogenous antioxidant glutathione as compared to normal mice, and increased these levels further following folate deprivation.	Folic Acid	187-193	apolipoprotein E	Mus musculus	25-29
12893078-3	2003	The primary objective of the current investigation was to determine whether folic acid would prevent LOH of the three tumor suppressor genes, deleted in colorectal cancer (DCC), adenomatous polyposis coli (APC) and p53 in macroscopically normal appearing rectal mucosa of patients with adenomatous polyps.	Folic Acid	76-86	tumor protein p53	Homo sapiens	215-218
15106288-5	2003	In the acute phase of their disease, the patients with APV exhibited increased plasma levels of fibrinogen (341.5 +/- 136.8 standard deviation [SD] versus 268.1 +/- 72.6 SD mg/dl; p = .05); increased plasma levels of D-dimer (305 +/- 158 SD versus 201 +/- 106 SD ng/dl; p = .008); enhanced plasma levels of lipoprotein (a) (42.6 +/- 38.5 SD versus 16.9 +/- 17.7 SD mg/dl; F = 5.67, p = .02); high leukocyte count (9.2 +/- 2.7 SD versus 6.4 +/- 1.2 SD x 10(3)/microliter; F = 8.42, p &lt; .006); and low serum folate concentration (5.1 +/- 1.7 SD versus 7.2 +/- 2.6 SD ng/ml; F = 4.34, p = .04).	Folic Acid	509-515	fibrinogen beta chain	Homo sapiens	96-106
12628490-0	2003	The role of multidrug resistance proteins MRP1, MRP2 and MRP3 in cellular folate homeostasis.	Folic Acid	74-80	ATP binding cassette subfamily C member 1	Homo sapiens	42-46
12628490-3	2003	In MRP1, MRP2 and MRP3-transfected 2008 human ovarian carcinoma cells total cellular folate content was 32-38% lower than in 2008 cells (105+/-14pmolfolate/mgprotein) when grown in medium containing 2.3 microM folic acid (FA).	Folic Acid	85-91	ATP binding cassette subfamily C member 1	Homo sapiens	3-7
12628490-5	2003	However, when cells were challenged under folate-depleted conditions with a short exposure (4 hr) to FA or leucovorin, MRP1 and MRP3 overexpressing cells were impaired in their growth.	Folic Acid	42-48	ATP binding cassette subfamily C member 1	Homo sapiens	119-123
12628490-9	2003	These results suggest that down- and up-regulation of MRP1 (and MRP3) expression can influence cellular folate homeostasis, in particular when cellular retention by polyglutamylation of folates is attenuated.	Folic Acid	104-110	ATP binding cassette subfamily C member 1	Homo sapiens	54-58
12784029-4	2003	OBJECTIVE: To analyse the correlation between the ApoE and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and plasma homocysteine levels and vitamins (B(12) and folic acid) concentrations in serum from patients with AD and mild cognitive impairment (MCI) as compared with control group.	Folic Acid	177-187	apolipoprotein E	Homo sapiens	50-54
12784029-10	2003	The increased frequency of ApoE4 allele in the AD population was independent of homocysteine, folic acid and vitamin B(12) levels and MTHFR status.	Folic Acid	94-104	apolipoprotein E	Homo sapiens	27-32
12514270-3	2003	Recently, a H475Y polymorphism in the glutamate carboxypeptidase II (GCPII) gene, encoding the FGCP enzyme, was reported to be associated with decreased plasma folate and increased plasma homocysteine (tHcy) levels.	Folic Acid	160-166	folate hydrolase 1	Homo sapiens	38-67
12514270-3	2003	Recently, a H475Y polymorphism in the glutamate carboxypeptidase II (GCPII) gene, encoding the FGCP enzyme, was reported to be associated with decreased plasma folate and increased plasma homocysteine (tHcy) levels.	Folic Acid	160-166	folate hydrolase 1	Homo sapiens	69-74
12514270-0	2003	The H475Y polymorphism in the glutamate carboxypeptidase II gene increases plasma folate without affecting the risk for neural tube defects in humans.	Folic Acid	82-88	folate hydrolase 1	Homo sapiens	30-59
12514270-3	2003	Recently, a H475Y polymorphism in the glutamate carboxypeptidase II (GCPII) gene, encoding the FGCP enzyme, was reported to be associated with decreased plasma folate and increased plasma homocysteine (tHcy) levels.	Folic Acid	160-166	folate hydrolase 1	Homo sapiens	95-99
12514270-8	2003	The H475Y polymorphism in the GCPII gene may increase the deconjugation activity of the FGCP enzyme, resulting in an increased absorption of folate in the body, as reflected by the increased plasma folate and decreased plasma homocysteine concentrations.	Folic Acid	141-147	folate hydrolase 1	Homo sapiens	30-35
12514270-8	2003	The H475Y polymorphism in the GCPII gene may increase the deconjugation activity of the FGCP enzyme, resulting in an increased absorption of folate in the body, as reflected by the increased plasma folate and decreased plasma homocysteine concentrations.	Folic Acid	141-147	folate hydrolase 1	Homo sapiens	88-92
12514270-8	2003	The H475Y polymorphism in the GCPII gene may increase the deconjugation activity of the FGCP enzyme, resulting in an increased absorption of folate in the body, as reflected by the increased plasma folate and decreased plasma homocysteine concentrations.	Folic Acid	198-204	folate hydrolase 1	Homo sapiens	30-35
12514270-8	2003	The H475Y polymorphism in the GCPII gene may increase the deconjugation activity of the FGCP enzyme, resulting in an increased absorption of folate in the body, as reflected by the increased plasma folate and decreased plasma homocysteine concentrations.	Folic Acid	198-204	folate hydrolase 1	Homo sapiens	88-92
12372420-3	2002	For the modification of folate by HOCl, folic acid was reacted with the combination of MPO and H(2)O(2) or NaOCl.	Folic Acid	24-30	myeloperoxidase	Homo sapiens	87-90
12480173-5	2002	However, ApoE knockout mice accumulated significantly increased TBARs following iron challenge when folic acid was withheld, and accumulated even more TBARs when both folic acid and vitamin E were withheld.	Folic Acid	100-110	apolipoprotein E	Mus musculus	9-13
12480173-5	2002	However, ApoE knockout mice accumulated significantly increased TBARs following iron challenge when folic acid was withheld, and accumulated even more TBARs when both folic acid and vitamin E were withheld.	Folic Acid	167-177	apolipoprotein E	Mus musculus	9-13
12374623-6	2002	However, combined treatment with folate deprivation and dietary iron depleted antioxidant capacity and induced oxidative damage in ApoE-deficient brains despite increased glutathione, indicating an inability to compensate for the lack of ApoE under these conditions.	Folic Acid	33-39	apolipoprotein E	Mus musculus	131-135
14716026-0	2003	Folate and vitamin E deficiency impair cognitive performance in mice subjected to oxidative stress: differential impact on normal mice and mice lacking apolipoprotein E.	Folic Acid	0-6	apolipoprotein E	Mus musculus	152-168
14716026-6	2003	Both normal and ApoE-/- mice displayed some cognitive impairment when deprived of folate and vitamin E and exposed to iron, but ApoE-/- mice were more severely affected.	Folic Acid	82-88	apolipoprotein E	Mus musculus	16-20
12372420-3	2002	For the modification of folate by HOCl, folic acid was reacted with the combination of MPO and H(2)O(2) or NaOCl.	Folic Acid	40-50	myeloperoxidase	Homo sapiens	87-90
12204797-0	2002	Influence of a glutamate carboxypeptidase II (GCPII) polymorphism (1561C--&gt;T) on plasma homocysteine, folate and vitamin B(12) levels and its relationship to cardiovascular disease risk.	Folic Acid	105-111	folate hydrolase 1	Homo sapiens	15-44
12204797-3	2002	Glutamate carboxypeptidase II (GCPII) regulates the absorption of dietary folates.	Folic Acid	74-81	folate hydrolase 1	Homo sapiens	0-29
12204797-3	2002	Glutamate carboxypeptidase II (GCPII) regulates the absorption of dietary folates.	Folic Acid	74-81	folate hydrolase 1	Homo sapiens	31-36
12376515-0	2002	Interaction of dietary folate intake, alcohol, and risk of hormone receptor-defined breast cancer in a prospective study of postmenopausal women.	Folic Acid	23-29	nuclear receptor subfamily 4 group A member 1	Homo sapiens	59-75
12482398-9	2002	These two loci harbor the methylenetetrahydrofolate dehydrogenase (MTHFD1) and 5"-methyltetrahdrofolate-homocysteine methyltransferase reductase (MTRR) genes, both of which are involved in folate metabolism.	Folic Acid	45-51	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	67-73
12221287-0	2002	Folate synthesis in plants: the first step of the pterin branch is mediated by a unique bimodular GTP cyclohydrolase I.	Folic Acid	0-6	GTP cyclohydrolase 1	Solanum lycopersicum	98-118
12221287-1	2002	GTP cyclohydrolase I (GCHI) mediates the first and committing step of the pterin branch of the folate-synthesis pathway.	Folic Acid	95-101	GTP cyclohydrolase 1	Solanum lycopersicum	0-20
12221287-1	2002	GTP cyclohydrolase I (GCHI) mediates the first and committing step of the pterin branch of the folate-synthesis pathway.	Folic Acid	95-101	GTP cyclohydrolase 1	Solanum lycopersicum	22-26
12221287-9	2002	The deduced tomato and Arabidopsis GCHI polypeptides lack overt targeting sequences and thus are presumably cytosolic, in contrast to other plant folate-synthesis enzymes, which are mitochondrial proteins with typical signal peptides.	Folic Acid	146-152	GTP cyclohydrolase 1	Solanum lycopersicum	35-39
12221287-10	2002	GCHI mRNA and protein are strongly in expressed unripe tomato fruits, implying that fruit folate is made in situ rather than imported.	Folic Acid	90-96	GTP cyclohydrolase 1	Solanum lycopersicum	0-4
12235471-13	2002	Age and sex differences were confirmed and a significant inverse relationship between plasma homocysteine concentrations and that of serum folate and plasma vitamin B12 was observed.	Folic Acid	139-145	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	165-168
12126848-0	2002	Effect of supplementation with folic-acid on relation between plasma homocysteine, folate, and vitamin B12.	Folic Acid	31-41	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	103-106
12126850-0	2002	Effect of supplementation with folic-acid on relation between plasma homocysteine, folate, and vitamin B12.	Folic Acid	31-41	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	103-106
12810987-5	2002	Ones of those are genes of metabolism of folic acid as MTHFR, MTR, MTRR, CBS, MTHFD, folic acid receptors (FR) regulator genes from PAX family, T, PDGFRA and BRCA1 genes.	Folic Acid	41-51	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	67-71
12810987-5	2002	Ones of those are genes of metabolism of folic acid as MTHFR, MTR, MTRR, CBS, MTHFD, folic acid receptors (FR) regulator genes from PAX family, T, PDGFRA and BRCA1 genes.	Folic Acid	41-51	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	78-83
12810987-5	2002	Ones of those are genes of metabolism of folic acid as MTHFR, MTR, MTRR, CBS, MTHFD, folic acid receptors (FR) regulator genes from PAX family, T, PDGFRA and BRCA1 genes.	Folic Acid	41-51	platelet derived growth factor receptor alpha	Homo sapiens	147-153
12421037-2	2002	We propose that folate administration can precipitate this neurological syndrome in patients with subclinical deficiency of vitamin B12, a phenomenon more likely to occur in tropical countries.	Folic Acid	16-22	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	132-135
12435858-6	2002	MATERIALS AND METHODS: A cationic liposome complex that includes folate as the targeting ligand was designed and optimized for more efficient delivery of AS HER-2 ODN to breast tumors cells in vitro, and more significantly, for systemic delivery with tumor-specific targeting in vivo.	Folic Acid	65-71	erb-b2 receptor tyrosine kinase 2	Homo sapiens	157-162
12435858-9	2002	RESULTS: The optimized folate-liposome-AS HER-2 ODN complex significantly increases the response of breast tumor cell lines to conventional chemotherapeutic agents in vitro as compared to AS HER-2 delivered via an unliganded commercially available reagent, Lipofectin.	Folic Acid	23-29	erb-b2 receptor tyrosine kinase 2	Homo sapiens	42-47
12435858-9	2002	RESULTS: The optimized folate-liposome-AS HER-2 ODN complex significantly increases the response of breast tumor cell lines to conventional chemotherapeutic agents in vitro as compared to AS HER-2 delivered via an unliganded commercially available reagent, Lipofectin.	Folic Acid	23-29	erb-b2 receptor tyrosine kinase 2	Homo sapiens	191-196
12435858-10	2002	In vivo, the folate-liposome-AS HER-2 ODN complex has prolonged stability in blood and increased uptake in tumors.	Folic Acid	13-19	erb-b2 receptor tyrosine kinase 2	Homo sapiens	32-37
12482398-9	2002	These two loci harbor the methylenetetrahydrofolate dehydrogenase (MTHFD1) and 5"-methyltetrahdrofolate-homocysteine methyltransferase reductase (MTRR) genes, both of which are involved in folate metabolism.	Folic Acid	45-51	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	117-144
12482398-9	2002	These two loci harbor the methylenetetrahydrofolate dehydrogenase (MTHFD1) and 5"-methyltetrahdrofolate-homocysteine methyltransferase reductase (MTRR) genes, both of which are involved in folate metabolism.	Folic Acid	45-51	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	146-150
11997266-1	2002	Although the reduced folate carrier RFC1 and the thiamine transporters THTR-1 and THTR-2 share approximately 40% of their identity in protein sequence, RFC1 does not transport thiamine and THTR-1 and THTR-2 do not transport folates.	Folic Acid	21-27	replication factor C (activator 1) 1	Mus musculus	36-40
12136399-5	2002	Therefore we hypothesise that folate improves endothelial function in Type II (non-insulin-dependent) diabetes mellitus in vivo.	Folic Acid	30-36	insulin	Homo sapiens	83-90
11997266-1	2002	Although the reduced folate carrier RFC1 and the thiamine transporters THTR-1 and THTR-2 share approximately 40% of their identity in protein sequence, RFC1 does not transport thiamine and THTR-1 and THTR-2 do not transport folates.	Folic Acid	224-231	replication factor C (activator 1) 1	Mus musculus	36-40
11997266-1	2002	Although the reduced folate carrier RFC1 and the thiamine transporters THTR-1 and THTR-2 share approximately 40% of their identity in protein sequence, RFC1 does not transport thiamine and THTR-1 and THTR-2 do not transport folates.	Folic Acid	224-231	replication factor C (activator 1) 1	Mus musculus	152-156
12110777-7	2002	P-ET-1 decreased during folate supplementation (from 5.7 [2.7-11.6] to 4.1 [1.8-9.0] pg/ml; p&lt;0.01), but was unchanged in the untreated group 4.1 [2.0-9.5] pg/ml and 4.5 [2.7-7.1] pg/ml).	Folic Acid	24-30	FEV transcription factor, ETS family member	Homo sapiens	0-6
12088801-6	2002	Our data also indicate that p53 is required for the folate depletion-induced apoptosis.	Folic Acid	52-58	tumor protein p53	Homo sapiens	28-31
12042430-2	2002	Recently, a 1561 C&gt;T polymorphism in the GCPII gene was reported to be associated with lower folate and higher homocysteine plasma concentrations in a small (n = 75) selected elderly population.	Folic Acid	96-102	folate hydrolase 1	Homo sapiens	44-49
12024029-14	2002	These results show that NMDMC is not required to support initiation of protein synthesis in mitochondria in isolated cells but instead demonstrate an essential role for mitochondrial folate metabolism during embryonic development.	Folic Acid	183-189	methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase	Mus musculus	24-29
11969424-10	2002	The site of electron donation was identified as complex IV, which contains cytochrome c; the folate product was 10-HCO-DHF, and the reaction was saturable with respect to 10-HCO-THF.	Folic Acid	93-99	cytochrome c, somatic	Homo sapiens	75-87
12034806-0	2002	Symptoms of B12 deficiency can occur in women of child bearing age supplemented with folate.	Folic Acid	85-91	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	12-15
12007575-1	2002	The reduced folate carrier (RFC1), a member of the major facilitative superfamily, generates uphill transport of folates into cells through an exchange mechanism with intracellular organic anions.	Folic Acid	12-18	replication factor C (activator 1) 1	Mus musculus	28-32
12007575-1	2002	The reduced folate carrier (RFC1), a member of the major facilitative superfamily, generates uphill transport of folates into cells through an exchange mechanism with intracellular organic anions.	Folic Acid	113-120	replication factor C (activator 1) 1	Mus musculus	28-32
12186157-3	2002	Our study was aimed at finding the relationship between HCA, folate, vitamins B12 levels, and mutations in the 5,10-methylenetetrahydrofolate reductase (MTHFR) and cystathionine beta-synthase (CBS) genes.	Folic Acid	61-67	cystathionine beta-synthase	Homo sapiens	164-191
11969424-12	2002	To our knowledge, this cytochrome c oxidation of 10-HCO-THF to 10-HCO-DHF in the mitochondrial intermembrane space represents a possible folate metabolic pathway previously unidentified and would explain the bioactivity of unnatural carbon-6 isomers, (6R)-5-HCO-THF and (6S)-5,10-CH-THF, in humans.	Folic Acid	137-143	cytochrome c, somatic	Homo sapiens	23-35
11931659-12	2002	Thus the HPPK domain of this bifunctional protein is the limiting factor of the overall reaction, but the DHPS domain is a potential key regulatory point of the whole folate biosynthetic pathway.	Folic Acid	167-173	dihydropteroate synthetase	Escherichia coli	106-110
11956665-5	2002	RESULTS: Folate treatment resulted in a significant decrease of tHcy and fibrinogen, while plasminogen and antithrombin III significantly increased.	Folic Acid	9-15	fibrinogen beta chain	Homo sapiens	73-83
11950713-6	2002	(2) During folic acid treatment, normalization of homocysteine levels was accompanied by a marked reduction in oxidized low density lipoprotein-stimulated release of CXC chemokines (ie, GROalpha, ENA-78, and interleukin-8) and CC chemokines (ie, monocyte chemoattractant peptide-1 and RANTES) in peripheral blood mononuclear cells from these individuals.	Folic Acid	11-21	C-X-C motif chemokine ligand 8	Homo sapiens	208-221
12003352-4	2002	Folate acts directly to produce antioxidant effects, interactions with enzyme endothelial NO synthase (eNOS) and effects on cofactor bioavailability of NO.	Folic Acid	0-6	nitric oxide synthase 3	Homo sapiens	103-107
11777934-10	2002	Folic acid and cAMP activate GCA maximally about 2.5-fold, whereas sGC is activated about 8-fold.	Folic Acid	0-10	grancalcin	Homo sapiens	29-32
11880504-3	2002	Incubation of hippocampal cultures in folic acid-deficient medium or in the presence of methotrexate (an inhibitor of folic acid metabolism) or homocysteine induced cell death and rendered neurons vulnerable to death induced by Abeta.	Folic Acid	38-48	amyloid beta precursor protein	Homo sapiens	228-233
12187485-2	2002	Based on this, we hypothesized that folate would enter the RPE via FR alpha and exit the cell via RFT-1.	Folic Acid	36-42	RFT1 homolog	Homo sapiens	98-103
11863251-8	2002	Folic acid treatment decreases collagen expression and increases TGF-beta1.	Folic Acid	0-10	transforming growth factor, beta 1	Rattus norvegicus	65-74
12187485-8	2002	The presence of FR alpha in the basal membrane was demonstrable by folate binding and that of RFT-1 in the apical membrane by blockade of folate transport by RFT-1-specific antibody.	Folic Acid	138-144	RFT1 homolog	Homo sapiens	94-99
11823447-0	2002	Folic acid prevents exencephaly in Cited2 deficient mice.	Folic Acid	0-10	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	Mus musculus	35-41
12187485-9	2002	This study represents the first in vitro demonstration of transcellular transfer of folate across RPE and suggests that folate is transported from the choriocapillaris to the adjacent photoreceptor cells in vivo by the concerted action of FR alpha in the basal membrane and RFT-1 in the apical membrane.	Folic Acid	120-126	RFT1 homolog	Homo sapiens	274-279
11823447-7	2002	Treatment with folic acid significantly reduced the exencephalic phenotype in the Cited2(-/-) embryos both in vivo and in vitro.	Folic Acid	15-25	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	Mus musculus	82-88
11823447-9	2002	To our knowledge, the Cited2 mouse represents the first genetic model in which folic acid can prevent a defect in neural tube closure by a mechanism other than the neutralization of a defect in folate homeostasis.	Folic Acid	79-89	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	Mus musculus	22-28
11857507-0	2002	Effects of folate supplementation on the risk of spontaneous and induced neural tube defects in Splotch mice.	Folic Acid	11-17	paired box 3	Mus musculus	96-103
11810299-7	2002	GNMT is also inhibited by a specific form of folate, 5-methyltetrahydrofolate pentaglutamate.	Folic Acid	45-51	glycine N-methyltransferase	Homo sapiens	0-4
11807890-1	2002	Polymorphisms in genes encoding the folate metabolizing enzymes methylenetetrahydrofolate reductase (MTHFR C677T) and methionine synthase reductase (MTRR A66G) have been linked to the etiology of Down syndrome.	Folic Acid	36-42	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	118-147
11807890-1	2002	Polymorphisms in genes encoding the folate metabolizing enzymes methylenetetrahydrofolate reductase (MTHFR C677T) and methionine synthase reductase (MTRR A66G) have been linked to the etiology of Down syndrome.	Folic Acid	36-42	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	149-153
12216328-6	2002	Treatment of IRS in regard to endothelial function should be focused initially on lifestyle improvement, such as stopping smoking and eating a balanced diet containing antioxidant vitamins, folic-acid, L-arginine and long-chain omega-3 unsaturated FA.	Folic Acid	190-200	isoleucyl-tRNA synthetase 1	Homo sapiens	13-16
11833752-10	2002	CONCLUSIONS: These data suggest a strong interaction between vitamin B12 and choline deficiencies and folate status in this population, which may be due in part to variations in vitamin and choline delivery by TPN.	Folic Acid	102-108	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	69-72
11833752-0	2002	Choline and vitamin B12 deficiencies are interrelated in folate-replete long-term total parenteral nutrition patients.	Folic Acid	57-63	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	20-23
12734059-11	2002	After adjustment for age, extent of disease, total calories, alcohol, and estrogen receptor status, women with total folate intake in the highest tertile had a mortality risk ratio of 0.88 (95% confidence interval = 0.44-1.76) compared with cases in the lowest tertile of folate.	Folic Acid	117-123	estrogen receptor 1	Homo sapiens	74-91
11729241-0	2001	Increased renal angiopoietin-1 expression in folic acid-induced nephrotoxicity in mice.	Folic Acid	45-55	angiopoietin 1	Mus musculus	16-30
11848192-0	2001	The effects of folic acid application on IL-1beta levels of human gingival fibroblasts stimulated by phenytoin and TNFalpha in vitro: a preliminary study.	Folic Acid	15-25	interleukin 1 beta	Homo sapiens	41-49
11848192-0	2001	The effects of folic acid application on IL-1beta levels of human gingival fibroblasts stimulated by phenytoin and TNFalpha in vitro: a preliminary study.	Folic Acid	15-25	tumor necrosis factor	Homo sapiens	115-123
12038037-0	2002	The C677T thermolabile variant of methylene tetrahydrofolate reductase on homocysteine, folate and vitamin B12 in a hemodialysis center.	Folic Acid	54-60	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	107-110
11686576-0	2001	Folate deficiency-induced oxidative stress and apoptosis are mediated via homocysteine-dependent overproduction of hydrogen peroxide and enhanced activation of NF-kappaB in human Hep G2 cells.	Folic Acid	0-6	nuclear factor kappa B subunit 1	Homo sapiens	160-169
11686576-3	2001	Previously, we demonstrated that the demise of human hepatoma Hep G2 cells mediated by folate deficiency proceeded via a p53-independent apoptosis, and the perturbation of intracellular calcium homeostasis was also shown to be involved.	Folic Acid	87-93	tumor protein p53	Homo sapiens	121-124
11686576-8	2001	Finally, we demonstrated that folate deficiency was indeed capable of activating a redox-sensitive transcription factor, NF-kappaB, which is crucial in the control of a reactive oxygen species-mediated apoptosis.	Folic Acid	30-36	nuclear factor kappa B subunit 1	Homo sapiens	121-130
11686576-9	2001	In summary, we show that folate deficiency-induced apoptosis is proceeded via the enhanced activation of NF-kappaB, which is the resulting form of the homocysteine-mediated overproduction of hydrogen peroxide.	Folic Acid	25-31	nuclear factor kappa B subunit 1	Homo sapiens	105-114
11585759-8	2001	We also show that polyglutamylation similarly affects the capacity of MRP1 to transport MTX and that physiological folates are also subject to MgATP-stimulated transport by MRP1.	Folic Acid	115-122	ATP binding cassette subfamily C member 1	Homo sapiens	173-177
11833752-11	2002	Folate adequacy may increase B12 use for homocysteine metabolism, thus limiting B12 availability for methylmaIonic acid metabolism.	Folic Acid	0-6	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	29-32
11833752-11	2002	Folate adequacy may increase B12 use for homocysteine metabolism, thus limiting B12 availability for methylmaIonic acid metabolism.	Folic Acid	0-6	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	80-83
11514359-0	2001	Effects of breed, parity, and folic acid supplement on the expression of leptin and its receptors" genes in embryonic and endometrial tissues from pigs at day 25 of gestation.	Folic Acid	30-40	leptin	Sus scrofa	73-79
11532093-6	2001	Immunohistochemistry also was performed for PTHrP, the PTH/PTHrP receptor, and Ang II in the renal tissue of folic acid-injected rats.	Folic Acid	109-119	angiotensinogen	Rattus norvegicus	79-85
11443546-2	2001	Thus, recent reports linking Down syndrome to maternal polymorphisms at either of two folate metabolism enzymes, methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR), have generated considerable interest.	Folic Acid	86-92	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	161-190
11443546-2	2001	Thus, recent reports linking Down syndrome to maternal polymorphisms at either of two folate metabolism enzymes, methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR), have generated considerable interest.	Folic Acid	86-92	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	192-196
11391481-10	2001	The increased activity of CBS in children with DS significantly alters homocysteine metabolism such that the folate-dependent resynthesis of methionine is compromised.	Folic Acid	109-115	cystathionine beta-synthase	Homo sapiens	26-29
11483410-1	2001	Calmodulin (CaM) antagonists, trifluoperazine (TFP) or calmidazolium (R24571), dose-dependently inhibited cAMP and folic acid (FA) chemotaxis in Dictyostelium.	Folic Acid	115-125	calmodulin 1	Homo sapiens	0-10
11483410-1	2001	Calmodulin (CaM) antagonists, trifluoperazine (TFP) or calmidazolium (R24571), dose-dependently inhibited cAMP and folic acid (FA) chemotaxis in Dictyostelium.	Folic Acid	115-125	calmodulin 1	Homo sapiens	12-15
11481906-2	2001	Hyperhomocysteinemia may be induced by failure or decreased enzyme activity of the cystathionine-beta-synthase and methylenetetrahydrofolate reductase due to genetic mutation or deficiency of folic acid, vitamin B12 and vitamin B6.	Folic Acid	192-202	cystathionine beta-synthase	Homo sapiens	83-110
11427193-9	2001	These data provide insights into the role that RFC1 plays in folate delivery in a variety of tissues.	Folic Acid	61-67	replication factor C (activator 1) 1	Mus musculus	47-51
11452966-0	2001	Folate and vitamin B12 supplementation in very low birth weight infants treated with erythropoietin: a cautionary note.	Folic Acid	0-6	erythropoietin	Homo sapiens	85-99
11427193-10	2001	In particular, the localization of carrier may elucidate the role of RFC1 in the vectorial transport of folates across epithelia.	Folic Acid	104-111	replication factor C (activator 1) 1	Mus musculus	69-73
11553056-4	2001	We have investigated the relationship between serum concentration of total homocysteine, methylmalonic acid, vitamin B12 and folate in pregnancy.	Folic Acid	125-131	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	117-120
11759218-22	2001	Folic acid (10 mg/day) enhances response to EPO.	Folic Acid	0-10	erythropoietin	Homo sapiens	44-47
11509098-2	2001	Increasing evidence suggests that the beneficial effect of folate may be related to improved function of methionine synthase, a vitamin B12-dependent enzyme that converts homocysteine to methionine.	Folic Acid	59-65	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	136-139
11283497-6	2001	RESULTS: The patients with APV in the acute phase compared with the patients with Meniere"s disease in the acute phase exhibited increased plasma levels of fibrinogen (mean, 338.3 +/- 135.9 SD vs 271.3 +/- 69.8 SD mg/dL, P = 0.05), increased plasma levels of D-dimer (mean, 320 +/- 207.8 SD vs 226.7 +/- 138.7 SD NG/mL), enhanced plasma levels of lipoprotein(a) (41.4 +/- 38.6 SD vs 16 +/- 18.2 SD mg/dL, F = 5.67, P = 0.02), high leukocyte count (9.1 +/- 2.7 SD vs 6.5 +/- 1.3 SD x 10(3)/microL; F = 8.42, P &lt; 0.006), and low serum folate concentration (5.3 +/- 1.8 SD vs 7.1 +/- 2.7 NG/mg; F = 4.34, P = 0.04).	Folic Acid	536-542	fibrinogen beta chain	Homo sapiens	156-166
11106643-1	2001	The relationship between loss of functional p53 and human reduced folate carrier (hRFC) levels and function was examined in REH lymphoblastic leukemia cells, which express wild type p53, and in p53-null K562 cells (K562(pTet-on/p53)) engineered to express wild type p53 under control of a tetracycline-inducible promoter.	Folic Acid	66-72	tumor protein p53	Homo sapiens	44-47
11246591-1	2001	As a public health strategy to help prevent neural tube defect-affected pregnancies, enriched flour and pasta in the United States and Canada are being fortified with folic acid, and women are being advised to take supplementary folic acid around the time of pregnancy to ensure an adequate intake.	Folic Acid	167-177	solute carrier family 45 member 1	Homo sapiens	104-109
11229418-0	2001	Homocysteine, fibrinogen, and lipoprotein(a) levels are simultaneously reduced in patients with chronic renal failure treated with folic acid, pyridoxine, and cyanocobalamin.	Folic Acid	131-141	fibrinogen beta chain	Homo sapiens	14-24
11038362-1	2001	The thiamin transporter encoded by SLC19A2 and the reduced folate carrier (RFC1) share 40% homology at the protein level, but the thiamin transporter does not mediate transport of folates.	Folic Acid	59-65	replication factor C (activator 1) 1	Mus musculus	75-79
11197251-2	2001	This study investigated the effect of folate supplementation on genomic DNA methylation and DNA strand breaks in exons 5-8 of the p53 gene of the colonic mucosa, two provisional biomarkers of colon cancer.	Folic Acid	38-44	tumor protein p53	Homo sapiens	130-133
11197251-7	2001	Similarly, folate supplementation decreased the extent of p53 strand breaks in exons 5-8 at 6 months and 1 yr (p &lt; 0.02), whereas placebo administration was associated with a decrease in the extent of p53 strand breaks only at 1 yr.	Folic Acid	11-17	tumor protein p53	Homo sapiens	58-61
11197251-7	2001	Similarly, folate supplementation decreased the extent of p53 strand breaks in exons 5-8 at 6 months and 1 yr (p &lt; 0.02), whereas placebo administration was associated with a decrease in the extent of p53 strand breaks only at 1 yr.	Folic Acid	11-17	tumor protein p53	Homo sapiens	204-207
11748919-0	2001	Basal levels of metallothionein I and II expression in mouse embryo fibroblasts enhance growth in low folate through a cell cycle mediated pathway.	Folic Acid	102-108	metallothionein 1	Mus musculus	16-40
11590253-8	2001	Deficiencies in vitamin B(12), folic acid and potentially vitamin C can all reduce the efficacy of treatment with rh-Epo.	Folic Acid	31-41	erythropoietin	Homo sapiens	117-120
11254667-2	2001	Here we show that induction of HHcy in apoE-null mice by a diet enriched in methionine but depleted in folate and vitamins B6 and B12 increased atherosclerotic lesion area and complexity, and enhanced expression of receptor for advanced glycation end products (RAGE), VCAM-1, tissue factor, and MMP-9 in the vasculature.	Folic Acid	103-109	apolipoprotein E	Mus musculus	39-43
14728038-6	2001	Vitamin therapy with folate, pyridoxine (vitamin B(6)), and cyanocobalamin (vitamin B(12)) reduces blood levels of homocyst(e)ine, improves endothelial function, reduces levels of fibrinogen and lipoprotein(a), improves thrombolysis, and in uncontrolled clinical observation, leads to regression of carotid plaque.	Folic Acid	21-27	fibrinogen beta chain	Homo sapiens	180-190
11209001-3	2001	The availability of vitamin B(6) and folic acid, as co-factors for Hcy metabolism may affect the response to MLT.	Folic Acid	37-47	mitogen-activated protein kinase kinase kinase 20	Homo sapiens	109-112
11204591-9	2001	This interaction between CBS genotype and MTHFR and MS genotype points to a key role of the CBS transulphuration pathway in the metabolism of homocysteine that may be particularly important as a compensatory mechanism in subjects with low dietary folate.	Folic Acid	247-253	cystathionine beta-synthase	Homo sapiens	25-28
11204591-9	2001	This interaction between CBS genotype and MTHFR and MS genotype points to a key role of the CBS transulphuration pathway in the metabolism of homocysteine that may be particularly important as a compensatory mechanism in subjects with low dietary folate.	Folic Acid	247-253	cystathionine beta-synthase	Homo sapiens	92-95
11092759-0	2000	Glutamate carboxypeptidase II: a polymorphism associated with lower levels of serum folate and hyperhomocysteinemia.	Folic Acid	84-90	folate hydrolase 1	Homo sapiens	0-29
11092759-4	2000	Dietary folates are a mixture of polyglutamylated folates which are digested to monoglutamyl folates by the action of folylpoly-gamma-glutamate carboxypeptidase (FGCP), an enzyme that is anchored to the intestinal brush border membrane and is expressed by the glutamate carboxypepidase II (GCPII) gene.	Folic Acid	8-15	folate hydrolase 1	Homo sapiens	118-160
11092759-4	2000	Dietary folates are a mixture of polyglutamylated folates which are digested to monoglutamyl folates by the action of folylpoly-gamma-glutamate carboxypeptidase (FGCP), an enzyme that is anchored to the intestinal brush border membrane and is expressed by the glutamate carboxypepidase II (GCPII) gene.	Folic Acid	8-15	folate hydrolase 1	Homo sapiens	162-166
11092759-4	2000	Dietary folates are a mixture of polyglutamylated folates which are digested to monoglutamyl folates by the action of folylpoly-gamma-glutamate carboxypeptidase (FGCP), an enzyme that is anchored to the intestinal brush border membrane and is expressed by the glutamate carboxypepidase II (GCPII) gene.	Folic Acid	8-15	folate hydrolase 1	Homo sapiens	260-288
11092759-4	2000	Dietary folates are a mixture of polyglutamylated folates which are digested to monoglutamyl folates by the action of folylpoly-gamma-glutamate carboxypeptidase (FGCP), an enzyme that is anchored to the intestinal brush border membrane and is expressed by the glutamate carboxypepidase II (GCPII) gene.	Folic Acid	8-15	folate hydrolase 1	Homo sapiens	290-295
11092759-4	2000	Dietary folates are a mixture of polyglutamylated folates which are digested to monoglutamyl folates by the action of folylpoly-gamma-glutamate carboxypeptidase (FGCP), an enzyme that is anchored to the intestinal brush border membrane and is expressed by the glutamate carboxypepidase II (GCPII) gene.	Folic Acid	50-57	folate hydrolase 1	Homo sapiens	118-160
11092759-4	2000	Dietary folates are a mixture of polyglutamylated folates which are digested to monoglutamyl folates by the action of folylpoly-gamma-glutamate carboxypeptidase (FGCP), an enzyme that is anchored to the intestinal brush border membrane and is expressed by the glutamate carboxypepidase II (GCPII) gene.	Folic Acid	50-57	folate hydrolase 1	Homo sapiens	162-166
11092759-4	2000	Dietary folates are a mixture of polyglutamylated folates which are digested to monoglutamyl folates by the action of folylpoly-gamma-glutamate carboxypeptidase (FGCP), an enzyme that is anchored to the intestinal brush border membrane and is expressed by the glutamate carboxypepidase II (GCPII) gene.	Folic Acid	50-57	folate hydrolase 1	Homo sapiens	260-288
11092759-4	2000	Dietary folates are a mixture of polyglutamylated folates which are digested to monoglutamyl folates by the action of folylpoly-gamma-glutamate carboxypeptidase (FGCP), an enzyme that is anchored to the intestinal brush border membrane and is expressed by the glutamate carboxypepidase II (GCPII) gene.	Folic Acid	50-57	folate hydrolase 1	Homo sapiens	290-295
11092759-8	2000	The presence of the H475Y GCPII allele was significantly associated with lower folate and higher homocysteine levels in this population.	Folic Acid	79-85	folate hydrolase 1	Homo sapiens	26-31
11092759-9	2000	These data suggest that the presence of the H475Y GCPII allele impairs the intestinal absorption of dietary folates, resulting in relatively low blood folate levels and consequent hyperhomocysteinemia.	Folic Acid	108-115	folate hydrolase 1	Homo sapiens	50-55
11092759-9	2000	These data suggest that the presence of the H475Y GCPII allele impairs the intestinal absorption of dietary folates, resulting in relatively low blood folate levels and consequent hyperhomocysteinemia.	Folic Acid	108-114	folate hydrolase 1	Homo sapiens	50-55
11103808-2	2000	The cystathionine-beta-synthase (CBS) gene (localized to chromosome 21q22.3) may have downstream effects on reduced folate and S-adenosylmethionine pathways; ara-C metabolism and folate pools are linked by the known synergistic effect of sequential methotrexate and ara-C therapy.	Folic Acid	116-122	cystathionine beta-synthase	Homo sapiens	4-31
11103808-2	2000	The cystathionine-beta-synthase (CBS) gene (localized to chromosome 21q22.3) may have downstream effects on reduced folate and S-adenosylmethionine pathways; ara-C metabolism and folate pools are linked by the known synergistic effect of sequential methotrexate and ara-C therapy.	Folic Acid	116-122	cystathionine beta-synthase	Homo sapiens	33-36
11103808-2	2000	The cystathionine-beta-synthase (CBS) gene (localized to chromosome 21q22.3) may have downstream effects on reduced folate and S-adenosylmethionine pathways; ara-C metabolism and folate pools are linked by the known synergistic effect of sequential methotrexate and ara-C therapy.	Folic Acid	179-185	cystathionine beta-synthase	Homo sapiens	33-36
11103808-2	2000	The cystathionine-beta-synthase (CBS) gene (localized to chromosome 21q22.3) may have downstream effects on reduced folate and S-adenosylmethionine pathways; ara-C metabolism and folate pools are linked by the known synergistic effect of sequential methotrexate and ara-C therapy.	Folic Acid	179-185	cystathionine beta-synthase	Homo sapiens	4-31
10889164-3	2000	This study investigated the effects of dietary folate on DNA strand breaks in the p53 and Apc genes, and how these changes are related to steady-state levels of the corresponding transcripts.	Folic Acid	47-53	APC regulator of WNT signaling pathway	Rattus norvegicus	90-93
10833330-6	2000	Furthermore, clinical and experimental evidence imply that allelic forms of genes involved with folate metabolism and/or transport may explain some of the observed variation in the NTD rates found across different populations.	Folic Acid	96-102	fuzzy planar cell polarity protein	Homo sapiens	181-184
10656824-9	2000	SHMT tetramers have surface charge distributions which suggest distinctions in folate binding between eukaryotic and E. coli enzymes.	Folic Acid	79-85	serine hydroxymethyltransferase, cytosolic	Oryctolagus cuniculus	0-4
10601577-1	2000	The folate-sensitive fragile site FRAXE is located in proximal Xq28 of the human X chromosome and lies approximately 600 kb distal to the fragile X syndrome (FRAXA) fragile site at Xq27.3.	Folic Acid	4-10	fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)	Homo sapiens	158-163
10600765-6	1999	Pretreatment of HCT-116 and Caco-2 cell lines with supplemental folic acid (1.25 microg/ml) completely abrogated transforming growth factor-alpha (TGF-alpha)-induced proliferation in both cell lines.	Folic Acid	64-74	transforming growth factor alpha	Homo sapiens	147-156
10600765-8	1999	The folic acid-induced inhibition of EGFR tyrosine kinase activity in colon cancer cell lines was also associated with a concomitant reduction in the relative concentration of the 14-kDa membrane-bound precursor form of TGF-alpha.	Folic Acid	4-14	transforming growth factor alpha	Homo sapiens	220-229
10767323-5	2000	NTD risk is reduced in various models by different maternal nutrient supplements, including folic acid ( Pax3, Cart1, Cd mutants), inositol ( ct ) and methionine ( Axd ).	Folic Acid	92-102	fuzzy planar cell polarity protein	Homo sapiens	0-3
10677373-1	2000	The reduced-folate-carrier (rfc) gene has been shown to be functionally important for reduced-folate transport in mammalian cells.	Folic Acid	12-18	solute carrier family 19 member 1	Homo sapiens	28-31
10677373-9	2000	Thus mutations in both alleles of the rfc gene in this resistant cell line account for the loss of reduced-folate transport.	Folic Acid	107-113	solute carrier family 19 member 1	Homo sapiens	38-41
10525077-7	1999	CeOAT1 exhibits broad specificity, accepting anions such as folate, indomethacin, furosemide, probenecid, and benzylpenicillin as substrates.	Folic Acid	60-66	MFS domain-containing protein	Caenorhabditis elegans	0-6
10508523-7	1999	We also produced mice lacking Folbp2, another member of the folate receptor family that is GPI anchored but binds folate poorly.	Folic Acid	60-66	folate receptor 2 (fetal)	Mus musculus	30-36
10391221-7	1999	Mutations in a new gene, SLC19A2, encoding a putative transmembrane protein homologous to the reduced folate carrier proteins, were found in all affected individuals in six TRMA families, suggesting that a defective thiamine transporter protein (THTR-1) may underlie the TRMA syndrome.	Folic Acid	102-108	solute carrier family 19 member 2	Homo sapiens	25-32
10391221-7	1999	Mutations in a new gene, SLC19A2, encoding a putative transmembrane protein homologous to the reduced folate carrier proteins, were found in all affected individuals in six TRMA families, suggesting that a defective thiamine transporter protein (THTR-1) may underlie the TRMA syndrome.	Folic Acid	102-108	solute carrier family 19 member 2	Homo sapiens	173-177
10391223-5	1999	Here we report the cloning of a new gene, SLC19A2, identified from high-through-put genomic sequences due to homology with SLC19A1, encoding reduced folate carrier 1 (refs 8-10).	Folic Acid	149-155	solute carrier family 19 member 2	Homo sapiens	42-49
10391223-5	1999	Here we report the cloning of a new gene, SLC19A2, identified from high-through-put genomic sequences due to homology with SLC19A1, encoding reduced folate carrier 1 (refs 8-10).	Folic Acid	149-155	solute carrier family 19 member 1	Homo sapiens	123-130
10431526-1	1999	BACKGROUND AND AIMS: To define the frequency of Sicilian pregnant women taking folic acid during the periconceptional period (three months before and two months after conception) and how many are familiar with the preventive effects of folic acid on NTD.	Folic Acid	236-246	fuzzy planar cell polarity protein	Homo sapiens	250-253
10431526-6	1999	Only the 5 pregnant women (0.5%) who took folic acid during the periconceptional period were aware of the possibility of preventing NTD through supplements of this vitamin.	Folic Acid	42-52	fuzzy planar cell polarity protein	Homo sapiens	132-135
10431526-7	1999	CONCLUSIONS: Greater efforts must be made to increase periconceptional use of folic acid for the prevention of NTD in pregnant women in Sicily.	Folic Acid	78-88	fuzzy planar cell polarity protein	Homo sapiens	111-114
10330863-9	1999	However, available evidence suggests low maternal folate status itself to be the major determinant of NTD risk.	Folic Acid	50-56	fuzzy planar cell polarity protein	Homo sapiens	102-105
10049741-2	1999	GTP cyclohydrolase I controls the de novo biosynthetic pathway of tetrahydrobiopterin and folic acid.	Folic Acid	90-100	GTP cyclohydrolase I	Saccharomyces cerevisiae S288C	0-20
10049741-4	1999	We show that the GTP cyclohydrolase I, encoded either by the E. coli folE gene or by the human cDNA, complements the yeast fol2Delta mutation by restoring folate prototrophy.	Folic Acid	155-161	GTP cyclohydrolase I	Saccharomyces cerevisiae S288C	17-37
10094554-1	1999	FRAXA, FRAXE, and FRAXF are folate-sensitive fragile sites originally discovered in patients with X-linked mental retardation.	Folic Acid	28-34	fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)	Homo sapiens	0-5
9973541-5	1999	In this article, we review the fundamental embryological processes involved in closing the neural tube, the relevant epidemiologic data on folic acid supplementation and relative NTD risk, as well as several recent studies of candidate genes for NTD sensitivity that are involved in folate transport and metabolism.	Folic Acid	283-289	fuzzy planar cell polarity protein	Homo sapiens	246-249
9674907-0	1998	Low blood folates in NTD pregnancies are only partly explained by thermolabile 5,10-methylenetetrahydrofolate reductase: low folate status alone may be the critical factor.	Folic Acid	10-17	fuzzy planar cell polarity protein	Homo sapiens	21-24
9674907-0	1998	Low blood folates in NTD pregnancies are only partly explained by thermolabile 5,10-methylenetetrahydrofolate reductase: low folate status alone may be the critical factor.	Folic Acid	10-16	fuzzy planar cell polarity protein	Homo sapiens	21-24
9674907-9	1998	The data suggest that low maternal folate status is itself the major determinant of NTD risk, or else that other folate-dependent genetic variants confer risk through the reduction of folate levels.	Folic Acid	35-41	fuzzy planar cell polarity protein	Homo sapiens	84-87
11177297-0	2000	In vitro effects of folic acid on gamma-glutamyltransferase and glutathione reductase activities in malignant lung and thymus tumors.	Folic Acid	20-30	glutathione-disulfide reductase	Homo sapiens	64-85
11177297-1	2000	In vitro effects of folic acid (10(-5), 10(-4), and 10(-3)M) on activities of gamma-glutamyltransferase and glutathione reductase, the enzymes involved in glutathione metabolism, were studied in tissue samples obtained after surgical treatment of the lungs and thymus.	Folic Acid	20-30	glutathione-disulfide reductase	Homo sapiens	108-129
11177297-4	2000	Activation of glutathione reductase was probably related to binding of folic acid in the allosteric center of the enzyme, which probably induced conformational changes in the catalytic center, acceleration of electron transport from NADPH(2) to oxidized glutathione via flavin adenine nucleotide, and intense production of reduced glutathione.	Folic Acid	71-81	glutathione-disulfide reductase	Homo sapiens	14-35
11504493-6	1999	Folate-based thymidylate synthase inhibitors may also be more effective in tumors with a high TP because of increased degradation of endogenous thymidine.	Folic Acid	0-6	thymidine phosphorylase	Homo sapiens	94-96
9843910-2	1998	Kid-1 mRNA levels increase in the course of postnatal renal development and decrease after acute renal injury caused by ischemia or administration of folic acid.	Folic Acid	150-160	zinc finger protein 354A	Rattus norvegicus	0-5
9791067-1	1998	Folate binding protein may participate in folate homeostasis by regulating monoglutamyl folate transport across relevant cell membranes.	Folic Acid	42-48	folate receptor 1	Sus scrofa	0-22
9791067-7	1998	Thus folate binding protein participates in folate homeostasis by regulating uptake by renal tubular membranes and uniquely by pig liver plasma membranes, but it is not involved in jejunal folate absorption.	Folic Acid	44-50	folate receptor 1	Sus scrofa	5-27
9829496-7	1998	We found a significant inverse relationship between plasma homocyst(e)ine and folate concentrations in both CsA(+) (r=-0.243; P&lt;0.005) and CsA(-) (r=-0.396; P&lt;0.05) patients.	Folic Acid	78-84	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	108-111
9829496-7	1998	We found a significant inverse relationship between plasma homocyst(e)ine and folate concentrations in both CsA(+) (r=-0.243; P&lt;0.005) and CsA(-) (r=-0.396; P&lt;0.05) patients.	Folic Acid	78-84	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	142-145
9582553-6	1998	Moreover, we found a significant inverse relationship between plasma homocyst(e)ine and folic acid concentrations in both CsA(+) (r = 0.218; p &lt; 0.01) and CsA(-) (r = -0.678; p &lt; 0.05) patients.	Folic Acid	88-98	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	158-161
9582553-3	1998	A recent study suggested that cyclosporine (CsA) increased plasma homocyst(e)ine concentration in interfering with folate-assisted remethylation of homocysteine.	Folic Acid	115-121	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	44-47
9582553-6	1998	Moreover, we found a significant inverse relationship between plasma homocyst(e)ine and folic acid concentrations in both CsA(+) (r = 0.218; p &lt; 0.01) and CsA(-) (r = -0.678; p &lt; 0.05) patients.	Folic Acid	88-98	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	122-125
9582553-10	1998	We demonstrated that as in other patient category, plasma folic acid and homocyst(e)ine concentrations are significantly correlated in CsA(+) patients.	Folic Acid	58-68	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	135-138
9499431-1	1998	The FRA3B at 3p14.2 is the most highly expressed of the common fragile sites observed when DNA replication is perturbed by aphidicolin or folate stress.	Folic Acid	138-144	fragile histidine triad diadenosine triphosphatase	Homo sapiens	4-9
9611072-4	1998	In an attempt to identify additional folate related enzymes that contribute to NTD etiology we now studied the methylenetetrahydrofolate dehydrogenase gene on chromosome 14q24 which encodes a single protein with three catalytic properties important in the folate metabolism.	Folic Acid	37-43	fuzzy planar cell polarity protein	Homo sapiens	79-82
9611072-4	1998	In an attempt to identify additional folate related enzymes that contribute to NTD etiology we now studied the methylenetetrahydrofolate dehydrogenase gene on chromosome 14q24 which encodes a single protein with three catalytic properties important in the folate metabolism.	Folic Acid	130-136	fuzzy planar cell polarity protein	Homo sapiens	79-82
9196356-5	1997	A decreased fat intake was associated with an increased sugar intake, but also with increased nutrient densities of thiamin, niacin, folate, vitamin C, magnesium, and iron, reflecting an increased intake of fruit, vegetables, and grains.	Folic Acid	133-139	FAT atypical cadherin 1	Homo sapiens	12-15
9041240-5	1997	Xenopus oocytes injected with hIFC-1 cRNA show induced folate uptake that was (1) saturable with substrate concentration (apparent Michaelis constant = 0.71 +/- 0.06 micromol/L; maximum velocity = 128 +/- 3 fmol x h(-1) x oocyte(-1)), (2) inhibited by methotrexate, folinic acid, and folic acid (Ki = 0.84 micromol/L, 0.71 micromol/L, and 10 micromol/L, respectively), and (3) sensitive to 4,4"-diisothiocyanostilbene-2,2"-disulfonic acid (Ki = 0.29 mmol/L).	Folic Acid	55-61	solute carrier family 19 member 1	Homo sapiens	30-36
9041240-5	1997	Xenopus oocytes injected with hIFC-1 cRNA show induced folate uptake that was (1) saturable with substrate concentration (apparent Michaelis constant = 0.71 +/- 0.06 micromol/L; maximum velocity = 128 +/- 3 fmol x h(-1) x oocyte(-1)), (2) inhibited by methotrexate, folinic acid, and folic acid (Ki = 0.84 micromol/L, 0.71 micromol/L, and 10 micromol/L, respectively), and (3) sensitive to 4,4"-diisothiocyanostilbene-2,2"-disulfonic acid (Ki = 0.29 mmol/L).	Folic Acid	284-294	solute carrier family 19 member 1	Homo sapiens	30-36
9037252-1	1997	A human reduced folate carrier (hRFC) cDNA was transfected into transport-deficient K562 cells to circumvent complications that may result from carrier expression in a heterologous mammalian species.	Folic Acid	16-22	solute carrier family 19 member 1	Homo sapiens	32-36
8920973-5	1996	Although defining the molecular structure of pig liver FBP, these studies suggest that this protein participates in the regulation of folate uptake by liver and kidney membranes but is not involved in folate absorption.	Folic Acid	134-140	folate receptor 1	Sus scrofa	55-58
8826441-5	1996	These preliminary data suggest that the 677C--&gt;T polymorphism of the MTHFR gene is a risk factor for spina bifida and anencephaly that may provide a partial biologic explanation for why folic acid prevents these types of NTD.	Folic Acid	189-199	fuzzy planar cell polarity protein	Homo sapiens	224-227
8651274-1	1996	The folate-sensitive fragile site FRAXE is located in proximal Xq28 of the human X chromosome and lies approximately 600 kb distal to the fragile X syndrome (FRAXA) fragile site at Xq27.3.	Folic Acid	4-10	fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)	Homo sapiens	158-163
8673085-1	1996	Five folate-sensitive fragile sites have been characterized at the molecular level (FRAXA, FRAXE, FRAXF, FRA16A and FRA11B).	Folic Acid	5-11	fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)	Homo sapiens	84-89
8824874-1	1996	The common fragile site at 3p14.2 (FRA3B) is the most sensitive site on normal human chromosomes for the formation of gaps and breaks when DNA replication is perturbed by aphidicolin or folate stress.	Folic Acid	186-192	fragile histidine triad diadenosine triphosphatase	Homo sapiens	35-40
8573145-1	1996	GTP-cyclohydrolase I is the first enzyme in the biosynthetic pathway leading to folic acid and tetrahydrobiopterin.	Folic Acid	80-90	GTP cyclohydrolase I	Saccharomyces cerevisiae S288C	0-20
7500985-7	1995	In analysis of controls, hprt MF increased with age and was inversely associated with intake of folate and vitamins A and C. The presence of lung cancer was not associated with hprt MF.	Folic Acid	96-102	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	25-29
8527095-3	1995	DESIGN AND METHODS: We constructed a chimeric protein between Tat and dihydrofolate reductase (DHFR), a cytosolic enzyme that binds tightly to the folate analogue methotrexate (MTX).	Folic Acid	77-83	tyrosine aminotransferase	Homo sapiens	62-65
7806217-2	1994	The common fragile site at 3p14.2 (FRA3B) is the most sensitive site on normal human chromosomes to breakage when DNA replication is perturbed by aphidicolin or folate stress.	Folic Acid	161-167	fragile histidine triad diadenosine triphosphatase	Homo sapiens	35-40
8382778-4	1993	Kid-1 mRNA levels decline after renal injury secondary to ischemia or folic acid administration, two insults which result in epithelial cell dedifferentiation, followed by regenerative hyperplasia and differentiation.	Folic Acid	70-80	zinc finger protein 354A	Rattus norvegicus	0-5
8440739-3	1993	Dihydrofolate reductase (DHFR) from hamster cells bore a low or poor affinity to these DAP as compared to the hydrophilic folate antagonist methotrexate (MTX).	Folic Acid	7-13	dihydrofolate reductase	Cricetulus griseus	25-29
1553748-2	1992	Furthermore, it has been reported that a polyglutamated folate derivative may serve as a coenzyme for the catalytic action of hepatic uroporphyrinogen III cosynthase.	Folic Acid	56-62	uroporphyrinogen III synthase	Rattus norvegicus	134-165
1656497-10	1991	Addition of folate also repressed the filamentation induced by cAMP at 43 degrees C in the fic-1 mutant.	Folic Acid	12-18	Fic	Escherichia coli	91-94
1656497-11	1991	These results would indicate that Fic protein and cAMP are involved in a new regulatory mechanism of cell division via folate metabolism.	Folic Acid	119-125	Fic	Escherichia coli	34-37
2327983-10	1990	These results indicate that the intestinal folate-binding and transport proteins are identical and that the function of the folate-binding protein is to transport folate into the cell.	Folic Acid	43-49	folate receptor 1	Sus scrofa	124-146
34864452-0	2022	Folic acid oversupplementation during pregnancy disorders lipid metabolism in male offspring via regulating arginase 1-associated NOS3-AMPKalpha pathway.	Folic Acid	0-10	arginase 1	Rattus norvegicus	108-118
34864452-10	2022	CONCLUSIONS: Our data suggest that maternal folic acid oversupplementation during pregnancy contributes to lipid metabolism disorder in male offspring by regulating Arg1-NOS3-AMPKalpha pathway.	Folic Acid	44-54	arginase 1	Rattus norvegicus	165-169
34155537-14	2022	CONCLUSIONS: In summary, we reported a proof-of-concept study of an albumin-binding folate derivative for macrophage imaging.	Folic Acid	84-90	albumin	Mus musculus	68-75
34831280-5	2021	STAT6 is activated in the kidney with folic acid nephropathy.	Folic Acid	38-48	signal transducer and activator of transcription 6	Mus musculus	0-5
34831280-6	2021	Compared with folic-acid-treated wild-type mice, STAT6 knockout mice had markedly reduced myeloid fibroblasts and myofibroblasts in the kidney with folic acid nephropathy.	Folic Acid	14-24	signal transducer and activator of transcription 6	Mus musculus	49-54
34831280-9	2021	Taken together, these results have shown that STAT6 plays a critical role in myeloid fibroblasts activation, M2 macrophage polarization, extracellular matrix protein production, and renal fibrosis development in folic acid nephropathy.	Folic Acid	212-222	signal transducer and activator of transcription 6	Mus musculus	46-51
34805133-1	2021	Mechanistic Target of Rapamycin Complex 2 (mTORC2) regulates placental amino acid and folate transport.	Folic Acid	86-92	CREB regulated transcription coactivator 2	Mus musculus	43-49
34769063-3	2021	In this study, we found that folate antagonists, such as methotrexate (MTX) and pemetrexed, are selectively cytotoxic to GSCs, but not to their differentiated counterparts, normal fibroblasts, or neural stem cells in vitro, and that the high sensitivity of GCSs to anti-folates may be due to the increased expression of RFC-1/SLC19A1, the reduced folate carrier that transports MTX into cells, in GSCs.	Folic Acid	29-35	solute carrier family 19 member 1	Homo sapiens	326-333
34769063-3	2021	In this study, we found that folate antagonists, such as methotrexate (MTX) and pemetrexed, are selectively cytotoxic to GSCs, but not to their differentiated counterparts, normal fibroblasts, or neural stem cells in vitro, and that the high sensitivity of GCSs to anti-folates may be due to the increased expression of RFC-1/SLC19A1, the reduced folate carrier that transports MTX into cells, in GSCs.	Folic Acid	270-277	solute carrier family 19 member 1	Homo sapiens	326-333
34769063-3	2021	In this study, we found that folate antagonists, such as methotrexate (MTX) and pemetrexed, are selectively cytotoxic to GSCs, but not to their differentiated counterparts, normal fibroblasts, or neural stem cells in vitro, and that the high sensitivity of GCSs to anti-folates may be due to the increased expression of RFC-1/SLC19A1, the reduced folate carrier that transports MTX into cells, in GSCs.	Folic Acid	347-353	solute carrier family 19 member 1	Homo sapiens	326-333
34666844-0	2021	Altered dietary ratio of folic acid and vitamin B12 during pregnancy influences the expression of imprinted H19/IGF2 locus in C57BL/6 mice.	Folic Acid	25-35	H19, imprinted maternally expressed transcript	Mus musculus	108-111
34666844-2	2021	This study elucidated the effect of altered dietary ratio of folic acid and B12 on the regulation of H19/IGF2 locus in C57BL/6 mice.	Folic Acid	61-71	H19, imprinted maternally expressed transcript	Mus musculus	101-104
34666844-6	2021	H19 overexpression observed under dietary deficiency of folate combined with normal B12 (BNFD) was associated with an increased expression of miR-675 in maternal and fetal tissues.	Folic Acid	56-62	H19, imprinted maternally expressed transcript	Mus musculus	0-3
34666844-6	2021	H19 overexpression observed under dietary deficiency of folate combined with normal B12 (BNFD) was associated with an increased expression of miR-675 in maternal and fetal tissues.	Folic Acid	56-62	microRNA 675	Mus musculus	142-149
34666844-11	2021	Results suggest that the altered dietary ratio of folic acid and B12 affects the in-utero development of the fetus in association with altered epigenetic regulation of H19/IGF2 locus.	Folic Acid	50-60	H19, imprinted maternally expressed transcript	Mus musculus	168-171
34681027-2	2021	These disorders are named for FRAXA, the folate-sensitive fragile site that localizes with the CGG-repeat in individuals with FXS.	Folic Acid	41-47	fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)	Homo sapiens	30-35
34692767-0	2021	Folic Acid Alleviates High Glucose and Fat-Induced Pyroptosis via Inhibition of the Hippo Signal Pathway on H9C2 Cells.	Folic Acid	0-10	FAT atypical cadherin 1	Rattus norvegicus	39-42
34692767-12	2021	Folic acid alleviated HGF-induced cell damage in vitro and in vivo by decreasing activation of the Hippo pathway, as indicated by lower LDH release and increased cell viability, and decreased expression of NLRP3, ASC, cleaved caspase-1, IL-1beta, IL-18, p-YAP and p-LATS.	Folic Acid	0-10	steroid sulfatase	Mus musculus	213-216
34692767-12	2021	Folic acid alleviated HGF-induced cell damage in vitro and in vivo by decreasing activation of the Hippo pathway, as indicated by lower LDH release and increased cell viability, and decreased expression of NLRP3, ASC, cleaved caspase-1, IL-1beta, IL-18, p-YAP and p-LATS.	Folic Acid	0-10	caspase 1	Mus musculus	226-235
34692767-12	2021	Folic acid alleviated HGF-induced cell damage in vitro and in vivo by decreasing activation of the Hippo pathway, as indicated by lower LDH release and increased cell viability, and decreased expression of NLRP3, ASC, cleaved caspase-1, IL-1beta, IL-18, p-YAP and p-LATS.	Folic Acid	0-10	interleukin 18	Mus musculus	247-252
34692767-12	2021	Folic acid alleviated HGF-induced cell damage in vitro and in vivo by decreasing activation of the Hippo pathway, as indicated by lower LDH release and increased cell viability, and decreased expression of NLRP3, ASC, cleaved caspase-1, IL-1beta, IL-18, p-YAP and p-LATS.	Folic Acid	0-10	yes-associated protein 1	Mus musculus	256-259
34692767-13	2021	Verteporfin or YAP1 siRNA neutralized the protective effect of folic acid by reversing YAP1-induced pyroptosis.	Folic Acid	63-73	yes-associated protein 1	Mus musculus	15-19
34692767-13	2021	Verteporfin or YAP1 siRNA neutralized the protective effect of folic acid by reversing YAP1-induced pyroptosis.	Folic Acid	63-73	yes-associated protein 1	Mus musculus	87-91
34147638-2	2021	MMACHC encodes an enzyme crucial for intracellular vitamin B12 metabolism, leading to the accumulation of toxic metabolites e.g. methylmalonic acid (MMA) and homocysteine (Hcy), and secondary disturbances in folate and one-carbon metabolism when not fully functional.	Folic Acid	208-214	methylmalonic aciduria cblC type, with homocystinuria	Mus musculus	0-6
34474604-7	2021	Meanwhile, folic acid deficiency decreased Cav-1 expression in the testis tissue and increased endoplasmic reticulum stress-related PERK, eIF2alpha, ATF4, CHOP gene expression.	Folic Acid	11-21	eukaryotic translation initiation factor 2A	Mus musculus	138-147
34418235-5	2022	RESULTS: Ultraviolet radiation (UVR) and pigmentation genes interact to modify blood vitamin levels; Light skin IRF4-TT genotype has greatest folate loss while light skin HERC2-GG genotype has greatest vitamin D3 synthesis (reflected in both TOMS and seasonal data).	Folic Acid	142-148	interferon regulatory factor 4	Homo sapiens	112-116
34418235-6	2022	UV-wavelength exhibits a dose-response relationship in folate loss within light skin IRF4-TT genotype (305 > 310 > 324 > 380 nm).	Folic Acid	55-61	interferon regulatory factor 4	Homo sapiens	85-89
34418235-11	2022	Lightest IRF4-TT/darkest HERC2-AA genotype combination (greatest folate loss/lowest vitamin D3 synthesis) has 0% occurrence.	Folic Acid	65-71	interferon regulatory factor 4	Homo sapiens	9-13
34418235-11	2022	Lightest IRF4-TT/darkest HERC2-AA genotype combination (greatest folate loss/lowest vitamin D3 synthesis) has 0% occurrence.	Folic Acid	65-71	HECT and RLD domain containing E3 ubiquitin protein ligase 2	Homo sapiens	25-30
34418235-12	2022	The opposing, commonest (39%) compound genotype (darkest IRF4-CC/lightest HERC2-GG) permits least folate loss and greatest synthesis of vitamin D3 .	Folic Acid	98-104	interferon regulatory factor 4	Homo sapiens	57-61
34418235-12	2022	The opposing, commonest (39%) compound genotype (darkest IRF4-CC/lightest HERC2-GG) permits least folate loss and greatest synthesis of vitamin D3 .	Folic Acid	98-104	HECT and RLD domain containing E3 ubiquitin protein ligase 2	Homo sapiens	74-79
34290703-8	2021	Results: BALB/c mice injected with PGA developed histopathology of SpA-like axial lesions, including spondylitis, sacroiliac joint arthritis and hip joint arthritis.	Folic Acid	35-38	surfactant associated protein A1	Mus musculus	67-70
34356833-0	2021	Chronic Kidney Disease Induced by Cisplatin, Folic Acid and Renal Ischemia Reperfusion Induces Anemia and Promotes GATA-2 Activation in Mice.	Folic Acid	45-55	GATA binding protein 2	Mus musculus	115-121
34093861-10	2021	Conclusions: Based on the results, we proposed a potential pathway for HGF or TGF-beta1-induced EMT of HCC cells: HGF or TGF-beta1 treatment of HCC cells can increase the expression of glycosyltransferase FUT8 to up-regulate the core-fucosylation of N-glycans on glycoproteins including the FOLR1; core-fucosylation on FOLR1 can then enhance the folate uptake capacity to finally promote the EMT progress of HCC cells.	Folic Acid	346-352	hepatocyte growth factor	Homo sapiens	71-74
35578055-5	2022	The study identified bentiamine, folic acid, benfotiamine, and vitamin B12 against the RBD of S protein and bentiamine, folic acid, fursultiamine, and riboflavin to 3CLpro.	Folic Acid	33-43	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	94-95
35565057-11	2022	CMap-CTD database analyses indicated the expression levels of Tlr2, Ccl2, Cxcl10, Fas, Irf8, Socs3, Stat3, Gbp6, Casp1 and Syk could be reversed by folic acid.	Folic Acid	148-158	suppressor of cytokine signaling 3	Homo sapiens	93-98
35285613-3	2022	Herein, we report two bi-functional AuNR-protein nanoconjugates, AuNR@EGFP-BSAFA and AuNR@RNaseA-BSAFA, supramolecularly coated with folic acid-modified BSA (BSAFA) acting as biomimetic protein corona to demonstrate targeted cytosolic delivery of enhanced green fluorescent protein (EGFP) and therapeutic ribonuclease A enzyme (RNase A) in their functional forms.	Folic Acid	133-143	ribonuclease A family member 1, pancreatic	Homo sapiens	328-335
35418433-10	2022	CONCLUSIONS: Racial/ethnic differences and different serum ferritin or serum folate levels may be effect modifiers for the association of VD-Hp CagA+.	Folic Acid	77-83	S100 calcium binding protein A8	Homo sapiens	144-148
35417465-0	2022	The regulation of HBP1, SIRT1, and SREBP-1c genes and the related microRNAs in non-alcoholic fatty liver rats: The association with the folic acid anti-steatosis.	Folic Acid	136-146	sterol regulatory element binding transcription factor 1	Rattus norvegicus	35-43
35417465-3	2022	Our current work aimd to explore the possible ameliorative potency of folic acid and its association with the hepatic miR-21, -34a, and -122 expression as well as their targeted genes, HBP1, SIRT1, and SREBP-1c in rats with non-alcoholic fatty liver disease (NAFL).	Folic Acid	70-80	sterol regulatory element binding transcription factor 1	Rattus norvegicus	202-210
35417465-11	2022	In conclusions, the anti-steatotic, insulin-sensitizing, glucose-lowering and lipotropic potencies of folic acid in NAFL rats may be linked to the epigenetic modulation of the hepatic microRNAs (miR-21, -34a, and -122) and the expression of their target genes (HBP1, SIRT1, and SREBP-1c).	Folic Acid	102-112	sterol regulatory element binding transcription factor 1	Rattus norvegicus	278-286
10522785-4	1999	Both the magnitude and duration of the specific IgM responses in these calves were increased by pre-treatment with PGA.	Folic Acid	115-118	IgM	Bos taurus	48-51
10522785-5	1999	In addition, the fourth infected calf tested gave a single positive IgM result following PGA treatment.	Folic Acid	89-92	IgM	Bos taurus	68-71
10522785-6	1999	Transient or persistent IgM responses which were abolished by pre-treatment of sera with PGA were detected in 4/8 calves following reinfection.	Folic Acid	89-92	IgM	Bos taurus	24-27
10522785-8	1999	One of these calves and two additional calves showed transient increases in IgM which were resistant to PGA treatment.	Folic Acid	104-107	IgM	Bos taurus	76-79
10090889-8	1999	These results favor a biological model of MTHFR-related NTD pathogenesis in which suboptimal maternal folate status imposes biochemical stress on the developing embryo, a stress it is ill-equipped to tolerate if it has a TT genotype.	Folic Acid	102-108	fuzzy planar cell polarity protein	Homo sapiens	56-59
9611019-4	1998	METHODS OF STUDY SELECTION: Articles were selected on the basis of their relevance to the relationship between folate intake and NTD incidence, mechanisms of folate responsive NTD formation, and folate provision strategy.	Folic Acid	111-117	fuzzy planar cell polarity protein	Homo sapiens	129-132
9611019-4	1998	METHODS OF STUDY SELECTION: Articles were selected on the basis of their relevance to the relationship between folate intake and NTD incidence, mechanisms of folate responsive NTD formation, and folate provision strategy.	Folic Acid	158-164	fuzzy planar cell polarity protein	Homo sapiens	176-179
9611019-4	1998	METHODS OF STUDY SELECTION: Articles were selected on the basis of their relevance to the relationship between folate intake and NTD incidence, mechanisms of folate responsive NTD formation, and folate provision strategy.	Folic Acid	158-164	fuzzy planar cell polarity protein	Homo sapiens	176-179
10222796-1	1999	The folate sensitive fragile site FRAXE is located in Xq28, 600 kb distal to the fragile X syndrome (FRAXA) fragile site.	Folic Acid	4-10	fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)	Homo sapiens	101-106
9426700-11	1998	In contrast, the inhibition of RFC by NHS-MTX, under conditions that did not affect FR-alpha functionality, generally reduced folate accumulation by more than 70%.	Folic Acid	126-132	solute carrier family 19 member 1	Homo sapiens	31-34
10100715-2	1999	Potential mechanisms of resistance include decreased transport through the reduced folate carrier (RFC) and increased expression of dihydrofolate reductase (DHFR).	Folic Acid	83-89	solute carrier family 19 member 1	Homo sapiens	99-102
9598063-10	1998	Cleland-type kinetic inhibition experiments indicate that the AICARFT reaction is of the ordered, sequential type with the reduced folate cofactor binding first.	Folic Acid	131-137	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	62-69
9679969-3	1998	In a representative experiment, raising the folic acid concentration in the medium dramatically increased the Loewe synergy for the combination of trimetrexate (TMTX) and the GARFT inhibitor AG2034 (from a mean alpha +/- SE of 1.50 +/- 0.25 at 2.3 microM folic acid to 146 +/- 20 at 78 microM folic acid).	Folic Acid	44-54	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	Homo sapiens	175-180
9598063-16	1998	A PurH crystal structure is that of a dimer, with a putative single binding site for the reduced folate cofactor formed using elements from each of the monomer subunits.	Folic Acid	97-103	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	2-6
9649607-5	1998	The folate depletion also resulted in an increased ratio of dUTP/dTTP in mitogen-stimulated lymphocyte DNA and decreased lymphocyte NAD, changes suggesting misincorporation of uracil into DNA and increased DNA repair activity.	Folic Acid	4-10	ttp	Drosophila melanogaster	65-69
9458739-2	1998	The open reading frame of this clone is identical to that of the reduced folate carrier (RFC) (K. H. Dixon, B. C. Lanpher, J. Chiu, K. Kelley, and K. H. Cowan.	Folic Acid	73-79	solute carrier family 19 (folate transporter), member 1 L homeolog	Xenopus laevis	89-92
9458739-6	1998	The characteristics of this cDNA clone [previously referred to as intestinal folate carrier 1 (IFC-1)] expressed in Xenopus oocytes, however, were found to be different from the characteristics of folate transport in native small intestinal epithelial cells.	Folic Acid	77-83	solute carrier family 19 (folate transporter), member 1 L homeolog	Xenopus laevis	95-100
9458739-10	1998	Similarly, uptake of folic acid and 5-methyltetrahydrofolate (5-MTHF) by IEC-6/RFC was found to be fourfold higher than uptake in control sublines.	Folic Acid	21-31	solute carrier family 19 (folate transporter), member 1 L homeolog	Xenopus laevis	79-82
9458739-11	1998	This increase in folic acid and 5-MTHF uptake was inhibited by treating IEC-6/RFC cells with cholesterol-modified antisense DNA oligonucleotides.	Folic Acid	17-27	solute carrier family 19 (folate transporter), member 1 L homeolog	Xenopus laevis	78-81
9458739-13	1998	In both IEC-6/RFC and control sublines, the uptake of both folic acid and 5-MTHF displayed 1) pH dependency, with a higher uptake at acidic pH 5.5 compared with pH 7.5, and 2) inhibition to the same extent by both reduced and oxidized folate derivatives.	Folic Acid	59-69	solute carrier family 19 (folate transporter), member 1 L homeolog	Xenopus laevis	14-17
9458739-15	1998	In contrast, RFC expressed in Xenopus oocytes showed 1) higher uptake at neutral and alkaline pH 7.5 compared with acidic pH 5.5 and 2) higher sensitivity to reduced compared with oxidized folate derivatives.	Folic Acid	189-195	solute carrier family 19 (folate transporter), member 1 L homeolog	Xenopus laevis	13-16
9384610-2	1998	Most patients have a mutation in the 5" untranslated region of the FMR1 gene, consisting of the amplification of a polymorphic (CGG)nrepeat sequence, and cytogenetically express the folate-sensitive fragile site FRAXA in Xq27.3.	Folic Acid	182-188	fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)	Homo sapiens	212-217
9310238-8	1997	These results display the power of confocal microscopy for directly visualizing RFC-mediated anti-folate uptake.	Folic Acid	98-104	solute carrier family 19 member 1	Homo sapiens	80-83
9188676-0	1997	NTD phenotypes in infants and fetuses whose mothers used multivitamins containing folic acid in early pregnancy compared to those who did not.	Folic Acid	82-92	fuzzy planar cell polarity protein	Homo sapiens	0-3
24234672-4	1996	The NSGC further urges the Food and Drug Administration to fortify staple foodstuffs with folic acid for a population-based approach to minimize the number of NTD births.	Folic Acid	90-100	fuzzy planar cell polarity protein	Homo sapiens	159-162
9208415-9	1997	The previously acquired folate depletion could affect normal appositional function of myelin basic protein molecules due to insufficient methylation of arginine in position 107.	Folic Acid	24-30	myelin basic protein	Homo sapiens	86-106
8918933-1	1996	The rare folate-sensitive, fragile sites on chromsomes X, 11, and 16 contain blocks of CCG triplet repeats and large expansions of the CCG block at the FRAXA site produce the fragile X syndrome (FraX).	Folic Acid	9-15	fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)	Homo sapiens	152-157
8691264-1	1996	UNLABELLED: Folate binding protein (FBP) GP38 is a membrane-associated glycoprotein that mediates the intracellular transport of folates.	Folic Acid	129-136	podoplanin	Homo sapiens	41-45
7763286-0	1995	Structural preferences among folate compounds and their analogues for ATPase-mediated efflux by inside-out plasma membrane vesicles derived from L1210 cells.	Folic Acid	29-35	dynein, axonemal, heavy chain 8	Mus musculus	70-76
7763286-2	1995	In the current studies, we examined by competitive inhibition with [3H]MTX as permeant some of the structural features that determine preferences among folate compounds and their analogues as permeants for this ATPase.	Folic Acid	152-158	dynein, axonemal, heavy chain 8	Mus musculus	211-217
7766710-1	1995	We present evidence for the presence of the folate metabolism enzyme methenyltetrahydrofolate synthetase (MTHFS) in mitochondria.	Folic Acid	44-50	methenyltetrahydrofolate synthetase	Homo sapiens	69-104
7766710-1	1995	We present evidence for the presence of the folate metabolism enzyme methenyltetrahydrofolate synthetase (MTHFS) in mitochondria.	Folic Acid	44-50	methenyltetrahydrofolate synthetase	Homo sapiens	106-111
7766710-6	1995	Intracellular tetrahydrofolate metabolism is highly compartmentalized and mitochondrial MTHFS activity is necessary for the entry of mitochondrial 5-formyltetrahydrofolate into the mitochondrial folate pool.	Folic Acid	24-30	methenyltetrahydrofolate synthetase	Homo sapiens	88-93
7990714-0	1994	Folate-mediated incorporation of ring-2-carbon of histidine into nucleic acids: influence of thyroid hormone.	Folic Acid	0-6	ring finger protein 2	Homo sapiens	33-39
7990714-1	1994	Folate-mediated incorporation of [ring-2-14C]histidine into DNA and its modulation under thyroid stress have been studied.	Folic Acid	0-6	ring finger protein 2	Homo sapiens	34-40
7874164-1	1994	Three folate-sensitive fragile sites, termed FRAXA, FRAXE and FRAXF, have been identified on the distal end of chromosome Xq.	Folic Acid	6-12	fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)	Homo sapiens	45-50
8185668-8	1994	In addition, alcohol ingestion was associated with longer glutamate chains of the folate molecules, characterized by lower relative concentrations of pentaglutamyl folates (29 vs 48%), and higher relative concentrations of hexa- and heptaglutamyl folates (55 vs 46% and 15 vs 6%) when compared with controls.	Folic Acid	82-88	hexosaminidase subunit alpha	Rattus norvegicus	223-227
8490650-1	1993	The vast majority of patients with fragile X syndrome show a folate-sensitive fragile site at Xq27.3 (FRAXA) at the cytogenetic level, and both amplification of the (CGG)n repeat and hypermethylation of the CpG island in the 5" fragile X gene (FMR-1) at the molecular level.	Folic Acid	61-67	fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)	Homo sapiens	102-107
1415487-1	1992	Vimentin expression was studied immunohistochemically in renal cortical tubules of untreated male rats of various ages, rats exposed to toxins (barbital sodium, folic acid) and carcinogens (streptozotocin, N-bis(2-hydroxypropyl)nitrosamine, barbital sodium, and in humans of various ages with or without renal epithelial tumors.	Folic Acid	161-171	vimentin	Rattus norvegicus	0-8
1329737-1	1992	The renal expressions of the receptor gene (c-met) for hepatocyte growth factor (HGF) were examined in unilateral nephrectomy (UNX), renal ischemia or folic acid administration.	Folic Acid	151-161	MET proto-oncogene, receptor tyrosine kinase	Rattus norvegicus	44-49
1397183-1	1992	Pteroyl polyglutamate hydrolase (folyl conjugase), which hydrolyses the dietary polyglutamyl folates into simple forms prior to absorption, has been shown to be induced in rat pancreas in response to dietary polyglutamyl folates but not by ingestion of synthetic unconjugated folates.	Folic Acid	93-100	gamma-glutamyl hydrolase	Rattus norvegicus	39-48
1397183-4	1992	These results taken together would suggest that dietary folates are hydrolysed to monoglutamyl forms suitable for absorption in the lumen; the hydrolysis is catalysed by a luminal folyl conjugase of pancreatic origin induced by dietary conjugated folates.	Folic Acid	56-63	gamma-glutamyl hydrolase	Rattus norvegicus	186-195
1397183-4	1992	These results taken together would suggest that dietary folates are hydrolysed to monoglutamyl forms suitable for absorption in the lumen; the hydrolysis is catalysed by a luminal folyl conjugase of pancreatic origin induced by dietary conjugated folates.	Folic Acid	247-254	gamma-glutamyl hydrolase	Rattus norvegicus	186-195
1600953-10	1992	These results confirm the importance of age and, less so, cigarette smoking as factors that influence mutant frequency and suggest that a micronutrient, folic acid, may modify genetic damage at the hprt locus.	Folic Acid	153-163	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	198-202
10387998-3	1996	Methenyltetrahydrofolate synthetase (MTHFS) catalyzes the transformation of 5-formyltetrahydrofolate to methenylH(4)folate, which is the obligatory initial metabolic step prior to the intracellular conversion of 5-formylH(4)folate to other reduced folates and the increase in intracellular folate pools required for 5-FU potentiation.	Folic Acid	248-255	methenyltetrahydrofolate synthetase	Homo sapiens	0-35
10387998-3	1996	Methenyltetrahydrofolate synthetase (MTHFS) catalyzes the transformation of 5-formyltetrahydrofolate to methenylH(4)folate, which is the obligatory initial metabolic step prior to the intracellular conversion of 5-formylH(4)folate to other reduced folates and the increase in intracellular folate pools required for 5-FU potentiation.	Folic Acid	248-255	methenyltetrahydrofolate synthetase	Homo sapiens	37-42
10387998-3	1996	Methenyltetrahydrofolate synthetase (MTHFS) catalyzes the transformation of 5-formyltetrahydrofolate to methenylH(4)folate, which is the obligatory initial metabolic step prior to the intracellular conversion of 5-formylH(4)folate to other reduced folates and the increase in intracellular folate pools required for 5-FU potentiation.	Folic Acid	18-24	methenyltetrahydrofolate synthetase	Homo sapiens	37-42
2069475-1	1991	The occurrence of increased levels of blood phenylalanine after therapeutic administration of folate analogues has been occasionally reported and attributed to the inhibition of dihydropteridine reductase, an enzyme maintaining the cofactor of phenylalanine hydroxylase in its active tetrahydrogenated form (tetrahydrobiopterin).	Folic Acid	94-100	phenylalanine hydroxylase	Homo sapiens	244-269
8820949-3	1996	Methenyltetrahydrofolate synthetase (MTHFS) catalyzes the transformation of 5-formyl-tetrahydrofolate to methenylH4folate, which is the obligatory initial metabolic step prior to the intracellular conversion of 5-formylH4folate to other reduced folates and the increase in intracellular folate pools required for 5-FU potentiation.	Folic Acid	245-252	methenyltetrahydrofolate synthetase	Homo sapiens	0-35
8820949-3	1996	Methenyltetrahydrofolate synthetase (MTHFS) catalyzes the transformation of 5-formyl-tetrahydrofolate to methenylH4folate, which is the obligatory initial metabolic step prior to the intracellular conversion of 5-formylH4folate to other reduced folates and the increase in intracellular folate pools required for 5-FU potentiation.	Folic Acid	245-252	methenyltetrahydrofolate synthetase	Homo sapiens	37-42
8820949-3	1996	Methenyltetrahydrofolate synthetase (MTHFS) catalyzes the transformation of 5-formyl-tetrahydrofolate to methenylH4folate, which is the obligatory initial metabolic step prior to the intracellular conversion of 5-formylH4folate to other reduced folates and the increase in intracellular folate pools required for 5-FU potentiation.	Folic Acid	18-24	methenyltetrahydrofolate synthetase	Homo sapiens	37-42
2242072-3	1990	In the present study, we showed that the inhibition of IL-1 activity in vitro by MTX is dependent on folate pathways since, after the addition of leucovorin, the inhibitory effect of MTX was abolished.	Folic Acid	101-107	interleukin 1 complex	Mus musculus	55-59
8522195-1	1995	Methenyltetrahydrofolate synthetase (MTHFS) catalyses the obligatory initial metabolic step in the intracellular conversion of 5-formyltetrahydrofolate to other reduced folates.	Folic Acid	169-176	methenyltetrahydrofolate synthetase	Homo sapiens	0-35
8522195-1	1995	Methenyltetrahydrofolate synthetase (MTHFS) catalyses the obligatory initial metabolic step in the intracellular conversion of 5-formyltetrahydrofolate to other reduced folates.	Folic Acid	169-176	methenyltetrahydrofolate synthetase	Homo sapiens	37-42
33797937-10	2021	Positive associations of second-trimester PM2.5 with SBP and DBP percentiles were stronger in children with maternal folate concentrations in the lowest quartile (pinteraction= 0.05 and 0.07, respectively) and associations with DBP percentiles were stronger in female children (pinteraction= 0.05).	Folic Acid	117-123	selenium binding protein 1	Homo sapiens	53-56
8276792-1	1994	Mammalian cells accumulate reduced folates and methotrexate, a folate antagonist, through the reduced-folate carrier (RFC) (Goldman, I.D., Lichtenstein, N.S., and Oliverio, V.T.	Folic Acid	35-42	solute carrier family 19 member 1	Homo sapiens	94-122
8276792-1	1994	Mammalian cells accumulate reduced folates and methotrexate, a folate antagonist, through the reduced-folate carrier (RFC) (Goldman, I.D., Lichtenstein, N.S., and Oliverio, V.T.	Folic Acid	35-41	solute carrier family 19 member 1	Homo sapiens	94-122
34940957-10	2022	During most time periods adjusted mean changes in CDAI, mHAQ, and PGA scores and the proportion of patients achieving a clinical response were significantly higher for ACPA+ versus ACPA- patients initiating abatacept.	Folic Acid	66-69	proteinase 3	Homo sapiens	168-172
8221478-7	1993	A recent multicentre randomized controlled trial showed that among women at high risk of having a child with an NTD those who received 4 mg/d of folic acid had 72% fewer cases of NTD-affected offspring than nonsupplemented women.	Folic Acid	145-155	fuzzy planar cell polarity protein	Homo sapiens	112-115
8221478-7	1993	A recent multicentre randomized controlled trial showed that among women at high risk of having a child with an NTD those who received 4 mg/d of folic acid had 72% fewer cases of NTD-affected offspring than nonsupplemented women.	Folic Acid	145-155	fuzzy planar cell polarity protein	Homo sapiens	179-182
8221478-8	1993	Two previous intervention studies also demonstrated that folic acid supplementation was effective in reducing the rate of NTD recurrence.	Folic Acid	57-67	fuzzy planar cell polarity protein	Homo sapiens	122-125
34957089-3	2021	MTRR is necessary for methyl group utilisation from folate metabolism, and the Mtrr gt allele disrupts this process.	Folic Acid	52-58	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Mus musculus	0-4
1379942-1	1992	Polyglutamate analogs of folate and related compounds were tested as inhibitors of casein kinase II (CK II) obtained from Xenopus laevis.	Folic Acid	25-31	casein kinase 2, alpha 1 polypeptide S homeolog	Xenopus laevis	83-99
34957089-3	2021	MTRR is necessary for methyl group utilisation from folate metabolism, and the Mtrr gt allele disrupts this process.	Folic Acid	52-58	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Mus musculus	79-83
34319204-3	2021	Here, we describe a high-efficiency gene delivery strategy by using miR-34a-mimic loaded folate modified microbubbles (miR-34a-FM) with a portable ultrasonic irradiation system.	Folic Acid	89-95	microRNA 34a	Homo sapiens	68-75
1619631-8	1992	A further two families had consistent expression of a different folate sensitive fragile site, FRAXE, close to FRAXA but not associated with fragile X syndrome and not detectable with the pfxa3 probe.	Folic Acid	64-70	fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)	Homo sapiens	111-116
34319204-3	2021	Here, we describe a high-efficiency gene delivery strategy by using miR-34a-mimic loaded folate modified microbubbles (miR-34a-FM) with a portable ultrasonic irradiation system.	Folic Acid	89-95	microRNA 34a	Homo sapiens	119-126
1631781-1	1992	Dihydrofolate reductase reduces folic acid to tetrahydrofolate as a prerequisite to one-carbon metabolism, which is required for normal embryonic de novo DNA synthesis.	Folic Acid	32-42	dihydrofolate reductase	Oryctolagus cuniculus	0-23
34331261-1	2021	The main aim of this research was to design a MCL-1 siRNA and dexamethasone (DEX)-loaded folate modified poly(lactide-co-glycolide) (PLGA)-based polymeric micelles with an eventual goal to improve the therapeutic outcome in the rheumatoid arthritis (RA).	Folic Acid	89-95	myeloid cell leukemia sequence 1	Mus musculus	46-51
1894617-6	1991	Southern blot analysis of the low folate-adapted cell line revealed that, while neither of the two FBP-encoding genes was amplified, the FBP1 genomic locus had undergone rearrangement.	Folic Acid	34-40	fructose bisphosphatase 1	Mus musculus	137-141
1904273-1	1991	A fluorescein derivative of the lysine analogue of folic acid, N alpha-pteroyl-N epilson-(4"-fluoresceinthiocarbamoyl)-L-lysine (PLF), was synthesized as a probe for dihydrofolate reductase (DHFR) and a membrane folate binding protein (m-FBP).	Folic Acid	51-61	PLF	Homo sapiens	129-132
2242072-5	1990	They also point to the fact that some IL-1 activities may be dependent on intracellular folate pathways.	Folic Acid	88-94	interleukin 1 complex	Mus musculus	38-42
2124130-3	1990	Drosophila melanogaster DHFR can use folate and NADH at acidic pH values, but at a much lower rate than the preferred substrate and cofactor.	Folic Acid	37-43	Dihydrofolate reductase	Drosophila melanogaster	24-28
34331261-4	2021	Folate-conjugated DEX/siRNA-loaded polymeric micelles (DS-FPM) significantly lowered the MCL-1 mRNA expression compared to either DEX/siRNA-loaded polymeric micelles (DS-PM) or free siRNA in Raw264.7 cells and macrophage cells suggesting the importance of targeted nanocarriers.	Folic Acid	0-6	myeloid cell leukemia sequence 1	Mus musculus	89-94
2124130-4	1990	Folic acid is a partial competitive inhibitor of Drosophila DHFR (Ki = 0.4 microM) and trimethoprim is a complete competitive inhibitor (Ki = 5.4 microM).	Folic Acid	0-10	Dihydrofolate reductase	Drosophila melanogaster	60-64
34533844-3	2021	Methylenetetrahydrofolate dehydrogenase 1 like (MTHFD1L), a metabolic enzyme of the folate cycle regulating the production of formate, was identified as a downstream target of melatonin.	Folic Acid	84-90	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like	Homo sapiens	48-55
34917229-0	2021	Folic Acid Protects Melanocytes from Oxidative Stress via Activation of Nrf2 and Inhibition of HMGB1.	Folic Acid	0-10	high mobility group box 1	Homo sapiens	95-100
34293696-6	2021	Gene expression of folate carriers (Folr1, Slc19a1, Slc46a1) and metabolizing enzymes (Cth, Mtr, Mtrr, Mthfr, Dhfr) was assessed in the placenta on gestational day (GD) 13 or GD20.	Folic Acid	19-25	solute carrier family 46 member 1	Rattus norvegicus	52-59
34358572-7	2021	TNF-alpha-treated mice presented increased p38MAPK phosphorylation and decreased Akt phosphorylation, and the later effect was prevented by folic acid (10 mg/kg, p.o.).	Folic Acid	140-150	mitogen-activated protein kinase 14	Mus musculus	43-50
34358572-8	2021	Additionally, ERK1 phosphorylation was increased in mice treated with TNF-alpha + folic acid (1 mg/kg), but no effects on ERK2 or JNK1/2/3 phosphorylation were found in any group.	Folic Acid	82-92	mitogen-activated protein kinase 3	Mus musculus	14-18
34604366-15	2021	Finally, contents of LPL, PPARgamma, and FAS in abdominal fat were decreased with the folic acid supplmented diets (P < 0.01).	Folic Acid	86-96	lipoprotein lipase	Gallus gallus	21-24
34604366-15	2021	Finally, contents of LPL, PPARgamma, and FAS in abdominal fat were decreased with the folic acid supplmented diets (P < 0.01).	Folic Acid	86-96	peroxisome proliferator-activated receptor gamma	Gallus gallus	26-35
34567068-8	2021	The folate-sensitive FSs include FRAXA that is associated with Fragile X syndrome (FXS), the most common heritable form of intellectual disability.	Folic Acid	4-10	fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)	Homo sapiens	33-38
34567068-10	2021	Recent work suggests that both APH-inducible fragile sites and FRAXA undergo Mitotic DNA synthesis (MiDAS) when exposed to APH or folate stress, respectively.	Folic Acid	130-136	fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)	Homo sapiens	63-68
34160104-6	2021	We found increased numbers of S100A4 positive cells expressing PKM2 in renal tissues from mice with AKI induced via folic acid or ischemia/reperfusion (I/R).	Folic Acid	116-126	pyruvate kinase, muscle	Mus musculus	63-67
34160104-9	2021	Moreover, in two AKI mouse models, fibroblast-specific deletion of PKM2 blocked HGF signal activation and aggravated AKI after it was induced in mice via ischemia or folic acid.	Folic Acid	166-176	pyruvate kinase, muscle	Mus musculus	67-71
34140513-0	2021	Defective folate metabolism causes germline epigenetic instability and distinguishes Hira as a phenotype inheritance biomarker.	Folic Acid	10-16	histone cell cycle regulator	Mus musculus	85-89
34140513-2	2021	We previously showed that disruption of folate metabolism in mice by the Mtrr hypomorphic mutation results in transgenerational epigenetic inheritance of congenital malformations.	Folic Acid	40-46	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Mus musculus	73-77
34204335-3	2021	OBJECTIVE: To determine if maternal dietary intake of folic acid (FA) is related to the methylation status (MS) of VSD-associated genes (AXIN1, MTHFR, TBX1, and TBX20).	Folic Acid	54-64	T-box transcription factor 1	Homo sapiens	151-155
34204335-3	2021	OBJECTIVE: To determine if maternal dietary intake of folic acid (FA) is related to the methylation status (MS) of VSD-associated genes (AXIN1, MTHFR, TBX1, and TBX20).	Folic Acid	54-64	T-box transcription factor 20	Homo sapiens	161-166
34093861-10	2021	Conclusions: Based on the results, we proposed a potential pathway for HGF or TGF-beta1-induced EMT of HCC cells: HGF or TGF-beta1 treatment of HCC cells can increase the expression of glycosyltransferase FUT8 to up-regulate the core-fucosylation of N-glycans on glycoproteins including the FOLR1; core-fucosylation on FOLR1 can then enhance the folate uptake capacity to finally promote the EMT progress of HCC cells.	Folic Acid	346-352	hepatocyte growth factor	Homo sapiens	114-117
34093861-10	2021	Conclusions: Based on the results, we proposed a potential pathway for HGF or TGF-beta1-induced EMT of HCC cells: HGF or TGF-beta1 treatment of HCC cells can increase the expression of glycosyltransferase FUT8 to up-regulate the core-fucosylation of N-glycans on glycoproteins including the FOLR1; core-fucosylation on FOLR1 can then enhance the folate uptake capacity to finally promote the EMT progress of HCC cells.	Folic Acid	346-352	fucosyltransferase 8	Homo sapiens	205-209
35349697-7	2022	K50 de-acetylation destabilizes MTHFD2 by elevating Cullin 3 (CUL3) E3 ligase-mediated proteasomal degradation in response to stressful stimuli of folate deprivation, leading to suppression of nicotinamide adenine dinucleotide phosphate (NADPH) production in tumor cells and accumulation of intracellular reactive oxygen species (ROS), which in turn inhibits the growth of breast cancer cells.	Folic Acid	147-153	cullin 3	Homo sapiens	52-60
35349697-7	2022	K50 de-acetylation destabilizes MTHFD2 by elevating Cullin 3 (CUL3) E3 ligase-mediated proteasomal degradation in response to stressful stimuli of folate deprivation, leading to suppression of nicotinamide adenine dinucleotide phosphate (NADPH) production in tumor cells and accumulation of intracellular reactive oxygen species (ROS), which in turn inhibits the growth of breast cancer cells.	Folic Acid	147-153	cullin 3	Homo sapiens	62-66
2557328-5	1989	In addition, virtually all of the folate binding sites on the plasma membrane of the intact cells were released as soluble, functional FBP following treatment with PI-PLC.	Folic Acid	34-40	phospholipase C beta 1	Homo sapiens	164-170
2807044-4	1989	During pyridoxine and folate treatment, antithrombin III activity rapidly returned to normal; factor VII increased and beta-thromboglobulin decreased.	Folic Acid	22-28	pro-platelet basic protein	Homo sapiens	119-139
3674417-4	1987	For the analyses of rat liver folates, 20 ml of clear supernatant obtained from 5 g of tissue was treated with conjugase, which released folate monoglutamates from endogenous stores.	Folic Acid	30-37	gamma-glutamyl hydrolase	Rattus norvegicus	111-120
6825117-2	1983	The amount of the renal O6-methylguanine-DNA methyltransferase was increased up to 2.5-fold during renal hypertrophy in response to unilateral nephrectomy or treatment with folic acid.	Folic Acid	173-183	O-6-methylguanine-DNA methyltransferase	Rattus norvegicus	24-62
34845393-5	2021	The liver, in contrast, derives acetyl-CoA for lipogenesis from acetate and lactate, and NADPH from folate-mediated serine catabolism.	Folic Acid	100-106	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	89-94
34845393-8	2021	Thus, liver folate metabolism is distinctively wired to support cytosolic NADPH production and lipogenesis.	Folic Acid	12-18	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	74-79
7074014-2	1982	We identified the one-carbon units present in rat liver folates within each of the liver folate polyglutamate groups, the folate penta-, hexa-, and heptaglutamates.	Folic Acid	56-63	hexosaminidase subunit alpha	Rattus norvegicus	137-141
34560414-2	2021	In this study, we designed a folate-grafted PEI600-CyD (H1) nanoparticle-mediated DNA vaccine containing an adjuvant of high mobility group box 1 protein (HMGB1) and a tumor-specific antigen of B7H3 (CD276) for renal carcinoma therapy.	Folic Acid	29-35	cytochrome b-245, beta polypeptide	Mus musculus	51-54
34560414-2	2021	In this study, we designed a folate-grafted PEI600-CyD (H1) nanoparticle-mediated DNA vaccine containing an adjuvant of high mobility group box 1 protein (HMGB1) and a tumor-specific antigen of B7H3 (CD276) for renal carcinoma therapy.	Folic Acid	29-35	high mobility group box 1	Mus musculus	120-153
34560414-2	2021	In this study, we designed a folate-grafted PEI600-CyD (H1) nanoparticle-mediated DNA vaccine containing an adjuvant of high mobility group box 1 protein (HMGB1) and a tumor-specific antigen of B7H3 (CD276) for renal carcinoma therapy.	Folic Acid	29-35	high mobility group box 1	Mus musculus	155-160
6894161-0	1981	Properties of folic acid gamma-glutamyl hydrolase (conjugase) in rat bile and plasma.	Folic Acid	14-24	gamma-glutamyl hydrolase	Rattus norvegicus	25-49
34762361-13	2021	Nonetheless, treatment with folic acid, either singly or when combined with L-citrulline, increases NO production and inhibits PH in chronically hypoxic newborn piglets.	Folic Acid	28-38	phenylalanine hydroxylase	Homo sapiens	127-129
34762361-14	2021	Folic acid merits consideration as a therapy for PH in human infants with chronic heart and lung conditions that are associated with chronic hypoxia.	Folic Acid	0-10	phenylalanine hydroxylase	Homo sapiens	49-51
6894161-0	1981	Properties of folic acid gamma-glutamyl hydrolase (conjugase) in rat bile and plasma.	Folic Acid	14-24	gamma-glutamyl hydrolase	Rattus norvegicus	51-60
6894161-1	1981	The properties of folic acid gamma-glutamyl hydrolase (conjugase) [EC 3.4.12.10] in rat bile and plasma were investigated.	Folic Acid	18-28	gamma-glutamyl hydrolase	Rattus norvegicus	29-53
6894161-1	1981	The properties of folic acid gamma-glutamyl hydrolase (conjugase) [EC 3.4.12.10] in rat bile and plasma were investigated.	Folic Acid	18-28	gamma-glutamyl hydrolase	Rattus norvegicus	55-64
265135-6	1977	Iron and folate deficiency each suppressed Hb A2 levels in beta-thalassemia heterozygotes; however, vitamin B12 deficiency did not alter the percentage of Hb A2 in thalassemia.	Folic Acid	9-15	hemoglobin subunit alpha 2	Homo sapiens	43-48
34352110-6	2021	Two of the interactions, one with the folate biosynthetic enzyme DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE 1 (AtDHFR-TS1) and another with nitrogen metabolism-associated glutamine synthetase 1;4 (AtGLN1;4), were further characterized.	Folic Acid	38-44	glutamine synthetase 1;4	Arabidopsis thaliana	199-207
34474856-0	2021	Folate targeted hybrid lipo-polymeric nanoplexes containing docetaxel and miRNA-34a for breast cancer treatment.	Folic Acid	0-6	microRNA 34a	Homo sapiens	74-83
1255268-4	1976	In subcellular fractionation studies, folate conjugase was minimally present in the brush border relative to the supernatant fraction.	Folic Acid	38-44	gamma-glutamyl hydrolase	Rattus norvegicus	45-54
34474856-2	2021	The present work reports folate targeted hybrid lipo-polymeric nanoplexes for co-delivering DTX and miR-34a.	Folic Acid	25-31	microRNA 34a	Homo sapiens	100-107
34330444-5	2021	Herein, a nanobiosensor for detecting sodium and potassium ions using folic acid-functionalised reduced graphene oxide-modified RNase A gold nanoclusters (FA-rGO-RNase A/AuNCs) based on fluorescence "turn-off/turn-on" is presented.	Folic Acid	70-80	ribonuclease A family member 1, pancreatic	Homo sapiens	128-135
1168985-1	1975	Recent observations have indicated that uterine folic acid conjugase (pterolypolyglutamyl hydrolase) undergoes rhythmic variation during the reproductive cycle of the rat.	Folic Acid	48-58	gamma-glutamyl hydrolase	Rattus norvegicus	59-68
34330444-5	2021	Herein, a nanobiosensor for detecting sodium and potassium ions using folic acid-functionalised reduced graphene oxide-modified RNase A gold nanoclusters (FA-rGO-RNase A/AuNCs) based on fluorescence "turn-off/turn-on" is presented.	Folic Acid	70-80	ribonuclease A family member 1, pancreatic	Homo sapiens	162-169
34512669-8	2021	Unilateral ureteral obstruction or folic acid administration induced STAT6 activation in interstitial cells of the kidney, which was significantly abolished by AS1517499 treatment.	Folic Acid	35-45	signal transducer and activator of transcription 6	Mus musculus	69-74
5856245-0	1965	[5-nucleotidase in the prenatal life of the rat deprived of folic acid].	Folic Acid	60-70	5' nucleotidase, ecto	Rattus norvegicus	0-15
14844270-0	1951	Beneficial effects of vitamin B12 and folic acid on recovery from internal radiation by P32.	Folic Acid	38-48	inhibitor of growth family member 2	Homo sapiens	88-91
34401965-10	2021	The calculation of vibrational frequencies shows that the presence of folic acid intermediate reduces the vibrational frequency of the hydroxyl group (OH) so that its absorption energy (Ead) is equal to the lowest value 65.24 a.u.	Folic Acid	70-80	collagen like tail subunit of asymmetric acetylcholinesterase	Homo sapiens	186-189
34330116-0	2021	Activating Caspase-8/Bid/ROS Signaling to Promote Apoptosis of Breast Cancer Cells by Folate-modified Albumin Baicalin-loaded Nanoparticles.	Folic Acid	86-92	caspase 8	Homo sapiens	11-20
33400181-8	2021	Our bioinformatics analysis revealed that the oxidative stress genes superoxide dismutase (SOD1, SOD2) and the pro-inflammatory marker tumor necrosis factor (TNF) were identified as the top relevant genes, and the folate metabolism, vitamin B12 metabolism, and the ALS pathways were highly affected by formaldehyde and related to the most brain diseases of interest.	Folic Acid	214-220	superoxide dismutase 2	Homo sapiens	97-101
34104654-6	2021	Since folate is required for the generation and maintenance of T reg , we propose that one mechanism for microbiome-based control of AD/AID is via folate-dependent induction of GI tract T reg , particularly colonic T reg, via anergic T cells (T an).	Folic Acid	6-12	activation induced cytidine deaminase	Homo sapiens	136-139
34104654-6	2021	Since folate is required for the generation and maintenance of T reg , we propose that one mechanism for microbiome-based control of AD/AID is via folate-dependent induction of GI tract T reg , particularly colonic T reg, via anergic T cells (T an).	Folic Acid	147-153	activation induced cytidine deaminase	Homo sapiens	136-139
34104654-7	2021	Hence, folate supplementation has potential prophylactic and/or therapeutic benefit in AID/AD.	Folic Acid	7-13	activation induced cytidine deaminase	Homo sapiens	87-90
34008284-0	2021	Different dietary combinations of folic acid and vitamin B12 in parental diet results in epigenetic reprogramming of IGF2R and KCNQ1OT1 in placenta and fetal tissues in mice.	Folic Acid	34-44	insulin-like growth factor 2 receptor	Mus musculus	117-122
35303537-3	2022	Three different systems control folate uptake in the human body; folate receptors function to capture and internalise extracellular folates via endocytosis, whereas two major facilitator superfamily transporters, the reduced folate carrier (RFC; SLC19A1) and proton-coupled folate transporter (PCFT; SLC46A1) control the transport of folates across cellular membranes.	Folic Acid	225-231	solute carrier family 19 member 1	Homo sapiens	246-253
35303537-3	2022	Three different systems control folate uptake in the human body; folate receptors function to capture and internalise extracellular folates via endocytosis, whereas two major facilitator superfamily transporters, the reduced folate carrier (RFC; SLC19A1) and proton-coupled folate transporter (PCFT; SLC46A1) control the transport of folates across cellular membranes.	Folic Acid	334-341	solute carrier family 19 member 1	Homo sapiens	246-253
34008284-6	2021	Dietary deficiency of folate (BNFD and BOFD) and B12 (BDFN) with either state of other vitamin or combined deficiency of both vitamins (BDFD) in comparison to BNFN, were overall responsible for reduced expression of IGF2R in the placenta (F1) and the fetal liver (F2) whereas a combination of folate deficiency with different levels of B12 revealed sex-specific differences in kidney and brain.	Folic Acid	22-28	insulin-like growth factor 2 receptor	Mus musculus	216-221
35589004-0	2022	Biosynthesis of folic acid appended PHBV modified copper oxide nanorods for pH sensitive drug release in targeted breast cancer therapy.	Folic Acid	16-26	phenylalanine hydroxylase	Homo sapiens	76-78
34008284-6	2021	Dietary deficiency of folate (BNFD and BOFD) and B12 (BDFN) with either state of other vitamin or combined deficiency of both vitamins (BDFD) in comparison to BNFN, were overall responsible for reduced expression of IGF2R in the placenta (F1) and the fetal liver (F2) whereas a combination of folate deficiency with different levels of B12 revealed sex-specific differences in kidney and brain.	Folic Acid	293-299	insulin-like growth factor 2 receptor	Mus musculus	216-221
34008284-7	2021	The alterations in the expression of IGF2R caused by folate-deficient conditions (BNFD and BOFD) and both deficient condition (BDFD) was found to be associated with an increase in suppressive histone modifications.	Folic Acid	53-59	insulin-like growth factor 2 receptor	Mus musculus	37-42
34008284-8	2021	Over-supplementation of either folate or B12 or both vitamins in comparison to BNFN, led to increase in expression of IGF2R and KCNQ1OT1 in the placenta and fetal tissues.	Folic Acid	31-37	insulin-like growth factor 2 receptor	Mus musculus	118-123
34008284-9	2021	The increase in the expression of IGF2R caused by folate over-supplementation (BNFO) was associated with decreased DNA methylation in fetal tissues.	Folic Acid	50-56	insulin-like growth factor 2 receptor	Mus musculus	34-39
35170934-3	2022	The film was functionalized by coating folic acid-conjugated CS on one side.	Folic Acid	39-49	citrate synthase	Homo sapiens	61-63
34008284-11	2021	An epigenetic reprograming of IGF2R and KCNQ1OT1 ncRNA in the offspring was evident upon different dietary combinations of folic acid and B12 in the mice.	Folic Acid	123-133	insulin-like growth factor 2 receptor	Mus musculus	30-35
34046500-7	2021	The release kinetics obtained is impressive, and once targeted to the cancerous sites, using cancer directing agents, such as folic acid; a glutamate urea ligand known as DUPA; aminopeptidase N, also known as CD13; and FAP-alpha-targeting agents, the slow release of the drug is expected to destroy only the cancerous cells.	Folic Acid	126-136	alanyl aminopeptidase, membrane	Homo sapiens	209-213
35157101-10	2022	CONCLUSION: SLC19A1 facilitates the import of cyclic dinucleotides and reduced folates, evaluating genotypes in this gene can help in better management of patients on methotrexate treatment.	Folic Acid	79-86	solute carrier family 19 member 1	Homo sapiens	12-19
34046500-7	2021	The release kinetics obtained is impressive, and once targeted to the cancerous sites, using cancer directing agents, such as folic acid; a glutamate urea ligand known as DUPA; aminopeptidase N, also known as CD13; and FAP-alpha-targeting agents, the slow release of the drug is expected to destroy only the cancerous cells.	Folic Acid	126-136	fibroblast activation protein alpha	Homo sapiens	219-228
33933170-8	2021	The altered expression of genes involved in mitochondrial translation and energy production also emerged, followed by the altered expression of genes encoding for the folate cycle enzyme, GART, and the folate transporter, SLC19A1.	Folic Acid	167-173	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	Homo sapiens	188-192
35268281-7	2022	However, the relationships between erythrocyte folate concentrations and the occurrence of alternative variants: c.665C>T MTHFR and c.776G>C TCN2, as well as the methylmalonic acid concentration and the occurrence of alternative variant c.776G>C TCN2 in pregnant women with fetal-T21, encourage further research.	Folic Acid	47-53	transcobalamin 2	Homo sapiens	141-145
33933170-8	2021	The altered expression of genes involved in mitochondrial translation and energy production also emerged, followed by the altered expression of genes encoding for the folate cycle enzyme, GART, and the folate transporter, SLC19A1.	Folic Acid	167-173	solute carrier family 19 member 1	Homo sapiens	222-229
3366769-3	1988	Chemically synthesized monoglutamated or pentaglutamated 10-formyl-H2folate was examined for its interaction with three folate-dependent enzymes: AICAR transformylase, glucinamide ribotide (GAR) transformylase, and thymidylatesynthase.	Folic Acid	69-75	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	146-151
33063250-2	2021	The aim of this study was to evaluate a new class of albumin-binding radioconjugates comprising 5-methyltetrahydrofolate (5-MTHF) as a targeting agent and to compare their properties with those of the previously established folic acid-based [177Lu]Lu-OxFol-1.	Folic Acid	224-234	albumin	Mus musculus	53-60
3793108-2	1986	A significantly increased frequency of FRA3B induced by G2 treatment of araC was found in the lymphocytes grown in folate-deficient medium (positive rate 100%).	Folic Acid	115-121	fragile histidine triad diadenosine triphosphatase	Homo sapiens	39-44
3793108-3	1986	A relatively low frequency of FRA3B was also induced in the cultures with folate in four of the seven subjects.	Folic Acid	74-80	fragile histidine triad diadenosine triphosphatase	Homo sapiens	30-35
33719535-12	2021	Conclusions: The study suggests that the folic acid-targeted cGAMP-loaded liposomes deliver drugs to the TME to enhance the STING agonist activity, improving the efficiency of tumor therapy via the cGAMP-STING-IRF3 pathway.	Folic Acid	41-51	interferon regulatory factor 3	Mus musculus	210-214
3793108-4	1986	There is a synergistic effect between araC and growth in folate-deficient medium on the induction of FRA3B.	Folic Acid	57-63	fragile histidine triad diadenosine triphosphatase	Homo sapiens	101-106
33086234-10	2021	Of 26 women who became pregnant on study before week 24, folate concentrations increased between baseline and 12 weeks by a mean 2.4 +- 7.1 nmol/L in the TAF/FTC+DTG arm and 2.3 +- 8.4 nmol/L in the TDF/FTC+DTG arm, but decreased by -3.3 +- 8.1 with TDF/FTC/EFV arm.	Folic Acid	57-63	TATA-box binding protein associated factor 8	Homo sapiens	154-157
2428470-10	1986	We conclude that polyglutamylation can alter the interaction of folate analogues and dihydrofolate with DHFR.	Folic Acid	64-70	dihydrofolate reductase	Ovis aries	104-108
33212346-2	2021	Towards this, the present work aims to develop and evaluate a radioactive technetium-99m (99mTc) labeled gold nanoparticle (NP) preparation modified with folic acid, so as to diagnose folate receptor positive cancers viz.	Folic Acid	154-164	biliverdin reductase B (flavin reductase (NADPH))	Mus musculus	184-199
6433972-1	1984	Degradation of 7,8-dihydrofolate (H2folate) in the presence of dihydrofolate reductase (DHFR) has been shown due not to an oxygenase activity of the reductase as previously reported but to dismutation of H2folate to folate and 5,6,7,8-tetrahydrofolate (H4folate).	Folic Acid	26-32	dihydrofolate reductase	Bos taurus	63-86
6433972-1	1984	Degradation of 7,8-dihydrofolate (H2folate) in the presence of dihydrofolate reductase (DHFR) has been shown due not to an oxygenase activity of the reductase as previously reported but to dismutation of H2folate to folate and 5,6,7,8-tetrahydrofolate (H4folate).	Folic Acid	26-32	dihydrofolate reductase	Bos taurus	88-92
33848540-0	2021	Pharmacological inhibition of SETD7 by PFI-2 attenuates renal fibrosis following folic acid and obstruction injury.	Folic Acid	81-91	SET domain containing (lysine methyltransferase) 7	Mus musculus	30-35
33848540-5	2021	Furthermore, SETD7 inhibition reduced the infiltration of inflammatory cells and decreased the production of pro-inflammatory cytokines and chemokines in the kidneys after folic acid treatment (P<0.01).	Folic Acid	172-182	SET domain containing (lysine methyltransferase) 7	Mus musculus	13-18
33848540-6	2021	Finally, SETD7 inhibition suppressed the accumulation of NF-kappaB p65+ cells in folic acid nephropathy (P<0.01).	Folic Acid	81-91	SET domain containing (lysine methyltransferase) 7	Mus musculus	9-14
34024154-11	2021	With factors as categorical variables, Lp(a) but not LDL-C negatively associated with elevated vitamin B12 (-5.41(-9.50, -1.53), p=0.01) and folate (-2.86(-5.09, -0.63), p=0.01).	Folic Acid	141-147	lipoprotein(a)	Homo sapiens	39-44
33212346-10	2021	Inhibition of [3H]folic acid with functionalized gold nanoparticle revealed affinity towards FR positive KB cell lines with an IC50 ~ 9 muM.	Folic Acid	18-28	biliverdin reductase B (flavin reductase (NADPH))	Mus musculus	93-95
33181482-9	2021	Combing with DEG, 14 couples of lncRNAs and their target genes were both DE, and 6 of them including CCDC39, KCNJ16, NECTIN2, MRPL20, PSMC4, and DEFB112 show their potential infertility-related terms such as cellular motility, sperm maturation, sperm storage, cellular junction, folate metabolism, and capacitation.	Folic Acid	279-285	nectin cell adhesion molecule 2	Bos taurus	117-124
33432521-2	2022	In this study, folate-targeted polymeric micellar carrier was successfully constructed to co-delivery of doxorubicin (DOX) and SIS3 (FA/DOX/SIS3 micelles), a specific Smad3 inhibitor which sensitizes ABCB1- and ABCG2-overexpressing cancer cells to chemotherapeutic agents.	Folic Acid	15-21	SMAD family member 3	Homo sapiens	167-172
34021639-0	2021	High Gestational Folic Acid Supplementation Prevents Hypoxia-Ischemia-Induced Caspase-3 Augmenting Without Changing Synapsin And H3 Methylation Levels In The Rat Hippocampus.	Folic Acid	17-27	caspase 3	Rattus norvegicus	78-87
33326752-4	2021	Tumor-specific reliance on cytosolic 1C flux is associated with poor capacity to retain intracellular folates, which is determined by the expression of SLC19A1, which encodes the reduced folate carrier (RFC).	Folic Acid	102-109	solute carrier family 19 member 1	Homo sapiens	152-159
33979572-4	2021	Studies investigating the mechanism revealed that PGA diminished the binding efficiency of ETS family of transcription factor (ELK1) and Serum response factor (SRF), and suppressed ELK1-SRF complex-dependent transcription, which decreased the transcriptional levels of downstream genes Early growth response protein 1 (EGR1)-Polycomb ring finger (BMI1), thus inducing the imbalanced regulation between Myeloid cell leukaemia-1 (MCL1) and F-Box and WD repeat domain containing 7 (FBXW7).	Folic Acid	50-53	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	347-351
33326752-4	2021	Tumor-specific reliance on cytosolic 1C flux is associated with poor capacity to retain intracellular folates, which is determined by the expression of SLC19A1, which encodes the reduced folate carrier (RFC).	Folic Acid	102-108	solute carrier family 19 member 1	Homo sapiens	152-159
33898872-0	2021	Non-viral vector mediated CKb11 with folic acid modification regulates macrophage polarization and DC maturation to elicit immune response against cancer.	Folic Acid	37-47	C-C motif chemokine ligand 19	Homo sapiens	26-31
32865889-7	2021	Moreover, the folate analogue methotrexate (MTX), used in combination with thiopurines during maintenance therapy of childhood leukaemia, affects the metabolism of thiopurines and interacts with TPMT, not only by binding and inhibiting the enzyme activity but also by regulation of its gene expression.	Folic Acid	14-20	thiopurine S-methyltransferase	Homo sapiens	195-199
33898872-3	2021	In this study, a folic acid (FA) -modified gene delivery system based on the self-assembly of DOTAP, MPEG-PCL-MPEG, and FA-PEG-PCL-PEG-FA, namely F-PPPD, was developed to deliver plasmids encoding the immunostimulating chemokine CKb11.	Folic Acid	17-27	C-C motif chemokine ligand 19	Homo sapiens	229-234
32749195-9	2021	A high expression of SFRP1 was observed in subjects with high BMI or high folate status (p < 0.05).	Folic Acid	74-80	secreted frizzled related protein 1	Homo sapiens	21-26
32403197-1	2020	WHAT IS KNOWN AND OBJECTIVE: Reduced folate carrier 1 (RFC1), which is encoded by the human solute carrier family 19 member 1 (SLC19A1) gene, plays an essential role in the cellular uptake of methotrexate (MTX).	Folic Acid	37-43	solute carrier family 19 member 1	Homo sapiens	92-125
33875081-4	2021	Macrophage-targeting cationic liposome modified by folate (FA-LP) was developed to deliver siIRF5 (FA-LP/siIRF5).	Folic Acid	51-57	melanocortin 2 receptor accessory protein	Mus musculus	59-64
32403197-1	2020	WHAT IS KNOWN AND OBJECTIVE: Reduced folate carrier 1 (RFC1), which is encoded by the human solute carrier family 19 member 1 (SLC19A1) gene, plays an essential role in the cellular uptake of methotrexate (MTX).	Folic Acid	37-43	solute carrier family 19 member 1	Homo sapiens	127-134
32720563-6	2021	The two de novo folate biosynthesis pathway enzymes, GTP cyclohydrolase I (GCH1) and 6-pyruvoyl tetrahydropterin synthase (PTPS), can provide an alternative strategy to overcome the drug resistance that emerged in the two primary targeted enzymes dihydrofolate reductase and dihydropteroate synthase.	Folic Acid	16-22	GTP cyclohydrolase 1	Homo sapiens	53-73
32963203-1	2021	Folic acid (FA), is a group B vitamin, has high reactive oxygen radicals quenching ability, resulting in protection against oxidative damage in aerobic cell.	Folic Acid	0-10	glycogen synthase kinase 3 beta	Rattus norvegicus	12-14
32720563-6	2021	The two de novo folate biosynthesis pathway enzymes, GTP cyclohydrolase I (GCH1) and 6-pyruvoyl tetrahydropterin synthase (PTPS), can provide an alternative strategy to overcome the drug resistance that emerged in the two primary targeted enzymes dihydrofolate reductase and dihydropteroate synthase.	Folic Acid	16-22	GTP cyclohydrolase 1	Homo sapiens	75-79
33288723-3	2020	Herein, using a xenograft mouse tumor model, it was demonstrated that microRNA miR-21-targeted micro-oligonucleotides administered in complex with folate-containing liposomes dramatically inhibit primary tumor growth via long-term down-regulation of miR-21 in tumors and increase in biosynthesis of miR-21-regulated tumor suppressor proteins.	Folic Acid	147-153	microRNA 21a	Mus musculus	250-256
32720563-6	2021	The two de novo folate biosynthesis pathway enzymes, GTP cyclohydrolase I (GCH1) and 6-pyruvoyl tetrahydropterin synthase (PTPS), can provide an alternative strategy to overcome the drug resistance that emerged in the two primary targeted enzymes dihydrofolate reductase and dihydropteroate synthase.	Folic Acid	16-22	6-pyruvoyltetrahydropterin synthase	Homo sapiens	85-121
33288723-3	2020	Herein, using a xenograft mouse tumor model, it was demonstrated that microRNA miR-21-targeted micro-oligonucleotides administered in complex with folate-containing liposomes dramatically inhibit primary tumor growth via long-term down-regulation of miR-21 in tumors and increase in biosynthesis of miR-21-regulated tumor suppressor proteins.	Folic Acid	147-153	microRNA 21a	Mus musculus	250-256
32826232-3	2020	We establish that folate restriction and deficiency of the rate-limiting folate cycle enzyme, MTHFR - which exhibits reduced-function polymorphisms in about 10% of Caucasians - induce resistance to MYC targeting by BET and CDK7 inhibitors in cell lines, primary patient samples, and syngeneic mouse models of AML.	Folic Acid	18-24	delta/notch like EGF repeat containing	Homo sapiens	215-218
32826232-3	2020	We establish that folate restriction and deficiency of the rate-limiting folate cycle enzyme, MTHFR - which exhibits reduced-function polymorphisms in about 10% of Caucasians - induce resistance to MYC targeting by BET and CDK7 inhibitors in cell lines, primary patient samples, and syngeneic mouse models of AML.	Folic Acid	73-79	delta/notch like EGF repeat containing	Homo sapiens	215-218
32456526-0	2020	MTHFD1L as a folate cycle enzyme correlates with prognostic outcome and its knockdown impairs cell invasive behaviors in osteosarcoma via mediating the AKT/mTOR pathway.	Folic Acid	13-19	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like	Homo sapiens	0-7
32720563-6	2021	The two de novo folate biosynthesis pathway enzymes, GTP cyclohydrolase I (GCH1) and 6-pyruvoyl tetrahydropterin synthase (PTPS), can provide an alternative strategy to overcome the drug resistance that emerged in the two primary targeted enzymes dihydrofolate reductase and dihydropteroate synthase.	Folic Acid	16-22	6-pyruvoyltetrahydropterin synthase	Homo sapiens	123-127
32765270-7	2020	One of them showed that folic acid inhibits the furin protease which the virus needs in order to enter its host cell, while the other one explained that folic acid inactivates protease 3CL pro , a protein that the virus needs to replicate.	Folic Acid	24-34	furin, paired basic amino acid cleaving enzyme	Homo sapiens	48-53
33294634-11	2020	General significance: Result explains that AgNPs are recommended as a valuable system in enhancing the industrial production of biologically active zDHFR protein which is an important component in folate cycle and essential for survival of cells and prevents the protein from being aggregated.	Folic Acid	197-203	dihydrofolate reductase	Danio rerio	148-153
32980406-10	2020	Results suggest that the cangrelor, fludarabine, folic acid and polydatin were the most potent drugs which had potency to inhibit both the wild type and mutant SARS-CoV-2 helicase.	Folic Acid	49-59	helicase for meiosis 1	Homo sapiens	171-179
33193126-13	2020	Based on the pathogen infection assay, tomato plants inoculated with cna1 or cnb1 mutant have a dramatic reduction in disease severity, indicating that calcineurin has a vital role in Fol virulence.	Folic Acid	184-187	CNA1	Homo sapiens	69-73
32726663-7	2020	So in this study, we intended to simultaneously suppress CD73 and CDKs in cancer cells by using the folic acid (FA)-conjugated chitosan-lactate (CL) NPs loaded with anti-CD73 siRNA and Dinaciclib to control tumor progression and metastasis.	Folic Acid	100-110	cyclin-dependent kinase 1	Mus musculus	66-70
31646387-0	2020	Modelling the impact of mandatory folic acid fortification of bread or flour in Ireland on the risk of occurrence of NTD-affected pregnancies in women of childbearing age and on risk of masking vitamin B12 deficiency in older adults.	Folic Acid	34-44	fuzzy planar cell polarity protein	Homo sapiens	117-120
31646387-3	2020	This study estimated the impact of addition of folic acid to bread or flour in the Republic of Ireland on reducing the risk of occurrence of NTD-affected pregnancies and the possible risk of masking (undiagnosed) vitamin B12 deficiency in older adults.	Folic Acid	47-57	fuzzy planar cell polarity protein	Homo sapiens	141-144
31646387-7	2020	RESULTS: The fortification scenarios examined would reduce the risk of NTD-affected pregnancies by 8-32%, corresponding to an increase of 39-152 mug in the mean daily folic acid intake of WCBA.	Folic Acid	167-177	fuzzy planar cell polarity protein	Homo sapiens	71-74
32820034-4	2021	Functional analysis indicates that CIC binds to an octameric sequence in the promoter regions of folate transport genes: FOLR1, PCFT and reduced folate carrier (Slc19A1; RFC1).	Folic Acid	97-103	solute carrier family 19 member 1	Homo sapiens	161-168
32820034-4	2021	Functional analysis indicates that CIC binds to an octameric sequence in the promoter regions of folate transport genes: FOLR1, PCFT and reduced folate carrier (Slc19A1; RFC1).	Folic Acid	145-151	solute carrier family 19 member 1	Homo sapiens	161-168
32241696-8	2020	Further study showed that folate and vitamin B6 might decrease the risk of estrogen receptor-negative (ER-)/progesterone receptor-negative (PR-) breast cancer but not ER+/PR+ breast cancer.	Folic Acid	26-32	progesterone receptor	Homo sapiens	108-129
32543769-10	2020	Together, these findings demonstrate that NRF-1/PGC-1alpha activation by PQQ upregulates RFC functional expression at the BBB and could potentially enhance brain folate uptake.	Folic Acid	162-168	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	48-58
32601218-9	2020	We propose that break-induced DNA replication is required for the replication of FRAXA under folate stress and define a cellular function for human SLX1.	Folic Acid	93-99	fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)	Homo sapiens	81-86
32630405-10	2020	Vitamin B12 also has a critical role in the metabolism as a coenzyme of the enzyme methionine synthase for the transfer of a methyl group from folic acid to homocysteine for the regeneration of methionine.	Folic Acid	143-153	5-methyltetrahydrofolate-homocysteine methyltransferase	Bos taurus	83-102
32384607-4	2020	We identified six genes (GART, PFAS, PPAT, PAICS, ATIC, and ADSL) whose blocking results in nearly the same effect in the metabolic network as folate depletion.	Folic Acid	143-149	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	Homo sapiens	25-29
32384607-4	2020	We identified six genes (GART, PFAS, PPAT, PAICS, ATIC, and ADSL) whose blocking results in nearly the same effect in the metabolic network as folate depletion.	Folic Acid	143-149	phosphoribosyl pyrophosphate amidotransferase	Homo sapiens	37-41
32384607-4	2020	We identified six genes (GART, PFAS, PPAT, PAICS, ATIC, and ADSL) whose blocking results in nearly the same effect in the metabolic network as folate depletion.	Folic Acid	143-149	phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase	Homo sapiens	43-48
32384607-4	2020	We identified six genes (GART, PFAS, PPAT, PAICS, ATIC, and ADSL) whose blocking results in nearly the same effect in the metabolic network as folate depletion.	Folic Acid	143-149	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	50-54
32384607-4	2020	We identified six genes (GART, PFAS, PPAT, PAICS, ATIC, and ADSL) whose blocking results in nearly the same effect in the metabolic network as folate depletion.	Folic Acid	143-149	adenylosuccinate lyase	Homo sapiens	60-64
31961264-0	2020	The sake yeast YHR032W/ERC1 allele contributes to the regulation of the tetrahydrofolate content in the folate synthetic pathway in sake yeast strains.	Folic Acid	82-88	Erc1p	Saccharomyces cerevisiae S288C	23-27
31961264-2	2020	The results revealed that the sake yeast ERC1 allele contributes to an increase in the ratio of THF to the total folate content in sake yeast.	Folic Acid	113-119	Erc1p	Saccharomyces cerevisiae S288C	41-45
32223781-1	2020	OBJECTIVE: There is limited evidence on the interaction by alcohol dehydrogenase 2 (ADH1B) (rs1229984) and aldehyde dehydrogenase 2 (ALDH2) (rs671) regarding the associations of alcohol and a methyl diet (low folate and high alcohol intake) with cancer risk, partly because of rare polymorphisms in Western populations.	Folic Acid	209-215	aldehyde dehydrogenase 2 family member	Homo sapiens	133-138
32257815-4	2020	MTRR enzyme is a key regulator of the methionine and folate cycles.	Folic Acid	53-59	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Mus musculus	0-4
31693171-5	2020	Key Results CBD activity is partially dependent upon the mitochondrial glycine cleavage system component, GcvH1 in Dictyostelium, orthologous to the human GCSH protein, which is functionally linked to folate one-carbon metabolism (FOCM).	Folic Acid	201-218	glycine cleavage system protein H	Homo sapiens	155-159
32051732-0	2020	Pretreatment with Roxadustat (FG-4592) Attenuates Folic Acid-Induced Kidney Injury through Antiferroptosis via Akt/GSK-3beta/Nrf2 Pathway.	Folic Acid	50-60	glycogen synthase kinase 3 alpha	Mus musculus	115-124
32800270-14	2020	AHRR is also a smoking biomarker due to changed methylation sites found in smokers DNA although folate intake may partially revert these methylation alterations.	Folic Acid	96-102	aryl hydrocarbon receptor repressor	Homo sapiens	0-4
32800270-15	2020	This corroborates the role of maternal smoking and lack of folate supplementation as risk factors for CL/P.	Folic Acid	59-65	cysteine and glycine rich protein 3	Homo sapiens	102-106
31713293-1	2020	OBJECTIVE: To assess the association between polymorphic variants from SHMT1 and MTHFS genes, involved in the cytoplasmic futile folate cycle, and the risk of nonsyndromic cleft lip with or without cleft palate (NSCL/P) in the Chilean population.	Folic Acid	129-135	methenyltetrahydrofolate synthetase	Homo sapiens	81-86
31722724-5	2019	We demonstrated that an increase in H2AK119ub1 downregulated expression of the neural tube closure-related genes Cdx2, Nes, Pax6, and Gata4 in mouse embryonic stem cells under folate deficiency conditions.	Folic Acid	176-182	caudal type homeobox 2	Mus musculus	113-117
31722724-5	2019	We demonstrated that an increase in H2AK119ub1 downregulated expression of the neural tube closure-related genes Cdx2, Nes, Pax6, and Gata4 in mouse embryonic stem cells under folate deficiency conditions.	Folic Acid	176-182	nestin	Mus musculus	119-122
31111486-0	2019	Association between the BHMT gene rs3733890 polymorphism and the efficacy of oral folate therapy in patients with hyperhomocysteinemia.	Folic Acid	82-88	betaine--homocysteine S-methyltransferase	Homo sapiens	24-28
31111486-3	2019	We investigated the association between the BHMT rs3733890 and the efficacy of oral folate therapy for HHcy in the Chinese Han population and analysed the effects of gene-environmental interactions on the efficacy.	Folic Acid	84-90	betaine--homocysteine S-methyltransferase	Homo sapiens	44-48
31683806-4	2019	Here, the size and shape dependent mechanism of a functionalized copolymer was investigated using folic acid (FA) covalently bonded to the copolymer poly (styrene-alt-maleic anhydride) (SMA) on its hydrophilic exterior via a biological linker 2,4-diaminobutyric acid (DABA) to target folic acid receptors (FR) overly expressed on cancer cells actively.	Folic Acid	98-108	survival of motor neuron 1, telomeric	Homo sapiens	186-189
31683806-4	2019	Here, the size and shape dependent mechanism of a functionalized copolymer was investigated using folic acid (FA) covalently bonded to the copolymer poly (styrene-alt-maleic anhydride) (SMA) on its hydrophilic exterior via a biological linker 2,4-diaminobutyric acid (DABA) to target folic acid receptors (FR) overly expressed on cancer cells actively.	Folic Acid	284-294	survival of motor neuron 1, telomeric	Homo sapiens	186-189
35582405-4	2022	In this study, a novel FR-directed, macropinocytosis-enhanced, and highly cytotoxic bioconjugate folate (F)-human serum albumin (HSA)-apoprotein of lidamycin (LDP)-active enediyne (AE) derived from lidamycin was designed and prepared.	Folic Acid	97-103	albumin	Mus musculus	114-157
35061292-6	2022	Recently, cryo-electron microscopy structures of chicken PCFT in a substrate-free state and in complex with the antifolate pemetrexed were reported, providing further structural insights into determinants of (anti)folate recognition and the mechanism of pH-regulated (anti)folate transport by PCFT.	Folic Acid	214-220	solute carrier family 46 member 1	Gallus gallus	57-61
35061292-6	2022	Recently, cryo-electron microscopy structures of chicken PCFT in a substrate-free state and in complex with the antifolate pemetrexed were reported, providing further structural insights into determinants of (anti)folate recognition and the mechanism of pH-regulated (anti)folate transport by PCFT.	Folic Acid	273-279	solute carrier family 46 member 1	Gallus gallus	57-61
35058790-0	2021	circHIPK3 Exacerbates Folic Acid-Induced Renal Tubulointerstitial Fibrosis by Sponging miR-30a.	Folic Acid	22-32	microRNA 30a	Homo sapiens	87-94
34973132-2	2022	Indeed, we have developed biodegradable nanoparticles (NPs) of poly(ethylene glycol)-poly(epsilon-caprolactone), exposing on the surface both folate motifs (Fol) for recognition in cells overexpressing Folate receptor-alpha (FRalpha) and the anti-angiogenic hexapeptide aFLT1.	Folic Acid	142-148	laminin, alpha 5	Danio rerio	225-232
2714776-6	1989	Of six different folate-sensitive ARFS detected, the most common one was FRA9A, with a frequency of 1 in 241 individuals.	Folic Acid	17-23	fragile site, folic acid type, rare, fra(9)(p21)	Homo sapiens	73-78
3681903-2	1987	We have studied the effect of HU on the common fragile site at 3p14 (FRA3B) and have found that G2 treatment with HU increased not only the frequency of chromosomal aberration but also the expression of FRA3B in both complete and folate deficient media.	Folic Acid	230-236	fragile histidine triad diadenosine triphosphatase	Homo sapiens	203-208
3681903-3	1987	There is a synergistic effect between HU and growth in folate deficient medium on the induction of FRA3B.	Folic Acid	55-61	fragile histidine triad diadenosine triphosphatase	Homo sapiens	99-104
3839013-1	1985	Folate conjugase, an intestinal enzyme that hydrolyzes dietary polyglutamyl folate to the absorbable monoglutamyl derivative, is present in two locations in human jejunal mucosa: one on the brush border membrane, the other soluble and intracellar.	Folic Acid	0-6	gamma-glutamyl hydrolase	Rattus norvegicus	7-16
3839013-4	1985	In both the human and pig, brush border folate conjugase was active from pH 4.5 to 8.5, and activity was significantly increased by zinc acetate.	Folic Acid	40-46	gamma-glutamyl hydrolase	Rattus norvegicus	47-56
3839013-5	1985	In contrast, folate conjugase activity was negligible in rat and monkey mucosal brush borders.	Folic Acid	13-19	gamma-glutamyl hydrolase	Rattus norvegicus	20-29
3839013-6	1985	Intracellular folate conjugase was maximally active at pH 4.5 in the human, pig and monkey, whereas this enzyme was equally active from pH 4.0 to 7.5 in the rat.	Folic Acid	14-20	gamma-glutamyl hydrolase	Rattus norvegicus	21-30
3839013-8	1985	Although folate conjugase was quantitatively more active in the human than in the pig intestine, the brush border and intracellular enzymes exhibited similar properties.	Folic Acid	9-15	gamma-glutamyl hydrolase	Rattus norvegicus	16-25
6546690-6	1984	Folyl polyglutamate synthetase was competitively inhibited by mAPA-HCysA (K1 = 190 +/- 70 microM) when folate was the variable substrate.	Folic Acid	103-109	glutamyl aminopeptidase	Mus musculus	62-66
6548957-0	1984	Intestinal folate conjugase activity and folate absorption in the ethanol-fed pregnant rat.	Folic Acid	11-17	gamma-glutamyl hydrolase	Rattus norvegicus	18-27
240786-0	1975	Folic acid conjugase from plasma.	Folic Acid	0-10	gamma-glutamyl hydrolase	Rattus norvegicus	11-20
4470595-0	1974	Effects of folic acid on glucose-6-phosphate dehydrogenase and renin activities of the rat kidney.	Folic Acid	11-21	glucose-6-phosphate dehydrogenase	Rattus norvegicus	25-58
4470595-0	1974	Effects of folic acid on glucose-6-phosphate dehydrogenase and renin activities of the rat kidney.	Folic Acid	11-21	renin	Rattus norvegicus	63-68
4142233-0	1973	[Proceedings: Renin secretion and juxtaglomerular apparatus in folic-acid-induced kidney failure in the rat].	Folic Acid	63-73	renin	Rattus norvegicus	14-19
4347297-0	1972	Effect of folic acid on plasma renin activity in rats.	Folic Acid	10-20	renin	Rattus norvegicus	31-36
33931588-9	2021	In vivo, in mice with folic acid-induced progressive CKD, targeting of GSK3beta in renal tubules via genetic ablation or by microdose lithium mitigated the profibrogenic plasticity of TEC, concomitant with attenuated interstitial fibrosis and tubular atrophy.	Folic Acid	22-32	glycogen synthase kinase 3 alpha	Mus musculus	71-79
31421459-2	2019	Methylenetetrahydrofolate dehydrogenase 1 like (MTHFD1L), an enzyme in the folate cycle, is involved in formate generation and therefore in one-carbon metabolism.	Folic Acid	19-25	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like	Homo sapiens	48-55
31619709-13	2019	By contrast, high concentrations of folic acid in vitro supported VEGF-C-dependent ANGPT2 overexpression might potentiate micro-lymphatic vessel development to support malignant cell dissemination.	Folic Acid	36-46	angiopoietin 2	Homo sapiens	83-89
30920123-0	2019	DNA Hypomethylation of GR Promoters is Associated with GR Activation and BDNF/AKT/ERK1/2-Induced Hippocampal Neurogenesis in Mice Derived From Folic-Acid-Supplemented Dams.	Folic Acid	143-153	mitogen-activated protein kinase 3	Mus musculus	82-88
32276275-0	2020	A homozygous deletion in the SLC19A1 gene as a cause of folate-dependent recurrent megaloblastic anemia.	Folic Acid	56-62	solute carrier family 19 member 1	Homo sapiens	29-36
32029499-4	2020	Currently, there is a lack of evidence to support if the 2.8 mg folic acid per week dose is sufficient to raise erythrocyte folate concentrations to a level associated with a reduced risk of a NTD-affected pregnancy.	Folic Acid	64-74	fuzzy planar cell polarity protein	Homo sapiens	193-196
30867454-1	2019	In folate-mediated one-carbon metabolism (FOCM), 5-formyltetrahydrofolate (5fTHF), a one-carbon substituted tetrahydrofolate (THF) vitamer, acts as an intracellular storage form of folate and as an inhibitor of the folate-dependent enzymes phosphoribosylaminoimidazolecarboxamide formyltransferase (AICARFT) and serine hydroxymethyltransferase (SHMT).	Folic Acid	3-9	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	299-306
30670450-0	2019	Folic acid modifies the shape of epithelial cells during morphogenesis via a Folr1 and MLCK dependent mechanism.	Folic Acid	0-10	myosin light chain kinase 3	Mus musculus	87-91
30670450-5	2019	Utilizing an epithelial cell culture model of apical constriction, it was observed that treatment with exogenous folic acid, as well as co-expression of the folic acid receptor Folr1, can rescue the function of the Rho-kinase binding deficient mutant of Shroom3 in vitro It was also determined that the rescuing ability of folic acid is RhoA and Rho-kinase independent but myosin light chain kinase (MLCK) and Src-kinase dependent.	Folic Acid	113-123	ras homolog family member A	Mus musculus	337-341
30670450-5	2019	Utilizing an epithelial cell culture model of apical constriction, it was observed that treatment with exogenous folic acid, as well as co-expression of the folic acid receptor Folr1, can rescue the function of the Rho-kinase binding deficient mutant of Shroom3 in vitro It was also determined that the rescuing ability of folic acid is RhoA and Rho-kinase independent but myosin light chain kinase (MLCK) and Src-kinase dependent.	Folic Acid	113-123	myosin light chain kinase 3	Mus musculus	373-398
30670450-5	2019	Utilizing an epithelial cell culture model of apical constriction, it was observed that treatment with exogenous folic acid, as well as co-expression of the folic acid receptor Folr1, can rescue the function of the Rho-kinase binding deficient mutant of Shroom3 in vitro It was also determined that the rescuing ability of folic acid is RhoA and Rho-kinase independent but myosin light chain kinase (MLCK) and Src-kinase dependent.	Folic Acid	113-123	myosin light chain kinase 3	Mus musculus	400-404
32029499-5	2020	We aim to conduct a three-arm randomised controlled trial to determine the effect of weekly folic acid with iron on erythrocyte folate, a biomarker of NTD risk.	Folic Acid	92-102	fuzzy planar cell polarity protein	Homo sapiens	151-154
30670450-5	2019	Utilizing an epithelial cell culture model of apical constriction, it was observed that treatment with exogenous folic acid, as well as co-expression of the folic acid receptor Folr1, can rescue the function of the Rho-kinase binding deficient mutant of Shroom3 in vitro It was also determined that the rescuing ability of folic acid is RhoA and Rho-kinase independent but myosin light chain kinase (MLCK) and Src-kinase dependent.	Folic Acid	157-167	ras homolog family member A	Mus musculus	337-341
30670450-5	2019	Utilizing an epithelial cell culture model of apical constriction, it was observed that treatment with exogenous folic acid, as well as co-expression of the folic acid receptor Folr1, can rescue the function of the Rho-kinase binding deficient mutant of Shroom3 in vitro It was also determined that the rescuing ability of folic acid is RhoA and Rho-kinase independent but myosin light chain kinase (MLCK) and Src-kinase dependent.	Folic Acid	157-167	myosin light chain kinase 3	Mus musculus	373-398
32029499-5	2020	We aim to conduct a three-arm randomised controlled trial to determine the effect of weekly folic acid with iron on erythrocyte folate, a biomarker of NTD risk.	Folic Acid	128-134	fuzzy planar cell polarity protein	Homo sapiens	151-154
30670450-5	2019	Utilizing an epithelial cell culture model of apical constriction, it was observed that treatment with exogenous folic acid, as well as co-expression of the folic acid receptor Folr1, can rescue the function of the Rho-kinase binding deficient mutant of Shroom3 in vitro It was also determined that the rescuing ability of folic acid is RhoA and Rho-kinase independent but myosin light chain kinase (MLCK) and Src-kinase dependent.	Folic Acid	157-167	myosin light chain kinase 3	Mus musculus	400-404
30670450-6	2019	Inhibition of Rho-kinase-dependent apical constriction in chick embryo neural epithelium was also observed to be rescued by exogenous folic acid and that treatment with folic acid is accompanied by elevated activated myosin light chain and MLCK.	Folic Acid	169-179	myosin, heavy chain 15	Gallus gallus	217-223
31647103-3	2020	Among the identified genes, we discovered MET7, which encodes folylpolyglutamate synthetase (FPGS), an enzyme that facilitates several folate-dependent reactions including the synthesis of purines, thymidylate (dTMP) and DNA methylation.	Folic Acid	135-141	tetrahydrofolate synthase	Saccharomyces cerevisiae S288C	42-46
31826386-0	2019	Genetic and epigenetic regulation of BHMT is associated with folate therapy efficacy in hyperhomocysteinaemia.	Folic Acid	61-67	betaine--homocysteine S-methyltransferase	Homo sapiens	37-41
33152447-9	2021	Notably, CB2 potentiated Wnt1-induced beta-arrestin 1/beta-catenin activation and augmented the pathogenesis of kidney fibrosis in mice with unilateral ischemia-reperfusion injury or folic acid-induced nephropathy.. Knockdown of beta-arrestin 1 inhibited the CB2 agonist AM1241-induced beta-catenin activation and kidney fibrosis.	Folic Acid	183-193	wingless-type MMTV integration site family, member 1	Mus musculus	25-29
33126053-0	2021	Targeting feed-forward signaling of TGFbeta/NOX4/DHFR/eNOS uncoupling/TGFbeta axis with anti-TGFbeta and folic acid attenuates formation of aortic aneurysms: Novel mechanisms and therapeutics.	Folic Acid	105-115	NADPH oxidase 4	Mus musculus	44-48
33392094-8	2020	Intraperitoneal injections of miR-18a-OMM-loaded folate-conjugated liposomes significantly reduced the tumor weight and the number of nodules in ovarian cancer-bearing mice when compared with a control-OMM group.	Folic Acid	49-55	microRNA 18	Mus musculus	30-37
33315905-7	2020	We used robust linear regression to investigate interactions between genotype and folate level on the highest EPDS and CARS-M scores, and logistic regression to explore interactions with PANSS psychosis scores above/below cut-off.	Folic Acid	82-88	cysteinyl-tRNA synthetase 1	Homo sapiens	119-123
33459508-1	2020	BACKGROUND: To investigate whether folic acid (FA) can rescue anorectal malformations (ARMs) induced by all-trans retinoic acid (ATRA) in rats.	Folic Acid	35-45	glycogen synthase kinase 3 beta	Rattus norvegicus	47-49
33262182-2	2020	An article in this issue of Cancer Discovery identifies a nongenetic mechanism of resistance related to deficiency of folate that leads, via increased S-adenosylhomocysteine and reduced repressive histone methylation, to reactivation of a transcriptional program which promotes AML cell survival under the pressure of BET inhibition.See related article by Su et al., p. 1894.	Folic Acid	118-124	delta/notch like EGF repeat containing	Homo sapiens	318-321
33164984-3	2020	The folate pathway genes SLC19A1, ABCC1, ABCC4, FPGS, and MTHFD1 significantly influenced intracellular MTXPG levels (P = 2.9 x 10-3 to 3.7 x 10-8).	Folic Acid	4-10	solute carrier family 19 member 1	Homo sapiens	25-32
32521439-1	2020	The aim of this study was to determine how folate and iron deficiency, and the subsequent supplementation of rats" diet with these nutrients, affects Slc19a1and Tfr2 gene expression and the metabolism of folate and iron.	Folic Acid	43-49	solute carrier family 19 member 1	Rattus norvegicus	150-157
33266291-4	2020	Serine hydroxymethyltransferase (SHMT) is indispensable for the one-carbon metabolism of serine/glycine interconversion and is linked to folate metabolism.	Folic Acid	137-143	AT695_RS06945	Staphylococcus aureus	0-31
33266291-4	2020	Serine hydroxymethyltransferase (SHMT) is indispensable for the one-carbon metabolism of serine/glycine interconversion and is linked to folate metabolism.	Folic Acid	137-143	AT695_RS06945	Staphylococcus aureus	33-37
32915913-10	2020	Genes, including Ttc38, Sema3A, Insl3, Dll1, Msh4 and Snai1, were the novel factors that may be associated with the development of the kidneys and related to folic acid treatment.	Folic Acid	158-168	tetratricopeptide repeat domain 38	Mus musculus	17-22
32915913-10	2020	Genes, including Ttc38, Sema3A, Insl3, Dll1, Msh4 and Snai1, were the novel factors that may be associated with the development of the kidneys and related to folic acid treatment.	Folic Acid	158-168	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	Mus musculus	24-30
32915913-10	2020	Genes, including Ttc38, Sema3A, Insl3, Dll1, Msh4 and Snai1, were the novel factors that may be associated with the development of the kidneys and related to folic acid treatment.	Folic Acid	158-168	mutS homolog 4	Mus musculus	45-49
32061804-2	2020	Folic acid supplementation has been shown to prevent the occurrence of NTDs by as much as 70% in some human populations, and folate deficiency in a pregnant woman is associated with increased risk for having an NTD affected infant.	Folic Acid	0-10	fuzzy planar cell polarity protein	Homo sapiens	71-74
32061804-4	2020	Herein, we review the genes involved in folate transport and one carbon metabolism thus far identified as contributing variants that influence human NTD risk, and place these findings in the context of our evolving understanding of the complex genetic architecture underlying these defects.	Folic Acid	40-46	fuzzy planar cell polarity protein	Homo sapiens	149-152
32173264-8	2020	Stress response of neurons indicated as c-Fos expression was also reduced in the DG of low folate diet-fed mice.	Folic Acid	91-97	steroid sulfatase	Mus musculus	37-41
32019627-6	2020	Folate catabolite apABG was positively correlated with IL-6 (r= 0.27, plinear&lt;0.0001) and pABG was positively correlated with IL-8 (r= 0.21, plinear&lt;0.0001), indicating higher folate utilization during inflammation.Our data support the hypothesis of inverse associations between PLP and inflammatory biomarkers among colorectal cancer patients.	Folic Acid	0-6	pyridoxal phosphatase	Homo sapiens	285-288
32266834-5	2020	Results: The study demonstrates that the genetic variants in folate cycle and methionine cycle genes such as MTHFR, MTRR, MTR, BHMT and DNMT1 are associated with the risk of aneurysm.	Folic Acid	61-67	betaine--homocysteine S-methyltransferase	Homo sapiens	127-131
31605575-6	2020	Moreover, FA/MOF/DOX nanoparticles could enhance the delivery efficacy of DOX into MG63 (human osteosarcoma) cells as compared to FA free nanoparticles (MOF/DOX), in which a folate receptor (FR) might be involved.	Folic Acid	174-180	lysine acetyltransferase 8	Homo sapiens	10-20
31605575-6	2020	Moreover, FA/MOF/DOX nanoparticles could enhance the delivery efficacy of DOX into MG63 (human osteosarcoma) cells as compared to FA free nanoparticles (MOF/DOX), in which a folate receptor (FR) might be involved.	Folic Acid	174-180	lysine acetyltransferase 8	Homo sapiens	13-16
32368304-0	2020	High expression of folate cycle enzyme MTHFD1L correlates with poor prognosis and increased proliferation and migration in colorectal cancer.	Folic Acid	19-25	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like	Homo sapiens	39-46
31994802-10	2020	The transcriptomic analysis revealed that folic acid treatment regulated many key metabolic-related genes (DGAT2, ALOX5, LAP3, GPAT3, GGH, ALDOA, TKT) and pathways (glycolysis, folate biosynthesis, glutathione metabolism, etc.)	Folic Acid	42-52	diacylglycerol O-acyltransferase 2	Bos taurus	107-112
31994802-10	2020	The transcriptomic analysis revealed that folic acid treatment regulated many key metabolic-related genes (DGAT2, ALOX5, LAP3, GPAT3, GGH, ALDOA, TKT) and pathways (glycolysis, folate biosynthesis, glutathione metabolism, etc.)	Folic Acid	42-52	leucine aminopeptidase 3	Bos taurus	121-125
31721048-0	2020	Folic Acid Protects Rat Cerebellum Against Oxidative Damage Caused by Homocysteine: the Expression of Bcl-2, Bax, and Caspase-3 Apoptotic Genes.	Folic Acid	0-10	caspase 3	Rattus norvegicus	118-127
31721048-11	2020	Folic acid significantly reduced MDA level, protein carbonyl content, Bax, the caspase-3 mRNA, and protein expression levels in the cerebellum of Hcy-treated group.	Folic Acid	0-10	caspase 3	Rattus norvegicus	79-88
31656209-0	2020	Simultaneous supplementation with iron and folic acid can affect Slc11a2 and Slc46a1 transcription and metabolite concentrations in rats.	Folic Acid	43-53	solute carrier family 46 member 1	Rattus norvegicus	77-84
31672625-6	2019	Furthermore, tumor growth was significantly inhibited by folate-targeted NPs loaded with the low-dose DOX/miR-200c combination, but not by treatments with free DOX, miR-NPs or DOX-NPs.	Folic Acid	57-63	microRNA 200c	Homo sapiens	106-114
30744448-1	2019	BACKGROUND: To prepare sorafenib-loaded folate-decorated bovine serum nanoparticles (FA-SRF-BSANPs) and investigate their effect on the tumor targeting.	Folic Acid	40-46	serum response factor	Mus musculus	88-91
30744448-3	2019	RESULTS: SRF-loaded BSA nanoparticles (SRF-BSANPs) was first prepared and modified with folic acid by chemical coupling to obtain FA-SRF-BSANPs.	Folic Acid	88-98	serum response factor	Mus musculus	9-12
30744448-3	2019	RESULTS: SRF-loaded BSA nanoparticles (SRF-BSANPs) was first prepared and modified with folic acid by chemical coupling to obtain FA-SRF-BSANPs.	Folic Acid	88-98	serum response factor	Mus musculus	39-42
30744448-3	2019	RESULTS: SRF-loaded BSA nanoparticles (SRF-BSANPs) was first prepared and modified with folic acid by chemical coupling to obtain FA-SRF-BSANPs.	Folic Acid	88-98	serum response factor	Mus musculus	39-42
31366257-8	2019	Overall, these results indicate that Bmi1 as a regulating gene for cancer stem cell is an effective target for cancer treatment using siRNA and co-delivery of UA and Bmi1 siRNA using folate-targeted liposomes is a promising strategy for improved anti-tumor effect.	Folic Acid	183-189	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	37-41
31366257-8	2019	Overall, these results indicate that Bmi1 as a regulating gene for cancer stem cell is an effective target for cancer treatment using siRNA and co-delivery of UA and Bmi1 siRNA using folate-targeted liposomes is a promising strategy for improved anti-tumor effect.	Folic Acid	183-189	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	166-170
31452255-3	2019	The goal of this study was to determine whether folate is involved in GnAQ methylation and its effect on GnRH secretion.	Folic Acid	48-54	guanine nucleotide-binding protein G(q) subunit alpha	Ovis aries	70-74
31452255-7	2019	GnAQ expression was related to folate concentration and showed a trend of increasing first and then decreasing.	Folic Acid	31-37	guanine nucleotide-binding protein G(q) subunit alpha	Ovis aries	0-4
31504109-6	2019	The folate insufficiency prevalence (RBC folate &lt;748 nmol/L; NTD risk) in women decreased from 2007-2010 (23.2%) to 2011-2016 (18.6%) overall and in some subgroups (e.g., women aged 20-39 y, Hispanic and non-Hispanic black women, and supplement nonusers).	Folic Acid	4-10	fuzzy planar cell polarity protein	Homo sapiens	64-67
30855221-5	2019	Furthermore, association between CA 15-3 level and megaloblastic anemia due to folic acid deficiency was evaluated.	Folic Acid	79-89	mucin 1, cell surface associated	Homo sapiens	33-40
30855221-7	2019	CA 15-3 levels were significantly higher among patients with vitamin B12- and folic acid-associated megaloblastic anemia compared to the normal group (p = 0.001 and p = 0.005, respectively).	Folic Acid	78-88	mucin 1, cell surface associated	Homo sapiens	0-7
31401334-6	2019	MTHFD1L is a mitochondrial enzyme involved in the folate cycle by catalyzing the reaction of formyl-tetrahydrofolate to formate and tetrahydrofolate (THF).	Folic Acid	50-56	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like	Homo sapiens	0-7
31377317-8	2019	Bioinformatics analyses indicated that CHAF1A correlated with folate metabolism and the expression of thymidylate synthetase (TS).	Folic Acid	62-68	chromatin assembly factor 1 subunit A	Homo sapiens	39-45
31619709-0	2019	The contribution of dietary and plasma folate and cobalamin to levels of angiopoietin-1, angiopoietin-2 and Tie-2 receptors depend on vascular endothelial growth factor status of primary breast cancer patients.	Folic Acid	39-45	angiopoietin 1	Homo sapiens	73-87
31619709-0	2019	The contribution of dietary and plasma folate and cobalamin to levels of angiopoietin-1, angiopoietin-2 and Tie-2 receptors depend on vascular endothelial growth factor status of primary breast cancer patients.	Folic Acid	39-45	angiopoietin 2	Homo sapiens	89-103
31619709-0	2019	The contribution of dietary and plasma folate and cobalamin to levels of angiopoietin-1, angiopoietin-2 and Tie-2 receptors depend on vascular endothelial growth factor status of primary breast cancer patients.	Folic Acid	39-45	TEK receptor tyrosine kinase	Homo sapiens	108-113
31619709-1	2019	The aim of this study was to determine the association of dietary folate and cobalamin with plasma levels of Angiopoietins (ANG), vascular endothelial growth factor-C (VEGF-C) and tyrosine kinase receptor-2 (Tie-2) of primary breast cancer patients.	Folic Acid	66-72	TEK receptor tyrosine kinase	Homo sapiens	180-206
31619709-7	2019	Dietary intake of folate and cobalamin showed a significant inverse correlation with plasma ANG-1 and ANG-2 (P < 0.05), particularly in subjects with estrogen-receptor positive tumors or low plasma VEGF-C.	Folic Acid	18-24	angiopoietin 1	Homo sapiens	92-97
31619709-7	2019	Dietary intake of folate and cobalamin showed a significant inverse correlation with plasma ANG-1 and ANG-2 (P < 0.05), particularly in subjects with estrogen-receptor positive tumors or low plasma VEGF-C.	Folic Acid	18-24	angiopoietin 2	Homo sapiens	102-107
31619709-8	2019	Plasma folate was positively associated with the ratio of ANG-1/ANG-2 (P < 0.05).	Folic Acid	7-13	angiopoietin 1	Homo sapiens	58-63
31619709-8	2019	Plasma folate was positively associated with the ratio of ANG-1/ANG-2 (P < 0.05).	Folic Acid	7-13	angiopoietin 2	Homo sapiens	64-69
31619709-11	2019	Folic acid treatment resulted in dose-dependent down-regulations on ANGPT1 and ANGPT1/ANGPT2 ratio but VEGF and ANGPT2/VEGF were upregulated at folic acid >20 muM.	Folic Acid	0-10	angiopoietin 1	Homo sapiens	68-74
31619709-11	2019	Folic acid treatment resulted in dose-dependent down-regulations on ANGPT1 and ANGPT1/ANGPT2 ratio but VEGF and ANGPT2/VEGF were upregulated at folic acid >20 muM.	Folic Acid	0-10	angiopoietin 1	Homo sapiens	79-85
31619709-11	2019	Folic acid treatment resulted in dose-dependent down-regulations on ANGPT1 and ANGPT1/ANGPT2 ratio but VEGF and ANGPT2/VEGF were upregulated at folic acid >20 muM.	Folic Acid	0-10	angiopoietin 2	Homo sapiens	86-92
30970178-8	2019	According to the proposed RBC (906 nmol L-1 ) concentrations for optimal NTD prevention, 42.4% participants had RBC folate insufficiency.	Folic Acid	116-122	fuzzy planar cell polarity protein	Homo sapiens	73-76
30970178-12	2019	Actions that aim to improve folic acid supplementation compliance are needed to reach the full potential of the nationwide folic acid supplementation programme in terms of NTD prevention.	Folic Acid	123-133	fuzzy planar cell polarity protein	Homo sapiens	172-175
31295411-6	2019	The folic acid treatment of diabetic rats did not change aminotransferase activity; it alleviated the increase in alkaline phosphatase and the decrease in albumin and fibrinogen concentration, and reduced MMP-2 activity; however, it increased urea and creatinine concentration.	Folic Acid	4-14	matrix metallopeptidase 2	Rattus norvegicus	205-210
31511694-7	2019	Here we used a genome-wide CRISPR-interference screen to identify the reduced folate carrier SLC19A1, a folate-organic phosphate antiporter, as the major transporter of CDNs.	Folic Acid	78-84	solute carrier family 19 member 1	Homo sapiens	93-100
31134434-3	2019	The objective of this study was to report the synthesis and characteristics of a dual-modality imaging agent, Tc-99m Folate-Gly-His-Glu-Gly-Glu-Cys-Gly-Lys(-5-carboxy-X-rhodamine)-NH2 (Folate-ECG-ROX), and verify its feasibility as both molecular imaging agent and intra-operative guidance.	Folic Acid	117-123	max binding protein	Mus musculus	196-199
31134434-5	2019	Radiolabeling of Folate-ECG-ROX with Tc-99m was done using ligand exchange via tartrate.	Folic Acid	17-23	max binding protein	Mus musculus	28-31
31134434-10	2019	RESULTS: After radiolabeling procedures with Tc-99m, Tc-99m Folate-ECG-ROX complexes were prepared in high yield (&gt; 97%).	Folic Acid	60-66	max binding protein	Mus musculus	71-74
31134434-11	2019	The binding affinity value (Kd) of Tc-99m Folate-ECG-ROX for KB cells was estimated to be 6.9 +- 0.9 nM.	Folic Acid	42-48	max binding protein	Mus musculus	53-56
31134434-12	2019	In gamma camera imaging, tumor to normal muscle uptake ratio of Tc-99m Folate-ECG-ROX increased with time (3.4 +- 0.4, 4.4 +- 0.7, and 6.6 +- 0.8 at 1, 2, and 3 h, respectively).	Folic Acid	71-77	max binding protein	Mus musculus	82-85
31134434-14	2019	Confocal microscopy with immunohistochemistry staining detected strong Tc-99m Folate-ECG-ROX fluorescence within KB tumor tissue which is correlating with the fluorescent activity of anti-FR antibody.	Folic Acid	78-84	max binding protein	Mus musculus	89-92
31134434-16	2019	CONCLUSIONS: In vivo and in vitro studies revealed substantial and specific uptake of Tc-99m Folate-ECG-ROX in FR-positive tumors.	Folic Acid	93-99	max binding protein	Mus musculus	104-107
31134434-17	2019	Thus, Tc-99m Folate-ECG-ROX could provide both pre-operative molecular imaging and fluorescence image-guidance for tumor.	Folic Acid	13-19	max binding protein	Mus musculus	24-27
31167838-5	2019	The positive controls, methotrexate and pemetrexed, demonstrated clinically relevant inhibition of PCFT, RFC, and FRalpha in folate absorption, distribution, and renal sparing.	Folic Acid	125-131	solute carrier family 19 member 1	Homo sapiens	105-108
30955184-8	2019	Folate was significantly positively associated with invasive and estrogen receptor-positive/progesterone receptor-positive breast cancer, and this association was suggestively stronger for bloods collected post-fortification.	Folic Acid	0-6	progesterone receptor	Homo sapiens	92-113
30804256-0	2019	A high methionine, low folate and vitamin B6/B12 containing diet can be associated with memory loss by epigenetic silencing of netrin-1.	Folic Acid	23-29	netrin 1	Mus musculus	127-135
30804256-6	2019	Mice fed with a high methionine, low folate and vitamins containing diet showed a decrease in netrin-1 protein expression and an increase in netrin-1 gene promotor methylation, as determined by methylation-sensitive restriction enzyme-polymerase chain reaction analysis.	Folic Acid	37-43	netrin 1	Mus musculus	94-102
30804256-6	2019	Mice fed with a high methionine, low folate and vitamins containing diet showed a decrease in netrin-1 protein expression and an increase in netrin-1 gene promotor methylation, as determined by methylation-sensitive restriction enzyme-polymerase chain reaction analysis.	Folic Acid	37-43	netrin 1	Mus musculus	141-149
31171577-8	2019	Strikingly, the anterior cleft palate in Cbfb mutants is further rescued by pharmaceutical application of folic acid, which activates suppressed Stat3 phosphorylation and Tgfb3 expression in vitro With these findings, we provide the first evidence that Cbfb is a prerequisite for anterior palatogenesis and acts as an obligatory cofactor in the Runx1/Cbfb-Stat3-Tgfb3 signaling axis.	Folic Acid	106-116	core binding factor beta	Mus musculus	41-45
31171577-8	2019	Strikingly, the anterior cleft palate in Cbfb mutants is further rescued by pharmaceutical application of folic acid, which activates suppressed Stat3 phosphorylation and Tgfb3 expression in vitro With these findings, we provide the first evidence that Cbfb is a prerequisite for anterior palatogenesis and acts as an obligatory cofactor in the Runx1/Cbfb-Stat3-Tgfb3 signaling axis.	Folic Acid	106-116	core binding factor beta	Mus musculus	253-257
31171577-8	2019	Strikingly, the anterior cleft palate in Cbfb mutants is further rescued by pharmaceutical application of folic acid, which activates suppressed Stat3 phosphorylation and Tgfb3 expression in vitro With these findings, we provide the first evidence that Cbfb is a prerequisite for anterior palatogenesis and acts as an obligatory cofactor in the Runx1/Cbfb-Stat3-Tgfb3 signaling axis.	Folic Acid	106-116	core binding factor beta	Mus musculus	253-257
30996094-6	2019	Here, phenotypic screening of a human/hamster radiation hybrid panel identified SLC19A1, a feline reduced folate carrier (RFC) and potential receptor for TG35-2-phenotypic virus.	Folic Acid	106-112	solute carrier family 19 member 1	Homo sapiens	122-125
31558761-0	2019	Association between BHMT and CBS gene promoter methylation with the efficacy of folic acid therapy in patients with hyperhomocysteinemia.	Folic Acid	80-90	betaine--homocysteine S-methyltransferase	Homo sapiens	20-24
31558761-3	2019	The present study is performed to explore the association between the methylation levels in the promoter regions of the BHMT and CBS genes and the efficacy of folic acid therapy in patient with hyperhomocysteinemia (HHcy).	Folic Acid	159-169	betaine--homocysteine S-methyltransferase	Homo sapiens	120-124
31558761-10	2019	These studies suggest that lower levels of BHMT and CBS methylation are all predictors of failure in folic acid therapy for HHcy.	Folic Acid	101-111	betaine--homocysteine S-methyltransferase	Homo sapiens	43-47
31537252-2	2019	Knocking down the mouse gene Mtrr impedes the progression of folate and methionine metabolism and results in hyperhomocysteinaemia, dysregulation of DNA methylation and developmental phenotypes (e.g. neural tube, heart and placenta defects).	Folic Acid	61-67	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Mus musculus	29-33
31349118-10	2019	In vivo in folic acid-injured mice, targeting GSK3beta in renal tubules via conditional knockout or by weekly microdose lithium treatment reinstated Nrf2 antioxidant response in the kidney and hindered AKI to CKD transition.	Folic Acid	11-21	glycogen synthase kinase 3 alpha	Mus musculus	46-54
31223065-8	2019	A high tumoral expression of the genes SLC46A1/PCFT, SLC19A1/RFC-1, ABCC3/MRP3, GGH, and MTHFD1L, which are involved in folate transport, polyglutamation, or metabolism, was associated with longer disease-free survival of the patients.	Folic Acid	120-126	solute carrier family 19 member 1	Homo sapiens	53-60
31223065-8	2019	A high tumoral expression of the genes SLC46A1/PCFT, SLC19A1/RFC-1, ABCC3/MRP3, GGH, and MTHFD1L, which are involved in folate transport, polyglutamation, or metabolism, was associated with longer disease-free survival of the patients.	Folic Acid	120-126	ATP binding cassette subfamily C member 3	Homo sapiens	68-73
31223065-8	2019	A high tumoral expression of the genes SLC46A1/PCFT, SLC19A1/RFC-1, ABCC3/MRP3, GGH, and MTHFD1L, which are involved in folate transport, polyglutamation, or metabolism, was associated with longer disease-free survival of the patients.	Folic Acid	120-126	ATP binding cassette subfamily C member 3	Homo sapiens	74-78
31223065-8	2019	A high tumoral expression of the genes SLC46A1/PCFT, SLC19A1/RFC-1, ABCC3/MRP3, GGH, and MTHFD1L, which are involved in folate transport, polyglutamation, or metabolism, was associated with longer disease-free survival of the patients.	Folic Acid	120-126	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like	Homo sapiens	89-96
30076082-10	2019	Furthermore, the strength of right SMA-seeded connectivity with insula was positively correlated with folic acid level in HM patients (r = 0.60, p = 0.03), showing an accuracy of 0.87 to distinguish HM from non-HM.	Folic Acid	102-112	survival of motor neuron 1, telomeric	Homo sapiens	35-38
30884643-5	2019	In the presence of folic acid, encapsulation was achieved as evidenced by the yellow coloration, intact surface morphology (SEM), the presence of nitrogen (23.08% N; EDX), and thermal gravimetric degradation for folic acid (28% FA; TGA).	Folic Acid	19-29	T-box transcription factor 1	Homo sapiens	232-235
30940212-12	2019	Evidence from DMR and FL analyses indicated that dietary folate and alcohol intake may be associated with genomic regions with tumor suppressor activity such as the GSDMD and HOXA5 genes.	Folic Acid	57-63	gasdermin D	Homo sapiens	165-170
30447272-7	2019	Furthermore, maternal folic acid deficiency increased the ratio of cleaved caspase-3/caspase-3, followed by an increase in caspase-3 activity.	Folic Acid	22-32	caspase 3	Rattus norvegicus	75-84
30324648-0	2019	Reduced folate carrier-mediated methotrexate transport in human distal lung epithelial NCl-H441 cells.	Folic Acid	8-14	nucleolin	Homo sapiens	87-90
30324648-1	2019	OBJECTIVES: We had previously found that reduced folate carrier (RFC; SLC19A1) is mainly involved in an influx of transport of methotrexate (MTX), a folate analogue, using alveolar epithelial A549 cells.	Folic Acid	49-55	solute carrier family 19 member 1	Homo sapiens	65-68
30324648-1	2019	OBJECTIVES: We had previously found that reduced folate carrier (RFC; SLC19A1) is mainly involved in an influx of transport of methotrexate (MTX), a folate analogue, using alveolar epithelial A549 cells.	Folic Acid	49-55	solute carrier family 19 member 1	Homo sapiens	70-77
30324648-1	2019	OBJECTIVES: We had previously found that reduced folate carrier (RFC; SLC19A1) is mainly involved in an influx of transport of methotrexate (MTX), a folate analogue, using alveolar epithelial A549 cells.	Folic Acid	149-155	solute carrier family 19 member 1	Homo sapiens	65-68
30324648-1	2019	OBJECTIVES: We had previously found that reduced folate carrier (RFC; SLC19A1) is mainly involved in an influx of transport of methotrexate (MTX), a folate analogue, using alveolar epithelial A549 cells.	Folic Acid	149-155	solute carrier family 19 member 1	Homo sapiens	70-77
30324648-5	2019	In addition, folic acid and thiamine monophosphate, RFC inhibitors, inhibited the uptake of MTX from the basolateral side of the H441 cells.	Folic Acid	13-23	solute carrier family 19 member 1	Homo sapiens	52-55
29688120-3	2019	In this study, we prepared folate and TAT (arginine-rich cell-penetrating peptide) modified N-PEG-N"-octyl-chitosan to form the folate/TAT-PEG-OC micelles.	Folic Acid	27-33	tyrosine aminotransferase	Homo sapiens	135-138
31494266-7	2019	Moreover, significant genetic diversity in MTHFR, TCN2, FADS1, and FADS2, which associate with circulating folate, vitamin B12, or lipid metabolism, was observed between northerners and southerners.	Folic Acid	107-113	transcobalamin 2	Homo sapiens	50-54
31191875-8	2019	For example, the folate conjugate FA-7-Val-Cit-pABA-16R-aminoratjadone had an IC50 of 34.3 nM, and the LHRH conjugate d-Orn-Gose-Val-Cit-pABA-16R-aminoratjadone had an IC50 of 12.8 nM.	Folic Acid	17-23	gonadotropin releasing hormone 1	Homo sapiens	103-107
31975775-4	2019	In a recent study, we demonstrated that folic acid (FA) treatment to cSCI rats reduced NP and improved functional recovery by repressing MMP-2 expression.	Folic Acid	40-50	matrix metallopeptidase 2	Rattus norvegicus	137-142
30867454-1	2019	In folate-mediated one-carbon metabolism (FOCM), 5-formyltetrahydrofolate (5fTHF), a one-carbon substituted tetrahydrofolate (THF) vitamer, acts as an intracellular storage form of folate and as an inhibitor of the folate-dependent enzymes phosphoribosylaminoimidazolecarboxamide formyltransferase (AICARFT) and serine hydroxymethyltransferase (SHMT).	Folic Acid	67-73	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	299-306
30867454-1	2019	In folate-mediated one-carbon metabolism (FOCM), 5-formyltetrahydrofolate (5fTHF), a one-carbon substituted tetrahydrofolate (THF) vitamer, acts as an intracellular storage form of folate and as an inhibitor of the folate-dependent enzymes phosphoribosylaminoimidazolecarboxamide formyltransferase (AICARFT) and serine hydroxymethyltransferase (SHMT).	Folic Acid	67-73	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	299-306
30920008-1	2019	BACKGROUND: We sought to assess the recent trend in NTD prevalence at birth in the post-folic acid food fortification era and to identify the maternal risk factors associated with that trend.	Folic Acid	88-98	fuzzy planar cell polarity protein	Homo sapiens	52-55
30447272-7	2019	Furthermore, maternal folic acid deficiency increased the ratio of cleaved caspase-3/caspase-3, followed by an increase in caspase-3 activity.	Folic Acid	22-32	caspase 3	Rattus norvegicus	85-94
30447272-7	2019	Furthermore, maternal folic acid deficiency increased the ratio of cleaved caspase-3/caspase-3, followed by an increase in caspase-3 activity.	Folic Acid	22-32	caspase 3	Rattus norvegicus	85-94
30372582-7	2018	Individuals with CC genotype had a significantly greater PWV response to folic acid supplementation than did carriers of the T allele (beta = -2.79, P &lt; 0.001 for CC homozygotes compared with beta = -0.56, P = 0.464 for TT homozygotes).	Folic Acid	73-83	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	135-144
30397232-5	2018	Given downregulation of Tgfb1 expression by folic acid, antioxidant Tempol reversed DNA demethylation, with increased and decreased recruitment of DNMT1 and USF1 to the promoter, resulting in decreased Tgfb1 expression in db/db mice.	Folic Acid	44-54	transforming growth factor, beta 1	Mus musculus	24-29
30236873-12	2018	Changes in the LXRalpha promoter methylation might be related to the availability of the methyl donor folate.	Folic Acid	102-108	nuclear receptor subfamily 1 group H member 3	Homo sapiens	15-23
30347751-3	2018	Paclitaxel (PTX) was loaded in mesoporous silica nanoparticles with a hydrophobic internal channel, and folic acid (FA) functionalized beta-Cyclodextrin (beta-CD) was capped on the surface of the nanoparticles (DESN), which acted as a cancer-targeting moiety and solubilizer.	Folic Acid	104-114	beta-carotene oxygenase 1	Mus musculus	154-161
30175824-1	2018	Novel matrix metalloproteinase 2 (MMP2)-sensitive nanoparticles (NPs) are developed with copolymers of TPGS3350-pp-PLGA and TPGS-folate to overcome some drawbacks of traditional anticancer formulations in drug delivery, such as short circulation time in blood, small drug accumulation at the tumor site, low intracellular uptake, etc.	Folic Acid	129-135	matrix metallopeptidase 2	Homo sapiens	6-32
30175824-1	2018	Novel matrix metalloproteinase 2 (MMP2)-sensitive nanoparticles (NPs) are developed with copolymers of TPGS3350-pp-PLGA and TPGS-folate to overcome some drawbacks of traditional anticancer formulations in drug delivery, such as short circulation time in blood, small drug accumulation at the tumor site, low intracellular uptake, etc.	Folic Acid	129-135	matrix metallopeptidase 2	Homo sapiens	34-38
30402861-10	2018	However, the effects of Hcy on MDA level and expressions of SOD2, eNOS, and ICAM-1 were attenuated by folic acid (Fc) and vitamin B12 (B12) treatment.	Folic Acid	102-112	superoxide dismutase 2	Homo sapiens	60-64
29984403-0	2018	CCL20 blockade increases the severity of nephrotoxic folic acid-induced acute kidney injury.	Folic Acid	53-63	C-C motif chemokine ligand 20	Homo sapiens	0-5
29984403-3	2018	We identified CCL20 as upregulated in a systems biology strategy combining transcriptomics of kidney tissue from experimental toxic folic acid-induced AKI and from stressed cultured tubular cells and have explored the expression and function of CCL20 in experimental and clinical AKI.	Folic Acid	132-142	C-C motif chemokine ligand 20	Homo sapiens	14-19
29984403-4	2018	CCL20 upregulation was confirmed in three models of kidney injury induced by a folic acid overdose, cisplatin or unilateral ureteral obstruction.	Folic Acid	79-89	C-C motif chemokine ligand 20	Homo sapiens	0-5
29380373-10	2018	Folic acid induced nephropathy was associated with the overexpression of inflammatory markers MCP-1, F4/80, type IV collagen, fibronectin and TGF-beta1 compared to control groups, which were partially attenuated by metformin treatment.	Folic Acid	0-10	transforming growth factor, beta 1	Mus musculus	142-151
29380373-12	2018	These results suggest that metoformin attenuates folic acid-induced renal interstitial fibrogenesis through TGF-beta1 signaling pathways.	Folic Acid	49-59	transforming growth factor, beta 1	Mus musculus	108-117
29986308-2	2018	Fetal folate availability is dependent on maternal folate levels and placental folate transport capacity, mediated by two key transporters, Folate Receptor-alpha and Reduced Folate Carrier (RFC).	Folic Acid	6-12	solute carrier family 19 member 1	Homo sapiens	166-188
29986308-2	2018	Fetal folate availability is dependent on maternal folate levels and placental folate transport capacity, mediated by two key transporters, Folate Receptor-alpha and Reduced Folate Carrier (RFC).	Folic Acid	6-12	solute carrier family 19 member 1	Homo sapiens	190-193
29728895-9	2018	Analysis of serum folate and active-B12 levels revealed significant association with LRP2 gene variants in the causation of NTDs.	Folic Acid	18-24	LDL receptor related protein 2	Homo sapiens	85-89
29996520-9	2018	These results associate the potential inflammatory pathway with air pollution and the folate pathway with MTHFR polymorphism.	Folic Acid	86-92	methylenetetrahydrofolate reductase	Meleagris gallopavo	106-111
29636289-0	2018	Folic acid protects against experimental prenatal nicotine-induced cardiac injury by decreasing inflammatory changes, serum TNF and COX-2 expression.	Folic Acid	0-10	tumor necrosis factor-like	Rattus norvegicus	124-127
29636289-12	2018	In conclusion, folic acid has a protective role against nicotine induced cardiac injury by reduction of COX-2 expression, decreasing TNF production and lipid peroxidation mediated cell injury.	Folic Acid	15-25	tumor necrosis factor-like	Rattus norvegicus	133-136
29410110-3	2018	This differential expression of FR-beta provides a mechanism to selectively deliver imaging and therapeutic agents utilizing folate as a targeting molecule.	Folic Acid	125-131	folate receptor 2 (fetal)	Mus musculus	32-39
29231735-2	2018	This study observed that foliar salicylic acid treatment enhanced the accumulation of folates in Arabidopsis, which correlated with the increase in a folate binding protein (FBP) and the expression of mRNA of a putative folate binding protein At5G27830.	Folic Acid	86-93	Inositol monophosphatase family protein	Arabidopsis thaliana	150-172
29231735-2	2018	This study observed that foliar salicylic acid treatment enhanced the accumulation of folates in Arabidopsis, which correlated with the increase in a folate binding protein (FBP) and the expression of mRNA of a putative folate binding protein At5G27830.	Folic Acid	86-93	Inositol monophosphatase family protein	Arabidopsis thaliana	174-177
29231735-2	2018	This study observed that foliar salicylic acid treatment enhanced the accumulation of folates in Arabidopsis, which correlated with the increase in a folate binding protein (FBP) and the expression of mRNA of a putative folate binding protein At5G27830.	Folic Acid	86-93	Inositol monophosphatase family protein	Arabidopsis thaliana	220-242
29231735-6	2018	This novel study of a plant FBP will be useful for folate metabolic engineering of a wide range of crops.	Folic Acid	51-57	Inositol monophosphatase family protein	Arabidopsis thaliana	28-31
30362096-2	2018	Alcohol consumption affects folate-related genes and enzymes including two major folate-metabolizing enzymes, ALDH1L1 and ALDH1L2.	Folic Acid	28-34	aldehyde dehydrogenase 1 family member L2	Homo sapiens	122-129
30362096-2	2018	Alcohol consumption affects folate-related genes and enzymes including two major folate-metabolizing enzymes, ALDH1L1 and ALDH1L2.	Folic Acid	81-87	aldehyde dehydrogenase 1 family member L2	Homo sapiens	122-129
29109127-4	2018	The regulatory locus also expresses two functional RNAs, LINC00925-RNA and MIR9-3, which are coexpressed with POLG The MIR9-3 targets include NR2E1, a transcription factor maintaining neural stem cells in undifferentiated state, and MTHFD2, the regulatory enzyme of mitochondrial folate cycle, linking POLG expression to stem cell differentiation and folate metabolism.	Folic Acid	280-286	MIR9-3 host gene	Homo sapiens	57-66
29171783-8	2017	Western blots showed that HHcy induced a decreased expression of HES1 and HES5, or P62, in which the expression of HES1 and P62 was elevated by treating with folate and vitamin B12 supplement.	Folic Acid	158-164	hes family bHLH transcription factor 1	Mus musculus	65-69
29171783-8	2017	Western blots showed that HHcy induced a decreased expression of HES1 and HES5, or P62, in which the expression of HES1 and P62 was elevated by treating with folate and vitamin B12 supplement.	Folic Acid	158-164	hes family bHLH transcription factor 1	Mus musculus	115-119
28980068-5	2017	A unique methylation pattern co-segregated with affected status: NTD cases had more hypermethylated than hypomethylated CpG islands; genes with different methylations clustered in pathways associated with epithelial-to-mesenchymal transition (ZEB2, SMAD6, and CDH23), folic acid/homocysteine metabolism (MTHFD1L), transcription/nuclear factors (HDAC4, HOXB7, SOX18), cell migration/motility/adhesion, insulin and cell growth, and neuron/axon development.	Folic Acid	268-278	fuzzy planar cell polarity protein	Homo sapiens	65-68
28490073-7	2017	Sodium Dodecyl Sulphate-Polyacrylamide Gel Electrophoresis (SDS-PAGE) analysis revealed the localization of phosvitin in the plasma fraction, which correlated with higher folate concentrations.	Folic Acid	171-177	casein kinase 2 beta	Homo sapiens	108-117
28490073-9	2017	These findings provide evidence of a putative interaction between phosvitin and folate, and offer an improved model for the structure of granule.	Folic Acid	80-86	casein kinase 2 beta	Homo sapiens	66-75
27714636-8	2017	Finally, the detections of folate concentration in human brain tissue and NSCs and MEF cells indicates that folate deficiency contributes to the observed decreases in Mark2 and Dvl1 expression.	Folic Acid	27-33	microtubule affinity regulating kinase 2	Homo sapiens	167-172
27714636-8	2017	Finally, the detections of folate concentration in human brain tissue and NSCs and MEF cells indicates that folate deficiency contributes to the observed decreases in Mark2 and Dvl1 expression.	Folic Acid	108-114	microtubule affinity regulating kinase 2	Homo sapiens	167-172
28875744-0	2017	Folic acid-conjugated cationic Ag2S quantum dots for optical imaging and selective doxorubicin delivery to HeLa cells.	Folic Acid	0-10	angiotensin II receptor type 1	Homo sapiens	31-35
28875744-1	2017	AIM: We aim to develop folic acid (FA)-conjugated cationic Ag2S near-infrared quantum dots (NIRQDs) for the delivery of doxorubicin (DOX) selectively to folate receptor (FR)-positive cancer cells to achieve enhanced drug efficacy and optical tracking in the NIR region.	Folic Acid	23-33	angiotensin II receptor type 1	Homo sapiens	59-63
28767041-5	2017	A series of methods have demonstrated that per-thiol-beta-cyclodextrin (beta-CD-(SH)7) was successfully combined with HNTs via a redox-responsive disulfide bond, and folic acid-polyethylene glycol-adamantane (FA-PEG-Ad) was immobilized on the HNTs through the strong complexation between beta-CD/Ad.	Folic Acid	166-176	beta-carotene oxygenase 1	Mus musculus	72-79
28767041-5	2017	A series of methods have demonstrated that per-thiol-beta-cyclodextrin (beta-CD-(SH)7) was successfully combined with HNTs via a redox-responsive disulfide bond, and folic acid-polyethylene glycol-adamantane (FA-PEG-Ad) was immobilized on the HNTs through the strong complexation between beta-CD/Ad.	Folic Acid	166-176	beta-carotene oxygenase 1	Mus musculus	288-295
28658642-1	2017	The current study utilizes folic acid conjugated poly(styrene-co-maleic anhydride) block copolymer (FA-SMA) to enhance the solubility of a hydrophobic but very potent synthetic curcumin-difluorinated (CDF) analog and its targeted delivery to folate receptor-alpha overexpressing cancers.	Folic Acid	27-37	survival of motor neuron 1, telomeric	Homo sapiens	103-106
28592519-9	2017	Furthermore, mTORC1 and mTORC2 regulate trophoblast folate uptake by modulating the cell surface expression of folate receptor alpha and the reduced folate carrier.	Folic Acid	52-58	CREB regulated transcription coactivator 1	Mus musculus	13-19
28592519-9	2017	Furthermore, mTORC1 and mTORC2 regulate trophoblast folate uptake by modulating the cell surface expression of folate receptor alpha and the reduced folate carrier.	Folic Acid	52-58	CREB regulated transcription coactivator 2	Mus musculus	24-30
28592519-9	2017	Furthermore, mTORC1 and mTORC2 regulate trophoblast folate uptake by modulating the cell surface expression of folate receptor alpha and the reduced folate carrier.	Folic Acid	111-117	CREB regulated transcription coactivator 1	Mus musculus	13-19
28592519-9	2017	Furthermore, mTORC1 and mTORC2 regulate trophoblast folate uptake by modulating the cell surface expression of folate receptor alpha and the reduced folate carrier.	Folic Acid	111-117	CREB regulated transcription coactivator 2	Mus musculus	24-30
28592519-11	2017	Low maternal folate concentrations are linked to restricted fetal growth, and we propose that the underlying mechanisms involve trophoblast mTOR folate sensing resulting in inhibition of mTORC1 and mTORC2 and downregulation of placental amino acid transporters.	Folic Acid	145-151	CREB regulated transcription coactivator 1	Mus musculus	187-193
28592519-11	2017	Low maternal folate concentrations are linked to restricted fetal growth, and we propose that the underlying mechanisms involve trophoblast mTOR folate sensing resulting in inhibition of mTORC1 and mTORC2 and downregulation of placental amino acid transporters.	Folic Acid	145-151	CREB regulated transcription coactivator 2	Mus musculus	198-204
30618237-2	2019	The targeting molecules of folic acid (FA) are then conjugated to HNTs via reactions with bovine serum albumin (BSA).	Folic Acid	27-37	albumin	Mus musculus	97-110
30269276-9	2018	A positive correlation was found between folate concentration and expression of all genes, except MTHFD1L, in patients who received LV.	Folic Acid	41-47	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like	Homo sapiens	98-105
30247499-6	2018	Results: After adjusting for potential confounders, a statistically significant inverse association between serum folate concentration and at least grade 2 CIN (CIN2+) risk was observed (1st quartile compared with 4th quartile: OR = 1.40; 95% CI: 1.09, 1.79; P-trend &lt; 0.01); however, serum folate concentration was not associated with CIN1 risk.	Folic Acid	114-120	pyridoxal phosphatase	Homo sapiens	161-165
30247499-8	2018	An inverse linear relation between increased serum folate concentration and the risk of higher-grade CIN (CIN2, CIN3, and CIN2+) was also observed (for CIN2+: P-overall &lt; 0.01, P-nonlinearity = 0.96).	Folic Acid	51-57	pyridoxal phosphatase	Homo sapiens	106-110
30247499-8	2018	An inverse linear relation between increased serum folate concentration and the risk of higher-grade CIN (CIN2, CIN3, and CIN2+) was also observed (for CIN2+: P-overall &lt; 0.01, P-nonlinearity = 0.96).	Folic Acid	51-57	pyridoxal phosphatase	Homo sapiens	122-126
30247499-8	2018	An inverse linear relation between increased serum folate concentration and the risk of higher-grade CIN (CIN2, CIN3, and CIN2+) was also observed (for CIN2+: P-overall &lt; 0.01, P-nonlinearity = 0.96).	Folic Acid	51-57	pyridoxal phosphatase	Homo sapiens	122-126
30247499-9	2018	The highest risk of CIN2+ was observed in women with high-risk HPV types, who also had the lowest serum folate concentrations (P-interaction &lt; 0.01).	Folic Acid	104-110	pyridoxal phosphatase	Homo sapiens	20-24
28638480-0	2017	Mouse IP-10 Gene Delivered by Folate-modified Chitosan Nanoparticles and Dendritic/tumor Cells Fusion Vaccine Effectively Inhibit the Growth of Hepatocellular Carcinoma in Mice.	Folic Acid	30-36	chemokine (C-X-C motif) ligand 10	Mus musculus	6-11
29656957-2	2018	Additionally, PGA has the ability to activate mouse macrophages for the secretion of cytokines through Toll-like receptor (TLR) 2.	Folic Acid	14-17	toll-like receptor 2	Mus musculus	123-126
29656957-12	2018	Collectively, our results suggest that PGA and MDP cooperatively induce inflammatory responses in mouse DCs through TLR2 and NOD2 via MAP kinase and NF-kappaB pathways, subsequently leading to lymphocyte activation.	Folic Acid	39-42	toll-like receptor 2	Mus musculus	116-120
29656957-12	2018	Collectively, our results suggest that PGA and MDP cooperatively induce inflammatory responses in mouse DCs through TLR2 and NOD2 via MAP kinase and NF-kappaB pathways, subsequently leading to lymphocyte activation.	Folic Acid	39-42	nucleotide-binding oligomerization domain containing 2	Mus musculus	125-129
30213067-10	2018	Moreover, folic acid decreased the mRNA expression of TEAD1 and the protein expression of TEAD1 and YAP1.	Folic Acid	10-20	Yes1 associated transcriptional regulator	Homo sapiens	100-104
29928978-4	2018	The designed MTX loaded stearic acid-octa-arginine and folic acid decorated poly lactic-co-glycolic acid (PLGA) -PK3-based lipid polymeric hybrid nanoparticles (Sta-R8-FA-PPLPNs/MTX) were composed of PK3, Folate-PEG-PLGA, egg PC, and Sta-R8.	Folic Acid	55-65	pyruvate kinase M1/2	Rattus norvegicus	113-116
29928978-4	2018	The designed MTX loaded stearic acid-octa-arginine and folic acid decorated poly lactic-co-glycolic acid (PLGA) -PK3-based lipid polymeric hybrid nanoparticles (Sta-R8-FA-PPLPNs/MTX) were composed of PK3, Folate-PEG-PLGA, egg PC, and Sta-R8.	Folic Acid	55-65	pyruvate kinase M1/2	Rattus norvegicus	200-203
31826386-3	2019	This study aim to investigate whether betaine-homocysteine methyltransferase (BHMT) single-nucleotide polymorphisms (SNPs) and DNA methylation are related to the efficacy of folate therapy for HHcy and whether BHMT DNA methylation mediates the SNP-folate therapy efficacy association.	Folic Acid	174-180	betaine--homocysteine S-methyltransferase	Homo sapiens	78-82
31826386-6	2019	Finally, mediation analysis was performed to investigate whether DNA methylation of BHMT mediates the association between SNPs and folate therapy efficacy.	Folic Acid	131-137	betaine--homocysteine S-methyltransferase	Homo sapiens	84-88
31826386-7	2019	RESULTS: BHMT rs3733890 was significantly associated with folate therapy efficacy (p<0.05).	Folic Acid	58-64	betaine--homocysteine S-methyltransferase	Homo sapiens	9-13
31826386-10	2019	CONCLUSIONS: There has a consistent interrelationship among BHMT genetic variants, methylation levels of BHMT, and folate therapy efficacy.	Folic Acid	115-121	betaine--homocysteine S-methyltransferase	Homo sapiens	60-64
30360740-6	2019	METHODS: The blank folate-targeted liposomes composed of HSPC/DSPE-mPEG2000/DSPE-mPEG-Folic acid were prepared first by thin film hydration technique.	Folic Acid	19-25	proteasome 20S subunit alpha 7	Homo sapiens	57-61
30479216-5	2019	OBJECTIVE: In the present study, detailed computational analysis has been performed for PPAT protein, the key enzyme in de novo purine biosynthesis which is inhibited by many folate derivatives, hence we aimed to investigate and gauge the inhibitory effect of antifolate derivatives; lomexterol (LTX) methotrexate (LTX), and pipretixin (PTX) with human PPAT to effectively capture and inhibit De novo purine biosynthesis pathway.	Folic Acid	175-181	phosphoribosyl pyrophosphate amidotransferase	Homo sapiens	88-92
30479216-5	2019	OBJECTIVE: In the present study, detailed computational analysis has been performed for PPAT protein, the key enzyme in de novo purine biosynthesis which is inhibited by many folate derivatives, hence we aimed to investigate and gauge the inhibitory effect of antifolate derivatives; lomexterol (LTX) methotrexate (LTX), and pipretixin (PTX) with human PPAT to effectively capture and inhibit De novo purine biosynthesis pathway.	Folic Acid	175-181	phosphoribosyl pyrophosphate amidotransferase	Homo sapiens	353-357
30509972-4	2018	Many RFSs, as exemplified by expansion of a CGG trinucleotide repeat sequence in the fragile X syndrome-associated FRAXA locus, exhibit fragility in response to folate deficiency or other forms of "folate stress."	Folic Acid	161-167	fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)	Homo sapiens	115-120
30619878-5	2018	PGDH catalyzes the first step in the pathway by converting d-3-phosphoglycerate (PGA), an intermediate in glycolysis, to phosphohydroxypyruvate (PHP) concomitant with the reduction of NAD+.	Folic Acid	81-84	phosphoglycerate dehydrogenase	Homo sapiens	0-4
29953918-0	2018	Identification of three novel loci of ALDH2 Gene for Serum Folate levels in a Male Chinese Population by Genome-Wide Association Study.	Folic Acid	59-65	aldehyde dehydrogenase 2 family member	Homo sapiens	38-43
29953918-8	2018	Surprisingly, we discovered three novel loci rs3782886, rs671, and rs4646776 of ALDH2 gene were suggestively significantly associated with folate serum folate levels in the male population studied (P = 2.17 x 10-7, P = 3.60 x 10-7, P = 3.99 x 10-7, respectively) after adjusting for population stratification, BMI and age.	Folic Acid	139-145	aldehyde dehydrogenase 2 family member	Homo sapiens	80-85
29953918-8	2018	Surprisingly, we discovered three novel loci rs3782886, rs671, and rs4646776 of ALDH2 gene were suggestively significantly associated with folate serum folate levels in the male population studied (P = 2.17 x 10-7, P = 3.60 x 10-7, P = 3.99 x 10-7, respectively) after adjusting for population stratification, BMI and age.	Folic Acid	152-158	aldehyde dehydrogenase 2 family member	Homo sapiens	80-85
29953918-11	2018	CONCLUSION: In a male Chinese population, genome-wide association study discovered that three novel SNPs rs3782886, rs671 and rs4646776 of ALDH2 gene were suggestively significantly associated with serum folate levels.	Folic Acid	204-210	aldehyde dehydrogenase 2 family member	Homo sapiens	139-144
30337562-1	2018	AICARFT is a folate dependent catalytic site within the ATIC gene, part of the purine biosynthetic pathway, a pathway frequently upregulated in cancers.	Folic Acid	13-19	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	0-7
30337562-1	2018	AICARFT is a folate dependent catalytic site within the ATIC gene, part of the purine biosynthetic pathway, a pathway frequently upregulated in cancers.	Folic Acid	13-19	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	56-60
28588362-0	2017	Folic Acid Modulates Matrix Metalloproteinase-2 Expression, Alleviates Neuropathic Pain, and Improves Functional Recovery in Spinal Cord-Injured Rats.	Folic Acid	0-10	matrix metallopeptidase 2	Rattus norvegicus	21-47
27592453-0	2016	Folate deprivation induces cell cycle arrest at G0/G1 phase and apoptosis in hippocampal neuron cells through down-regulation of IGF-1 signaling pathway.	Folic Acid	0-6	insulin-like growth factor 1	Mus musculus	129-134
30024025-2	2018	Folate metabolism, which requires the enzyme methionine synthase reductase (MTRR), is necessary for DNA synthesis and the transmission of one-carbon methyl groups for cellular methylation.	Folic Acid	0-6	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Mus musculus	45-74
30094187-6	2018	GPI-APs function in vitamin-B6 and folate transport, nucleotide metabolism and lipid homeostasis.	Folic Acid	35-41	glucose-6-phosphate isomerase	Homo sapiens	0-3
29732722-10	2018	Eight more candidate genes (Abcc3, Gsr, Gclc, Mthfd1, Gart, Bche, Slc25a32, and Slc44a2) were identified by examining the DEGs of those genes involved in the extended folate metabolic pathway between FA-responsive and FA-resistant mutants.	Folic Acid	167-173	gutter shaped root	Mus musculus	35-38
29732722-10	2018	Eight more candidate genes (Abcc3, Gsr, Gclc, Mthfd1, Gart, Bche, Slc25a32, and Slc44a2) were identified by examining the DEGs of those genes involved in the extended folate metabolic pathway between FA-responsive and FA-resistant mutants.	Folic Acid	167-173	solute carrier family 44, member 2	Mus musculus	80-87
29930328-7	2018	Higher folate intake was associated with lower odds of high CACNA1G methylation among EAs but not AAs.	Folic Acid	7-13	calcium voltage-gated channel subunit alpha1 G	Homo sapiens	60-67
29685624-0	2018	Folic acid supplementation repressed hypoxia-induced inflammatory response via ROS and JAK2/STAT3 pathway in human promyelomonocytic cells.	Folic Acid	0-10	Janus kinase 2	Homo sapiens	87-91
29685624-6	2018	Folic acid targeted the activation of Janus kinase 2, downregulated the phosphorylation of signal transducer and activator of transcription 3, and decreased the expression of nuclear factor-kappaB p65 protein in cells.	Folic Acid	0-10	Janus kinase 2	Homo sapiens	38-52
29685624-6	2018	Folic acid targeted the activation of Janus kinase 2, downregulated the phosphorylation of signal transducer and activator of transcription 3, and decreased the expression of nuclear factor-kappaB p65 protein in cells.	Folic Acid	0-10	RELA proto-oncogene, NF-kB subunit	Homo sapiens	197-200
29685624-8	2018	In conclusion, folic acid efficiently inhibited the inflammatory response of THP-1 cells under hypoxic conditions by inhibiting reactive oxygen species production and the Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway.	Folic Acid	15-25	Janus kinase 2	Homo sapiens	171-185
29673352-4	2018	RESULTS: 200 nm aqueous probe Ag2S@DSPE-PEG2000-FA (Ag2S@DP-FA) with good dispersibility and stability was prepared by coating hydrophobic Ag2S with the mixture of folic acid (FA) modified DSPE-PEG2000 (DP) and other polymers, it was found the probe had good fluorescent, photoacoustic and photothermal responses, and a low cell cytotoxicity at 50 mug/mL Ag concentration.	Folic Acid	164-174	angiotensin II receptor type 1	Homo sapiens	30-34
29673352-4	2018	RESULTS: 200 nm aqueous probe Ag2S@DSPE-PEG2000-FA (Ag2S@DP-FA) with good dispersibility and stability was prepared by coating hydrophobic Ag2S with the mixture of folic acid (FA) modified DSPE-PEG2000 (DP) and other polymers, it was found the probe had good fluorescent, photoacoustic and photothermal responses, and a low cell cytotoxicity at 50 mug/mL Ag concentration.	Folic Acid	164-174	angiotensin II receptor type 1	Homo sapiens	52-56
29673352-4	2018	RESULTS: 200 nm aqueous probe Ag2S@DSPE-PEG2000-FA (Ag2S@DP-FA) with good dispersibility and stability was prepared by coating hydrophobic Ag2S with the mixture of folic acid (FA) modified DSPE-PEG2000 (DP) and other polymers, it was found the probe had good fluorescent, photoacoustic and photothermal responses, and a low cell cytotoxicity at 50 mug/mL Ag concentration.	Folic Acid	164-174	angiotensin II receptor type 1	Homo sapiens	52-56
29037729-6	2018	This new information on a plant FBP appears useful for metabolic engineering of a wide range of crops to enhance the content and stability of the folates during post-harvest storage.	Folic Acid	146-153	Inositol monophosphatase family protein	Arabidopsis thaliana	32-35
29139396-0	2018	Folic acid modified Pluronic F127 coating Ag2S quantum dot for photoacoustic imaging of tumor cell-targeting.	Folic Acid	0-10	angiotensin II receptor type 1	Homo sapiens	42-46
29139396-1	2018	In this study, an oil-soluble Ag2S quantum dot (QD) was synthesized through thermal decomposition using the single-source precursor method, and Pluronic F127 (PF127), a triblock copolymer functionalized with folic acid (FA), was deposited on the surface of the QD, then a water-soluble PF127-FA@Ag2S nanoprobe with targeting ability was fabricated.	Folic Acid	208-218	angiotensin II receptor type 1	Homo sapiens	30-34
30024025-2	2018	Folate metabolism, which requires the enzyme methionine synthase reductase (MTRR), is necessary for DNA synthesis and the transmission of one-carbon methyl groups for cellular methylation.	Folic Acid	0-6	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Mus musculus	76-80
30024025-9	2018	Methionine synthase reductase (MTRR) is a key enzyme necessary for the progression of folate metabolism since knocking down the Mtrr gene in mice results in hyperhomocysteinaemia and global DNA hypomethylation.	Folic Acid	86-92	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Mus musculus	0-29
30024025-9	2018	Methionine synthase reductase (MTRR) is a key enzyme necessary for the progression of folate metabolism since knocking down the Mtrr gene in mice results in hyperhomocysteinaemia and global DNA hypomethylation.	Folic Acid	86-92	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Mus musculus	31-35
30024025-9	2018	Methionine synthase reductase (MTRR) is a key enzyme necessary for the progression of folate metabolism since knocking down the Mtrr gene in mice results in hyperhomocysteinaemia and global DNA hypomethylation.	Folic Acid	86-92	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Mus musculus	128-132
30114345-2	2018	METHODS: Case-control study design was adopted to assess the role of folic acid, dietary habits, and homocysteine in relation to NTD births.	Folic Acid	69-79	fuzzy planar cell polarity protein	Homo sapiens	129-132
29345051-1	2018	The human solute carrier family 19 member 1 (SLC19A1) is the gene coding for reduced folate carrier 1 (RFC1).	Folic Acid	85-91	solute carrier family 19 member 1	Homo sapiens	10-43
29345051-1	2018	The human solute carrier family 19 member 1 (SLC19A1) is the gene coding for reduced folate carrier 1 (RFC1).	Folic Acid	85-91	solute carrier family 19 member 1	Homo sapiens	45-52
29486262-1	2018	In our previous study, we demonstrated that folate-appended methyl-beta-cyclodextrin (FA-M-beta-CyD) was a promising antitumor agent for the treatment of folate receptor-alpha (FR-alpha)-expressing tumors.	Folic Acid	44-50	cytochrome b-245, beta polypeptide	Mus musculus	96-99
29250709-6	2018	We showed that folic acid increased cell viability and decreased apoptosis in a dose-dependent manner, and that this effect was mediated by decreased caspase-3/7 activity, upregulated BCL2/BAX ratio, and downregulated TP53, CASP3, and CASP8 expressions.	Folic Acid	15-25	caspase 8	Homo sapiens	235-240
30038085-13	2018	It may be suggested that maternal decrease in vitamin B12, in mothers who have normal folic acid may be associated with NTD in their children.	Folic Acid	86-96	fuzzy planar cell polarity protein	Homo sapiens	120-123
29767673-5	2018	We applied existing models of the relation between RBC folate concentrations and NTD risk to predict NTD prevalence.	Folic Acid	55-61	fuzzy planar cell polarity protein	Homo sapiens	81-84
29767673-5	2018	We applied existing models of the relation between RBC folate concentrations and NTD risk to predict NTD prevalence.	Folic Acid	55-61	fuzzy planar cell polarity protein	Homo sapiens	101-104
29767673-6	2018	Results: Based on the distribution of overall RBC folate concentrations (4783 women), the predicted NTD prevalence was 7.3/10,000 live births [95% uncertainty interval (UI): 5.5-9.4/10,000 live births].	Folic Acid	50-56	fuzzy planar cell polarity protein	Homo sapiens	100-103
29767673-7	2018	Women consuming folic acid from ECGPs as their only source had lower usual daily total folic acid intakes (median: 115 microg/d; IQR: 79-156 microg/d), lower RBC folate concentrations (median: 881 nmol/L; IQR: 704-1108 nmol/L), and higher predicted NTD prevalence (8.5/10,000 live births; 95% UI: 6.4-10.8/10,000 live births) compared with women consuming additional folic acid from diet or supplements.	Folic Acid	16-26	fuzzy planar cell polarity protein	Homo sapiens	249-252
29767673-10	2018	Ensuring 400 microg/d intake of folic acid prior to pregnancy has the potential to increase the number of babies born without an NTD.	Folic Acid	32-42	fuzzy planar cell polarity protein	Homo sapiens	129-132
29171320-2	2018	Methylenetetrahydrofolate dehydrogenase 1-like (MTHFD1L) plays critical roles in folate cycle maintenance.	Folic Acid	19-25	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like	Homo sapiens	48-55
29588419-7	2018	Additionally, folic acid-induced AKI in mice resulted in increased expression of Fn14 and necroptosis mediators, such as receptor-interacting protein kinase 1 (RIPK1), RIPK3, and mixed lineage domain-like protein (MLKL).	Folic Acid	14-24	tumor necrosis factor receptor superfamily, member 12a	Mus musculus	81-85
31938300-11	2018	CONCLUSION: NaAsO2 induce embryonic cardiac defection and folate supplement alleviate this impairment through modulation of the Nkx2.5, GATA4 and TBX5 gene expression.	Folic Acid	58-64	T-box transcription factor 5	Rattus norvegicus	146-150
29659962-3	2018	Objective: We aimed to determine if the interaction of MTHFD1 synthetase deficiency and low folate intake increases developmental abnormalities in a mouse model for MTHFD1 R653Q.	Folic Acid	92-98	methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase	Mus musculus	165-171
29659962-11	2018	Conclusions: MTHFD1 synthetase-deficient mice are more sensitive to low folate intake than wild-type mice during pregnancy.	Folic Acid	72-78	methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase	Mus musculus	13-19
25755246-9	2016	This may contribute to a decrease in folate intake and therefore may contribute to an increase in NTD rates.	Folic Acid	37-43	fuzzy planar cell polarity protein	Homo sapiens	98-101
26561410-10	2016	CONCLUSIONS: Folate status was lower in the MTHFR 677TT and SLC19A1 80AA genotypes compared with corresponding reference genotypes.	Folic Acid	13-19	solute carrier family 19 member 1	Homo sapiens	60-67
25929994-8	2015	CONCLUSIONS: The present study indicates that coexpression of alphaGlcNAc and MUC6 in PGA suggests the presence of fully glycosylated MUC6 on tumour cells, consistent with pyloric gland differentiation.	Folic Acid	86-89	mucin 6, oligomeric mucus/gel-forming	Homo sapiens	78-82
25929994-8	2015	CONCLUSIONS: The present study indicates that coexpression of alphaGlcNAc and MUC6 in PGA suggests the presence of fully glycosylated MUC6 on tumour cells, consistent with pyloric gland differentiation.	Folic Acid	86-89	mucin 6, oligomeric mucus/gel-forming	Homo sapiens	134-138
25929994-9	2015	However, the decreased glycosylation of alphaGlcNAc on MUC6 is associated with high mitotic activity of tumour cells, indicative of malignant potential of PGA.	Folic Acid	155-158	mucin 6, oligomeric mucus/gel-forming	Homo sapiens	55-59
26400185-9	2015	Consistent with in vivo findings, 5-methyltetrahydrofolate (bioactive form of folate) restored phosphorylation (activation) of both AMPK and LKB1 in palmitic acid-treated HepG2 cells.	Folic Acid	52-58	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	132-136
26400185-10	2015	Activation of AMPK by folic acid might be responsible for AMPK-dependent phosphorylation of HMG-CoA reductase, leading to reduced hepatic cholesterol synthesis during high-fat diet feeding.	Folic Acid	22-32	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	14-18
26400185-10	2015	Activation of AMPK by folic acid might be responsible for AMPK-dependent phosphorylation of HMG-CoA reductase, leading to reduced hepatic cholesterol synthesis during high-fat diet feeding.	Folic Acid	22-32	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	58-62
26400185-11	2015	These results suggest that folic acid supplementation may improve cholesterol and glucose metabolism by restoration of AMPK activation in the liver.	Folic Acid	27-37	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	119-123
26365722-0	2015	A dendritic beta-galactosidase-responsive folate-monomethylauristatin E conjugate.	Folic Acid	42-48	galactosidase beta 1	Homo sapiens	12-30
26537450-7	2015	Folic acid attenuated the increase in subcellular reactive oxygen species (ROS) levels and oxidative adaptor p66Shc protein expression in parallel with the changes in GDF1 expression and cell viability.	Folic Acid	0-10	growth differentiation factor 1	Homo sapiens	167-171
26537450-9	2015	Our data demonstrated that folic acid supplementation protected against arsenic-mediated embryo toxicity by up-regulating the expression of Dvr1/GDF1, and folic acid enhanced the expression of GDF1 by decreasing p66Shc expression and subcellular ROS levels.	Folic Acid	27-37	growth differentiation factor 1	Homo sapiens	145-149
26537450-9	2015	Our data demonstrated that folic acid supplementation protected against arsenic-mediated embryo toxicity by up-regulating the expression of Dvr1/GDF1, and folic acid enhanced the expression of GDF1 by decreasing p66Shc expression and subcellular ROS levels.	Folic Acid	155-165	growth differentiation factor 1	Homo sapiens	193-197
26282096-4	2015	Furthermore, The PEG layer would detach from the NPs due to the up-regulated extracellular MMP2 and MMP9 in tumors, resulting in the exposure of folate to enhance the cellular internalization via folate receptor mediated endocytosis, which accelerated the release rate of CPT in vivo.	Folic Acid	145-151	matrix metallopeptidase 9	Mus musculus	100-104
25940848-2	2015	In this study, we developed a cyclodextrin (CD)-based novel carrier-drug conjugate, called per-FOL-beta-CD-ss-DOX, which has folic acid (FA) molecules at the end of primary hydroxyl groups of beta-CD and a pH-cleavable spacer with an anticancer drug, doxorubicin (DOX), at the end of secondary hydroxyl groups.	Folic Acid	125-135	beta-carotene oxygenase 1	Mus musculus	99-106
28639476-6	2018	The expressions of DNMT1 and GAP43, which were significantly upregulated in the IUGR group compared with the normal controls, were decreased with the folic acid intervention.	Folic Acid	150-160	growth associated protein 43	Rattus norvegicus	29-34
29447234-0	2018	Folic acid derived-P5779 mimetics regulate DAMP-mediated inflammation through disruption of HMGB1:TLR4:MD-2 axes.	Folic Acid	0-10	high mobility group box 1	Homo sapiens	92-97
29121255-12	2018	Among the 1CC genes, IR in vivo and proinflammatory gene expression in WAT were most strongly and inversely associated with SLC19A1, a gene encoding a membrane folate carrier.	Folic Acid	160-166	solute carrier family 19 member 1	Homo sapiens	124-131
29160908-7	2018	Additionally, in conditional CCN2 knockout mice, renal fibrosis elicited by folic acid-induced renal damage was prevented, and this was linked to inhibition of EGFR pathway activation.	Folic Acid	76-86	cellular communication network factor 2	Mus musculus	29-33
28185129-0	2018	Folic Acid Protects Against Glutamate-Induced Excitotoxicity in Hippocampal Slices Through a Mechanism that Implicates Inhibition of GSK-3beta and iNOS.	Folic Acid	0-10	glycogen synthase kinase 3 beta	Rattus norvegicus	133-142
28185129-5	2018	Moreover, hippocampal slices incubated with folic acid alone for 30 min presented increased phosphorylation of GSK-3beta at Ser9, indicating an inhibition of the activity of this enzyme.	Folic Acid	44-54	glycogen synthase kinase 3 beta	Rattus norvegicus	111-120
28185129-6	2018	Furthermore, folic acid in the presence of glutamate insult in hippocampal slices maintained for an additional period of 6 h in fresh culture medium without glutamate and/or folic acid induced phosphorylation of GSK-3beta and beta-catenin expression.	Folic Acid	13-23	glycogen synthase kinase 3 beta	Rattus norvegicus	212-221
28185129-8	2018	In conclusion, the results of this study show that the protective effect of folic acid against glutamate-induced excitotoxicity may involve the modulation of PI3K/GSK-3beta/beta-catenin pathway and iNOS inhibition.	Folic Acid	76-86	glycogen synthase kinase 3 beta	Rattus norvegicus	163-172
29139138-5	2018	We conclude with guidance on next steps to best navigate the road map toward the goal of generating reliable folate status data on which to assess NTD risk in WRA in low- and middle-income countries.	Folic Acid	109-115	fuzzy planar cell polarity protein	Homo sapiens	147-150
29042184-6	2018	The AICARFT site is capable of independently binding both nucleotide and folate substrates with high affinity however no evidence for positive cooperativity in binding could be detected using the model ligands employed in this study.	Folic Acid	73-79	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	4-11
29158184-7	2018	Delivery of Sox9 knockdown plasmid to the kidney by ultrasound microbubble-mediated gene transfer suppressed the unilateral ureteral obstruction (UUO) or folic acid-induced mouse renal fibrosis, whereas ectopic expression of Sox9 aggravated renal fibrosis.	Folic Acid	154-164	SRY (sex determining region Y)-box 9	Mus musculus	12-16
29109127-4	2018	The regulatory locus also expresses two functional RNAs, LINC00925-RNA and MIR9-3, which are coexpressed with POLG The MIR9-3 targets include NR2E1, a transcription factor maintaining neural stem cells in undifferentiated state, and MTHFD2, the regulatory enzyme of mitochondrial folate cycle, linking POLG expression to stem cell differentiation and folate metabolism.	Folic Acid	351-357	MIR9-3 host gene	Homo sapiens	57-66
29865064-7	2018	The incremental AbetaPP phosphorylation at Thr668 mediated by severe genetic-or diet-induced impairment of the folate cycle correlates with enhanced accumulation of demethylated protein phosphatase 2A (PP2A), and activation of glycogen synthase kinase-3beta (GSK-3beta).	Folic Acid	111-117	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	Mus musculus	186-200
29237753-10	2017	The number of Troy-derived cells increases after folic acid-induced injury.	Folic Acid	49-59	tumor necrosis factor receptor superfamily, member 19	Mus musculus	14-18
29125506-4	2017	After this and several other studies were conducted, the intake of 400 micrograms of folic acid per day, at least three months before and three months during pregnancy for prevention of NTD, was proposed [2,3,4].	Folic Acid	85-95	fuzzy planar cell polarity protein	Homo sapiens	186-189
29028357-3	2017	In the present study, we report the design and preclinical evaluation of folate-PEG12-NOTA-Al18F (1), a new folate-PET agent with improved potential for clinical applications.	Folic Acid	73-79	paternally expressed 12	Mus musculus	80-85
26276101-0	2015	Sex-specific dysregulation of cysteine oxidation and the methionine and folate cycles in female cystathionine gamma-lyase null mice: a serendipitous model of the methylfolate trap.	Folic Acid	72-78	cystathionase (cystathionine gamma-lyase)	Mus musculus	96-121
25841994-2	2015	Folates are B vitamins that, when taken up by cells through the Reduced Folate Carrier (RFC), are essential for normal cell growth and replication.	Folic Acid	0-7	solute carrier family 19 member 1	Homo sapiens	64-86
25841994-2	2015	Folates are B vitamins that, when taken up by cells through the Reduced Folate Carrier (RFC), are essential for normal cell growth and replication.	Folic Acid	0-7	solute carrier family 19 member 1	Homo sapiens	88-91
25808729-6	2015	RESULTS: In the high NTD prevalence population, plasma folate concentration increased to 33.4 (18.7, 58.4) nmol/L in the postprogram sample, which is 2.9 times of the preprogram.	Folic Acid	55-61	fuzzy planar cell polarity protein	Homo sapiens	21-24
25808729-7	2015	In the low NTD prevalence population, plasma folate increased to 67.9 (44.5, 101.9) nmol/L, which is 1.9 times of the preprogram.	Folic Acid	45-51	fuzzy planar cell polarity protein	Homo sapiens	11-14
25808729-11	2015	CONCLUSION: Plasma folate levels among pregnant Chinese women increased dramatically after the nation-wide folic acid supplementation program in both rural and urban areas, and in populations of high and low NTD prevalence.	Folic Acid	19-25	fuzzy planar cell polarity protein	Homo sapiens	208-211
26027741-8	2015	Heritable genetic variants in the ABC and SLC transport pathways; in the CYP450, GST, and UGT-mediated phase I and II metabolism; in the folate metabolic pathway; as well as in the EGF and VEGF signaling pathways, have been associated with a distinct tumor sensitivity phenotype in CRC patients treated with fluoropyrimidines combined with either irinotecan, oxaliplatin or targeted biological agents.	Folic Acid	137-143	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	34-37
26027741-8	2015	Heritable genetic variants in the ABC and SLC transport pathways; in the CYP450, GST, and UGT-mediated phase I and II metabolism; in the folate metabolic pathway; as well as in the EGF and VEGF signaling pathways, have been associated with a distinct tumor sensitivity phenotype in CRC patients treated with fluoropyrimidines combined with either irinotecan, oxaliplatin or targeted biological agents.	Folic Acid	137-143	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	90-93
25728832-2	2015	The current study examined folate metabolism as a potential mechanism of CVD and neurocognitive deficits by: 1) using endothelial dysfunction as a biomarker of CVD, and 2) comparing enzymes associated with neurocognition, CVD, and critical to folate metabolism, methylenetetrahydrofolate reductase (MTHFR) and catechol-o-methyl transferase (COMT).	Folic Acid	27-33	catechol-O-methyltransferase	Homo sapiens	310-339
25728832-2	2015	The current study examined folate metabolism as a potential mechanism of CVD and neurocognitive deficits by: 1) using endothelial dysfunction as a biomarker of CVD, and 2) comparing enzymes associated with neurocognition, CVD, and critical to folate metabolism, methylenetetrahydrofolate reductase (MTHFR) and catechol-o-methyl transferase (COMT).	Folic Acid	27-33	catechol-O-methyltransferase	Homo sapiens	341-345
28735004-2	2017	Thermodynamic analysis DeltaH -14 to -10 (KJMol-1) and DeltaS 14 to -1 (JMol-1, K-1) showed tRNA-folic acid-chitosan bindings occur via H-bonding, hydrophobic and van der Waals contacts.	Folic Acid	97-107	keratin 1	Homo sapiens	80-83
28780092-9	2017	Hepatic gene expression of methylmalonyl-CoA mutase and S-adenosylhomocysteine hydrolase was higher for cows receiving the combined folic acid and vitamin B12 supplement compared with cows receiving only the supplement of folic acid, whereas no treatment effect was noted for cows not receiving the folic acid supplement.	Folic Acid	132-142	adenosylhomocysteinase	Bos taurus	56-88
28780092-9	2017	Hepatic gene expression of methylmalonyl-CoA mutase and S-adenosylhomocysteine hydrolase was higher for cows receiving the combined folic acid and vitamin B12 supplement compared with cows receiving only the supplement of folic acid, whereas no treatment effect was noted for cows not receiving the folic acid supplement.	Folic Acid	222-232	adenosylhomocysteinase	Bos taurus	56-88
28780092-9	2017	Hepatic gene expression of methylmalonyl-CoA mutase and S-adenosylhomocysteine hydrolase was higher for cows receiving the combined folic acid and vitamin B12 supplement compared with cows receiving only the supplement of folic acid, whereas no treatment effect was noted for cows not receiving the folic acid supplement.	Folic Acid	222-232	adenosylhomocysteinase	Bos taurus	56-88
27534418-0	2017	Late Maternal Folate Supplementation Rescues from Methyl Donor Deficiency-Associated Brain Defects by Restoring Let-7 and miR-34 Pathways.	Folic Acid	14-20	microRNA 34a	Homo sapiens	122-128
25522298-2	2015	Folic acid and tumor microenvironment-sensitive polypeptide (TMSP) co-modified lipid-nanocarrier (F/TMSP-NLC) are successfully formulated in response to the overexpression of folate receptor (FR) and the upregulation of matrix metalloproteinase-2 (MMP-2) in tumor microenvironment.	Folic Acid	0-10	matrix metallopeptidase 2	Homo sapiens	220-246
25522298-2	2015	Folic acid and tumor microenvironment-sensitive polypeptide (TMSP) co-modified lipid-nanocarrier (F/TMSP-NLC) are successfully formulated in response to the overexpression of folate receptor (FR) and the upregulation of matrix metalloproteinase-2 (MMP-2) in tumor microenvironment.	Folic Acid	0-10	matrix metallopeptidase 2	Homo sapiens	248-253
25975556-1	2015	OBJECTIVE: To explore the interaction between folate deficiency and aberrant expression related to fragile histidine triad (FHIT) gene in the progression of cervical cancerization.	Folic Acid	46-52	fragile histidine triad diadenosine triphosphatase	Homo sapiens	124-128
25975556-12	2015	In vitro, both rates related to proliferation inhibition (r = 0.98, P &lt; 0.001) and apoptosis (r = 0.99, P &lt; 0.001) together with the levels of FHIT protein expression (r = 0.97, P &lt; 0.001) were all increased gradually with the increase of folate concentration while the methylation status of FHIT gene CpG islands all changed from positive to negative gradually.	Folic Acid	248-254	fragile histidine triad diadenosine triphosphatase	Homo sapiens	149-153
25444929-2	2015	In order to further characterize the functional role of HSC70 in regulating MTX resistance in L1210 cells, we first showed that HSC70 colocalizes and interacts with reduced folate carrier (RFC) in L1210 cells by confocal laser scanning microscopy and Duolink in situ proximity ligation assay.	Folic Acid	173-179	heat shock protein 8	Mus musculus	56-61
25444929-2	2015	In order to further characterize the functional role of HSC70 in regulating MTX resistance in L1210 cells, we first showed that HSC70 colocalizes and interacts with reduced folate carrier (RFC) in L1210 cells by confocal laser scanning microscopy and Duolink in situ proximity ligation assay.	Folic Acid	173-179	heat shock protein 8	Mus musculus	128-133
25608940-1	2015	We determined whether ring-2 carbon of histidine is folate-dependently transferred to carbons 8 (C8) and/or 2 (C2) in urinary uric acid in humans.	Folic Acid	52-58	ring finger protein 2	Homo sapiens	22-28
26610311-7	2015	The objective of this study was to select the optimal producing yeast strain by determining the differences in nucleotide sequences in the FOL2, FOL3 and DFR1 genes of folic acid biosynthesis pathway.	Folic Acid	168-178	GTP cyclohydrolase I	Saccharomyces cerevisiae S288C	139-143
25059538-10	2015	We demonstrate association of the low HbA2 level with vitamin B12 and folate deficiency in this cohort.	Folic Acid	70-76	hemoglobin subunit alpha 2	Homo sapiens	38-42
25203609-3	2015	When fluorescent-labeled folic acid was intravenously injected into mice bearing FR-positive human nasopharyngeal tumor KB, and FR-negative human prostate tumor PC-3 and mouse colon adenocarcinoma Colon 26, fluorescence was strongly detected in KB and Colon 26 tumors, and moderately in PC-3 tumor, indicating that folic acid was taken up by TAMs via FRbeta in PC-3 and Colon 26 tumors.	Folic Acid	25-35	folate receptor 2 (fetal)	Mus musculus	351-357
25474351-10	2014	Another example was SNP rs1800588 near LIPC, significantly associated with the novel phenotypes of folate levels (Mexican Americans), vitamin E levels (non-Hispanic whites) and triglyceride levels (non-Hispanic whites), and replication for cholesterol levels.	Folic Acid	99-105	lipase C, hepatic type	Homo sapiens	39-43
27534418-9	2017	While folic acid supplementation helped restoring the levels of let-7a and miR-34a and their downstream targets, it led to a reduction of structural and functional defects taking place during the perinatal period.	Folic Acid	6-16	microRNA 34a	Homo sapiens	75-82
28855807-5	2017	In this present study, three components of GART enzyme were targeted as receptor dataset and in silico analysis was carried out with folate ligand dataset.	Folic Acid	133-139	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	Homo sapiens	43-47
28559181-1	2017	The MTHFD1 gene encodes for methylenetetrahydrofolate dehydrogenase 1, an enzyme that has an important role in folate-mediated one-carbon metabolism.	Folic Acid	47-53	methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase	Mus musculus	4-10
28559181-3	2017	Mice homozygous for a loss of Mthfd1 via a gene-trap mutation are not viable, and heterozygotes, though they appear healthy, have metabolic imbalances in the folate- and choline-mediated 1-carbon metabolic pathways.	Folic Acid	158-164	methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase	Mus musculus	30-36
28786938-9	2017	After 13 weeks in low folate, an increase in the phosphorylation of the histone H2AX was noted, indicative of an accumulation of DNA double strand breaks.	Folic Acid	22-28	H2A.X variant histone	Homo sapiens	72-84
28534241-3	2017	Genome-wide association studies (GWAS) revealed that human folate level could be significantly influenced by fidgetin (FIGN), methylenetetrahydrofolate reductase (MTHFR), prickle homolog 2 (PRICKLE2), synaptotagmin 9 (SYT9), gamma-aminobutyric acid B receptor 2 (GABBR2), and alkaline phosphatase (ALPL) genes.	Folic Acid	59-65	synaptotagmin 9	Homo sapiens	201-216
28534241-3	2017	Genome-wide association studies (GWAS) revealed that human folate level could be significantly influenced by fidgetin (FIGN), methylenetetrahydrofolate reductase (MTHFR), prickle homolog 2 (PRICKLE2), synaptotagmin 9 (SYT9), gamma-aminobutyric acid B receptor 2 (GABBR2), and alkaline phosphatase (ALPL) genes.	Folic Acid	59-65	synaptotagmin 9	Homo sapiens	218-222
28534241-3	2017	Genome-wide association studies (GWAS) revealed that human folate level could be significantly influenced by fidgetin (FIGN), methylenetetrahydrofolate reductase (MTHFR), prickle homolog 2 (PRICKLE2), synaptotagmin 9 (SYT9), gamma-aminobutyric acid B receptor 2 (GABBR2), and alkaline phosphatase (ALPL) genes.	Folic Acid	59-65	gamma-aminobutyric acid type B receptor subunit 2	Homo sapiens	225-261
28534241-3	2017	Genome-wide association studies (GWAS) revealed that human folate level could be significantly influenced by fidgetin (FIGN), methylenetetrahydrofolate reductase (MTHFR), prickle homolog 2 (PRICKLE2), synaptotagmin 9 (SYT9), gamma-aminobutyric acid B receptor 2 (GABBR2), and alkaline phosphatase (ALPL) genes.	Folic Acid	59-65	gamma-aminobutyric acid type B receptor subunit 2	Homo sapiens	263-269
28534241-3	2017	Genome-wide association studies (GWAS) revealed that human folate level could be significantly influenced by fidgetin (FIGN), methylenetetrahydrofolate reductase (MTHFR), prickle homolog 2 (PRICKLE2), synaptotagmin 9 (SYT9), gamma-aminobutyric acid B receptor 2 (GABBR2), and alkaline phosphatase (ALPL) genes.	Folic Acid	59-65	alkaline phosphatase, biomineralization associated	Homo sapiens	298-302
28627503-5	2017	Here we provide a strategy using three-layered polyplex with folic acid as a targeting group to systemically deliver miR-210 into breast cancer cells, which results in breast cancer growth being inhibited.	Folic Acid	61-71	microRNA 210	Homo sapiens	117-124
28526947-2	2017	We attempted to explore the relationship of UC with transcobalamin II (TCN2) gene polymorphisms and serum homocysteine, vitamin B12, and folate levels in Chinese patients.	Folic Acid	137-143	transcobalamin 2	Homo sapiens	52-69
28697225-3	2017	Though vitiligo is an autoimmune disease, there is no current data to support systemic immunosuppressive monotherapy.&lt;/p&gt; &lt;p&gt;CASE SUMMARY: Here we present a case series of 3 patients with vitiligo treated for 11-16 months with low-dose methotrexate (12.5-25 mg per week) with folic acid supplementation with clinically significant skin repigmentation, with response within 6 months in one case.	Folic Acid	288-298	VAMAS6	Homo sapiens	7-15
28374905-15	2017	In addition, we demonstrate that maternal serum folate is positively correlated to placental mTORC1 and mTORC2 signalling activity in human pregnancy.	Folic Acid	48-54	CREB regulated transcription coactivator 1	Mus musculus	93-99
28374905-15	2017	In addition, we demonstrate that maternal serum folate is positively correlated to placental mTORC1 and mTORC2 signalling activity in human pregnancy.	Folic Acid	48-54	CREB regulated transcription coactivator 2	Mus musculus	104-110
28350247-1	2017	Dihydrofolate reductase (DHFR) reduces folic acid and recycles dihydrofolate generated during dTMP biosynthesis to tetrahydrofolate.	Folic Acid	39-49	dihydrofolate reductase	Danio rerio	0-23
28350247-1	2017	Dihydrofolate reductase (DHFR) reduces folic acid and recycles dihydrofolate generated during dTMP biosynthesis to tetrahydrofolate.	Folic Acid	39-49	dihydrofolate reductase	Danio rerio	25-29
32153822-11	2017	Children who didn"t take folic acid supplement had 65% lower probability of recovery from SAM compared to children who took folic acid supplement (AHR = 0.35, 95% CI: 0.14-0.89).	Folic Acid	124-134	aryl hydrocarbon receptor	Homo sapiens	147-150
28420213-3	2017	For this purpose, amphiphilic poly(styrene-co-maleic acid)-conjugated-folic acid (SMA-FA) was synthesized and utilized to improve the aqueous solubility of a highly hydrophobic, but very potent anticancer compound, CDF, and its targeted delivery to folate overexpressing cancers.	Folic Acid	70-80	survival of motor neuron 1, telomeric	Homo sapiens	82-85
28420213-3	2017	For this purpose, amphiphilic poly(styrene-co-maleic acid)-conjugated-folic acid (SMA-FA) was synthesized and utilized to improve the aqueous solubility of a highly hydrophobic, but very potent anticancer compound, CDF, and its targeted delivery to folate overexpressing cancers.	Folic Acid	249-255	survival of motor neuron 1, telomeric	Homo sapiens	82-85
28420213-13	2017	In conclusion, the folic acid-conjugated SMA loaded with CDF showed promising potential with high safety and pronounced anticancer activity on the tested retinoblastoma cell lines.	Folic Acid	19-29	survival of motor neuron 1, telomeric	Homo sapiens	41-44
28291364-6	2017	The uptake of R7/PSD-Fol NPs was visualized by using the fluorescence of Rh-123 to detect the targeting effect of folate on the surface of R7/PSD-Fol NPs.	Folic Acid	114-120	CD1c molecule	Homo sapiens	14-16
28291364-6	2017	The uptake of R7/PSD-Fol NPs was visualized by using the fluorescence of Rh-123 to detect the targeting effect of folate on the surface of R7/PSD-Fol NPs.	Folic Acid	114-120	CD1c molecule	Homo sapiens	139-141
28259896-4	2017	In the folate cycle, glycine and serine fuel the mitochondrial enzymes SHMT2, MTHFD2 and ALDH1L2, which play critical roles in the cancer survival and proliferation presumably through purine production.	Folic Acid	7-13	aldehyde dehydrogenase 1 family member L2	Homo sapiens	89-96
28540268-0	2017	Effects of High and Low Doses of Folic Acid on the Soluble Receptor Activator of Nuclear Factor-kappa B Ligand/Osteoprotegerin Ratio during Pregnancy.	Folic Acid	33-43	TNF receptor superfamily member 11b	Homo sapiens	111-126
28540268-2	2017	Soluble Receptor Activator of Nuclear Factor-Kappa B ligand (sRANKL) to Osteoprotegerin (OPG) ratio is chosen as a bone metabolism equation in many bone diseases characterized by bone resorption, such as post-menopausal osteoporosis and would be modified with folic acid supplementation.	Folic Acid	260-270	TNF receptor superfamily member 11b	Homo sapiens	72-87
28540268-2	2017	Soluble Receptor Activator of Nuclear Factor-Kappa B ligand (sRANKL) to Osteoprotegerin (OPG) ratio is chosen as a bone metabolism equation in many bone diseases characterized by bone resorption, such as post-menopausal osteoporosis and would be modified with folic acid supplementation.	Folic Acid	260-270	TNF receptor superfamily member 11b	Homo sapiens	89-92
28540268-3	2017	This study was done to compare the effects of high dose (5mg/day) and low dose (0.5 mg/day) folic acid in the RANKL/OPG ratio and Tumor Necrosis Factoralpha (TNFalpha) concentration during pregnancy.	Folic Acid	92-102	TNF receptor superfamily member 11b	Homo sapiens	116-119
28540268-7	2017	RESULTS: OPG levels were significantly higher compared with the baseline value (P=0.008), although sRANKL (P&lt;0.001), TNFalpha (P=0.005) and sRANKL/OPG ratio (P&lt;0.001) reduced significantly with high dose of folic acid supplementation.	Folic Acid	213-223	TNF receptor superfamily member 11b	Homo sapiens	9-12
28540268-9	2017	CONCLUSION: High dose of folic acid supplementation could decrease bone resorptive biomarkers and may prevent PAO in pregnant women by increasing OPG and decreasing sRANKL and TNFalpha.	Folic Acid	25-35	TNF receptor superfamily member 11b	Homo sapiens	146-149
28228507-2	2017	Folate-independent pathways are mediated by cytosolic alcohol dehydrogenase 5 (ADH5) and mitochondrial aldehyde dehydrogenase 2 (ALDH2), which generate formate by oxidizing formaldehyde.	Folic Acid	0-6	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	54-77
28228507-2	2017	Folate-independent pathways are mediated by cytosolic alcohol dehydrogenase 5 (ADH5) and mitochondrial aldehyde dehydrogenase 2 (ALDH2), which generate formate by oxidizing formaldehyde.	Folic Acid	0-6	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	79-83
28228507-2	2017	Folate-independent pathways are mediated by cytosolic alcohol dehydrogenase 5 (ADH5) and mitochondrial aldehyde dehydrogenase 2 (ALDH2), which generate formate by oxidizing formaldehyde.	Folic Acid	0-6	aldehyde dehydrogenase 2 family member	Homo sapiens	129-134
28407838-13	2017	The methylation levels of IGF-1R, IGF-2R, IGFBP-2, IGFBP-5, IGFBP-6 and IGFBP-7 in the fetal brain were higher in the folate deficient group than in the control group (P&lt;0.05).	Folic Acid	118-124	insulin-like growth factor 1 receptor	Rattus norvegicus	26-32
28407838-13	2017	The methylation levels of IGF-1R, IGF-2R, IGFBP-2, IGFBP-5, IGFBP-6 and IGFBP-7 in the fetal brain were higher in the folate deficient group than in the control group (P&lt;0.05).	Folic Acid	118-124	insulin-like growth factor binding protein 7	Rattus norvegicus	72-79
28407838-14	2017	The methylation levels of IGF-1R, IGF-2R, IGFBP-3 and IGFBP-5 in the fetal liver were higher in the folate deficient group than in the control group.	Folic Acid	100-106	insulin-like growth factor 1 receptor	Rattus norvegicus	26-32
28008233-2	2016	A pH-responsive, active targeting delivery system was designed using folic acid functionalized amphiphilic alternating copolymer poly(styrene-alt-maleic anhydride) (FA-DABA-SMA) via a biodegradable linker 2,4-diaminobutyric acid (DABA).	Folic Acid	69-79	survival of motor neuron 1, telomeric	Homo sapiens	173-176
27669293-8	2016	In addition, folic acid induced PPARgamma expression and triglyceride accumulation in 3T3-L1 cells.	Folic Acid	13-23	peroxisome proliferator activated receptor gamma	Mus musculus	32-41
27149557-2	2016	The influence of folate levels on the FoxP3 expression in Treg (regulatory T) cells in the studied children, taking into account the MTHFR (5,10-methylenetetrahydrofolate reductase) genotypes was also analyzed.	Folic Acid	17-23	forkhead box P3	Homo sapiens	38-43
27149557-8	2016	A negative correlation was demonstrated between the FoxP3 expression in CD4+CD25highFoxP3+ peripheral blood lymphocytes and serum folic acid concentrations.	Folic Acid	130-140	forkhead box P3	Homo sapiens	52-57
27562465-4	2016	We used cultured primary human trophoblast cells to test the hypothesis that mechanistic target of rapamycin complex 1 (mTORC1) and 2 (mTORC2) regulate folate transport by post-translational mechanisms.	Folic Acid	152-158	CREB regulated transcription coactivator 1	Mus musculus	120-126
27562465-4	2016	We used cultured primary human trophoblast cells to test the hypothesis that mechanistic target of rapamycin complex 1 (mTORC1) and 2 (mTORC2) regulate folate transport by post-translational mechanisms.	Folic Acid	152-158	CREB regulated transcription coactivator 2	Mus musculus	135-141
27562465-5	2016	Silencing raptor (inhibits mTORC1) or rictor (inhibits mTORC2) markedly decreased basal folate uptake.	Folic Acid	88-94	CREB regulated transcription coactivator 1	Mus musculus	27-33
27562465-5	2016	Silencing raptor (inhibits mTORC1) or rictor (inhibits mTORC2) markedly decreased basal folate uptake.	Folic Acid	88-94	CREB regulated transcription coactivator 2	Mus musculus	55-61
27562465-6	2016	Folate uptake stimulated by insulin + IGF-1 was mediated by mTORC2 but did not involve mTORC1.	Folic Acid	0-6	CREB regulated transcription coactivator 2	Mus musculus	60-66
27562465-9	2016	In conclusion, we report for the first time that mTORC1/C2 are positive regulators of cellular folate uptake by modulating the cell surface abundance of specific transporter isoforms.	Folic Acid	95-101	CREB regulated transcription coactivator 1	Mus musculus	49-55
27302066-1	2016	Our previous study suggested that ceramide synthase 6 (CerS6), an enzyme in sphingolipid biosynthesis, is regulated by p53: CerS6 was elevated in several cell lines in response to transient expression of p53 or in response to folate stress, which is known to activate p53.	Folic Acid	226-232	ceramide synthase 6	Homo sapiens	34-53
27547186-11	2016	In conclusion, certain genetic polymorphisms related to the folate transport pathway, particularly COL18A1 rs2274808, SLC19A1 rs2838956, ABCB1 rs1045642, and ABCC5 rs3792585, were associated with an increased risk for ALL in Mexican children.	Folic Acid	60-66	solute carrier family 19 member 1	Homo sapiens	118-125
27547186-11	2016	In conclusion, certain genetic polymorphisms related to the folate transport pathway, particularly COL18A1 rs2274808, SLC19A1 rs2838956, ABCB1 rs1045642, and ABCC5 rs3792585, were associated with an increased risk for ALL in Mexican children.	Folic Acid	60-66	ATP binding cassette subfamily C member 5	Homo sapiens	158-163
27213918-5	2016	We presently found that CUL3 down-regulation could rescue folate deprivation-induced MAT IIalpha exhaustion and growth arrest in colorectal cancer (CRC) cells.	Folic Acid	58-64	cullin 3	Homo sapiens	24-28
27322259-0	2016	Benzbromarone, Quercetin, and Folic Acid Inhibit Amylin Aggregation.	Folic Acid	30-40	islet amyloid polypeptide	Homo sapiens	49-55
27322259-4	2016	Interestingly, three of the compounds analyzed-benzbromarone, quercetin, and folic acid-are able to slow down amylin fiber formation according to Thioflavin T binding, turbidimetry, and Transmission Electron Microscopy assays.	Folic Acid	77-87	islet amyloid polypeptide	Homo sapiens	110-116
26906511-14	2016	Taken together, the results suggested that hypoxia decreased the cell survival rate and induced apoptosis via ERK1/2/NOX4/ROS pathway, which could be the target of folic acid in protecting the HUVECs from injury caused by hypoxia.	Folic Acid	164-174	NADPH oxidase 4	Homo sapiens	117-121
27313708-0	2016	Low folate levels are associated with methylation-mediated transcriptional repression of miR-203 and miR-375 during cervical carcinogenesis.	Folic Acid	4-10	microRNA 203a	Homo sapiens	89-96
27313708-1	2016	The aim of the present study was to investigate the correlation between a lack of folic acid and the abnormal expression of microRNA (miR)-203 and miR-375 in cervical cancer.	Folic Acid	82-92	microRNA 203a	Homo sapiens	124-142
27313708-8	2016	In CaSki cells, as the concentration of folic acid increased, the positive rate of DNA methylation of miR-203 and miR-375 decreased, while the expression levels of miR-203 and miR-375 demonstrated a gradual increase, which indicated that the latter two parameters were negatively correlated (P&lt;0.05).	Folic Acid	40-50	microRNA 203a	Homo sapiens	102-109
27313708-8	2016	In CaSki cells, as the concentration of folic acid increased, the positive rate of DNA methylation of miR-203 and miR-375 decreased, while the expression levels of miR-203 and miR-375 demonstrated a gradual increase, which indicated that the latter two parameters were negatively correlated (P&lt;0.05).	Folic Acid	40-50	microRNA 203a	Homo sapiens	164-171
27313708-11	2016	Therefore, reduced levels of folic acid, leading to increased methylation of miR-203 and miR-375, may be significant events during cervical carcinogenesis.	Folic Acid	29-39	microRNA 203a	Homo sapiens	77-84
29434897-5	2018	The aim of the present study was to evaluate the influences of folate on FHIT gene methylation and expression in the progression of cervical cancerization.	Folic Acid	63-69	fragile histidine triad diadenosine triphosphatase	Homo sapiens	73-77
29434897-11	2018	The results indicated that folate was able to enhance apoptosis and inhibit the cervical cell proliferation while regulating FHIT gene methylation and expression.	Folic Acid	27-33	fragile histidine triad diadenosine triphosphatase	Homo sapiens	125-129
29461227-2	2018	The folate metabolism violation and hyperhomocysteinemia in women are proved to be the leading risk factors for the NTD of the fetus.	Folic Acid	4-10	fuzzy planar cell polarity protein	Homo sapiens	116-119
29461227-5	2018	The aim of the study is to develop an algorithm for the identification of women of reproductive age with the risk of having a child with NTD and to apply differentiated approach to the choice of a preventive dose of folic acid.	Folic Acid	216-226	fuzzy planar cell polarity protein	Homo sapiens	137-140
29461227-11	2018	The mothers of children with NTD showed a decreased level of folic acid and an increased level of homocysteine in addition to the correlation of hyperhomocysteinemia with the mutations of the MTHFR gene.	Folic Acid	61-71	fuzzy planar cell polarity protein	Homo sapiens	29-32
28631291-7	2017	Among the findings, there was a significant association between folic acid concentration and hsa-let-7 g methylation level in NTD cases.	Folic Acid	64-74	fuzzy planar cell polarity protein	Homo sapiens	126-129
29141214-4	2017	Similarly, the inability to use glycine as a one-carbon donor to the folate cycle causes NTDs in glycine decarboxylase (Gldc)-deficient embryos.	Folic Acid	69-75	glycine decarboxylase	Homo sapiens	120-124
28906345-6	2017	In conclusion, the results showed that folic acid significantly improved depression-like behaviors in CUMS-induced rats, and its antidepressant effects might be related to the increase of brain 5-HT concentration, BDNF and GluR1 expression, and repair of synaptic organization in the brain.	Folic Acid	39-49	POU class 6 homeobox 1	Rattus norvegicus	188-195
28885847-2	2017	Folate transport in mammalian tissues is mediated by three major folate transport systems, i.e., reduced folate carrier (RFC), proton-coupled folate transporter (PCFT), and folate receptor alpha (FRalpha), known to be regulated by ligand-activated nuclear receptors, such as vitamin D receptor (VDR).	Folic Acid	0-6	solute carrier family 19 member 1	Homo sapiens	97-119
28885847-2	2017	Folate transport in mammalian tissues is mediated by three major folate transport systems, i.e., reduced folate carrier (RFC), proton-coupled folate transporter (PCFT), and folate receptor alpha (FRalpha), known to be regulated by ligand-activated nuclear receptors, such as vitamin D receptor (VDR).	Folic Acid	0-6	solute carrier family 19 member 1	Homo sapiens	121-124
28885847-2	2017	Folate transport in mammalian tissues is mediated by three major folate transport systems, i.e., reduced folate carrier (RFC), proton-coupled folate transporter (PCFT), and folate receptor alpha (FRalpha), known to be regulated by ligand-activated nuclear receptors, such as vitamin D receptor (VDR).	Folic Acid	65-71	solute carrier family 19 member 1	Homo sapiens	97-119
28885847-5	2017	The objective of this study was to investigate the role of RFC in folate uptake at the level of the blood-brain barrier (BBB) and its potential regulation by VDR.	Folic Acid	66-72	solute carrier family 19 member 1	Homo sapiens	59-62
29492317-5	2017	The enzyme methionine synthase reductase (MTRR) is required for the progression of folate metabolism and the utilization of methyl groups from the folate cycle.	Folic Acid	83-89	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Mus musculus	11-40
29492317-5	2017	The enzyme methionine synthase reductase (MTRR) is required for the progression of folate metabolism and the utilization of methyl groups from the folate cycle.	Folic Acid	83-89	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Mus musculus	42-46
29492317-5	2017	The enzyme methionine synthase reductase (MTRR) is required for the progression of folate metabolism and the utilization of methyl groups from the folate cycle.	Folic Acid	147-153	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Mus musculus	11-40
29492317-5	2017	The enzyme methionine synthase reductase (MTRR) is required for the progression of folate metabolism and the utilization of methyl groups from the folate cycle.	Folic Acid	147-153	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Mus musculus	42-46
28944587-3	2017	Human NTD incidence has fallen by 35-50% in North America due to mandatory folic acid fortification of enriched cereal grain products since 1998.	Folic Acid	75-85	fuzzy planar cell polarity protein	Homo sapiens	6-9
28891336-3	2017	Folic acid (FA)-conjugated PUFA-based lipid nanoparticles (FA-PLN/DTX) was developed.	Folic Acid	0-10	phospholamban	Homo sapiens	62-65
28592519-7	2017	In addition, folate deficiency in primary human trophoblast (PHT) cells resulted in inhibition of mTORC1 and mTORC2 signaling and decreased the activity of key amino acid transporters.	Folic Acid	13-19	CREB regulated transcription coactivator 1	Mus musculus	98-104
28592519-7	2017	In addition, folate deficiency in primary human trophoblast (PHT) cells resulted in inhibition of mTORC1 and mTORC2 signaling and decreased the activity of key amino acid transporters.	Folic Acid	13-19	CREB regulated transcription coactivator 2	Mus musculus	109-115
28603098-8	2017	The decrease trend in alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were stronger in the folic acid group compared to silymarin group (P=0.04 and P=0.007, respectively).	Folic Acid	111-121	glutamic--pyruvic transaminase	Homo sapiens	22-46
28394261-0	2017	Folate cycle enzyme MTHFD1L confers metabolic advantages in hepatocellular carcinoma.	Folic Acid	0-6	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like	Homo sapiens	20-27
28394261-5	2017	We found that an enzyme in the folate cycle, methylenetetrahydrofolate dehydrogenase 1-like (MTHFD1L), plays an essential role in support of cancer growth.	Folic Acid	31-37	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like	Homo sapiens	45-91
28394261-5	2017	We found that an enzyme in the folate cycle, methylenetetrahydrofolate dehydrogenase 1-like (MTHFD1L), plays an essential role in support of cancer growth.	Folic Acid	31-37	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like	Homo sapiens	93-100
28394261-9	2017	Taken together, our study identifies MTHFD1L in the folate cycle as an important metabolic pathway in cancer cells with the potential for therapeutic targeting.	Folic Acid	52-58	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like	Homo sapiens	37-44
28457141-4	2017	Here we imitate this toxin-based delivery strategy in an artificial setting, by bioreversible conjugation of a cytotoxic cargo protein (RNase A) with receptor-targeting PEG-folate and the pH-specific endosomolytic peptide INF7 as synthetic delivery domains.	Folic Acid	173-179	ribonuclease A family member 1, pancreatic	Homo sapiens	136-143
28469775-0	2017	Melatonin promoted renal regeneration in folic acid-induced acute kidney injury via inhibiting nucleocytoplasmic translocation of HMGB1 in tubular epithelial cells.	Folic Acid	41-51	high mobility group box 1	Homo sapiens	130-135
27799486-3	2017	We investigated the involvement of sphingosine kinase 1 and 2 (SphK1 and SphK2), which phosphorylate sphingosine to produce sphingosine 1-phosphate, in kidney fibrosis induced by folic acid (FA) or unilateral ischemia-reperfusion injury.	Folic Acid	179-189	sphingosine kinase 1	Mus musculus	35-61
27799486-3	2017	We investigated the involvement of sphingosine kinase 1 and 2 (SphK1 and SphK2), which phosphorylate sphingosine to produce sphingosine 1-phosphate, in kidney fibrosis induced by folic acid (FA) or unilateral ischemia-reperfusion injury.	Folic Acid	179-189	sphingosine kinase 1	Mus musculus	63-68
27799486-3	2017	We investigated the involvement of sphingosine kinase 1 and 2 (SphK1 and SphK2), which phosphorylate sphingosine to produce sphingosine 1-phosphate, in kidney fibrosis induced by folic acid (FA) or unilateral ischemia-reperfusion injury.	Folic Acid	179-189	sphingosine kinase 2	Mus musculus	73-78
28228507-8	2017	Under folate deficiency, ALDH2 knockdown cells exhibited a 37% lower ratio of [14C]-formate to [3H]-hypoxanthine (P &lt; 0.001) compared with wild-type HepG2 cells, indicating decreased use of exogenous formate, or increased endogenous formate synthesis, for de novo purine biosynthesis.Conclusions: In HepG2 cells, ADH5 is a source of formate for de novo purine biosynthesis, especially during folate deficiency when folate-dependent formate production is limited.	Folic Acid	6-12	aldehyde dehydrogenase 2 family member	Homo sapiens	25-30
28228507-8	2017	Under folate deficiency, ALDH2 knockdown cells exhibited a 37% lower ratio of [14C]-formate to [3H]-hypoxanthine (P &lt; 0.001) compared with wild-type HepG2 cells, indicating decreased use of exogenous formate, or increased endogenous formate synthesis, for de novo purine biosynthesis.Conclusions: In HepG2 cells, ADH5 is a source of formate for de novo purine biosynthesis, especially during folate deficiency when folate-dependent formate production is limited.	Folic Acid	395-401	aldehyde dehydrogenase 2 family member	Homo sapiens	25-30
28228507-8	2017	Under folate deficiency, ALDH2 knockdown cells exhibited a 37% lower ratio of [14C]-formate to [3H]-hypoxanthine (P &lt; 0.001) compared with wild-type HepG2 cells, indicating decreased use of exogenous formate, or increased endogenous formate synthesis, for de novo purine biosynthesis.Conclusions: In HepG2 cells, ADH5 is a source of formate for de novo purine biosynthesis, especially during folate deficiency when folate-dependent formate production is limited.	Folic Acid	395-401	aldehyde dehydrogenase 2 family member	Homo sapiens	25-30
28723213-1	2017	A dual functional fluorescent core-shell Ag2S@Carbon nanostructure is prepared by a hydrothermally assisted multi-amino synthesis approach with folic acid (FA), polyethylenimine (PEI), and mannoses (Mans) as carbon and nitrogen sources (FA-PEI-Mans-Ag2S nanocomposite shortly as Ag2S@C).	Folic Acid	144-154	angiotensin II receptor type 1	Homo sapiens	41-45
27597531-1	2017	The common R653Q variant (~20% homozygosity in Caucasians) in the synthetase domain of the folate-metabolizing enzyme MTHFD1 reduces purine synthesis.	Folic Acid	91-97	methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase	Mus musculus	118-124
28056489-2	2017	METHOD: Using HFUS, we imaged embryos carrying loss of function alleles of Gldc encoding glycine decarboxylase, a component of the glycine cleavage system in mitochondrial folate metabolism, which is known to be associated with cranial NTDs and NKH in humans.	Folic Acid	172-178	glycine decarboxylase	Homo sapiens	75-79
28056489-2	2017	METHOD: Using HFUS, we imaged embryos carrying loss of function alleles of Gldc encoding glycine decarboxylase, a component of the glycine cleavage system in mitochondrial folate metabolism, which is known to be associated with cranial NTDs and NKH in humans.	Folic Acid	172-178	glycine decarboxylase	Homo sapiens	89-110
28151610-3	2017	We included studies that focused on the use of folic acid supplementation (by itself or in multivitamin or prenatal supplement form) for the prevention of NTD-affected pregnancies in women of childbearing age.	Folic Acid	47-57	fuzzy planar cell polarity protein	Homo sapiens	155-158
28733112-2	2017	Limited knowledge exists on the impact of folate status or obesity on DNA methylation of genes related to NTD risk and folate metabolism.	Folic Acid	42-48	fuzzy planar cell polarity protein	Homo sapiens	106-109
28733112-11	2017	Increased NTD risk and abnormal folate metabolism in obesity may be due to a distinctive epigenetic response to folate status in these genes.	Folic Acid	112-118	fuzzy planar cell polarity protein	Homo sapiens	10-13
27686582-7	2016	Folate incorporation increased the frequency of intracellular PCCA detection 45-fold for MDA-MB-231 cells and 7-fold for MCF-7 cells, relative to untargeted PCCAs.	Folic Acid	0-6	propionyl-CoA carboxylase subunit alpha	Homo sapiens	62-66
27613143-2	2016	Various important drugs transported by ABCC4 include antiviral and anticancer drugs as well as endogenous molecules such as bile acids, cyclic nucleotides, folates, prostaglandins and steroids.	Folic Acid	156-163	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	Mus musculus	39-44
27733392-4	2016	OBJECTIVE: We determined the association of the TCN2 776C G polymorphism and folate intake with peripheral neuropathy in elders with normal plasma concentrations of vitamin B-12.	Folic Acid	77-83	transcobalamin 2	Homo sapiens	48-52
27733392-10	2016	CONCLUSION: The TCN2 776C G polymorphism is associated with increased odds of peripheral neuropathy in the elderly, even with a normal vitamin B-12 status, especially if their folate intake is &gt;2 times the Recommended Dietary Allowance.	Folic Acid	176-182	transcobalamin 2	Homo sapiens	16-20
27852928-6	2016	By means of this method, we identified a motif in human precursor microRNA 125a (hsa-pre-miR-125a) that interacts with folic acid.	Folic Acid	119-129	microRNA 125a	Homo sapiens	89-97
27992360-11	2016	Finally, homocysteine inhibited DNA methyltransferase-1 activity and promoted CD40 intermediate monocyte differentiation, which was reversed by folic acid in peripheral blood monocyte.	Folic Acid	144-154	CD40 molecule	Homo sapiens	78-82
27604992-10	2016	In women with low folate intake specifically, increased risks were observed for CBS rs2851391 (OR = 3.6, 95%CI = 1.3-9.6) and the R259P nonsynonymous variant of TCN2 (rs1801198; OR = 2.8, 95%CI = 1.2-6.3).	Folic Acid	18-24	transcobalamin 2	Homo sapiens	161-165
27707701-2	2016	Common polymorphisms in folate genes, such as methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase (MTHFD1) R653Q, may modulate the effects of elevated folic acid intake.	Folic Acid	213-223	methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase	Mus musculus	161-167
27389146-4	2016	Relative to untreated controls, folate-targeted nanoparticles significantly reduced the levels of RelA mRNA in VCaP and LNCaP cells by 44% and 22% respectively (P&lt;0.001).	Folic Acid	32-38	RELA proto-oncogene, NF-kB subunit	Homo sapiens	98-102
27735840-9	2016	CONCLUSION: During pregnancy, the BHMT pathway is affected by folate status and by the variant BHMT c.716A allele.	Folic Acid	62-68	betaine--homocysteine S-methyltransferase	Homo sapiens	34-38
27302066-1	2016	Our previous study suggested that ceramide synthase 6 (CerS6), an enzyme in sphingolipid biosynthesis, is regulated by p53: CerS6 was elevated in several cell lines in response to transient expression of p53 or in response to folate stress, which is known to activate p53.	Folic Acid	226-232	ceramide synthase 6	Homo sapiens	55-60
27302066-1	2016	Our previous study suggested that ceramide synthase 6 (CerS6), an enzyme in sphingolipid biosynthesis, is regulated by p53: CerS6 was elevated in several cell lines in response to transient expression of p53 or in response to folate stress, which is known to activate p53.	Folic Acid	226-232	ceramide synthase 6	Homo sapiens	124-129
27392858-5	2016	Low PSEN1 methylation was linked to low folate levels as well as to low promoter methylation of BACE1 and DNMTs genes.	Folic Acid	40-46	presenilin 1	Homo sapiens	4-9
26906511-0	2016	Folic Acid Attenuates Vascular Endothelial Cell Injury Caused by Hypoxia via the Inhibition of ERK1/2/NOX4/ROS Pathway.	Folic Acid	0-10	NADPH oxidase 4	Homo sapiens	102-106
26906511-9	2016	In addition, folic acid decreased protein expressions of NOX4 and p-ERK1/2, while it increased the protein expression of eNOS in HUVECs.	Folic Acid	13-23	NADPH oxidase 4	Homo sapiens	57-61
26000371-0	2014	Anti-tumor immune response of folate-conjugated chitosan nanoparticles containing the IP-10 gene in mice with hepatocellular carcinoma.	Folic Acid	30-36	chemokine (C-X-C motif) ligand 10	Mus musculus	86-91
26000371-2	2014	In this study, folate-conjugated chitosan nanoparticles (FA-CS-NPs) were loaded with mouse interferon-gamma-inducible protein-10 (IP-10) plasmid, which were used for immunotherapy in HCC.	Folic Acid	15-21	chemokine (C-X-C motif) ligand 10	Mus musculus	91-128
27213354-3	2016	SLC19A1, also referred to as reduced folate carrier 1 (RFC1), is a member of the solute carrier group of transporters and is one of the key enzymes in the folate metabolism pathway.	Folic Acid	37-43	solute carrier family 19 member 1	Homo sapiens	0-7
26000371-2	2014	In this study, folate-conjugated chitosan nanoparticles (FA-CS-NPs) were loaded with mouse interferon-gamma-inducible protein-10 (IP-10) plasmid, which were used for immunotherapy in HCC.	Folic Acid	15-21	chemokine (C-X-C motif) ligand 10	Mus musculus	130-135
26000371-10	2014	These data suggested that the gene delivery system of folate-conjugated chitosan nanoparticle loaded with IP-10 plasmid may be a promising strategy for immunotherapy of HCC.	Folic Acid	54-60	chemokine (C-X-C motif) ligand 10	Mus musculus	106-111
26959650-2	2016	Reduced folate carrier 1, encoded by the SLC19A1 gene, is a transporter of folate.	Folic Acid	8-14	solute carrier family 19 member 1	Homo sapiens	41-48
25213861-6	2014	During folate deficiency mouse liver MTHFD1 levels are enriched in the nucleus &gt;2-fold at the expense of levels in the cytosol.	Folic Acid	7-13	methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase	Mus musculus	37-43
27339384-3	2016	The renal cell expression of TWEAK and Fn14 is increased in human and experimental AKI and targeting TWEAK or Fn14 by genetic means or neutralizing antibodies was protective in kidney injury induced by folic acid overdose, ischemia-reperfusion, or unilateral ureteral obstruction.	Folic Acid	202-212	TNF receptor superfamily member 12A	Homo sapiens	39-43
27339384-3	2016	The renal cell expression of TWEAK and Fn14 is increased in human and experimental AKI and targeting TWEAK or Fn14 by genetic means or neutralizing antibodies was protective in kidney injury induced by folic acid overdose, ischemia-reperfusion, or unilateral ureteral obstruction.	Folic Acid	202-212	TNF receptor superfamily member 12A	Homo sapiens	110-114
25213861-8	2014	The enrichment of folate cofactors and MTHFD1 protein in the nucleus during folate deficiency in mouse liver and human cell lines accounts for previous metabolic studies that indicated 5,10-methylenetetrahydrofolate is preferentially directed toward de novo thymidylate biosynthesis at the expense of homocysteine remethylation during folate deficiency.	Folic Acid	76-82	methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase	Mus musculus	39-45
25213861-8	2014	The enrichment of folate cofactors and MTHFD1 protein in the nucleus during folate deficiency in mouse liver and human cell lines accounts for previous metabolic studies that indicated 5,10-methylenetetrahydrofolate is preferentially directed toward de novo thymidylate biosynthesis at the expense of homocysteine remethylation during folate deficiency.	Folic Acid	76-82	methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase	Mus musculus	39-45
26283674-6	2016	Knockin rpS6(p-/-) mice, in which rpS6 cannot be phosphorylated because of substitution of all five phosphorylatable serines with alanines, had impaired PTH secretion after experimental uremia- or folic acid-induced AKI.	Folic Acid	197-207	ribosomal protein S6	Mus musculus	8-12
25184762-3	2014	The successful immobilization of folic acid was investigated both quantitatively (TGA, EA, XPS) and qualitatively (AT-IR, UV-vis, zeta-potential).	Folic Acid	33-43	T-box transcription factor 1	Homo sapiens	82-85
26879376-3	2016	Here, we describe in vivo and in vitro delivery system for Survivin siRNA (siSurvivin) assembled with passive LDH with a particle size of 100 nm or active LDH conjugated with a cancer overexpressing receptor targeting ligand, folic acid (LDHFA), conferring them an ability to target the tumor by either EPR-based clathrin-mediated or folate receptor-mediated endocytosis.	Folic Acid	226-236	baculoviral IAP repeat-containing 5	Mus musculus	59-67
25293959-2	2014	Low maternal folate is the strongest known contributing factor, making variants in genes in the folate metabolic pathway attractive candidates for NTD risk.	Folic Acid	13-19	fuzzy planar cell polarity protein	Homo sapiens	147-150
25869180-9	2016	In women, rs10817542 (ZNF618) and rs719856 (CD2AP) had an interaction with beta-carotene and folate intake and rs5443 (GNB3) had an interaction with vitamin E intake on baPWV.	Folic Acid	93-99	CD2 associated protein	Homo sapiens	44-49
26471523-5	2016	We confirmed by overexpression that FOL2 was the key gene encoding the rate-limiting step of folate biosynthesis in wine yeast.	Folic Acid	93-99	GTP cyclohydrolase I	Saccharomyces cerevisiae S288C	36-40
26471523-6	2016	In this study, we also show that overexpression of other folate biosynthesis genes, including ABZ1, ABZ2, DFR1, FOL1 and FOL3, had no effect on folate levels in wine.	Folic Acid	57-63	4-amino-4-deoxychorismate synthase	Saccharomyces cerevisiae S288C	94-98
26804918-5	2016	These data implicate the PGC-1alpha/ERRalpha axis as a core regulatory node of folate cycle metabolism and further suggest that activators of AMPK could be used to modulate this pathway in cancer.	Folic Acid	79-85	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	142-146
26646753-4	2016	Furthermore, the mCA is functionalized with folic acid to improve the target specificity.	Folic Acid	44-54	radial spoke head 1 homolog (Chlamydomonas)	Mus musculus	17-20
26783755-7	2016	Furthermore, the siRNA silencing of CerS6 robustly protected A549 lung adenocarcinoma cells from MTX toxicity, while the silencing of another ceramide synthase, CerS4, which was also responsive to folate stress in our previous study, did not interfere with the MTX effect.	Folic Acid	197-203	ceramide synthase 6	Homo sapiens	36-41
26481949-7	2016	After the additional adjustment for energy intake, whole nut consumers had higher intakes of dietary fibre, vitamin E, folate, Cu, Mg, K, P and Zn (all P&lt;=0 044), whereas cholesterol and vitamin B12 intakes were significantly lower (both P&lt;=0 013).	Folic Acid	119-125	NUT midline carcinoma family member 1	Homo sapiens	57-60
25724324-0	2016	The Phosphorylation State of GSK3beta Serine 9 Correlated to the Development of Valproic Acid-Associated Fetal Cardiac Teratogenicity, Fetal VPA Syndrome, Rescued by Folic Acid Administration.	Folic Acid	166-176	glycogen synthase kinase 3 beta, genome duplicate a	Danio rerio	29-37
25724324-11	2016	Folic acid rescued the GSK3beta Ser 9 phosphorylation and reversed the valproic acid-induced cardiac morphological, functional, and biochemical defects.	Folic Acid	0-10	glycogen synthase kinase 3 beta, genome duplicate a	Danio rerio	23-31
27738387-8	2016	Finally, p-IkappaBalpha, which indirectly reflects NF-kappaB complex activation, and JNK phosphorylation resulted dose-dependently downregulated by folic acid pretreatment of LPS-activated cells, whereas p38 MAPK phosphorylation resulted significantly upregulated by folic acid treatment.	Folic Acid	148-158	mitogen-activated protein kinase 14	Mus musculus	204-207
25973643-7	2016	Moreover, folic acid in combination with vitamin B12 also attenuated the nicotine-induced changes in markers of oxidative stress (17-88% recovery), TNF-alpha (40-99% recovery), and IL-6 level (47-65% recovery), CRP level (59-73% recovery), expression of NF-kappaB and caspase-3, and apoptosis in pancreatic islet cells.	Folic Acid	10-20	caspase 3	Rattus norvegicus	268-277
26408344-1	2015	BACKGROUND: A single nucleotide polymorphism (SNP) in the synthetase domain of the trifunctional folate-dependent enzyme MTHFD1 (c.1958G&gt;A, R653Q) has been linked to adverse pregnancy outcomes, neural tube defects, and possibly congenital heart defects.	Folic Acid	97-103	methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase	Mus musculus	121-127
25855779-8	2015	Ddah1(PT-/-) mice were protected from reduced kidney tissue mass, collagen deposition, and profibrotic cytokine expression in two independent renal injury models: folate nephropathy and unilateral ureteric obstruction.	Folic Acid	163-169	dimethylarginine dimethylaminohydrolase 1	Mus musculus	0-5
26350415-9	2015	These findings suggest that PGA capsule induces NO production in macrophages by triggering both TLR2 and PAFR signaling pathways which lead to activation of NF-kB and STAT-1, respectively.	Folic Acid	28-31	toll-like receptor 2	Mus musculus	96-100
26400185-0	2015	Folic acid supplementation during high-fat diet feeding restores AMPK activation via an AMP-LKB1-dependent mechanism.	Folic Acid	0-10	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	65-69
26400185-4	2015	The aim of the present study was to investigate the effect of folic acid on hepatic AMPK during high-fat diet feeding and the mechanisms involved.	Folic Acid	62-72	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	84-88
26400185-7	2015	Folic acid supplementation restored AMPK phosphorylation (activation) and reduced blood glucose and hepatic cholesterol levels.	Folic Acid	0-10	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	36-40
26400185-8	2015	Activation of AMPK by folic acid was mediated through an elevation of its allosteric activator AMP and activation of its upstream kinase, namely, liver kinase B1 (LKB1) in the liver.	Folic Acid	22-32	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	14-18
26195551-7	2015	PGA stimulated Toll-like receptor 2 (TLR2) but not TLR4 in Chinese hamster ovary cells expressing either TLR2 or TLR4.	Folic Acid	0-3	toll-like receptor 4	Cricetulus griseus	113-117
26195551-8	2015	The ability of PGA to induce TNF-alpha and IL-6 was retained in TLR4(-/-) but not TLR2(-/-) BMDMs.	Folic Acid	15-18	toll-like receptor 4	Cricetulus griseus	64-68
26043696-8	2015	VCP is unable to unfold Ub5-DHFR in a tight structure when it binds with methotrexate, a folate analog with high affinity to DHFR.	Folic Acid	89-95	valosin containing protein	Homo sapiens	0-3
25375039-5	2015	Using flow cytometry, we identified the cells responsible for uptake of cyanine 5-conjugated folate as FRbeta(+) interstitial macrophages and pulmonary monocytes, which coexpressed markers associated with an M1 proinflammatory macrophage phenotype.	Folic Acid	93-99	folate receptor 2 (fetal)	Mus musculus	103-109
25860940-5	2015	This study adds upregulation of folate-mediated one-carbon metabolism to the known consequences of MYCN amplification, and suggests that this pathway might be targeted in poor outcome tumors with MYCN amplification and high SLC19A1 expression.	Folic Acid	32-38	solute carrier family 19 member 1	Homo sapiens	224-231
25846410-5	2015	In addition, multiple SNPs in betaine-homocysteine methyltransferase (BHMT and BHMT2) were also identified to be associated with the occurrence of OHDs through significant main infant genetic effects and interaction effects with maternal use of folic acid supplements.	Folic Acid	245-255	betaine--homocysteine S-methyltransferase	Homo sapiens	70-74
25590678-4	2015	Beginning in 1998, the United States mandated fortification of enriched cereal grain products with 140 microg of folic acid per 100 g. Immediately after mandatory fortification, the birth prevalence of NTD cases declined.	Folic Acid	113-123	fuzzy planar cell polarity protein	Homo sapiens	202-205
25590679-7	2015	The recommendation that women should take folic acid supplements just before and during early pregnancy is not being followed by many women and offers an opportunity for NTD prevention, especially among women who are at a higher risk because they have had a previous pregnancy affected by an NTD.	Folic Acid	42-52	fuzzy planar cell polarity protein	Homo sapiens	170-173
25590679-7	2015	The recommendation that women should take folic acid supplements just before and during early pregnancy is not being followed by many women and offers an opportunity for NTD prevention, especially among women who are at a higher risk because they have had a previous pregnancy affected by an NTD.	Folic Acid	42-52	fuzzy planar cell polarity protein	Homo sapiens	292-295
26929921-3	2015	This study aimed to evaluate the effect of high dose folic acid (FA) on serum Hcy and Lp(a) concentrations with respect to methylenetetrahydrofolate reductase (MTHFR) polymorphisms 677C T during pregnancy.	Folic Acid	53-63	lipoprotein(a)	Homo sapiens	86-91
25757918-3	2015	Recently, we have developed folate-conjugated methyl-beta-cyclodextrin (FA-M-beta-CyD) and clarified its potential as a new antitumor agent involved in autophagic cell death.	Folic Acid	28-34	cytochrome b-245, beta polypeptide	Mus musculus	82-85
26879384-13	2016	To further reduce NTD risk in the population, fortification staples with folic acid should be considered.	Folic Acid	73-83	fuzzy planar cell polarity protein	Homo sapiens	18-21
27022421-0	2016	Folate-modified Chitosan Nanoparticles Containing the IP-10 Gene Enhance Melanoma-specific Cytotoxic CD8(+)CD28(+) T Lymphocyte Responses.	Folic Acid	0-6	chemokine (C-X-C motif) ligand 10	Mus musculus	54-59
27022421-3	2016	This study aimed to investigate the anti-tumor response of a combination therapy employing folate-modified chitosan nanoparticles containing IP-10 (interferon-gamma-inducible protein-10) plus melanoma TRP2-specific CD8(+)CD28(+) T cells.	Folic Acid	91-97	chemokine (C-X-C motif) ligand 10	Mus musculus	141-146
27022421-3	2016	This study aimed to investigate the anti-tumor response of a combination therapy employing folate-modified chitosan nanoparticles containing IP-10 (interferon-gamma-inducible protein-10) plus melanoma TRP2-specific CD8(+)CD28(+) T cells.	Folic Acid	91-97	chemokine (C-X-C motif) ligand 10	Mus musculus	148-185
27022421-4	2016	METHODS: We prepared folate-modified chitosan nanoparticles containing the mouse IP-10 gene (FA-CS-mIP-10), and induced melanoma TRP2-specific CD8(+)CD28(+) T cells by co-culturing them with artificial antigen-presenting cells.	Folic Acid	21-27	chemokine (C-X-C motif) ligand 10	Mus musculus	81-86
26938218-9	2016	Glycine and CPS1 are connected through the one-carbon pool by the folate pathway and the urea cycle.	Folic Acid	66-72	carbamoyl-phosphate synthase 1	Homo sapiens	12-16
26311115-4	2016	Folic acid-induced acute kidney injury increased calvaria FGF23 mRNA and serum FGF23 and parathyroid hormone (PTH) levels at 6 h. The FGFR1 receptor inhibitor PD173074 prevented the folic acid-induced increase in both FGF23 mRNA and serum levels but had no effect on serum PTH levels.	Folic Acid	0-10	fibroblast growth factor 23	Rattus norvegicus	58-63
26311115-4	2016	Folic acid-induced acute kidney injury increased calvaria FGF23 mRNA and serum FGF23 and parathyroid hormone (PTH) levels at 6 h. The FGFR1 receptor inhibitor PD173074 prevented the folic acid-induced increase in both FGF23 mRNA and serum levels but had no effect on serum PTH levels.	Folic Acid	0-10	fibroblast growth factor 23	Rattus norvegicus	79-84
26311115-4	2016	Folic acid-induced acute kidney injury increased calvaria FGF23 mRNA and serum FGF23 and parathyroid hormone (PTH) levels at 6 h. The FGFR1 receptor inhibitor PD173074 prevented the folic acid-induced increase in both FGF23 mRNA and serum levels but had no effect on serum PTH levels.	Folic Acid	0-10	fibroblast growth factor 23	Rattus norvegicus	79-84
26272218-9	2016	A recent population-based US study estimated that the reduction in NTD rates by folic acid is more modest than previously predicted.	Folic Acid	80-90	fuzzy planar cell polarity protein	Homo sapiens	67-70
26272218-10	2016	The potential of NTD prevention by folic acid is underutilized due to low adherence with folic acid supplementation, and calls for revising the policy of supplementation have been raised.	Folic Acid	35-45	fuzzy planar cell polarity protein	Homo sapiens	17-20
26272218-10	2016	The potential of NTD prevention by folic acid is underutilized due to low adherence with folic acid supplementation, and calls for revising the policy of supplementation have been raised.	Folic Acid	89-99	fuzzy planar cell polarity protein	Homo sapiens	17-20
26582802-5	2016	PKM2 has lower catalytic activity resulting in decreased glycolytic flux and the accumulation of upstream intermediates that were redirected to the pentose phosphate pathway and serine/folate biosynthesis, 2 important NADPH producing pathways stemming from glycolysis.	Folic Acid	185-191	pyruvate kinase, muscle	Mus musculus	0-4
26821380-11	2016	Given the tolerability of glycine and folate in humans, this study points to a potential novel treatment for SLC25A38 congenital sideroblastic anemia.	Folic Acid	38-44	solute carrier family 25 member 38	Homo sapiens	109-117
26520043-0	2016	Tailored-CuO-nanowire decorated with folic acid mediated coupling of the mitochondrial-ROS generation and miR425-PTEN axis in furnishing potent anti-cancer activity in human triple negative breast carcinoma cells.	Folic Acid	37-47	microRNA 425	Homo sapiens	106-112
26108864-2	2015	Increased maternal intake of folic acid (FA) during the periconceptional period is known to reduce NTD risk.	Folic Acid	29-39	fuzzy planar cell polarity protein	Homo sapiens	99-102
26403086-1	2015	Myricetin is a flavonoid that has recently been suggested to induce sustained inhibition of proton-coupled folate transporter (PCFT/SLC46A1), which operates for intestinal folate uptake.	Folic Acid	107-113	solute carrier family 46 member 1	Canis lupus familiaris	132-139
26376452-8	2015	As regards risk of BC subtypes, high riboflavin and folate were significantly associated with lower risk of estrogen receptor positive (ER+) and progesterone receptor positive (PR+) cancers, and high thiamine was associated with lower risk of ER-PR- cancers.	Folic Acid	52-58	progesterone receptor	Homo sapiens	145-166
25105440-2	2015	The genes MTHFR, MTR, MTRR, and TCN2 play key roles in folate metabolism.	Folic Acid	55-61	transcobalamin 2	Homo sapiens	32-36
26021967-14	2015	The transcriptional analyses supported the participation of COMT in the folate pathway, which partakes in the complex network of genexgene and genexenvironment interactions of MDD etiopathogenesis.	Folic Acid	72-78	catechol-O-methyltransferase	Homo sapiens	60-64
25728980-6	2015	The pooled analysis also revealed that NTD-affected mothers had significantly lower levels of folate (RoM: 0.93, 95% CI: 0.88-0.97, P = 0.002), vitamin B12 (RoM: 0.91, 95% CI: 0.87-0.95, P = 3.6 x 10(-5)) and red blood cell folate (RoM: 0.92, 95% CI: 0.86-0.98, P = 0.01).	Folic Acid	94-100	fuzzy planar cell polarity protein	Homo sapiens	39-42
25728980-6	2015	The pooled analysis also revealed that NTD-affected mothers had significantly lower levels of folate (RoM: 0.93, 95% CI: 0.88-0.97, P = 0.002), vitamin B12 (RoM: 0.91, 95% CI: 0.87-0.95, P = 3.6 x 10(-5)) and red blood cell folate (RoM: 0.92, 95% CI: 0.86-0.98, P = 0.01).	Folic Acid	224-230	fuzzy planar cell polarity protein	Homo sapiens	39-42
25595473-0	2015	Folate-bovine serum albumin functionalized polymeric micelles loaded with superparamagnetic iron oxide nanoparticles for tumor targeting and magnetic resonance imaging.	Folic Acid	0-6	albumin	Mus musculus	14-27
25595473-1	2015	Polymeric micelles functionalized with folate conjugated bovine serum albumin (FA-BSA) and loaded with superparamagnetic iron oxide nanoparticles (SPIONs) are investigated as a specific contrast agent for tumor targeting and magnetic resonance imaging (MRI) in vitro and in vivo.	Folic Acid	39-45	albumin	Mus musculus	64-77
26045811-8	2015	In human extravillous trophoblast HTR8/SVneo, folate ameliorated the Dex-induced supress of cell migration and improved the expression/activity of MMP2 and MMP9.	Folic Acid	46-52	matrix metallopeptidase 2	Homo sapiens	147-151
26646725-10	2015	The top folate-sensitive genes defined by their associated CpG sites were enriched for numerous transcription factors by Gene Set Enrichment Analysis, including those implicated in cancer development (e.g., MYC-associated zinc finger protein).	Folic Acid	8-14	MYC associated zinc finger protein	Homo sapiens	207-241
26789836-7	2015	Very high levels of maternal folate were significantly associated with increased H3/H4 acetylation at GATA3 and/or IL9 promoter regions in CD4+ T cells in CB.	Folic Acid	29-35	interleukin 9	Homo sapiens	115-118
26780389-1	2015	Maternal folate status before and during pregnancy influences a woman"s risk of having a pregnancy affected by congenital malformations of the neural tube (neural tube defects, NTD).	Folic Acid	9-15	fuzzy planar cell polarity protein	Homo sapiens	177-180
26780389-2	2015	For NTD prevention, it is recommended that women use periconceptional supplementation of folic acid.	Folic Acid	89-99	fuzzy planar cell polarity protein	Homo sapiens	4-7
26780389-4	2015	Insufficient data exists on the relation between folate status and the risk of NTD.	Folic Acid	49-55	fuzzy planar cell polarity protein	Homo sapiens	79-82
26780389-5	2015	A recent study published in the British Medical Journal provides evidence for a generalizable dose-response relation between folate status and risk of NTD.	Folic Acid	125-131	fuzzy planar cell polarity protein	Homo sapiens	151-154
26780389-6	2015	The lowest risk of having a child with NTD was related to red blood cell (RBC) folate concentrations of &gt;= 1000 nmol/L.	Folic Acid	79-85	fuzzy planar cell polarity protein	Homo sapiens	39-42
25261501-10	2014	Tg6-IgA/IgG was detected in 7 of 68 patients (cerebellar ataxia, 3; myelopathy, 2; ataxia and parkinsonism, 1; neuropathy, 1); the 2 patients with myelopathy had neurologic disorders explained by malabsorption of copper, vitamin E, and folate rather than by neurologic autoimmunity.	Folic Acid	236-242	transglutaminase 6	Homo sapiens	0-3
25202269-6	2014	Dietary folate deficiency significantly decreased LCMT1, methylated PP2A and PP2A/Balpha levels in all brain regions examined from aged Mthfr (+/+) mice, and further exacerbated the regional effects of MTHFR deficiency in aged Mthfr (+/-) mice.	Folic Acid	8-14	leucine carboxyl methyltransferase 1	Mus musculus	50-55
25285163-3	2014	To overcome these barriers, we developed a folate receptor targeted co-delivery system folate-doxorubicin/Bmi1 siRNA liposome (FA-DOX/siRNA-L).	Folic Acid	43-49	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	106-110
24949876-1	2014	The RFC (reduced folate carrier) is the principal mechanism by which folates and clinically used antifolates are delivered to mammalian cells.	Folic Acid	69-76	solute carrier family 19 member 1	Homo sapiens	4-7
24949876-1	2014	The RFC (reduced folate carrier) is the principal mechanism by which folates and clinically used antifolates are delivered to mammalian cells.	Folic Acid	69-76	solute carrier family 19 member 1	Homo sapiens	9-31
24949876-9	2014	Our results demonstrate a novel post-transcriptional regulation of hRFC involving: (i) increased hRFC transcripts and proteins, accompanying increased extracellular folates, attributable to differences in hRFC transcript stabilities; and (ii) increased retention of hRFC in the ER under conditions of folate excess, because of impaired intracellular trafficking and plasma membrane targeting.	Folic Acid	165-172	solute carrier family 19 member 1	Homo sapiens	67-71
25115437-4	2014	Because maternal folic acid supplementation reduces human NTD risk in some populations by 60 to 70%, it is likely that NTD predisposition is often associated with a defect in folate-dependent one-carbon metabolism.	Folic Acid	17-27	fuzzy planar cell polarity protein	Homo sapiens	58-61
25115437-4	2014	Because maternal folic acid supplementation reduces human NTD risk in some populations by 60 to 70%, it is likely that NTD predisposition is often associated with a defect in folate-dependent one-carbon metabolism.	Folic Acid	175-181	fuzzy planar cell polarity protein	Homo sapiens	119-122
24237708-2	2014	The reduced folate carrier gene (RFC) encodes reduced folate carrier, a protein that transports into the cell both folate and methotrexate, a commonly used chemotherapeutic drug, has been proved polymorphic at position 80 (G A).	Folic Acid	12-18	solute carrier family 19 member 1	Homo sapiens	33-36
24237708-2	2014	The reduced folate carrier gene (RFC) encodes reduced folate carrier, a protein that transports into the cell both folate and methotrexate, a commonly used chemotherapeutic drug, has been proved polymorphic at position 80 (G A).	Folic Acid	54-60	solute carrier family 19 member 1	Homo sapiens	4-31
24237708-2	2014	The reduced folate carrier gene (RFC) encodes reduced folate carrier, a protein that transports into the cell both folate and methotrexate, a commonly used chemotherapeutic drug, has been proved polymorphic at position 80 (G A).	Folic Acid	54-60	solute carrier family 19 member 1	Homo sapiens	33-36
24771227-3	2014	The aim of this study was to investigate whether the genetic polymorphisms MTHFR C677T and A1298C, MTR A2756G, TYMS 2R/3R and SLC19A1 G80A, involved in folate metabolism, increase the risk of neuroblastoma in Brazilian children.	Folic Acid	152-158	solute carrier family 19 member 1	Homo sapiens	126-133
24771227-8	2014	Our results suggest that individuals carriers of genotype AA for the SLC19A1 gene present risk for the development of neuroblastoma and possibly have difficulty in absorption of folic acid by the cells, and this may adversely affect the metabolism of folate causing genomic instability and promoting the development of cancer.	Folic Acid	178-188	solute carrier family 19 member 1	Homo sapiens	69-76
24771227-8	2014	Our results suggest that individuals carriers of genotype AA for the SLC19A1 gene present risk for the development of neuroblastoma and possibly have difficulty in absorption of folic acid by the cells, and this may adversely affect the metabolism of folate causing genomic instability and promoting the development of cancer.	Folic Acid	251-257	solute carrier family 19 member 1	Homo sapiens	69-76
25026938-0	2014	Folic acid conjugated cross-linked acrylic polymer (FA-CLAP) hydrogel for site specific delivery of hydrophobic drugs to cancer cells.	Folic Acid	0-10	BCL10 immune signaling adaptor	Homo sapiens	55-59
25026938-4	2014	For that, we have synthesized a folic acid conjugated PEG cross-linked acrylic polymer (FA-CLAP) hydrogel and investigated its loading and release of curcumin.	Folic Acid	32-42	BCL10 immune signaling adaptor	Homo sapiens	91-95
25026938-7	2014	Poly (ethyleneglycol) (PEG) diacrylate cross-linked acrylic polymer (PAA) was prepared via inverse emulsion polymerization technique and later conjugated it with folic acid (FA-CLAP).	Folic Acid	162-172	BCL10 immune signaling adaptor	Homo sapiens	177-181
25026938-13	2014	CONCLUSIONS: Results showed that curcumin entrapped folate conjugated cross-linked acrylic polymer (FA-CLAP) hydrogel showed higher cellular uptake than the non folate conjugated form.	Folic Acid	52-58	BCL10 immune signaling adaptor	Homo sapiens	103-107
24830618-1	2014	Glycinamide ribonucleotide transformylase (GART) is a folate-dependent enzyme in the de novo purine pathway that has been the target of antineoplastic intervention for almost 2 decades.	Folic Acid	54-60	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	Homo sapiens	0-41
24830618-1	2014	Glycinamide ribonucleotide transformylase (GART) is a folate-dependent enzyme in the de novo purine pathway that has been the target of antineoplastic intervention for almost 2 decades.	Folic Acid	54-60	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	Homo sapiens	43-47
25422218-6	2014	There were significant differences in HPV16 status (chi2=36.64, P&lt;0.001), CpG island methylation of FHIT (chi2=71.31, P&lt;0.001) and serum folate level (F=4.57, P=0.011) across the cervical histologic groups.	Folic Acid	143-149	fragile histidine triad diadenosine triphosphatase	Homo sapiens	103-107
25422218-7	2014	Interaction analysis showed that the ORs only with FHIT methylation (OR=11.47) or only with HPV 16 positive (OR=4.63) or with serum folate level lower than 3.19ng/ml (OR=1.68) in SCC group were all higher than the control status of HPV 16 negative and FHIT unmethylation and serum folate level more than 3.19ng/ml (OR=1).	Folic Acid	132-138	fragile histidine triad diadenosine triphosphatase	Homo sapiens	252-256
25422218-7	2014	Interaction analysis showed that the ORs only with FHIT methylation (OR=11.47) or only with HPV 16 positive (OR=4.63) or with serum folate level lower than 3.19ng/ml (OR=1.68) in SCC group were all higher than the control status of HPV 16 negative and FHIT unmethylation and serum folate level more than 3.19ng/ml (OR=1).	Folic Acid	281-287	fragile histidine triad diadenosine triphosphatase	Homo sapiens	51-55
24995314-3	2014	A common c.80G>A polymorphism (rs1051266) in the gene coding for the reduced folate carrier (SLC19A1 gene, commonly known as RFC-1 gene) was investigated as AD risk factor in Asian populations, yielding conflicting results.	Folic Acid	77-83	solute carrier family 19 member 1	Homo sapiens	93-100
24219311-1	2014	In a recent study, we attempted to confer a tumor-selective cytotoxic activity to methyl-beta-cyclodextrin (M-beta-CyD), we synthesized folate-conjugated M-beta-CyD (FA-M-beta-CyD), and demonstrated the potential of FA-M-beta-CyD as a novel anticancer agent at a high dose.	Folic Acid	136-142	cytochrome b-245, beta polypeptide	Mus musculus	115-118
24219311-1	2014	In a recent study, we attempted to confer a tumor-selective cytotoxic activity to methyl-beta-cyclodextrin (M-beta-CyD), we synthesized folate-conjugated M-beta-CyD (FA-M-beta-CyD), and demonstrated the potential of FA-M-beta-CyD as a novel anticancer agent at a high dose.	Folic Acid	136-142	cytochrome b-245, beta polypeptide	Mus musculus	161-164
24219311-1	2014	In a recent study, we attempted to confer a tumor-selective cytotoxic activity to methyl-beta-cyclodextrin (M-beta-CyD), we synthesized folate-conjugated M-beta-CyD (FA-M-beta-CyD), and demonstrated the potential of FA-M-beta-CyD as a novel anticancer agent at a high dose.	Folic Acid	136-142	cytochrome b-245, beta polypeptide	Mus musculus	161-164
24219311-1	2014	In a recent study, we attempted to confer a tumor-selective cytotoxic activity to methyl-beta-cyclodextrin (M-beta-CyD), we synthesized folate-conjugated M-beta-CyD (FA-M-beta-CyD), and demonstrated the potential of FA-M-beta-CyD as a novel anticancer agent at a high dose.	Folic Acid	136-142	cytochrome b-245, beta polypeptide	Mus musculus	161-164
25066213-4	2014	Thirteen variants in the pyrimidine metabolism genes, DPYD, DPYS, PPAT, and TYMS, also interacted significantly with folate in a multivariant analysis (corrected p = 9.9 x 10-6) but collectively explained only 0.2% of OC risk.	Folic Acid	117-123	phosphoribosyl pyrophosphate amidotransferase	Homo sapiens	66-70
25086046-0	2014	Rho GTPases RhoA and Rac1 mediate effects of dietary folate on metastatic potential of A549 cancer cells through the control of cofilin phosphorylation.	Folic Acid	53-59	ras homolog family member A	Mus musculus	12-16
25086046-0	2014	Rho GTPases RhoA and Rac1 mediate effects of dietary folate on metastatic potential of A549 cancer cells through the control of cofilin phosphorylation.	Folic Acid	53-59	Rac family small GTPase 1	Mus musculus	21-25
25086046-6	2014	We have further demonstrated that in A549 cells two GTPases, RhoA and Rac1, but not Cdc42, are immediate sensors of folate status: the siRNA silencing of RhoA or Rac1 blocked effects of folate on cofilin phosphorylation and cellular migration and invasion.	Folic Acid	116-122	ras homolog family member A	Mus musculus	61-65
25086046-6	2014	We have further demonstrated that in A549 cells two GTPases, RhoA and Rac1, but not Cdc42, are immediate sensors of folate status: the siRNA silencing of RhoA or Rac1 blocked effects of folate on cofilin phosphorylation and cellular migration and invasion.	Folic Acid	116-122	Rac family small GTPase 1	Mus musculus	70-74
25086046-6	2014	We have further demonstrated that in A549 cells two GTPases, RhoA and Rac1, but not Cdc42, are immediate sensors of folate status: the siRNA silencing of RhoA or Rac1 blocked effects of folate on cofilin phosphorylation and cellular migration and invasion.	Folic Acid	116-122	ras homolog family member A	Mus musculus	154-158
25086046-6	2014	We have further demonstrated that in A549 cells two GTPases, RhoA and Rac1, but not Cdc42, are immediate sensors of folate status: the siRNA silencing of RhoA or Rac1 blocked effects of folate on cofilin phosphorylation and cellular migration and invasion.	Folic Acid	116-122	Rac family small GTPase 1	Mus musculus	162-166
25086046-6	2014	We have further demonstrated that in A549 cells two GTPases, RhoA and Rac1, but not Cdc42, are immediate sensors of folate status: the siRNA silencing of RhoA or Rac1 blocked effects of folate on cofilin phosphorylation and cellular migration and invasion.	Folic Acid	186-192	ras homolog family member A	Mus musculus	61-65
25086046-6	2014	We have further demonstrated that in A549 cells two GTPases, RhoA and Rac1, but not Cdc42, are immediate sensors of folate status: the siRNA silencing of RhoA or Rac1 blocked effects of folate on cofilin phosphorylation and cellular migration and invasion.	Folic Acid	186-192	Rac family small GTPase 1	Mus musculus	70-74
25086046-6	2014	We have further demonstrated that in A549 cells two GTPases, RhoA and Rac1, but not Cdc42, are immediate sensors of folate status: the siRNA silencing of RhoA or Rac1 blocked effects of folate on cofilin phosphorylation and cellular migration and invasion.	Folic Acid	186-192	ras homolog family member A	Mus musculus	154-158
25086046-6	2014	We have further demonstrated that in A549 cells two GTPases, RhoA and Rac1, but not Cdc42, are immediate sensors of folate status: the siRNA silencing of RhoA or Rac1 blocked effects of folate on cofilin phosphorylation and cellular migration and invasion.	Folic Acid	186-192	Rac family small GTPase 1	Mus musculus	162-166
25264450-6	2014	RESULTS: Dietary folate intake was positively associated with HDL-C (p = 0.007), HDL-2 (p = 0.0011), HDL-3 (p = 0.0022), and apoA1 (p = 0.001).	Folic Acid	17-23	junctophilin 3	Homo sapiens	81-86
25264450-11	2014	CONCLUSIONS: This study is the first to report that dietary folate intake is associated with HDL-C, HDL-2, HDL-3, and apoA1 levels in humans.	Folic Acid	60-66	junctophilin 3	Homo sapiens	100-105
24949876-9	2014	Our results demonstrate a novel post-transcriptional regulation of hRFC involving: (i) increased hRFC transcripts and proteins, accompanying increased extracellular folates, attributable to differences in hRFC transcript stabilities; and (ii) increased retention of hRFC in the ER under conditions of folate excess, because of impaired intracellular trafficking and plasma membrane targeting.	Folic Acid	165-171	solute carrier family 19 member 1	Homo sapiens	67-71
24818887-1	2014	Folate (FA) modified amphiphilic linoleic acid (LA) and poly (beta-malic acid) (PMLA) double grafted chitosan (LMC) nanoparticles (NPs) with optimum grafting degrees of hydrophobic LA and hydrophilic PMLA were developed for the co-delivery of paclitaxel (PTX) and survivin shRNA-expressing plasmid (iSur-pDNA).	Folic Acid	0-6	baculoviral IAP repeat-containing 5	Mus musculus	264-272
25181322-4	2014	Folate-targeted nanoparticles were specifically internalized by glioma, imparting superior toxicity and curbed an aggressively proliferating in vitro 3D cancer mass in addition to suppressing the anti-apoptotic survivin and cell matrix protein vinculin.	Folic Acid	0-6	vinculin	Homo sapiens	244-252
24817375-9	2014	CONCLUSIONS: Folate nonresponsiveness could be attributed in part to increased noggin expression in Fkbp8 (-/-) embryos, resulting in decreased Msx2 expression.	Folic Acid	13-19	msh homeobox 2	Mus musculus	144-148
25195129-5	2014	MAM-2201 and JWH-122 produced common metabolites, N-5-hydroxylated, N-4-hydroxylated and carboxylated JWH-122 metabolites.	Folic Acid	68-71	sarcoglycan gamma	Homo sapiens	0-3
24760553-7	2014	The approach used to analyze genetic association with the SAM/SAH metabolites is called middle-out: SNPs in 275 genes involved in the one-carbon pathway (folate, pyridoxal/pyridoxine, thiamin) or were correlated with SAM/SAH (vitamin A, E, Hcy) were analyzed instead of the entire 1M SNP data set.	Folic Acid	154-160	acyl-CoA synthetase medium chain family member 3	Homo sapiens	58-65
25196122-1	2014	We report de novo occurrence of the 7p11.2 folate-sensitive fragile site FRA7A in a male with an autistic spectrum disorder (ASD) due to a CGG-repeat expansion mutation (~450 repeats) in a 5" intron of ZNF713.	Folic Acid	43-49	zinc finger protein 713	Homo sapiens	202-208
25059370-7	2014	FHIT gene DNA methylation showed all positive at the folate concentration levels of 1 microg/ml and 10 microg/ml, partially positive at 100 microg/ml and 250 microg/ml, but negative at 500 microg/ml and 1 000 microg/ml in both C33A and CaSki cells.	Folic Acid	53-59	fragile histidine triad diadenosine triphosphatase	Homo sapiens	0-4
25310577-8	2014	There was evidence of gene-environment interaction for risk genotype at IKZF1, whereby an apparently stronger genetic effect was observed if the mother took folic acid or if the father did not smoke prior to pregnancy (respective interaction P-values: 0.04, 0.05).	Folic Acid	157-167	IKAROS family zinc finger 1	Homo sapiens	72-77
25310577-11	2014	If interaction of folic acid supplementation and IKZF1 variants holds, it may be useful to quantify folate levels prior to initiating use of folic acid supplements.	Folic Acid	100-106	IKAROS family zinc finger 1	Homo sapiens	49-54
25059370-9	2014	CONCLUSION: Our findings indicated that adequate folate seemed to be able to effectively inhibit the proliferation of cervical cancer cells and facilitate their apoptosis in vitro, so would reverse the aberration mRNA and protein expression of FHIT gene.	Folic Acid	49-55	fragile histidine triad diadenosine triphosphatase	Homo sapiens	244-248
25310577-11	2014	If interaction of folic acid supplementation and IKZF1 variants holds, it may be useful to quantify folate levels prior to initiating use of folic acid supplements.	Folic Acid	141-151	IKAROS family zinc finger 1	Homo sapiens	49-54
23912258-1	2014	INTRODUCTION: RFC is the major transport system in mammalian cells for folate cofactors and antifolate therapeutics.	Folic Acid	71-77	solute carrier family 19 member 1	Homo sapiens	14-17
24326202-7	2014	5-Methyltetrahydrofolate-homocysteine methyltransferase (MTHM) 501A&gt;G in case of GDM, and betaine-homocysteine methyltransferase (BHMT) 716G&gt;A in case of no folate supplementation significantly associated with NTDs (both P&lt;.05), whereas the two genotypes alone did not significantly associate with NTDs (both P&gt;.05).	Folic Acid	18-24	betaine--homocysteine S-methyltransferase	Homo sapiens	133-137
25037819-0	2014	Folate supplementation modifies CCAAT/enhancer-binding protein alpha methylation to mediate differentiation of preadipocytes in chickens.	Folic Acid	0-6	CCAAT/enhancer binding protein alpha	Gallus gallus	32-68
24345855-0	2014	Folate conjugated silk fibroin nanocarriers for targeted drug delivery.	Folic Acid	0-6	fibroin light chain	Bombyx mori	23-30
25037819-6	2014	Folate caused a dose-dependent decrease in transcript abundance of peroxisome proliferator-activated receptor gamma (PPARgamma), CCAAT/enhancer-binding protein alpha (C/EBPalpha) gene expression, and the downstream enzyme fatty acid synthase; in contrast, expression of DNA (cytosine-5)-methyltransferase and methylenetetrahydrofolate reductase was obviously upregulated at d 6 of differentiation (P &lt; 0.05).	Folic Acid	0-6	peroxisome proliferator-activated receptor gamma	Gallus gallus	67-115
25037819-6	2014	Folate caused a dose-dependent decrease in transcript abundance of peroxisome proliferator-activated receptor gamma (PPARgamma), CCAAT/enhancer-binding protein alpha (C/EBPalpha) gene expression, and the downstream enzyme fatty acid synthase; in contrast, expression of DNA (cytosine-5)-methyltransferase and methylenetetrahydrofolate reductase was obviously upregulated at d 6 of differentiation (P &lt; 0.05).	Folic Acid	0-6	peroxisome proliferator-activated receptor gamma	Gallus gallus	117-126
25037819-6	2014	Folate caused a dose-dependent decrease in transcript abundance of peroxisome proliferator-activated receptor gamma (PPARgamma), CCAAT/enhancer-binding protein alpha (C/EBPalpha) gene expression, and the downstream enzyme fatty acid synthase; in contrast, expression of DNA (cytosine-5)-methyltransferase and methylenetetrahydrofolate reductase was obviously upregulated at d 6 of differentiation (P &lt; 0.05).	Folic Acid	0-6	CCAAT/enhancer binding protein alpha	Gallus gallus	129-165
25037819-6	2014	Folate caused a dose-dependent decrease in transcript abundance of peroxisome proliferator-activated receptor gamma (PPARgamma), CCAAT/enhancer-binding protein alpha (C/EBPalpha) gene expression, and the downstream enzyme fatty acid synthase; in contrast, expression of DNA (cytosine-5)-methyltransferase and methylenetetrahydrofolate reductase was obviously upregulated at d 6 of differentiation (P &lt; 0.05).	Folic Acid	0-6	CCAAT/enhancer binding protein alpha	Gallus gallus	167-177
25037819-8	2014	Overall CpG methylation in the C/EBPalpha gene promoter region was 21.8% lower (P &lt; 0.05) and the gene"s expression was 2.7-fold higher in the absence of folate, compared with cells treated with 16 mg/L of folate, whereas methylation of the PPARgamma promoter was not affected.	Folic Acid	157-163	CCAAT/enhancer binding protein alpha	Gallus gallus	31-41
25037819-8	2014	Overall CpG methylation in the C/EBPalpha gene promoter region was 21.8% lower (P &lt; 0.05) and the gene"s expression was 2.7-fold higher in the absence of folate, compared with cells treated with 16 mg/L of folate, whereas methylation of the PPARgamma promoter was not affected.	Folic Acid	209-215	CCAAT/enhancer binding protein alpha	Gallus gallus	31-41
25037819-9	2014	Overall, the results show that folate increased the proliferation of adipocytes but reduced per-cell lipid accumulation, thereby influencing differentiation; it increased expression of genes involved in 1-carbon metabolism resulting in greater methylation of the C/EBPalpha promoter during differentiation and decreased that gene"s expression, perhaps accounting for decreased expression of PPARgamma.	Folic Acid	31-37	CCAAT/enhancer binding protein alpha	Gallus gallus	263-273
25037819-9	2014	Overall, the results show that folate increased the proliferation of adipocytes but reduced per-cell lipid accumulation, thereby influencing differentiation; it increased expression of genes involved in 1-carbon metabolism resulting in greater methylation of the C/EBPalpha promoter during differentiation and decreased that gene"s expression, perhaps accounting for decreased expression of PPARgamma.	Folic Acid	31-37	peroxisome proliferator-activated receptor gamma	Gallus gallus	391-400
24739308-6	2014	Here, we report the epistatic interaction between dhfr mutations and amplification of the gene encoding the first upstream enzyme in the folate pathway, GTP cyclohydrolase I (GCH1).	Folic Acid	137-143	GTP cyclohydrolase 1	Homo sapiens	153-173
24739308-6	2014	Here, we report the epistatic interaction between dhfr mutations and amplification of the gene encoding the first upstream enzyme in the folate pathway, GTP cyclohydrolase I (GCH1).	Folic Acid	137-143	GTP cyclohydrolase 1	Homo sapiens	175-179
24345855-4	2014	The efficiency of silk fibroin-folate nanoparticles loaded with anticancer drug doxorubicin was evaluated by analysing the cell viability, proliferation and endocytosis.	Folic Acid	31-37	fibroin light chain	Bombyx mori	23-30
24345855-5	2014	Consequently the effects of pro-inflammatory responses by cytokines such as TNF-alpha, IL-1beta and nitric oxide were checked by stimulating the macrophages with folate conjugated silk fibroin nanoparticles.	Folic Acid	162-168	fibroin light chain	Bombyx mori	185-192
24345855-6	2014	The fibroin-folate nanocarriers are nontoxic, easily taken up by cells and capable of sustained drug release.	Folic Acid	12-18	fibroin light chain	Bombyx mori	4-11
24345855-8	2014	The results show that silk fibroin-folate nanoparticles may serve as promising nanocarriers for different biomedical and nanotechnology applications in cancer research.	Folic Acid	35-41	fibroin light chain	Bombyx mori	27-34
24419320-2	2014	Such alleles are associated with a fragile site, FRAXA, a gap or constriction in the chromosome that is coincident with the repeat and is induced by folate stress or thymidylate synthase inhibitors like fluorodeoxyuridine (FdU).	Folic Acid	149-155	fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)	Homo sapiens	49-54
23794259-3	2014	The aim of this study was to evaluate the expression levels of circulating miR-22, miR-24, and miR-34a, possibly involved in folate pathway, in NSCLC patients treated with pemetrexed compared with healthy controls and to investigate their impact on patient clinical outcomes.	Folic Acid	125-131	microRNA 34a	Homo sapiens	95-102
24007195-2	2013	Here we tested the hypothesis that biotin and folate synergize in the repression of pro-inflammatory cytokines and long-terminal repeats (LTRs), mediated by interactions between HLCS and other chromatin proteins.	Folic Acid	46-52	holocarboxylase synthetase	Homo sapiens	178-182
24710923-6	2014	It was found that transient folate deprivation combined with SMs was sufficient to permit reprogramming from mouse embryonic fibroblasts (MEFs) in the presence of transcription factors, Oct4 and Klf4, within 25 days, replacing Sox2 and c-Myc, and accelerated the generation of mouse iPSCs.	Folic Acid	28-34	POU domain, class 5, transcription factor 1, related sequence 1	Mus musculus	186-190
24446917-1	2014	The folate receptor (FR) is a GPI anchored cell surface glycoprotein that functions to facilitate folic acid uptake and mediate signal transduction.	Folic Acid	98-108	glucose-6-phosphate isomerase	Homo sapiens	30-33
24007195-8	2013	We conclude that biotin and folate synergize in the repression of LTRs and that these interactions are probably mediated by HLCS-dependent epigenetic mechanisms.	Folic Acid	28-34	holocarboxylase synthetase	Homo sapiens	124-128
24074862-2	2013	The enzyme methionine synthase reductase (Mtrr) is necessary for utilization of methyl groups from the folate cycle.	Folic Acid	103-109	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Mus musculus	11-40
24524072-4	2014	The active form of vitamin B6, pyridoxal 5-phosphate, is, besides its antioxidative properties, a cofactor for a variety of essential enzymes present in the malaria parasite which includes the ornithine decarboxylase (ODC, synthesis of polyamines), the aspartate aminotransferase (AspAT, involved in the protein biosynthesis), and the serine hydroxymethyltransferase (SHMT, a key enzyme within the folate metabolism).	Folic Acid	398-404	ornithine decarboxylase 1	Homo sapiens	193-216
24175976-7	2013	Furthermore, Fol-c1-beta-CyD accelerated cellular uptake of DOX and inhibited its efflux from KB cells.	Folic Acid	13-16	cytochrome b-245, beta polypeptide	Mus musculus	25-28
23820268-0	2013	Folic acid reverses nitric oxide synthase uncoupling and prevents cardiac dysfunction in insulin resistance: role of Ca2+/calmodulin-activated protein kinase II.	Folic Acid	0-10	nitric oxide synthase 1, neuronal	Mus musculus	20-41
23806361-1	2013	Folate transporters, including the reduced folate carrier and the proton-coupled folate transporter, encoded by Slc19a1 and Slc46a1 genes respectively, play important roles in the transport of folate across biological membranes given the hydrophilic nature of folates.	Folic Acid	43-49	solute carrier family 46 member 1	Gallus gallus	124-131
23806361-1	2013	Folate transporters, including the reduced folate carrier and the proton-coupled folate transporter, encoded by Slc19a1 and Slc46a1 genes respectively, play important roles in the transport of folate across biological membranes given the hydrophilic nature of folates.	Folic Acid	81-87	solute carrier family 46 member 1	Gallus gallus	124-131
23806361-1	2013	Folate transporters, including the reduced folate carrier and the proton-coupled folate transporter, encoded by Slc19a1 and Slc46a1 genes respectively, play important roles in the transport of folate across biological membranes given the hydrophilic nature of folates.	Folic Acid	260-267	solute carrier family 46 member 1	Gallus gallus	124-131
23806361-10	2013	Moreover, the expression of Slc19a1 and Slc46a1 transcripts in the cecum provides evidence of the potential for cecally derived folate to contribute to the folate status of the host.	Folic Acid	128-134	solute carrier family 46 member 1	Gallus gallus	40-47
23806361-10	2013	Moreover, the expression of Slc19a1 and Slc46a1 transcripts in the cecum provides evidence of the potential for cecally derived folate to contribute to the folate status of the host.	Folic Acid	156-162	solute carrier family 46 member 1	Gallus gallus	40-47
24340890-12	2013	In people without cognitive impairment (CDR 0) levels of folic acid were significantly higher compared to the group with moderate dementia (CDR 2, p = 0.0475).	Folic Acid	57-67	cerebellar degeneration related protein 2	Homo sapiens	140-145
23904512-2	2013	Folates are generally taken up into cells by specific transporters, mainly the reduced folate carrier RFC1 (SLC19A1 protein) and the high-affinity folate receptors FOLR1 and FOLR2.	Folic Acid	0-7	folate receptor 2 (fetal)	Mus musculus	174-179
24013316-2	2013	DISCUSSION: The beneficial effect of periconceptional folic acid on NTD prevention denotes a vital role for the single-carbon biochemical pathway in NTD genesis.	Folic Acid	54-64	fuzzy planar cell polarity protein	Homo sapiens	68-71
24013316-2	2013	DISCUSSION: The beneficial effect of periconceptional folic acid on NTD prevention denotes a vital role for the single-carbon biochemical pathway in NTD genesis.	Folic Acid	54-64	fuzzy planar cell polarity protein	Homo sapiens	149-152
23842564-18	2013	At follow-up, 22% in the IG, 3% in CG1 and 1% in CG2 mentioned folic acid intake (P &lt; 0.001).	Folic Acid	63-73	transmembrane protein 245	Homo sapiens	49-52
23863605-3	2013	F26G3 IgG3 MuAb binds PGA with a relatively high functional affinity (10 nM), produces a distinct "rim" quellung reaction, and is protective in a murine model of pulmonary anthrax.	Folic Acid	22-25	Immunoglobulin heavy constant gamma 3	Mus musculus	6-10
23803888-4	2013	In our studies of a mouse model that develops intestinal tumors after low dietary folate, we found reduced BCMO1 expression in normal preneoplastic intestine of folate-deficient tumor-prone mice.	Folic Acid	82-88	beta-carotene oxygenase 1	Mus musculus	107-112
23803888-4	2013	In our studies of a mouse model that develops intestinal tumors after low dietary folate, we found reduced BCMO1 expression in normal preneoplastic intestine of folate-deficient tumor-prone mice.	Folic Acid	161-167	beta-carotene oxygenase 1	Mus musculus	107-112
23645037-3	2013	Betaine-homocysteine methyltransferase (BHMT) is a key enzyme of folate pathway, and catalyzes the remethylation of homocysteine into methionine.	Folic Acid	65-71	betaine--homocysteine S-methyltransferase	Homo sapiens	0-38
23645037-3	2013	Betaine-homocysteine methyltransferase (BHMT) is a key enzyme of folate pathway, and catalyzes the remethylation of homocysteine into methionine.	Folic Acid	65-71	betaine--homocysteine S-methyltransferase	Homo sapiens	40-44
23964315-8	2013	Positive correlations were found between the hepatic folate content and global DNA methylation and protein expressions of FRalpha, IGF-2 and IGF-1R, whereas an inverse correlation was found between hepatic folate content and plasma homocysteine level in the 3-week-old rat pup.	Folic Acid	53-59	insulin-like growth factor 1 receptor	Rattus norvegicus	141-147
23857226-1	2013	A common polymorphism (c.80A&gt;G) in the gene coding for the reduced folate carrier (SLC19A1, commonly known as RFC-1) has been associated with maternal risk of the birth of a child with Down Syndrome (DS), but results are controversial.	Folic Acid	70-76	solute carrier family 19 member 1	Homo sapiens	86-93
23562047-0	2013	Targeting CCL21-folic acid-upconversion nanoparticles conjugates to folate receptor-alpha expressing tumor cells in an endothelial-tumor cell bilayer model.	Folic Acid	16-26	C-C motif chemokine ligand 21	Homo sapiens	10-15
23873812-2	2013	The present study evaluated how folic acid knowledge and periconceptional use for NTD prevention varies by ethnicity in the United Kingdom (U.K.).	Folic Acid	32-42	fuzzy planar cell polarity protein	Homo sapiens	82-85
23935743-0	2013	Effect of folic acid and vitamin B12 on the expression of PPARgamma, caspase-3 and caspase-8 mRNA in the abdominal aortas of rats with hyperlipidemia.	Folic Acid	10-20	caspase 3	Rattus norvegicus	69-78
24757762-3	2014	The feasibility of folate targeting to detect atherosclerosis was demonstrated in human and mouse plaques, and it was suggested that molecular imaging of FR-beta through folate conjugates might be a specific marker for plaque vulnerability.	Folic Acid	170-176	folate receptor 2 (fetal)	Mus musculus	154-161
23537880-5	2013	Dual-conjugated liposomes with folate and molecular beacon enabled fluorescence imaging of cancer cells harboring the AIMP2-DX2 mutation with high resolution.	Folic Acid	31-37	aminoacyl tRNA synthetase complex interacting multifunctional protein 2	Homo sapiens	118-123
23935743-2	2013	In order to prevent and mitigate the high-fat state that results from endothelial injury, this study examined the effect of folic acid (FA) and vitamin B12 (VB12) on the expression of PPARgamma and caspase-3 and -8 mRNA in the abdominal aortas of rats with hyperlipidemia.	Folic Acid	124-134	caspase 3	Rattus norvegicus	198-214
23684804-8	2013	The effects of the MTHFD1 mutation were less pronounced when combined with a deficient diet, suggesting a compensatory mechanism to the combined genetic and dietary perturbation of folate metabolism.	Folic Acid	181-187	methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase	Mus musculus	19-25
23412628-1	2013	PURPOSE: We examined whether the novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate, compound 2, might be an effective treatment for malignant pleural mesothelioma (MPM), reflecting its selective membrane transport by the proton-coupled folate transport (PCFT) over the reduced folate carrier (RFC).	Folic Acid	91-97	solute carrier family 19 member 1	Homo sapiens	308-311
23599757-0	2013	Polymorphisms in thymidylate synthase and reduced folate carrier (SLC19A1) genes predict survival outcome in advanced non-small cell lung cancer patients treated with pemetrexed-based chemotherapy.	Folic Acid	50-56	solute carrier family 19 member 1	Homo sapiens	66-73
23307533-3	2013	Conversely, higher folate intake has been inversely associated with liver damage and HCC.	Folic Acid	19-25	HCC	Homo sapiens	85-88
23307533-4	2013	In the current study, we investigate the effect of alcohol consumption and folate intake on HCC incidence and liver disease mortality in the NIH-American Association of Retired Persons Diet and Health Study.	Folic Acid	75-81	HCC	Homo sapiens	92-95
23307533-9	2013	Folate, however, modified the relationship between alcohol and HCC incidence (Pinteraction = 0.03), but had no effect on the relationship between alcohol and liver disease mortality (Pinteraction = 0.54).	Folic Acid	0-6	HCC	Homo sapiens	63-66
23307533-10	2013	CONCLUSIONS: These results suggest that higher folate intake may ameliorate the effect of alcohol consumption on the development of HCC.	Folic Acid	47-53	HCC	Homo sapiens	132-135
23307533-11	2013	IMPACT: Folate intake may be beneficial in the prevention of alcohol-associated HCC.	Folic Acid	8-14	HCC	Homo sapiens	80-83
22161782-5	2013	With gemcitabine, folate-G5-PAMAM-D delivered PSMAe/p-TK-Cx43 (folate-G5-PAMAM-D/PSMAe/p-TK-Cx43) significantly decreased prostate cancer LNCaP cell proliferation and promoted apoptosis in vitro.	Folic Acid	18-24	gap junction protein alpha 1	Homo sapiens	57-61
22161782-5	2013	With gemcitabine, folate-G5-PAMAM-D delivered PSMAe/p-TK-Cx43 (folate-G5-PAMAM-D/PSMAe/p-TK-Cx43) significantly decreased prostate cancer LNCaP cell proliferation and promoted apoptosis in vitro.	Folic Acid	18-24	gap junction protein alpha 1	Homo sapiens	92-96
22161782-5	2013	With gemcitabine, folate-G5-PAMAM-D delivered PSMAe/p-TK-Cx43 (folate-G5-PAMAM-D/PSMAe/p-TK-Cx43) significantly decreased prostate cancer LNCaP cell proliferation and promoted apoptosis in vitro.	Folic Acid	63-69	gap junction protein alpha 1	Homo sapiens	57-61
22161782-5	2013	With gemcitabine, folate-G5-PAMAM-D delivered PSMAe/p-TK-Cx43 (folate-G5-PAMAM-D/PSMAe/p-TK-Cx43) significantly decreased prostate cancer LNCaP cell proliferation and promoted apoptosis in vitro.	Folic Acid	63-69	gap junction protein alpha 1	Homo sapiens	92-96
22161782-6	2013	With gemcitabine, the systemic deliver of folate-G5-PAMAM-D/PSMAe/p-TK-Cx43 significantly inhibited tumor growth in the LNCaP xenograft animal model.	Folic Acid	42-48	gap junction protein alpha 1	Homo sapiens	71-75
23178654-0	2013	Folic acid inhibits endothelial cell migration through inhibiting the RhoA activity mediated by activating the folic acid receptor/cSrc/p190RhoGAP-signaling pathway.	Folic Acid	0-10	Rho GTPase activating protein 35	Homo sapiens	136-146
23641923-2	2013	Because pro-inflammatory macrophages have also been shown to overexpress a receptor for the vitamin folic acid (i.e., folate receptor beta; FR-beta), folate-linked drugs have been explored for use in imaging and treatment of these same diseases.	Folic Acid	118-124	folate receptor 2 (fetal)	Mus musculus	140-147
23519469-10	2013	Importantly, folate withdrawal also induced CerS6/C16-ceramide elevation accompanied by p53 accumulation.	Folic Acid	13-19	ceramide synthase 6	Homo sapiens	44-49
24074862-2	2013	The enzyme methionine synthase reductase (Mtrr) is necessary for utilization of methyl groups from the folate cycle.	Folic Acid	103-109	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Mus musculus	42-46
23408242-0	2013	Adverse placental effect of formic acid on hCG secretion is mitigated by folic acid.	Folic Acid	73-83	hypertrichosis 2 (generalised, congenital)	Homo sapiens	43-46
23408242-8	2013	The addition of folic acid to the perfusate mitigated the decrease in hCG.	Folic Acid	16-26	hypertrichosis 2 (generalised, congenital)	Homo sapiens	70-73
23803214-0	2013	[Effect of folic acid in preventing aberrant methylation of fetal endometriosis susceptibility gene HOXA10].	Folic Acid	11-21	homeobox A10	Homo sapiens	100-106
23313250-4	2013	The aim of this study was to study in vitro the possible effect of different concentrations of 5-methyltetrahydrofolic acid (5-MTHF) or folic acid on NK cell cytotoxic function, and expression of the stimulatory and inhibitory receptors KIRDL4, KIRDL3, and NKG2D.	Folic Acid	113-123	killer cell lectin like receptor K1	Homo sapiens	257-262
23803214-1	2013	OBJECTIVE: To detect aberrant methylation in the promoter region of fetal endometriosis susceptibility gene homeobox-10 (HOXA10) in women with and without folic acid supplementation and explore the effect of folic acid in optimizing intrauterine environment.	Folic Acid	155-165	homeobox A10	Homo sapiens	121-127
23803214-4	2013	RESULTS: The methylation rate of HOXA10 gene differed significantly between pregnant women with endometriosis taking folic acid and those who did (P&lt;0.05).	Folic Acid	117-127	homeobox A10	Homo sapiens	33-39
23803214-5	2013	CONCLUSION: Folic acid treatment can significantly reduce the methylation rate of fetal endometriosis susceptibility gene HOXA10.	Folic Acid	12-22	homeobox A10	Homo sapiens	122-128
22932126-7	2013	PB1 extrusion and GVBD percentages rose to 27 7 and 40 0% from 12 8 and 19 9%, respectively, by exposure to 500 muM-folic acid.	Folic Acid	116-126	polybromo 1	Mus musculus	0-3
23519469-0	2013	Folate stress induces apoptosis via p53-dependent de novo ceramide synthesis and up-regulation of ceramide synthase 6.	Folic Acid	0-6	ceramide synthase 6	Homo sapiens	98-117
23408242-10	2013	Formic acid decreases hCG secretion in the placenta, which may alter steroidogenesis and differentiation of the cytotrophoblasts, and this adverse effect can be mitigated by folate.	Folic Acid	174-180	hypertrichosis 2 (generalised, congenital)	Homo sapiens	22-25
23506878-2	2013	SLC19A1 transports folates but not thiamine.	Folic Acid	19-26	solute carrier family 19 member 1	Homo sapiens	0-7
23539757-4	2013	In the folic acid nephrotoxicity model of acute tubular necrosis, mice expressing KCP survived high doses of folic acid that were lethal for wild-type mice.	Folic Acid	7-17	kielin/chordin-like protein	Mus musculus	82-85
23427344-3	2013	METHODS: To determine the proportion of NTD cases that is attributable to known or suspected risk factors (i.e., female infant sex, family history of NTDs, and maternal Hispanic ethnicity, obesity, pregestational diabetes, gestational diabetes, low dietary folate intake, lack of folic acid supplementation, anticonvulsant use, and hot tub or sauna use), we estimated the adjusted population attributable fraction (aAF) for each factor, using the method of Eide and Geffler and data from the National Birth Defects Prevention Study.	Folic Acid	257-263	fuzzy planar cell polarity protein	Homo sapiens	40-43
23427344-3	2013	METHODS: To determine the proportion of NTD cases that is attributable to known or suspected risk factors (i.e., female infant sex, family history of NTDs, and maternal Hispanic ethnicity, obesity, pregestational diabetes, gestational diabetes, low dietary folate intake, lack of folic acid supplementation, anticonvulsant use, and hot tub or sauna use), we estimated the adjusted population attributable fraction (aAF) for each factor, using the method of Eide and Geffler and data from the National Birth Defects Prevention Study.	Folic Acid	280-290	fuzzy planar cell polarity protein	Homo sapiens	40-43
23539757-4	2013	In the folic acid nephrotoxicity model of acute tubular necrosis, mice expressing KCP survived high doses of folic acid that were lethal for wild-type mice.	Folic Acid	109-119	kielin/chordin-like protein	Mus musculus	82-85
23539757-5	2013	With a lower dose of folic acid, mice expressing KCP exhibited improved renal recovery compared with wild-type mice.	Folic Acid	21-31	kielin/chordin-like protein	Mus musculus	49-52
23449276-4	2013	Increased activity of pemetrexed occurs by folylpolyglutamate synthetase (FPGS), intracellular transport by reduced folate carrier (RFC).	Folic Acid	116-122	solute carrier family 19 member 1	Homo sapiens	132-135
24007422-2	2013	Since introduction of mandatory fortification of grains with folic acid, a further decrease in NTD prevalence has been reported in North America and other countries with large variations among ethnic subgroups.	Folic Acid	61-71	fuzzy planar cell polarity protein	Homo sapiens	95-98
24007422-6	2013	Besides folate, several other lifestyle and environmental factors as well as genetic variations may influence NTD development, possibly by affecting one-carbon metabolism and thus epigenetic events.	Folic Acid	8-14	fuzzy planar cell polarity protein	Homo sapiens	110-113
24007422-7	2013	In conclusion, mandatory folic acid fortification plays a significant part in the reduction of NTD prevalence, but possibly at a cost and with a portion of NTDs remaining.	Folic Acid	25-35	fuzzy planar cell polarity protein	Homo sapiens	95-98
23449276-15	2013	Folate uptake mechanisms by RFC and activation by FPGS were associated with clinical benefit from pemetrexed treatment.	Folic Acid	0-6	solute carrier family 19 member 1	Homo sapiens	28-31
23364519-6	2013	PTHrP(1-36) protected renal tubuloepithelial cells from folic acid toxicity and serum deprivation, an effect inhibited by a dominant-negative Runx2 construct or a Runx2 siRNA.	Folic Acid	56-66	parathyroid hormone like hormone	Homo sapiens	0-5
23573162-8	2013	The increased aortic vascular cell adhesion molecule-1 expression in the methionine group (2.58 +- 0.29) was significantly reduced by the folate (1.38 +- 0.18) and palm TRF at 150 mg/kg (1.19 +- 0.23).	Folic Acid	138-144	vascular cell adhesion molecule 1	Rattus norvegicus	21-54
23346361-1	2013	To obtain a tumor cell-selectivity of methyl-beta-cyclodextrin (M-beta-CyD), we newly synthesized folate-appended M-beta-CyD (FA-M-beta-CyD), and evaluated the potential of FA-M-beta-CyD as a novel anticancer agent in vitro and in vivo.	Folic Acid	98-104	cytochrome b-245, beta polypeptide	Mus musculus	71-74
23346361-1	2013	To obtain a tumor cell-selectivity of methyl-beta-cyclodextrin (M-beta-CyD), we newly synthesized folate-appended M-beta-CyD (FA-M-beta-CyD), and evaluated the potential of FA-M-beta-CyD as a novel anticancer agent in vitro and in vivo.	Folic Acid	98-104	cytochrome b-245, beta polypeptide	Mus musculus	121-124
23346361-1	2013	To obtain a tumor cell-selectivity of methyl-beta-cyclodextrin (M-beta-CyD), we newly synthesized folate-appended M-beta-CyD (FA-M-beta-CyD), and evaluated the potential of FA-M-beta-CyD as a novel anticancer agent in vitro and in vivo.	Folic Acid	98-104	cytochrome b-245, beta polypeptide	Mus musculus	121-124
23346361-1	2013	To obtain a tumor cell-selectivity of methyl-beta-cyclodextrin (M-beta-CyD), we newly synthesized folate-appended M-beta-CyD (FA-M-beta-CyD), and evaluated the potential of FA-M-beta-CyD as a novel anticancer agent in vitro and in vivo.	Folic Acid	98-104	cytochrome b-245, beta polypeptide	Mus musculus	121-124
22828209-0	2012	Mechanism of folate deficiency-induced apoptosis in mouse embryonic stem cells: Cell cycle arrest/apoptosis in G1/G0 mediated by microRNA-302a and tumor suppressor gene Lats2.	Folic Acid	13-19	large tumor suppressor 2	Mus musculus	169-174
22828209-8	2012	Furthermore, bioinformatics analyses and in vitro studies suggested that miR-302a plays a critical role in mediating the effects of folate on cell proliferation and cell cycle-specific apoptosis by targeting Lats2 gene.	Folic Acid	132-138	large tumor suppressor 2	Mus musculus	208-213
23287122-10	2012	The observed upregulation was associated with significant increase in reduced folate carrier (RFC) and proton coupled folate transporter (PCFT) expressions, suggesting the transcriptional and translational regulation of folate uptake during folate deficiency.	Folic Acid	78-84	solute carrier family 46 member 1	Rattus norvegicus	138-142
23287122-10	2012	The observed upregulation was associated with significant increase in reduced folate carrier (RFC) and proton coupled folate transporter (PCFT) expressions, suggesting the transcriptional and translational regulation of folate uptake during folate deficiency.	Folic Acid	118-124	solute carrier family 46 member 1	Rattus norvegicus	138-142
23287122-10	2012	The observed upregulation was associated with significant increase in reduced folate carrier (RFC) and proton coupled folate transporter (PCFT) expressions, suggesting the transcriptional and translational regulation of folate uptake during folate deficiency.	Folic Acid	118-124	solute carrier family 46 member 1	Rattus norvegicus	138-142
24552105-5	2012	Epigenetic mechanisms of folate deficiency are illustrated by inheritance of coat colour of agouti mice model and altered expression of Igf2/H19 imprinting genes.	Folic Acid	25-31	H19, imprinted maternally expressed transcript	Mus musculus	141-144
24552105-7	2012	Deficiency in folate and vitamin B12 produces impaired fatty acid oxidation in liver and heart through imbalanced methylation and acetylation of PGC1-alpha and decreased expression of SIRT1, and long-lasting cognitive disabilities through impaired hippocampal cell proliferation, differentiation and plasticity and atrophy of hippocampal CA1.	Folic Acid	14-20	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	145-155
22865158-6	2012	The renal folate uptake process is saturable and pH dependent, and it involves the folate receptor and reduced folate carrier (RFC) systems and possibly the proton coupled folate transporter (PCFT) system.	Folic Acid	10-16	solute carrier family 46 member 1	Rattus norvegicus	157-190
22865158-6	2012	The renal folate uptake process is saturable and pH dependent, and it involves the folate receptor and reduced folate carrier (RFC) systems and possibly the proton coupled folate transporter (PCFT) system.	Folic Acid	10-16	solute carrier family 46 member 1	Rattus norvegicus	192-196
23059056-10	2012	The regression model revealed interactions between genotype and case-control status in the association of total plasma folate, total glutathione (GSH), and free GSH, to SNPs within the MGMT, 5,10-methenyltetrahydrofolate synthetase (MTHFS), and catalase (CAT) genes, respectively.	Folic Acid	119-125	methenyltetrahydrofolate synthetase	Homo sapiens	191-231
22325970-5	2012	Quantitative methylated DNA immunoprecipitation (qMeDIP) and quantitative methylated specific PCR (qMSP) analysis of methylation status showed that folate treatment, increased the methylation level of DNA repeat elements in tumour and in colorectal tissue and that of MGMT and specific oncogenes (PDGF-B or survivin) in tumours (but not in colorectal tissue), but had no effect on the expression of tumour suppressor genes (p53, PTENorbax) in tumours or in colorectal tissue.	Folic Acid	148-154	O-6-methylguanine-DNA methyltransferase	Mus musculus	268-272
22325970-5	2012	Quantitative methylated DNA immunoprecipitation (qMeDIP) and quantitative methylated specific PCR (qMSP) analysis of methylation status showed that folate treatment, increased the methylation level of DNA repeat elements in tumour and in colorectal tissue and that of MGMT and specific oncogenes (PDGF-B or survivin) in tumours (but not in colorectal tissue), but had no effect on the expression of tumour suppressor genes (p53, PTENorbax) in tumours or in colorectal tissue.	Folic Acid	148-154	baculoviral IAP repeat-containing 5	Mus musculus	307-315
23798054-3	2012	Optimal folate status has an established role in preventing NTD and there is strong evidence indicating that it also has a role in the primary prevention of stroke.	Folic Acid	8-14	fuzzy planar cell polarity protein	Homo sapiens	60-63
22764226-6	2012	In the folate-deficient mouse model, L-dopa resulted in a marked depletion of SAM and an increase in SAH in various brain regions with parallel downregulation of PP2A methylation and increased Tau phosphorylation.	Folic Acid	7-13	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	Mus musculus	162-166
22693311-2	2012	Unfortunately, folic acid and folate-linked drugs bind equally well to both major isoforms of the FR-that is, FR-alpha, which is primarily expressed on malignant cells, and FR-beta, which is upregulated on activated monocytes and macrophages.	Folic Acid	15-25	folate receptor 2 (fetal)	Mus musculus	173-180
22693311-2	2012	Unfortunately, folic acid and folate-linked drugs bind equally well to both major isoforms of the FR-that is, FR-alpha, which is primarily expressed on malignant cells, and FR-beta, which is upregulated on activated monocytes and macrophages.	Folic Acid	30-36	folate receptor 2 (fetal)	Mus musculus	173-180
22378735-1	2012	BACKGROUND: MTHFD1 encodes C1-tetrahydrofolate synthase, which is a folate-dependent enzyme that catalyzes the formation and interconversion of folate-activated one-carbon groups for nucleotide biosynthesis and cellular methylation.	Folic Acid	40-46	methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase	Mus musculus	12-18
22378735-1	2012	BACKGROUND: MTHFD1 encodes C1-tetrahydrofolate synthase, which is a folate-dependent enzyme that catalyzes the formation and interconversion of folate-activated one-carbon groups for nucleotide biosynthesis and cellular methylation.	Folic Acid	68-74	methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase	Mus musculus	12-18
22378735-1	2012	BACKGROUND: MTHFD1 encodes C1-tetrahydrofolate synthase, which is a folate-dependent enzyme that catalyzes the formation and interconversion of folate-activated one-carbon groups for nucleotide biosynthesis and cellular methylation.	Folic Acid	68-74	methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase	Mus musculus	27-55
22378735-3	2012	OBJECTIVE: The objective of this study was to determine whether disruption of the embryonic or maternal Mthfd1 gene or both interacts with impaired folate and choline status to affect neural tube closure, fetal growth, and fertility in mice and to investigate the underlying metabolic disruptions.	Folic Acid	148-154	methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase	Mus musculus	104-110
22378735-7	2012	RESULTS: Reduced folate and choline status resulted in severe fetal growth restriction (FGR) and impaired fertility in litters harvested from Mthfd1(gt/+) dams, but embryonic Mthfd1(gt/+) genotype did not affect fetal growth.	Folic Acid	17-23	methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase	Mus musculus	142-148
22378735-9	2012	Mthfd1(gt/+) dams exhibited lower red blood cell folate and plasma methionine concentrations than did wild-type dams.	Folic Acid	49-55	methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase	Mus musculus	0-6
22378735-12	2012	Mthfd1 heterozygosity impairs folate status in pregnant mice but does not significantly affect homocysteine metabolism.	Folic Acid	30-36	methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase	Mus musculus	0-6
22147198-3	2012	Overexpression of GGH and downregulation of FPGS would be expected to decrease intracellular folate in its polyglutamylated form, thereby increasing efflux of folate and its related molecules, which might lead to resistance to drugs or folate deficiency.	Folic Acid	93-99	gamma-glutamyl hydrolase	Rattus norvegicus	18-21
22147198-3	2012	Overexpression of GGH and downregulation of FPGS would be expected to decrease intracellular folate in its polyglutamylated form, thereby increasing efflux of folate and its related molecules, which might lead to resistance to drugs or folate deficiency.	Folic Acid	159-165	gamma-glutamyl hydrolase	Rattus norvegicus	18-21
22147198-4	2012	The study was sought to delineate the activity of GGH and expression FPGS in tissues involved in folate homeostasis during alcoholism and the epigenetic regulation of these enzymes and transporters regulating intracellular folate levels.	Folic Acid	97-103	gamma-glutamyl hydrolase	Rattus norvegicus	50-53
22147198-4	2012	The study was sought to delineate the activity of GGH and expression FPGS in tissues involved in folate homeostasis during alcoholism and the epigenetic regulation of these enzymes and transporters regulating intracellular folate levels.	Folic Acid	223-229	gamma-glutamyl hydrolase	Rattus norvegicus	50-53
22147198-11	2012	In conclusion, the initial deconjugation of polyglutamylated folate by GGH was not impaired in ethanol-fed rats while the conversion of monoglutamylated folate to polyglutamylated form might be impaired.	Folic Acid	61-67	gamma-glutamyl hydrolase	Rattus norvegicus	71-74
21946912-9	2012	Interaction between folate consumption, drinking, and ALDH2 genotype was remarkable (three-way interaction, P&lt;0.001).	Folic Acid	20-26	aldehyde dehydrogenase 2 family member	Homo sapiens	54-59
21946912-10	2012	We observed significant interaction among folate, drinking, and ALDH2 genotype in the Japanese population.	Folic Acid	42-48	aldehyde dehydrogenase 2 family member	Homo sapiens	64-69
22377700-5	2012	The polymorphisms MTHFR c.677C&gt;T and solute carrier family 19 (folate transporter), member 1 (SLC19A1) c.80 A&gt;G modulate folate concentrations, whereas the 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR) c.66A&gt;G polymorphism affects the MMA concentration.	Folic Acid	66-72	solute carrier family 19 member 1	Homo sapiens	97-104
22083158-10	2012	Intriguingly, restoration of dihydrofolate reductase expression by oral administration of folic acid or overexpression of dihydrofolate reductase completely prevented AAA formation in Ang II-infused hph-1 mice while attenuating progressive uncoupling of eNOS.	Folic Acid	90-100	hyperphenylalaninemia 1	Mus musculus	199-204
22083158-11	2012	Folic acid also attenuated vascular remodeling and inflammation characterized by medial elastin breakdown and augmented matrix metalloproteinase 2 activity and activation of matrix metalloproteinase 9, as well as macrophage infiltration.	Folic Acid	0-10	matrix metallopeptidase 9	Mus musculus	174-200
21550412-4	2011	In addition to key roles in folate metabolism, dihydrofolate reductase (DHFR) can "recycle" BH2, and thus regenerate BH4.	Folic Acid	28-34	immunoglobulin kappa variable 1-131	Mus musculus	92-95
21719790-5	2011	In the setting of acute kidney injury induced by folic acid, the blockade or absence of TWEAK abrogated the injury-related decrease in renal and plasma Klotho levels.	Folic Acid	49-59	tumor necrosis factor (ligand) superfamily, member 12	Mus musculus	88-93
22303332-4	2011	Mthfs is not an essential gene in Arabidopsis, but MTHFS expression is elevated in animal tumors, enhances de novo purine synthesis, confers partial resistance to antifolate purine synthesis inhibitors and increases rates of folate catabolism in mammalian cell cultures.	Folic Acid	167-173	methenyltetrahydrofolate synthetase	Homo sapiens	51-56
21349824-6	2011	In addition, culture in folic acid increased vascular density, as determined by anti-CD31 immunostaining (P = 0.05).	Folic Acid	24-34	platelet and endothelial cell adhesion molecule 1	Homo sapiens	85-89
21349824-8	2011	This study demonstrates that folic acid is potentially important in a number of crucial early stages of placental development, including EVT invasion, angiogenesis, and secretion of MMPs, and highlights the need for further studies to address the benefit of longer-term folic acid supplementation throughout pregnancy to prevent pregnancy disorders associated with deficient placental development, including preeclampsia.	Folic Acid	29-39	matrix metallopeptidase 2	Homo sapiens	182-186
21481001-0	2011	Folic acid rescue of ATRA-induced cleft palate by restoring the TGF-beta signal and inhibiting apoptosis.	Folic Acid	0-10	transforming growth factor, beta 1	Mus musculus	64-72
21372133-10	2011	These results indicate that folinic acid conversion by MTHFS is required for bacterial intrinsic antifolate resistance and folate homeostatic control.	Folic Acid	101-107	methenyltetrahydrofolate synthetase	Homo sapiens	55-60
21281628-4	2011	Folate-deficient feeding significantly enhanced mtDNA content and overall abundance of the D-1 mtDNA deletion in brain of Ung-/-, but not of wild-type mice.	Folic Acid	0-6	uracil DNA glycosylase	Mus musculus	122-125
21556118-1	2011	The reduced folate carrier (Rfc1; Slc19a1) mediated transport of reduced folates and antifolate drugs such as methotrexate (MTX) play an essential role in physiological folate homeostasis and MTX cancer chemotherapy.	Folic Acid	12-18	solute carrier family 19 member 1	Rattus norvegicus	34-41
21556118-1	2011	The reduced folate carrier (Rfc1; Slc19a1) mediated transport of reduced folates and antifolate drugs such as methotrexate (MTX) play an essential role in physiological folate homeostasis and MTX cancer chemotherapy.	Folic Acid	73-80	solute carrier family 19 member 1	Rattus norvegicus	34-41
21556118-1	2011	The reduced folate carrier (Rfc1; Slc19a1) mediated transport of reduced folates and antifolate drugs such as methotrexate (MTX) play an essential role in physiological folate homeostasis and MTX cancer chemotherapy.	Folic Acid	73-79	solute carrier family 19 member 1	Rattus norvegicus	34-41
21876361-9	2011	Furthermore, dietary intake of folate micronutrients below the recommended daily allowance was observed in a larger percent of patients than controls with the minor BHMT allele (51% patients vs. 44% controls; p = 0.021).	Folic Acid	31-37	betaine--homocysteine S-methyltransferase	Homo sapiens	165-169
21876361-10	2011	CONCLUSIONS: In the presence of the minor BHMT allele, a decreased consumption of folate micronutrients might increase the risk of CAD.	Folic Acid	82-88	betaine--homocysteine S-methyltransferase	Homo sapiens	42-46
21760912-4	2011	The reduced folate carrier (RFC/SLC19A1) is the major transport system for folates in mammalian cells and tissues.	Folic Acid	12-18	solute carrier family 19 member 1	Homo sapiens	28-31
21760912-4	2011	The reduced folate carrier (RFC/SLC19A1) is the major transport system for folates in mammalian cells and tissues.	Folic Acid	12-18	solute carrier family 19 member 1	Homo sapiens	32-39
21760912-4	2011	The reduced folate carrier (RFC/SLC19A1) is the major transport system for folates in mammalian cells and tissues.	Folic Acid	75-82	solute carrier family 19 member 1	Homo sapiens	28-31
21760912-4	2011	The reduced folate carrier (RFC/SLC19A1) is the major transport system for folates in mammalian cells and tissues.	Folic Acid	75-82	solute carrier family 19 member 1	Homo sapiens	32-39
19737740-3	2010	OBJECTIVE: As the mechanism by which folic acid and choline supplementation prevents NCL/P is poorly understood, the relationship between 16 polymorphic variants of 12 genes encoding enzymes involved in the metabolism of these two nutrients and the risk of facial clefts was investigated.	Folic Acid	37-47	nucleolin	Homo sapiens	85-88
21215183-11	2010	In folic acid deficient group, the expressions of tbx5 and nppa were reduced while the expressions of vmhc and amhc appeared normal.	Folic Acid	3-13	myosin, heavy chain 6, cardiac muscle, alpha	Danio rerio	111-115
20729910-9	2010	Dephosphorylation of cofilin and inhibition of motility in response to FDH can also be prevented by the increased folate in media.	Folic Acid	114-120	cofilin 1	Homo sapiens	21-28
20729910-10	2010	Furthermore, folate depletion itself, in the absence of FDH, resulted in cofilin dephosphorylation and inhibition of motility in several cell lines.	Folic Acid	13-19	cofilin 1	Homo sapiens	73-80
20686069-1	2010	The proton-coupled folate transporter (PCFT-SLC46A1) is required for intestinal folate absorption and is mutated in the autosomal recessive disorder, hereditary folate malabsorption (HFM).	Folic Acid	19-25	solute carrier family 46 (folate transporter), member 1 L homeolog	Xenopus laevis	44-51
20890936-2	2010	The aim of this study was to determine the involvement of polymorphic variants in four genes (MTHFR, MTHFD1, MTR, and SLC19A1) that encode proteins related to folic acid metabolism in the women with susceptibility for having a child with NSCL/P.	Folic Acid	159-169	solute carrier family 19 member 1	Homo sapiens	118-125
20724482-11	2010	Moreover, NRF-1 silencing down-regulated genes encoding for key folate transporters and enzymes in folate metabolism.	Folic Acid	64-70	nuclear respiratory factor 1	Homo sapiens	10-15
21058067-0	2010	Proton-coupled folate transporter (PCFT): molecular cloning, tissue expression patterns and the effects of dietary folate supplementation on mRNA expression in laying hens.	Folic Acid	15-21	solute carrier family 46 member 1	Gallus gallus	35-39
21058067-2	2010	The aim was to investigate the molecular characterisation and effects of dietary folate supplementation on mRNA concentrations of the proton-coupled folate transporter (PCFT) in chicken.	Folic Acid	81-87	solute carrier family 46 member 1	Gallus gallus	169-173
20589881-7	2010	In both groups, the proportions of women who received preconception examinations and reported folic acid intake were much higher for those who reported planning their pregnancies compared to women with an unplanned pregnancy (for all, p &lt; 0.01); and for NTD prevention, synergistic interactions existed between pregnancy planning and the other preventive measures.	Folic Acid	94-104	fuzzy planar cell polarity protein	Homo sapiens	257-260
20698054-7	2010	Dietary vitamin E was associated with decreased risk of ER and PGR positive breast cancer (IRR: 0.50; 95% CI: 0.25-0.98) and dietary folate was associated with increased risk of ER and PGR positive breast cancer (IRR: 1.27; 95% CI: 1.03-1.95).	Folic Acid	133-139	progesterone receptor	Homo sapiens	185-188
20838574-7	2010	Supplementation of NSCs with folic acid increased the mRNA and protein expression levels of Notch1 and Hes5.	Folic Acid	29-39	hes family bHLH transcription factor 5	Rattus norvegicus	103-107
19879746-10	2010	Moreover, folic acid caused a reduction in PTEN (phosphatase and tensin homolog deleted on chromosome 10) expression, an increase in the phosphorylation of endothelial nitric oxide synthase (eNOS(Ser1177)) and Akt(Ser473), and an enhanced interaction of heat shock protein 90 (HSP90) with eNOS in both strains, with greater magnitude observed in +db/+db mice.	Folic Acid	10-20	heat shock protein, 3	Mus musculus	254-275
19879746-10	2010	Moreover, folic acid caused a reduction in PTEN (phosphatase and tensin homolog deleted on chromosome 10) expression, an increase in the phosphorylation of endothelial nitric oxide synthase (eNOS(Ser1177)) and Akt(Ser473), and an enhanced interaction of heat shock protein 90 (HSP90) with eNOS in both strains, with greater magnitude observed in +db/+db mice.	Folic Acid	10-20	heat shock protein, 3	Mus musculus	277-282
20703205-3	2010	Currently, identified risk factors for NTDs include a mother who previously had an NTD-affected pregnancy, maternal diabetes, obesity, hyperthermia, certain antiseizure medications, genetic variants, race/ethnicity, and nutrition (particularly folic acid insufficiency).	Folic Acid	244-254	fuzzy planar cell polarity protein	Homo sapiens	39-42
20740593-9	2010	Prevention of NTDs by maternal folate supplementation has been tested in 13 mutants and reduces NTD frequency in six diverse mutants.	Folic Acid	31-37	fuzzy planar cell polarity protein	Homo sapiens	14-17
20930345-1	2010	OBJECTIVES: To determine the awareness amongst dental students, practitioners and maxillofacial surgeons the role of folic acid in the prevention of CLAP and its clinical use.	Folic Acid	117-127	BCL10 immune signaling adaptor	Homo sapiens	149-153
20930345-4	2010	3.8 % of the population were able to correlate folic acid to CLAP while a negligible 0.03 % could provide the dosage.	Folic Acid	47-57	BCL10 immune signaling adaptor	Homo sapiens	61-65
20930345-5	2010	CONCLUSION: Educating healthcare providers and, in turn, the prospective parents on benefits folic acid would not only help in reducing the incidence of CLAP but also significantly influence the economics of the patients afflicted with CLAP disorders.	Folic Acid	93-103	BCL10 immune signaling adaptor	Homo sapiens	153-157
20489182-4	2010	Iba57p homologs occur in all domains of life; they belong to the COG0354 protein family and are structurally similar to various folate-dependent enzymes.	Folic Acid	128-134	Iba57p	Saccharomyces cerevisiae S288C	0-6
20489182-5	2010	We therefore investigated the possible relationship between folates and Fe/S cluster enzymes using the Escherichia coli Iba57p homolog, YgfZ.	Folic Acid	60-67	Iba57p	Saccharomyces cerevisiae S288C	120-126
20219653-17	2010	The inhibitory results suggested that the N4-reduction might be catalyzed by aldehyde oxidase in the cytosol of pigs, and by aldehyde oxidase and xanthine oxidase in the cytosol of rats.	Folic Acid	42-44	xanthine dehydrogenase	Sus scrofa	146-162
20031193-8	2010	CONCLUSIONS: These results show that SSAT plays an important role in novel folate cycle inhibitors effects and suggest that their combination with analogues has potential for development as therapy for ovarian carcinoma based on SSAT modulation.	Folic Acid	75-81	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	37-41
20412928-10	2010	The relative mRNA abundance of 5,10-methylene-tetrahydrofolate reductase and methylmalonyl-CoA mutase were increased by the combined injections of folic acid and vitamin B(12), whereas those of methionine synthase and methionine synthase reductase were not affected by treatments.	Folic Acid	147-157	5-methyltetrahydrofolate-homocysteine methyltransferase	Bos taurus	194-213
19839929-3	2010	Polyglutamate derivatives mainly inhibit three key enzymes of intracellular folate metabolism, i.e. thymidylates synthase (TYMS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), with TYMS being the most relevant target.	Folic Acid	76-82	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	Homo sapiens	166-210
19839929-3	2010	Polyglutamate derivatives mainly inhibit three key enzymes of intracellular folate metabolism, i.e. thymidylates synthase (TYMS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), with TYMS being the most relevant target.	Folic Acid	76-82	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	Homo sapiens	212-217
19764044-1	2009	Methylenetetrahydrofolate reductase (MTHFR) is important for folate and homocysteine (Hcy) metabolism.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Meleagris gallopavo	37-42
19764044-2	2009	MTHFR 677C-&gt;T and 1298A-&gt;C MTHFR are two most common mutations which can affect folate and total homocysteine (tHcy) status.	Folic Acid	86-92	methylenetetrahydrofolate reductase	Meleagris gallopavo	0-5
19764044-2	2009	MTHFR 677C-&gt;T and 1298A-&gt;C MTHFR are two most common mutations which can affect folate and total homocysteine (tHcy) status.	Folic Acid	86-92	methylenetetrahydrofolate reductase	Meleagris gallopavo	33-38
19764044-5	2009	The MTHFR 677C-&gt;T mutation-specific reference intervals for serum folate and tHcy were characterized by marked shifts in their upper limits.	Folic Acid	69-75	methylenetetrahydrofolate reductase	Meleagris gallopavo	4-9
23412981-2	2013	This study was designed to test the hypothesis that altered intake/metabolism of micronutrients (folic acid and vitamin B12) and docosahexaenoic acid (DHA) contributes to increased homocysteine and oxidative stress leading to altered levels of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in women delivering preterm.	Folic Acid	97-107	matrix metallopeptidase 2	Homo sapiens	271-275
23001810-8	2013	Low folate increased Ppara and Aldh1a1 expression, and decreased Bcmo1, Sprr2a, and Bmp5 expression in BALB/c, compared to BALB/c on control diets.	Folic Acid	4-10	aldehyde dehydrogenase family 1, subfamily A1	Mus musculus	31-38
23001810-8	2013	Low folate increased Ppara and Aldh1a1 expression, and decreased Bcmo1, Sprr2a, and Bmp5 expression in BALB/c, compared to BALB/c on control diets.	Folic Acid	4-10	beta-carotene oxygenase 1	Mus musculus	65-70
23001810-8	2013	Low folate increased Ppara and Aldh1a1 expression, and decreased Bcmo1, Sprr2a, and Bmp5 expression in BALB/c, compared to BALB/c on control diets.	Folic Acid	4-10	bone morphogenetic protein 5	Mus musculus	84-88
23267094-11	2013	In light of previous studies linking a common splice variant in the human MTHFD1L gene with increased risk for NTDs, this mouse model provides a powerful system to help elucidate the specific metabolic mechanisms that underlie folate-associated birth defects, including NTDs.	Folic Acid	227-233	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like	Homo sapiens	74-81
19764044-6	2009	In homozygote subjects for MTHFR 677C-&gt;T serum folate concentration was lower and serum tHcy concentration was higher than those in the wild genotype; all subjects had lower serum folate and 54% of the subjects had higher tHcy concentrations than the cutoff values of &lt;or=10 nmol/L and &gt;or=12 micromol/L, respectively.	Folic Acid	50-56	methylenetetrahydrofolate reductase	Meleagris gallopavo	27-32
19764044-6	2009	In homozygote subjects for MTHFR 677C-&gt;T serum folate concentration was lower and serum tHcy concentration was higher than those in the wild genotype; all subjects had lower serum folate and 54% of the subjects had higher tHcy concentrations than the cutoff values of &lt;or=10 nmol/L and &gt;or=12 micromol/L, respectively.	Folic Acid	183-189	methylenetetrahydrofolate reductase	Meleagris gallopavo	27-32
19764044-9	2009	These data show that the rate of MTHFR 677C-&gt;T and 1298A-&gt;C mutations is very high in Turks and serum folate and tHcy status are impaired by these mutations.	Folic Acid	108-114	methylenetetrahydrofolate reductase	Meleagris gallopavo	33-38
19767425-1	2009	GTP cyclohydrolase I (GCYH-I) is an essential Zn(2+)-dependent enzyme that catalyzes the first step of the de novo folate biosynthetic pathway in bacteria and plants, the 7-deazapurine biosynthetic pathway in Bacteria and Archaea, and the biopterin pathway in mammals.	Folic Acid	115-121	GTP cyclohydrolase 1	Homo sapiens	0-20
19615741-2	2009	In this communication, we describe the use of folate grafted PEI(600)-CyD (H(1)) as an effective polyplex-forming plasmid delivery agent with low toxicity.	Folic Acid	46-52	cytochrome b-245, beta polypeptide	Mus musculus	70-73
19615741-4	2009	We found that folate molecules were successfully grafted to PEI(600)-CyD.	Folic Acid	14-20	cytochrome b-245, beta polypeptide	Mus musculus	69-72
19650776-0	2009	The reduced folate carrier (SLC19A1) c.80G&gt;A polymorphism is associated with red cell folate concentrations among women.	Folic Acid	12-18	solute carrier family 19 member 1	Homo sapiens	28-35
19650776-0	2009	The reduced folate carrier (SLC19A1) c.80G&gt;A polymorphism is associated with red cell folate concentrations among women.	Folic Acid	89-95	solute carrier family 19 member 1	Homo sapiens	28-35
19650776-2	2009	As folate transport across cell membranes is mediated in part by the reduced folate carrier (RFC1), variants within SLC19A1, the gene that encodes RFC1, may influence disease risk via an effect on folate and/or homocysteine levels.	Folic Acid	3-9	solute carrier family 19 member 1	Homo sapiens	116-123
19650776-2	2009	As folate transport across cell membranes is mediated in part by the reduced folate carrier (RFC1), variants within SLC19A1, the gene that encodes RFC1, may influence disease risk via an effect on folate and/or homocysteine levels.	Folic Acid	77-83	solute carrier family 19 member 1	Homo sapiens	116-123
19451595-6	2009	Finally, we show that the folate-induced DNA methylation limits proliferation and increases the sensitivity to temozolomide-induced apoptosis in glioma cells through methylation of the genes implicated in these processes (PDGF-B, MGMT, survivin, and bcl-w).	Folic Acid	26-32	BCL2 like 2	Homo sapiens	250-255
19453682-2	2009	Population-wide folate status is expected to improve where folic acid fortification policies for reducing NTD occurrence are established.	Folic Acid	16-22	fuzzy planar cell polarity protein	Homo sapiens	106-109
19453682-2	2009	Population-wide folate status is expected to improve where folic acid fortification policies for reducing NTD occurrence are established.	Folic Acid	59-69	fuzzy planar cell polarity protein	Homo sapiens	106-109
19170661-4	2009	METHODS: In this study we estimated the flux of fatty acids (FA) through the stearoyl-CoA desaturase (SCD), phosphatidylethanolamine-N-methyltransferase (PEMT), and FA elongation pathways in relation to liver triacylglycerol (TG) content in Yucatan micropigs fed a 40% ethanol folate-deficient diet with or without supplementation with S-adenosyl methionine (SAM) compared with controls.	Folic Acid	277-283	phosphatidylethanolamine N-methyltransferase	Sus scrofa	154-158
19091803-10	2009	Co-incubation with folic acid blocked ethanol-induced teratogenesis, with up-regulated Hoxa1 and down-regulated miR-10a (P &lt; 0.01).	Folic Acid	19-29	homeobox A1	Mus musculus	87-92
19129954-1	2009	Methotrexate (MTX), an antagonist of folic acid, can inhibit dihydrofolate reductase (DHFR) which is of great importance in the synthesis of tetrahydrofolic acid and embryonic development.	Folic Acid	37-47	dihydrofolate reductase	Danio rerio	61-84
19129954-1	2009	Methotrexate (MTX), an antagonist of folic acid, can inhibit dihydrofolate reductase (DHFR) which is of great importance in the synthesis of tetrahydrofolic acid and embryonic development.	Folic Acid	37-47	dihydrofolate reductase	Danio rerio	86-90
19001075-6	2009	We found that PGA binds to and is internalized by J774.2 cells and accumulates in CD71 transferrin receptor-positive endosomes.	Folic Acid	14-17	transferrin receptor	Mus musculus	82-86
19064560-0	2008	Folate intake and risk of breast cancer by estrogen and progesterone receptor status in a Swedish cohort.	Folic Acid	0-6	progesterone receptor	Homo sapiens	56-77
19064560-3	2008	We examined the association between dietary folate intake and the risk of breast cancer by estrogen receptor (ER) and progesterone receptor (PR) status of the breast tumor in the Swedish Mammography Cohort.	Folic Acid	44-50	progesterone receptor	Homo sapiens	118-139
19064560-9	2008	However, folate intake was inversely associated with risk of ER+/PR- breast cancer (n = 417 cases; RR for highest versus lowest quintile, 0.79; 95% CI, 0.59-1.07; P(trend) = 0.01).	Folic Acid	9-15	progesterone receptor	Homo sapiens	65-67
18804286-1	2008	Periconceptional folic acid can reduce the occurrence of neural tube defects (NTDs) by up to 70%, and autoantibodies for folate receptors (FRs) have been observed in serum from women with a pregnancy complicated by an NTD.	Folic Acid	17-27	fuzzy planar cell polarity protein	Homo sapiens	78-81
18804286-2	2008	This population-based cohort study has examined serum from pregnant mothers for autoantibodies to FRs, antibodies to bovine folate binding protein (FBP), and inhibition of folic acid binding to FR and FBP in association with NTD risk.	Folic Acid	172-182	fuzzy planar cell polarity protein	Homo sapiens	225-228
18974876-2	2008	The first gene in the Plasmodium folate biosynthesis pathway, GTP-cyclohydrolase I (gch1), shows extensive CNP.	Folic Acid	33-39	GTP cyclohydrolase 1	Homo sapiens	62-82
18974876-2	2008	The first gene in the Plasmodium folate biosynthesis pathway, GTP-cyclohydrolase I (gch1), shows extensive CNP.	Folic Acid	33-39	GTP cyclohydrolase 1	Homo sapiens	84-88
18776693-3	2008	Since folate binding to placental brush-border membrane vesicles (BBMVs) was strongly inhibited by phosphatidylinositol-specific phospholipase C (PI-PLC) treatment, it is possible that FRalpha, a glycosyl phosphatidylinositol linked glycoprotein, is a candidate for folate uptake from maternal blood to the placenta.	Folic Acid	6-12	phospholipase C beta 1	Homo sapiens	99-144
18776693-3	2008	Since folate binding to placental brush-border membrane vesicles (BBMVs) was strongly inhibited by phosphatidylinositol-specific phospholipase C (PI-PLC) treatment, it is possible that FRalpha, a glycosyl phosphatidylinositol linked glycoprotein, is a candidate for folate uptake from maternal blood to the placenta.	Folic Acid	6-12	phospholipase C beta 1	Homo sapiens	146-152
18776693-3	2008	Since folate binding to placental brush-border membrane vesicles (BBMVs) was strongly inhibited by phosphatidylinositol-specific phospholipase C (PI-PLC) treatment, it is possible that FRalpha, a glycosyl phosphatidylinositol linked glycoprotein, is a candidate for folate uptake from maternal blood to the placenta.	Folic Acid	266-272	phospholipase C beta 1	Homo sapiens	146-152
18776693-4	2008	Moreover, additional inhibitory effects of thiamine pyrophosphate (TPP) and hemin on folate uptake after PI-PLC treatment suggested that not only FRalpha but also RFC and heme carrier protein 1 (HCP1) are involved in the folate transport mechanism in the human placenta.	Folic Acid	221-227	phospholipase C beta 1	Homo sapiens	105-111
18597513-3	2008	Folate differentially altered activity and expression of proteins involved in proliferation [e.g., PCNA], DNA repair [e.g., XRCC5, MSH2], apoptosis [e.g., BAG family chaperone protein, DIABLO and porin], cytoskeletal organization [e.g., actin, ezrin, elfin], and expression of proteins implicated in malignant transformation [COMT, Nit2].	Folic Acid	0-6	X-ray repair cross complementing 5	Homo sapiens	124-129
18597513-3	2008	Folate differentially altered activity and expression of proteins involved in proliferation [e.g., PCNA], DNA repair [e.g., XRCC5, MSH2], apoptosis [e.g., BAG family chaperone protein, DIABLO and porin], cytoskeletal organization [e.g., actin, ezrin, elfin], and expression of proteins implicated in malignant transformation [COMT, Nit2].	Folic Acid	0-6	mutS homolog 2	Homo sapiens	131-135
18597513-3	2008	Folate differentially altered activity and expression of proteins involved in proliferation [e.g., PCNA], DNA repair [e.g., XRCC5, MSH2], apoptosis [e.g., BAG family chaperone protein, DIABLO and porin], cytoskeletal organization [e.g., actin, ezrin, elfin], and expression of proteins implicated in malignant transformation [COMT, Nit2].	Folic Acid	0-6	voltage dependent anion channel 1	Homo sapiens	196-201
18597513-3	2008	Folate differentially altered activity and expression of proteins involved in proliferation [e.g., PCNA], DNA repair [e.g., XRCC5, MSH2], apoptosis [e.g., BAG family chaperone protein, DIABLO and porin], cytoskeletal organization [e.g., actin, ezrin, elfin], and expression of proteins implicated in malignant transformation [COMT, Nit2].	Folic Acid	0-6	PDZ and LIM domain 1	Homo sapiens	251-256
18597513-3	2008	Folate differentially altered activity and expression of proteins involved in proliferation [e.g., PCNA], DNA repair [e.g., XRCC5, MSH2], apoptosis [e.g., BAG family chaperone protein, DIABLO and porin], cytoskeletal organization [e.g., actin, ezrin, elfin], and expression of proteins implicated in malignant transformation [COMT, Nit2].	Folic Acid	0-6	catechol-O-methyltransferase	Homo sapiens	326-330
18480750-0	2008	Angiopoietin-1 therapy enhances fibrosis and inflammation following folic acid-induced acute renal injury.	Folic Acid	68-78	angiopoietin 1	Homo sapiens	0-14
18480750-4	2008	We tested here the effect of angiopoietin-1 treatment on capillary loss and associated tubulointerstitial damage known to follow recovery from folic acid-induced tubular necrosis and acute renal injury.	Folic Acid	143-153	angiopoietin 1	Homo sapiens	29-43
18480750-5	2008	We found that delivery of angiopoietin-1 by adenoviral vectors stabilized peritubular capillaries in folic acid nephropathy but this was accompanied by profibrotic and inflammatory effects.	Folic Acid	101-111	angiopoietin 1	Homo sapiens	26-40
18626492-3	2008	However, angiopoietin-1 therapy in the setting of folate-induced acute kidney injury resulted in an expanded fibrotic response despite apparent preservation of the vasculature, indicating that renal repair responses are complex and vascular-directed therapies should be approached with caution.	Folic Acid	50-56	angiopoietin 1	Homo sapiens	9-23
18614692-4	2008	Folate depletion increased nuclear mutation rates in Ung-/- embryonic fibroblasts, and conferred death of cultured Ung-/- hippocampal neurons.	Folic Acid	0-6	uracil DNA glycosylase	Mus musculus	53-56
18614692-4	2008	Folate depletion increased nuclear mutation rates in Ung-/- embryonic fibroblasts, and conferred death of cultured Ung-/- hippocampal neurons.	Folic Acid	0-6	uracil DNA glycosylase	Mus musculus	115-118
18614692-5	2008	Feeding animals a folate-deficient diet (FD) for 3 months induced degeneration of CA3 pyramidal neurons in Ung-/- but not Ung+/+ mice along with decreased hippocampal expression of brain-derived neurotrophic factor protein and decreased brain levels of antioxidant glutathione.	Folic Acid	18-24	uracil DNA glycosylase	Mus musculus	107-110
18413293-2	2008	Methionine synthase reductase (MTRR) is required for activation of methionine synthase, a folate- and vitamin B(12)-dependent enzyme.	Folic Acid	90-96	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Mus musculus	0-29
18413293-2	2008	Methionine synthase reductase (MTRR) is required for activation of methionine synthase, a folate- and vitamin B(12)-dependent enzyme.	Folic Acid	90-96	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Mus musculus	31-35
18598588-6	2008	In contrast, in North America and Chile, the policy of mandatory folic acid-fortification has proven itself in terms of lowering the prevalence of NTD, but remains controversial because of concerns regarding potential risks of chronic exposure to high-dose folic acid.	Folic Acid	65-75	fuzzy planar cell polarity protein	Homo sapiens	147-150
18174275-1	2008	Proton-coupled folate transporter/heme carrier protein 1 (PCFT/HCP1) has recently been identified as a transporter that mediates the translocation of folates across the cellular membrane by a proton-coupled mechanism and suggested to be the possible molecular entity of the carrier-mediated intestinal folate transport system.	Folic Acid	150-157	solute carrier family 46 member 1	Rattus norvegicus	0-56
18174275-1	2008	Proton-coupled folate transporter/heme carrier protein 1 (PCFT/HCP1) has recently been identified as a transporter that mediates the translocation of folates across the cellular membrane by a proton-coupled mechanism and suggested to be the possible molecular entity of the carrier-mediated intestinal folate transport system.	Folic Acid	150-157	solute carrier family 46 member 1	Rattus norvegicus	58-67
18174275-1	2008	Proton-coupled folate transporter/heme carrier protein 1 (PCFT/HCP1) has recently been identified as a transporter that mediates the translocation of folates across the cellular membrane by a proton-coupled mechanism and suggested to be the possible molecular entity of the carrier-mediated intestinal folate transport system.	Folic Acid	15-21	solute carrier family 46 member 1	Rattus norvegicus	58-67
18174275-3	2008	rPCFT/HCP1 was demonstrated to transport folate and methotrexate more efficiently at lower acidic pH and, as evaluated at pH 5.5, with smaller Michaelis constant (K(m)) for the former (2.4 microM) than for the latter (5.7 microM), indicating its characteristic as a proton-coupled folate transporter that favors folate than methotrexate as substrate.	Folic Acid	41-47	solute carrier family 46 member 1	Rattus norvegicus	0-10
18174275-3	2008	rPCFT/HCP1 was demonstrated to transport folate and methotrexate more efficiently at lower acidic pH and, as evaluated at pH 5.5, with smaller Michaelis constant (K(m)) for the former (2.4 microM) than for the latter (5.7 microM), indicating its characteristic as a proton-coupled folate transporter that favors folate than methotrexate as substrate.	Folic Acid	281-287	solute carrier family 46 member 1	Rattus norvegicus	0-10
18174275-5	2008	All these characteristics of rPCFT/HCP1 were in agreement with those of carrier-mediated intestinal folate transport system, of which the K(m) values were 1.2 and 5.8 microM for folate and methotrexate, respectively, in the rat small intestine.	Folic Acid	100-106	solute carrier family 46 member 1	Rattus norvegicus	29-39
18174275-5	2008	All these characteristics of rPCFT/HCP1 were in agreement with those of carrier-mediated intestinal folate transport system, of which the K(m) values were 1.2 and 5.8 microM for folate and methotrexate, respectively, in the rat small intestine.	Folic Acid	178-184	solute carrier family 46 member 1	Rattus norvegicus	29-39
18056255-1	2008	Dihydrofolate reductase (DHFR) catalyzes folic acid reduction and recycles dihydrofolate generated during dTMP biosynthesis to tetrahydrofolate.	Folic Acid	41-51	dihydrofolate reductase	Danio rerio	0-23
18056255-1	2008	Dihydrofolate reductase (DHFR) catalyzes folic acid reduction and recycles dihydrofolate generated during dTMP biosynthesis to tetrahydrofolate.	Folic Acid	41-51	dihydrofolate reductase	Danio rerio	25-29
18056255-9	2008	In addition, the DHFR-mediated dihydrofolate reduction was significantly inhibited by its own substrate folic acid.	Folic Acid	104-114	dihydrofolate reductase	Danio rerio	17-21
18269770-6	2008	GFP-FLN localized to the peripheral cell cortex as well as to new pseudopods of unpolarized cells, but was observed to localize to the rear of polarized cells during cAMP and folate chemotaxis.	Folic Acid	175-181	filamin C	Homo sapiens	4-7
18850227-2	2008	We examined whether folate deficiency affects platelet endothelial cell adhesion molecule-1 (PECAM-1), which is an immunoglobulin-associated cell adhesion molecule and mediates the final common pathway of neutrophil transendothelial migration, in blood vessels in the gerbil dentate gyrus after transient forebrain ischemia.	Folic Acid	20-26	platelet and endothelial cell adhesion molecule 1	Homo sapiens	93-100
18850227-8	2008	Our results suggest that folate deficiency enhances PECAM-1 in the dentate gyrus induced by transient ischemia.	Folic Acid	25-31	platelet and endothelial cell adhesion molecule 1	Homo sapiens	52-59
18078840-12	2008	From the clinical point of view, the folate sensitive rare fragile site FRAXA is the most important fragile site as it is associated with the fragile X syndrome, the most common form of familial mental retardation, affecting about 1/4000 males and 1/6000 females.	Folic Acid	37-43	fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)	Homo sapiens	72-77
17928088-10	2007	Selective binding and uptake of folate-targeted lipodots by J6456-FR cells was also observed in vivo after intra-peritoneal injection in mice bearing ascitic J6456-FR tumors based on FACS analysis and confocal imaging of harvested cells from the peritoneal cavity.	Folic Acid	32-38	acyl-CoA synthetase long-chain family member 1	Mus musculus	183-187
18030639-2	2007	Consuming the B vitamin folic acid can reduce the incidence of NTDs 50%-70%, and recent efforts to reduce NTD rates have focused on increasing the number of childbearing-aged women who take a vitamin containing folic acid every day.	Folic Acid	24-34	fuzzy planar cell polarity protein	Homo sapiens	63-66
17475669-1	2007	Two putative orthologs to the human reduced folate carrier (hRFC), folt-1 and folt-2, which share a 40 and 31% identity, respectively, with the hRFC sequence, have been identified in the Caenorhabditis elegans genome.	Folic Acid	44-50	solute carrier family 19 member 1	Homo sapiens	60-64
17475669-1	2007	Two putative orthologs to the human reduced folate carrier (hRFC), folt-1 and folt-2, which share a 40 and 31% identity, respectively, with the hRFC sequence, have been identified in the Caenorhabditis elegans genome.	Folic Acid	44-50	Folate-like transporter 2	Caenorhabditis elegans	78-84
17475669-1	2007	Two putative orthologs to the human reduced folate carrier (hRFC), folt-1 and folt-2, which share a 40 and 31% identity, respectively, with the hRFC sequence, have been identified in the Caenorhabditis elegans genome.	Folic Acid	44-50	solute carrier family 19 member 1	Homo sapiens	144-148
22894559-2	2012	It is a multitargeted antifolate that gets transported to cells primarily by reduced folate carrier (RFC) and exerts its action by disrupting folate-dependent metabolic processes essential for cell replication.	Folic Acid	26-32	solute carrier family 19 member 1	Homo sapiens	77-99
22894559-2	2012	It is a multitargeted antifolate that gets transported to cells primarily by reduced folate carrier (RFC) and exerts its action by disrupting folate-dependent metabolic processes essential for cell replication.	Folic Acid	26-32	solute carrier family 19 member 1	Homo sapiens	101-104
22714056-1	2012	A polypyrrolic macrocycle with naphthalenyl linkers between the N(4)-donor compartments (L(2)) was designed theoretically according to its experimentally-known analogues with phenylenyl (L(1)) and anthracenyl (L(3)) linkers.	Folic Acid	64-68	immunoglobulin kappa variable 3-15	Homo sapiens	89-93
22964462-10	2012	CONCLUSIONS: A positive correlation exists between oxidative stress produced by T2DM and DNA damage, so the use of an antioxidant such as folic acid in DM2 therapy is advisable for delaying complications due to T2DM-induced oxidative stress and DNA damage.	Folic Acid	138-148	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	152-155
22484375-6	2012	The elevate expression of dihydrofolate reductase and thymidylate synthase, two E2F1-target genes involved in folate metabolism and required for G(1) progression, favored dTTP accumulation, which promoted DNA single strand breaks and the subsequent activation of Chk1.	Folic Acid	33-39	ttp	Drosophila melanogaster	171-175
22085872-2	2012	We addressed the question of whether folic acid (FA) supplementation can affect serum alanine aminotransferase (ALT) level in hypertensive Chinese adults.	Folic Acid	37-47	glutamic--pyruvic transaminase	Homo sapiens	86-110
22566245-4	2012	Data generated indicated that folic acid and vitamin B12 separately or in combination can give significant protection against alterations in oxidative stress and apoptotic marker parameters and downstream changes in mitochondria, namely pro-oxidative (NO, TBARS, OH-) and antioxidative defense (SOD, CAT, GSH) markers, iNOS protein expression, mitochondrial swelling, cytochrome c oxidase and Ca2+-ATPase activity, Ca2+ content, caspase-3 activity.	Folic Acid	30-40	caspase 3	Rattus norvegicus	429-438
22037925-0	2012	Involvement of PI3K, GSK-3beta and PPARgamma in the antidepressant-like effect of folic acid in the forced swimming test in mice.	Folic Acid	82-92	peroxisome proliferator activated receptor gamma	Mus musculus	35-44
22037925-4	2012	pre-treatment of mice with LY294002 (10 nmol/site, a PI3K inhibitor) or GW-9662 (1 microg/site, a PPARgamma antagonist) prevented the antidepressant-like effect of folic acid (50 mg/kg, p.o.)	Folic Acid	164-174	peroxisome proliferator activated receptor gamma	Mus musculus	98-107
22037925-10	2012	These results indicate that the antidepressant-like effect of folic acid in the FST might be dependent on inhibition of GSK-3beta and activation of PPARgamma, reinforcing the notion that these are important targets for antidepressant activity.	Folic Acid	62-72	peroxisome proliferator activated receptor gamma	Mus musculus	148-157
22101525-4	2012	To test the hypothesis that an imbalance in MMP-to-TIMP ratio leads to interstitial fibrosis and RVF and whether the treatment with folic acid (FA) alleviates ROS generation, maintains MMP/TIMP balance, and regresses interstitial fibrosis, we used a mouse model of pulmonary artery constriction (PAC).	Folic Acid	132-142	matrix metallopeptidase 13	Mus musculus	185-188
22061491-5	2012	In particular, animal studies using the in situ rat C6 glioma model showed that the folate-targeted co-delivery of BCL-2 siRNA and DOX caused not only an obvious down-regulation of the anti-apoptotic BCL-2 gene but also a remarkable up-regulation of the pro-apoptotic Bax gene, resulting in the significantly elevated level of caspase-3 activation and remarkable cell apoptosis in tumor tissues.	Folic Acid	84-90	caspase 3	Rattus norvegicus	327-336
20359777-4	2012	The levels of TFPI and Hcy were positively correlated in hyperhomocysteinemic AD and mild cognitive impairment subjects, and were negatively correlated with folate levels.	Folic Acid	157-163	tissue factor pathway inhibitor	Homo sapiens	14-18
20359777-6	2012	Therefore, TFPI may represent a candidate marker of endothelial damage in AD and might be used for the identification and monitoring of patients that would benefit from folate supplementation treatment.	Folic Acid	169-175	tissue factor pathway inhibitor	Homo sapiens	11-15
21976482-10	2011	We hypothesize that yet unknown kinetic properties of SHM2 might render this enzyme unsuitable for the high-folate conditions of photorespiring mesophyll mitochondria.	Folic Acid	108-114	serine hydroxymethyltransferase 2	Arabidopsis thaliana	54-58
21956977-2	2011	Recurrence of NTDs despite supplementation of high dose of folic acid further suggests that a proportion of NTD cases might be resistant to folic acid.	Folic Acid	140-150	fuzzy planar cell polarity protein	Homo sapiens	14-17
23190757-0	2013	Reduced MTHFD1 activity in male mice perturbs folate- and choline-dependent one-carbon metabolism as well as transsulfuration.	Folic Acid	46-52	methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase	Mus musculus	8-14
23190757-2	2013	These pathways have been shown to be sensitive to variation within the Mthfd1 gene, which codes for a folate-metabolizing enzyme responsible for generating 1-carbon (1-C)-substituted folate derivatives.	Folic Acid	102-108	methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase	Mus musculus	71-77
23190757-2	2013	These pathways have been shown to be sensitive to variation within the Mthfd1 gene, which codes for a folate-metabolizing enzyme responsible for generating 1-carbon (1-C)-substituted folate derivatives.	Folic Acid	183-189	methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase	Mus musculus	71-77
23190757-9	2013	The metabolic alterations observed in Mthfd1(gt/+) mice indicate perturbed choline and folate-dependent 1-C metabolism and support the future use of Mthfd1(gt/+) mice as a tool to investigate the impact of impaired 1-C metabolism on disease outcomes.	Folic Acid	87-93	methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase	Mus musculus	38-44
23859041-5	2013	DUSP genes interacted with carbohydrates, mutagen index, calories, calcium, vitamin D, lycopene, dietary fats, folic acid, and selenium.	Folic Acid	111-121	dual specificity phosphatase 5	Homo sapiens	0-4
22554803-1	2012	5-Aminoimidazole-4-carboxamide riboside (AICAR), an agent with diverse pharmacological properties, augments transport of folates and antifolates.	Folic Acid	121-128	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	41-46
22554803-3	2012	Exposure of HeLa cells to AICAR resulted in augmentation of methotrexate, 5-formyltetrahydrofolate, and 5-methyltetrahydrofolate initial rates and net uptake in cells that express the reduced folate carrier (RFC).	Folic Acid	92-98	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	26-31
22554803-6	2012	When ZMP formation was blocked with 5-iodotubercidin, an inhibitor of adenosine kinase, folate transport stimulation by AICAR was absent.	Folic Acid	88-94	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	120-125
22554803-7	2012	When cells first accumulated ZMP and were then exposed to 5-iodotubercidin or AICAR-free buffer, the ZMP level markedly decreased and folate transport stimulation was abolished.	Folic Acid	134-140	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	78-83
22838948-1	2012	AIM: The rationale of this study was to explore the contribution of genetic variants of the folate pathway to toxicity of 6-mercaptopurine (6-MP)-mediated hematological toxicity in children with acute lymphoblastic leukemia (ALL) and to explore the interaction of these variants with TPMT and ITPA haplotypes using multifactor dimensionality reduction analysis.	Folic Acid	92-98	thiopurine S-methyltransferase	Homo sapiens	284-288
23248680-3	2012	The present study attempted to look into the association of occurrence of NTD with reference to folic acid levels, along with karyotyping status.	Folic Acid	96-106	fuzzy planar cell polarity protein	Homo sapiens	74-77
23248680-11	2012	CONCLUSION: Folic acid supplementation needs to be continued to prevent the occurrence of NTD, and the perinatal identification of NTD should alert one to the possibility of chromosomal abnormalities and prompt a thorough cytogenetic investigation and genetic counseling.	Folic Acid	12-22	fuzzy planar cell polarity protein	Homo sapiens	90-93
22180326-8	2012	MMP-2 and MMP-9 activities were increased in embryos and decidua from diabetic rats and decreased with safflower oil and folic acid supplementations.	Folic Acid	121-131	matrix metallopeptidase 2	Rattus norvegicus	0-5
21939673-3	2012	Zn is an essential cofactor or structural component for important antioxidant defence proteins and DNA repair enzymes such as Cu/Zn SOD, OGG1, APE and PARP and may also affect activities of enzymes such as BHMT and MTR involved in methylation reactions in the folate-methionine cycle.	Folic Acid	260-266	betaine--homocysteine S-methyltransferase	Homo sapiens	206-210
22480165-6	2012	To perturb folate metabolism we exposed zebrafish embryos to methotrexate (MTX), a potent inhibitor of dihydrofolate reductase (Dhfr) an essential enzyme in the folate metabolic pathway.	Folic Acid	11-17	dihydrofolate reductase	Danio rerio	128-132
22434686-1	2012	Methotrexate and aminopterin are folic acid antagonists that inhibit dihydrofolate reductase, resulting in a block in the synthesis of thymidine and inhibition of DNA synthesis.	Folic Acid	33-43	dihydrofolate reductase	Oryctolagus cuniculus	69-92
22370993-1	2012	Folate has been implicated in cardiovascular disease with atypical antipsychotic (AAPs) use, and individuals with methylenetetrahydrofolate reductase (MTHFR) and catechol-O-methyl transferase (COMT) variants are at greater risk.	Folic Acid	0-6	catechol-O-methyltransferase	Homo sapiens	193-197
22147198-2	2012	The steady-state accumulation of folate seems to depend on the activity of two enzymes: folylpolyglutamate synthetase (FPGS), which adds glutamate residues, and gamma-glutamyl hydrolase (GGH), which removes them, enabling it to be transported across the biological membranes.	Folic Acid	33-39	gamma-glutamyl hydrolase	Rattus norvegicus	161-185
22147198-2	2012	The steady-state accumulation of folate seems to depend on the activity of two enzymes: folylpolyglutamate synthetase (FPGS), which adds glutamate residues, and gamma-glutamyl hydrolase (GGH), which removes them, enabling it to be transported across the biological membranes.	Folic Acid	33-39	gamma-glutamyl hydrolase	Rattus norvegicus	187-190
23227377-3	2012	Considering the high prevalence of iron, folic-acid, and vitamin B(12) deficiencies in developing countries, their coexistence with MPN can be expected frequently.	Folic Acid	41-51	serine protease 27	Homo sapiens	132-135
22113051-2	2011	Dihydrofolate reductase (DHFR) is a key enzyme in folate-mediated metabolism.	Folic Acid	7-13	dihydrofolate reductase	Danio rerio	25-29
22113051-3	2011	The dysfunction of DHFR disrupts the key biological processes which folic acid participates in.	Folic Acid	68-78	dihydrofolate reductase	Danio rerio	19-23
22065534-2	2011	The folate-sensitive fragile site FRAXE is located in Xq28 approximately 600 kb distal to the fragile X syndrome fragile site (FRAXA) and harbors an unstable GCC (CCG) triplet repeat adjacent to a CpG island in the 5" untranslated region of the AFF2 (FMR2) gene.	Folic Acid	4-10	fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)	Homo sapiens	127-132
21640799-11	2011	In conclusion, the results of this study show that folic acid can protect against dexamethasone-induced neurotoxicity and its protective mechanism is related to a signaling pathway that involves PI3K/Akt, CaMKII, and PKA.	Folic Acid	51-61	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	205-211
21736840-1	2011	Few studies have evaluated the relationship between the consumption of dietary folate and one-carbon metabolism-related nutrients and breast cancer risk defined by oestrogen receptor (ER) and progesterone receptor (PR) status.	Folic Acid	79-85	progesterone receptor	Homo sapiens	192-213
21736840-1	2011	Few studies have evaluated the relationship between the consumption of dietary folate and one-carbon metabolism-related nutrients and breast cancer risk defined by oestrogen receptor (ER) and progesterone receptor (PR) status.	Folic Acid	79-85	progesterone receptor	Homo sapiens	215-217
21736840-9	2011	A significant inverse association between dietary folate intake and breast cancer risk was observed in all subtypes of ER and PR status.	Folic Acid	50-56	progesterone receptor	Homo sapiens	126-128
21739597-1	2011	The fragile X syndrome, fragile X tremor ataxia syndrome, and premature ovarian insufficiency are conditions related to the X chromosome folate-sensitive fragile site FRAXA.	Folic Acid	137-143	fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)	Homo sapiens	167-172
21375537-2	2011	Cyclic voltammetry showed an irreversible two-electron anodic process for folate, E = 1.14 V versus NHE at a scan-rate of 50 mV s(-1), which appears to be kinetically controlled by the heterogeneous electron transfer from the substrates to the electrode.	Folic Acid	74-80	solute carrier family 9 member C1	Homo sapiens	100-103
21427733-6	2011	Among premenopausal women, increased risk associated with the SMUG1 rs2029166 genotype was limited to those with low folate intake.	Folic Acid	117-123	single-strand-selective monofunctional uracil-DNA glycosylase 1	Homo sapiens	62-67
21441543-8	2011	CONCLUSIONS: Red cell folate concentrations in women not complying with recommendations were suboptimal in relation to NTD risk.	Folic Acid	22-28	fuzzy planar cell polarity protein	Homo sapiens	119-122
21481001-11	2011	Apoptosis and TGFbeta signaling in MEPM cells were involved in folic acid rescued ATRA-induced cleft palate.	Folic Acid	63-73	transforming growth factor, beta 1	Mus musculus	14-21
21542559-17	2004	One of the NIR dyes (NIR2) was conjugated to amino-derivatized folic acid to form NIR2-folate, which has an excitation maximum at 665 nm and an emission maximum at 686 nm.	Folic Acid	63-73	phosphatidylinositol transfer protein membrane associated 1	Homo sapiens	21-25
21542559-17	2004	One of the NIR dyes (NIR2) was conjugated to amino-derivatized folic acid to form NIR2-folate, which has an excitation maximum at 665 nm and an emission maximum at 686 nm.	Folic Acid	63-73	phosphatidylinositol transfer protein membrane associated 1	Homo sapiens	82-86
21324323-1	2011	AIMS: Folate coenzymes and dependent enzymes introduce one carbon units at positions 2 (C(2)) and 8 (C(8)) of the purine ring during de novo biosynthesis.	Folic Acid	6-12	homeobox C8	Homo sapiens	101-105
21092376-9	2011	The decrease in folate uptake was also associated with the down-regulation in the protein levels of major folate transporters, proton-coupled folate transporter (PCFT) and reduced folate carrier (RFC), without altering their mRNA levels.	Folic Acid	16-22	solute carrier family 46 member 1	Rattus norvegicus	127-160
21092376-9	2011	The decrease in folate uptake was also associated with the down-regulation in the protein levels of major folate transporters, proton-coupled folate transporter (PCFT) and reduced folate carrier (RFC), without altering their mRNA levels.	Folic Acid	16-22	solute carrier family 46 member 1	Rattus norvegicus	162-166
21092376-10	2011	Hence, it was concluded that acute folate oversupplementation results in a significant decrease in intestinal folate uptake by down-regulating the expressions of RFC and PCFT, via some post-transcriptional or translational mechanisms.	Folic Acid	35-41	solute carrier family 46 member 1	Rattus norvegicus	170-174
21092376-10	2011	Hence, it was concluded that acute folate oversupplementation results in a significant decrease in intestinal folate uptake by down-regulating the expressions of RFC and PCFT, via some post-transcriptional or translational mechanisms.	Folic Acid	110-116	solute carrier family 46 member 1	Rattus norvegicus	170-174
21069807-5	2011	The decreased transport activity at the CAM was associated with down-regulation of the proton-coupled folate transporter (PCFT) and the reduced folate carrier (RFC) which resulted in decreased PCFT and RFC protein levels in the colon of rats fed alcohol chronically.	Folic Acid	102-108	solute carrier family 46 member 1	Rattus norvegicus	122-126
21069807-5	2011	The decreased transport activity at the CAM was associated with down-regulation of the proton-coupled folate transporter (PCFT) and the reduced folate carrier (RFC) which resulted in decreased PCFT and RFC protein levels in the colon of rats fed alcohol chronically.	Folic Acid	102-108	solute carrier family 46 member 1	Rattus norvegicus	193-197
21069807-9	2011	Hence, we propose that downregulation in the expression of the PCFT and the RFC in colon results in reduced levels of these transporters in colon apical membrane LR as a mechanism of folate malabsorption during chronic alcoholism.	Folic Acid	183-189	solute carrier family 46 member 1	Rattus norvegicus	63-67
21157027-8	2011	Together, these results show the antioxidant effect of the combination of folic acid and alpha-tocopherol, as observed by the decrease in NO generation from iNOS and nNOS, preventing an increase in the activity of mitochondrial complexes, mainly I and IV, and the neuronal death induced by the Abeta1-40 peptide.	Folic Acid	74-84	nitric oxide synthase 1, neuronal	Mus musculus	166-170
21109973-6	2011	Using methylation-specific PCR, p73 was shown to be more frequently methylated in the high folate group [50% (8 of 16)] than in the medium [16.7% (3 of 18)] or low folate subgroups [11.1% (2 of 18)].	Folic Acid	91-97	tumor protein p73	Homo sapiens	32-35
21109973-6	2011	Using methylation-specific PCR, p73 was shown to be more frequently methylated in the high folate group [50% (8 of 16)] than in the medium [16.7% (3 of 18)] or low folate subgroups [11.1% (2 of 18)].	Folic Acid	164-170	tumor protein p73	Homo sapiens	32-35
21109973-7	2011	In conclusion, subjects with the variant MTHFR 677TT genotype appeared to have a significantly lower risk for colorectal cancer than those with the MTHFR 677CC genotype, and the methylation status of circulating p73 genomic DNA was substantially altered by the plasma folate level.	Folic Acid	268-274	tumor protein p73	Homo sapiens	212-215
22140583-1	2011	Despite compelling epidemiological evidence that folic acid supplements reduce the frequency of neural tube defects (NTDs) in newborns, common variant association studies with folate metabolism genes have failed to explain the majority of NTD risk.	Folic Acid	49-59	fuzzy planar cell polarity protein	Homo sapiens	117-120
22039442-9	2011	We identified a novel association with SLC19A1, which is important for transport of folate into cells.	Folic Acid	84-90	solute carrier family 19 member 1	Homo sapiens	39-46
20130891-6	2010	In vitro folate bioaccessibility was assessed using the TNO gastrointestinal model TIM.	Folic Acid	9-15	Rho guanine nucleotide exchange factor 5	Homo sapiens	83-86
17637246-1	2007	BACKGROUND: Folic acid is very important for embryonic development and dihydrofolate reductase is one of the key enzymes in the process of folic acid performing its biological function.	Folic Acid	12-22	dihydrofolate reductase	Danio rerio	71-94
17637246-1	2007	BACKGROUND: Folic acid is very important for embryonic development and dihydrofolate reductase is one of the key enzymes in the process of folic acid performing its biological function.	Folic Acid	139-149	dihydrofolate reductase	Danio rerio	71-94
17637246-2	2007	Therefore, the dysfunction of dihydrofolate reductase can inhibit the function of folic acid and finally cause the developmental malformations.	Folic Acid	82-92	dihydrofolate reductase	Danio rerio	30-53
17389618-7	2007	We observed significant evidence for departure from multiplicative interaction for the betaine-homocysteine methyltransferase (BHMT) Arg239Gln with dietary methyl status (based on intake of dietary folate, methionine and alcohol intake) in relation to colorectal adenoma; no such interaction was observed for the other 23 SNPs.	Folic Acid	198-204	betaine--homocysteine S-methyltransferase	Homo sapiens	87-125
17389618-7	2007	We observed significant evidence for departure from multiplicative interaction for the betaine-homocysteine methyltransferase (BHMT) Arg239Gln with dietary methyl status (based on intake of dietary folate, methionine and alcohol intake) in relation to colorectal adenoma; no such interaction was observed for the other 23 SNPs.	Folic Acid	198-204	betaine--homocysteine S-methyltransferase	Homo sapiens	127-131
17533620-5	2007	Consistent with this, FIG selection also retrieved: the PMA1 gene, encoding the plasma H(+)-membrane ATPase; FOL2 and FOL3, involved in folic acid biosynthesis; and UBR2, which indirectly downregulates the proteasome genes.	Folic Acid	136-146	H(+)-exporting P2-type ATPase PMA1	Saccharomyces cerevisiae S288C	56-60
17533620-5	2007	Consistent with this, FIG selection also retrieved: the PMA1 gene, encoding the plasma H(+)-membrane ATPase; FOL2 and FOL3, involved in folic acid biosynthesis; and UBR2, which indirectly downregulates the proteasome genes.	Folic Acid	136-146	GTP cyclohydrolase I	Saccharomyces cerevisiae S288C	109-113
17482559-1	2007	The sodium dependent reduced folate carrier (Rfc1; Slc19a1) provides the major route for cellular uptake of reduced folates and antifolate drugs such as methotrexate (MTX) into various tissues.	Folic Acid	116-123	solute carrier family 19 member 1	Rattus norvegicus	51-58
17334909-1	2007	This review attempts to provide a comprehensive overview of the biology of the physiologically and pharmacologically important transport system termed the "reduced folate carrier" (RFC).	Folic Acid	164-170	solute carrier family 19 member 1	Homo sapiens	181-184
17334909-2	2007	The ubiquitously expressed RFC has unequivocally established itself as the major transport system in mammalian cells and tissues for a group of compounds including folate cofactors and classical antifolate therapeutics.	Folic Acid	164-170	solute carrier family 19 member 1	Homo sapiens	27-30
17264883-3	2007	Many genetic factors play a role in folate-homocysteine metabolism, like functional polymorphism (Val108Met) in the Catechol-O-methyltransferase (COMT) gene.	Folic Acid	36-42	catechol-O-methyltransferase	Homo sapiens	116-144
17264883-3	2007	Many genetic factors play a role in folate-homocysteine metabolism, like functional polymorphism (Val108Met) in the Catechol-O-methyltransferase (COMT) gene.	Folic Acid	36-42	catechol-O-methyltransferase	Homo sapiens	146-150
17565222-0	2007	The influence of levodopa and the COMT inhibitor on serum vitamin B12 and folate levels in Parkinson"s disease patients.	Folic Acid	74-80	catechol-O-methyltransferase	Homo sapiens	34-38
17079455-8	2006	An immunofluorescence assay for CDC25c activity (phosphorylated CDC2) also found CDC25c activity to be decreased in folate-deficient normal intestine.	Folic Acid	116-122	cell division cycle 25C	Mus musculus	32-38
17079455-8	2006	An immunofluorescence assay for CDC25c activity (phosphorylated CDC2) also found CDC25c activity to be decreased in folate-deficient normal intestine.	Folic Acid	116-122	cyclin-dependent kinase 1	Mus musculus	32-36
17079455-8	2006	An immunofluorescence assay for CDC25c activity (phosphorylated CDC2) also found CDC25c activity to be decreased in folate-deficient normal intestine.	Folic Acid	116-122	cell division cycle 25C	Mus musculus	81-87
17079455-10	2006	Our data suggest that folate deficiency can initiate tumor development, that Mthfr mutation can enhance this phenomenon, and that altered expression of Plk1 and Cdc25c may contribute to folate-dependent intestinal tumorigenesis.	Folic Acid	186-192	cell division cycle 25C	Mus musculus	161-167
17035141-5	2006	RESULTS: Only single nucleotide polymorphisms (SNPs) in BHMT were significantly associated in the overall data set; this significance was strongest when mothers took folate-containing nutritional supplements before conception.	Folic Acid	166-172	betaine--homocysteine S-methyltransferase	Homo sapiens	56-60
16815871-14	2006	Thalidomide and PGA also significantly inhibited P-glycoprotein (PgP/MDR1), multidrug resistance-associated protein (MRP1)- and MRP2-mediated CPT-11 and SN-38 transport in MDCKII cells.	Folic Acid	16-19	ATP binding cassette subfamily B member 1	Canis lupus familiaris	69-73
16332725-8	2006	The impact of ALDH2 Lys+ with ADH2 Arg+ was more evident in low folate consumer (OR = 2.32, 1.19-4.55) than high folate consumer (OR 1.38, 0.80-2.38).	Folic Acid	64-70	aldehyde dehydrogenase 2 family member	Homo sapiens	14-19
20130891-10	2010	75% of endogenous bread folates and 94% of breakfast folates were bioaccessible as assessed by TIM.	Folic Acid	53-60	Rho guanine nucleotide exchange factor 5	Homo sapiens	95-98
20592103-0	2010	Plasma folate concentrations are positively associated with risk of estrogen receptor beta negative breast cancer in a Swedish nested case control study.	Folic Acid	7-13	estrogen receptor 2	Homo sapiens	68-90
20649773-11	2010	IMPLICATIONS: From a public health perspective, future monitoring of NTD following implementation of fortification of bread-making flour with folic acid should include a mixed methods approach; reporting birth prevalence on national data and total prevalence on tri-state data.	Folic Acid	142-152	fuzzy planar cell polarity protein	Homo sapiens	69-72
20451541-3	2010	The 5" untranslated region of the hepatocellular Reduced folate carrier (Rfc1; Slc19a1) exhibits AhR binding sites termed dioxin responsive elements (DRE) that have as yet only been found in the promoter region of prototypical TCDD target genes.	Folic Acid	57-63	solute carrier family 19 member 1	Rattus norvegicus	79-86
21119889-9	2010	Similarly, studies performed on human neuronal cell cultures revealed that folate and other B vitamins deprivation from the media resulted in epigenetic modification of the PSEN1 gene.	Folic Acid	75-81	presenilin 1	Homo sapiens	173-178
16332725-8	2006	The impact of ALDH2 Lys+ with ADH2 Arg+ was more evident in low folate consumer (OR = 2.32, 1.19-4.55) than high folate consumer (OR 1.38, 0.80-2.38).	Folic Acid	113-119	aldehyde dehydrogenase 2 family member	Homo sapiens	14-19
16567952-6	2006	A role in folate uptake of megalin, an endocytic receptor for epithelial uptake of various proteins including transcobalamin, is now also indicated by the observation that megalin can mediate uptake of soluble folate receptor.	Folic Acid	10-16	LDL receptor related protein 2	Homo sapiens	27-34
16567952-6	2006	A role in folate uptake of megalin, an endocytic receptor for epithelial uptake of various proteins including transcobalamin, is now also indicated by the observation that megalin can mediate uptake of soluble folate receptor.	Folic Acid	10-16	LDL receptor related protein 2	Homo sapiens	172-179
16371350-7	2006	Finally, we compared the behavior of hTHTR2 with that of hTHTR1 and the human reduced folate carrier (SLC19A1) to underscore commonalities in the cell surface targeting mechanisms of the entire SLC19A gene family.	Folic Acid	86-92	solute carrier family 19 member 1	Homo sapiens	102-109
16365037-11	2006	Feedback metabolic regulation of MTHFS by 10-formylTHF indicates that 5-formylTHF can only accumulate in the presence of 10-formylTHF, providing the first evidence that 5-formylTHF is a storage form of excess formylated folates in mammalian cells.	Folic Acid	220-227	methenyltetrahydrofolate synthetase	Homo sapiens	33-38
16365037-12	2006	The sequestration of 10-formylTHF by MTHFS may explain why de novo purine biosynthesis is protected from common disruptions in the folate-dependent one-carbon network.	Folic Acid	131-137	methenyltetrahydrofolate synthetase	Homo sapiens	37-42
16280378-1	2006	Methotrexate (MTX), a synthetic folate analog, is a tight-binding inhibitor of dihydrofolate reductase (DHFR), a key enzyme for the biosynthesis of purines, thymidylate, and several amino acids.	Folic Acid	32-38	Dihydrofolate reductase	Drosophila melanogaster	79-102
16280378-1	2006	Methotrexate (MTX), a synthetic folate analog, is a tight-binding inhibitor of dihydrofolate reductase (DHFR), a key enzyme for the biosynthesis of purines, thymidylate, and several amino acids.	Folic Acid	32-38	Dihydrofolate reductase	Drosophila melanogaster	104-108
16183151-0	2006	Folic acid reduces adhesion molecules VCAM-1 expession in aortic of rats with hyperhomocysteinemia.	Folic Acid	0-10	vascular cell adhesion molecule 1	Rattus norvegicus	38-44
16183151-1	2006	To investigate effects of supplementation of folic acid on the expression of adhesion molecules VCAM-1 in the aortas of rats with hyperhomocysteinemia.	Folic Acid	45-55	vascular cell adhesion molecule 1	Rattus norvegicus	96-102
16183151-5	2006	Respectively, the aortic expression of adhesion molecules VCAM-1 at protein and mRNA levels were higher in the Met groups than those in the control groups or the Met + Folate groups.	Folic Acid	168-174	vascular cell adhesion molecule 1	Rattus norvegicus	58-64
16183151-7	2006	Folate supplementation prevented elevation of Hcy levels in the blood, and reduced expression of the adhesion molecule VCAM-1.	Folic Acid	0-6	vascular cell adhesion molecule 1	Rattus norvegicus	119-125
15831595-2	2005	Periconceptional maternal folate supplementation reduces NTD risk by 50-70%; however, studies of folate related and other developmental genes in humans have failed to definitively identify a major causal gene for NTD.	Folic Acid	26-32	fuzzy planar cell polarity protein	Homo sapiens	57-60
16041371-3	2005	We used polymorphisms in the genes encoding thiopurine S-methyltransferase (TPMT), gamma-glutamyl hydrolase (GGH) and the reduced folate carrier (SLC19A1) to assess the nature of chromosomal acquisition and its influence on genotype-phenotype concordance in cancer cells.	Folic Acid	130-136	solute carrier family 19 member 1	Homo sapiens	146-153
16026156-8	2005	The electrostatic surface potentials of the human GART domain and Escherichia coli enzyme explain differences in the binding affinity of polyglutamylated folates, and these differences have implications to future chemotherapeutic agent design.	Folic Acid	154-161	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	Homo sapiens	50-54
15705656-8	2005	The induction of abnormal hepatic methionine metabolism through the combination of ethanol feeding with folate deficiency is associated with the activation of CYP2E1 and enhances endoplasmic reticulum stress signals that promote steatosis and apoptosis.	Folic Acid	104-110	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	159-165
21570289-3	2011	Here, the random acylation of amino groups in wild-type RNase A with folic acid is shown to decrease its catalytic activity dramatically, presumably because of the alteration to a key active-site residue, Lys41.	Folic Acid	69-79	ribonuclease A family member 1, pancreatic	Homo sapiens	56-63
20335551-0	2010	MAT1A variants are associated with hypertension, stroke, and markers of DNA damage and are modulated by plasma vitamin B-6 and folate.	Folic Acid	127-133	methionine adenosyltransferase 1A	Homo sapiens	0-5
21792640-4	2011	Among the two communities, Muslim NTD mothers had higher TT genotype showing increased risk for neural tube defects (adjusted OR: 12.9; 95% CI: 1.21-136.8) and lower folic acid supplementation (adjusted OR: 3.5; 95% CI: 1.18-10.22).	Folic Acid	166-176	fuzzy planar cell polarity protein	Homo sapiens	34-37
20233025-2	2010	Folate transporter, encoded by the SLC19A1 gene, commonly referred to as reduced folate carrier (RFC) is a transmembrane protein, which transfers hydrophilic folates across the cell membrane.	Folic Acid	81-87	solute carrier family 19 member 1	Homo sapiens	35-42
22053698-0	2011	Modulatory effect of plasma folate and polymorphisms in one-carbon metabolism on catecholamine methyltransferase (COMT) H108L associated oxidative DNA damage and breast cancer risk.	Folic Acid	28-34	catechol-O-methyltransferase	Homo sapiens	114-118
22053698-1	2011	The present study was aimed to investigate the modulatory role of plasma folate and eight putatively functional polymorphisms of one-carbon metabolism on catecholamine methyltransferase (COMT)-mediated oxidative DNA damage and breast cancer risk.	Folic Acid	73-79	catechol-O-methyltransferase	Homo sapiens	187-191
20233025-2	2010	Folate transporter, encoded by the SLC19A1 gene, commonly referred to as reduced folate carrier (RFC) is a transmembrane protein, which transfers hydrophilic folates across the cell membrane.	Folic Acid	158-165	solute carrier family 19 member 1	Homo sapiens	35-42
20201699-2	2010	Research has found a strong link between periconceptional folic acid consumption and NTD prevention.	Folic Acid	58-68	fuzzy planar cell polarity protein	Homo sapiens	85-88
20018840-1	2010	The reduced folate carrier (RFC) is the major transport system for folates in mammals.	Folic Acid	67-74	solute carrier family 19 member 1	Homo sapiens	4-26
20018840-1	2010	The reduced folate carrier (RFC) is the major transport system for folates in mammals.	Folic Acid	67-74	solute carrier family 19 member 1	Homo sapiens	28-31
20018840-8	2010	Collectively, these results strongly support the notion that each hRFC monomer comprises a single translocation pathway for anionic folate substrates and functions independently of other monomers (i.e. despite an oligomeric structure, hRFC functions as a monomer).	Folic Acid	132-138	solute carrier family 19 member 1	Homo sapiens	66-70
19841321-4	2010	Polymorphisms in genes responsible for pemetrexed transport (reduced folate carrier [SLC19A1]) and metabolism (folylpolyglutamate synthase [FPGS] and gamma-glutamyl hydrolase [GGH]) evaluated in germline DNA (blood) were correlated with treatment outcome.	Folic Acid	69-75	solute carrier family 19 member 1	Homo sapiens	85-92
19650776-2	2009	As folate transport across cell membranes is mediated in part by the reduced folate carrier (RFC1), variants within SLC19A1, the gene that encodes RFC1, may influence disease risk via an effect on folate and/or homocysteine levels.	Folic Acid	77-83	solute carrier family 19 member 1	Homo sapiens	116-123
19650776-3	2009	The present study was undertaken to assess the association between the SLC19A1 c.80G&gt;A polymorphism and folate/homocysteine concentrations in healthy young adults from Northern Ireland.	Folic Acid	107-113	solute carrier family 19 member 1	Homo sapiens	71-78
19687280-1	2009	The reduced folate carrier (RFC) has been postulated to be a major entity for folate transport activity in humans and other mammals.	Folic Acid	12-18	solute carrier family 19 member 1	Homo sapiens	28-31
19706161-14	2009	Genes that were normalized by folic acid played a prominent role in development, such as the transcription factors ID1 and MAFF.	Folic Acid	30-40	inhibitor of DNA binding 1, HLH protein	Homo sapiens	115-118
19534845-1	2009	Soya isoflavones (SIF) and folic acid (FA) both confer the biological properties of antioxidation; however, the mechanism of their antioxidant effect on nervous system development is unclear.	Folic Acid	27-37	glycogen synthase kinase 3 beta	Rattus norvegicus	39-41
19589233-6	2009	Coadministration of folate or its analogues, such as folinate and 5-methyltetrahydrofolate, substrates for both PCFT/HCP1 and RFC1, significantly suppressed the methotrexate influx at pH 5.5, whereas thiamine pyrophosphate, an inhibitor for RFC1 alone, exerted no significant effect.	Folic Acid	20-26	solute carrier family 46 member 1	Rattus norvegicus	112-121
21613404-7	2011	Decoration of human adenovirus type 5 (hAd5) with folate, a known cancer-targeting moiety, provided an ~20-fold increase in infection of murine breast cancer cells (4T1) in a folate receptor-dependent manner.	Folic Acid	50-56	Alzheimer disease, familial, type 5	Homo sapiens	39-43
21108044-6	2011	Real-time PCR indicated that gene expression of MAT1A, MAT2A and DNMT1 were lower in IUGR piglets but could be elevated by maternal folic acid supplementation.	Folic Acid	132-142	methionine adenosyltransferase 1A	Homo sapiens	48-53
21149331-10	2010	Higher RBC folate levels were associated with higher levels of both ERalpha (P = 0.03) and SFRP1 methylation (P = 0.01).	Folic Acid	11-17	secreted frizzled related protein 1	Homo sapiens	91-96
21215183-2	2010	METHOD: The folic acid deficient zebrafish model was constructed by using both the folic acid antagonist methotrexate (MTX) and knocking-down dhfr (dihydrofolate reductase gene).	Folic Acid	12-22	dihydrofolate reductase	Danio rerio	148-171
20833714-0	2010	Folic acid remodels chromatin on Hes1 and Neurog2 promoters during caudal neural tube development.	Folic Acid	0-10	hes family bHLH transcription factor 1	Mus musculus	33-37
20833714-0	2010	Folic acid remodels chromatin on Hes1 and Neurog2 promoters during caudal neural tube development.	Folic Acid	0-10	neurogenin 2	Mus musculus	42-49
20833714-10	2010	Thus, one of the mechanisms by which folate may rescue the Sp(-/-) phenotype is by increasing the expression of KDM6B, which in turn decreases H3K27 methylation marks on Hes1 and Neurog2 promoters thereby affecting gene transcription.	Folic Acid	37-43	hes family bHLH transcription factor 1	Mus musculus	170-174
20833714-10	2010	Thus, one of the mechanisms by which folate may rescue the Sp(-/-) phenotype is by increasing the expression of KDM6B, which in turn decreases H3K27 methylation marks on Hes1 and Neurog2 promoters thereby affecting gene transcription.	Folic Acid	37-43	neurogenin 2	Mus musculus	179-186
20827489-4	2010	All PGA were positive for Mucin 6 (deep mucoid glands), which they express over the whole lesion up to the surface.	Folic Acid	4-7	mucin 6, oligomeric mucus/gel-forming	Homo sapiens	26-33
15871139-6	2005	In this segment, each family displayed one of two different missense mutations that altered the coding sequence of SLC19A3, the gene for a transporter related to the reduced-folate (encoded by SLC19A1) and thiamin (encoded by SLC19A2) transporters.	Folic Acid	174-180	solute carrier family 19 member 3	Homo sapiens	115-122
15871139-6	2005	In this segment, each family displayed one of two different missense mutations that altered the coding sequence of SLC19A3, the gene for a transporter related to the reduced-folate (encoded by SLC19A1) and thiamin (encoded by SLC19A2) transporters.	Folic Acid	174-180	solute carrier family 19 member 1	Homo sapiens	193-200
15846510-1	2005	The reduced-folate carrier (Rfc-1), previously also called methotrexate carrier-1 (MTX-1), was recently identified as accounting for approximately 30% of the methotrexate (Mtx) uptake into rat kidney slices.	Folic Acid	12-18	solute carrier family 19 member 1	Rattus norvegicus	59-81
15846510-1	2005	The reduced-folate carrier (Rfc-1), previously also called methotrexate carrier-1 (MTX-1), was recently identified as accounting for approximately 30% of the methotrexate (Mtx) uptake into rat kidney slices.	Folic Acid	12-18	solute carrier family 19 member 1	Rattus norvegicus	83-88
15814835-3	2005	Female mice (6 wk old) were lethally irradiated and transplanted with male bone marrow (BM) cells and later assigned into control, folic acid-treatment, and folic acid-treatment with granulocyte-colony stimulating factor (G-CSF), and control with G-CSF.	Folic Acid	157-167	colony stimulating factor 3 (granulocyte)	Mus musculus	183-220
15850889-1	2005	BACKGROUND: Upon discovering an NTD incidence rate of 27/10,000 in a Texas border county, the Texas Department of Health initiated folic acid intervention for prevention of recurrent NTDs in this predominantly Mexican-American population.	Folic Acid	131-141	fuzzy planar cell polarity protein	Homo sapiens	32-35
15899835-2	2005	Here we show that MRP5/ABCC5 is also an antifolate and folate exporter based on the following evidence: (a) Using membrane vesicles from HEK293 cells, we show that MRP5 transports both MTX (KM = 1.3 mmol/L and VMAX = 780 pmol per mg protein per minute) and folic acid (KM = 1.0 mmol/L and VMAX = 875 pmol per mg protein per minute).	Folic Acid	257-267	ATP binding cassette subfamily C member 5	Homo sapiens	164-168
19589233-6	2009	Coadministration of folate or its analogues, such as folinate and 5-methyltetrahydrofolate, substrates for both PCFT/HCP1 and RFC1, significantly suppressed the methotrexate influx at pH 5.5, whereas thiamine pyrophosphate, an inhibitor for RFC1 alone, exerted no significant effect.	Folic Acid	20-26	solute carrier family 19 member 1	Rattus norvegicus	126-130
20426397-1	2010	The redox properties of Fe and Zn complexes coordinated by an alpha-diimine based N(4)-macrocyclic ligand (TIM) have been examined using spectroscopic methods and density functional theory (DFT) computational analysis.	Folic Acid	82-86	Rho guanine nucleotide exchange factor 5	Homo sapiens	107-110
20360131-6	2010	Chronic alcohol feeding of rats (4 wk; 36% of calories from ethanol) led to a significant decrease in folate uptake by freshly isolated primary pancreatic acinar cells compared with cells from pair-fed controls; this effect was associated with a parallel decrease in the level of expression of RFC and PCFT.	Folic Acid	102-108	solute carrier family 46 member 1	Rattus norvegicus	302-306
20360131-7	2010	These studies reveal that folate uptake by pancreatic acinar cells is via a regulated carrier-mediated process which may involve RFC and PCFT.	Folic Acid	26-32	solute carrier family 46 member 1	Rattus norvegicus	137-141
20360131-8	2010	In addition, chronic alcohol feeding leads to a marked inhibition in folate uptake by pancreatic acinar cells, an effect that is associated with reduction in level of expression of RFC and PCFT.	Folic Acid	69-75	solute carrier family 46 member 1	Rattus norvegicus	189-193
19932120-1	2010	AIMS: To determine whether increased N-acetyltransferase (NAT) activity might have a toxic effect during development and an influence on folate levels since previous work has shown that only low levels of exogenous NAT can be achieved in constitutionally transgenic mice (Cao et al.	Folic Acid	137-143	bromodomain containing 2	Mus musculus	58-61
19360465-3	2010	Of the analyzed genes, ERCC2, XRCC1, XRCC2, XRCC3 and Lig4 participate in DNA repair, TP53 in cell cycle check point control, AIB1, AR, COMT, CYP11A1, CYP17A1, CYP19A1, HSD17 and PGR in steroid hormone biosynthesis/metabolism/signaling, TYMS in folate metabolism and HER2, IL6, LRP1, TGFB and TGFBR1 affect cell growth.	Folic Acid	245-251	X-ray repair cross complementing 2	Homo sapiens	37-42
19360465-3	2010	Of the analyzed genes, ERCC2, XRCC1, XRCC2, XRCC3 and Lig4 participate in DNA repair, TP53 in cell cycle check point control, AIB1, AR, COMT, CYP11A1, CYP17A1, CYP19A1, HSD17 and PGR in steroid hormone biosynthesis/metabolism/signaling, TYMS in folate metabolism and HER2, IL6, LRP1, TGFB and TGFBR1 affect cell growth.	Folic Acid	245-251	catechol-O-methyltransferase	Homo sapiens	136-140
19360465-3	2010	Of the analyzed genes, ERCC2, XRCC1, XRCC2, XRCC3 and Lig4 participate in DNA repair, TP53 in cell cycle check point control, AIB1, AR, COMT, CYP11A1, CYP17A1, CYP19A1, HSD17 and PGR in steroid hormone biosynthesis/metabolism/signaling, TYMS in folate metabolism and HER2, IL6, LRP1, TGFB and TGFBR1 affect cell growth.	Folic Acid	245-251	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	151-158
19360465-3	2010	Of the analyzed genes, ERCC2, XRCC1, XRCC2, XRCC3 and Lig4 participate in DNA repair, TP53 in cell cycle check point control, AIB1, AR, COMT, CYP11A1, CYP17A1, CYP19A1, HSD17 and PGR in steroid hormone biosynthesis/metabolism/signaling, TYMS in folate metabolism and HER2, IL6, LRP1, TGFB and TGFBR1 affect cell growth.	Folic Acid	245-251	progesterone receptor	Homo sapiens	179-182
19589233-6	2009	Coadministration of folate or its analogues, such as folinate and 5-methyltetrahydrofolate, substrates for both PCFT/HCP1 and RFC1, significantly suppressed the methotrexate influx at pH 5.5, whereas thiamine pyrophosphate, an inhibitor for RFC1 alone, exerted no significant effect.	Folic Acid	20-26	solute carrier family 19 member 1	Rattus norvegicus	241-245
19162536-5	2009	These experiments confirm that anthracene could combine with the pterin ring of folic acid through pi-pi donor-acceptor interaction (EDA) and induce the protonation process in FA upon strengthening electron accepting ability of PT ring.	Folic Acid	80-90	ectodysplasin A	Homo sapiens	133-136
19571232-1	2009	The reduced folate carrier (RFC) is a major folate transport system in mammalian cells.	Folic Acid	12-18	solute carrier family 19 member 1	Homo sapiens	28-31
19571232-2	2009	RFC is highly expressed in the intestine and believed to play a role in folate absorption.	Folic Acid	72-78	solute carrier family 19 member 1	Homo sapiens	0-3
19571232-8	2009	Coexpression of DYNLRB1 with hRFC led to a significant (P &lt; 0.05) increase in folate uptake.	Folic Acid	81-87	solute carrier family 19 member 1	Homo sapiens	29-33
19329763-3	2009	In the mouse model of folic acid-induced AKI, we observed a marked increase of MMP9 activity in the S3 segment of the proximal tubule (S3PT), correlating with the apoptotic phase.	Folic Acid	22-32	matrix metallopeptidase 9	Mus musculus	79-83
20049736-8	2009	This suggested that the ability of methotrexate to modulate folate synthesis via inhibition of DHFR, may explain MSH2 selectivity.	Folic Acid	60-66	mutS homolog 2	Homo sapiens	113-117
19174154-2	2009	This class is characterized by retention of dihydrofolate reductase (DHFR; EC 1.5.1.3) as their locus of action and transport by the reduced folate carrier (RFC; SLC19A1), but their lack of metabolism by known pathways of antifolate (e.g., methotrexate (MTX)) metabolism.	Folic Acid	51-57	solute carrier family 19 member 1	Homo sapiens	162-169
18180053-9	2008	However, in the rabbits treated with folate, Hcy concentration, NT, NA and MMP-9 mRNA expression were lower than those in the Meth group.	Folic Acid	37-43	matrix metalloproteinase-9	Oryctolagus cuniculus	75-80
18180053-11	2008	CONCLUSION: This study suggested that folate could decrease the level of Hcy, reverse the Hhcy-induced exacerbation of neointima formation in rabbits following balloon injury, and the mechanisms in it may be related to the suppressive effect of folate on the expression of MMP-9 mRNA in arterial wall.	Folic Acid	38-44	matrix metalloproteinase-9	Oryctolagus cuniculus	273-278
18801628-2	2008	Polymorphic variants of genes encoding key enzymes of folate and methionine metabolism may have an impact on catecholamine catabolism conducted by catechol-O-methyltransferase.	Folic Acid	54-60	catechol-O-methyltransferase	Homo sapiens	147-175
18987184-4	2008	Here, we show that folate deprivation in neuroblastoma cells induces downregulation of PP2A leucine carboxyl methyltransferase-1 (LCMT-1) expression, resulting in progressive accumulation of newly synthesized demethylated PP2A pools, concomitant loss of B(alpha), and ultimately cell death.	Folic Acid	19-25	leucine carboxyl methyltransferase 1	Mus musculus	92-128
18987184-4	2008	Here, we show that folate deprivation in neuroblastoma cells induces downregulation of PP2A leucine carboxyl methyltransferase-1 (LCMT-1) expression, resulting in progressive accumulation of newly synthesized demethylated PP2A pools, concomitant loss of B(alpha), and ultimately cell death.	Folic Acid	19-25	leucine carboxyl methyltransferase 1	Mus musculus	130-136
18987184-6	2008	Overexpression of either LCMT-1 or B(alpha) is sufficient to protect cells against the accumulation of demethylated PP2A, increased tau phosphorylation, and cell death induced by folate starvation.	Folic Acid	179-185	leucine carboxyl methyltransferase 1	Mus musculus	25-31
18987184-11	2008	They establish LCMT-1- and B(alpha)-containing PP2A holoenzymes as key mediators of the role of folate in the brain.	Folic Acid	96-102	leucine carboxyl methyltransferase 1	Mus musculus	15-21
18703672-4	2008	We show that Hcy exerts an antiproliferative effect on basic fibroblast growth factor (bFGF) -stimulated NPCs isolated from the postnatal subventricular zone (SVZ), accompanied by inactivation of the extracellular signal-regulated kinase (Erk1/2) and inhibition of Erk1/2-dependent expression of cyclin E. Using a mice model we show that, under normal folate conditions, HHcy exerts an inhibitory effect on adult brain neurogenesis.	Folic Acid	352-358	fibroblast growth factor 2	Mus musculus	55-92
18182479-1	2008	Reduced folate carrier (RFC) is the major membrane transporter for folates and antifolates in mammalian tissues.	Folic Acid	67-74	solute carrier family 19 member 1	Homo sapiens	0-28
18326613-8	2008	Women in the highest quintile group relative to those in the lowest quintile had multivariate RRs of 1.42 (95% CI: 1.00, 2.02) for plasma folate (P for trend = 0.21), 0.91 (95% CI: 0.63, 1.30) for plasma PLP (P for trend = 0.48), and 1.29 (95% CI: 0.92, 1.82) for plasma vitamin B-12 (P for trend = 0.18).	Folic Acid	138-144	pyridoxal phosphatase	Homo sapiens	204-207
18326613-9	2008	However, higher plasma folate concentrations were moderately associated with an increased risk of developing premenopausal breast cancer (P for trend = 0.04) and for developing estrogen receptor (ER)-positive or progesterone receptor (PR)-positive breast tumors (P for trend &lt; or = 0.06).	Folic Acid	23-29	progesterone receptor	Homo sapiens	212-233
18326613-9	2008	However, higher plasma folate concentrations were moderately associated with an increased risk of developing premenopausal breast cancer (P for trend = 0.04) and for developing estrogen receptor (ER)-positive or progesterone receptor (PR)-positive breast tumors (P for trend &lt; or = 0.06).	Folic Acid	23-29	progesterone receptor	Homo sapiens	235-237
18850227-0	2008	Change in platelet endothelial cell adhesion molecule-1 immunoreactivity in the dentate gyrus in gerbils fed a folate-deficient diet.	Folic Acid	111-117	platelet and endothelial cell adhesion molecule 1	Homo sapiens	10-55
18850227-2	2008	We examined whether folate deficiency affects platelet endothelial cell adhesion molecule-1 (PECAM-1), which is an immunoglobulin-associated cell adhesion molecule and mediates the final common pathway of neutrophil transendothelial migration, in blood vessels in the gerbil dentate gyrus after transient forebrain ischemia.	Folic Acid	20-26	platelet and endothelial cell adhesion molecule 1	Homo sapiens	46-91
18162191-11	2008	DNA for human reduced folate carrier (SLC19A1) genomic sequence was also detected in 90% of the QS-R extracts.	Folic Acid	22-28	solute carrier family 19 member 1	Homo sapiens	38-45
17983788-1	2008	The ubiquitously expressed reduced folate carrier (RFC) or SLC19A1 is recognized to be an essential transport system for folates in mammalian cells and tissues.	Folic Acid	121-128	solute carrier family 19 member 1	Homo sapiens	27-49
17983788-1	2008	The ubiquitously expressed reduced folate carrier (RFC) or SLC19A1 is recognized to be an essential transport system for folates in mammalian cells and tissues.	Folic Acid	121-128	solute carrier family 19 member 1	Homo sapiens	51-54
17983788-1	2008	The ubiquitously expressed reduced folate carrier (RFC) or SLC19A1 is recognized to be an essential transport system for folates in mammalian cells and tissues.	Folic Acid	121-128	solute carrier family 19 member 1	Homo sapiens	59-66
18071956-2	2007	Inhibitory effects on IL-1 and TNF production have been attributed to the folate analog methotrexate.	Folic Acid	74-80	tumor necrosis factor-like	Rattus norvegicus	31-34
17877400-6	2007	In order to specifically target BH3 peptides to cancer cells, we synthesized a trifunctional, G5-PAMAM-based nanodevice to which folic acid was conjugated as a targeting agent, along with fluorescein isothiocyanate as the reporter agent and BH3 peptides that were used to induce apoptosis.	Folic Acid	129-139	G-patch domain and ankyrin repeats 1	Homo sapiens	94-102
17482557-1	2007	Folate-activated one-carbon units are derived from serine through the activity of the pyridoxal-phosphate (PLP)-dependent isozymes of serine hydroxymethyltransferase (SHMT).	Folic Acid	0-6	pyridoxal phosphatase	Homo sapiens	107-110
17487363-3	2007	The transfection of Cx43 plasmid DNA (pCMV-Cx43) into human nasopharyngeal cancer KB cells using folate-linked nanoparticles induced inhibition of cell growth.	Folic Acid	97-103	gap junction protein alpha 1	Homo sapiens	20-24
17487363-3	2007	The transfection of Cx43 plasmid DNA (pCMV-Cx43) into human nasopharyngeal cancer KB cells using folate-linked nanoparticles induced inhibition of cell growth.	Folic Acid	97-103	gap junction protein alpha 1	Homo sapiens	43-47
16820193-0	2007	Polymorphism C776G in the transcobalamin II gene and homocysteine, folate and vitamin B12 concentrations.	Folic Acid	67-73	transcobalamin 2	Homo sapiens	26-43
16917939-10	2006	Differences in allele frequency and/or significant gene-gene interactions were found for relevant genes encoding the reduced folate carrier (RFC 80G &gt; A), transcobalamin II (TCN2 776G &gt; C), catechol-O-methyltransferase (COMT 472G &gt; A), methylenetetrahydrofolate reductase (MTHFR 677C &gt; T and 1298A &gt; C), and glutathione-S-transferase (GST M1).	Folic Acid	125-131	catechol-O-methyltransferase	Homo sapiens	196-224
17050573-9	2006	The predictive value of these profiles was verified by demonstrating that NTDs of Ski-/-mutant mice, whose profile suggested resistance to folate supplementation, were not suppressed with dietary folate supplementation.	Folic Acid	139-145	ski sarcoma viral oncogene homolog (avian)	Mus musculus	82-85
17055997-6	2006	Expression of the MTHFS cDNA in MCF-7 cells increased the concentration of NADA required to deplete cellular folate.	Folic Acid	109-115	methenyltetrahydrofolate synthetase	Homo sapiens	18-23
17003819-6	2006	We found that TWEAK and Fn14 expression was increased in experimental acute renal failure induced by folic acid.	Folic Acid	101-111	tumor necrosis factor (ligand) superfamily, member 12	Mus musculus	14-19
17003819-6	2006	We found that TWEAK and Fn14 expression was increased in experimental acute renal failure induced by folic acid.	Folic Acid	101-111	tumor necrosis factor receptor superfamily, member 12a	Mus musculus	24-28
17058407-9	2006	CONCLUSIONS: Following the Ministry of Health guidelines on folic acid supplementation for women in the reproductive age, a marked reduction in the rates of NTD was observed.	Folic Acid	60-70	fuzzy planar cell polarity protein	Homo sapiens	157-160
16877991-0	2006	Alanine amino transferase concentrations are linked to folate intakes and methylenetetrahydrofolate reductase polymorphism in obese adolescent girls.	Folic Acid	55-61	glutamic--pyruvic transaminase	Homo sapiens	0-25
16877991-9	2006	Alanine amino transferase was correlated negatively to folate intake (r = -0.32, P = 0.024) (n = 50) and positively to homocysteine concentrations (r = 0.30, P = 0.025).	Folic Acid	55-61	glutamic--pyruvic transaminase	Homo sapiens	0-25
16585211-0	2006	5-amino-4-imidazolecarboxamide riboside potentiates both transport of reduced folates and antifolates by the human reduced folate carrier and their subsequent metabolism.	Folic Acid	78-85	solute carrier family 19 member 1	Homo sapiens	115-137
16900951-4	2006	At pH 7.5, uptake of 3H-folic acid was (i) Na+-independent; (ii) inhibited by folic acid and MTX, but not by 5-MTHF; (iii) inhibited by SITS, but not by DIDS; (iv) not affected by FCCP; (v) inhibited by monensin (but not by cytochalasin D); (vi) trans-inhibited by folic acid (but not by MTX); and (vii) inhibited by an anti-RFC antibody.	Folic Acid	24-34	solute carrier family 19 member 1	Homo sapiens	325-328
15705656-3	2005	The effects of ethanol feeding or folate-deficient diets, singly or in combination, on cytochrome P-450 2E1 (CYP2E1) and signal pathways for apoptosis and steatosis were analyzed using microarray, real-time PCR, and immunoblotting techniques.	Folic Acid	34-40	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	87-107
15705656-3	2005	The effects of ethanol feeding or folate-deficient diets, singly or in combination, on cytochrome P-450 2E1 (CYP2E1) and signal pathways for apoptosis and steatosis were analyzed using microarray, real-time PCR, and immunoblotting techniques.	Folic Acid	34-40	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	109-115
15705656-5	2005	Liver CYP2E1 and the endoplasmic reticulum stress signals glucose-regulated protein 78 (GRP78), caspase 12, and sterol regulatory element binding protein-1c (SREBP-1c) were each activated in pigs fed folate-deficient or ethanol diets singly or in combination.	Folic Acid	200-206	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	6-12
15657365-7	2005	Confocal microscopy with folate-deprived cells revealed that cytoplasmic BCRP colocalized with calnexin, an established endoplasmic reticulum resident.	Folic Acid	25-31	calnexin	Homo sapiens	95-103
15703271-4	2005	With the use of targeted inactivation of the folate binding protein 1 (folbp1) and folate binding protein 2 (folbp2) genes in mice, the role of folate receptors in renal epithelial folate reabsorption was evaluated during low and normal folate intake.	Folic Acid	83-89	folate receptor 2 (fetal)	Mus musculus	109-115
15709201-9	2005	These data support the concept that the contribution to pemetrexed activity by inhibition of GARFT, particularly at low folate levels, is a contributing factor to drug activity but relative inhibition of TS and GARFT may vary among human tumors and cell lines.	Folic Acid	120-126	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	Homo sapiens	93-98
15385270-2	2005	The major intestinal folate transport activity has a low-pH optimum, and the current paradigm is that this process is mediated by the reduced folate carrier (RFC), despite the fact that this carrier has a neutral pH optimum in leukemia cells.	Folic Acid	21-27	solute carrier family 19 member 1	Homo sapiens	158-161
15385270-3	2005	The current study addressed the question of whether constitutive low-pH folate transport activity in IEC-6 cells is mediated by RFC.	Folic Acid	72-78	solute carrier family 19 member 1	Homo sapiens	128-131
15385270-10	2005	These results indicate that in IEC-6 cells, folate transport at neutral pH is mediated predominantly by RFC; however, the folate transport activity at pH 5.5 is RFC independent.	Folic Acid	44-50	solute carrier family 19 member 1	Homo sapiens	104-107
15385270-10	2005	These results indicate that in IEC-6 cells, folate transport at neutral pH is mediated predominantly by RFC; however, the folate transport activity at pH 5.5 is RFC independent.	Folic Acid	122-128	solute carrier family 19 member 1	Homo sapiens	161-164
15630450-5	2005	We found significantly lower expression of the reduced folate carrier (SLC19A1, an MTX uptake transporter) in E2A-PBX1 ALL, significantly higher expression of breast cancer resistance protein (ABCG2, an MTX efflux transporter) in TEL-AML1 ALL, and lower expression of FPGS (which catalyzes formation of MTXPG) in T-lineage ALL, consistent with lower MTXPG accumulation in these ALL subtypes.	Folic Acid	55-61	solute carrier family 19 member 1	Homo sapiens	71-78
14551190-1	2004	The human reduced folate carrier (hRFC) is the major uptake route for antifolates used in cancer chemotherapy.	Folic Acid	18-24	solute carrier family 19 member 1	Homo sapiens	34-38
14517211-2	2003	We now report that the p53-dependent G1 checkpoint is blocked in human carcinoma cell lines after inhibition of de novo purine synthesis by folate analogs inhibitory to glycinamide ribonucleotide formyltransferase (GART).	Folic Acid	140-146	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	Homo sapiens	169-213
14517211-2	2003	We now report that the p53-dependent G1 checkpoint is blocked in human carcinoma cell lines after inhibition of de novo purine synthesis by folate analogs inhibitory to glycinamide ribonucleotide formyltransferase (GART).	Folic Acid	140-146	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	Homo sapiens	215-219
14745917-4	2003	RESULTS: Folbp2(-/-) mice had higher VPA-induced frequencies of embryonic lethality and exencephaly than did the wild-type control mice during folate supplementation and a control diet, respectively.	Folic Acid	143-149	folate receptor 2 (fetal)	Mus musculus	9-15
14745917-7	2003	CONCLUSIONS: Unlike our previous findings with arsenate, enhanced susceptibility of Folbp2(-/-) mice to in utero VPA exposure was demonstrated in some dietary folate regimens.	Folic Acid	159-165	folate receptor 2 (fetal)	Mus musculus	84-90
14682443-5	2003	RESULTS: Riboflavin and thiamin from food sources, vitamin B12 supplements, and total (food and supplements) folate displayed inverse, dose-responsive associations with high-grade SIL (HSIL).	Folic Acid	109-115	STIL centriolar assembly protein	Homo sapiens	180-183
14682443-6	2003	Riboflavin from food sources and total folate also demonstrated inverse, dose-responsive associations with low-grade SIL (LSIL).	Folic Acid	39-45	STIL centriolar assembly protein	Homo sapiens	117-120
14622275-2	2003	The gene associated with this disease encodes for thiamine transporter 1 (THTR1), a member of the SLC19 solute carrier family including THTR2 and the reduced folate carrier (RFC).	Folic Acid	158-164	solute carrier family 19 member 2	Homo sapiens	50-72
15808372-8	2005	This decreasing trend in rate and severity of NTD affected births was most dramatic prior to either food fortification or periconceptual folic acid supplementation.	Folic Acid	137-147	fuzzy planar cell polarity protein	Homo sapiens	46-49
15735091-5	2005	The inclusion of dietary folic acid for 8 wk caused plasma homocysteine levels to be the same as in control rats and it significantly upregulated the cerebral expression of GLUT-1 that was significantly reduced by hyperhomocysteinemia.	Folic Acid	25-35	solute carrier family 2 member 1	Rattus norvegicus	173-179
16040340-1	2005	Recently, the rat genome project revealed the genomic sequence of slc19a1, coding for the methotrexate carrier-1, identical to the reduced folate carrier-1 of humans, on rat chromosome 20.	Folic Acid	139-145	solute carrier family 19 member 1	Rattus norvegicus	66-73
16040340-1	2005	Recently, the rat genome project revealed the genomic sequence of slc19a1, coding for the methotrexate carrier-1, identical to the reduced folate carrier-1 of humans, on rat chromosome 20.	Folic Acid	139-145	solute carrier family 19 member 1	Rattus norvegicus	90-112
21783456-4	2005	Folbp2(-/-) mice were found to have slightly lower plasma folate levels than wildtype mice.	Folic Acid	58-64	folate receptor 2 (fetal)	Mus musculus	0-6
15607954-4	2005	Here we demonstrate that BACE (beta-secretase), as well as PS1, is regulated by methylation and that the reduction of folate and vitamin B12 in culture medium can cause a reduction of SAM levels with consequent increase in presenilin1 and BACE levels and with increase in A beta production.	Folic Acid	118-124	presenilin 1	Homo sapiens	59-62
15607954-4	2005	Here we demonstrate that BACE (beta-secretase), as well as PS1, is regulated by methylation and that the reduction of folate and vitamin B12 in culture medium can cause a reduction of SAM levels with consequent increase in presenilin1 and BACE levels and with increase in A beta production.	Folic Acid	118-124	presenilin 1	Homo sapiens	223-234
15218023-3	2004	We observe an up-regulation in initiation of BER in liver of the folate-deficient mice, as evidenced by an increase in uracil DNA glycosylase protein (30%, p &lt; 0.01) and activity (31%, p &lt; 0.05).	Folic Acid	65-71	uracil DNA glycosylase	Mus musculus	119-141
15297414-1	2004	The human reduced folate carrier (hRFC) is reported to be regulated by up to seven alternatively spliced noncoding exons (A1, A2, A, B, C, D, and E).	Folic Acid	18-24	solute carrier family 19 member 1	Homo sapiens	34-38
14998787-11	2004	RT-PCR and Western blot analysis showed expression of the human reduced folate carrier (hRFC) at the RNA and protein levels, respectively.	Folic Acid	72-78	solute carrier family 19 member 1	Homo sapiens	88-92
14998787-12	2004	The functional contribution of hRFC in carrier-mediated folate uptake was confirmed by gene silencing using gene-specific small interfering RNA.	Folic Acid	56-62	solute carrier family 19 member 1	Homo sapiens	31-35
14998787-15	2004	The results also show the involvement of hRFC in the uptake process and suggest the possible involvement of intracellular cAMP- and PTK-mediated pathways in the regulation of folate uptake.	Folic Acid	175-181	solute carrier family 19 member 1	Homo sapiens	41-45
14602046-1	2004	The hRFC (human reduced folate carrier) is the major membrane transporter for both reduced folates and antifolates in human tissues and tumours.	Folic Acid	24-30	solute carrier family 19 member 1	Homo sapiens	4-8
14602046-1	2004	The hRFC (human reduced folate carrier) is the major membrane transporter for both reduced folates and antifolates in human tissues and tumours.	Folic Acid	91-98	solute carrier family 19 member 1	Homo sapiens	4-8
14662146-7	2004	The folic acid+glycine supplement tended (P&lt;0.07) to increase allantoic content of PGE2 and TGF-beta2 in all sows and increased (P&lt;0.05) endometrial expression of COX2, especially in NYL sows.	Folic Acid	4-14	cytochrome c oxidase subunit II	Sus scrofa	169-173
14662146-13	2004	Finally, in YL and NYL sows, folic acid+glycine supplement decreased (P&lt;0.05) the endometrial expression of GM-CSF but not in ML sows.	Folic Acid	29-39	colony stimulating factor 2	Sus scrofa	111-117
14662146-14	2004	In summary, folic acid+glycine supplement altered endometrial expression of GM-CSF and uterine metabolism of prostaglandins during the post-attachment period of porcine embryos but some of these effects were manifest only in Meishan and nulliparous sows.	Folic Acid	12-22	colony stimulating factor 2	Sus scrofa	76-82
15050876-4	2004	The aim of this study was to assess the level of awareness regarding folic acid and its effect in the prevention of NTD among Arab Israeli women of childbearing age.	Folic Acid	69-79	fuzzy planar cell polarity protein	Homo sapiens	116-119
12970065-9	2004	In folate supplemented rats, aging induced the down-regulation of vascular endothelial growth factor and caspase-2.	Folic Acid	3-9	caspase 2	Rattus norvegicus	105-114
15456641-6	2004	In the present study, we provide evidence of the ability of different natural polyphenols and of folic acid derivatives to inhibit the biotransformation of alcohol to acetaldehyde by rat breast cytosolic XOR.	Folic Acid	97-107	xanthine dehydrogenase	Rattus norvegicus	204-207
14584080-2	2003	Although MTX uptake proceeds primarily through the reduced folate carrier (RFC) protein and efflux occurs via multidrug resistance protein 1 (MRP1), RFC protein expression in osteosarcoma remains unexamined.	Folic Acid	59-65	solute carrier family 19 member 1	Homo sapiens	75-78
14652292-9	2003	These data indicate that dietary folate supplementation at 4x the basal dietary requirement significantly suppresses UC-associated colorectal carcinogenesis in the IL-2(null) x beta(2)m(null) mice.	Folic Acid	33-39	beta-2 microglobulin	Mus musculus	177-185
14608078-5	2003	We examined the effect of folic acid supplementation for 6 wk and 12 mo (5 mg/d for 1 wk, 1 mg/d for 37 wk and 0.4 mg/d for the remaining 14 wk) on LOX-1 mRNA levels and on oxLDL-induced release of tumor necrosis factor alpha from peripheral blood mononuclear cells in hyperhomocysteinemic individuals.	Folic Acid	26-36	oxidized low density lipoprotein receptor 1	Homo sapiens	148-153
14608078-8	2003	Folic acid treatment led to a normalization of homocysteine levels accompanied by a reduction in LOX-1 gene expression (P &lt; 0.02) and in oxLDL-stimulated release of TNFalpha (P &lt; 0.05).	Folic Acid	0-10	oxidized low density lipoprotein receptor 1	Homo sapiens	97-102
14608078-9	2003	These novel findings suggest both that homocysteine exerts its atherogenic effect in part by elevating levels of LOX-1, thereby enhancing oxLDL-induced inflammatory responses, and most important, that folic acid supplementation may downregulate these responses.	Folic Acid	201-211	oxidized low density lipoprotein receptor 1	Homo sapiens	113-118
12969123-10	2003	Acute tubular injury induced by folic acid was characterized by AT2 overexpression and apoptosis in tubular cells.	Folic Acid	32-42	angiotensin II receptor type 2	Homo sapiens	64-67
12974624-0	2003	Structure of avian AICAR transformylase with a multisubstrate adduct inhibitor beta-DADF identifies the folate binding site.	Folic Acid	104-110	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	19-24
12974624-3	2003	Identification of the location of the AICAR transformylase active site was previously elucidated from the crystal structure of the avian ATIC with bound substrate AICAR; however, due to the absence of any bound folate, the folate binding region of the active site could not be identified.	Folic Acid	211-217	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	38-43
12974624-3	2003	Identification of the location of the AICAR transformylase active site was previously elucidated from the crystal structure of the avian ATIC with bound substrate AICAR; however, due to the absence of any bound folate, the folate binding region of the active site could not be identified.	Folic Acid	223-229	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	38-43
12974624-3	2003	Identification of the location of the AICAR transformylase active site was previously elucidated from the crystal structure of the avian ATIC with bound substrate AICAR; however, due to the absence of any bound folate, the folate binding region of the active site could not be identified.	Folic Acid	223-229	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	137-141
12974624-3	2003	Identification of the location of the AICAR transformylase active site was previously elucidated from the crystal structure of the avian ATIC with bound substrate AICAR; however, due to the absence of any bound folate, the folate binding region of the active site could not be identified.	Folic Acid	223-229	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	163-168
12974624-5	2003	Beta-DADF encompasses both the AICAR and folate moieties into a single covalently linked entity, thereby allowing for the characterization of the folate binding pocket of the AICAR transformylase active site.	Folic Acid	146-152	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	175-180
12628490-0	2003	The role of multidrug resistance proteins MRP1, MRP2 and MRP3 in cellular folate homeostasis.	Folic Acid	74-80	ATP binding cassette subfamily C member 3	Homo sapiens	57-61
12628490-3	2003	In MRP1, MRP2 and MRP3-transfected 2008 human ovarian carcinoma cells total cellular folate content was 32-38% lower than in 2008 cells (105+/-14pmolfolate/mgprotein) when grown in medium containing 2.3 microM folic acid (FA).	Folic Acid	85-91	ATP binding cassette subfamily C member 3	Homo sapiens	18-22
12628490-3	2003	In MRP1, MRP2 and MRP3-transfected 2008 human ovarian carcinoma cells total cellular folate content was 32-38% lower than in 2008 cells (105+/-14pmolfolate/mgprotein) when grown in medium containing 2.3 microM folic acid (FA).	Folic Acid	210-220	ATP binding cassette subfamily C member 3	Homo sapiens	18-22
12628490-5	2003	However, when cells were challenged under folate-depleted conditions with a short exposure (4 hr) to FA or leucovorin, MRP1 and MRP3 overexpressing cells were impaired in their growth.	Folic Acid	42-48	ATP binding cassette subfamily C member 3	Homo sapiens	128-132
12535338-2	2003	The predicted amino acid sequence encoded by the GLA1 gene is homologous to the amino acid sequences of folylpolyglutamate synthetase (FPGS) and dihydrofolate synthetase (DHFS), which participate in folate biosynthesis.	Folic Acid	152-158	Folylpolyglutamate synthetase family protein	Arabidopsis thaliana	49-53
12501179-2	2002	The formyl transfer reaction catalyzed by the AICAR Tfase domain is substantially more demanding than that catalyzed by the other folate-dependent enzyme of the purine biosynthesis pathway, GAR transformylase.	Folic Acid	130-136	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	46-51
12516902-12	2002	CONCLUSIONS: The data presented here will serve as a basis for evaluating the impact of the Ministry of Health recommendations for folic acid supplementation on the incidence of NTD.	Folic Acid	131-141	fuzzy planar cell polarity protein	Homo sapiens	178-181
12234990-1	2002	The class of folate antimetabolites typified by (6R)-dideazatetrahydrofolate (lometrexol, DDATHF) are specific inhibitors of de novo purine synthesis because of potent inhibition of glycinamide ribonucleotide formyltransferase (GART) but do not induce detectable levels of DNA strand breaks.	Folic Acid	13-19	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	Homo sapiens	182-226
12234990-1	2002	The class of folate antimetabolites typified by (6R)-dideazatetrahydrofolate (lometrexol, DDATHF) are specific inhibitors of de novo purine synthesis because of potent inhibition of glycinamide ribonucleotide formyltransferase (GART) but do not induce detectable levels of DNA strand breaks.	Folic Acid	13-19	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	Homo sapiens	228-232
12175915-1	2002	The human reduced folate carrier (RFC) is the major membrane transport system for both reduced folates and chemotherapeutic antifolate drugs, such as methotrexate (MTX).	Folic Acid	95-102	solute carrier family 19 member 1	Homo sapiens	10-32
12175915-1	2002	The human reduced folate carrier (RFC) is the major membrane transport system for both reduced folates and chemotherapeutic antifolate drugs, such as methotrexate (MTX).	Folic Acid	95-102	solute carrier family 19 member 1	Homo sapiens	34-37
12435857-2	2002	The gene associated with Rogers syndrome encodes for a plasma membrane thiamine transporter, THTR-1, a member of the solute carrier family that includes its homologue THTR-2 and the reduced folate carrier.	Folic Acid	190-196	solute carrier family 19 member 2	Homo sapiens	93-99
12011802-8	2002	Multiple regression analyses revealed that dementia severity was associated with an interaction between the TE2/(TE1+TE2) ratio and serum folate (B=4.59 (SE=1.48), beta=1.22, 95% C.I.=1.62-7.56, p<0.005).	Folic Acid	138-144	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	108-111
12011802-8	2002	Multiple regression analyses revealed that dementia severity was associated with an interaction between the TE2/(TE1+TE2) ratio and serum folate (B=4.59 (SE=1.48), beta=1.22, 95% C.I.=1.62-7.56, p<0.005).	Folic Acid	138-144	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	117-120
12133411-1	2002	OBJECTIVE: To investigate the relationship between pregnancy induced hypertension syndrome (PIH) and homocysteine, folic acid and vitamin B(12).	Folic Acid	115-125	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	92-95
11777509-8	2002	Women with low precounseling folate levels showed a highly significant mean increase in red cell folate from 475 nmol/L to 689 nmol/L 4 months after counseling.	Folic Acid	29-35	ribosomal protein L4	Homo sapiens	132-135
11777509-8	2002	Women with low precounseling folate levels showed a highly significant mean increase in red cell folate from 475 nmol/L to 689 nmol/L 4 months after counseling.	Folic Acid	97-103	ribosomal protein L4	Homo sapiens	132-135
12239739-13	2002	Decreases in NTD-specific IMRs may have been impacted by fortification of enriched grain products with folic acid since these efforts were optional beginning in 1996.	Folic Acid	103-113	fuzzy planar cell polarity protein	Homo sapiens	13-16
11755633-5	2001	Every doubling of serum folate concentration roughly halves the risk of an NTD.	Folic Acid	24-30	fuzzy planar cell polarity protein	Homo sapiens	75-78
11795438-0	2001	The effect of high doses of folic acid on the overexpression of ornithine decarboxylase and S-adenosylmethionine content in human colon adenomatous polyps.	Folic Acid	28-38	ornithine decarboxylase 1	Homo sapiens	64-87
11795438-1	2001	It was shown that the 3-month supplementation of patients having colon polyps with folic acid (5 mg/day) led to a 35% decrease in abnormally high ornithine decarboxylase activity in polyps that was accompanied by a 43% increase of S-adenosylmethionine content in polyps.	Folic Acid	83-93	ornithine decarboxylase 1	Homo sapiens	146-169
11731220-1	2001	Recently, a new family of facilitative carriers has been cloned consisting of the reduced folate (SLC19A1) and the thiamine (SLC19A2) transporters.	Folic Acid	90-96	solute carrier family 19 member 1	Homo sapiens	98-105
11731220-1	2001	Recently, a new family of facilitative carriers has been cloned consisting of the reduced folate (SLC19A1) and the thiamine (SLC19A2) transporters.	Folic Acid	90-96	solute carrier family 19 member 2	Homo sapiens	125-132
11577006-0	2001	COMT genotype, micronutrients in the folate metabolic pathway and breast cancer risk.	Folic Acid	37-43	catechol-O-methyltransferase	Homo sapiens	0-4
11577006-3	2001	Folate, whose intake levels have also been associated with breast cancer risk, and other micronutrients in the folate metabolic pathway influence levels of SAM and S-adenosylhomocysteine (SAH), a COMT inhibitor generated by the demethylation of SAM.	Folic Acid	0-6	catechol-O-methyltransferase	Homo sapiens	196-200
11577006-3	2001	Folate, whose intake levels have also been associated with breast cancer risk, and other micronutrients in the folate metabolic pathway influence levels of SAM and S-adenosylhomocysteine (SAH), a COMT inhibitor generated by the demethylation of SAM.	Folic Acid	111-117	catechol-O-methyltransferase	Homo sapiens	196-200
11585759-5	2001	In so doing, we show that MRP3 is not only active in the transport of MTX but is also active in the transport the physiological folates folic acid (FA) and N(5)-formyltetrahydrofolic acid (leucovorin) and that polyglutamylation of MTX abolishes transport.	Folic Acid	128-135	ATP binding cassette subfamily C member 3	Homo sapiens	26-30
11585759-5	2001	In so doing, we show that MRP3 is not only active in the transport of MTX but is also active in the transport the physiological folates folic acid (FA) and N(5)-formyltetrahydrofolic acid (leucovorin) and that polyglutamylation of MTX abolishes transport.	Folic Acid	136-146	ATP binding cassette subfamily C member 3	Homo sapiens	26-30
11585759-10	2001	The capacity of MRP3 to transport folates indicates that it may reduce intracellular levels of these compounds and thereby indirectly influence antifolate cytotoxicity, and it also implies that this pump may play a role in the response to chemotherapeutic regimens in which leucovorin is a component.	Folic Acid	34-41	ATP binding cassette subfamily C member 3	Homo sapiens	16-20
11290853-10	2001	CONCLUSIONS: Although our findings demonstrate different RFC transcript amounts and transport efficiencies among tissues, the present studies suggest that chronic ethanol exposure decreases the intestinal absorption of folic acid by altering the expression of RFC and consequently its transport kinetics in JBB.	Folic Acid	219-229	solute carrier family 19 member 1	Homo sapiens	260-263
11280750-11	2001	The localization of the human RFC to the mitochondrial membrane is a novel finding, and it suggests a role for the mitochondrial membrane in the transport of folates.	Folic Acid	158-165	solute carrier family 19 member 1	Homo sapiens	30-33
11166026-4	2001	Treatment of folate-replete or deficient WTK1 and TK6 cells with increasing concentrations (0-50microg/ml) of ethyl methanesulfonate (EMS) resulted in significantly different HPRT mutation dose-response relationships (P&lt;0.01), indicating that folate deficiency increased the EMS-induced mutant frequency in both cell lines, but with a greater effect in TK6 cells.	Folic Acid	13-19	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	175-179
14622275-2	2003	The gene associated with this disease encodes for thiamine transporter 1 (THTR1), a member of the SLC19 solute carrier family including THTR2 and the reduced folate carrier (RFC).	Folic Acid	158-164	solute carrier family 19 member 2	Homo sapiens	74-79
14608093-4	2003	The aim of this study was to investigate the bioaccessibility of folic acid and (6S)-5-methyltetrahydrofolate (5-CH3-H4folate) from fortified yogurt using a dynamic in vitro gastrointestinal model (TIM).	Folic Acid	65-75	Rho guanine nucleotide exchange factor 5	Homo sapiens	198-201
12749765-1	2003	The human reduced folate carrier (hRFC) mediates the transport of reduced folates and classical anti-folates into mammalian cells.	Folic Acid	18-24	solute carrier family 19 member 1	Homo sapiens	34-38
12749765-1	2003	The human reduced folate carrier (hRFC) mediates the transport of reduced folates and classical anti-folates into mammalian cells.	Folic Acid	74-81	solute carrier family 19 member 1	Homo sapiens	34-38
12749765-1	2003	The human reduced folate carrier (hRFC) mediates the transport of reduced folates and classical anti-folates into mammalian cells.	Folic Acid	101-108	solute carrier family 19 member 1	Homo sapiens	34-38
12867292-0	2003	The influence of iron, vitamin B(12), and folate levels on soluble transferrin receptor concentration in pregnant women.	Folic Acid	42-48	transferrin receptor	Homo sapiens	67-87
12887734-3	2003	Though reduced-folate carrier (RFC) is one of the major proteins mediating folate transport, knowledge of the developmental expression of RFC is lacking.	Folic Acid	15-21	solute carrier family 19 member 1	Homo sapiens	31-34
12749058-2	2003	Since genetic deficiencies in folate-dependent homocysteine metabolism have been identified in NTD families, we investigated a common variant in betaine-homocysteine methyltransferase (BHMT), 742G--&gt;A (R239Q), as a genetic modifier of NTD risk.	Folic Acid	30-36	betaine--homocysteine S-methyltransferase	Homo sapiens	145-183
12709672-11	2003	We found positive correlation between urine NAG activity and PGA.	Folic Acid	61-64	O-GlcNAcase	Homo sapiens	44-47
12628490-9	2003	These results suggest that down- and up-regulation of MRP1 (and MRP3) expression can influence cellular folate homeostasis, in particular when cellular retention by polyglutamylation of folates is attenuated.	Folic Acid	104-110	ATP binding cassette subfamily C member 3	Homo sapiens	64-68
12438316-1	2003	Serine hydroxymethyltransferase (SHMT; EC 2.1.2.1) catalyzes the reversible interconversion of serine and glycine with transfer of the serine side chain one-carbon group to tetrahydropteroylglutamate (H(4)PteGlu), and also the conversion of 5,10-methenyl-H(4)PteGlu to 5-formyl-H(4)PteGlu.	Folic Acid	205-211	serine hydroxymethyltransferase, cytosolic	Oryctolagus cuniculus	0-31
18414976-1	2009	In a previous publication we observed aberrant levels of the human reduced folate carrier (hRFC) in cortex from fetal Down syndrome (DS) subjects.	Folic Acid	75-81	solute carrier family 19 member 1	Homo sapiens	91-95
12438316-1	2003	Serine hydroxymethyltransferase (SHMT; EC 2.1.2.1) catalyzes the reversible interconversion of serine and glycine with transfer of the serine side chain one-carbon group to tetrahydropteroylglutamate (H(4)PteGlu), and also the conversion of 5,10-methenyl-H(4)PteGlu to 5-formyl-H(4)PteGlu.	Folic Acid	205-211	serine hydroxymethyltransferase, cytosolic	Oryctolagus cuniculus	33-37
12454742-9	2002	Collectively, the results demonstrate that expression of E45K hRFC leads to increased MTX resistance due to decreased membrane transport and, secondarily, from alterations in binding affinities and transport of folate substrates.	Folic Acid	211-217	solute carrier family 19 member 1	Homo sapiens	62-66
19019821-1	2009	The ubiquitously expressed reduced folate carrier (RFC) is the major transport system for folate cofactors in mammalian cells and tissues.	Folic Acid	35-41	solute carrier family 19 member 1	Homo sapiens	51-54
12228234-1	2002	Recently, our laboratory reported an intricate regulation of the human reduced folate carrier (hRFC) gene, involving multiple promoters and noncoding exons.	Folic Acid	79-85	solute carrier family 19 member 1	Homo sapiens	95-99
12228234-11	2002	Moreover, they document a functionally novel polymorphism that increases promoter activity and may contribute to interpatient variations in hRFC expression and effects on tissue folate homeostasis and antitumor response to antifolates.	Folic Acid	178-184	solute carrier family 19 member 1	Homo sapiens	140-144
19019821-2	2009	Previous considerations of RFC structure and mechanism were based on the notion that RFC monomers were sufficient to mediate transport of folate and antifolate substrates.	Folic Acid	138-144	solute carrier family 19 member 1	Homo sapiens	27-30
19019821-2	2009	Previous considerations of RFC structure and mechanism were based on the notion that RFC monomers were sufficient to mediate transport of folate and antifolate substrates.	Folic Acid	138-144	solute carrier family 19 member 1	Homo sapiens	85-88
19033438-2	2009	C1 tetrahydrofolate (THF) synthase, encoded by Mthfd1, is an entry point of 1Cs into folate metabolism through its formyl-THF synthetase (FTHFS) activity that catalyzes the ATP-dependent conversion of formate and THF to 10-formyl-THF.	Folic Acid	13-19	methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase	Mus musculus	47-53
12139489-11	2002	This constitutes the first demonstration of clustering of multiple human RFC mutations in TMD1, thereby suggesting that it plays a functional role in folate/antifolate binding and/or translocation.	Folic Acid	150-156	solute carrier family 19 member 1	Homo sapiens	73-76
19022216-1	2009	Methenyltetrahydrofolate synthetase (MTHFS) expression enhances folate-dependent de novo purine biosynthesis.	Folic Acid	18-24	methenyltetrahydrofolate synthetase	Homo sapiens	37-42
11923304-6	2002	However, when the MTHFS gene was disrupted in a strain lacking the de novo folate biosynthesis pathway, folinic acid (5-CHO-THF) could no longer support the folate requirement.	Folic Acid	75-81	methenyltetrahydrofolate synthetase	Homo sapiens	18-23
11923304-6	2002	However, when the MTHFS gene was disrupted in a strain lacking the de novo folate biosynthesis pathway, folinic acid (5-CHO-THF) could no longer support the folate requirement.	Folic Acid	157-163	methenyltetrahydrofolate synthetase	Homo sapiens	18-23
19852428-5	2009	Molecular analysis of 12 genetic polymorphisms involved in the folate metabolism revealed that the mother is heterozygous for the MTHFR C677T and TC2 A67G polymorphisms, and homozygous for the mutant MTRR A66G polymorphism.	Folic Acid	63-69	transcobalamin 2	Homo sapiens	146-149
11832423-2	2002	Wnt4 expression is induced throughout the collecting ducts in four murine models of renal injury that produce tubulointerstitial fibrosis: folic acid-induced nephropathy, unilateral ureteral obstruction, renal needle puncture, and genetic polycystic kidney disease.	Folic Acid	139-149	wingless-type MMTV integration site family, member 4	Mus musculus	0-4
18634013-2	2008	Foremost among these factors is the periconceptional use of supplementation containing folic acid, which is associated with a reduction in the risk of women having NTD-affected pregnancies.	Folic Acid	87-97	fuzzy planar cell polarity protein	Homo sapiens	164-167
12952083-2	2002	The calcium responses of vegetative cells to folate were dramatically impaired in Gbeta and Galpha4 null mutants but were restored with altered kinetics and temperature-sensitivity in Gbeta null mutants overexpressing wild type and temperature-sensitive Gbeta isoforms.	Folic Acid	45-51	succinate-CoA ligase GDP-forming subunit beta	Homo sapiens	82-87
12952083-2	2002	The calcium responses of vegetative cells to folate were dramatically impaired in Gbeta and Galpha4 null mutants but were restored with altered kinetics and temperature-sensitivity in Gbeta null mutants overexpressing wild type and temperature-sensitive Gbeta isoforms.	Folic Acid	45-51	succinate-CoA ligase GDP-forming subunit beta	Homo sapiens	184-189
12952083-2	2002	The calcium responses of vegetative cells to folate were dramatically impaired in Gbeta and Galpha4 null mutants but were restored with altered kinetics and temperature-sensitivity in Gbeta null mutants overexpressing wild type and temperature-sensitive Gbeta isoforms.	Folic Acid	45-51	succinate-CoA ligase GDP-forming subunit beta	Homo sapiens	184-189
11813127-2	2001	Periconceptional supplementation with multi-vitamins containing folic acid may normalize homocysteine metabolism and decrease the NTD risk.	Folic Acid	64-74	fuzzy planar cell polarity protein	Homo sapiens	130-133
18550330-6	2008	Complete protection against NTD was defined as RBC folate concentration above 900 nmol/L.	Folic Acid	51-57	fuzzy planar cell polarity protein	Homo sapiens	28-31
11705857-1	2001	The presence of sequence variants in the human reduced folate carrier (hRFC) was assessed in leukemia blasts from children with acute lymphoblastic leukemia (ALL) and in normal peripheral blood specimens.	Folic Acid	55-61	solute carrier family 19 member 1	Homo sapiens	71-75
18550330-7	2008	RESULTS: In 2006, 40% of the women of child-bearing age and 36% of pregnant women, exhibited RBC folate levels below 900 nmol/L, rendering them sub-optimally protected against NTD.	Folic Acid	97-103	fuzzy planar cell polarity protein	Homo sapiens	176-179
11568918-10	2001	The presence of both trisomy 21 and postclosure NTD in the same child supports the need for an extended periconceptional period of maternal folate supplementation to achieve greater preventive effects for both NTD and trisomy 21.	Folic Acid	140-146	fuzzy planar cell polarity protein	Homo sapiens	210-213
18187048-10	2008	The changes in CDX2 and CDX1 expression determined by methyl group deprivation may constitute one of the mechanisms sustaining the protective role attributed to folate in colon cancer.	Folic Acid	161-167	caudal type homeobox 1	Homo sapiens	24-28
11577006-9	2001	An increasing number of COMT(L) alleles was significantly associated with increased breast cancer risk in women with below median levels of folate (P(trend) = 0.05) or above median levels of homocysteine (P(trend) = 0.02).	Folic Acid	140-146	catechol-O-methyltransferase	Homo sapiens	24-28
11577006-10	2001	These findings are consistent with a role for certain folate pathway micronutrients in mediating the association between COMT genotype and breast cancer risk.	Folic Acid	54-60	catechol-O-methyltransferase	Homo sapiens	121-125
11585759-4	2001	Here we examine the role of MRP3 in these and related processes by determining the selectivity of this transporter for MTX, MTX polyglutamates, and physiological folates.	Folic Acid	162-169	ATP binding cassette subfamily C member 3	Homo sapiens	28-32
18525129-2	2008	In this pilot study, common variants of the apolipoprotein E (APOE) and HFE genes resulting in the iron overload disorder of hereditary hemochromatosis (C282Y, H63D and S65C) were evaluated as factors in sporadic AD in an Ontario sample in which folic acid fortification has been mandatory since 1998.	Folic Acid	246-256	homeostatic iron regulator	Homo sapiens	72-75
17681772-5	2008	With decreasing folate, the expression of both E-cadherin and SMAD-4 was decreased in NCM356.	Folic Acid	16-22	SMAD family member 4	Homo sapiens	62-68
11589473-5	2001	Furthermore it has been possible to show that the deconjugation of the folates by rat plasma conjugase was incomplete in foodstuffs whereas chicken pancreas conjugase effectively converted the different folate polyglutamates into folate diglutamates.	Folic Acid	71-78	gamma-glutamyl hydrolase	Rattus norvegicus	93-102
18400109-0	2008	Microarray analysis of E9.5 reduced folate carrier (RFC1; Slc19a1) knockout embryos reveals altered expression of genes in the cubilin-megalin multiligand endocytic receptor complex.	Folic Acid	36-42	solute carrier family 19 member 1	Homo sapiens	58-65
11589473-5	2001	Furthermore it has been possible to show that the deconjugation of the folates by rat plasma conjugase was incomplete in foodstuffs whereas chicken pancreas conjugase effectively converted the different folate polyglutamates into folate diglutamates.	Folic Acid	71-78	gamma-glutamyl hydrolase	Rattus norvegicus	157-166
18400109-0	2008	Microarray analysis of E9.5 reduced folate carrier (RFC1; Slc19a1) knockout embryos reveals altered expression of genes in the cubilin-megalin multiligand endocytic receptor complex.	Folic Acid	36-42	LDL receptor related protein 2	Homo sapiens	135-142
11410096-4	2001	OBJECTIVE: To evaluate the impact of food fortification with folic acid on NTD birth prevalence.	Folic Acid	61-71	fuzzy planar cell polarity protein	Homo sapiens	75-78
18400109-12	2008	CONCLUSION: Inactivation of RFC1 impacts the expression of several ligands and interacting proteins in the cubilin-amnionless-megalin complex that are involved in the maternal-fetal transport of folate and other nutrients, lipids and morphogens such as sonic hedgehog (Shh) and retinoids that play critical roles in normal embryogenesis.	Folic Acid	195-201	LDL receptor related protein 2	Homo sapiens	126-133
11410096-9	2001	CONCLUSIONS: A 19% reduction in NTD birth prevalence occurred following folic acid fortification of the US food supply.	Folic Acid	72-82	fuzzy planar cell polarity protein	Homo sapiens	32-35
18234954-8	2008	Similarly, in cisplatin-, folic acid-, and lipopolysaccharide-treated mice, urine netrin-1 excretion increased as early as 1 h and reached a peak level at 6 h after injection.	Folic Acid	26-36	netrin 1	Mus musculus	82-90
11284739-1	2001	GTP cyclohydrolase I (EC 3.5.4.16) is the first enzyme in the biosynthesis of tetrahydrobiopterin [(6R)-5,6,7,8-tetrahydro-L-biopterin, H(4)-biopterin] in mammals and of folic acid in bacteria.	Folic Acid	170-180	GTP cyclohydrolase 1	Homo sapiens	0-20
11284739-2	2001	Here we have characterized the GTP cyclohydrolase I gene structure and two mRNA species from Physarum polycephalum, an acellular slime mould that synthesizes H(4)-biopterin and metabolites of the folic acid biosynthetic pathway.	Folic Acid	196-206	GTP cyclohydrolase 1	Homo sapiens	31-51
11106643-1	2001	The relationship between loss of functional p53 and human reduced folate carrier (hRFC) levels and function was examined in REH lymphoblastic leukemia cells, which express wild type p53, and in p53-null K562 cells (K562(pTet-on/p53)) engineered to express wild type p53 under control of a tetracycline-inducible promoter.	Folic Acid	66-72	solute carrier family 19 member 1	Homo sapiens	82-86
19356074-2	2008	Here we report that folic acid treatment inhibited MTX induction of aryl sulfotransferase (AST-IV) in female rat liver and hydroxysteroid sulfotransferase (STa) in male rat liver.	Folic Acid	20-30	sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 2	Rattus norvegicus	123-154
11290853-2	2001	The reduced folate carrier (RFC) transports monoglutamyl folates across tissue membranes and could be affected by chronic exposure to ethanol.	Folic Acid	12-18	solute carrier family 19 member 1	Homo sapiens	28-31
11229418-0	2001	Homocysteine, fibrinogen, and lipoprotein(a) levels are simultaneously reduced in patients with chronic renal failure treated with folic acid, pyridoxine, and cyanocobalamin.	Folic Acid	131-141	lipoprotein(a)	Homo sapiens	30-44
11038362-1	2001	The thiamin transporter encoded by SLC19A2 and the reduced folate carrier (RFC1) share 40% homology at the protein level, but the thiamin transporter does not mediate transport of folates.	Folic Acid	59-65	solute carrier family 19 (thiamine transporter), member 2	Mus musculus	35-42
18235096-7	2008	After folic acid-induced acute kidney injury, fibroblast growth factor-inducible 14 expression increased in mouse tubular epithelium.	Folic Acid	6-16	DEAD box helicase 3, X-linked	Mus musculus	46-83
10978331-2	2000	The transduction of a human placental cDNA retroviral library into glyB cells, a Chinese hamster ovary K1 subline that is deficient in the transport of folates into mitochondria, resulted in the complementation of glycine auxotrophy of these cells.	Folic Acid	152-159	Glycine auxotroph B, complementation of hamster	Homo sapiens	67-71
18053808-4	2008	RESULTS: The non-wild type allele of SLC19A1 polymorphism -43T>C was associated with low red cell folate levels and the non-wild type allele of MTHFR polymorphism 677C>T with low plasma folate levels.	Folic Acid	98-104	solute carrier family 19 member 1	Homo sapiens	37-44
18053808-4	2008	RESULTS: The non-wild type allele of SLC19A1 polymorphism -43T>C was associated with low red cell folate levels and the non-wild type allele of MTHFR polymorphism 677C>T with low plasma folate levels.	Folic Acid	186-192	solute carrier family 19 member 1	Homo sapiens	37-44
18053808-5	2008	CONCLUSION: SLC19A1 and MTHFR genes are differently associated with red cell and plasma folate levels.	Folic Acid	88-94	solute carrier family 19 member 1	Homo sapiens	12-19
17720756-0	2007	Regulation of one-carbon metabolism in Arabidopsis: the N-terminal regulatory domain of cystathionine gamma-synthase is cleaved in response to folate starvation.	Folic Acid	143-149	Pyridoxal phosphate (PLP)-dependent transferases superfamily protein	Arabidopsis thaliana	88-116
17519396-1	2007	The folic acid analog methotrexate (MTX), a competitive inhibitor of dihydrofolate reductase (DHFR), is used to treat a variety of cancers and autoimmune disorders.	Folic Acid	4-14	Dihydrofolate reductase	Drosophila melanogaster	69-92
17519396-1	2007	The folic acid analog methotrexate (MTX), a competitive inhibitor of dihydrofolate reductase (DHFR), is used to treat a variety of cancers and autoimmune disorders.	Folic Acid	4-14	Dihydrofolate reductase	Drosophila melanogaster	94-98
17963270-3	2007	Numerous environmental and genetic influences contribute to NTD etiology; accumulating evidence from population-based studies has demonstrated that folate status is a significant determinant of NTD risk.	Folic Acid	148-154	fuzzy planar cell polarity protein	Homo sapiens	60-63
17963270-3	2007	Numerous environmental and genetic influences contribute to NTD etiology; accumulating evidence from population-based studies has demonstrated that folate status is a significant determinant of NTD risk.	Folic Acid	148-154	fuzzy planar cell polarity protein	Homo sapiens	194-197
17963270-8	2007	In this review, we summarize current research on the relationship between folate status and NTDs, with an emphasis on linking genetic variation, folate nutriture, and specific metabolic and/or genomic pathways that intersect to determine NTD outcomes.	Folic Acid	74-80	fuzzy planar cell polarity protein	Homo sapiens	92-95
17404734-1	2007	The reduced folate carrier (RFC) protein (SLC19A1-gene) has central role in the uptake and intracellular accumulation of folates.	Folic Acid	121-128	solute carrier family 19 member 1	Homo sapiens	4-40
17404734-1	2007	The reduced folate carrier (RFC) protein (SLC19A1-gene) has central role in the uptake and intracellular accumulation of folates.	Folic Acid	121-128	solute carrier family 19 member 1	Homo sapiens	42-49
17449573-0	2007	gamma-Glutamyl hydrolase, not glutamate carboxypeptidase II, hydrolyzes dietary folate in rat small intestine.	Folic Acid	80-86	gamma-glutamyl hydrolase	Rattus norvegicus	0-24
17449573-4	2007	We determined the respective roles of GCPII and gamma-GH in dietary folate hydrolysis in rat small intestine.	Folic Acid	68-74	gamma-glutamyl hydrolase	Rattus norvegicus	48-56
17449573-12	2007	gamma-GH folate hydrolase is abundant in rat postprandial pancreatic secretions and appears to hydrolyze dietary folates in the intestinal lumen prior to intestinal absorption.	Folic Acid	113-120	gamma-glutamyl hydrolase	Rattus norvegicus	0-8
17369066-0	2007	Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase.	Folic Acid	40-46	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Mus musculus	79-108
17448316-0	2007	[Folic acid antagonist methotrexate causes the development malformation of heart and down-regulates the BMP2b and HAS2 expressions in zebrafish].	Folic Acid	1-11	hyaluronan synthase 2	Danio rerio	114-118
17448316-11	2007	CONCLUSIONS: The inhibition of folic acid function may affect cardiac development of early embryos, resulting in a retardant development and a morphological abnormality of the heart in zebrafish, possibly by down-regulating the expressions of BMP2b and HAS2.	Folic Acid	31-41	hyaluronan synthase 2	Danio rerio	253-257
16962770-2	2006	Reduced folate carrier (RFC1, also named SLC19A1) is an essential folate transporter and functions as a bidirectional anion exchanger, taking up folate cofactors and exporting various organic anions.	Folic Acid	8-14	solute carrier family 19 member 1	Homo sapiens	41-48
16962770-2	2006	Reduced folate carrier (RFC1, also named SLC19A1) is an essential folate transporter and functions as a bidirectional anion exchanger, taking up folate cofactors and exporting various organic anions.	Folic Acid	66-72	solute carrier family 19 member 1	Homo sapiens	41-48
16997330-1	2006	We have studied the effect of genetic polymorphisms in the DNA repair genes hOGG1, XRCC1, XRCC3, ERCC2 and the MTHFR gene in the folate metabolism on the frequencies of cells with chromosomal aberrations (CA), chromosome-type aberrations (CSA), chromatid-type aberrations (CTA), chromatid breaks (CTB) and chromatid gaps (CTG) scored in peripheral blood lymphocytes from 651 Norwegian subjects of Caucasian descendant.	Folic Acid	129-135	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	239-242
22266439-7	2006	CONCLUSION: We concluded that folate deficiency, usage of drugs during pregnancy, and consanguineous marriage may play a role of predisposition to NTD.	Folic Acid	30-36	fuzzy planar cell polarity protein	Homo sapiens	147-150
16792574-4	2006	RESULTS: Ethanol feeding, folate deficiency, or their combination decreased liver and plasma glutathione and the activities of hepatic copper-zinc superoxide dismutase and glutathione peroxidase and increased the activity of manganese superoxide dismutase and glutathione reductase.	Folic Acid	26-32	glutathione-disulfide reductase	Homo sapiens	260-281
16760376-9	2006	Interaction between the structurally closely related, soluble folate-binding protein and megalin suggests that megalin plays an additional role in the uptake of folate bound to filtered folate-binding protein.	Folic Acid	62-68	LDL receptor related protein 2	Homo sapiens	89-96
16760376-9	2006	Interaction between the structurally closely related, soluble folate-binding protein and megalin suggests that megalin plays an additional role in the uptake of folate bound to filtered folate-binding protein.	Folic Acid	62-68	LDL receptor related protein 2	Homo sapiens	111-118
16760376-9	2006	Interaction between the structurally closely related, soluble folate-binding protein and megalin suggests that megalin plays an additional role in the uptake of folate bound to filtered folate-binding protein.	Folic Acid	161-167	LDL receptor related protein 2	Homo sapiens	89-96
16760376-9	2006	Interaction between the structurally closely related, soluble folate-binding protein and megalin suggests that megalin plays an additional role in the uptake of folate bound to filtered folate-binding protein.	Folic Acid	161-167	LDL receptor related protein 2	Homo sapiens	111-118
16760376-9	2006	Interaction between the structurally closely related, soluble folate-binding protein and megalin suggests that megalin plays an additional role in the uptake of folate bound to filtered folate-binding protein.	Folic Acid	161-167	LDL receptor related protein 2	Homo sapiens	89-96
16760376-9	2006	Interaction between the structurally closely related, soluble folate-binding protein and megalin suggests that megalin plays an additional role in the uptake of folate bound to filtered folate-binding protein.	Folic Acid	161-167	LDL receptor related protein 2	Homo sapiens	111-118
20641765-17	2004	One of the NIR dyes (NIR2) was conjugated to amino-derivatized folic acid to form NIR2-folate, which has an excitation maximum at 665 nm and an emission maximum at 686 nm.	Folic Acid	63-73	phosphatidylinositol transfer protein membrane associated 1	Homo sapiens	21-25
20641765-17	2004	One of the NIR dyes (NIR2) was conjugated to amino-derivatized folic acid to form NIR2-folate, which has an excitation maximum at 665 nm and an emission maximum at 686 nm.	Folic Acid	63-73	phosphatidylinositol transfer protein membrane associated 1	Homo sapiens	82-86
16368880-1	2006	The reduced folate carrier (RFC) is the dominant route for the uptake of various antifolates including PT523, a potent dihydrofolate reductase inhibitor (Ki = 0.35 pM) and an excellent transport substrate of the RFC (Kt = 0.7 microM).	Folic Acid	12-18	solute carrier family 19 member 1	Homo sapiens	28-31
16368880-1	2006	The reduced folate carrier (RFC) is the dominant route for the uptake of various antifolates including PT523, a potent dihydrofolate reductase inhibitor (Ki = 0.35 pM) and an excellent transport substrate of the RFC (Kt = 0.7 microM).	Folic Acid	12-18	solute carrier family 19 member 1	Homo sapiens	212-215
16470748-0	2006	Study of four genes belonging to the folate pathway: transcobalamin 2 is involved in the onset of non-syndromic cleft lip with or without cleft palate.	Folic Acid	37-43	transcobalamin 2	Homo sapiens	53-69
16505119-10	2006	Hence, loss of RFC function leads to collateral sensitivity to pemetrexed in HCT-15 cells, likely due to cellular folate pool contraction resulting in partial preservation of pemetrexed polyglutamylation and increased target enzyme inhibition.	Folic Acid	114-120	solute carrier family 19 member 1	Homo sapiens	15-18
16428507-1	2006	PURPOSE: The transcriptional regulation of the human reduced folate carrier (hRFC), involved in cellular uptake of methotrexate and reduced folates, was studied in childhood acute lymphoblastic leukemia (ALL).	Folic Acid	61-67	solute carrier family 19 member 1	Homo sapiens	77-81
16428507-1	2006	PURPOSE: The transcriptional regulation of the human reduced folate carrier (hRFC), involved in cellular uptake of methotrexate and reduced folates, was studied in childhood acute lymphoblastic leukemia (ALL).	Folic Acid	140-147	solute carrier family 19 member 1	Homo sapiens	77-81
16377938-0	2006	Effects of folic acid and magnesium on the production of homocysteine-induced extracellular matrix metalloproteinase-2 in cultured rat vascular smooth muscle cells.	Folic Acid	11-21	matrix metallopeptidase 2	Rattus norvegicus	92-118
16377938-2	2006	The aim of this study was to test whether homocysteine increases the production of matrix metalloproteinase-2 (MMP-2) and if extracellular additional magnesium and folic acid alters MMP-2 secretion.	Folic Acid	164-174	matrix metallopeptidase 2	Rattus norvegicus	182-187
16377938-5	2006	Increased production of MMP-2 induced by homocysteine was reduced by additional extracellular folic acid in a dose-dependent manner.	Folic Acid	94-104	matrix metallopeptidase 2	Rattus norvegicus	24-29
16377938-8	2006	Added extracellular folic acid and magnesium decreased the homocysteine-induced MMP-2 secretion.	Folic Acid	20-30	matrix metallopeptidase 2	Rattus norvegicus	80-85
16256389-2	2006	Previous studies using the Folr1 knockout mice revealed that maternal folate supplementation up-regulates the expression of the PCMT1 gene in Folr1 nullizygous neural tube tissue during neural tube closure.	Folic Acid	70-76	protein-L-isoaspartate (D-aspartate) O-methyltransferase 1	Mus musculus	128-133
16251605-8	2005	MAWDBP was simultaneously identified as a second spot with a lower isoelectric point (pI) that vanished almost completely after folate deficiency.	Folic Acid	128-134	phenazine biosynthesis-like protein domain containing 1	Rattus norvegicus	0-6
16195694-5	2005	Therefore, increasing the number of women who take dietary supplements containing 400 mug of folic acid daily remains an important component of NTD prevention.	Folic Acid	93-103	fuzzy planar cell polarity protein	Homo sapiens	144-147
15939798-2	2005	Mammalian cells are devoid of folate biosynthesis and are therefore folate auxotrophs that take up folate vitamins primarily via the reduced folate carrier (RFC).	Folic Acid	68-74	solute carrier family 19 member 1	Homo sapiens	133-155
15939798-2	2005	Mammalian cells are devoid of folate biosynthesis and are therefore folate auxotrophs that take up folate vitamins primarily via the reduced folate carrier (RFC).	Folic Acid	68-74	solute carrier family 19 member 1	Homo sapiens	157-160
15939798-2	2005	Mammalian cells are devoid of folate biosynthesis and are therefore folate auxotrophs that take up folate vitamins primarily via the reduced folate carrier (RFC).	Folic Acid	68-74	solute carrier family 19 member 1	Homo sapiens	133-155
15939798-2	2005	Mammalian cells are devoid of folate biosynthesis and are therefore folate auxotrophs that take up folate vitamins primarily via the reduced folate carrier (RFC).	Folic Acid	68-74	solute carrier family 19 member 1	Homo sapiens	157-160
16109384-0	2005	The relationship between folate transport activity at low pH and reduced folate carrier function in human Huh7 hepatoma cells.	Folic Acid	25-31	solute carrier family 19 member 1	Homo sapiens	65-87
16109384-7	2005	In Huh7 cells transiently transfected with an RFC siRNA, RFC expression was reduced by 60% resulting in a 40% decrease in MTX influx at pH 7.4 but only a very small (5%) reduction in MTX or folic acid influx at pH 5.5.	Folic Acid	190-200	solute carrier family 19 member 1	Homo sapiens	46-49
16109384-7	2005	In Huh7 cells transiently transfected with an RFC siRNA, RFC expression was reduced by 60% resulting in a 40% decrease in MTX influx at pH 7.4 but only a very small (5%) reduction in MTX or folic acid influx at pH 5.5.	Folic Acid	190-200	solute carrier family 19 member 1	Homo sapiens	57-60
15899835-0	2005	The human multidrug resistance protein MRP5 transports folates and can mediate cellular resistance against antifolates.	Folic Acid	55-62	ATP binding cassette subfamily C member 5	Homo sapiens	39-43
15899835-2	2005	Here we show that MRP5/ABCC5 is also an antifolate and folate exporter based on the following evidence: (a) Using membrane vesicles from HEK293 cells, we show that MRP5 transports both MTX (KM = 1.3 mmol/L and VMAX = 780 pmol per mg protein per minute) and folic acid (KM = 1.0 mmol/L and VMAX = 875 pmol per mg protein per minute).	Folic Acid	257-267	ATP binding cassette subfamily C member 5	Homo sapiens	18-22
15899835-2	2005	Here we show that MRP5/ABCC5 is also an antifolate and folate exporter based on the following evidence: (a) Using membrane vesicles from HEK293 cells, we show that MRP5 transports both MTX (KM = 1.3 mmol/L and VMAX = 780 pmol per mg protein per minute) and folic acid (KM = 1.0 mmol/L and VMAX = 875 pmol per mg protein per minute).	Folic Acid	257-267	ATP binding cassette subfamily C member 5	Homo sapiens	23-28
15834228-7	2005	RESULTS: : The relationship between alcohol drinking and serum folate concentration was significantly different between ALDH2 genotypes, indicating that the reduction of serum folate by alcohol drinking was more marked in men with ALDH2*1/2*2 than those with ALDH2*1/2*1.	Folic Acid	63-69	aldehyde dehydrogenase 2 family member	Homo sapiens	120-125
15834228-7	2005	RESULTS: : The relationship between alcohol drinking and serum folate concentration was significantly different between ALDH2 genotypes, indicating that the reduction of serum folate by alcohol drinking was more marked in men with ALDH2*1/2*2 than those with ALDH2*1/2*1.	Folic Acid	63-69	aldehyde dehydrogenase 2 family member	Homo sapiens	231-236
15834228-7	2005	RESULTS: : The relationship between alcohol drinking and serum folate concentration was significantly different between ALDH2 genotypes, indicating that the reduction of serum folate by alcohol drinking was more marked in men with ALDH2*1/2*2 than those with ALDH2*1/2*1.	Folic Acid	63-69	aldehyde dehydrogenase 2 family member	Homo sapiens	231-236
15834228-7	2005	RESULTS: : The relationship between alcohol drinking and serum folate concentration was significantly different between ALDH2 genotypes, indicating that the reduction of serum folate by alcohol drinking was more marked in men with ALDH2*1/2*2 than those with ALDH2*1/2*1.	Folic Acid	176-182	aldehyde dehydrogenase 2 family member	Homo sapiens	120-125
15834228-7	2005	RESULTS: : The relationship between alcohol drinking and serum folate concentration was significantly different between ALDH2 genotypes, indicating that the reduction of serum folate by alcohol drinking was more marked in men with ALDH2*1/2*2 than those with ALDH2*1/2*1.	Folic Acid	176-182	aldehyde dehydrogenase 2 family member	Homo sapiens	231-236
15834228-7	2005	RESULTS: : The relationship between alcohol drinking and serum folate concentration was significantly different between ALDH2 genotypes, indicating that the reduction of serum folate by alcohol drinking was more marked in men with ALDH2*1/2*2 than those with ALDH2*1/2*1.	Folic Acid	176-182	aldehyde dehydrogenase 2 family member	Homo sapiens	231-236
15340044-1	2004	The human reduced folate carrier (hRFC) is the dominant transporter for the uptake of antifolates used in cancer chemotherapy.	Folic Acid	18-24	solute carrier family 19 member 1	Homo sapiens	34-38
15337749-1	2004	Reduced folates such as 5-methyl tetrahydrofolate and classical antifolates such as methotrexate are actively transported into mammalian cells by the reduced folate carrier (RFC).	Folic Acid	8-15	solute carrier family 19 member 1	Homo sapiens	150-172
15337749-1	2004	Reduced folates such as 5-methyl tetrahydrofolate and classical antifolates such as methotrexate are actively transported into mammalian cells by the reduced folate carrier (RFC).	Folic Acid	8-15	solute carrier family 19 member 1	Homo sapiens	174-177
15531657-4	2004	The success of folic acid fortification in improving folate status and in reducing NTD rates is truly a public health triumph and provides a paradigm of collaboration between science and public health policy.	Folic Acid	15-25	fuzzy planar cell polarity protein	Homo sapiens	83-86
15564880-1	2004	We investigated whether polymorphisms in reduced folate carrier (SLC19A1 G80A) and gamma-glutamyl-hydrolase (GGH-401C/T) are predictive of methotrexate polyglutamate (MTXPG) levels in patients with rheumatoid arthritis treated with weekly low-dose methotrexate (MTX).	Folic Acid	49-55	solute carrier family 19 member 1	Homo sapiens	65-72
15371968-6	2004	Therefore, increasing the use of vitamins containing folic acid remains an important component of NTD prevention.	Folic Acid	53-63	fuzzy planar cell polarity protein	Homo sapiens	98-101
15203205-0	2004	Folate-sensitive fragile site FRA10A is due to an expansion of a CGG repeat in a novel gene, FRA10AC1, encoding a nuclear protein.	Folic Acid	0-6	fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2)	Homo sapiens	30-36
15203205-0	2004	Folate-sensitive fragile site FRA10A is due to an expansion of a CGG repeat in a novel gene, FRA10AC1, encoding a nuclear protein.	Folic Acid	0-6	FRA10A associated CGG repeat 1	Homo sapiens	93-101
15203205-2	2004	Expansion of CGG/CCG repeats has been shown to be the molecular basis of all five folate-sensitive fragile sites characterized molecularly so far, i.e., FRAXA, FRAXE, FRAXF, FRA11B, and FRA16A.	Folic Acid	82-88	fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)	Homo sapiens	153-158
15203205-3	2004	In the present study we have refined the localization of the FRA10A folate-sensitive fragile site by fluorescence in situ hybridization.	Folic Acid	68-74	fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2)	Homo sapiens	61-67
15203205-12	2004	We show that the expression of FRA10A, in parallel to the other cloned folate-sensitive fragile sites, is caused by an expansion and subsequent methylation of an unstable CGG trinucleotide repeat.	Folic Acid	71-77	fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2)	Homo sapiens	31-37
15203205-14	2004	Our data also suggest that in the heterozygous state FRA10A is likely a benign folate-sensitive fragile site.	Folic Acid	79-85	fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2)	Homo sapiens	53-59
15129193-8	2004	This decline in NTD-affected pregnancies highlights the partial success of the U.S. folic acid fortification program as a public health strategy.	Folic Acid	84-94	fuzzy planar cell polarity protein	Homo sapiens	16-19
15129193-9	2004	To reduce further the number of NTD-affected pregnancies, all women capable of becoming pregnant should follow the USPHS recommendation and consume 400 microg of folic acid every day.	Folic Acid	162-172	fuzzy planar cell polarity protein	Homo sapiens	32-35
15122759-4	2004	Ethanol feeding or folate deficiency, separately or in combination, decreased transcript levels of methylenetetrahydrofolate reductase (MTHFR), methionine adenosyltransferase (MAT1A), glycine-N-methyltransferase (GNMT) and S-adenosylhomocysteine hydrolase (SAHH).	Folic Acid	19-25	methionine adenosyltransferase 1A	Homo sapiens	176-181
15086930-1	2004	BACKGROUND: Controversy exists regarding the possible associations between a single nucleotide polymorphism of the transcobalamin II encoding gene (TCN2 776C&gt;G) and plasma levels of vitamin B(12), folate, or total homocysteine.	Folic Acid	200-206	transcobalamin 2	Homo sapiens	148-152
15338875-8	2004	It indicated that these compounds possibly inhibit dihydrofolate reductase (DHFR) or other enzymes on which folic acid depends.	Folic Acid	108-118	dihydrofolate reductase	Bos taurus	51-74
15338875-8	2004	It indicated that these compounds possibly inhibit dihydrofolate reductase (DHFR) or other enzymes on which folic acid depends.	Folic Acid	108-118	dihydrofolate reductase	Bos taurus	76-80
15066914-8	2004	We also observed that the positive association between the XRCC2 188His allele and breast cancer risk was only significant in women in the lowest plasma folate quartile (carriers versus non-carriers; multivariate odds ratio, 2.04; 95% confidence interval, 1.05-3.97), and this excess risk was abolished among those with higher plasma folate levels.	Folic Acid	153-159	X-ray repair cross complementing 2	Homo sapiens	59-64
15066914-8	2004	We also observed that the positive association between the XRCC2 188His allele and breast cancer risk was only significant in women in the lowest plasma folate quartile (carriers versus non-carriers; multivariate odds ratio, 2.04; 95% confidence interval, 1.05-3.97), and this excess risk was abolished among those with higher plasma folate levels.	Folic Acid	334-340	X-ray repair cross complementing 2	Homo sapiens	59-64
15066914-9	2004	Moreover, the inverse association between plasma folate level and breast cancer risk was stronger among XRCC2 188His carriers (P, trend = 0.004) than non-carriers (P, trend = 0.09).	Folic Acid	49-55	X-ray repair cross complementing 2	Homo sapiens	104-109
14767563-7	2004	On the basis of the modulation of COMT-mediated methylation of catecholamines, it is mechanistically explained that hyperhomocysteinemia would be a pathogenic factor in PD whereas vitamins B6, B12, and folate would be a protective factor.	Folic Acid	202-208	catechol-O-methyltransferase	Homo sapiens	34-38
14759604-4	2004	The results obtained suggest that the folate metabolism may be impaired by an increased degradation of DHFR, mediated by the 20S proteasome.	Folic Acid	38-44	dihydrofolate reductase	Bos taurus	103-107
14697491-7	2004	Dietary folic acid supplementation caused a significant decrease in the plasma homocysteine levels, a concomitant increase in the hyperhomocysteinemia-induced reduction in the cerebral eNOS and GLUT-1 expression levels, and a decrease in the hyperhomocysteinemia-induced VCAM-1 expression levels.	Folic Acid	8-18	solute carrier family 2 member 1	Rattus norvegicus	194-200
14697491-7	2004	Dietary folic acid supplementation caused a significant decrease in the plasma homocysteine levels, a concomitant increase in the hyperhomocysteinemia-induced reduction in the cerebral eNOS and GLUT-1 expression levels, and a decrease in the hyperhomocysteinemia-induced VCAM-1 expression levels.	Folic Acid	8-18	vascular cell adhesion molecule 1	Rattus norvegicus	271-277
14662146-0	2004	Effect of folic acid plus glycine supplement on uterine prostaglandin and endometrial granulocyte-macrophage colony-stimulating factor expression during early pregnancy in pigs.	Folic Acid	10-20	colony stimulating factor 2	Sus scrofa	86-134
14639706-5	2003	Here we assess possible interaction between the child"s TGFA TaqI A2A2 genotype and maternal cigarette smoking, alcohol consumption, use of multivitamins and folic acid.	Folic Acid	158-168	transforming growth factor alpha	Homo sapiens	56-60
14639706-10	2003	The risk associated with two copies of the A2 allele at TGFA TaqI was strong among children whose mothers did not use folic acid (relative risk=4.5, 95% confidence interval=1.3-15.7), and was only marginal among children whose mothers reported using folic acid (RR=1.4, 95% CI=0.2-12.7).	Folic Acid	118-128	transforming growth factor alpha	Homo sapiens	56-60
14639706-10	2003	The risk associated with two copies of the A2 allele at TGFA TaqI was strong among children whose mothers did not use folic acid (relative risk=4.5, 95% confidence interval=1.3-15.7), and was only marginal among children whose mothers reported using folic acid (RR=1.4, 95% CI=0.2-12.7).	Folic Acid	250-260	transforming growth factor alpha	Homo sapiens	56-60
14616766-2	2003	A large number of association studies have been conducted to investigate the possibility that NTD susceptibility is linked to polymorphic variation in genes involved in early embryonic development or in the absorption or metabolism of folate, a nutrient that has been clearly associated with a reduction in the risk of NTD pregnancy.	Folic Acid	235-241	fuzzy planar cell polarity protein	Homo sapiens	94-97
14616766-2	2003	A large number of association studies have been conducted to investigate the possibility that NTD susceptibility is linked to polymorphic variation in genes involved in early embryonic development or in the absorption or metabolism of folate, a nutrient that has been clearly associated with a reduction in the risk of NTD pregnancy.	Folic Acid	235-241	fuzzy planar cell polarity protein	Homo sapiens	319-322
12911562-6	2003	RESULTS: Holo-transcobalamin II levels were normal or supranormal in all patients and showed a linear association with albumin (r = 0.205, P = 0.025) and with vitamin B12 (r = 0.778, P = 0.001), but not with age, creatinine, body mass index, tHcy, ln-tHcy, vitamin B6, plasma folate, and red blood cell folate concentration.	Folic Acid	276-282	transcobalamin 2	Homo sapiens	14-31
12911562-6	2003	RESULTS: Holo-transcobalamin II levels were normal or supranormal in all patients and showed a linear association with albumin (r = 0.205, P = 0.025) and with vitamin B12 (r = 0.778, P = 0.001), but not with age, creatinine, body mass index, tHcy, ln-tHcy, vitamin B6, plasma folate, and red blood cell folate concentration.	Folic Acid	303-309	transcobalamin 2	Homo sapiens	14-31
12939425-4	2003	In CSF, the overall folate binding capacity by the two soluble folate-binding proteins FBP1 and FBP2 (sFBP) was measured using a radioligand binding method for H3-labeled folate.	Folic Acid	20-26	fructose-bisphosphatase 2	Homo sapiens	96-100
12939425-4	2003	In CSF, the overall folate binding capacity by the two soluble folate-binding proteins FBP1 and FBP2 (sFBP) was measured using a radioligand binding method for H3-labeled folate.	Folic Acid	63-69	fructose-bisphosphatase 2	Homo sapiens	96-100
12939425-4	2003	In CSF, the overall folate binding capacity by the two soluble folate-binding proteins FBP1 and FBP2 (sFBP) was measured using a radioligand binding method for H3-labeled folate.	Folic Acid	63-69	fructose-bisphosphatase 2	Homo sapiens	96-100
12757377-10	2003	Furthermore, tumor enhancement with the NIR2-folate probe persisted over 48 h and was inhibitable in vivo by administration of unlabeled folate.	Folic Acid	45-51	phosphatidylinositol transfer protein membrane associated 1	Homo sapiens	40-44
12628490-9	2003	These results suggest that down- and up-regulation of MRP1 (and MRP3) expression can influence cellular folate homeostasis, in particular when cellular retention by polyglutamylation of folates is attenuated.	Folic Acid	186-193	ATP binding cassette subfamily C member 3	Homo sapiens	64-68
15068242-4	2003	In conclusion, we suggest that aberrant hRFC expression may well have a role in the already observed deterioration of folate metabolism in DS.	Folic Acid	118-124	solute carrier family 19 member 1	Homo sapiens	40-44
12372420-2	2002	For the modification of folate by ONOO(-), folic acid was reacted with the combination of PMA activated PMN and PAPA NONOate or chemically synthesized ONOO(-).	Folic Acid	24-30	pappalysin 1	Homo sapiens	112-116
12372420-2	2002	For the modification of folate by ONOO(-), folic acid was reacted with the combination of PMA activated PMN and PAPA NONOate or chemically synthesized ONOO(-).	Folic Acid	43-53	pappalysin 1	Homo sapiens	112-116
12416030-0	2002	Severe folate restriction results in depletion of and alteration in the composition of the intracellular folate pool, moderate sensitization to methotrexate and trimetrexate, upregulation of endogenous DHFR activity, and overexpression of metallothionein II and folate receptor alpha that, upon folate repletion, confer drug resistance to CHL cells.	Folic Acid	7-13	dihydrofolate reductase	Cricetulus griseus	202-206
11997266-1	2002	Although the reduced folate carrier RFC1 and the thiamine transporters THTR-1 and THTR-2 share approximately 40% of their identity in protein sequence, RFC1 does not transport thiamine and THTR-1 and THTR-2 do not transport folates.	Folic Acid	21-27	solute carrier family 19 (thiamine transporter), member 2	Mus musculus	71-77
12545203-4	2002	Catecholamine depletion evoked by reserpine drastically decreases the folate-induced activity of S-adenosylmethionine decarboxylase (AdoMetDC), which limits polyamine biosynthesis, but has no effect on SSAT activity augmented by CB 3717.	Folic Acid	70-76	spermidine/spermine N1-acetyl transferase 1	Mus musculus	202-206
11100904-8	2000	The contrasting phenotypes of the Galpha mutants suggest the Galpha4 and Galpha5 subunits provide opposing functions in cell differentiation, localization, and chemotactic responses to folic acid.	Folic Acid	185-195	succinate-CoA ligase GDP/ADP-forming subunit alpha	Homo sapiens	34-40
10889164-0	2000	Effects of dietary folate on DNA strand breaks within mutation-prone exons of the p53 gene in rat colon.	Folic Acid	19-25	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	82-85
11005799-11	2000	Human NAT1 and its murine equivalent specifically acetylate the folate catabolite p-aminobenzoylglutamate.	Folic Acid	64-70	N-acetyltransferase 1	Homo sapiens	6-10
11183038-0	2000	Folate in CSF and age.	Folic Acid	0-6	colony stimulating factor 2	Homo sapiens	10-13
10993224-8	2000	These results demonstrate that the potent inhibitory activities of N(omega)-masked ornithine analogs against the growth of Meth A cells and methotrexate-resistant CCRF-CEM cells, results from effective uptake via reduced folate carrier and their potent DHFR inhibition.	Folic Acid	221-227	dihydrofolate reductase	Homo sapiens	253-257
11034814-6	2000	The new fluoro-pyrimidines and TS inhibitors are important classes of drug which have been designed to take advantage of the knowledge of folate metabolism gained from basic clinical research.	Folic Acid	138-144	thymidylate synthetase	Homo sapiens	31-33
10787414-1	2000	The differential polarized distribution of the reduced- folate transporter (RFT-1) and folate receptor alpha (FRalpha), the two proteins involved in the transport of folate, has been characterized in normal mouse retinal pigment epithelium (RPE) and in cultured human RPE cells.	Folic Acid	56-62	RFT1 homolog	Mus musculus	76-81
10766749-8	2000	The effect of mimosine on folate metabolism is associated with decreased cytoplasmic serine hydroxymethyltransferase (cSHMT) expression in MCF-7 cells but not in SH-SY5Y cells.	Folic Acid	26-32	serine hydroxymethyltransferase 1	Homo sapiens	73-116
10766749-8	2000	The effect of mimosine on folate metabolism is associated with decreased cytoplasmic serine hydroxymethyltransferase (cSHMT) expression in MCF-7 cells but not in SH-SY5Y cells.	Folic Acid	26-32	serine hydroxymethyltransferase 1	Homo sapiens	118-123
10767335-8	2000	In view of the role of folate in protecting against neural tube defects, we propose that NAT1 is a candidate risk factor for susceptibility to neural tube defects.	Folic Acid	23-29	N-acetyltransferase 1	Homo sapiens	89-93
10699949-10	2000	The reduced level of FRalpha in SKOV-CBZ clones was associated with a decreased binding capacity of folic acid.	Folic Acid	100-110	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	21-28
10739874-1	2000	N(alpha)-(4-Amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-o rnithine (PT523) is an unusually tight-binding dihydrofolate reductase (DHFR) inhibitor and is efficiently taken up into cells via the reduced folate carrier (RFC).	Folic Acid	115-121	dihydrofolate reductase	Homo sapiens	133-137
10739875-2	2000	gamma-Glutamyl hydrolase (GH, EC 3.4.19.9) is a lysosomal and secreted glycoprotein that hydrolyzes the gamma-glutamyl tail of antifolate and folate polyglutamates.	Folic Acid	131-137	gamma-glutamyl hydrolase	Homo sapiens	0-24
10739875-2	2000	gamma-Glutamyl hydrolase (GH, EC 3.4.19.9) is a lysosomal and secreted glycoprotein that hydrolyzes the gamma-glutamyl tail of antifolate and folate polyglutamates.	Folic Acid	131-137	gamma-glutamyl hydrolase	Homo sapiens	26-28
10683342-7	2000	KSHV-DHFR was inhibited by folate antagonists such as methotrexate (K(i): 200 pM), aminopterin (K(i): 610 pM), pyrimethamine (K(i): 29 nM), trimethoprim (K(i): 2.3 microM), and piritrexim (K(i): 3.9 nM).	Folic Acid	27-33	dihydrofolate reductase	Homo sapiens	5-9
10683342-8	2000	In all cases, K(i) values for these folate antagonists were higher for KSHV-DHFR than for rhDHFR.	Folic Acid	36-42	dihydrofolate reductase	Homo sapiens	76-80
10527932-1	1999	Gamma-glutamyl hydrolase (GH), which hydrolyses the gamma-glutamyl conjugates of folic acid, is a key enzyme in the maintenance of cellular folylpolyglutamate concentrations.	Folic Acid	81-91	gamma-glutamyl hydrolase	Homo sapiens	0-24
10527932-1	1999	Gamma-glutamyl hydrolase (GH), which hydrolyses the gamma-glutamyl conjugates of folic acid, is a key enzyme in the maintenance of cellular folylpolyglutamate concentrations.	Folic Acid	81-91	gamma-glutamyl hydrolase	Homo sapiens	26-28
10508523-0	1999	Mice lacking the folic acid-binding protein Folbp1 are defective in early embryonic development.	Folic Acid	17-27	folate receptor 1 (adult)	Mus musculus	44-50
10508523-3	1999	Previous experiments have identified a folate-binding protein (Folbp1) that functions as a membrane receptor to mediate the high-affinity internalization and delivery of folate to the cytoplasm of the cell.	Folic Acid	39-45	folate receptor 1 (adult)	Mus musculus	63-69
10508523-6	1999	To determine whether Folbp1 is involved in maternal-to-fetal folate transport, we inactivated Folbp1 in mice.	Folic Acid	61-67	folate receptor 1 (adult)	Mus musculus	21-27
10508523-10	1999	Our results suggest that Folbp1 has a critical role in folate homeostasis during development, and that functional defects in the human homologue (FOLR1) of Folbp1 may contribute to similar defects in humans.	Folic Acid	55-61	folate receptor 1 (adult)	Mus musculus	25-31
10508523-10	1999	Our results suggest that Folbp1 has a critical role in folate homeostasis during development, and that functional defects in the human homologue (FOLR1) of Folbp1 may contribute to similar defects in humans.	Folic Acid	55-61	folate receptor alpha	Homo sapiens	146-151
10508523-10	1999	Our results suggest that Folbp1 has a critical role in folate homeostasis during development, and that functional defects in the human homologue (FOLR1) of Folbp1 may contribute to similar defects in humans.	Folic Acid	55-61	folate receptor 1 (adult)	Mus musculus	156-162
10545786-3	1999	TS has been used as a target for cancer chemotherapy in the development of fluoropyrimidines such as 5-fluorouracil (5FU) and 5-fluorodeoxyuridine and novel folate-based TS inhibitors such as ZD1694 (Tomudex, Raltitrexed), LY231514, AG337 (Thymitaq) and GW1843U89.	Folic Acid	157-163	thymidylate synthetase	Homo sapiens	0-2
10545786-3	1999	TS has been used as a target for cancer chemotherapy in the development of fluoropyrimidines such as 5-fluorouracil (5FU) and 5-fluorodeoxyuridine and novel folate-based TS inhibitors such as ZD1694 (Tomudex, Raltitrexed), LY231514, AG337 (Thymitaq) and GW1843U89.	Folic Acid	157-163	thymidylate synthetase	Homo sapiens	170-172
10449621-6	1999	The findings show that TCR/RAG mice (i) accepted transplants of human tumors, including the folate-receptor-positive tumor line KB; (ii) contained endogenous cytotoxic T lymphocytes that could be activated in vivo with an antigenic peptide recognized by the transgenic TCR; (iii) rejected human tumors after treatment with the activating peptide and bispecific agents that contained folic acid co-valently linked to an anti-TCR antibody.	Folic Acid	383-393	T cell receptor alpha variable 6-3	Mus musculus	23-26
10449621-7	1999	Successful rejection was achieved with folate conjugates of Fab or scFv fragments.	Folic Acid	39-45	FA complementation group B	Homo sapiens	60-63
10375617-1	1999	Decreased reduced folate carrier (RFC) activity has been associated with MTX resistance in experimental models of transport-mediated MTX resistance, and has been attributed to changes in the expression of RFC1, the gene that encodes a protein with this activity.	Folic Acid	18-24	metaxin 1	Homo sapiens	73-76
10375617-1	1999	Decreased reduced folate carrier (RFC) activity has been associated with MTX resistance in experimental models of transport-mediated MTX resistance, and has been attributed to changes in the expression of RFC1, the gene that encodes a protein with this activity.	Folic Acid	18-24	metaxin 1	Homo sapiens	133-136
10340592-6	1999	The [3H]folic acid and FBP peaks coincided, indicating that the RIA is specific for FBP.	Folic Acid	8-18	folate receptor alpha	Homo sapiens	84-87
10598551-1	1999	Folylpoly-gamma-glutamate synthetase (FPGS) catalyzes the addition of several equivalents of glutamic acid to the gamma-carboxyl group in the side chain of folate cofactors and analogs.	Folic Acid	156-162	folylpolyglutamate synthase	Homo sapiens	0-36
10598551-1	1999	Folylpoly-gamma-glutamate synthetase (FPGS) catalyzes the addition of several equivalents of glutamic acid to the gamma-carboxyl group in the side chain of folate cofactors and analogs.	Folic Acid	156-162	folylpolyglutamate synthase	Homo sapiens	38-42
10598551-2	1999	Folylpoly-gamma-glutamate synthetase has three functions in folate homeostasis in mammals: polyglutamation prevents efflux of folate cofactors from the cell, it increases the binding of folate cofactors to some of the enzymes of folate interconversion and biosynthesis, and it appears to allow the accumulation of folates in the mitochondria that are required for glycine synthesis.	Folic Acid	60-66	folylpolyglutamate synthase	Homo sapiens	0-36
10598551-2	1999	Folylpoly-gamma-glutamate synthetase has three functions in folate homeostasis in mammals: polyglutamation prevents efflux of folate cofactors from the cell, it increases the binding of folate cofactors to some of the enzymes of folate interconversion and biosynthesis, and it appears to allow the accumulation of folates in the mitochondria that are required for glycine synthesis.	Folic Acid	126-132	folylpolyglutamate synthase	Homo sapiens	0-36
10598551-2	1999	Folylpoly-gamma-glutamate synthetase has three functions in folate homeostasis in mammals: polyglutamation prevents efflux of folate cofactors from the cell, it increases the binding of folate cofactors to some of the enzymes of folate interconversion and biosynthesis, and it appears to allow the accumulation of folates in the mitochondria that are required for glycine synthesis.	Folic Acid	126-132	folylpolyglutamate synthase	Homo sapiens	0-36
10598551-2	1999	Folylpoly-gamma-glutamate synthetase has three functions in folate homeostasis in mammals: polyglutamation prevents efflux of folate cofactors from the cell, it increases the binding of folate cofactors to some of the enzymes of folate interconversion and biosynthesis, and it appears to allow the accumulation of folates in the mitochondria that are required for glycine synthesis.	Folic Acid	314-321	folylpolyglutamate synthase	Homo sapiens	0-36
10598551-6	1999	The cytotoxicity of both thymidylate synthase and purine inhibitors requires continued inhibition of target for greater than one generation time, so that the integrative function of FPGS adds considerably to the efficiency of folate antimetabolites.	Folic Acid	226-232	thymidylate synthetase	Homo sapiens	25-45
10598551-6	1999	The cytotoxicity of both thymidylate synthase and purine inhibitors requires continued inhibition of target for greater than one generation time, so that the integrative function of FPGS adds considerably to the efficiency of folate antimetabolites.	Folic Acid	226-232	folylpolyglutamate synthase	Homo sapiens	182-186
10094554-1	1999	FRAXA, FRAXE, and FRAXF are folate-sensitive fragile sites originally discovered in patients with X-linked mental retardation.	Folic Acid	28-34	fragile site, folic acid type, rare, fra(X)(q28) E	Homo sapiens	7-12
9679969-8	1998	Thus, the ideal requirement for the folic acid-enhanced synergy is that a nonpolyglutamylatable DHFR inhibitor be combined with a polyglutamylatable inhibitor of another folate-requiring enzyme.	Folic Acid	36-46	dihydrofolate reductase	Homo sapiens	96-100
9679969-9	1998	A hypothesis to explain this general phenomenon involves the critical role of folylpoly-gamma-glutamate synthetase and the effect of the DHFR inhibitor in decreasing the protection by folic acid of cells to the other antifolates.	Folic Acid	184-194	folylpolyglutamate synthase	Homo sapiens	78-114
9679969-9	1998	A hypothesis to explain this general phenomenon involves the critical role of folylpoly-gamma-glutamate synthetase and the effect of the DHFR inhibitor in decreasing the protection by folic acid of cells to the other antifolates.	Folic Acid	184-194	dihydrofolate reductase	Homo sapiens	137-141
9714324-1	1998	The effect of down-regulation of folylpoly-gamma-glutamate synthetase (FPGS) activity on intracellular reduced folate accumulation and cellular proliferation was examined, using an inducible antisense expression system in the human T-lymphoblastic leukemia cell line CCRF-CEM.	Folic Acid	111-117	folylpolyglutamate synthase	Homo sapiens	33-69
9714324-1	1998	The effect of down-regulation of folylpoly-gamma-glutamate synthetase (FPGS) activity on intracellular reduced folate accumulation and cellular proliferation was examined, using an inducible antisense expression system in the human T-lymphoblastic leukemia cell line CCRF-CEM.	Folic Acid	111-117	folylpolyglutamate synthase	Homo sapiens	71-75
9714324-2	1998	FPGS catalyzes the addition of gamma-glutamyl residues to natural folates and classical antifolates, which results in their enhanced cellular retention and increased cytotoxicity.	Folic Acid	66-73	folylpolyglutamate synthase	Homo sapiens	0-4
9714324-6	1998	This inducible expression system was used to demonstrate that lower FPGS activity can lead to substantially lower intracellular folate content, which coincides with suppression of thymidylate synthesis and inhibition of cellular proliferation.	Folic Acid	128-134	folylpolyglutamate synthase	Homo sapiens	68-72
9742457-2	1998	Trienzyme treatment is performed by using alpha-amylase and protease for folate extraction from carbohydrate and protein matrices, and folate conjugase for the hydrolysis of polyglutamyl folates.	Folic Acid	73-79	alpha amylase	Bos taurus	42-55
9462523-0	1998	5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia.	Folic Acid	45-55	low density lipoprotein receptor	Homo sapiens	90-119
9462523-11	1998	CONCLUSIONS: These results show that the active form of folic acid restores in vivo endothelial function in FH.	Folic Acid	56-66	low density lipoprotein receptor	Homo sapiens	108-110
9426700-5	1998	FR-alpha mRNA expression in the cell lines was in good agreement with the corresponding protein expression evaluated by cellular folic acid binding and immunofluorescence analysis, using a specific monoclonal antibody (MAb) (MOv18).	Folic Acid	129-139	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	0-8
9426700-10	1998	Treatment with the N-hydroxysuccinimide of folic acid, which blocks FR-alpha activity, showed only a partial inhibition (about 20%) of folate internalization in all the cell lines.	Folic Acid	43-53	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	68-76
9762364-1	1998	Chemotherapeutic drugs targeted at folate-dependent reactions have typically been directed at a limited number of target enzymes: dihydrofolate reductase, thymidylate synthase, and GAR and AICAR transformylase.	Folic Acid	35-41	dihydrofolate reductase	Homo sapiens	130-153
9762364-1	1998	Chemotherapeutic drugs targeted at folate-dependent reactions have typically been directed at a limited number of target enzymes: dihydrofolate reductase, thymidylate synthase, and GAR and AICAR transformylase.	Folic Acid	35-41	thymidylate synthetase	Homo sapiens	155-175
9619760-1	1998	PURPOSE: Tomudex is a second-generation folate analogue that when polyglutamated is a potent inhibitor of thymidylate synthase (TS).	Folic Acid	40-46	thymidylate synthetase	Homo sapiens	106-126
9619760-1	1998	PURPOSE: Tomudex is a second-generation folate analogue that when polyglutamated is a potent inhibitor of thymidylate synthase (TS).	Folic Acid	40-46	thymidylate synthetase	Homo sapiens	128-130
9488247-8	1998	We propose that infants with mutations in the folate receptor alpha gene might be at increased risk for congenital anomalies due to a reduced binding affinity for 5-methyltetrahydrofolate, the physiologic form of folic acid.	Folic Acid	213-223	folate receptor alpha	Homo sapiens	46-67
9420019-5	1997	During the past 50 years, many of the enzymes requiring folate as a co-factor (ie, thymidylate synthase), and molecules critical in folate homeostasis (ie, the reduced folate carrier, folylpolyglutamate synthase), have been purified and even crystallized.	Folic Acid	56-62	thymidylate synthetase	Homo sapiens	83-103
9295311-14	1997	Folic acid, a chemoattractant in the vegetative cells that enables amoebae to find bacteria in the wild, also triggers the activation of adenylyl cyclase, which is impaired in the vegetative cells lacking the Galpha protein subunit Galpha4 (Hadwiger, J., Lee, S., and Firtel, R. (1994) Proc.	Folic Acid	0-10	succinate-CoA ligase GDP/ADP-forming subunit alpha	Homo sapiens	209-215
9295311-21	1997	Maximum levels of folate-stimulated ERK2 activity occur in cells from very early in development, prior to aggregation, and again at the tipped aggregate stages, corresponding to the stages in which folate receptors and the coupled Galpha subunit Galpha4 are maximally expressed.	Folic Acid	18-24	succinate-CoA ligase GDP/ADP-forming subunit alpha	Homo sapiens	231-237
9301457-1	1997	The major role of the high-affinity folate-binding protein (FBP) is to regulate cellular folate homeostasis by increasing folate uptake in case of extracellular and intracellular folate deficiency.	Folic Acid	36-42	folate receptor alpha	Homo sapiens	60-63
9301457-1	1997	The major role of the high-affinity folate-binding protein (FBP) is to regulate cellular folate homeostasis by increasing folate uptake in case of extracellular and intracellular folate deficiency.	Folic Acid	89-95	folate receptor alpha	Homo sapiens	36-58
9301457-1	1997	The major role of the high-affinity folate-binding protein (FBP) is to regulate cellular folate homeostasis by increasing folate uptake in case of extracellular and intracellular folate deficiency.	Folic Acid	89-95	folate receptor alpha	Homo sapiens	60-63
9301457-1	1997	The major role of the high-affinity folate-binding protein (FBP) is to regulate cellular folate homeostasis by increasing folate uptake in case of extracellular and intracellular folate deficiency.	Folic Acid	89-95	folate receptor alpha	Homo sapiens	36-58
9301457-1	1997	The major role of the high-affinity folate-binding protein (FBP) is to regulate cellular folate homeostasis by increasing folate uptake in case of extracellular and intracellular folate deficiency.	Folic Acid	89-95	folate receptor alpha	Homo sapiens	60-63
9301457-10	1997	This suggests a possible association between FBP overexpression and a biochemical defect of the cellular folate metabolism involved in the methionine cycle.	Folic Acid	105-111	folate receptor alpha	Homo sapiens	45-48
9267842-6	1997	In an alternative approach to the generation of a targeted adenoviral vector, we conjugated folate to the neutralising Fab fragment of an anti-fibre monoclonal antibody.	Folic Acid	92-98	FA complementation group B	Homo sapiens	119-122
9192787-3	1997	Our previous studies showed that, after 20 to 32 hours of culture in folate-deficient medium with 4 U/mL of erythropoietin, the folate-deficient proerythroblasts underwent apoptosis, whereas control erythroblasts survived and differentiated into reticulocytes over a period of 48 hours.	Folic Acid	69-75	erythropoietin	Mus musculus	108-122
9192787-7	1997	Folate-deficient erythroblasts cultured in folate-deficient medium had marked decreases in all coenzyme forms of folate that persisted throughout culture, increased uracil misincorporation into DNA, persistent accumulations of p53 and p21, and decreased reticulocyte production but increased size of individual reticulocytes.	Folic Acid	0-6	transformation related protein 53, pseudogene	Mus musculus	227-230
9192787-7	1997	Folate-deficient erythroblasts cultured in folate-deficient medium had marked decreases in all coenzyme forms of folate that persisted throughout culture, increased uracil misincorporation into DNA, persistent accumulations of p53 and p21, and decreased reticulocyte production but increased size of individual reticulocytes.	Folic Acid	43-49	transformation related protein 53, pseudogene	Mus musculus	227-230
9187658-4	1997	The site of action is the de novo folate biosynthesis enzyme dihydropteroate synthase (DHPS) where sulfonamides act as analogues of one of the substrates, para-aminobenzoic acid (pABA).	Folic Acid	34-40	Dihydropteroate synthase	Escherichia coli	61-85
9187658-4	1997	The site of action is the de novo folate biosynthesis enzyme dihydropteroate synthase (DHPS) where sulfonamides act as analogues of one of the substrates, para-aminobenzoic acid (pABA).	Folic Acid	34-40	Dihydropteroate synthase	Escherichia coli	87-91
9147608-0	1997	Folate-based thymidylate synthase inhibitors in cancer chemotherapy.	Folic Acid	0-6	thymidylate synthetase	Homo sapiens	13-33
9147608-1	1997	Understanding the relationship between chemical structure and biological properties of folate analogs, particularly their interactions with the target enzymes, transport proteins and folate-metabolizing enzyme, folylpolyglutamate synthetase (FPGS), has enabled the rational design and development of the selective thymidylate synthase (TS) inhibitors with folate-based structures for clinical uses.	Folic Acid	87-93	folylpolyglutamate synthase	Homo sapiens	211-240
9147608-1	1997	Understanding the relationship between chemical structure and biological properties of folate analogs, particularly their interactions with the target enzymes, transport proteins and folate-metabolizing enzyme, folylpolyglutamate synthetase (FPGS), has enabled the rational design and development of the selective thymidylate synthase (TS) inhibitors with folate-based structures for clinical uses.	Folic Acid	87-93	folylpolyglutamate synthase	Homo sapiens	242-246
9147608-1	1997	Understanding the relationship between chemical structure and biological properties of folate analogs, particularly their interactions with the target enzymes, transport proteins and folate-metabolizing enzyme, folylpolyglutamate synthetase (FPGS), has enabled the rational design and development of the selective thymidylate synthase (TS) inhibitors with folate-based structures for clinical uses.	Folic Acid	87-93	thymidylate synthetase	Homo sapiens	314-334
9147608-1	1997	Understanding the relationship between chemical structure and biological properties of folate analogs, particularly their interactions with the target enzymes, transport proteins and folate-metabolizing enzyme, folylpolyglutamate synthetase (FPGS), has enabled the rational design and development of the selective thymidylate synthase (TS) inhibitors with folate-based structures for clinical uses.	Folic Acid	183-189	folylpolyglutamate synthase	Homo sapiens	211-240
9147608-1	1997	Understanding the relationship between chemical structure and biological properties of folate analogs, particularly their interactions with the target enzymes, transport proteins and folate-metabolizing enzyme, folylpolyglutamate synthetase (FPGS), has enabled the rational design and development of the selective thymidylate synthase (TS) inhibitors with folate-based structures for clinical uses.	Folic Acid	183-189	folylpolyglutamate synthase	Homo sapiens	242-246
9147608-1	1997	Understanding the relationship between chemical structure and biological properties of folate analogs, particularly their interactions with the target enzymes, transport proteins and folate-metabolizing enzyme, folylpolyglutamate synthetase (FPGS), has enabled the rational design and development of the selective thymidylate synthase (TS) inhibitors with folate-based structures for clinical uses.	Folic Acid	183-189	folylpolyglutamate synthase	Homo sapiens	211-240
9147608-1	1997	Understanding the relationship between chemical structure and biological properties of folate analogs, particularly their interactions with the target enzymes, transport proteins and folate-metabolizing enzyme, folylpolyglutamate synthetase (FPGS), has enabled the rational design and development of the selective thymidylate synthase (TS) inhibitors with folate-based structures for clinical uses.	Folic Acid	183-189	folylpolyglutamate synthase	Homo sapiens	242-246
9099956-1	1997	The high-affinity folate-binding protein (FBP) is primarily involved in the uptake of the 5-methyltetrahydrofolate, and its expression may be physiologically regulated by the intracellular folate content.	Folic Acid	18-24	folate receptor beta	Homo sapiens	42-45
9099956-2	1997	The overexpression of FBP on the cell surface of ovarian carcinoma cells may be responsible for an increased folate uptake.	Folic Acid	109-115	folate receptor beta	Homo sapiens	22-25
8863812-1	1996	Folypolyglutamate synthetase (FPGS) is responsible for the conversion of naturally occurring folates and antifolates to their poly-gama-glutamyl derivatives, which are the forms required for intracellular retention of folates and are also the preferred substrates (cofactors) for most folate-dependent enzymes.	Folic Acid	93-100	folylpolyglutamyl synthetase	Mus musculus	0-28
8863812-1	1996	Folypolyglutamate synthetase (FPGS) is responsible for the conversion of naturally occurring folates and antifolates to their poly-gama-glutamyl derivatives, which are the forms required for intracellular retention of folates and are also the preferred substrates (cofactors) for most folate-dependent enzymes.	Folic Acid	93-100	folylpolyglutamyl synthetase	Mus musculus	30-34
8863812-1	1996	Folypolyglutamate synthetase (FPGS) is responsible for the conversion of naturally occurring folates and antifolates to their poly-gama-glutamyl derivatives, which are the forms required for intracellular retention of folates and are also the preferred substrates (cofactors) for most folate-dependent enzymes.	Folic Acid	109-116	folylpolyglutamyl synthetase	Mus musculus	0-28
8863812-1	1996	Folypolyglutamate synthetase (FPGS) is responsible for the conversion of naturally occurring folates and antifolates to their poly-gama-glutamyl derivatives, which are the forms required for intracellular retention of folates and are also the preferred substrates (cofactors) for most folate-dependent enzymes.	Folic Acid	109-116	folylpolyglutamyl synthetase	Mus musculus	30-34
8863812-1	1996	Folypolyglutamate synthetase (FPGS) is responsible for the conversion of naturally occurring folates and antifolates to their poly-gama-glutamyl derivatives, which are the forms required for intracellular retention of folates and are also the preferred substrates (cofactors) for most folate-dependent enzymes.	Folic Acid	93-99	folylpolyglutamyl synthetase	Mus musculus	0-28
8863812-1	1996	Folypolyglutamate synthetase (FPGS) is responsible for the conversion of naturally occurring folates and antifolates to their poly-gama-glutamyl derivatives, which are the forms required for intracellular retention of folates and are also the preferred substrates (cofactors) for most folate-dependent enzymes.	Folic Acid	93-99	folylpolyglutamyl synthetase	Mus musculus	30-34
8863812-2	1996	Folate and methotrexate analogues 6 and 4, with L-histidine in place of L-glutamate, were designed and synthesized as potential FPGS inhibitors.	Folic Acid	0-6	folylpolyglutamyl synthetase	Mus musculus	128-132
8863662-4	1996	This study investigated the effect of dimethylhydrazine on DNA methylation of the colonic p53 gene and the modulation of this effect by dietary folate.	Folic Acid	144-150	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	90-93
8863662-10	1996	In exon 8, significant p53 hypomethylation was observed only in the dimethylhydrazine-treated folate-depleted rats compared with controls (P = 0.038) and was effectively overcome by increasing levels of dietary folate (P = 0.008).	Folic Acid	94-100	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	23-26
8863662-10	1996	In exon 8, significant p53 hypomethylation was observed only in the dimethylhydrazine-treated folate-depleted rats compared with controls (P = 0.038) and was effectively overcome by increasing levels of dietary folate (P = 0.008).	Folic Acid	211-217	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	23-26
8622063-0	1996	Phase I trial of ZD1694, a new folate-based thymidylate synthase inhibitor, in patients with solid tumors.	Folic Acid	31-37	thymidylate synthetase	Homo sapiens	44-64
8740793-9	1996	Preliminary in vitro and clinical data have shown that the folylpolyglutamate synthetase (FPGS), the enzyme responsible for folate polyglutamylation, is another promising tool for identifying FU-FA-responsive tumors.	Folic Acid	124-130	folylpolyglutamate synthase	Homo sapiens	59-88
8740793-9	1996	Preliminary in vitro and clinical data have shown that the folylpolyglutamate synthetase (FPGS), the enzyme responsible for folate polyglutamylation, is another promising tool for identifying FU-FA-responsive tumors.	Folic Acid	124-130	folylpolyglutamate synthase	Homo sapiens	90-94
8605241-1	1996	Folylpoly-gamma-glutamate synthetase (FPGS) is essential for mammallian cell survival and is a major determinant of cytotoxicity and selectivity for folate antimetabolites.	Folic Acid	149-155	folylpolyglutamyl synthetase	Mus musculus	0-36
8605241-1	1996	Folylpoly-gamma-glutamate synthetase (FPGS) is essential for mammallian cell survival and is a major determinant of cytotoxicity and selectivity for folate antimetabolites.	Folic Acid	149-155	folylpolyglutamyl synthetase	Mus musculus	38-42
8634297-0	1996	Engineering specificity for folate into dihydrofolate reductase from Escherichia coli.	Folic Acid	28-34	Dihydrofolate reductase	Escherichia coli	40-63
8634297-6	1996	Moreover, the VLI dihydrofolate reductase is the first mutant form of E. coli DHFR to display enhanced specificity for folate [(kcat/Km)mutant/(kcat/Km)wt = 13].	Folic Acid	25-31	Dihydrofolate reductase	Escherichia coli	78-82
8958186-1	1996	Folate-based anticancer drugs with specificity for thymidylate synthase (TS) have come of age.	Folic Acid	0-6	thymidylate synthetase	Homo sapiens	51-71
8958187-8	1996	Current ornithine (Orn)-containing folate-based inhibitors of the enzyme responsible for their synthesis, folypolyglutamate synthetase (FPGS), are poorly transported, apparently because of interference by the protonated delta-amine.	Folic Acid	35-41	folylpolyglutamate synthase	Homo sapiens	106-134
8958187-8	1996	Current ornithine (Orn)-containing folate-based inhibitors of the enzyme responsible for their synthesis, folypolyglutamate synthetase (FPGS), are poorly transported, apparently because of interference by the protonated delta-amine.	Folic Acid	35-41	folylpolyglutamate synthase	Homo sapiens	136-140
8898975-0	1996	Amplification of the thymidylate synthase gene in an N10-propargyl-5,8-dideazafolic-acid-resistant human leukemia, MOLT-3 cell line developed in pteroylglutamic acid, but not in leucovorin.	Folic Acid	145-165	thymidylate synthetase	Homo sapiens	21-41
8898975-2	1996	In this study, effects of reduced and oxidized folates on the development of resistance to a thymidylate synthase (TS) inhibitor, N10-propargyl-5, 8-dideazafolic acid (CB3717), were examined in the human leukemia cell line MOLT-3.	Folic Acid	47-54	thymidylate synthetase	Homo sapiens	93-113
8898975-8	1996	These results suggest that the types of folates used during the development of CB3717 resistance may play a role in resistance, and that impaired transport of PGA, in CB3717-resistant MOLT-3 cells developed in PGA, might have accelerated amplification of the TS gene.	Folic Acid	159-162	thymidylate synthetase	Homo sapiens	259-261
8521387-1	1995	The cytotoxicity, and probably the selectivity, of folate antimetabolites depend upon the expression of the enzyme folylpoly-gamma-glutamate synthetase in tumor cells.	Folic Acid	51-57	folylpolyglutamate synthase	Homo sapiens	115-151
8533763-1	1995	Folate-dependent one-carbon metabolism is critical for the synthesis of numerous cellular constituents required for cell growth, and serine hydroxymethyltransferase (SHMT) is central to this process.	Folic Acid	0-6	serine hydroxymethyltransferase 1	Homo sapiens	166-170
8594875-5	1995	During regeneration following folic acid-induced acute renal failure, IGF-I, IGFBP-3, and IGFBP-5 mRNAs declined in abundance approximately two- to threefold.	Folic Acid	30-40	insulin like growth factor binding protein 3	Homo sapiens	77-84
8594875-8	1995	Because IGFBP-1 has been shown to stimulate cell migration and has previously been localized to the distal nephron, the site of greatest injury in the folic acid model, these data are compatible with the notion that this protein may function either directly to affect cellular repair or act as a reservoir for IGF-I under conditions of cellular damage.	Folic Acid	151-161	insulin like growth factor binding protein 1	Homo sapiens	8-15
7591238-0	1995	Growth of ovarian-carcinoma cell lines at physiological folate concentration: effect on folate-binding protein expression in vitro and in vivo.	Folic Acid	56-62	folate receptor alpha	Homo sapiens	88-110
7591238-7	1995	On SKOV3, Scatchard analysis of 125I-MOv18 binding, as well as the evaluation of total folate binding capacity, showed a 2- to 3-fold stable increase of FBP expression after long-term growth in low-folate medium.	Folic Acid	87-93	folate receptor alpha	Homo sapiens	153-156
7591238-7	1995	On SKOV3, Scatchard analysis of 125I-MOv18 binding, as well as the evaluation of total folate binding capacity, showed a 2- to 3-fold stable increase of FBP expression after long-term growth in low-folate medium.	Folic Acid	198-204	folate receptor alpha	Homo sapiens	153-156
8624289-0	1995	Folate-based thymidylate synthase inhibitors as anticancer drugs.	Folic Acid	0-6	thymidylate synthetase	Homo sapiens	13-33
7473577-1	1995	Classical antifolate inhibitors of thymidylate synthase (TS) often require the reduced folate uptake system in order to exert their antitumor effects.	Folic Acid	14-20	thymidylate synthetase	Homo sapiens	35-55
7473577-1	1995	Classical antifolate inhibitors of thymidylate synthase (TS) often require the reduced folate uptake system in order to exert their antitumor effects.	Folic Acid	14-20	thymidylate synthetase	Homo sapiens	57-59
7495480-1	1995	Quinazoline-based analogues of folic acid are a group of thymidylate synthase (TS) inhibitors that display a wide spectrum of activity for cultured tumour cells, partly due to their differential ability to form polyglutamate metabolites that are (i) more potent TS inhibitors and (ii) not readily effluxed from cells.	Folic Acid	31-41	thymidylate synthetase	Homo sapiens	57-77
7598738-0	1995	Purification of recombinant human N-acetyltransferase type 1 (NAT1) expressed in E. coli and characterization of its potential role in folate metabolism.	Folic Acid	135-141	N-acetyltransferase 1	Homo sapiens	34-60
7598738-0	1995	Purification of recombinant human N-acetyltransferase type 1 (NAT1) expressed in E. coli and characterization of its potential role in folate metabolism.	Folic Acid	135-141	N-acetyltransferase 1	Homo sapiens	62-66
7598738-6	1995	The pteroate moiety of folate, in contrast is a poor inhibitor, with 100 microM pteroate inhibiting only 40% of NAT1 activity.	Folic Acid	23-29	N-acetyltransferase 1	Homo sapiens	112-116
7598738-7	1995	A catabolite of folate para-aminobenzoly-L-glutamate has also been shown to be a NAT1 substrate with a Km value of 263 microM.	Folic Acid	16-22	N-acetyltransferase 1	Homo sapiens	81-85
7721888-1	1995	Folylpoly-gamma-glutamate synthetase (FPGS) is essential for the survival of proliferating mammalian cells and central to the action of all "classical" folate antimetabolites.	Folic Acid	152-158	folylpolyglutamate synthase	Homo sapiens	0-36
7721888-1	1995	Folylpoly-gamma-glutamate synthetase (FPGS) is essential for the survival of proliferating mammalian cells and central to the action of all "classical" folate antimetabolites.	Folic Acid	152-158	folylpolyglutamate synthase	Homo sapiens	38-42
7721888-6	1995	Transfection of the full length human cDNA into cells lacking FPGS restored their ability to grow in the absence of glycine, a product of mitochondrial folate metabolism, as well as of thymidine and purines.	Folic Acid	152-158	folylpolyglutamate synthase	Homo sapiens	62-66
7724588-1	1995	A folate analogue, 1843U89 (U89), with potential as a chemotherapeutic agent due to its potent and specific inhibition of thymidylate synthase (TS; EC 2.1.1.45), greatly enhances not only the binding of 5-fluoro-2"-deoxyuridine 5"-monophosphate (FdUMP) and dUMP to Escherichia coli TS but also that of dGMP, GMP, dIMP, and IMP.	Folic Acid	2-8	fliF	Drosophila melanogaster	302-306
7890662-7	1995	Following growth of HL-60 cells with [3H]MTX, used as a model folate compound, a large reduction in its intracellular polyglutamate pools was shown during maturation which quantitatively reflected the decline in FPGS activity as well as folate transport inward (Sirotnak, F.M., Jacobson, D.M., and Yang, C-H. (1986) J. Biol.	Folic Acid	62-68	folylpolyglutamate synthase	Homo sapiens	212-216
8527866-1	1995	Polyglutamylation of (anti)folates catalyzed by folylpolyglutamate synthetase (FPGS) determines the retention of these compounds in the cell.	Folic Acid	27-34	folylpolyglutamyl synthetase	Mus musculus	48-77
8527866-1	1995	Polyglutamylation of (anti)folates catalyzed by folylpolyglutamate synthetase (FPGS) determines the retention of these compounds in the cell.	Folic Acid	27-34	folylpolyglutamyl synthetase	Mus musculus	79-83
10993757-0	2000	Folate dependence of hyperhomocysteinemia and vascular dysfunction in cystathionine beta-synthase-deficient mice.	Folic Acid	0-6	cystathionine beta-synthase	Mus musculus	70-97
10993757-8	2000	In contrast, in mice fed a low-folate diet, maximal relaxation to acetylcholine was markedly impaired in CBS +/- mice (58 +/- 9%) compared with CBS +/+ mice (84 +/- 4%) (P = 0.01).	Folic Acid	31-37	cystathionine beta-synthase	Mus musculus	105-108
10856298-5	2000	Four mutations were in the predicted ATP-, folate-, and/or glutamate-binding sites of FPGS, and two others were clustered in a peptide predicted to be beta sheet 5, based on the crystal structure of the Lactobacillus casei enzyme.	Folic Acid	43-49	folylpolyglutamyl synthetase	Mus musculus	86-90
10896698-8	2000	Depressed patients with raised total plasma homocysteine had significant lowering of serum, red cell, and CSF folate, CSF S-adenosylmethionine and all three CSF monoamine metabolites.	Folic Acid	110-116	colony stimulating factor 2	Homo sapiens	106-109
10761765-1	2000	BACKGROUND: Raltitrexed ("Tomudex") is a folate based inhibitor of thymidylate synthase which has been registered in Europe and Australia for the treatment of advanced colorectal cancer.	Folic Acid	41-47	thymidylate synthetase	Homo sapiens	67-87
10535753-1	1999	A phenylalanine substitution for serine in the reduced folate carrier at residue 309 (RFC1-S309F) was identified in a methotrexate (MTX)-resistant cell line selected with 5-formyltetrahydrofolate (5-CHO-THF) as the sole folate source.	Folic Acid	55-61	thin fur	Mus musculus	203-206
10573207-2	1999	Raltitrexed (Tomudex), a novel folate-based inhibitor of thymidylate synthase, has demonstrated anti-tumour efficacy comparable with 5-fluorouracil and leucovorin in patients with advanced colorectal cancer (CRC).	Folic Acid	31-37	thymidylate synthetase	Homo sapiens	57-77
10449187-4	1999	Mouse NAT2 and human NAT1 have a widespread tissue distribution and the folate catabolite p-aminobenzoylglutamate (pAB-Glu) has been proposed as a candidate endogenous substrate.	Folic Acid	72-78	N-acetyltransferase 1	Homo sapiens	21-25
10485453-9	1999	Hence, overexpression of MT-II provides a growth advantage in low folate.	Folic Acid	66-72	metallothionein-2	Cricetulus griseus	25-30
10421591-0	1999	Effects of oral folic acid supplementation on endothelial function in familial hypercholesterolemia.	Folic Acid	16-26	low density lipoprotein receptor	Homo sapiens	70-99
10421591-3	1999	The present study was designed to examine whether oral folic acid supplementation could improve endothelial function as an intermediate end point for cardiovascular risk in patients with increased risk of atherosclerosis due to familial hypercholesterolemia (FH).	Folic Acid	55-65	low density lipoprotein receptor	Homo sapiens	228-257
10421591-3	1999	The present study was designed to examine whether oral folic acid supplementation could improve endothelial function as an intermediate end point for cardiovascular risk in patients with increased risk of atherosclerosis due to familial hypercholesterolemia (FH).	Folic Acid	55-65	low density lipoprotein receptor	Homo sapiens	259-261
10063803-2	1999	It mimics folate substrates and binds tightly to the active site of DHFR, perhaps in a conformation close to the transition state of the folate catalyzed reaction.	Folic Acid	10-16	Dihydrofolate reductase	Escherichia coli	68-72
10063803-2	1999	It mimics folate substrates and binds tightly to the active site of DHFR, perhaps in a conformation close to the transition state of the folate catalyzed reaction.	Folic Acid	137-143	Dihydrofolate reductase	Escherichia coli	68-72
9857014-4	1998	The thylakoidal system is able to transport dihydrofolate reductase (DHFR) when an appropriate signal is attached, and the transport efficiency is almost undiminished by the binding of folate analogs such as methotrexate that cause the protein to fold very tightly.	Folic Acid	51-57	dihydrofolate reductase	Homo sapiens	69-73
9813027-0	1998	Probing the folate-binding site of human thymidylate synthase by site-directed mutagenesis.	Folic Acid	12-18	thymidylate synthetase	Homo sapiens	41-61
9813027-8	1998	The human TS mutants (I108A and F225W), by virtue of their desirable properties, including good catalytic function and resistance to antifolate TS inhibitors, confirm the importance of amino acid residues Ile-108 and Phe-225 in the binding of folate and its analogues.	Folic Acid	137-143	thymidylate synthetase	Homo sapiens	10-12
9723869-1	1998	When maintained under continuous selection with the folate inhibitor, methotrexate, cultured Aedes albopicfus mosquito cells amplify an 200 kb region of DNA containing the dihydrofolate reductase gene.	Folic Acid	52-58	dihydrofolate reductase	Homo sapiens	172-195
9839355-2	1998	The discovery that human NAT1 acts upon p-aminobenzoylgluatamate (p-ABG) to generate p-acetamidobenzoylglutamate (p-AABG), a major urinary metabolite of folic acid, suggests that human NAT1 may play a role in folic acid metabolism and hence in the normal development of the neural tube.	Folic Acid	153-163	N-acetyltransferase 1	Homo sapiens	25-29
9839355-2	1998	The discovery that human NAT1 acts upon p-aminobenzoylgluatamate (p-ABG) to generate p-acetamidobenzoylglutamate (p-AABG), a major urinary metabolite of folic acid, suggests that human NAT1 may play a role in folic acid metabolism and hence in the normal development of the neural tube.	Folic Acid	153-163	N-acetyltransferase 1	Homo sapiens	185-189
9839355-2	1998	The discovery that human NAT1 acts upon p-aminobenzoylgluatamate (p-ABG) to generate p-acetamidobenzoylglutamate (p-AABG), a major urinary metabolite of folic acid, suggests that human NAT1 may play a role in folic acid metabolism and hence in the normal development of the neural tube.	Folic Acid	209-219	N-acetyltransferase 1	Homo sapiens	25-29
9565579-2	1998	Recently, several new and specific thymidylate synthase inhibitors that occupy the folate binding site, including Tomudex(R), BW1843U89, and Thymitaq, have demonstrated therapeutic activity in patients with advanced cancer.	Folic Acid	83-89	thymidylate synthetase	Homo sapiens	35-55
9572847-1	1998	Analysis of the dihydrofolate reductase (DHFR) complex with folate by two-dimensional heteronuclear (1H-15N) nuclear magnetic relaxation revealed that isolated residues exhibit diverse backbone fluctuations on the nanosecond to picosecond time scale [Epstein, D. M., Benkovic, S. J., and Wright, P. E. (1995) Biochemistry 34, 11037-11048].	Folic Acid	23-29	Dihydrofolate reductase	Escherichia coli	41-45
9545095-5	1998	The folate receptor alpha (FR-alpha) gene codes for the protein responsible for binding folate, which is the first, and only, folate-dependent step in folate transport.	Folic Acid	4-10	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	27-35
9545095-5	1998	The folate receptor alpha (FR-alpha) gene codes for the protein responsible for binding folate, which is the first, and only, folate-dependent step in folate transport.	Folic Acid	88-94	folate receptor alpha	Homo sapiens	4-25
9545095-5	1998	The folate receptor alpha (FR-alpha) gene codes for the protein responsible for binding folate, which is the first, and only, folate-dependent step in folate transport.	Folic Acid	88-94	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	27-35
9545095-5	1998	The folate receptor alpha (FR-alpha) gene codes for the protein responsible for binding folate, which is the first, and only, folate-dependent step in folate transport.	Folic Acid	88-94	folate receptor alpha	Homo sapiens	4-25
9545095-5	1998	The folate receptor alpha (FR-alpha) gene codes for the protein responsible for binding folate, which is the first, and only, folate-dependent step in folate transport.	Folic Acid	88-94	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	27-35
9508241-1	1998	Recent studies have identified a (CCG)n repeat in the 5" untranslated region of the CBL2 protooncogene (11q23.3) and have demonstrated that expansion of this repeat causes expression of the folate-sensitive fragile site FRA11B.	Folic Acid	190-196	Cbl proto-oncogene	Homo sapiens	84-88
9508241-1	1998	Recent studies have identified a (CCG)n repeat in the 5" untranslated region of the CBL2 protooncogene (11q23.3) and have demonstrated that expansion of this repeat causes expression of the folate-sensitive fragile site FRA11B.	Folic Acid	190-196	Cbl proto-oncogene	Homo sapiens	220-226
9530547-2	1998	Raltitrexed (ZD-1694) is a quinazoline-based folate analogue that exerts its cytotoxic activity by the specific inhibition of thymidylate synthase.	Folic Acid	45-51	thymidylate synthetase	Homo sapiens	126-146
9166787-5	1997	Substitution of the amino-terminal portion (residues 1-92) in the mature FR-alpha polypeptide with the corresponding segment of FR-beta resulted in folate binding characteristics similar to FR-beta.	Folic Acid	148-154	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	73-81
9166787-5	1997	Substitution of the amino-terminal portion (residues 1-92) in the mature FR-alpha polypeptide with the corresponding segment of FR-beta resulted in folate binding characteristics similar to FR-beta.	Folic Acid	148-154	folate receptor beta	Homo sapiens	128-135
9166787-7	1997	In this fashion, it was determined that the alanine residue at position 49 in FR-alpha was critical for its functional divergence from FR-beta, since substitution at this position with Leu (the corresponding residue in FR-beta) resulted in the folate binding characteristics of FR-beta.	Folic Acid	244-250	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	78-86
9166787-7	1997	In this fashion, it was determined that the alanine residue at position 49 in FR-alpha was critical for its functional divergence from FR-beta, since substitution at this position with Leu (the corresponding residue in FR-beta) resulted in the folate binding characteristics of FR-beta.	Folic Acid	244-250	folate receptor beta	Homo sapiens	219-226
9166787-7	1997	In this fashion, it was determined that the alanine residue at position 49 in FR-alpha was critical for its functional divergence from FR-beta, since substitution at this position with Leu (the corresponding residue in FR-beta) resulted in the folate binding characteristics of FR-beta.	Folic Acid	244-250	folate receptor beta	Homo sapiens	219-226
9166787-8	1997	Reciprocal substitution in FR-beta with peptide 1-92 of FR-alpha resulted in poor expression of a [3H]folic acid binding protein.	Folic Acid	102-112	folate receptor beta	Homo sapiens	27-34
9166787-8	1997	Reciprocal substitution in FR-beta with peptide 1-92 of FR-alpha resulted in poor expression of a [3H]folic acid binding protein.	Folic Acid	102-112	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	56-64
9166787-9	1997	By analysis of chimeric constructs, the poor [3H]folic acid binding of the FR-alpha(1-92)/beta(93-237) chimera could be attributed to interference of a short segment from FR-alpha in the vicinity of Ala 49 (peptide 39-59) with proper folding of the chimera.	Folic Acid	49-59	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	75-83
9177839-4	1997	In this paper, it is shown that the size of these conjugates can be reduced to the smallest bispecific agent yet described (30 kDa) by attaching folate to a single-chain antibody, scFv, of the anti-TCR antibody KJ16.	Folic Acid	145-151	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	198-201
9097976-0	1997	Alterations in hepatic p53 gene methylation patterns during tumor progression with folate/methyl deficiency in the rat.	Folic Acid	83-89	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	23-26
9291820-3	1997	On these 14 cell lines grown without l-FA supplementation, a significant positive correlation was demonstrated between basal intracellular folate concentration and FPGS activity.	Folic Acid	139-145	folylpolyglutamate synthase	Homo sapiens	164-168
8988912-4	1997	Our data indicate that folate deficiency induces DNA strand breaks and hypomethylation within the p53 gene.	Folic Acid	23-29	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	98-101
9533019-0	1997	Mapping FRA11A, a folate-sensitive fragile site in human chromosome band 11q13.3.	Folic Acid	18-24	fragile site, folic acid type, rare, fra(11)(q13.3)	Homo sapiens	8-14
9533019-1	1997	FRA11A, a rare folate-sensitive fragile site assigned to 11q13.3, lies in an area of genomic instability associated with several diseases and amplification events.	Folic Acid	15-21	fragile site, folic acid type, rare, fra(11)(q13.3)	Homo sapiens	0-6
9040540-0	1997	Male rats fed methyl- and folate-deficient diets with or without niacin develop hepatic carcinomas associated with decreased tissue NAD concentrations and altered poly(ADP-ribose) polymerase activity.	Folic Acid	26-32	poly (ADP-ribose) polymerase 1	Rattus norvegicus	163-190
9040540-1	1997	Folate is an essential cofactor in the generation of endogenous methionine, and there is evidence that folate deficiency exacerbates the effects of a diet low in choline and methionine, including alterations in poly(ADP-ribose) polymerase (PARP) activity, an enzyme associated with DNA replication and repair.	Folic Acid	0-6	poly (ADP-ribose) polymerase 1	Rattus norvegicus	240-244
9040540-1	1997	Folate is an essential cofactor in the generation of endogenous methionine, and there is evidence that folate deficiency exacerbates the effects of a diet low in choline and methionine, including alterations in poly(ADP-ribose) polymerase (PARP) activity, an enzyme associated with DNA replication and repair.	Folic Acid	103-109	poly (ADP-ribose) polymerase 1	Rattus norvegicus	211-238
9040540-1	1997	Folate is an essential cofactor in the generation of endogenous methionine, and there is evidence that folate deficiency exacerbates the effects of a diet low in choline and methionine, including alterations in poly(ADP-ribose) polymerase (PARP) activity, an enzyme associated with DNA replication and repair.	Folic Acid	103-109	poly (ADP-ribose) polymerase 1	Rattus norvegicus	240-244
9040540-2	1997	Because PARP requires NAD as its substrate, we postulated that a deficiency of both folate and niacin would enhance the development of liver cancer in rats fed a diet deficient in methionine and choline.	Folic Acid	84-90	poly (ADP-ribose) polymerase 1	Rattus norvegicus	8-12
8973205-7	1996	Treatment of L1210A cell membranes with mild base rendered the protein PI-PLC sensitive as expected for GPI anchors acylated in the inositol ring and also decreased the affinities of the membrane associated FR for reduced folates.	Folic Acid	222-229	protein disulfide isomerase associated 3	Mus musculus	71-77
8912628-6	1996	Although the complete in vivo function of gamma-glutamyl hydrolase in plants is unclear, it is known that the protein plays a critical role in folate metabolism and therefore likely in meeting the physiological demands of growing plant tissues.	Folic Acid	143-149	gamma-glutamyl hydrolase	Glycine max	42-66
8651274-1	1996	The folate-sensitive fragile site FRAXE is located in proximal Xq28 of the human X chromosome and lies approximately 600 kb distal to the fragile X syndrome (FRAXA) fragile site at Xq27.3.	Folic Acid	4-10	fragile site, folic acid type, rare, fra(X)(q28) E	Homo sapiens	34-39
8815749-4	1996	In the presence of folate, there is a competition between folate and the G6PDH-folate conjugate for the binding site of the folate binding protein, and the activity of the conjugate is recovered.	Folic Acid	19-25	folate receptor alpha	Homo sapiens	124-146
8815749-4	1996	In the presence of folate, there is a competition between folate and the G6PDH-folate conjugate for the binding site of the folate binding protein, and the activity of the conjugate is recovered.	Folic Acid	58-64	folate receptor alpha	Homo sapiens	124-146
8815749-4	1996	In the presence of folate, there is a competition between folate and the G6PDH-folate conjugate for the binding site of the folate binding protein, and the activity of the conjugate is recovered.	Folic Acid	58-64	folate receptor alpha	Homo sapiens	124-146
8673085-1	1996	Five folate-sensitive fragile sites have been characterized at the molecular level (FRAXA, FRAXE, FRAXF, FRA16A and FRA11B).	Folic Acid	5-11	fragile site, folic acid type, rare, fra(X)(q28) E	Homo sapiens	91-96
8673085-1	1996	Five folate-sensitive fragile sites have been characterized at the molecular level (FRAXA, FRAXE, FRAXF, FRA16A and FRA11B).	Folic Acid	5-11	fragile site, folic acid type, rare, fra(16)(p13.11)	Homo sapiens	105-111
8673085-1	1996	Five folate-sensitive fragile sites have been characterized at the molecular level (FRAXA, FRAXE, FRAXF, FRA16A and FRA11B).	Folic Acid	5-11	Cbl proto-oncogene	Homo sapiens	116-122
8673085-4	1996	FRAXE is a rare folate sensitive fragile site only recently recognized.	Folic Acid	16-22	fragile site, folic acid type, rare, fra(X)(q28) E	Homo sapiens	0-5
8595169-6	1996	Only SKOV3 and SW626 cells grown in folic acid-depleted medium showed increased FBP expression, about 3- and 8-fold respectively.	Folic Acid	36-46	folate receptor alpha	Homo sapiens	80-83
9816165-1	1996	Folate analogues that inhibit thymidylate synthase (TS) selectively were developed based on TS and folate molecular structures and properties.	Folic Acid	0-6	thymidylate synthetase	Homo sapiens	30-50
9816165-1	1996	Folate analogues that inhibit thymidylate synthase (TS) selectively were developed based on TS and folate molecular structures and properties.	Folic Acid	99-105	thymidylate synthetase	Homo sapiens	30-50
8547345-3	1996	The apo-form of the folate binding protein thus obtained was purified by affinity chromatography using pteroylglutamic acid covalently coupled to Sepharose 4B.	Folic Acid	103-123	glycine N-methyltransferase	Rattus norvegicus	20-42
8869756-15	1996	These studies support the use of folic acid supplementation for cancer patients treated with antifolate therapy in order to prevent the biochemical changes in FR and FPGS associated with folate deficiency, prevent delayed toxicity to GARFT inhibitors and enhance the therapeutic potential of this class of drugs.	Folic Acid	33-43	folylpolyglutamate synthase	Homo sapiens	166-170
8567390-1	1995	One of the resistance mechanisms to folate-based thymidylate synthase (TS) inhibitors is the increase in TS activity in tumor cells.	Folic Acid	36-42	thymidylate synthetase	Homo sapiens	49-69
8567390-1	1995	One of the resistance mechanisms to folate-based thymidylate synthase (TS) inhibitors is the increase in TS activity in tumor cells.	Folic Acid	36-42	thymidylate synthetase	Homo sapiens	71-73
8567390-1	1995	One of the resistance mechanisms to folate-based thymidylate synthase (TS) inhibitors is the increase in TS activity in tumor cells.	Folic Acid	36-42	thymidylate synthetase	Homo sapiens	105-107
7568072-3	1995	In this report, conjugates that consist of folate covalently linked to anti-TCR antibodies are shown to be potent in mediating lysis of tumor cells that express either the alpha or beta isoform of the FR.	Folic Acid	43-49	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	76-79
8527095-3	1995	DESIGN AND METHODS: We constructed a chimeric protein between Tat and dihydrofolate reductase (DHFR), a cytosolic enzyme that binds tightly to the folate analogue methotrexate (MTX).	Folic Acid	77-83	dihydrofolate reductase	Homo sapiens	95-99
7881408-2	1994	However, one case report has highlighted a possible relationship between the inheritance of a rare folate-sensitive fragile site in band 11q23.3 (FRA11B) and the chromosome 11q23--&gt;qter deletion in Jacobsen (11q-) syndrome.	Folic Acid	99-105	Cbl proto-oncogene	Homo sapiens	146-152
8064803-3	1994	Structure-affinity relationship (SAR) studies for the 5-HT1A receptor site are presented for two series of heterobicyclic phenylpiperazines with N4-aralkyl substituents: 4-aralkyl derivatives of 1-(2,3-dihydro-1,4-benzodioxin-5-yl)piperazine (3) and 1-(benzo[b]furan-7-yl)piperazine (4).	Folic Acid	145-147	5-hydroxytryptamine receptor 1A	Homo sapiens	54-69
7517720-1	1994	Folylpolyglutamate synthetase (FPGS) is responsible for the metabolism of natural folates and a broad range of folate antagonists to polyglutamate derivatives.	Folic Acid	82-89	folylpolyglutamate synthase	Homo sapiens	0-29
7517720-1	1994	Folylpolyglutamate synthetase (FPGS) is responsible for the metabolism of natural folates and a broad range of folate antagonists to polyglutamate derivatives.	Folic Acid	82-89	folylpolyglutamate synthase	Homo sapiens	31-35
7517720-1	1994	Folylpolyglutamate synthetase (FPGS) is responsible for the metabolism of natural folates and a broad range of folate antagonists to polyglutamate derivatives.	Folic Acid	82-88	folylpolyglutamate synthase	Homo sapiens	0-29
7517720-1	1994	Folylpolyglutamate synthetase (FPGS) is responsible for the metabolism of natural folates and a broad range of folate antagonists to polyglutamate derivatives.	Folic Acid	82-88	folylpolyglutamate synthase	Homo sapiens	31-35
8126512-2	1994	A severe folate deficiency state was found in CSF in combination with a normal serum and red cell folate state.	Folic Acid	9-15	colony stimulating factor 2	Homo sapiens	46-49
8114682-1	1994	Previous attempts to design inhibitors of mammalian folylpolyglutamate synthetase (FPGS) have resulted in three classes of active compounds, all of which have charged moieties in the side chain, but structural alteration of the rest of the folate molecule has not seemed to be an avenue for drug discovery.	Folic Acid	240-246	folylpolyglutamate synthase	Homo sapiens	52-81
8114682-1	1994	Previous attempts to design inhibitors of mammalian folylpolyglutamate synthetase (FPGS) have resulted in three classes of active compounds, all of which have charged moieties in the side chain, but structural alteration of the rest of the folate molecule has not seemed to be an avenue for drug discovery.	Folic Acid	240-246	folylpolyglutamate synthase	Homo sapiens	83-87
8114682-3	1994	We now report that substituents at the 7-, 2"-, or 3"-position of 2-desamino-2-methyl-4-hydroxyquinazoline antifolates decrease or prevent the catalysis of diglutamate formation by FPGS but are compatible with efficient binding to the reduced folate carrier system.	Folic Acid	111-117	folylpolyglutamate synthase	Homo sapiens	181-185
8114682-10	1994	We conclude that the region of the folate molecule bounded by the 7-, 6-, 9-, 10-, 3"-, and 2"-positions, the "bay region," is of major importance both for the binding of folates and folate analogs to FPGS and for the assumption of a conformation of the enzyme-substrate complex compatible with catalysis.	Folic Acid	35-41	folylpolyglutamate synthase	Homo sapiens	201-205
8114682-10	1994	We conclude that the region of the folate molecule bounded by the 7-, 6-, 9-, 10-, 3"-, and 2"-positions, the "bay region," is of major importance both for the binding of folates and folate analogs to FPGS and for the assumption of a conformation of the enzyme-substrate complex compatible with catalysis.	Folic Acid	171-178	folylpolyglutamate synthase	Homo sapiens	201-205
8114682-10	1994	We conclude that the region of the folate molecule bounded by the 7-, 6-, 9-, 10-, 3"-, and 2"-positions, the "bay region," is of major importance both for the binding of folates and folate analogs to FPGS and for the assumption of a conformation of the enzyme-substrate complex compatible with catalysis.	Folic Acid	171-177	folylpolyglutamate synthase	Homo sapiens	201-205
10889164-3	2000	This study investigated the effects of dietary folate on DNA strand breaks in the p53 and Apc genes, and how these changes are related to steady-state levels of the corresponding transcripts.	Folic Acid	47-53	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	82-85
8177846-2	1994	Twenty patients fulfilled the following criteria (a) they presented with neurological findings for which no other cause could be found (b) the serum or red cell and/or the CSF folate was low (c) the serum vitamin B12 or vitamin B12 absorption was normal and (d) they showed a significant response to folic acid.	Folic Acid	176-182	colony stimulating factor 2	Homo sapiens	172-175
10889164-10	2000	Folate supplementation at 4 times the basal requirement significantly increased p53 integrity compared with the basal and deficient diets (P&lt;0.05).	Folic Acid	0-6	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	80-83
10889164-11	2000	p53 integrity in exons 5-8 was significantly correlated with folate status (P&lt;0.03).	Folic Acid	61-67	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	0-3
10889164-12	2000	Dietary folate deprivation progressively decreased, whereas supplementation increased, steady-state levels of p53 transcript over 5 weeks (P&lt;0.05).	Folic Acid	8-14	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	110-113
8294436-0	1994	Mode of binding of folate analogs to thymidylate synthase.	Folic Acid	19-25	thymidylate synthetase	Homo sapiens	37-57
8294436-4	1994	Thymidylate synthase bound both mono and polyglutamylated folate substrates and analogs more tightly in the presence of deoxyuridylate.	Folic Acid	58-64	thymidylate synthetase	Homo sapiens	0-20
10889164-14	2000	Steady-state levels of p53 transcript were significantly correlated with folate status and p53 integrity in exons 5-8 (P&lt;0.002).	Folic Acid	73-79	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	23-26
10783371-5	2000	Supplementation of folic acid led to an increase of single CD56(pos) cells, but cytotoxic function appeared unaffected.	Folic Acid	19-29	neural cell adhesion molecule 1	Homo sapiens	59-63
7942284-7	1994	Although DHFR is an extremely well-studied enzyme, there is still some uncertainty about its kinetics, mechanism for reduction of folate, multiple forms, and activation by a diverse group of agents.	Folic Acid	130-136	dihydrofolate reductase	Homo sapiens	9-13
10751329-0	2000	Folate deficiency reduces the GPI-anchored folate-binding protein in rat renal tubules.	Folic Acid	0-6	glycine N-methyltransferase	Rattus norvegicus	43-65
7987985-0	1994	Biochemical effects of folate-based inhibitors of thymidylate synthase in MGH-U1 cells.	Folic Acid	23-29	thymidylate synthetase	Homo sapiens	50-70
8174202-0	1994	Comparative cytotoxicity of folate-based inhibitors of thymidylate synthase and 5-fluorouracil +/- leucovorin in MGH-U1 cells.	Folic Acid	28-34	thymidylate synthetase	Homo sapiens	55-75
10751329-7	2000	Because the GPI-FBP is on the brush borders of the proximal renal tubules and provides for the reabsorption of folate, this function diminishes when the protein decreases in folate deficiency.	Folic Acid	111-117	glycine N-methyltransferase	Rattus norvegicus	16-19
10751329-7	2000	Because the GPI-FBP is on the brush borders of the proximal renal tubules and provides for the reabsorption of folate, this function diminishes when the protein decreases in folate deficiency.	Folic Acid	174-180	glycine N-methyltransferase	Rattus norvegicus	16-19
10847455-2	2000	TS has been used as a target for cancer chemotherapy in the development of fluoropyrimidines such as 5-fluorouracil (5-FU) and 5-fluorodeoxyuridine and of novel folate-based TS inhibitors such as ZD1694 (Tomudex, Raltitrexed), ZD9331, LY231514 (ALIMTA, Pemetrexed), AG337 (Thymitaq, Nolatrexed) and AG331.	Folic Acid	161-167	thymidylate synthetase	Homo sapiens	0-2
8194901-1	1994	Human folate receptor (hFR, folate-binding protein) is a single-chain glycoprotein with high specific affinity for folic acid and methotrexate.	Folic Acid	115-125	folate receptor alpha	Homo sapiens	28-50
10847455-2	2000	TS has been used as a target for cancer chemotherapy in the development of fluoropyrimidines such as 5-fluorouracil (5-FU) and 5-fluorodeoxyuridine and of novel folate-based TS inhibitors such as ZD1694 (Tomudex, Raltitrexed), ZD9331, LY231514 (ALIMTA, Pemetrexed), AG337 (Thymitaq, Nolatrexed) and AG331.	Folic Acid	161-167	thymidylate synthetase	Homo sapiens	174-176
10648167-1	2000	Folylpoly-gamma-glutamate synthetase activity is central to the operation of folate metabolism and is essential for the survival of mammalian stem cell populations but the very low levels of endogenous expression of this enzyme have greatly limited its study.	Folic Acid	77-83	folylpolyglutamate synthase	Homo sapiens	0-36
8408018-2	1993	Folate metabolism in Chinese hamster ovary cells expressing Escherichia coli or human folylpoly-gamma-glutamate synthetase activity.	Folic Acid	0-6	folylpolyglutamate synthase	Homo sapiens	86-122
8408018-5	1993	Only low levels of FPGS are required to enable cellular metabolism of folates to forms that are retained by mammalian cells.	Folic Acid	70-77	folylpolyglutamate synthase	Homo sapiens	19-23
8408018-7	1993	At low medium folate concentrations, folate accumulation by transfectants expressing human FPGS was not responsive to FPGS levels as the limiting step in metabolism was beyond the triglutamate, the chain length required for retention.	Folic Acid	37-43	folylpolyglutamate synthase	Homo sapiens	91-95
8399157-0	1993	Fluorine-19 nuclear magnetic resonance studies of binary and ternary complexes of thymidylate synthase utilizing a fluorine-labeled folate analogue.	Folic Acid	132-138	thymidylate synthetase	Homo sapiens	82-102
8399157-1	1993	Traditional fluorine-19 nuclear magnetic resonance (19F NMR) studies of thymidylate synthase (TS) have utilized the fluorine substituent of 5-fluorodeoxyuridine 5"-monophosphate (FdUMP), a mechanism-based inhibitor of the enzyme, in complexes with various folate and folate analogues in order to establish a paradigm for the formation of binary and ternary complexes.	Folic Acid	256-262	thymidylate synthetase	Homo sapiens	72-92
8399157-1	1993	Traditional fluorine-19 nuclear magnetic resonance (19F NMR) studies of thymidylate synthase (TS) have utilized the fluorine substituent of 5-fluorodeoxyuridine 5"-monophosphate (FdUMP), a mechanism-based inhibitor of the enzyme, in complexes with various folate and folate analogues in order to establish a paradigm for the formation of binary and ternary complexes.	Folic Acid	267-273	thymidylate synthetase	Homo sapiens	72-92
8261698-9	1993	In relation to the increase in taurine, metabolic slowing-down of the folate cycle which has been reported in ALS was suggested from reduced activity of N5,N10-methylenetetrahydrofolate reductase (MTR), one of the three enzymes of this metabolic cycle.	Folic Acid	70-76	DNA binding protein N5	Rattus norvegicus	153-159
8261698-9	1993	In relation to the increase in taurine, metabolic slowing-down of the folate cycle which has been reported in ALS was suggested from reduced activity of N5,N10-methylenetetrahydrofolate reductase (MTR), one of the three enzymes of this metabolic cycle.	Folic Acid	70-76	methylenetetrahydrofolate reductase	Rattus norvegicus	160-195
10601577-1	2000	The folate-sensitive fragile site FRAXE is located in proximal Xq28 of the human X chromosome and lies approximately 600 kb distal to the fragile X syndrome (FRAXA) fragile site at Xq27.3.	Folic Acid	4-10	fragile site, folic acid type, rare, fra(X)(q28) E	Homo sapiens	34-39
10608809-3	1999	We now report that the inhibition of glycine N-methyltransferase by (6S)-5-CH(3)-H(4)PteGlu(5) is noncompetitive with regard to both S-adenosylmethionine and glycine.	Folic Acid	85-91	glycine N-methyltransferase	Rattus norvegicus	37-64
8325888-1	1993	We have investigated the mechanism of inactivation of thymidylate synthase (TS) by ICI D1694 (a folate-based quinazoline) in normal versus tumor-derived human mammary epithelial cells.	Folic Acid	96-102	thymidylate synthetase	Homo sapiens	54-74
8325888-1	1993	We have investigated the mechanism of inactivation of thymidylate synthase (TS) by ICI D1694 (a folate-based quinazoline) in normal versus tumor-derived human mammary epithelial cells.	Folic Acid	96-102	thymidylate synthetase	Homo sapiens	76-78
8325888-7	1993	5,10-Methylenetetrahydrofolate (via folinic acid), however, did block the effects of ICI D1694, showing that the drug has its effect upon both detainment and enzyme inhibition by binding to the folate substrate site of TS.	Folic Acid	24-30	thymidylate synthetase	Homo sapiens	219-221
10626793-1	1999	Folates and folate antimetabolites are metabolically trapped in mammalian cells as polyglutamates, a process catalyzed by folylpoly-gamma-glutamate synthetase (FPGS).	Folic Acid	0-7	folylpolyglutamate synthase	Homo sapiens	122-158
8387781-6	1993	Although these cells contain a membrane folate-binding protein (FBP) involved in the uptake of free folate, no studies have been conducted to evaluate whether the folate-protein conjugates enter cells via the same protein.	Folic Acid	40-46	folate receptor alpha	Homo sapiens	64-67
8387781-7	1993	To address this issue, HeLa cell monolayers were treated with folate-labelled 125I-RNAase under various conditions characteristic of FBP-mediated folate uptake.	Folic Acid	62-68	folate receptor alpha	Homo sapiens	133-136
8387781-7	1993	To address this issue, HeLa cell monolayers were treated with folate-labelled 125I-RNAase under various conditions characteristic of FBP-mediated folate uptake.	Folic Acid	146-152	folate receptor alpha	Homo sapiens	133-136
10626793-1	1999	Folates and folate antimetabolites are metabolically trapped in mammalian cells as polyglutamates, a process catalyzed by folylpoly-gamma-glutamate synthetase (FPGS).	Folic Acid	0-7	folylpolyglutamate synthase	Homo sapiens	160-164
10626793-1	1999	Folates and folate antimetabolites are metabolically trapped in mammalian cells as polyglutamates, a process catalyzed by folylpoly-gamma-glutamate synthetase (FPGS).	Folic Acid	12-18	folylpolyglutamate synthase	Homo sapiens	122-158
10626793-1	1999	Folates and folate antimetabolites are metabolically trapped in mammalian cells as polyglutamates, a process catalyzed by folylpoly-gamma-glutamate synthetase (FPGS).	Folic Acid	12-18	folylpolyglutamate synthase	Homo sapiens	160-164
10535753-9	1999	This study represents another example of a single mutation in RFC1 that markedly impairs MTX influx but partially preserves transport of reduced folates when cells are selected with 5-CHO-THF as the available folate substrate.	Folic Acid	145-152	thin fur	Mus musculus	188-191
8471033-13	1993	The increased GNMT activity is therefore consistent with decreased folate levels and decreased inhibition of enzyme activity.	Folic Acid	67-73	glycine N-methyltransferase	Rattus norvegicus	14-18
10535753-9	1999	This study represents another example of a single mutation in RFC1 that markedly impairs MTX influx but partially preserves transport of reduced folates when cells are selected with 5-CHO-THF as the available folate substrate.	Folic Acid	145-151	thin fur	Mus musculus	188-191
10554030-0	1999	Determinants of activity of the antifolate thymidylate synthase inhibitors Tomudex (ZD1694) and GW1843U89 against mono- and multilayered colon cancer cell lines under folate-restricted conditions.	Folic Acid	36-42	thymidylate synthetase	Homo sapiens	43-63
10554030-6	1999	At nonsaturating substrate concentrations, the catalytic activity of TS was similar in mono- and multilayers grown under high folate conditions but lower in multilayers at saturating concentrations.	Folic Acid	126-132	thymidylate synthetase	Homo sapiens	69-71
10554030-7	1999	In cells grown under low folate conditions, TS catalytic activity was 3-6-fold lower in multilayers than in monolayers.	Folic Acid	25-31	thymidylate synthetase	Homo sapiens	44-46
10554030-21	1999	These effects of folate homeostasis may explain some of the variable results seen in treatment of solid tumors with new antifolate TS inhibitors.	Folic Acid	17-23	thymidylate synthetase	Homo sapiens	131-133
10584062-1	1999	We have investigated the importance of polarization by the enzyme dihydrofolate reductase (DHFR) on its substrates, folate and dihydrofolate, using a series of quantum mechanical (QM) techniques (Hartree-Fock (HF), Moller-Plesset second-order perturbation theory (MP2), local density approximation (LDA) and generalized gradient approximation (GGA) density functional theory (DFT) calculations) in which the bulk enzyme is included in the calculations as point charges.	Folic Acid	73-79	dihydrofolate reductase	Homo sapiens	91-95
7851205-7	1995	We observed that supplemental folic acid suppressed carcinogen-induced ornithine decarboxylase activity by 64% in the old and 74% in the young rats.	Folic Acid	30-40	ornithine decarboxylase 1	Rattus norvegicus	71-94
8053928-5	1994	Addition of the reduced folate leucovorin potentiated the effects induced by FdUrd, indicating that thymidylate synthase inhibition is an important initial step in drug effect followed by DNA fragmentation and suppression of c-myc expression.	Folic Acid	24-30	thymidylate synthetase	Homo sapiens	100-120
8053928-5	1994	Addition of the reduced folate leucovorin potentiated the effects induced by FdUrd, indicating that thymidylate synthase inhibition is an important initial step in drug effect followed by DNA fragmentation and suppression of c-myc expression.	Folic Acid	24-30	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	225-230
8072237-6	1994	The recovery test of the two serum vitamins with the use of cyanocobalamin and pteroylglutamic acid (J.P.) were finely showed the rations of 95.2-99.0% for vit.	Folic Acid	79-99	vitrin	Bos taurus	35-38
7513252-10	1994	KB cells and JEG-3 cells grown at low folate concentrations further up-regulated FR-alpha but not FR-beta.	Folic Acid	38-44	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	81-89
7513252-11	1994	CONCLUSIONS: Although FR-beta is the more common isoform, FR-alpha and FR-beta are differentially regulated in normal tissues, carcinomas, nonepithelial malignancies, and immortalized cells or in response to changes in extracellular folate concentrations.	Folic Acid	233-239	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	58-66
7513252-11	1994	CONCLUSIONS: Although FR-beta is the more common isoform, FR-alpha and FR-beta are differentially regulated in normal tissues, carcinomas, nonepithelial malignancies, and immortalized cells or in response to changes in extracellular folate concentrations.	Folic Acid	233-239	folate receptor beta	Homo sapiens	71-78
8195828-4	1993	Many folate analogues are competitive inhibitors of DHFR, and while some classes show no selectivity, suitably substituted diaminopyrimidines are several thousands times more active against bacterial than mammalian DHFR and are thus effective and safe antibiotics.	Folic Acid	5-11	dihydrofolate reductase	Homo sapiens	52-56
8195828-4	1993	Many folate analogues are competitive inhibitors of DHFR, and while some classes show no selectivity, suitably substituted diaminopyrimidines are several thousands times more active against bacterial than mammalian DHFR and are thus effective and safe antibiotics.	Folic Acid	5-11	dihydrofolate reductase	Homo sapiens	215-219
8408018-8	1993	The rate-limiting step in folate metabolism in cells expressing the E. coli enzyme was the conversion of diglutamate to triglutamate, and, at low FPGS levels, the E. coli enzyme was about 50-fold less effective than the human FPGS in enabling cellular folate accumulation.	Folic Acid	26-32	folylpolyglutamate synthase	Homo sapiens	146-150
8408018-8	1993	The rate-limiting step in folate metabolism in cells expressing the E. coli enzyme was the conversion of diglutamate to triglutamate, and, at low FPGS levels, the E. coli enzyme was about 50-fold less effective than the human FPGS in enabling cellular folate accumulation.	Folic Acid	26-32	folylpolyglutamate synthase	Homo sapiens	226-230
8408018-8	1993	The rate-limiting step in folate metabolism in cells expressing the E. coli enzyme was the conversion of diglutamate to triglutamate, and, at low FPGS levels, the E. coli enzyme was about 50-fold less effective than the human FPGS in enabling cellular folate accumulation.	Folic Acid	252-258	folylpolyglutamate synthase	Homo sapiens	226-230
8408018-9	1993	These data suggest that cellular accumulation of any folate analog whose mono- or diglutamate derivative is a poor substrate for FPGS would be very responsive to the level of FPGS activity.	Folic Acid	53-59	folylpolyglutamate synthase	Homo sapiens	129-133
8408018-9	1993	These data suggest that cellular accumulation of any folate analog whose mono- or diglutamate derivative is a poor substrate for FPGS would be very responsive to the level of FPGS activity.	Folic Acid	53-59	folylpolyglutamate synthase	Homo sapiens	175-179
8408019-2	1993	Effect of folylpoly-gamma-glutamate synthetase substrate specificity and level on folate metabolism and folylpoly-gamma-glutamate specificity of metabolic cycles of one-carbon metabolism.	Folic Acid	82-88	folylpolyglutamate synthase	Homo sapiens	10-46
8408019-5	1993	Essentially all transported folate was metabolized to retained polyglutamate derivatives, the chain length of which varied with the level of FPGS activity.	Folic Acid	28-34	folylpolyglutamate synthase	Homo sapiens	141-145
8408019-6	1993	As medium folate concentration increased through the physiological to the pharmacological range, cellular folate accumulation became proportional to FPGS activity and the chain length of intracellular folates decreased.	Folic Acid	10-16	folylpolyglutamate synthase	Homo sapiens	149-153
8408019-6	1993	As medium folate concentration increased through the physiological to the pharmacological range, cellular folate accumulation became proportional to FPGS activity and the chain length of intracellular folates decreased.	Folic Acid	106-112	folylpolyglutamate synthase	Homo sapiens	149-153
8408019-7	1993	At high folate concentrations, competition between substrates for FPGS limited the extent of polyglutamylation and less than 5% of transported folate was retained by the cell.	Folic Acid	8-14	folylpolyglutamate synthase	Homo sapiens	66-70
8447363-1	1993	Folate-binding protein (FBP) is involved in folate reabsorption in the renal proximal tubule.	Folic Acid	44-50	glycine N-methyltransferase	Rattus norvegicus	0-22
8447363-1	1993	Folate-binding protein (FBP) is involved in folate reabsorption in the renal proximal tubule.	Folic Acid	44-50	glycine N-methyltransferase	Rattus norvegicus	24-27
8447363-6	1993	The results are consistent with reabsorption of folate through endocytosis of the FBP-folate complex followed by dissociation and recycling of FBP.	Folic Acid	48-54	glycine N-methyltransferase	Rattus norvegicus	82-85
8447363-6	1993	The results are consistent with reabsorption of folate through endocytosis of the FBP-folate complex followed by dissociation and recycling of FBP.	Folic Acid	48-54	glycine N-methyltransferase	Rattus norvegicus	143-146
8447363-6	1993	The results are consistent with reabsorption of folate through endocytosis of the FBP-folate complex followed by dissociation and recycling of FBP.	Folic Acid	86-92	glycine N-methyltransferase	Rattus norvegicus	82-85
8329665-1	1993	High-affinity 3H-folate binding in Triton X-100 solubilized human mammary gland tissue displayed characteristics, e.g. apparent positive cooperativity and increasing affinity with decreasing concentration of folate binding protein, shown to be typical of specific folate binding.	Folic Acid	17-23	folate receptor alpha	Homo sapiens	208-230
1506416-5	1992	As with cystic kidneys, the folic acid-injured kidneys showed increased c-fos responsiveness to FBS in cell culture.	Folic Acid	28-38	FBJ osteosarcoma oncogene	Mus musculus	72-77
1637816-1	1992	The kinetics of the NADPH-dependent reduction of 7,8-dihydrofolate, folate, and 7,8-dihydrobiopterin by human dihydrofolate reductase have been examined over the pH range from 4.0 to 9.5.	Folic Acid	60-66	dihydrofolate reductase	Homo sapiens	110-133
1418238-0	1992	Non-essential activation of rat liver porphobilinogen-deaminase by folic acid.	Folic Acid	67-77	hydroxymethylbilane synthase	Rattus norvegicus	38-63
1418238-1	1992	This report demonstrates the ability of folic acid to activate rat liver porphobilinogen-deaminase (PBG-D).	Folic Acid	40-50	hydroxymethylbilane synthase	Rattus norvegicus	73-98
1418238-1	1992	This report demonstrates the ability of folic acid to activate rat liver porphobilinogen-deaminase (PBG-D).	Folic Acid	40-50	hydroxymethylbilane synthase	Rattus norvegicus	100-105
1418238-3	1992	In the concentration range assayed, secondary replots of 1/delta slope and 1/delta intersect versus 1/[folic acid] yielded straight lines, indicating the binding of a single molecule of activator to the enzyme PBG-D, with a KA = 1.66 mM.	Folic Acid	103-113	hydroxymethylbilane synthase	Rattus norvegicus	210-215
1418238-5	1992	The activating effect of folic acid has been observed employing the 35-70% ammonium sulphate precipitated fraction, desalted by dialysis or gel filtration, whereas no action was detected when other partially purified PBG-D preparations were utilized as the enzyme source, suggesting either the presence of sites saturated for the activator, or the existence of a different structural protein conformation, or both.	Folic Acid	25-35	hydroxymethylbilane synthase	Rattus norvegicus	217-222
1529671-1	1992	Dihydrofolate reductase (DHFR, EC 1.5.1.3) is an enzyme involved in the metabolism of nucleic acids; it is also an important target for folate antagonists such as methotrexate (MTX).	Folic Acid	7-13	dihydrofolate reductase	Homo sapiens	25-29
1299378-1	1992	Folate-binding protein (FBP), a high-affinity folate receptor expressed in certain malignant and normal cell lines and tissues, is responsible for cellular transport of folate and structurally related antifolates such as methotrexate in human KB (nasopharyngeal carcinoma) cells.	Folic Acid	46-52	folate receptor alpha	Homo sapiens	0-22
1299378-1	1992	Folate-binding protein (FBP), a high-affinity folate receptor expressed in certain malignant and normal cell lines and tissues, is responsible for cellular transport of folate and structurally related antifolates such as methotrexate in human KB (nasopharyngeal carcinoma) cells.	Folic Acid	46-52	folate receptor alpha	Homo sapiens	24-27
1768284-3	1991	The significantly lower activity of both compounds under folate-independent conditions indicated DHFR as the primary target.	Folic Acid	57-63	dihydrofolate reductase	Homo sapiens	97-101
1897982-2	1991	A radioenzymatic assay based upon entrapment of 5,10-methylenetetrahydrofolate, and other reduced folates after cycling to this form, into a stable ternary complex with thymidylate synthase and tritiated 5-fluoro-2"-deoxyuridine-5"-monophosphate was used to estimate reduced folate metabolites.	Folic Acid	98-105	thymidylate synthetase	Homo sapiens	169-189
1897982-2	1991	A radioenzymatic assay based upon entrapment of 5,10-methylenetetrahydrofolate, and other reduced folates after cycling to this form, into a stable ternary complex with thymidylate synthase and tritiated 5-fluoro-2"-deoxyuridine-5"-monophosphate was used to estimate reduced folate metabolites.	Folic Acid	72-78	thymidylate synthetase	Homo sapiens	169-189
1988122-16	1991	HD-MTX induced a temporary intracellular folate depletion before 5-formyl-tetrahydrofolate was administered, as judged by a transient homocysteinemia.	Folic Acid	41-47	metaxin 1	Homo sapiens	3-6
2178951-7	1990	Anti-folates commonly used to treat microbial infections are poor inhibitors of L. major DHFR.	Folic Acid	5-12	dihydrofolate reductase	Homo sapiens	89-93
2180768-10	1990	Interestingly, pyrimethamine-resistant strains of P. falciparum all have a common point mutation in the DHFR coding sequence (Thr/Ser 108 to Asn), which causes decreased binding of the folate analog.	Folic Acid	185-191	dihydrofolate reductase	Homo sapiens	104-108
2195551-3	1990	Reduced folates (LV and 5-methyltetrahydrofolate) at concentrations greater than or equal to 1 microM can, by raising the intracellular levels of 5,10-methylenetetrahydrofolate, increase and prolong the inhibition of the target enzyme, thymidylate synthase, with formation of a stable ternary complex formed by the enzyme, the folate coenzyme and the fluoropyrimidine inhibitor (5-fluorodeoxyuridylate).	Folic Acid	8-15	thymidylate synthetase	Homo sapiens	236-256
34805245-0	2021	Dietary Folic Acid Alters Metabolism of Multiple Vitamins in a CerS6- and Sex-Dependent Manner.	Folic Acid	8-18	ceramide synthase 6	Mus musculus	63-68
10487535-1	1999	Studies are reported that describe the multifaceted inhibitory effects of prostaglandin A1 (PGA1) on processes that govern the transport of folates across the plasma membrane of Chinese hamster ovary (CHO) cells: the reduced folate carrier, RFC1, and ATP-dependent exporters.	Folic Acid	140-147	replication factor C subunit 1	Cricetulus griseus	241-245
10528109-0	1999	Toxicity induced by a polyglutamated folate analog is attenuated by NAALADase inhibition.	Folic Acid	37-43	folate hydrolase 1	Rattus norvegicus	68-77
10570974-1	1999	Gamma-glutamyl hydrolase (GH) plays an important role in the metabolism of folic acid and the pharmacology of antifolates such as methotrexate.	Folic Acid	75-85	gamma-glutamyl hydrolase	Homo sapiens	0-24
10570974-1	1999	Gamma-glutamyl hydrolase (GH) plays an important role in the metabolism of folic acid and the pharmacology of antifolates such as methotrexate.	Folic Acid	75-85	gamma-glutamyl hydrolase	Homo sapiens	26-28
10507318-4	1999	Another MTX-resistant subline with impaired reduced folate carrier (MOLT-3/MTX10,000) also showed overexpression of FPGS mRNA.	Folic Acid	52-58	folylpolyglutamate synthase	Homo sapiens	116-120
10446858-8	1999	Furthermore, the FR-beta protein was shown to have folic acid binding capacity.	Folic Acid	51-61	folate receptor beta	Homo sapiens	17-24
10393262-0	1999	The effect of folate deficiency on the hprt mutational spectrum in Chinese hamster ovary cells treated with monofunctional alkylating agents.	Folic Acid	14-20	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	39-43
10341130-3	1999	The methods are implemented experimentally using the complex of molecules composed of the enzyme Escherichia coli dihydrofolate reductase (DHFR) and the ligand folate.	Folic Acid	121-127	Dihydrofolate reductase	Escherichia coli	139-143
10341130-4	1999	In an equilibrium solution with DHFR, folate is known to undergo chemical exchange between a free state and a bound state.	Folic Acid	38-44	Dihydrofolate reductase	Escherichia coli	32-36
10102280-8	1999	A heterologous functional expression assay using MTX(R)-ZR-75-1 cells showed that the folate receptor alpha cDNA obtained by RT-PCR from the RPE/choroid complex and the neural retina was functional as assessed by the binding of folic acid and by the uptake of N5-methyltetrahydrofolate.	Folic Acid	228-238	folate receptor 1 (adult)	Mus musculus	86-107
10222796-1	1999	The folate sensitive fragile site FRAXE is located in Xq28, 600 kb distal to the fragile X syndrome (FRAXA) fragile site.	Folic Acid	4-10	fragile site, folic acid type, rare, fra(X)(q28) E	Homo sapiens	34-39
10598558-1	1999	Prior studies have indicated that MTA requires intracellular polyglutamation for optimal cytotoxic effect and that these polyglutamates potently inhibit several key enzymes of folate metabolism, including thymidylate synthase (TS), dihydrofolate reductase, and glycinamide ribonucleotide formyltransferase (GARFT).	Folic Acid	176-182	thymidylate synthetase	Homo sapiens	205-225
9952321-1	1999	Folic acid (PteGlu)-enhanced intense synergy has been observed between nonpolyglutamylatable dihydrofolate reductase (DHFR) inhibitors and polyglutamylatable inhibitors of other folate-requiring enzymes, such as glycinamide ribonucleotide formyltransferase (GARFT) and thymidylate synthase.	Folic Acid	0-10	dihydrofolate reductase	Homo sapiens	93-116
9952321-1	1999	Folic acid (PteGlu)-enhanced intense synergy has been observed between nonpolyglutamylatable dihydrofolate reductase (DHFR) inhibitors and polyglutamylatable inhibitors of other folate-requiring enzymes, such as glycinamide ribonucleotide formyltransferase (GARFT) and thymidylate synthase.	Folic Acid	0-10	dihydrofolate reductase	Homo sapiens	118-122
9952321-1	1999	Folic acid (PteGlu)-enhanced intense synergy has been observed between nonpolyglutamylatable dihydrofolate reductase (DHFR) inhibitors and polyglutamylatable inhibitors of other folate-requiring enzymes, such as glycinamide ribonucleotide formyltransferase (GARFT) and thymidylate synthase.	Folic Acid	0-10	thymidylate synthetase	Homo sapiens	269-289
9952321-1	1999	Folic acid (PteGlu)-enhanced intense synergy has been observed between nonpolyglutamylatable dihydrofolate reductase (DHFR) inhibitors and polyglutamylatable inhibitors of other folate-requiring enzymes, such as glycinamide ribonucleotide formyltransferase (GARFT) and thymidylate synthase.	Folic Acid	12-18	dihydrofolate reductase	Homo sapiens	93-116
9952321-1	1999	Folic acid (PteGlu)-enhanced intense synergy has been observed between nonpolyglutamylatable dihydrofolate reductase (DHFR) inhibitors and polyglutamylatable inhibitors of other folate-requiring enzymes, such as glycinamide ribonucleotide formyltransferase (GARFT) and thymidylate synthase.	Folic Acid	12-18	dihydrofolate reductase	Homo sapiens	118-122
9952321-1	1999	Folic acid (PteGlu)-enhanced intense synergy has been observed between nonpolyglutamylatable dihydrofolate reductase (DHFR) inhibitors and polyglutamylatable inhibitors of other folate-requiring enzymes, such as glycinamide ribonucleotide formyltransferase (GARFT) and thymidylate synthase.	Folic Acid	12-18	thymidylate synthetase	Homo sapiens	269-289
9952321-9	1999	At 40 microM PteGlu, the intensity of the combined action in all cell lines was increased However, the most intense Loewe synergy was seen with HCT-8, HCT-8/DF2, H460, FaDu, A253, and Hep-2/500 cells, whereas the HCT-8/50 subculture showed less of the phenomenon, and PteGlu enhancement was the least with HCT-8/DW2, a subline deficient in folylpolyglutamate synthetase (FPGS).	Folic Acid	13-19	folylpolyglutamate synthase	Homo sapiens	340-369
9952321-9	1999	At 40 microM PteGlu, the intensity of the combined action in all cell lines was increased However, the most intense Loewe synergy was seen with HCT-8, HCT-8/DF2, H460, FaDu, A253, and Hep-2/500 cells, whereas the HCT-8/50 subculture showed less of the phenomenon, and PteGlu enhancement was the least with HCT-8/DW2, a subline deficient in folylpolyglutamate synthetase (FPGS).	Folic Acid	13-19	folylpolyglutamate synthase	Homo sapiens	371-375
9952321-11	1999	Impaired FPGS activity and low-folate adaptation prior to treatment significantly lessen the degree of PteGlu enhancement.	Folic Acid	103-109	folylpolyglutamate synthase	Homo sapiens	9-13
10092996-5	1999	The plasma levels of cysteinylglycine and vitamin B12 correlated positively with circulating E-selectin and VCAM-1, respectively, whereas folate in serum and blood correlated negatively with P-selectin.	Folic Acid	138-144	selectin P	Homo sapiens	191-201
9987069-5	1999	METHODS: Tissue HGF and c-met mRNA levels were detected by RNase protection assay and Northern blot analysis following acute renal injury induced by a single injection of folic acid.	Folic Acid	171-181	met proto-oncogene	Mus musculus	24-29
9987069-8	1999	RESULTS: Extremely rapid induction of renal HGF and c-met mRNA was observed beginning one hour following injection of folic acid.	Folic Acid	118-128	met proto-oncogene	Mus musculus	52-57
10470377-10	1999	Mitochondrial FPGS activity is required for mitochondrial folate accumulation, and cells lacking this isozyme are auxotrophic for glycine.	Folic Acid	58-64	folylpolyglutamate synthase	Homo sapiens	14-18
10470377-18	1999	The cytotoxic efficacy of other folate antagonists that are transported into the mitochondria was enhanced by mitochondrial FPGS activity, even when their loci of inhibition was a cytosolic enzyme.	Folic Acid	32-38	folylpolyglutamate synthase	Homo sapiens	124-128
10449919-5	1999	Fluorescence in situ hybridization studies on the first patient placed the two breakpoints near the folate-sensitive fragile sites FRA11A and FRA11B.	Folic Acid	100-106	fragile site, folic acid type, rare, fra(11)(q13.3)	Homo sapiens	131-137
10449919-5	1999	Fluorescence in situ hybridization studies on the first patient placed the two breakpoints near the folate-sensitive fragile sites FRA11A and FRA11B.	Folic Acid	100-106	Cbl proto-oncogene	Homo sapiens	142-148
9668089-5	1998	The folic acid influx Ki in L1210 cells was more than 50-fold greater than that of MTX based upon inhibition of 5-CHO-THF influx.	Folic Acid	4-14	thin fur	Mus musculus	118-121
9647673-1	1998	Folylpolyglutamate synthetase (FPGS) catalyzes anATP-dependent ligation reaction that results in the synthesis of poly(gamma-glutamate) metabolites of folates and some antifolates.	Folic Acid	151-158	folylpolyglutamate synthase	Homo sapiens	0-29
9647673-1	1998	Folylpolyglutamate synthetase (FPGS) catalyzes anATP-dependent ligation reaction that results in the synthesis of poly(gamma-glutamate) metabolites of folates and some antifolates.	Folic Acid	151-158	folylpolyglutamate synthase	Homo sapiens	31-35
9647673-9	1998	]glutarate</compound-id> is also an analog of a proposed tetrahedral intermediate in the reaction catalyzed by gamma-glutamyl hydrolase (gamma-GH), another enzyme of importance in controlling folate homeostasis in cells.	Folic Acid	192-198	gamma-glutamyl hydrolase	Homo sapiens	111-135
9647673-9	1998	]glutarate</compound-id> is also an analog of a proposed tetrahedral intermediate in the reaction catalyzed by gamma-glutamyl hydrolase (gamma-GH), another enzyme of importance in controlling folate homeostasis in cells.	Folic Acid	192-198	gamma-glutamyl hydrolase	Homo sapiens	137-145
10499129-2	1998	In this application, pulsed ultrafiltration conditions were optimized for the isolation and identification of inhibitors of dihydrofolate reductase from a 22 compound library containing six known inhibitors of the enzyme including trimethoprim, aminopterin, methotrexate, pyrimethamine, folic acid, and folinic acid, and 16 compounds without known affinity.	Folic Acid	287-297	dihydrofolate reductase	Homo sapiens	124-147
9638660-15	1998	Determinations of folates and organic acids in CSF appear at present only warrantable individually in special constellations, e.g. classical clinical findings and disease course suggestive of glutaryl-CoA dehydrogenase deficiency with repeated negative quantitative analyses of organic acids in urine.	Folic Acid	18-25	colony stimulating factor 2	Homo sapiens	47-50
9436180-5	1998	TS inhibitors nonstructural analog of folate, non-analog antifolate inhibitors (NAAI), are welcome as a new interesting research topic.	Folic Acid	38-44	thymidylate synthetase	Homo sapiens	0-2
9436180-6	1998	Among the most recent and interesting ones, compounds from Agouron related to the indole structure, are independent on the folate metabolism, highly active and specific for human TS.	Folic Acid	123-129	thymidylate synthetase	Homo sapiens	179-181
9436180-8	1998	The x-ray crystal structures of some of these inhibitors with TS show that they bind in a different binding site from that of the classical folate TS inhibitors.	Folic Acid	140-146	thymidylate synthetase	Homo sapiens	62-64
9436180-8	1998	The x-ray crystal structures of some of these inhibitors with TS show that they bind in a different binding site from that of the classical folate TS inhibitors.	Folic Acid	140-146	thymidylate synthetase	Homo sapiens	147-149
9479873-8	1997	Selective inhibitors of TS with a folate structure such as raltitrexed could circumvent the resistance by virtue of DHFR overproduction, and this class of compounds which have higher substrate activities for FPGS than MTX may be of value for the treatment of myeloid leukemias in addition to lymphocytic malignancies resistant to conventional chemotherapy.	Folic Acid	34-40	thymidylate synthetase	Homo sapiens	24-26
9479873-8	1997	Selective inhibitors of TS with a folate structure such as raltitrexed could circumvent the resistance by virtue of DHFR overproduction, and this class of compounds which have higher substrate activities for FPGS than MTX may be of value for the treatment of myeloid leukemias in addition to lymphocytic malignancies resistant to conventional chemotherapy.	Folic Acid	34-40	dihydrofolate reductase	Homo sapiens	116-120
9479873-8	1997	Selective inhibitors of TS with a folate structure such as raltitrexed could circumvent the resistance by virtue of DHFR overproduction, and this class of compounds which have higher substrate activities for FPGS than MTX may be of value for the treatment of myeloid leukemias in addition to lymphocytic malignancies resistant to conventional chemotherapy.	Folic Acid	34-40	folylpolyglutamate synthase	Homo sapiens	208-212
34727921-11	2021	Finally six hub genes of PGA were identified, including ADCY2, CXCL1, FPRL1, GPR109B, GPR109A and ADCY3, which were validated in a separate dataset of GSE137268.	Folic Acid	25-28	formyl peptide receptor 2	Homo sapiens	70-75
34727921-11	2021	Finally six hub genes of PGA were identified, including ADCY2, CXCL1, FPRL1, GPR109B, GPR109A and ADCY3, which were validated in a separate dataset of GSE137268.	Folic Acid	25-28	hydroxycarboxylic acid receptor 3	Homo sapiens	77-84
34829516-4	2021	Moreover, dihydrofolate reductase (DHFR), a key enzyme in folate-mediated metabolism, exhibited impaired activity and decreased protein expression in CRIF1 knockdown endothelial cells.	Folic Acid	58-64	dihydrofolate reductase	Homo sapiens	10-33
34829516-4	2021	Moreover, dihydrofolate reductase (DHFR), a key enzyme in folate-mediated metabolism, exhibited impaired activity and decreased protein expression in CRIF1 knockdown endothelial cells.	Folic Acid	58-64	dihydrofolate reductase	Homo sapiens	35-39
34666844-0	2021	Altered dietary ratio of folic acid and vitamin B12 during pregnancy influences the expression of imprinted H19/IGF2 locus in C57BL/6 mice.	Folic Acid	25-35	insulin-like growth factor 2	Mus musculus	112-116
34666844-2	2021	This study elucidated the effect of altered dietary ratio of folic acid and B12 on the regulation of H19/IGF2 locus in C57BL/6 mice.	Folic Acid	61-71	insulin-like growth factor 2	Mus musculus	105-109
34666844-7	2021	Insulin-like growth factor 2 (IGF2), expression was decreased under folic acid deficient conditions combined with normal, deficient or over-supplemented state of B12 (BNFD, BDFD, BOFD) in fetal tissues along with B12 deficiency combined with normal folic acid (BDFN) in the placenta.	Folic Acid	68-78	insulin-like growth factor 2	Mus musculus	0-28
34666844-7	2021	Insulin-like growth factor 2 (IGF2), expression was decreased under folic acid deficient conditions combined with normal, deficient or over-supplemented state of B12 (BNFD, BDFD, BOFD) in fetal tissues along with B12 deficiency combined with normal folic acid (BDFN) in the placenta.	Folic Acid	68-78	insulin-like growth factor 2	Mus musculus	30-34
34666844-11	2021	Results suggest that the altered dietary ratio of folic acid and B12 affects the in-utero development of the fetus in association with altered epigenetic regulation of H19/IGF2 locus.	Folic Acid	50-60	insulin-like growth factor 2	Mus musculus	172-176
9393711-8	1997	In addition, this SHMT also catalyzed the cleavage of both allo-threonine and beta-phenylserine in the absence of the modified folate.	Folic Acid	127-133	SULB_RS08175	Saccharolobus solfataricus	18-22
9284325-3	1997	The present work uses molecular dynamics simulations to explore the effects of replacement of tryptophan by 6-fluorotryptophan in folate and methotrexate complexes of the enzyme dihydrofolate reductase (DHFR) (Escherichia coli).	Folic Acid	130-136	Dihydrofolate reductase	Escherichia coli	178-201
9284325-3	1997	The present work uses molecular dynamics simulations to explore the effects of replacement of tryptophan by 6-fluorotryptophan in folate and methotrexate complexes of the enzyme dihydrofolate reductase (DHFR) (Escherichia coli).	Folic Acid	130-136	Dihydrofolate reductase	Escherichia coli	203-207
9815766-1	1997	ZD9331 is a drug that was developed from a potent class of water-soluble, C7-methyl-substituted, quinazoline-based inhibitors of thymidylate synthase (TS) that are transported into cells via a saturable, carrier-mediated system (reduced folate carrier, or RFC) but are not substrates for folylpolyglutamate synthetase.	Folic Acid	237-243	thymidylate synthetase	Homo sapiens	129-149
9815719-2	1997	Optimal cellular concentrations of reduced folates in polyglutamated forms [via folylpolyglutamate synthetase (FPGS)] are necessary for achieving maximal TS inhibition.	Folic Acid	43-50	folylpolyglutamate synthase	Homo sapiens	80-109
9815719-2	1997	Optimal cellular concentrations of reduced folates in polyglutamated forms [via folylpolyglutamate synthetase (FPGS)] are necessary for achieving maximal TS inhibition.	Folic Acid	43-50	folylpolyglutamate synthase	Homo sapiens	111-115
9054377-0	1997	Posttranscriptionally mediated decreases in folylpolyglutamate synthetase gene expression in some folate analogue-resistant variants of the L1210 cell.	Folic Acid	98-104	folylpolyglutamyl synthetase	Mus musculus	44-73
8988912-3	1997	We investigated the effect of isolated folate deficiency in rats on DNA methylation and DNA strand breaks both at the genomic level and within specific sequences of the p53 tumor suppressor gene.	Folic Acid	39-45	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	169-172
9066627-0	1997	Folic acid-polylysine carrier improves efficacy of c-myc antisense oligodeoxynucleotides on human melanoma (M14) cells.	Folic Acid	0-10	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	51-56
9012448-1	1997	Mutations in the enzyme dihydrofolate reductase (DHFR) can confer resistance to the inhibitory effects of folate analogs such as methotrexate (Mtx) and trimetrexate (Ttx).	Folic Acid	31-37	dihydrofolate reductase	Homo sapiens	49-53
8978793-2	1996	Methotrexate tightly binds to dihydrofolate reductase (DHFR), blocking the reduction of dihydrofolate to tetrahydrofolic acid, the active form of folic acid.	Folic Acid	115-125	dihydrofolate reductase	Homo sapiens	30-53
8978793-2	1996	Methotrexate tightly binds to dihydrofolate reductase (DHFR), blocking the reduction of dihydrofolate to tetrahydrofolic acid, the active form of folic acid.	Folic Acid	115-125	dihydrofolate reductase	Homo sapiens	55-59
8978794-2	1996	We know much more about MTX and its molecular and cellular pharmacology and mechanisms of anti-cancer action in light of current knowledge of the biochemistry of folate.	Folic Acid	162-168	metaxin 1	Homo sapiens	24-27
8937460-5	1996	In response to restricted dietary folate, four out of five tissues had significantly increased (25-50%) FPGS activity.	Folic Acid	34-40	folylpolyglutamyl synthetase	Mus musculus	104-108
8937460-7	1996	The results indicate that changes in dietary folate intake can modulate FPGS activity significantly in vivo and suggest that the tissue distribution and toxicities of classical antifolates requiring polyglutamation for activation and cellular retention will be influenced significantly by folate status of the host.	Folic Acid	45-51	folylpolyglutamyl synthetase	Mus musculus	72-76
8937460-7	1996	The results indicate that changes in dietary folate intake can modulate FPGS activity significantly in vivo and suggest that the tissue distribution and toxicities of classical antifolates requiring polyglutamation for activation and cellular retention will be influenced significantly by folate status of the host.	Folic Acid	181-187	folylpolyglutamyl synthetase	Mus musculus	72-76
9634824-5	1996	Therefore, we conjugated folate to the neutralizing Fab fragment of an anti-fiber monoclonal antibody.	Folic Acid	25-31	FA complementation group B	Homo sapiens	52-55
8913793-1	1996	MX-68 is a newly synthesized anti-folate, chemically designed not to undergo intracellular polyglutamation and to have increased affinity to dihydrofolate reductase (DHFR).	Folic Acid	34-40	dihydrofolate reductase	Homo sapiens	166-170
34665710-1	2021	OBJECTIVES: Methotrexate (MTX)is a folate antagonist that is administered in several conditions such as rheumatoid arthritis.	Folic Acid	35-41	metaxin 1	Homo sapiens	26-29
34665710-3	2021	Although MTX side effects could be decreased by folate supplementation, the current guideline on folate administration is not precisely established, which could result in irreversible damage especially in high-risk groups like women in childbearing-age.	Folic Acid	48-54	metaxin 1	Homo sapiens	9-12
34665710-3	2021	Although MTX side effects could be decreased by folate supplementation, the current guideline on folate administration is not precisely established, which could result in irreversible damage especially in high-risk groups like women in childbearing-age.	Folic Acid	97-103	metaxin 1	Homo sapiens	9-12
34665710-4	2021	Thus, this study aimed to investigate the in vitro rescuing effect of different folates including folic acid (FA), 5-methyltetrahydrofolate (MTHF) and folinic acid (5-Formyltetrahydrofolic acid, FTHF) on MTX-treated trophoblast cells.	Folic Acid	80-87	metaxin 1	Homo sapiens	204-207
34665710-4	2021	Thus, this study aimed to investigate the in vitro rescuing effect of different folates including folic acid (FA), 5-methyltetrahydrofolate (MTHF) and folinic acid (5-Formyltetrahydrofolic acid, FTHF) on MTX-treated trophoblast cells.	Folic Acid	98-108	metaxin 1	Homo sapiens	204-207
34390827-1	2021	Activated macrophages overexpress the folate receptor beta (FR-beta) that can be used for targeted delivery of drugs conjugated to folic acid.	Folic Acid	131-141	folate receptor beta	Homo sapiens	38-58
34390827-1	2021	Activated macrophages overexpress the folate receptor beta (FR-beta) that can be used for targeted delivery of drugs conjugated to folic acid.	Folic Acid	131-141	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	60-67
34390827-6	2021	We conjugated a potent mPGES-1 inhibitor, MK-7285, to folate, but the construct released the drug inefficiently.	Folic Acid	54-60	prostaglandin E synthase	Mus musculus	23-30
34647497-4	2021	The expression of miR-31 was positively associated with the consumption of iron (beta = 16.65) and vitamin C (beta = 0.37), and inversely associated with total sugar (beta = -0.88), cholesterol (beta= -0.23), vitamin B9 (beta= -0.37) and zinc (beta = -5.66) intake.	Folic Acid	209-219	microRNA 31	Homo sapiens	18-24
34692767-12	2021	Folic acid alleviated HGF-induced cell damage in vitro and in vivo by decreasing activation of the Hippo pathway, as indicated by lower LDH release and increased cell viability, and decreased expression of NLRP3, ASC, cleaved caspase-1, IL-1beta, IL-18, p-YAP and p-LATS.	Folic Acid	0-10	NLR family, pyrin domain containing 3	Mus musculus	206-211
34692767-12	2021	Folic acid alleviated HGF-induced cell damage in vitro and in vivo by decreasing activation of the Hippo pathway, as indicated by lower LDH release and increased cell viability, and decreased expression of NLRP3, ASC, cleaved caspase-1, IL-1beta, IL-18, p-YAP and p-LATS.	Folic Acid	0-10	interleukin 1 alpha	Mus musculus	237-245
34185885-5	2021	In addition, the therapeutic efficacy of phototherapy against MC903-driven AD could be increased with prior application of folate, which photodegrades into the inhibitory MR1 ligand 6-formylpterin.	Folic Acid	123-129	major histocompatibility complex, class I-related	Mus musculus	171-174
34289180-6	2021	Our results lead to a new hypothesis that a lower activity of FPGS enzyme reduces intracellular folate levels and increases the risk of an offspring having NSCL/P.	Folic Acid	96-102	folylpolyglutamate synthase	Homo sapiens	62-66
34474604-0	2021	Folic acid deficiency damages male reproduction via endoplasmic reticulum stress-associated PERK pathway induced by Caveolin-1 in mice.	Folic Acid	0-10	caveolin 1, caveolae protein	Mus musculus	116-126
34474604-7	2021	Meanwhile, folic acid deficiency decreased Cav-1 expression in the testis tissue and increased endoplasmic reticulum stress-related PERK, eIF2alpha, ATF4, CHOP gene expression.	Folic Acid	11-21	caveolin 1, caveolae protein	Mus musculus	43-48
34474604-7	2021	Meanwhile, folic acid deficiency decreased Cav-1 expression in the testis tissue and increased endoplasmic reticulum stress-related PERK, eIF2alpha, ATF4, CHOP gene expression.	Folic Acid	11-21	DNA-damage inducible transcript 3	Mus musculus	155-159
34474604-8	2021	Our results suggest that folic acid deficiency can affect male reproduction through the Cav-1-PERK-eIFalpha-ATF4-CHOP pathway.Abbreviations: ATF4: activating transcription factor 4; Ca2+: calcium ion; Cav-1: Caveolin-1; CCK-8: cell counting kit-8; CHOP: CCAAT-enhancer-binding protein homologous protein; DNA: Deoxyribonucleic acid; DSB: double strand breakage; eIF2alpha: eukaryotic Initiation Factor 2 alpha; ER: endoplasmic reticulum; FD: folic acid deficiency; FITC: fluorescein isothiocyanate; HE: hematoxylin and eosin; H3K4me3: histone H3 lysine 4 trimethylation; PERK: protein kinase RNA-like endoplasmic reticulum kinase; PI: propidium iodide; RT-qPCR: quantitative reverse transcription PCR; TUNEL: TdT mediated dUTP Nick End Labeling.	Folic Acid	25-35	caveolin 1, caveolae protein	Mus musculus	88-93
34474604-8	2021	Our results suggest that folic acid deficiency can affect male reproduction through the Cav-1-PERK-eIFalpha-ATF4-CHOP pathway.Abbreviations: ATF4: activating transcription factor 4; Ca2+: calcium ion; Cav-1: Caveolin-1; CCK-8: cell counting kit-8; CHOP: CCAAT-enhancer-binding protein homologous protein; DNA: Deoxyribonucleic acid; DSB: double strand breakage; eIF2alpha: eukaryotic Initiation Factor 2 alpha; ER: endoplasmic reticulum; FD: folic acid deficiency; FITC: fluorescein isothiocyanate; HE: hematoxylin and eosin; H3K4me3: histone H3 lysine 4 trimethylation; PERK: protein kinase RNA-like endoplasmic reticulum kinase; PI: propidium iodide; RT-qPCR: quantitative reverse transcription PCR; TUNEL: TdT mediated dUTP Nick End Labeling.	Folic Acid	25-35	DNA-damage inducible transcript 3	Mus musculus	113-117
34474604-8	2021	Our results suggest that folic acid deficiency can affect male reproduction through the Cav-1-PERK-eIFalpha-ATF4-CHOP pathway.Abbreviations: ATF4: activating transcription factor 4; Ca2+: calcium ion; Cav-1: Caveolin-1; CCK-8: cell counting kit-8; CHOP: CCAAT-enhancer-binding protein homologous protein; DNA: Deoxyribonucleic acid; DSB: double strand breakage; eIF2alpha: eukaryotic Initiation Factor 2 alpha; ER: endoplasmic reticulum; FD: folic acid deficiency; FITC: fluorescein isothiocyanate; HE: hematoxylin and eosin; H3K4me3: histone H3 lysine 4 trimethylation; PERK: protein kinase RNA-like endoplasmic reticulum kinase; PI: propidium iodide; RT-qPCR: quantitative reverse transcription PCR; TUNEL: TdT mediated dUTP Nick End Labeling.	Folic Acid	25-35	caveolin 1, caveolae protein	Mus musculus	201-206
34474604-8	2021	Our results suggest that folic acid deficiency can affect male reproduction through the Cav-1-PERK-eIFalpha-ATF4-CHOP pathway.Abbreviations: ATF4: activating transcription factor 4; Ca2+: calcium ion; Cav-1: Caveolin-1; CCK-8: cell counting kit-8; CHOP: CCAAT-enhancer-binding protein homologous protein; DNA: Deoxyribonucleic acid; DSB: double strand breakage; eIF2alpha: eukaryotic Initiation Factor 2 alpha; ER: endoplasmic reticulum; FD: folic acid deficiency; FITC: fluorescein isothiocyanate; HE: hematoxylin and eosin; H3K4me3: histone H3 lysine 4 trimethylation; PERK: protein kinase RNA-like endoplasmic reticulum kinase; PI: propidium iodide; RT-qPCR: quantitative reverse transcription PCR; TUNEL: TdT mediated dUTP Nick End Labeling.	Folic Acid	25-35	caveolin 1, caveolae protein	Mus musculus	208-218
34474604-8	2021	Our results suggest that folic acid deficiency can affect male reproduction through the Cav-1-PERK-eIFalpha-ATF4-CHOP pathway.Abbreviations: ATF4: activating transcription factor 4; Ca2+: calcium ion; Cav-1: Caveolin-1; CCK-8: cell counting kit-8; CHOP: CCAAT-enhancer-binding protein homologous protein; DNA: Deoxyribonucleic acid; DSB: double strand breakage; eIF2alpha: eukaryotic Initiation Factor 2 alpha; ER: endoplasmic reticulum; FD: folic acid deficiency; FITC: fluorescein isothiocyanate; HE: hematoxylin and eosin; H3K4me3: histone H3 lysine 4 trimethylation; PERK: protein kinase RNA-like endoplasmic reticulum kinase; PI: propidium iodide; RT-qPCR: quantitative reverse transcription PCR; TUNEL: TdT mediated dUTP Nick End Labeling.	Folic Acid	25-35	DNA-damage inducible transcript 3	Mus musculus	248-252
34474604-8	2021	Our results suggest that folic acid deficiency can affect male reproduction through the Cav-1-PERK-eIFalpha-ATF4-CHOP pathway.Abbreviations: ATF4: activating transcription factor 4; Ca2+: calcium ion; Cav-1: Caveolin-1; CCK-8: cell counting kit-8; CHOP: CCAAT-enhancer-binding protein homologous protein; DNA: Deoxyribonucleic acid; DSB: double strand breakage; eIF2alpha: eukaryotic Initiation Factor 2 alpha; ER: endoplasmic reticulum; FD: folic acid deficiency; FITC: fluorescein isothiocyanate; HE: hematoxylin and eosin; H3K4me3: histone H3 lysine 4 trimethylation; PERK: protein kinase RNA-like endoplasmic reticulum kinase; PI: propidium iodide; RT-qPCR: quantitative reverse transcription PCR; TUNEL: TdT mediated dUTP Nick End Labeling.	Folic Acid	25-35	DNA-damage inducible transcript 3	Mus musculus	254-303
34474604-8	2021	Our results suggest that folic acid deficiency can affect male reproduction through the Cav-1-PERK-eIFalpha-ATF4-CHOP pathway.Abbreviations: ATF4: activating transcription factor 4; Ca2+: calcium ion; Cav-1: Caveolin-1; CCK-8: cell counting kit-8; CHOP: CCAAT-enhancer-binding protein homologous protein; DNA: Deoxyribonucleic acid; DSB: double strand breakage; eIF2alpha: eukaryotic Initiation Factor 2 alpha; ER: endoplasmic reticulum; FD: folic acid deficiency; FITC: fluorescein isothiocyanate; HE: hematoxylin and eosin; H3K4me3: histone H3 lysine 4 trimethylation; PERK: protein kinase RNA-like endoplasmic reticulum kinase; PI: propidium iodide; RT-qPCR: quantitative reverse transcription PCR; TUNEL: TdT mediated dUTP Nick End Labeling.	Folic Acid	25-35	deoxynucleotidyltransferase, terminal	Mus musculus	709-712
34603014-0	2021	Folate Reverses NF-kappaB p65/Rela/IL-6 Level Induced by Hyperhomocysteinemia in Spontaneously Hypertensive Rats.	Folic Acid	0-6	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	30-34
34603014-10	2021	Furthermore, folate inhibited the expression of IL-6 and NF-kappaB p65/Rela, reduced the levels of MDA and HHcy, but significantly increased the SOD level.	Folic Acid	13-19	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	71-75
34603014-12	2021	However, folate demonstrated anti-inflammatory properties and reversed the NF-kappaB p65/Rela/IL-6 level induced by HHcy in hypertensive rats.	Folic Acid	9-15	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	89-93
34412467-1	2021	As we all know, inhibiting the activity of dihydrofolate reductase (DHFR) has always been an effective strategy for folate antimetabolites to treat tumors.	Folic Acid	116-122	dihydrofolate reductase	Homo sapiens	43-66
34412467-1	2021	As we all know, inhibiting the activity of dihydrofolate reductase (DHFR) has always been an effective strategy for folate antimetabolites to treat tumors.	Folic Acid	116-122	dihydrofolate reductase	Homo sapiens	68-72
34378936-4	2021	Specifically, we designed a folate-caged pomalidomide prodrug, FA-S2-POMA, by incorporating a folate group as a caging and guiding element and validated its degradation effect on its neo-substrates in FOLR1-positive cancer cells in a FOLR1-dependent manner.	Folic Acid	28-34	folate receptor alpha	Homo sapiens	201-206
34378936-4	2021	Specifically, we designed a folate-caged pomalidomide prodrug, FA-S2-POMA, by incorporating a folate group as a caging and guiding element and validated its degradation effect on its neo-substrates in FOLR1-positive cancer cells in a FOLR1-dependent manner.	Folic Acid	28-34	folate receptor alpha	Homo sapiens	234-239
34378936-4	2021	Specifically, we designed a folate-caged pomalidomide prodrug, FA-S2-POMA, by incorporating a folate group as a caging and guiding element and validated its degradation effect on its neo-substrates in FOLR1-positive cancer cells in a FOLR1-dependent manner.	Folic Acid	94-100	folate receptor alpha	Homo sapiens	201-206
34378936-4	2021	Specifically, we designed a folate-caged pomalidomide prodrug, FA-S2-POMA, by incorporating a folate group as a caging and guiding element and validated its degradation effect on its neo-substrates in FOLR1-positive cancer cells in a FOLR1-dependent manner.	Folic Acid	94-100	folate receptor alpha	Homo sapiens	234-239
34378936-5	2021	We also developed a folate-caged pomalidomide-based anaplastic lymphoma kinase (ALK) PROTAC, FA-S2-MS4048, which effectively degraded ALK fusion proteins in cancer cells, again in a FOLR1-dependent manner.	Folic Acid	20-26	folate receptor alpha	Homo sapiens	182-187
34440885-1	2021	Since activated macrophages express a functional folate receptor beta (FRbeta), targeting this macrophage population with folate-linked drugs could increase selectivity to treat inflammatory diseases.	Folic Acid	122-128	folate receptor beta	Rattus norvegicus	49-69
34485245-4	2021	In this direction, we developed folate-functionalized DNA origami that effectively targets and delivers doxorubicin (DOX), a well-known anticancer drug to the folate receptor alpha (FOLR1) expressing triple-negative breast cancer (TNBC) cells in vitro.	Folic Acid	32-38	folate receptor alpha	Homo sapiens	159-180
34485245-4	2021	In this direction, we developed folate-functionalized DNA origami that effectively targets and delivers doxorubicin (DOX), a well-known anticancer drug to the folate receptor alpha (FOLR1) expressing triple-negative breast cancer (TNBC) cells in vitro.	Folic Acid	32-38	folate receptor alpha	Homo sapiens	182-187
34485245-5	2021	We show that folate-functionalized DNA origami structure targets and kills FOLR1 overexpressing cells with better efficacy than nontargeted origami.	Folic Acid	13-19	folate receptor alpha	Homo sapiens	75-80
8810903-8	1996	(2) This unique molecular structure can explain why GNMT can capture folate and polycyclic aromatic hydrocarbons.	Folic Acid	69-75	glycine N-methyltransferase	Rattus norvegicus	52-56
8888940-4	1996	Because the folate binding protein, located in the brush border membrane (BBM) of proximal tubule cells, is thought to be involved in renal folate reabsorption, the effects of ethanol on BBM binding of folate were assessed.	Folic Acid	140-146	folate receptor alpha	Homo sapiens	12-34
8764125-2	1996	Although it is an excellent substrate for the folate anabolizing enzyme folylpolyglutamate synthetase (FPGS), 1843U89 differs from other folate-based inhibitors of TS (e.g., CBC3717, D1694, and LY231514), in that the parent compound is as potent an enzyme inhibitor as its polyglutamated analogues.	Folic Acid	46-52	folylpolyglutamate synthase	Homo sapiens	72-101
8764125-2	1996	Although it is an excellent substrate for the folate anabolizing enzyme folylpolyglutamate synthetase (FPGS), 1843U89 differs from other folate-based inhibitors of TS (e.g., CBC3717, D1694, and LY231514), in that the parent compound is as potent an enzyme inhibitor as its polyglutamated analogues.	Folic Acid	46-52	folylpolyglutamate synthase	Homo sapiens	103-107
8844253-1	1996	The main objective of this study was to investigate the effects of pasteurisation, UHT processing and fermentation on the concentration of folate-binding proteins (FBP) and their folate binding capacity in comparison with the retention of the most predominant folate from, 5-CH3THF.	Folic Acid	139-145	folate receptor alpha	Homo sapiens	164-167
8844253-11	1996	Thus, heat processing of milk not only reduced the amount of 5-CH3 THF significantly, but also changed the concentration of FBP and the folate-binding capacity of FBP, which may have implications on the bioavailability of milk folates.	Folic Acid	136-142	folate receptor alpha	Homo sapiens	163-166
8844253-11	1996	Thus, heat processing of milk not only reduced the amount of 5-CH3 THF significantly, but also changed the concentration of FBP and the folate-binding capacity of FBP, which may have implications on the bioavailability of milk folates.	Folic Acid	227-234	folate receptor alpha	Homo sapiens	124-127
8844253-11	1996	Thus, heat processing of milk not only reduced the amount of 5-CH3 THF significantly, but also changed the concentration of FBP and the folate-binding capacity of FBP, which may have implications on the bioavailability of milk folates.	Folic Acid	227-234	folate receptor alpha	Homo sapiens	163-166
34392303-2	2021	Here, we characterized proximal tubular phenotype alternations during kidney injury and repair in a mouse model of folic acid nephropathy, in parallel, identified carnitine palmitoyltransferase 1alpha (CPT1alpha) as an energy stress response accompanied by renal tubular dedifferentiation.	Folic Acid	115-125	carnitine palmitoyltransferase 1a, liver	Mus musculus	202-211
34392303-5	2021	Interference of CPT1alpha reduced capacities of mitochondrial respiration and ATP production in PTECs, and further sensitized cells to folic acid-induced phenotypic changes.	Folic Acid	135-145	carnitine palmitoyltransferase 1a, liver	Mus musculus	16-25
34392303-6	2021	On the contrary, overexpression of CPT1alpha protected mitochondrial respiration and prevented against folic acid-induced tubular cell damage.	Folic Acid	103-113	carnitine palmitoyltransferase 1a, liver	Mus musculus	35-44
34247488-0	2021	Initial Stages of Spontaneous Binding of Folate-Based Vectors to Folate Receptor-alpha Observed by Unbiased Molecular Dynamics.	Folic Acid	41-47	folate receptor alpha	Homo sapiens	65-86
34247488-3	2021	A promising ligand-receptor pair is folic acid (or its dianionic form, folate) combined with the folate receptor-alpha (FRalpha).	Folic Acid	36-46	folate receptor alpha	Homo sapiens	97-118
34247488-3	2021	A promising ligand-receptor pair is folic acid (or its dianionic form, folate) combined with the folate receptor-alpha (FRalpha).	Folic Acid	36-46	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	120-127
34247488-3	2021	A promising ligand-receptor pair is folic acid (or its dianionic form, folate) combined with the folate receptor-alpha (FRalpha).	Folic Acid	71-77	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	120-127
34247488-5	2021	The current study summarizes the results from unbiased all-atom molecular dynamics simulations at physiological conditions describing the binding of two forms of folate and four of its synthetically available derivatives to FRalpha.	Folic Acid	162-168	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	224-231
34247488-12	2021	Two binding poses are observed, one of them (realized by raltitrexed) corresponding qualitatively to that reported for the crystallographic structure of the complex folate-FRalpha.	Folic Acid	165-171	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	172-179
34093861-0	2021	Site-specific glycoproteomic analysis revealing increased core-fucosylation on FOLR1 enhances folate uptake capacity of HCC cells to promote EMT.	Folic Acid	94-100	folate receptor alpha	Homo sapiens	79-84
34093861-9	2021	Finally, we confirmed that the level of core-fucosylation on FOLR1 especially at the glycosite Asn-201 positively regulated the cellular uptake capacity of folates, and enhanced uptake of folates could promote the EMT of HCC cells.	Folic Acid	156-163	folate receptor alpha	Homo sapiens	61-66
34093861-9	2021	Finally, we confirmed that the level of core-fucosylation on FOLR1 especially at the glycosite Asn-201 positively regulated the cellular uptake capacity of folates, and enhanced uptake of folates could promote the EMT of HCC cells.	Folic Acid	188-195	folate receptor alpha	Homo sapiens	61-66
35490796-3	2022	This study further investigated the ability of the methyl group donors, S-adenosyl methionine (SAM) and folic acid, to prevent promoter hypomethylation that results in decreased mRNA expression of inflammatory genes (COX2, EGR1, and SOCS3), and a reduction in arsenic-induced oxidative and nitrative DNA damage in human lymphoblast cells.	Folic Acid	104-114	early growth response 1	Homo sapiens	223-227
35238923-3	2022	Here, we report that sulfanilamide, an inhibitor of folate biosynthesis, delays flowering by repressing the expression of florigen FLOWERING LOCUS T (FT) in Arabidopsis thaliana.	Folic Acid	52-58	PEBP (phosphatidylethanolamine-binding protein) family protein	Arabidopsis thaliana	131-148
8698629-1	1996	The biological activity and cellular metabolism of ZD1694, a novel folate-based thymidylate synthase (TS) inhibitor, were analyzed in a human leukemia cell line, MOLT-3, and its antifolate-resistant sublines with different mechanisms of resistance to methotrexate (MTX), trimetrexate (TMQ) and N10-propargyl-5,8-dideazafolic acid (CB3717).	Folic Acid	67-73	thymidylate synthetase	Homo sapiens	80-100
8662720-12	1996	Mitochondrial FPGS activity is required for mitochondrial folate accumulation, while cytosolic FPGS activity is needed for establishment of normal cytosolic folate pools.	Folic Acid	58-64	folylpolyglutamate synthase	Homo sapiens	14-18
8662720-12	1996	Mitochondrial FPGS activity is required for mitochondrial folate accumulation, while cytosolic FPGS activity is needed for establishment of normal cytosolic folate pools.	Folic Acid	157-163	folylpolyglutamate synthase	Homo sapiens	95-99
8662720-13	1996	The reconstructed FPGS gene restored normal cytosolic and mitochondrial folate metabolism in hamster cells.	Folic Acid	72-78	folylpolyglutamate synthase	Homo sapiens	18-22
8691264-1	1996	UNLABELLED: Folate binding protein (FBP) GP38 is a membrane-associated glycoprotein that mediates the intracellular transport of folates.	Folic Acid	129-136	folate receptor alpha	Homo sapiens	12-34
8691264-1	1996	UNLABELLED: Folate binding protein (FBP) GP38 is a membrane-associated glycoprotein that mediates the intracellular transport of folates.	Folic Acid	129-136	folate receptor alpha	Homo sapiens	36-39
8608153-5	1996	Direct measurements of cellular folate coenzyme levels revealed substantial levels of 10-formyl-THF (CHO-THF), the one-carbon donor used in purine synthesis, in the purine-requiring ade3 deletion strain.	Folic Acid	32-38	trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase ADE3	Saccharomyces cerevisiae S288C	182-186
7796401-4	1995	Systematic structure-activity investigations have led to the discovery and development of ZD1694 (Tomudex), an inhibitor of thymidylate synthase that exploits both the reduced folate carrier and folylpolyglutamate synthetase as major determinants of its growth-inhibitory activity.	Folic Acid	176-182	thymidylate synthetase	Homo sapiens	124-144
7796401-6	1995	An associated structure-activity investigation has led to the development of ZD9331, a potent thymidylate synthase inhibitor which exploits the reduced folate carrier for cell entry, but which is independent of polyglutamation for its thymidylate synthase-inhibitory activity.	Folic Acid	152-158	thymidylate synthetase	Homo sapiens	94-114
7577040-1	1995	Thymidylate synthase is an important target for both fluorinated pyrimidines and for new folate analogues.	Folic Acid	89-95	thymidylate synthetase	Homo sapiens	0-20
7577040-3	1995	The 5FU-nucleotide FdUMP induces inhibition of thymidylate synthase which is enhanced and retained for longer in the presence of increased folate pools, for which leucovorin is a precursor.	Folic Acid	139-145	thymidylate synthetase	Homo sapiens	47-67
7783147-8	1995	Further evaluation of 9 against CCRF-CEM and its sublines having defined mechanisms of MTX resistance demonstrated that the analogue utilizes the reduced folate/MTX-transport system and primarily inhibits DHFR and poly-gamma-glutamylation plays a role in its mechanism of action.	Folic Acid	154-160	dihydrofolate reductase	Homo sapiens	205-209
7790120-5	1995	Folate binding to the membrane-associated folate-binding protein of KB cells was not affected by suramin.	Folic Acid	0-6	folate receptor alpha	Homo sapiens	42-64
7776369-7	1995	Structural comparison of the folate binding modes among GAR-Tfase, dihydrofolate reductase and thymidylate synthase reveals that folate derivates bound to GAR-Tfase differentially adopt the trans conformation for the dihedral angle between atoms C-6 and C-9 providing a handle for targeting specific folate-dependent enzymes.	Folic Acid	29-35	Dihydrofolate reductase	Escherichia coli	67-90
7537518-2	1995	A 500-fold increase in thymidylate synthase (TS) activity is the primary mechanism of resistance to ZD1694 in the W1L2:RD1694 cell line, which is consequently highly cross-resistant to other folate-based TS inhibitors, including BW1843U89, LY231514 and AG337, but sensitive to antifolates with other enzyme targets.	Folic Acid	191-197	thymidylate synthetase	Homo sapiens	23-43
7537519-0	1995	Molecular characterisation of two cell lines selected for resistance to the folate-based thymidylate synthase inhibitor, ZD1694.	Folic Acid	76-82	thymidylate synthetase	Homo sapiens	89-109
7537519-2	1995	We have investigated the mechanistic basis for resistance to folate-based thymidylate synthase (TS) inhibitors using two cell lines selected for resistance to ZD1694 (N-(5-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N -methylamino]-2 - thenoyl)-L-glutamic acid), a drug currently in phase III clinical trial.	Folic Acid	61-67	thymidylate synthetase	Homo sapiens	74-94
7537519-2	1995	We have investigated the mechanistic basis for resistance to folate-based thymidylate synthase (TS) inhibitors using two cell lines selected for resistance to ZD1694 (N-(5-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N -methylamino]-2 - thenoyl)-L-glutamic acid), a drug currently in phase III clinical trial.	Folic Acid	61-67	thymidylate synthetase	Homo sapiens	96-98
8852336-2	1995	The primary target of MTX is the enzyme dihydrofolate reductase (DHFR) which catalyzes the reduction of folate and 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate.	Folic Acid	47-53	dihydrofolate reductase	Homo sapiens	65-69
7893997-2	1994	Among the genes affected by folic acid treatment are the primary response genes, c-fos and c-myc, which are thought to function to initiate cell cycle events.	Folic Acid	28-38	FBJ osteosarcoma oncogene	Mus musculus	81-86
35561119-3	2022	For the first time, folate transport pathways (PCFT, RFC, and FRalpha) were examined in-depth as a potential mechanism of drug-induced folate deficiency and related toxicities (e.g., neural tube defects, megaloblastic anemia).	Folic Acid	20-26	solute carrier family 46 member 1	Homo sapiens	47-51
35561119-3	2022	For the first time, folate transport pathways (PCFT, RFC, and FRalpha) were examined in-depth as a potential mechanism of drug-induced folate deficiency and related toxicities (e.g., neural tube defects, megaloblastic anemia).	Folic Acid	20-26	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	62-69
35579178-10	2022	Next, high folate intake may decrease the risk of colon cancer (RR = 0.86, 95% CI: 0.81-0.92, P = 10-4) but not rectal cancer (RR = 0.92, 95% CI: 0.84-1.02, P = 0.112).	Folic Acid	11-17	natural killer cell triggering receptor	Homo sapiens	94-102
35438698-0	2022	Folic acid intervention changes liver Foxp3 methylation and ameliorates the damage caused by Th17/Treg imbalance after long-term alcohol exposure.	Folic Acid	0-10	forkhead box P3	Mus musculus	38-43
35438698-6	2022	The results showed that folic acid-inhibited ethanol-induced serum TG, TC, and LDL elevation attenuated hepatic fat accumulation and maintained ALT at a normal level.	Folic Acid	24-34	glutamic pyruvic transaminase, soluble	Mus musculus	144-147
35438698-10	2022	In summary, our findings demonstrated that folic acid supplementation may relieve ethanol-induced Th17/Treg disbalance through altering Foxp3 promoter methylation patterns, suggesting that folic acid may be a feasible preventive strategy for ALD.	Folic Acid	43-53	forkhead box P3	Mus musculus	136-141
35438698-10	2022	In summary, our findings demonstrated that folic acid supplementation may relieve ethanol-induced Th17/Treg disbalance through altering Foxp3 promoter methylation patterns, suggesting that folic acid may be a feasible preventive strategy for ALD.	Folic Acid	189-199	forkhead box P3	Mus musculus	136-141
35565057-11	2022	CMap-CTD database analyses indicated the expression levels of Tlr2, Ccl2, Cxcl10, Fas, Irf8, Socs3, Stat3, Gbp6, Casp1 and Syk could be reversed by folic acid.	Folic Acid	148-158	cystatin F	Homo sapiens	0-4
35565057-11	2022	CMap-CTD database analyses indicated the expression levels of Tlr2, Ccl2, Cxcl10, Fas, Irf8, Socs3, Stat3, Gbp6, Casp1 and Syk could be reversed by folic acid.	Folic Acid	148-158	C-C motif chemokine ligand 2	Homo sapiens	68-72
35565057-11	2022	CMap-CTD database analyses indicated the expression levels of Tlr2, Ccl2, Cxcl10, Fas, Irf8, Socs3, Stat3, Gbp6, Casp1 and Syk could be reversed by folic acid.	Folic Acid	148-158	interferon regulatory factor 8	Homo sapiens	87-91
35565057-11	2022	CMap-CTD database analyses indicated the expression levels of Tlr2, Ccl2, Cxcl10, Fas, Irf8, Socs3, Stat3, Gbp6, Casp1 and Syk could be reversed by folic acid.	Folic Acid	148-158	guanylate binding protein family member 6	Homo sapiens	107-111
35190897-0	2022	Folate ameliorates homocysteine-induced osteoblast dysfunction by reducing endoplasmic reticulum stress-activated PERK/ATF-4/CHOP pathway in MC3T3-E1 cells.	Folic Acid	0-6	DNA-damage inducible transcript 3	Mus musculus	125-129
35230979-4	2022	The abundance of Piezo1 protein in kidneys of mice with UUO or with folic-acid treatment was significantly increased.	Folic Acid	68-78	piezo-type mechanosensitive ion channel component 1	Mus musculus	17-23
35123312-8	2022	Supplementation of 50 muM folic acid in maturation medium improves oocyte maturation, the blastocyst production rate, reduces ROS production as well as upregulate the expression of FOLR1 and folate metabolism enzyme, MTR.	Folic Acid	26-36	folate receptor alpha	Homo sapiens	181-186
35040120-0	2022	A gamma-glutamyl hydrolase lacking the signal peptide confers susceptibility to folates/antifolates in acute lymphoblastic leukemia cells.	Folic Acid	80-87	gamma-glutamyl hydrolase	Homo sapiens	2-26
35040120-2	2022	gamma-Glutamyl hydrolase (GGH) catalyzes the removal of gamma-polyglutamate tails of folylpoly-/antifolylpoly-gamma-glutamates to facilitate their export out of the cell, thereby maintaining the metabolic homeostasis of folates or pharmacological efficacy of antifolates.	Folic Acid	220-227	gamma-glutamyl hydrolase	Homo sapiens	0-24
35040120-2	2022	gamma-Glutamyl hydrolase (GGH) catalyzes the removal of gamma-polyglutamate tails of folylpoly-/antifolylpoly-gamma-glutamates to facilitate their export out of the cell, thereby maintaining the metabolic homeostasis of folates or pharmacological efficacy of antifolates.	Folic Acid	220-227	gamma-glutamyl hydrolase	Homo sapiens	26-29
35040120-5	2022	In addition, ALL cells harboring GGH-DeltaN show high susceptibility to the change in folates, and glycosylation is not responsible for these phenotypes elicited by GGH-DeltaN .	Folic Acid	86-93	gamma-glutamyl hydrolase	Homo sapiens	33-36
35061292-1	2022	The human proton-coupled folate transporter (PCFT; SLC46A1) or hPCFT was identified in 2006 as the principal folate transporter involved in the intestinal absorption of dietary folates.	Folic Acid	109-115	solute carrier family 46 member 1	Homo sapiens	10-43
35061292-1	2022	The human proton-coupled folate transporter (PCFT; SLC46A1) or hPCFT was identified in 2006 as the principal folate transporter involved in the intestinal absorption of dietary folates.	Folic Acid	109-115	solute carrier family 46 member 1	Homo sapiens	45-49
35061292-1	2022	The human proton-coupled folate transporter (PCFT; SLC46A1) or hPCFT was identified in 2006 as the principal folate transporter involved in the intestinal absorption of dietary folates.	Folic Acid	109-115	solute carrier family 46 member 1	Homo sapiens	51-58
35061292-1	2022	The human proton-coupled folate transporter (PCFT; SLC46A1) or hPCFT was identified in 2006 as the principal folate transporter involved in the intestinal absorption of dietary folates.	Folic Acid	109-115	solute carrier family 46 member 1	Homo sapiens	63-68
35061292-1	2022	The human proton-coupled folate transporter (PCFT; SLC46A1) or hPCFT was identified in 2006 as the principal folate transporter involved in the intestinal absorption of dietary folates.	Folic Acid	177-184	solute carrier family 46 member 1	Homo sapiens	10-43
35061292-1	2022	The human proton-coupled folate transporter (PCFT; SLC46A1) or hPCFT was identified in 2006 as the principal folate transporter involved in the intestinal absorption of dietary folates.	Folic Acid	177-184	solute carrier family 46 member 1	Homo sapiens	45-49
35061292-1	2022	The human proton-coupled folate transporter (PCFT; SLC46A1) or hPCFT was identified in 2006 as the principal folate transporter involved in the intestinal absorption of dietary folates.	Folic Acid	177-184	solute carrier family 46 member 1	Homo sapiens	51-58
35061292-1	2022	The human proton-coupled folate transporter (PCFT; SLC46A1) or hPCFT was identified in 2006 as the principal folate transporter involved in the intestinal absorption of dietary folates.	Folic Acid	177-184	solute carrier family 46 member 1	Homo sapiens	63-68
2523018-2	1989	It has been suggested that CF provides a source of intracellular reduced folates which, in turn, enhances the inhibition of the cellular target thymidylate synthase (TS) by the FP metabolite 5-fluoro-2"-deoxyuridylate (FdUMP).	Folic Acid	73-80	thymidylate synthetase	Homo sapiens	144-164
2536692-6	1989	The apparent 160-kDa species specifically bound radiolabeled folates and were specifically immunoprecipitated by rabbit anti-40-kDa FBP antiserum.	Folic Acid	61-68	folate receptor beta	Homo sapiens	132-135
3247881-2	1988	An increase in the availability of reduced folates necessary for tight binding of FdUMP to thymidylate synthase (TS) contributes to the enhanced cytotoxicity of this drug combination.	Folic Acid	43-50	thymidylate synthetase	Homo sapiens	91-111
3409779-6	1988	Normal folate level frequencies of fra-X are restored by the time early S-phase cells (sub-phase SkI) reach metaphase.	Folic Acid	7-13	SKI proto-oncogene	Homo sapiens	97-100
7893997-3	1994	In this report, changes in the expression of three other genes in response to folic acid injury have been investigated: ornithine decarboxylase, epidermal growth factor (EGF), and sulfated glycoprotein-2 (SGP-2).	Folic Acid	78-88	epidermal growth factor	Mus musculus	145-168
7893997-3	1994	In this report, changes in the expression of three other genes in response to folic acid injury have been investigated: ornithine decarboxylase, epidermal growth factor (EGF), and sulfated glycoprotein-2 (SGP-2).	Folic Acid	78-88	epidermal growth factor	Mus musculus	170-173
7893997-3	1994	In this report, changes in the expression of three other genes in response to folic acid injury have been investigated: ornithine decarboxylase, epidermal growth factor (EGF), and sulfated glycoprotein-2 (SGP-2).	Folic Acid	78-88	clusterin	Mus musculus	180-203
7893997-3	1994	In this report, changes in the expression of three other genes in response to folic acid injury have been investigated: ornithine decarboxylase, epidermal growth factor (EGF), and sulfated glycoprotein-2 (SGP-2).	Folic Acid	78-88	clusterin	Mus musculus	205-210
7893997-6	1994	In contrast, folic acid caused a rapid increase in SGP-2 mRNA, which peaked several days after treatment, decreasing to normal levels over the 3-wk period.	Folic Acid	13-23	clusterin	Mus musculus	51-56
7893997-8	1994	In contrast, the changes in EGF and SGP-2 mRNA levels were blocked by cycloheximide, indicating that these responses required new protein synthesis during the first few hours after folic acid injury.	Folic Acid	181-191	epidermal growth factor	Mus musculus	28-31
7893997-8	1994	In contrast, the changes in EGF and SGP-2 mRNA levels were blocked by cycloheximide, indicating that these responses required new protein synthesis during the first few hours after folic acid injury.	Folic Acid	181-191	clusterin	Mus musculus	36-41
7874164-1	1994	Three folate-sensitive fragile sites, termed FRAXA, FRAXE and FRAXF, have been identified on the distal end of chromosome Xq.	Folic Acid	6-12	fragile site, folic acid type, rare, fra(X)(q28) E	Homo sapiens	52-57
7520695-1	1994	The aim of the present work was to further determine how the T-protein of the glycine-cleavage system and serine hydroxy-methyltransferase (SHMT), two folate-dependent enzymes from pea leaf mitochondria, interact through a common pool of tetrahydrofolate polyglutamates (H4PteGlun).	Folic Acid	151-157	serine hydroxymethyltransferase 1	Homo sapiens	106-138
7520695-1	1994	The aim of the present work was to further determine how the T-protein of the glycine-cleavage system and serine hydroxy-methyltransferase (SHMT), two folate-dependent enzymes from pea leaf mitochondria, interact through a common pool of tetrahydrofolate polyglutamates (H4PteGlun).	Folic Acid	151-157	serine hydroxymethyltransferase 1	Homo sapiens	140-144
8061055-1	1994	The folate receptor (FR), an essential component in the process of folate uptake in various cells, is known to exist in three isoforms, FR-alpha, FR-beta and FR-gamma, with differential tissue expression.	Folic Acid	4-10	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	136-144
8061055-1	1994	The folate receptor (FR), an essential component in the process of folate uptake in various cells, is known to exist in three isoforms, FR-alpha, FR-beta and FR-gamma, with differential tissue expression.	Folic Acid	4-10	folate receptor beta	Homo sapiens	146-153
8164259-11	1994	Further evaluation of the cytotoxicity of 1 and 2 in CCRF-CEM cells and its sublines, having defined mechanisms of methotrexate (MTX) resistance, demonstrated that the analogues utilize the reduced folate/MTX-transport system and primarily inhibit DHFR and that poly-gamma-glutamylation was crucial to their mechanism of action.	Folic Acid	198-204	dihydrofolate reductase	Homo sapiens	248-252
7511899-1	1994	Folate-binding protein (FBP) is responsible for the cellular transport of folate and methotrexate (MTX) in human KB (nasopharyngeal epidermoid carcinoma) cells.	Folic Acid	74-80	folate receptor alpha	Homo sapiens	0-22
7511899-1	1994	Folate-binding protein (FBP) is responsible for the cellular transport of folate and methotrexate (MTX) in human KB (nasopharyngeal epidermoid carcinoma) cells.	Folic Acid	74-80	folate receptor alpha	Homo sapiens	24-27
8145235-1	1994	Syntheses of several new inhibitors of thymidylate synthase (TS) structurally related to folic acid are described in which the pterin portion of the folate molecule is replaced by a benzo[f]quinazoline moiety, but which retain the natural methyleneamino link to the benzoylglutamate side chain.	Folic Acid	89-99	thymidylate synthetase	Homo sapiens	39-59
8145235-1	1994	Syntheses of several new inhibitors of thymidylate synthase (TS) structurally related to folic acid are described in which the pterin portion of the folate molecule is replaced by a benzo[f]quinazoline moiety, but which retain the natural methyleneamino link to the benzoylglutamate side chain.	Folic Acid	89-99	thymidylate synthetase	Homo sapiens	61-63
8145235-1	1994	Syntheses of several new inhibitors of thymidylate synthase (TS) structurally related to folic acid are described in which the pterin portion of the folate molecule is replaced by a benzo[f]quinazoline moiety, but which retain the natural methyleneamino link to the benzoylglutamate side chain.	Folic Acid	149-155	thymidylate synthetase	Homo sapiens	39-59
8145235-1	1994	Syntheses of several new inhibitors of thymidylate synthase (TS) structurally related to folic acid are described in which the pterin portion of the folate molecule is replaced by a benzo[f]quinazoline moiety, but which retain the natural methyleneamino link to the benzoylglutamate side chain.	Folic Acid	149-155	thymidylate synthetase	Homo sapiens	61-63
8145235-6	1994	The excellent combination of TS inhibitory activity, FPGS substrate activity, and affinity for the reduced folate transport system in the most potent of these derivatives, 3e, resulted in IC50 values of 0.2-0.8 nM against these tumor lines.	Folic Acid	107-113	thymidylate synthetase	Homo sapiens	29-31
8123474-0	1994	Inhibition of leukaemia cell proliferation by folic acid-polylysine-mediated introduction of c-myb antisense oligodeoxynucleotides into HL-60 cells.	Folic Acid	46-56	MYB proto-oncogene, transcription factor	Homo sapiens	93-98
8123474-1	1994	The inhibitory effect of c-myb antisense oligodeoxynucleotides (ODNs) conjugated to folic acid (FA) on HL-60 cell proliferation was examined.	Folic Acid	84-94	MYB proto-oncogene, transcription factor	Homo sapiens	25-30
8270640-1	1993	It has been demonstrated that proteins covalently conjugated to folic acid may be taken up by cells via endocytosis after binding to a folate binding protein (FBP) in the cell membrane.	Folic Acid	64-74	folate receptor alpha	Homo sapiens	135-157
8270640-1	1993	It has been demonstrated that proteins covalently conjugated to folic acid may be taken up by cells via endocytosis after binding to a folate binding protein (FBP) in the cell membrane.	Folic Acid	64-74	folate receptor alpha	Homo sapiens	159-162
8398636-7	1993	These schedules appear to be the most effective in the generation of the higher polyglutamates of 5,10-methylenetetrahydrofolate, the most efficient intracellular folate metabolite for ternary complex formation and TS inhibition.	Folic Acid	122-128	thymidylate synthetase	Homo sapiens	215-217
8361048-1	1993	Three methods for analyzing the products of polymerase chain reaction were applied to detect complex alterations of dihydrofolate reductase (DHFR) gene, in order to assess their value in detection of folate-resistance in leukemia cells.	Folic Acid	123-129	dihydrofolate reductase	Homo sapiens	141-145
3316519-3	1987	The original premise of LV rescue was that the provision of reduced folate to normal cells would circumvent the metabolic block produced by MTX and allow resumption of DNA synthesis, although the presumed therapeutic selectivity of leucovorin has not yet been adequately explained.	Folic Acid	68-74	metaxin 1	Homo sapiens	140-143
3110521-6	1987	The investigation of the folate metabolite pattern (determined by HPLC) showed that 5-CHO-THF and 5-methyl-tetrahydrofolic acid (5-CH3-THF) were the main metabolites in untreated mice.	Folic Acid	25-31	thin fur	Mus musculus	90-93
3110521-6	1987	The investigation of the folate metabolite pattern (determined by HPLC) showed that 5-CHO-THF and 5-methyl-tetrahydrofolic acid (5-CH3-THF) were the main metabolites in untreated mice.	Folic Acid	25-31	thin fur	Mus musculus	135-138
3110521-7	1987	After supplementation with 5-CHO-THF, only the concentrations of this folate vitamer were increased in the plasma from 0.3 microgram/ml (normal) to 0.6 or 1.9 micrograms/ml (after injection of 3 x 1 mg/kg or 3 X 4 mg/kg) and to 4.2 micrograms/ml (after infusion via osmotic minipumps).	Folic Acid	70-76	thin fur	Mus musculus	33-36
3499906-0	1987	[Interaction of muscle glycogen phosphorylase B with methotrexate, folic and folinic acids].	Folic Acid	67-72	LOW QUALITY PROTEIN: glycogen phosphorylase, brain form	Oryctolagus cuniculus	23-47
3499906-1	1987	The interaction of rabbit skeletal muscle glycogen phosphorylase b with methotrexate, folic and folinic acids has been studied.	Folic Acid	86-91	LOW QUALITY PROTEIN: glycogen phosphorylase, brain form	Oryctolagus cuniculus	42-66
3499906-5	1987	Methotrexate, folic and folinic acids are found to be inhibitors of the muscle glycogen phosphorylase b.	Folic Acid	14-19	LOW QUALITY PROTEIN: glycogen phosphorylase, brain form	Oryctolagus cuniculus	79-103
3565582-11	1987	This sequence of urinary clearance is in inverse order to the affinities of these three forms of folate for the kidney BBM FBP.	Folic Acid	97-103	folate receptor alpha	Homo sapiens	123-126
3565583-3	1987	Surface proximal convoluted tubules (PCT) in rats were microinfused in situ with [3H]folic acid to study the role of folate binding protein (FBP) in the kidney brush-border membrane for renal conservation and transport of folate [3H]folic acid absorption was linearly related to tubular length of PCT and occurred largely in this segment of the tubule.	Folic Acid	117-123	glycine N-methyltransferase	Rattus norvegicus	141-144
3565583-7	1987	It is proposed that the brush-border FBP functions as a receptor of infused folic acid and that following the binding of the ligand the folic acid/FBP complex undergoes a rapid change that results in the internalization of folic acid and regeneration of unsaturated binding sites at the membrane surface.	Folic Acid	76-86	glycine N-methyltransferase	Rattus norvegicus	37-40
3565583-7	1987	It is proposed that the brush-border FBP functions as a receptor of infused folic acid and that following the binding of the ligand the folic acid/FBP complex undergoes a rapid change that results in the internalization of folic acid and regeneration of unsaturated binding sites at the membrane surface.	Folic Acid	76-86	glycine N-methyltransferase	Rattus norvegicus	147-150
3565583-7	1987	It is proposed that the brush-border FBP functions as a receptor of infused folic acid and that following the binding of the ligand the folic acid/FBP complex undergoes a rapid change that results in the internalization of folic acid and regeneration of unsaturated binding sites at the membrane surface.	Folic Acid	136-146	glycine N-methyltransferase	Rattus norvegicus	37-40
3565583-7	1987	It is proposed that the brush-border FBP functions as a receptor of infused folic acid and that following the binding of the ligand the folic acid/FBP complex undergoes a rapid change that results in the internalization of folic acid and regeneration of unsaturated binding sites at the membrane surface.	Folic Acid	136-146	glycine N-methyltransferase	Rattus norvegicus	147-150
3565583-7	1987	It is proposed that the brush-border FBP functions as a receptor of infused folic acid and that following the binding of the ligand the folic acid/FBP complex undergoes a rapid change that results in the internalization of folic acid and regeneration of unsaturated binding sites at the membrane surface.	Folic Acid	136-146	glycine N-methyltransferase	Rattus norvegicus	37-40
3565583-7	1987	It is proposed that the brush-border FBP functions as a receptor of infused folic acid and that following the binding of the ligand the folic acid/FBP complex undergoes a rapid change that results in the internalization of folic acid and regeneration of unsaturated binding sites at the membrane surface.	Folic Acid	136-146	glycine N-methyltransferase	Rattus norvegicus	147-150
3470522-0	1987	Folate analogues as inhibitors of thymidylate synthase.	Folic Acid	0-6	thymidylate synthetase	Homo sapiens	34-54
3470522-5	1987	Comparison of the data for various folate analogues reveals a striking dependence of TS inhibitory potency upon the number of nitrogens in the folate pyrazine ring.	Folic Acid	35-41	thymidylate synthetase	Homo sapiens	85-87
2867507-2	1985	This compound reduced the number and size of the synaptically evoked population spikes recorded in the CA1 region in the presence of the convulsants, pentylenetetrazol, bicuculline or folate.	Folic Acid	184-190	carbonic anhydrase 1	Rattus norvegicus	103-106
3907060-4	1985	Altogether seven patients had low folate levels in both serum and CSF.	Folic Acid	34-40	colony stimulating factor 2	Homo sapiens	66-69
3907060-5	1985	After being treated in the hospital for one week, both serum and CSF folate levels increased in nine convalescent subjects.	Folic Acid	69-75	colony stimulating factor 2	Homo sapiens	65-68
3907060-6	1985	The CSF folate levels were statistically significantly higher than those of the acute malarial stage.	Folic Acid	8-14	colony stimulating factor 2	Homo sapiens	4-7
3907060-7	1985	These findings indicated that both serum and CSF folate levels were depressed in patients with cerebral malaria and increased after recovery.	Folic Acid	49-55	colony stimulating factor 2	Homo sapiens	45-48
3873989-0	1985	Folate analogues as substrates of mammalian folylpolyglutamate synthetase.	Folic Acid	0-6	folylpolyglutamate synthase	Homo sapiens	44-73
6716181-5	1984	The similar effect of FBP was also observed when the biliary excretion of 3H-labeled folate compounds was investigated in situ.	Folic Acid	85-91	glycine N-methyltransferase	Rattus norvegicus	22-25
6716181-6	1984	Furthermore, the incorporation of [3H]PteGlu into folate-requiring intestinal microorganisms was considerably reduced when it was bound to FBP.	Folic Acid	50-56	glycine N-methyltransferase	Rattus norvegicus	139-142
6716181-7	1984	These results suggest that milk FBP has some nutritional effects on the bioavailability of folate in vivo.	Folic Acid	91-97	glycine N-methyltransferase	Rattus norvegicus	32-35
6324026-1	1984	The actions of the neurotoxic amino acids folate and kainate have been compared on ortho-and antidromic responses evoked in CA1, CA3 and the dentate gyrus of slices of rat hippocampus maintained in vitro.	Folic Acid	42-48	carbonic anhydrase 1	Rattus norvegicus	124-127
6661412-3	1983	Comparison of certain folate-requiring enzymes from crude extracts of the parent and resistant cells showed a 240-fold elevation of dihydrofolate reductase activity in the resistant cells with no significant increase in the levels of the other enzymes.	Folic Acid	22-28	dihydrofolate reductase	Homo sapiens	132-155
6193143-2	1983	Methotrexate (MTX-Glu1) exerts its antitumor effects through its potent inhibition of dihydrofolate reductase (DHFR), the enzyme responsible for maintaining the cellular pool of reduced folates.	Folic Acid	186-193	dihydrofolate reductase	Homo sapiens	86-109
6193143-2	1983	Methotrexate (MTX-Glu1) exerts its antitumor effects through its potent inhibition of dihydrofolate reductase (DHFR), the enzyme responsible for maintaining the cellular pool of reduced folates.	Folic Acid	186-193	dihydrofolate reductase	Homo sapiens	111-115
6947034-2	1981	This binder is similar to a previously purified protein from CML cells (FBP-L) in its molecular weight and affinity for folate analogues.	Folic Acid	120-126	folate receptor beta	Homo sapiens	72-75
7011378-1	1981	Reduced nicotinamide adenine dinucleotide phosphate (NADPH), folate, dihydrofolate, and the inhibitors trimethoprim and methotrexate bind rapidly and reversibly to both dihydrofolate reductase isoenzymes isolated from Escherichia coli RT500.	Folic Acid	61-67	Dihydrofolate reductase	Escherichia coli	169-192
6165215-0	1981	Effect of a folate-binding protein on the plasma transport and tissue distribution of folic acid.	Folic Acid	86-96	folate receptor alpha	Homo sapiens	12-34
6165215-1	1981	Folic acid (3H-pteroylglutamic acid or 75Se-selenofolate) administered free or bound to folate-binding protein (FABP) was rapidly cleared from the plasma but the plasma survival when bound to FABP was longer than unbound during the initial 5 min.	Folic Acid	0-10	folate receptor alpha	Homo sapiens	88-110
6165215-1	1981	Folic acid (3H-pteroylglutamic acid or 75Se-selenofolate) administered free or bound to folate-binding protein (FABP) was rapidly cleared from the plasma but the plasma survival when bound to FABP was longer than unbound during the initial 5 min.	Folic Acid	0-10	folate receptor alpha	Homo sapiens	112-116
6165215-1	1981	Folic acid (3H-pteroylglutamic acid or 75Se-selenofolate) administered free or bound to folate-binding protein (FABP) was rapidly cleared from the plasma but the plasma survival when bound to FABP was longer than unbound during the initial 5 min.	Folic Acid	0-10	folate receptor alpha	Homo sapiens	192-196
6165215-2	1981	75Se-folate bound to FABP is more rapidly taken up by the liver than when administered as free 75-Se-folate.	Folic Acid	5-11	folate receptor alpha	Homo sapiens	21-25
6165215-6	1981	The total biliary secretion of 75Se-folate over 240 min was 63% when administered bound to FABP and 33% when administered as free 75Se-folate.	Folic Acid	36-42	folate receptor alpha	Homo sapiens	91-95
6165215-8	1981	This data suggests that FABP may play an important role in the enterohepatic circulation of folates by directing nonmethylated folates to the liver.	Folic Acid	92-99	folate receptor alpha	Homo sapiens	24-28
6165215-8	1981	This data suggests that FABP may play an important role in the enterohepatic circulation of folates by directing nonmethylated folates to the liver.	Folic Acid	127-134	folate receptor alpha	Homo sapiens	24-28
6794338-2	1981	The intestinal uptake of D-glucose and L-alanine and the brush border sucrase, lactase and alkaline phosphatase activities were considerably depressed in folate deficient animals compared to the control group.	Folic Acid	154-160	lactase	Rattus norvegicus	79-86
6255104-6	1980	Folate therapy significantly reversed abnormalities in motor and sensory nerve distal latencies; the effect was greater with 5-formyltetrahydrofolate, apparently because this produced higher CSF folate concentrations than folic acid.	Folic Acid	0-6	colony stimulating factor 2	Homo sapiens	191-194
6255104-6	1980	Folate therapy significantly reversed abnormalities in motor and sensory nerve distal latencies; the effect was greater with 5-formyltetrahydrofolate, apparently because this produced higher CSF folate concentrations than folic acid.	Folic Acid	143-149	colony stimulating factor 2	Homo sapiens	191-194
22555-3	1978	To further explore the mechanism of sulfasalazine action, the interaction of the drug with the folate recognition site was tested with three enzymes: dihydrofolate reductase, methylenetetrahydrofolate reductase, and serine transhydroxymethylase, each catalyzing a reaction involving a different folate derivative.	Folic Acid	95-101	methylenetetrahydrofolate reductase	Gallus gallus	175-210
4212249-0	1974	Polyglutamyl derivatives of folate as substrates and inhibitors of thymidylate synthetase.	Folic Acid	28-34	thymidylate synthetase	Homo sapiens	67-89
33719573-10	2021	Finally, we applied dMRI to investigate kidney pathology in a mouse model of folic-acid induced acute kidney injury (AKI).	Folic Acid	77-87	mrityu	Drosophila melanogaster	20-24
33904374-1	2021	Among the various known targets for the treatment of Leishmaniasis, dihydrofolate reductase (DHFR) is an essential target which plays an important role in the folate metabolic pathway.	Folic Acid	75-81	dihydrofolate reductase	Homo sapiens	93-97
33782411-0	2021	The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation.	Folic Acid	4-10	CD274 molecule	Homo sapiens	69-74
33782411-6	2021	Meanwhile, MTHFD2 drives the folate cycle to sustain sufficient uridine-related metabolites including UDP-GlcNAc, which promotes the global O-GlcNAcylation of proteins including cMYC, resulting in increased cMYC stability and PD-L1 transcription.	Folic Acid	29-35	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	178-182
33782411-6	2021	Meanwhile, MTHFD2 drives the folate cycle to sustain sufficient uridine-related metabolites including UDP-GlcNAc, which promotes the global O-GlcNAcylation of proteins including cMYC, resulting in increased cMYC stability and PD-L1 transcription.	Folic Acid	29-35	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	207-211
33782411-6	2021	Meanwhile, MTHFD2 drives the folate cycle to sustain sufficient uridine-related metabolites including UDP-GlcNAc, which promotes the global O-GlcNAcylation of proteins including cMYC, resulting in increased cMYC stability and PD-L1 transcription.	Folic Acid	29-35	CD274 molecule	Homo sapiens	226-231
8451757-5	1993	Finally, the expression of c-myc and c-fos is induced after unilateral nephrectomy during compensatory renal growth in the remaining kidney and also during regenerative cell proliferation after in vivo application of the strong nephrotoxins folic acid and mercury chloride.	Folic Acid	241-251	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	27-32
8461049-0	1993	Effect of folate diastereoisomers on the binding of 5-fluoro-2"-deoxyuridine-5"-monophosphate to thymidylate synthase.	Folic Acid	10-16	thymidylate synthetase	Homo sapiens	97-117
8461049-1	1993	A series of natural and unnatural stereoisomers of reduced folate coenzymes have been studied for their capacity to facilitate binding of 5-fluoro-2"-dUMP (FdUMP) to bacterial thymidylate synthase (TS).	Folic Acid	59-65	thymidylate synthetase	Homo sapiens	176-196
8461049-1	1993	A series of natural and unnatural stereoisomers of reduced folate coenzymes have been studied for their capacity to facilitate binding of 5-fluoro-2"-dUMP (FdUMP) to bacterial thymidylate synthase (TS).	Folic Acid	59-65	thymidylate synthetase	Homo sapiens	198-200
8461049-4	1993	These results suggest that folates, which are not a natural cosubstrate for TS, have an additional role in facilitating FdUMP binding to TS.	Folic Acid	27-34	thymidylate synthetase	Homo sapiens	137-139
1619631-8	1992	A further two families had consistent expression of a different folate sensitive fragile site, FRAXE, close to FRAXA but not associated with fragile X syndrome and not detectable with the pfxa3 probe.	Folic Acid	64-70	fragile site, folic acid type, rare, fra(X)(q28) E	Homo sapiens	95-100
1602376-10	1992	In the responsive murine fibroblasts and the glioma cells, the homocysteine export rate varied inversely to the changes in methionine synthase activity induced by nitrous oxide exposure at different concentrations of folate in the medium.	Folic Acid	217-223	5-methyltetrahydrofolate-homocysteine methyltransferase	Mus musculus	123-142
1314649-0	1992	Effect of enzyme and ligand protonation on the binding of folates to recombinant human dihydrofolate reductase: implications for the evolution of eukaryotic enzyme efficiency.	Folic Acid	58-65	dihydrofolate reductase	Homo sapiens	87-110
1314649-4	1992	koff for dissociation of folate, dihydrofolate (H2folate), and H4folate from their binary complexes with hDHFR is similarly pH dependent.	Folic Acid	25-31	dihydrofolate reductase	Homo sapiens	105-110
1572659-2	1992	The fusion point is localized in chromosomal band 2q13, which also contains the rare, folate-sensitive fragile site FRA2B.	Folic Acid	86-92	fragile site, folic acid type, rare, fra(2)(q13)	Homo sapiens	116-121
1548676-1	1992	Antifolate inhibitors of thymidylate synthase (TS) have primarily been based on the structure of folic acid.	Folic Acid	97-107	thymidylate synthetase	Homo sapiens	25-45
1548676-1	1992	Antifolate inhibitors of thymidylate synthase (TS) have primarily been based on the structure of folic acid.	Folic Acid	97-107	thymidylate synthetase	Homo sapiens	47-49
1737372-0	1992	Human lymphoblastoid cells with acquired resistance to C2-desamino-C2-methyl-N10-propargyl-5,8-dideazafolic acid: a novel folate-based thymidylate synthase inhibitor.	Folic Acid	122-128	thymidylate synthetase	Homo sapiens	135-155
1737372-6	1992	The resistant cell line, W1-L2:C1, was cross-resistant to other folate-based TS inhibitors but was as sensitive as the parent cell line, W1-L2, to 5-fluorodeoxyuridine.	Folic Acid	64-70	thymidylate synthetase	Homo sapiens	77-79
1741766-5	1991	The measurement of folylpolyglutamate synthetase (FPGS) substrate activity demonstrated a Km of 40 microM for ICI 198583 and a Vmax/Km (relative to folic acid) of 3.5.	Folic Acid	148-158	folylpolyglutamyl synthetase	Mus musculus	19-48
1741766-5	1991	The measurement of folylpolyglutamate synthetase (FPGS) substrate activity demonstrated a Km of 40 microM for ICI 198583 and a Vmax/Km (relative to folic acid) of 3.5.	Folic Acid	148-158	folylpolyglutamyl synthetase	Mus musculus	50-54
1712425-1	1991	HPRT mutant clones of V79 Chinese hamster cells, isolated after 6-thioguanine (6TG) selection, normally exhibit sensitivity to growth in medium containing the folic acid inhibitor aminopterin or the glutamine analogue L-azaserine (e.g., HAT or HAsT medium).	Folic Acid	159-169	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	0-4
1904273-1	1991	A fluorescein derivative of the lysine analogue of folic acid, N alpha-pteroyl-N epilson-(4"-fluoresceinthiocarbamoyl)-L-lysine (PLF), was synthesized as a probe for dihydrofolate reductase (DHFR) and a membrane folate binding protein (m-FBP).	Folic Acid	51-61	dihydrofolate reductase	Homo sapiens	166-189
1904273-1	1991	A fluorescein derivative of the lysine analogue of folic acid, N alpha-pteroyl-N epilson-(4"-fluoresceinthiocarbamoyl)-L-lysine (PLF), was synthesized as a probe for dihydrofolate reductase (DHFR) and a membrane folate binding protein (m-FBP).	Folic Acid	51-61	dihydrofolate reductase	Homo sapiens	191-195
1904273-1	1991	A fluorescein derivative of the lysine analogue of folic acid, N alpha-pteroyl-N epilson-(4"-fluoresceinthiocarbamoyl)-L-lysine (PLF), was synthesized as a probe for dihydrofolate reductase (DHFR) and a membrane folate binding protein (m-FBP).	Folic Acid	51-61	folate receptor beta	Homo sapiens	238-241
1904273-6	1991	The dissociation constant for the fluorescein derivative with respect to human DHFR is 115 nM as compared to 111 nM for folic acid.	Folic Acid	120-130	dihydrofolate reductase	Homo sapiens	79-83
1904273-7	1991	The Ki value for the competitive inhibition of human DHFR by the fluorescent analogue of folic acid is 2.0 microM compared to 0.48 microM for folic acid.	Folic Acid	89-99	dihydrofolate reductase	Homo sapiens	53-57
1904273-7	1991	The Ki value for the competitive inhibition of human DHFR by the fluorescent analogue of folic acid is 2.0 microM compared to 0.48 microM for folic acid.	Folic Acid	142-152	dihydrofolate reductase	Homo sapiens	53-57
2058704-4	1991	Induction of TIS 1, TIS 8, and TIS 11 mRNA levels following folic acid administration peaked at 2 to 4 h and persisted up to 6 to 12 h after mitogenic stimulation.	Folic Acid	60-70	nuclear receptor subfamily 4, group A, member 1	Mus musculus	13-18
2058704-4	1991	Induction of TIS 1, TIS 8, and TIS 11 mRNA levels following folic acid administration peaked at 2 to 4 h and persisted up to 6 to 12 h after mitogenic stimulation.	Folic Acid	60-70	early growth response 1	Mus musculus	20-25
1996614-6	1991	These data support a mechanism of receptor-mediated endocytosis for the process of FBP-mediated folate transport in the kidney.	Folic Acid	96-102	glycine N-methyltransferase	Rattus norvegicus	83-86
1705463-2	1991	Alterations in CSF amine metabolite levels were related primarily to PHT intoxication, and low CSF folate and thiamine levels, but not to length of treatment or CNS atrophy.	Folic Acid	99-105	colony stimulating factor 2	Homo sapiens	15-18
1705463-2	1991	Alterations in CSF amine metabolite levels were related primarily to PHT intoxication, and low CSF folate and thiamine levels, but not to length of treatment or CNS atrophy.	Folic Acid	99-105	colony stimulating factor 2	Homo sapiens	95-98
1705463-4	1991	Low folate levels were associated with decreased CSF 5HIAA and homovanillic acid, while low thiamine levels were associated with decreased CSF 5HIAA and 3-methyoxy-4-hydroxyphenylethylene glycol.	Folic Acid	4-10	colony stimulating factor 2	Homo sapiens	49-52
1961697-1	1991	Escherichia coli dihydrofolate reductase (DHFR) carries a net charge of -10 electrons yet it binds ligands with net charges of -4 (NADPH) and -2 (folate or dihydrofolate).	Folic Acid	24-30	Dihydrofolate reductase	Escherichia coli	42-46
1961697-7	1991	The positive electrostatic potential at the entrance of the ligand binding site in E. coli DHFR is shown to be a direct consequence of the presence of three positively charged residues at positions 32, 52, and 57--residues which have also been shown recently to contribute significantly to electronic polarization of the ligand folate.	Folic Acid	328-334	Dihydrofolate reductase	Escherichia coli	91-95
2006139-1	1991	The migration of electron density of a substrate (folate) on binding to an enzyme (dihydrofolate reductase) is studied by a quantum-mechanical method originally developed in solid state physics.	Folic Acid	50-56	dihydrofolate reductase	Homo sapiens	83-106
2233711-0	1990	Molecular genetic analysis of Saccharomyces cerevisiae C1-tetrahydrofolate synthase mutants reveals a noncatalytic function of the ADE3 gene product and an additional folate-dependent enzyme.	Folic Acid	68-74	trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase ADE3	Saccharomyces cerevisiae S288C	131-135
2190985-0	1990	The presence and distribution of reduced folates in Escherichia coli dihydrofolate reductase mutants.	Folic Acid	41-48	Dihydrofolate reductase	Escherichia coli	69-92
2341911-5	1990	On the basis of PPH activity, volume of the postprandial secretion and pH profile of enzyme activity, it is suggested that pancreatic PPH may act in vivo in folate digestion and absorption to initiate the deconjugation of dietary PteGlun prior to the action of jejunal brush border PPH.	Folic Acid	157-163	enolase 1	Homo sapiens	134-137
2341911-5	1990	On the basis of PPH activity, volume of the postprandial secretion and pH profile of enzyme activity, it is suggested that pancreatic PPH may act in vivo in folate digestion and absorption to initiate the deconjugation of dietary PteGlun prior to the action of jejunal brush border PPH.	Folic Acid	157-163	enolase 1	Homo sapiens	134-137
2178951-10	1990	Interestingly, pyrimethamine-resistant strains of P. falciparum have a common point mutation in the DHFR coding sequence which causes decreased binding of the folate analog.	Folic Acid	159-165	dihydrofolate reductase	Homo sapiens	100-104
2180768-7	1990	Anti-folates commonly used to treat microbial infections are poor inhibitors of L. major DHFR.	Folic Acid	5-12	dihydrofolate reductase	Homo sapiens	89-93
2206778-8	1990	These results derived from an in vivo tumor model provide further evidence for a role of FPGS as a determinant of cytotoxicity and acquired resistance to classical folate analogs.	Folic Acid	164-170	folylpolyglutamyl synthetase	Mus musculus	89-93
2369839-2	1990	First, five cosmids situated along the short arm of chromosome 16 were used to map the breakpoint of the inversion distal to the rare folate-sensitive fragile site FRA16A.	Folic Acid	134-140	fragile site, folic acid type, rare, fra(16)(p13.11)	Homo sapiens	164-170
2195551-3	1990	Reduced folates (LV and 5-methyltetrahydrofolate) at concentrations greater than or equal to 1 microM can, by raising the intracellular levels of 5,10-methylenetetrahydrofolate, increase and prolong the inhibition of the target enzyme, thymidylate synthase, with formation of a stable ternary complex formed by the enzyme, the folate coenzyme and the fluoropyrimidine inhibitor (5-fluorodeoxyuridylate).	Folic Acid	8-14	thymidylate synthetase	Homo sapiens	236-256
34823779-2	2022	In this study, redox-sensitive folate-appended-polyethylenimine-beta-cyclodextrin (roFPC) host-guest supramolecular nanoparticles (HGSNPs) were developed as a targeted co-delivery system of doxorubicin (Dox) and Human telomerase reverse transcriptase-small interfering RNA) hTERT siRNA) for potential cancer therapy.	Folic Acid	31-37	telomerase reverse transcriptase	Homo sapiens	274-279
34953021-5	2022	Meanwhile, the results of animal model and spermatocyte line (GC-2) also found that folic acid deficiency can increase the methylation level in Rad54 promoter region, increased sperm DFI in mice, increased the expression of gamma-H2AX, that is, DNA injury marker protein, and increased sensitivity of GC-2 to external damage and stimulation.	Folic Acid	84-94	RAD54 like (S. cerevisiae)	Mus musculus	144-149
34953021-6	2022	The study indicates that the expression of Rad54 is downregulated by folic acid deficiency via DNA methylation.	Folic Acid	69-79	RAD54 like (S. cerevisiae)	Mus musculus	43-48
34953855-8	2022	We identified human dihydrofolate reductase (DHFR) as a target of pyrimethamine and demonstrated that the STAT3-inhibitory effects of pyrimethamine are the result of a deficiency in reduced folate downstream of DHFR inhibition, implicating folate metabolism in the regulation of STAT3 transcriptional activity.	Folic Acid	190-196	dihydrofolate reductase	Homo sapiens	20-43
34953855-8	2022	We identified human dihydrofolate reductase (DHFR) as a target of pyrimethamine and demonstrated that the STAT3-inhibitory effects of pyrimethamine are the result of a deficiency in reduced folate downstream of DHFR inhibition, implicating folate metabolism in the regulation of STAT3 transcriptional activity.	Folic Acid	190-196	dihydrofolate reductase	Homo sapiens	45-49
34953855-8	2022	We identified human dihydrofolate reductase (DHFR) as a target of pyrimethamine and demonstrated that the STAT3-inhibitory effects of pyrimethamine are the result of a deficiency in reduced folate downstream of DHFR inhibition, implicating folate metabolism in the regulation of STAT3 transcriptional activity.	Folic Acid	190-196	dihydrofolate reductase	Homo sapiens	211-215
34953855-8	2022	We identified human dihydrofolate reductase (DHFR) as a target of pyrimethamine and demonstrated that the STAT3-inhibitory effects of pyrimethamine are the result of a deficiency in reduced folate downstream of DHFR inhibition, implicating folate metabolism in the regulation of STAT3 transcriptional activity.	Folic Acid	240-246	dihydrofolate reductase	Homo sapiens	20-43
34953855-8	2022	We identified human dihydrofolate reductase (DHFR) as a target of pyrimethamine and demonstrated that the STAT3-inhibitory effects of pyrimethamine are the result of a deficiency in reduced folate downstream of DHFR inhibition, implicating folate metabolism in the regulation of STAT3 transcriptional activity.	Folic Acid	240-246	dihydrofolate reductase	Homo sapiens	45-49
34959947-6	2021	Furthermore, biological pathways leading to rumination appeared to differ according to folate intake: purinergic signaling and circadian regulator gene ARNTL emerged in the whole sample, blastocyst development, DNA replication, and C-C chemokines in the suboptimal folate group, and prostaglandin response and K+ channel subunit gene KCNH3 in the optimal folate group.	Folic Acid	87-93	potassium voltage-gated channel subfamily H member 3	Homo sapiens	334-339
34710812-1	2021	Human dihydrofolate reductase (DHFR) is a conserved enzyme that is central to folate metabolism and is widely targeted in pathogenic diseases as well as cancers.	Folic Acid	78-84	dihydrofolate reductase	Homo sapiens	6-29
34710812-1	2021	Human dihydrofolate reductase (DHFR) is a conserved enzyme that is central to folate metabolism and is widely targeted in pathogenic diseases as well as cancers.	Folic Acid	78-84	dihydrofolate reductase	Homo sapiens	31-35
34358645-2	2021	We have demonstrated that Ceramide Synthase 6 (CerS6) and C16:0-ceramide mediate response to folate stress in cultured cells.	Folic Acid	93-99	ceramide synthase 6	Mus musculus	26-45
34358645-2	2021	We have demonstrated that Ceramide Synthase 6 (CerS6) and C16:0-ceramide mediate response to folate stress in cultured cells.	Folic Acid	93-99	ceramide synthase 6	Mus musculus	47-52
34718458-4	2021	RESULTS: The detection limits of DVUDLLME-HPLC were 0.21 ng mL-1, 0.18 ng mL-1 and 55 pgmL-1 for vitamin B9, 5-MeTHF and vitamin B12, respectively.	Folic Acid	97-107	L1 cell adhesion molecule	Mus musculus	74-78
34687208-0	2022	Maternal intake of folate during pregnancy and risk of cerebral palsy in the MOBAND-CP cohort.	Folic Acid	19-25	ceruloplasmin	Homo sapiens	84-86
34687208-2	2022	OBJECTIVE(S): To investigate whether higher intakes of periconceptional or midpregnancy folate as recommended were associated with a reduced risk of offspring cerebral palsy (CP).	Folic Acid	88-94	ceruloplasmin	Homo sapiens	175-177
34687208-11	2022	Strong inverse associations were observed with low gross motor function impairment (aOR 0.49; 0.29, 0.83), while for unilateral CP the aOR was 0.63 (0.34, 1.22) for intakes of >= 500 compared to <= 199 dietary folate equivalents/day during midpregnancy.	Folic Acid	210-216	ceruloplasmin	Homo sapiens	128-130
34687208-12	2022	CONCLUSIONS: Our findings suggested that folate intakes in GWs 9 to 12 and midpregnancy were associated with a lower risk of CP, while no association was observed for periconceptional supplementation.	Folic Acid	41-47	ceruloplasmin	Homo sapiens	125-127
34104947-0	2021	A high level of KLF12 causes folic acid-resistant neural tube defects by activating the Shh signalling pathway in mice.	Folic Acid	29-39	sonic hedgehog	Mus musculus	88-91
34352110-6	2021	Two of the interactions, one with the folate biosynthetic enzyme DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE 1 (AtDHFR-TS1) and another with nitrogen metabolism-associated glutamine synthetase 1;4 (AtGLN1;4), were further characterized.	Folic Acid	38-44	thymidylate synthase 1	Arabidopsis thaliana	89-111
34500740-0	2021	Conjugated beta-Cyclodextrin Enhances the Affinity of Folic Acid towards FRalpha: Molecular Dynamics Study.	Folic Acid	54-64	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	73-80
34500740-2	2021	The binding affinity of folic acid (FA) to the FRalpha active site provides a basis for recognition of FRalpha.	Folic Acid	24-34	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	47-54
34500740-2	2021	The binding affinity of folic acid (FA) to the FRalpha active site provides a basis for recognition of FRalpha.	Folic Acid	24-34	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	103-110
34185411-1	2021	BACKGROUND: The main function of folate receptor alpha (FOLRalpha) has been considered to mediate intracellular folate uptake and induce tumor cell proliferation.	Folic Acid	112-118	folate receptor alpha	Homo sapiens	33-54
35303537-3	2022	Three different systems control folate uptake in the human body; folate receptors function to capture and internalise extracellular folates via endocytosis, whereas two major facilitator superfamily transporters, the reduced folate carrier (RFC; SLC19A1) and proton-coupled folate transporter (PCFT; SLC46A1) control the transport of folates across cellular membranes.	Folic Acid	32-38	solute carrier family 46 member 1	Homo sapiens	294-298
35303537-3	2022	Three different systems control folate uptake in the human body; folate receptors function to capture and internalise extracellular folates via endocytosis, whereas two major facilitator superfamily transporters, the reduced folate carrier (RFC; SLC19A1) and proton-coupled folate transporter (PCFT; SLC46A1) control the transport of folates across cellular membranes.	Folic Acid	32-38	solute carrier family 46 member 1	Homo sapiens	300-307
35303537-3	2022	Three different systems control folate uptake in the human body; folate receptors function to capture and internalise extracellular folates via endocytosis, whereas two major facilitator superfamily transporters, the reduced folate carrier (RFC; SLC19A1) and proton-coupled folate transporter (PCFT; SLC46A1) control the transport of folates across cellular membranes.	Folic Acid	132-139	solute carrier family 46 member 1	Homo sapiens	294-298
35303537-3	2022	Three different systems control folate uptake in the human body; folate receptors function to capture and internalise extracellular folates via endocytosis, whereas two major facilitator superfamily transporters, the reduced folate carrier (RFC; SLC19A1) and proton-coupled folate transporter (PCFT; SLC46A1) control the transport of folates across cellular membranes.	Folic Acid	132-139	solute carrier family 46 member 1	Homo sapiens	300-307
35303537-3	2022	Three different systems control folate uptake in the human body; folate receptors function to capture and internalise extracellular folates via endocytosis, whereas two major facilitator superfamily transporters, the reduced folate carrier (RFC; SLC19A1) and proton-coupled folate transporter (PCFT; SLC46A1) control the transport of folates across cellular membranes.	Folic Acid	225-231	solute carrier family 46 member 1	Homo sapiens	294-298
35303537-3	2022	Three different systems control folate uptake in the human body; folate receptors function to capture and internalise extracellular folates via endocytosis, whereas two major facilitator superfamily transporters, the reduced folate carrier (RFC; SLC19A1) and proton-coupled folate transporter (PCFT; SLC46A1) control the transport of folates across cellular membranes.	Folic Acid	225-231	solute carrier family 46 member 1	Homo sapiens	300-307
35337892-5	2022	Gdf15-deficient mice developed more severe toxic acute kidney injury (folic acid or cisplatin) while GDF15 overexpression or GDF15 administration were protective.	Folic Acid	70-80	growth differentiation factor 15	Mus musculus	0-5
35616003-14	2022	H19 was enriched in GO:0006555~methionine metabolic process, and GO:0046655~folic acid metabolic process.	Folic Acid	76-86	H19 imprinted maternally expressed transcript	Homo sapiens	0-3
35316734-9	2022	When the concentration of folic acid was tested, 20 muM and 500 muM presented a higher level of insulin-like growth factor (IGF2) DNA methylation pattern compared to control, suggesting that in vitro conditions alter DNA methylation pattern in that region and folic acid reestablishes the pattern.	Folic Acid	26-36	insulin	Bos taurus	96-103
35316734-9	2022	When the concentration of folic acid was tested, 20 muM and 500 muM presented a higher level of insulin-like growth factor (IGF2) DNA methylation pattern compared to control, suggesting that in vitro conditions alter DNA methylation pattern in that region and folic acid reestablishes the pattern.	Folic Acid	260-270	insulin	Bos taurus	96-103
35578613-12	2022	Folic acid supplementation was also observed to significantly decrease global methylation in placental trophoblasts related to decreasing expression of DNMT1 and DNMT3A.	Folic Acid	0-10	DNA methyltransferase 3 alpha	Homo sapiens	162-168
35548560-0	2022	Folate Deficiency Increased Lipid Accumulation and Leptin Production of Adipocytes.	Folic Acid	0-6	leptin	Mus musculus	51-57
35548560-4	2022	The aim of this study was to investigate the effects of dietary folate on lipid accumulation and leptin production using both in vivo and in vitro studies.	Folic Acid	64-70	leptin	Mus musculus	97-103
35548560-10	2022	Increased intracellular TG, leptin, monocyte chemotactic protein (MCP)-1 and interleukin (IL)-6 levels, and the expression of Hif1alpha and lipogenesis-related genes Cebpalpha, Cebpbeta, Acc1, Fasn, and Fabp4 were also detected in folate-deficient 3T3-L1 adipocytes.	Folic Acid	231-237	hypoxia inducible factor 1, alpha subunit	Mus musculus	126-135
35548560-11	2022	Our results suggested that folate deficiency increased lipid accumulation and leptin production of adipocytes, and thus, inadequate folate status might be one of the risk factors for adiposity.	Folic Acid	27-33	leptin	Mus musculus	78-84
35548560-11	2022	Our results suggested that folate deficiency increased lipid accumulation and leptin production of adipocytes, and thus, inadequate folate status might be one of the risk factors for adiposity.	Folic Acid	132-138	leptin	Mus musculus	78-84
35370749-7	2022	In LPS-induced ALI mice, FOL administration showed inhibition of IL-1beta, IL-6, and TNF-alpha in Bronchoalveolar lavage fluid (BALF) and decreased protein expression levels of PI3K, AKT, NF-kappaB p50, and NF-kappaB p65, and elevated protein expression levels of Bax and cleaved-caspase-3 significantly.	Folic Acid	25-28	interleukin 1 alpha	Mus musculus	65-73
35253073-3	2022	The enzymes Dihydrofolate reductase, thymidylate synthase, and Serine hydroxy methyltransferase play an essential role in the folate pathway.	Folic Acid	126-132	dihydrofolate reductase	Homo sapiens	12-35
35253073-3	2022	The enzymes Dihydrofolate reductase, thymidylate synthase, and Serine hydroxy methyltransferase play an essential role in the folate pathway.	Folic Acid	126-132	thymidylate synthetase	Homo sapiens	37-57
35126709-8	2022	Western blotting demonstrated that the expression levels of ERbeta and the phosphorylation levels of PI3K and AKT were decreased, whilst the expression levels of cleaved caspase-3 were increased, in the cerebral cortex of female mice that received folate-deficient diet.	Folic Acid	248-254	estrogen receptor 1 (alpha)	Mus musculus	60-66
35065186-7	2022	Furthermore, neurofunctional and neuromorphological abnormalities in the DG of low folate diet-fed mice, such as decreases in stress-induced expression of c-Fos (a neuronal activity marker), dendritic complexity and the number of mature spines, were improved by SAM supplementation.	Folic Acid	83-89	FBJ osteosarcoma oncogene	Mus musculus	155-160
35227297-9	2022	CONCLUSION: Folic acid plays a protective role against atherosclerosis through the regulation of DNA methylation, ARID5B expression, and monocyte subsets.	Folic Acid	12-22	AT-rich interaction domain 5B	Homo sapiens	114-120
35185910-3	2022	Over the past decade, selective expression of folate receptor beta (FRbeta), a glycosylphosphatidylinositol-anchored plasma membrane protein, on myeloid cells has emerged as an attractive target for macrophage imaging by exploiting the high binding affinity of folate-based PET tracers.	Folic Acid	261-267	folate receptor beta	Homo sapiens	46-66
35185910-3	2022	Over the past decade, selective expression of folate receptor beta (FRbeta), a glycosylphosphatidylinositol-anchored plasma membrane protein, on myeloid cells has emerged as an attractive target for macrophage imaging by exploiting the high binding affinity of folate-based PET tracers.	Folic Acid	261-267	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	68-74
35545363-3	2022	The purpose of this study is to investigate the association between periconceptional folic acid supplement, the genetic polymorphisms of maternal folic acid receptor 1 gene (FOLR1) and folic acid receptor 2 gene (FOLR2) and the impact of their interaction on the risk of CHD in offspring, and to provide epidemiological evidence for individualized folic acid dosing in hygienic counseling.	Folic Acid	85-95	folate receptor alpha	Homo sapiens	174-179
35545363-3	2022	The purpose of this study is to investigate the association between periconceptional folic acid supplement, the genetic polymorphisms of maternal folic acid receptor 1 gene (FOLR1) and folic acid receptor 2 gene (FOLR2) and the impact of their interaction on the risk of CHD in offspring, and to provide epidemiological evidence for individualized folic acid dosing in hygienic counseling.	Folic Acid	85-95	folate receptor beta	Homo sapiens	213-218
35545363-3	2022	The purpose of this study is to investigate the association between periconceptional folic acid supplement, the genetic polymorphisms of maternal folic acid receptor 1 gene (FOLR1) and folic acid receptor 2 gene (FOLR2) and the impact of their interaction on the risk of CHD in offspring, and to provide epidemiological evidence for individualized folic acid dosing in hygienic counseling.	Folic Acid	146-156	folate receptor alpha	Homo sapiens	174-179
35545363-3	2022	The purpose of this study is to investigate the association between periconceptional folic acid supplement, the genetic polymorphisms of maternal folic acid receptor 1 gene (FOLR1) and folic acid receptor 2 gene (FOLR2) and the impact of their interaction on the risk of CHD in offspring, and to provide epidemiological evidence for individualized folic acid dosing in hygienic counseling.	Folic Acid	185-195	folate receptor beta	Homo sapiens	213-218
35545363-3	2022	The purpose of this study is to investigate the association between periconceptional folic acid supplement, the genetic polymorphisms of maternal folic acid receptor 1 gene (FOLR1) and folic acid receptor 2 gene (FOLR2) and the impact of their interaction on the risk of CHD in offspring, and to provide epidemiological evidence for individualized folic acid dosing in hygienic counseling.	Folic Acid	348-358	folate receptor alpha	Homo sapiens	174-179
35545363-3	2022	The purpose of this study is to investigate the association between periconceptional folic acid supplement, the genetic polymorphisms of maternal folic acid receptor 1 gene (FOLR1) and folic acid receptor 2 gene (FOLR2) and the impact of their interaction on the risk of CHD in offspring, and to provide epidemiological evidence for individualized folic acid dosing in hygienic counseling.	Folic Acid	348-358	folate receptor beta	Homo sapiens	213-218
35086087-2	2022	Dark green leafy vegetables contain folate as a main component among other nutrients; thus, we hypothesised that their possible observed protective effect on SCC, observed in previous studies, would be more evident in persons with specific genotypes related to folate metabolism.	Folic Acid	36-42	serpin family B member 3	Homo sapiens	158-161
35086087-2	2022	Dark green leafy vegetables contain folate as a main component among other nutrients; thus, we hypothesised that their possible observed protective effect on SCC, observed in previous studies, would be more evident in persons with specific genotypes related to folate metabolism.	Folic Acid	261-267	serpin family B member 3	Homo sapiens	158-161
35098008-5	2021	The polymorphic loci of folate cycle genes including rs1805087 5-methylenetetrahydrofolate (MTR) and rs1979277 serine hydroxymethyl transferase (SHMT1) were examined.	Folic Acid	24-30	serine hydroxymethyltransferase 1	Homo sapiens	145-150
35082830-3	2021	Gamma-glutamyl hydrolase (GGH) is a key enzyme in folate metabolism pathway.	Folic Acid	50-56	gamma-glutamyl hydrolase	Homo sapiens	0-24
35082830-3	2021	Gamma-glutamyl hydrolase (GGH) is a key enzyme in folate metabolism pathway.	Folic Acid	50-56	gamma-glutamyl hydrolase	Homo sapiens	26-29
2614501-5	1989	Some hypotheses on the mechanism(s) of (dl)-mTHF induced HL-60 cell differentiation are discussed with particular regard to a possible enhancement of lipid or DNA methylation via methionine formation by the (l) form or to inhibition of folate-dependent metabolism by the unnatural (d) form, hence of purine and thymine nucleotide synthesis.	Folic Acid	236-242	thin fur	Mus musculus	44-48
2586490-1	1989	Several structurally related series of folate analogs were studied as substrates for mouse liver folylpolyglutamate synthetase (FPGS).	Folic Acid	39-45	folylpolyglutamyl synthetase	Mus musculus	97-126
2586490-1	1989	Several structurally related series of folate analogs were studied as substrates for mouse liver folylpolyglutamate synthetase (FPGS).	Folic Acid	39-45	folylpolyglutamyl synthetase	Mus musculus	128-132
2586490-3	1989	A series of 2,4-diaminopyrimidine dihydrofolate reductase inhibitors were found to be substrates for FPGS; these are the first known compounds without a fused ring system analogous to the pteridine ring of the folate molecule that are substrates for FPGS.	Folic Acid	41-47	folylpolyglutamyl synthetase	Mus musculus	101-105
2586490-3	1989	A series of 2,4-diaminopyrimidine dihydrofolate reductase inhibitors were found to be substrates for FPGS; these are the first known compounds without a fused ring system analogous to the pteridine ring of the folate molecule that are substrates for FPGS.	Folic Acid	41-47	folylpolyglutamyl synthetase	Mus musculus	250-254
2586490-6	1989	It was concluded that neither the 2-amino group nor an intact pyrazine ring of folates and folate analogs are essential for the binding of folates to the active site of mouse liver FPGS but that the pyrazine ring probably serves to position other regions of the folate molecule that interact with amino acid residues in the active site.	Folic Acid	139-146	folylpolyglutamyl synthetase	Mus musculus	181-185
2586490-7	1989	It was also inferred from these observations that the volume within the active site of FPGS above/below the pyrazine ring or near the 10-position of folate derivatives are regions of limited bulk tolerance; binding of folate analogs with substituents at these positions probably distorts the active site.	Folic Acid	149-155	folylpolyglutamyl synthetase	Mus musculus	87-91
2586490-7	1989	It was also inferred from these observations that the volume within the active site of FPGS above/below the pyrazine ring or near the 10-position of folate derivatives are regions of limited bulk tolerance; binding of folate analogs with substituents at these positions probably distorts the active site.	Folic Acid	218-224	folylpolyglutamyl synthetase	Mus musculus	87-91
2768245-2	1989	The membrane-associated FBP is involved in the uptake of physiologic folates and methotrexate.	Folic Acid	69-76	folate receptor alpha	Homo sapiens	24-27
3190739-0	1988	Structural specificity of inhibition of human folylpolyglutamate synthetase by ornithine-containing folate analogs.	Folic Acid	100-106	folylpolyglutamate synthase	Homo sapiens	46-75
3190739-1	1988	A series of folate analogs containing ornithine instead of glutamate was synthesized and tested for inhibition of folylpolyglutamate synthetase (FPGS) and other folate-dependent enzymes of human leukemia cell lines.	Folic Acid	12-18	folylpolyglutamate synthase	Homo sapiens	114-143
3190739-1	1988	A series of folate analogs containing ornithine instead of glutamate was synthesized and tested for inhibition of folylpolyglutamate synthetase (FPGS) and other folate-dependent enzymes of human leukemia cell lines.	Folic Acid	12-18	folylpolyglutamate synthase	Homo sapiens	145-149
2843025-1	1988	The folate in milk is largely bound to high-affinity folate-binding protein (FBP).	Folic Acid	4-10	glycine N-methyltransferase	Rattus norvegicus	53-75
3366769-9	1988	The MTX-induced intracellular accumulation of 10-formyl-H2folate and H2folate may play a role in the drug-related cytotoxicity through the contribution of these folates to the inhibition of thymidylate synthase and de novo purine synthesis.	Folic Acid	161-168	thymidylate synthetase	Homo sapiens	190-210
2445177-9	1987	Our studies with thymidylate synthase from L. casei have shown that the bacterial enzyme also exhibits a greatly increased affinity for polyglutamate vs. monoglutamate derivatives of folic acid, and that reversal in the order of substrate addition and product release also occurs with polyglutamate as compared with monoglutamate substrates.	Folic Acid	183-193	thymidylate synthetase	Sus scrofa	17-37
3807889-1	1987	Folylpolyglutamate synthetase (FPGS) catalyzes the gamma-glutamylation of both folates and folate antagonists and has been found to be essential for the survival of mammalian cells.	Folic Acid	79-86	folylpolyglutamate synthase	Homo sapiens	0-29
3807889-1	1987	Folylpolyglutamate synthetase (FPGS) catalyzes the gamma-glutamylation of both folates and folate antagonists and has been found to be essential for the survival of mammalian cells.	Folic Acid	79-86	folylpolyglutamate synthase	Homo sapiens	31-35
3807889-1	1987	Folylpolyglutamate synthetase (FPGS) catalyzes the gamma-glutamylation of both folates and folate antagonists and has been found to be essential for the survival of mammalian cells.	Folic Acid	79-85	folylpolyglutamate synthase	Homo sapiens	0-29
3807889-1	1987	Folylpolyglutamate synthetase (FPGS) catalyzes the gamma-glutamylation of both folates and folate antagonists and has been found to be essential for the survival of mammalian cells.	Folic Acid	79-85	folylpolyglutamate synthase	Homo sapiens	31-35
2448651-1	1987	The activity of mouse-liver folylpolyglutamate synthetase (FPGS) was compared using a number of folates and folate analogs in order to determine which structure modifications were compatible with enzyme catalysis and with efficient binding to enzyme.	Folic Acid	96-103	folylpolyglutamyl synthetase	Mus musculus	28-57
2448651-1	1987	The activity of mouse-liver folylpolyglutamate synthetase (FPGS) was compared using a number of folates and folate analogs in order to determine which structure modifications were compatible with enzyme catalysis and with efficient binding to enzyme.	Folic Acid	96-102	folylpolyglutamyl synthetase	Mus musculus	28-57
2448651-4	1987	There was some correlation between FPGS substrate activity and the potency of folate antimetabolites as cytotoxic compounds but not necessarily as compounds selectively cytotoxic to tumor cells.	Folic Acid	78-84	folylpolyglutamate synthase	Homo sapiens	35-39
2448652-0	1987	Folate analog nonsubstrates and inhibitors of folylpolyglutamate synthetase as potential cancer chemotherapy drugs.	Folic Acid	0-6	folylpolyglutamate synthase	Homo sapiens	46-75
2448654-6	1987	Important elements in leucovorin rescue are reactivation of DHFR with depression of cellular dihydrofolate (FH2) and provision of folate substrate to circumvent the block in FH4 synthesis.	Folic Acid	100-106	dihydrofolate reductase	Homo sapiens	60-64
2829032-8	1987	Antisera against a folate-binding protein (FBP) blocked cell binding of folate and purified FBP also blocks cell binding of folate.	Folic Acid	19-25	folate receptor alpha	Homo sapiens	43-46
2829032-8	1987	Antisera against a folate-binding protein (FBP) blocked cell binding of folate and purified FBP also blocks cell binding of folate.	Folic Acid	19-25	folate receptor alpha	Homo sapiens	92-95
2829032-8	1987	Antisera against a folate-binding protein (FBP) blocked cell binding of folate and purified FBP also blocks cell binding of folate.	Folic Acid	72-78	folate receptor alpha	Homo sapiens	19-41
2829032-8	1987	Antisera against a folate-binding protein (FBP) blocked cell binding of folate and purified FBP also blocks cell binding of folate.	Folic Acid	72-78	folate receptor alpha	Homo sapiens	43-46
2963229-4	1987	The most probable mechanism of the interaction between folinic acid and the fluoropyrimidines is stabilization of thymidylate synthase (TS) in inactive complexes with 5-fluoro-2"-deoxyuridine-5"-monophosphate (FdUMP) and folate cofactor.	Folic Acid	221-227	thymidylate synthetase	Homo sapiens	114-134
3501543-1	1987	The active metabolite of FUra, 5-fluorodeoxyuridine monophosphate (5-FdUMP), requires the presence of reduced folates to form a covalent ternary complex with the target enzyme thymidylate synthase (TS).	Folic Acid	110-117	thymidylate synthetase	Homo sapiens	176-196
3501543-1	1987	The active metabolite of FUra, 5-fluorodeoxyuridine monophosphate (5-FdUMP), requires the presence of reduced folates to form a covalent ternary complex with the target enzyme thymidylate synthase (TS).	Folic Acid	110-117	thymidylate synthetase	Homo sapiens	198-200
2878641-10	1986	The results also suggest a role for human milk FBP in regulating the nutritional bioavailability of folate.	Folic Acid	100-106	folate receptor beta	Homo sapiens	47-50
3812977-1	1986	The enzyme folylpolyglutamate synthetase (FPGS) catalyzes the conversion of folate (pteroylmonoglutamate) to the polyglutamate forms (pteroylpolyglutamates) that are required for folate retention by mammalian cells.	Folic Acid	76-82	folylpolyglutamate synthase	Homo sapiens	42-46
3812977-1	1986	The enzyme folylpolyglutamate synthetase (FPGS) catalyzes the conversion of folate (pteroylmonoglutamate) to the polyglutamate forms (pteroylpolyglutamates) that are required for folate retention by mammalian cells.	Folic Acid	84-104	folylpolyglutamate synthase	Homo sapiens	42-46
3812977-1	1986	The enzyme folylpolyglutamate synthetase (FPGS) catalyzes the conversion of folate (pteroylmonoglutamate) to the polyglutamate forms (pteroylpolyglutamates) that are required for folate retention by mammalian cells.	Folic Acid	179-185	folylpolyglutamate synthase	Homo sapiens	42-46
2946653-3	1986	This increase in Pdi was essentially due to an increase in Ppl, since Pga and EMGdi had a linear relationship (r = 0.98, P less than 0.001) that did not change during the occlusive and ventilatory phases.	Folic Acid	70-73	peptidyl arginine deiminase 1	Homo sapiens	17-20
3466358-8	1986	Transformants with FPGS activity that showed a human enzyme preference for dATP also had folate polyglutamate chain lengths characteristic of the human enzyme.	Folic Acid	89-95	folylpolyglutamate synthase	Homo sapiens	19-23
3767384-6	1986	The association constants for pteroylglutamic acid of the FBPs in the 200,000 g cell lysate supernate, culture medium, and Triton-solubilized membrane were similar and the relative affinity of folate analogs for the FBP, vis-a-vis pteroylglutamic acid, was similar for all species.	Folic Acid	30-50	folate receptor beta	Homo sapiens	58-61
3767384-6	1986	The association constants for pteroylglutamic acid of the FBPs in the 200,000 g cell lysate supernate, culture medium, and Triton-solubilized membrane were similar and the relative affinity of folate analogs for the FBP, vis-a-vis pteroylglutamic acid, was similar for all species.	Folic Acid	193-199	folate receptor beta	Homo sapiens	58-61
3767384-6	1986	The association constants for pteroylglutamic acid of the FBPs in the 200,000 g cell lysate supernate, culture medium, and Triton-solubilized membrane were similar and the relative affinity of folate analogs for the FBP, vis-a-vis pteroylglutamic acid, was similar for all species.	Folic Acid	231-251	folate receptor beta	Homo sapiens	58-61
3767384-11	1986	After 16 weeks of culture in D medium, the total folate binding capacity of the membrane-associated FBP was twofold greater than that of normal KB cells, indicating the induction of FBP.	Folic Acid	49-55	folate receptor beta	Homo sapiens	100-103
3461471-8	1986	Binding of folate was inhibited by an antibody raised against a soluble plasma folate-binding protein, suggesting that the cell-surface receptor and the circulating folate-binding protein are immunologically related.	Folic Acid	11-17	folate receptor alpha	Homo sapiens	79-101
3461471-8	1986	Binding of folate was inhibited by an antibody raised against a soluble plasma folate-binding protein, suggesting that the cell-surface receptor and the circulating folate-binding protein are immunologically related.	Folic Acid	11-17	CD177 molecule	Homo sapiens	123-144
3461471-8	1986	Binding of folate was inhibited by an antibody raised against a soluble plasma folate-binding protein, suggesting that the cell-surface receptor and the circulating folate-binding protein are immunologically related.	Folic Acid	11-17	folate receptor alpha	Homo sapiens	165-187
3460637-6	1986	Both the purified folate-binding protein from the particulate fraction and the purified soluble form had higher affinity for oxidized folate than for the reduced folate cofactors, and both proteins had very low affinity for the antifolate compound, methotrexate.	Folic Acid	134-140	folate receptor alpha	Homo sapiens	18-40
3729988-1	1986	A specific high-affinity folate binding protein (FBP) that binds folic acid and folic acid derivatives and that was previously identified in porcine kidney has been purified 50,000-fold using the technique of affinity chromatography.	Folic Acid	65-75	folate receptor alpha	Homo sapiens	25-47
3729988-1	1986	A specific high-affinity folate binding protein (FBP) that binds folic acid and folic acid derivatives and that was previously identified in porcine kidney has been purified 50,000-fold using the technique of affinity chromatography.	Folic Acid	65-75	folate receptor alpha	Homo sapiens	49-52
3729988-1	1986	A specific high-affinity folate binding protein (FBP) that binds folic acid and folic acid derivatives and that was previously identified in porcine kidney has been purified 50,000-fold using the technique of affinity chromatography.	Folic Acid	80-90	folate receptor alpha	Homo sapiens	25-47
3729988-1	1986	A specific high-affinity folate binding protein (FBP) that binds folic acid and folic acid derivatives and that was previously identified in porcine kidney has been purified 50,000-fold using the technique of affinity chromatography.	Folic Acid	80-90	folate receptor alpha	Homo sapiens	49-52
3729988-6	1986	The FBP reacted more rapidly with unsubstituted folates, and the number of glutamic acid moieties (N greater than or equal to 1) did not influence binding.	Folic Acid	48-55	folate receptor alpha	Homo sapiens	4-7
3729988-7	1986	Binding of folic acid to the FBP was unaffected by a variety of anions and cations, and 8 M urea, but was disrupted by 6 M guanidine hydrochloride.	Folic Acid	11-21	folate receptor alpha	Homo sapiens	29-32
3756000-1	1986	Folylpolyglutamate synthetase (FPGS) catalyzes the synthesis of the poly-gamma-glutamate forms of tetrahydrofolate and its co-enzyme adducts, as well as of the folate-analogue drugs.	Folic Acid	108-114	folylpolyglutamate synthase	Homo sapiens	0-29
3756000-1	1986	Folylpolyglutamate synthetase (FPGS) catalyzes the synthesis of the poly-gamma-glutamate forms of tetrahydrofolate and its co-enzyme adducts, as well as of the folate-analogue drugs.	Folic Acid	108-114	folylpolyglutamate synthase	Homo sapiens	31-35
3088464-5	1986	Chronic valproate treatment affected the activities of folate-dependent one-carbon enzymes: Serine hydroxymethyltransferase activity in liver was increased; methylenetetrahydrofolate reductase activity in both brain and liver was decreased; and methyltetrahydrofolate:homocysteine methyltransferase activity in both brain and liver decreased initially but returned toward normal with continued treatment.	Folic Acid	55-61	methylenetetrahydrofolate reductase	Rattus norvegicus	157-192
3966077-12	1985	The greater concentration of folate binding protein in the renal tubule cell brush border membrane preparations as compared to those from basolateral membranes ascribes, for the first time, a functional role for folate binding protein in the renal reabsorption of folates which is required to prevent loss of folate in the urine and perhaps in the membrane transport of folates in general.	Folic Acid	264-271	glycine N-methyltransferase	Rattus norvegicus	29-51
3966077-12	1985	The greater concentration of folate binding protein in the renal tubule cell brush border membrane preparations as compared to those from basolateral membranes ascribes, for the first time, a functional role for folate binding protein in the renal reabsorption of folates which is required to prevent loss of folate in the urine and perhaps in the membrane transport of folates in general.	Folic Acid	264-271	glycine N-methyltransferase	Rattus norvegicus	212-234
3966077-12	1985	The greater concentration of folate binding protein in the renal tubule cell brush border membrane preparations as compared to those from basolateral membranes ascribes, for the first time, a functional role for folate binding protein in the renal reabsorption of folates which is required to prevent loss of folate in the urine and perhaps in the membrane transport of folates in general.	Folic Acid	29-35	glycine N-methyltransferase	Rattus norvegicus	212-234
3966077-12	1985	The greater concentration of folate binding protein in the renal tubule cell brush border membrane preparations as compared to those from basolateral membranes ascribes, for the first time, a functional role for folate binding protein in the renal reabsorption of folates which is required to prevent loss of folate in the urine and perhaps in the membrane transport of folates in general.	Folic Acid	370-377	glycine N-methyltransferase	Rattus norvegicus	29-51
3966077-12	1985	The greater concentration of folate binding protein in the renal tubule cell brush border membrane preparations as compared to those from basolateral membranes ascribes, for the first time, a functional role for folate binding protein in the renal reabsorption of folates which is required to prevent loss of folate in the urine and perhaps in the membrane transport of folates in general.	Folic Acid	370-377	glycine N-methyltransferase	Rattus norvegicus	212-234
6587377-3	1984	Purification of glycine N-methyltransferase resulted in the separation of two enzyme species, one that contained bound folate and one that did not.	Folic Acid	119-125	glycine N-methyltransferase	Rattus norvegicus	16-43
6427219-7	1984	Chloride ion was also found to lower the dissociation constant of the folic acid-FBP complex at 50 degrees C by about 10-fold.	Folic Acid	70-80	glycine N-methyltransferase	Rattus norvegicus	81-84
6427219-8	1984	This effect is thought to derive from the formation of a ternary FBP-folic acid-Cl- complex which is more stable than the binary FBP-folic acid complex.	Folic Acid	69-79	glycine N-methyltransferase	Rattus norvegicus	65-68
6427219-8	1984	This effect is thought to derive from the formation of a ternary FBP-folic acid-Cl- complex which is more stable than the binary FBP-folic acid complex.	Folic Acid	69-79	glycine N-methyltransferase	Rattus norvegicus	129-132
6427219-8	1984	This effect is thought to derive from the formation of a ternary FBP-folic acid-Cl- complex which is more stable than the binary FBP-folic acid complex.	Folic Acid	133-143	glycine N-methyltransferase	Rattus norvegicus	65-68
6427219-8	1984	This effect is thought to derive from the formation of a ternary FBP-folic acid-Cl- complex which is more stable than the binary FBP-folic acid complex.	Folic Acid	133-143	glycine N-methyltransferase	Rattus norvegicus	129-132
6351556-4	1983	Analog studies with thymidylate synthase suggest that there are two types of folate binding sites and this led us to propose a model for the subunit association.	Folic Acid	77-83	thymidylate synthetase	Homo sapiens	20-40
6897000-3	1982	This folate binding protein was initially identified during purification by an in vivo labeling procedure involving intraperitoneal injection of [3H]folic acid prior to sacrifice and subsequently by its ability to bind naturally reduced [3H]folate polyglutamates in vitro.	Folic Acid	145-159	glycine N-methyltransferase	Rattus norvegicus	5-27
33710891-0	2021	Folic Acid-Peptide Conjugates Combine Selective Cancer Cell Internalization with Thymidylate Synthase Dimer Interface Targeting.	Folic Acid	0-10	thymidylate synthetase	Homo sapiens	81-101
33710891-2	2021	Accordingly, we have designed conjugates of folic acid with anticancer peptides able to bind human thymidylate synthase (hTS) and enter cancer cells through folate receptor alpha (FRalpha) highly expressed by several cancer cells.	Folic Acid	44-54	thymidylate synthetase	Homo sapiens	99-119
33710891-2	2021	Accordingly, we have designed conjugates of folic acid with anticancer peptides able to bind human thymidylate synthase (hTS) and enter cancer cells through folate receptor alpha (FRalpha) highly expressed by several cancer cells.	Folic Acid	44-54	folate receptor alpha	Homo sapiens	157-178
33710891-2	2021	Accordingly, we have designed conjugates of folic acid with anticancer peptides able to bind human thymidylate synthase (hTS) and enter cancer cells through folate receptor alpha (FRalpha) highly expressed by several cancer cells.	Folic Acid	44-54	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	180-187
33737637-1	2021	There are three major folate uptake systems in human tissues and tumors, including the reduced folate carrier (RFC), folate receptors (FRs) and proton-coupled folate transporter (PCFT).	Folic Acid	22-28	solute carrier family 46 member 1	Homo sapiens	144-177
33737637-1	2021	There are three major folate uptake systems in human tissues and tumors, including the reduced folate carrier (RFC), folate receptors (FRs) and proton-coupled folate transporter (PCFT).	Folic Acid	22-28	solute carrier family 46 member 1	Homo sapiens	179-183
33737637-4	2021	We showed that cellular accumulations of extracellular folates were determined by the type and levels of the major folate transporters, with PCFT and RFC prevailing over FRalpha, depending on expression levels and pH.	Folic Acid	55-62	solute carrier family 46 member 1	Homo sapiens	141-145
33737637-4	2021	We showed that cellular accumulations of extracellular folates were determined by the type and levels of the major folate transporters, with PCFT and RFC prevailing over FRalpha, depending on expression levels and pH.	Folic Acid	55-62	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	170-177
33220403-10	2021	Expression of genes in cholesterol synthesis, transport or turnover (Abcg5, Abcg8, Abcc2, Cyp46a1, Hmgcs1) was perturbed by high folic acid intake.	Folic Acid	129-139	ATP binding cassette subfamily G member 8	Mus musculus	76-81
33220403-10	2021	Expression of genes in cholesterol synthesis, transport or turnover (Abcg5, Abcg8, Abcc2, Cyp46a1, Hmgcs1) was perturbed by high folic acid intake.	Folic Acid	129-139	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1	Mus musculus	99-105
33321684-6	2021	In addition, F-RAN was modified with folic acid to actively and selectively identify tumor cells.	Folic Acid	37-47	RAN, member RAS oncogene family	Homo sapiens	15-18
33419180-3	2021	Recent studies demonstrated that an alteration in HCY metabolism or a deficiency in folate or vitamin B12 can cause altered methylation and/or redox potentials, that leads to a modification on calcium influx in cells, or into an accumulation in amyloid and/or tau protein involving a cascade of events that culminate in apoptosis, and, in the worst conditions, neuronal death.	Folic Acid	84-90	microtubule associated protein tau	Homo sapiens	260-263
33220928-0	2021	Fluorofenidone attenuates renal fibrosis by inhibiting the mtROS-NLRP3 pathway in a murine model of folic acid nephropathy.	Folic Acid	100-110	NLR family, pyrin domain containing 3	Mus musculus	65-70
33220928-8	2021	In conclusion, this study demonstrated that AKF-PD inhibited renal fibrosis by suppressing the mtROS-NLRP3 pathway in the folic acid nephropathy model.	Folic Acid	122-132	NLR family, pyrin domain containing 3	Mus musculus	101-106
33302058-3	2021	Folate receptor 1 (Folr1) is a folate binding protein that facilitates the cellular uptake of dietary folate.	Folic Acid	31-37	folate receptor 1 (adult)	Mus musculus	0-17
33302058-3	2021	Folate receptor 1 (Folr1) is a folate binding protein that facilitates the cellular uptake of dietary folate.	Folic Acid	31-37	folate receptor 1 (adult)	Mus musculus	19-24
33302058-3	2021	Folate receptor 1 (Folr1) is a folate binding protein that facilitates the cellular uptake of dietary folate.	Folic Acid	102-108	folate receptor 1 (adult)	Mus musculus	0-17
33302058-3	2021	Folate receptor 1 (Folr1) is a folate binding protein that facilitates the cellular uptake of dietary folate.	Folic Acid	102-108	folate receptor 1 (adult)	Mus musculus	19-24
33160997-10	2021	Senescence-associated beta-galactosidase activity staining revealed that folic acid attenuated cardiac senescence by down-regulating p53/p21/p16 levels.	Folic Acid	73-83	galactosidase, beta 1	Mus musculus	22-40
33160997-10	2021	Senescence-associated beta-galactosidase activity staining revealed that folic acid attenuated cardiac senescence by down-regulating p53/p21/p16 levels.	Folic Acid	73-83	transformation related protein 53, pseudogene	Mus musculus	133-136
33126053-0	2021	Targeting feed-forward signaling of TGFbeta/NOX4/DHFR/eNOS uncoupling/TGFbeta axis with anti-TGFbeta and folic acid attenuates formation of aortic aneurysms: Novel mechanisms and therapeutics.	Folic Acid	105-115	transforming growth factor alpha	Mus musculus	36-43
33126053-0	2021	Targeting feed-forward signaling of TGFbeta/NOX4/DHFR/eNOS uncoupling/TGFbeta axis with anti-TGFbeta and folic acid attenuates formation of aortic aneurysms: Novel mechanisms and therapeutics.	Folic Acid	105-115	nitric oxide synthase 3, endothelial cell	Mus musculus	54-58
33126053-0	2021	Targeting feed-forward signaling of TGFbeta/NOX4/DHFR/eNOS uncoupling/TGFbeta axis with anti-TGFbeta and folic acid attenuates formation of aortic aneurysms: Novel mechanisms and therapeutics.	Folic Acid	105-115	transforming growth factor alpha	Mus musculus	70-77
33126053-4	2021	Intriguingly, oral administration with folic acid (FA) to recouple eNOS markedly alleviated expansion of aortic roots and abdominal aortas in Fbn1C1039G/+ mice, which was attributed to substantially upregulated DHFR expression and activity in the endothelium to restore tissue and circulating levels of H4B.	Folic Acid	39-49	nitric oxide synthase 3, endothelial cell	Mus musculus	67-71
33372619-0	2020	MicroRNA-302a is involved in folate deficiency-induced apoptosis through the AKT-FOXO1-BIM pathway in mouse embryonic stem cells.	Folic Acid	29-35	forkhead box O1	Mus musculus	81-86
33372619-11	2020	Real-time quantitative PCR and immunoblotting showed that in folate-free conditions, miR-302a and AKT were down regulated, while FOXO1 and Bim were up-regulated significantly.	Folic Acid	61-67	forkhead box O1	Mus musculus	129-134
33372619-12	2020	Additionally, treatment with LY294002 inhibitor revealed the involvement of the Akt/FOXO1/Bim signaling pathway in folate deficiency-induced apoptosis, rather than the ERK pathway.	Folic Acid	115-121	forkhead box O1	Mus musculus	84-89
33372619-14	2020	CONCLUSION: The involvement of miR-302a in folate deficiency-induced apoptosis through the AKT-FOXO1-BIM pathway in mESCs is a unique demonstration of the regulation mechanism of nutrient expression in embryonic development.	Folic Acid	43-49	forkhead box O1	Mus musculus	95-100
7097350-2	1982	Native state FBP recently has been shown to enhance the intestinal absorption of folacin, whereas the FBP of pasteurized milk is ineffective.	Folic Acid	81-88	folate receptor alpha	Bos taurus	13-16
427038-5	1979	Specific FBP thus functions to deliver folate to stores and represents a storage pool of folate.	Folic Acid	39-45	folate receptor beta	Homo sapiens	9-12
427038-5	1979	Specific FBP thus functions to deliver folate to stores and represents a storage pool of folate.	Folic Acid	89-95	folate receptor beta	Homo sapiens	9-12
427038-6	1979	The non-specific FBP are responsible for the delivery of folate to the fetus, and probably also to sites of utilization.	Folic Acid	57-63	folate receptor beta	Homo sapiens	17-20
958035-5	1976	A low folic serum acid level could induce minor neuropsychiatric symptoms while an additional low CSF folate could induce major neurological symptoms in spite of the presence of a normal erythrocyte folate level and in the absence of frank anemia.	Folic Acid	102-108	colony stimulating factor 2	Homo sapiens	98-101
958035-5	1976	A low folic serum acid level could induce minor neuropsychiatric symptoms while an additional low CSF folate could induce major neurological symptoms in spite of the presence of a normal erythrocyte folate level and in the absence of frank anemia.	Folic Acid	199-205	colony stimulating factor 2	Homo sapiens	98-101
814898-0	1976	Interaction of 13C-enriched folate with dihydrofolate reductase studies by carbon magnetic resonance spectroscopy.	Folic Acid	28-34	dihydrofolate reductase	Homo sapiens	40-63
8328990-1	1993	Folate-binding protein (FBP), a high-affinity folate receptor, is responsible for cellular accumulation of folate and folate analogs such as methotrexate in human KB (nasopharyngeal carcinoma) cells.	Folic Acid	46-52	folate receptor alpha	Homo sapiens	0-22
8328990-1	1993	Folate-binding protein (FBP), a high-affinity folate receptor, is responsible for cellular accumulation of folate and folate analogs such as methotrexate in human KB (nasopharyngeal carcinoma) cells.	Folic Acid	46-52	folate receptor alpha	Homo sapiens	24-27
8328990-1	1993	Folate-binding protein (FBP), a high-affinity folate receptor, is responsible for cellular accumulation of folate and folate analogs such as methotrexate in human KB (nasopharyngeal carcinoma) cells.	Folic Acid	107-113	folate receptor alpha	Homo sapiens	0-22
8328990-1	1993	Folate-binding protein (FBP), a high-affinity folate receptor, is responsible for cellular accumulation of folate and folate analogs such as methotrexate in human KB (nasopharyngeal carcinoma) cells.	Folic Acid	107-113	folate receptor alpha	Homo sapiens	24-27
8328990-2	1993	Both FBP and FBP mRNA increase 3- to 5-fold when KB cells are grown in folate-deficient (less than 10 nM folate) medium (KB-FD), compared with growth in standard folate-replete medium containing at least 2 microM folate (KB-FR).	Folic Acid	71-77	folate receptor alpha	Homo sapiens	5-8
8328990-2	1993	Both FBP and FBP mRNA increase 3- to 5-fold when KB cells are grown in folate-deficient (less than 10 nM folate) medium (KB-FD), compared with growth in standard folate-replete medium containing at least 2 microM folate (KB-FR).	Folic Acid	71-77	folate receptor alpha	Homo sapiens	13-16
8328990-2	1993	Both FBP and FBP mRNA increase 3- to 5-fold when KB cells are grown in folate-deficient (less than 10 nM folate) medium (KB-FD), compared with growth in standard folate-replete medium containing at least 2 microM folate (KB-FR).	Folic Acid	105-111	folate receptor alpha	Homo sapiens	5-8
8328990-2	1993	Both FBP and FBP mRNA increase 3- to 5-fold when KB cells are grown in folate-deficient (less than 10 nM folate) medium (KB-FD), compared with growth in standard folate-replete medium containing at least 2 microM folate (KB-FR).	Folic Acid	105-111	folate receptor alpha	Homo sapiens	13-16
8328990-2	1993	Both FBP and FBP mRNA increase 3- to 5-fold when KB cells are grown in folate-deficient (less than 10 nM folate) medium (KB-FD), compared with growth in standard folate-replete medium containing at least 2 microM folate (KB-FR).	Folic Acid	105-111	folate receptor alpha	Homo sapiens	5-8
8328990-2	1993	Both FBP and FBP mRNA increase 3- to 5-fold when KB cells are grown in folate-deficient (less than 10 nM folate) medium (KB-FD), compared with growth in standard folate-replete medium containing at least 2 microM folate (KB-FR).	Folic Acid	105-111	folate receptor alpha	Homo sapiens	13-16
8318019-5	1993	Folate binding to FBP results in significant changes in the c.d.	Folic Acid	0-6	folate receptor alpha	Bos taurus	18-21
8318019-8	1993	Folate binding also leads to strong quenching of FBP tryptophan fluorescence.	Folic Acid	0-6	folate receptor alpha	Bos taurus	49-52
8422641-6	1993	Moreover, these results show that the ratio of 5,10-methylenetetrahydrofolate concentration to thymidylate synthase concentration influences the thymidylate synthase inhibition rate in tumor, and that the new synthesis of 5,10-methylenetetrahydrofolate and tetrahydrofolate from other endogenous reduced folates is also important in tumors with high thymidylate synthase concentrations.	Folic Acid	304-311	thymidylate synthetase	Homo sapiens	95-115
8422641-6	1993	Moreover, these results show that the ratio of 5,10-methylenetetrahydrofolate concentration to thymidylate synthase concentration influences the thymidylate synthase inhibition rate in tumor, and that the new synthesis of 5,10-methylenetetrahydrofolate and tetrahydrofolate from other endogenous reduced folates is also important in tumors with high thymidylate synthase concentrations.	Folic Acid	304-311	thymidylate synthetase	Homo sapiens	145-165
8422641-6	1993	Moreover, these results show that the ratio of 5,10-methylenetetrahydrofolate concentration to thymidylate synthase concentration influences the thymidylate synthase inhibition rate in tumor, and that the new synthesis of 5,10-methylenetetrahydrofolate and tetrahydrofolate from other endogenous reduced folates is also important in tumors with high thymidylate synthase concentrations.	Folic Acid	304-311	thymidylate synthetase	Homo sapiens	145-165
22358703-2	1993	We have covalently linked a polylysine chain (10,000-20,000 mW) to compounds as folic acid, retinoic acid, transferrin, insulin and estradiol, to deliver c-myb antisense oligonucleotide into tumor cells.	Folic Acid	80-90	MYB proto-oncogene, transcription factor	Homo sapiens	154-159
7764059-2	1993	We have covalently linked a polylysine chain (10,000-20,000 mw) to compounds as folic acid, retinoic acid, transferrin, insulin and estradiol, to deliver c-myb antisense oligonucleotide into tumor cells.	Folic Acid	80-90	MYB proto-oncogene, transcription factor	Homo sapiens	154-159
8449831-1	1993	In order to clarify a molecular mechanism of folate resistance in leukemia cells, we studied alterations of the dihydrofolate reductase (DHFR) gene in a human leukemia cell line, MOLT-3, and its sublines made resistant to methotrexate (MTX), trimetrexate (TMQ) and N10-propargyl-5,8-dideazafolic acid (CB3717), alone or in combination.	Folic Acid	45-51	dihydrofolate reductase	Homo sapiens	137-141
8449831-8	1993	These data suggest that complex alterations of the DHFR gene are involved in the molecular mechanisms of folate resistance that can be differentially introduced into leukemia cells by exposure to various folate analogues, alone or in combination.	Folic Acid	105-111	dihydrofolate reductase	Homo sapiens	51-55
1084-1	1975	The low molecular weight folate binding protein (FABP) has been purified 1000-fold to a specific activity of 7.2 gamma g of pteroylglutamic acid (PGA) bound per mg of protein.	Folic Acid	124-144	folate receptor alpha	Homo sapiens	25-47
1084-1	1975	The low molecular weight folate binding protein (FABP) has been purified 1000-fold to a specific activity of 7.2 gamma g of pteroylglutamic acid (PGA) bound per mg of protein.	Folic Acid	124-144	folate receptor alpha	Homo sapiens	49-53
1084-1	1975	The low molecular weight folate binding protein (FABP) has been purified 1000-fold to a specific activity of 7.2 gamma g of pteroylglutamic acid (PGA) bound per mg of protein.	Folic Acid	146-149	folate receptor alpha	Homo sapiens	25-47
1084-1	1975	The low molecular weight folate binding protein (FABP) has been purified 1000-fold to a specific activity of 7.2 gamma g of pteroylglutamic acid (PGA) bound per mg of protein.	Folic Acid	146-149	folate receptor alpha	Homo sapiens	49-53
1084-2	1975	This purified FABP represents two protein bands that bind PGA on polyacrylamide disc gel electrophoreis, elutes from DEAE-cellulose in 0.001 M phosphate buffer, stains positive with PAS, Elutes from concanavalin A Sepharose affinity columns with methyl alpha-mannoside, and shows three major peaks (pl =6.8, 7.5, 8.2) by isotric focusing.	Folic Acid	58-61	folate receptor alpha	Homo sapiens	14-18
1084-3	1975	The binding of PGA to purified FABP dependent on pH and is inhibited by urea...	Folic Acid	15-18	folate receptor alpha	Homo sapiens	31-35
1106796-8	1975	The lower-molecular-weight folate binding protein shows reversible binding with partially and fully reduced folates but irreversible binding with oxidized folates.	Folic Acid	108-115	folate receptor alpha	Homo sapiens	27-49
1106796-8	1975	The lower-molecular-weight folate binding protein shows reversible binding with partially and fully reduced folates but irreversible binding with oxidized folates.	Folic Acid	155-162	folate receptor alpha	Homo sapiens	27-49
1106796-10	1975	The higher-molecular-weight folate binding protein, however, has only slight reversibility of binding with the partially and fully reduced folates, and it is therefore more difficult to postulate a physiologic function for this binding factor.	Folic Acid	139-146	folate receptor alpha	Homo sapiens	28-50
33957263-0	2021	Succinylsulfathiazole modulates the mTOR signaling pathway in the liver of c57BL/6 mice via a folate independent mechanism.	Folic Acid	94-100	mechanistic target of rapamycin kinase	Mus musculus	36-40
33957263-8	2021	This research sheds light on a possible confounding element when using SST to study folate depletion due to the potential overlap with multiple critical pathways such as mTOR.	Folic Acid	84-90	mechanistic target of rapamycin kinase	Mus musculus	170-174
33399929-8	2021	Folic acid in 2 mg/kg dose could moderately increase the serum folic acid concentration (15.75-19.95 ng/ml, p < 0.05), reduce the level of cystatin C (0.18-0.12 mug/L, p < 0.05), and had a tendency to improve the oxidative stress injury (OSI: 76.05-33.06, p > 0.05), although there was no statistical difference in TOS levels (p = 0.07).	Folic Acid	0-10	cystatin C	Rattus norvegicus	139-149
34002331-1	2021	Cerebral folate deficiency (CFD) syndrome is a rare treatable neurometabolic disorder with low levels of the active form of folaten in cerebrospinal fluid (CSF) arising from different causes such as FOLR1 gene mutations or autoantibodies against the folate receptor-alpha (FR) protein that can block folate transport across the choroid plexus.	Folic Acid	9-15	folate receptor alpha	Homo sapiens	199-204
34002331-1	2021	Cerebral folate deficiency (CFD) syndrome is a rare treatable neurometabolic disorder with low levels of the active form of folaten in cerebrospinal fluid (CSF) arising from different causes such as FOLR1 gene mutations or autoantibodies against the folate receptor-alpha (FR) protein that can block folate transport across the choroid plexus.	Folic Acid	9-15	folate receptor alpha	Homo sapiens	250-271
33979572-4	2021	Studies investigating the mechanism revealed that PGA diminished the binding efficiency of ETS family of transcription factor (ELK1) and Serum response factor (SRF), and suppressed ELK1-SRF complex-dependent transcription, which decreased the transcriptional levels of downstream genes Early growth response protein 1 (EGR1)-Polycomb ring finger (BMI1), thus inducing the imbalanced regulation between Myeloid cell leukaemia-1 (MCL1) and F-Box and WD repeat domain containing 7 (FBXW7).	Folic Acid	50-53	early growth response 1	Homo sapiens	286-317
33979572-4	2021	Studies investigating the mechanism revealed that PGA diminished the binding efficiency of ETS family of transcription factor (ELK1) and Serum response factor (SRF), and suppressed ELK1-SRF complex-dependent transcription, which decreased the transcriptional levels of downstream genes Early growth response protein 1 (EGR1)-Polycomb ring finger (BMI1), thus inducing the imbalanced regulation between Myeloid cell leukaemia-1 (MCL1) and F-Box and WD repeat domain containing 7 (FBXW7).	Folic Acid	50-53	early growth response 1	Homo sapiens	319-323
33979572-4	2021	Studies investigating the mechanism revealed that PGA diminished the binding efficiency of ETS family of transcription factor (ELK1) and Serum response factor (SRF), and suppressed ELK1-SRF complex-dependent transcription, which decreased the transcriptional levels of downstream genes Early growth response protein 1 (EGR1)-Polycomb ring finger (BMI1), thus inducing the imbalanced regulation between Myeloid cell leukaemia-1 (MCL1) and F-Box and WD repeat domain containing 7 (FBXW7).	Folic Acid	50-53	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	402-426
33979572-4	2021	Studies investigating the mechanism revealed that PGA diminished the binding efficiency of ETS family of transcription factor (ELK1) and Serum response factor (SRF), and suppressed ELK1-SRF complex-dependent transcription, which decreased the transcriptional levels of downstream genes Early growth response protein 1 (EGR1)-Polycomb ring finger (BMI1), thus inducing the imbalanced regulation between Myeloid cell leukaemia-1 (MCL1) and F-Box and WD repeat domain containing 7 (FBXW7).	Folic Acid	50-53	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	428-432
33979572-6	2021	We showed, for the first time, that the cytotoxic effects of PGA occurred by inducing MCL1 inhibition and FBXW7 activation by blocking ELK1-SRF complex-dependent transcription.	Folic Acid	61-64	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	86-90
33982476-5	2021	MTX-induced hepatotoxicity mechanisms include folate pathway, oxidative stress damage and adenosine pathway, of which oxidative stress theory is the main research direction.	Folic Acid	46-52	metaxin 1	Homo sapiens	0-3
33040301-5	2021	The outcome indicates that the inactivation of SAMdc results in a significant increase in fluxes through the methionine, the taurine and glutathione synthesis, and the folate cycles.	Folic Acid	168-174	adenosylmethionine decarboxylase 1	Homo sapiens	47-52
32588217-0	2021	Unmetabolized folic acid is associated with TNF-alpha, IL-1beta and IL-12 concentrations in a population exposed to mandatory food fortification with folic acid: a cross-sectional population-based study in Sao Paulo, Brazil.	Folic Acid	14-24	interleukin 1 alpha	Homo sapiens	55-63
33465052-5	2021	Cpt1a knock-in mice subjected to three different models of renal fibrosis (unilateral ureteral obstruction, folic acid nephropathy-FAN and adenine induced nephrotoxicity) exhibited decreased expression of fibrotic markers, a blunted pro-inflammatory response and reduced epithelial cell damage and macrophage influx.	Folic Acid	108-118	carnitine palmitoyltransferase 1a, liver	Mus musculus	0-5
33645547-4	2021	The researchers used knockout or conditional knockout animals to reduce Txndc5 expression, which reduced the accumulation of fibrous tissue in three models of chronic kidney disease (CKD), including unilateral ureteral obstruction, unilateral ischemia reperfusion injury, and folic acid nephropathy.	Folic Acid	276-286	thioredoxin domain containing 5	Homo sapiens	72-78
33670773-0	2021	Heterocyclic Substitutions Greatly Improve Affinity and Stability of Folic Acid towards FRalpha.	Folic Acid	69-79	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	88-95
33670773-3	2021	The folic acid (FA) binding affinity to the FRalpha active site provides a basis for designing more specific targets for FRalpha.	Folic Acid	4-14	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	44-51
33670773-3	2021	The folic acid (FA) binding affinity to the FRalpha active site provides a basis for designing more specific targets for FRalpha.	Folic Acid	4-14	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	121-128
33321157-6	2021	Folate-mediated targeting of FRbeta in M2 TAMs and NSCLC cells effectively inhibited tumor growth and the stimulus-responsive drug release reduced the toxic side effects of the drug.	Folic Acid	0-6	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	29-35
33203700-4	2021	This FRbeta+ subpopulation could be selectively targeted with folate-linked drugs.	Folic Acid	62-68	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	5-11
32618744-4	2021	In the last few years HER2/neu, folic acid-alpha (FRalpha) and Trop-2 overexpression have been exploited as excellent targets by novel ADCs such as Trastuzumab emtansine (T-DM1), SYD985, IMGN853 (Mirvetuximab soravtansine) and Sacituzumab govitecan (SG, IMMU-132) in multiple tumors including ovarian, endometrial and cervical cancers.	Folic Acid	32-42	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	50-57
33391382-0	2021	Variants of Genes Involved in Metabolism of Folate Among Patients with Breast Cancer: Association of TYMS 3R Allele with Susceptibility to Breast Cancer and Metastasis.	Folic Acid	44-50	thymidylate synthetase	Homo sapiens	101-105
33126053-0	2021	Targeting feed-forward signaling of TGFbeta/NOX4/DHFR/eNOS uncoupling/TGFbeta axis with anti-TGFbeta and folic acid attenuates formation of aortic aneurysms: Novel mechanisms and therapeutics.	Folic Acid	105-115	transforming growth factor alpha	Mus musculus	70-77
33311497-7	2020	These approaches identified GTP cyclohydrolase (GCH1) and folate metabolism as candidate mediators of alpha-synuclein neurotoxicity.	Folic Acid	58-64	synuclein alpha	Homo sapiens	102-117
33311497-8	2020	In functional validation studies, we found that the knockdown of Drosophila Gch1 enhanced locomotor deficits in alpha-synuclein transgenic flies, while folate supplementation protected from alpha-synuclein toxicity.	Folic Acid	152-158	synuclein alpha	Homo sapiens	190-205
32826232-0	2020	The Folate Cycle Enzyme MTHFR is a Critical Regulator of Cell Response to MYC-Targeting Therapies.	Folic Acid	4-10	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	74-77
32826232-2	2020	Here, we identify amino acid-related pathways connected to the folate cycle whose activation predicts sensitivity to MYC-targeting therapies in acute myeloid leukemia (AML).	Folic Acid	63-69	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	117-120
32826232-3	2020	We establish that folate restriction and deficiency of the rate-limiting folate cycle enzyme, MTHFR - which exhibits reduced-function polymorphisms in about 10% of Caucasians - induce resistance to MYC targeting by BET and CDK7 inhibitors in cell lines, primary patient samples, and syngeneic mouse models of AML.	Folic Acid	18-24	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	198-201
32826232-3	2020	We establish that folate restriction and deficiency of the rate-limiting folate cycle enzyme, MTHFR - which exhibits reduced-function polymorphisms in about 10% of Caucasians - induce resistance to MYC targeting by BET and CDK7 inhibitors in cell lines, primary patient samples, and syngeneic mouse models of AML.	Folic Acid	73-79	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	198-201
32826232-5	2020	Mechanistically, folate cycle disturbance reduces H3K27/K9 histone methylation and activates a SPI1 transcriptional program counteracting the effect of BET inhibition.	Folic Acid	17-23	Spi-1 proto-oncogene	Homo sapiens	95-99
32826232-6	2020	Our data provide a rationale for screening MTHFR polymorphisms and the folate cycle status to nominate patients most likely to benefit from MYC-targeting therapies.	Folic Acid	71-77	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	140-143
32975579-6	2020	This increase of SQOR induces the downregulation of the cystathionine beta-synthase and cystathionine gamma-lyase, two enzymes of the transsulfuration pathway, the subsequent downregulation of serine biosynthesis and the adaptation of other sulfide linked pathways, such as folate cycle, nucleotides metabolism and glutathione system.	Folic Acid	274-280	sulfide quinone oxidoreductase	Homo sapiens	17-21
32893190-1	2020	The proton-coupled folate transporter (PCFT, SLC46A1) is required for folate intestinal absorption and transport across the choroid plexus.	Folic Acid	19-25	solute carrier family 46 member 1	Homo sapiens	39-43
32893190-1	2020	The proton-coupled folate transporter (PCFT, SLC46A1) is required for folate intestinal absorption and transport across the choroid plexus.	Folic Acid	19-25	solute carrier family 46 member 1	Homo sapiens	45-52
33004416-0	2020	EBF1 and Pax5 safeguard leukemic transformation by limiting IL-7 signaling, Myc expression, and folate metabolism.	Folic Acid	96-102	EBF transcription factor 1	Homo sapiens	0-4
33004416-6	2020	Thus, EBF1 and Pax5 may safeguard early stage B cells from transformation to B-ALL by limiting IL-7 signaling, folate metabolism and Myc expression.	Folic Acid	111-117	early B cell factor 1	Mus musculus	6-10
33004416-6	2020	Thus, EBF1 and Pax5 may safeguard early stage B cells from transformation to B-ALL by limiting IL-7 signaling, folate metabolism and Myc expression.	Folic Acid	111-117	paired box 5	Mus musculus	15-19
32659629-6	2020	The data show that introducing long functional groups in folate will increase the binding affinity with FRalpha but will decrease the binding affinity with FRbeta.	Folic Acid	57-63	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	104-111
32659629-6	2020	The data show that introducing long functional groups in folate will increase the binding affinity with FRalpha but will decrease the binding affinity with FRbeta.	Folic Acid	57-63	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	156-162
32677119-1	2020	A novel folic acid functionalized terbium-doped dendritic fibrous nanoparticle (Tb@KCC-1-NH2 -FA) with high surface area was synthesized using a novel hydrothermal protocol.	Folic Acid	8-18	solute carrier family 12 member 4	Homo sapiens	83-88
33193126-13	2020	Based on the pathogen infection assay, tomato plants inoculated with cna1 or cnb1 mutant have a dramatic reduction in disease severity, indicating that calcineurin has a vital role in Fol virulence.	Folic Acid	184-187	protein phosphatase 3 regulatory subunit B, alpha	Homo sapiens	77-81
32726663-0	2020	Inhibition of CD73 using folate targeted nanoparticles carrying anti-CD73 siRNA potentiates anticancer efficacy of Dinaciclib.	Folic Acid	25-31	5' nucleotidase, ecto	Mus musculus	14-18
32726663-0	2020	Inhibition of CD73 using folate targeted nanoparticles carrying anti-CD73 siRNA potentiates anticancer efficacy of Dinaciclib.	Folic Acid	25-31	5' nucleotidase, ecto	Mus musculus	69-73
32726663-7	2020	So in this study, we intended to simultaneously suppress CD73 and CDKs in cancer cells by using the folic acid (FA)-conjugated chitosan-lactate (CL) NPs loaded with anti-CD73 siRNA and Dinaciclib to control tumor progression and metastasis.	Folic Acid	100-110	5' nucleotidase, ecto	Mus musculus	57-61
32726663-7	2020	So in this study, we intended to simultaneously suppress CD73 and CDKs in cancer cells by using the folic acid (FA)-conjugated chitosan-lactate (CL) NPs loaded with anti-CD73 siRNA and Dinaciclib to control tumor progression and metastasis.	Folic Acid	100-110	5' nucleotidase, ecto	Mus musculus	170-174
32892962-5	2020	One of these abnormalities involves a partial blockage in the ability of folate to be transported into the brain utilizing the primary transport mechanism, the folate receptor alpha.	Folic Acid	73-79	folate receptor alpha	Homo sapiens	160-181
32892962-6	2020	Autoantibodies which interfere with the function of the folate receptor alpha called folate receptor alpha autoantibodies have been identified in 58%-76% of children with ASD and independent studies have demonstrated that blood titers of these autoantibodies correlate with folate levels in the cerebrospinal fluid.	Folic Acid	56-62	folate receptor alpha	Homo sapiens	85-106
32892962-7	2020	Most significantly, case-series, open-label, and single and double-blind placebo-controlled studies suggest that d,l-leucovorin, a reduced folate that can bypass the blockage at the folate receptor alpha by using the reduced folate carrier, an alternate pathway, can substantially improve particular symptoms in children with ASD, especially those positive for folate receptor alpha autoantibodies.	Folic Acid	139-145	folate receptor alpha	Homo sapiens	182-203
32892962-7	2020	Most significantly, case-series, open-label, and single and double-blind placebo-controlled studies suggest that d,l-leucovorin, a reduced folate that can bypass the blockage at the folate receptor alpha by using the reduced folate carrier, an alternate pathway, can substantially improve particular symptoms in children with ASD, especially those positive for folate receptor alpha autoantibodies.	Folic Acid	139-145	folate receptor alpha	Homo sapiens	361-382
32957872-0	2021	Protective Potential of Uric Acid, Folic Acid, Glutathione and Ascorbic Acid against the Formation of Toxic Met-Myoglobin.	Folic Acid	35-45	myoglobin	Homo sapiens	112-121
32957872-6	2021	Spectroscopic analysis was used to identify the protective potential of uric acid, folic acid, glutathione and ascorbic acid against the formation of met-myoglobin.	Folic Acid	83-93	myoglobin	Homo sapiens	154-163
32957872-7	2021	RESULTS: The novel data of this study showed that H2O2 induced extensive damage of myoglobin but the treatment with uric acid, folic acid, glutathione or ascorbic acid provides protection of myoglobin against H2O2 induced oxidative damaged.	Folic Acid	127-137	myoglobin	Homo sapiens	191-200
32701510-5	2020	Conversely, the overexpression of WT HIPK2 in RTECs accentuated the extent of renal fibrosis in the setting of UUO, HIVAN, and folic acid nephropathy (FAN) in mice.	Folic Acid	127-137	homeodomain interacting protein kinase 2	Mus musculus	37-42
32820034-2	2021	Mutations in several folate pathway genes, including FOLR1 (folate receptor alpha, FRalpha), DHFR (dihydrofolate reductase) and PCFT (proton coupled folate transporter) have been previously identified in patients with CFD.Methods In an effort to identify causal mutations for CFD, we performed whole exome sequencing analysis on eight CFD trios and identified eight de novo mutations in seven trios.Results Notably, we found a de novo stop gain mutation in the capicua (CIC) gene.	Folic Acid	21-27	folate receptor alpha	Homo sapiens	53-58
32820034-2	2021	Mutations in several folate pathway genes, including FOLR1 (folate receptor alpha, FRalpha), DHFR (dihydrofolate reductase) and PCFT (proton coupled folate transporter) have been previously identified in patients with CFD.Methods In an effort to identify causal mutations for CFD, we performed whole exome sequencing analysis on eight CFD trios and identified eight de novo mutations in seven trios.Results Notably, we found a de novo stop gain mutation in the capicua (CIC) gene.	Folic Acid	21-27	folate receptor alpha	Homo sapiens	60-81
32820034-2	2021	Mutations in several folate pathway genes, including FOLR1 (folate receptor alpha, FRalpha), DHFR (dihydrofolate reductase) and PCFT (proton coupled folate transporter) have been previously identified in patients with CFD.Methods In an effort to identify causal mutations for CFD, we performed whole exome sequencing analysis on eight CFD trios and identified eight de novo mutations in seven trios.Results Notably, we found a de novo stop gain mutation in the capicua (CIC) gene.	Folic Acid	21-27	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	83-90
32820034-2	2021	Mutations in several folate pathway genes, including FOLR1 (folate receptor alpha, FRalpha), DHFR (dihydrofolate reductase) and PCFT (proton coupled folate transporter) have been previously identified in patients with CFD.Methods In an effort to identify causal mutations for CFD, we performed whole exome sequencing analysis on eight CFD trios and identified eight de novo mutations in seven trios.Results Notably, we found a de novo stop gain mutation in the capicua (CIC) gene.	Folic Acid	21-27	dihydrofolate reductase	Homo sapiens	93-97
32820034-2	2021	Mutations in several folate pathway genes, including FOLR1 (folate receptor alpha, FRalpha), DHFR (dihydrofolate reductase) and PCFT (proton coupled folate transporter) have been previously identified in patients with CFD.Methods In an effort to identify causal mutations for CFD, we performed whole exome sequencing analysis on eight CFD trios and identified eight de novo mutations in seven trios.Results Notably, we found a de novo stop gain mutation in the capicua (CIC) gene.	Folic Acid	21-27	dihydrofolate reductase	Homo sapiens	99-122
32820034-2	2021	Mutations in several folate pathway genes, including FOLR1 (folate receptor alpha, FRalpha), DHFR (dihydrofolate reductase) and PCFT (proton coupled folate transporter) have been previously identified in patients with CFD.Methods In an effort to identify causal mutations for CFD, we performed whole exome sequencing analysis on eight CFD trios and identified eight de novo mutations in seven trios.Results Notably, we found a de novo stop gain mutation in the capicua (CIC) gene.	Folic Acid	21-27	solute carrier family 46 member 1	Homo sapiens	128-132
32820034-2	2021	Mutations in several folate pathway genes, including FOLR1 (folate receptor alpha, FRalpha), DHFR (dihydrofolate reductase) and PCFT (proton coupled folate transporter) have been previously identified in patients with CFD.Methods In an effort to identify causal mutations for CFD, we performed whole exome sequencing analysis on eight CFD trios and identified eight de novo mutations in seven trios.Results Notably, we found a de novo stop gain mutation in the capicua (CIC) gene.	Folic Acid	21-27	solute carrier family 46 member 1	Homo sapiens	134-167
32820034-4	2021	Functional analysis indicates that CIC binds to an octameric sequence in the promoter regions of folate transport genes: FOLR1, PCFT and reduced folate carrier (Slc19A1; RFC1).	Folic Acid	97-103	folate receptor alpha	Homo sapiens	121-126
32820034-4	2021	Functional analysis indicates that CIC binds to an octameric sequence in the promoter regions of folate transport genes: FOLR1, PCFT and reduced folate carrier (Slc19A1; RFC1).	Folic Acid	97-103	solute carrier family 46 member 1	Homo sapiens	128-132
32820034-6	2021	Folate binding assay demonstrated that the p.R353X variant decreased cellular binding of folic acid in cells.Conclusion This study indicates that CIC loss of function variants can contribute to the genetic aetiology of CFD through regulating FOLR1 expression.	Folic Acid	0-6	folate receptor alpha	Homo sapiens	242-247
32820034-6	2021	Folate binding assay demonstrated that the p.R353X variant decreased cellular binding of folic acid in cells.Conclusion This study indicates that CIC loss of function variants can contribute to the genetic aetiology of CFD through regulating FOLR1 expression.	Folic Acid	89-99	folate receptor alpha	Homo sapiens	242-247
32543769-2	2020	Folate transport across biological membranes is mediated by three major pathways: folate receptor alpha (FRalpha), proton-coupled folate transporter (PCFT), and reduced folate carrier (RFC).	Folic Acid	0-6	folate receptor 1 (adult)	Mus musculus	82-103
32319147-1	2020	OBJECTIVE: DHFR encodes dihydrofolate reductase, a major enzyme in the metabolism of folate, and is a candidate gene for ischemic stroke (IS).	Folic Acid	31-37	dihydrofolate reductase	Homo sapiens	11-15
32765812-0	2020	Folic acid supplementation prevents high fructose-induced non-alcoholic fatty liver disease by activating the AMPK and LKB1 signaling pathways.	Folic Acid	0-10	serine/threonine kinase 11	Rattus norvegicus	119-123
32765812-6	2020	Moreover, folic acid supplementation in rats fed high fructose enhanced the levels of phosphorylated AMP-activated protein kinase (AMPK) and liver kinase B (LKB1) and inhibited phosphorylation of acetyl coenzyme A carboxylase (ACC) in the liver.	Folic Acid	10-20	serine/threonine kinase 11	Rattus norvegicus	157-161
32765812-7	2020	CONCLUSIONS: These results suggest that the protective effect of folic acid supplementation in rats fed high fructose may include the activation of LKB1/AMPK/ACC and increased SAM in the liver, which inhibit hepatic lipogenesis, thus ameliorating hepatic steatosis.	Folic Acid	65-75	serine/threonine kinase 11	Rattus norvegicus	148-152
32315999-6	2020	After the confirmation of their high fluorescence photostability, the NPs were covalently conjugated with folic acid (HSA-FA NPs) in order to bind specifically to the folate receptor alpha (FRalpha) protein overexpressed on NIH:OVCAR3 ovarian cancer cells.	Folic Acid	106-116	folate receptor alpha	Homo sapiens	167-188
32315999-6	2020	After the confirmation of their high fluorescence photostability, the NPs were covalently conjugated with folic acid (HSA-FA NPs) in order to bind specifically to the folate receptor alpha (FRalpha) protein overexpressed on NIH:OVCAR3 ovarian cancer cells.	Folic Acid	106-116	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	190-197
31712157-2	2020	In the present work, folic acid-conjugated chitosan-functionalized graphene oxide (FA-CS-GO) has been developed as a new type of multifunctional nanomaterial for near-infrared fluorescence (FL)/photoacoustic imaging-(PAI) guided photothermal therapy (PTT) of cancer.	Folic Acid	21-31	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	217-220
31751728-0	2020	Inhibition of Tau amyloid fibril formation by folic acid: In-vitro and theoretical studies.	Folic Acid	46-56	microtubule associated protein tau	Homo sapiens	14-17
31751728-5	2020	We investigated the interaction between folic acid and Tau protein, then experimental and theoretical evidence were provided for the suppressing effects of folic acid on Tau fibril formation.	Folic Acid	156-166	microtubule associated protein tau	Homo sapiens	170-173
31751728-6	2020	The obtained results showed that folic acid could interact with Tau through a spontaneous binding process, mainly by hydrophobic forces, and this interaction leads to a decline in protein-protein interactions through stabilizing its native state, limiting successful Tau-seed oligomerization and consequently decelerating polymerization of Tau amyloid aggregates.	Folic Acid	33-43	microtubule associated protein tau	Homo sapiens	64-67
31751728-6	2020	The obtained results showed that folic acid could interact with Tau through a spontaneous binding process, mainly by hydrophobic forces, and this interaction leads to a decline in protein-protein interactions through stabilizing its native state, limiting successful Tau-seed oligomerization and consequently decelerating polymerization of Tau amyloid aggregates.	Folic Acid	33-43	microtubule associated protein tau	Homo sapiens	267-270
31751728-6	2020	The obtained results showed that folic acid could interact with Tau through a spontaneous binding process, mainly by hydrophobic forces, and this interaction leads to a decline in protein-protein interactions through stabilizing its native state, limiting successful Tau-seed oligomerization and consequently decelerating polymerization of Tau amyloid aggregates.	Folic Acid	33-43	microtubule associated protein tau	Homo sapiens	267-270
32271909-0	2020	p53 Disruption Increases Uracil Accumulation in DNA of Murine Embryonic Fibroblasts and Leads to Folic Acid-Nonresponsive Neural Tube Defects in Mice.	Folic Acid	97-107	transformation related protein 53, pseudogene	Mus musculus	0-3
32271909-11	2020	p53-/- MEFs had 55% higher rates of folate-dependent de novo dTMP synthesis, a ~2-fold higher accumulation of uracil in DNA, and a ~30% higher rate of proliferation (P <= 0.05) than p53+/- MEFs independent of folate.	Folic Acid	36-42	transformation related protein 53, pseudogene	Mus musculus	0-3
32271909-11	2020	p53-/- MEFs had 55% higher rates of folate-dependent de novo dTMP synthesis, a ~2-fold higher accumulation of uracil in DNA, and a ~30% higher rate of proliferation (P <= 0.05) than p53+/- MEFs independent of folate.	Folic Acid	209-215	transformation related protein 53, pseudogene	Mus musculus	0-3
32748352-1	2020	In this paper, folic acid-coated graphene oxide nanocomposite (FA-GO) is used as an adsorbent for the treatment of heavy metals including cadmium (Cd2+) and copper (Cu2+) ions.	Folic Acid	15-25	CD2 molecule	Homo sapiens	147-150
33164984-3	2020	The folate pathway genes SLC19A1, ABCC1, ABCC4, FPGS, and MTHFD1 significantly influenced intracellular MTXPG levels (P = 2.9 x 10-3 to 3.7 x 10-8).	Folic Acid	4-10	folylpolyglutamate synthase	Homo sapiens	48-52
33084315-1	2020	Folic acid (FA) has been extensively exploited to facilitate targeted delivery of nanomedicines by recognizing the folate receptor-alpha (FR-alpha) overexpressed in many human cancers.	Folic Acid	0-10	folate receptor alpha	Homo sapiens	115-136
33084315-1	2020	Folic acid (FA) has been extensively exploited to facilitate targeted delivery of nanomedicines by recognizing the folate receptor-alpha (FR-alpha) overexpressed in many human cancers.	Folic Acid	0-10	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	138-146
32829070-1	2020	Folate receptor alpha (FRalpha) is a membrane-bound protein with a high affinity for folate, which is necessary for the biosynthesis of amino acids and nucleotide bases.	Folic Acid	85-91	folate receptor alpha	Homo sapiens	0-21
32829070-1	2020	Folate receptor alpha (FRalpha) is a membrane-bound protein with a high affinity for folate, which is necessary for the biosynthesis of amino acids and nucleotide bases.	Folic Acid	85-91	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	23-30
32885649-5	2020	The synthesized folate (FA)/Pt-si-GPX4@IONPs exerted substantial effects on glioblastoma in U87MG and P3#GBM cells, but limited effects on normal human astrocytes (NHAs).	Folic Acid	16-22	glutathione peroxidase 4	Homo sapiens	34-38
32915913-10	2020	Genes, including Ttc38, Sema3A, Insl3, Dll1, Msh4 and Snai1, were the novel factors that may be associated with the development of the kidneys and related to folic acid treatment.	Folic Acid	158-168	insulin-like 3	Mus musculus	32-37
32915913-10	2020	Genes, including Ttc38, Sema3A, Insl3, Dll1, Msh4 and Snai1, were the novel factors that may be associated with the development of the kidneys and related to folic acid treatment.	Folic Acid	158-168	delta like canonical Notch ligand 1	Mus musculus	39-43
32612964-2	2020	The pharmacodynamics of Mtx depends on the polymorphism of genes encoding proteins engaged in the folate metabolism pathway.	Folic Acid	98-104	metaxin 1	Homo sapiens	24-27
32612964-3	2020	The aim of the current study is to determine the relationship between variants of folate metabolism-related genes and the frequency of acute toxicities of HD-Mtx.	Folic Acid	82-88	metaxin 1	Homo sapiens	158-161
32582152-4	2020	Methods: We prepared a multi-functional gold nanorod reagent, GMPF-siIDO, that is composed of gold nanorods (GNRs) that act as the nano-platform and photothermal sensitizer; folic acid (FA) as the tumor-targeting moiety; and IDO-specific RNA (siIDO) as an immune-stimulator functionality for inducing anti-tumor immunity.	Folic Acid	174-184	indoleamine 2,3-dioxygenase 1	Homo sapiens	69-72
32512783-0	2020	Spectroscopic and Molecular Modeling Investigation on the Interaction between Folic Acid and Bovine Lactoferrin from Encapsulation Perspectives.	Folic Acid	78-88	lactotransferrin	Bos taurus	100-111
32512783-1	2020	The impact of thermal treatment on the ability of lactoferrin (FL) to bind folic acid (FA) was investigated by employing fluorescence spectroscopy, molecular dynamics and docking tests.	Folic Acid	75-85	lactotransferrin	Bos taurus	50-61
32503320-7	2020	The results show that a relatively high concentration of folic acid functionalization of the nanostructured silica together with the incorporation of the cytotoxic tin fragment leads to an increase in the quantity of the soluble FOLR1 secreted by the tumour cells.	Folic Acid	57-67	folate receptor alpha	Homo sapiens	229-234
32173264-8	2020	Stress response of neurons indicated as c-Fos expression was also reduced in the DG of low folate diet-fed mice.	Folic Acid	91-97	FBJ osteosarcoma oncogene	Mus musculus	42-45
32152484-2	2020	Binding to FRalpha is one of several methods by which folate is taken up by cells; however, this receptor is an attractive anticancer drug target owing to the overexpression of FRalpha in a range of solid tumours, including ovarian, lung and breast cancers.	Folic Acid	54-60	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	11-18
32152484-2	2020	Binding to FRalpha is one of several methods by which folate is taken up by cells; however, this receptor is an attractive anticancer drug target owing to the overexpression of FRalpha in a range of solid tumours, including ovarian, lung and breast cancers.	Folic Acid	54-60	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	177-184
32142918-8	2020	Similar to its family member SHMT2, SHMT1 plays a crucial role in folate-dependent serine/glycine inter-conversion in one-carbon metabolism.	Folic Acid	66-72	serine hydroxymethyltransferase 1	Homo sapiens	36-41
32581311-2	2020	While several studies have reported that FOLR1 and FOLR2 import folic acid into cells, the role of FOLR3 remains unknown.	Folic Acid	64-74	folate receptor alpha	Homo sapiens	41-46
32581311-2	2020	While several studies have reported that FOLR1 and FOLR2 import folic acid into cells, the role of FOLR3 remains unknown.	Folic Acid	64-74	folate receptor beta	Homo sapiens	51-56
32154964-0	2020	Folate-appended cyclodextrin carrier targets ovarian cancer cells expressing the proton-coupled folate transporter.	Folic Acid	0-6	solute carrier family 46 member 1	Homo sapiens	81-114
8449831-8	1993	These data suggest that complex alterations of the DHFR gene are involved in the molecular mechanisms of folate resistance that can be differentially introduced into leukemia cells by exposure to various folate analogues, alone or in combination.	Folic Acid	204-210	dihydrofolate reductase	Homo sapiens	51-55
32256983-2	2020	Intracellular folate homeostasis is maintained by the enzymes folylpolyglutamate synthase (FPGS) and gamma-glutamyl hydrolase (GGH).	Folic Acid	14-20	folylpolyglutamate synthase	Homo sapiens	62-89
32256983-2	2020	Intracellular folate homeostasis is maintained by the enzymes folylpolyglutamate synthase (FPGS) and gamma-glutamyl hydrolase (GGH).	Folic Acid	14-20	folylpolyglutamate synthase	Homo sapiens	91-95
1426244-0	1992	13C NMR studies of complexes of Escherichia coli dihydrofolate reductase formed with methotrexate and with folic acid.	Folic Acid	107-117	Dihydrofolate reductase	Escherichia coli	49-72
32256983-2	2020	Intracellular folate homeostasis is maintained by the enzymes folylpolyglutamate synthase (FPGS) and gamma-glutamyl hydrolase (GGH).	Folic Acid	14-20	gamma-glutamyl hydrolase	Homo sapiens	101-125
32256983-2	2020	Intracellular folate homeostasis is maintained by the enzymes folylpolyglutamate synthase (FPGS) and gamma-glutamyl hydrolase (GGH).	Folic Acid	14-20	gamma-glutamyl hydrolase	Homo sapiens	127-130
32256983-3	2020	FPGS adds glutamate residues to folate upon its entry into the cell through a process known as polyglutamylation to enhance folate retention in the cell and to maintain a steady supply of utilizable folate derivatives for folate-dependent enzyme reactions.	Folic Acid	32-38	folylpolyglutamate synthase	Homo sapiens	0-4
32256983-3	2020	FPGS adds glutamate residues to folate upon its entry into the cell through a process known as polyglutamylation to enhance folate retention in the cell and to maintain a steady supply of utilizable folate derivatives for folate-dependent enzyme reactions.	Folic Acid	124-130	folylpolyglutamate synthase	Homo sapiens	0-4
32256983-3	2020	FPGS adds glutamate residues to folate upon its entry into the cell through a process known as polyglutamylation to enhance folate retention in the cell and to maintain a steady supply of utilizable folate derivatives for folate-dependent enzyme reactions.	Folic Acid	124-130	folylpolyglutamate synthase	Homo sapiens	0-4
1360212-6	1992	Sulfasalazine inhibited 26.2% of the total flux of MTX, in close agreement with the fraction of MTX flux that has been shown previously to be inhibited by folic acid.	Folic Acid	155-165	metaxin 1	Homo sapiens	51-54
32256983-3	2020	FPGS adds glutamate residues to folate upon its entry into the cell through a process known as polyglutamylation to enhance folate retention in the cell and to maintain a steady supply of utilizable folate derivatives for folate-dependent enzyme reactions.	Folic Acid	124-130	folylpolyglutamate synthase	Homo sapiens	0-4
32256983-4	2020	Thereafter, GGH catalyzes the hydrolysis of polyglutamylated folate into monoglutamylated folate, which can subsequently be exported from the cell.	Folic Acid	61-67	gamma-glutamyl hydrolase	Homo sapiens	12-15
32256983-4	2020	Thereafter, GGH catalyzes the hydrolysis of polyglutamylated folate into monoglutamylated folate, which can subsequently be exported from the cell.	Folic Acid	90-96	gamma-glutamyl hydrolase	Homo sapiens	12-15
32256983-9	2020	Therefore, FPGS and GGH affect chemosensitivity to antifolates and 5-fluorouracil by altering intracellular retention status of antifolates and folate cofactors such as 5,10-methylenetetrahydrofolate, subsequently influencing the cytotoxic effects of 5-fluorouracil, respectively.	Folic Acid	55-61	folylpolyglutamate synthase	Homo sapiens	11-15
32256983-9	2020	Therefore, FPGS and GGH affect chemosensitivity to antifolates and 5-fluorouracil by altering intracellular retention status of antifolates and folate cofactors such as 5,10-methylenetetrahydrofolate, subsequently influencing the cytotoxic effects of 5-fluorouracil, respectively.	Folic Acid	55-61	gamma-glutamyl hydrolase	Homo sapiens	20-23
1360212-6	1992	Sulfasalazine inhibited 26.2% of the total flux of MTX, in close agreement with the fraction of MTX flux that has been shown previously to be inhibited by folic acid.	Folic Acid	155-165	metaxin 1	Homo sapiens	96-99
1427091-5	1992	The inability of the mutants to metabolize FA suggests that the DFR1 gene product may have a role in folate metabolism in addition to its well-characterized function in the reduction of dihydrofolate.	Folic Acid	101-107	dihydrofolate reductase	Saccharomyces cerevisiae S288C	64-68
32193457-11	2020	DNA methylation level in POU5F1 promoter and ICR of H19 and IGF2 of SCNT derived embryos in the folate- group was similar to the IVF derived blastocysts.	Folic Acid	96-102	POU class 5 homeobox 1	Homo sapiens	25-31
32193457-11	2020	DNA methylation level in POU5F1 promoter and ICR of H19 and IGF2 of SCNT derived embryos in the folate- group was similar to the IVF derived blastocysts.	Folic Acid	96-102	insulin like growth factor 2	Homo sapiens	60-64
1482756-7	1992	In conclusion, the induction of clusterin after folic acid administration or subtotal nephrectomy was independent of the presence of an intact complement system, because similar increases in clusterin expression were observed in C5-sufficient and C5-deficient mice.	Folic Acid	48-58	clusterin	Mus musculus	32-41
32033374-3	2020	However, the association between the over-expression of the Folate Receptor Alpha (FRA) in TNBC and other cancer cells, has led to the possibility that TNBCs might be treated by targeting the FRA with redox selenium covalent Folic Acid conjugates.	Folic Acid	225-235	folate receptor alpha	Homo sapiens	60-81
32033374-3	2020	However, the association between the over-expression of the Folate Receptor Alpha (FRA) in TNBC and other cancer cells, has led to the possibility that TNBCs might be treated by targeting the FRA with redox selenium covalent Folic Acid conjugates.	Folic Acid	225-235	folate receptor alpha	Homo sapiens	83-86
32033374-3	2020	However, the association between the over-expression of the Folate Receptor Alpha (FRA) in TNBC and other cancer cells, has led to the possibility that TNBCs might be treated by targeting the FRA with redox selenium covalent Folic Acid conjugates.	Folic Acid	225-235	folate receptor alpha	Homo sapiens	192-195
32028640-5	2020	Given the systemic toxicity of l-BSO, we developed a new formulation using polyurea (PURE) dendrimers nanoparticles (l-BSO@PUREG4-FA2), targeting l-BSO delivery in a folate functionalized nanoparticle.	Folic Acid	166-172	FA complementation group B	Homo sapiens	130-133
31936786-5	2020	This photosensitizer is associated with an addressing molecule (folic acid) targeting the folate receptor 1 (FOLR1) with a high affinity.	Folic Acid	64-74	folate receptor 1 (adult)	Mus musculus	90-107
31936786-5	2020	This photosensitizer is associated with an addressing molecule (folic acid) targeting the folate receptor 1 (FOLR1) with a high affinity.	Folic Acid	64-74	folate receptor 1 (adult)	Mus musculus	109-114
31936786-6	2020	Folate binds to FOLR1, in a specific way, expressed in 100% of ADKP or over-expressed in 30% of cases.	Folic Acid	0-6	folate receptor 1 (adult)	Mus musculus	16-21
31816239-0	2020	Polydopamine-PEG-Folic Acid Conjugate Film Engineered TiO2 Nanotube Arrays for Photoelectrochemical Sensing of Folate Binding Protein.	Folic Acid	17-27	folate receptor alpha	Homo sapiens	111-133
31816239-6	2020	The incorporation of folic acid (FA) retains the antifouling property and shows recognition abilities toward FBP.	Folic Acid	21-31	folate receptor alpha	Homo sapiens	109-112
31769301-5	2020	In neuroectoderm cells, folic acid insufficiency attenuated association of Msh6 to H3K36me3, and reduced bindings to NTC genes.	Folic Acid	24-34	mutS homolog 6	Homo sapiens	75-79
33373350-5	2020	Folate and vitamin B12 status have been associated with wide DNA methylation, as well as with specific genes related to neurological functions, embryonic development, energy metabolism, growth, and leptin.	Folic Acid	0-6	leptin	Homo sapiens	198-204
31515157-8	2020	Folate analysis of gene-disrupted yeast strains complemented with either Km67-type genes or K7-type genes revealed that the Km67-type HMT1 gene was related to high folate accumulation not only in laboratory yeast but also in sake yeast.	Folic Acid	0-6	protein-arginine omega-N methyltransferase HMT1	Saccharomyces cerevisiae S288C	134-138
31515157-8	2020	Folate analysis of gene-disrupted yeast strains complemented with either Km67-type genes or K7-type genes revealed that the Km67-type HMT1 gene was related to high folate accumulation not only in laboratory yeast but also in sake yeast.	Folic Acid	164-170	protein-arginine omega-N methyltransferase HMT1	Saccharomyces cerevisiae S288C	134-138
31515157-10	2020	Our results and previous reports suggested that the methyltransferase activity of Km67-Hmt1p was higher than that of K7-Hmt1p, leading to enhanced production and high accumulation of folates in Km67 yeast.	Folic Acid	183-190	protein-arginine omega-N methyltransferase HMT1	Saccharomyces cerevisiae S288C	87-92
31754833-1	2020	PURPOSE: The enzymes gamma-glutamyl hydrolase (GGH) and folylpolyglutamate synthetase (FPGS) regulate intracellular folate concentrations needed for cell proliferation, DNA synthesis, and repair.	Folic Acid	116-122	gamma-glutamyl hydrolase	Homo sapiens	21-45
31754833-1	2020	PURPOSE: The enzymes gamma-glutamyl hydrolase (GGH) and folylpolyglutamate synthetase (FPGS) regulate intracellular folate concentrations needed for cell proliferation, DNA synthesis, and repair.	Folic Acid	116-122	gamma-glutamyl hydrolase	Homo sapiens	47-50
31754833-1	2020	PURPOSE: The enzymes gamma-glutamyl hydrolase (GGH) and folylpolyglutamate synthetase (FPGS) regulate intracellular folate concentrations needed for cell proliferation, DNA synthesis, and repair.	Folic Acid	116-122	folylpolyglutamate synthase	Homo sapiens	56-85
31754833-1	2020	PURPOSE: The enzymes gamma-glutamyl hydrolase (GGH) and folylpolyglutamate synthetase (FPGS) regulate intracellular folate concentrations needed for cell proliferation, DNA synthesis, and repair.	Folic Acid	116-122	folylpolyglutamate synthase	Homo sapiens	87-91
31713293-1	2020	OBJECTIVE: To assess the association between polymorphic variants from SHMT1 and MTHFS genes, involved in the cytoplasmic futile folate cycle, and the risk of nonsyndromic cleft lip with or without cleft palate (NSCL/P) in the Chilean population.	Folic Acid	129-135	serine hydroxymethyltransferase 1	Homo sapiens	71-76
31713293-5	2020	CONCLUSIONS: Owing to the rs1979277 A allele, which reduces the cytoplasmic SHMT activity and has a higher frequency in controls than in NSCL/P cases, we hypothesized that a low enzyme activity may increase the cytoplasmic concentration of folates and, therefore, explain the protective role against OFCs.	Folic Acid	240-247	serine hydroxymethyltransferase 1	Homo sapiens	76-80
32999198-10	2020	However, long-term exposure to valproic acid (VPA) affected the expression of folate carriers (FOLR1, SLC46A1).	Folic Acid	78-84	folate receptor alpha	Homo sapiens	95-100
32999198-10	2020	However, long-term exposure to valproic acid (VPA) affected the expression of folate carriers (FOLR1, SLC46A1).	Folic Acid	78-84	solute carrier family 46 member 1	Homo sapiens	102-109
31873125-4	2019	Methotrexate (MTX) and pemetrexed (PTX) are two examples of antifolates that have cured many patients over the years but target different enzymes from the folate cycle (mainly dihydrofolate reductase and thymidylate synthase, respectively).	Folic Acid	64-70	thymidylate synthetase	Homo sapiens	204-224
31796042-1	2019	BACKGROUND: Folate receptor-beta (FR-beta) is a cell surface receptor that is significantly upregulated on activated macrophages during inflammation and provides a potential target for folate-based therapeutic and diagnostic agents.	Folic Acid	185-191	folate receptor beta	Rattus norvegicus	12-32
31648623-5	2019	We present and discuss data regarding the molecular basis of folate and adenosine pathways, the most obvious MTX targets, to explain possible causes of therapy failure.	Folic Acid	61-67	metaxin 1	Homo sapiens	109-112
31739835-1	2019	Gamma-Glutamyl hydrolase (GGH) plays an important role in the disposition of anti-folate analogs.	Folic Acid	82-88	gamma-glutamyl hydrolase	Homo sapiens	0-24
31739835-1	2019	Gamma-Glutamyl hydrolase (GGH) plays an important role in the disposition of anti-folate analogs.	Folic Acid	82-88	gamma-glutamyl hydrolase	Homo sapiens	26-29
31624245-4	2019	Moreover, we found that MYCN mediated the folate cycle via MTHFD2, which contributed one-carbon unit to enhance purine synthesis, and further regulated nucleotide production by PAICS in response to cancer progression.	Folic Acid	42-48	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	24-28
31596135-5	2019	Five sites within FAM198A (p = 0.047, 0.050, 0.039, 0.026 and 0.043, respectively) had a reduced methylation in male newborns whose mother had preconception folic acid supplementation.	Folic Acid	157-167	golgi associated kinase 1A	Homo sapiens	18-25
31029341-0	2019	Folate-PEG/Hyd-curcumin/C18-g-PSI micelles for site specific delivery of curcumin to colon cancer cells via Wnt/beta-catenin signaling pathway.	Folic Acid	0-6	catenin beta 1	Homo sapiens	112-124
30916789-3	2019	Known defects of folate transport are deficiency of the proton coupled folate transporter, associated with systemic as well as cerebral folate deficiency, and deficiency of the folate receptor alpha, leading to an isolated cerebral folate deficiency associated with intractable seizures, developmental delay and/or regression, progressive ataxia and choreoathetoid movement disorders.	Folic Acid	17-23	solute carrier family 46 member 1	Homo sapiens	56-89
30916789-3	2019	Known defects of folate transport are deficiency of the proton coupled folate transporter, associated with systemic as well as cerebral folate deficiency, and deficiency of the folate receptor alpha, leading to an isolated cerebral folate deficiency associated with intractable seizures, developmental delay and/or regression, progressive ataxia and choreoathetoid movement disorders.	Folic Acid	17-23	folate receptor alpha	Homo sapiens	177-198
31185958-9	2019	Finally, several metabolic pathways known to be reprogrammed in cancer cells are detected as prognostic pathways including glutamate metabolism in SHH subgroup, pentose phosphate pathway and TCA cycle in Group 3, and folate-mediated one carbon-metabolism in Group 4.	Folic Acid	217-223	sonic hedgehog signaling molecule	Homo sapiens	147-150
31123778-0	2019	Rapid SERS-based recognition of cell secretome on the folic acid-functionalized gold gratings.	Folic Acid	54-64	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	6-10
31123778-2	2019	In this study, the SERS on a surface plasmon polariton-supported gold grating functionalized with folic acid was used to demonstrate an unpretentious recognition of melanoma-associated fibroblasts.	Folic Acid	98-108	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	19-23
31123778-4	2019	The homogeneous distribution of plasmon energy along the grating surface was proved to provide excellent SERS signal reproducibility, while, to increase the affinity of (bio)molecules to SERS substrate, folic acid molecules were covalently grafted to the gold gratings.	Folic Acid	203-213	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	187-191
30920123-0	2019	DNA Hypomethylation of GR Promoters is Associated with GR Activation and BDNF/AKT/ERK1/2-Induced Hippocampal Neurogenesis in Mice Derived From Folic-Acid-Supplemented Dams.	Folic Acid	143-153	brain derived neurotrophic factor	Mus musculus	73-77
30867454-1	2019	In folate-mediated one-carbon metabolism (FOCM), 5-formyltetrahydrofolate (5fTHF), a one-carbon substituted tetrahydrofolate (THF) vitamer, acts as an intracellular storage form of folate and as an inhibitor of the folate-dependent enzymes phosphoribosylaminoimidazolecarboxamide formyltransferase (AICARFT) and serine hydroxymethyltransferase (SHMT).	Folic Acid	3-9	serine hydroxymethyltransferase 1	Homo sapiens	312-343
30867454-1	2019	In folate-mediated one-carbon metabolism (FOCM), 5-formyltetrahydrofolate (5fTHF), a one-carbon substituted tetrahydrofolate (THF) vitamer, acts as an intracellular storage form of folate and as an inhibitor of the folate-dependent enzymes phosphoribosylaminoimidazolecarboxamide formyltransferase (AICARFT) and serine hydroxymethyltransferase (SHMT).	Folic Acid	3-9	serine hydroxymethyltransferase 1	Homo sapiens	345-349
30937266-3	2019	Here, a matrix metalloprotease 2 responsive liposome (PEG-FA-Lip) composed of cleavable PEG chains covering the folate (FA)-modified liposome is developed to deliver ICD inducer doxorubicin.	Folic Acid	112-118	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	61-64
32476787-9	2020	The restoration of PPARalpha by folic acid was blocked after transfection with SIRT1 siRNA in the Huh7 cell line.	Folic Acid	32-42	peroxisome proliferator activated receptor alpha	Homo sapiens	19-28
32476787-11	2020	CONCLUSION: Folic acid improves hepatic lipid metabolism by upregulating PPARalpha levels via a SIRT1-dependent mechanism and restores hepatic one-carbon metabolism and diversity of gut microbiota, thereby attenuating HFD-induced NASH in rats.	Folic Acid	12-22	peroxisome proliferator activated receptor alpha	Rattus norvegicus	73-82
32405339-7	2020	Our targeted metabolomics analysis showed distinct metabolomics profiles between IDC and adjacent tissue, where IDC displayed a comparative enrichment of metabolites involved in one-carbon metabolism (serine, glycine, threonine, and methionine) and a predicted increase in the activity of pathways that receive and donate carbon units (i.e., folate, methionine, and homocysteine).	Folic Acid	342-348	lamin A/C	Homo sapiens	112-115
32421530-2	2020	In preterm newborns, we previously showed a lower placental mRNA expression of FOLR1 along with higher folate and lower vitamin B12 cord blood levels.	Folic Acid	103-109	folate receptor alpha	Homo sapiens	79-84
32421530-3	2020	Thereby we aimed to explore FOLR1 methylation in placentas of preterm newborns and hypothesized an increased FOLR1 methylation associated with cord blood folates and vitamin B12 concentrations.	Folic Acid	154-161	folate receptor alpha	Homo sapiens	28-33
32421530-3	2020	Thereby we aimed to explore FOLR1 methylation in placentas of preterm newborns and hypothesized an increased FOLR1 methylation associated with cord blood folates and vitamin B12 concentrations.	Folic Acid	154-161	folate receptor alpha	Homo sapiens	109-114
32421530-7	2020	Preterm newborns presented higher folate and lower vitB12 concentrations in cord blood which correlated with increased placental FOLR1 methylation.	Folic Acid	34-40	folate receptor alpha	Homo sapiens	129-134
32421530-8	2020	DISCUSSION: In preterm newborns, placental FOLR1 expression is regulated by epigenetic mechanisms and presumably by maternal concentrations of folate and vitamin B12.	Folic Acid	143-149	folate receptor alpha	Homo sapiens	43-48
32150984-6	2020	The impact of AA on the folate-mediated one-carbon cycle further manifested itself as an increase in the levels of methionine, whose formation from homocysteine is 5-methyl-THF dependent, and an increase in thymidine, whose formation from deoxyuridine monophosphate (dUMP) is dependent on 5,10-methylene-THF.	Folic Acid	24-30	thin fur	Mus musculus	173-176
32150984-6	2020	The impact of AA on the folate-mediated one-carbon cycle further manifested itself as an increase in the levels of methionine, whose formation from homocysteine is 5-methyl-THF dependent, and an increase in thymidine, whose formation from deoxyuridine monophosphate (dUMP) is dependent on 5,10-methylene-THF.	Folic Acid	24-30	thin fur	Mus musculus	304-307
31994802-10	2020	The transcriptomic analysis revealed that folic acid treatment regulated many key metabolic-related genes (DGAT2, ALOX5, LAP3, GPAT3, GGH, ALDOA, TKT) and pathways (glycolysis, folate biosynthesis, glutathione metabolism, etc.)	Folic Acid	42-52	transketolase	Bos taurus	146-149
31926453-2	2020	Placental transfer of folate is mediated by folate receptor alpha (FR-alpha), proton coupled folate transporter (PCFT), and reduced folate carrier (RFC).	Folic Acid	22-28	folate receptor alpha	Homo sapiens	44-65
31926453-2	2020	Placental transfer of folate is mediated by folate receptor alpha (FR-alpha), proton coupled folate transporter (PCFT), and reduced folate carrier (RFC).	Folic Acid	22-28	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	67-75
31926453-2	2020	Placental transfer of folate is mediated by folate receptor alpha (FR-alpha), proton coupled folate transporter (PCFT), and reduced folate carrier (RFC).	Folic Acid	22-28	solute carrier family 46 member 1	Homo sapiens	78-111
31926453-2	2020	Placental transfer of folate is mediated by folate receptor alpha (FR-alpha), proton coupled folate transporter (PCFT), and reduced folate carrier (RFC).	Folic Acid	22-28	solute carrier family 46 member 1	Homo sapiens	113-117
31926453-2	2020	Placental transfer of folate is mediated by folate receptor alpha (FR-alpha), proton coupled folate transporter (PCFT), and reduced folate carrier (RFC).	Folic Acid	44-50	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	67-75
31721048-0	2020	Folic Acid Protects Rat Cerebellum Against Oxidative Damage Caused by Homocysteine: the Expression of Bcl-2, Bax, and Caspase-3 Apoptotic Genes.	Folic Acid	0-10	BCL2 associated X, apoptosis regulator	Rattus norvegicus	109-112
31721048-11	2020	Folic acid significantly reduced MDA level, protein carbonyl content, Bax, the caspase-3 mRNA, and protein expression levels in the cerebellum of Hcy-treated group.	Folic Acid	0-10	BCL2 associated X, apoptosis regulator	Rattus norvegicus	70-73
32121219-7	2020	Significant associations between MC1R-rs1805007 and serum folate levels (p = 0.020), and IRF4-rs12203592 and homocysteine levels (p = 0.026) occurred but did not remain significant following corrections with confounders.	Folic Acid	58-64	melanocortin 1 receptor	Homo sapiens	33-37
32452003-3	2020	Here, we describe the characterization of Schistosoma mansoni DHFR (SmDHFR) using isothermal titration calorimetry for the enzymatic activity and thermodynamic determination, also the folate analogs inhibition.	Folic Acid	184-190	dihydrofolate reductase	Schistosoma mansoni	62-66
31920364-3	2019	The aim of the study was to investigate the effect of folate metabolizing genes (MTHFR and DHFR) polymorphisms on different parameters of complete blood count in patients who were treated with carbamazepine and valproic acid.	Folic Acid	54-60	dihydrofolate reductase	Homo sapiens	91-95
31792273-1	2019	Human proton-coupled folate transporter (hPCFT/SLC46A1) has recently been found to be inhibited by myricetin by a sustained mechanism, raising a concern that the inhibition might lead to malabsorption of folates in the intestine, where hPCFT works for their epithelial uptake.	Folic Acid	204-211	solute carrier family 46 member 1	Homo sapiens	6-39
31792273-1	2019	Human proton-coupled folate transporter (hPCFT/SLC46A1) has recently been found to be inhibited by myricetin by a sustained mechanism, raising a concern that the inhibition might lead to malabsorption of folates in the intestine, where hPCFT works for their epithelial uptake.	Folic Acid	204-211	solute carrier family 46 member 1	Homo sapiens	41-46
31792273-1	2019	Human proton-coupled folate transporter (hPCFT/SLC46A1) has recently been found to be inhibited by myricetin by a sustained mechanism, raising a concern that the inhibition might lead to malabsorption of folates in the intestine, where hPCFT works for their epithelial uptake.	Folic Acid	204-211	solute carrier family 46 member 1	Homo sapiens	47-54
31585510-3	2019	Folypolyglutamate synthetase (FPGS) is known to play a crucial role in the maintenance of intracellular folate levels.	Folic Acid	104-110	folylpolyglutamate synthase	Homo sapiens	0-28
31585510-3	2019	Folypolyglutamate synthetase (FPGS) is known to play a crucial role in the maintenance of intracellular folate levels.	Folic Acid	104-110	folylpolyglutamate synthase	Homo sapiens	30-34
31452255-3	2019	The goal of this study was to determine whether folate is involved in GnAQ methylation and its effect on GnRH secretion.	Folic Acid	48-54	Progonadoliberin-1	Ovis aries	105-109
30670450-0	2019	Folic acid modifies the shape of epithelial cells during morphogenesis via a Folr1 and MLCK dependent mechanism.	Folic Acid	0-10	folate receptor 1 (adult)	Mus musculus	77-82
30670450-5	2019	Utilizing an epithelial cell culture model of apical constriction, it was observed that treatment with exogenous folic acid, as well as co-expression of the folic acid receptor Folr1, can rescue the function of the Rho-kinase binding deficient mutant of Shroom3 in vitro It was also determined that the rescuing ability of folic acid is RhoA and Rho-kinase independent but myosin light chain kinase (MLCK) and Src-kinase dependent.	Folic Acid	157-167	folate receptor 1 (adult)	Mus musculus	177-182
33405856-0	2019	Folic-Acid-Adorned PEGylated Graphene Oxide Interferes with the Cell Migration of Triple Negative Breast Cancer Cell Line, MDAMB-231 by Targeting miR-21/PTEN Axis through NFkappaB.	Folic Acid	0-10	phosphatase and tensin homolog	Gallus gallus	153-157
31078441-12	2019	CONCLUSION: Folic acid ameliorated the adverse effects of homocysteine in the cirrhotic rats, which may be related to down-regulation of the VEGF-NO signaling pathway.	Folic Acid	12-22	vascular endothelial growth factor A	Rattus norvegicus	141-145
30420205-2	2019	A specific transporter protein is required to transport folate from blood to CSF.	Folic Acid	56-62	colony stimulating factor 2	Homo sapiens	77-80
1435744-1	1992	Previous studies have documented the metabolism of a broad range of folate antimetabolites to polyglutamate derivatives by the enzyme folylpoly-gamma-glutamate synthetase (FPGS).	Folic Acid	68-74	folylpolyglutamate synthase	Homo sapiens	134-170
29603098-10	2019	Searching for correlation between DNAmeth of the studied genes with demographic characteristics and baseline biochemical parameters of the studied population, we observed a correlation between IGF2 methylation and folate (r = 0.44, p = 0.003).	Folic Acid	214-220	insulin like growth factor 2	Homo sapiens	193-197
1435744-1	1992	Previous studies have documented the metabolism of a broad range of folate antimetabolites to polyglutamate derivatives by the enzyme folylpoly-gamma-glutamate synthetase (FPGS).	Folic Acid	68-74	folylpolyglutamate synthase	Homo sapiens	172-176
1435744-10	1992	The levels of FPGS found in these transformed stem cells would help to explain the sensitivity of many acute lymphoblastic leukemias to folate antimetabolites.	Folic Acid	136-142	folylpolyglutamate synthase	Homo sapiens	14-18
30500180-5	2018	On the other hand, a detailed comparison of their catalytic and regulatory properties is missing, although this aspect seems to be considerably important, considering that SHMT1 and SHMT2 reside in different cellular compartments, where they play distinct roles in folate metabolism.	Folic Acid	265-271	serine hydroxymethyltransferase 1	Homo sapiens	172-177
1565186-0	1992	Ribosomal protein S6 kinase is activated after folic acid injury and epidermal growth factor administration but not after unilateral nephrectomy in the rat kidney.	Folic Acid	47-57	ribosomal protein S6 kinase B1	Rattus norvegicus	0-27
30572970-2	2019	Genetic disturbances in folate metabolism such as Thymidylate synthase may increase risk for conotruncal heart defects.	Folic Acid	24-30	thymidylate synthetase	Homo sapiens	50-70
1565186-1	1992	Following loss of functional renal mass induced by a single parenteral injection of folic acid, the increased proliferation of tubular epithelium to replace injured and necrotic cells was associated with S6 kinase activation and enhanced phosphorylation of this ribosomal protein in vitro, EGF administered 1.5 h after folic acid promoted the phosphorylation of S6 protein and accelerated the regenerative repair process.	Folic Acid	84-94	ribosomal protein S6 kinase B1	Rattus norvegicus	204-213
29953918-2	2018	Some loci and genes that are associated with folate levels had been detected by genome-wide association studies (GWAS), such as rs1801133 in MTHFR and rs1979277 in SHMT1.	Folic Acid	45-51	serine hydroxymethyltransferase 1	Homo sapiens	164-169
1907850-1	1991	Arginine-70 of human dihydrofolate reductase (hDHFR) is a highly conserved residue which X-ray crystallographic data have shown to interact with the alpha-carboxylate of the terminal L-glutamate moiety of either folic acid or methotrexate (MTX).	Folic Acid	212-222	dihydrofolate reductase	Homo sapiens	21-44
30063111-9	2018	CONCLUSION: The expression of PCFT in placentas from BD-complicated pregnancies is increased, possibly as an adaptive response to increase the folate flux at the maternal-fetal interface.	Folic Acid	143-149	solute carrier family 46 member 1	Homo sapiens	30-34
1907850-1	1991	Arginine-70 of human dihydrofolate reductase (hDHFR) is a highly conserved residue which X-ray crystallographic data have shown to interact with the alpha-carboxylate of the terminal L-glutamate moiety of either folic acid or methotrexate (MTX).	Folic Acid	212-222	dihydrofolate reductase	Homo sapiens	46-51
1889478-3	1991	Folate-deficient cells exhibit a two-fold increase in thymidine kinase and thymidylate synthase activities.	Folic Acid	0-6	thymidylate synthetase	Homo sapiens	75-95
2007575-8	1991	Decreased polyglutamylation was attributable to folylpolyglutamate synthetase (FPGS) activity in R30dm extracts which was 1, 2, and less than or equal to 10% of CCRF-CEM extracts with the substrates MTX, aminopterin, and naturally occurring folates, respectively.	Folic Acid	241-248	folylpolyglutamate synthase	Homo sapiens	48-77
2007575-8	1991	Decreased polyglutamylation was attributable to folylpolyglutamate synthetase (FPGS) activity in R30dm extracts which was 1, 2, and less than or equal to 10% of CCRF-CEM extracts with the substrates MTX, aminopterin, and naturally occurring folates, respectively.	Folic Acid	241-248	folylpolyglutamate synthase	Homo sapiens	79-83
2260989-9	1990	With exposure to concentrations of leucovorin capable of rescue, the individual folate pool levels were up to twelve times greater than those found in untreated cells, consistent with competition for catalytic activity at folate-dependent enzymes in addition to dihydrofolate reductase.	Folic Acid	80-86	dihydrofolate reductase	Homo sapiens	262-285
2265419-1	1990	Folate deficient murine B16 melanoma cells adhered more rapidly and in higher percentages to plastic plates or dishes coated with laminin or fibronectin than folate replete cells.	Folic Acid	0-6	fibronectin 1	Mus musculus	141-152
2253202-0	1990	Multiple membrane transport systems for the uptake of folate-based thymidylate synthase inhibitors.	Folic Acid	54-60	thymidylate synthetase	Homo sapiens	67-87
2253202-5	1990	CEM-FBP cells that have an elevated amount of FBP and do not have a functional reduced folate carrier were 640- and 61-fold more sensitive to CB3717 and ICI-198,583, respectively, compared to control CEM cells expressing the reduced folate/MTX carrier.	Folic Acid	233-239	folate receptor alpha	Homo sapiens	4-7
2253202-6	1990	This high sensitivity was related to a high affinity of the FBP for CB3717 and ICI-198,583 (Kd 2-3 nM), which is only 3-fold lower than for folic acid (Kd 1 nM) but significantly higher than for MTX (Kd 100 nM).	Folic Acid	140-150	folate receptor alpha	Homo sapiens	60-63
2253202-8	1990	These results indicate that multiple folate transport systems may be involved in the uptake of folate-based thymidylate synthase inhibitors.	Folic Acid	37-43	thymidylate synthetase	Homo sapiens	108-128
2253202-8	1990	These results indicate that multiple folate transport systems may be involved in the uptake of folate-based thymidylate synthase inhibitors.	Folic Acid	95-101	thymidylate synthetase	Homo sapiens	108-128
2248959-1	1990	The 2.3-A crystal structure of recombinant human dihydrofolate reductase (EC 1.5.1.3, DHFR) has been solved as a binary complex with folate (a poor substrate at neutral pH) and also as a binary complex with an inhibitor, 5-deazafolate.	Folic Acid	56-62	dihydrofolate reductase	Homo sapiens	86-90
2168155-7	1990	NaHCO3 also activated FPGS activity when folic acid, dihydrofolic acid and tetrahydrofolic acid were substrates.	Folic Acid	41-51	folylpolyglutamate synthase	Homo sapiens	22-26
2168155-10	1990	These results suggest that FPGS activity with folates and classical antifolates may be activated at physiological concentrations of NaHCO3.	Folic Acid	46-53	folylpolyglutamate synthase	Homo sapiens	27-31
33809325-10	2021	Furthermore, we confirmed that the TS 1100T>C polymorphism was synergistic with low folic acid levels (AOR = 6.749, P < 0.0001).	Folic Acid	84-94	thymidylate synthetase	Homo sapiens	35-37
29427035-10	2018	In conclusion, Lactobacillus and folic acid in a mixture with cadmium acted beneficially to an organism, increasing the cadmium excretion in feces, and consequently increasing beta-catenin and BDNF in brain tissue and StAR and 17-beta HSD in testis and improving their functions.	Folic Acid	33-43	brain derived neurotrophic factor	Mus musculus	193-197
29427035-10	2018	In conclusion, Lactobacillus and folic acid in a mixture with cadmium acted beneficially to an organism, increasing the cadmium excretion in feces, and consequently increasing beta-catenin and BDNF in brain tissue and StAR and 17-beta HSD in testis and improving their functions.	Folic Acid	33-43	steroidogenic acute regulatory protein	Mus musculus	218-222
28841122-5	2018	Pituitary adenomas are known to overexpress folate receptor alpha (FRalpha), and it was hypothesized that OTL38, a folate analog conjugated to a near-infrared (NIR) fluorescent dye, could provide real-time intraoperative visual contrast of the tumor versus the surrounding nonneoplastic tissues.	Folic Acid	44-50	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	67-74
29732722-10	2018	Eight more candidate genes (Abcc3, Gsr, Gclc, Mthfd1, Gart, Bche, Slc25a32, and Slc44a2) were identified by examining the DEGs of those genes involved in the extended folate metabolic pathway between FA-responsive and FA-resistant mutants.	Folic Acid	167-173	phosphoribosylglycinamide formyltransferase	Mus musculus	54-58
30006522-4	2018	The results show that the proposed FeN2 stabilizes by a break up of molecule N2 into a novel planar N4 unit (P63/mcm, &gt;228 GPa) while FeN4 stabilizes by a infinite 1D linear nitrogen chains N  (P-1, &gt;50 GPa; Cmmm, &gt;250 GPa).	Folic Acid	100-102	tumor protein p63	Homo sapiens	109-116
29661558-1	2018	INTRODUCTION: Cerebral folate deficiency (CFD) syndromes are defined as neuro-psychiatric conditions with low CSF folate and attributed to different causes such as autoantibodies against the folate receptor-alpha (FR) protein that can block folate transport across the choroid plexus, FOLR1 gene mutations or mitochondrial disorders.	Folic Acid	23-29	folate receptor alpha	Homo sapiens	191-212
29661558-1	2018	INTRODUCTION: Cerebral folate deficiency (CFD) syndromes are defined as neuro-psychiatric conditions with low CSF folate and attributed to different causes such as autoantibodies against the folate receptor-alpha (FR) protein that can block folate transport across the choroid plexus, FOLR1 gene mutations or mitochondrial disorders.	Folic Acid	23-29	folate receptor alpha	Homo sapiens	285-290
29629275-4	2018	This study identified the effect of human cluster of differentiation 36 (CD36) overexpression on the progression of folic acid-induced AKI.	Folic Acid	116-126	CD36 molecule	Homo sapiens	42-71
29326243-2	2018	Studies of PCFT-mediated transport, to date, have focused exclusively on the influx of folates and antifolates.	Folic Acid	87-94	solute carrier family 46 member 1	Homo sapiens	11-15
29326243-4	2018	An HeLa-derived cell line was employed, in which folate-specific transport was mediated exclusively by PCFT.	Folic Acid	49-55	solute carrier family 46 member 1	Homo sapiens	103-107
29474406-10	2018	Irrespective of cancer status, several SNPs were found to be associated with altered serum folate concentrations, including the D919G SNP in methionine synthase (MTR), the L474F SNP in serine hydroxymethyl transferase 1 (SHMT1) and the V175M SNP in phosphatidyl ethanolamine methyltransferase (PEMT).	Folic Acid	91-97	serine hydroxymethyltransferase 1	Homo sapiens	185-219
29474406-10	2018	Irrespective of cancer status, several SNPs were found to be associated with altered serum folate concentrations, including the D919G SNP in methionine synthase (MTR), the L474F SNP in serine hydroxymethyl transferase 1 (SHMT1) and the V175M SNP in phosphatidyl ethanolamine methyltransferase (PEMT).	Folic Acid	91-97	serine hydroxymethyltransferase 1	Homo sapiens	221-226
29171692-1	2018	Dihydropteroate synthase (DHPS) is an enzyme of the folate biosynthesis pathway, which catalyzes the formation of 7,8-dihydropteroate (DHPt) from 6-hydroxymethyl-7,8-dihydropterin pyrophosphate (DHPPP) and para-aminobenzoic acid (pABA).	Folic Acid	52-58	Dihydropteroate synthase	Escherichia coli	0-24
29171692-1	2018	Dihydropteroate synthase (DHPS) is an enzyme of the folate biosynthesis pathway, which catalyzes the formation of 7,8-dihydropteroate (DHPt) from 6-hydroxymethyl-7,8-dihydropterin pyrophosphate (DHPPP) and para-aminobenzoic acid (pABA).	Folic Acid	52-58	Dihydropteroate synthase	Escherichia coli	26-30
30449179-0	2018	Development and characterization of folic acid-functionalized apoferritin as a delivery vehicle for epirubicin against MCF-7 breast cancer cells.	Folic Acid	36-46	ferritin heavy chain 1	Homo sapiens	62-73
29109127-4	2018	The regulatory locus also expresses two functional RNAs, LINC00925-RNA and MIR9-3, which are coexpressed with POLG The MIR9-3 targets include NR2E1, a transcription factor maintaining neural stem cells in undifferentiated state, and MTHFD2, the regulatory enzyme of mitochondrial folate cycle, linking POLG expression to stem cell differentiation and folate metabolism.	Folic Acid	351-357	DNA polymerase gamma, catalytic subunit	Homo sapiens	110-114
29109127-4	2018	The regulatory locus also expresses two functional RNAs, LINC00925-RNA and MIR9-3, which are coexpressed with POLG The MIR9-3 targets include NR2E1, a transcription factor maintaining neural stem cells in undifferentiated state, and MTHFD2, the regulatory enzyme of mitochondrial folate cycle, linking POLG expression to stem cell differentiation and folate metabolism.	Folic Acid	351-357	microRNA 9-3	Homo sapiens	119-125
30378389-0	2018	The folic acid metabolism gene mel-32/Shmt is required for normal cell cycle lengths in Caenorhabditis elegans.	Folic Acid	4-14	serine hydroxymethyltransferase 1	Homo sapiens	38-42
30378389-5	2018	mel-32 is an essential folic acid metabolism gene in C. elegans and a homolog to the mammalian enzyme serine hydroxymethyltransferase (Shmt).	Folic Acid	23-33	serine hydroxymethyltransferase 1	Homo sapiens	135-139
29865064-7	2018	The incremental AbetaPP phosphorylation at Thr668 mediated by severe genetic-or diet-induced impairment of the folate cycle correlates with enhanced accumulation of demethylated protein phosphatase 2A (PP2A), and activation of glycogen synthase kinase-3beta (GSK-3beta).	Folic Acid	111-117	amyloid beta (A4) precursor protein	Mus musculus	16-23
29865064-8	2018	Lastly, we show that severe disturbances in folate metabolism can also affect AbetaPP expression levels in a brain region specific manner.	Folic Acid	44-50	amyloid beta (A4) precursor protein	Mus musculus	78-85
29865064-10	2018	Deregulation of AbetaPP provides a novel mechanism by which common human MTHFR polymorphisms may interact with dietary folate deficiency to alter neuronal homeostasis and increase the risk for sporadic AD.	Folic Acid	119-125	amyloid beta (A4) precursor protein	Mus musculus	16-23
31452255-8	2019	The GnRH expression level in the 40 mg/mL folate group was significantly higher than in the other three groups ( P < .05).	Folic Acid	42-48	Progonadoliberin-1	Ovis aries	4-8
31452255-9	2019	These results demonstrate that the appropriate folate concentration promoted GANQ promoter methylation, which in turn affected GnRH secretion.	Folic Acid	47-53	Progonadoliberin-1	Ovis aries	127-131
31601260-0	2019	Dietary intakes and biomarker patterns of folate, vitamin B6, and vitamin B12 can be associated with cognitive impairment by hypermethylation of redox-related genes NUDT15 and TXNRD1.	Folic Acid	42-48	nudix hydrolase 15	Homo sapiens	165-171
31362825-1	2019	PURPOSE: OTL38 is a folate-indole-cyanine green-like conjugate to folate receptor alpha (FRa).	Folic Acid	20-26	folate receptor alpha	Homo sapiens	66-87
31441204-4	2019	p53/C-rNC/L-FA consists of an acid-activated fusogenic liposomal membrane shell modified with folic acid (L-FA) and a DNA/protein complex core assembled by the p53 DNA, protamine and CytoC-encapsulated redox-responsive nanocapsule (C-rNC).	Folic Acid	94-104	transformation related protein 53, pseudogene	Mus musculus	0-3
31008996-1	2019	BACKGROUND: Folylpolyglutamate synthetase (FPGS) is a crucial enzyme in both cellular folate homeostasis and the intracellular retention of folate analogue drugs like methotrexate (MTX), which is commonly used for the treatment of (pediatric) leukemia and the anchor drug in rheumatoid arthritis (RA) treatment.	Folic Acid	86-92	folylpolyglutamate synthase	Homo sapiens	12-41
31008996-1	2019	BACKGROUND: Folylpolyglutamate synthetase (FPGS) is a crucial enzyme in both cellular folate homeostasis and the intracellular retention of folate analogue drugs like methotrexate (MTX), which is commonly used for the treatment of (pediatric) leukemia and the anchor drug in rheumatoid arthritis (RA) treatment.	Folic Acid	86-92	folylpolyglutamate synthase	Homo sapiens	43-47
31008996-1	2019	BACKGROUND: Folylpolyglutamate synthetase (FPGS) is a crucial enzyme in both cellular folate homeostasis and the intracellular retention of folate analogue drugs like methotrexate (MTX), which is commonly used for the treatment of (pediatric) leukemia and the anchor drug in rheumatoid arthritis (RA) treatment.	Folic Acid	140-146	folylpolyglutamate synthase	Homo sapiens	12-41
31008996-1	2019	BACKGROUND: Folylpolyglutamate synthetase (FPGS) is a crucial enzyme in both cellular folate homeostasis and the intracellular retention of folate analogue drugs like methotrexate (MTX), which is commonly used for the treatment of (pediatric) leukemia and the anchor drug in rheumatoid arthritis (RA) treatment.	Folic Acid	140-146	folylpolyglutamate synthase	Homo sapiens	43-47
31400381-1	2019	Novel bioconjugates (Agm6-M-PEG-FA) for active oligonucleotide (ON) delivery have been developed by conjugating a cationic oligo-guanidyl star-like shaped "head" (Agm6-M) to a polymeric "tail" (PEG) terminating with folic acid (FA) as targeting agent or methoxy group (Agm6-M-PEG-FA and Agm6-M-PEG-OCH3, respectively).	Folic Acid	216-226	CD79b molecule	Homo sapiens	21-25
31570767-6	2019	By knocking down expression of K-Ras using antisense oligonucleotides in a mouse model of chronic folic acid nephropathy we can reduce fibrosis by 50% and prevent the loss of renal function over 3 months.	Folic Acid	98-108	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	31-36
31461931-5	2019	In this study, l-BSO was encapsulated in a folate-targeted generation four polyurea dendrimer (PUREG4-FA2) and its release profile was followed for 24 h at pH 7.4 and 37  C. The protocol uses in situ l-BSO derivatization, by the formation of a catechol-derived orto-quinone, followed by visible detection of the derivative at 503 nm.	Folic Acid	43-49	FA complementation group B	Homo sapiens	95-105
30902310-0	2019	Water-soluble vitamins for controlling starch digestion: Conformational scrambling and inhibition mechanism of human pancreatic alpha-amylase by ascorbic acid and folic acid.	Folic Acid	163-173	amylase alpha 2A	Homo sapiens	117-141
31223065-8	2019	A high tumoral expression of the genes SLC46A1/PCFT, SLC19A1/RFC-1, ABCC3/MRP3, GGH, and MTHFD1L, which are involved in folate transport, polyglutamation, or metabolism, was associated with longer disease-free survival of the patients.	Folic Acid	120-126	solute carrier family 46 member 1	Homo sapiens	39-46
31223065-8	2019	A high tumoral expression of the genes SLC46A1/PCFT, SLC19A1/RFC-1, ABCC3/MRP3, GGH, and MTHFD1L, which are involved in folate transport, polyglutamation, or metabolism, was associated with longer disease-free survival of the patients.	Folic Acid	120-126	solute carrier family 46 member 1	Homo sapiens	47-51
31223065-8	2019	A high tumoral expression of the genes SLC46A1/PCFT, SLC19A1/RFC-1, ABCC3/MRP3, GGH, and MTHFD1L, which are involved in folate transport, polyglutamation, or metabolism, was associated with longer disease-free survival of the patients.	Folic Acid	120-126	gamma-glutamyl hydrolase	Homo sapiens	80-83
31807357-5	2019	The bioaccessibility of folic acid ranged between 56-71 and 35-49% in infant formula samples, between 59-78 and 31-67% in cereal-based baby foods, and between 42-67 and 38-57% in follow-on baby milk at gastric pH 1.5 and pH 4, respectively.	Folic Acid	24-34	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	210-214
31807357-5	2019	The bioaccessibility of folic acid ranged between 56-71 and 35-49% in infant formula samples, between 59-78 and 31-67% in cereal-based baby foods, and between 42-67 and 38-57% in follow-on baby milk at gastric pH 1.5 and pH 4, respectively.	Folic Acid	24-34	prolyl 4-hydroxylase, transmembrane	Homo sapiens	221-225
30858177-1	2019	The proton-coupled folate transporter (PCFT) mediates intestinal absorption of folates and their transport from blood to cerebrospinal fluid across the choroid plexus.	Folic Acid	79-86	solute carrier family 46 member 1	Homo sapiens	39-43
30853412-1	2019	OBJECTIVES: The purpose of this study was to assess the expression of the 3 major folate transporters-folate receptors (FRs), reduced folate carrier (RFC), and proton-coupled folate transporter (PCFT)-in oral squamous cell carcinoma (OSCC).	Folic Acid	82-88	solute carrier family 46 member 1	Homo sapiens	160-193
30853412-1	2019	OBJECTIVES: The purpose of this study was to assess the expression of the 3 major folate transporters-folate receptors (FRs), reduced folate carrier (RFC), and proton-coupled folate transporter (PCFT)-in oral squamous cell carcinoma (OSCC).	Folic Acid	82-88	solute carrier family 46 member 1	Homo sapiens	195-199
30920573-2	2019	Herein, we synthesized biocompatible folic acid (FA)-functionalized DHE-modified TiP (TiP-PAH-DHE-FA) nanoparticles as a drug delivery system that possessed high drug loading capability and enhanced folate-receptor-mediated cellular uptake.	Folic Acid	37-47	TOR signaling pathway regulator	Homo sapiens	81-84
30920573-2	2019	Herein, we synthesized biocompatible folic acid (FA)-functionalized DHE-modified TiP (TiP-PAH-DHE-FA) nanoparticles as a drug delivery system that possessed high drug loading capability and enhanced folate-receptor-mediated cellular uptake.	Folic Acid	37-47	TOR signaling pathway regulator	Homo sapiens	86-100
30954083-2	2019	To analyze the methylation profile of the ADRB3 gene and correlate it with lipid profile, lipid intake, and oxidative stress based on malondialdehyde (MDA) and total antioxidant capacity (TAC), homocysteine and folic acid levels, nutritional status, lifestyle, and socioeconomic variables in an adult population.	Folic Acid	211-221	adrenoceptor beta 3	Homo sapiens	42-47
30954083-7	2019	CONCLUSIONS: These results suggest that epigenetic changes in the ADRB3 gene locus may explain the development of obesity and non-communicable diseases associated with trans-fat intake, altered lipid profile, and elevated folic acid.	Folic Acid	222-232	adrenoceptor beta 3	Homo sapiens	66-71
30940212-12	2019	Evidence from DMR and FL analyses indicated that dietary folate and alcohol intake may be associated with genomic regions with tumor suppressor activity such as the GSDMD and HOXA5 genes.	Folic Acid	57-63	homeobox A5	Homo sapiens	175-180
32397266-11	2020	In a mouse model of folic acid-induced AKI to CKD transition, treatment with lactoferrin recovered renal function and further suppressed renal fibrosis through the inhibition of apoptosis and the induction of autophagy.	Folic Acid	20-30	lactotransferrin	Mus musculus	77-88
31345146-10	2019	RESULTS: Compared with control group, the folic acid plus vitamin B 12 group had significantly greater improvements in serum folate, homocysteine, vitamin B 12 and IL-6, TNF-alpha, MCP-1.	Folic Acid	42-52	C-C motif chemokine ligand 2	Homo sapiens	181-186
24993594-1	2014	INTRODUCTION: Folate receptor-alpha regulates cellular uptake of folates and antifolates (eg, pemetrexed) and is frequently expressed in pulmonary adenocarcinoma.	Folic Acid	65-72	folate receptor alpha	Homo sapiens	14-35
31266025-8	2019	In animal studies, hyperhomocysteinemia (hHcy) induced by folate-free diet was shown to induce NLRP3 inflammasome formation and activation in glomeruli, which was also mimicked by UTP and inhibited by NSC23766 to a comparable level seen in Nlrp3 gene knockout mice.	Folic Acid	58-64	NLR family, pyrin domain containing 3	Mus musculus	95-100
31266025-8	2019	In animal studies, hyperhomocysteinemia (hHcy) induced by folate-free diet was shown to induce NLRP3 inflammasome formation and activation in glomeruli, which was also mimicked by UTP and inhibited by NSC23766 to a comparable level seen in Nlrp3 gene knockout mice.	Folic Acid	58-64	NLR family, pyrin domain containing 3	Mus musculus	240-245
34464807-6	2022	In addition, some heterotrophic bacteria cooperating with AnAOB (Comamonas and Simplicispira) were found more active in R1 than that of R2 due to the higher relative abundance of functional genes related to folic acid metabolic (Dihydrofolate synthase and Dihydrofolate reductase).	Folic Acid	207-217	dihydrofolate reductase	Homo sapiens	256-279
29616859-3	2018	FR-alpha and FR-beta are present on many cancers with little expression in normal tissues; leading to the testing of at least six folate-targeted drugs in human clinical trials for various cancers.	Folic Acid	130-136	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	0-8
29616859-3	2018	FR-alpha and FR-beta are present on many cancers with little expression in normal tissues; leading to the testing of at least six folate-targeted drugs in human clinical trials for various cancers.	Folic Acid	130-136	folate receptor beta	Homo sapiens	13-20
34755744-4	2021	By loading DiR into the hydrophobic domain of folic acid-icodextrin-polycaprolactone (FA-ICO-PCL, FIP) and cisplatin-icodextrin-polycaprolactone (Pt-ICO-PCL, PtIP) co-assembly, the resultant DiR@(PtIP + FIP) (DPtFIP) NPs had a diameter of around 70 nm and showed excellent tumor targeting ability and negligible side effects.	Folic Acid	46-56	PAX interacting protein 1	Homo sapiens	196-200
29708443-1	2018	OBJECTIVE: Previous studies have not used family-based methods to evaluate maternal-paternal genetic effects of the folate metabolizing enzyme, dihydro folate reductase (DHFR) essential during embryogenesis.	Folic Acid	116-122	dihydrofolate reductase	Homo sapiens	144-168
29708443-1	2018	OBJECTIVE: Previous studies have not used family-based methods to evaluate maternal-paternal genetic effects of the folate metabolizing enzyme, dihydro folate reductase (DHFR) essential during embryogenesis.	Folic Acid	116-122	dihydrofolate reductase	Homo sapiens	170-174
29656957-7	2018	PGA alone was sufficient to induce expression of TNF-alpha, IL-6, MCP-1, and MIP1-alpha, whereas MDP alone did not under the same conditions.	Folic Acid	0-3	chemokine (C-C motif) ligand 3	Mus musculus	77-87
34358645-0	2021	Ceramide Synthase 6 mediates sex-specific metabolic response to dietary folic acid in mice.	Folic Acid	72-82	ceramide synthase 6	Mus musculus	0-19
34562187-0	2021	Folic acid attenuated learning and memory impairment via inhibition of oxidative damage and acetylcholinesterase activity in hypothyroid rats.	Folic Acid	0-10	acetylcholinesterase	Rattus norvegicus	92-112
27941566-14	2018	Folate targeted therapies may be most useful in patients with chemotherapy resistant disease based on high levels of FRA expression in these tumors.	Folic Acid	0-6	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	117-120
34825630-1	2021	Resistance to folate antagonists is caused by mutations in the dihydrofolate reductase (DHFR) genes.	Folic Acid	14-20	dihydrofolate reductase	Homo sapiens	63-86
34825630-1	2021	Resistance to folate antagonists is caused by mutations in the dihydrofolate reductase (DHFR) genes.	Folic Acid	14-20	dihydrofolate reductase	Homo sapiens	88-92
30165906-3	2018	We hypothesised that genetic factors linked to folate metabolism may play a role in BWS predisposition via effects on methylation maintenance at KCNQ1OT1 TSS-DMR.	Folic Acid	47-53	KCNQ1 opposite strand/antisense transcript 1	Homo sapiens	145-153
34293696-6	2021	Gene expression of folate carriers (Folr1, Slc19a1, Slc46a1) and metabolizing enzymes (Cth, Mtr, Mtrr, Mthfr, Dhfr) was assessed in the placenta on gestational day (GD) 13 or GD20.	Folic Acid	19-25	folate receptor alpha	Rattus norvegicus	36-41
30113208-2	2018	Our recent genetic analyses in spontaneously hypertensive rats (SHR) revealed mutated Folr1 (folate receptor 1) on chromosome 1 as a quantitative trait gene associated with reduced folate levels, hypercysteinemia and metabolic disturbances.	Folic Acid	93-99	folate receptor alpha	Rattus norvegicus	86-91
30113208-5	2018	Next we analyzed the effects of the Folh1 alleles on folate and sulfur amino acid levels and consecutively on glucose and lipid metabolism using SHR-1 congenic sublines harboring either Folr1 BN and Folh1 SHR alleles or Folr1 SHR and Folh1 BN alleles.	Folic Acid	53-59	folate hydrolase 1	Rattus norvegicus	36-41
34215121-5	2021	Layer-by-layer (LbL) self-assembly was used to modify indium tin oxide (ITO) electrodes with alternating layers of polyallylamine hydrochloride (PAH) and folic acid (FA), which binds to overexpressed folate receptors alpha (FRalpha) in tumor cells.	Folic Acid	154-164	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	224-231
30113208-7	2018	These results strongly suggest that, in addition to Folr1, the Folh1 gene also plays an important role in folate and sulfur amino acid levels and affects glucose and lipid metabolism in the rat.	Folic Acid	106-112	folate hydrolase 1	Rattus norvegicus	63-68
34243040-4	2021	In the current study, we showed that the percentages of NKT+ cells and NKT+-IL-4+ cells were notably increased in folic acid (FA) and obstructive nephropathy.	Folic Acid	114-124	interleukin 4	Mus musculus	76-80
30120883-3	2018	This study aims to evaluate the association between genetic defects in folate metabolism pathway genes, mainly: Folate hydrolase 1 (FOLH1), Dihydrofolate reductase (DHFR) and Methylenetetrahydrofolate reductase (MTHFR) and neural tube defects from eastern India.	Folic Acid	71-77	dihydrofolate reductase	Homo sapiens	140-163
30120883-3	2018	This study aims to evaluate the association between genetic defects in folate metabolism pathway genes, mainly: Folate hydrolase 1 (FOLH1), Dihydrofolate reductase (DHFR) and Methylenetetrahydrofolate reductase (MTHFR) and neural tube defects from eastern India.	Folic Acid	71-77	dihydrofolate reductase	Homo sapiens	165-169
34103333-3	2021	The present study determined whether delivery of PHD2 siRNA using a siRNA carrier, folic acid (FA)-decorated polyamidoamine dendrimer generation 5 (G5-FA), would mainly target kidneys and protect against renal ischemia/reperfusion injury (I/R).	Folic Acid	83-93	egl-9 family hypoxia-inducible factor 1	Mus musculus	49-53
29777263-13	2018	Hepatic Ppara gene expression was upregulated in female offspring only (1.51-fold, p   0.05) and was restored in the female offspring by folate treatment (p   0.05).	Folic Acid	137-143	peroxisome proliferator activated receptor alpha	Rattus norvegicus	8-13
34277456-3	2021	Our study aimed to synthesize a targeted folate receptor-alpha near-infrared (NIR) fluorescent agent, folic acid-zwitterionic NIR fluorophore (ZW-FA), and explore the feasibility for screening of endometrial cancer and precancerous change.	Folic Acid	102-112	folate receptor alpha	Homo sapiens	41-62
34094663-5	2021	Second, folic acid (FA) conjugated PLGA nanoparticles (FA-SS-PLGA) targeting tumor cells were prepared to mediate ENO1mAb entry into cells and its anti-tumor effects were investigated in vitro.	Folic Acid	8-18	enolase 1	Homo sapiens	114-118
30036071-2	2018	Our recent genetic analyses in spontaneously hypertensive rats (SHR) revealed a mutated Folr1 (folate receptor 1) as the quantitative trait gene associated with diminished renal Folr1 expression, lower plasma folate levels, hypercysteinemia, hyperhomocysteinemia and metabolic disturbances.	Folic Acid	95-101	folate receptor alpha	Rattus norvegicus	88-93
30036071-2	2018	Our recent genetic analyses in spontaneously hypertensive rats (SHR) revealed a mutated Folr1 (folate receptor 1) as the quantitative trait gene associated with diminished renal Folr1 expression, lower plasma folate levels, hypercysteinemia, hyperhomocysteinemia and metabolic disturbances.	Folic Acid	95-101	folate receptor alpha	Rattus norvegicus	178-183
34093861-10	2021	Conclusions: Based on the results, we proposed a potential pathway for HGF or TGF-beta1-induced EMT of HCC cells: HGF or TGF-beta1 treatment of HCC cells can increase the expression of glycosyltransferase FUT8 to up-regulate the core-fucosylation of N-glycans on glycoproteins including the FOLR1; core-fucosylation on FOLR1 can then enhance the folate uptake capacity to finally promote the EMT progress of HCC cells.	Folic Acid	346-352	folate receptor alpha	Homo sapiens	319-324
35322363-0	2022	Folic acid alleviates lead acetate-mediated cardiotoxicity by down-regulating the expression levels of Nrf2, HO-1, GRP78, and CHOP proteins.	Folic Acid	0-10	DNA-damage inducible transcript 3	Rattus norvegicus	126-130
29360079-1	2018	Methotrexate is an antimetabolite analog to folic acid that competitively inhibits the enzyme dihydrofolate reductase and thymidylate synthetase, essential for the synthesis of DNA and RNA.	Folic Acid	44-54	thymidylate synthetase	Homo sapiens	122-144
2557328-5	1989	In addition, virtually all of the folate binding sites on the plasma membrane of the intact cells were released as soluble, functional FBP following treatment with PI-PLC.	Folic Acid	34-40	folate receptor beta	Homo sapiens	135-138
2804108-3	1989	An interaction of DTSSP with the reduced folate/MTX is substantiated by findings that: (a) like MTX transport itself, the concentration of DTSSP required for half-maximal inhibition of [3H]methotrexate transport varied substantially with the anionic composition of the external medium.	Folic Acid	41-47	metaxin 1	Homo sapiens	96-99
29435118-8	2018	Thus, while folate-targeted imaging of lung cancer patients might accurately reflect the expression of FR-alpha on lung cancer cells, imaging of pancreatic cancer patients could mislead a physician into treating a nonresponding patient.	Folic Acid	12-18	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	103-111
29435118-9	2018	Overall, these data suggest that an independent analysis of both FR-alpha and FR-beta should be obtained to predict the potential efficacy of a folate-targeted drug.	Folic Acid	144-150	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	65-73
29435118-9	2018	Overall, these data suggest that an independent analysis of both FR-alpha and FR-beta should be obtained to predict the potential efficacy of a folate-targeted drug.	Folic Acid	144-150	folate receptor beta	Homo sapiens	78-85
2566606-4	1989	In this study, we demonstrate markedly elevated expression of the protooncogenes c-fos, c-myc, c-Ki-ras, and c-Ha-ras following acute renal injury induced by a single large parenteral dose of folic acid.	Folic Acid	192-202	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	88-93
29046732-0	2017	Effect of a diet containing folate and hazelnut oil capsule on the methylation level of the ADRB3 gene, lipid profile and oxidative stress in overweight or obese women.	Folic Acid	28-34	adrenoceptor beta 3	Homo sapiens	92-97
2496552-2	1989	These Cbl-deficient cells gradually ceased to multiply when the medium contained 5-CH3THF, although cell growth was resumed following the addition of CNCbl, OHCbl or folic acid.	Folic Acid	166-176	Casitas B-lineage lymphoma	Mus musculus	6-9
28884569-2	2017	Herein, we developed a drug delivery platform of carbon dots which were connected to a stem-loop molecular beacon loaded with doxorubicin and polyethylene glycol modified folic acid.	Folic Acid	171-181	ubiquitin like 5	Homo sapiens	107-113
2561247-8	1989	Comparison of the amino acid sequences of peptides of the placental receptor obtained by digestion with S. aureus V8 protease indicate the presence of two homologous forms of the folate binding protein in placenta; one of these forms appears to have an identical sequence to the soluble and membrane associated folate binding proteins in human epidermoid carcinoma (KB) cells, which in turn share the primary structure of the soluble and membrane associated folate binders in human milk in the regions that have been sequenced.	Folic Acid	311-317	folate receptor alpha	Homo sapiens	179-201
28551461-5	2017	This manuscript focuses on the interaction between self-assembled nanoparticles decorated with a folic acid (FA) ligand and FRalpha.	Folic Acid	97-107	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	124-131
28658642-4	2017	When the nanomicelles were tested in folate-receptor overexpressing ovarian and cervical cancer cells they exhibited high anticancer activity causing significant cell population to undergo apoptosis due to upregulation of tumor suppressor phosphatase and tensin homolog (PTEN) and inhibition of nuclear factor kappa-B (NFkappaB), which further confirmed the targeting ability and anticancer potentials of folate-targeted formulations.	Folic Acid	37-43	phosphatase and tensin homolog	Homo sapiens	271-275
27646260-4	2017	FRalpha Ab can trigger inflammation as well as block folate transport to the fetus and to the developing brain to produce the functional deficits.	Folic Acid	53-59	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	0-7
28675599-2	2017	Subsequent modification with the targeting reagent folic acid (FA) led to generation of the CUR/NaGdF4 -DOX/AFn-FA conjugate for cancer treatment.	Folic Acid	51-61	ferritin heavy chain 1	Homo sapiens	108-111
28105727-9	2017	Quantitative PCR demonstrated that key genes in this network (zinc finger E-box binding homeobox 2, v-myc myelocytomatosis viral oncogene homolog (avian), and cyclin-dependent kinase 6) were reduced (p &lt; 0.05) in placentas with low maternal folate status.	Folic Acid	244-250	zinc finger E-box binding homeobox 2	Homo sapiens	62-98
28105727-9	2017	Quantitative PCR demonstrated that key genes in this network (zinc finger E-box binding homeobox 2, v-myc myelocytomatosis viral oncogene homolog (avian), and cyclin-dependent kinase 6) were reduced (p &lt; 0.05) in placentas with low maternal folate status.	Folic Acid	244-250	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	100-145
28794626-0	2017	Folic acid-functionalized polyethylenimine superparamagnetic iron oxide nanoparticles as theranostic agents for magnetic resonance imaging and PD-L1 siRNA delivery for gastric cancer.	Folic Acid	0-10	CD274 molecule	Homo sapiens	143-148
28794626-3	2017	We developed folic acid (FA)- and disulfide (SS)-polyethylene glycol (PEG)-conjugated polyethylenimine (PEI) complexed with superparamagnetic iron oxide Fe3O4 nanoparticles (SPIONs) as a siRNA-delivery system for PD-L1 knockdown.	Folic Acid	13-23	CD274 molecule	Homo sapiens	213-218
28748002-0	2017	High levels of circulating folate concentrations are associated with DNA methylation of tumor suppressor and repair genes p16, MLH1, and MGMT in elderly Chileans.	Folic Acid	27-33	mutL homolog 1	Homo sapiens	127-131
28748002-4	2017	RESULTS: We found that serum folate and to a lesser extent, vitamin B12 concentrations, were significantly correlated with DNA methylation of p16, MLH1, and MGMT, but not with LINE-1.	Folic Acid	29-35	mutL homolog 1	Homo sapiens	147-151
2807044-4	1989	During pyridoxine and folate treatment, antithrombin III activity rapidly returned to normal; factor VII increased and beta-thromboglobulin decreased.	Folic Acid	22-28	serpin family C member 1	Homo sapiens	40-56
29737910-7	2018	Therefore, folate (FA) is being evaluated as an active targeting moiety for FR-alpha+ ovarian cancer.	Folic Acid	11-17	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	76-84
2476708-0	1989	Mode of c-myc gene regulation in folic acid-induced kidney regeneration.	Folic Acid	33-43	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	8-13
29486262-1	2018	In our previous study, we demonstrated that folate-appended methyl-beta-cyclodextrin (FA-M-beta-CyD) was a promising antitumor agent for the treatment of folate receptor-alpha (FR-alpha)-expressing tumors.	Folic Acid	44-50	folate receptor alpha	Homo sapiens	154-175
29486262-1	2018	In our previous study, we demonstrated that folate-appended methyl-beta-cyclodextrin (FA-M-beta-CyD) was a promising antitumor agent for the treatment of folate receptor-alpha (FR-alpha)-expressing tumors.	Folic Acid	44-50	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	177-185
2476708-2	1989	The c-myc gene is activated in kidney tubule cells which are induced to proliferate as a consequence of folic acid-induced renal injury in vivo.	Folic Acid	104-114	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	4-9
29799386-1	2018	Dihydrofolate reductase (DHFR) and 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) transformylase/IMP cyclohydrolase (PurH) play key roles in maintaining folate pools in cells, and are targets of antimicrobial and anticancer drugs.	Folic Acid	7-13	Dihydrofolate reductase	Escherichia coli	25-29
2906805-2	1988	COOH-18O-labeled folate, methotrexate, and dihydropteroate, in addition to [17O]-glutamate, were synthesized and used as substrates for folylpolyglutamate synthetase (FPGS) isolated from Escherichia coli, hog liver, and rat liver and for dihydrofolate synthetase (DHFS) isolated from E. coli.	Folic Acid	17-23	folylpolyglutamate synthase	Homo sapiens	167-171
29799386-9	2018	Thus, our studies reveal that both DHFR and PurH could utilise 10-CHO-DHF for folate homeostasis in E. coli.	Folic Acid	78-84	Dihydrofolate reductase	Escherichia coli	35-39
3190739-6	1988	Because of the lack of appreciable interaction with other folate-dependent enzymes, structures incorporating the 2-amino-4-oxo-5,8-dideazapteroate nucleus may thus lead to selective inhibition of FPGS.	Folic Acid	58-64	folylpolyglutamate synthase	Homo sapiens	196-200
29922516-0	2018	A novel thymidylate synthase from the Vibrionales, Alteromonadales, Aeromonadales, and Pasteurellales (VAAP) clade with altered nucleotide and folate binding sites.	Folic Acid	143-149	thymidylate synthetase	Homo sapiens	8-28
3385729-9	1988	These effects demonstrate that the alpha-carboxyl group of folate analogues is involved in binding to the active site of FPGS, and that an alpha-carboxyl group should be retained as part of the structure of FPGS inhibitors.	Folic Acid	59-65	folylpolyglutamyl synthetase	Mus musculus	121-125
29866117-0	2018	Decrease of the DNA methylation levels of the ADRB3 gene in leukocytes is related with serum folate in eutrophic adults.	Folic Acid	93-99	adrenoceptor beta 3	Homo sapiens	46-51
29866117-7	2018	From the multiple regression analysis in the group of eutrophic adults, it was observed a negative relationship between methylation levels of the ADRB3 gene with serum levels of folic acid.	Folic Acid	178-188	adrenoceptor beta 3	Homo sapiens	146-151
29866117-9	2018	CONCLUSIONS: A negative relationship was demonstrated between methylation levels of the ADRB3 gene in eutrophic adults individuals with serum levels of folic acid, as well as with the independent gender of BMI, however, was not observed relation with lipid profile, oxidative stress and variables of food intake.	Folic Acid	152-162	adrenoceptor beta 3	Homo sapiens	88-93
29394471-1	2018	Folate deficiency can affect fetal and neonatal brain development Considering the reported association of Folate receptor alpha (FRalpha) autoantibodies (Abs) with autism and developmental disorders, we sought to confirm this in families of 82 children with ASD, 53 unaffected siblings, 65 fathers, and 70 mothers, along with 52 unrelated normal controls.	Folic Acid	0-6	folate receptor alpha	Homo sapiens	106-127
29394471-1	2018	Folate deficiency can affect fetal and neonatal brain development Considering the reported association of Folate receptor alpha (FRalpha) autoantibodies (Abs) with autism and developmental disorders, we sought to confirm this in families of 82 children with ASD, 53 unaffected siblings, 65 fathers, and 70 mothers, along with 52 unrelated normal controls.	Folic Acid	0-6	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	129-136
29502397-4	2018	In this study, we established for the first time a high-performance PSA Glycomics Assay (PGA), allowing differentiation of alpha2,6- and alpha2,3-sialylated isomers, the latter one being suggested to be a hallmark of aggressive types of cancer.	Folic Acid	89-92	kallikrein related peptidase 3	Homo sapiens	68-71
29502397-9	2018	In summary, the first PGA successfully established in this study allows an in-depth relative quantitation of PSA glycoforms from urine.	Folic Acid	22-25	kallikrein related peptidase 3	Homo sapiens	109-112
29223574-8	2018	These results suggested that the increase in folic acid uptake after exposure to VPA can be attributed to the induction of FRalpha and PCFT expression.	Folic Acid	45-55	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	123-130
29223574-8	2018	These results suggested that the increase in folic acid uptake after exposure to VPA can be attributed to the induction of FRalpha and PCFT expression.	Folic Acid	45-55	solute carrier family 46 member 1	Homo sapiens	135-139
29167151-1	2018	The proton-coupled folate transporter (PCFT-SLC46A1) is required for folate transport across the apical membrane of the small intestine and across the choroid plexus.	Folic Acid	19-25	solute carrier family 46 member 1	Homo sapiens	39-43
29167151-1	2018	The proton-coupled folate transporter (PCFT-SLC46A1) is required for folate transport across the apical membrane of the small intestine and across the choroid plexus.	Folic Acid	19-25	solute carrier family 46 member 1	Homo sapiens	44-51
29167151-4	2018	Pemetrexed, a high-affinity substrate for PCFT, decreased or abolished biotinylation of seven of these residues consistent with their location in or near the folate binding pocket.	Folic Acid	158-164	solute carrier family 46 member 1	Homo sapiens	42-46
29358613-0	2018	Key apoptotic genes APAF1 and CASP9 implicated in recurrent folate-resistant neural tube defects.	Folic Acid	60-66	caspase 9	Homo sapiens	30-35
29341861-4	2018	Our analyses revealed that differentiation and the mRNA expression of the gene myogenin in C2C12 cell were enhanced by folic acid; however, the overall methylation percentage in myogenin promoter between different treatment groups was not significantly different ( P &gt; 0.05).	Folic Acid	119-129	myogenin	Mus musculus	79-87
29341861-8	2018	Together, these analyses suggest that folate deficiency and supplementation can influence the differentiation, genome-wide DNA methylation level and the expression of myogenesis-related genes including myogenin in the C2C12 cell line.	Folic Acid	38-44	myogenin	Mus musculus	202-210
28639476-6	2018	The expressions of DNMT1 and GAP43, which were significantly upregulated in the IUGR group compared with the normal controls, were decreased with the folic acid intervention.	Folic Acid	150-160	DNA methyltransferase 1	Rattus norvegicus	19-24
29447234-0	2018	Folic acid derived-P5779 mimetics regulate DAMP-mediated inflammation through disruption of HMGB1:TLR4:MD-2 axes.	Folic Acid	0-10	toll like receptor 4	Homo sapiens	98-102
29447234-4	2018	Molecular dynamic (MD) simulation studies demonstrate that folic acid mimics the binding of P5779 at the TLR4 and MD-2 intersection.	Folic Acid	59-69	toll like receptor 4	Homo sapiens	105-109
29162511-4	2018	METHODS: We investigated if major polymorphisms of folate-related genes, namely MTHFR c.677C>T, MTR c.2756A>G, MTRR c.66A>G and TYMS TSER (a 28-bp tandem repeat in the 5" promoter enhancer region of TYMS) increase the risk of pathological changes of the thymus in AChR+ MG patients.	Folic Acid	51-57	thymidylate synthetase	Homo sapiens	128-132
29162511-4	2018	METHODS: We investigated if major polymorphisms of folate-related genes, namely MTHFR c.677C>T, MTR c.2756A>G, MTRR c.66A>G and TYMS TSER (a 28-bp tandem repeat in the 5" promoter enhancer region of TYMS) increase the risk of pathological changes of the thymus in AChR+ MG patients.	Folic Acid	51-57	thymidylate synthetase	Homo sapiens	199-203
28185129-6	2018	Furthermore, folic acid in the presence of glutamate insult in hippocampal slices maintained for an additional period of 6 h in fresh culture medium without glutamate and/or folic acid induced phosphorylation of GSK-3beta and beta-catenin expression.	Folic Acid	13-23	catenin beta 1	Rattus norvegicus	226-238
28185129-8	2018	In conclusion, the results of this study show that the protective effect of folic acid against glutamate-induced excitotoxicity may involve the modulation of PI3K/GSK-3beta/beta-catenin pathway and iNOS inhibition.	Folic Acid	76-86	catenin beta 1	Rattus norvegicus	173-185
29155362-3	2018	We developed a folic acid (FA)-conjugated polyamidoamine dendrimer (Den)-based nanoparticle (NP) system for co-delivery of siRNA against HuR mRNA (HuR siRNA) and cis-diamine platinum (CDDP) to folate receptor-alpha (FRA) -overexpressing H1299 lung cancer cells.	Folic Acid	15-25	ELAV like RNA binding protein 1	Homo sapiens	137-140
29155362-3	2018	We developed a folic acid (FA)-conjugated polyamidoamine dendrimer (Den)-based nanoparticle (NP) system for co-delivery of siRNA against HuR mRNA (HuR siRNA) and cis-diamine platinum (CDDP) to folate receptor-alpha (FRA) -overexpressing H1299 lung cancer cells.	Folic Acid	15-25	ELAV like RNA binding protein 1	Homo sapiens	147-150
29155362-3	2018	We developed a folic acid (FA)-conjugated polyamidoamine dendrimer (Den)-based nanoparticle (NP) system for co-delivery of siRNA against HuR mRNA (HuR siRNA) and cis-diamine platinum (CDDP) to folate receptor-alpha (FRA) -overexpressing H1299 lung cancer cells.	Folic Acid	15-25	folate receptor alpha	Homo sapiens	193-214
29540272-0	2018	Association of low dietary folate intake with lower CAMKK2 gene methylation, adiposity, and insulin resistance in obese subjects.	Folic Acid	27-33	calcium/calmodulin dependent protein kinase kinase 2	Homo sapiens	52-58
29540272-3	2018	This study hypothesized associations between low folate intakes and lower methylation levels of the CAMKK2 gene, with the presence of metabolic alterations in subjects with obesity.	Folic Acid	49-55	calcium/calmodulin dependent protein kinase kinase 2	Homo sapiens	100-106
29540272-8	2018	A total of 51 cytosine-phosphate-guanine sites were associated with folate intake (false discovery rate values &lt; 0.0001), including one located in the 5" untranslated region of the CAMKK2 gene (Illumina ID, cg16942632), which was selected and separately analyzed.	Folic Acid	68-74	calcium/calmodulin dependent protein kinase kinase 2	Homo sapiens	184-190
29540272-10	2018	Of note, folate deficiency was related to lower CAMKK2 methylation.	Folic Acid	9-15	calcium/calmodulin dependent protein kinase kinase 2	Homo sapiens	48-54
29540272-13	2018	In summary, this study suggests associations between low folate intakes, lower CAMKK2 gene methylation, and insulin resistance in obese individuals.	Folic Acid	57-63	calcium/calmodulin dependent protein kinase kinase 2	Homo sapiens	79-85
28988145-1	2018	The role of Alpha folate receptors (FRalpha) in folate metabolism and cancer development has been extensively studied.	Folic Acid	18-24	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	36-43
29127457-2	2018	PCFT was discovered in 2006 and was identified as the principal folate transporter involved in the intestinal absorption of dietary folates.	Folic Acid	132-139	solute carrier family 46 member 1	Homo sapiens	0-4
29379364-3	2018	S-adenosyl-l-methionine (SAM) is an important intermediate of folic acid pathway and acts as methyl donor and substrate for DNA (cytosine-5)-methyltransferase 3B (DNMT3B - EC 2.1.1.37) de novo methylation processes during embryogenesis.	Folic Acid	62-72	DNA methyltransferase 3 beta	Homo sapiens	124-161
29379364-3	2018	S-adenosyl-l-methionine (SAM) is an important intermediate of folic acid pathway and acts as methyl donor and substrate for DNA (cytosine-5)-methyltransferase 3B (DNMT3B - EC 2.1.1.37) de novo methylation processes during embryogenesis.	Folic Acid	62-72	DNA methyltransferase 3 beta	Homo sapiens	163-169
30592864-0	2018	[Assessment of the sufficiency of Moscow population with folic acid, depending on the combined effect of polymorphism of MTHFR and FTO genes].	Folic Acid	57-67	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	131-134
30592864-1	2018	The results of assessing the sufficiency of folic acid of the residents of the Moscow region have been presented depending on rs1801133 MTHFR gene polymorphism and rs9939609 FTO gene polymorphism.	Folic Acid	44-54	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	174-177
28833104-0	2017	Low folate metabolic stress reprograms DNA methylation-activated sonic hedgehog signaling to mediate cancer stem cell-like signatures and invasive tumour stage-specific malignancy of human colorectal cancers.	Folic Acid	4-10	sonic hedgehog signaling molecule	Homo sapiens	65-79
28833104-2	2017	Folate analysis on the 99 paired human CRC tissues localized LFMS to the deep invasive T3/T4 staged tumours with hypo-methylated sonic hedgehog (Shh) promoter region and amplified expressions of Shh ligand and Gli1 effector, which coincided with deregulated expressions of the epithelial-mesenchymal transition (EMT) mediators.	Folic Acid	0-6	sonic hedgehog signaling molecule	Homo sapiens	195-198
28833104-3	2017	Colonic folate levels of CRC were inversely correlated with pluripotent expressions of the SOX2, NANOG and OCT4 markers (p &lt; 0.05).	Folic Acid	8-14	POU class 5 homeobox 1	Homo sapiens	107-111
29070520-0	2017	Folic acid inhibits nasopharyngeal cancer cell proliferation and invasion via activation of FRalpha/ERK1/2/TSLC1 pathway.	Folic Acid	0-10	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	92-99
28778973-0	2017	Impact of folic acid intake during pregnancy on genomic imprinting of IGF2/H19 and 1-carbon metabolism.	Folic Acid	10-20	insulin like growth factor 2	Homo sapiens	70-74
28778973-0	2017	Impact of folic acid intake during pregnancy on genomic imprinting of IGF2/H19 and 1-carbon metabolism.	Folic Acid	10-20	H19 imprinted maternally expressed transcript	Homo sapiens	75-84
28778973-3	2017	We investigated the association between folic acid supplementation during pregnancy and loss of imprinting (LOI) of IGF2 and H19 genes in placentas and cord blood of 90 mother-child dyads in association with the methylenetetrahydrofolate reductase (MTHFR) genotype.	Folic Acid	40-50	insulin like growth factor 2	Homo sapiens	116-120
28778973-3	2017	We investigated the association between folic acid supplementation during pregnancy and loss of imprinting (LOI) of IGF2 and H19 genes in placentas and cord blood of 90 mother-child dyads in association with the methylenetetrahydrofolate reductase (MTHFR) genotype.	Folic Acid	40-50	H19 imprinted maternally expressed transcript	Homo sapiens	125-128
28778973-10	2017	Impact of folic acid intake during pregnancy on genomic imprinting of IGF2/H19 and 1-carbon metabolism.	Folic Acid	10-20	insulin like growth factor 2	Homo sapiens	70-74
28778973-10	2017	Impact of folic acid intake during pregnancy on genomic imprinting of IGF2/H19 and 1-carbon metabolism.	Folic Acid	10-20	H19 imprinted maternally expressed transcript	Homo sapiens	75-84
28631291-7	2017	Among the findings, there was a significant association between folic acid concentration and hsa-let-7 g methylation level in NTD cases.	Folic Acid	64-74	microRNA let-7g	Homo sapiens	93-104
28631291-9	2017	Overexpression of hsa-let-7 g, along with its target genes, disturbed the migration and proliferation of SK-N-SH cells, implying that hsa-let-7 g plays important roles in the prevention of NTDs by folic acid.	Folic Acid	197-207	microRNA let-7g	Homo sapiens	18-29
28631291-9	2017	Overexpression of hsa-let-7 g, along with its target genes, disturbed the migration and proliferation of SK-N-SH cells, implying that hsa-let-7 g plays important roles in the prevention of NTDs by folic acid.	Folic Acid	197-207	microRNA let-7g	Homo sapiens	134-145
28631291-10	2017	In summary, our data suggest a relationship between aberrant methylation of hsa-let-7 g and disturbed folate metabolism in NTDs, implying that improvements in nutrition during early pregnancy may prevent such defects, possibly via the donation of methyl groups for miRNAs.	Folic Acid	102-108	microRNA let-7g	Homo sapiens	76-87
29321350-8	2017	The restoration of one-carbon homeostasis by SHMT1 C1420T or increased flux of folate towards remethylation due to TYMS 5"-UTR 28 bp tandem repeat or nonvegetarian diet can lower homocysteine levels.	Folic Acid	79-85	thymidylate synthetase	Homo sapiens	115-119
3385729-9	1988	These effects demonstrate that the alpha-carboxyl group of folate analogues is involved in binding to the active site of FPGS, and that an alpha-carboxyl group should be retained as part of the structure of FPGS inhibitors.	Folic Acid	59-65	folylpolyglutamyl synthetase	Mus musculus	207-211
3377808-5	1988	These results, taken together with previously established structure-activity correlations, imply that a negative charge at the gamma-position of folate analogs may be required for initial binding to FPGS and thus constitutes a prerequisite for activity of potential mechanism-based inhibitors of this enzyme.	Folic Acid	145-151	folylpolyglutamyl synthetase	Mus musculus	199-203
28921898-7	2017	Moreover, the maternal folate supplement decreased BDNF and Grin2b methylation and upregulated their expressions in the brain of offspring, which were associated with decreasing the expression of DNA methyltransferases compared with those dams were treated only HFD in pregnancy.	Folic Acid	23-29	brain derived neurotrophic factor	Mus musculus	51-55
28921898-7	2017	Moreover, the maternal folate supplement decreased BDNF and Grin2b methylation and upregulated their expressions in the brain of offspring, which were associated with decreasing the expression of DNA methyltransferases compared with those dams were treated only HFD in pregnancy.	Folic Acid	23-29	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	60-66
28885847-2	2017	Folate transport in mammalian tissues is mediated by three major folate transport systems, i.e., reduced folate carrier (RFC), proton-coupled folate transporter (PCFT), and folate receptor alpha (FRalpha), known to be regulated by ligand-activated nuclear receptors, such as vitamin D receptor (VDR).	Folic Acid	0-6	solute carrier family 46 member 1	Homo sapiens	127-160
3339615-0	1988	Inhibition of murine thymidylate synthase and human dihydrofolate reductase by 5,8-dideaza analogues of folic acid and aminopterin.	Folic Acid	104-114	dihydrofolate reductase	Homo sapiens	52-75
28885847-2	2017	Folate transport in mammalian tissues is mediated by three major folate transport systems, i.e., reduced folate carrier (RFC), proton-coupled folate transporter (PCFT), and folate receptor alpha (FRalpha), known to be regulated by ligand-activated nuclear receptors, such as vitamin D receptor (VDR).	Folic Acid	0-6	solute carrier family 46 member 1	Homo sapiens	162-166
28885847-2	2017	Folate transport in mammalian tissues is mediated by three major folate transport systems, i.e., reduced folate carrier (RFC), proton-coupled folate transporter (PCFT), and folate receptor alpha (FRalpha), known to be regulated by ligand-activated nuclear receptors, such as vitamin D receptor (VDR).	Folic Acid	0-6	folate receptor alpha	Homo sapiens	173-194
28885847-2	2017	Folate transport in mammalian tissues is mediated by three major folate transport systems, i.e., reduced folate carrier (RFC), proton-coupled folate transporter (PCFT), and folate receptor alpha (FRalpha), known to be regulated by ligand-activated nuclear receptors, such as vitamin D receptor (VDR).	Folic Acid	0-6	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	196-203
28885847-2	2017	Folate transport in mammalian tissues is mediated by three major folate transport systems, i.e., reduced folate carrier (RFC), proton-coupled folate transporter (PCFT), and folate receptor alpha (FRalpha), known to be regulated by ligand-activated nuclear receptors, such as vitamin D receptor (VDR).	Folic Acid	65-71	solute carrier family 46 member 1	Homo sapiens	127-160
28885847-2	2017	Folate transport in mammalian tissues is mediated by three major folate transport systems, i.e., reduced folate carrier (RFC), proton-coupled folate transporter (PCFT), and folate receptor alpha (FRalpha), known to be regulated by ligand-activated nuclear receptors, such as vitamin D receptor (VDR).	Folic Acid	65-71	folate receptor alpha	Homo sapiens	173-194
28885847-2	2017	Folate transport in mammalian tissues is mediated by three major folate transport systems, i.e., reduced folate carrier (RFC), proton-coupled folate transporter (PCFT), and folate receptor alpha (FRalpha), known to be regulated by ligand-activated nuclear receptors, such as vitamin D receptor (VDR).	Folic Acid	65-71	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	196-203
28885847-3	2017	Folate uptake at the choroid plexus, which requires the actions of both FRalpha and PCFT, is critical to cerebral folate delivery.	Folic Acid	0-6	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	72-79
28885847-3	2017	Folate uptake at the choroid plexus, which requires the actions of both FRalpha and PCFT, is critical to cerebral folate delivery.	Folic Acid	0-6	solute carrier family 46 member 1	Homo sapiens	84-88
28885847-3	2017	Folate uptake at the choroid plexus, which requires the actions of both FRalpha and PCFT, is critical to cerebral folate delivery.	Folic Acid	114-120	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	72-79
28885847-3	2017	Folate uptake at the choroid plexus, which requires the actions of both FRalpha and PCFT, is critical to cerebral folate delivery.	Folic Acid	114-120	solute carrier family 46 member 1	Homo sapiens	84-88
2977717-8	1988	This analysis also suggests that folate analogs inhibitory to thymidylate synthase are more compatible than pyrimidine analogs with inhibition of thymidylate synthase as an approach to cancer chemotherapy.	Folic Acid	33-39	thymidylate synthetase	Homo sapiens	62-82
28948692-2	2017	Folate transporters (SLC19A1, SLC46A1, SLC25A32, and FOLH1) and folate receptors (FOLR1, FOLR2, and FOLR3) are suggested to play essential roles in transporting folate from maternal intestinal lumen to the developing embryo.	Folic Acid	64-70	folate receptor alpha	Homo sapiens	82-87
2977717-8	1988	This analysis also suggests that folate analogs inhibitory to thymidylate synthase are more compatible than pyrimidine analogs with inhibition of thymidylate synthase as an approach to cancer chemotherapy.	Folic Acid	33-39	thymidylate synthetase	Homo sapiens	146-166
28948692-2	2017	Folate transporters (SLC19A1, SLC46A1, SLC25A32, and FOLH1) and folate receptors (FOLR1, FOLR2, and FOLR3) are suggested to play essential roles in transporting folate from maternal intestinal lumen to the developing embryo.	Folic Acid	64-70	folate receptor beta	Homo sapiens	89-94
3619447-0	1987	Human liver folylpolyglutamate synthetase: biochemical characterization and interactions with folates and folate antagonists.	Folic Acid	94-101	folylpolyglutamate synthase	Homo sapiens	12-41
28410844-13	2017	CONCLUSION: We found a lower incidence of FOLR1 expression in TNBC compared with other studies; however, these patients may benefit from anti-folate therapy as other targeted therapies are not available.	Folic Acid	142-148	folate receptor alpha	Homo sapiens	42-47
3619447-0	1987	Human liver folylpolyglutamate synthetase: biochemical characterization and interactions with folates and folate antagonists.	Folic Acid	94-100	folylpolyglutamate synthase	Homo sapiens	12-41
3619447-9	1987	In the case of AMT and several reduced folates, inhibition of human liver FPGS was observed at substrate concentrations at or above 50-250 microM.	Folic Acid	39-46	folylpolyglutamate synthase	Homo sapiens	74-78
3517565-0	1986	Tissue folate polyglutamate chain length determination by electrophoresis as thymidylate synthase-fluorodeoxyuridylate ternary complexes.	Folic Acid	7-13	thymidylate synthetase	Homo sapiens	77-97
28826993-6	2017	Developing blastula and tumor cells both require folr1 expression to obtain folate.	Folic Acid	76-82	folate receptor alpha	Homo sapiens	49-54
3838667-0	1985	Inhibition of glycine N-methyltransferase activity by folate derivatives: implications for regulation of methyl group metabolism.	Folic Acid	54-60	glycine N-methyltransferase	Rattus norvegicus	14-41
29110850-8	2017	Expression of FOLR1 in lung cancer cell lines corresponded with the intracellular uptake of folate-porphysomes in vitro.	Folic Acid	92-98	folate receptor alpha	Homo sapiens	14-19
29110850-12	2017	CONCLUSION: Folate-porphysome based PDT shows promise in selectively ablating lung cancer based on FOLR1 expression in these preclinical models.	Folic Acid	12-18	folate receptor alpha	Homo sapiens	99-104
4064054-4	1985	Since FBP may decrease available intracellular folate the present data support clinical findings that chemotherapeutic agents may be more effective for ER negative tumors.	Folic Acid	47-53	folate receptor alpha	Homo sapiens	6-9
28939595-0	2017	Dihydrofolate Reductase/Thymidylate Synthase Fine-Tunes the Folate Status and Controls Redox Homeostasis in Plants.	Folic Acid	60-66	thymidylate synthetase	Homo sapiens	24-44
28939595-3	2017	This work presents a complete study of a plant DHFR-TS (dihydrofolate reductase-thymidylate synthase) gene family that implements the penultimate step in folate biosynthesis.	Folic Acid	63-69	dihydrofolate reductase	Homo sapiens	47-51
28939595-3	2017	This work presents a complete study of a plant DHFR-TS (dihydrofolate reductase-thymidylate synthase) gene family that implements the penultimate step in folate biosynthesis.	Folic Acid	63-69	thymidylate synthetase	Homo sapiens	80-100
28939595-4	2017	We demonstrate that one of the DHFR-TS isoforms (DHFR-TS3) operates as an inhibitor of its two homologs, thus regulating DHFR and TS activities and, as a consequence, folate abundance.	Folic Acid	167-173	dihydrofolate reductase	Homo sapiens	31-35
28939595-4	2017	We demonstrate that one of the DHFR-TS isoforms (DHFR-TS3) operates as an inhibitor of its two homologs, thus regulating DHFR and TS activities and, as a consequence, folate abundance.	Folic Acid	167-173	dihydrofolate reductase	Homo sapiens	49-53
6882460-7	1983	The observation that NADH supports the reduction of folate and dihydrofolate but not MTX binding suggests that natural resistance to MTX could exist if NADH replaces NADPH as the main cofactor for DHFR.	Folic Acid	52-58	dihydrofolate reductase	Homo sapiens	197-201
28939595-4	2017	We demonstrate that one of the DHFR-TS isoforms (DHFR-TS3) operates as an inhibitor of its two homologs, thus regulating DHFR and TS activities and, as a consequence, folate abundance.	Folic Acid	167-173	dihydrofolate reductase	Homo sapiens	49-53
28916296-7	2017	Incubation with excess free folate resulted in a significant decrease in the uptake of targeted nanoparticles in LNCaP and PC3 cells, both of which have been reported to have differing pathways of folate uptake.	Folic Acid	28-34	proprotein convertase subtilisin/kexin type 1	Homo sapiens	123-126
28916296-7	2017	Incubation with excess free folate resulted in a significant decrease in the uptake of targeted nanoparticles in LNCaP and PC3 cells, both of which have been reported to have differing pathways of folate uptake.	Folic Acid	197-203	proprotein convertase subtilisin/kexin type 1	Homo sapiens	123-126
28472749-0	2017	Neutral PEGylated liposomal formulation for efficient folate-mediated delivery of MCL1 siRNA to activated macrophages.	Folic Acid	54-60	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	82-86
28472749-5	2017	In this study, we evaluate the efficiency of folate-targeted liposomes for specific delivery of siRNA to activated macrophages, key effector cells in rheumatoid arthritis (RA) pathology which specifically express folate receptor beta (FRbeta).	Folic Acid	45-51	folate receptor beta	Homo sapiens	213-233
28472749-5	2017	In this study, we evaluate the efficiency of folate-targeted liposomes for specific delivery of siRNA to activated macrophages, key effector cells in rheumatoid arthritis (RA) pathology which specifically express folate receptor beta (FRbeta).	Folic Acid	45-51	folate receptor beta	Homo sapiens	235-241
28638048-2	2017	Here we tested the hypothesis that mTOR functions as a folate sensor in vivo in mice and that maternal folate deficiency inhibits placental mTOR signaling and amino acid transporter activity and causes fetal growth restriction.	Folic Acid	55-61	mechanistic target of rapamycin kinase	Mus musculus	35-39
28638048-2	2017	Here we tested the hypothesis that mTOR functions as a folate sensor in vivo in mice and that maternal folate deficiency inhibits placental mTOR signaling and amino acid transporter activity and causes fetal growth restriction.	Folic Acid	103-109	mechanistic target of rapamycin kinase	Mus musculus	140-144
28638048-7	2017	We have identified a novel specific molecular link between maternal folate availability and fetal growth, involving regulation of placental mTOR signaling by folate, resulting in changes in placental nutrient transport.	Folic Acid	68-74	mechanistic target of rapamycin kinase	Mus musculus	140-144
28638048-7	2017	We have identified a novel specific molecular link between maternal folate availability and fetal growth, involving regulation of placental mTOR signaling by folate, resulting in changes in placental nutrient transport.	Folic Acid	158-164	mechanistic target of rapamycin kinase	Mus musculus	140-144
28638048-8	2017	mTOR folate sensing may have broad biological significance because of the critical role of folate in normal cell function and the wide range of disorders, including cancer, that have been linked to folate availability.	Folic Acid	5-11	mechanistic target of rapamycin kinase	Mus musculus	0-4
28638048-8	2017	mTOR folate sensing may have broad biological significance because of the critical role of folate in normal cell function and the wide range of disorders, including cancer, that have been linked to folate availability.	Folic Acid	91-97	mechanistic target of rapamycin kinase	Mus musculus	0-4
28638048-8	2017	mTOR folate sensing may have broad biological significance because of the critical role of folate in normal cell function and the wide range of disorders, including cancer, that have been linked to folate availability.	Folic Acid	91-97	mechanistic target of rapamycin kinase	Mus musculus	0-4
28043790-1	2017	BACKGROUND: Thymidylate synthase (TYMS), a key rate-limiting enzyme in the folate metabolism, plays essential roles in the development of several malignancies including hepatocellular carcinoma (HCC).	Folic Acid	75-81	thymidylate synthetase	Homo sapiens	12-32
28043790-1	2017	BACKGROUND: Thymidylate synthase (TYMS), a key rate-limiting enzyme in the folate metabolism, plays essential roles in the development of several malignancies including hepatocellular carcinoma (HCC).	Folic Acid	75-81	thymidylate synthetase	Homo sapiens	34-38
28496133-3	2017	Dihydrofolate reductase (DHFR) is a key enzyme to regulate folate metabolism, however folate/DHFR activity in oligodendrocyte development has not been fully understood.	Folic Acid	7-13	dihydrofolate reductase	Homo sapiens	25-29
28496133-3	2017	Dihydrofolate reductase (DHFR) is a key enzyme to regulate folate metabolism, however folate/DHFR activity in oligodendrocyte development has not been fully understood.	Folic Acid	7-13	dihydrofolate reductase	Homo sapiens	93-97
28496133-4	2017	Here we show that folate enhances oligodendrocyte maturation both in vitro and in vivo, which is accompanied with upregulation of oligodendrocyte-specific DHFR expression.	Folic Acid	18-24	dihydrofolate reductase	Homo sapiens	155-159
28496133-5	2017	On the other hand, pharmacological inhibition of DHFR by methotrexate (MTX) causes severe defects in oligodendrocyte survival and differentiation, which could be reversed by folate intake.	Folic Acid	174-180	dihydrofolate reductase	Homo sapiens	49-53
28445960-8	2017	Folate deficiency significantly reduced the expression of ESR1, CAV1, and ELAVL1, which are critical to spermatogenesis.	Folic Acid	0-6	ELAV like RNA binding protein 1	Homo sapiens	74-80
28407838-12	2017	The levels of IGF-1 and IGFBP-3 in the maternal serum, as well as folate content and IGFBP-3 in the fetal brain and liver were significantly lower in the folate deficient group than in the control group (P&lt;0.05).	Folic Acid	154-160	insulin-like growth factor 1	Rattus norvegicus	14-19
28052876-2	2017	Here, we show that PDGFRbeta-positive pericytes isolated from mice subjected to obstructive or folic acid injury secrete C1q.	Folic Acid	95-105	platelet derived growth factor receptor, beta polypeptide	Mus musculus	19-28
28052876-2	2017	Here, we show that PDGFRbeta-positive pericytes isolated from mice subjected to obstructive or folic acid injury secrete C1q.	Folic Acid	95-105	complement component 1, q subcomponent, alpha polypeptide	Mus musculus	121-124
28110184-1	2017	Dendrimers functionalized with folic acid (FA) are drug delivery systems that can selectively target cancer cells with folate receptors (FR-alpha) overexpression.	Folic Acid	31-41	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	137-145
28338744-1	2017	Most species, such as humans, have monofunctional forms of thymidylate synthase (TS) and dihydrofolate reductase (DHFR) that are key folate metabolism enzymes making critical folate components required for DNA synthesis.	Folic Acid	96-102	thymidylate synthetase	Homo sapiens	59-79
28338744-1	2017	Most species, such as humans, have monofunctional forms of thymidylate synthase (TS) and dihydrofolate reductase (DHFR) that are key folate metabolism enzymes making critical folate components required for DNA synthesis.	Folic Acid	96-102	dihydrofolate reductase	Homo sapiens	114-118
28338744-1	2017	Most species, such as humans, have monofunctional forms of thymidylate synthase (TS) and dihydrofolate reductase (DHFR) that are key folate metabolism enzymes making critical folate components required for DNA synthesis.	Folic Acid	133-139	thymidylate synthetase	Homo sapiens	59-79
28338744-1	2017	Most species, such as humans, have monofunctional forms of thymidylate synthase (TS) and dihydrofolate reductase (DHFR) that are key folate metabolism enzymes making critical folate components required for DNA synthesis.	Folic Acid	133-139	dihydrofolate reductase	Homo sapiens	89-112
28338744-1	2017	Most species, such as humans, have monofunctional forms of thymidylate synthase (TS) and dihydrofolate reductase (DHFR) that are key folate metabolism enzymes making critical folate components required for DNA synthesis.	Folic Acid	133-139	dihydrofolate reductase	Homo sapiens	114-118
28155935-0	2017	Folate binding protein: therapeutic natural nanotechnology for folic acid, methotrexate, and leucovorin.	Folic Acid	63-73	folate receptor alpha	Homo sapiens	0-22
28191262-6	2017	RESULTS: Maternal dietary and supplemental intake of methyl-group donors (folate, betaine, folic acid), only in the periconception period, was associated with buccal cell DNA methylation in genes related to growth (IGF2 DMR), metabolism (RXRA), and appetite control (LEP).	Folic Acid	74-80	insulin like growth factor 2	Homo sapiens	215-219
28191262-6	2017	RESULTS: Maternal dietary and supplemental intake of methyl-group donors (folate, betaine, folic acid), only in the periconception period, was associated with buccal cell DNA methylation in genes related to growth (IGF2 DMR), metabolism (RXRA), and appetite control (LEP).	Folic Acid	74-80	leptin	Homo sapiens	267-270
28191262-6	2017	RESULTS: Maternal dietary and supplemental intake of methyl-group donors (folate, betaine, folic acid), only in the periconception period, was associated with buccal cell DNA methylation in genes related to growth (IGF2 DMR), metabolism (RXRA), and appetite control (LEP).	Folic Acid	91-101	insulin like growth factor 2	Homo sapiens	215-219
28191262-6	2017	RESULTS: Maternal dietary and supplemental intake of methyl-group donors (folate, betaine, folic acid), only in the periconception period, was associated with buccal cell DNA methylation in genes related to growth (IGF2 DMR), metabolism (RXRA), and appetite control (LEP).	Folic Acid	91-101	leptin	Homo sapiens	267-270
28191262-7	2017	A negative association was found between maternal folate and folic acid intake before pregnancy and infant LEP (slope = -1.233, 95% CI -2.342; -0.125, p = 0.0298) and IGF2 DMR methylation (slope = -0.706, 95% CI -1.242; -0.107, p = 0.0101), respectively.	Folic Acid	50-56	leptin	Homo sapiens	107-110
28191262-7	2017	A negative association was found between maternal folate and folic acid intake before pregnancy and infant LEP (slope = -1.233, 95% CI -2.342; -0.125, p = 0.0298) and IGF2 DMR methylation (slope = -0.706, 95% CI -1.242; -0.107, p = 0.0101), respectively.	Folic Acid	50-56	insulin like growth factor 2	Homo sapiens	167-171
28191262-7	2017	A negative association was found between maternal folate and folic acid intake before pregnancy and infant LEP (slope = -1.233, 95% CI -2.342; -0.125, p = 0.0298) and IGF2 DMR methylation (slope = -0.706, 95% CI -1.242; -0.107, p = 0.0101), respectively.	Folic Acid	61-71	leptin	Homo sapiens	107-110
29133192-8	2017	The combined supplementation of folic acid, vitamin B12 and omega-3 fatty acids improved placental IL-10 levels and decreased TNF-alpha levels in offspring livers.	Folic Acid	32-42	interleukin 10	Rattus norvegicus	99-104
28374905-12	2017	Folate sensing by mTOR in PHT cells involves both mTOR Complex 1 and 2 and requires the proton-coupled folate transporter (PCFT, SLC46A1).	Folic Acid	0-6	solute carrier family 46 member 1	Homo sapiens	123-127
28374905-12	2017	Folate sensing by mTOR in PHT cells involves both mTOR Complex 1 and 2 and requires the proton-coupled folate transporter (PCFT, SLC46A1).	Folic Acid	0-6	solute carrier family 46 member 1	Homo sapiens	129-136
28374905-13	2017	The involvement of PCFT in mTOR folate sensing is not dependent on its function as a plasma membrane folate transporter.	Folic Acid	32-38	solute carrier family 46 member 1	Homo sapiens	19-23
28374905-16	2017	We have identified a previously unknown molecular link between folate availability and cell function involving PCFT and mTOR signalling.	Folic Acid	63-69	solute carrier family 46 member 1	Homo sapiens	111-115
28569209-1	2017	BACKGROUND: Folate receptor beta (FRbeta) is involved in facilitating cellular uptake of folates and anti-folates (such as methotrexate (MTX)).	Folic Acid	89-96	folate receptor beta	Rattus norvegicus	12-32
28569209-1	2017	BACKGROUND: Folate receptor beta (FRbeta) is involved in facilitating cellular uptake of folates and anti-folates (such as methotrexate (MTX)).	Folic Acid	106-113	folate receptor beta	Rattus norvegicus	12-32
6577780-4	1983	Folylpolyglutamate synthetase, partially purified from mouse liver, was found to accept a variety of folate derivatives as substrates, including pteroic acid and methotrexate; however, the concentration of these substrates that saturated the reaction varied considerably.	Folic Acid	101-107	folylpolyglutamate synthase	Homo sapiens	0-29
28094532-1	2017	Tumor targeting with folic acid radioconjugates has been proposed as a promising strategy for radionuclide therapy of folate receptor alpha (FR)-positive cancer.	Folic Acid	21-31	folate receptor 1 (adult)	Mus musculus	118-139
6577780-6	1983	The cytotoxicity of folylpolyglutamate synthetase inhibitors was predicted to require continued cell division since their effects would be based upon a decreased rate of synthesis of folate cofactors capable of retention by the cell membrane.	Folic Acid	183-189	folylpolyglutamate synthase	Homo sapiens	20-49
28231500-2	2017	Carbon based systems such as graphene oxide (GO), plasmonic nanoparticles such as silver nanoparticles (AgNPs), and the folate analog, methotrexate (MTX), have been separately studied for their potential anticancer effects.	Folic Acid	120-126	metaxin 1	Homo sapiens	149-152
7044835-3	1982	However, with the exception of the reaction catalyzed by thymidylate synthase, explicit oxidoreductions of the H4folate cofactor do not occur in enzyme-catalyzed folate-dependent reactions.	Folic Acid	113-119	thymidylate synthetase	Sus scrofa	57-77
28231500-6	2017	Folic acid analog MTX interacts with folate receptors expressed in MCF-7 cells, improving cellular uptake and subsequent anticancer effects of the system.	Folic Acid	0-10	metaxin 1	Homo sapiens	18-21
28237602-11	2017	In the present study, supplementary folic acid altered energy partitioning in early lactation as suggested by similar milk total solid yield and postpartum energy balance, lower plasma nonesterified fatty acid concentration and body condition score losses, and higher plasma glucose and insulin concentrations for cows receiving folic acid supplement compared with cows that did not.	Folic Acid	36-46	insulin	Bos taurus	287-294
27664775-1	2017	The proton-coupled folate transporter (PCFT-SLC46A1) is the mechanism by which folates are absorbed across the brush-border membrane of the small intestine.	Folic Acid	79-86	solute carrier family 46 member 1	Homo sapiens	39-43
27664775-1	2017	The proton-coupled folate transporter (PCFT-SLC46A1) is the mechanism by which folates are absorbed across the brush-border membrane of the small intestine.	Folic Acid	79-86	solute carrier family 46 member 1	Homo sapiens	44-51
27664775-5	2017	This paper reviews the current understanding of the functional and structural properties and regulation of PCFT, an electrogenic proton symporter, and contrasts PCFT properties with those of the reduced folate carrier (RFC), an organic anion antiporter, that is the major route of folate transport to systemic tissues.	Folic Acid	203-209	solute carrier family 46 member 1	Homo sapiens	107-111
27664775-5	2017	This paper reviews the current understanding of the functional and structural properties and regulation of PCFT, an electrogenic proton symporter, and contrasts PCFT properties with those of the reduced folate carrier (RFC), an organic anion antiporter, that is the major route of folate transport to systemic tissues.	Folic Acid	281-287	solute carrier family 46 member 1	Homo sapiens	107-111
27664775-7	2017	The ways in which PCFT and FRalpha might interact at the level of the choroid plexus such that each is required for folate transport from blood to cerebrospinal fluid are considered along with the different clinical presentations of HFM and CFD.	Folic Acid	116-122	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	27-34
6889511-0	1982	The effect of derivatives of folic acid on the fluorodeoxyuridylate-thymidylate synthetase covalent complex in human colon xenografts.	Folic Acid	29-39	thymidylate synthetase	Homo sapiens	68-90
27883261-0	2017	Prevention of neural tube defects in Lrp2 mutant mouse embryos by folic acid supplementation.	Folic Acid	66-76	low density lipoprotein receptor-related protein 2	Mus musculus	37-41
27883261-8	2017	Importantly, Lrp2null/+ dams had reduced blood folate levels that improved with daily intraperitoneal injections of folate but not dietary supplementation.	Folic Acid	47-53	low density lipoprotein receptor-related protein 2	Mus musculus	13-17
27883261-8	2017	Importantly, Lrp2null/+ dams had reduced blood folate levels that improved with daily intraperitoneal injections of folate but not dietary supplementation.	Folic Acid	116-122	low density lipoprotein receptor-related protein 2	Mus musculus	13-17
27883261-9	2017	On the contrary, iron supplementation had no effect on the penetrance of NTDs in Lrp2 mutant embryos and negated the preventative effect of folic acid supplementation in Lrp2null/null mutants.	Folic Acid	140-150	low density lipoprotein receptor-related protein 2	Mus musculus	170-174
28138029-1	2017	Folate uptake in epithelial ovarian cancer (EOC) involves the reduced folate carrier (RFC) and the proton-coupled folate transporter (PCFT), both facilitative transporters and folate receptor (FR) alpha.	Folic Acid	0-6	solute carrier family 46 member 1	Homo sapiens	99-132
28138029-1	2017	Folate uptake in epithelial ovarian cancer (EOC) involves the reduced folate carrier (RFC) and the proton-coupled folate transporter (PCFT), both facilitative transporters and folate receptor (FR) alpha.	Folic Acid	0-6	solute carrier family 46 member 1	Homo sapiens	134-138
28138029-7	2017	Two FRalpha knockdown clones (KD-4 and KD-10) showed markedly reduced binding and uptake of [3H]folic acid and [3H]AGF154 by FRalpha, but maintained high levels of [3H]AGF154 uptake by PCFT compared to nontargeted control cells.	Folic Acid	92-106	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	4-11
27883261-10	2017	CONCLUSION: Lrp2 is required for folate homeostasis in heterozygous dams and high levels of supplementation prevents NTDs.	Folic Acid	33-39	low density lipoprotein receptor-related protein 2	Mus musculus	12-16
28211874-0	2017	dATF4 regulation of mitochondrial folate-mediated one-carbon metabolism is neuroprotective.	Folic Acid	34-40	cryptocephal	Drosophila melanogaster	0-5
7078549-5	1982	In this review, we examine the properties of TSase-dUMP complexes in order to determine if there is an experimental basis for drawing a close analogy between dUMP and FdUMP in their interaction with TSase, and also to evaluate data indicating a potential chemotherapeutic value for TSase-dUMP complexes formed in the presence of folate analogs.	Folic Acid	329-335	thymidylate synthetase	Homo sapiens	45-50
28407838-12	2017	The levels of IGF-1 and IGFBP-3 in the maternal serum, as well as folate content and IGFBP-3 in the fetal brain and liver were significantly lower in the folate deficient group than in the control group (P&lt;0.05).	Folic Acid	154-160	insulin-like growth factor binding protein 3	Rattus norvegicus	85-92
28407838-13	2017	The methylation levels of IGF-1R, IGF-2R, IGFBP-2, IGFBP-5, IGFBP-6 and IGFBP-7 in the fetal brain were higher in the folate deficient group than in the control group (P&lt;0.05).	Folic Acid	118-124	insulin-like growth factor binding protein 5	Rattus norvegicus	51-58
28407838-14	2017	The methylation levels of IGF-1R, IGF-2R, IGFBP-3 and IGFBP-5 in the fetal liver were higher in the folate deficient group than in the control group.	Folic Acid	100-106	insulin-like growth factor binding protein 3	Rattus norvegicus	42-49
28407838-14	2017	The methylation levels of IGF-1R, IGF-2R, IGFBP-3 and IGFBP-5 in the fetal liver were higher in the folate deficient group than in the control group.	Folic Acid	100-106	insulin-like growth factor binding protein 5	Rattus norvegicus	54-61
7057422-8	1982	Also, both folic acid and 5-(CHO)-THF were reductively alkylated with formaldehyde to give 10-methylfolic acid (6) and 5-(CHO)-10-(CH3)-THF (28), respectively.	Folic Acid	11-21	thin fur	Mus musculus	136-139
28188287-1	2017	Dihydrofolate reductase (DHFR) plays a key role in folate metabolism and is a target molecule of methotrexate.	Folic Acid	7-13	dihydrofolate reductase	Homo sapiens	25-29
28103309-9	2017	PT newborns presented higher cord blood folate level (p = 0.049) along with lower vitamin B12 concentration compared to controls (p = 0.037).In conclusion, placental FOLR1 mRNA was positively associated with gestational age.	Folic Acid	40-46	folate receptor alpha	Homo sapiens	166-171
7140422-2	1982	Antifolate activity was measured by the deoxyuridine suppression assay, direct measurement of dihydrofolate reductase and morphological changes characteristic of folate deficiency.	Folic Acid	4-10	dihydrofolate reductase	Homo sapiens	94-117
28095689-0	2017	Folate-Binding Protein Self-Aggregation Drives Agglomeration of Folic Acid Targeted Iron Oxide Nanoparticles.	Folic Acid	64-74	folate receptor alpha	Homo sapiens	0-22
27830979-9	2017	To conclude, long-term folic acid use before and during pregnancy was associated with higher LEP and RXRA cord blood methylation, respectively.	Folic Acid	23-33	leptin	Homo sapiens	93-96
28386356-0	2017	Folic acid inhibits dedifferentiation of PDGF-BB-induced vascular smooth muscle cells by suppressing mTOR/P70S6K signaling.	Folic Acid	0-10	ribosomal protein S6 kinase B1	Homo sapiens	106-112
28386356-15	2017	CONCLUSION: Folic acid inhibits dedifferentiation of PDGF-BB-induced VSMCs by suppressing mTOR/P70S6K signaling.	Folic Acid	12-22	ribosomal protein S6 kinase B1	Homo sapiens	95-101
7140422-8	1982	Crude X-methyl folate (2X10(-1) M) is a weak folate antagonist as compared to methotrexate since it requires a 1,000-fold higher concentration to inhibit cell growth and dihydrofolate reductase activity.	Folic Acid	15-21	dihydrofolate reductase	Homo sapiens	170-193
7423195-5	1980	The folic acid pteridine and phenyl rings interact in a stacking manner which is suggestive of the type of associations these groups could form in a complex of folate, dihydrofolate reductase, and reduced nicotinamide adenine dinucleotide phosphate.	Folic Acid	4-14	dihydrofolate reductase	Homo sapiens	168-191
28278270-1	2017	BACKGROUND: gamma-Glutamyl hydrolase (GGH) regulates intracellular folates and antifolates such as methotrexate (MTX) for proper nucleotide biosynthesis and antifolate-induced cytotoxicity, respectively.	Folic Acid	67-74	gamma-glutamyl hydrolase	Homo sapiens	12-36
28278270-1	2017	BACKGROUND: gamma-Glutamyl hydrolase (GGH) regulates intracellular folates and antifolates such as methotrexate (MTX) for proper nucleotide biosynthesis and antifolate-induced cytotoxicity, respectively.	Folic Acid	67-74	gamma-glutamyl hydrolase	Homo sapiens	38-41
27998415-8	2016	An additive interaction was seen between serum folate deficiency and high expression of p16 protein in the CINI, CINII/III and SCC group.	Folic Acid	47-53	serpin family B member 3	Homo sapiens	127-130
109617-6	1979	These results strongly suggest that 4 can substitute for folate derivatives as cofactors for serine transhydroxymethylase, thymidylate synthetase, and dihydrofolate reductase.	Folic Acid	57-63	dihydrofolate reductase	Homo sapiens	93-174
27919952-3	2016	The mRNA expression levels of Alimta -target enzymes [thymidylate synthase (TYMS); dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT)], Alimta -metabolizing enzymes [gamma-glutamyl hydrase (GGH) and folylpolyglutamate synthase] and an Alimta  transporter [reduce folate carrier (RFC)] were measured and examined for potential correlations to chemosensitivity.	Folic Acid	90-96	dihydrofolate reductase	Homo sapiens	108-112
27743887-1	2017	Cerebral folate deficiency due to folate receptor 1 gene (FOLR1) mutations is an autosomal recessive disorder resulting from a brain-specific folate transport defect.	Folic Acid	9-15	folate receptor alpha	Homo sapiens	34-51
27743887-1	2017	Cerebral folate deficiency due to folate receptor 1 gene (FOLR1) mutations is an autosomal recessive disorder resulting from a brain-specific folate transport defect.	Folic Acid	9-15	folate receptor alpha	Homo sapiens	58-63
963297-6	1976	Folic acid and methyltetrahydrofolate enhanced synthesis of Me-Cbl both in normal and in PA cells, while methotrexate and 5-fluorouracil depressed it.	Folic Acid	0-10	Cbl proto-oncogene	Homo sapiens	63-66
27767239-10	2017	Nuclear beta-catenin was seen only in one PGA with focal high-grade dysplasia.	Folic Acid	42-45	catenin beta 1	Homo sapiens	8-20
963297-7	1976	This depression was overcome by 5-formyltetrahydrofolate, suggesting that an uninterrupted folate cycle may play an important role in Me-Cbl synthesis.	Folic Acid	50-56	Cbl proto-oncogene	Homo sapiens	137-140
1174694-1	1975	We studied the effect of serum folate-binding protein (FBP) on folate radioassays and the relationship of the serum level of unsaturated FBP to the serum folate level in various clinical states.	Folic Acid	63-69	folate receptor alpha	Homo sapiens	55-58
27676194-0	2017	Folic Acid Supports Pluripotency and Reprogramming by Regulating LIF/STAT3 and MAPK/ERK Signaling.	Folic Acid	0-10	leukemia inhibitory factor	Mus musculus	65-68
27618097-0	2016	Effects of Folic Acid on Secretases Involved in Abeta Deposition in APP/PS1 Mice.	Folic Acid	11-21	amyloid beta (A4) precursor protein	Mus musculus	48-53
27618097-0	2016	Effects of Folic Acid on Secretases Involved in Abeta Deposition in APP/PS1 Mice.	Folic Acid	11-21	presenilin 1	Mus musculus	72-75
27618097-4	2016	Previous studies indicated that folate deficiency elevated Abeta deposition in APP/PS1 mice, and this rise was prevented by folic acid.	Folic Acid	32-38	amyloid beta (A4) precursor protein	Mus musculus	59-64
27618097-4	2016	Previous studies indicated that folate deficiency elevated Abeta deposition in APP/PS1 mice, and this rise was prevented by folic acid.	Folic Acid	32-38	presenilin 1	Mus musculus	83-86
1174694-4	1975	Elevated levels of unsaturated FBP will produce falsely low results in folate radioassay unless the FBP has been destroyed by heat, as was done in the modified radioassay here presented.	Folic Acid	71-77	folate receptor alpha	Homo sapiens	31-34
27618097-4	2016	Previous studies indicated that folate deficiency elevated Abeta deposition in APP/PS1 mice, and this rise was prevented by folic acid.	Folic Acid	124-134	amyloid beta (A4) precursor protein	Mus musculus	59-64
27618097-4	2016	Previous studies indicated that folate deficiency elevated Abeta deposition in APP/PS1 mice, and this rise was prevented by folic acid.	Folic Acid	124-134	presenilin 1	Mus musculus	83-86
1174694-5	1975	In normal and uremic subjects, serum folate and unsaturated FBP levels tended to correlate, whereas in patients taking large doses of folic acid the level of unsaturated FBP fell as the level of serum folate rose.	Folic Acid	134-144	folate receptor alpha	Homo sapiens	170-173
27618097-5	2016	In the present study, we aimed to investigate whether folic acid could influence the generation of Abeta by regulating alpha-, beta-, and gamma-secretase.	Folic Acid	54-64	amyloid beta (A4) precursor protein	Mus musculus	99-104
1174694-5	1975	In normal and uremic subjects, serum folate and unsaturated FBP levels tended to correlate, whereas in patients taking large doses of folic acid the level of unsaturated FBP fell as the level of serum folate rose.	Folic Acid	201-207	folate receptor alpha	Homo sapiens	170-173
27618097-6	2016	Herein, we demonstrated that folic acid reduced the deposition of Abeta42 in APP/PS1 mice brain by decreasing the mRNA and protein expressions of beta-secretase [beta-site APP-cleaving enzyme 1 (BACE1)] and gamma-secretase complex catalytic component-presenilin 1 (PS1)-in APP/PS1 mice brain.	Folic Acid	29-39	presenilin 1	Mus musculus	81-84
27618097-6	2016	Herein, we demonstrated that folic acid reduced the deposition of Abeta42 in APP/PS1 mice brain by decreasing the mRNA and protein expressions of beta-secretase [beta-site APP-cleaving enzyme 1 (BACE1)] and gamma-secretase complex catalytic component-presenilin 1 (PS1)-in APP/PS1 mice brain.	Folic Acid	29-39	beta-site APP cleaving enzyme 1	Mus musculus	162-193
13704888-0	1960	Folic acid degradation by the peroxidase from Cicer arietinum.	Folic Acid	0-10	peroxidase 43	Cicer arietinum	30-40
27618097-6	2016	Herein, we demonstrated that folic acid reduced the deposition of Abeta42 in APP/PS1 mice brain by decreasing the mRNA and protein expressions of beta-secretase [beta-site APP-cleaving enzyme 1 (BACE1)] and gamma-secretase complex catalytic component-presenilin 1 (PS1)-in APP/PS1 mice brain.	Folic Acid	29-39	beta-site APP cleaving enzyme 1	Mus musculus	195-200
27618097-6	2016	Herein, we demonstrated that folic acid reduced the deposition of Abeta42 in APP/PS1 mice brain by decreasing the mRNA and protein expressions of beta-secretase [beta-site APP-cleaving enzyme 1 (BACE1)] and gamma-secretase complex catalytic component-presenilin 1 (PS1)-in APP/PS1 mice brain.	Folic Acid	29-39	presenilin 1	Mus musculus	241-263
27618097-6	2016	Herein, we demonstrated that folic acid reduced the deposition of Abeta42 in APP/PS1 mice brain by decreasing the mRNA and protein expressions of beta-secretase [beta-site APP-cleaving enzyme 1 (BACE1)] and gamma-secretase complex catalytic component-presenilin 1 (PS1)-in APP/PS1 mice brain.	Folic Acid	29-39	presenilin 1	Mus musculus	265-268
27618097-6	2016	Herein, we demonstrated that folic acid reduced the deposition of Abeta42 in APP/PS1 mice brain by decreasing the mRNA and protein expressions of beta-secretase [beta-site APP-cleaving enzyme 1 (BACE1)] and gamma-secretase complex catalytic component-presenilin 1 (PS1)-in APP/PS1 mice brain.	Folic Acid	29-39	presenilin 1	Mus musculus	265-268
27618097-7	2016	Meanwhile, folic acid increased the levels of ADAM9 and ADAM10, which are important alpha-secretases in ADAM (a disintegrin and metalloprotease) family.	Folic Acid	11-21	a disintegrin and metallopeptidase domain 10	Mus musculus	56-62
27618097-9	2016	Moreover, folic acid regulated the expression of miR-126-3p and miR-339-5p, which target ADAM9 and BACE1, respectively.	Folic Acid	10-20	beta-site APP cleaving enzyme 1	Mus musculus	99-104
27618097-10	2016	Taken together, the effect of folic acid on Abeta deposition may relate to making APP metabolism through non-amyloidogenic pathway by decreasing beta-secretase and increasing alpha-secretase.	Folic Acid	30-40	amyloid beta (A4) precursor protein	Mus musculus	44-49
14796663-0	1950	Folic acid as a growth-factor for the rat.	Folic Acid	0-10	myotrophin	Rattus norvegicus	16-29
27660437-6	2016	A widely used tumor-targeting molecule, folic acid (FA), functionalized the surface of AFn to obtain an active tumor targeting effect on MCF-7 cells and malignant tumors in mice models.	Folic Acid	40-50	ferritin heavy chain 1	Homo sapiens	87-90
18861334-0	1948	Effect of folic acid and liver extract on serum and red cell cholinesterase activity.	Folic Acid	10-20	butyrylcholinesterase	Homo sapiens	61-75
27363740-7	2016	The patient with FOLR1 gene mutation had extremely low CSF 5MTHF and total folate, though these values normalized after folinic acid supplementation.	Folic Acid	75-81	folate receptor alpha	Homo sapiens	17-22
20242341-0	1947	The influence of folic acid on serum cholinesterase activity in human subjects.	Folic Acid	17-27	butyrylcholinesterase	Homo sapiens	37-51
27620954-0	2016	Folylpoly-gamma-glutamate synthetase: A key determinant of folate homeostasis and antifolate resistance in cancer.	Folic Acid	59-65	folylpolyglutamate synthase	Homo sapiens	0-36
27620954-8	2016	An obligatory key component of intracellular folate retention and intracellular homeostasis is (anti)folate polyglutamylation, mediated by the unique enzyme folylpoly-gamma-glutamate synthetase (FPGS), which resides in both the cytoplasm and mitochondria.	Folic Acid	45-51	folylpolyglutamate synthase	Homo sapiens	157-193
33896342-4	2021	Apoferritin (AFr) functionalized with folic acid (FA) was used to encapsulate DOX to create the targeted protein nanocomplexes (TPNs).	Folic Acid	38-48	ferritin heavy chain 1	Homo sapiens	0-11
27620954-8	2016	An obligatory key component of intracellular folate retention and intracellular homeostasis is (anti)folate polyglutamylation, mediated by the unique enzyme folylpoly-gamma-glutamate synthetase (FPGS), which resides in both the cytoplasm and mitochondria.	Folic Acid	45-51	folylpolyglutamate synthase	Homo sapiens	195-199
27562465-0	2016	Mechanistic target of rapamycin (mTOR) regulates trophoblast folate uptake by modulating the cell surface expression of FR-alpha and the RFC.	Folic Acid	61-67	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	120-128
27547186-11	2016	In conclusion, certain genetic polymorphisms related to the folate transport pathway, particularly COL18A1 rs2274808, SLC19A1 rs2838956, ABCB1 rs1045642, and ABCC5 rs3792585, were associated with an increased risk for ALL in Mexican children.	Folic Acid	60-66	collagen type XVIII alpha 1 chain	Homo sapiens	99-106
33896342-4	2021	Apoferritin (AFr) functionalized with folic acid (FA) was used to encapsulate DOX to create the targeted protein nanocomplexes (TPNs).	Folic Acid	38-48	ferritin heavy chain 1	Homo sapiens	13-16
33450645-6	2021	The AuNFs-CNPs/CP sensor was also used to detect 5-mTHF in folate-rich, and was found to be twice than that of ordinary egg yolk.	Folic Acid	59-65	ceruloplasmin	Homo sapiens	15-17
27497480-11	2016	Supplementations of vitamin B6/B12/folate+choline could significantly ameliorate the hypoxia-induced memory deficits, observably decreased Hcy concentrations in serum, and markedly attenuated tau hyperphosphorylation at multiple AD-related sites through upregulating inhibitory Ser9-phosphorylated GSK-3beta.	Folic Acid	35-41	glycogen synthase kinase 3 beta	Mus musculus	298-307
27453110-9	2016	Moreover, the results by GMDR model revealed there were interaction among serum folate deficiency, RBC folate deficiency, MeCP2 protein high expression and MeCP2 mRNA high expression in SCC and CIN2 + patients.	Folic Acid	80-86	serpin family B member 3	Homo sapiens	186-189
34045473-10	2021	In summary, the data of this study showed that minor allele (A) of rs55763075 polymorphisms in the 3"-untranslated region of MTHFR mRNA generated a potential binding site for miR-34b, which led to reduced level of folic acid in the patients carrying the AA genotype.	Folic Acid	214-224	microRNA 34b	Homo sapiens	175-182
26878325-1	2016	The purpose of this study was to develop folic acid functionalized long-circulating co-encapsulated docetaxel (DTX) and curcumin (CRM) solid lipid nanoparticles (F-DC-SLN) to improve the pharmacokinetic and efficacy of DTX therapy.	Folic Acid	41-51	sarcolipin	Homo sapiens	167-170
34040256-4	2021	The proton-coupled folate transporter (PCFT) (also known as SLC46A1) mediates folate uptake across the intestinal brush border membrane and the choroid plexus4,7, and is an important route for the delivery of antifolate drugs in cancer chemotherapy8-10.	Folic Acid	19-25	solute carrier family 46 member 1	Homo sapiens	39-43
27008988-2	2016	The innate DFR1 gene in the folate synthesis pathway was found to play pivotal roles in 5-hydroxytryptophan synthesis.	Folic Acid	28-34	dihydrofolate reductase	Saccharomyces cerevisiae S288C	11-15
26884338-1	2016	The proton-coupled folate transporter (PCFT, SLC46A1) is required for intestinal folate absorption and folate homeostasis in humans.	Folic Acid	19-25	solute carrier family 46 member 1	Homo sapiens	39-43
34040256-4	2021	The proton-coupled folate transporter (PCFT) (also known as SLC46A1) mediates folate uptake across the intestinal brush border membrane and the choroid plexus4,7, and is an important route for the delivery of antifolate drugs in cancer chemotherapy8-10.	Folic Acid	19-25	solute carrier family 46 member 1	Homo sapiens	60-67
26884338-1	2016	The proton-coupled folate transporter (PCFT, SLC46A1) is required for intestinal folate absorption and folate homeostasis in humans.	Folic Acid	19-25	solute carrier family 46 member 1	Homo sapiens	45-52
34040256-5	2021	How PCFT recognizes folates or antifolate agents is currently unclear.	Folic Acid	20-27	solute carrier family 46 member 1	Homo sapiens	4-8
26884338-1	2016	The proton-coupled folate transporter (PCFT, SLC46A1) is required for intestinal folate absorption and folate homeostasis in humans.	Folic Acid	81-87	solute carrier family 46 member 1	Homo sapiens	4-37
34040256-7	2021	Our results provide a structural basis for understanding antifolate recognition and provide insights into the pH-regulated mechanism of folate transport mediated by PCFT.	Folic Acid	61-67	solute carrier family 46 member 1	Homo sapiens	165-169
26884338-1	2016	The proton-coupled folate transporter (PCFT, SLC46A1) is required for intestinal folate absorption and folate homeostasis in humans.	Folic Acid	81-87	solute carrier family 46 member 1	Homo sapiens	39-43
34008284-0	2021	Different dietary combinations of folic acid and vitamin B12 in parental diet results in epigenetic reprogramming of IGF2R and KCNQ1OT1 in placenta and fetal tissues in mice.	Folic Acid	34-44	KCNQ1 overlapping transcript 1	Mus musculus	127-135
26884338-1	2016	The proton-coupled folate transporter (PCFT, SLC46A1) is required for intestinal folate absorption and folate homeostasis in humans.	Folic Acid	81-87	solute carrier family 46 member 1	Homo sapiens	45-52
34008284-8	2021	Over-supplementation of either folate or B12 or both vitamins in comparison to BNFN, led to increase in expression of IGF2R and KCNQ1OT1 in the placenta and fetal tissues.	Folic Acid	31-37	KCNQ1 overlapping transcript 1	Mus musculus	128-136
34008284-10	2021	KCNQ1OT1 noncoding RNA (ncRNA), however, showed upregulation under deficient conditions of folate and B12 only in female fetal tissues which correlated well with hypomethylation observed under these conditions.	Folic Acid	91-97	KCNQ1 overlapping transcript 1	Mus musculus	0-8
34008284-11	2021	An epigenetic reprograming of IGF2R and KCNQ1OT1 ncRNA in the offspring was evident upon different dietary combinations of folic acid and B12 in the mice.	Folic Acid	123-133	KCNQ1 overlapping transcript 1	Mus musculus	40-48
26657220-11	2016	CONCLUSION: The Tc-Bombesin-folate heterobivalent radiopharmaceutical significantly enhances in-vivo tumour uptake because of the concomitant interaction with FRalpha and GRPR.	Folic Acid	27-34	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	159-166
33676037-0	2021	Folylpoly-gamma-glutamate synthetase association to the cytoskeleton: Implications to folate metabolon compartmentalization.	Folic Acid	86-92	folylpolyglutamate synthase	Homo sapiens	0-36
26926103-2	2016	Here, we synthesized a smart polypeptide copolymer based on n-butylamine-poly(L-lysine)-b-poly(L-cysteine) (PLL-PLC) with functionalization of folic acid (FA) and 1,2-dicarboxylic-cyclohexene anhydride (DCA) for multistage responsive tumor-targeted drug delivery.	Folic Acid	143-153	heparan sulfate proteoglycan 2	Homo sapiens	112-115
27933825-11	2016	NIR-triggered nanocomposites of UCP@SiO2:MB-NRs were significantly confirmed by improving ROS generation and further modifying folic acid (FA) to develop an active component targeting OECM-1 oral cancer cells.	Folic Acid	127-137	uncoupling protein 1	Homo sapiens	32-35
33676037-2	2021	Following carrier-mediated uptake, folates are polyglutamylated by folylpoly-gamma-glutamate synthetase (FPGS), resulting in their intracellular retention.	Folic Acid	35-42	folylpolyglutamate synthase	Homo sapiens	67-103
27013943-2	2016	They disrupt the transportation of folate across the blood-brain barrier by binding to the FRalpha.	Folic Acid	35-41	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	91-98
33676037-2	2021	Following carrier-mediated uptake, folates are polyglutamylated by folylpoly-gamma-glutamate synthetase (FPGS), resulting in their intracellular retention.	Folic Acid	35-42	folylpolyglutamate synthase	Homo sapiens	105-109
33676037-10	2021	SIGNIFICANCE: FPGS, an essential enzyme catalyzing intracellular folate polyglutamylation and efficient retention, was described as a soluble cytosolic enzyme in the past 40 years.	Folic Acid	65-71	folylpolyglutamate synthase	Homo sapiens	14-18
27013776-3	2016	To be used, folic acid must be converted to 7,8-dihydrofolate by dihydrofolate reductase to generate one-carbon derivatives serving as important cellular cofactors in the synthesis of nucleotides and amino acids required for cell growth.	Folic Acid	12-22	dihydrofolate reductase	Homo sapiens	65-88
33676037-11	2021	However, based on the lability of folates and the compartmentalization of folate metabolism and nucleotide biosynthesis, we herein hypothesized that cytoplasmic FPGS is associated with the cytoskeleton, to couple folate transport and polyglutamylation as well as channel folate polyglutamates to biosynthetic metabolon compartments.	Folic Acid	34-41	folylpolyglutamate synthase	Homo sapiens	161-165
27796090-5	2016	Moreover, the fluorescence intensity decreased significantly as the concentration of folic acid increased, and the fluorescence quenching ratio F0/F was related to the folic acid concentration in the range from 0.1 to 5 mug mL-1.	Folic Acid	85-95	L1 cell adhesion molecule	Mus musculus	224-228
27796090-5	2016	Moreover, the fluorescence intensity decreased significantly as the concentration of folic acid increased, and the fluorescence quenching ratio F0/F was related to the folic acid concentration in the range from 0.1 to 5 mug mL-1.	Folic Acid	168-178	L1 cell adhesion molecule	Mus musculus	224-228
33676037-11	2021	However, based on the lability of folates and the compartmentalization of folate metabolism and nucleotide biosynthesis, we herein hypothesized that cytoplasmic FPGS is associated with the cytoskeleton, to couple folate transport and polyglutamylation as well as channel folate polyglutamates to biosynthetic metabolon compartments.	Folic Acid	34-40	folylpolyglutamate synthase	Homo sapiens	161-165
26895662-8	2016	In both the FPGS-overexpressed HCT116 and MDA-MB-435 cell lines, we identified several differentially expressed genes involved in folate biosynthesis and one-carbon metabolism, which might in part have contributed to the observed increased efficacy of 5-fluorouracil in response to FPGS overexpression.	Folic Acid	130-136	folylpolyglutamate synthase	Homo sapiens	12-16
26895662-8	2016	In both the FPGS-overexpressed HCT116 and MDA-MB-435 cell lines, we identified several differentially expressed genes involved in folate biosynthesis and one-carbon metabolism, which might in part have contributed to the observed increased efficacy of 5-fluorouracil in response to FPGS overexpression.	Folic Acid	130-136	folylpolyglutamate synthase	Homo sapiens	282-286
33676037-11	2021	However, based on the lability of folates and the compartmentalization of folate metabolism and nucleotide biosynthesis, we herein hypothesized that cytoplasmic FPGS is associated with the cytoskeleton, to couple folate transport and polyglutamylation as well as channel folate polyglutamates to biosynthetic metabolon compartments.	Folic Acid	74-80	folylpolyglutamate synthase	Homo sapiens	161-165
33676037-11	2021	However, based on the lability of folates and the compartmentalization of folate metabolism and nucleotide biosynthesis, we herein hypothesized that cytoplasmic FPGS is associated with the cytoskeleton, to couple folate transport and polyglutamylation as well as channel folate polyglutamates to biosynthetic metabolon compartments.	Folic Acid	74-80	folylpolyglutamate synthase	Homo sapiens	161-165
33676037-13	2021	This novel cytoskeletal localization of cytoplasmic FPGS supports the dynamic channeling of polyglutamylated folates to metabolon compartments to avoid oxidation and intracellular dilution of folates, while enhancing folate-dependent de novo biosynthesis of nucleotides and DNA/protein methylation.	Folic Acid	109-116	folylpolyglutamate synthase	Homo sapiens	52-56
26929741-1	2016	BACKGROUND: Methotrexate is an important chemotherapeutic drug widely known as an inhibitor of dihydrofolate reductase (DHFR) which inhibits the reduction of folic acid.	Folic Acid	158-168	dihydrofolate reductase	Homo sapiens	120-124
33676037-13	2021	This novel cytoskeletal localization of cytoplasmic FPGS supports the dynamic channeling of polyglutamylated folates to metabolon compartments to avoid oxidation and intracellular dilution of folates, while enhancing folate-dependent de novo biosynthesis of nucleotides and DNA/protein methylation.	Folic Acid	109-115	folylpolyglutamate synthase	Homo sapiens	52-56
34004255-0	2021	hTERT-molecular targeted therapy of ovarian cancer cells via folate-functionalized PLGA nanoparticles co-loaded with MNPs/siRNA/wortmannin.	Folic Acid	61-67	telomerase reverse transcriptase	Homo sapiens	0-5
26950450-1	2016	The enzymes serine hydroxymethyltransferase 1 (SHMT1) regulate key reaction in folate-mediated one-carbon metabolism.	Folic Acid	79-85	serine hydroxymethyltransferase 1	Homo sapiens	12-45
26950450-1	2016	The enzymes serine hydroxymethyltransferase 1 (SHMT1) regulate key reaction in folate-mediated one-carbon metabolism.	Folic Acid	79-85	serine hydroxymethyltransferase 1	Homo sapiens	47-52
27809850-16	2016	CONCLUSION: The increased H3K27me3 expression might cause a disorder of folate metabolic pathway by silencing ACat2 expression, leading to reduced proliferation and differentiation of NSCs, and ultimately the occurrence of NTD.	Folic Acid	72-78	acetyl-CoA acetyltransferase 2	Rattus norvegicus	110-115
34004255-2	2021	Therefore, folate-functionalized PLGA nanoparticles (NPs) were co-loaded with hTERT siRNA, Wortmannin (Wtmn), as a potent PI3K inhibitor, and magnetic nanoparticle (MNPs) as a theranostic agent to gain a multifunctional NPs for targeted drug delivery as well as molecular targeted therapy.	Folic Acid	11-17	telomerase reverse transcriptase	Homo sapiens	78-83
33959973-0	2021	AMPK/mTOR downregulated autophagy enhances aberrant endometrial decidualization in folate-deficient pregnant mice.	Folic Acid	83-89	mechanistic target of rapamycin kinase	Mus musculus	5-9
27994750-1	2016	Current treatment of toxoplasmosis targets the parasite"s folate metabolism through inhibition of dihydrofolate reductase (DHFR).	Folic Acid	58-64	dihydrofolate reductase	Homo sapiens	123-127
26229988-2	2016	In this assay, free methotrexate and folic acid Au nanoparticles competed for human dihydrofolate reductase (hDHFR)-functionalized Au nanoparticles (Au NP).	Folic Acid	37-47	dihydrofolate reductase	Homo sapiens	109-114
33905889-11	2021	FR-alpha expression was downregulated in placental tissues of HEV infected pregnancy.Placental stress caused by HEV inflicted increased homocysteine due to alterations in maternal vitamin B12 levels and folate pathway components is detrimental mechanism in PTD and negative pregnancy outcome in HEV infected pregnancy cases and holds prognostic and therapeutic significance.	Folic Acid	203-209	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	0-8
26296240-0	2016	SERS encoded nanoparticle heterodimers for the ultrasensitive detection of folic acid.	Folic Acid	75-85	seryl-tRNA synthetase 1	Homo sapiens	0-4
26296240-2	2016	The developed SERS sensor has successful achieved the ultrasensitive detection of folic acid (FA) with the limit of detection (LOD) as 0.86 pg/mL.	Folic Acid	82-92	seryl-tRNA synthetase 1	Homo sapiens	14-18
27445334-6	2016	As a proof of concept, we chemically programmed h38C2 x v9 with hapten-folate and demonstrated its selectivity and potency against folate receptor 1 (FOLR1)-expressing ovarian cancer cells in vitro and in vivo Unlike conventional biAbs, chemically programmed biAbs in DART format are highly modular with broad utility in terms of both target and effector cell engagement.	Folic Acid	71-77	folate receptor alpha	Homo sapiens	131-148
27445334-6	2016	As a proof of concept, we chemically programmed h38C2 x v9 with hapten-folate and demonstrated its selectivity and potency against folate receptor 1 (FOLR1)-expressing ovarian cancer cells in vitro and in vivo Unlike conventional biAbs, chemically programmed biAbs in DART format are highly modular with broad utility in terms of both target and effector cell engagement.	Folic Acid	71-77	folate receptor alpha	Homo sapiens	150-155
27620954-8	2016	An obligatory key component of intracellular folate retention and intracellular homeostasis is (anti)folate polyglutamylation, mediated by the unique enzyme folylpoly-gamma-glutamate synthetase (FPGS), which resides in both the cytoplasm and mitochondria.	Folic Acid	101-107	folylpolyglutamate synthase	Homo sapiens	157-193
33852251-4	2021	RESULTS: The proportion of patients achieving PGA treatment success after 8 weeks was statistically significantly greater for CAL/BDP cream (37.4%) compared to CAL/BDP TS (22.8%, P<0.0001), and vehicle (3.7%, P<0.0001).	Folic Acid	46-49	filamin binding LIM protein 1	Homo sapiens	126-133
27620954-8	2016	An obligatory key component of intracellular folate retention and intracellular homeostasis is (anti)folate polyglutamylation, mediated by the unique enzyme folylpoly-gamma-glutamate synthetase (FPGS), which resides in both the cytoplasm and mitochondria.	Folic Acid	101-107	folylpolyglutamate synthase	Homo sapiens	195-199
27620954-10	2016	FPGS catalyzes the addition of a long polyglutamate chain to folates and antifolates, hence rendering them polyanions which are efficiently retained in the cell and are now bound with enhanced affinity by various folate-dependent enzymes.	Folic Acid	61-68	folylpolyglutamate synthase	Homo sapiens	0-4
27620954-10	2016	FPGS catalyzes the addition of a long polyglutamate chain to folates and antifolates, hence rendering them polyanions which are efficiently retained in the cell and are now bound with enhanced affinity by various folate-dependent enzymes.	Folic Acid	61-67	folylpolyglutamate synthase	Homo sapiens	0-4
27620954-11	2016	The current review highlights the crucial role that FPGS plays in maintenance of folate homeostasis under physiological conditions and delineates the plethora of the molecular mechanisms underlying loss of FPGS function and consequent antifolate resistance in cancer.	Folic Acid	81-87	folylpolyglutamate synthase	Homo sapiens	52-56
33852251-4	2021	RESULTS: The proportion of patients achieving PGA treatment success after 8 weeks was statistically significantly greater for CAL/BDP cream (37.4%) compared to CAL/BDP TS (22.8%, P<0.0001), and vehicle (3.7%, P<0.0001).	Folic Acid	46-49	filamin binding LIM protein 1	Homo sapiens	160-167
33737637-7	2021	For both classic (methotrexate, PT523) and FRalpha-targeted (AGF102) antifolates, anti-proliferative activities were antagonized by PCFT, likely due to its robust activity in mediating folate accumulation.	Folic Acid	73-79	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	43-50
33737637-7	2021	For both classic (methotrexate, PT523) and FRalpha-targeted (AGF102) antifolates, anti-proliferative activities were antagonized by PCFT, likely due to its robust activity in mediating folate accumulation.	Folic Acid	73-79	solute carrier family 46 member 1	Homo sapiens	132-136
33497860-8	2021	While compared with the control group, the expression levels of HO-1 and CHOP protein were significantly increased in the lead exposure group (P < 0.05), and the expression levels of HO-1 and CHOP protein were significantly reduced in the folic acid intervention group (P < 0.05).	Folic Acid	239-249	DNA-damage inducible transcript 3	Rattus norvegicus	192-196
27730072-13	2016	DISCUSSION: Even short-term treatment with metformin causes a decrease in serum Cbl folic acid and increase in Hcy, which leads to peripheral neuropathy in Type 2 diabetes patients.	Folic Acid	84-94	Cbl proto-oncogene	Homo sapiens	80-83
33497860-10	2021	Folic acid down-regulated the expression levels of HO-1 and CHOP proteins through the two pathways of NrF2/HO-1 and GRP78/CHOP, thereby exerting a certain protective effect and alleviating the spleen caused by lead-induced oxidative stress and endoplasmic reticulum stress damage.	Folic Acid	0-10	DNA-damage inducible transcript 3	Rattus norvegicus	60-64
27251438-1	2016	The proton-coupled folate transporter (PCFT) mediates folate absorption across the brush-border membrane of the proximal small intestine and is required for folate transport across the choroid plexus into the cerebrospinal fluid.	Folic Acid	19-25	solute carrier family 46 member 1	Homo sapiens	39-43
33497860-10	2021	Folic acid down-regulated the expression levels of HO-1 and CHOP proteins through the two pathways of NrF2/HO-1 and GRP78/CHOP, thereby exerting a certain protective effect and alleviating the spleen caused by lead-induced oxidative stress and endoplasmic reticulum stress damage.	Folic Acid	0-10	DNA-damage inducible transcript 3	Rattus norvegicus	122-126
27251438-1	2016	The proton-coupled folate transporter (PCFT) mediates folate absorption across the brush-border membrane of the proximal small intestine and is required for folate transport across the choroid plexus into the cerebrospinal fluid.	Folic Acid	54-60	solute carrier family 46 member 1	Homo sapiens	39-43
33619114-0	2021	Correction for Alam et al., Upregulation of reduced folate carrier by vitamin D enhances brain folate uptake in mice lacking folate receptor alpha.	Folic Acid	52-58	folate receptor 1 (adult)	Mus musculus	125-146
26924398-5	2016	Disturbances of folate metabolism due to genetic abnormalities or the presence of autoantibodies to folate receptor alpha (FRalpha) can impair physiologic processes dependent on folate, resulting in a variety of developmental disorders including cerebral folate deficiency syndrome and autism spectrum disorders.	Folic Acid	16-22	folate receptor alpha	Homo sapiens	100-121
26924398-5	2016	Disturbances of folate metabolism due to genetic abnormalities or the presence of autoantibodies to folate receptor alpha (FRalpha) can impair physiologic processes dependent on folate, resulting in a variety of developmental disorders including cerebral folate deficiency syndrome and autism spectrum disorders.	Folic Acid	16-22	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	123-130
33326752-3	2021	Here, we show that under physiological folate levels in the cell environment, cytosolic serine-hydroxymethyltransferase (SHMT1) is the predominant source of 1C units in a variety of cancers, while mitochondrial 1C flux is overly repressed.	Folic Acid	39-45	serine hydroxymethyltransferase 1	Homo sapiens	78-119
26924398-5	2016	Disturbances of folate metabolism due to genetic abnormalities or the presence of autoantibodies to folate receptor alpha (FRalpha) can impair physiologic processes dependent on folate, resulting in a variety of developmental disorders including cerebral folate deficiency syndrome and autism spectrum disorders.	Folic Acid	100-106	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	123-130
33326752-3	2021	Here, we show that under physiological folate levels in the cell environment, cytosolic serine-hydroxymethyltransferase (SHMT1) is the predominant source of 1C units in a variety of cancers, while mitochondrial 1C flux is overly repressed.	Folic Acid	39-45	serine hydroxymethyltransferase 1	Homo sapiens	121-126
33146801-9	2020	The molecular folic acid as a probe can specifically bound to FOLR1 with a high affinity.	Folic Acid	14-24	folate receptor alpha	Homo sapiens	62-67
27131640-9	2016	In a recent study we found that the risk for unilateral retinoblastoma in offspring is 4 fold higher in women that are homozygotes for the 19 bp deletion in the DHFR gene and took folic acid supplement during pregnancy.	Folic Acid	180-190	dihydrofolate reductase	Homo sapiens	161-165
32919191-6	2020	Folate receptor-beta (FR-beta) is a cell surface glycosylphosphatidylinositol-anchored glycoprotein that can mediate the unidirectional transport of folate into cells.	Folic Acid	149-155	folate receptor beta	Homo sapiens	0-20
27023466-1	2016	PURPOSE: In Caco-2 cells, folate uptake via the proton-coupled folate transporter (PCFT) increases significantly by a 3-day treatment with 1,25-dihydroxyvitamin D3 (1,25(OH)2D3).	Folic Acid	26-32	solute carrier family 46 member 1	Homo sapiens	48-81
27023466-1	2016	PURPOSE: In Caco-2 cells, folate uptake via the proton-coupled folate transporter (PCFT) increases significantly by a 3-day treatment with 1,25-dihydroxyvitamin D3 (1,25(OH)2D3).	Folic Acid	26-32	solute carrier family 46 member 1	Homo sapiens	83-87
32919191-6	2020	Folate receptor-beta (FR-beta) is a cell surface glycosylphosphatidylinositol-anchored glycoprotein that can mediate the unidirectional transport of folate into cells.	Folic Acid	149-155	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	22-29
27152636-7	2016	Folic acid supplementation in late gestation or throughout pregnancy significantly decreased Er-alpha, Gr and Ppar-alpha gene expression in the liver (P&lt;.05).	Folic Acid	0-10	estrogen receptor 1	Rattus norvegicus	93-101
31902944-6	2020	Synthesised lead peptide, CTVRTSAEC, bound specifically to FRalpha and could be competitively inhibited with folic acid.	Folic Acid	109-119	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	59-66
27152636-7	2016	Folic acid supplementation in late gestation or throughout pregnancy significantly decreased Er-alpha, Gr and Ppar-alpha gene expression in the liver (P&lt;.05).	Folic Acid	0-10	peroxisome proliferator activated receptor alpha	Rattus norvegicus	110-120
32800935-4	2020	The final MSN@Cy7-PA-C1b nanoparticles were wrapped by graphene oxide (GO), and then folic acid was conjugated to the surface of the MSNs for targeting purposes.	Folic Acid	85-95	moesin	Mus musculus	10-13
32269290-11	2020	Further missense or frameshift mutations were observed in the KRAS, APC, TP53, and CTNNB1 genes in the PGA group.	Folic Acid	103-106	catenin beta 1	Homo sapiens	83-89
27189966-5	2016	In mice in vivo, AEA treatment attenuated glomerular NLRP3 inflammasome activation induced by hHcys accompanying a folate-free diet, on the basis of inhibition of hHcys-induced colocalization of NLRP3 molecules and increased interleukin-1beta levels in glomeruli.	Folic Acid	115-121	NLR family, pyrin domain containing 3	Mus musculus	53-58
32998716-7	2020	In parallel, folate levels increased most substantially after the first two HD-MTX courses (until median 401.6 nmol/L, IQR 163.3-594.2) after which levels plateaued during the 3d and 4th course (until median 411.5 nmol/L, IQR 240.3-665.6).	Folic Acid	13-19	metaxin 1	Homo sapiens	79-82
27221054-6	2016	FRalpha antibodies prevented the uptake and also the corresponding conjugate without folate was not taken up.	Folic Acid	85-91	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	0-7
27221054-8	2016	An excess of free folate as competitor for the FRalpha-mediated uptake completely inhibited the photocytotoxicity.	Folic Acid	18-24	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	47-54
32998716-8	2020	The ratio folate/MTX-PG decreased significantly over time, which was mostly due to the relatively higher increase (delta) of MTX-PG.	Folic Acid	10-16	metaxin 1	Homo sapiens	125-128
27150945-0	2016	Characteristics and cytotoxicity of folate-modified curcumin-loaded PLA-PEG micellar nano systems with various PLA:PEG ratios.	Folic Acid	36-42	progestagen associated endometrial protein	Homo sapiens	72-75
27150945-0	2016	Characteristics and cytotoxicity of folate-modified curcumin-loaded PLA-PEG micellar nano systems with various PLA:PEG ratios.	Folic Acid	36-42	progestagen associated endometrial protein	Homo sapiens	115-118
32957872-9	2021	CONCLUSION: This is the first study that shows uric acid, folic acid, glutathione and ascorbic acid provide protection against the generation of toxic met-myoglobin and might be used therapeutically to modify the blood conditions in order to prevent the progression of human disorders associated with myoglobin dysfuntion.	Folic Acid	58-68	myoglobin	Homo sapiens	155-164
32957872-9	2021	CONCLUSION: This is the first study that shows uric acid, folic acid, glutathione and ascorbic acid provide protection against the generation of toxic met-myoglobin and might be used therapeutically to modify the blood conditions in order to prevent the progression of human disorders associated with myoglobin dysfuntion.	Folic Acid	58-68	myoglobin	Homo sapiens	301-310
32621820-5	2020	Then the abilities of SLC46A1 in importing heme and folate, and consequent alterations of iron content in hepatocytes were determined.	Folic Acid	52-58	solute carrier family 46 member 1	Homo sapiens	22-29
27386562-7	2016	SHMT1 encodes a serine hydroxymethyltransferase catalyzing the transfer of a carbon unit to the folate cycle.	Folic Acid	96-102	serine hydroxymethyltransferase 1	Homo sapiens	0-5
27189223-3	2016	Here, folic acid, a ligand of dihydrofolate reductase (DHFR), was hyperpolarized on (1)H spins using dissolution dynamic nuclear polarization (D-DNP).	Folic Acid	6-16	dihydrofolate reductase	Homo sapiens	30-53
27189223-3	2016	Here, folic acid, a ligand of dihydrofolate reductase (DHFR), was hyperpolarized on (1)H spins using dissolution dynamic nuclear polarization (D-DNP).	Folic Acid	6-16	dihydrofolate reductase	Homo sapiens	55-59
32621820-14	2020	CONCLUSION: The results elucidate that SLC46A1 regulates iron metabolism in the liver through a folate-independent manner of importing heme.	Folic Acid	96-102	solute carrier family 46 member 1	Homo sapiens	39-46
32621820-15	2020	The iron-responsive characters of SLC46A1 give us a new clue to link heme or iron overload with folate deficiency diseases.	Folic Acid	96-102	solute carrier family 46 member 1	Homo sapiens	34-41
32542792-6	2020	Our studies identify that RIPK3 promotes renal fibrosis via the activation of the NLRP3 inflammasome in a mouse model of folic acid-induced nephropathy.	Folic Acid	121-131	NLR family, pyrin domain containing 3	Mus musculus	82-87
26989972-5	2016	Male pups from dams fed the folic acid-supplemented diet were 3.7% heavier than those from control-fed dams and had lower mRNA expression for leptin receptor Obrb isoform (Lepr) (11%) and Agouti-related protein (Agrp) (14%).	Folic Acid	28-38	leptin receptor	Rattus norvegicus	172-176
26989972-5	2016	Male pups from dams fed the folic acid-supplemented diet were 3.7% heavier than those from control-fed dams and had lower mRNA expression for leptin receptor Obrb isoform (Lepr) (11%) and Agouti-related protein (Agrp) (14%).	Folic Acid	28-38	agouti related neuropeptide	Rattus norvegicus	188-210
26989972-5	2016	Male pups from dams fed the folic acid-supplemented diet were 3.7% heavier than those from control-fed dams and had lower mRNA expression for leptin receptor Obrb isoform (Lepr) (11%) and Agouti-related protein (Agrp) (14%).	Folic Acid	28-38	agouti related neuropeptide	Rattus norvegicus	212-216
26989972-6	2016	In contrast, female pups from folic acid-supplemented dams were 5% lighter than those from control-fed dams and had lower proopiomelanocortin (Pomc) (42%), Lepr (32%), and Agrp (13%), but higher neuropeptide Y (Npy) (18%) mRNA expression.	Folic Acid	30-40	leptin receptor	Rattus norvegicus	156-160
26989972-6	2016	In contrast, female pups from folic acid-supplemented dams were 5% lighter than those from control-fed dams and had lower proopiomelanocortin (Pomc) (42%), Lepr (32%), and Agrp (13%), but higher neuropeptide Y (Npy) (18%) mRNA expression.	Folic Acid	30-40	agouti related neuropeptide	Rattus norvegicus	172-176
27450552-1	2016	BACKGROUND: This study was carried out to evaluate the effects of folate supplementation on carotid intima-media thickness (CIMT) and metabolic status among patients with metabolic syndrome (MetS).	Folic Acid	66-72	CIMT	Homo sapiens	124-128
27450552-5	2016	RESULTS: Folate supplementation resulted in a significant reduction in maximum levels of left CIMT (-0.05 +- 0.13 vs. +0.02 +- 0.11 mm, p = 0.01) compared with the placebo.	Folic Acid	9-15	CIMT	Homo sapiens	94-98
27450552-8	2016	CONCLUSIONS: Overall, 5 mg/day folate supplementation for 12 weeks among patients with MetS had beneficial effects on CIMT and the metabolic status.	Folic Acid	31-37	CIMT	Homo sapiens	118-122
32767205-10	2020	The findings provide insight into the debatable roles of MTHFR in fertility and may be applicable for the improvement of care for early embryos via modulation of surrounding folate-related nutritional conditions in vitro and/or in utero, depending on the parental and embryonic MTHFR genotype.	Folic Acid	174-180	methylenetetrahydrofolate reductase	Bos taurus	57-62
26881719-6	2016	DHFR, an enzyme of the folate biosynthesis pathway is an established chemotherapeutic target, initially explored for anti-cancer drug discovery.	Folic Acid	23-29	dihydrofolate reductase	Homo sapiens	0-4
27738387-7	2016	We also observed that folic acid dose-dependently upregulated both SOCS1 and SOCS3 expression in BV-2 cells, leading to an increased expression of the anti-inflammatory cytokine IL-10.	Folic Acid	22-32	suppressor of cytokine signaling 3	Mus musculus	77-82
26482924-3	2016	We have carried out the chemical shift assignments for H(N), N(H), C(alpha) and C(beta) atoms of the Gly67Val mutant of E. coli DHFR complexed with folate at pH 7.0, 35  C, and then evaluated the H(N), N(H), C(alpha) and C(beta) chemical shift changes caused by the mutation.	Folic Acid	148-154	Dihydrofolate reductase	Escherichia coli	128-132
27022421-3	2016	This study aimed to investigate the anti-tumor response of a combination therapy employing folate-modified chitosan nanoparticles containing IP-10 (interferon-gamma-inducible protein-10) plus melanoma TRP2-specific CD8(+)CD28(+) T cells.	Folic Acid	91-97	tRNA proline 2	Mus musculus	201-205
27022421-4	2016	METHODS: We prepared folate-modified chitosan nanoparticles containing the mouse IP-10 gene (FA-CS-mIP-10), and induced melanoma TRP2-specific CD8(+)CD28(+) T cells by co-culturing them with artificial antigen-presenting cells.	Folic Acid	21-27	tRNA proline 2	Mus musculus	129-133
26895662-1	2016	Folylpolyglutamate synthase (FPGS) plays a critical role in intracellular folate homeostasis.	Folic Acid	74-80	folylpolyglutamate synthase	Homo sapiens	0-27
26895662-1	2016	Folylpolyglutamate synthase (FPGS) plays a critical role in intracellular folate homeostasis.	Folic Acid	74-80	folylpolyglutamate synthase	Homo sapiens	29-33
32767205-10	2020	The findings provide insight into the debatable roles of MTHFR in fertility and may be applicable for the improvement of care for early embryos via modulation of surrounding folate-related nutritional conditions in vitro and/or in utero, depending on the parental and embryonic MTHFR genotype.	Folic Acid	174-180	methylenetetrahydrofolate reductase	Bos taurus	278-283
27064332-0	2016	Assessment of Folic Acid Supplementation in Pregnant Women by Estimation of Serum Levels of Tetrahydrofolic Acid, Dihydrofolate Reductase, and Homocysteine.	Folic Acid	14-24	dihydrofolate reductase	Homo sapiens	114-137
32238907-8	2020	Four exonic CpG-SNPs of MTHFD1, MTRR, and GGH genes were identified in folate pathway genes.	Folic Acid	71-77	gamma-glutamyl hydrolase	Homo sapiens	42-45
26666829-1	2015	BACKGROUND: Serine hydroxymethyltransferase 1 (SHMT1) is a key enzyme in the folate metabolic pathway that plays an important role in biosynthesis by providing one carbon unit.	Folic Acid	77-83	serine hydroxymethyltransferase 1	Homo sapiens	12-45
26666829-1	2015	BACKGROUND: Serine hydroxymethyltransferase 1 (SHMT1) is a key enzyme in the folate metabolic pathway that plays an important role in biosynthesis by providing one carbon unit.	Folic Acid	77-83	serine hydroxymethyltransferase 1	Homo sapiens	47-52
32752079-2	2020	A known folate antagonist, methotrexate (MTX) inhibits human dihydrofolate reductase (hDHFR), the enzyme responsible for the catalysis of 7,8-dihydrofolate reduction to 5,6,7,8-tetrahydrofolate, in biosynthesis and cell proliferation.	Folic Acid	8-14	dihydrofolate reductase	Homo sapiens	61-84
26476917-3	2015	This study reports on a core/shell-based theranostic system designed by UCN integration with a folate (FA)-conjugated dendrimer for tumor targeting and with photocaged doxorubicin as a cytotoxic agent.	Folic Acid	95-101	urocortin	Homo sapiens	72-75
26438060-1	2016	The 5,10-methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS) are critical enzymes in folate metabolism.	Folic Acid	28-34	thymidylate synthetase	Homo sapiens	79-81
26438060-3	2016	We investigated the risks of adult leukemia with genetic polymorphisms of folate metabolic enzymes (MTHFR C677T, A1298C, and TS) and evaluated if the associations varied by dietary folate intake from a multicenter case-control study conducted in Chinese.	Folic Acid	74-80	thymidylate synthetase	Homo sapiens	125-127
26438060-9	2016	Stratified analysis by dietary folate intake showed the increased risks of leukemia with the MTHFR 677TT and TS 2R3R/2R2R genotypes were only significant in individuals with low folate intake.	Folic Acid	31-37	thymidylate synthetase	Homo sapiens	109-111
26438060-9	2016	Stratified analysis by dietary folate intake showed the increased risks of leukemia with the MTHFR 677TT and TS 2R3R/2R2R genotypes were only significant in individuals with low folate intake.	Folic Acid	178-184	thymidylate synthetase	Homo sapiens	109-111
32752079-2	2020	A known folate antagonist, methotrexate (MTX) inhibits human dihydrofolate reductase (hDHFR), the enzyme responsible for the catalysis of 7,8-dihydrofolate reduction to 5,6,7,8-tetrahydrofolate, in biosynthesis and cell proliferation.	Folic Acid	8-14	dihydrofolate reductase	Homo sapiens	86-91
26438060-10	2016	A significant interaction between TS polymorphism and dietary folate intake was observed (P = 0.03).	Folic Acid	62-68	thymidylate synthetase	Homo sapiens	34-36
26438060-11	2016	This study suggests that dietary folate intake and gender may modify the associations between MTHFR/TS polymorphisms and adult leukemia risk.	Folic Acid	33-39	thymidylate synthetase	Homo sapiens	100-102
32774701-3	2020	Folic acid was used to induce kidney injury C57BL/6 mouse model followed by analysis of serum creatinine, renal weight ratio changes, renal pathological changes and STAT3/mTOR pathway changes.	Folic Acid	0-10	mechanistic target of rapamycin kinase	Mus musculus	171-175
26929741-1	2016	BACKGROUND: Methotrexate is an important chemotherapeutic drug widely known as an inhibitor of dihydrofolate reductase (DHFR) which inhibits the reduction of folic acid.	Folic Acid	158-168	dihydrofolate reductase	Homo sapiens	95-118
26505396-7	2015	Downregulation of Bc1-2 expression and upregulation of Bax expression were observed in the neurons of folic acid-treated rats.	Folic Acid	102-112	brain cytoplasmic RNA 1	Rattus norvegicus	18-23
26505396-7	2015	Downregulation of Bc1-2 expression and upregulation of Bax expression were observed in the neurons of folic acid-treated rats.	Folic Acid	102-112	BCL2 associated X, apoptosis regulator	Rattus norvegicus	55-58
26198726-14	2015	GGH was associated with folate metabolism in PYD cases, IGHG3 was linked to the control of Mycobacterium infection in HFYD patients, and HPT was involved in hypoxia in DQY patients.	Folic Acid	24-30	gamma-glutamyl hydrolase	Homo sapiens	0-3
32774701-7	2020	Folic acid-induced injury of mesangial cells showed inhibited cell proliferation, promoted apoptosis, increased LC3II expression, decreased p62 expression, increased autophagic vacuoles and expression of STAT3 and p-mTOR as well as decreased E-cadherin expression and increased Vimentin expression.	Folic Acid	0-10	mechanistic target of rapamycin kinase	Mus musculus	216-220
32329959-5	2020	In proof-of-concept studies, this cp-Fab/CAR-T system targeting folate binding sites in the cell surfaceome mediated potent and specific eradication of folate receptor-expressing cancer cells in vitro and in vivo .	Folic Acid	64-70	FA complementation group B	Homo sapiens	37-40
26674922-10	2015	Stimulation with excess folate increased expression of miR-21 in colon cancer cell lines.	Folic Acid	24-30	microRNA 21	Homo sapiens	55-61
26674922-11	2015	GENERAL SIGNIFICANCE: This study demonstrates that serum miR-21 expression correlates with folate status and related genetic status.	Folic Acid	91-97	microRNA 21	Homo sapiens	57-63
27047750-1	2016	The proton-coupled folate transporter (PCFT, SLC46A1) transports folic acid across the plasma membrane, together with an excess of protons such that the net charge translocation is positive.	Folic Acid	65-75	solute carrier family 46 member 1	Homo sapiens	39-43
27047750-1	2016	The proton-coupled folate transporter (PCFT, SLC46A1) transports folic acid across the plasma membrane, together with an excess of protons such that the net charge translocation is positive.	Folic Acid	65-75	solute carrier family 46 member 1	Homo sapiens	45-52
32329959-5	2020	In proof-of-concept studies, this cp-Fab/CAR-T system targeting folate binding sites in the cell surfaceome mediated potent and specific eradication of folate receptor-expressing cancer cells in vitro and in vivo .	Folic Acid	64-70	CXADR pseudogene 1	Homo sapiens	41-44
26667416-6	2016	Results in the SHR.BN-chr.1 congenic strain confirmed that the SHR variant in Folr1 cosegregates with markedly reduced renal expression of Folr1 and renal folate reabsorption, decreased serum levels of folate, increased serum levels of cysteine and homocysteine, increased adiposity, ectopic fat accumulation in liver and muscle, reduced muscle insulin sensitivity, and increased blood pressure.	Folic Acid	155-161	folate receptor alpha	Rattus norvegicus	78-83
26667416-6	2016	Results in the SHR.BN-chr.1 congenic strain confirmed that the SHR variant in Folr1 cosegregates with markedly reduced renal expression of Folr1 and renal folate reabsorption, decreased serum levels of folate, increased serum levels of cysteine and homocysteine, increased adiposity, ectopic fat accumulation in liver and muscle, reduced muscle insulin sensitivity, and increased blood pressure.	Folic Acid	202-208	folate receptor alpha	Rattus norvegicus	78-83
25791804-1	2015	UNLABELLED: Folic Acid (FA)-tagged protein nanoemulsions were found to be preferentially internalized on B-cell lymphoma cell line (A20 cell line), which, for the first time, is reported to express folate receptor (FR)-alpha.	Folic Acid	12-22	folate receptor 1 (adult)	Mus musculus	198-224
33463352-7	2020	In summary, the results of this study revealed that US-MB-mediated codelivery of SIK2 siRNA, and anti-miR21 encapsulated in a folate-lipid-PLGA hybrid polymer nanoparticle could significantly improve the sensitivity of EOC tumors to PTX and is a highly effective approach for treating EOC in complementary experiments.	Folic Acid	126-132	microRNA 21	Homo sapiens	102-107
25860940-2	2015	We have identified folate-mediated one-carbon metabolism as highly upregulated in neuroblastoma tumors with MYCN amplification and have validated this finding experimentally by showing that MYCN amplified neuroblastoma cell lines have a higher requirement for folate and are significantly more sensitive to the antifolate methotrexate than cell lines without MYCN amplification.	Folic Acid	260-266	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	190-194
25860940-2	2015	We have identified folate-mediated one-carbon metabolism as highly upregulated in neuroblastoma tumors with MYCN amplification and have validated this finding experimentally by showing that MYCN amplified neuroblastoma cell lines have a higher requirement for folate and are significantly more sensitive to the antifolate methotrexate than cell lines without MYCN amplification.	Folic Acid	260-266	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	190-194
25860940-5	2015	This study adds upregulation of folate-mediated one-carbon metabolism to the known consequences of MYCN amplification, and suggests that this pathway might be targeted in poor outcome tumors with MYCN amplification and high SLC19A1 expression.	Folic Acid	32-38	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	99-103
25860940-5	2015	This study adds upregulation of folate-mediated one-carbon metabolism to the known consequences of MYCN amplification, and suggests that this pathway might be targeted in poor outcome tumors with MYCN amplification and high SLC19A1 expression.	Folic Acid	32-38	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	196-200
26229988-2	2016	In this assay, free methotrexate and folic acid Au nanoparticles competed for human dihydrofolate reductase (hDHFR)-functionalized Au nanoparticles (Au NP).	Folic Acid	37-47	dihydrofolate reductase	Homo sapiens	84-107
31739736-1	2020	INTRODUCTION: Raltitrexed is a folate analogue, which selectively inhibits thymidylate synthase, used in the treatment of colorectal carcinoma.	Folic Acid	31-37	thymidylate synthetase	Homo sapiens	75-95
25651436-0	2015	Folic acid inhibits tau phosphorylation through regulation of PP2A methylation in SH-SY5Y cells.	Folic Acid	0-10	microtubule associated protein tau	Homo sapiens	20-23
32555504-1	2020	Human arylamine N-acetyltransferase 1 (NAT1), present in all tissues, is classically described as a phase-II xenobiotic metabolizing enzyme but can also catalyze the hydrolysis of acetyl-Coenzyme A (acetyl-CoA) in the absence of an arylamine substrate using folate as a cofactor.	Folic Acid	258-264	N-acetyltransferase 1	Homo sapiens	6-37
25651436-0	2015	Folic acid inhibits tau phosphorylation through regulation of PP2A methylation in SH-SY5Y cells.	Folic Acid	0-10	protein phosphatase 2 phosphatase activator	Homo sapiens	62-66
25651436-4	2015	Folic acid can downregulate tau protein phosphorylation by inhibiting the demethylation reactions of PP2A.	Folic Acid	0-10	microtubule associated protein tau	Homo sapiens	28-31
25651436-4	2015	Folic acid can downregulate tau protein phosphorylation by inhibiting the demethylation reactions of PP2A.	Folic Acid	0-10	protein phosphatase 2 phosphatase activator	Homo sapiens	101-105
26795251-3	2016	Here, we describe MR1 autoreactivity and folate-derivative reactivity in a discrete subset of TRAV1-2(+) MAIT cells.	Folic Acid	41-47	T cell receptor alpha variable 1-2	Homo sapiens	94-101
26795251-5	2016	Furthermore, we have demonstrated differential folate- and riboflavin-derivative reactivity by a diverse population of "atypical" TRAV1-2(-) MR1-restricted T cells.	Folic Acid	47-53	T cell receptor alpha variable 1-2	Homo sapiens	130-137
32555504-1	2020	Human arylamine N-acetyltransferase 1 (NAT1), present in all tissues, is classically described as a phase-II xenobiotic metabolizing enzyme but can also catalyze the hydrolysis of acetyl-Coenzyme A (acetyl-CoA) in the absence of an arylamine substrate using folate as a cofactor.	Folic Acid	258-264	N-acetyltransferase 1	Homo sapiens	39-43
26636884-0	2016	Folate Receptor Targeted Delivery of siRNA and Paclitaxel to Ovarian Cancer Cells via Folate Conjugated Triblock Copolymer to Overcome TLR4 Driven Chemotherapy Resistance.	Folic Acid	0-6	toll like receptor 4	Homo sapiens	135-139
25495051-6	2015	GRMZM2G393334 encodes a putative folylpolyglutamate synthase (FPGS), which functions in one-carbon (C1) metabolism to polyglutamylate substrates of folate-dependent enzymes.	Folic Acid	148-154	folylpolyglutamate synthase	Zea mays	33-60
32545327-1	2020	The folate receptor (FR) is a promising cell membrane-associated target for molecular imaging and radionuclide therapy of cancer (FR-alpha) and potentially also inflammatory diseases (FR-beta) through use of folic acid-based radioconjugate.	Folic Acid	208-218	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	130-138
25495051-6	2015	GRMZM2G393334 encodes a putative folylpolyglutamate synthase (FPGS), which functions in one-carbon (C1) metabolism to polyglutamylate substrates of folate-dependent enzymes.	Folic Acid	148-154	folylpolyglutamate synthase	Zea mays	62-66
25315410-2	2015	Sulfonamide antibiotics block synthesis of folic acid by inhibiting dihydrofolate reductase (DHFR) while TCS block fatty acid synthesis through inhibition of enoyl-ACP reductase (FabI).	Folic Acid	43-53	dihydrofolate reductase	Homo sapiens	68-91
27509954-9	2016	Combined folate and methionine depletion led to a significant downregulation of Dnmt3a and Dnmt3b; this was associated with an 18% reduction in global DNA methylation compared with controls.	Folic Acid	9-15	DNA methyltransferase 3 alpha	Homo sapiens	80-86
27509954-9	2016	Combined folate and methionine depletion led to a significant downregulation of Dnmt3a and Dnmt3b; this was associated with an 18% reduction in global DNA methylation compared with controls.	Folic Acid	9-15	DNA methyltransferase 3 beta	Homo sapiens	91-97
32545327-1	2020	The folate receptor (FR) is a promising cell membrane-associated target for molecular imaging and radionuclide therapy of cancer (FR-alpha) and potentially also inflammatory diseases (FR-beta) through use of folic acid-based radioconjugate.	Folic Acid	208-218	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	184-191
27509954-10	2016	Effects of folate and methionine depletion on Dnmt3a and 3b expression were reversed by transferring depleted cells to complete medium.	Folic Acid	11-17	DNA methyltransferase 3 alpha	Homo sapiens	46-58
25315410-2	2015	Sulfonamide antibiotics block synthesis of folic acid by inhibiting dihydrofolate reductase (DHFR) while TCS block fatty acid synthesis through inhibition of enoyl-ACP reductase (FabI).	Folic Acid	43-53	dihydrofolate reductase	Homo sapiens	93-97
32498709-2	2020	We thus wished to determine whether the inefficiency in folate metabolism caused by genetic variation in the MTHFR and DHFR genes in folate metabolism, or inadequate folate intake, is associated with obesity.	Folic Acid	56-62	dihydrofolate reductase	Homo sapiens	119-123
25559736-7	2015	One of the salient observations of this study was a coupled increase in the expression of renal, relA, NF-kB2, and p53 genes and proteins during folic acid induced AKI (FA AKI).	Folic Acid	145-155	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	97-101
26107232-1	2015	BACKGROUND: Folylpolyglutamate synthetase (FPGS), an important enzyme in the folate metabolic pathway, plays a central role in intracellular accumulation of folate and antifolate in several mammalian cell types.	Folic Acid	77-83	folylpolyglutamate synthase	Homo sapiens	12-41
26520043-0	2016	Tailored-CuO-nanowire decorated with folic acid mediated coupling of the mitochondrial-ROS generation and miR425-PTEN axis in furnishing potent anti-cancer activity in human triple negative breast carcinoma cells.	Folic Acid	37-47	phosphatase and tensin homolog	Homo sapiens	113-117
32498709-2	2020	We thus wished to determine whether the inefficiency in folate metabolism caused by genetic variation in the MTHFR and DHFR genes in folate metabolism, or inadequate folate intake, is associated with obesity.	Folic Acid	133-139	dihydrofolate reductase	Homo sapiens	119-123
26107232-1	2015	BACKGROUND: Folylpolyglutamate synthetase (FPGS), an important enzyme in the folate metabolic pathway, plays a central role in intracellular accumulation of folate and antifolate in several mammalian cell types.	Folic Acid	77-83	folylpolyglutamate synthase	Homo sapiens	43-47
32498709-2	2020	We thus wished to determine whether the inefficiency in folate metabolism caused by genetic variation in the MTHFR and DHFR genes in folate metabolism, or inadequate folate intake, is associated with obesity.	Folic Acid	133-139	dihydrofolate reductase	Homo sapiens	119-123
26107232-1	2015	BACKGROUND: Folylpolyglutamate synthetase (FPGS), an important enzyme in the folate metabolic pathway, plays a central role in intracellular accumulation of folate and antifolate in several mammalian cell types.	Folic Acid	157-163	folylpolyglutamate synthase	Homo sapiens	12-41
26107232-1	2015	BACKGROUND: Folylpolyglutamate synthetase (FPGS), an important enzyme in the folate metabolic pathway, plays a central role in intracellular accumulation of folate and antifolate in several mammalian cell types.	Folic Acid	157-163	folylpolyglutamate synthase	Homo sapiens	43-47
32057865-0	2020	Folate receptor alpha targeted delivery of artemether to breast cancer cells with folate-decorated human serum albumin nanoparticles.	Folic Acid	82-88	folate receptor alpha	Homo sapiens	0-21
26885500-5	2015	This effect was concomitant with a much lessened accumulation of fibronectin and collagen in tubulointerstitium 28 days after folic acid injury, denoting an ameliorated renal fibrosis.	Folic Acid	126-136	fibronectin 1	Mus musculus	65-76
26407224-4	2015	Furthermore, the VUV CD spectrum and the folate- or NADP(+)-induced spectral change of F103L mutant DHFR indicated a modification and regeneration of exciton coupling between the Trp47 and Trp74 side chains, respectively, suggesting that exciton coupling may also contribute to the CD spectrum of DHFR in the VUV region.	Folic Acid	41-47	Dihydrofolate reductase	Escherichia coli	100-104
26407224-4	2015	Furthermore, the VUV CD spectrum and the folate- or NADP(+)-induced spectral change of F103L mutant DHFR indicated a modification and regeneration of exciton coupling between the Trp47 and Trp74 side chains, respectively, suggesting that exciton coupling may also contribute to the CD spectrum of DHFR in the VUV region.	Folic Acid	41-47	Dihydrofolate reductase	Escherichia coli	297-301
32057865-3	2020	In further, folate-decorated ARM-HSA NPs (F-ARM-HSA NPs) were developed to enhance targeted delivery to folate receptor alpha (FRalpha)-overexpressing breast cancer cells.	Folic Acid	12-18	folate receptor alpha	Homo sapiens	104-125
26116148-1	2015	This review analyzes how interplay between folate binding and changes in folate binding protein (FBP) conformation/self-association affects the biological function of FBP.	Folic Acid	43-49	folate receptor alpha	Homo sapiens	167-170
32057865-3	2020	In further, folate-decorated ARM-HSA NPs (F-ARM-HSA NPs) were developed to enhance targeted delivery to folate receptor alpha (FRalpha)-overexpressing breast cancer cells.	Folic Acid	12-18	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	127-134
26116148-2	2015	Concentration-dependent, reversible self-association of hydrophobic apo-FBP at pI=7.4 is associated with decreased affinity for folate, probably due to shielding of binding sites between interacting hydrophobic patches.	Folic Acid	128-134	folate receptor alpha	Homo sapiens	72-75
26594608-6	2015	The differences in the in vivo production of folate by HRB and non-HRB were confirmed using mono-associated mice.	Folic Acid	45-51	ArfGAP with FG repeats 1	Mus musculus	55-58
26116148-3	2015	Titration with folate removes apo-monomers, favoring dissociation of self-associated apo-FBP into apo-monomers.	Folic Acid	15-21	folate receptor alpha	Homo sapiens	89-92
32152484-1	2020	Folate receptor alpha (FRalpha) came into focus as an anticancer target many decades after the successful development of drugs targeting intracellular folate metabolism, such as methotrexate and pemetrexed.	Folic Acid	151-157	folate receptor alpha	Homo sapiens	0-21
26116148-4	2015	Folate anchors to FBP through a network of hydrogen bonds and hydrophobic interactions, and the binding induces a conformational change with formation of hydrophilic and stable holo-FBP.	Folic Acid	0-6	folate receptor alpha	Homo sapiens	18-21
26116148-4	2015	Folate anchors to FBP through a network of hydrogen bonds and hydrophobic interactions, and the binding induces a conformational change with formation of hydrophilic and stable holo-FBP.	Folic Acid	0-6	folate receptor alpha	Homo sapiens	182-185
26594608-10	2015	Our results confirmed the differences in folate production between HRB and non-HRB strains and suggested the benefit of HRB to hosts from the perspective of potential folate delivery.	Folic Acid	41-47	ArfGAP with FG repeats 1	Mus musculus	67-70
26594608-10	2015	Our results confirmed the differences in folate production between HRB and non-HRB strains and suggested the benefit of HRB to hosts from the perspective of potential folate delivery.	Folic Acid	41-47	ArfGAP with FG repeats 1	Mus musculus	79-82
26594608-10	2015	Our results confirmed the differences in folate production between HRB and non-HRB strains and suggested the benefit of HRB to hosts from the perspective of potential folate delivery.	Folic Acid	41-47	ArfGAP with FG repeats 1	Mus musculus	79-82
26403086-1	2015	Myricetin is a flavonoid that has recently been suggested to induce sustained inhibition of proton-coupled folate transporter (PCFT/SLC46A1), which operates for intestinal folate uptake.	Folic Acid	107-113	solute carrier family 46 member 1	Homo sapiens	127-131
32152484-1	2020	Folate receptor alpha (FRalpha) came into focus as an anticancer target many decades after the successful development of drugs targeting intracellular folate metabolism, such as methotrexate and pemetrexed.	Folic Acid	151-157	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	23-30
26310574-8	2015	In addition, western blot analysis revealed that the expression levels of the muscle-specific marker, myosin heavy chain (MyHC), as well as those of the myogenic regulatory factors (MRFs), MyoD and myogenin, were increased in the folic acid-treated myotubes during myogenic differentiation.	Folic Acid	230-240	myogenic differentiation 1	Mus musculus	189-193
26310574-8	2015	In addition, western blot analysis revealed that the expression levels of the muscle-specific marker, myosin heavy chain (MyHC), as well as those of the myogenic regulatory factors (MRFs), MyoD and myogenin, were increased in the folic acid-treated myotubes during myogenic differentiation.	Folic Acid	230-240	myogenin	Mus musculus	198-206
25629224-7	2015	Several SNPs in MAP3K9 were associated with ER+/PR+ tumors and interacted with dietary oxidative balance score (DOBS), dietary folate, body mass index (BMI), alcohol consumption, cigarette smoking, and a history of diabetes.	Folic Acid	127-133	mitogen-activated protein kinase kinase kinase 9	Homo sapiens	16-22
32469605-0	2020	Effect of folic acid and vitamin E on promoter DNA methylation and expression of TGF-beta1, ESR-1 and CDH-1 in the uterus of STZ-induced diabetic rats.	Folic Acid	10-20	estrogen receptor 1	Rattus norvegicus	92-97
24867254-9	2015	The results showed that physicochemical characteristics of folic acid affect its dissolution and absorption making it difficult to take a decision on their biowaiver based on BCS.	Folic Acid	59-69	BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone	Homo sapiens	175-178
32469605-0	2020	Effect of folic acid and vitamin E on promoter DNA methylation and expression of TGF-beta1, ESR-1 and CDH-1 in the uterus of STZ-induced diabetic rats.	Folic Acid	10-20	cadherin 1	Rattus norvegicus	102-107
32476787-0	2020	Folic acid attenuates high-fat diet-induced steatohepatitis via deacetylase SIRT1-dependent restoration of PPARalpha.	Folic Acid	0-10	peroxisome proliferator activated receptor alpha	Rattus norvegicus	107-116
26238535-1	2015	OBJECTIVE: Cellular uptake of folate is mediated by folate receptor (FR)alpha.	Folic Acid	30-36	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	69-77
32476787-8	2020	Furthermore, peroxisome proliferator-activated receptor alpha (PPARalpha) and silence information regulation factor 1 (SIRT1) were restored by folic acid in HFD-fed rats and palmitic acid-exposed Huh7 cell line.	Folic Acid	143-153	peroxisome proliferator activated receptor alpha	Rattus norvegicus	13-61
32476787-8	2020	Furthermore, peroxisome proliferator-activated receptor alpha (PPARalpha) and silence information regulation factor 1 (SIRT1) were restored by folic acid in HFD-fed rats and palmitic acid-exposed Huh7 cell line.	Folic Acid	143-153	peroxisome proliferator activated receptor alpha	Rattus norvegicus	63-72
25453083-4	2014	To resolve this ambiguity, we conducted neutron and ultrahigh-resolution X-ray crystallographic studies of the pseudo-Michaelis ternary complex of Escherichia coli DHFR with folate and NADP(+).	Folic Acid	174-180	Dihydrofolate reductase	Escherichia coli	164-168
32295203-6	2020	Leukemic CCRF-CEM cells and the MTX-resistant variant (CEM/MTX, with a deficient reduced folate carrier) have a very low expression of PCFT due to promoter hypermethylation.	Folic Acid	89-95	solute carrier family 46 member 1	Homo sapiens	135-139
25359878-2	2014	Activated macrophages express folate receptor-beta (FR-beta), which can be targeted by folate coupled to radioactive ligands to visualize vulnerability.	Folic Acid	30-36	folate receptor beta	Homo sapiens	52-59
26256755-0	2015	Characterization of Folic Acid and Poly(amidoamine) Dendrimer Interactions with Folate Binding Protein: A Force-Pulling Study.	Folic Acid	20-30	folate receptor alpha	Homo sapiens	80-102
26256755-1	2015	Atomic force microscopy force-pulling experiments have been used to measure the binding forces between folic acid (FA) conjugated poly(amidoamine) (PAMAM) dendrimers and folate binding protein (FBP).	Folic Acid	103-113	folate receptor alpha	Homo sapiens	170-192
26256755-1	2015	Atomic force microscopy force-pulling experiments have been used to measure the binding forces between folic acid (FA) conjugated poly(amidoamine) (PAMAM) dendrimers and folate binding protein (FBP).	Folic Acid	103-113	folate receptor alpha	Homo sapiens	194-197
26309907-2	2015	Recently, studies report that human NAT1 and mouse Nat2 hydrolyze acetyl-coenzyme A (AcCoA) into acetate and coenzyme A in a folate-dependent fashion, a previously unknown function.	Folic Acid	125-131	N-acetyltransferase 1	Homo sapiens	36-40
31504777-7	2020	RESULTS: Nlrp6 was expressed by healthy murine and human kidney tubular epithelium, and expression was reduced during human kidney injury or murine nephrotoxic AKI induced by cisplatin or a folic acid overdose.	Folic Acid	190-200	NLR family, pyrin domain containing 6	Mus musculus	9-14
26309907-3	2015	In this study, our goal was to confirm these findings and determine the apparent Michaelis-Menten kinetic constants (Vmax and Km) of the folate-dependent AcCoA hydrolysis for human NAT1/NAT2, and the rodent analogs rat Nat1/Nat2, mouse Nat1/Nat2, and hamster Nat1/Nat2.	Folic Acid	137-143	N-acetyltransferase 1	Homo sapiens	181-185
26309907-3	2015	In this study, our goal was to confirm these findings and determine the apparent Michaelis-Menten kinetic constants (Vmax and Km) of the folate-dependent AcCoA hydrolysis for human NAT1/NAT2, and the rodent analogs rat Nat1/Nat2, mouse Nat1/Nat2, and hamster Nat1/Nat2.	Folic Acid	137-143	N-acetyl transferase 1	Mus musculus	236-240
26309907-3	2015	In this study, our goal was to confirm these findings and determine the apparent Michaelis-Menten kinetic constants (Vmax and Km) of the folate-dependent AcCoA hydrolysis for human NAT1/NAT2, and the rodent analogs rat Nat1/Nat2, mouse Nat1/Nat2, and hamster Nat1/Nat2.	Folic Acid	137-143	N-acetyltransferase 1	Homo sapiens	236-240
26309907-5	2015	Human NAT1 and its rodent analogs rat Nat2, mouse Nat2 and hamster Nat2 catalyzed AcCoA hydrolysis in a folate-dependent manner.	Folic Acid	104-110	N-acetyltransferase 1	Homo sapiens	6-10
25364408-4	2014	The folate metabolizing enzymes studied were folypolyglutamate synthetase, gamma-glutamyl hydrolase and dihydrofolate reductase.	Folic Acid	4-10	gamma-glutamyl hydrolase	Homo sapiens	75-99
25037819-6	2014	Folate caused a dose-dependent decrease in transcript abundance of peroxisome proliferator-activated receptor gamma (PPARgamma), CCAAT/enhancer-binding protein alpha (C/EBPalpha) gene expression, and the downstream enzyme fatty acid synthase; in contrast, expression of DNA (cytosine-5)-methyltransferase and methylenetetrahydrofolate reductase was obviously upregulated at d 6 of differentiation (P &lt; 0.05).	Folic Acid	0-6	fatty acid synthase	Gallus gallus	222-241
31884393-1	2020	A novel fluorescent probe for detection of HT 29 cancer cells was developed based on terbium-doped dendritic fibrous nanosilica functionalized by folic acid (Tb@KCC-1-NH2-FA).	Folic Acid	146-156	solute carrier family 12 member 4	Homo sapiens	161-166
25037819-6	2014	Folate caused a dose-dependent decrease in transcript abundance of peroxisome proliferator-activated receptor gamma (PPARgamma), CCAAT/enhancer-binding protein alpha (C/EBPalpha) gene expression, and the downstream enzyme fatty acid synthase; in contrast, expression of DNA (cytosine-5)-methyltransferase and methylenetetrahydrofolate reductase was obviously upregulated at d 6 of differentiation (P &lt; 0.05).	Folic Acid	0-6	methylenetetrahydrofolate reductase	Gallus gallus	309-344
24739308-6	2014	Here, we report the epistatic interaction between dhfr mutations and amplification of the gene encoding the first upstream enzyme in the folate pathway, GTP cyclohydrolase I (GCH1).	Folic Acid	137-143	dihydrofolate reductase	Homo sapiens	50-54
26144049-3	2015	The present study reveals that pharmacological and antisense oligonucleotide mediated inhibition of DHFR, an integral enzyme in the folate pathway, results in specific changes in the size and shape of the midface and embryonic mouth.	Folic Acid	132-138	dihydrofolate reductase	Homo sapiens	100-104
26071411-13	2015	Folate supplementation down-regulated homocysteine-induced IL-17 and RORgammat expressions.	Folic Acid	0-6	interleukin 17A	Rattus norvegicus	59-64
24467436-8	2014	Human NAT1 is strongly expressed in oestrogen receptor-positive breast cancer and may contribute to folate and acetyl CoA homeostasis.	Folic Acid	100-106	N-acetyltransferase 1	Homo sapiens	6-10
31542479-4	2019	Here we found that the expression of dihydrofolate reductase (DHFR) and thymidylate synthetase (TYMS), which played an essential role in folate metabolism and several types of tumors, were up-regulated in both human glioma tissues and cell lines, and overexpression of DHFR/TYMS promoted the proliferation of glioma cells.	Folic Acid	44-50	dihydrofolate reductase	Homo sapiens	62-66
23920500-7	2014	Inverse associations between PAD and intakes of fiber, folate, and vitamins A, B6, C, and E were statistically significant when adjusting for age, sex, hypertension, diabetes and smoking.	Folic Acid	55-61	peptidyl arginine deiminase 4	Homo sapiens	29-32
31542479-4	2019	Here we found that the expression of dihydrofolate reductase (DHFR) and thymidylate synthetase (TYMS), which played an essential role in folate metabolism and several types of tumors, were up-regulated in both human glioma tissues and cell lines, and overexpression of DHFR/TYMS promoted the proliferation of glioma cells.	Folic Acid	44-50	thymidylate synthetase	Homo sapiens	72-94
31542479-4	2019	Here we found that the expression of dihydrofolate reductase (DHFR) and thymidylate synthetase (TYMS), which played an essential role in folate metabolism and several types of tumors, were up-regulated in both human glioma tissues and cell lines, and overexpression of DHFR/TYMS promoted the proliferation of glioma cells.	Folic Acid	44-50	thymidylate synthetase	Homo sapiens	96-100
26279693-8	2015	FR-positive tumors were clearly visualized on both scintigraphy and micro-SPECT/CT images and the tumor uptake of (99m)Tc-ECG-EDA-folate was markedly suppressed with faint visualization of tumors by pre-administration of excess free folate on serial planar scintigraphy, indicating FR-specific binding of the agent.	Folic Acid	130-136	ectodysplasin-A	Mus musculus	126-129
31542479-4	2019	Here we found that the expression of dihydrofolate reductase (DHFR) and thymidylate synthetase (TYMS), which played an essential role in folate metabolism and several types of tumors, were up-regulated in both human glioma tissues and cell lines, and overexpression of DHFR/TYMS promoted the proliferation of glioma cells.	Folic Acid	44-50	dihydrofolate reductase	Homo sapiens	269-273
24532085-12	2014	Identification of FTO rs9939609 reinforces the importance of adequate fruit, vegetable and folate and restriction of saturated/trans fat intake in the diet.	Folic Acid	91-97	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	18-21
31542479-4	2019	Here we found that the expression of dihydrofolate reductase (DHFR) and thymidylate synthetase (TYMS), which played an essential role in folate metabolism and several types of tumors, were up-regulated in both human glioma tissues and cell lines, and overexpression of DHFR/TYMS promoted the proliferation of glioma cells.	Folic Acid	44-50	thymidylate synthetase	Homo sapiens	274-278
31698794-3	2019	In this study, we successfully conjugated folate to polyethylene glycol 100 monostearate as film-forming material and further prepared methotrexate (MTX) and catalase (CAT) co-encapsulated liposomes, herein, shortened to FOL-MTX&amp;CAT-L, that could actively target to activated macrophages.	Folic Acid	42-48	cathepsin L	Mus musculus	233-238
24688052-10	2014	Collectively, we identify altered regulation of folate metabolism in KRAS-mutant NSCLC cells that may account for higher antifolate activity in this subtype of NSCLC.	Folic Acid	48-54	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	69-73
26248049-5	2015	Additional or simultaneous expression of FR-beta could help extend the indications for folate-based drugs and imaging agents.	Folic Acid	87-93	folate receptor beta	Homo sapiens	41-48
31698794-7	2019	In vitro results revealed that FOL-MTX&amp;CAT-L possessed sufficient ROS-sensitive drug release, displayed an improved cellular uptake through folate-mediated endocytosis and exhibited a higher cytotoxic effect on activated RAW264.7 cells.	Folic Acid	144-150	cathepsin L	Mus musculus	43-48
31401334-2	2019	Dihydrofolate reductase (DHFR), an enzyme involved in folate metabolism converts dihydrofolate into tetrahydrofolate, which is required for the de novo synthesis of purines, and certain amino acids.	Folic Acid	7-13	dihydrofolate reductase	Homo sapiens	25-29
25900406-3	2015	Finally, iminoboronates were used to assemble a folic acid/paclitaxel small-molecule/drug conjugate in situ with an IC50  value of 20.7 nM against NCI-H460 cancer cells and negligible cytotoxicity against the CRL-1502 noncancer cells.	Folic Acid	48-58	interleukin 31 receptor A	Homo sapiens	209-212
31593741-8	2019	Nilotinib significantly decreased folic acid-induced elevation in serum Cr, BUN, LDH and urine MTP, kidney MDA content and significantly increased folic acid-induced reduction in serum albumin, CrC, urine urea, kidney SOD activity and GSH content.	Folic Acid	34-44	metallothionein 1B	Homo sapiens	95-98
24853427-10	2014	Using folate-targeted nanoparticles to encapsulate and deliver CT20p to murine tumors, we achieved significant tumor regression within days of peptide treatment.	Folic Acid	6-12	serine protease 50	Homo sapiens	63-68
31532618-2	2019	A new pathway of folate uptake mediated by folate receptor alpha (FRalpha, molecular weight of 28.29 kg mol-1) occurring in various epithelial cells of the CNS (e.g., choroid plexus) was described.	Folic Acid	17-23	folate receptor alpha	Homo sapiens	43-64
24823794-0	2014	From arylamine N-acetyltransferase to folate-dependent acetyl CoA hydrolase: impact of folic acid on the activity of (HUMAN)NAT1 and its homologue (MOUSE)NAT2.	Folic Acid	87-97	N-acetyltransferase 1	Homo sapiens	124-128
24532667-2	2014	However, the folylpoly-gamma-glutamate synthetase (fpgs) gene, whose product determines folate/antifolate intracellular retention and antifolate antitumor activity, displays a pronounced species difference.	Folic Acid	88-94	folylpolyglutamyl synthetase	Mus musculus	13-49
25608532-0	2015	Identification of Tyr residues that enhance folate substrate binding and constrain oscillation of the proton-coupled folate transporter (PCFT-SLC46A1).	Folic Acid	44-50	solute carrier family 46 member 1	Homo sapiens	142-149
25608532-1	2015	The proton-coupled folate transporter (PCFT) mediates intestinal folate absorption and transport of folates across the choroid plexus.	Folic Acid	19-25	solute carrier family 46 member 1	Homo sapiens	39-43
25608532-1	2015	The proton-coupled folate transporter (PCFT) mediates intestinal folate absorption and transport of folates across the choroid plexus.	Folic Acid	100-107	solute carrier family 46 member 1	Homo sapiens	39-43
24532667-2	2014	However, the folylpoly-gamma-glutamate synthetase (fpgs) gene, whose product determines folate/antifolate intracellular retention and antifolate antitumor activity, displays a pronounced species difference.	Folic Acid	88-94	folylpolyglutamyl synthetase	Mus musculus	51-55
31532618-2	2019	A new pathway of folate uptake mediated by folate receptor alpha (FRalpha, molecular weight of 28.29 kg mol-1) occurring in various epithelial cells of the CNS (e.g., choroid plexus) was described.	Folic Acid	17-23	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	66-73
31532618-11	2019	In both cases, NPs surface-modified with the FRalpha and complexed to folic acid (FA) showed significantly higher apparent permeability coefficient (Papp) values than the pristine ones.	Folic Acid	70-80	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	45-52
25564455-1	2015	Folate can be transported into the cell by the reduced folate carrier (RFC), the proton-coupled folate transporter (PCFT), or the folate receptor (FR), of which various isoforms exist.	Folic Acid	0-6	solute carrier family 46 member 1	Homo sapiens	81-114
25564455-1	2015	Folate can be transported into the cell by the reduced folate carrier (RFC), the proton-coupled folate transporter (PCFT), or the folate receptor (FR), of which various isoforms exist.	Folic Acid	0-6	solute carrier family 46 member 1	Homo sapiens	116-120
31581752-4	2019	Normal levels of folates in the blood are maintained not only by proper dietary intake and intestinal absorption, but also by an efficient renal reabsorption that seems to be primarily mediated by the glycosylphosphatidylinositol- (GPI) anchored protein folate receptor alpha (FRalpha), which is highly expressed at the brush-border membrane of proximal tubule cells.	Folic Acid	17-24	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	277-284
24399840-1	2014	Vitamin B9, commonly known as folate, is an essential cofactor for one-carbon metabolism that enters cells through three major specialized transporter molecules (RFC, FR, and PCFT), which differ in expression pattern, affinity for substrate, and ligand-binding pH dependency.	Folic Acid	0-10	solute carrier family 46 member 1	Homo sapiens	175-179
24399840-1	2014	Vitamin B9, commonly known as folate, is an essential cofactor for one-carbon metabolism that enters cells through three major specialized transporter molecules (RFC, FR, and PCFT), which differ in expression pattern, affinity for substrate, and ligand-binding pH dependency.	Folic Acid	30-36	solute carrier family 46 member 1	Homo sapiens	175-179
31366217-5	2019	Hyperhomocysteinemia potentiated T2DM-induced mononuclear cell, monocyte, inflammatory monocyte (CD11b+Ly6C+), and M1 macrophage differentiation in periphery and aorta, which were rescued by folic acid-based homocysteine-lowering therapy.	Folic Acid	191-201	lymphocyte antigen 6 complex, locus C1	Mus musculus	103-107
24396145-4	2014	PCFT mediates the intestinal absorption of dietary folates and appears to be important for transport of folates into the central nervous system.	Folic Acid	51-58	solute carrier family 46 member 1	Homo sapiens	0-4
24396145-4	2014	PCFT mediates the intestinal absorption of dietary folates and appears to be important for transport of folates into the central nervous system.	Folic Acid	104-111	solute carrier family 46 member 1	Homo sapiens	0-4
25677305-3	2015	In this study, 13 folate analogues under clinical evaluation or in therapeutic use were in silico screened against SHMT, ultimately identifying four antifolate agents worthy of closer evaluation.	Folic Acid	18-24	serine hydroxymethyltransferase 1	Homo sapiens	115-119
31209892-4	2019	Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2), a mitochondrial enzyme involved in folic acid metabolism, interestingly was confirmed to be one of the target genes of miR-33a-5p in the present study.	Folic Acid	87-97	microRNA 33a	Homo sapiens	171-178
26264706-1	2015	Folic acid (FA) has high affinity to folate receptors (FRs), which have three isoforms: FRalpha, FRbeta and FRgamma.	Folic Acid	0-10	folate receptor alpha	Bos taurus	88-95
25009037-7	2014	Results from interaction analysis showed that serum folate deficiency had an additive interaction with HPV16 infection in CIN II/III and SCC, while RBC folate having an additive interaction with HPV16 infection in the whole process of cervix cancerization.	Folic Acid	52-58	serpin family B member 3	Homo sapiens	137-140
24446917-4	2014	The present study quantitates the number of cell surface FR-alpha and FR-beta following exposure to saturating concentrations of a variety of folate-linked molecules and anti-FR antibodies, including the unmodified vitamin, folate-linked drug mimetics, multifolate derivatized nanoparticles, and monoclonal antibodies to FR.	Folic Acid	142-148	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	57-65
24446917-4	2014	The present study quantitates the number of cell surface FR-alpha and FR-beta following exposure to saturating concentrations of a variety of folate-linked molecules and anti-FR antibodies, including the unmodified vitamin, folate-linked drug mimetics, multifolate derivatized nanoparticles, and monoclonal antibodies to FR.	Folic Acid	142-148	folate receptor beta	Homo sapiens	70-77
31356752-2	2019	Two requisites for response to a folate-based SMDC are (i) folate receptor alpha (FRalpha) protein is expressed in the diseased tissues, and (ii) FRalpha in those tissues is accessible and functionally competent to bind systemically administered SMDCs.	Folic Acid	33-39	folate receptor alpha	Homo sapiens	59-80
24374293-7	2014	Stable holo-FBP multimers may protect naturally occurring labile folates against decomposition or bacterial utilization.	Folic Acid	65-72	folate receptor alpha	Homo sapiens	12-15
24374293-12	2014	Fluorescence spectroscopy after irreversible thermal unfolding of FBP revealed a weak-affinity folate binding.	Folic Acid	95-101	folate receptor alpha	Homo sapiens	66-69
31356752-2	2019	Two requisites for response to a folate-based SMDC are (i) folate receptor alpha (FRalpha) protein is expressed in the diseased tissues, and (ii) FRalpha in those tissues is accessible and functionally competent to bind systemically administered SMDCs.	Folic Acid	33-39	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	82-89
31356752-2	2019	Two requisites for response to a folate-based SMDC are (i) folate receptor alpha (FRalpha) protein is expressed in the diseased tissues, and (ii) FRalpha in those tissues is accessible and functionally competent to bind systemically administered SMDCs.	Folic Acid	33-39	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	146-153
31356752-4	2019	Data show that EC2220 produces a far greater IHC signal in FRalpha-positive tissues over that produced with EC17, a folate-fluorescein SMRC that is released from the formaldehyde-denatured FRalpha protein.	Folic Acid	116-122	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	189-196
31405972-0	2019	Upregulation of reduced folate carrier by vitamin D enhances brain folate uptake in mice lacking folate receptor alpha.	Folic Acid	24-30	folate receptor 1 (adult)	Mus musculus	97-118
24556562-1	2014	Loss-of-function mutations in the FOLR1 gene (MIM *136430), encoding the folate receptor alpha, impair cerebral folate transport and lead to a progressive neurometabolic disorder.	Folic Acid	73-79	folate receptor alpha	Homo sapiens	34-39
24556396-3	2014	The semi-invariant MAIT T-cell antigen receptor (TCR) recognises riboflavin and folic acid metabolites bound by MR1 in a conserved docking mode, and thus acts like a pattern recognition receptor.	Folic Acid	80-90	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	24-47
31405972-2	2019	Folate transport is mediated by 3 major pathways, reduced folate carrier (RFC), proton-coupled folate transporter (PCFT), and folate receptor alpha (FRalpha/Folr1), known to be regulated by ligand-activated nuclear receptors.	Folic Acid	0-6	folate receptor 1 (adult)	Mus musculus	126-147
24556396-3	2014	The semi-invariant MAIT T-cell antigen receptor (TCR) recognises riboflavin and folic acid metabolites bound by MR1 in a conserved docking mode, and thus acts like a pattern recognition receptor.	Folic Acid	80-90	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	49-52
31405972-2	2019	Folate transport is mediated by 3 major pathways, reduced folate carrier (RFC), proton-coupled folate transporter (PCFT), and folate receptor alpha (FRalpha/Folr1), known to be regulated by ligand-activated nuclear receptors.	Folic Acid	0-6	folate receptor 1 (adult)	Mus musculus	157-162
31405972-8	2019	These findings demonstrate that augmenting RFC functional expression at the BBB could effectively compensate for the loss of Folr1-mediated folate uptake at the choroid plexus, providing a therapeutic approach for neurometabolic disorders caused by defective brain folate transport.	Folic Acid	140-146	folate receptor 1 (adult)	Mus musculus	125-130
24362509-0	2014	DNMT3B C46359T and SHMT1 C1420T polymorphisms in the folate pathway in carcinogenesis of head and neck.	Folic Acid	53-59	DNA methyltransferase 3 beta	Homo sapiens	0-6
31405972-8	2019	These findings demonstrate that augmenting RFC functional expression at the BBB could effectively compensate for the loss of Folr1-mediated folate uptake at the choroid plexus, providing a therapeutic approach for neurometabolic disorders caused by defective brain folate transport.	Folic Acid	265-271	folate receptor 1 (adult)	Mus musculus	125-130
24362509-0	2014	DNMT3B C46359T and SHMT1 C1420T polymorphisms in the folate pathway in carcinogenesis of head and neck.	Folic Acid	53-59	serine hydroxymethyltransferase 1	Homo sapiens	19-24
24362509-3	2014	We investigated DNMT3B C46359T (rs2424913) and SHMT1 C1420T (rs1979277) polymorphisms related to folate pathway in head and neck cancer (HNC) risk and the association of the disease with gender, risk factors and clinical histopathological parameters.	Folic Acid	97-103	DNA methyltransferase 3 beta	Homo sapiens	16-22
31443485-11	2019	The opposite effect DHFR promoter variant has in tuning ALL onset-time depending on who is the carrier (i.e., mother or child) might suggest a parent-origin-effect of the D-allele or a two-faced epigenetic role driven by unbalanced folate isoform availability during the in-utero leukemogenesis responsible for the wide postnatal childhood ALL latency.	Folic Acid	232-238	dihydrofolate reductase	Homo sapiens	20-24
24362509-3	2014	We investigated DNMT3B C46359T (rs2424913) and SHMT1 C1420T (rs1979277) polymorphisms related to folate pathway in head and neck cancer (HNC) risk and the association of the disease with gender, risk factors and clinical histopathological parameters.	Folic Acid	97-103	serine hydroxymethyltransferase 1	Homo sapiens	47-52
31467993-5	2019	Decreased MBD2 and MECP2 were discovered upon treatment of SHSY5Y cells with a 2x folic acid dose.	Folic Acid	82-92	methyl-CpG binding domain protein 2	Homo sapiens	10-14
27025730-10	2014	These inhibitors are also likely to interact with the enzymatic neighbors in the folate pathway that bind products of the DHFR or DHPS enzymes and/or substrates of similar substructure.	Folic Acid	81-87	dihydrofolate reductase	Homo sapiens	122-126
31165884-8	2019	RESULTS: The categorical model resulted in 6 DMPs, which are all negatively associated with folate intake, annotated to FAM64A, WRAP73, FRMD8, CUX1, and LCN8 genes, which have a role in cellular processes including centrosome localization, cell proliferation, and tumorigenesis.	Folic Acid	92-98	lipocalin 8	Homo sapiens	153-157
24465421-13	2014	Folic acid supplementation was also associated with an increased expression of BAX, PARP, and HER2.	Folic Acid	0-10	BCL2 associated X, apoptosis regulator	Rattus norvegicus	79-82
24294939-8	2014	The absorptive flux (apical to basolateral) of folic acid was enhanced by EPO treatment in a dose-dependent manner, which was companied with the significant up-regulation of reduced folate carrier (RFC) and apical proton coupled folate transporter (PCFT).	Folic Acid	47-57	solute carrier family 46 member 1	Homo sapiens	214-247
31165884-10	2019	The most significant folate-associated DMR was a 400-base pair (bp) spanning region annotated to the LGALS3BP gene.	Folic Acid	21-27	galectin 3 binding protein	Homo sapiens	101-109
24294939-8	2014	The absorptive flux (apical to basolateral) of folic acid was enhanced by EPO treatment in a dose-dependent manner, which was companied with the significant up-regulation of reduced folate carrier (RFC) and apical proton coupled folate transporter (PCFT).	Folic Acid	47-57	solute carrier family 46 member 1	Homo sapiens	249-253
31353838-10	2019	Preoperative supplementation with VB12 and folic acid (FA) in the diet or S-adenosylmethionine (SAM) injection reduced perioperative serum Hcy level and inhibited the development of PND in aged mice.	Folic Acid	43-53	natriuretic peptide type A	Mus musculus	182-185
25081683-1	2014	Folate receptor alpha (FRalpha) mediates folate uptake by endocytosis, and while folate is essential to DNA methylation and synthesis and may have an important role in proliferating cells.	Folic Acid	41-47	folate receptor alpha	Homo sapiens	0-21
25081683-1	2014	Folate receptor alpha (FRalpha) mediates folate uptake by endocytosis, and while folate is essential to DNA methylation and synthesis and may have an important role in proliferating cells.	Folic Acid	41-47	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	23-30
31167838-5	2019	The positive controls, methotrexate and pemetrexed, demonstrated clinically relevant inhibition of PCFT, RFC, and FRalpha in folate absorption, distribution, and renal sparing.	Folic Acid	125-131	solute carrier family 46 member 1	Homo sapiens	99-103
31167838-5	2019	The positive controls, methotrexate and pemetrexed, demonstrated clinically relevant inhibition of PCFT, RFC, and FRalpha in folate absorption, distribution, and renal sparing.	Folic Acid	125-131	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	114-121
31064276-6	2019	The obtained folate-modified cells successfully adhered on to target cells which expressed folate receptor alpha via ligand-receptor specific interaction and adhesion continued at least 4 hours.	Folic Acid	13-19	folate receptor alpha	Homo sapiens	91-112
25003120-7	2014	Results suggest that maternal micronutrient imbalance (excess folic acid with vitamin B12 deficiency) leads to lower mRNA levels of methylene tetrahydrofolate reductase (MTHFR) and methionine synthase , but higher cystathionine b-synthase (CBS) and Phosphatidylethanolamine-N-methyltransferase (PEMT) as compared to control.	Folic Acid	62-72	methylenetetrahydrofolate reductase	Rattus norvegicus	132-168
25003120-7	2014	Results suggest that maternal micronutrient imbalance (excess folic acid with vitamin B12 deficiency) leads to lower mRNA levels of methylene tetrahydrofolate reductase (MTHFR) and methionine synthase , but higher cystathionine b-synthase (CBS) and Phosphatidylethanolamine-N-methyltransferase (PEMT) as compared to control.	Folic Acid	62-72	methylenetetrahydrofolate reductase	Rattus norvegicus	170-175
31241900-5	2019	Complementary spectroscopic techniques such as ROESY-NMR, UV/vis and steady-state fluorescence revealed that the folic acid protrudes out of amphiphilic CD rims, prone for recognition with FR-alpha.	Folic Acid	113-123	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	189-197
24622812-4	2014	In this study, we determined the presence of FR-beta-expressing macrophages in atherosclerotic lesions by the use of a fluorine-18-labeled folate-based radiotracer.	Folic Acid	139-145	folate receptor beta	Homo sapiens	45-52
24622812-13	2014	Selectively targeting FR-beta-positive macrophages through folate-based radiopharmaceuticals may be useful for noninvasive imaging of plaque inflammation.	Folic Acid	59-65	folate receptor beta	Homo sapiens	22-29
31123954-1	2019	PURPOSE: Vitamin B12 (cobalamin, Cbl) plays a role in the recycling of folate, which is important in pregnancy.	Folic Acid	71-77	Cbl proto-oncogene	Homo sapiens	33-36
31087489-0	2019	Folic acid deficiency enhanced microglial immune response via the Notch1/nuclear factor kappa B p65 pathway in hippocampus following rat brain I/R injury and BV2 cells.	Folic Acid	0-10	notch receptor 1	Rattus norvegicus	66-95
24383099-1	2013	Recent studies have identified the proton-coupled folate transporter (PCFT) as the mechanism by which folates are absorbed across the apical brush-border membrane of the small intestine and across the basolateral membrane of the choroid plexus into the cerebrospinal fluid.	Folic Acid	102-109	solute carrier family 46 member 1	Homo sapiens	70-74
24383099-4	2013	PCFT has a spectrum of affinities for folates and antifolates that narrows and increases at low pH.	Folic Acid	38-45	solute carrier family 46 member 1	Homo sapiens	0-4
23820268-8	2013	NOS recoupling using folic acid reversed insulin resistance-induced changes in NO and ONOO(-), CaMKII phosphorylation, and cardiac mechanical abnormalities.	Folic Acid	21-31	calcium/calmodulin-dependent protein kinase II gamma	Mus musculus	95-101
23820268-9	2013	Taken together, these data demonstrated that treatment with folic acid may reverse cardiac contractile and intracellular Ca(2+) anomalies through ablation of CaMKII phosphorylation and RYR Ca(2+) leak.	Folic Acid	60-70	calcium/calmodulin-dependent protein kinase II gamma	Mus musculus	158-164
30693532-8	2019	It also provides a description of folate-mediated one-carbon metabolism and its intersection with Cbl at the methionine cycle.	Folic Acid	34-40	Cbl proto-oncogene	Homo sapiens	98-101
23973753-1	2013	Folic acid (FA), also named vitamin B9, is an essential cofactor for the synthesis of DNA bases and other biomolecules after bioactivation by dihydrofolate reductase (DHFR).	Folic Acid	0-10	dihydrofolate reductase	Homo sapiens	142-165
23973753-1	2013	Folic acid (FA), also named vitamin B9, is an essential cofactor for the synthesis of DNA bases and other biomolecules after bioactivation by dihydrofolate reductase (DHFR).	Folic Acid	0-10	dihydrofolate reductase	Homo sapiens	167-171
23973753-1	2013	Folic acid (FA), also named vitamin B9, is an essential cofactor for the synthesis of DNA bases and other biomolecules after bioactivation by dihydrofolate reductase (DHFR).	Folic Acid	28-38	dihydrofolate reductase	Homo sapiens	142-165
23973753-1	2013	Folic acid (FA), also named vitamin B9, is an essential cofactor for the synthesis of DNA bases and other biomolecules after bioactivation by dihydrofolate reductase (DHFR).	Folic Acid	28-38	dihydrofolate reductase	Homo sapiens	167-171
25502219-1	2015	gamma-Glutamyl hydrolase (GGH) plays an important role in folate homeostasis by catalyzing hydrolysis of polyglutamylated folate into monoglutamates.	Folic Acid	58-64	gamma-glutamyl hydrolase	Homo sapiens	0-24
31537248-13	2019	The level of DNMT1 mRNA significantly increased only in the folic acid treatment group, and the levels of DNMT1, DNMT3a and DNMT3b were not significantly changed.	Folic Acid	60-70	DNA methyltransferase 1	Rattus norvegicus	13-18
25502219-1	2015	gamma-Glutamyl hydrolase (GGH) plays an important role in folate homeostasis by catalyzing hydrolysis of polyglutamylated folate into monoglutamates.	Folic Acid	58-64	gamma-glutamyl hydrolase	Homo sapiens	26-29
25502219-1	2015	gamma-Glutamyl hydrolase (GGH) plays an important role in folate homeostasis by catalyzing hydrolysis of polyglutamylated folate into monoglutamates.	Folic Acid	122-128	gamma-glutamyl hydrolase	Homo sapiens	0-24
25502219-1	2015	gamma-Glutamyl hydrolase (GGH) plays an important role in folate homeostasis by catalyzing hydrolysis of polyglutamylated folate into monoglutamates.	Folic Acid	122-128	gamma-glutamyl hydrolase	Homo sapiens	26-29
25502219-8	2015	Our data suggest that the GGH modulation-induced changes in total intracellular folate concentrations and content of long-chain folylpolyglutamates are associated with functionally significant DNA methylation alterations in several important biological pathways.	Folic Acid	80-86	gamma-glutamyl hydrolase	Homo sapiens	26-29
22147344-8	2013	SHMT and TYMS variants were found to decrease oxidative stress by increasing the folate pool (r = 0.38, P = 0.003) and also by increasing the antioxidant status (r = 0.28, P = 0.03).	Folic Acid	81-87	serine hydroxymethyltransferase 1	Homo sapiens	0-4
22147344-8	2013	SHMT and TYMS variants were found to decrease oxidative stress by increasing the folate pool (r = 0.38, P = 0.003) and also by increasing the antioxidant status (r = 0.28, P = 0.03).	Folic Acid	81-87	thymidylate synthetase	Homo sapiens	9-13
31171577-8	2019	Strikingly, the anterior cleft palate in Cbfb mutants is further rescued by pharmaceutical application of folic acid, which activates suppressed Stat3 phosphorylation and Tgfb3 expression in vitro With these findings, we provide the first evidence that Cbfb is a prerequisite for anterior palatogenesis and acts as an obligatory cofactor in the Runx1/Cbfb-Stat3-Tgfb3 signaling axis.	Folic Acid	106-116	transforming growth factor, beta 3	Mus musculus	171-176
31171577-8	2019	Strikingly, the anterior cleft palate in Cbfb mutants is further rescued by pharmaceutical application of folic acid, which activates suppressed Stat3 phosphorylation and Tgfb3 expression in vitro With these findings, we provide the first evidence that Cbfb is a prerequisite for anterior palatogenesis and acts as an obligatory cofactor in the Runx1/Cbfb-Stat3-Tgfb3 signaling axis.	Folic Acid	106-116	transforming growth factor, beta 3	Mus musculus	362-367
31494266-7	2019	Moreover, significant genetic diversity in MTHFR, TCN2, FADS1, and FADS2, which associate with circulating folate, vitamin B12, or lipid metabolism, was observed between northerners and southerners.	Folic Acid	107-113	fatty acid desaturase 1	Homo sapiens	56-61
24025360-3	2013	The human folate receptor alpha (FOLR1), which is overexpressed in ovarian cancer but largely absent in normal tissues, appears to play a role in the transformed phenotype in ovarian cancer, cisplatin sensitivity, and growth in depleted folate conditions and therefore has potential as a target for passive immunotherapy.	Folic Acid	10-16	folate receptor alpha	Homo sapiens	33-38
26875486-2	2015	Dihydrofolate reductase (DHFR) is critical in the metabolism of synthetic folic acid (pteroylmonoglutamatamic, PteGlu) to tetrahydrofolate following absorption.	Folic Acid	74-84	dihydrofolate reductase	Homo sapiens	0-23
26875486-2	2015	Dihydrofolate reductase (DHFR) is critical in the metabolism of synthetic folic acid (pteroylmonoglutamatamic, PteGlu) to tetrahydrofolate following absorption.	Folic Acid	74-84	dihydrofolate reductase	Homo sapiens	25-29
30941645-9	2019	In NTDs, there was an adaptive up-regulation of folate transporters mainly reduced folate carrier (p &lt; 0.001) and folate receptor alpha (p &lt; 0.001).	Folic Acid	48-54	folate receptor alpha	Homo sapiens	117-138
26875486-2	2015	Dihydrofolate reductase (DHFR) is critical in the metabolism of synthetic folic acid (pteroylmonoglutamatamic, PteGlu) to tetrahydrofolate following absorption.	Folic Acid	111-117	dihydrofolate reductase	Homo sapiens	0-23
26875486-2	2015	Dihydrofolate reductase (DHFR) is critical in the metabolism of synthetic folic acid (pteroylmonoglutamatamic, PteGlu) to tetrahydrofolate following absorption.	Folic Acid	111-117	dihydrofolate reductase	Homo sapiens	25-29
26875486-3	2015	Therefore, the 19bp deletion variant of DHFR may lead to the alteration of folate-related colorectal disease susceptibility.	Folic Acid	75-81	dihydrofolate reductase	Homo sapiens	40-44
24168269-1	2013	BACKGROUND: Folypolyglutamate synthase (FPGS) catalyzes the polyglutamation of folates and antifolates, such as methotrexate (MTX), to produce highly active metabolites.	Folic Acid	79-86	folylpolyglutamate synthase	Homo sapiens	12-38
24168269-1	2013	BACKGROUND: Folypolyglutamate synthase (FPGS) catalyzes the polyglutamation of folates and antifolates, such as methotrexate (MTX), to produce highly active metabolites.	Folic Acid	79-86	folylpolyglutamate synthase	Homo sapiens	40-44
31100893-7	2019	An excess of free folate as the competitor for the FRalpha-mediated uptake inhibits the phototoxicity.	Folic Acid	18-24	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	51-58
24045662-4	2013	RESULTS: Overexpression of GGH significantly decreased chemosensitivity of MDA-MB-435 cells to 5FU and MTX at all folate concentrations as expected.	Folic Acid	114-120	gamma-glutamyl hydrolase	Homo sapiens	27-30
24045662-7	2013	Inhibition of GGH significantly increased chemosensitivity of both cancer cells to 5FU at all folate concentrations.	Folic Acid	94-100	gamma-glutamyl hydrolase	Homo sapiens	14-17
25245820-2	2015	Thymidylate (dTMP) is catalyzed by thymidylate synthase (TS) using the folate-derived one-carbon unit as the sole methyl donor.	Folic Acid	71-77	thymidylate synthetase	Homo sapiens	35-55
24045662-8	2013	Unexpectedly, GGH inhibition significantly decreased chemosensitivity of both cancer cells to MTX at all folate concentrations.	Folic Acid	105-111	gamma-glutamyl hydrolase	Homo sapiens	14-17
24045662-9	2013	In both GGH modulation systems and cell lines, the magnitude of chemosensitivity effect incrementally increased as folate concentration increased.	Folic Acid	115-121	gamma-glutamyl hydrolase	Homo sapiens	8-11
30870638-0	2019	Highly sensitive and specific cytosensing of HT 29 colorectal cancer cells using folic acid functionalized-KCC-1 nanoparticles.	Folic Acid	81-91	solute carrier family 12 member 4	Homo sapiens	107-112
23893618-7	2013	Two TYMS SNPs (rs16948305 and rs495139) exhibited significant (P = 0.024 and P = 0.040, respectively) gene-diet interactions with folate intake.	Folic Acid	130-136	thymidylate synthetase	Homo sapiens	4-8
23904512-2	2013	Folates are generally taken up into cells by specific transporters, mainly the reduced folate carrier RFC1 (SLC19A1 protein) and the high-affinity folate receptors FOLR1 and FOLR2.	Folic Acid	0-7	folate receptor 1 (adult)	Mus musculus	164-169
32261799-6	2014	With the further conjugation of folic acid, the Gd:CdTe QDs can successfully label live HepG2 cells for targeted cellular imaging and present no evidence of cellular toxicity up to the concentration of 0.5 mg mL-1.	Folic Acid	32-42	L1 cell adhesion molecule	Mus musculus	209-213
30870638-1	2019	Functionalized fibrous nano-silica (KCC-1) was applied to specific electrochemical detection of HT 29 colorectal cancer cells based on folate (FA)/folate receptor (FR) interactions.	Folic Acid	135-141	solute carrier family 12 member 4	Homo sapiens	36-41
31024236-0	2019	Excess Folic Acid Supplementation Before and During Pregnancy and Lactation Activates Fos Gene Expression and Alters Behaviors in Male Mouse Offspring.	Folic Acid	7-17	FBJ osteosarcoma oncogene	Mus musculus	86-89
24891518-0	2014	Genome-wide DNA methylation profiling identifies a folate-sensitive region of differential methylation upstream of ZFP57-imprinting regulator in humans.	Folic Acid	51-57	ZFP57 zinc finger protein	Homo sapiens	115-120
23400770-0	2013	Folate usage in MTX-treated juvenile idiopathic arthritis (JIA) patients is inconsistent and highly variable.	Folic Acid	0-6	metaxin 1	Homo sapiens	16-19
30409571-3	2019	The structure of native folates contains polyglutamyl chains, which reportedly jeopardize the bioavailability of native folates; further gamma-glutamyl hydrolase (GGH) can deglutamylate polyglutamyl chains.	Folic Acid	24-31	gamma-glutamyl hydrolase	Homo sapiens	137-161
23851396-4	2013	To understand how folate binds its receptors, we determined the crystal structure of human FRalpha in complex with folic acid at 2.8 A resolution.	Folic Acid	18-24	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	91-98
23851396-4	2013	To understand how folate binds its receptors, we determined the crystal structure of human FRalpha in complex with folic acid at 2.8 A resolution.	Folic Acid	115-125	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	91-98
23851396-5	2013	FRalpha has a globular structure stabilized by eight disulphide bonds and contains a deep open folate-binding pocket comprised of residues that are conserved in all receptor subtypes.	Folic Acid	95-101	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	0-7
25177862-2	2014	In the present study, paclitaxel (PTX) and DNA were co-loaded in the hyaluronic acid (HA) and folate (FA)-modified liposomes (HA/FA/PPD), to obtain the dual targeting biomimetic nanovector.	Folic Acid	94-100	cellular communication network factor 6	Homo sapiens	126-135
25232375-9	2014	DNMT1 and DNMT3a mRNA level were elevated (P &lt; 0.05) in AD patients and folate deficient medium cultured cells compared with controls (P &lt; 0.05), together with lower folate concentration in AD.	Folic Acid	75-81	DNA methyltransferase 3 alpha	Homo sapiens	10-16
23424995-8	2013	KEY RESULTS: Folate up-regulated p21/p27 through a Src/ERK-dependent mechanism that accounted for its anti-proliferative effects on RASMC.	Folic Acid	13-19	cyclin-dependent kinase inhibitor 1B	Rattus norvegicus	37-40
30409571-3	2019	The structure of native folates contains polyglutamyl chains, which reportedly jeopardize the bioavailability of native folates; further gamma-glutamyl hydrolase (GGH) can deglutamylate polyglutamyl chains.	Folic Acid	24-31	gamma-glutamyl hydrolase	Homo sapiens	163-166
23424995-9	2013	Folate protected RASMC from the effects of homocysteine by reducing AKT1, focal adhesion kinase (FAK), paxillin, and p190RhoGAP activation/phosphorylation, along with cytosolic levels of p21 and p27, and increasing RhoA activation.	Folic Acid	0-6	protein tyrosine kinase 2	Rattus norvegicus	74-95
23424995-9	2013	Folate protected RASMC from the effects of homocysteine by reducing AKT1, focal adhesion kinase (FAK), paxillin, and p190RhoGAP activation/phosphorylation, along with cytosolic levels of p21 and p27, and increasing RhoA activation.	Folic Acid	0-6	protein tyrosine kinase 2	Rattus norvegicus	97-100
30409571-7	2019	Pure human recombinant GGH with a higher catalytic efficiency and stable enzymatic properties was better than traditional folate conjugase for this purpose.	Folic Acid	122-128	gamma-glutamyl hydrolase	Homo sapiens	23-26
23424995-9	2013	Folate protected RASMC from the effects of homocysteine by reducing AKT1, focal adhesion kinase (FAK), paxillin, and p190RhoGAP activation/phosphorylation, along with cytosolic levels of p21 and p27, and increasing RhoA activation.	Folic Acid	0-6	cyclin-dependent kinase inhibitor 1B	Rattus norvegicus	195-198
24712521-3	2014	We investigated the influence of single nucleotide polymorphisms (SNPs) in genes of the folate metabolic pathway, transporter molecules and transcription proteins on the pharmacokinetics and toxicity of MTX and 7-hydroxy-methotrexate (7-OH-MTX).	Folic Acid	88-94	metaxin 1	Homo sapiens	203-206
30409571-11	2019	Further, this is the first study to show the application of recombinant pure GGH for the deconjugation of polyglutamyl folates for folate vitamers and total folates analysis.	Folic Acid	119-125	gamma-glutamyl hydrolase	Homo sapiens	77-80
30409571-11	2019	Further, this is the first study to show the application of recombinant pure GGH for the deconjugation of polyglutamyl folates for folate vitamers and total folates analysis.	Folic Acid	119-126	gamma-glutamyl hydrolase	Homo sapiens	77-80
30867454-1	2019	In folate-mediated one-carbon metabolism (FOCM), 5-formyltetrahydrofolate (5fTHF), a one-carbon substituted tetrahydrofolate (THF) vitamer, acts as an intracellular storage form of folate and as an inhibitor of the folate-dependent enzymes phosphoribosylaminoimidazolecarboxamide formyltransferase (AICARFT) and serine hydroxymethyltransferase (SHMT).	Folic Acid	67-73	serine hydroxymethyltransferase 1	Homo sapiens	312-343
30867454-1	2019	In folate-mediated one-carbon metabolism (FOCM), 5-formyltetrahydrofolate (5fTHF), a one-carbon substituted tetrahydrofolate (THF) vitamer, acts as an intracellular storage form of folate and as an inhibitor of the folate-dependent enzymes phosphoribosylaminoimidazolecarboxamide formyltransferase (AICARFT) and serine hydroxymethyltransferase (SHMT).	Folic Acid	67-73	serine hydroxymethyltransferase 1	Homo sapiens	345-349
24874916-6	2014	DNA methylation at the PLAGL1, SGCE, DLK1/MEG3 and IGF2/H19 DMRs was associated with maternal folate levels and also birth weight, suggestive of threshold effects.	Folic Acid	94-100	maternally expressed 3	Homo sapiens	42-46
23702887-2	2013	This study investigates the association between levels of serum folate and prostate-specific antigen (PSA), a biomarker for prostate cancer detection.	Folic Acid	64-70	kallikrein related peptidase 3	Homo sapiens	75-106
24874916-6	2014	DNA methylation at the PLAGL1, SGCE, DLK1/MEG3 and IGF2/H19 DMRs was associated with maternal folate levels and also birth weight, suggestive of threshold effects.	Folic Acid	94-100	insulin like growth factor 2	Homo sapiens	51-55
24874916-7	2014	MEG3 DMR methylation mediated the association between maternal folate levels and birth weight (P =0.06).	Folic Acid	63-69	maternally expressed 3	Homo sapiens	0-4
23702887-7	2013	Association between serum folate and PSA levels were evaluated by multivariate linear and logistic regressions.	Folic Acid	26-32	kallikrein related peptidase 3	Homo sapiens	37-40
23702887-10	2013	CONCLUSIONS: Results of this study suggest that higher folate status may be protective against elevated PSA levels among men without diagnosed prostate cancer.	Folic Acid	55-61	kallikrein related peptidase 3	Homo sapiens	104-107
23562047-0	2013	Targeting CCL21-folic acid-upconversion nanoparticles conjugates to folate receptor-alpha expressing tumor cells in an endothelial-tumor cell bilayer model.	Folic Acid	16-26	folate receptor alpha	Homo sapiens	68-89
30867454-1	2019	In folate-mediated one-carbon metabolism (FOCM), 5-formyltetrahydrofolate (5fTHF), a one-carbon substituted tetrahydrofolate (THF) vitamer, acts as an intracellular storage form of folate and as an inhibitor of the folate-dependent enzymes phosphoribosylaminoimidazolecarboxamide formyltransferase (AICARFT) and serine hydroxymethyltransferase (SHMT).	Folic Acid	67-73	serine hydroxymethyltransferase 1	Homo sapiens	312-343
30867454-1	2019	In folate-mediated one-carbon metabolism (FOCM), 5-formyltetrahydrofolate (5fTHF), a one-carbon substituted tetrahydrofolate (THF) vitamer, acts as an intracellular storage form of folate and as an inhibitor of the folate-dependent enzymes phosphoribosylaminoimidazolecarboxamide formyltransferase (AICARFT) and serine hydroxymethyltransferase (SHMT).	Folic Acid	67-73	serine hydroxymethyltransferase 1	Homo sapiens	345-349
30411815-1	2019	BACKGROUND: Serine hydroxymethyltransferase 1 (SHMT1) is an enzyme involved in folic acid metabolism and is known to contribute to the development of hypertension.	Folic Acid	79-89	serine hydroxymethyltransferase 1	Homo sapiens	12-45
23880302-5	2013	After the selection of the best model, a folic acid molecule was docked "in silico" onto the putative binding site and its binding mode was compared with that of vintafolide, a much larger molecule designed as a chemotherapy agent targeting specifically FRalpha.	Folic Acid	41-51	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	254-261
23880302-6	2013	In both cases, a 40ns molecular dynamics trajectory was calculated, providing suggestions regarding the key structural determinants driving the affinity and specificity of FRalpha for folic acid with respect to other folate homologues.	Folic Acid	184-194	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	172-179
23880302-6	2013	In both cases, a 40ns molecular dynamics trajectory was calculated, providing suggestions regarding the key structural determinants driving the affinity and specificity of FRalpha for folic acid with respect to other folate homologues.	Folic Acid	217-223	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	172-179
24448885-2	2014	We hypothesized that tumor infiltrating inflammatory cells expressing FR-beta could allow fluorescent visualization of HNSCC tumors using folate conjugated dyes even when FR expression in cancer cells is low.	Folic Acid	138-144	folate receptor beta	Homo sapiens	70-77
24448885-12	2014	Folate conjugated fluorescent dye is able to specifically target and label tumor xenografts to permit macroscopic fluorescence imaging due to FR-beta expression on the infiltrating inflammatory cells.	Folic Acid	0-6	folate receptor beta	Homo sapiens	142-149
30411815-1	2019	BACKGROUND: Serine hydroxymethyltransferase 1 (SHMT1) is an enzyme involved in folic acid metabolism and is known to contribute to the development of hypertension.	Folic Acid	79-89	serine hydroxymethyltransferase 1	Homo sapiens	47-52
24771227-3	2014	The aim of this study was to investigate whether the genetic polymorphisms MTHFR C677T and A1298C, MTR A2756G, TYMS 2R/3R and SLC19A1 G80A, involved in folate metabolism, increase the risk of neuroblastoma in Brazilian children.	Folic Acid	152-158	thymidylate synthetase	Homo sapiens	111-115
23609145-1	2013	The proton-coupled folate transporter (PCFT) plays a key role in intestinal folate absorption, and loss-of-function mutations in the gene encoding this transporter are the molecular basis for hereditary folate malabsorption.	Folic Acid	19-25	solute carrier family 46 member 1	Homo sapiens	39-43
31058257-3	2019	Here we show that any one of these routes can support cell growth, but the oxPPP is uniquely required to maintain a normal NADPH/NADP ratio, mammalian dihydrofolate reductase (DHFR) activity and folate metabolism.	Folic Acid	158-164	dihydrofolate reductase	Homo sapiens	176-180
23552564-6	2013	The effects of 2 of these compounds were mostly reversed by folic acid, validating DHFR inhibitory activity.	Folic Acid	60-70	dihydrofolate reductase	Homo sapiens	83-87
25221392-4	2014	We hypothesize that the polymorphisms in ABCB1, Cyp2C9, Cyp2C19 and methylene tetrahydrofolate reductase (MTHFR) might result in differential expression resulting in differential drug transport, drug metabolism and folate metabolism, which in turn may contribute to the teratogenic impact of AEDs.	Folic Acid	88-94	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	48-54
31058257-6	2019	But the high NADP inhibits dihydrofolate reductase (DHFR), resulting in impaired folate-mediated biosynthesis, which is reversed by recombinant expression of E. coli DHFR.	Folic Acid	34-40	Dihydrofolate reductase	Escherichia coli	52-56
31058257-6	2019	But the high NADP inhibits dihydrofolate reductase (DHFR), resulting in impaired folate-mediated biosynthesis, which is reversed by recombinant expression of E. coli DHFR.	Folic Acid	34-40	Dihydrofolate reductase	Escherichia coli	166-170
25194438-1	2014	BACKGROUND: The serine hydroxymethyltransferase (SHMT1) is the key enzyme in the folate metabolic pathway to provide one-carbon unit that plays an important role in biosynthesis.	Folic Acid	81-87	serine hydroxymethyltransferase 1	Homo sapiens	49-54
30683931-0	2019	Maternal folic acid supplementation reduces the severity of cleft palate in Tgf-beta3 null mutant mice.	Folic Acid	9-19	transforming growth factor, beta 3	Mus musculus	76-85
30777123-0	2019	A randomized controlled trial of folic acid intervention in pregnancy highlights a putative methylation-regulated control element at ZFP57.	Folic Acid	33-43	ZFP57 zinc finger protein	Homo sapiens	133-138
30777123-9	2019	CONCLUSIONS: These results strengthen the link between folic acid supplementation during later pregnancy and epigenetic changes and identify a novel mechanism for regulation of ZFP57.	Folic Acid	55-65	ZFP57 zinc finger protein	Homo sapiens	177-182
30280318-5	2019	FRbeta harbors a nanomolar binding affinity for folic acid allowing this receptor to be exploited for RA disease imaging (e.g., folate-conjugated PET tracers) and therapeutic targeting (e.g., folate antagonists and folate-conjugated drugs).	Folic Acid	48-58	folate receptor beta	Homo sapiens	0-6
30280318-5	2019	FRbeta harbors a nanomolar binding affinity for folic acid allowing this receptor to be exploited for RA disease imaging (e.g., folate-conjugated PET tracers) and therapeutic targeting (e.g., folate antagonists and folate-conjugated drugs).	Folic Acid	128-134	folate receptor beta	Homo sapiens	0-6
30280318-5	2019	FRbeta harbors a nanomolar binding affinity for folic acid allowing this receptor to be exploited for RA disease imaging (e.g., folate-conjugated PET tracers) and therapeutic targeting (e.g., folate antagonists and folate-conjugated drugs).	Folic Acid	192-198	folate receptor beta	Homo sapiens	0-6
30280318-5	2019	FRbeta harbors a nanomolar binding affinity for folic acid allowing this receptor to be exploited for RA disease imaging (e.g., folate-conjugated PET tracers) and therapeutic targeting (e.g., folate antagonists and folate-conjugated drugs).	Folic Acid	192-198	folate receptor beta	Homo sapiens	0-6
30447272-8	2019	Moreover, maternal folic acid deficiency downregulated Bcl-2 and upregulated Bax, and this effect associate with maternal folic acid deficient increases expression of microRNA-34a.	Folic Acid	19-29	BCL2 associated X, apoptosis regulator	Rattus norvegicus	77-80
30447272-8	2019	Moreover, maternal folic acid deficiency downregulated Bcl-2 and upregulated Bax, and this effect associate with maternal folic acid deficient increases expression of microRNA-34a.	Folic Acid	122-132	BCL2 associated X, apoptosis regulator	Rattus norvegicus	77-80
30205148-10	2018	Prenatal folic acid supplement reversed the decrease of body weight caused by maternal ethanol treatment and ameliorated the increment of glutathione reductase specific activities as well as the increase of thiobarbituric acid reactive substances (TBARS) induced by alcohol in a rats model (Cano et al., 2001).	Folic Acid	9-19	glutathione-disulfide reductase	Rattus norvegicus	138-159
30298448-7	2018	Western blots showed that LC3-II and P62 were also changed in folate-deficient mice.	Folic Acid	62-68	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	26-29
30298448-8	2018	Compared with control mice, a few punctuate LC3-II structures were detected in the folate deficiency group by immunofluorescence.	Folic Acid	83-89	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	44-47
30226590-3	2018	The present study developed FOLR1-targeting porphyrin-lipid nanoparticles (folate-porphysomes, FP) for the treatment of PDT.	Folic Acid	75-81	folate receptor alpha	Homo sapiens	28-33
30049295-9	2018	Results: The results were compared with the Standard Method Performance Requirements (SMPR 2011.006) established for folate.	Folic Acid	117-123	mannose-6-phosphate receptor, cation dependent	Homo sapiens	86-90
29984403-7	2018	The function of CCL20 in nephrotoxic folic acid-induced AKI was assessed by using neutralising anti-CCL20 antibodies or CCR6-deficient mice.	Folic Acid	37-47	chemokine (C-C motif) ligand 20	Mus musculus	16-21
30198140-6	2018	Three folate genes (C677T-MTHFR, C1420T-SHMT, and 2R > 3R-TS) strengthen this effect in spring, and another (T401C-MTHFD) in summer.	Folic Acid	6-12	serine hydroxymethyltransferase 1	Homo sapiens	40-44
29380373-10	2018	Folic acid induced nephropathy was associated with the overexpression of inflammatory markers MCP-1, F4/80, type IV collagen, fibronectin and TGF-beta1 compared to control groups, which were partially attenuated by metformin treatment.	Folic Acid	0-10	fibronectin 1	Mus musculus	126-137
29986308-2	2018	Fetal folate availability is dependent on maternal folate levels and placental folate transport capacity, mediated by two key transporters, Folate Receptor-alpha and Reduced Folate Carrier (RFC).	Folic Acid	6-12	folate receptor alpha	Homo sapiens	140-161
30116142-5	2018	Folic acid and choline decreased C-C motif chemokine ligand 2 (CCL2) mRNA levels.	Folic Acid	0-10	C-C motif chemokine ligand 2	Homo sapiens	33-61
30116142-5	2018	Folic acid and choline decreased C-C motif chemokine ligand 2 (CCL2) mRNA levels.	Folic Acid	0-10	C-C motif chemokine ligand 2	Homo sapiens	63-67
29687876-0	2018	The intervention of enalapril maleate and folic acid tablet on the expressions of the GRP78 and CHOP and vascular remodeling in the vascular smooth muscle cells of H-hypertensive rats with homocysteine.	Folic Acid	42-52	DNA-damage inducible transcript 3	Rattus norvegicus	96-100
29687876-2	2018	We aim to investigate the effect of enalapril maleate and folic acid tablet on the expressions of GRP78 and CHOP and vascular remodeling in a homocysteine (HCY)-treated hypertensive rat model.	Folic Acid	58-68	DNA-damage inducible transcript 3	Rattus norvegicus	108-112
29687876-14	2018	The expressions of GRP78 and CHOP in methionine group were significantly elevated compared to that of control in a time dependent manner (p < 0.05), which were remarkably down regulated in enalapril maleate and folic acid tablet group compared with that in methionine group.	Folic Acid	211-221	DNA-damage inducible transcript 3	Rattus norvegicus	29-33
29370120-6	2018	Dietary VMP supplementation for 56 days significantly increased circulating levels of quercetin, vitamin C, RBC folate and partially prevented the decline in vitamin B6 and B12 status.	Folic Acid	112-118	neurensin 1	Homo sapiens	8-11
29321536-5	2018	Our results revealed that these genes could be novel and more promising anticancer targets than dihydrofolate reductase (DHFR), the current target of drug therapy linked with folate metabolism, suggesting the rationale of drug discovery in cancer medicine.	Folic Acid	103-109	dihydrofolate reductase	Homo sapiens	121-125
29208467-1	2018	The human proton coupled folic acid transporter PCFT is the major import route for dietary folates.	Folic Acid	91-98	solute carrier family 46 member 1	Homo sapiens	48-52
29208467-2	2018	Mutations in the gene encoding PCFT cause hereditary folic acid malabsorption, which manifests itself by compromised folate absorption from the intestine and also in impaired folate transport into the central nervous system.	Folic Acid	117-123	solute carrier family 46 member 1	Homo sapiens	31-35
29208467-2	2018	Mutations in the gene encoding PCFT cause hereditary folic acid malabsorption, which manifests itself by compromised folate absorption from the intestine and also in impaired folate transport into the central nervous system.	Folic Acid	175-181	solute carrier family 46 member 1	Homo sapiens	31-35
29208467-7	2018	We found that purified detergent solubilized PCFT was able to bind folic acid, thus indicating a functionally active protein.	Folic Acid	67-77	solute carrier family 46 member 1	Homo sapiens	45-49
29344585-0	2018	Hereditary folate malabsorption due to a mutation in the external gate of the proton-coupled folate transporter SLC46A1.	Folic Acid	11-17	solute carrier family 46 member 1	Homo sapiens	112-119
29344585-1	2018	Hereditary folate malabsorption (HFM) is an autosomal recessive disorder characterized by impaired intestinal folate absorption and impaired folate transport across the choroid plexus due to loss of function of the proton-coupled folate transporter (PCFT-SLC46A1).	Folic Acid	11-17	solute carrier family 46 member 1	Homo sapiens	250-254
29344585-1	2018	Hereditary folate malabsorption (HFM) is an autosomal recessive disorder characterized by impaired intestinal folate absorption and impaired folate transport across the choroid plexus due to loss of function of the proton-coupled folate transporter (PCFT-SLC46A1).	Folic Acid	11-17	solute carrier family 46 member 1	Homo sapiens	255-262
29109127-4	2018	The regulatory locus also expresses two functional RNAs, LINC00925-RNA and MIR9-3, which are coexpressed with POLG The MIR9-3 targets include NR2E1, a transcription factor maintaining neural stem cells in undifferentiated state, and MTHFD2, the regulatory enzyme of mitochondrial folate cycle, linking POLG expression to stem cell differentiation and folate metabolism.	Folic Acid	280-286	DNA polymerase gamma, catalytic subunit	Homo sapiens	110-114
29109127-4	2018	The regulatory locus also expresses two functional RNAs, LINC00925-RNA and MIR9-3, which are coexpressed with POLG The MIR9-3 targets include NR2E1, a transcription factor maintaining neural stem cells in undifferentiated state, and MTHFD2, the regulatory enzyme of mitochondrial folate cycle, linking POLG expression to stem cell differentiation and folate metabolism.	Folic Acid	280-286	microRNA 9-3	Homo sapiens	119-125
28685492-1	2018	Hereditary folate malabsorption is a rare autosomal recessive disorder caused by impaired active folate transport across membranes and into the central nervous system due to loss-of-function mutations in proton-coupled folate transporter (PCFT).	Folic Acid	11-17	solute carrier family 46 member 1	Homo sapiens	204-237
28685492-1	2018	Hereditary folate malabsorption is a rare autosomal recessive disorder caused by impaired active folate transport across membranes and into the central nervous system due to loss-of-function mutations in proton-coupled folate transporter (PCFT).	Folic Acid	11-17	solute carrier family 46 member 1	Homo sapiens	239-243
28685492-1	2018	Hereditary folate malabsorption is a rare autosomal recessive disorder caused by impaired active folate transport across membranes and into the central nervous system due to loss-of-function mutations in proton-coupled folate transporter (PCFT).	Folic Acid	97-103	solute carrier family 46 member 1	Homo sapiens	204-237
28685492-1	2018	Hereditary folate malabsorption is a rare autosomal recessive disorder caused by impaired active folate transport across membranes and into the central nervous system due to loss-of-function mutations in proton-coupled folate transporter (PCFT).	Folic Acid	97-103	solute carrier family 46 member 1	Homo sapiens	239-243
28939533-3	2017	This requires considering a set of experimentally validated protein targets in the folate pathway of major pathogenic trypanosomatid parasites and humans: (i) the primary parasite on-targets: pteridine reductase 1 (PTR1) (absent in humans) and bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS), (ii) the primary off-targets: human DHFR and TS, and (iii) the secondary on-target: human folate receptor beta, a folate/antifolate transporter.	Folic Acid	83-89	dihydrofolate reductase	Homo sapiens	303-307
28939533-3	2017	This requires considering a set of experimentally validated protein targets in the folate pathway of major pathogenic trypanosomatid parasites and humans: (i) the primary parasite on-targets: pteridine reductase 1 (PTR1) (absent in humans) and bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS), (ii) the primary off-targets: human DHFR and TS, and (iii) the secondary on-target: human folate receptor beta, a folate/antifolate transporter.	Folic Acid	83-89	dihydrofolate reductase	Homo sapiens	349-353
28939533-3	2017	This requires considering a set of experimentally validated protein targets in the folate pathway of major pathogenic trypanosomatid parasites and humans: (i) the primary parasite on-targets: pteridine reductase 1 (PTR1) (absent in humans) and bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS), (ii) the primary off-targets: human DHFR and TS, and (iii) the secondary on-target: human folate receptor beta, a folate/antifolate transporter.	Folic Acid	83-89	folate receptor beta	Homo sapiens	403-423
28608983-0	2017	Folic acid reduces doxorubicin-induced cardiomyopathy by modulating endothelial nitric oxide synthase.	Folic Acid	0-10	nitric oxide synthase 3, endothelial cell	Mus musculus	68-101
29955722-0	2018	Addition of Exogenous gamma-Glutamyl Hydrolase Eliminates the Need for Lengthy Incubation of Whole-Blood Lysate for Quantitation of Folate Vitamers by High-Performance Liquid Chromatography-Tandem Mass Spectrometry.	Folic Acid	132-138	gamma-glutamyl hydrolase	Homo sapiens	22-46
29955722-2	2018	Objective: We explored whether the addition of a commercially available recombinant exogenous gamma-glutamyl hydrolase (exoGGH) enzyme reduced the required incubation time of WBL for measurement of folate as monoglutamates.	Folic Acid	198-204	gamma-glutamyl hydrolase	Homo sapiens	94-118
29207668-1	2017	Despite recent studies have demonstrated that the EGF receptor (EGFR) activation provided a renoprotective role during ischemic and folic acid-induced AKI, the role and regulation mechanism of EGFR in septic AKI remains unclear.	Folic Acid	132-142	epidermal growth factor receptor	Mus musculus	50-62
29207668-1	2017	Despite recent studies have demonstrated that the EGF receptor (EGFR) activation provided a renoprotective role during ischemic and folic acid-induced AKI, the role and regulation mechanism of EGFR in septic AKI remains unclear.	Folic Acid	132-142	epidermal growth factor receptor	Mus musculus	64-68
28731321-0	2017	Conjugation Dependent Interaction of Folic Acid with Folate Binding Protein.	Folic Acid	37-47	folate receptor alpha	Homo sapiens	53-75
28731321-1	2017	Serum proteins play a critical role in the transport, uptake, and efficacy of targeted drug therapies, and here we investigate the interactions between folic acid-polymer conjugates and serum folate binding protein (FBP), the soluble form of the cellular membrane-bound folate receptor.	Folic Acid	152-162	folate receptor alpha	Homo sapiens	192-214
28731321-1	2017	Serum proteins play a critical role in the transport, uptake, and efficacy of targeted drug therapies, and here we investigate the interactions between folic acid-polymer conjugates and serum folate binding protein (FBP), the soluble form of the cellular membrane-bound folate receptor.	Folic Acid	152-162	folate receptor alpha	Homo sapiens	216-219
28731321-2	2017	We demonstrate that both choice of polymer and method of ligand conjugation affect the interactions between folic acid-polymer conjugates and serum FBP, resulting in changes in the folic acid-induced protein aggregation process.	Folic Acid	108-118	folate receptor alpha	Homo sapiens	148-151
28731321-2	2017	We demonstrate that both choice of polymer and method of ligand conjugation affect the interactions between folic acid-polymer conjugates and serum FBP, resulting in changes in the folic acid-induced protein aggregation process.	Folic Acid	181-191	folate receptor alpha	Homo sapiens	148-151
28731321-4	2017	When poly(amidoamine) dendrimer-folic acid conjugates bound to FBP, the distribution of nanoparticles was preserved.	Folic Acid	32-42	folate receptor alpha	Homo sapiens	63-66
28731321-6	2017	In contrast, poly(ethylene glycol)-folic acid conjugates demonstrated substantially reduced binding to FBP, did not cause folic acid-induced aggregation, and fully disrupted FBP self-aggregation.	Folic Acid	35-45	folate receptor alpha	Homo sapiens	103-106
28731321-6	2017	In contrast, poly(ethylene glycol)-folic acid conjugates demonstrated substantially reduced binding to FBP, did not cause folic acid-induced aggregation, and fully disrupted FBP self-aggregation.	Folic Acid	35-45	folate receptor alpha	Homo sapiens	174-177
28731321-9	2017	Our results suggest that prebinding therapeutic nanocarriers to serum FBP may allow folate-specific metabolic pathways to be exploited for delivery while also affording benefits of utilizing an endogenous protein as a vector.	Folic Acid	84-90	folate receptor alpha	Homo sapiens	70-73
29075112-0	2017	Effect of inhibitors of endocytosis and NF-kB signal pathway on folate-conjugated nanoparticle endocytosis by rat Kupffer cells.	Folic Acid	64-70	nuclear factor kappa B subunit 1	Rattus norvegicus	40-45
29075112-3	2017	In this study, we reduced the phagocytosis of epirubicin (EPI)-loaded folic acid-conjugated pullulan acetate (FPA/EPI) nanoparticles by Kupffer cells (KCs) through internalization and nuclear factor kappa B (NF-kB) signal pathway inhibitors, thus allowing development of FPA/EPI nanoparticles as a nanodrug delivery system (NDDS) based on our previous study.	Folic Acid	70-80	nuclear factor kappa B subunit 1	Rattus norvegicus	208-213
28849826-3	2017	In this study, we designed a novel folic acid-PEG-conjugated p-phosphonated calix[4]arene nanoparticle (Fp-PCN) for the simultaneous delivery of paclitaxel (PAC) and carboplatin (CAR) at an optimal ratio (5 : 1, mol : mol) to utilize their potential synergistic effect against OC cells.	Folic Acid	35-45	CXADR pseudogene 1	Homo sapiens	179-182
28244241-4	2017	Folate receptor (Folr) is one of the three membrane proteins that mediate cellular uptake of folates.	Folic Acid	93-100	folate receptor alpha	Homo sapiens	0-15
28244241-4	2017	Folate receptor (Folr) is one of the three membrane proteins that mediate cellular uptake of folates.	Folic Acid	93-100	folate receptor alpha	Homo sapiens	17-21
28658642-1	2017	The current study utilizes folic acid conjugated poly(styrene-co-maleic anhydride) block copolymer (FA-SMA) to enhance the solubility of a hydrophobic but very potent synthetic curcumin-difluorinated (CDF) analog and its targeted delivery to folate receptor-alpha overexpressing cancers.	Folic Acid	27-37	folate receptor alpha	Homo sapiens	242-263
28592519-8	2017	Folate sensing by mTOR in PHT cells is independent of the accumulation of homocysteine and requires the proton-coupled folate transporter (PCFT; solute carrier 46A1).	Folic Acid	0-6	solute carrier family 46 member 1	Homo sapiens	104-137
28592519-8	2017	Folate sensing by mTOR in PHT cells is independent of the accumulation of homocysteine and requires the proton-coupled folate transporter (PCFT; solute carrier 46A1).	Folic Acid	0-6	solute carrier family 46 member 1	Homo sapiens	139-143
28592519-9	2017	Furthermore, mTORC1 and mTORC2 regulate trophoblast folate uptake by modulating the cell surface expression of folate receptor alpha and the reduced folate carrier.	Folic Acid	52-58	folate receptor alpha	Homo sapiens	111-132
28685068-0	2017	Protein and mRNA expression of folic acid-associated enzymes as biomarkers for the cytotoxicity of the thymidylate synthase-targeted drugs, pemetrexed and S-1, in non-small cell lung cancer.	Folic Acid	31-41	thymidylate synthetase	Homo sapiens	103-123
28685068-1	2017	The thymidylate synthase (TS)-targeted drugs, pemetrexed and S-1, exert an important role in advanced non-small cell lung cancer (NSCLC) treatment; folic acid-associated enzymes are expected to behave as biomarkers, although their role has yet to be fully elucidated.	Folic Acid	148-158	thymidylate synthetase	Homo sapiens	4-24
28685068-1	2017	The thymidylate synthase (TS)-targeted drugs, pemetrexed and S-1, exert an important role in advanced non-small cell lung cancer (NSCLC) treatment; folic acid-associated enzymes are expected to behave as biomarkers, although their role has yet to be fully elucidated.	Folic Acid	148-158	thymidylate synthetase	Homo sapiens	26-28
28142123-8	2017	We have demonstrated that the proposed nanocarrier SERS sensor can be utilized to investigate attachment of targeting ligands to nanocarriers (attachment of folic acid ligand recognized by folate receptors of cancer cells is described).	Folic Acid	157-167	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	51-55
28493963-5	2017	We demonstrate folate transport functionality along the PCFT expression, isolation, and purification process.	Folic Acid	15-21	solute carrier family 46 member 1	Homo sapiens	56-60
28493963-6	2017	Importantly, purified PCFT transports folic acid after reconstitution.	Folic Acid	38-48	solute carrier family 46 member 1	Homo sapiens	22-26
28496320-2	2017	Recently, we revealed that folate-appended methyl-beta-cyclodextrin (FA-M-beta-CyD) provides selective antitumor activity in folate receptor-alpha (FR-alpha)-expressing cells by the induction of autophagy.	Folic Acid	27-33	folate receptor alpha	Homo sapiens	125-146
28496320-2	2017	Recently, we revealed that folate-appended methyl-beta-cyclodextrin (FA-M-beta-CyD) provides selective antitumor activity in folate receptor-alpha (FR-alpha)-expressing cells by the induction of autophagy.	Folic Acid	27-33	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	148-156
28199771-2	2017	FRAAs disrupt folate transport across the blood-brain barrier by binding to the FRalpha.	Folic Acid	14-20	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	80-87
28147266-4	2017	In contrast, deprivation of maternal dietary protein in utero provoked permanent de-repression of imprinted Cdkn1c expression that was sustained into adulthood and occurred through a folate-dependent mechanism of DNA methylation loss.	Folic Acid	183-189	cyclin-dependent kinase inhibitor 1C (P57)	Mus musculus	108-114
28146062-1	2017	gamma-glutamyl-hydrolase (GGH) is a ubiquitously-expressed enzyme that regulates intracellular folate metabolism for cell proliferation, DNA synthesis, and repair.	Folic Acid	95-101	gamma-glutamyl hydrolase	Homo sapiens	0-24
28146062-1	2017	gamma-glutamyl-hydrolase (GGH) is a ubiquitously-expressed enzyme that regulates intracellular folate metabolism for cell proliferation, DNA synthesis, and repair.	Folic Acid	95-101	gamma-glutamyl hydrolase	Homo sapiens	26-29
27523499-9	2017	Cerebral folate deficiency (N=12) was most common, with normal serum folate levels and low CSF 5-methyltetrahydrofolate (5-MTHF) levels.	Folic Acid	9-15	colony stimulating factor 2	Homo sapiens	91-94
28284395-5	2016	PCFT and FOLR1 ensure intestinal absorption and transport of folate through the blood-brain barrier and SLC19A25 transports thiamine into the mitochondria.	Folic Acid	61-67	solute carrier family 46 member 1	Homo sapiens	0-4
28284395-5	2016	PCFT and FOLR1 ensure intestinal absorption and transport of folate through the blood-brain barrier and SLC19A25 transports thiamine into the mitochondria.	Folic Acid	61-67	folate receptor alpha	Homo sapiens	9-14
27637357-3	2016	In the treatment of cancer with 5-fluorouracil, the administration of folates mechanistically leads to the formation of [6R]-5,10-methylene-tetrahydrofolate, and the increased concentration of this molecule leads to stabilization of the ternary complex comprising thymidylate synthase, 2"-deoxy-uridine-5"-monophosphate, and [6R]-5,10-methylene-tetrahydrofolate.	Folic Acid	70-77	thymidylate synthetase	Homo sapiens	264-284
27637357-5	2016	Modulation of thymidylate synthase activity became central in the study of folate/cytotoxic combinations and, despite wide use, research into the folate component was neglected, leaving important questions unanswered.	Folic Acid	75-81	thymidylate synthetase	Homo sapiens	14-34
26224648-3	2016	We hypothesized that folic acid supplementation may protect neuron cells from amyloid beta (Abeta) oligomer-induced toxicity by modulating DNA methylation of APP and PS1 in AD models.	Folic Acid	21-31	amyloid beta (A4) precursor protein	Mus musculus	92-97
26224648-3	2016	We hypothesized that folic acid supplementation may protect neuron cells from amyloid beta (Abeta) oligomer-induced toxicity by modulating DNA methylation of APP and PS1 in AD models.	Folic Acid	21-31	presenilin 1	Mus musculus	166-169
26224648-8	2016	Folic acid dose-dependently stimulated methylation potential and DNMT activity, altered PS1 and APP promoter methylation, decreased PS1 and APP expression, and partially preserved cell viability.	Folic Acid	0-10	presenilin 1	Mus musculus	88-91
26224648-8	2016	Folic acid dose-dependently stimulated methylation potential and DNMT activity, altered PS1 and APP promoter methylation, decreased PS1 and APP expression, and partially preserved cell viability.	Folic Acid	0-10	presenilin 1	Mus musculus	132-135
26224648-9	2016	Folic acid increased PS1 and APP promoter methylation in AD transgenic mice.	Folic Acid	0-10	presenilin 1	Mus musculus	21-24
26224648-10	2016	CONCLUSION: These results suggest a mechanism by which folic acid may prevent Abeta oligomer-induced neuronal toxicity.	Folic Acid	55-65	amyloid beta (A4) precursor protein	Mus musculus	78-83
27113042-11	2016	These findings demonstrated that folic acid protected neuronal cells against Al-malt-induced apoptosis by preventing the downregulation of miR-19 and modulation of miR-19 related downstream PTEN/AKT/p53 pathway.	Folic Acid	33-43	phosphatase and tensin homolog	Homo sapiens	190-194
27165830-7	2016	Upregulated TG2 and impaired renal function were apparent with EST delivery combined with folic acid-induced nephropathy.	Folic Acid	90-100	transglutaminase 2, C polypeptide	Mus musculus	12-15
26990146-3	2016	In adult group, 3 and 5 months of folate deficiency decreased serum and tissue folate levels with decreased uptake of folate, further associated with decreased expression levels of reduced folate carrier (RFC) and increased expression levels of folate exporter (ABCG2) at both mRNA and protein levels, which in turn regulated by promoter hypermethylation of RFC and promoter hypomethylation of ABCG2 gene.	Folic Acid	34-40	ATP binding cassette subfamily G member 2	Rattus norvegicus	262-267
26990146-3	2016	In adult group, 3 and 5 months of folate deficiency decreased serum and tissue folate levels with decreased uptake of folate, further associated with decreased expression levels of reduced folate carrier (RFC) and increased expression levels of folate exporter (ABCG2) at both mRNA and protein levels, which in turn regulated by promoter hypermethylation of RFC and promoter hypomethylation of ABCG2 gene.	Folic Acid	34-40	ATP binding cassette subfamily G member 2	Rattus norvegicus	394-399
26990146-4	2016	CONCLUSION: Promoter hypermethylation of RFC and promoter hypomethylation of ABCG2 may be attributed to the down regulation of RFC and up regulation of ABCG2 at mRNA and protein levels in conditions of 3 and 5 months of folate deficiency in the adult group.	Folic Acid	220-226	ATP binding cassette subfamily G member 2	Rattus norvegicus	77-82
26990146-4	2016	CONCLUSION: Promoter hypermethylation of RFC and promoter hypomethylation of ABCG2 may be attributed to the down regulation of RFC and up regulation of ABCG2 at mRNA and protein levels in conditions of 3 and 5 months of folate deficiency in the adult group.	Folic Acid	220-226	ATP binding cassette subfamily G member 2	Rattus norvegicus	152-157
26789141-2	2016	However, no previous reports have examined the major gene responsible for folate uptake, the proton-coupled folate transporter (SLC46A1).	Folic Acid	74-80	solute carrier family 46 member 1	Homo sapiens	128-135
26096018-2	2016	The human thymidylate synthase and dihydrofolate reductase catalyze two consecutive reactions in the folate metabolism pathway, and experiments have shown that they are very likely to bind in the same multi-enzyme complex in vivo.	Folic Acid	42-48	thymidylate synthetase	Homo sapiens	10-30
27213086-1	2016	Structural basis for exploration into MDM2 and MDM2-DHFR interaction plays a vital role in analyzing the obstruction in folate metabolism, nonsynthesis of purines, and further epigenetic regulation in Homo sapiens.	Folic Acid	120-126	dihydrofolate reductase	Homo sapiens	52-56
26494555-5	2015	We treated human H1299 lung cancer cells with HuR-specific siRNA contained in a folate-targeted lipid nanoparticle (HuR-FNP) plus AMD3100, and compared this with AMD3100 alone, HuR-FNP alone and no treatment.	Folic Acid	80-86	ELAV like RNA binding protein 1	Homo sapiens	46-49
26494555-5	2015	We treated human H1299 lung cancer cells with HuR-specific siRNA contained in a folate-targeted lipid nanoparticle (HuR-FNP) plus AMD3100, and compared this with AMD3100 alone, HuR-FNP alone and no treatment.	Folic Acid	80-86	ELAV like RNA binding protein 1	Homo sapiens	116-119
26494555-5	2015	We treated human H1299 lung cancer cells with HuR-specific siRNA contained in a folate-targeted lipid nanoparticle (HuR-FNP) plus AMD3100, and compared this with AMD3100 alone, HuR-FNP alone and no treatment.	Folic Acid	80-86	ELAV like RNA binding protein 1	Homo sapiens	116-119
26345540-0	2015	Folic acid deficiency enhances abeta accumulation in APP/PS1 mice brain and decreases amyloid-associated miRNAs expression.	Folic Acid	0-10	presenilin 1	Mus musculus	57-60
26345540-4	2015	We aimed to find if folic acid deficiency may enhance amyloid-beta (Abeta) peptide deposition and regulate amyloid-associated miRNAs and their target genes expression in APP/PS1 mice.	Folic Acid	20-30	amyloid beta (A4) precursor protein	Mus musculus	68-73
26345540-4	2015	We aimed to find if folic acid deficiency may enhance amyloid-beta (Abeta) peptide deposition and regulate amyloid-associated miRNAs and their target genes expression in APP/PS1 mice.	Folic Acid	20-30	presenilin 1	Mus musculus	174-177
26345540-14	2015	In APP/PS1 mice brains and N2a cells with folic acid-deficient treatment, miR-106a-5p, miR-200b-3p and miR-339-5p were down-regulated, and their target genes APP and BACE1 were up-regulated.	Folic Acid	42-52	presenilin 1	Mus musculus	7-10
26345540-14	2015	In APP/PS1 mice brains and N2a cells with folic acid-deficient treatment, miR-106a-5p, miR-200b-3p and miR-339-5p were down-regulated, and their target genes APP and BACE1 were up-regulated.	Folic Acid	42-52	microRNA 106a	Mus musculus	74-82
26345540-14	2015	In APP/PS1 mice brains and N2a cells with folic acid-deficient treatment, miR-106a-5p, miR-200b-3p and miR-339-5p were down-regulated, and their target genes APP and BACE1 were up-regulated.	Folic Acid	42-52	beta-site APP cleaving enzyme 1	Mus musculus	166-171
26345540-15	2015	In conclusion, folic acid deficiency can enhance Abeta accumulation in APP/PS1 mice brain and decrease amyloid-associated miRNAs expression.	Folic Acid	15-25	amyloid beta (A4) precursor protein	Mus musculus	49-54
26345540-15	2015	In conclusion, folic acid deficiency can enhance Abeta accumulation in APP/PS1 mice brain and decrease amyloid-associated miRNAs expression.	Folic Acid	15-25	presenilin 1	Mus musculus	75-78
26579709-6	2015	We show, for the first time, that IDO mediates human tumor cell resistance to the candidate anticancer drugs FK866 (an NAD+ inhibitor), methoxyamine (MX, a base excision repair [BER] inhibitor) and approved anticancer drugs pemetrexed (a folate anti-metabolite) and gemcitabine (a nucleoside analogue), and combined treatment with pemetrexed and MX, in the absence of immune cells.	Folic Acid	238-244	indoleamine 2,3-dioxygenase 1	Homo sapiens	34-37
26400185-9	2015	Consistent with in vivo findings, 5-methyltetrahydrofolate (bioactive form of folate) restored phosphorylation (activation) of both AMPK and LKB1 in palmitic acid-treated HepG2 cells.	Folic Acid	52-58	serine/threonine kinase 11	Homo sapiens	141-145
26414244-8	2015	Application of folic acid (FA) restored DHFR levels, NO bioavailability, and BH4 levels under hypoxia.	Folic Acid	15-25	dihydrofolate reductase	Homo sapiens	40-44
26354538-2	2015	In search of an explanation, we hypothesized that the association of folate with cognition would be modified by the interaction of high-folate status with a common 19-bp deletion polymorphism in the dihydrofolate reductase (DHFR) gene.	Folic Acid	69-75	dihydrofolate reductase	Homo sapiens	199-222
26354538-2	2015	In search of an explanation, we hypothesized that the association of folate with cognition would be modified by the interaction of high-folate status with a common 19-bp deletion polymorphism in the dihydrofolate reductase (DHFR) gene.	Folic Acid	69-75	dihydrofolate reductase	Homo sapiens	224-228
26354538-2	2015	In search of an explanation, we hypothesized that the association of folate with cognition would be modified by the interaction of high-folate status with a common 19-bp deletion polymorphism in the dihydrofolate reductase (DHFR) gene.	Folic Acid	136-142	dihydrofolate reductase	Homo sapiens	199-222
26354538-2	2015	In search of an explanation, we hypothesized that the association of folate with cognition would be modified by the interaction of high-folate status with a common 19-bp deletion polymorphism in the dihydrofolate reductase (DHFR) gene.	Folic Acid	136-142	dihydrofolate reductase	Homo sapiens	224-228
26492244-3	2015	We hypothesized that folic acid supplementation modulates DNA methyltransferase (DNMT) activity and may alter amyloid beta-peptide (Abeta) production in AD.	Folic Acid	21-31	amyloid beta (A4) precursor protein	Mus musculus	132-137
26492244-7	2015	Furthermore, folic acid decreased Abeta protein production, whereas inhibition of DNMT activity by zebularine increased Abeta production.	Folic Acid	13-23	amyloid beta (A4) precursor protein	Mus musculus	34-39
26492244-8	2015	The results indicate that folic acid induces methylation potential-dependent DNMT enzymes, thereby attenuating Abeta production.	Folic Acid	26-36	amyloid beta (A4) precursor protein	Mus musculus	111-116
23601781-2	2013	The proton-coupled folate transporter (PCFT; SLC46A1) has been identified as the major contributor for intestinal folate uptake.	Folic Acid	19-25	solute carrier family 46 member 1	Homo sapiens	39-43
26269242-1	2015	BACKGROUND: Dihydrofolate reductase (DHFR) is essential for the conversion of folic acid to active folate needed for one-carbon metabolism.	Folic Acid	78-88	dihydrofolate reductase	Homo sapiens	12-35
23601781-2	2013	The proton-coupled folate transporter (PCFT; SLC46A1) has been identified as the major contributor for intestinal folate uptake.	Folic Acid	19-25	solute carrier family 46 member 1	Homo sapiens	45-52
23601781-8	2013	The functionality of the utilized PCFT construct was confirmed in oocytes by folic acid induced currents at acidic pH.	Folic Acid	77-87	solute carrier family 46 member 1	Homo sapiens	34-38
23601781-9	2013	For both the oocyte and CHO expression system [(3)H]folic acid uptake studies indicated that PCFT was functional.	Folic Acid	52-62	solute carrier family 46 member 1	Homo sapiens	93-97
23611499-4	2013	Examination of the crystal structures identifies a Mg(2+) near the glutamyl moiety of the folate cofactor, providing the first structural evidence for Mg(2+) binding to TSase.	Folic Acid	90-96	thymidylate synthetase	Homo sapiens	169-174
22932126-9	2013	In folic acid-treated Xenopus eggs, extracellular signal-regulated kinase 1 was phosphorylated, cyclin B2 and Mos were up-regulated and the frequency of GVBD was accelerated.	Folic Acid	3-13	cyclin B2 S homeolog	Xenopus laevis	96-105
22932126-9	2013	In folic acid-treated Xenopus eggs, extracellular signal-regulated kinase 1 was phosphorylated, cyclin B2 and Mos were up-regulated and the frequency of GVBD was accelerated.	Folic Acid	3-13	MOS proto-oncogene, serine/threonine kinase L homeolog	Xenopus laevis	110-113
24302446-4	2014	Treatment with folic acid and tributyrin alone or in combination strongly inhibited the development of glutathione-S-transferase placental form (GSTP)-positive foci.	Folic Acid	15-25	hematopoietic prostaglandin D synthase	Rattus norvegicus	103-128
24302446-6	2014	A total of 498, 655 and 940 of differentially expressed genes, involved in cell cycle, p53-signaling, angiogenesis and Wnt pathways, was identified in the livers of rats treated with folic acid, tributyrin or folic acid and tributyrin.	Folic Acid	183-193	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	87-90
24302446-6	2014	A total of 498, 655 and 940 of differentially expressed genes, involved in cell cycle, p53-signaling, angiogenesis and Wnt pathways, was identified in the livers of rats treated with folic acid, tributyrin or folic acid and tributyrin.	Folic Acid	209-219	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	87-90
24688052-0	2014	KRAS mutation status is associated with enhanced dependency on folate metabolism pathways in non-small cell lung cancer cells.	Folic Acid	63-69	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	0-4
24688052-3	2014	This study identified a greater dependency on folate metabolism pathways in KRAS mutant compared with KRAS wild-type NSCLC cell lines.	Folic Acid	46-52	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	76-80
26269242-1	2015	BACKGROUND: Dihydrofolate reductase (DHFR) is essential for the conversion of folic acid to active folate needed for one-carbon metabolism.	Folic Acid	78-88	dihydrofolate reductase	Homo sapiens	37-41
26269242-1	2015	BACKGROUND: Dihydrofolate reductase (DHFR) is essential for the conversion of folic acid to active folate needed for one-carbon metabolism.	Folic Acid	19-25	dihydrofolate reductase	Homo sapiens	37-41
23357463-2	2013	Folate receptor alpha (FOLR1), a folate transporter, is an attractive target for anti-neoplastic therapy due to its high affinity for folate, restricted range of expression in normal tissue and differential over-expression in malignant tissue.	Folic Acid	33-39	folate receptor alpha	Homo sapiens	0-21
26319423-8	2015	CONCLUSION: Intervention with B12 and folic acid is effective in reducing Hcy, PAI 1, fibrinogen levels and increasing NO levels at 1yr as compared to control arm and reducing the incidence of thrombosis at 2years of stay at HAA.	Folic Acid	38-48	serpin family E member 1	Homo sapiens	79-84
23357463-2	2013	Folate receptor alpha (FOLR1), a folate transporter, is an attractive target for anti-neoplastic therapy due to its high affinity for folate, restricted range of expression in normal tissue and differential over-expression in malignant tissue.	Folic Acid	33-39	folate receptor alpha	Homo sapiens	23-28
24688052-4	2014	Microarray gene expression and biologic pathway analysis identified higher expression of folate metabolism- and purine synthesis-related pathways in KRAS-mutant NSCLC cells compared with wild-type counterparts.	Folic Acid	89-95	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	149-153
24688052-6	2014	Furthermore, KRAS knockdown and overexpression studies demonstrated the ability of KRAS to regulate expression of genes that comprise folate metabolism pathways.	Folic Acid	134-140	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	13-17
24688052-6	2014	Furthermore, KRAS knockdown and overexpression studies demonstrated the ability of KRAS to regulate expression of genes that comprise folate metabolism pathways.	Folic Acid	134-140	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	83-87
24756984-1	2015	Thymidylate synthase (TYMS) plays a crucial role in folate metabolism as well as DNA synthesis and repair.	Folic Acid	52-58	thymidylate synthetase	Homo sapiens	0-20
24705454-1	2014	We report that a shorter Debye length and, as a consequence, decreased colloidal stability are required for the molecular interaction of folic acid-modified Au nanoparticles (Au NPs) to occur on a surface-bound receptor, human dihydrofolate reductase (hDHFR).	Folic Acid	137-147	dihydrofolate reductase	Homo sapiens	227-250
24705454-1	2014	We report that a shorter Debye length and, as a consequence, decreased colloidal stability are required for the molecular interaction of folic acid-modified Au nanoparticles (Au NPs) to occur on a surface-bound receptor, human dihydrofolate reductase (hDHFR).	Folic Acid	137-147	dihydrofolate reductase	Homo sapiens	252-257
24705454-4	2014	Longer Debye lengths led to poorer SPR responses, revealing a reduced affinity of the folic acid-modified Au NPs for hDHFR.	Folic Acid	86-96	dihydrofolate reductase	Homo sapiens	117-122
23463647-5	2013	At weaning, maternal folic acid supplementation significantly decreased global (p &lt; 0.001) and site-specific DNA methylation of the Ppar-gamma, ER-alpha, p53, and Apc genes (p &lt; 0.05) in the liver.	Folic Acid	21-31	estrogen receptor 1	Rattus norvegicus	147-155
23463647-5	2013	At weaning, maternal folic acid supplementation significantly decreased global (p &lt; 0.001) and site-specific DNA methylation of the Ppar-gamma, ER-alpha, p53, and Apc genes (p &lt; 0.05) in the liver.	Folic Acid	21-31	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	157-160
23463647-7	2013	At 14 weeks of age, both maternal and postweaning folic acid supplementation significantly increased DNA methylation of the Ppar-gamma, p53, and p16 genes (p &lt; 0.05) whereas only postweaning FA supplementation significantly increased DNA methylation of the ER-alpha and Apc genes (p &lt; 0.05).	Folic Acid	50-60	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	136-139
23463647-7	2013	At 14 weeks of age, both maternal and postweaning folic acid supplementation significantly increased DNA methylation of the Ppar-gamma, p53, and p16 genes (p &lt; 0.05) whereas only postweaning FA supplementation significantly increased DNA methylation of the ER-alpha and Apc genes (p &lt; 0.05).	Folic Acid	50-60	estrogen receptor 1	Rattus norvegicus	260-268
23506878-5	2013	The proton-coupled folate transporter (PCFT, SLC46A1) is the mechanism by which folates are absorbed across the apical-brush-border membrane of the proximal small intestine.	Folic Acid	80-87	solute carrier family 46 member 1	Homo sapiens	4-37
23506878-5	2013	The proton-coupled folate transporter (PCFT, SLC46A1) is the mechanism by which folates are absorbed across the apical-brush-border membrane of the proximal small intestine.	Folic Acid	80-87	solute carrier family 46 member 1	Homo sapiens	39-43
23506878-5	2013	The proton-coupled folate transporter (PCFT, SLC46A1) is the mechanism by which folates are absorbed across the apical-brush-border membrane of the proximal small intestine.	Folic Acid	80-87	solute carrier family 46 member 1	Homo sapiens	45-52
23506878-6	2013	Two folate receptors (FOLR1 and FOLR2) mediate folate transport across epithelia by an endocytic process.	Folic Acid	4-10	folate receptor alpha	Homo sapiens	22-27
23506878-6	2013	Two folate receptors (FOLR1 and FOLR2) mediate folate transport across epithelia by an endocytic process.	Folic Acid	4-10	folate receptor beta	Homo sapiens	32-37
24639464-0	2014	LRP2 mediates folate uptake in the developing neural tube.	Folic Acid	14-20	low density lipoprotein receptor-related protein 2	Mus musculus	0-4
24639464-6	2014	Consequently, folate concentrations are significantly reduced in Lrp2(-/-) embryos compared with control littermates.	Folic Acid	14-20	low density lipoprotein receptor-related protein 2	Mus musculus	65-69
24756984-1	2015	Thymidylate synthase (TYMS) plays a crucial role in folate metabolism as well as DNA synthesis and repair.	Folic Acid	52-58	thymidylate synthetase	Homo sapiens	22-26
25805165-0	2015	Lipid, Oxidative and Inflammatory Profile and Alterations in the Enzymes Paraoxonase and Butyrylcholinesterase in Plasma of Patients with Homocystinuria Due CBS Deficiency: The Vitamin B12 and Folic Acid Importance.	Folic Acid	193-203	butyrylcholinesterase	Homo sapiens	89-110
24639464-7	2014	Moreover, the folic-acid-dependent gene Alx3 is significantly downregulated in Lrp2 mutants.	Folic Acid	14-24	low density lipoprotein receptor-related protein 2	Mus musculus	79-83
24639464-8	2014	In conclusion, we show that LRP2 is essential for cellular folate uptake in the developing neural tube, a crucial step for proper neural tube closure.	Folic Acid	59-65	low density lipoprotein receptor-related protein 2	Mus musculus	28-32
24725205-4	2014	In this work, the synthesis of a monovalent folic acid-dendrimer conjugate allowed the elucidation of the mechanism for increased binding between the folic acid-polymer conjugate and a folate binding protein surface.	Folic Acid	44-49	folate receptor alpha	Homo sapiens	185-207
24725205-4	2014	In this work, the synthesis of a monovalent folic acid-dendrimer conjugate allowed the elucidation of the mechanism for increased binding between the folic acid-polymer conjugate and a folate binding protein surface.	Folic Acid	44-54	folate receptor alpha	Homo sapiens	185-207
24559276-3	2014	The serine hydroxymethyhransferase (SHMT), methionine synthase (MS), methionine synthase reductase (MTRR) and cystathionine beta synthase (CBS) regulate key reactions in the folate and Hcy metabolism.	Folic Acid	174-180	serine hydroxymethyltransferase 1	Homo sapiens	4-34
24559276-3	2014	The serine hydroxymethyhransferase (SHMT), methionine synthase (MS), methionine synthase reductase (MTRR) and cystathionine beta synthase (CBS) regulate key reactions in the folate and Hcy metabolism.	Folic Acid	174-180	serine hydroxymethyltransferase 1	Homo sapiens	36-40
25422218-7	2014	Interaction analysis showed that the ORs only with FHIT methylation (OR=11.47) or only with HPV 16 positive (OR=4.63) or with serum folate level lower than 3.19ng/ml (OR=1.68) in SCC group were all higher than the control status of HPV 16 negative and FHIT unmethylation and serum folate level more than 3.19ng/ml (OR=1).	Folic Acid	132-138	serpin family B member 3	Homo sapiens	179-182
25422218-7	2014	Interaction analysis showed that the ORs only with FHIT methylation (OR=11.47) or only with HPV 16 positive (OR=4.63) or with serum folate level lower than 3.19ng/ml (OR=1.68) in SCC group were all higher than the control status of HPV 16 negative and FHIT unmethylation and serum folate level more than 3.19ng/ml (OR=1).	Folic Acid	281-287	serpin family B member 3	Homo sapiens	179-182
24745983-1	2014	This chapter focuses on the biology of the major facilitative membrane folate transporters, the reduced folate carrier (RFC), and the proton-coupled folate transporter (PCFT).	Folic Acid	71-77	solute carrier family 46 member 1	Homo sapiens	134-167
24745983-1	2014	This chapter focuses on the biology of the major facilitative membrane folate transporters, the reduced folate carrier (RFC), and the proton-coupled folate transporter (PCFT).	Folic Acid	71-77	solute carrier family 46 member 1	Homo sapiens	169-173
24745983-4	2014	PCFT mediates intestinal absorption of dietary folates.	Folic Acid	47-54	solute carrier family 46 member 1	Homo sapiens	0-4
24695276-1	2014	Folic acid (FA) is a water-soluble vitamin, and orally ingested FA is absorbed from the small intestine by the proton-coupled folate transporter (PCFT).	Folic Acid	0-10	solute carrier family 46 member 1	Homo sapiens	146-150
25863042-4	2014	Recently, there has been considerable interest in the protective role of folic acid (FA) against congenital anomalies via increasing the expression of ET-1.	Folic Acid	73-83	endothelin 1	Mus musculus	151-155
23623598-9	2014	Meanwhile, plasma CEA, NSE and SCC were negatively correlated with serum folate.	Folic Acid	73-79	serpin family B member 3	Homo sapiens	31-34
24165905-1	2013	Two kinds of thermally responsive polymers P(FAA-NIPA-co-AAm-co-ODA) and P(FPA-NIPA-co-AAm-co-ODA) containing folate, isopropyl acrylamide and octadecyl acrylate were fabricated through free radical random copolymerization for targeted drug delivery.	Folic Acid	110-116	zinc finger C3HC-type containing 1	Homo sapiens	79-83
23872009-3	2013	Folic acid for targeting cell membranes was bound to a TiO2/CdS/3-aminopropyltriethoxysilane film, and specific recognition of folic acid to targeting cells was achieved, leading to a significant decrease in ECL intensity.	Folic Acid	0-10	CDP-diacylglycerol synthase 1	Homo sapiens	60-63
23872009-3	2013	Folic acid for targeting cell membranes was bound to a TiO2/CdS/3-aminopropyltriethoxysilane film, and specific recognition of folic acid to targeting cells was achieved, leading to a significant decrease in ECL intensity.	Folic Acid	127-137	CDP-diacylglycerol synthase 1	Homo sapiens	60-63
23851396-1	2013	Folate receptors (FRalpha, FRbeta and FRgamma) are cysteine-rich cell-surface glycoproteins that bind folate with high affinity to mediate cellular uptake of folate.	Folic Acid	102-108	folate receptor alpha	Homo sapiens	0-45
23851396-1	2013	Folate receptors (FRalpha, FRbeta and FRgamma) are cysteine-rich cell-surface glycoproteins that bind folate with high affinity to mediate cellular uptake of folate.	Folic Acid	158-164	folate receptor alpha	Homo sapiens	0-45
23851396-2	2013	Although expressed at very low levels in most tissues, folate receptors, especially FRalpha, are expressed at high levels in numerous cancers to meet the folate demand of rapidly dividing cells under low folate conditions.	Folic Acid	55-61	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	84-91
23851396-2	2013	Although expressed at very low levels in most tissues, folate receptors, especially FRalpha, are expressed at high levels in numerous cancers to meet the folate demand of rapidly dividing cells under low folate conditions.	Folic Acid	154-160	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	84-91
23851396-3	2013	The folate dependency of many tumours has been therapeutically and diagnostically exploited by administration of anti-FRalpha antibodies, high-affinity antifolates, folate-based imaging agents and folate-conjugated drugs and toxins.	Folic Acid	4-10	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	118-125
23623989-4	2013	However, the effects of folate deficiency on the expression of NGF and NT-3 in brain tissue have not yet been investigated.	Folic Acid	24-30	neurotrophin 3	Mus musculus	71-75
23819524-3	2013	Because folate binds with high affinity to FR-beta, development of folate directed imaging agents has proceeded rapidly in the past decade.	Folic Acid	8-14	folate receptor beta	Homo sapiens	43-50
23819524-3	2013	Because folate binds with high affinity to FR-beta, development of folate directed imaging agents has proceeded rapidly in the past decade.	Folic Acid	67-73	folate receptor beta	Homo sapiens	43-50
23819524-9	2013	Moreover, both folate-PET imaging agents also bind to FR-alpha which is overexpressed on multiple human cancers.	Folic Acid	15-21	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	54-62
23726796-2	2013	In the folate pathway, TYMS catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate [5,10-CH2=THF, derived from tetrahydrofolate (THF)], as a cofactor.	Folic Acid	7-13	thymidylate synthetase	Homo sapiens	23-27
23936148-0	2013	Effect of folic acid supplementation on levels of circulating Monocyte Chemoattractant Protein-1 and the presence of intravascular ultrasound derived virtual histology thin-cap fibroatheromas in patients with stable angina pectoris.	Folic Acid	10-20	C-C motif chemokine ligand 2	Homo sapiens	62-96
23936148-2	2013	Monocyte Chemoattractant Protein-1 (MCP-1) is linked with coronary atherosclerosis and plaque instability and could potentially be modified by folic acid treatment.	Folic Acid	143-153	C-C motif chemokine ligand 2	Homo sapiens	0-34
23936148-2	2013	Monocyte Chemoattractant Protein-1 (MCP-1) is linked with coronary atherosclerosis and plaque instability and could potentially be modified by folic acid treatment.	Folic Acid	143-153	C-C motif chemokine ligand 2	Homo sapiens	36-41
23936148-6	2013	RESULTS: Patients treated with folic acid/vitamin B12 had a geometric mean (SD) MCP-1 level of 79.95 (1.49) versus 86.00 (1.43) pg/mL for patients receiving placebo (p-value 0.34).	Folic Acid	31-41	C-C motif chemokine ligand 2	Homo sapiens	80-85
32260920-6	2013	By conjugating folic acid to the surface of the coordination polymer spheres, the vehicles can be taken up selectively by cancer cells through cell surface receptor-mediated mechanisms.	Folic Acid	15-25	CD177 molecule	Homo sapiens	143-164
23806172-0	2013	Target delivery of MYCN siRNA by folate-nanoliposomes delivery system in a metastatic neuroblastoma model.	Folic Acid	33-39	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived	Mus musculus	19-23
23806172-3	2013	Fluorescence microscopy, TUNEL Assay, Quantitative RT-PCR and western blot were conducted to analysis the distribution of folate-nanoliposomes entrapped MYCN (V-myc myelocytomatosis viral related oncogene) siRNA in mice and the relevant suppression effect.	Folic Acid	122-128	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived	Mus musculus	153-157
23806172-4	2013	RESULTS: The folate-nanoliposomes entrapped MYCN siRNA can be specifically distributed in tumor tissues.	Folic Acid	13-19	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived	Mus musculus	44-48
23806172-5	2013	Further study shows that folate-nanoliposomes entrapped MYCN siRNA lead to MYCN mRNA expression significantly down-regulated (&gt;50%, and p &lt; 0.05) compared with negative control siRNA treatment.	Folic Acid	25-31	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived	Mus musculus	56-60
23806172-5	2013	Further study shows that folate-nanoliposomes entrapped MYCN siRNA lead to MYCN mRNA expression significantly down-regulated (&gt;50%, and p &lt; 0.05) compared with negative control siRNA treatment.	Folic Acid	25-31	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived	Mus musculus	75-79
23314538-2	2013	In the absence of systemic folate deficiency, the discovery of autoantibodies (AuAbs) to folate receptor alpha (FRalpha) that block the uptake of folate offers one mechanism to explain the response to folate in these disorders.	Folic Acid	89-95	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	112-119
23314538-3	2013	The association of FRalpha AuAbs with pregnancy-related complications, CFD syndrome, and autism spectrum disorders and response to folate therapy is highly suggestive of the involvement of these AuAbs in the disruption of brain development and function via folate pathways.	Folic Acid	257-263	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	19-26
23417011-2	2013	Using pyrosequencing, we developed methylation assays for the CpG islands (CGIs) and the CGI shore regions of the folate receptor alpha (FOLR1), proton-coupled folate transporter (PCFT) and reduced folate carrier 1 (RFC1) genes.	Folic Acid	114-120	folate receptor alpha	Homo sapiens	137-142
23417011-2	2013	Using pyrosequencing, we developed methylation assays for the CpG islands (CGIs) and the CGI shore regions of the folate receptor alpha (FOLR1), proton-coupled folate transporter (PCFT) and reduced folate carrier 1 (RFC1) genes.	Folic Acid	114-120	solute carrier family 46 member 1	Homo sapiens	180-184
23313509-1	2013	Proton-coupled folate transporter (PCFT), which is responsible for the intestinal uptake of folates and analogs, is expressed only in the proximal region in the small intestine.	Folic Acid	92-99	solute carrier family 46 member 1	Homo sapiens	0-33
23313509-1	2013	Proton-coupled folate transporter (PCFT), which is responsible for the intestinal uptake of folates and analogs, is expressed only in the proximal region in the small intestine.	Folic Acid	92-99	solute carrier family 46 member 1	Homo sapiens	35-39
23374533-9	2013	Melatonin, folic acid or their combination also restored the baseline levels of IFN-gamma and Akt1 mRNA expression.	Folic Acid	11-21	interferon gamma	Rattus norvegicus	80-89
23336575-1	2013	OBJECTIVE: Polymorphisms that reduce the activity of reduced folate carrier (RFC) and methylenetetrahydrofolate reductase (MTHFR) and double (2R2R) or triple (3R3R) 28-bp tandem repeats in the promoter region of thymidylate synthase (TS) have been associated with the risk of childhood acute leukemia (AL).	Folic Acid	61-67	thymidylate synthetase	Homo sapiens	212-232
23336575-1	2013	OBJECTIVE: Polymorphisms that reduce the activity of reduced folate carrier (RFC) and methylenetetrahydrofolate reductase (MTHFR) and double (2R2R) or triple (3R3R) 28-bp tandem repeats in the promoter region of thymidylate synthase (TS) have been associated with the risk of childhood acute leukemia (AL).	Folic Acid	61-67	thymidylate synthetase	Homo sapiens	234-236
23081874-15	2013	WIDER IMPLICATIONS OF THE FINDINGS: If confirmed in subsequent studies, DNMT3B promoter polymorphisms might be additional markers to be taken into account when evaluating the contribution of one-carbon (folate) metabolism to the maternal risk of birth of a child with DS.	Folic Acid	203-209	DNA methyltransferase 3 beta	Homo sapiens	72-78
23194289-0	2013	Self-assembly of folate onto polyethyleneimine-coated CdS/ZnS quantum dots for targeted turn-on fluorescence imaging of folate receptor overexpressed cancer cells.	Folic Acid	17-23	CDP-diacylglycerol synthase 1	Homo sapiens	54-57
23151531-6	2013	The same pattern was observed in relation to RBC folate in the cord blood at birth: IGF2 (P = 0.038), PEG3 (P &lt; 0.001), and LINE-1 (P &lt; 0.001).	Folic Acid	49-55	insulin like growth factor 2	Homo sapiens	84-88
23151531-6	2013	The same pattern was observed in relation to RBC folate in the cord blood at birth: IGF2 (P = 0.038), PEG3 (P &lt; 0.001), and LINE-1 (P &lt; 0.001).	Folic Acid	49-55	paternally expressed 3	Homo sapiens	102-106
23828504-5	2013	Loss of folate receptor-alpha-expressing cerebrospinal fluid exosomes correlates with severely reduced 5-methyltetrahydrofolate concentration, corroborating the importance of the folate receptor-alpha-mediated folate transport in the cerebrospinal fluid.	Folic Acid	8-14	folate receptor alpha	Homo sapiens	179-200
22954694-2	2012	PCFT was identified in 2006 as the primary transporter for intestinal absorption of dietary folates, as mutations in PCFT are causal in hereditary folate malabsorption (HFM) syndrome.	Folic Acid	92-99	solute carrier family 46 member 1	Homo sapiens	0-4
22954694-2	2012	PCFT was identified in 2006 as the primary transporter for intestinal absorption of dietary folates, as mutations in PCFT are causal in hereditary folate malabsorption (HFM) syndrome.	Folic Acid	92-99	solute carrier family 46 member 1	Homo sapiens	117-121
22307944-1	2012	Thymidylate synthase (TS) is an important enzyme involved in folate metabolism and catalyzes methylation of deoxyuridine monophosphate to deoxythymidine monophosphate, which is essential for DNA replication.	Folic Acid	61-67	thymidylate synthetase	Homo sapiens	0-20
22307944-1	2012	Thymidylate synthase (TS) is an important enzyme involved in folate metabolism and catalyzes methylation of deoxyuridine monophosphate to deoxythymidine monophosphate, which is essential for DNA replication.	Folic Acid	61-67	thymidylate synthetase	Homo sapiens	22-24
22943049-1	2012	A competitive binding assay based on localized surface plasmon resonance (LSPR) of folic acid-functionalized gold nanoparticles (FA-AuNPs) and human dihydrofolate reductase enzyme (hDHFR) was developed to detect nanomolar to micromolar concentrations of the widely applied anti-cancer drug, methotrexate (MTX).	Folic Acid	83-93	dihydrofolate reductase	Homo sapiens	181-186
23019356-0	2012	Folate binding site of flavin-dependent thymidylate synthase.	Folic Acid	0-6	thymidylate synthetase	Homo sapiens	40-60
23552283-1	2013	The proton-coupled folate transporter (PCFT, SLC46A1) mediates folate transport across the apical brush-border membrane of the proximal small intestine and the basolateral membrane of choroid plexus ependymal cells.	Folic Acid	19-25	solute carrier family 46 member 1	Homo sapiens	39-43
23552283-1	2013	The proton-coupled folate transporter (PCFT, SLC46A1) mediates folate transport across the apical brush-border membrane of the proximal small intestine and the basolateral membrane of choroid plexus ependymal cells.	Folic Acid	19-25	solute carrier family 46 member 1	Homo sapiens	45-52
26022931-4	2015	Dihydrofolate reductase (DHFR) plays a critical role in regulating the metabolism of folate.	Folic Acid	7-13	dihydrofolate reductase	Homo sapiens	25-29
25959374-0	2015	Folic acid administration inhibits amyloid beta-peptide accumulation in APP/PS1 transgenic mice.	Folic Acid	0-10	presenilin 1	Mus musculus	76-79
23467813-10	2013	RESULTS: Folate plus vitamin B12 improved negative symptoms significantly compared with placebo (group difference, -0.33 change in SANS score per week; 95% CI, -0.62 to -0.05) when genotype was taken into account but not when genotype was excluded.	Folic Acid	9-15	USH1 protein network component sans	Homo sapiens	131-135
23412628-1	2013	PURPOSE: We examined whether the novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate, compound 2, might be an effective treatment for malignant pleural mesothelioma (MPM), reflecting its selective membrane transport by the proton-coupled folate transport (PCFT) over the reduced folate carrier (RFC).	Folic Acid	91-97	solute carrier family 46 member 1	Homo sapiens	269-273
25959374-3	2015	We hypothesized that folic acid acts through an epigenetic gene silencing mechanism to lower Abeta levels in the APP/PS1 transgenic mouse model of AD.	Folic Acid	21-31	amyloid beta (A4) precursor protein	Mus musculus	93-98
25959374-3	2015	We hypothesized that folic acid acts through an epigenetic gene silencing mechanism to lower Abeta levels in the APP/PS1 transgenic mouse model of AD.	Folic Acid	21-31	amyloid beta (A4) precursor protein	Mus musculus	113-120
23421317-0	2013	DHFR 19-bp deletion and SHMT C1420T polymorphisms and metabolite concentrations of the folate pathway in individuals with Down syndrome.	Folic Acid	87-93	dihydrofolate reductase	Homo sapiens	0-4
23421317-0	2013	DHFR 19-bp deletion and SHMT C1420T polymorphisms and metabolite concentrations of the folate pathway in individuals with Down syndrome.	Folic Acid	87-93	serine hydroxymethyltransferase 1	Homo sapiens	24-28
25959374-9	2015	Folate deficiency elevated hippocampal APP, PS1 and Abeta protein levels, and these rises were prevented by folic acid.	Folic Acid	108-118	presenilin 1	Mus musculus	44-47
23421317-3	2013	AIM: Investigate the association between Dihydrofolate reductase (DHFR) 19-base pair (bp) deletion and Serine hydroxymethyltransferase (SHMT) C1420T polymorphisms and serum folate and plasma Hcy and methylmalonic acid (MMA) concentrations in 85 individuals with DS.	Folic Acid	48-54	dihydrofolate reductase	Homo sapiens	66-70
23421317-3	2013	AIM: Investigate the association between Dihydrofolate reductase (DHFR) 19-base pair (bp) deletion and Serine hydroxymethyltransferase (SHMT) C1420T polymorphisms and serum folate and plasma Hcy and methylmalonic acid (MMA) concentrations in 85 individuals with DS.	Folic Acid	48-54	serine hydroxymethyltransferase 1	Homo sapiens	103-134
23421317-3	2013	AIM: Investigate the association between Dihydrofolate reductase (DHFR) 19-base pair (bp) deletion and Serine hydroxymethyltransferase (SHMT) C1420T polymorphisms and serum folate and plasma Hcy and methylmalonic acid (MMA) concentrations in 85 individuals with DS.	Folic Acid	48-54	serine hydroxymethyltransferase 1	Homo sapiens	136-140
25959374-9	2015	Folate deficiency elevated hippocampal APP, PS1 and Abeta protein levels, and these rises were prevented by folic acid.	Folic Acid	108-118	amyloid beta (A4) precursor protein	Mus musculus	52-57
23421317-6	2013	RESULTS: Individuals with DHFR DD/SHMT TT genotypes presented increased folate concentrations (p=0.004) and the DHFR II/SHMT TT genotypes were associated with increased MMA concentrations (p=0.008).	Folic Acid	72-78	dihydrofolate reductase	Homo sapiens	26-30
23421317-6	2013	RESULTS: Individuals with DHFR DD/SHMT TT genotypes presented increased folate concentrations (p=0.004) and the DHFR II/SHMT TT genotypes were associated with increased MMA concentrations (p=0.008).	Folic Acid	72-78	serine hydroxymethyltransferase 1	Homo sapiens	34-38
23421317-8	2013	CONCLUSION: There is an association between DHFR DD/SHMT TT and DHFR II/SHMT TT combined genotypes and folate and MMA concentrations in individuals with DS.	Folic Acid	103-109	dihydrofolate reductase	Homo sapiens	44-48
25959374-10	2015	In conclusion, these findings are consistent with a mechanism in which folic acid increases methylation potential and DNMT activity, modifies DNA methylation and ultimately decreases APP, PS1 and Abeta protein levels.	Folic Acid	71-81	presenilin 1	Mus musculus	188-191
23421317-8	2013	CONCLUSION: There is an association between DHFR DD/SHMT TT and DHFR II/SHMT TT combined genotypes and folate and MMA concentrations in individuals with DS.	Folic Acid	103-109	serine hydroxymethyltransferase 1	Homo sapiens	52-56
23421317-8	2013	CONCLUSION: There is an association between DHFR DD/SHMT TT and DHFR II/SHMT TT combined genotypes and folate and MMA concentrations in individuals with DS.	Folic Acid	103-109	dihydrofolate reductase	Homo sapiens	64-68
25959374-10	2015	In conclusion, these findings are consistent with a mechanism in which folic acid increases methylation potential and DNMT activity, modifies DNA methylation and ultimately decreases APP, PS1 and Abeta protein levels.	Folic Acid	71-81	amyloid beta (A4) precursor protein	Mus musculus	196-201
23421317-8	2013	CONCLUSION: There is an association between DHFR DD/SHMT TT and DHFR II/SHMT TT combined genotypes and folate and MMA concentrations in individuals with DS.	Folic Acid	103-109	serine hydroxymethyltransferase 1	Homo sapiens	72-76
26147304-8	2015	In addition, we found the RAN rs14035 CC genotype was related to a decreased risk of CRC with respect to tumor size and metabolism of homocysteine and folate.	Folic Acid	151-157	RAN, member RAS oncogene family	Homo sapiens	26-29
23255615-0	2013	EGFR activity is required for renal tubular cell dedifferentiation and proliferation in a murine model of folic acid-induced acute kidney injury.	Folic Acid	106-116	epidermal growth factor receptor	Mus musculus	0-4
25877470-2	2015	Recent attention focused on exploiting hPCFT for targeting solid tumours with novel cytotoxic anti-folates.	Folic Acid	99-106	solute carrier family 46 member 1	Homo sapiens	39-44
23404871-13	2013	Effect measure modification was observed between the 28-bp VNTR and combined folate intake for CP with an OR of 10.0 (1.6-60.9).	Folic Acid	77-83	calmodulin like 3	Homo sapiens	95-97
25841994-0	2015	Folic acid mediates activation of the pro-oncogene STAT3 via the Folate Receptor alpha.	Folic Acid	0-10	folate receptor alpha	Homo sapiens	65-86
22785121-0	2012	Identification of a functionally critical GXXG motif and its relationship to the folate binding site of the proton-coupled folate transporter (PCFT-SLC46A1).	Folic Acid	81-87	solute carrier family 46 member 1	Homo sapiens	143-147
25841994-5	2015	We show here that folic acid and folinic acid can activate STAT3 through FRalpha in a Janus Kinase (JAK)-dependent manner, and we demonstrate that gp130 functions as a transducing receptor for this signalling.	Folic Acid	18-28	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	73-80
22785121-0	2012	Identification of a functionally critical GXXG motif and its relationship to the folate binding site of the proton-coupled folate transporter (PCFT-SLC46A1).	Folic Acid	81-87	solute carrier family 46 member 1	Homo sapiens	148-155
22785121-1	2012	The proton-coupled folate transporter (PCFT) mediates intestinal folate absorption, and loss-of-function mutations in this gene result in the autosomal recessive disorder hereditary folate malabsorption.	Folic Acid	19-25	solute carrier family 46 member 1	Homo sapiens	39-43
25841994-5	2015	We show here that folic acid and folinic acid can activate STAT3 through FRalpha in a Janus Kinase (JAK)-dependent manner, and we demonstrate that gp130 functions as a transducing receptor for this signalling.	Folic Acid	18-28	interleukin 6 cytokine family signal transducer	Homo sapiens	147-152
22785121-6	2012	Both I188C and M193C mutants were functional and were inhibited by membrane-impermeable sulfhydryl-reactive reagents; this could be prevented with PCFT substrate, but the protection was sustained at 0 C only for the I188C mutant, consistent with localization of Ile-188 in the PCFT folate binding pocket.	Folic Acid	282-288	solute carrier family 46 member 1	Homo sapiens	147-151
22785121-6	2012	Both I188C and M193C mutants were functional and were inhibited by membrane-impermeable sulfhydryl-reactive reagents; this could be prevented with PCFT substrate, but the protection was sustained at 0 C only for the I188C mutant, consistent with localization of Ile-188 in the PCFT folate binding pocket.	Folic Acid	282-288	solute carrier family 46 member 1	Homo sapiens	277-281
25841994-6	2015	Moreover, folic acid can promote dose dependent cell proliferation in FRalpha-positive HeLa cells, but not in FRalpha-negative HEK293 cells.	Folic Acid	10-20	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	70-77
25841994-8	2015	The identification of this FRalpha-STAT3 signal transduction pathway activated by folic and folinic acid contributes to the understanding of the involvement of folic acid in preventing neural tube defects as well as in tumour growth.	Folic Acid	82-87	folate receptor alpha	Homo sapiens	27-40
23129207-2	2013	This report describes a deficiency in N utilization in an Arabidopsis (Arabidopsis thaliana) transfer DNA insertion mutant of the mitochondrial folylpolyglutamate synthetase gene DFC, which catalyzes the conjugation of glutamate residues to the tetrahydrofolate during folate synthesis.	Folic Acid	255-261	DHFS-FPGS homolog C	Arabidopsis thaliana	179-182
25841994-8	2015	The identification of this FRalpha-STAT3 signal transduction pathway activated by folic and folinic acid contributes to the understanding of the involvement of folic acid in preventing neural tube defects as well as in tumour growth.	Folic Acid	160-170	folate receptor alpha	Homo sapiens	27-40
23129207-8	2013	These results indicate that DFC is required for N utilization in Arabidopsis and provide new insight into a potential interaction between folate and N metabolism.	Folic Acid	138-144	DHFS-FPGS homolog C	Arabidopsis thaliana	28-31
25841994-10	2015	Our finding that folic acid can activate STAT3 via FRalpha adds complexity to the established roles of B9 vitamins in cancer and neural tube defects.	Folic Acid	17-27	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	51-58
26131691-14	2015	In this low-dose regime, folate supplements are given to mitigate side effects by bypassing the biochemical requirement for DHFR.	Folic Acid	25-31	dihydrofolate reductase	Homo sapiens	124-128
22648968-7	2012	In a subgroup of 167 mothers with data on prenatal intake of supplements containing folic acid (a synthetic form of folate), DHFR19bpdel-associated risk was elevated significantly only among those who reported taking folic acid supplements.	Folic Acid	84-94	dihydrofolate reductase	Homo sapiens	125-129
22648968-7	2012	In a subgroup of 167 mothers with data on prenatal intake of supplements containing folic acid (a synthetic form of folate), DHFR19bpdel-associated risk was elevated significantly only among those who reported taking folic acid supplements.	Folic Acid	116-122	dihydrofolate reductase	Homo sapiens	125-129
22648968-7	2012	In a subgroup of 167 mothers with data on prenatal intake of supplements containing folic acid (a synthetic form of folate), DHFR19bpdel-associated risk was elevated significantly only among those who reported taking folic acid supplements.	Folic Acid	217-227	dihydrofolate reductase	Homo sapiens	125-129
22869901-0	2012	Dietary folic acid promotes survival of Foxp3+ regulatory T cells in the colon.	Folic Acid	8-18	forkhead box P3	Mus musculus	40-45
22869901-2	2012	In this study, we report that dietary folic acid (FA) is required for the maintenance of Foxp3+ regulatory T cells (Tregs) in the colon.	Folic Acid	38-48	forkhead box P3	Mus musculus	89-94
22869901-4	2012	Blockade of folate receptor 4 and treatment with methotrexate, which inhibits folate metabolic pathways, decreased colonic Foxp3+ Tregs.	Folic Acid	12-18	forkhead box P3	Mus musculus	123-128
22648968-9	2012	CONCLUSIONS: Maternal homozygosity for a polymorphism in the DHFR gene necessary for converting synthetic folic acid into biologic folate was associated with an increased risk for retinoblastoma.	Folic Acid	106-116	dihydrofolate reductase	Homo sapiens	61-65
22648968-9	2012	CONCLUSIONS: Maternal homozygosity for a polymorphism in the DHFR gene necessary for converting synthetic folic acid into biologic folate was associated with an increased risk for retinoblastoma.	Folic Acid	131-137	dihydrofolate reductase	Homo sapiens	61-65
25860940-0	2015	MYCN amplification confers enhanced folate dependence and methotrexate sensitivity in neuroblastoma.	Folic Acid	36-42	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	0-4
24552105-5	2012	Epigenetic mechanisms of folate deficiency are illustrated by inheritance of coat colour of agouti mice model and altered expression of Igf2/H19 imprinting genes.	Folic Acid	25-31	insulin-like growth factor 2	Mus musculus	136-140
22496243-8	2012	When shRNA knocked down hcp1 mRNA, heme-(55)Fe uptake and [(3)H]folate transport mirrored the mRNA decrease, ho1 mRNA increased, and flvcr mRNA was unchanged.	Folic Acid	64-70	solute carrier family 46 member 1	Homo sapiens	24-28
22496243-9	2012	These data argue that HCP1 is involved in low-affinity heme-Fe uptake not just in folate transport.	Folic Acid	82-88	solute carrier family 46 member 1	Homo sapiens	22-26
24552105-6	2012	Dietary exposure to fumonisin FB1 acts synergistically with folate deficiency on alterations of heterochromatin assembly.	Folic Acid	60-66	TCF3 (E2A) fusion partner	Mus musculus	30-33
25860940-2	2015	We have identified folate-mediated one-carbon metabolism as highly upregulated in neuroblastoma tumors with MYCN amplification and have validated this finding experimentally by showing that MYCN amplified neuroblastoma cell lines have a higher requirement for folate and are significantly more sensitive to the antifolate methotrexate than cell lines without MYCN amplification.	Folic Acid	19-25	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	108-112
24552105-7	2012	Deficiency in folate and vitamin B12 produces impaired fatty acid oxidation in liver and heart through imbalanced methylation and acetylation of PGC1-alpha and decreased expression of SIRT1, and long-lasting cognitive disabilities through impaired hippocampal cell proliferation, differentiation and plasticity and atrophy of hippocampal CA1.	Folic Acid	14-20	sirtuin 1	Mus musculus	184-189
24552105-7	2012	Deficiency in folate and vitamin B12 produces impaired fatty acid oxidation in liver and heart through imbalanced methylation and acetylation of PGC1-alpha and decreased expression of SIRT1, and long-lasting cognitive disabilities through impaired hippocampal cell proliferation, differentiation and plasticity and atrophy of hippocampal CA1.	Folic Acid	14-20	carbonic anhydrase 1	Mus musculus	338-341
22484375-6	2012	The elevate expression of dihydrofolate reductase and thymidylate synthase, two E2F1-target genes involved in folate metabolism and required for G(1) progression, favored dTTP accumulation, which promoted DNA single strand breaks and the subsequent activation of Chk1.	Folic Acid	33-39	thymidylate synthetase	Homo sapiens	54-74
22484375-6	2012	The elevate expression of dihydrofolate reductase and thymidylate synthase, two E2F1-target genes involved in folate metabolism and required for G(1) progression, favored dTTP accumulation, which promoted DNA single strand breaks and the subsequent activation of Chk1.	Folic Acid	33-39	E2F transcription factor 1	Homo sapiens	80-84
22037925-0	2012	Involvement of PI3K, GSK-3beta and PPARgamma in the antidepressant-like effect of folic acid in the forced swimming test in mice.	Folic Acid	82-92	glycogen synthase kinase 3 beta	Mus musculus	21-30
22037925-10	2012	These results indicate that the antidepressant-like effect of folic acid in the FST might be dependent on inhibition of GSK-3beta and activation of PPARgamma, reinforcing the notion that these are important targets for antidepressant activity.	Folic Acid	62-72	glycogen synthase kinase 3 beta	Mus musculus	120-129
25860940-2	2015	We have identified folate-mediated one-carbon metabolism as highly upregulated in neuroblastoma tumors with MYCN amplification and have validated this finding experimentally by showing that MYCN amplified neuroblastoma cell lines have a higher requirement for folate and are significantly more sensitive to the antifolate methotrexate than cell lines without MYCN amplification.	Folic Acid	19-25	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	190-194
25860940-2	2015	We have identified folate-mediated one-carbon metabolism as highly upregulated in neuroblastoma tumors with MYCN amplification and have validated this finding experimentally by showing that MYCN amplified neuroblastoma cell lines have a higher requirement for folate and are significantly more sensitive to the antifolate methotrexate than cell lines without MYCN amplification.	Folic Acid	19-25	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	190-194
25866054-0	2015	Ovarian cancer immunotherapy using PD-L1 siRNA targeted delivery from folic acid-functionalized polyethylenimine: strategies to enhance T cell killing.	Folic Acid	70-80	CD274 molecule	Homo sapiens	35-40
22537194-3	2012	Pemetrexed (Alimta , MTA) is a multitarget antifolate that inhibits folate-dependent enzymes: thymidylate synthase, dihydrofolate reductase and glycinamide ribonucleotide formyltransferase, required for de novo synthesis of nucleotides for DNA replication.	Folic Acid	47-53	thymidylate synthetase	Homo sapiens	94-114
23136681-13	2004	synthesized two conjugates, [(18)F]-5 and [(18)F]-8, by conjugating [(18)F]FDG with folate and methotrexate (MTX), respectively, using the readily available oxime-reactive [(18)F]FDG building block (1).	Folic Acid	84-90	metaxin 1	Homo sapiens	109-112
23136681-17	2004	MTX is a folic acid analog but possesses a relatively low affinity for folate receptor.	Folic Acid	9-19	metaxin 1	Homo sapiens	0-3
25866054-3	2015	This study aims to block PD-1/PD-L1 interactions by delivering PD-L1 siRNA, using various folic acid (FA)-functionalized polyethylenimine (PEI) polymers, to SKOV-3-Luc EOC cells, and investigate the sensitization of the EOC cells to T cell killing.	Folic Acid	90-100	CD274 molecule	Homo sapiens	30-35
25866054-3	2015	This study aims to block PD-1/PD-L1 interactions by delivering PD-L1 siRNA, using various folic acid (FA)-functionalized polyethylenimine (PEI) polymers, to SKOV-3-Luc EOC cells, and investigate the sensitization of the EOC cells to T cell killing.	Folic Acid	90-100	CD274 molecule	Homo sapiens	63-68
25948668-9	2015	CONCLUSIONS: We identified novel associations between SNPs in CD320 and DNMT2, which had been previously associated with neural tube defects, and vitamin B-12 status, as well as between SNPs in SHMT1, which had been previously associated with colorectal cancer and cardiovascular disease risk, and RBC folate status.	Folic Acid	302-308	CD320 molecule	Homo sapiens	62-67
22674380-3	2012	We obtained that the different biological processes of ABCB1 inhibited transport and signal network repressed carbon dioxide transport, ER to Golgi vesicle-mediated transport, folic acid transport, mitochondrion transport along microtubule, water transport, BMP signaling pathway, Ras protein signal transduction, transforming growth factor beta receptor signaling pathway in chimpanzee compared with the inhibited network of the human left cerebrum, as a result of inducing inhibition of mitochondrion transport along microtubule and BMP signal-induced cell shape in chimpanzee left cerebrum.	Folic Acid	176-186	bone morphogenetic protein 1	Homo sapiens	535-538
22325970-5	2012	Quantitative methylated DNA immunoprecipitation (qMeDIP) and quantitative methylated specific PCR (qMSP) analysis of methylation status showed that folate treatment, increased the methylation level of DNA repeat elements in tumour and in colorectal tissue and that of MGMT and specific oncogenes (PDGF-B or survivin) in tumours (but not in colorectal tissue), but had no effect on the expression of tumour suppressor genes (p53, PTENorbax) in tumours or in colorectal tissue.	Folic Acid	148-154	platelet derived growth factor, B polypeptide	Mus musculus	297-303
22576918-1	2012	Thymidylate synthase (TS) is a crucial enzyme in  folate metabolism and plays a vital role in DNA synthesis and repair.	Folic Acid	50-56	thymidylate synthetase	Homo sapiens	0-20
22576918-1	2012	Thymidylate synthase (TS) is a crucial enzyme in  folate metabolism and plays a vital role in DNA synthesis and repair.	Folic Acid	50-56	thymidylate synthetase	Homo sapiens	22-24
22179615-2	2012	The acidic pH optimum for PCFT is relevant to intestinal absorption of folates and could afford a means of selectively targeting tumors with novel cytotoxic antifolates.	Folic Acid	71-78	solute carrier family 46 member 1	Homo sapiens	26-30
22325970-5	2012	Quantitative methylated DNA immunoprecipitation (qMeDIP) and quantitative methylated specific PCR (qMSP) analysis of methylation status showed that folate treatment, increased the methylation level of DNA repeat elements in tumour and in colorectal tissue and that of MGMT and specific oncogenes (PDGF-B or survivin) in tumours (but not in colorectal tissue), but had no effect on the expression of tumour suppressor genes (p53, PTENorbax) in tumours or in colorectal tissue.	Folic Acid	148-154	transformation related protein 53, pseudogene	Mus musculus	424-427
22179615-5	2012	By transiently expressing PCFT in reduced folate carrier- and PCFT-null HeLa (R1-11) cells and chemical cross-linking with 1,1-methanediyl bismethanethiosulfonate and Western blotting, PCFT species with molecular masses approximating those of the PCFT dimer and higher order oligomers were detected.	Folic Acid	42-48	solute carrier family 46 member 1	Homo sapiens	26-30
22179615-11	2012	Better understanding of these higher order PCFT structures may lead to therapeutic applications related to folate uptake in hereditary folate malabsorption, and delivery of PCFT-targeted chemotherapy drugs for cancer.	Folic Acid	107-113	solute carrier family 46 member 1	Homo sapiens	43-47
26090596-1	2015	Folate receptors alpha (FRalpha) and beta (FRbeta) are two isoforms of the cell surface glycoprotein that binds folate.	Folic Acid	112-118	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	24-31
22037183-0	2012	Differences in folate-protein interactions result in differing inhibition of native rat liver and recombinant glycine N-methyltransferase by 5-methyltetrahydrofolate.	Folic Acid	15-21	glycine N-methyltransferase	Rattus norvegicus	110-137
22037183-8	2012	We show that in the folate-GNMT complexes with the native enzyme, two folate molecules establish three and four hydrogen bonds with the protein.	Folic Acid	20-26	glycine N-methyltransferase	Rattus norvegicus	27-31
22037183-8	2012	We show that in the folate-GNMT complexes with the native enzyme, two folate molecules establish three and four hydrogen bonds with the protein.	Folic Acid	70-76	glycine N-methyltransferase	Rattus norvegicus	27-31
22706342-14	2012	Here we show that the methylation status and mRNA levels of Esr1 were decreased (P= 0.021, P= 0.045, respectively), while the Cdh1 and Pgr expression levels were slightly but not significantly elevated and the methylation status did not vary in the folate-deficient mice compared with the wild type.	Folic Acid	249-255	estrogen receptor 1 (alpha)	Mus musculus	60-64
26090596-1	2015	Folate receptors alpha (FRalpha) and beta (FRbeta) are two isoforms of the cell surface glycoprotein that binds folate.	Folic Acid	112-118	folate receptor beta	Homo sapiens	43-49
22037183-9	2012	In the folate-recombinant GNMT complex only one hydrogen bond is established.	Folic Acid	7-13	glycine N-methyltransferase	Rattus norvegicus	26-30
22037183-10	2012	This difference results in more effective inhibition by folate of the native liver GNMT activity compared to the recombinant enzyme.	Folic Acid	56-62	glycine N-methyltransferase	Rattus norvegicus	83-87
25747036-5	2015	In terms of micronutrient transport, ascorbic acid, folate and other essential factors are transported by specific (cloned) carriers across CP into ventricular CSF, from which they penetrate across the ependyma and pia mater deeply into the brain to support its viability and function.	Folic Acid	52-58	colony stimulating factor 2	Homo sapiens	160-163
22061491-5	2012	In particular, animal studies using the in situ rat C6 glioma model showed that the folate-targeted co-delivery of BCL-2 siRNA and DOX caused not only an obvious down-regulation of the anti-apoptotic BCL-2 gene but also a remarkable up-regulation of the pro-apoptotic Bax gene, resulting in the significantly elevated level of caspase-3 activation and remarkable cell apoptosis in tumor tissues.	Folic Acid	84-90	BCL2 associated X, apoptosis regulator	Rattus norvegicus	268-271
22814109-1	2012	High affinity folate binding protein (FBP) regulates as a soluble protein and as a cellular receptor intracellular trafficking of folic acid, a vitamin of great importance to cell growth and division.	Folic Acid	130-140	folate receptor beta	Homo sapiens	38-41
26191275-3	2015	The fact that FRalpha, which is known to be needed extremely by the cells of malignancies that proliferate rapidly, is present in limited amounts in normal tissues while it is overexpressed in malignant cells of the same tissues makes folate a candidate for target molecular therapy.	Folic Acid	235-241	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	14-21
22855837-3	2012	By conjugating the ligand folate with a fluorescent contrast agent, fluorescein isothiocyanate (FITC), we aimed to explore the potential role of FR-beta fluorescence imaging in the distinction of vulnerable sites from more stable regions.	Folic Acid	26-32	folate receptor beta	Homo sapiens	145-152
22855837-11	2012	These characteristics of vulnerability imply that molecular imaging of FR-beta through folate conjugates might be a good indicator for plaque vulnerability in future noninvasive imaging studies.	Folic Acid	87-93	folate receptor beta	Homo sapiens	71-78
22170255-3	2012	Guided by molecular modelling calculations and structure-activity relationships we conjugated at C9 of noscapine, a folate group-a ligand for cellular folate receptor alpha (FRalpha).	Folic Acid	116-122	folate receptor alpha	Homo sapiens	151-172
22100631-0	2012	Alcohol intake and folate antagonism via CYP2E1 and ALDH1: effects on oral carcinogenesis.	Folic Acid	19-25	aldehyde dehydrogenase 1 family member A1	Homo sapiens	52-57
22100631-11	2012	There are also two enzymes within the ALDH1 family that play an important role both in ethanol metabolism and the folate one-carbon pathway.	Folic Acid	114-120	aldehyde dehydrogenase 1 family member A1	Homo sapiens	38-43
22100631-16	2012	Our second hypothesis is that folate interacts with one of these response elements to upregulate ALDH1A1 and ALDH1L1 expression in order to decrease acetaldehyde concentrations and promote DNA stability, thereby decreasing cancer susceptibility.	Folic Acid	30-36	aldehyde dehydrogenase 1 family member A1	Homo sapiens	97-104
25656965-2	2015	Polymorphisms in the DNA Methyltransferase 3B (DNMT3B) gene, one of the crucial gene of the folate metabolism, affects the activity of the enzyme and increases the susceptibility of nondisjunction in mothers of Down syndrome children (MDS).	Folic Acid	92-98	DNA methyltransferase 3 beta	Homo sapiens	21-45
22369260-7	2012	Another analytical application of bovine FBP is in affinity chromatography, as a clean-up/concentration step for analysis of folates in foods and biological samples by liquid chromatographic methods.	Folic Acid	125-132	folate receptor alpha	Bos taurus	41-44
22369260-9	2012	Since the initial reports of FBP in cow"s milk, its physiological role has been discussed, especially regarding its effects on folate absorption from milk and dairy products.	Folic Acid	127-133	folate receptor alpha	Bos taurus	29-32
22586289-1	2012	Cerebral folate transport deficiency is an inherited brain-specific folate transport defect that is caused by mutations in the folate receptor 1 gene coding for folate receptor alpha (FRalpha).	Folic Acid	9-15	folate receptor alpha	Homo sapiens	127-144
22586289-1	2012	Cerebral folate transport deficiency is an inherited brain-specific folate transport defect that is caused by mutations in the folate receptor 1 gene coding for folate receptor alpha (FRalpha).	Folic Acid	9-15	folate receptor alpha	Homo sapiens	161-182
22586289-1	2012	Cerebral folate transport deficiency is an inherited brain-specific folate transport defect that is caused by mutations in the folate receptor 1 gene coding for folate receptor alpha (FRalpha).	Folic Acid	9-15	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	184-191
25656965-2	2015	Polymorphisms in the DNA Methyltransferase 3B (DNMT3B) gene, one of the crucial gene of the folate metabolism, affects the activity of the enzyme and increases the susceptibility of nondisjunction in mothers of Down syndrome children (MDS).	Folic Acid	92-98	DNA methyltransferase 3 beta	Homo sapiens	47-53
22209480-0	2012	Effect of folic acid supplementation on the progression of carotid intima-media thickness: a meta-analysis of randomized controlled trials.	Folic Acid	10-20	CIMT	Homo sapiens	59-89
23328702-2	2012	We determined whether supplementation with physiological doses of folate could alter methylation in the oestrogen receptor 1 (ESR1) and mutL homolog 1 (MLH1) genes in colonic mucosa of subjects with colorectal adenoma.	Folic Acid	66-72	mutL homolog 1	Homo sapiens	136-150
23328702-2	2012	We determined whether supplementation with physiological doses of folate could alter methylation in the oestrogen receptor 1 (ESR1) and mutL homolog 1 (MLH1) genes in colonic mucosa of subjects with colorectal adenoma.	Folic Acid	66-72	mutL homolog 1	Homo sapiens	152-156
22209480-1	2012	OBJECTIVES: We conducted a meta-analysis of relevant randomized trials to assess whether folic acid supplementation reduces the progression of atherosclerosis as measured by carotid intima-media thickness (CIMT).	Folic Acid	89-99	CIMT	Homo sapiens	174-204
22209480-1	2012	OBJECTIVES: We conducted a meta-analysis of relevant randomized trials to assess whether folic acid supplementation reduces the progression of atherosclerosis as measured by carotid intima-media thickness (CIMT).	Folic Acid	89-99	CIMT	Homo sapiens	206-210
22209480-9	2012	CONCLUSIONS: Our findings indicate that folic acid supplementation is effective in reducing the progression of CIMT, particularly in subjects with CKD or high CVD risk and among trials with higher baseline CIMT levels or a larger homocysteine reduction.	Folic Acid	40-50	CIMT	Homo sapiens	111-115
22209480-9	2012	CONCLUSIONS: Our findings indicate that folic acid supplementation is effective in reducing the progression of CIMT, particularly in subjects with CKD or high CVD risk and among trials with higher baseline CIMT levels or a larger homocysteine reduction.	Folic Acid	40-50	CIMT	Homo sapiens	206-210
22461522-0	2012	Folate deprivation enhances invasiveness of human colon cancer cells mediated by activation of sonic hedgehog signaling through promoter hypomethylation and cross action with transcription nuclear factor-kappa B pathway.	Folic Acid	0-6	sonic hedgehog signaling molecule	Homo sapiens	95-109
22461522-3	2012	The aims of this study were to investigate whether and how folate deprivation promotes invasion by colon cancer cells in relation to Shh signaling and NF-kappaB pathway activation.	Folic Acid	59-65	sonic hedgehog signaling molecule	Homo sapiens	133-136
22461522-9	2012	Taken together, these findings demonstrate that folate deprivation enhanced invasiveness of colon cancer cells mediated by activation of Shh signaling through promoter hypomethylation and cross actions with the NF-kappaB pathway.	Folic Acid	48-54	sonic hedgehog signaling molecule	Homo sapiens	137-140
21956523-4	2012	PDX was developed as a synthetic folate analog antimetabolite that competitively inhibits dihydrofolate reductase (DHFR).	Folic Acid	33-39	dihydrofolate reductase	Homo sapiens	90-113
21956523-4	2012	PDX was developed as a synthetic folate analog antimetabolite that competitively inhibits dihydrofolate reductase (DHFR).	Folic Acid	33-39	dihydrofolate reductase	Homo sapiens	115-119
21986714-11	2012	Folic acid supplementation of the maternal diet was associated with reduced expression of PPARalpha, PPARgamma, and LXRalpha in the liver (P &lt; 0.001).	Folic Acid	0-10	peroxisome proliferator activated receptor alpha	Rattus norvegicus	90-99
21986714-17	2012	Furthermore, the expression of LXRalpha, PPARalpha, and PPARgamma in the liver and adipose tissue largely depends on the protein and folic acid content in the maternal diet during gestation.	Folic Acid	133-143	peroxisome proliferator activated receptor alpha	Rattus norvegicus	41-50
21938430-2	2012	Several transport mechanisms allow folate to enter the intracellular compartment with folate receptor-alpha being the major high-affinity receptor.	Folic Acid	35-41	folate receptor alpha	Homo sapiens	86-107
21938430-3	2012	Rare genetic variations in exons of the FR-alpha gene, FOLR1, were recently shown to cause severe folate deficiency accompanied by neurological and other disturbances.	Folic Acid	98-104	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	40-48
21938430-3	2012	Rare genetic variations in exons of the FR-alpha gene, FOLR1, were recently shown to cause severe folate deficiency accompanied by neurological and other disturbances.	Folic Acid	98-104	folate receptor alpha	Homo sapiens	55-60
21938430-5	2012	The aim of our study was to determine biochemically the haplotype structure of two linked polymorphisms in the FOLR1 gene, 1816delC and 1841G&gt;A, the prevalences of the mutated alleles across Eurasia, and their possible effects on physiological folate levels in vivo.	Folic Acid	247-253	folate receptor alpha	Homo sapiens	111-116
21938430-8	2012	Erythrocyte folate levels were studied in the Spanish population sample, where subjects carrying the double-mutated FOLR1 haplotype had significantly reduced levels by 27% (P = 0.039), adjusted for serum vitamin B(12) levels and MTHFR 677C&gt;T genotype, while the mean serum folate levels were only 20% lower among the carriers (P = 0.11).	Folic Acid	12-18	folate receptor alpha	Homo sapiens	116-121
21938430-8	2012	Erythrocyte folate levels were studied in the Spanish population sample, where subjects carrying the double-mutated FOLR1 haplotype had significantly reduced levels by 27% (P = 0.039), adjusted for serum vitamin B(12) levels and MTHFR 677C&gt;T genotype, while the mean serum folate levels were only 20% lower among the carriers (P = 0.11).	Folic Acid	276-282	folate receptor alpha	Homo sapiens	116-121
21938430-10	2012	Thus, we have demonstrated by molecular haplotyping an ancient double-mutated haplotype 1816delC-1841A in the FOLR1 gene, spread over the whole Eurasian continent, which may be of functional importance for uptake of folate in red blood cells.	Folic Acid	216-222	folate receptor alpha	Homo sapiens	110-115
21687976-4	2012	In this study, we analyzed the influence of the polymorphism C1420T in Serine hydroxymethyltransferase (SHMT) gene on maternal risk for DS and on metabolites concentrations of the folate pathway (serum folate and plasma homocysteine and methylmalonic acid).	Folic Acid	180-186	serine hydroxymethyltransferase 1	Homo sapiens	71-102
21687976-4	2012	In this study, we analyzed the influence of the polymorphism C1420T in Serine hydroxymethyltransferase (SHMT) gene on maternal risk for DS and on metabolites concentrations of the folate pathway (serum folate and plasma homocysteine and methylmalonic acid).	Folic Acid	180-186	serine hydroxymethyltransferase 1	Homo sapiens	104-108
21687976-4	2012	In this study, we analyzed the influence of the polymorphism C1420T in Serine hydroxymethyltransferase (SHMT) gene on maternal risk for DS and on metabolites concentrations of the folate pathway (serum folate and plasma homocysteine and methylmalonic acid).	Folic Acid	202-208	serine hydroxymethyltransferase 1	Homo sapiens	71-102
21687976-4	2012	In this study, we analyzed the influence of the polymorphism C1420T in Serine hydroxymethyltransferase (SHMT) gene on maternal risk for DS and on metabolites concentrations of the folate pathway (serum folate and plasma homocysteine and methylmalonic acid).	Folic Acid	202-208	serine hydroxymethyltransferase 1	Homo sapiens	104-108
22211358-7	2012	FR-beta(high) macrophages from OA synovial tissues represented the majority of folic acid-binding cells.	Folic Acid	79-89	folate receptor beta	Homo sapiens	0-7
23244153-1	2012	AIM: The present case-control study was conducted to explore the association of MTHFR gene polymorphism and relations of P16, MGMT and HMLH1 to MTHFR and folate intake.	Folic Acid	154-160	mutL homolog 1	Homo sapiens	135-140
21848426-1	2012	Two important polymorphisms of folate cycle enzymes, methylenetetrahydrofolate reductase (MTHFR) C677T and thymidylate synthase (TS) enhancer region (TSER) 28-bp tandem repeat, are related to risk of various types of cancer, including brain tumors, although there are few studies on this subject.	Folic Acid	31-37	thymidylate synthetase	Homo sapiens	107-127
21848426-1	2012	Two important polymorphisms of folate cycle enzymes, methylenetetrahydrofolate reductase (MTHFR) C677T and thymidylate synthase (TS) enhancer region (TSER) 28-bp tandem repeat, are related to risk of various types of cancer, including brain tumors, although there are few studies on this subject.	Folic Acid	31-37	thymidylate synthetase	Homo sapiens	129-131
21930702-2	2011	Because homocysteine, which accumulates intracellularly during folate deficiency, stimulated interactions between heterogeneous nuclear ribonucleoprotein E1 (hnRNP-E1) and an 18-base FR-alpha mRNA cis-element that led to increased FR biosynthesis and net up-regulation of FR at cell surfaces, hnRNP-E1 was a plausible candidate sensor of folate deficiency.	Folic Acid	63-69	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	183-191
21930702-2	2011	Because homocysteine, which accumulates intracellularly during folate deficiency, stimulated interactions between heterogeneous nuclear ribonucleoprotein E1 (hnRNP-E1) and an 18-base FR-alpha mRNA cis-element that led to increased FR biosynthesis and net up-regulation of FR at cell surfaces, hnRNP-E1 was a plausible candidate sensor of folate deficiency.	Folic Acid	338-344	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	183-191
21726415-7	2011	Loop residues 58-66 in CgDHFR and human DHFR are 1 and 3 A closer to the folate binding site, respectively, than loop residues in CaDHFR, suggesting that a properly size ligand could be a potent and selective dual inhibitor of CaDHFR and CgDHFR.	Folic Acid	73-79	dihydrofolate reductase	Homo sapiens	25-29
22777156-3	2012	METHODS: CD1 mice were treated with folic acid and kidneys subsequently examined using histochemistry, in addition to defining T cell profiles and evaluating renal function.	Folic Acid	36-46	CD1 antigen complex	Mus musculus	9-12
21787841-2	2011	BACKGROUND: The folate binding protein (FBP) regulates homeostasis and intracellular trafficking of folic acid, a vitamin of decisive importance in cell division and growth.	Folic Acid	100-110	folate receptor alpha	Homo sapiens	16-38
21787841-2	2011	BACKGROUND: The folate binding protein (FBP) regulates homeostasis and intracellular trafficking of folic acid, a vitamin of decisive importance in cell division and growth.	Folic Acid	100-110	folate receptor alpha	Homo sapiens	40-43
21787841-3	2011	We analyzed whether interrelationship between ligand binding and self-association of FBP plays a significant role in the physiology of folate binding.	Folic Acid	135-141	folate receptor alpha	Homo sapiens	85-88
21787841-10	2011	GENERAL SIGNIFICANCE: Self-association into multimers may protect binding sites, and in case of holo-FBP even folate from biological degradation.	Folic Acid	110-116	folate receptor alpha	Homo sapiens	101-104
21787841-11	2011	High-affinity folate binding in body secretions, typically containing 1-10nM FBP, requires the presence of natural detergents, i.e. cholesterol and phospholipids, to avoid complexation between apo- and holo-FBP.	Folic Acid	14-20	folate receptor alpha	Homo sapiens	77-80
21787841-11	2011	High-affinity folate binding in body secretions, typically containing 1-10nM FBP, requires the presence of natural detergents, i.e. cholesterol and phospholipids, to avoid complexation between apo- and holo-FBP.	Folic Acid	14-20	folate receptor alpha	Homo sapiens	207-210
21752681-4	2011	While the FRalpha defect is a disorder of brain-specific folate transport accompanied with cerebral folate deficiency (CFD) causing progressive neurological symptoms, LAMM syndrome is a solely malformative condition, with normal physical growth and cognitive development.	Folic Acid	57-63	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	10-17
21813587-8	2011	RESULTS: In terms of global disease activity, anti-C1q had the highest association with the PGA (p = 0.09) and was strongly associated with modified SELENA-SLEDAI (p = 0.009).	Folic Acid	92-95	complement C1q A chain	Homo sapiens	51-54
21876184-1	2011	Human dihydrofolate reductase (DHFR) was previously thought to be the only enzyme capable of the reduction of dihydrofolate to tetrahydrofolate; an essential reaction necessary to ensure a continuous supply of biologically active folate.	Folic Acid	13-19	dihydrofolate reductase	Homo sapiens	31-35
21748308-7	2011	Levels of maternal folate intake modified associations with SNPs in CBS, MTRR, and TYMS.	Folic Acid	19-25	thymidylate synthetase	Homo sapiens	83-87
21769326-0	2011	TAS2R38 bitter taste genetics, dietary vitamin C, and both natural and synthetic dietary folic acid predict folate status, a key micronutrient in the pathoaetiology of adenomatous polyps.	Folic Acid	108-114	taste 2 receptor member 38	Homo sapiens	0-7
21769326-2	2011	This study examined bitter taste genetics and whether variation in the TAS2R38 gene at three polymorphic loci (A49P, V262A and I296V) could alter dietary and systemic folate levels and dietary vitamin C intake, and whether a nutrigenetic circuit existed that might link bitter taste, folate/antioxidant status and risk for a colonic adenomatous polyp.	Folic Acid	167-173	taste 2 receptor member 38	Homo sapiens	71-78
21769326-2	2011	This study examined bitter taste genetics and whether variation in the TAS2R38 gene at three polymorphic loci (A49P, V262A and I296V) could alter dietary and systemic folate levels and dietary vitamin C intake, and whether a nutrigenetic circuit existed that might link bitter taste, folate/antioxidant status and risk for a colonic adenomatous polyp.	Folic Acid	284-290	taste 2 receptor member 38	Homo sapiens	71-78
25801697-4	2015	Consistent with the finding, folate transport by human PCFT stably expressed in Madin-Darby canine kidney II cells was reduced in a similar manner with simultaneous reductions in Vmax and Km by myricetin pretreatment.	Folic Acid	29-35	solute carrier family 46 member 1	Homo sapiens	55-59
25801697-5	2015	Attention may need to be given for a possibility that such a sustained inhibition of PCFT could potentially be a cause of the malabsorption of folate and also antifolate drugs.	Folic Acid	143-149	solute carrier family 46 member 1	Homo sapiens	85-89
24166930-1	2015	Thymidylate synthase (TYMS) is involved in the folate metabolism and provision of nucleotides needed for DNA synthesis and repair.	Folic Acid	47-53	thymidylate synthetase	Homo sapiens	0-20
21568878-1	2011	A set of hydroxamate derivatives of folic acid and methotrexate (MTX) was synthesized and evaluated for the inhibitory activity against histone deacetylase (HDAC) and dihydrofolate reductase (DHFR), two enzymes overexpressed in metastasizing tumors.	Folic Acid	36-46	dihydrofolate reductase	Homo sapiens	167-190
21568878-1	2011	A set of hydroxamate derivatives of folic acid and methotrexate (MTX) was synthesized and evaluated for the inhibitory activity against histone deacetylase (HDAC) and dihydrofolate reductase (DHFR), two enzymes overexpressed in metastasizing tumors.	Folic Acid	36-46	dihydrofolate reductase	Homo sapiens	192-196
22303332-10	2011	Tissue MTHFS protein levels are decreased in both Mthfs(gt/+) and Mthfs(+/+) mice placed on a folate and choline deficient diet, and mouse embryonic fibroblasts from Mthfs(gt/+) embryos exhibit decreased capacity for de novo purine synthesis without impairment in de novo thymidylate synthesis.	Folic Acid	94-100	5, 10-methenyltetrahydrofolate synthetase	Mus musculus	7-12
24166930-1	2015	Thymidylate synthase (TYMS) is involved in the folate metabolism and provision of nucleotides needed for DNA synthesis and repair.	Folic Acid	47-53	thymidylate synthetase	Homo sapiens	22-26
25975556-11	2015	Both levels of serum folate levels and FHIT protein expression were positively correlated (r = 0.213, P = 0.001), with an additive interaction seen between them in CIN I, CIN II/III, SCC groups.	Folic Acid	21-27	serpin family B member 3	Homo sapiens	183-186
25668494-7	2015	The results of the docking studies show that 2 could bind and inhibit both thymidylate synthase (TS) and the two folate-dependent purine biosynthetic enzymes (GARFTase and AICARFTase), which is consistent with the results of in vitro metabolic assays.	Folic Acid	113-119	thymidylate synthetase	Homo sapiens	75-95
21245875-0	2011	Relationship of folate, vitamin B12 and methylation of insulin-like growth factor-II in maternal and cord blood.	Folic Acid	16-22	insulin like growth factor 2	Homo sapiens	55-84
21245875-2	2011	The aim of the study is to investigate the relationship between folate, vitamin B(12) and methylation of the IGF2 gene in maternal and cord blood.	Folic Acid	64-70	insulin like growth factor 2	Homo sapiens	109-113
21556224-0	2011	Effect of paternal folate deficiency on placental folate content and folate receptor alpha expression in rats.	Folic Acid	19-25	folate receptor alpha	Rattus norvegicus	69-90
25816016-9	2015	Loss of FOLR1 resulted in growth inhibition, whereas FOLR1 overexpression promoted folate uptake and growth advantage in low folate conditions.	Folic Acid	83-89	folate receptor alpha	Homo sapiens	53-58
25816016-9	2015	Loss of FOLR1 resulted in growth inhibition, whereas FOLR1 overexpression promoted folate uptake and growth advantage in low folate conditions.	Folic Acid	125-131	folate receptor alpha	Homo sapiens	53-58
25677305-2	2015	Serine hydroxymethyltransferase (SHMT), the enzyme providing one-carbon units by converting serine and tetrahydrofolate (H4 PteGlu) to glycine and 5,10-CH2 -H4 PteGlu, therefore represents a target of interest in developing new chemotherapeutic drugs.	Folic Acid	124-130	serine hydroxymethyltransferase 1	Homo sapiens	0-31
21176954-3	2011	Imaging by SPECT/CT shows that nanoparticle conjugated with folic acids ensures a high intratumoral accumulation due to the folate-binding protein (FBP)-binding effect.	Folic Acid	60-71	folate receptor alpha	Homo sapiens	124-146
21176954-3	2011	Imaging by SPECT/CT shows that nanoparticle conjugated with folic acids ensures a high intratumoral accumulation due to the folate-binding protein (FBP)-binding effect.	Folic Acid	60-71	folate receptor alpha	Homo sapiens	148-151
25677305-2	2015	Serine hydroxymethyltransferase (SHMT), the enzyme providing one-carbon units by converting serine and tetrahydrofolate (H4 PteGlu) to glycine and 5,10-CH2 -H4 PteGlu, therefore represents a target of interest in developing new chemotherapeutic drugs.	Folic Acid	124-130	serine hydroxymethyltransferase 1	Homo sapiens	33-37
25677305-2	2015	Serine hydroxymethyltransferase (SHMT), the enzyme providing one-carbon units by converting serine and tetrahydrofolate (H4 PteGlu) to glycine and 5,10-CH2 -H4 PteGlu, therefore represents a target of interest in developing new chemotherapeutic drugs.	Folic Acid	160-166	serine hydroxymethyltransferase 1	Homo sapiens	0-31
25677305-2	2015	Serine hydroxymethyltransferase (SHMT), the enzyme providing one-carbon units by converting serine and tetrahydrofolate (H4 PteGlu) to glycine and 5,10-CH2 -H4 PteGlu, therefore represents a target of interest in developing new chemotherapeutic drugs.	Folic Acid	160-166	serine hydroxymethyltransferase 1	Homo sapiens	33-37
21093159-5	2011	A normal FPGS gene plays an essential role in intracellular folate homeostasis and metabolism, while a variant FPGS gene would lead to folate disturbances or even folate deficiency.	Folic Acid	60-66	folylpolyglutamate synthase	Homo sapiens	9-13
25504564-7	2015	The model we built using a scaling factor of 5.3 for the maximal uptake rate (Vmax) of OAT3, which estimated using plasma concentration profiles from patients given a 10-minute infusion of 500 mg/m(2) of pemetrexed supplemented with folic acid and vitamin B12, recovered the clinical data adequately.	Folic Acid	233-243	solute carrier family 22 member 8	Homo sapiens	87-91
21093159-5	2011	A normal FPGS gene plays an essential role in intracellular folate homeostasis and metabolism, while a variant FPGS gene would lead to folate disturbances or even folate deficiency.	Folic Acid	60-66	folylpolyglutamate synthase	Homo sapiens	111-115
21093159-5	2011	A normal FPGS gene plays an essential role in intracellular folate homeostasis and metabolism, while a variant FPGS gene would lead to folate disturbances or even folate deficiency.	Folic Acid	135-141	folylpolyglutamate synthase	Homo sapiens	111-115
21093159-5	2011	A normal FPGS gene plays an essential role in intracellular folate homeostasis and metabolism, while a variant FPGS gene would lead to folate disturbances or even folate deficiency.	Folic Acid	135-141	folylpolyglutamate synthase	Homo sapiens	111-115
21093159-6	2011	Since folate deficiency has been documented to contribute to cleft lip, the resulting folate deficiency induced by a variant FPGS gene would contribute to cleft lip, further strengthening that FPGS gene is a good candidate causative gene for cleft lip.	Folic Acid	6-12	folylpolyglutamate synthase	Homo sapiens	193-197
21093159-6	2011	Since folate deficiency has been documented to contribute to cleft lip, the resulting folate deficiency induced by a variant FPGS gene would contribute to cleft lip, further strengthening that FPGS gene is a good candidate causative gene for cleft lip.	Folic Acid	86-92	folylpolyglutamate synthase	Homo sapiens	125-129
21093159-6	2011	Since folate deficiency has been documented to contribute to cleft lip, the resulting folate deficiency induced by a variant FPGS gene would contribute to cleft lip, further strengthening that FPGS gene is a good candidate causative gene for cleft lip.	Folic Acid	86-92	folylpolyglutamate synthase	Homo sapiens	193-197
25441416-2	2015	MTX concentrations in a patient"s serum undergoing chemotherapy treatments can be determined by surface plasmon resonance (SPR) sensing using folic acid-functionalized gold nanoparticles (FA-AuNP) in competition with MTX for the bioreceptor, human dihydrofolate reductase (hDHFR) immobilized on the SPR sensor chip.	Folic Acid	142-152	dihydrofolate reductase	Homo sapiens	273-278
25514347-9	2015	Folate competition assays showed that PME-(PEG3.4k-FA2)1.72 complexes had stronger targeting ability than PME-(PEG3.5k)1.69 and PME-(PEG3.4k-FA1)1.66 complexes due to their higher folate density per PEG molecule.	Folic Acid	0-6	FA complementation group B	Homo sapiens	51-54
25514347-9	2015	Folate competition assays showed that PME-(PEG3.4k-FA2)1.72 complexes had stronger targeting ability than PME-(PEG3.5k)1.69 and PME-(PEG3.4k-FA1)1.66 complexes due to their higher folate density per PEG molecule.	Folic Acid	180-186	FA complementation group B	Homo sapiens	51-54
25514347-11	2015	Distribution and uptake in 3D multicellular spheroid assays showed that divalent folate could offer PME-(PEG3.4k-FA2)1.72 complexes stronger penetrating ability and higher cellular uptake.	Folic Acid	81-87	FA complementation group B	Homo sapiens	113-116
25559736-7	2015	One of the salient observations of this study was a coupled increase in the expression of renal, relA, NF-kB2, and p53 genes and proteins during folic acid induced AKI (FA AKI).	Folic Acid	145-155	transformation related protein 53, pseudogene	Mus musculus	115-118
26610311-7	2015	The objective of this study was to select the optimal producing yeast strain by determining the differences in nucleotide sequences in the FOL2, FOL3 and DFR1 genes of folic acid biosynthesis pathway.	Folic Acid	168-178	dihydrofolate reductase	Saccharomyces cerevisiae S288C	154-158
26413911-1	2015	BACKGROUND: Folate receptor alpha (FRA) is involved in folate accumulation and utilization, and is expressed in varying proportions in breast, ovary and parotid epithelial cells, among others.	Folic Acid	55-61	folate receptor alpha	Homo sapiens	12-33
26265252-0	2015	Molecular Modeling Investigation of Folic Acid Conjugation to MDM2 Inhibitors for Enhanced Cellular Uptake and Target Binding.	Folic Acid	36-46	transformed mouse 3T3 cell double minute 2	Mus musculus	62-66
26402008-2	2015	Our hypothesis was that cytokeratin 14 (CK14) expression could be used with blood-based biomarkers such as homocysteine, vitamin B12, and folate to identify individuals with MCI or AD from the Australian Imaging, Biomarkers and Lifestyle (AIBL) flagship study of aging.	Folic Acid	138-144	keratin 14	Homo sapiens	24-38
26402008-2	2015	Our hypothesis was that cytokeratin 14 (CK14) expression could be used with blood-based biomarkers such as homocysteine, vitamin B12, and folate to identify individuals with MCI or AD from the Australian Imaging, Biomarkers and Lifestyle (AIBL) flagship study of aging.	Folic Acid	138-144	keratin 14	Homo sapiens	40-44
25323390-0	2015	Intermediate states in the binding process of folic acid to folate receptor alpha: insights by molecular dynamics and metadynamics.	Folic Acid	46-56	folate receptor alpha	Homo sapiens	60-81
25203609-3	2015	When fluorescent-labeled folic acid was intravenously injected into mice bearing FR-positive human nasopharyngeal tumor KB, and FR-negative human prostate tumor PC-3 and mouse colon adenocarcinoma Colon 26, fluorescence was strongly detected in KB and Colon 26 tumors, and moderately in PC-3 tumor, indicating that folic acid was taken up by TAMs via FRbeta in PC-3 and Colon 26 tumors.	Folic Acid	25-35	chromobox 8	Homo sapiens	161-165
25203609-3	2015	When fluorescent-labeled folic acid was intravenously injected into mice bearing FR-positive human nasopharyngeal tumor KB, and FR-negative human prostate tumor PC-3 and mouse colon adenocarcinoma Colon 26, fluorescence was strongly detected in KB and Colon 26 tumors, and moderately in PC-3 tumor, indicating that folic acid was taken up by TAMs via FRbeta in PC-3 and Colon 26 tumors.	Folic Acid	25-35	chromobox 8	Homo sapiens	287-291
25203609-3	2015	When fluorescent-labeled folic acid was intravenously injected into mice bearing FR-positive human nasopharyngeal tumor KB, and FR-negative human prostate tumor PC-3 and mouse colon adenocarcinoma Colon 26, fluorescence was strongly detected in KB and Colon 26 tumors, and moderately in PC-3 tumor, indicating that folic acid was taken up by TAMs via FRbeta in PC-3 and Colon 26 tumors.	Folic Acid	25-35	chromobox 8	Homo sapiens	287-291
26006721-6	2015	Although difficult, early detection and diagnosis of cerebral folate deficiency are important because folinic acid at a pharmacologic dose may normalize outcome in PCFT gene defects, as well as bypass autoantibody-blocked folate receptors and enter the cerebrospinal fluid by way of the reduced folate carrier.	Folic Acid	62-68	solute carrier family 46 member 1	Homo sapiens	164-168
21310276-1	2011	Dihydrofolate reductase (DHFR) is a critical enzyme in folate metabolism and an important target of antineoplastic, antimicrobial, and antiinflammatory drugs.	Folic Acid	7-13	dihydrofolate reductase	Homo sapiens	25-29
21310277-11	2011	DHFR is necessary for maintaining sufficient CSF and RBC folate levels, even in the presence of adequate nutritional folate supply and normal plasma folate.	Folic Acid	57-63	dihydrofolate reductase	Homo sapiens	0-4
20632110-8	2011	To improve clinical course and metabolic abnormalities, treatment of Cbl-C defect usually consists of a combined approach that utilizes vitamin B12 to increase intracellular cobalamin and to maximize deficient enzyme activities, betaine to provide a substrate for the conversion of homocysteine into methionine through betaine-homocysteine methyltransferase, and folic acid to enhance remethylation pathway.	Folic Acid	363-373	Cbl proto-oncogene C	Homo sapiens	69-74
21178087-1	2011	The enzymes serine hydroxymethyltransferase 1 (gene name SHMT1) and methylenetetrahydrofolate reductase (gene name MTHFR) regulate key reactions in folate-mediated one-carbon metabolism.	Folic Acid	87-93	serine hydroxymethyltransferase 1	Homo sapiens	57-62
21437875-2	2011	Activated macrophages abundantly express folate receptor beta (FRbeta), which can be targeted using radioactive-labeled folic acid.	Folic Acid	120-130	folate receptor beta	Rattus norvegicus	41-61
26202812-1	2015	BACKGROUND/AIMS: The objective of this study was to examine the responses of p53 promoter methylation involved in kidney structure and function of early weaning intrauterine growth retarded (IUGR) rats to dietary folic acid supplementation.	Folic Acid	213-223	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	77-80
26202812-7	2015	However, the changes in p53 gene expression and DNA methylation status of IUGR rats were reversed by dietary folic acid supplementation.	Folic Acid	109-119	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	24-27
26202812-8	2015	CONCLUSIONS: Our study showed for the first time that folic acid supplementation during early period of life could reverse the abnormality in renal p53 methylation status and protein expression, glomerular volume and renal function of IUGR rats offspring.	Folic Acid	54-64	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	148-151
26521878-2	2015	For instance, folic acid (FA) as a tumor-targeting ligand is widely used because of overexpression of folate receptor-alpha (FR-alpha) in various kinds of epithelial tumor cells.	Folic Acid	14-24	folate receptor 1 (adult)	Mus musculus	102-123
25339667-11	2014	Although folate targeting of liposomes enhanced the sensitization of folate receptor-alpha(+) ovarian tumor cells in vitro, this did not confer further therapeutic advantage in vivo.	Folic Acid	9-15	folate receptor alpha	Homo sapiens	69-90
25341694-4	2014	The role of folic acid in carcinogenesis may be modulated by polymorphism C677T in MTHFR and tandem repeats 2R/3R in the promoter site of TYMS gene that are related to decreased enzymatic activity and quantity and availability of the enzyme, respectively.	Folic Acid	12-22	thymidylate synthetase	Homo sapiens	138-142
25456743-10	2014	FRalpha antibody titers in patients fluctuated over time varying between negative and high titers, modulating folate flux to the CNS, which explained low CSF folate values in 6 and normal values in 7 patients.	Folic Acid	110-116	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	0-7
25456743-10	2014	FRalpha antibody titers in patients fluctuated over time varying between negative and high titers, modulating folate flux to the CNS, which explained low CSF folate values in 6 and normal values in 7 patients.	Folic Acid	158-164	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	0-7
25456743-16	2014	Clinical negative or positive symptoms are speculated to be influenced by the level and evolution of FRalpha antibody titers which determine folate flux to the brain with up- or down-regulation of brain folate intermediates linked to metabolic processes affecting homocysteine levels, synthesis of tetrahydrobiopterin and neurotransmitters.	Folic Acid	141-147	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	101-108
25456743-16	2014	Clinical negative or positive symptoms are speculated to be influenced by the level and evolution of FRalpha antibody titers which determine folate flux to the brain with up- or down-regulation of brain folate intermediates linked to metabolic processes affecting homocysteine levels, synthesis of tetrahydrobiopterin and neurotransmitters.	Folic Acid	203-209	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	101-108
25240194-0	2014	Disturbed biopterin and folate metabolism in the Qdpr-deficient mouse.	Folic Acid	24-30	quinoid dihydropteridine reductase	Mus musculus	49-53
25240194-5	2014	Furthermore, we revealed wide alterations in folate-associated metabolism in the Qdpr(-/-) mice, which suggests an interconnection between folate and biopterin metabolism in the transgenic mouse model.	Folic Acid	45-51	quinoid dihydropteridine reductase	Mus musculus	81-85
25240194-5	2014	Furthermore, we revealed wide alterations in folate-associated metabolism in the Qdpr(-/-) mice, which suggests an interconnection between folate and biopterin metabolism in the transgenic mouse model.	Folic Acid	139-145	quinoid dihydropteridine reductase	Mus musculus	81-85
25164808-9	2014	We concluded that mitochondrial FPGS is required because folate polyglutamates are not substrates for transport across the mitochondrial membrane in either direction and that polyglutamation not only traps folates in the cytosol, but also in the mitochondrial matrix.	Folic Acid	206-213	folylpolyglutamate synthase	Homo sapiens	32-36
25339854-2	2014	In this research, emtansine (DM1)-loaded star-shaped folate-core polylactide-d-alpha-tocopheryl polyethylene glycol 1000 succinate (FA-PLA-TPGS-DM1) copolymer which demonstrated superior anticancer activity in vitro/vivo in comparison with linear FA-PLA-TPGS nanoparticles was applied to be a vector of DM1 for FR(+) breast cancer therapy.	Folic Acid	53-59	immunoglobulin heavy diversity 1-7	Homo sapiens	29-32
21561849-1	2011	BACKGROUND: Current methods for measuring folates in clinical laboratories are competitive folate binding protein assays.	Folic Acid	42-49	folate receptor alpha	Homo sapiens	91-113
20177420-4	2011	5-FU targets folate metabolism through inhibition of thymidylate synthase (TYMS).	Folic Acid	13-19	thymidylate synthetase	Homo sapiens	53-73
25066213-4	2014	Thirteen variants in the pyrimidine metabolism genes, DPYD, DPYS, PPAT, and TYMS, also interacted significantly with folate in a multivariant analysis (corrected p = 9.9 x 10-6) but collectively explained only 0.2% of OC risk.	Folic Acid	117-123	thymidylate synthetase	Homo sapiens	76-80
25066213-5	2014	Although no other associations were significant after multiple testing correction, variants in SHMT1 in 1-C transfer, previously reported with OC, suggested lower risk at higher folate (p(interaction) = 0.03-0.006).	Folic Acid	178-184	serine hydroxymethyltransferase 1	Homo sapiens	95-100
25066213-7	2014	SHMT1 SNP-by-folate interactions are plausible but require further validation.	Folic Acid	13-19	serine hydroxymethyltransferase 1	Homo sapiens	0-5
21636975-0	2011	Methylation variation at IGF2 differentially methylated regions and maternal folic acid use before and during pregnancy.	Folic Acid	77-87	insulin like growth factor 2	Homo sapiens	25-29
25298785-6	2014	The breakpoint was close to the folate sensitive rare fragile site FRA11B and the aphidicolin inducible common fragile site FRA11G, the co-localization fragile site could have caused instability and constitutional chromosomal breakage.	Folic Acid	32-38	Cbl proto-oncogene	Homo sapiens	67-73
21238436-1	2011	10-Formyltetrahydrofolate dehydrogenase (FDH, ALDH1L1), an abundant cytosolic enzyme of folate metabolism, shares significant sequence similarity with enzymes of the aldehyde dehydrogenase (ALDH) family.	Folic Acid	19-25	Aldehyde dehydrogenase	Escherichia coli	166-188
21238436-1	2011	10-Formyltetrahydrofolate dehydrogenase (FDH, ALDH1L1), an abundant cytosolic enzyme of folate metabolism, shares significant sequence similarity with enzymes of the aldehyde dehydrogenase (ALDH) family.	Folic Acid	19-25	Aldehyde dehydrogenase	Escherichia coli	46-50
20177420-4	2011	5-FU targets folate metabolism through inhibition of thymidylate synthase (TYMS).	Folic Acid	13-19	thymidylate synthetase	Homo sapiens	75-79
21179031-1	2011	BACKGROUND: Pralatrexate is a dihydrofolate reductase (DHFR) inhibitor with high affinity for reduced folate carrier 1 (RFC-1) and folylpolyglutamate synthetase (FPGS), resulting in extensive internalization and accumulation in tumour cells.	Folic Acid	37-43	dihydrofolate reductase	Homo sapiens	55-59
25298785-6	2014	The breakpoint was close to the folate sensitive rare fragile site FRA11B and the aphidicolin inducible common fragile site FRA11G, the co-localization fragile site could have caused instability and constitutional chromosomal breakage.	Folic Acid	32-38	fragile site, aphidicolin type, common, fra(11)(q23.3)	Homo sapiens	124-130
25023142-1	2014	The folate receptor alpha (FOLR1) present in milk has widely been studied to investigate the effects of pasteurization, ultra-high temperature (UHT) processing and fermentation on net folate concentration.	Folic Acid	4-10	folate receptor alpha	Bos taurus	27-32
21126022-1	2011	Folate analogue inhibitors of Leishmania major pteridine reductase (PTR1) are potential antiparasitic drug candidates for combined therapy with dihydrofolate reductase (DHFR) inhibitors.	Folic Acid	0-6	dihydrofolate reductase	Homo sapiens	169-173
22303319-12	2011	Low maternal folate reduced p53 methylation in adults (p = 0.04).	Folic Acid	13-19	transformation related protein 53, pseudogene	Mus musculus	28-31
25023142-2	2014	However, the folate binding mechanism with FOLR1, and effect of temperature on FOLR1-folate complex is poorly explored till now in bovine milk which is a chief resource of folate.	Folic Acid	13-19	folate receptor alpha	Bos taurus	43-48
21346251-1	2011	The human proton coupled folate transporter (PCFT) is involved in low pH-dependent intestinal folate transport.	Folic Acid	25-31	solute carrier family 46 member 1	Homo sapiens	45-49
20870783-1	2011	Arylamine N-acetyltransferase-1 (NAT1) has been associated with disorders involving folate metabolism, such as spina bifida, as well as numerous human cancers.	Folic Acid	84-90	N-acetyltransferase 1	Homo sapiens	0-31
25023142-2	2014	However, the folate binding mechanism with FOLR1, and effect of temperature on FOLR1-folate complex is poorly explored till now in bovine milk which is a chief resource of folate.	Folic Acid	85-91	folate receptor alpha	Bos taurus	79-84
20870783-1	2011	Arylamine N-acetyltransferase-1 (NAT1) has been associated with disorders involving folate metabolism, such as spina bifida, as well as numerous human cancers.	Folic Acid	84-90	N-acetyltransferase 1	Homo sapiens	33-37
25023142-2	2014	However, the folate binding mechanism with FOLR1, and effect of temperature on FOLR1-folate complex is poorly explored till now in bovine milk which is a chief resource of folate.	Folic Acid	85-91	folate receptor alpha	Bos taurus	79-84
25023142-4	2014	To understand the folate deficiency in milk after processing, in absence of experimental structure, 3D model of bovine FOLR1 (bvFOLR1) was built followed by 40ns molecular dynamics (MD) simulation.	Folic Acid	18-24	folate receptor alpha	Bos taurus	119-124
24447348-2	2014	We examined whether single nucleotide polymorphisms (SNPs) in enzymes of the folic acid pathway (folylpoly-gamma-glutamate synthetase [FPGS], gamma-glutamyl hydrolase [GGH], and methylenetetrahydrofolate reductase [MTHFR]) associate with significant adverse events (SigAE).	Folic Acid	77-87	folylpolyglutamate synthase	Homo sapiens	97-133
22023442-3	2011	Within the parasite, folates are reduced by a bifunctional DHFR (dihydrofolate reductase)-TS (thymidylate synthase) and by a novel PTR1 (pteridine reductase 1), which reduces both folates and unconjugated pteridines.	Folic Acid	21-28	dihydrofolate reductase	Homo sapiens	59-63
22023442-3	2011	Within the parasite, folates are reduced by a bifunctional DHFR (dihydrofolate reductase)-TS (thymidylate synthase) and by a novel PTR1 (pteridine reductase 1), which reduces both folates and unconjugated pteridines.	Folic Acid	21-28	dihydrofolate reductase	Homo sapiens	65-88
24447348-2	2014	We examined whether single nucleotide polymorphisms (SNPs) in enzymes of the folic acid pathway (folylpoly-gamma-glutamate synthetase [FPGS], gamma-glutamyl hydrolase [GGH], and methylenetetrahydrofolate reductase [MTHFR]) associate with significant adverse events (SigAE).	Folic Acid	77-87	folylpolyglutamate synthase	Homo sapiens	135-139
22023442-3	2011	Within the parasite, folates are reduced by a bifunctional DHFR (dihydrofolate reductase)-TS (thymidylate synthase) and by a novel PTR1 (pteridine reductase 1), which reduces both folates and unconjugated pteridines.	Folic Acid	21-28	thymidylate synthetase	Homo sapiens	94-114
22023442-3	2011	Within the parasite, folates are reduced by a bifunctional DHFR (dihydrofolate reductase)-TS (thymidylate synthase) and by a novel PTR1 (pteridine reductase 1), which reduces both folates and unconjugated pteridines.	Folic Acid	180-187	dihydrofolate reductase	Homo sapiens	65-88
24447348-2	2014	We examined whether single nucleotide polymorphisms (SNPs) in enzymes of the folic acid pathway (folylpoly-gamma-glutamate synthetase [FPGS], gamma-glutamyl hydrolase [GGH], and methylenetetrahydrofolate reductase [MTHFR]) associate with significant adverse events (SigAE).	Folic Acid	77-87	gamma-glutamyl hydrolase	Homo sapiens	168-171
22023442-3	2011	Within the parasite, folates are reduced by a bifunctional DHFR (dihydrofolate reductase)-TS (thymidylate synthase) and by a novel PTR1 (pteridine reductase 1), which reduces both folates and unconjugated pteridines.	Folic Acid	180-187	thymidylate synthetase	Homo sapiens	94-114
24708746-10	2014	The Clic4 null mice show increased susceptibility to folic acid-induced acute kidney injury but no difference in recovery from acute injury, no nuclear redistribution of CLIC4 following injury, and no significant difference in activation of the TGFbeta-signaling pathway as reflected in the level of phosphorylation of SMADs 2 and 3.	Folic Acid	53-63	chloride intracellular channel 4 (mitochondrial)	Mus musculus	4-9
24500500-9	2014	Low folate levels were associated with hMLH1 hypermethylation.	Folic Acid	4-10	mutL homolog 1	Homo sapiens	39-44
21159649-1	2010	The chemotherapeutic drug pemetrexed, an inhibitor of thymidylate synthase, has an important secondary target in human leukemic cells, aminoimidazolecarboxamide ribonucleotide formyltransferase (AICART), the second folate-dependent enzyme of purine biosynthesis.	Folic Acid	215-221	thymidylate synthetase	Homo sapiens	54-74
24629913-0	2014	Folic acid stimulation of neural stem cell proliferation is associated with altered methylation profile of PI3K/Akt/CREB.	Folic Acid	0-10	cAMP responsive element binding protein 1	Rattus norvegicus	116-120
20805364-1	2010	The proton-coupled folate transporter (PCFT; SLC46A1) mediates folate transport into enterocytes in the proximal small intestine; pcft loss-of-function mutations are the basis for hereditary folate malabsorption.	Folic Acid	19-25	solute carrier family 46 member 1	Homo sapiens	39-43
20805364-1	2010	The proton-coupled folate transporter (PCFT; SLC46A1) mediates folate transport into enterocytes in the proximal small intestine; pcft loss-of-function mutations are the basis for hereditary folate malabsorption.	Folic Acid	19-25	solute carrier family 46 member 1	Homo sapiens	45-52
20805364-1	2010	The proton-coupled folate transporter (PCFT; SLC46A1) mediates folate transport into enterocytes in the proximal small intestine; pcft loss-of-function mutations are the basis for hereditary folate malabsorption.	Folic Acid	19-25	solute carrier family 46 member 1	Homo sapiens	130-134
24729732-11	2014	Vintafolide is a folate-desacetylvinblastine monohydrazide conjugate, allowing a liberation of the drug into the cytoplasm of cancerous cells via the FR-alpha (FRalpha) and endocytosis, with high specificity.	Folic Acid	17-23	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	150-158
21629435-4	2010	Due to the pivotal role that DHFR plays in folate metabolism and cancer treatment, changes in the level of DHFR expression can affect susceptibility to a variety of diseases dependent on folate status such as spina bifida and cancer.	Folic Acid	43-49	dihydrofolate reductase	Homo sapiens	29-33
21629435-4	2010	Due to the pivotal role that DHFR plays in folate metabolism and cancer treatment, changes in the level of DHFR expression can affect susceptibility to a variety of diseases dependent on folate status such as spina bifida and cancer.	Folic Acid	43-49	dihydrofolate reductase	Homo sapiens	107-111
21629435-4	2010	Due to the pivotal role that DHFR plays in folate metabolism and cancer treatment, changes in the level of DHFR expression can affect susceptibility to a variety of diseases dependent on folate status such as spina bifida and cancer.	Folic Acid	187-193	dihydrofolate reductase	Homo sapiens	29-33
21629435-4	2010	Due to the pivotal role that DHFR plays in folate metabolism and cancer treatment, changes in the level of DHFR expression can affect susceptibility to a variety of diseases dependent on folate status such as spina bifida and cancer.	Folic Acid	187-193	dihydrofolate reductase	Homo sapiens	107-111
21629435-5	2010	Likewise, variability in DHFR expression can affect sensitivity to anti-cancer drugs such as the folate antagonist methotrexate.	Folic Acid	97-103	dihydrofolate reductase	Homo sapiens	25-29
24729732-11	2014	Vintafolide is a folate-desacetylvinblastine monohydrazide conjugate, allowing a liberation of the drug into the cytoplasm of cancerous cells via the FR-alpha (FRalpha) and endocytosis, with high specificity.	Folic Acid	17-23	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	160-167
21215183-12	2010	After being given folic acid to MTX treated group and dhfr knocking-down group, the expressions of tbx5 and nppa were increased.	Folic Acid	18-28	T-box transcription factor 5a	Danio rerio	99-103
24333266-7	2014	Plasma folate and thymidylate synthase (TYMS) 5"-UTR 28 bp tandem repeat showed an inverse association with methylation of RFC1 and MHC2TA.	Folic Acid	7-13	class II major histocompatibility complex transactivator	Homo sapiens	132-138
21301589-2	2010	Antifolates are inhibitors of key enzymes in folate metabolism, namely dihydrofolate reductase, beta-glycinamide ribonucleotide transformylase, 5"-amino-4"-imidazolecarboxamide ribonucleotide transformylase, and thymidylate synthetase.	Folic Acid	4-10	thymidylate synthetase	Homo sapiens	212-234
24136919-5	2014	In contrast, induction of nephrotoxic stress (acute and chronic folic acid-induced nephropathy) in Sirt1(endo-/-) mice resulted in robust acute renal functional deterioration followed by an exaggerated fibrotic response compared with control animals.	Folic Acid	64-74	sirtuin 1	Mus musculus	99-104
20852008-0	2010	Associations of folate, vitamin B12, homocysteine, and folate-pathway polymorphisms with prostate-specific antigen velocity in men with localized prostate cancer.	Folic Acid	55-61	kallikrein related peptidase 3	Homo sapiens	89-114
27025730-3	2014	The folate metabolic pathway leads to synthesis of required precursors for cellular function and contains a critical node, dihydrofolate reductase (DHFR), which is shared between prokaryotes and eukaryotes.	Folic Acid	4-10	dihydrofolate reductase	Homo sapiens	123-146
20852008-2	2010	We investigated whether these and other elements of folate metabolism were associated with prostate-specific antigen (PSA) velocity (PSAV) as a proxy measure of prostate cancer progression in men with localized prostate cancer.	Folic Acid	52-58	kallikrein related peptidase 3	Homo sapiens	91-116
27025730-3	2014	The folate metabolic pathway leads to synthesis of required precursors for cellular function and contains a critical node, dihydrofolate reductase (DHFR), which is shared between prokaryotes and eukaryotes.	Folic Acid	4-10	dihydrofolate reductase	Homo sapiens	148-152
20724482-2	2010	The proton-coupled folate transporter (PCFT/SLC46A1) mediates obligatory intestinal folate absorption.	Folic Acid	19-25	solute carrier family 46 member 1	Homo sapiens	39-43
24205029-3	2013	Mice null for the murine NAT1 homolog (Nat2) show several phenotypes consistent with altered folate homeostasis.	Folic Acid	93-99	N-acetyl transferase 1	Mus musculus	25-29
20724482-2	2010	The proton-coupled folate transporter (PCFT/SLC46A1) mediates obligatory intestinal folate absorption.	Folic Acid	19-25	solute carrier family 46 member 1	Homo sapiens	44-51
20724482-3	2010	Loss-of-function mutations in PCFT result in hereditary folate malabsorption, an autosomal recessive disorder characterized by very low folate levels in the blood and cerebrospinal fluid.	Folic Acid	56-62	solute carrier family 46 member 1	Homo sapiens	30-34
21044425-3	2010	Two related derivatives of folic acid, aminopterin and amethopterin (MTX,) were found to give rapid symptomatic relief in cases of psoriasis vulgaris and psoriatic arthritis.	Folic Acid	27-37	metaxin 1	Homo sapiens	69-72
20838574-0	2010	Folic Acid supplementation stimulates notch signaling and cell proliferation in embryonic neural stem cells.	Folic Acid	0-10	notch receptor 1	Rattus norvegicus	38-43
20838574-1	2010	The present study investigated the effect of folic acid supplementation on the Notch signaling pathway and cell proliferation in rat embryonic neural stem cells (NSCs).	Folic Acid	45-55	notch receptor 1	Rattus norvegicus	79-84
20838574-7	2010	Supplementation of NSCs with folic acid increased the mRNA and protein expression levels of Notch1 and Hes5.	Folic Acid	29-39	notch receptor 1	Rattus norvegicus	92-98
20838574-9	2010	Embryonic NSCs respond to folic acid supplementation with increased Notch signaling and cell proliferation.	Folic Acid	26-36	notch receptor 1	Rattus norvegicus	68-73
19879746-10	2010	Moreover, folic acid caused a reduction in PTEN (phosphatase and tensin homolog deleted on chromosome 10) expression, an increase in the phosphorylation of endothelial nitric oxide synthase (eNOS(Ser1177)) and Akt(Ser473), and an enhanced interaction of heat shock protein 90 (HSP90) with eNOS in both strains, with greater magnitude observed in +db/+db mice.	Folic Acid	10-20	nitric oxide synthase 3, endothelial cell	Mus musculus	156-189
19879746-10	2010	Moreover, folic acid caused a reduction in PTEN (phosphatase and tensin homolog deleted on chromosome 10) expression, an increase in the phosphorylation of endothelial nitric oxide synthase (eNOS(Ser1177)) and Akt(Ser473), and an enhanced interaction of heat shock protein 90 (HSP90) with eNOS in both strains, with greater magnitude observed in +db/+db mice.	Folic Acid	10-20	nitric oxide synthase 3, endothelial cell	Mus musculus	191-195
19879746-10	2010	Moreover, folic acid caused a reduction in PTEN (phosphatase and tensin homolog deleted on chromosome 10) expression, an increase in the phosphorylation of endothelial nitric oxide synthase (eNOS(Ser1177)) and Akt(Ser473), and an enhanced interaction of heat shock protein 90 (HSP90) with eNOS in both strains, with greater magnitude observed in +db/+db mice.	Folic Acid	10-20	nitric oxide synthase 3, endothelial cell	Mus musculus	289-293
20619709-5	2010	At physiological MTHF concentrations the high-affinity FOLR1 represents the predominant mechanism for cellular incorporation, while at high MTHF concentrations other transport mechanisms participate in folate uptake.	Folic Acid	202-208	folate receptor alpha	Homo sapiens	55-60
21472308-2	2010	The enzymes 5,10-methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS) are essential participants in folic acid metabolism and DNA synthesis.	Folic Acid	121-131	thymidylate synthetase	Homo sapiens	65-85
21472308-2	2010	The enzymes 5,10-methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS) are essential participants in folic acid metabolism and DNA synthesis.	Folic Acid	121-131	thymidylate synthetase	Homo sapiens	87-89
20534379-7	2010	Thus, Alx3 emerges as a candidate gene for human neural tube defects and reveals the existence of induced transcription factor gene expression as a previously unknown mechanism by which folic acid prevents neural tube closure defects.	Folic Acid	186-196	ALX homeobox 3	Homo sapiens	6-10
20020129-2	2010	Pemetrexed is polyglutamated by the folylpolyglutamate synthase (FPGS) and blocks folate metabolism and DNA synthesis by inhibiting TS, dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT).	Folic Acid	82-88	folylpolyglutamate synthase	Homo sapiens	65-69
20424322-3	2010	In animals with combined spinal cord and sciatic nerve injury, folate-mediated CNS axon regeneration was found to depend on injury-related induction of the high-affinity folate receptor 1 (Folr1).	Folic Acid	63-69	folate receptor alpha	Homo sapiens	170-187
20424322-3	2010	In animals with combined spinal cord and sciatic nerve injury, folate-mediated CNS axon regeneration was found to depend on injury-related induction of the high-affinity folate receptor 1 (Folr1).	Folic Acid	63-69	folate receptor alpha	Homo sapiens	189-194
20424322-4	2010	The activity of folate was dependent on its activation by the enzyme dihydrofolate reductase (Dhfr) and a functional methylation cycle.	Folic Acid	16-22	dihydrofolate reductase	Homo sapiens	69-92
20424322-4	2010	The activity of folate was dependent on its activation by the enzyme dihydrofolate reductase (Dhfr) and a functional methylation cycle.	Folic Acid	16-22	dihydrofolate reductase	Homo sapiens	94-98
20424322-5	2010	The effect of folate on the regeneration of afferent spinal neurons was biphasic and dose dependent and correlated closely over its dose range with global and gene-specific DNA methylation and with expression of both the folate receptor Folr1 and the de novo DNA methyltransferases.	Folic Acid	14-20	folate receptor alpha	Homo sapiens	237-242
19636555-10	2010	CONCLUSIONS: The expression level of FPGS, GGH and ABCC1 in CRC tissues could predict the reduced folate level after LV administration, and these factors may determine the efficacy of LV treatment.	Folic Acid	98-104	folylpolyglutamate synthase	Homo sapiens	37-41
19636555-10	2010	CONCLUSIONS: The expression level of FPGS, GGH and ABCC1 in CRC tissues could predict the reduced folate level after LV administration, and these factors may determine the efficacy of LV treatment.	Folic Acid	98-104	gamma-glutamyl hydrolase	Homo sapiens	43-46
20026257-2	2010	Both human NAT1 and its murine equivalent NAT2 have previously been shown to play roles in the catabolism of folate, which is required for the synthesis of S-adenosylmethionine, the methyl donor for cellular methylation reactions.	Folic Acid	109-115	N-acetyltransferase 1	Homo sapiens	11-15
20206792-2	2010	OBJECTIVE: The aim of this study was to determine whether folic acid supplementation increases the dosage requirement of the CYP2C9 substrate warfarin, and the formation clearance of the CYP2C9-mediated product, (S)-7-hydroxywarfarin.	Folic Acid	58-68	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	125-131
20571234-2	2010	The target enzyme for 5- Fluorouracil is thymidylate synthase (TYMS) this enzyme is also involved in folate metabolism.	Folic Acid	101-107	thymidylate synthetase	Homo sapiens	41-61
20571234-2	2010	The target enzyme for 5- Fluorouracil is thymidylate synthase (TYMS) this enzyme is also involved in folate metabolism.	Folic Acid	101-107	thymidylate synthetase	Homo sapiens	63-67
19839929-3	2010	Polyglutamate derivatives mainly inhibit three key enzymes of intracellular folate metabolism, i.e. thymidylates synthase (TYMS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), with TYMS being the most relevant target.	Folic Acid	76-82	thymidylate synthetase	Homo sapiens	100-121
19839929-3	2010	Polyglutamate derivatives mainly inhibit three key enzymes of intracellular folate metabolism, i.e. thymidylates synthase (TYMS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), with TYMS being the most relevant target.	Folic Acid	76-82	thymidylate synthetase	Homo sapiens	123-127
19839929-3	2010	Polyglutamate derivatives mainly inhibit three key enzymes of intracellular folate metabolism, i.e. thymidylates synthase (TYMS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), with TYMS being the most relevant target.	Folic Acid	76-82	dihydrofolate reductase	Homo sapiens	130-153
19839929-3	2010	Polyglutamate derivatives mainly inhibit three key enzymes of intracellular folate metabolism, i.e. thymidylates synthase (TYMS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), with TYMS being the most relevant target.	Folic Acid	76-82	dihydrofolate reductase	Homo sapiens	155-159
19839929-3	2010	Polyglutamate derivatives mainly inhibit three key enzymes of intracellular folate metabolism, i.e. thymidylates synthase (TYMS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), with TYMS being the most relevant target.	Folic Acid	76-82	thymidylate synthetase	Homo sapiens	225-229
19707223-2	2010	Cytoplasmic serine hydroxymethyltransferase (cSHMT) affects the flow of one-carbon units through the folate metabolic network, but there is little research on a role for genetic variation in cSHMT in determining breast cancer risk.	Folic Acid	101-107	serine hydroxymethyltransferase 1	Homo sapiens	0-43
19707223-2	2010	Cytoplasmic serine hydroxymethyltransferase (cSHMT) affects the flow of one-carbon units through the folate metabolic network, but there is little research on a role for genetic variation in cSHMT in determining breast cancer risk.	Folic Acid	101-107	serine hydroxymethyltransferase 1	Homo sapiens	45-50
20164552-1	2010	Folic acid deficiency and hyperhomocysteinemia potentiate amyloid-beta (Abeta) neuron toxicity.	Folic Acid	0-10	amyloid beta (A4) precursor protein	Mus musculus	72-77
20164552-3	2010	We propose that folic acid might have a synergistic effect for memantine in protecting neurons from Abeta accumulation.	Folic Acid	16-26	amyloid beta (A4) precursor protein	Mus musculus	100-105
21209714-2	2010	One of these forms, 5,10 methylenetetrahydrofolic acid (CH(2)THF), is the key one-carbon donor and reduced folate substrate for thymidylate synthase (TS).	Folic Acid	107-113	thymidylate synthetase	Homo sapiens	128-148
19951991-3	2009	We report that folate receptor beta (FRbeta), encoded by the FOLR2 gene, is a marker for macrophages generated in the presence of M-CSF (M2), but not GM-CSF (M1), and whose expression correlates with increased folate uptake ability.	Folic Acid	15-21	folate receptor beta	Homo sapiens	37-43
19951991-3	2009	We report that folate receptor beta (FRbeta), encoded by the FOLR2 gene, is a marker for macrophages generated in the presence of M-CSF (M2), but not GM-CSF (M1), and whose expression correlates with increased folate uptake ability.	Folic Acid	15-21	folate receptor beta	Homo sapiens	61-66
19951991-3	2009	We report that folate receptor beta (FRbeta), encoded by the FOLR2 gene, is a marker for macrophages generated in the presence of M-CSF (M2), but not GM-CSF (M1), and whose expression correlates with increased folate uptake ability.	Folic Acid	15-21	colony stimulating factor 1	Homo sapiens	130-135
19951991-4	2009	The acquisition of folate uptake ability by macrophages is promoted by M-CSF, maintained by IL-4, prevented by GM-CSF, and reduced by IFNgamma, indicating a link between FRbeta expression and M2 polarization.	Folic Acid	19-25	colony stimulating factor 1	Homo sapiens	71-76
19951991-4	2009	The acquisition of folate uptake ability by macrophages is promoted by M-CSF, maintained by IL-4, prevented by GM-CSF, and reduced by IFNgamma, indicating a link between FRbeta expression and M2 polarization.	Folic Acid	19-25	colony stimulating factor 2	Homo sapiens	111-117
19951991-4	2009	The acquisition of folate uptake ability by macrophages is promoted by M-CSF, maintained by IL-4, prevented by GM-CSF, and reduced by IFNgamma, indicating a link between FRbeta expression and M2 polarization.	Folic Acid	19-25	folate receptor beta	Homo sapiens	170-176
19951991-6	2009	FRbeta is expressed, and mediates folate uptake, by CD163(+) CD68(+) CD14(+) IL-10-producing TAM, and its expression is induced by tumor-derived ascitic fluid and conditioned medium from fibroblasts and tumor cell lines in an M-CSF-dependent manner.	Folic Acid	34-40	folate receptor beta	Homo sapiens	0-6
19951991-7	2009	These results establish FRbeta as a marker for M2 regulatory macrophage polarization and indicate that folate conjugates of therapeutic drugs are a potential immunotherapy tool to target TAM.	Folic Acid	103-109	folate receptor beta	Homo sapiens	24-30
19764999-9	2009	Folate concentrations and methylation of LINE-1, RASSF1, and RUNX3 were significantly higher in adenocarcinoma compared to squamous cell carcinoma (SCC).	Folic Acid	0-6	serpin family B member 3	Homo sapiens	148-151
19764999-10	2009	Two sets of array-based data retrieved from the Gene Expression Omnibus consistently showed that expression of FOLR1, a folate transport enzyme, and GGH, an enzyme that prevents folate retention, were higher and lower, respectively, in adenocarcinomas compared to SCC.	Folic Acid	120-126	folate receptor alpha	Homo sapiens	111-116
19764999-10	2009	Two sets of array-based data retrieved from the Gene Expression Omnibus consistently showed that expression of FOLR1, a folate transport enzyme, and GGH, an enzyme that prevents folate retention, were higher and lower, respectively, in adenocarcinomas compared to SCC.	Folic Acid	120-126	gamma-glutamyl hydrolase	Homo sapiens	149-152
19638421-0	2009	Folate rescues lithium-, homocysteine- and Wnt3A-induced vertebrate cardiac anomalies.	Folic Acid	0-6	wingless-type MMTV integration site family, member 3A	Mus musculus	15-48
19596833-5	2009	In both strains fed with folic acid (71 microg/kg), a reduction of beta(2)-AR protein expression was observed compared to the respective controls.	Folic Acid	25-35	adrenergic receptor, beta 2	Mus musculus	67-77
19596833-6	2009	In +db/+db mice, folic acid (5.7 and 71 microg/kg) consumption caused a dose-dependent increase of beta(3)-AR protein expression compared to controls.	Folic Acid	17-27	adrenergic receptor, beta 3	Mus musculus	99-109
19664055-6	2009	In addition to its role in xenobiotic metabolism, several studies have suggested that NAT1 is involved in other physiological and/or pathological processes, such as folate metabolism or cancer progression.	Folic Acid	165-171	N-acetyltransferase 1	Homo sapiens	86-90
19508863-0	2009	Hereditary folate malabsorption: a positively charged amino acid at position 113 of the proton-coupled folate transporter (PCFT/SLC46A1) is required for folic acid binding.	Folic Acid	153-163	solute carrier family 46 member 1	Homo sapiens	123-127
19508863-0	2009	Hereditary folate malabsorption: a positively charged amino acid at position 113 of the proton-coupled folate transporter (PCFT/SLC46A1) is required for folic acid binding.	Folic Acid	153-163	solute carrier family 46 member 1	Homo sapiens	128-135
19508863-1	2009	The proton-coupled folate transporter (PCFT/SLC46A1) mediates intestinal folate uptake at acidic pH.	Folic Acid	19-25	solute carrier family 46 member 1	Homo sapiens	39-43
19508863-1	2009	The proton-coupled folate transporter (PCFT/SLC46A1) mediates intestinal folate uptake at acidic pH.	Folic Acid	19-25	solute carrier family 46 member 1	Homo sapiens	44-51
19508863-2	2009	Some loss of folic acid (FA) transport mutations in PCFT from hereditary folate malabsorption (HFM) patients cluster in R113, thereby suggesting a functional role for this residue.	Folic Acid	13-23	solute carrier family 46 member 1	Homo sapiens	52-56
19536847-0	2009	DHFR 19-bp insertion/deletion polymorphism and MTHFR C677T in adult acute lymphoblastic leukaemia: is the risk reduction due to intracellular folate unbalancing?	Folic Acid	142-148	dihydrofolate reductase	Homo sapiens	0-4
19448666-5	2009	We demonstrate that endogenous c-myc increased (13)C labeling of ribose sugars, purines and amino acids, indicating partitioning of glucose carbons into C1/folate and pentose phosphate pathways, and increased tricarboxylic acid cycle turnover at the expense of anaplerotic flux.	Folic Acid	156-162	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	31-36
19152916-3	2009	We investigated the mechanisms underlying the modulation of MCP-1 expression by long-term "folate stress".	Folic Acid	91-97	C-C motif chemokine ligand 2	Homo sapiens	60-65
19389703-0	2009	The functional roles of the His247 and His281 residues in folate and proton translocation mediated by the human proton-coupled folate transporter SLC46A1.	Folic Acid	58-64	solute carrier family 46 member 1	Homo sapiens	146-153
19451595-5	2009	We also show that folate supplementation enhanced the DNA remethylation through the Sp1/Sp3-mediated transcriptional up-regulation of genes coding for Dnmt3a and Dnmt3b proteins, two de novo methyltranferases.	Folic Acid	18-24	DNA methyltransferase 3 alpha	Homo sapiens	151-157
19451595-5	2009	We also show that folate supplementation enhanced the DNA remethylation through the Sp1/Sp3-mediated transcriptional up-regulation of genes coding for Dnmt3a and Dnmt3b proteins, two de novo methyltranferases.	Folic Acid	18-24	DNA methyltransferase 3 beta	Homo sapiens	162-168
20641205-1	2004	The primary pathway for entry of folate into cells is with the facilitated transporter folate-binding protein (FBP), which has a low affinity for folate with a Km value of 1-5 muM.	Folic Acid	33-39	folate receptor alpha	Homo sapiens	87-109
20641205-1	2004	The primary pathway for entry of folate into cells is with the facilitated transporter folate-binding protein (FBP), which has a low affinity for folate with a Km value of 1-5 muM.	Folic Acid	33-39	folate receptor alpha	Homo sapiens	111-114
20641205-1	2004	The primary pathway for entry of folate into cells is with the facilitated transporter folate-binding protein (FBP), which has a low affinity for folate with a Km value of 1-5 muM.	Folic Acid	87-93	folate receptor alpha	Homo sapiens	111-114
19170661-4	2009	METHODS: In this study we estimated the flux of fatty acids (FA) through the stearoyl-CoA desaturase (SCD), phosphatidylethanolamine-N-methyltransferase (PEMT), and FA elongation pathways in relation to liver triacylglycerol (TG) content in Yucatan micropigs fed a 40% ethanol folate-deficient diet with or without supplementation with S-adenosyl methionine (SAM) compared with controls.	Folic Acid	277-283	stearoyl-CoA desaturase	Sus scrofa	77-100
19170661-4	2009	METHODS: In this study we estimated the flux of fatty acids (FA) through the stearoyl-CoA desaturase (SCD), phosphatidylethanolamine-N-methyltransferase (PEMT), and FA elongation pathways in relation to liver triacylglycerol (TG) content in Yucatan micropigs fed a 40% ethanol folate-deficient diet with or without supplementation with S-adenosyl methionine (SAM) compared with controls.	Folic Acid	277-283	stearoyl-CoA desaturase	Sus scrofa	102-105
19117321-10	2009	Mutations in folate-pathway genes do not cause NTDs, except for 30% exencephaly in folate-treated Folr1.	Folic Acid	13-19	folate receptor 1 (adult)	Mus musculus	98-103
18602821-4	2009	Bivariate analysis showed that folate deficiency (0.3 nmol/L of folate vs. 2.27 mumol/L in control medium) displayed rapid and coordinated regulation during the first 2 h with differential expression for hRfc1 (increased by 69%) and Ahcy (decreased by 437%).	Folic Acid	31-37	adenosylhomocysteinase	Homo sapiens	233-237
18602821-4	2009	Bivariate analysis showed that folate deficiency (0.3 nmol/L of folate vs. 2.27 mumol/L in control medium) displayed rapid and coordinated regulation during the first 2 h with differential expression for hRfc1 (increased by 69%) and Ahcy (decreased by 437%).	Folic Acid	64-70	adenosylhomocysteinase	Homo sapiens	233-237
19374805-2	2009	TS is the target enzyme of 5-fluorouracil (5-FU) and involved in folate metabolism.	Folic Acid	65-71	thymidylate synthetase	Homo sapiens	0-2
19091803-10	2009	Co-incubation with folic acid blocked ethanol-induced teratogenesis, with up-regulated Hoxa1 and down-regulated miR-10a (P &lt; 0.01).	Folic Acid	19-29	microRNA 10a	Mus musculus	112-119
19240161-0	2009	Cellular folate status modulates the expression of BCRP and MRP multidrug transporters in cancer cell lines from different origins.	Folic Acid	9-15	BCR pseudogene 1	Homo sapiens	51-55
19240161-9	2009	Under these circumstances, folate supplementation might improve the efficacy of chemotherapeutic drugs by decreasing BCRP expression.	Folic Acid	27-33	BCR pseudogene 1	Homo sapiens	117-121
19056550-3	2009	OBJECTIVE: The aim of the present study was to investigate the effect of 3 treatments (placebo, folic acid, and [6S]-5-methylTHF) on milk folate and folate-binding protein (FBP) concentrations and to determine whether unmetabolized folic acid is present in milk.	Folic Acid	96-106	folate receptor alpha	Homo sapiens	173-176
19056550-8	2009	CONCLUSION: Maternal intake of synthetic folic acid leads to the appearance of unmetabolized folic acid in milk and, seemingly, a down-regulation of milk FBP synthesis.	Folic Acid	41-51	folate receptor alpha	Homo sapiens	154-157
19116913-0	2009	Folate receptor beta as a potential delivery route for novel folate antagonists to macrophages in the synovial tissue of rheumatoid arthritis patients.	Folic Acid	61-67	folate receptor beta	Homo sapiens	0-20
19116913-4	2009	Binding affinities of FRbeta for folate antagonists were assessed by competition experiments for 3H-folic acid binding on FRbeta-transfected cells.	Folic Acid	33-39	folate receptor beta	Homo sapiens	22-28
19116913-5	2009	Efficacy of FRbeta-mediated internalization of folate antagonists was evaluated by assessment of antiproliferative effects against FRbeta-transfected cells.	Folic Acid	47-53	folate receptor beta	Homo sapiens	12-18
19116913-5	2009	Efficacy of FRbeta-mediated internalization of folate antagonists was evaluated by assessment of antiproliferative effects against FRbeta-transfected cells.	Folic Acid	47-53	folate receptor beta	Homo sapiens	131-137
19116913-8	2009	Screening of 10 new-generation folate antagonists revealed 4 compounds for which FRbeta had a high binding affinity (20-77-fold higher than for MTX).	Folic Acid	31-37	folate receptor beta	Homo sapiens	81-87
19238999-0	2008	[Effects of folic acid on neural cell apoptosis and Notch1 mRNA expression in rats with brain infarction].	Folic Acid	12-22	notch receptor 1	Rattus norvegicus	52-58
18842806-6	2008	DESIGN: Thirteen single nucleotide polymorphisms (SNPs) in genes involved in folate uptake and metabolism, including folate hydrolase (FOLH1), folate polyglutamate synthase (FPGS), gamma-glutamyl hydrolase (GGH), methylene tetrahydrofolate reductase (MTHFR), methionine synthase (MTR), proton-coupled folate transporter (PCFT), and reduced folate carrier (RFC1), were studied in a cohort of 991 individuals.	Folic Acid	77-83	folylpolyglutamate synthase	Homo sapiens	174-178
18842806-6	2008	DESIGN: Thirteen single nucleotide polymorphisms (SNPs) in genes involved in folate uptake and metabolism, including folate hydrolase (FOLH1), folate polyglutamate synthase (FPGS), gamma-glutamyl hydrolase (GGH), methylene tetrahydrofolate reductase (MTHFR), methionine synthase (MTR), proton-coupled folate transporter (PCFT), and reduced folate carrier (RFC1), were studied in a cohort of 991 individuals.	Folic Acid	77-83	gamma-glutamyl hydrolase	Homo sapiens	181-205
18937353-9	2008	CONCLUSIONS: The results of these analyses indicate that, if maternal CCL-2 genotype is related to the risk of spina bifida, this relationship is likely to be more complex than initially hypothesized, perhaps depending upon folate intake, MTHFR 677C&gt;T genotype, the distribution of folate derivatives, and immune/inflammatory activity.	Folic Acid	224-230	C-C motif chemokine ligand 2	Homo sapiens	70-75
18937353-9	2008	CONCLUSIONS: The results of these analyses indicate that, if maternal CCL-2 genotype is related to the risk of spina bifida, this relationship is likely to be more complex than initially hypothesized, perhaps depending upon folate intake, MTHFR 677C&gt;T genotype, the distribution of folate derivatives, and immune/inflammatory activity.	Folic Acid	285-291	C-C motif chemokine ligand 2	Homo sapiens	70-75
18804286-2	2008	This population-based cohort study has examined serum from pregnant mothers for autoantibodies to FRs, antibodies to bovine folate binding protein (FBP), and inhibition of folic acid binding to FR and FBP in association with NTD risk.	Folic Acid	172-182	folate receptor alpha	Bos taurus	201-204
18804286-5	2008	The presence of IgG and IgM antibodies to human FR, bovine FBP, and inhibition of folic acid binding to FR and FBP was determined.	Folic Acid	82-92	folate receptor alpha	Bos taurus	111-114
18650265-7	2008	Together, these studies demonstrate that the intestinal folate uptake process undergoes differentiation-dependent regulation and that this regulation is mediated via changes in the level of expression of both the RFC and PCFT.	Folic Acid	56-62	solute carrier family 46 member 1	Homo sapiens	221-225
18559978-5	2008	Moreover, WT PCFT transfectants displayed a 50% folic acid growth requirement concentration of 7 nM, whereas mock and R113C transfectants revealed 24- to 27-fold higher values.	Folic Acid	48-58	solute carrier family 46 member 1	Homo sapiens	13-17
18559978-8	2008	These findings establish a novel loss of function mutation in HFM residing in an intracellular loop of PCFT crucial for folate transport.	Folic Acid	120-126	solute carrier family 46 member 1	Homo sapiens	103-107
18776693-3	2008	Since folate binding to placental brush-border membrane vesicles (BBMVs) was strongly inhibited by phosphatidylinositol-specific phospholipase C (PI-PLC) treatment, it is possible that FRalpha, a glycosyl phosphatidylinositol linked glycoprotein, is a candidate for folate uptake from maternal blood to the placenta.	Folic Acid	6-12	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	185-192
18776693-3	2008	Since folate binding to placental brush-border membrane vesicles (BBMVs) was strongly inhibited by phosphatidylinositol-specific phospholipase C (PI-PLC) treatment, it is possible that FRalpha, a glycosyl phosphatidylinositol linked glycoprotein, is a candidate for folate uptake from maternal blood to the placenta.	Folic Acid	266-272	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	185-192
18776693-4	2008	Moreover, additional inhibitory effects of thiamine pyrophosphate (TPP) and hemin on folate uptake after PI-PLC treatment suggested that not only FRalpha but also RFC and heme carrier protein 1 (HCP1) are involved in the folate transport mechanism in the human placenta.	Folic Acid	85-91	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	146-153
18776693-4	2008	Moreover, additional inhibitory effects of thiamine pyrophosphate (TPP) and hemin on folate uptake after PI-PLC treatment suggested that not only FRalpha but also RFC and heme carrier protein 1 (HCP1) are involved in the folate transport mechanism in the human placenta.	Folic Acid	85-91	solute carrier family 46 member 1	Homo sapiens	171-193
18776693-4	2008	Moreover, additional inhibitory effects of thiamine pyrophosphate (TPP) and hemin on folate uptake after PI-PLC treatment suggested that not only FRalpha but also RFC and heme carrier protein 1 (HCP1) are involved in the folate transport mechanism in the human placenta.	Folic Acid	85-91	solute carrier family 46 member 1	Homo sapiens	195-199
18776693-4	2008	Moreover, additional inhibitory effects of thiamine pyrophosphate (TPP) and hemin on folate uptake after PI-PLC treatment suggested that not only FRalpha but also RFC and heme carrier protein 1 (HCP1) are involved in the folate transport mechanism in the human placenta.	Folic Acid	221-227	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	146-153
18776693-4	2008	Moreover, additional inhibitory effects of thiamine pyrophosphate (TPP) and hemin on folate uptake after PI-PLC treatment suggested that not only FRalpha but also RFC and heme carrier protein 1 (HCP1) are involved in the folate transport mechanism in the human placenta.	Folic Acid	221-227	solute carrier family 46 member 1	Homo sapiens	171-193
18776693-4	2008	Moreover, additional inhibitory effects of thiamine pyrophosphate (TPP) and hemin on folate uptake after PI-PLC treatment suggested that not only FRalpha but also RFC and heme carrier protein 1 (HCP1) are involved in the folate transport mechanism in the human placenta.	Folic Acid	221-227	solute carrier family 46 member 1	Homo sapiens	195-199
18776693-7	2008	These findings suggest that FRalpha, RFC, and HCP1 are important carriers of folate in the placenta during pregnancy.	Folic Acid	77-83	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	28-35
18776693-7	2008	These findings suggest that FRalpha, RFC, and HCP1 are important carriers of folate in the placenta during pregnancy.	Folic Acid	77-83	solute carrier family 46 member 1	Homo sapiens	46-50
18776693-8	2008	The results of this study suggest that increases in the expression levels of FRalpha, RFC, and HCP1 in the placenta play an important role in the response to increased need for folate for the placenta and fetus during development with the progress of gestation.	Folic Acid	177-183	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	77-84
18776693-8	2008	The results of this study suggest that increases in the expression levels of FRalpha, RFC, and HCP1 in the placenta play an important role in the response to increased need for folate for the placenta and fetus during development with the progress of gestation.	Folic Acid	177-183	solute carrier family 46 member 1	Homo sapiens	95-99
17896178-1	2008	Cytosolic serine hydroxymethyltransferase (cSHMT) is key to intersection of folate-metabolic pathway, participating in the pyrimidine synthesis for DNA repair.	Folic Acid	76-82	serine hydroxymethyltransferase 1	Homo sapiens	0-41
17896178-1	2008	Cytosolic serine hydroxymethyltransferase (cSHMT) is key to intersection of folate-metabolic pathway, participating in the pyrimidine synthesis for DNA repair.	Folic Acid	76-82	serine hydroxymethyltransferase 1	Homo sapiens	43-48
18339680-7	2008	Among women, the relative risks of tumors with BRAF mutations or MLH1 hypermethylation were also increased in the highest tertiles of folate and vitamin B6 intake, respectively, but these did not reach statistical significance.	Folic Acid	134-140	mutL homolog 1	Homo sapiens	65-69
18672898-1	2008	Folylpoly-gamma-glutamate synthetase (FPGS, EC 6.3.2.17) is an ATP-dependent ligase that catalyzes formation of poly-gamma-glutamate derivatives of reduced folates and antifolates such as methotrexate and 5,10-dideaza-5,6,7,8-tetrahydrofolate (DDAH 4PteGlu 1).	Folic Acid	156-163	folylpolyglutamate synthase	Homo sapiens	0-36
18672898-1	2008	Folylpoly-gamma-glutamate synthetase (FPGS, EC 6.3.2.17) is an ATP-dependent ligase that catalyzes formation of poly-gamma-glutamate derivatives of reduced folates and antifolates such as methotrexate and 5,10-dideaza-5,6,7,8-tetrahydrofolate (DDAH 4PteGlu 1).	Folic Acid	156-163	folylpolyglutamate synthase	Homo sapiens	38-42
18721750-4	2008	In addition to this rare nitrile hydratase, the cluster encodes a GTP cyclohydrolase I, linking the biosynthesis of deazapurines to folate biosynthesis, and a set of purine salvage/biosynthesis genes, which presumably convert the guanine moiety from GTP to the adenine-like deazapurine base found in toyocamycin and sangivamycin.	Folic Acid	132-138	DF17_RS03565	Streptomyces rimosus	66-86
18186951-2	2008	We investigated the effect of feeding pregnant rats a protein-restricted (PR) diet with different amounts of folic acid on the methylation of individual CpG dinucleotides in the hepatic PPAR alpha promoter in juvenile offspring, and the effect of the maternal PR diet on CpG methylation in adult offspring.	Folic Acid	109-119	peroxisome proliferator activated receptor alpha	Rattus norvegicus	186-196
18498130-0	2008	Multiple B-vitamin inadequacy amplifies alterations induced by folate depletion in p53 expression and its downstream effector MDM2.	Folic Acid	63-69	transformation related protein 53, pseudogene	Mus musculus	83-86
18498130-3	2008	Our study therefore investigated whether combined dietary restriction of these vitamins amplifies aberrations in the epigenetic and genetic integrity of the p53 gene that is induced by folate depletion alone.	Folic Acid	185-191	transformation related protein 53, pseudogene	Mus musculus	157-160
18498130-6	2008	Within the hypermutable region of p53 (exons 5-8), DNA strand breaks were induced within exons 6 and 8 by folate combined with B2, B6 and B12 restriction (p &lt; 0.05); such effects were not significantly induced by mild folate depletion alone.	Folic Acid	106-112	transformation related protein 53, pseudogene	Mus musculus	34-37
18498130-6	2008	Within the hypermutable region of p53 (exons 5-8), DNA strand breaks were induced within exons 6 and 8 by folate combined with B2, B6 and B12 restriction (p &lt; 0.05); such effects were not significantly induced by mild folate depletion alone.	Folic Acid	221-227	transformation related protein 53, pseudogene	Mus musculus	34-37
18498130-8	2008	Furthermore, the expression of p53 and MDM2 were significantly decreased (p &lt; or = 0.05) by the combined depletion state but not by folate depletion alone.	Folic Acid	135-141	transformation related protein 53, pseudogene	Mus musculus	31-34
18498130-8	2008	Furthermore, the expression of p53 and MDM2 were significantly decreased (p &lt; or = 0.05) by the combined depletion state but not by folate depletion alone.	Folic Acid	135-141	transformed mouse 3T3 cell double minute 2	Mus musculus	39-43
18498130-9	2008	These data indicate that inadequacies of other 1-carbon vitamins may amplify aberrations of the p53 gene induced by folate depletion alone, implying that concurrent inadequacies in several of these vitamins may have added tumorigenic potential beyond that observed with isolated folate depletion.	Folic Acid	116-122	transformation related protein 53, pseudogene	Mus musculus	96-99
18498130-9	2008	These data indicate that inadequacies of other 1-carbon vitamins may amplify aberrations of the p53 gene induced by folate depletion alone, implying that concurrent inadequacies in several of these vitamins may have added tumorigenic potential beyond that observed with isolated folate depletion.	Folic Acid	279-285	transformation related protein 53, pseudogene	Mus musculus	96-99
18597513-3	2008	Folate differentially altered activity and expression of proteins involved in proliferation [e.g., PCNA], DNA repair [e.g., XRCC5, MSH2], apoptosis [e.g., BAG family chaperone protein, DIABLO and porin], cytoskeletal organization [e.g., actin, ezrin, elfin], and expression of proteins implicated in malignant transformation [COMT, Nit2].	Folic Acid	0-6	proliferating cell nuclear antigen	Homo sapiens	99-103
18597513-3	2008	Folate differentially altered activity and expression of proteins involved in proliferation [e.g., PCNA], DNA repair [e.g., XRCC5, MSH2], apoptosis [e.g., BAG family chaperone protein, DIABLO and porin], cytoskeletal organization [e.g., actin, ezrin, elfin], and expression of proteins implicated in malignant transformation [COMT, Nit2].	Folic Acid	0-6	diablo IAP-binding mitochondrial protein	Homo sapiens	185-191
18597513-3	2008	Folate differentially altered activity and expression of proteins involved in proliferation [e.g., PCNA], DNA repair [e.g., XRCC5, MSH2], apoptosis [e.g., BAG family chaperone protein, DIABLO and porin], cytoskeletal organization [e.g., actin, ezrin, elfin], and expression of proteins implicated in malignant transformation [COMT, Nit2].	Folic Acid	0-6	nitrilase family member 2	Homo sapiens	332-336
18614692-5	2008	Feeding animals a folate-deficient diet (FD) for 3 months induced degeneration of CA3 pyramidal neurons in Ung-/- but not Ung+/+ mice along with decreased hippocampal expression of brain-derived neurotrophic factor protein and decreased brain levels of antioxidant glutathione.	Folic Acid	18-24	brain derived neurotrophic factor	Mus musculus	181-214
18439912-4	2008	CONCLUSION: PML test resulted useful in detecting higher number of hyperhomocysteinemic AD patients who may have the chance of an early folate treatment.	Folic Acid	136-142	PML nuclear body scaffold	Homo sapiens	12-15
18413293-2	2008	Methionine synthase reductase (MTRR) is required for activation of methionine synthase, a folate- and vitamin B(12)-dependent enzyme.	Folic Acid	90-96	5-methyltetrahydrofolate-homocysteine methyltransferase	Mus musculus	67-86
18418463-1	2008	Low gene expression of folylpolyglutamate synthase (FPGS) in colorectal mucosa correlates with low folate levels and poor survival of colorectal cancer (CRC) patients.	Folic Acid	99-105	folylpolyglutamate synthase	Homo sapiens	23-50
18418463-1	2008	Low gene expression of folylpolyglutamate synthase (FPGS) in colorectal mucosa correlates with low folate levels and poor survival of colorectal cancer (CRC) patients.	Folic Acid	99-105	folylpolyglutamate synthase	Homo sapiens	52-56
18406523-4	2008	RT-PCR experiments suggest that the higher folate binding could be due to an enhanced expression in AD fibroblasts of folate receptor alpha.	Folic Acid	43-49	folate receptor alpha	Homo sapiens	118-139
17597160-8	2008	In patients with PAD or DM, folic acid and B vitamins administration resulted in significant reduction (P &lt; 0.001) of plasma levels of homocysteine (20.9% and 26.2%), VEGF (29.7% and 40.4%) and endostatin (9.4% and 5.7%), respectively.	Folic Acid	28-38	collagen type XVIII alpha 1 chain	Homo sapiens	197-207
17597160-9	2008	Moreover, VEGF and endostatin mRNA expression in leukocytes was down-regulated in all patients after B vitamins and folate treatment.	Folic Acid	116-122	collagen type XVIII alpha 1 chain	Homo sapiens	19-29
17597160-10	2008	CONCLUSION: These findings demonstrate that lowering of homocysteine with B vitamins and folic acid resulted in substantial reduction of plasma levels of VEGF but minimal reduction of endostatin and in down-regulation of their expression in leukocytes in patients with PAD or DM.	Folic Acid	89-99	collagen type XVIII alpha 1 chain	Homo sapiens	184-194
18414409-9	2008	Trends for inverse association between GGH expression and the concentration of folate intermediates were also observed.	Folic Acid	79-85	gamma-glutamyl hydrolase	Homo sapiens	39-42
18414409-12	2008	CIMP+ CRC is associated with low expression of GGH, suggesting involvement of the folate pathway in the development and/or progression of this phenotype.	Folic Acid	82-88	gamma-glutamyl hydrolase	Homo sapiens	47-50
18329281-7	2008	Stimulation with folic acid alone or in combination with preeclamptic serum up-regulated ISG12A and 6-16.	Folic Acid	17-27	interferon alpha inducible protein 27	Homo sapiens	89-104
18329281-10	2008	Folic acid may ameliorate endothelial cell stability in preeclampsia by up-regulating ISG12A.	Folic Acid	0-10	interferon alpha inducible protein 27	Homo sapiens	86-92
17868491-0	2008	Gender-specific modulation of tumorigenesis by folic acid supply in the Apc mouse during early neonatal life.	Folic Acid	47-57	APC, WNT signaling pathway regulator	Mus musculus	72-75
17868491-11	2008	These data suggest that folate depletion post-weaning was protective against neoplasia in female Apc+/Min mice and highlights the need for further investigation of the optimal timing and dose of folic acid supplementation with regard to colorectal cancer risk.	Folic Acid	24-30	APC, WNT signaling pathway regulator	Mus musculus	97-100
18268116-8	2008	However, DNMT3b -149TT was associated with an increase in adenoma risk among individuals with low folate and methionine intake (OR, 2.00; 95% CI, 1.06-3.78, P interaction = 0.10).	Folic Acid	98-104	DNA methyltransferase 3 beta	Homo sapiens	9-15
17531458-2	2008	Our group has previously shown that both reduced folate carrier (RFC1) and folate receptor alpha (FRalpha) seem to be involved in the uptake of [3H]folic acid ([3H]FA) by a human trophoblast cell line (BeWo) and by human primary cultured cytotrophoblasts.	Folic Acid	148-158	folate receptor alpha	Homo sapiens	75-96
17531458-2	2008	Our group has previously shown that both reduced folate carrier (RFC1) and folate receptor alpha (FRalpha) seem to be involved in the uptake of [3H]folic acid ([3H]FA) by a human trophoblast cell line (BeWo) and by human primary cultured cytotrophoblasts.	Folic Acid	148-158	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	98-105
17660957-0	2008	Impaired clearance of methotrexate in organic anion transporter 3 (Slc22a8) knockout mice: a gender specific impact of reduced folates.	Folic Acid	127-134	solute carrier family 22 (organic anion transporter), member 8	Mus musculus	67-74
18003745-1	2008	The human proton-coupled folate transporter (hPCFT) is a recently discovered intestinal transporter involved in folate uptake in epithelia (and possibly other cells).	Folic Acid	25-31	solute carrier family 46 member 1	Homo sapiens	45-50
18406541-2	2008	Genetic polymorphisms in folate pathway related enzymes including methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, methionine synthase (MTR) A2756G, thymidylate synthase (TS) 28-bp tandem repeat, and reduced folate carrier (RFC) G80A have been shown to be associated with increased susceptibility for several cancers.	Folic Acid	25-31	thymidylate synthetase	Homo sapiens	162-182
17681554-5	2008	Using either specific substrates as probes of different CYP isoforms or the regio- and stereo-selective metabolism of testosterone as a multibiomarker, we found that folic acid markedly inactivated most of the Phase-I XME analysed; up to 54% for the CYP1A1-linked deethylation of ethoxyresorufin in males, and up to 86% for the testosterone 2alpha-hydroxylase (CYP2C11) in females, after 2 months treatment.	Folic Acid	166-176	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	250-256
17681554-5	2008	Using either specific substrates as probes of different CYP isoforms or the regio- and stereo-selective metabolism of testosterone as a multibiomarker, we found that folic acid markedly inactivated most of the Phase-I XME analysed; up to 54% for the CYP1A1-linked deethylation of ethoxyresorufin in males, and up to 86% for the testosterone 2alpha-hydroxylase (CYP2C11) in females, after 2 months treatment.	Folic Acid	166-176	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	361-368
18804700-1	2008	In mammals, folate is used as a carrier of one-carbon units (C(1)) in nucleic acids metabolism and biological methylation.	Folic Acid	12-18	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	61-65
18008023-5	2007	At the molecular level, reduced folate transport activity in renal tissue during chronic ethanol ingestion was attributable to decreased expression of reduced folate carrier (RFC) and folate binding protein (FBP).	Folic Acid	32-38	glycine N-methyltransferase	Rattus norvegicus	184-206
18008023-5	2007	At the molecular level, reduced folate transport activity in renal tissue during chronic ethanol ingestion was attributable to decreased expression of reduced folate carrier (RFC) and folate binding protein (FBP).	Folic Acid	32-38	glycine N-methyltransferase	Rattus norvegicus	208-211
18029487-9	2007	DNA strand breaks within the Apc mutation cluster region were induced by folate depletion combined with inadequacies of riboflavin, vitamin B-6, and vitamin B-12 (P &lt; 0.05), but such effects were not induced by folate depletion alone.	Folic Acid	73-79	APC, WNT signaling pathway regulator	Mus musculus	29-32
18029487-9	2007	DNA strand breaks within the Apc mutation cluster region were induced by folate depletion combined with inadequacies of riboflavin, vitamin B-6, and vitamin B-12 (P &lt; 0.05), but such effects were not induced by folate depletion alone.	Folic Acid	214-220	APC, WNT signaling pathway regulator	Mus musculus	29-32
18029487-10	2007	Similarly, minor changes in the expression of Apc, beta-catenin, and cyclin D1 produced by mild folate depletion were significantly magnified by multiple vitamin depletion.	Folic Acid	96-102	APC, WNT signaling pathway regulator	Mus musculus	46-49
17898134-0	2007	Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, and response to dietary folate restriction.	Folic Acid	18-24	solute carrier family 46 member 1	Homo sapiens	39-46
17898134-1	2007	This laboratory recently identified a human gene that encodes a novel folate transporter [Homo sapiens proton-coupled folate transporter (HsPCFT); SLC46A1] required for intestinal folate absorption.	Folic Acid	70-76	solute carrier family 46 member 1	Homo sapiens	147-154
18025275-6	2007	FPGS modulation-induced changes in polyglutamylation of both antifolates and folate cofactors and in intracellular folate pools affected chemosensitivity of breast cancer cells to pemetrexed and trimetrexate whose cytotoxic effects do or do not depend on polyglutamylation, respectively, in a predictable manner.	Folic Acid	65-71	folylpolyglutamate synthase	Homo sapiens	0-4
18025275-6	2007	FPGS modulation-induced changes in polyglutamylation of both antifolates and folate cofactors and in intracellular folate pools affected chemosensitivity of breast cancer cells to pemetrexed and trimetrexate whose cytotoxic effects do or do not depend on polyglutamylation, respectively, in a predictable manner.	Folic Acid	77-83	folylpolyglutamate synthase	Homo sapiens	0-4
18025275-7	2007	However, the effects of FPGS modulation on the chemosensitivity of breast cancer cells to 5FU and methotrexate seem to be highly complex and depend not only on polyglutamylation of a specific target intracellular folate cofactor or methotrexate, respectively, but also on total intracellular folate pools and polyglutamylation of other intracellular folate cofactors.	Folic Acid	213-219	folylpolyglutamate synthase	Homo sapiens	24-28
18025275-7	2007	However, the effects of FPGS modulation on the chemosensitivity of breast cancer cells to 5FU and methotrexate seem to be highly complex and depend not only on polyglutamylation of a specific target intracellular folate cofactor or methotrexate, respectively, but also on total intracellular folate pools and polyglutamylation of other intracellular folate cofactors.	Folic Acid	292-298	folylpolyglutamate synthase	Homo sapiens	24-28
18025275-7	2007	However, the effects of FPGS modulation on the chemosensitivity of breast cancer cells to 5FU and methotrexate seem to be highly complex and depend not only on polyglutamylation of a specific target intracellular folate cofactor or methotrexate, respectively, but also on total intracellular folate pools and polyglutamylation of other intracellular folate cofactors.	Folic Acid	292-298	folylpolyglutamate synthase	Homo sapiens	24-28
17702748-1	2007	Cytoplasmic serine hydroxymethyltransferase (cSHMT) enzyme levels are elevated by the expression of the heavy chain ferritin (H ferritin) cDNA in cultured cells without corresponding changes in mRNA levels, resulting in enhanced folate-dependent de novo thymidylate biosynthesis and impaired homocysteine remethylation.	Folic Acid	229-235	serine hydroxymethyltransferase 1	Homo sapiens	0-43
17702748-1	2007	Cytoplasmic serine hydroxymethyltransferase (cSHMT) enzyme levels are elevated by the expression of the heavy chain ferritin (H ferritin) cDNA in cultured cells without corresponding changes in mRNA levels, resulting in enhanced folate-dependent de novo thymidylate biosynthesis and impaired homocysteine remethylation.	Folic Acid	229-235	serine hydroxymethyltransferase 1	Homo sapiens	45-50
17979543-1	2007	Folate biochemical pathway components such as FR-alpha are determinants of response to novel antifolate drugs such as pemetrexed.	Folic Acid	0-6	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	46-54
17446347-0	2007	The spectrum of mutations in the PCFT gene, coding for an intestinal folate transporter, that are the basis for hereditary folate malabsorption.	Folic Acid	69-75	solute carrier family 46 member 1	Homo sapiens	33-37
17504266-0	2007	Folate deprivation increases presenilin expression, gamma-secretase activity, and Abeta levels in murine brain: potentiation by ApoE deficiency and alleviation by dietary S-adenosyl methionine.	Folic Acid	0-6	amyloid beta (A4) precursor protein	Mus musculus	82-87
17504266-3	2007	We demonstrate herein that dietary deficiency in folate and vitamin E, coupled pro-oxidant stress induced by dietary iron, increased presenilin-1 expression, gamma-secretase activity, and Abeta levels in normal adult mice.	Folic Acid	49-55	presenilin 1	Mus musculus	133-145
17504266-3	2007	We demonstrate herein that dietary deficiency in folate and vitamin E, coupled pro-oxidant stress induced by dietary iron, increased presenilin-1 expression, gamma-secretase activity, and Abeta levels in normal adult mice.	Folic Acid	49-55	amyloid beta (A4) precursor protein	Mus musculus	188-193
17475902-6	2007	These functional features of hPCFT/HCP1 are consistent with those of the well characterized carrier-mediated folate transport system in the small intestine, suggesting that hPCFT/HCP1 is responsible for the intestinal absorption of folate and also MTX.	Folic Acid	109-115	solute carrier family 46 member 1	Homo sapiens	29-34
17475902-6	2007	These functional features of hPCFT/HCP1 are consistent with those of the well characterized carrier-mediated folate transport system in the small intestine, suggesting that hPCFT/HCP1 is responsible for the intestinal absorption of folate and also MTX.	Folic Acid	109-115	solute carrier family 46 member 1	Homo sapiens	35-39
17475902-6	2007	These functional features of hPCFT/HCP1 are consistent with those of the well characterized carrier-mediated folate transport system in the small intestine, suggesting that hPCFT/HCP1 is responsible for the intestinal absorption of folate and also MTX.	Folic Acid	109-115	solute carrier family 46 member 1	Homo sapiens	173-178
17475902-6	2007	These functional features of hPCFT/HCP1 are consistent with those of the well characterized carrier-mediated folate transport system in the small intestine, suggesting that hPCFT/HCP1 is responsible for the intestinal absorption of folate and also MTX.	Folic Acid	109-115	solute carrier family 46 member 1	Homo sapiens	179-183
17475902-6	2007	These functional features of hPCFT/HCP1 are consistent with those of the well characterized carrier-mediated folate transport system in the small intestine, suggesting that hPCFT/HCP1 is responsible for the intestinal absorption of folate and also MTX.	Folic Acid	232-238	solute carrier family 46 member 1	Homo sapiens	29-34
17475902-6	2007	These functional features of hPCFT/HCP1 are consistent with those of the well characterized carrier-mediated folate transport system in the small intestine, suggesting that hPCFT/HCP1 is responsible for the intestinal absorption of folate and also MTX.	Folic Acid	232-238	solute carrier family 46 member 1	Homo sapiens	35-39
17475902-6	2007	These functional features of hPCFT/HCP1 are consistent with those of the well characterized carrier-mediated folate transport system in the small intestine, suggesting that hPCFT/HCP1 is responsible for the intestinal absorption of folate and also MTX.	Folic Acid	232-238	solute carrier family 46 member 1	Homo sapiens	173-178
17475902-6	2007	These functional features of hPCFT/HCP1 are consistent with those of the well characterized carrier-mediated folate transport system in the small intestine, suggesting that hPCFT/HCP1 is responsible for the intestinal absorption of folate and also MTX.	Folic Acid	232-238	solute carrier family 46 member 1	Homo sapiens	179-183
17475902-7	2007	We also found that sulfasalazine is a potent inhibitor of hPCFT/HCP1, which would interfere with the intestinal absorption of MTX when coadministered in therapy for rheumatoid arthritis as well as folate.	Folic Acid	197-203	solute carrier family 46 member 1	Homo sapiens	58-63
17475902-7	2007	We also found that sulfasalazine is a potent inhibitor of hPCFT/HCP1, which would interfere with the intestinal absorption of MTX when coadministered in therapy for rheumatoid arthritis as well as folate.	Folic Acid	197-203	solute carrier family 46 member 1	Homo sapiens	64-68
17550420-9	2007	We conclude that pterin aldehyde salvage in plants involves multiple, generalist NADPH-linked reductases, and that the At1g10310 enzyme is typical of these and hence suitable for use in engineering studies of folate turnover.	Folic Acid	209-215	NAD(P)-binding Rossmann-fold superfamily protein	Arabidopsis thaliana	119-128
17627246-6	2007	Folate-sensitive pathways may play a critical role in the elevated rate of SCC in renal transplant recipients.	Folic Acid	0-6	serpin family B member 3	Homo sapiens	75-78
17537830-6	2007	After CCK stimulation, a significant decrease in amylase, lipase and chymotrypsin activities in the duodenal juice were detected in ethanol, this trend was partially corrected with folate supplementation.	Folic Acid	181-187	lipase G, endothelial type	Rattus norvegicus	58-64
17537830-7	2007	CONCLUSION: Ethanol exerts its action on exocrine pancreatic secretion by two pathways: "per se" and diminishing the folic acid content, because a folic acid supplement in rats during pregnancy and lactation periods produces an advantageous effect on amylase, lipase and chymotrypsin secretion in their offspring.	Folic Acid	147-157	lipase G, endothelial type	Rattus norvegicus	260-266
17446168-7	2007	The three folate-dependent enzymes that constitute the de novo thymidylate biosynthesis pathway, cSHMT, thymidylate synthase, and dihydrofolate reductase, all contain SUMO modification consensus sequences.	Folic Acid	10-16	serine hydroxymethyltransferase 1	Homo sapiens	97-102
17446168-7	2007	The three folate-dependent enzymes that constitute the de novo thymidylate biosynthesis pathway, cSHMT, thymidylate synthase, and dihydrofolate reductase, all contain SUMO modification consensus sequences.	Folic Acid	10-16	thymidylate synthetase	Homo sapiens	104-124
17446168-7	2007	The three folate-dependent enzymes that constitute the de novo thymidylate biosynthesis pathway, cSHMT, thymidylate synthase, and dihydrofolate reductase, all contain SUMO modification consensus sequences.	Folic Acid	10-16	dihydrofolate reductase	Homo sapiens	130-153
17446168-8	2007	Compartmentation of the folate-dependent de novo thymidylate biosynthesis pathway in the nucleus accounts for the preferential partitioning of cSHMT-derived folate-activated one-carbon units into thymidylate biosynthesis; the efficiency of nuclear folate metabolism is likely to be modified by the cSHMT L474F polymorphism.	Folic Acid	24-30	serine hydroxymethyltransferase 1	Homo sapiens	143-148
17446168-8	2007	Compartmentation of the folate-dependent de novo thymidylate biosynthesis pathway in the nucleus accounts for the preferential partitioning of cSHMT-derived folate-activated one-carbon units into thymidylate biosynthesis; the efficiency of nuclear folate metabolism is likely to be modified by the cSHMT L474F polymorphism.	Folic Acid	24-30	serine hydroxymethyltransferase 1	Homo sapiens	298-303
17446168-8	2007	Compartmentation of the folate-dependent de novo thymidylate biosynthesis pathway in the nucleus accounts for the preferential partitioning of cSHMT-derived folate-activated one-carbon units into thymidylate biosynthesis; the efficiency of nuclear folate metabolism is likely to be modified by the cSHMT L474F polymorphism.	Folic Acid	157-163	serine hydroxymethyltransferase 1	Homo sapiens	143-148
17446168-8	2007	Compartmentation of the folate-dependent de novo thymidylate biosynthesis pathway in the nucleus accounts for the preferential partitioning of cSHMT-derived folate-activated one-carbon units into thymidylate biosynthesis; the efficiency of nuclear folate metabolism is likely to be modified by the cSHMT L474F polymorphism.	Folic Acid	157-163	serine hydroxymethyltransferase 1	Homo sapiens	298-303
17446168-8	2007	Compartmentation of the folate-dependent de novo thymidylate biosynthesis pathway in the nucleus accounts for the preferential partitioning of cSHMT-derived folate-activated one-carbon units into thymidylate biosynthesis; the efficiency of nuclear folate metabolism is likely to be modified by the cSHMT L474F polymorphism.	Folic Acid	157-163	serine hydroxymethyltransferase 1	Homo sapiens	143-148
17446168-8	2007	Compartmentation of the folate-dependent de novo thymidylate biosynthesis pathway in the nucleus accounts for the preferential partitioning of cSHMT-derived folate-activated one-carbon units into thymidylate biosynthesis; the efficiency of nuclear folate metabolism is likely to be modified by the cSHMT L474F polymorphism.	Folic Acid	157-163	serine hydroxymethyltransferase 1	Homo sapiens	298-303
17052775-3	2007	The aim of this study was to evaluate the effect of folic acid treatment on the evolution of CIMT in patients with coronary disease and homocysteinemia &gt; or =9 micromol/l.	Folic Acid	52-62	CIMT	Homo sapiens	93-97
17600497-1	2007	Folypolyglutamate synthetase (FPGS) plays a critical role in the cellular retention of both folates and antifolates.	Folic Acid	92-99	folylpolyglutamate synthase	Homo sapiens	0-28
17600497-1	2007	Folypolyglutamate synthetase (FPGS) plays a critical role in the cellular retention of both folates and antifolates.	Folic Acid	92-99	folylpolyglutamate synthase	Homo sapiens	30-34
17482424-0	2007	Folic acid supplementation affects ROS scavenging enzymes, enhances Vegf-A, and diminishes apoptotic state in yolk sacs of embryos of diabetic rats.	Folic Acid	0-10	vascular endothelial growth factor A	Rattus norvegicus	68-74
17439143-2	2007	Trienzyme extraction is a combined enzymatic digestion by protease, alpha-amylase, and conjugase (gamma-glutamyl hydrolase) to liberate the carbohydrate and protein-bound folates from food matrices for total folate analysis.	Folic Acid	171-178	gamma-glutamyl hydrolase	Homo sapiens	98-122
17439143-2	2007	Trienzyme extraction is a combined enzymatic digestion by protease, alpha-amylase, and conjugase (gamma-glutamyl hydrolase) to liberate the carbohydrate and protein-bound folates from food matrices for total folate analysis.	Folic Acid	171-177	gamma-glutamyl hydrolase	Homo sapiens	98-122
17290389-1	2007	Thymidylate synthase (TS) is a key enzyme in folate metabolism, a pathway that is important in colorectal carcinogenesis.	Folic Acid	45-51	thymidylate synthetase	Homo sapiens	0-20
17290389-1	2007	Thymidylate synthase (TS) is a key enzyme in folate metabolism, a pathway that is important in colorectal carcinogenesis.	Folic Acid	45-51	thymidylate synthetase	Homo sapiens	22-24
16963246-6	2007	However, in both Mtr groups of mice, dietary folate deficiency significantly increased adenoma number (from 32.3+/-3.8 on a CD to 48.1+/-4.2 on a folate-deficient diet), increased plasma homocysteine, decreased global DNA methylation in preneoplastic intestines and increased apoptosis in tissues.	Folic Acid	45-51	telomerase RNA component	Mus musculus	17-20
17413111-2	2007	Folic acid from multivitamins needs to be reduced by DHFR before it participates in cellular reactions.	Folic Acid	0-10	dihydrofolate reductase	Homo sapiens	53-57
17286298-4	2007	We also performed a dose-response study with folinic acid and determined the impact of maternal folate supplementation on Folr1 nullizygous cardiac development.	Folic Acid	96-102	folate receptor 1 (adult)	Mus musculus	122-127
17349072-8	2007	This study demonstrates that decreased homocysteinaemia by CEE therapy parallels with increased genomic DNA methylation, suggesting a potential new candidate mechanism by which ERT affects the risk of cancers and a possible new candidate biomarker for the oestrogen-related carcinogenesis through folate-related one-carbon metabolism.	Folic Acid	297-303	E74 like ETS transcription factor 3	Homo sapiens	177-180
26443588-2	2007	All the folic acid derivatives that serve as recipients and donors of one-carbon units are derivatives of tetrahydrofolate, which is formed from dihydrofolate by an NADPH-dependent reduction catalyzed by dihydrofolate reductase (FolA).	Folic Acid	8-18	dihydrofolate reductase type I	Escherichia coli	229-233
17360897-10	2007	Remarkably, hyperhomocysteinemia induced in wild-type and cystathionine-beta-synthase +/- mice by feeding a high-methionine, low-folate diet is associated with increased brain S-adenosylhomocysteine levels, PPMT downregulation, reduced PP2A methylation levels, and tau and APP phosphorylation.	Folic Acid	129-135	cystathionine beta-synthase	Mus musculus	58-85
17333344-5	2007	(Anti)folates are retained intracellularly via polyglutamylation catalyzed by folylpoly-gamma-glutamate synthetase (FPGS).	Folic Acid	6-13	folylpolyglutamate synthase	Homo sapiens	78-114
17333344-5	2007	(Anti)folates are retained intracellularly via polyglutamylation catalyzed by folylpoly-gamma-glutamate synthetase (FPGS).	Folic Acid	6-13	folylpolyglutamate synthase	Homo sapiens	116-120
17340171-7	2007	This article reviews (1) the characteristics and prevalence of the low-pH folate transport activity, (2) its relationship to, and properties of, the recently identified Proton-Coupled Folate Transporter (PCFT), (3) the physiological and pharmacological roles of this transporter, particularly with respect to pemetrexed, and (4) the historical controversy, now resolved, on the mechanism of intestinal folate absorption.	Folic Acid	74-80	solute carrier family 46 member 1	Homo sapiens	169-202
16884772-3	2007	We identified in FPGS from CEM-p cells three amino acid substitutions that altered the ATP binding P-loop, glutamate/folate binding, and a conserved domain located at the carboxyl-terminal.	Folic Acid	117-123	folylpolyglutamate synthase	Homo sapiens	17-21
17158459-3	2007	GNMT also links utilization of preformed methyl groups, in the form of methionine, to their de novo synthesis, because it is inhibited by a specific form of folate, 5-methyltetrahydrofolate.	Folic Acid	157-163	glycine N-methyltransferase	Rattus norvegicus	0-4
17158459-6	2007	In the GNMT-folate complex, two folate binding sites were located in the intersubunit areas of the tetramer.	Folic Acid	12-18	glycine N-methyltransferase	Rattus norvegicus	7-11
17158459-9	2007	Binding experiments in solution also confirm that one GNMT tetramer binds two folate molecules.	Folic Acid	78-84	glycine N-methyltransferase	Rattus norvegicus	54-58
17308042-3	2007	These include (a) its very rapid conversion to active polyglutamate derivatives in cells that build to high levels and are retained for long intervals to achieve prolonged and potent inhibition of its major target enzyme thymidylate synthase, (b) its high affinity for three folate transporters, and (c) its marked sensitivity to the level of physiologic folates in cells.	Folic Acid	355-362	thymidylate synthetase	Homo sapiens	221-241
17308042-5	2007	This is due to concurrent contraction of competing cellular physiologic folates and utilization of a novel second transport carrier for which pemetrexed has high affinity, recently identified as the proton-coupled folate transporter (PCFT).	Folic Acid	72-79	solute carrier family 46 member 1	Homo sapiens	199-232
17308042-5	2007	This is due to concurrent contraction of competing cellular physiologic folates and utilization of a novel second transport carrier for which pemetrexed has high affinity, recently identified as the proton-coupled folate transporter (PCFT).	Folic Acid	72-79	solute carrier family 46 member 1	Homo sapiens	234-238
17520086-2	2007	One pathway is triggered by testosterone via the intracellular androgen receptor, AR, and the other is induced by antifolate CB 3717 or folate via hepatocyte growth factor and its cell membrane receptor c-Met.	Folic Acid	118-124	met proto-oncogene	Mus musculus	203-208
16969375-2	2007	The gene dihydrofolate reductase (DHFR) is primarily involved in the reduction of dihydrofolate, generated during thymidylate synthesis, to tetrahydrofolate in order to maintain adequate amounts of folate for DNA synthesis and homocysteine remethylation.	Folic Acid	16-22	dihydrofolate reductase	Homo sapiens	34-38
17392017-6	2007	Recent links between NAT1 genotypes and susceptibility to spina bifida suggests that the enzyme has an important role in folate homeostasis.	Folic Acid	121-127	N-acetyltransferase 1	Homo sapiens	21-25
17108120-7	2006	The miRNA hsa-miR-222 was identified from these arrays as significantly overexpressed under folate-deficient conditions, and this finding was confirmed in vivo in human peripheral blood from individuals with low folate intake.	Folic Acid	92-98	microRNA 222	Homo sapiens	14-21
17108120-7	2006	The miRNA hsa-miR-222 was identified from these arrays as significantly overexpressed under folate-deficient conditions, and this finding was confirmed in vivo in human peripheral blood from individuals with low folate intake.	Folic Acid	212-218	microRNA 222	Homo sapiens	14-21
21371789-5	2011	In this study, the interaction mode of SHMT with pemetrexed, an antifolate drug inhibiting several enzymes involved in folate-dependent biosynthetic pathways, was assessed.	Folic Acid	68-74	serine hydroxymethyltransferase 1	Homo sapiens	39-43
19329227-3	2011	Aim of present study was to analyze the methylation pattern of PSEN1 promoter in SK-N-BE neuroblastoma cells and TgCRND8 mice, in a B vitamin (folate, B12 and B6) deficiency paradigm.	Folic Acid	143-149	presenilin 1	Mus musculus	63-68
20857335-10	2010	Mutation screening in the FOLR1 gene is advisable in children with profound 5MTHF deficiency and decreased CSF/serum folate ratio.	Folic Acid	117-123	folate receptor alpha	Homo sapiens	26-31
20737153-2	2010	MATERIALS AND METHODS: We developed a novel liposome-MYCN siRNA-folic acid complex, and the transfection efficacy was measured in LA-N-5 cells by cy-3 fluorescence density in each microgram of protein from the transfected cell lysate.	Folic Acid	64-74	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	53-57
21215183-11	2010	In folic acid deficient group, the expressions of tbx5 and nppa were reduced while the expressions of vmhc and amhc appeared normal.	Folic Acid	3-13	T-box transcription factor 5a	Danio rerio	50-54
21301589-2	2010	Antifolates are inhibitors of key enzymes in folate metabolism, namely dihydrofolate reductase, beta-glycinamide ribonucleotide transformylase, 5"-amino-4"-imidazolecarboxamide ribonucleotide transformylase, and thymidylate synthetase.	Folic Acid	4-10	dihydrofolate reductase	Homo sapiens	71-94
20624932-3	2010	Here, we report a novel function of glutamate carboxypeptidase II (GCPII) in Abeta degradation in brain, which is a peptidase involved in N-acetylaspartylglutamate cleavage, folate metabolism, and prostate tumorigenesis.	Folic Acid	174-180	amyloid beta (A4) precursor protein	Mus musculus	77-82
20844350-8	2010	The possible epigenetic role of folate in Wnt/beta-catenin signaling is described.	Folic Acid	32-38	catenin beta 1	Homo sapiens	46-58
20601456-2	2010	We tested 6-substituted pyrrolo[2,3-d]pyrimidine antifolates with one to six carbons in the bridge region for inhibition of proliferation in isogenic Chinese hamster ovary (CHO) and HeLa cells expressing PCFT or reduced folate carrier (RFC).	Folic Acid	53-59	solute carrier family 46 member 1	Homo sapiens	204-208
20846364-14	2010	In line with our hypothesis, when Hif1alpha expression level is restored (by supplementation of folic acid), a decrement of CHD is found.	Folic Acid	96-106	hypoxia inducible factor 1, alpha subunit	Mus musculus	34-43
19816791-3	2010	The focus of this study was to deliver the dihydrofolate reductase (DHFR) siRNA expressing plasmid and to silence the DHFR gene in FR positive KB cells, by complexing the plasmid with a folate-polyethylene glycol-polyethylenimine (FOL-PEG-PEI) conjugate, as a gene carrier.	Folic Acid	50-56	dihydrofolate reductase	Homo sapiens	68-72
19816791-3	2010	The focus of this study was to deliver the dihydrofolate reductase (DHFR) siRNA expressing plasmid and to silence the DHFR gene in FR positive KB cells, by complexing the plasmid with a folate-polyethylene glycol-polyethylenimine (FOL-PEG-PEI) conjugate, as a gene carrier.	Folic Acid	50-56	dihydrofolate reductase	Homo sapiens	118-122
20350571-6	2010	Of the substrates tested in FPGS assays, only tetrahydrofolate (THF) was efficiently converted to polyglutamylated forms, exhibiting standard kinetics with an apparent K(m) of 0.96microM; dihydrofolate, folate and the folate analogue methotrexate (MTX) were negligibly processed, emphasising the importance of the oxidation state of the pterin moiety.	Folic Acid	56-62	folylpolyglutamate synthase	Homo sapiens	28-32
20350571-10	2010	This, combined with the absence of DHFS activity in humans, suggests PfDHFS-FPGS might represent a potential new drug target in the previously validated folate pathway of P. falciparum.	Folic Acid	153-159	folylpolyglutamate synthase	Homo sapiens	76-80
20360131-5	2010	Both the reduced folate carrier (RFC) and the proton-coupled folate transporter (PCFT) were found to be expressed in AR42J and in primary pancreatic acinar cells, as well as in native human pancreas with expression of RFC being higher than PCFT.	Folic Acid	17-23	solute carrier family 46 member 1	Homo sapiens	240-244
19952865-10	2010	In conclusion, high maternal autoantibody levels and blocking of folate binding to FRalpha in maternal serum during pregnancy are not associated with an increased risk of oral clefts in the offspring in this population-based cohort.	Folic Acid	65-71	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	83-90
19932120-9	2010	SIGNIFICANCE: Since increasing NAT1 activity decreases folate in at least one tissue, the detrimental effect of expression of human NAT1 in combination with endogenous mouse Nat2 may be a consequence of increased catabolism of folate.	Folic Acid	55-61	N-acetyltransferase 1	Homo sapiens	31-35
19932120-9	2010	SIGNIFICANCE: Since increasing NAT1 activity decreases folate in at least one tissue, the detrimental effect of expression of human NAT1 in combination with endogenous mouse Nat2 may be a consequence of increased catabolism of folate.	Folic Acid	227-233	N-acetyltransferase 1	Homo sapiens	132-136
19360465-3	2010	Of the analyzed genes, ERCC2, XRCC1, XRCC2, XRCC3 and Lig4 participate in DNA repair, TP53 in cell cycle check point control, AIB1, AR, COMT, CYP11A1, CYP17A1, CYP19A1, HSD17 and PGR in steroid hormone biosynthesis/metabolism/signaling, TYMS in folate metabolism and HER2, IL6, LRP1, TGFB and TGFBR1 affect cell growth.	Folic Acid	245-251	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	23-28
19360465-3	2010	Of the analyzed genes, ERCC2, XRCC1, XRCC2, XRCC3 and Lig4 participate in DNA repair, TP53 in cell cycle check point control, AIB1, AR, COMT, CYP11A1, CYP17A1, CYP19A1, HSD17 and PGR in steroid hormone biosynthesis/metabolism/signaling, TYMS in folate metabolism and HER2, IL6, LRP1, TGFB and TGFBR1 affect cell growth.	Folic Acid	245-251	DNA ligase 4	Homo sapiens	54-58
19360465-3	2010	Of the analyzed genes, ERCC2, XRCC1, XRCC2, XRCC3 and Lig4 participate in DNA repair, TP53 in cell cycle check point control, AIB1, AR, COMT, CYP11A1, CYP17A1, CYP19A1, HSD17 and PGR in steroid hormone biosynthesis/metabolism/signaling, TYMS in folate metabolism and HER2, IL6, LRP1, TGFB and TGFBR1 affect cell growth.	Folic Acid	245-251	thymidylate synthetase	Homo sapiens	237-241
19360465-3	2010	Of the analyzed genes, ERCC2, XRCC1, XRCC2, XRCC3 and Lig4 participate in DNA repair, TP53 in cell cycle check point control, AIB1, AR, COMT, CYP11A1, CYP17A1, CYP19A1, HSD17 and PGR in steroid hormone biosynthesis/metabolism/signaling, TYMS in folate metabolism and HER2, IL6, LRP1, TGFB and TGFBR1 affect cell growth.	Folic Acid	245-251	transforming growth factor beta receptor 1	Homo sapiens	293-299
19954435-8	2010	The inhibitor binds to the human heme oxygenase-1 distal pocket through the coordination of heme iron by the N4 in the triazole moiety, whereas the phenyl group is stabilized by hydrophobic interactions from residues within the binding pocket.	Folic Acid	109-111	heme oxygenase 1	Homo sapiens	33-49
19839928-1	2010	Pemetrexed is a multi-targeted anti metabolite that inhibits several key folate-dependent enzymes in the thymidine and purine biosynthetic pathways, including thymidylate synthase.	Folic Acid	73-79	thymidylate synthetase	Homo sapiens	159-179
21058196-7	2010	The association between ATM diplotype and the breast cancer risk was predominantly among women with low intake of antioxidant vitamins including vitamin A, vitamin C, and folic acid.	Folic Acid	171-181	ATM serine/threonine kinase	Homo sapiens	24-27
20030974-2	2009	For the purpose of achieving further information we analyzed ligand (folate and methotrexate)-induced changes in the fluorescence landscape of FBP.	Folic Acid	69-75	folate receptor alpha	Bos taurus	143-146
20030974-7	2009	The sharp decrease in hydrophobicity at pI=7-8 following binding of folate accords fairly well with the disappearance of strongly hydrophobic tryptophan residues from the solvent-exposed surface of FBP.	Folic Acid	68-74	folate receptor alpha	Bos taurus	198-201
20030974-8	2009	The PARAFAC has thus proven useful to establish a hitherto unexplained link between parallel changes in conformational structure and physico-chemical characteristics of FBP induced by folate binding.	Folic Acid	184-190	folate receptor alpha	Bos taurus	169-172
20030974-11	2009	This could suggest a rapid and firm complexation of folate to FBP, blocking access of competing ligands.	Folic Acid	52-58	folate receptor alpha	Bos taurus	62-65
19764999-8	2009	Folate levels in tumors correlated positively with LINE-1, CDH13, and RUNX3 methylation.	Folic Acid	0-6	RUNX family transcription factor 3	Homo sapiens	70-75
19842618-2	2009	NAT1 also catalyzes the N-acetylation of 4-aminobenzoylglutamic acid, a product of folic acid degradation, and is associated with endogenous functions in embryonic development.	Folic Acid	83-93	N-acetyltransferase 1	Homo sapiens	0-4
19740703-1	2009	Hereditary folate malabsorption is a rare inborn error of metabolism due to mutations in the proton-coupled folate transporter (PCFT).	Folic Acid	11-17	solute carrier family 46 member 1	Homo sapiens	128-132
20025500-1	2009	Folate biochemical pathway enzymes such as folylpolyglutamate synthetase (FPGS) are key elements in the folate pathway.	Folic Acid	0-6	folylpolyglutamate synthase	Homo sapiens	43-72
20025500-1	2009	Folate biochemical pathway enzymes such as folylpolyglutamate synthetase (FPGS) are key elements in the folate pathway.	Folic Acid	0-6	folylpolyglutamate synthase	Homo sapiens	74-78
20025500-1	2009	Folate biochemical pathway enzymes such as folylpolyglutamate synthetase (FPGS) are key elements in the folate pathway.	Folic Acid	104-110	folylpolyglutamate synthase	Homo sapiens	43-72
20025500-1	2009	Folate biochemical pathway enzymes such as folylpolyglutamate synthetase (FPGS) are key elements in the folate pathway.	Folic Acid	104-110	folylpolyglutamate synthase	Homo sapiens	74-78
20025500-2	2009	The role of FPGS is to add glutamate residues to folates and antifolates, trapping them in the cell and increasing their affinity for subsequent enzymatic reactions.	Folic Acid	49-56	folylpolyglutamate synthase	Homo sapiens	12-16
19924280-0	2009	Periconceptional maternal folic acid use of 400 microg per day is related to increased methylation of the IGF2 gene in the very young child.	Folic Acid	26-36	insulin like growth factor 2	Homo sapiens	106-110
19924280-7	2009	Children of mother who used folic acid had a 4.5% higher methylation of the IGF2 DMR than children who were not exposed to folic acid (49.5% vs. 47.4%; p = 0.014).	Folic Acid	28-38	insulin like growth factor 2	Homo sapiens	76-80
19924280-10	2009	CONCLUSIONS: Periconceptional folic acid use is associated with epigenetic changes in IGF2 in the child that may affect intrauterine programming of growth and development with consequences for health and disease throughout life.	Folic Acid	30-40	insulin like growth factor 2	Homo sapiens	86-90
19924280-11	2009	These results indicate plasticity of IGF2 methylation by periconceptional folic acid use.	Folic Acid	74-84	insulin like growth factor 2	Homo sapiens	37-41
19734144-5	2009	The UV-induced increase in SHMT1 translation is accompanied by an increase in the small ubiquitin-like modifier-dependent nuclear localization of the de novo thymidylate biosynthesis pathway and a decrease in DNA strand breaks, indicating a role for SHMT1 and nuclear folate metabolism in DNA repair.	Folic Acid	268-274	serine hydroxymethyltransferase 1	Homo sapiens	27-32
19666701-2	2009	Availability of dietary folates is determined by their absorption across the intestinal epithelium, mediated by the proton-coupled folate transporter (PCFT) at the apical enterocyte membranes.	Folic Acid	24-31	solute carrier family 46 member 1	Homo sapiens	116-149
19666701-2	2009	Availability of dietary folates is determined by their absorption across the intestinal epithelium, mediated by the proton-coupled folate transporter (PCFT) at the apical enterocyte membranes.	Folic Acid	24-31	solute carrier family 46 member 1	Homo sapiens	151-155
19666701-11	2009	In conclusion, vitamin D(3) and VDR increase intestinal PCFT expression, resulting in enhanced cellular folate uptake.	Folic Acid	104-110	solute carrier family 46 member 1	Homo sapiens	56-60
19625220-0	2009	Folate/homocysteine phenotypes and MTHFR 677C&gt;T genotypes are associated with serum levels of monocyte chemoattractant protein-1.	Folic Acid	0-6	C-C motif chemokine ligand 2	Homo sapiens	97-131
19732866-3	2009	We identified an inherited brain-specific folate transport defect that is caused by mutations in the folate receptor 1 (FOLR1) gene coding for folate receptor alpha (FRalpha).	Folic Acid	42-48	folate receptor alpha	Homo sapiens	101-118
19732866-3	2009	We identified an inherited brain-specific folate transport defect that is caused by mutations in the folate receptor 1 (FOLR1) gene coding for folate receptor alpha (FRalpha).	Folic Acid	42-48	folate receptor alpha	Homo sapiens	120-125
19732866-3	2009	We identified an inherited brain-specific folate transport defect that is caused by mutations in the folate receptor 1 (FOLR1) gene coding for folate receptor alpha (FRalpha).	Folic Acid	42-48	folate receptor alpha	Homo sapiens	143-164
19732866-3	2009	We identified an inherited brain-specific folate transport defect that is caused by mutations in the folate receptor 1 (FOLR1) gene coding for folate receptor alpha (FRalpha).	Folic Acid	42-48	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	166-173
19732866-4	2009	Three patients carrying FOLR1 mutations developed progressive movement disturbance, psychomotor decline, and epilepsy and showed severely reduced folate concentrations in the cerebrospinal fluid (CSF).	Folic Acid	146-152	folate receptor alpha	Homo sapiens	24-29
19732866-6	2009	Retroviral transfection of patient cells with either FRalpha or FRbeta could rescue folate binding.	Folic Acid	84-90	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	53-60
19732866-6	2009	Retroviral transfection of patient cells with either FRalpha or FRbeta could rescue folate binding.	Folic Acid	84-90	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	64-70
20049736-8	2009	This suggested that the ability of methotrexate to modulate folate synthesis via inhibition of DHFR, may explain MSH2 selectivity.	Folic Acid	60-66	dihydrofolate reductase	Homo sapiens	95-99
19719239-4	2009	X-ray crystal structures of 2 and 1 (the 6-methyl analogue of 2), DHFR, and NADPH showed for the first time that the thieno[2,3-d]pyrimidine ring binds in a "folate" mode.	Folic Acid	158-164	dihydrofolate reductase	Homo sapiens	66-70
19457069-3	2009	Previous studies demonstrate that deprivation of folate and vitamin E, coupled with dietary iron as a pro-oxidant, for 1 month displayed increased presenilin 1 (PS-1) expression, gamma-secretase, and Abeta generation in mice lacking ApoE (ApoE-/- mice).	Folic Acid	49-55	presenilin 1	Mus musculus	147-159
19457069-3	2009	Previous studies demonstrate that deprivation of folate and vitamin E, coupled with dietary iron as a pro-oxidant, for 1 month displayed increased presenilin 1 (PS-1) expression, gamma-secretase, and Abeta generation in mice lacking ApoE (ApoE-/- mice).	Folic Acid	49-55	presenilin 1	Mus musculus	161-165
19669235-6	2009	This compliments previous reports that folate is important for milk protein synthesis and suggests FOLR1 may be a key regulatory point of folate metabolism for milk protein synthesis within mammary epithelial cells (lactocytes).	Folic Acid	138-144	folate receptor alpha	Bos taurus	99-104
19530270-2	2009	The cytotoxic T-lymphocyte antigen 4 (CTLA-4) gene was recently associated with AITD and PGA, and the CTLA-4 protein is a strong inhibitor of T-cells.The tumor necrosis factor alpha (TNF-alpha) is a proinflammatory cytokine.	Folic Acid	89-92	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	4-36
19530270-2	2009	The cytotoxic T-lymphocyte antigen 4 (CTLA-4) gene was recently associated with AITD and PGA, and the CTLA-4 protein is a strong inhibitor of T-cells.The tumor necrosis factor alpha (TNF-alpha) is a proinflammatory cytokine.	Folic Acid	89-92	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	38-44
19530270-3	2009	This study aimed to analyze the association of the CTLA-4 CT60 and TNF-alpha-863 polymorphisms with PGA.	Folic Acid	100-103	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	51-57
19530270-9	2009	In conclusion the CTLA-4 CT60 polymorphism is associated with PGA.	Folic Acid	62-65	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	18-24
19174154-2	2009	This class is characterized by retention of dihydrofolate reductase (DHFR; EC 1.5.1.3) as their locus of action and transport by the reduced folate carrier (RFC; SLC19A1), but their lack of metabolism by known pathways of antifolate (e.g., methotrexate (MTX)) metabolism.	Folic Acid	51-57	dihydrofolate reductase	Homo sapiens	69-73
19174154-7	2009	In contrast, each weakly inhibits other enzymes of folate metabolism relevant to rheumatoid arthritis therapy (thymidylate synthase (EC 2.1.1.45), two formyltransferases of purine biosynthesis (EC 2.1.2.2 and EC 2.1.2.3), and 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)).	Folic Acid	51-57	thymidylate synthetase	Homo sapiens	111-131
19180647-3	2009	We have found that visceral endoderm cells express folate receptor 1, a high-affinity receptor for the essential micronutrient folic acid, suggesting that the visceral endoderm has an important function for folate transport to the embryo.	Folic Acid	127-137	folate receptor alpha	Homo sapiens	51-68
18985509-1	2008	Folic acid was derivatized specifically at its gamma-carboxyl group to retain its ligand-binding activity to the folate receptor alpha (FRalpha) present on HeLa cells.	Folic Acid	0-10	folate receptor alpha	Homo sapiens	113-134
18985509-1	2008	Folic acid was derivatized specifically at its gamma-carboxyl group to retain its ligand-binding activity to the folate receptor alpha (FRalpha) present on HeLa cells.	Folic Acid	0-10	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	136-143
18985509-10	2008	Therefore, folate-labeled amphiphiles show promise in targeting antitumor agents to FRalpha-expressing cancer cells.	Folic Acid	11-17	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	84-91
19022952-0	2008	A 19-base pair deletion polymorphism in dihydrofolate reductase is associated with increased unmetabolized folic acid in plasma and decreased red blood cell folate.	Folic Acid	107-117	dihydrofolate reductase	Homo sapiens	40-63
19022952-1	2008	Dihydrofolate reductase (DHFR) catalyzes the reduction of folic acid to tetrahydrofolate (THF).	Folic Acid	58-68	dihydrofolate reductase	Homo sapiens	0-23
19022952-1	2008	Dihydrofolate reductase (DHFR) catalyzes the reduction of folic acid to tetrahydrofolate (THF).	Folic Acid	58-68	dihydrofolate reductase	Homo sapiens	25-29
19022952-4	2008	The objective of this research was to determine the effects of the DHFR mutation with respect to folate status and assess influence of folic acid intake on these relations.	Folic Acid	97-103	dihydrofolate reductase	Homo sapiens	67-71
19022952-6	2008	There was a significant interaction between DHFR genotype and folic acid intake with respect to the prevalence of high circulating unmetabolized folic acid (defined as >85th percentile).	Folic Acid	145-155	dihydrofolate reductase	Homo sapiens	44-48
19022952-8	2008	Interaction between the DHFR polymorphism and folic acid intake was also seen with respect to RBC folate (P for interaction = 0.01).	Folic Acid	46-56	dihydrofolate reductase	Homo sapiens	24-28
19022952-8	2008	Interaction between the DHFR polymorphism and folic acid intake was also seen with respect to RBC folate (P for interaction = 0.01).	Folic Acid	98-104	dihydrofolate reductase	Homo sapiens	24-28
19022952-10	2008	Our results suggest the del/del polymorphism in DHFR is a functional polymorphism, because it limits assimilation of folic acid into cellular folate stores at high and low folic acid intakes.	Folic Acid	117-127	dihydrofolate reductase	Homo sapiens	48-52
19022952-10	2008	Our results suggest the del/del polymorphism in DHFR is a functional polymorphism, because it limits assimilation of folic acid into cellular folate stores at high and low folic acid intakes.	Folic Acid	142-148	dihydrofolate reductase	Homo sapiens	48-52
19022952-10	2008	Our results suggest the del/del polymorphism in DHFR is a functional polymorphism, because it limits assimilation of folic acid into cellular folate stores at high and low folic acid intakes.	Folic Acid	172-182	dihydrofolate reductase	Homo sapiens	48-52
19178683-2	2008	Folate and homocysteine derangements are identified in people diagnosed with head and neck SCC.	Folic Acid	0-6	serpin family B member 3	Homo sapiens	91-94
18817749-1	2008	The proton-coupled folate transporter (PCFT/SLC46A1) displays optimal and prominent folate and antifolate transport activity at acidic pH in human carcinoma cells but poor activity in leukemia cells.	Folic Acid	19-25	solute carrier family 46 member 1	Homo sapiens	39-43
18817749-1	2008	The proton-coupled folate transporter (PCFT/SLC46A1) displays optimal and prominent folate and antifolate transport activity at acidic pH in human carcinoma cells but poor activity in leukemia cells.	Folic Acid	19-25	solute carrier family 46 member 1	Homo sapiens	44-51
18177869-0	2008	Association between folate metabolism-related gene polymorphisms and methylation of p16(INK4A) and hMLH1 genes in spontaneously aborted embryos with normal chromosomal integrity.	Folic Acid	20-26	mutL homolog 1	Homo sapiens	99-104
17537547-7	2008	A simultaneous supplement of folate and vitamin B12 restored partially the plasma homocysteine level and thus significantly antagonized the homocysteine-induced tau hyperphosphorylation and as well as PP2A inactivation and the activity-related modifications of PP2A(C).	Folic Acid	29-35	protein phosphatase 2 catalytic subunit alpha	Homo sapiens	261-268
18694733-3	2008	The results demonstrated that feeding a folate/methyl-deficient diet causes global DNA hypermethylation as indicated by an increase of genomic 5-methyl-2"-deoxycytidine (5mdC) content and more importantly, by an increase of methylation within unmethylated CpG-rich DNA domains.	Folic Acid	40-46	C-C motif chemokine ligand 22	Rattus norvegicus	171-174
18843658-19	2008	In one pilot trial enrolling people with Alzheimer"s disease, the overall response to cholinesterase inhibitors significantly improved with folic acid at a dose of 1mg/day (odds ratio: 4.06, 95% CI 1.22 to 13.53; P = 0.02) and there was a significant improvement in scores on the Instrumental Activities of Daily Living and the Social Behaviour subscale of the Nurse"s Observation Scale for Geriatric Patients (WMD 4.01, 95% CI 0.50 to 7.52, P = 0.02).	Folic Acid	140-150	butyrylcholinesterase	Homo sapiens	86-100
18843658-23	2008	In a preliminary study, folic acid was associated with improvement in the response of people with Alzheimer"s disease to cholinesterase inhibitors.	Folic Acid	24-34	butyrylcholinesterase	Homo sapiens	121-135
18842806-6	2008	DESIGN: Thirteen single nucleotide polymorphisms (SNPs) in genes involved in folate uptake and metabolism, including folate hydrolase (FOLH1), folate polyglutamate synthase (FPGS), gamma-glutamyl hydrolase (GGH), methylene tetrahydrofolate reductase (MTHFR), methionine synthase (MTR), proton-coupled folate transporter (PCFT), and reduced folate carrier (RFC1), were studied in a cohort of 991 individuals.	Folic Acid	77-83	gamma-glutamyl hydrolase	Homo sapiens	207-210
18842806-6	2008	DESIGN: Thirteen single nucleotide polymorphisms (SNPs) in genes involved in folate uptake and metabolism, including folate hydrolase (FOLH1), folate polyglutamate synthase (FPGS), gamma-glutamyl hydrolase (GGH), methylene tetrahydrofolate reductase (MTHFR), methionine synthase (MTR), proton-coupled folate transporter (PCFT), and reduced folate carrier (RFC1), were studied in a cohort of 991 individuals.	Folic Acid	77-83	solute carrier family 46 member 1	Homo sapiens	286-319
18842806-6	2008	DESIGN: Thirteen single nucleotide polymorphisms (SNPs) in genes involved in folate uptake and metabolism, including folate hydrolase (FOLH1), folate polyglutamate synthase (FPGS), gamma-glutamyl hydrolase (GGH), methylene tetrahydrofolate reductase (MTHFR), methionine synthase (MTR), proton-coupled folate transporter (PCFT), and reduced folate carrier (RFC1), were studied in a cohort of 991 individuals.	Folic Acid	77-83	solute carrier family 46 member 1	Homo sapiens	321-325
18070950-9	2008	Higher tHcy and lower folate concentrations correlated with impaired Delta RI(ALB) and increased CIMT.	Folic Acid	22-28	CIMT	Homo sapiens	97-101
18070950-10	2008	A 1 microg/l increase in folate concentration was associated with 0.3 (95% CI 0.1 to 0.5) percentage point increase in Delta RI(ALB) and 0.002 (95% CI 0.001 to 0.006) mm decrease in CIMT, independent of blood pressure, smoking and vascular risk profile.	Folic Acid	25-31	CIMT	Homo sapiens	182-186
17681772-4	2008	Expression of Folate Receptor 1 was increased with decreasing media folate in all cell lines, as was p53, p21, p16 and beta-catenin.	Folic Acid	68-74	folate receptor alpha	Homo sapiens	14-31
18247058-4	2008	The impact of the dihydrofolate reductase (DHFR) c.86 + 60_78 insertion/deletion (ins/del) polymorphism on folate and homocysteine concentrations was analyzed using data from healthy young adults from Northern Ireland, collected as part of visit three of the Young Hearts Project.	Folic Acid	25-31	dihydrofolate reductase	Homo sapiens	43-47
18247058-6	2008	Among women the DHFR c.86 + 60_78 polymorphism explained 2% of the variation in RBC folate levels and 5% of the variation in serum folate levels, but did not appear to have an independent effect on homocysteine.	Folic Acid	84-90	dihydrofolate reductase	Homo sapiens	16-20
18247058-6	2008	Among women the DHFR c.86 + 60_78 polymorphism explained 2% of the variation in RBC folate levels and 5% of the variation in serum folate levels, but did not appear to have an independent effect on homocysteine.	Folic Acid	131-137	dihydrofolate reductase	Homo sapiens	16-20
18247058-7	2008	Relative to women with the DHFR c.86 + 60_78 ins/ins and ins/del genotypes, del/del homozygotes had increased serum and red blood cell folate concentrations and may therefore be at decreased risk of having offspring affected by NTDs and of other adverse reproductive and health outcomes attributable to low folate.	Folic Acid	135-141	dihydrofolate reductase	Homo sapiens	27-31
18207707-0	2008	Degradable PEG-folate coated poly(DMAEA-co-BA)phosphazene-based polyplexes exhibit receptor-specific gene expression.	Folic Acid	15-21	progestagen associated endometrial protein	Homo sapiens	11-14
18207707-6	2008	When free folate was added to the transfection medium, only the transfection activity of the targeted polyplexes was reduced, indicating internalization of the targeted PEG polyplexes via the folate receptor.	Folic Acid	10-16	progestagen associated endometrial protein	Homo sapiens	169-172
18086128-3	2008	Choroid plexus epithelial cells express high levels of folate receptor alpha (FRalpha) suggesting that the choroid plays an important role in CNS folate trafficking and maintenance of CSF folate levels.	Folic Acid	146-152	folate receptor alpha	Rattus norvegicus	55-76
18256483-7	2008	Although thiamine pyrophosphate (TPP), a substrate of RFC, had no effect on folate uptake, hemin (a weak inhibitor of folate uptake via HCP1) decreased folate uptake to about 80% of the control level under an acidic buffer condition.	Folic Acid	118-124	solute carrier family 46 member 1	Homo sapiens	136-140
18256483-7	2008	Although thiamine pyrophosphate (TPP), a substrate of RFC, had no effect on folate uptake, hemin (a weak inhibitor of folate uptake via HCP1) decreased folate uptake to about 80% of the control level under an acidic buffer condition.	Folic Acid	118-124	solute carrier family 46 member 1	Homo sapiens	136-140
18256483-10	2008	RFC is not involved in folate uptake, but FRalpha (high affinity phase) and HCP1 (low affinity phase) transport folate in BeWo cells.	Folic Acid	112-118	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	42-49
18256483-10	2008	RFC is not involved in folate uptake, but FRalpha (high affinity phase) and HCP1 (low affinity phase) transport folate in BeWo cells.	Folic Acid	112-118	solute carrier family 46 member 1	Homo sapiens	76-80
17600848-0	2008	A randomised double-blind placebo-controlled trial of folic acid supplementation of cholinesterase inhibitors in Alzheimer"s disease.	Folic Acid	54-64	butyrylcholinesterase	Homo sapiens	84-98
17600848-1	2008	OBJECTIVES: (1) to assess the effect of 1 mg folic acid supplementation of cholinesterase inhibitors (ChI) in a 6 month double-blind placebo-controlled study of patients with Alzheimer"s Disease (AD) and (2) to assess whether outcome measures were affected by changes in homocysteine levels.	Folic Acid	45-55	butyrylcholinesterase	Homo sapiens	75-89
18035049-2	2008	We investigated the roles of folylpolyglutamate synthase (FPGS) and gamma-glutamyl hydrolase (GGH), which are the main enzymes involved in folate metabolism, in the effect of LV.	Folic Acid	139-145	gamma-glutamyl hydrolase	Homo sapiens	94-97
18035049-4	2008	Small-interfering RNA (siRNA) transfected into DLD-1 cells to downregulate FPGS reduced the basal level of reduced folate, the folate level after LV treatment, and the enhancement of 5-fluoro-2"-deoxyuridine (FdUrd)-induced cytotoxicity elicited by LV.	Folic Acid	115-121	folylpolyglutamate synthase	Homo sapiens	75-79
18035049-4	2008	Small-interfering RNA (siRNA) transfected into DLD-1 cells to downregulate FPGS reduced the basal level of reduced folate, the folate level after LV treatment, and the enhancement of 5-fluoro-2"-deoxyuridine (FdUrd)-induced cytotoxicity elicited by LV.	Folic Acid	127-133	folylpolyglutamate synthase	Homo sapiens	75-79
19850982-3	2008	To counteract these damage, a variety of DNA repair pathways have evolved that require regular supply of DNA bases whose biosynthesis in turn depends on sufficient pools of folate dependent enzymes like dihydrofolate reductase (DHFR).	Folic Acid	173-179	dihydrofolate reductase	Homo sapiens	203-226
19850982-3	2008	To counteract these damage, a variety of DNA repair pathways have evolved that require regular supply of DNA bases whose biosynthesis in turn depends on sufficient pools of folate dependent enzymes like dihydrofolate reductase (DHFR).	Folic Acid	173-179	dihydrofolate reductase	Homo sapiens	228-232
19850982-4	2008	In the present study, we examined the ionizing radiation mediated perturbation of DHFR activity in folate deficient and folate sufficient conditions.	Folic Acid	99-105	dihydrofolate reductase	Homo sapiens	82-86
19850982-4	2008	In the present study, we examined the ionizing radiation mediated perturbation of DHFR activity in folate deficient and folate sufficient conditions.	Folic Acid	120-126	dihydrofolate reductase	Homo sapiens	82-86
19850982-5	2008	In folate deficient animals a potent inhibition of liver DHFR activity was observed.	Folic Acid	3-9	dihydrofolate reductase	Homo sapiens	57-61
19850982-6	2008	Our results showed that combination of folate starvation and ionizing radiation might adversely affect the DHFR activity, compared to their individual treatments.	Folic Acid	39-45	dihydrofolate reductase	Homo sapiens	107-111
19850982-8	2008	In conclusion our data suggest an interactive role of folate deficiency and radiation injury in inhibiting DHFR activity.	Folic Acid	54-60	dihydrofolate reductase	Homo sapiens	107-111
18642144-8	2008	The mammalian NAT enzymes are involved in metabolism of drugs and carcinogens but there is growing evidence, including from transgenic mice, that human NAT1 has an endogenous role in folate degradation.	Folic Acid	183-189	N-acetyltransferase 1	Homo sapiens	152-156
18569587-10	2008	After implementation of the SNP into the model significant lower adjusted means of urinary PGA concentrations were found for GSTP1 105IleVal and CYP2E1 -71TT.	Folic Acid	91-94	glutathione S-transferase pi 1	Homo sapiens	125-130
18028541-4	2007	Defective function of the Folr1 (also known as Folbp1; homologue of human FRalpha) gene in mice results in inadequate transport, accumulation, or metabolism of folate during cardiovascular morphogenesis.	Folic Acid	160-166	folate receptor alpha	Homo sapiens	26-31
18028541-4	2007	Defective function of the Folr1 (also known as Folbp1; homologue of human FRalpha) gene in mice results in inadequate transport, accumulation, or metabolism of folate during cardiovascular morphogenesis.	Folic Acid	160-166	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	74-81
18025275-1	2007	Folylpolyglutamyl synthase (FPGS) converts intracellular folates and antifolates to polyglutamates.	Folic Acid	57-64	folylpolyglutamate synthase	Homo sapiens	0-26
18025275-1	2007	Folylpolyglutamyl synthase (FPGS) converts intracellular folates and antifolates to polyglutamates.	Folic Acid	57-64	folylpolyglutamate synthase	Homo sapiens	28-32
18025275-3	2007	FPGS modulation affects the chemosensitivity of cancer cells to antifolates, such as methotrexate, and 5-fluorouracil (5FU) by altering polyglutamylation of antifolates and specific target intracellular folate cofactors.	Folic Acid	68-74	folylpolyglutamate synthase	Homo sapiens	0-4
18025275-4	2007	However, this effect may be counterbalanced by FPGS modulation-induced changes in polyglutamylation of other intracellular folate cofactors and total intracellular folate pools.	Folic Acid	123-129	folylpolyglutamate synthase	Homo sapiens	47-51
18025275-4	2007	However, this effect may be counterbalanced by FPGS modulation-induced changes in polyglutamylation of other intracellular folate cofactors and total intracellular folate pools.	Folic Acid	164-170	folylpolyglutamate synthase	Homo sapiens	47-51
17896913-6	2007	Nonclassical antifolates for antitumor and parasitic chemotherapy, such as nolatrexed (8), trimethoprim {TMP, (11)} and piritrexim {PTX, (12)}, can passively diffuse into cells and hence do not have to depend on FPGS or the reduced folate carrier (RFC).	Folic Acid	17-23	folylpolyglutamate synthase	Homo sapiens	212-216
17320366-9	2007	The response of the DKK1 and TAGLN gene promoters to folate deficiency and compounds was examined in NIH3T3 cells using luciferase reporter plasmids.	Folic Acid	53-59	transgelin	Mus musculus	29-34
17420066-1	2007	Suboptimal DNA repair capacity is a risk factor for cancer that may be modulated by dietary nutrient intake, and serine hydroxymethyltransferase (SHMT) participates in folate metabolism and synthesis of purines and pyrimidines needed for DNA repair.	Folic Acid	168-174	serine hydroxymethyltransferase 1	Homo sapiens	146-150
17597297-0	2007	Preliminary evidence for involvement of the folate gene polymorphism 19bp deletion-DHFR in occurrence of autism.	Folic Acid	44-50	dihydrofolate reductase	Homo sapiens	83-87
17597297-5	2007	Here, we report that the 19bp-deletion polymorphism of DHFR acts independently (OR 2.69, 95% CI; 1.00-7.28, p<0.05) and in concert with related folate polymorphisms as a significant risk factor for autism.	Folic Acid	144-150	dihydrofolate reductase	Homo sapiens	55-59
17616776-10	2007	CONCLUSIONS: Long-term oversupplementation with folate leads to a specific and significant down-regulation in intestinal and renal folate uptake, which is associated with a decrease in message levels of hRFC, PCFT/HCP1, and FR.	Folic Acid	48-54	solute carrier family 46 member 1	Homo sapiens	209-218
17486595-2	2007	This has focused attention on folate-related genes such as dihydrofolate reductase (DHFR) in a bid to identify the genetic factors that influence NTD risk through either the fetal or maternal genotype.	Folic Acid	30-36	dihydrofolate reductase	Homo sapiens	59-82
17486595-2	2007	This has focused attention on folate-related genes such as dihydrofolate reductase (DHFR) in a bid to identify the genetic factors that influence NTD risk through either the fetal or maternal genotype.	Folic Acid	30-36	dihydrofolate reductase	Homo sapiens	84-88
17482557-1	2007	Folate-activated one-carbon units are derived from serine through the activity of the pyridoxal-phosphate (PLP)-dependent isozymes of serine hydroxymethyltransferase (SHMT).	Folic Acid	0-6	serine hydroxymethyltransferase 1	Homo sapiens	134-165
17482557-1	2007	Folate-activated one-carbon units are derived from serine through the activity of the pyridoxal-phosphate (PLP)-dependent isozymes of serine hydroxymethyltransferase (SHMT).	Folic Acid	0-6	serine hydroxymethyltransferase 1	Homo sapiens	167-171
17384003-0	2007	Folate and methylation status in relation to phosphorylated tau protein(181P) and beta-amyloid(1-42) in cerebrospinal fluid.	Folic Acid	0-6	microtubule associated protein tau	Homo sapiens	60-63
17400285-1	2007	PURPOSE: Folate receptor alpha (FOLR1) is a membrane bound receptor involved in the transport of folate as well as other regulatory cellular processes.	Folic Acid	97-103	folate receptor alpha	Homo sapiens	9-30
17400285-1	2007	PURPOSE: Folate receptor alpha (FOLR1) is a membrane bound receptor involved in the transport of folate as well as other regulatory cellular processes.	Folic Acid	97-103	folate receptor alpha	Homo sapiens	32-37
17188299-0	2007	Cryptochrome 3 from Arabidopsis thaliana: structural and functional analysis of its complex with a folate light antenna.	Folic Acid	99-105	cryptochrome 3	Arabidopsis thaliana	0-14
17250800-3	2007	Folate analogs that cannot undergo the rate-limiting step in catalysis were inhibitors of murine MTHFS.	Folic Acid	0-6	5, 10-methenyltetrahydrofolate synthetase	Mus musculus	97-102
16950800-7	2007	We observed an interaction between the C677T polymorphism and total folate intake on SCC risk (P, interaction=0.04); the highest risk was observed among women with TT genotype and low folate intake (OR=2.14; 95% CI=1.01-4.50).	Folic Acid	68-74	serpin family B member 3	Homo sapiens	85-88
16950800-7	2007	We observed an interaction between the C677T polymorphism and total folate intake on SCC risk (P, interaction=0.04); the highest risk was observed among women with TT genotype and low folate intake (OR=2.14; 95% CI=1.01-4.50).	Folic Acid	184-190	serpin family B member 3	Homo sapiens	85-88
16950800-10	2007	This study suggests a possible role of the polymorphisms in MTHFR and VDR interacting with dietary intakes of folate and vitamin D in skin cancer development, especially for SCC.	Folic Acid	110-116	serpin family B member 3	Homo sapiens	174-177
17439323-0	2007	Associations of common polymorphisms in the thymidylate synthase, reduced folate carrier and 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase genes with folate and homocysteine levels and venous thrombosis risk.	Folic Acid	202-208	thymidylate synthetase	Homo sapiens	44-64
17439323-7	2007	However, the TYMS 28-bp repeat was associated with serum and RBC folate levels.	Folic Acid	65-71	thymidylate synthetase	Homo sapiens	13-17
18160775-0	2007	The molecular basis of the folate-sensitive fragile site FRA11A at 11q13.	Folic Acid	27-33	fragile site, folic acid type, rare, fra(11)(q13.3)	Homo sapiens	57-63
18160775-1	2007	We report on the molecular basis of the rare, folate-sensitive fragile site FRA11A in chromosome band 11q13 in a family with cytogenetic expression.	Folic Acid	46-52	fragile site, folic acid type, rare, fra(11)(q13.3)	Homo sapiens	76-82
17684410-3	2007	We found that functional polymorphisms in methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS), two key enzymes involved in folate and methyl group metabolism, were significantly associated with increased risk of esophageal squamous cell carcinoma, gastric cardia carcinoma, and pancreatic carcinoma.	Folic Acid	61-67	thymidylate synthetase	Homo sapiens	90-110
17684410-3	2007	We found that functional polymorphisms in methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS), two key enzymes involved in folate and methyl group metabolism, were significantly associated with increased risk of esophageal squamous cell carcinoma, gastric cardia carcinoma, and pancreatic carcinoma.	Folic Acid	61-67	thymidylate synthetase	Homo sapiens	112-114
16835399-0	2006	Folate status modulates the induction of hepatic glycine N-methyltransferase and homocysteine metabolism in diabetic rats.	Folic Acid	0-6	glycine N-methyltransferase	Rattus norvegicus	49-76
16835399-1	2006	A diabetic state induces the activity and abundance of glycine N-methyltransferase (GNMT), a key protein in the regulation of folate, methyl group, and homocysteine metabolism.	Folic Acid	126-132	glycine N-methyltransferase	Rattus norvegicus	55-82
16835399-1	2006	A diabetic state induces the activity and abundance of glycine N-methyltransferase (GNMT), a key protein in the regulation of folate, methyl group, and homocysteine metabolism.	Folic Acid	126-132	glycine N-methyltransferase	Rattus norvegicus	84-88
16835399-2	2006	Because the folate-dependent one-carbon pool is a source of methyl groups and 5-methyltetrahydrofolate allosterically inhibits GNMT, the aim of this study was to determine whether folate status has an impact on the interaction between diabetes and methyl group metabolism.	Folic Acid	96-102	glycine N-methyltransferase	Rattus norvegicus	127-131
16835399-4	2006	The activities of GNMT, phosphatidylethanolamine N-methyltransferase (PEMT), and betaine-homocysteine S-methyltransferase (BHMT) were increased about twofold in diabetic rat liver; folate deficiency resulted in the greatest elevation in GNMT activity.	Folic Acid	181-187	glycine N-methyltransferase	Rattus norvegicus	18-22
16859665-1	2006	Gamma-glutamyl hydrolase (GGH) is a lysosomal enzyme involved in the metabolism of folates and anti-folates.	Folic Acid	83-90	gamma-glutamyl hydrolase	Homo sapiens	0-24
16859665-1	2006	Gamma-glutamyl hydrolase (GGH) is a lysosomal enzyme involved in the metabolism of folates and anti-folates.	Folic Acid	83-90	gamma-glutamyl hydrolase	Homo sapiens	26-29
16859665-1	2006	Gamma-glutamyl hydrolase (GGH) is a lysosomal enzyme involved in the metabolism of folates and anti-folates.	Folic Acid	100-107	gamma-glutamyl hydrolase	Homo sapiens	0-24
16859665-1	2006	Gamma-glutamyl hydrolase (GGH) is a lysosomal enzyme involved in the metabolism of folates and anti-folates.	Folic Acid	100-107	gamma-glutamyl hydrolase	Homo sapiens	26-29
16859665-4	2006	Thus, GGH plays an important role in the cellular homeostasis of folate.	Folic Acid	65-71	gamma-glutamyl hydrolase	Homo sapiens	6-9
17074544-4	2006	In black women, there appeared to be an interaction between dietary folate intake and the SHMT1(1420)T variant allele, such that only carriers who also were in the lowest quartile of dietary folate intake had higher risk of spontaneous preterm birth (OR = 2.6, 95% CI 0.8-8.0) and SGA (OR = 2.9, 95% CI 0.9-8.9).	Folic Acid	68-74	serine hydroxymethyltransferase 1	Homo sapiens	90-95
17074544-4	2006	In black women, there appeared to be an interaction between dietary folate intake and the SHMT1(1420)T variant allele, such that only carriers who also were in the lowest quartile of dietary folate intake had higher risk of spontaneous preterm birth (OR = 2.6, 95% CI 0.8-8.0) and SGA (OR = 2.9, 95% CI 0.9-8.9).	Folic Acid	191-197	serine hydroxymethyltransferase 1	Homo sapiens	90-95
17201138-1	2006	BACKGROUND: 5,10-Methylenetetrahydrofolate reductase (MTHFR), a key enzyme in folate metabolism, plays a major role in the provision of methyl groups for DNA methylation; thymidylate synthase (TS) is a rate-limiting enzyme in the synthesis of dTMP and DNA repair.	Folic Acid	36-42	thymidylate synthetase	Homo sapiens	171-191
17006651-5	2006	Part of the N-glycans could be released with peptide-(N (4)-(N-acetyl-beta -glucosaminyl)asparagine amidase F (PNGase F-sensitive N-glycans); the PNGase F-resistant N-glycans were PNGase A-sensitive.	Folic Acid	53-60	N-glycanase 1	Homo sapiens	111-117
17006651-5	2006	Part of the N-glycans could be released with peptide-(N (4)-(N-acetyl-beta -glucosaminyl)asparagine amidase F (PNGase F-sensitive N-glycans); the PNGase F-resistant N-glycans were PNGase A-sensitive.	Folic Acid	53-60	N-glycanase 1	Homo sapiens	146-152
17006651-5	2006	Part of the N-glycans could be released with peptide-(N (4)-(N-acetyl-beta -glucosaminyl)asparagine amidase F (PNGase F-sensitive N-glycans); the PNGase F-resistant N-glycans were PNGase A-sensitive.	Folic Acid	53-60	N-glycanase 1	Homo sapiens	146-152
16826517-1	2006	Gamma-glutamyl hydrolase (GGH) catalyzes degradation of the active polyglutamates of natural folates and the antifolate methotrexate (MTX).	Folic Acid	93-100	gamma-glutamyl hydrolase	Homo sapiens	0-24
16826517-1	2006	Gamma-glutamyl hydrolase (GGH) catalyzes degradation of the active polyglutamates of natural folates and the antifolate methotrexate (MTX).	Folic Acid	93-100	gamma-glutamyl hydrolase	Homo sapiens	26-29
16491109-8	2006	RESULTS: Subjects receiving folic acid supplementation showed a decrement of homocysteine and an amelioration of insulin sensitivity; this treatment was also associated with a significant drop in the circulating concentration of monocyte chemoattractant protein-1, interleukin-8 and C-reactive protein, in the absence of any significant variation of BMI or fat mass.	Folic Acid	28-38	C-C motif chemokine ligand 2	Homo sapiens	229-263
16917148-2	2006	We demonstrate herein that dietary deprivation of folate and vitamin E, coupled with iron as a pro-oxidant, fosters an increase in nonphospho- and-phospho-tau within brain tissue of mice homozygously lacking apolipoprotein E as assayed by monoclonal antibodies Tau-1 and PHF-1, respectively.	Folic Acid	50-56	PHD finger protein 1	Mus musculus	271-276
16841906-3	2006	Binding of FBP to the sensor surface could be blocked at concentrations as high as 1 microM with a 100-fold excess of folic acid, indicating the specificity of the folate-FBP interaction and the absence of nonspecific binding to the functionalized surface.	Folic Acid	118-128	folate receptor alpha	Homo sapiens	11-14
16841906-3	2006	Binding of FBP to the sensor surface could be blocked at concentrations as high as 1 microM with a 100-fold excess of folic acid, indicating the specificity of the folate-FBP interaction and the absence of nonspecific binding to the functionalized surface.	Folic Acid	164-170	folate receptor alpha	Homo sapiens	11-14
16841906-3	2006	Binding of FBP to the sensor surface could be blocked at concentrations as high as 1 microM with a 100-fold excess of folic acid, indicating the specificity of the folate-FBP interaction and the absence of nonspecific binding to the functionalized surface.	Folic Acid	164-170	folate receptor alpha	Homo sapiens	171-174
16723031-3	2006	Thymidylate synthase (TYMS) is a key enzyme that participates in folate metabolism and catalyzes the conversion of dUMP to dTMP in the process of DNA synthesis.	Folic Acid	65-71	thymidylate synthetase	Homo sapiens	0-20
16723031-3	2006	Thymidylate synthase (TYMS) is a key enzyme that participates in folate metabolism and catalyzes the conversion of dUMP to dTMP in the process of DNA synthesis.	Folic Acid	65-71	thymidylate synthetase	Homo sapiens	22-26
16611376-5	2006	In addition, folate deficiency was also found to downregulate IL-2, Fas antigen and bcl-2 expression, in terms of either mRNA or protein levels.	Folic Acid	13-19	Fas cell surface death receptor	Homo sapiens	68-79
16611376-6	2006	The downregulation of Fas antigen suggests that folate deficiency-induced apoptosis probably does not occur via the Fas pathway.	Folic Acid	48-54	Fas cell surface death receptor	Homo sapiens	22-33
16632891-5	2006	The activity of hepatic glycine N-methyltransferase (GNMT), an enzyme involved in the regulation of tissue S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH), was increased by folate deficiency (p &lt; 0.006) and decreased by selenium deprivation (p &lt; 0.0003).	Folic Acid	185-191	glycine N-methyltransferase	Rattus norvegicus	24-51
16632891-5	2006	The activity of hepatic glycine N-methyltransferase (GNMT), an enzyme involved in the regulation of tissue S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH), was increased by folate deficiency (p &lt; 0.006) and decreased by selenium deprivation (p &lt; 0.0003).	Folic Acid	185-191	glycine N-methyltransferase	Rattus norvegicus	53-57
16470783-4	2006	Prior complexation of FBP with folate abolished heparin binding, and thus folate competes with heparin for binding to FBP.	Folic Acid	31-37	folate receptor alpha	Bos taurus	22-25
16470783-4	2006	Prior complexation of FBP with folate abolished heparin binding, and thus folate competes with heparin for binding to FBP.	Folic Acid	31-37	folate receptor alpha	Bos taurus	118-121
16470783-4	2006	Prior complexation of FBP with folate abolished heparin binding, and thus folate competes with heparin for binding to FBP.	Folic Acid	74-80	folate receptor alpha	Bos taurus	22-25
16470783-4	2006	Prior complexation of FBP with folate abolished heparin binding, and thus folate competes with heparin for binding to FBP.	Folic Acid	74-80	folate receptor alpha	Bos taurus	118-121
16470783-6	2006	In contrast to the mobility shifts induced by heparin, free and folate-bound FBP were not separated by CE.	Folic Acid	64-70	folate receptor alpha	Bos taurus	77-80
16470783-7	2006	However, binding of folate induced a distinct increase in FBP-peak symmetry, and using heparin as an affinity displacer, the free FBP in equilibrium with folate-FBP complexes could readily be separated from the complexes.	Folic Acid	20-26	folate receptor alpha	Bos taurus	58-61
16470783-7	2006	However, binding of folate induced a distinct increase in FBP-peak symmetry, and using heparin as an affinity displacer, the free FBP in equilibrium with folate-FBP complexes could readily be separated from the complexes.	Folic Acid	20-26	folate receptor alpha	Bos taurus	130-133
16112698-9	2006	Folic acid also reduced VPA-induced alterations in p53, NF-kappaB, Pim-1, c-Myb, and Bax/Bcl-2 protein levels, while pantothenic acid prevented VPA-induced alterations in NF-kappaB, Pim-1, and c-Myb.	Folic Acid	0-10	transformation related protein 53, pseudogene	Mus musculus	51-54
16112698-9	2006	Folic acid also reduced VPA-induced alterations in p53, NF-kappaB, Pim-1, c-Myb, and Bax/Bcl-2 protein levels, while pantothenic acid prevented VPA-induced alterations in NF-kappaB, Pim-1, and c-Myb.	Folic Acid	0-10	proviral integration site 1	Mus musculus	67-72
16112698-9	2006	Folic acid also reduced VPA-induced alterations in p53, NF-kappaB, Pim-1, c-Myb, and Bax/Bcl-2 protein levels, while pantothenic acid prevented VPA-induced alterations in NF-kappaB, Pim-1, and c-Myb.	Folic Acid	0-10	myeloblastosis oncogene	Mus musculus	74-79
16112698-9	2006	Folic acid also reduced VPA-induced alterations in p53, NF-kappaB, Pim-1, c-Myb, and Bax/Bcl-2 protein levels, while pantothenic acid prevented VPA-induced alterations in NF-kappaB, Pim-1, and c-Myb.	Folic Acid	0-10	proviral integration site 1	Mus musculus	182-187
16112698-9	2006	Folic acid also reduced VPA-induced alterations in p53, NF-kappaB, Pim-1, c-Myb, and Bax/Bcl-2 protein levels, while pantothenic acid prevented VPA-induced alterations in NF-kappaB, Pim-1, and c-Myb.	Folic Acid	0-10	myeloblastosis oncogene	Mus musculus	193-198
16910166-6	2006	By contrast, expression and activity of methionine synthase decreased following folate deprivation in the order ApoE +/+ &lt; ApoE +/- &lt; ApoE -/-.	Folic Acid	80-86	5-methyltetrahydrofolate-homocysteine methyltransferase	Mus musculus	40-59
16169100-2	2005	Localization of mFPGS within mitochondria may help elucidate how the enzyme functions to maintain the mitochondrial folate pool.	Folic Acid	116-122	folylpolyglutamyl synthetase	Mus musculus	16-21
16128986-9	2005	FBP could have a bacteriostatic function by depriving folate-requiring bacteria of folate and/or ascertain a normal DNA replication subsequent to fertilization by vectorial transfer of folate to the inner compartment of the spermatozoa.	Folic Acid	54-60	folate receptor alpha	Homo sapiens	0-3
16128986-9	2005	FBP could have a bacteriostatic function by depriving folate-requiring bacteria of folate and/or ascertain a normal DNA replication subsequent to fertilization by vectorial transfer of folate to the inner compartment of the spermatozoa.	Folic Acid	83-89	folate receptor alpha	Homo sapiens	0-3
16128986-9	2005	FBP could have a bacteriostatic function by depriving folate-requiring bacteria of folate and/or ascertain a normal DNA replication subsequent to fertilization by vectorial transfer of folate to the inner compartment of the spermatozoa.	Folic Acid	83-89	folate receptor alpha	Homo sapiens	0-3
16207145-1	2005	Folate metabolism is the target of two major drug groups: folate antagonists (for example, methotrexate) and thymidylate synthase inhibitors (for example, 5-fluorouracil).	Folic Acid	0-6	thymidylate synthetase	Homo sapiens	109-129
16172227-1	2005	Folate receptor alpha (FRalpha) expression in epithelial ovarian cancer may be related to folate intake.	Folic Acid	90-96	folate receptor alpha	Homo sapiens	0-21
16172227-1	2005	Folate receptor alpha (FRalpha) expression in epithelial ovarian cancer may be related to folate intake.	Folic Acid	90-96	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	23-30
16266457-10	2005	(3) The addition of folic acid reduced PAI-1 but increased tPA at both mRNA and protein levels, which were both obvious at concentrations of 500 micromol/L Hcy, compared with only Hcy group (P &lt; 0.05).	Folic Acid	20-30	serpin family E member 1	Homo sapiens	39-44
15959877-2	2005	N-acetyltransferase 1 is involved in acetylation of aromatic and heterocyclic amines and the catabolism of folates.	Folic Acid	107-114	N-acetyltransferase 1	Homo sapiens	0-21
15969536-2	2005	The interactions between bovine folate-binding protein (FBP) and different folate derivatives in pure diastereoisomeric forms were studied at pH 7.4 by a surface plasmon resonance technology (Biacore).	Folic Acid	32-38	folate receptor alpha	Bos taurus	56-59
15969536-4	2005	The equilibrium dissociation constant (K(D)), calculated from the quotient of k(d)/k(a), showed that the two forms of folates not occurring in nature, that is, folic acid and (6R)-5-CH(3)-5,6,7,8-tetrahydrofolic acid, had the highest affinities for FBP, 20 and 160 pmol/L, respectively.	Folic Acid	118-125	folate receptor alpha	Bos taurus	249-252
15781839-1	2005	The authors describe a 6-year-old girl with developmental delay, psychomotor regression, seizures, mental retardation, and autistic features associated with low CSF levels of 5-methyltetrahydrofolate, the biologically active form of folates in CSF and blood.	Folic Acid	233-240	colony stimulating factor 2	Homo sapiens	161-164
15579479-2	2005	Thymidylate synthase (TYMS) is involved in the metabolism of folate and the provision of nucleotides needed for DNA synthesis and repair.	Folic Acid	61-67	thymidylate synthetase	Homo sapiens	0-20
15579479-2	2005	Thymidylate synthase (TYMS) is involved in the metabolism of folate and the provision of nucleotides needed for DNA synthesis and repair.	Folic Acid	61-67	thymidylate synthetase	Homo sapiens	22-26
15703271-0	2005	Renal tubular reabsorption of folate mediated by folate binding protein 1.	Folic Acid	30-36	folate receptor 1 (adult)	Mus musculus	49-73
15703271-4	2005	With the use of targeted inactivation of the folate binding protein 1 (folbp1) and folate binding protein 2 (folbp2) genes in mice, the role of folate receptors in renal epithelial folate reabsorption was evaluated during low and normal folate intake.	Folic Acid	45-51	folate receptor 1 (adult)	Mus musculus	71-77
15703271-5	2005	Inactivation of folbp1 was associated with (1) loss of (3)H-folic acid binding to crude kidney membranes, (2) increase in renal folate clearance, and (3) increase in urinary excretion and decrease in renal uptake of injected (3)H-methyltetrahydrofolate.	Folic Acid	128-134	folate receptor 1 (adult)	Mus musculus	16-22
15703271-7	2005	Thus, folbp1 is essential for normal renal tubular folate reabsorption, preventing excessive urinary folate loss.	Folic Acid	51-57	folate receptor 1 (adult)	Mus musculus	6-12
15703271-7	2005	Thus, folbp1 is essential for normal renal tubular folate reabsorption, preventing excessive urinary folate loss.	Folic Acid	101-107	folate receptor 1 (adult)	Mus musculus	6-12
15703271-8	2005	Folbp1 is heavily expressed in choroid plexus, yolk sac, and placenta, supporting a role of folbp1 in folate transport in other tissues.	Folic Acid	102-108	folate receptor 1 (adult)	Mus musculus	0-6
15705887-2	2005	We therefore investigated the effect of targeted ablation of two folate transport genes, folate binding protein 1 (Folbp1) and reduced folate carrier 1 (RFC1), on folate homeostasis to elucidate the molecular mechanisms of folate action on colonocyte cell proliferation, gene expression, and colon carcinogenesis.	Folic Acid	65-71	folate receptor 1 (adult)	Mus musculus	89-113
15705887-2	2005	We therefore investigated the effect of targeted ablation of two folate transport genes, folate binding protein 1 (Folbp1) and reduced folate carrier 1 (RFC1), on folate homeostasis to elucidate the molecular mechanisms of folate action on colonocyte cell proliferation, gene expression, and colon carcinogenesis.	Folic Acid	65-71	folate receptor 1 (adult)	Mus musculus	115-121
15705887-2	2005	We therefore investigated the effect of targeted ablation of two folate transport genes, folate binding protein 1 (Folbp1) and reduced folate carrier 1 (RFC1), on folate homeostasis to elucidate the molecular mechanisms of folate action on colonocyte cell proliferation, gene expression, and colon carcinogenesis.	Folic Acid	89-95	folate receptor 1 (adult)	Mus musculus	115-121
15705887-3	2005	Targeted deletion of Folbp1 (Folbp1(+/-) and Folbp1(-/-)) significantly reduced (P &lt; 0.05) colonic Folbp1 mRNA, colonic mucosa, and plasma folate concentration.	Folic Acid	142-148	folate receptor 1 (adult)	Mus musculus	21-27
15705887-3	2005	Targeted deletion of Folbp1 (Folbp1(+/-) and Folbp1(-/-)) significantly reduced (P &lt; 0.05) colonic Folbp1 mRNA, colonic mucosa, and plasma folate concentration.	Folic Acid	142-148	folate receptor 1 (adult)	Mus musculus	45-56
15705887-13	2005	In conclusion, Folbp1 and RFC1 genetically modified mice exhibit distinct changes in colonocyte phenotype and therefore have utility as models to examine the role of folate homeostasis in colon cancer development.	Folic Acid	166-172	folate receptor 1 (adult)	Mus musculus	15-21
15494396-10	2005	Sequence analysis of the FSH3p indicated that this protein may be involved in folate metabolism either by carrying serine hydrolase activity required for the novel metabolic pathway involving dihydrofolate reductase (DHFR) or by directly interacting with the DHFR enzyme.	Folic Acid	78-84	putative serine hydrolase	Saccharomyces cerevisiae S288C	25-30
15494396-10	2005	Sequence analysis of the FSH3p indicated that this protein may be involved in folate metabolism either by carrying serine hydrolase activity required for the novel metabolic pathway involving dihydrofolate reductase (DHFR) or by directly interacting with the DHFR enzyme.	Folic Acid	78-84	dihydrofolate reductase	Saccharomyces cerevisiae S288C	192-215
15494396-10	2005	Sequence analysis of the FSH3p indicated that this protein may be involved in folate metabolism either by carrying serine hydrolase activity required for the novel metabolic pathway involving dihydrofolate reductase (DHFR) or by directly interacting with the DHFR enzyme.	Folic Acid	78-84	dihydrofolate reductase	Saccharomyces cerevisiae S288C	217-221
15494396-10	2005	Sequence analysis of the FSH3p indicated that this protein may be involved in folate metabolism either by carrying serine hydrolase activity required for the novel metabolic pathway involving dihydrofolate reductase (DHFR) or by directly interacting with the DHFR enzyme.	Folic Acid	78-84	dihydrofolate reductase	Saccharomyces cerevisiae S288C	259-263
15630450-5	2005	We found significantly lower expression of the reduced folate carrier (SLC19A1, an MTX uptake transporter) in E2A-PBX1 ALL, significantly higher expression of breast cancer resistance protein (ABCG2, an MTX efflux transporter) in TEL-AML1 ALL, and lower expression of FPGS (which catalyzes formation of MTXPG) in T-lineage ALL, consistent with lower MTXPG accumulation in these ALL subtypes.	Folic Acid	55-61	PBX homeobox 1	Homo sapiens	114-118
15609999-5	2004	Spectra were recorded for binary and ternary complexes of wild-type DHFR bound to the substrate dihydrofolate (DHF), the product tetrahydrofolate (THF), the pseudosubstrate folate, reduced and oxidized NADPH cofactor, and the inactive cofactor analogue 5,6-dihydroNADPH.	Folic Acid	103-109	Dihydrofolate reductase	Escherichia coli	68-72
15585623-2	2004	We hypothesized that polymorphisms of the thymidylate synthase (TYMS) gene, which regulates a key enzyme in folate metabolism required for DNA synthesis and repair, are associated with SCCHN risk.	Folic Acid	108-114	thymidylate synthetase	Homo sapiens	42-62
15585623-2	2004	We hypothesized that polymorphisms of the thymidylate synthase (TYMS) gene, which regulates a key enzyme in folate metabolism required for DNA synthesis and repair, are associated with SCCHN risk.	Folic Acid	108-114	thymidylate synthetase	Homo sapiens	64-68
15542523-1	2004	BACKGROUND: Folylpoly-gamma-glutamate synthetase (FPGS) converts intracellular folates and antifolates (for example, methotrexate (MTX)) to polyglutamates.	Folic Acid	79-86	folylpolyglutamate synthase	Homo sapiens	12-48
15542523-1	2004	BACKGROUND: Folylpoly-gamma-glutamate synthetase (FPGS) converts intracellular folates and antifolates (for example, methotrexate (MTX)) to polyglutamates.	Folic Acid	79-86	folylpolyglutamate synthase	Homo sapiens	50-54
15542523-7	2004	RESULTS: Compared with cells expressing endogenous FPGS, those overexpressing FPGS had significantly faster growth rates and higher concentrations of total folate and long chain folate polyglutamates while antisense FPGS inhibition produced opposite results.	Folic Acid	156-162	folylpolyglutamate synthase	Homo sapiens	78-82
15542523-7	2004	RESULTS: Compared with cells expressing endogenous FPGS, those overexpressing FPGS had significantly faster growth rates and higher concentrations of total folate and long chain folate polyglutamates while antisense FPGS inhibition produced opposite results.	Folic Acid	156-162	folylpolyglutamate synthase	Homo sapiens	78-82
15542523-10	2004	CONCLUSIONS: These data provide functional evidence that FPGS overexpression and inhibition modulate chemosensitivity of colon cancer cells to 5-FU by altering intracellular folate polyglutamylation, providing proof of principle.	Folic Acid	174-180	folylpolyglutamate synthase	Homo sapiens	57-61
15382038-2	2004	Cobalamin-dependent methionine synthase (MS) catalyses the formation of methionine and tetrahydrofolate from homocysteine and methyltetrahydrofolate, thus linking the methionine and folate pathways.	Folic Acid	97-103	5-methyltetrahydrofolate-homocysteine methyltransferase	Mus musculus	20-39
15382038-2	2004	Cobalamin-dependent methionine synthase (MS) catalyses the formation of methionine and tetrahydrofolate from homocysteine and methyltetrahydrofolate, thus linking the methionine and folate pathways.	Folic Acid	97-103	5-methyltetrahydrofolate-homocysteine methyltransferase	Mus musculus	41-43
15504856-1	2004	Most drugs used for prevention and treatment of Pneumocystis jirovecii pneumonia target enzymes involved in the biosynthesis of folic acid, i.e., dihydropteroate synthase (DHPS) and dihydrofolate reductase (DHFR).	Folic Acid	128-138	dihydrofolate reductase	Homo sapiens	207-211
15259034-2	2004	Folic acid-binding protein one (Folbp1) is the primary mediator of folic acid transport into murine cells.	Folic Acid	0-10	folate receptor 1 (adult)	Mus musculus	32-38
15259034-2	2004	Folic acid-binding protein one (Folbp1) is the primary mediator of folic acid transport into murine cells.	Folic Acid	67-77	folate receptor 1 (adult)	Mus musculus	32-38
15259034-5	2004	In this study, we examined the role of folic acid on the phenotypic expression of heart defects in Folbp1 mice, mindful of the importance of neural crest cells to the formation of the conotruncus.	Folic Acid	39-49	folate receptor 1 (adult)	Mus musculus	99-105
15135403-3	2004	The enzyme 5,10-methenyltetrahydrofolate synthetase (MTHFS, EC 6.3.3.2) catalyzes the ATP-dependent conversion of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate, and has been shown to affect intracellular folate concentrations by accelerating folate degradation.	Folic Acid	34-40	5, 10-methenyltetrahydrofolate synthetase	Mus musculus	53-58
15135403-3	2004	The enzyme 5,10-methenyltetrahydrofolate synthetase (MTHFS, EC 6.3.3.2) catalyzes the ATP-dependent conversion of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate, and has been shown to affect intracellular folate concentrations by accelerating folate degradation.	Folic Acid	132-138	5, 10-methenyltetrahydrofolate synthetase	Mus musculus	11-51
15135403-3	2004	The enzyme 5,10-methenyltetrahydrofolate synthetase (MTHFS, EC 6.3.3.2) catalyzes the ATP-dependent conversion of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate, and has been shown to affect intracellular folate concentrations by accelerating folate degradation.	Folic Acid	132-138	5, 10-methenyltetrahydrofolate synthetase	Mus musculus	53-58
15094208-1	2004	Folate receptor alpha (FRalpha), a glycosyl phosphatidylinositol linked protein with a great affinity for folic acid and some reduced folates such as 5-methyltetrahydrofolate and tetrahydrofolate is present on a limited number of epithelial cells, especially the kidney, placenta and choroid plexus.	Folic Acid	106-116	folate receptor alpha	Homo sapiens	0-21
15094208-1	2004	Folate receptor alpha (FRalpha), a glycosyl phosphatidylinositol linked protein with a great affinity for folic acid and some reduced folates such as 5-methyltetrahydrofolate and tetrahydrofolate is present on a limited number of epithelial cells, especially the kidney, placenta and choroid plexus.	Folic Acid	106-116	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	23-30
15094208-1	2004	Folate receptor alpha (FRalpha), a glycosyl phosphatidylinositol linked protein with a great affinity for folic acid and some reduced folates such as 5-methyltetrahydrofolate and tetrahydrofolate is present on a limited number of epithelial cells, especially the kidney, placenta and choroid plexus.	Folic Acid	134-141	folate receptor alpha	Homo sapiens	0-21
15094208-1	2004	Folate receptor alpha (FRalpha), a glycosyl phosphatidylinositol linked protein with a great affinity for folic acid and some reduced folates such as 5-methyltetrahydrofolate and tetrahydrofolate is present on a limited number of epithelial cells, especially the kidney, placenta and choroid plexus.	Folic Acid	134-141	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	23-30
14676127-2	2003	EXPERIMENTAL DESIGN: Real-time PCR was used to quantify expression levels of folate-associated genes including the reduced folate carrier (RFC-1), folylpolyglutamate synthase (FPGS), gamma-glutamyl hydrolase (GGH),and thymidylate synthase (TS) in tumor tissue and adjacent mucosa of patients with primary colorectal cancer (n=102).	Folic Acid	77-83	folylpolyglutamate synthase	Homo sapiens	147-174
14676127-2	2003	EXPERIMENTAL DESIGN: Real-time PCR was used to quantify expression levels of folate-associated genes including the reduced folate carrier (RFC-1), folylpolyglutamate synthase (FPGS), gamma-glutamyl hydrolase (GGH),and thymidylate synthase (TS) in tumor tissue and adjacent mucosa of patients with primary colorectal cancer (n=102).	Folic Acid	77-83	folylpolyglutamate synthase	Homo sapiens	176-180
14676127-2	2003	EXPERIMENTAL DESIGN: Real-time PCR was used to quantify expression levels of folate-associated genes including the reduced folate carrier (RFC-1), folylpolyglutamate synthase (FPGS), gamma-glutamyl hydrolase (GGH),and thymidylate synthase (TS) in tumor tissue and adjacent mucosa of patients with primary colorectal cancer (n=102).	Folic Acid	77-83	gamma-glutamyl hydrolase	Homo sapiens	183-207
14676127-2	2003	EXPERIMENTAL DESIGN: Real-time PCR was used to quantify expression levels of folate-associated genes including the reduced folate carrier (RFC-1), folylpolyglutamate synthase (FPGS), gamma-glutamyl hydrolase (GGH),and thymidylate synthase (TS) in tumor tissue and adjacent mucosa of patients with primary colorectal cancer (n=102).	Folic Acid	77-83	gamma-glutamyl hydrolase	Homo sapiens	209-212
14676127-2	2003	EXPERIMENTAL DESIGN: Real-time PCR was used to quantify expression levels of folate-associated genes including the reduced folate carrier (RFC-1), folylpolyglutamate synthase (FPGS), gamma-glutamyl hydrolase (GGH),and thymidylate synthase (TS) in tumor tissue and adjacent mucosa of patients with primary colorectal cancer (n=102).	Folic Acid	77-83	thymidylate synthetase	Homo sapiens	218-238
14676127-6	2003	Patients with high FPGS levels (&gt;0.92) in mucosa also showed significantly higher total folate concentrations (P=0.03) and gene expression levels of RFC-1 (P&lt;0.01), GGH (P&lt;0.01), and TS (P=0.04) compared with patients with low FPGS levels.	Folic Acid	91-97	folylpolyglutamate synthase	Homo sapiens	19-23
14676127-7	2003	The total reduced folate concentration correlated with the gene expression levels of RFC-1 and FPGS but not with TS or GGH.	Folic Acid	18-24	folylpolyglutamate synthase	Homo sapiens	95-99
14597182-1	2003	gamma-Glutamyl hydrolase (GGH) plays a central role in folate metabolism and antifolate action.	Folic Acid	55-61	gamma-glutamyl hydrolase	Homo sapiens	0-24
14597182-1	2003	gamma-Glutamyl hydrolase (GGH) plays a central role in folate metabolism and antifolate action.	Folic Acid	55-61	gamma-glutamyl hydrolase	Homo sapiens	26-29
14599874-6	2003	Treatment with antiproliferative folic acid increased IGF-BP3 levels while the proliferative VEGF depleted cellular IGF-BP3 in all the cell lines.	Folic Acid	33-43	insulin like growth factor binding protein 3	Homo sapiens	54-61
14599874-8	2003	We observed increased levels of IGF-BP3 by folic acid, and decreased IGF-BP3 levels by VEGF.	Folic Acid	43-53	insulin like growth factor binding protein 3	Homo sapiens	32-39
14599874-11	2003	Our results suggest that folic acid supplementation can lead to inhibition of cervical cancer cell growth by promoting increased IGF-BP3 levels.	Folic Acid	25-35	insulin like growth factor binding protein 3	Homo sapiens	129-136
14608093-0	2003	Bioaccessibility of folic acid and (6S)-5-methyltetrahydrofolate decreases after the addition of folate-binding protein to yogurt as studied in a dynamic in vitro gastrointestinal model.	Folic Acid	20-30	folate receptor alpha	Homo sapiens	97-119
14578129-13	2003	Given that individuals with high plasma folate had a better survival outcome with a hazard ratio of 0.68 (0.45-1.03) compared with those with low plasma folate, we conclude that the TS promoter polymorphism may modify both the risk and the survival of CRC; however, these effects do not appear to be mediated through its modulation of biological folate levels.	Folic Acid	40-46	thymidylate synthetase	Homo sapiens	182-184
14578129-13	2003	Given that individuals with high plasma folate had a better survival outcome with a hazard ratio of 0.68 (0.45-1.03) compared with those with low plasma folate, we conclude that the TS promoter polymorphism may modify both the risk and the survival of CRC; however, these effects do not appear to be mediated through its modulation of biological folate levels.	Folic Acid	153-159	thymidylate synthetase	Homo sapiens	182-184
14578129-13	2003	Given that individuals with high plasma folate had a better survival outcome with a hazard ratio of 0.68 (0.45-1.03) compared with those with low plasma folate, we conclude that the TS promoter polymorphism may modify both the risk and the survival of CRC; however, these effects do not appear to be mediated through its modulation of biological folate levels.	Folic Acid	153-159	thymidylate synthetase	Homo sapiens	182-184
12899944-4	2003	Among the hepatic proteins affected by ethanol, the concomitant supplementation with folic acid to alcoholic mother rats prevented EF-2, RhoGDI-1, ER-60 protease, and gelsolin depletion.	Folic Acid	85-95	Rho GDP dissociation inhibitor alpha	Rattus norvegicus	137-145
12851689-8	2003	In HCT-8 and DW2 cells at 2.3 and 40 micro M PteGlu, inhibition of DHFR by TMQ induced antithymidylate and antipurine effects; AG2034 and RTX selectively inhibited de novo purine or thymidine synthesis, respectively.	Folic Acid	45-51	dihydrofolate reductase	Homo sapiens	67-71
12851689-11	2003	These results further substantiate the hypothesis that the nonpolyglutamylatable DHFR inhibitor, TMQ, acts as a modulator by decreasing the protection by PteGlu of cells against the polyglutamylatable AG2034 and RTX.	Folic Acid	154-160	dihydrofolate reductase	Homo sapiens	81-85
12874029-7	2003	The FRalpha was capable of binding folates from measurements of [(3)H] folic acid binding, indicating that the overexpressed receptor was properly folded and may mediate vitamin uptake.	Folic Acid	35-42	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	4-11
12874029-7	2003	The FRalpha was capable of binding folates from measurements of [(3)H] folic acid binding, indicating that the overexpressed receptor was properly folded and may mediate vitamin uptake.	Folic Acid	71-81	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	4-11
12684658-1	2003	Thymidylate synthase (TS), a critical enzyme in the de novo synthesis of thymidylate, is an important target for fluoropyrimidines and folate-based TS inhibitors.	Folic Acid	135-141	thymidylate synthetase	Homo sapiens	0-20
12684658-1	2003	Thymidylate synthase (TS), a critical enzyme in the de novo synthesis of thymidylate, is an important target for fluoropyrimidines and folate-based TS inhibitors.	Folic Acid	135-141	thymidylate synthetase	Homo sapiens	22-24
12684658-1	2003	Thymidylate synthase (TS), a critical enzyme in the de novo synthesis of thymidylate, is an important target for fluoropyrimidines and folate-based TS inhibitors.	Folic Acid	135-141	thymidylate synthetase	Homo sapiens	148-150
12663051-12	2003	The data indicate that resistance to pemetrexed in the MTA-13 cell line was due to changes in both RFC and FPGS expression, two proteins that act in tandem to regulate polyglutamation of folates and antifolates in cells, resulting in cellular depletion of these active pemetrexed congeners.	Folic Acid	187-194	folylpolyglutamyl synthetase	Mus musculus	107-111
12482753-2	2003	DHFR retains the capacity to bind folate analogues in the lumen of microsomes and in the ER of intact cells, upon which it acquires a conformation resistant to proteinase K digestion.	Folic Acid	34-40	dihydrofolate reductase	Homo sapiens	0-4
12482753-5	2003	In fact, a slight acceleration of the dislocation of DHFR heavy chain fusion was observed in vitro in the presence of a folate analogue.	Folic Acid	120-126	dihydrofolate reductase	Homo sapiens	53-57
12527324-1	2003	A phosphorous-containing pseudopeptide folate analog (Valiaeva et al., J Org Chem 2001;66:5146-54) was designed to mimic the tetrahedral intermediate formed in the ATP-dependent reaction catalyzed by folylpolyglutamate synthetase (FPGS).	Folic Acid	39-45	folylpolyglutamate synthase	Homo sapiens	200-229
12527324-1	2003	A phosphorous-containing pseudopeptide folate analog (Valiaeva et al., J Org Chem 2001;66:5146-54) was designed to mimic the tetrahedral intermediate formed in the ATP-dependent reaction catalyzed by folylpolyglutamate synthetase (FPGS).	Folic Acid	39-45	folylpolyglutamate synthase	Homo sapiens	231-235
12384802-7	2002	RESULTS: The univariate analysis showed a significant risk reduction with increased intake of beta-carotene, vitamin C, vitamin E, and folic acid for both AC and for SCC.	Folic Acid	135-145	serpin family B member 3	Homo sapiens	166-169
12215845-0	2002	Thymidylate synthase: a novel genetic determinant of plasma homocysteine and folate levels.	Folic Acid	77-83	thymidylate synthetase	Homo sapiens	0-20
12215845-2	2002	We have investigated the relationship between TYMS genotype and plasma concentrations of homocysteine and folate in a cohort of 505 Chinese from Singapore.	Folic Acid	106-112	thymidylate synthetase	Homo sapiens	46-50
12215845-3	2002	TYMS 3/3 genotype was associated with reduced plasma folate and, among individuals with low dietary folate intake, with elevated plasma homocysteine levels.	Folic Acid	53-59	thymidylate synthetase	Homo sapiens	0-4
12215845-3	2002	TYMS 3/3 genotype was associated with reduced plasma folate and, among individuals with low dietary folate intake, with elevated plasma homocysteine levels.	Folic Acid	100-106	thymidylate synthetase	Homo sapiens	0-4
12215845-5	2002	Our results suggest that TYMS and MTHFR compete for limiting supplies of folate required for the remethylation of homocysteine.	Folic Acid	73-79	thymidylate synthetase	Homo sapiens	25-29
12202950-5	2002	Quantitative affinity purification of detergent-insoluble complexes using biotinylated folate or specific antibodies demonstrated a strong association of the homologous FR-alpha and FR-beta in the same detergent-insoluble complex and separate complexes containing either PLAP or caveolin.	Folic Acid	87-93	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	169-177
12202950-5	2002	Quantitative affinity purification of detergent-insoluble complexes using biotinylated folate or specific antibodies demonstrated a strong association of the homologous FR-alpha and FR-beta in the same detergent-insoluble complex and separate complexes containing either PLAP or caveolin.	Folic Acid	87-93	folate receptor beta	Homo sapiens	182-189
12221230-2	2002	Labile folates appear to be stabilized by binding to folate-binding protein (FBP); this paper reports measurements of that stabilization.	Folic Acid	7-14	folate receptor alpha	Bos taurus	53-75
12221230-2	2002	Labile folates appear to be stabilized by binding to folate-binding protein (FBP); this paper reports measurements of that stabilization.	Folic Acid	7-14	folate receptor alpha	Bos taurus	77-80
12221230-6	2002	Stabilization of milk folates may be a role of FBP and would improve the bioavailability of milk folate to newborns and other consumers.	Folic Acid	22-29	folate receptor alpha	Bos taurus	47-50
12221230-6	2002	Stabilization of milk folates may be a role of FBP and would improve the bioavailability of milk folate to newborns and other consumers.	Folic Acid	22-28	folate receptor alpha	Bos taurus	47-50
12091353-4	2002	The posttranslational modification causing its nonfunctionality was evidently absent in FR-beta from AML cells from patient marrow, which bound folate.	Folic Acid	144-150	folate receptor beta	Homo sapiens	88-95
12067974-1	2002	Thymidylate synthase (TS) is a key enzyme in folate metabolism and the primary target of 5-fluorouracil.	Folic Acid	45-51	thymidylate synthetase	Homo sapiens	0-20
12067974-1	2002	Thymidylate synthase (TS) is a key enzyme in folate metabolism and the primary target of 5-fluorouracil.	Folic Acid	45-51	thymidylate synthetase	Homo sapiens	22-24
27264762-6	2002	Two hour postload tHCy, expressed both as absolute value (PML) and as the difference between 2 hour postload tHCy and FtHCy (delta tHCy) was negatively correlated with folate in both sexes, and with vitamin B12 and age in women only.	Folic Acid	168-174	PML nuclear body scaffold	Homo sapiens	58-61
12187485-9	2002	This study represents the first in vitro demonstration of transcellular transfer of folate across RPE and suggests that folate is transported from the choriocapillaris to the adjacent photoreceptor cells in vivo by the concerted action of FR alpha in the basal membrane and RFT-1 in the apical membrane.	Folic Acid	120-126	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	239-247
11818404-12	2002	CONCLUSIONS: These findings demonstrate for the first time that hyperglycemic conditions reduce the expression and activity of RFT-1 and may have profound implications for the transport of folate by RPE in diabetes.	Folic Acid	189-195	RFT1 homolog	Mus musculus	127-132
11772020-1	2002	Folylpoly-gamma-glutamate synthetase (FPGS) is the enzyme responsible for metabolic trapping of reduced folate cofactors in cells for use in nucleotide and amino acid biosynthesis.	Folic Acid	104-110	folylpolyglutamyl synthetase	Mus musculus	0-36
11772020-1	2002	Folylpoly-gamma-glutamate synthetase (FPGS) is the enzyme responsible for metabolic trapping of reduced folate cofactors in cells for use in nucleotide and amino acid biosynthesis.	Folic Acid	104-110	folylpolyglutamyl synthetase	Mus musculus	38-42
16924677-6	2006	The decrease in hepatic miR-122 was a tumor-specific event because it did not occur in the rats switched to the folate and methyl-adequate diet after 36 weeks on deficient diet, which did not lead to hepatocarcinogenesis.	Folic Acid	112-118	microRNA 122	Rattus norvegicus	24-31
16815871-14	2006	Thalidomide and PGA also significantly inhibited P-glycoprotein (PgP/MDR1), multidrug resistance-associated protein (MRP1)- and MRP2-mediated CPT-11 and SN-38 transport in MDCKII cells.	Folic Acid	16-19	PGP	Canis lupus familiaris	65-68
16815871-14	2006	Thalidomide and PGA also significantly inhibited P-glycoprotein (PgP/MDR1), multidrug resistance-associated protein (MRP1)- and MRP2-mediated CPT-11 and SN-38 transport in MDCKII cells.	Folic Acid	16-19	ATP binding cassette subfamily C member 1	Canis lupus familiaris	76-121
17661690-1	2006	Folate metabolism of the malaria parasites provides two targets for current antimalarials: dihydrofolate reductase and dihydropteroate synthase.	Folic Acid	0-6	dihydrofolate reductase	Homo sapiens	91-114
16686541-5	2006	Like 1, this functional activity of 12 in the cell-based assay benefits from and requires transport into the cell by the reduced folate carrier but, unlike 1, is independent of folyl polyglutamate synthase (FPGS) expression levels and polyglutamation.	Folic Acid	129-135	folylpolyglutamate synthase	Homo sapiens	207-211
16470783-7	2006	However, binding of folate induced a distinct increase in FBP-peak symmetry, and using heparin as an affinity displacer, the free FBP in equilibrium with folate-FBP complexes could readily be separated from the complexes.	Folic Acid	20-26	folate receptor alpha	Bos taurus	130-133
16386942-9	2006	Combining the results from the three cross-sectional studies, a negative correlation between folate status and fMN-Trf-Ret was obtained (p&lt;0.05).	Folic Acid	93-99	ret proto-oncogene	Homo sapiens	119-122
16010590-14	2006	The drug interaction may partly be dependent on the folate homeostasis since WiDr/F cells growing at low folate conditions show pronounced synergism in growth inhibition, two-sided TS inhibition and DNA damage, especially when TFT is combined with the tight-binding TS inhibitor GW1843.	Folic Acid	105-111	thymidylate synthetase	Homo sapiens	181-183
16010590-14	2006	The drug interaction may partly be dependent on the folate homeostasis since WiDr/F cells growing at low folate conditions show pronounced synergism in growth inhibition, two-sided TS inhibition and DNA damage, especially when TFT is combined with the tight-binding TS inhibitor GW1843.	Folic Acid	105-111	thymidylate synthetase	Homo sapiens	266-268
16475900-12	2006	Further studies of mutations in the 5"-UTR of FOLR1, and in particular of their interplay with folate intake status, are warranted.	Folic Acid	95-101	folate receptor alpha	Homo sapiens	46-51
16306263-8	2005	These studies demonstrate that the folic acid conjugation to the Lys side-chain amino groups blocks binding to the normal LDL receptor and reroutes the resulting conjugate to cancer cells through their FRs.	Folic Acid	35-45	low density lipoprotein receptor	Homo sapiens	122-134
16043641-1	2005	BACKGROUND: Methionine synthase (MS) catalyzes the folate-dependent remethylation of homocysteine to methionine.	Folic Acid	51-57	5-methyltetrahydrofolate-homocysteine methyltransferase	Mus musculus	12-31
15817609-7	2005	More importantly, a significant interaction between the TS polymorphisms and serum folate status in risk of ESCC and GCA was observed.	Folic Acid	83-89	thymidylate synthetase	Homo sapiens	56-58
16010439-1	2005	The folate analogue BGC9331 is a new thymidylate synthase (TS) inhibitor showing a broad spectrum of cyto-toxic activity against several human solid tumors, including colorectal cancer.	Folic Acid	4-10	thymidylate synthetase	Homo sapiens	37-57
16046727-2	2005	The cytoplasmic serine hydroxymethyltransferase (cSHMT) enzyme is proposed to regulate a key metabolic intersection in folate metabolism.	Folic Acid	119-125	serine hydroxymethyltransferase 1	Homo sapiens	4-47
16046727-2	2005	The cytoplasmic serine hydroxymethyltransferase (cSHMT) enzyme is proposed to regulate a key metabolic intersection in folate metabolism.	Folic Acid	119-125	serine hydroxymethyltransferase 1	Homo sapiens	49-54
16006999-2	2005	We hypothesized that polymorphisms of the cytosolic serine hydroxymethyltransferase (SHMT1) gene involved in folate-dependent, one-carbon metabolism are associated with SCCHN risk.	Folic Acid	109-115	serine hydroxymethyltransferase 1	Homo sapiens	42-83
16006999-2	2005	We hypothesized that polymorphisms of the cytosolic serine hydroxymethyltransferase (SHMT1) gene involved in folate-dependent, one-carbon metabolism are associated with SCCHN risk.	Folic Acid	109-115	serine hydroxymethyltransferase 1	Homo sapiens	85-90
16178442-0	2005	[Folate reduces monocyte chemoattractant protein-1 expression in rats with hyperhomocysteinemia].	Folic Acid	1-7	C-C motif chemokine ligand 2	Rattus norvegicus	16-50
16178442-1	2005	OBJECTIVE: To investigate effects of supplementation of folate on the expression of monocyte chemoattractant protein-1 (MCP-1) in aortic endothelium and release from peripheral blood mononuclear cells (PBMC) in rats with hyperhomocysteinemia induced by ingestion of excess methionine.	Folic Acid	56-62	C-C motif chemokine ligand 2	Rattus norvegicus	84-118
16178442-1	2005	OBJECTIVE: To investigate effects of supplementation of folate on the expression of monocyte chemoattractant protein-1 (MCP-1) in aortic endothelium and release from peripheral blood mononuclear cells (PBMC) in rats with hyperhomocysteinemia induced by ingestion of excess methionine.	Folic Acid	56-62	C-C motif chemokine ligand 2	Rattus norvegicus	120-125
16178442-9	2005	During supplementation of folate, normalization of Thcy levels was accompanied by a marked reduction of MCP-1 expression in aortic endothelium and by a significant decrease of MCP-1 released from PBMC stimulated by oxidized low density lipoprotein (P &lt; 0.05, P &lt; 0.01).	Folic Acid	26-32	C-C motif chemokine ligand 2	Rattus norvegicus	104-109
16178442-9	2005	During supplementation of folate, normalization of Thcy levels was accompanied by a marked reduction of MCP-1 expression in aortic endothelium and by a significant decrease of MCP-1 released from PBMC stimulated by oxidized low density lipoprotein (P &lt; 0.05, P &lt; 0.01).	Folic Acid	26-32	C-C motif chemokine ligand 2	Rattus norvegicus	176-181
16178442-10	2005	CONCLUSION: Folate supplementation can prevent an elevation of homocysteine levels in the blood and decrease the expression MCP-1 in aortic endothelium and release of MCP-1 from PBMC in rats with hyperhomocysteinemia.	Folic Acid	12-18	C-C motif chemokine ligand 2	Rattus norvegicus	124-129
16178442-10	2005	CONCLUSION: Folate supplementation can prevent an elevation of homocysteine levels in the blood and decrease the expression MCP-1 in aortic endothelium and release of MCP-1 from PBMC in rats with hyperhomocysteinemia.	Folic Acid	12-18	C-C motif chemokine ligand 2	Rattus norvegicus	167-172
15800851-2	2005	Folic acid-binding protein one (Folbp1), a membrane-bounded protein, is the primary mediator of folic acid transport.	Folic Acid	0-10	folate receptor 1 (adult)	Mus musculus	32-38
15800851-2	2005	Folic acid-binding protein one (Folbp1), a membrane-bounded protein, is the primary mediator of folic acid transport.	Folic Acid	96-106	folate receptor 1 (adult)	Mus musculus	32-38
15705579-4	2005	FolC structure revealed an unexpected dihydropteroate binding site very different from the folate site identified previously in the FPGS structure.	Folic Acid	91-97	folylpolyglutamate synthase	Homo sapiens	132-136
15705579-7	2005	As such, the presence of a folate binding site in E. coli FolC, which is different from the one seen in FPGS enzymes, provides avenues for the design of specific inhibitors of this enzyme in antimicrobial therapy.	Folic Acid	27-33	folylpolyglutamate synthase	Homo sapiens	104-108
16178783-4	2005	Thymidylate synthase (TS or ThyA) has long been considered as one of the best-known drug targets in the anti-cancer area, after which old and new drugs, such as 5-fluoro uracil and the anti-folate ZD1694, have been introduced into chemotherapy to treat solid tumours.	Folic Acid	190-196	thymidylate synthetase	Homo sapiens	0-20
16045580-1	2005	SUMMARY: Methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS) are key enzymes in folate metabolism, which is essential for normal DNA methylation and synthesis.	Folic Acid	28-34	thymidylate synthetase	Homo sapiens	57-77
15510613-2	2004	Functional genetic variants in the methylene tetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS) genes may be risk factors for breast cancer because of their central roles in cellular folate metabolism.	Folic Acid	55-61	thymidylate synthetase	Homo sapiens	106-108
15306169-12	2004	Lastly, folate levels may need to reach a critically low status before an association can be found between folate and CIMT.	Folic Acid	107-113	CIMT	Homo sapiens	118-122
15169867-4	2004	Expression of the budding yeast gene FOL1 in Escherichia coli identified the folate biosynthetic enzyme activities dihydroneopterin aldolase (DHNA), 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK), and dihydropteroate synthase (DHPS).	Folic Acid	77-83	trifunctional dihydropteroate synthetase/dihydrohydroxymethylpterin pyrophosphokinase/dihydroneopterin aldolase FOL1	Saccharomyces cerevisiae S288C	37-41
15169867-4	2004	Expression of the budding yeast gene FOL1 in Escherichia coli identified the folate biosynthetic enzyme activities dihydroneopterin aldolase (DHNA), 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK), and dihydropteroate synthase (DHPS).	Folic Acid	77-83	Dihydropteroate synthase	Escherichia coli	213-237
15169867-4	2004	Expression of the budding yeast gene FOL1 in Escherichia coli identified the folate biosynthetic enzyme activities dihydroneopterin aldolase (DHNA), 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK), and dihydropteroate synthase (DHPS).	Folic Acid	77-83	Dihydropteroate synthase	Escherichia coli	239-243
14998787-13	2004	Evidence also was found suggesting that the folate uptake process by MIA PaCa-2 cells is regulated by cAMP- and protein tyrosine kinase (PTK)-mediated pathways.	Folic Acid	44-50	protein tyrosine kinase 2 beta	Homo sapiens	137-140
14998787-15	2004	The results also show the involvement of hRFC in the uptake process and suggest the possible involvement of intracellular cAMP- and PTK-mediated pathways in the regulation of folate uptake.	Folic Acid	175-181	protein tyrosine kinase 2 beta	Homo sapiens	132-135
15225321-3	2004	We have isolated PAS-resistant transposon mutants of Mycobacterium bovis BCG with insertions in the thymidylate synthase (thyA) gene, a critical determinant of intracellular folate levels.	Folic Acid	174-180	thymidylate synthetase	Homo sapiens	100-120
15225321-3	2004	We have isolated PAS-resistant transposon mutants of Mycobacterium bovis BCG with insertions in the thymidylate synthase (thyA) gene, a critical determinant of intracellular folate levels.	Folic Acid	174-180	thymidylate synthetase	Homo sapiens	122-126
15225321-4	2004	BCG thyA mutants have reduced thymidylate synthase activity and are resistant to known inhibitors of the folate pathway.	Folic Acid	105-111	thymidylate synthetase	Homo sapiens	4-8
15225321-7	2004	Thus, PAS acts in the folate pathway, and thyA mutations probably represent a mechanism of developing resistance not only to PAS but also to other drugs that target folate metabolism.	Folic Acid	165-171	thymidylate synthetase	Homo sapiens	42-46
15182183-17	2004	Isothermal titration calorimetry studies were also conducted on many of the mutants described above to determine the enthalpy of folate binding to the R67 DHFR.NADPH complex.	Folic Acid	129-135	dihydrofolate reductase	Homo sapiens	155-159
15213241-1	2004	To address the effects of ligand binding on the structural fluctuations of Escherichia coli dihydrofolate reductase (DHFR), the hydrogen/deuterium (H/D) exchange kinetics of its binary and ternary complexes formed with various ligands (folate, dihydrofolate, tetrahydrofolate, NADPH, NADP(+), and methotrexate) were examined using electrospray ionization mass spectrometry.	Folic Acid	99-105	Dihydrofolate reductase	Escherichia coli	117-121
15176467-0	2004	Folate-regulated changes in gene expression in the anterior neural tube of folate binding protein-1 (Folbp1)-deficient murine embryos.	Folic Acid	0-6	folate receptor 1 (adult)	Mus musculus	75-99
15176467-0	2004	Folate-regulated changes in gene expression in the anterior neural tube of folate binding protein-1 (Folbp1)-deficient murine embryos.	Folic Acid	0-6	folate receptor 1 (adult)	Mus musculus	101-107
15105297-6	2004	Tg-CBS mice maintained on a high-methionine, low-folate diet also had significantly lower serum homocysteine compared with control animals (179 micromol/L versus 242 micromol/L; P&lt;0.02).	Folic Acid	49-55	cystathionine beta-synthase	Mus musculus	3-6
24205192-1	2013	The proton-coupled folate transporter (PCFT) was recently identified as the major uptake route for dietary folates in humans.	Folic Acid	107-114	solute carrier family 46 member 1	Homo sapiens	39-43
15211800-7	2004	Folic acid upregulated c-IAP2 expression while attenuating Hcy-induced apoptosis and caspase3 activation.	Folic Acid	0-10	baculoviral IAP repeat containing 3	Homo sapiens	23-29
15211800-8	2004	CONCLUSION: Hcy may induce HUVEC apoptosis via a pathway involving caspase3, which can be partially antagonized by folic acid, possibly through upregulated c-IAP2 expression.	Folic Acid	115-125	baculoviral IAP repeat containing 3	Homo sapiens	156-162
24045662-1	2013	BACKGROUND: gamma-Glutamyl hydrolase (GGH) regulates intracellular folate and antifolates for optimal nucleotide biosynthesis and antifolate-induced cytotoxicity, respectively.	Folic Acid	67-73	gamma-glutamyl hydrolase	Homo sapiens	12-36
15244514-8	2004	The present results suggest that TS polymorphism may modify the risk of esophageal and stomach cancer with smoking, pointing to the necessity for further investigations with information on folate and methionine intake with a larger population.	Folic Acid	189-195	thymidylate synthetase	Homo sapiens	33-35
24045662-1	2013	BACKGROUND: gamma-Glutamyl hydrolase (GGH) regulates intracellular folate and antifolates for optimal nucleotide biosynthesis and antifolate-induced cytotoxicity, respectively.	Folic Acid	67-73	gamma-glutamyl hydrolase	Homo sapiens	38-41
24053355-1	2013	Most species, such as humans, have monofunctional forms of thymidylate synthase (TS) and dihydrofolate reductase (DHFR) that are key folate metabolism enzymes making critical folate components required for DNA synthesis.	Folic Acid	96-102	thymidylate synthetase	Homo sapiens	59-79
14600030-10	2004	In folic acid-treated kidneys, Kim-1 is clearly localized to the apical brush border of the well-differentiated proximal tubular epithelial cells.	Folic Acid	3-13	hepatitis A virus cellular receptor 1	Rattus norvegicus	31-36
14600030-11	2004	After folic acid treatment, expression of Kim-1 is present in the urine despite no significant increase in serum creatinine.	Folic Acid	6-16	hepatitis A virus cellular receptor 1	Rattus norvegicus	42-47
14662146-7	2004	The folic acid+glycine supplement tended (P&lt;0.07) to increase allantoic content of PGE2 and TGF-beta2 in all sows and increased (P&lt;0.05) endometrial expression of COX2, especially in NYL sows.	Folic Acid	4-14	transforming growth factor beta 2	Sus scrofa	95-104
14662146-8	2004	The endometrial expression of COX1 was decreased (P&lt;0.05) by folic acid+glycine supplement, especially in multiparous YL sows.	Folic Acid	64-74	cytochrome c oxidase subunit I	Sus scrofa	30-34
12970065-8	2004	In folate-deficient rats, aging induced the down-regulation of immune-related genes, urokinase, p53, insulin-like growth factor binding protein-3 and vav-1 oncogene.	Folic Acid	3-9	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	96-99
24053355-1	2013	Most species, such as humans, have monofunctional forms of thymidylate synthase (TS) and dihydrofolate reductase (DHFR) that are key folate metabolism enzymes making critical folate components required for DNA synthesis.	Folic Acid	96-102	dihydrofolate reductase	Homo sapiens	114-118
24053355-1	2013	Most species, such as humans, have monofunctional forms of thymidylate synthase (TS) and dihydrofolate reductase (DHFR) that are key folate metabolism enzymes making critical folate components required for DNA synthesis.	Folic Acid	133-139	thymidylate synthetase	Homo sapiens	59-79
24053355-1	2013	Most species, such as humans, have monofunctional forms of thymidylate synthase (TS) and dihydrofolate reductase (DHFR) that are key folate metabolism enzymes making critical folate components required for DNA synthesis.	Folic Acid	133-139	dihydrofolate reductase	Homo sapiens	89-112
24053355-1	2013	Most species, such as humans, have monofunctional forms of thymidylate synthase (TS) and dihydrofolate reductase (DHFR) that are key folate metabolism enzymes making critical folate components required for DNA synthesis.	Folic Acid	133-139	dihydrofolate reductase	Homo sapiens	114-118
23707606-13	2013	Activity assays verified that human DHFR has very low affinity for 7,8-BH2 (DHF&lt;Km&gt;7,8-BH2) and folic acid inhibits 7,8-BH2 recycling.	Folic Acid	102-112	dihydrofolate reductase	Homo sapiens	36-40
23707606-14	2013	We conclude that low activity of endothelial DHFR is an important factor limiting the benefits of BH4 therapies, which may be further aggravated by folate supplements.	Folic Acid	148-154	dihydrofolate reductase	Homo sapiens	45-49
23824605-11	2013	Importantly, SARDH and/or TMEFF2 KD promote increased cellular invasion, sensitize the cell to methotrexate, render the cell resistant to invasion induced by sarcosine, a metabolite from the folate-mediated 1-C metabolism pathway, and affect the expression level of enzymes involved in that pathway.	Folic Acid	191-197	transmembrane protein with EGF like and two follistatin like domains 2	Homo sapiens	26-32
23816405-1	2013	Hereditary folate malabsorption (OMIM 229050) is a rare autosomal recessive disorder caused by loss-of-function mutations in the proton-coupled folate transporter gene (pcft/SLC46A1) resulting in impaired folate transport across the intestine and into the central nervous system.	Folic Acid	11-17	solute carrier family 46 member 1	Homo sapiens	129-162
12970065-8	2004	In folate-deficient rats, aging induced the down-regulation of immune-related genes, urokinase, p53, insulin-like growth factor binding protein-3 and vav-1 oncogene.	Folic Acid	3-9	insulin-like growth factor binding protein 3	Rattus norvegicus	101-145
12970065-11	2004	An age-related decline in p53 and IGF-BP3 expression was only observed in folate depleted animals, indicating that folate supplementation may reduce the risk for age-associated cancers by suppressing deleterious changes in the expression of certain genes.	Folic Acid	74-80	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	26-29
12970065-11	2004	An age-related decline in p53 and IGF-BP3 expression was only observed in folate depleted animals, indicating that folate supplementation may reduce the risk for age-associated cancers by suppressing deleterious changes in the expression of certain genes.	Folic Acid	74-80	insulin-like growth factor binding protein 3	Rattus norvegicus	34-41
12970065-11	2004	An age-related decline in p53 and IGF-BP3 expression was only observed in folate depleted animals, indicating that folate supplementation may reduce the risk for age-associated cancers by suppressing deleterious changes in the expression of certain genes.	Folic Acid	115-121	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	26-29
12970065-11	2004	An age-related decline in p53 and IGF-BP3 expression was only observed in folate depleted animals, indicating that folate supplementation may reduce the risk for age-associated cancers by suppressing deleterious changes in the expression of certain genes.	Folic Acid	115-121	insulin-like growth factor binding protein 3	Rattus norvegicus	34-41
11772020-9	2002	We drew the conclusion that the decreased sensitivity of the FPGS expressed in mouse liver and kidney to feedback inhibition by 5,10-CH(2)-H(4)PteGlu(5-6) and H(4)PteGlu(5-6) may have evolved to permit accumulation of a larger folate cofactor pool than that found within rapidly proliferating tissue.	Folic Acid	143-149	folylpolyglutamyl synthetase	Mus musculus	61-65
11772020-9	2002	We drew the conclusion that the decreased sensitivity of the FPGS expressed in mouse liver and kidney to feedback inhibition by 5,10-CH(2)-H(4)PteGlu(5-6) and H(4)PteGlu(5-6) may have evolved to permit accumulation of a larger folate cofactor pool than that found within rapidly proliferating tissue.	Folic Acid	163-169	folylpolyglutamyl synthetase	Mus musculus	61-65
11772020-9	2002	We drew the conclusion that the decreased sensitivity of the FPGS expressed in mouse liver and kidney to feedback inhibition by 5,10-CH(2)-H(4)PteGlu(5-6) and H(4)PteGlu(5-6) may have evolved to permit accumulation of a larger folate cofactor pool than that found within rapidly proliferating tissue.	Folic Acid	227-233	folylpolyglutamyl synthetase	Mus musculus	61-65
23816405-1	2013	Hereditary folate malabsorption (OMIM 229050) is a rare autosomal recessive disorder caused by loss-of-function mutations in the proton-coupled folate transporter gene (pcft/SLC46A1) resulting in impaired folate transport across the intestine and into the central nervous system.	Folic Acid	11-17	solute carrier family 46 member 1	Homo sapiens	169-173
23816405-1	2013	Hereditary folate malabsorption (OMIM 229050) is a rare autosomal recessive disorder caused by loss-of-function mutations in the proton-coupled folate transporter gene (pcft/SLC46A1) resulting in impaired folate transport across the intestine and into the central nervous system.	Folic Acid	11-17	solute carrier family 46 member 1	Homo sapiens	174-181
14660354-6	2003	The production of bioavailable monoglutamyl folate and almost complete release of folate from the bacterium was achieved by expressing the gene for gamma-glutamyl hydrolase from human or rat origin.	Folic Acid	44-50	gamma-glutamyl hydrolase	Homo sapiens	148-172
24059870-3	2013	By focusing on four essential energy-requiring CP functions, specifically ascorbic acid (AA) and folate transport from blood into CSF, transthyretin synthesis and secretion into CSF, and electrolyte/acid-base balance in CSF, we were able to evaluate the hypothesis of CP failure by reviewing definitive human data.	Folic Acid	97-103	colony stimulating factor 2	Homo sapiens	130-133
14581169-2	2003	Folbp1 (folate binding protein-1) mediated intracellular folate uptake is one route by which cells harvest folate cofactors.	Folic Acid	8-14	folate receptor 1 (adult)	Mus musculus	0-6
14581169-2	2003	Folbp1 (folate binding protein-1) mediated intracellular folate uptake is one route by which cells harvest folate cofactors.	Folic Acid	57-63	folate receptor 1 (adult)	Mus musculus	0-6
24023349-1	2013	AIM: To analyze associations between homocysteine level, MTHFR and FTO rs1477196 polymorphisms and folate status in patients with breast cancer (BC) in order to clarify determinants of hyperhomocysteinemia.	Folic Acid	99-105	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	67-70
14581169-2	2003	Folbp1 (folate binding protein-1) mediated intracellular folate uptake is one route by which cells harvest folate cofactors.	Folic Acid	57-63	folate receptor 1 (adult)	Mus musculus	8-32
14581169-5	2003	Folbp1(-/-) mice excreted more dimethylarsinic acid than wildtype control mice during folate deficiency, but not during normal folate intake.	Folic Acid	86-92	folate receptor 1 (adult)	Mus musculus	0-6
14745930-1	2003	BACKGROUND: Polymorphisms within the thymidylate synthase (TS) gene that influence enzyme activity may affect plasma folate levels and, indirectly, plasma homocysteine concentrations.	Folic Acid	117-123	thymidylate synthetase	Homo sapiens	37-57
14745930-1	2003	BACKGROUND: Polymorphisms within the thymidylate synthase (TS) gene that influence enzyme activity may affect plasma folate levels and, indirectly, plasma homocysteine concentrations.	Folic Acid	117-123	thymidylate synthetase	Homo sapiens	59-61
23777916-4	2013	The folate moiety binds quickly to PSMA-positive tumors, and the PSA-responsive moiety is cleaved by PSA that was enriched in tumor tissues.	Folic Acid	4-10	kallikrein related peptidase 3	Homo sapiens	101-104
23881211-7	2013	In contrast, MTX transport mediated by PCFT, the mechanism of folate/antifolate absorption in the small intestine, exceeded that for pralatrexate.	Folic Acid	62-68	solute carrier family 46 member 1	Homo sapiens	39-43
23799623-10	2013	Exogenously added folic acid reversed the MTX-mediated DHFR inhibition following either MTX or MTX + ASA treatments.	Folic Acid	18-28	dihydrofolate reductase	Homo sapiens	55-59
23538095-1	2013	Folate conjugated amphiphilic polymeric micelles have attracted much attention for active targeted delivery of drugs in folate receptor alpha (FR-alpha) positive tumors.	Folic Acid	0-6	folate receptor alpha	Homo sapiens	120-141
23538095-1	2013	Folate conjugated amphiphilic polymeric micelles have attracted much attention for active targeted delivery of drugs in folate receptor alpha (FR-alpha) positive tumors.	Folic Acid	0-6	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	143-151
23538095-2	2013	However, the efficacy improvement of targeted delivery folate-based nanovehicles was limited by the abundance of FR-alpha on the surface of tumor cells.	Folic Acid	55-61	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	113-121
23538095-7	2013	Moreover, the antitumor activity of folate-conjugated micellar MTN was also improved through up-regulation of FR-alpha.	Folic Acid	36-42	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	110-118
23538095-8	2013	Therefore, FR-alpha up-regulation using modulators has great potential to improve the therapeutic efficacy of folate-conjugated nanovehicles in some FR-alpha positive tumors via receptor-mediated endocytosis.	Folic Acid	110-116	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	11-19
23538095-8	2013	Therefore, FR-alpha up-regulation using modulators has great potential to improve the therapeutic efficacy of folate-conjugated nanovehicles in some FR-alpha positive tumors via receptor-mediated endocytosis.	Folic Acid	110-116	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	149-157
23802413-7	2013	The transfection activity of F-targeted lipoplexes could be competitively inhibited by free folic acid, demonstrating that folate-FRalpha interaction caused high transfection efficiency of F-targeted lipoplexes.	Folic Acid	92-102	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	130-137
23449276-3	2013	Pemetrexed is an antifolate inhibiting different folate pathway genes (thymidylate synthase [TS], dihydrofolate reductase, glycinamide ribonucleotide formyltransferase [GARFT], and aminoimidazole carboxamide ribonucleotide formyltransferase, [AICARFT]).	Folic Acid	21-27	thymidylate synthetase	Homo sapiens	71-91
23364519-6	2013	PTHrP(1-36) protected renal tubuloepithelial cells from folic acid toxicity and serum deprivation, an effect inhibited by a dominant-negative Runx2 construct or a Runx2 siRNA.	Folic Acid	56-66	runt related transcription factor 2	Mus musculus	142-147
23364519-6	2013	PTHrP(1-36) protected renal tubuloepithelial cells from folic acid toxicity and serum deprivation, an effect inhibited by a dominant-negative Runx2 construct or a Runx2 siRNA.	Folic Acid	56-66	runt related transcription factor 2	Mus musculus	163-168
23219837-0	2013	Folic acid enforces DNA methylation-mediated transcriptional silencing of PTEN, APC and RARbeta2 tumour suppressor genes in breast cancer.	Folic Acid	0-10	phosphatase and tensin homolog	Homo sapiens	74-78
23219837-3	2013	Using the methylation sensitive restriction analysis (MSRA) and real-time RT-PCR we tested the effect of folic acid on DNA promoter methylation and expression of PTEN, APC and RARbeta2 tumour suppressor genes in MCF-7 and MDA-MB-231 breast cancer cell lines with different invasive capacity.	Folic Acid	105-115	phosphatase and tensin homolog	Homo sapiens	162-166
27122685-8	2013	The relationships between CIMT and serum folic acid level (r = -0.212; p = 0.072) or statin usage (r = 0.207; p = 0.079) were borderline significant.	Folic Acid	41-51	CIMT	Homo sapiens	26-30
23242435-1	2013	INTRODUCTION: Folate receptor alpha (FRA) regulates cellular uptake of folates and antifolates.	Folic Acid	71-78	folate receptor alpha	Homo sapiens	14-35
23242435-1	2013	INTRODUCTION: Folate receptor alpha (FRA) regulates cellular uptake of folates and antifolates.	Folic Acid	71-78	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	37-40
22731739-5	2012	RESULTS:   By the end of the follow-on study, the PGA response rate to the subsequent course of alitretinoin 30 mg was 50% and 39% in patients treated previously in BACH with 10 or 30 mg per day, respectively, and 51% in patients who previously received placebo in BACH.	Folic Acid	50-53	acyl-CoA thioesterase 7	Homo sapiens	165-169
22731739-5	2012	RESULTS:   By the end of the follow-on study, the PGA response rate to the subsequent course of alitretinoin 30 mg was 50% and 39% in patients treated previously in BACH with 10 or 30 mg per day, respectively, and 51% in patients who previously received placebo in BACH.	Folic Acid	50-53	acyl-CoA thioesterase 7	Homo sapiens	265-269
22530664-2	2012	MTX is a folate analog that inhibits dihydrofolate reductase, thereby blocking de novo purine synthesis.	Folic Acid	9-15	dihydrofolate reductase	Homo sapiens	37-60
14652292-9	2003	These data indicate that dietary folate supplementation at 4x the basal dietary requirement significantly suppresses UC-associated colorectal carcinogenesis in the IL-2(null) x beta(2)m(null) mice.	Folic Acid	33-39	interleukin 2	Mus musculus	164-168
14599874-2	2003	As folate deficiency is a risk factor in cervical cancer, we sought to determine if folic acid treatment might increase IGF-BP3 production, thereby inhibiting malignant cell proliferation.	Folic Acid	84-94	insulin like growth factor binding protein 3	Homo sapiens	120-127
14502550-1	2003	Pyrimethamine, an antimalarial drug, was found to be able to inhibit both enzymes (DHFR-TS and PTR1) of the leishmanial folate pathway, although this effect in vivo appears only in relatively high concentrations.	Folic Acid	120-126	dihydrofolate reductase	Homo sapiens	83-87
12757380-4	2003	In this work we attempted to develop long-circulating PEGylated carboplatin analogues with improved cell permeation abilities, by conjugating the platinum moiety to folate-targeted PEG carriers capable of utilizing the folate receptor-mediated endocytosis (FRME).	Folic Acid	165-171	progestagen associated endometrial protein	Homo sapiens	54-57
12757380-6	2003	Folate-targeted PEG conjugates enter the cells efficiently by the FRME pathway but form relatively few DNA adducts and have higher IC(50) values than carboplatin and their nontargeted analogues.	Folic Acid	0-6	progestagen associated endometrial protein	Homo sapiens	16-19
12757380-9	2003	The findings of this study suggest that folate-targeted conjugates such as FA-PEG-Pt, may not be an optimal prodrug for the carboplatin family compounds, because the conjugates or the active moieties are neutralized or blocked during the FRME process and do not manage to effectively reach the nuclear DNA.	Folic Acid	40-46	progestagen associated endometrial protein	Homo sapiens	78-81
12684695-2	2003	Thymidylate synthase (TS) and methylenetetrahydrofolate reductase (MTHFR) are key enzymes in the folate metabolism and both have been shown to be polymorphic affecting the enzyme activity.	Folic Acid	49-55	thymidylate synthetase	Homo sapiens	22-24
12854656-2	2003	Mice deficient in the folic acid-binding protein one (Folbp1) gene display multiple developmental abnormalities, including neural and craniofacial defects.	Folic Acid	22-32	folate receptor 1 (adult)	Mus musculus	54-60
14529544-14	2003	Thus in rational design and in structure-based design studies, two new classes of antifolate enzyme inhibitors were elaborated-direct inhibitors of thymidylate synthase (TMPS) and direct inhibitors of one or both of the two folate-dependent enzymes of de novo purine synthesis.	Folic Acid	86-92	thymidylate synthetase	Homo sapiens	148-168
12508232-2	2003	Folate-binding protein 1 (FBP1) is one of the membrane proteins that mediate cellular uptake of folate.	Folic Acid	96-102	folate receptor 1 (adult)	Mus musculus	0-24
12508232-2	2003	Folate-binding protein 1 (FBP1) is one of the membrane proteins that mediate cellular uptake of folate.	Folic Acid	96-102	folate receptor 1 (adult)	Mus musculus	26-30
12508232-9	2003	Fbp1 also showed intense expression in the yolk sac, indicating that FBP1 may mediate transferring maternal folate to embryos during neurulation.	Folic Acid	108-114	folate receptor 1 (adult)	Mus musculus	0-4
12508232-9	2003	Fbp1 also showed intense expression in the yolk sac, indicating that FBP1 may mediate transferring maternal folate to embryos during neurulation.	Folic Acid	108-114	folate receptor 1 (adult)	Mus musculus	69-73
12161434-0	2002	Cytoplasmic serine hydroxymethyltransferase mediates competition between folate-dependent deoxyribonucleotide and S-adenosylmethionine biosyntheses.	Folic Acid	73-79	serine hydroxymethyltransferase 1	Homo sapiens	0-43
12138190-5	2002	SHMT enzymes are the major source of the one-carbon unit required for folate metabolism and for the biosynthesis of nucleotides and amino acids.	Folic Acid	70-76	serine hydroxymethyltransferase 1	Homo sapiens	0-4
12084459-1	2002	Studies from our laboratory have shown that the folate-dependent enzyme, thymidylate synthase (TS), functions as an RNA binding protein.	Folic Acid	48-54	thymidylate synthetase	Homo sapiens	73-93
12084459-1	2002	Studies from our laboratory have shown that the folate-dependent enzyme, thymidylate synthase (TS), functions as an RNA binding protein.	Folic Acid	48-54	thymidylate synthetase	Homo sapiens	95-97
12084461-2	2002	TS is an important target for chemotherapy; it is inhibited by folate and nucleotide analogs, such as by 5-fluoro-dUMP (FdUMP), the active metabolite of 5-fluorouracil (5FU).	Folic Acid	63-69	thymidylate synthetase	Homo sapiens	0-2
12054489-3	2002	Inappropriate regulation of GNMT may have negative consequences on methyl group and folate metabolism.	Folic Acid	84-90	glycine N-methyltransferase	Rattus norvegicus	28-32
12052139-1	2002	Folate metabolism is the target of two major drug groups: folate antagonists (e.g., methotrexate) and thymidylate synthase inhibitors (for example, 5-fluorouracil).	Folic Acid	0-6	thymidylate synthetase	Homo sapiens	102-122
12023790-8	2002	Pemetrexed, a folate-based inhibitor of thymidylate synthase and other enzymes, is currently under investigation in multiple malignancies.	Folic Acid	14-20	thymidylate synthetase	Homo sapiens	40-60
11989624-6	2001	The bound pteridine ring of folate (Fol I) from the crystal structure of R67 DHFR was used as the basis for docking the nicotinamide-ribose-Pi (NMN) moiety of NADPH.	Folic Acid	28-34	dihydrofolate reductase	Homo sapiens	77-81
11305908-3	2001	Cytoplasmic SHMT (cSHMT) has been postulated to channel one-carbon substituted folates to various folate-dependent enzymes, and alternative splicing of the cSHMT transcript may be a mechanism that enables specific protein-protein interactions.	Folic Acid	79-86	serine hydroxymethyltransferase 1	Homo sapiens	18-23
11305908-3	2001	Cytoplasmic SHMT (cSHMT) has been postulated to channel one-carbon substituted folates to various folate-dependent enzymes, and alternative splicing of the cSHMT transcript may be a mechanism that enables specific protein-protein interactions.	Folic Acid	79-85	serine hydroxymethyltransferase 1	Homo sapiens	18-23
12449732-1	2002	Raltitrexed (Tomudex), a classical folate antagonist, is a selective inhibitor of thymidylate synthase (TS).	Folic Acid	35-41	thymidylate synthetase	Homo sapiens	82-102
12449732-1	2002	Raltitrexed (Tomudex), a classical folate antagonist, is a selective inhibitor of thymidylate synthase (TS).	Folic Acid	35-41	thymidylate synthetase	Homo sapiens	104-106
12166823-0	2001	Binding of radiolabeled folate and 5-methyltetrahydrofolate to cow"s milk folate binding protein at pH 7.4 and 5.0.	Folic Acid	24-30	folate receptor alpha	Bos taurus	69-96
11731153-5	2001	The folic acid synthesis pathway in the folate utilising isolates was restored via transformation with FOL1 or FOL3 expression plasmids and transformants were tested for resistance to sulfamethoxazole (SMX).	Folic Acid	4-14	trifunctional dihydropteroate synthetase/dihydrohydroxymethylpterin pyrophosphokinase/dihydroneopterin aldolase FOL1	Saccharomyces cerevisiae S288C	103-107
11731153-5	2001	The folic acid synthesis pathway in the folate utilising isolates was restored via transformation with FOL1 or FOL3 expression plasmids and transformants were tested for resistance to sulfamethoxazole (SMX).	Folic Acid	40-46	trifunctional dihydropteroate synthetase/dihydrohydroxymethylpterin pyrophosphokinase/dihydroneopterin aldolase FOL1	Saccharomyces cerevisiae S288C	103-107
12450432-1	2001	Thymidylate synthase (TS) is an important target for chemotherapy drugs, such as 5-fluorouracil (5-FU), 5-fluorodeoxyuridine (FUDR), oral 5-FU prodrugs (e.g., uracil/tegafur [UFT], S-1, and capecitabine), and other novel folate-based drugs (e.g., raltitrexed, pemetrexed, and nolatrexed).	Folic Acid	221-227	thymidylate synthetase	Homo sapiens	0-20
12450432-1	2001	Thymidylate synthase (TS) is an important target for chemotherapy drugs, such as 5-fluorouracil (5-FU), 5-fluorodeoxyuridine (FUDR), oral 5-FU prodrugs (e.g., uracil/tegafur [UFT], S-1, and capecitabine), and other novel folate-based drugs (e.g., raltitrexed, pemetrexed, and nolatrexed).	Folic Acid	221-227	thymidylate synthetase	Homo sapiens	22-24
11516159-1	2001	The role of cytosolic and mitochondrial serine hydroxymethyltransferase in supplying one-carbon groups for purine and thymidylate biosynthesis in MCF-7 cells was investigated by observing folate-mediated one-carbon metabolism of l-[3-(13)C]serine, [2-(13)C]glycine, and [(13)C]formate.	Folic Acid	188-194	serine hydroxymethyltransferase 1	Homo sapiens	12-71
11774738-2	2001	The cells acquired resistance to antifolate drug(s) through: (1) impaired drug uptake via the reduced folate carrier, (2) increased activity of the target enzymes[dihydrofolate reductase(DHFR) or thymidylate synthase(TS)] resulted from a concomitant amplification and overexpression of their gene, (3) induction of a variant DHFR with a low affinity for antifolate drug(s) used for the selection of resistance, and (4) defective polyglutamation.	Folic Acid	37-43	dihydrofolate reductase	Homo sapiens	187-191
11774738-2	2001	The cells acquired resistance to antifolate drug(s) through: (1) impaired drug uptake via the reduced folate carrier, (2) increased activity of the target enzymes[dihydrofolate reductase(DHFR) or thymidylate synthase(TS)] resulted from a concomitant amplification and overexpression of their gene, (3) induction of a variant DHFR with a low affinity for antifolate drug(s) used for the selection of resistance, and (4) defective polyglutamation.	Folic Acid	37-43	thymidylate synthetase	Homo sapiens	196-216
11520899-12	2001	Together, these findings indicate a close functional relationship between single-carbon folate metabolism and DA-stimulated PLM, consistent with a role for 5-methylTHF as the methyl donor for the D4R-mediated process.	Folic Acid	88-94	dopamine receptor D4	Homo sapiens	196-199
11389096-6	2001	Furthermore, because MTX and folic acid share metabolic pathways, we measured the effects of GGH overexpression on folic acid metabolism.	Folic Acid	115-125	gamma-glutamyl hydrolase	Homo sapiens	93-96
11386852-6	2001	Theoretically, mutated SHMT could lead to elevated Hcy levels and to an altered distribution of the different folate derivatives and might therefore become a risk factor for NTD.	Folic Acid	110-116	serine hydroxymethyltransferase 1	Homo sapiens	23-27
11386852-16	2001	Still, the influence of the 1420 C&gt;T polymorphism of the cSHMT gene on the folate-related risk of NTD needs further investigation.	Folic Acid	78-84	serine hydroxymethyltransferase 1	Homo sapiens	60-65
11274972-3	2001	Intracellular folate cofactor levels increased almost in proportion to the increase in extracellular 5-formyltetrahydrofolate (5-CHO-THF) over a concentration range that encompassed physiological levels of 5-methyltetrahydrofolate.	Folic Acid	14-20	thin fur	Mus musculus	133-136
11223131-5	2001	By means of complementation experiments using 1-carbon metabolism mutants of both Escherichia coli and Saccharomyces cerevisiae, we demonstrate here that one of these parasite genes encodes both dihydrofolate synthetase (DHFS) and folylpolyglutamate synthetase (FPGS) activities, which catalyse the synthesis and polyglutamation of folate derivatives, respectively.	Folic Acid	202-208	folylpolyglutamate synthase	Homo sapiens	262-266
11223131-8	2001	As PfDHFS--FPGS harbours two activities critical to folate metabolism, one of which has no human counterpart, this gene product offers a novel chemotherapeutic target with the potential to deliver a powerful blockage to parasite growth.	Folic Acid	52-58	folylpolyglutamate synthase	Homo sapiens	11-15
11139396-2	2001	We show that CB 3717/folate induces the expression of the hepatocyte growth factor (HGF)/c-Met signalling system in injured kidneys in which a significant, but transient, elevation of the HGF mRNA level occurs.	Folic Acid	21-27	met proto-oncogene	Mus musculus	89-94
11139396-4	2001	However, when testosterone and anti-folate/folate are administered sequentially, a substantial (3.5-4.0-fold) decrease in the increase of c-Met expression caused by CB 3717/folate alone occurs.	Folic Acid	36-42	met proto-oncogene	Mus musculus	138-143
11139396-4	2001	However, when testosterone and anti-folate/folate are administered sequentially, a substantial (3.5-4.0-fold) decrease in the increase of c-Met expression caused by CB 3717/folate alone occurs.	Folic Acid	43-49	met proto-oncogene	Mus musculus	138-143
11996001-1	2001	Dihydrofolate reductase (DHFR, EC 1.5.1.3) is one of the enzymes active in the folate cycle which plays an important role in DNA synthesis.	Folic Acid	7-13	dihydrofolate reductase	Homo sapiens	25-29
11261750-0	2001	CSF-folate levels are decreased in late-onset AD patients.	Folic Acid	4-10	colony stimulating factor 2	Homo sapiens	0-3
11261750-2	2001	Remarkably CSF-folate levels are 3 to 4 times higher than blood-folate levels.	Folic Acid	15-21	colony stimulating factor 2	Homo sapiens	11-14
11261750-3	2001	To reach the brain, folates are actively transported by choroid plexus (CP) as well as vitamins B6, B12, C and E. Epithelial atrophy having been reported in aging and in Alzheimer"s disease (AD), we measured the CSF folate-levels of 126 patients, including 30 AD consecutive patients to evaluate whether CP functions of folate-transport were impaired.	Folic Acid	20-27	ceruloplasmin	Homo sapiens	72-74
11261750-3	2001	To reach the brain, folates are actively transported by choroid plexus (CP) as well as vitamins B6, B12, C and E. Epithelial atrophy having been reported in aging and in Alzheimer"s disease (AD), we measured the CSF folate-levels of 126 patients, including 30 AD consecutive patients to evaluate whether CP functions of folate-transport were impaired.	Folic Acid	20-27	colony stimulating factor 2	Homo sapiens	212-215
11261750-3	2001	To reach the brain, folates are actively transported by choroid plexus (CP) as well as vitamins B6, B12, C and E. Epithelial atrophy having been reported in aging and in Alzheimer"s disease (AD), we measured the CSF folate-levels of 126 patients, including 30 AD consecutive patients to evaluate whether CP functions of folate-transport were impaired.	Folic Acid	20-27	ceruloplasmin	Homo sapiens	304-306
11261750-3	2001	To reach the brain, folates are actively transported by choroid plexus (CP) as well as vitamins B6, B12, C and E. Epithelial atrophy having been reported in aging and in Alzheimer"s disease (AD), we measured the CSF folate-levels of 126 patients, including 30 AD consecutive patients to evaluate whether CP functions of folate-transport were impaired.	Folic Acid	20-26	ceruloplasmin	Homo sapiens	72-74
11261750-3	2001	To reach the brain, folates are actively transported by choroid plexus (CP) as well as vitamins B6, B12, C and E. Epithelial atrophy having been reported in aging and in Alzheimer"s disease (AD), we measured the CSF folate-levels of 126 patients, including 30 AD consecutive patients to evaluate whether CP functions of folate-transport were impaired.	Folic Acid	20-26	colony stimulating factor 2	Homo sapiens	212-215
11261750-3	2001	To reach the brain, folates are actively transported by choroid plexus (CP) as well as vitamins B6, B12, C and E. Epithelial atrophy having been reported in aging and in Alzheimer"s disease (AD), we measured the CSF folate-levels of 126 patients, including 30 AD consecutive patients to evaluate whether CP functions of folate-transport were impaired.	Folic Acid	20-26	ceruloplasmin	Homo sapiens	304-306
11261750-3	2001	To reach the brain, folates are actively transported by choroid plexus (CP) as well as vitamins B6, B12, C and E. Epithelial atrophy having been reported in aging and in Alzheimer"s disease (AD), we measured the CSF folate-levels of 126 patients, including 30 AD consecutive patients to evaluate whether CP functions of folate-transport were impaired.	Folic Acid	216-222	ceruloplasmin	Homo sapiens	72-74
11261750-4	2001	CSF-folate concentrations did not vary with age (10.47 +/- 1.93ng/ml between 20 and 60 years; 9.96 +/- 2.01 ng/ml in elderly control patients older than 60 years of age, p > 0.05) while late-onset AD patients had significantly lower CSF-folate levels (8.26 +/- 1.82 ng/ml, p < 0.001).	Folic Acid	4-10	colony stimulating factor 2	Homo sapiens	0-3
10964921-1	2000	Folylpoly-gamma-glutamate synthetase (FPGS) catalyzes the activation of folate antimetabolites in mammalian tissues and tumors.	Folic Acid	72-78	folylpolyglutamate synthase	Homo sapiens	0-36
10964921-1	2000	Folylpoly-gamma-glutamate synthetase (FPGS) catalyzes the activation of folate antimetabolites in mammalian tissues and tumors.	Folic Acid	72-78	folylpolyglutamate synthase	Homo sapiens	38-42
22824165-9	2012	Male mice weaned to the folic acid deficient diet had decreased cauda sperm numbers, increased DNA fragmentation index, and increased ESTR mutation frequency.	Folic Acid	24-34	estrogen receptor 1 (alpha)	Mus musculus	134-138
22837425-6	2012	Our current findings suggest for the first time that metformin can function as an antifolate chemotherapeutic agent that induces the ATM/AMPK tumor suppressor axis secondarily following the alteration of the carbon flow through the folate-related one-carbon metabolic pathways.	Folic Acid	86-92	ATM serine/threonine kinase	Homo sapiens	133-136
22644798-2	2012	Folate receptor alpha (FRalpha), a protein-mediating cellular accumulation of folate (and anti-folates), has limited expression in normal tissues and is overexpressed by numerous carcinomas.	Folic Acid	78-84	folate receptor alpha	Homo sapiens	0-21
22644798-2	2012	Folate receptor alpha (FRalpha), a protein-mediating cellular accumulation of folate (and anti-folates), has limited expression in normal tissues and is overexpressed by numerous carcinomas.	Folic Acid	78-84	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	23-30
22644798-2	2012	Folate receptor alpha (FRalpha), a protein-mediating cellular accumulation of folate (and anti-folates), has limited expression in normal tissues and is overexpressed by numerous carcinomas.	Folic Acid	95-102	folate receptor alpha	Homo sapiens	0-21
22644798-2	2012	Folate receptor alpha (FRalpha), a protein-mediating cellular accumulation of folate (and anti-folates), has limited expression in normal tissues and is overexpressed by numerous carcinomas.	Folic Acid	95-102	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	23-30
22571483-3	2012	MTX, the monoglutamate form (MTXG1) inhibits the dihydrofolate reductase (DHFR) implicated in the folate cycle.	Folic Acid	56-62	dihydrofolate reductase	Homo sapiens	74-78
22647887-5	2012	In mice with hHcys induced by feeding them a folate-free diet, NALP3 inflammasome formation and activation in glomerular podocytes were detected at an early stage, as shown by confocal microscopy, size exclusion chromatography of the assembled inflammasome complex, and increased interleukin-1beta production in glomeruli.	Folic Acid	45-51	NLR family, pyrin domain containing 3	Mus musculus	63-68
22345511-0	2012	A P425R mutation of the proton-coupled folate transporter causing hereditary folate malabsorption produces a highly selective alteration in folate binding.	Folic Acid	77-83	solute carrier family 46 member 1	Homo sapiens	24-57
22345511-1	2012	Proton-coupled folate transporter (PCFT) mediates folate intestinal absorption and transport across the choroid plexus, processes defective in subjects with hereditary folate malabsorption (HFM).	Folic Acid	15-21	solute carrier family 46 member 1	Homo sapiens	35-39
22345511-5	2012	Transport of reduced folates mediated by P425R-PCFT was virtually abolished; the methotrexate influx K(t) was increased fivefold (from 2 to 10 muM).	Folic Acid	21-28	solute carrier family 46 member 1	Homo sapiens	47-51
22345511-10	2012	Hence, despite its location, the P425R-PCFT mutation produces a conformational change that fully preserves pemetrexed binding but markedly impairs binding of methotrexate and other folates to the carrier.	Folic Acid	181-188	solute carrier family 46 member 1	Homo sapiens	39-43
22568793-1	2012	gamma-Glutamyl hydrolase (GGH) plays a central role in folate metabolism and antifolate action.	Folic Acid	55-61	gamma-glutamyl hydrolase	Homo sapiens	0-24
22568793-1	2012	gamma-Glutamyl hydrolase (GGH) plays a central role in folate metabolism and antifolate action.	Folic Acid	55-61	gamma-glutamyl hydrolase	Homo sapiens	26-29
26105097-1	2012	The transport of folate across the placenta involves a number of different receptors including folate receptor-alpha (FR-alpha), reduced folate carrier (RFC) and proton coupled folate transporter (PCFT).	Folic Acid	17-23	folate receptor alpha	Homo sapiens	95-116
26105097-1	2012	The transport of folate across the placenta involves a number of different receptors including folate receptor-alpha (FR-alpha), reduced folate carrier (RFC) and proton coupled folate transporter (PCFT).	Folic Acid	17-23	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	118-126
26105097-1	2012	The transport of folate across the placenta involves a number of different receptors including folate receptor-alpha (FR-alpha), reduced folate carrier (RFC) and proton coupled folate transporter (PCFT).	Folic Acid	17-23	solute carrier family 46 member 1	Homo sapiens	162-195
26105097-1	2012	The transport of folate across the placenta involves a number of different receptors including folate receptor-alpha (FR-alpha), reduced folate carrier (RFC) and proton coupled folate transporter (PCFT).	Folic Acid	17-23	solute carrier family 46 member 1	Homo sapiens	197-201
26105097-10	2012	Reductions in FR-alpha and PCFT in pre-eclampsia may be a mechanism involved in the pathogenesis of pre-eclampsia by limiting placental folate uptake resulting in reduced levels of angiogenesis, cell proliferation and antioxidant protection.	Folic Acid	136-142	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	14-22
26105097-10	2012	Reductions in FR-alpha and PCFT in pre-eclampsia may be a mechanism involved in the pathogenesis of pre-eclampsia by limiting placental folate uptake resulting in reduced levels of angiogenesis, cell proliferation and antioxidant protection.	Folic Acid	136-142	solute carrier family 46 member 1	Homo sapiens	27-31
21771248-5	2012	RESULTS:   The results show that higher levels of folic acid can increase cell growth in PC-3 and LNCaP prostate cancer cell lines, and may also increase the invasive capacity of PC-3, LNCaP and DU145 cells.	Folic Acid	50-60	chromobox 8	Homo sapiens	89-93
21771248-5	2012	RESULTS:   The results show that higher levels of folic acid can increase cell growth in PC-3 and LNCaP prostate cancer cell lines, and may also increase the invasive capacity of PC-3, LNCaP and DU145 cells.	Folic Acid	50-60	chromobox 8	Homo sapiens	179-183
22649905-0	2012	AOAC SMPR 2011.006: Standard method performance requirements for folate in infant formula and adult/pediatric nutritional formula.	Folic Acid	65-71	mannose-6-phosphate receptor, cation dependent	Homo sapiens	5-9
22220685-9	2012	Finally, SHMT1 and SHMT2 expression were significantly correlated with those of other Folate and Methionine Cycle genes at both the messenger RNA and protein levels.	Folic Acid	86-92	serine hydroxymethyltransferase 1	Homo sapiens	9-14
22334042-0	2012	Folic acid enhances Notch signaling, hippocampal neurogenesis, and cognitive function in a rat model of cerebral ischemia.	Folic Acid	0-10	notch receptor 1	Rattus norvegicus	20-25
22334042-3	2012	Folic acid supplementation stimulates Notch signaling  and cell proliferation in neural progenitor cells cultured from neonatal brain.	Folic Acid	0-10	notch receptor 1	Rattus norvegicus	38-43
22334042-4	2012	The present study determined whether folic acid supplementation stimulates Notch signaling and neurogenesis and improves cognitive function after ischemic stroke in adult brain.	Folic Acid	37-47	notch receptor 1	Rattus norvegicus	75-80
22334042-12	2012	Folic acid enhances the stimulation by ischemia of Notch signaling and hippocampal neurogenesis in adult brain and lessens the impairment of cognitive function that occurs after experimental stroke.	Folic Acid	0-10	notch receptor 1	Rattus norvegicus	51-56
21707700-6	2012	RESULTS: S- and ER-folate pretreatment concentrations increased significantly with increasing number of HD MTX cycles (P &lt; 0.001).	Folic Acid	19-25	metaxin 1	Homo sapiens	107-110
22018726-1	2012	The enzymes folylpolyglutamate synthase (FPGS) and gamma-glutamyl hydrolase (GGH) are essential for determining intracellular folate availability for one-carbon metabolism (OCM) pathways.	Folic Acid	126-132	folylpolyglutamate synthase	Homo sapiens	12-39
22018726-1	2012	The enzymes folylpolyglutamate synthase (FPGS) and gamma-glutamyl hydrolase (GGH) are essential for determining intracellular folate availability for one-carbon metabolism (OCM) pathways.	Folic Acid	126-132	folylpolyglutamate synthase	Homo sapiens	41-45
22018726-1	2012	The enzymes folylpolyglutamate synthase (FPGS) and gamma-glutamyl hydrolase (GGH) are essential for determining intracellular folate availability for one-carbon metabolism (OCM) pathways.	Folic Acid	126-132	gamma-glutamyl hydrolase	Homo sapiens	51-75
22018726-1	2012	The enzymes folylpolyglutamate synthase (FPGS) and gamma-glutamyl hydrolase (GGH) are essential for determining intracellular folate availability for one-carbon metabolism (OCM) pathways.	Folic Acid	126-132	gamma-glutamyl hydrolase	Homo sapiens	77-80
22018726-2	2012	FPGS adds glutamyl groups to the folate molecule, thereby converting folate into the preferred substrate for several enzymes in OCM pathways.	Folic Acid	33-39	folylpolyglutamate synthase	Homo sapiens	0-4
22018726-2	2012	FPGS adds glutamyl groups to the folate molecule, thereby converting folate into the preferred substrate for several enzymes in OCM pathways.	Folic Acid	69-75	folylpolyglutamate synthase	Homo sapiens	0-4
22018726-3	2012	GGH removes glutamyl groups, allowing folate metabolites to leave the cell.	Folic Acid	38-44	gamma-glutamyl hydrolase	Homo sapiens	0-3
23137028-6	2012	Upregulation of DNA damage repair genes Apurinic/apyrimidinic endonuclease 1, X-ray repair complementing defective repair in Chinese hamster cells 5, 8-oxoguanine-DNA glycosylase, and proliferating cell nuclear antigen, associated with a reduction of folic acid level was observed in colons of DMH group.	Folic Acid	251-261	DNA-(apurinic or apyrimidinic site) endonuclease	Cricetulus griseus	40-76
23144806-1	2012	Despite being an essential vitamin, folate has been implicated to enhance tumor growth, as evidenced by reports on overexpression of folate receptor alpha (FRalpha) in carcinomas.	Folic Acid	36-42	folate receptor alpha	Homo sapiens	133-154
23144806-1	2012	Despite being an essential vitamin, folate has been implicated to enhance tumor growth, as evidenced by reports on overexpression of folate receptor alpha (FRalpha) in carcinomas.	Folic Acid	36-42	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	156-163
22065534-2	2011	The folate-sensitive fragile site FRAXE is located in Xq28 approximately 600 kb distal to the fragile X syndrome fragile site (FRAXA) and harbors an unstable GCC (CCG) triplet repeat adjacent to a CpG island in the 5" untranslated region of the AFF2 (FMR2) gene.	Folic Acid	4-10	fragile site, folic acid type, rare, fra(X)(q28) E	Homo sapiens	34-39
22065534-2	2011	The folate-sensitive fragile site FRAXE is located in Xq28 approximately 600 kb distal to the fragile X syndrome fragile site (FRAXA) and harbors an unstable GCC (CCG) triplet repeat adjacent to a CpG island in the 5" untranslated region of the AFF2 (FMR2) gene.	Folic Acid	4-10	AF4/FMR2 family member 2	Homo sapiens	245-249
22065534-2	2011	The folate-sensitive fragile site FRAXE is located in Xq28 approximately 600 kb distal to the fragile X syndrome fragile site (FRAXA) and harbors an unstable GCC (CCG) triplet repeat adjacent to a CpG island in the 5" untranslated region of the AFF2 (FMR2) gene.	Folic Acid	4-10	AF4/FMR2 family member 2	Homo sapiens	251-255
21649587-1	2011	Mice lacking the gene for Folr1 (folic acid receptor 1) have an NTD (neural tube defect) that is rescued by maternal folate supplementation.	Folic Acid	117-123	folate receptor 1 (adult)	Mus musculus	26-31
21649587-1	2011	Mice lacking the gene for Folr1 (folic acid receptor 1) have an NTD (neural tube defect) that is rescued by maternal folate supplementation.	Folic Acid	117-123	folate receptor 1 (adult)	Mus musculus	33-54
21730260-3	2011	We have shown previously that diabetes induces GNMT expression and reduces plasma homocysteine pools by stimulating both its catabolism and folate-independent remethylation.	Folic Acid	140-146	glycine N-methyltransferase	Rattus norvegicus	47-51
21721545-0	2011	A binary functional substrate for enrichment and ultrasensitive SERS spectroscopic detection of folic acid using graphene oxide/Ag nanoparticle hybrids.	Folic Acid	96-106	seryl-tRNA synthetase 1	Homo sapiens	64-68
21721545-2	2011	Using the obtained GO/PDDA/AgNPs as SERS substrates, an ultrasensitive and label-free detection of folic acid in water and serum was demonstrated based on the inherent SERS spectra of folic acid.	Folic Acid	99-109	seryl-tRNA synthetase 1	Homo sapiens	36-40
21721545-2	2011	Using the obtained GO/PDDA/AgNPs as SERS substrates, an ultrasensitive and label-free detection of folic acid in water and serum was demonstrated based on the inherent SERS spectra of folic acid.	Folic Acid	99-109	seryl-tRNA synthetase 1	Homo sapiens	168-172
21721545-2	2011	Using the obtained GO/PDDA/AgNPs as SERS substrates, an ultrasensitive and label-free detection of folic acid in water and serum was demonstrated based on the inherent SERS spectra of folic acid.	Folic Acid	184-194	seryl-tRNA synthetase 1	Homo sapiens	36-40
21721545-2	2011	Using the obtained GO/PDDA/AgNPs as SERS substrates, an ultrasensitive and label-free detection of folic acid in water and serum was demonstrated based on the inherent SERS spectra of folic acid.	Folic Acid	184-194	seryl-tRNA synthetase 1	Homo sapiens	168-172
21721545-3	2011	The modified graphene oxide exhibited strong enrichment of folic acid due to the electrostatic interaction, and the self-assembled Ag nanoparticles greatly enhanced the SERS spectra of folic acid, both of which led to an ultrahigh sensitivity.	Folic Acid	185-195	seryl-tRNA synthetase 1	Homo sapiens	169-173
21721545-4	2011	Therefore, although the SERS enhancement of p-ATP on GO/PDDA/AgNPs was weaker than that on Ag nanoparticles, the SERS signals of folic acid on GO/PDDA/AgNPs were much stronger than that on Ag nanoparticles.	Folic Acid	129-139	seryl-tRNA synthetase 1	Homo sapiens	24-28
21721545-4	2011	Therefore, although the SERS enhancement of p-ATP on GO/PDDA/AgNPs was weaker than that on Ag nanoparticles, the SERS signals of folic acid on GO/PDDA/AgNPs were much stronger than that on Ag nanoparticles.	Folic Acid	129-139	seryl-tRNA synthetase 1	Homo sapiens	113-117
21721545-6	2011	The SERS spectra of the folic acid showed that the minimum detected concentration of folic acid in water was as low as 9 nM with a linear response range from 9 to 180 nM.	Folic Acid	24-34	seryl-tRNA synthetase 1	Homo sapiens	4-8
21721545-6	2011	The SERS spectra of the folic acid showed that the minimum detected concentration of folic acid in water was as low as 9 nM with a linear response range from 9 to 180 nM.	Folic Acid	85-95	seryl-tRNA synthetase 1	Homo sapiens	4-8
21721545-9	2011	This ultrasensitive and label-free SERS detection of folic acid based on GO/PDDA/AgNPs offers great potential for practical applications of medicine and biotechnology.	Folic Acid	53-63	seryl-tRNA synthetase 1	Homo sapiens	35-39
21576080-0	2011	Association between inhibited binding of folic acid to folate receptor alpha in maternal serum and folate-related birth defects in Norway.	Folic Acid	41-51	folate receptor alpha	Homo sapiens	55-76
21576080-3	2011	We explored the relationship of these birth defects to inhibition of folic acid binding to folate receptor alpha (FRalpha), as well as possible effects of parental demographics or prenatal exposures.	Folic Acid	69-79	folate receptor alpha	Homo sapiens	91-112
21576080-3	2011	We explored the relationship of these birth defects to inhibition of folic acid binding to folate receptor alpha (FRalpha), as well as possible effects of parental demographics or prenatal exposures.	Folic Acid	69-79	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	114-121
21576080-6	2011	The inhibition of folic acid binding to FRalpha was measured in maternal plasma collected around 17 weeks of gestation.	Folic Acid	18-28	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	40-47
21576080-11	2011	CONCLUSIONS: Inhibition of folic acid binding to FRalpha in maternal plasma collected during pregnancy was associated with increased risk of NTDs but not oral facial clefts.	Folic Acid	27-37	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	49-56
21765609-0	2011	Relationship between dietary folate intake and plasma monocyte chemoattractant protein-1 and interleukin-8 in heart failure patients.	Folic Acid	29-35	C-C motif chemokine ligand 2	Homo sapiens	54-88
21765609-7	2011	On the other hand, plasma levels of monocyte chemoattractant protein-1 significantly correlated with dietary folate intake (r = -0.31, p&lt;0.001), and plasma interleukin-8 levels significantly correlated with dietary intakes of vitamin C (r = -0.38, p&lt;0.001), beta-carotene (r = -0.42, p&lt;0.001), and folate (r = -0.38, p&lt;0.001) after the adjustment.	Folic Acid	109-115	C-C motif chemokine ligand 2	Homo sapiens	36-70
21765609-8	2011	Dietary folate intake was found as a primary influencing factor on plasma levels of monocyte chemoattractant protein-1 (p&lt;0.005, R(2) = 0.20) and interleukin-8 (p&lt;0.001, R(2) = 0.32) through a stepwise multiple linear regression analysis.	Folic Acid	8-14	C-C motif chemokine ligand 2	Homo sapiens	84-118
21765609-9	2011	Dietary folate intake was significantly associated with plasma levels of monocyte chemoattractant protein-1 and interleukin-8 which indicates dietary folate may have a potentially beneficial role in the prevention and treatment of heart failure.	Folic Acid	8-14	C-C motif chemokine ligand 2	Homo sapiens	73-107
21765609-9	2011	Dietary folate intake was significantly associated with plasma levels of monocyte chemoattractant protein-1 and interleukin-8 which indicates dietary folate may have a potentially beneficial role in the prevention and treatment of heart failure.	Folic Acid	150-156	C-C motif chemokine ligand 2	Homo sapiens	73-107
21497120-4	2011	In the present study we show that cultured skin fibroblasts from cblC patients export increased levels of both homocysteine and methylmalonic acid compared to control skin fibroblasts, and that they also have decreased levels of total intracellular folates.	Folic Acid	249-256	Cbl proto-oncogene C	Homo sapiens	65-69
11472112-1	2001	Despite much experimental and computational study, key aspects of the mechanism of reduction of dihydrofolate (DHF) by dihydrofolate reductase (DHFR) remain unresolved, while the secondary DHFR-catalyzed reduction of folate has been little studied.	Folic Acid	103-109	Dihydrofolate reductase	Escherichia coli	119-142
11472112-1	2001	Despite much experimental and computational study, key aspects of the mechanism of reduction of dihydrofolate (DHF) by dihydrofolate reductase (DHFR) remain unresolved, while the secondary DHFR-catalyzed reduction of folate has been little studied.	Folic Acid	103-109	Dihydrofolate reductase	Escherichia coli	144-148
11472112-1	2001	Despite much experimental and computational study, key aspects of the mechanism of reduction of dihydrofolate (DHF) by dihydrofolate reductase (DHFR) remain unresolved, while the secondary DHFR-catalyzed reduction of folate has been little studied.	Folic Acid	103-109	Dihydrofolate reductase	Escherichia coli	189-193
21520493-10	2011	Folate depletion reduced Igf2 DMR1 and Slc39a4CGI1 methylation across all tissues and altered Igf2 DMR2 methylation in a tissue-specific manner (p&lt;0.05).	Folic Acid	0-6	insulin-like growth factor 2	Mus musculus	25-29
11284680-4	2001	Although the crystal structure of the complex of R67 DHFR with folate has been reported [Narayana et al.	Folic Acid	63-69	dihydrofolate reductase	Homo sapiens	53-57
11284680-19	2001	Analogous NMR studies performed on folate, DMDDF, and R67 DHFR indicate formation of a ternary complex in which two symmetry-related binding sites are occupied by folate and DMDDF.	Folic Acid	163-169	dihydrofolate reductase	Homo sapiens	58-62
21520493-10	2011	Folate depletion reduced Igf2 DMR1 and Slc39a4CGI1 methylation across all tissues and altered Igf2 DMR2 methylation in a tissue-specific manner (p&lt;0.05).	Folic Acid	0-6	insulin-like growth factor 2	Mus musculus	94-98
21557375-8	2011	Additionally, the anti-MTX VHH possessed relatively high specificity for MTX over closely related compounds aminopterin and folate, demonstrating that VHH domains are capable of binding low-molecular weight ligands with high affinity and specificity, despite their reduced interface.	Folic Acid	124-130	metaxin 1	Homo sapiens	23-26
11962509-0	2001	Investigations on the biological properties of the lipophilic DHFR-inhibitory benzoprims reveal non-folate modes of action and opportunities for anti-cancer drug design.	Folic Acid	100-106	dihydrofolate reductase	Homo sapiens	62-66
21557375-8	2011	Additionally, the anti-MTX VHH possessed relatively high specificity for MTX over closely related compounds aminopterin and folate, demonstrating that VHH domains are capable of binding low-molecular weight ligands with high affinity and specificity, despite their reduced interface.	Folic Acid	124-130	metaxin 1	Homo sapiens	73-76
21781484-6	2011	The results in our study indicated that there was an additive interaction between low-level of serum folate and high-expression of DNMT1 protein related to the risk of CIN and SCC, with OR value as 2.50 (95%CI: 1.21 - 9.22) and 6.03 (95%CI: 2.79 - 21.72) respectively.	Folic Acid	101-107	serpin family B member 3	Homo sapiens	176-179
11509884-2	2001	Among them, dihydrofolate reductase (DHFR) and thymidylate synthase (TS) require folate as coenzymes.	Folic Acid	19-25	dihydrofolate reductase	Homo sapiens	37-41
11509884-2	2001	Among them, dihydrofolate reductase (DHFR) and thymidylate synthase (TS) require folate as coenzymes.	Folic Acid	19-25	thymidylate synthetase	Homo sapiens	47-67
11509884-2	2001	Among them, dihydrofolate reductase (DHFR) and thymidylate synthase (TS) require folate as coenzymes.	Folic Acid	19-25	thymidylate synthetase	Homo sapiens	69-71
11509884-3	2001	In growing cells, folates are readily converted to polyglutamated forms by the cellular enzyme folylpolyglutamate synthetase (FPGS).	Folic Acid	18-25	folylpolyglutamate synthase	Homo sapiens	95-124
11509884-3	2001	In growing cells, folates are readily converted to polyglutamated forms by the cellular enzyme folylpolyglutamate synthetase (FPGS).	Folic Acid	18-25	folylpolyglutamate synthase	Homo sapiens	126-130
11509884-4	2001	Polyglutamated folates are selectively retained within the cell and have an increased affinity for DHFR and TS.	Folic Acid	15-22	dihydrofolate reductase	Homo sapiens	99-103
11509884-4	2001	Polyglutamated folates are selectively retained within the cell and have an increased affinity for DHFR and TS.	Folic Acid	15-22	thymidylate synthetase	Homo sapiens	108-110
11509884-6	2001	FPGS induction by MCMV would provide the necessary supply of polyglutamated folates to the cellular enzymes involved in the biosynthesis of deoxyribonucleotides, enabling viral DNA replication to take place in quiescent cells.	Folic Acid	76-83	folylpolyglutamate synthase	Homo sapiens	0-4
11524555-2	2001	Pemetrexed inhibits multiple folate-dependent enzymes involved in both purine and pyrimidine synthesis including thymidylate synthase, dihydrofolate reductase, glycinamide ribonucleotide formyltransferase, and aminoimidazole carboxamide ribonucleotide formyltransferase.	Folic Acid	29-35	thymidylate synthetase	Homo sapiens	113-133
10980581-1	2000	The human 5,10-methylenetetrahydrofolate reductase (MTHFR) represents a major enzyme in the folate-dependent regulation of methionine and homocysteine concentrations.	Folic Acid	34-40	methylenetetrahydrofolate reductase	Homo sapiens	52-57
10648641-1	2000	In previous reports, an E45K mutation in reduced folate carrier (RFC1) resulted in marked substrate-specific changes in folate binding and the induction of an obligatory inorganic anion requirement for carrier function.	Folic Acid	49-55	replication factor C subunit 1	Homo sapiens	65-69
10648641-1	2000	In previous reports, an E45K mutation in reduced folate carrier (RFC1) resulted in marked substrate-specific changes in folate binding and the induction of an obligatory inorganic anion requirement for carrier function.	Folic Acid	120-126	replication factor C subunit 1	Homo sapiens	65-69
10648641-7	2000	These data further substantiate the important role that glutamate-45 plays in the selectivity of binding of folates to RFC1 and establish that it is the addition of a positive charge at this site and not the loss of a negative charge that results in the induced anion dependence.	Folic Acid	108-115	replication factor C subunit 1	Homo sapiens	119-123
10648641-8	2000	These and other studies indicate that mutations in the first transmembrane domain can have a markedly selective impact on the affinity of RFC1 for folate compounds and in particularly a highly salutary effect on binding of the oxidized folate, folic acid.	Folic Acid	147-153	replication factor C subunit 1	Homo sapiens	138-142
11214939-3	2000	The underlying basis is a derangement of homocysteine metabolism due to a missense mutation of the MTHFR enzyme that has to catalyze the folate metabolic cycle furnishing sufficient methyl groups for DNA and tRNA synthesis.	Folic Acid	137-143	methylenetetrahydrofolate reductase	Homo sapiens	99-104
11214939-4	2000	Folate can overcome the dysfunction of the mutation and the decreased activity of the thermolabile MTHFR.	Folic Acid	0-6	methylenetetrahydrofolate reductase	Homo sapiens	99-104
10695265-0	2000	The relation between erythrocyte volume and folate levels is influenced by a common mutation in the methylenetetrahydrofolate reductase (MTHFR) gene (C677T).	Folic Acid	44-50	methylenetetrahydrofolate reductase	Homo sapiens	100-135
10695265-0	2000	The relation between erythrocyte volume and folate levels is influenced by a common mutation in the methylenetetrahydrofolate reductase (MTHFR) gene (C677T).	Folic Acid	44-50	methylenetetrahydrofolate reductase	Homo sapiens	137-142
10695265-1	2000	BACKGROUND: The enzyme 5,10 methylenetetrahydrofolate reductase (MTHFR) plays an important role in folate metabolism and folate-dependent reactions.	Folic Acid	47-53	methylenetetrahydrofolate reductase	Homo sapiens	65-70
10695265-1	2000	BACKGROUND: The enzyme 5,10 methylenetetrahydrofolate reductase (MTHFR) plays an important role in folate metabolism and folate-dependent reactions.	Folic Acid	99-105	methylenetetrahydrofolate reductase	Homo sapiens	28-63
10695265-1	2000	BACKGROUND: The enzyme 5,10 methylenetetrahydrofolate reductase (MTHFR) plays an important role in folate metabolism and folate-dependent reactions.	Folic Acid	99-105	methylenetetrahydrofolate reductase	Homo sapiens	65-70
10695265-2	2000	Homozygosity for a common polymorphism in the MTHFR gene (C677T, Ala to Val) is associated with an increased risk of neural tube defects and hyperhomocysteinemia in individuals with low folate levels.	Folic Acid	186-192	methylenetetrahydrofolate reductase	Homo sapiens	46-51
10537295-11	1999	The results of these analyses suggest that the protective effect of folate in colon cancer observed in published studies may be mediated through folate"s effect on Ki-ras mutations.	Folic Acid	68-74	KRAS proto-oncogene, GTPase	Homo sapiens	164-170
10537295-11	1999	The results of these analyses suggest that the protective effect of folate in colon cancer observed in published studies may be mediated through folate"s effect on Ki-ras mutations.	Folic Acid	145-151	KRAS proto-oncogene, GTPase	Homo sapiens	164-170
10500018-9	1999	CONCLUSION: The results of this initial study indicate that folate metabolism is abnormal in mothers of children with Down syndrome and that this may be explained, in part, by a mutation in the MTHFR gene.	Folic Acid	60-66	methylenetetrahydrofolate reductase	Homo sapiens	194-199
10440833-1	1999	Folic acid can prevent neural tube defects; in some cases the mechanism is probably a correction of a metabolic defect caused by thermolabile methylenetetrahydrofolate reductase (MTHFR) found in increased frequency in cases.	Folic Acid	0-10	methylenetetrahydrofolate reductase	Homo sapiens	142-177
10440833-1	1999	Folic acid can prevent neural tube defects; in some cases the mechanism is probably a correction of a metabolic defect caused by thermolabile methylenetetrahydrofolate reductase (MTHFR) found in increased frequency in cases.	Folic Acid	0-10	methylenetetrahydrofolate reductase	Homo sapiens	179-184
10440833-8	1999	In the Irish population homozygosity for the common folate-related polymorphism associated with thermolabile MTHFR is significantly more frequent in those with isolated cleft palate, and could be etiologically important.	Folic Acid	52-58	methylenetetrahydrofolate reductase	Homo sapiens	109-114
10498402-0	1999	A polymorphism of the methionine synthase gene: association with plasma folate, vitamin B12, homocyst(e)ine, and colorectal cancer risk.	Folic Acid	72-78	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	22-41
10498402-2	1999	In this study, we examined the relationship of a polymorphism (2756A--&gt;G, asp--&gt;gly) in the gene (MTR) for methionine synthase, another important enzyme in the same folate/methionine/homocyst(e)ine metabolic pathway, with risk of colorectal cancer among 356 cases and 476 cancer-free controls.	Folic Acid	171-177	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	113-132
10505780-3	1999	Important diet-gene interactions may exist, as illustrated by differential responses to variation in folate status in those with methylenetetrahydrofolate reductase polymorphisms.	Folic Acid	101-107	methylenetetrahydrofolate reductase	Homo sapiens	129-164
10460200-3	1999	In the current study, we determined the prevalence of a newly described mutation in the human MTHFR gene A1298C, and the already known C677T mutation, and related them to plasma total homocysteine and folate concentrations.	Folic Acid	201-207	methylenetetrahydrofolate reductase	Homo sapiens	94-99
10430972-1	1999	The purpose of this study is to observe the influence of the methylenetetrahydrofolate reductase (MTHFR) gene (677C--&gt;T substitution) on plasma homocysteine levels in end-stage renal disease (ESRD) patients who received a relatively large amount of folate (2 mg/d) and are undergoing hemodialysis.	Folic Acid	80-86	methylenetetrahydrofolate reductase	Homo sapiens	98-103
10459572-2	1999	To determine whether a common methylenetetrahydrofolate reductase (MTHFR) variant is related to elevated homocysteine concentrations in epileptic patients receiving anticonvulsants, we investigated the plasma total homocysteine (tHcy) level, folate level, and MTHFR 677 C --&gt; T mutation using a polymerase chain reaction (PCR) and restriction fragment length polymorphism analysis with HinfI digestion in 103 patients with epilepsy and 103 normal controls.	Folic Acid	49-55	methylenetetrahydrofolate reductase	Homo sapiens	67-72
10459572-4	1999	The homozygosity for the 677 C --&gt; T mutation of MTHFR was associated with elevated tHcy and low folate levels.	Folic Acid	100-106	methylenetetrahydrofolate reductase	Homo sapiens	52-57
10100295-6	1999	Homocysteine levels should be measured in patients with chronic renal failure, since simple and safe treatment with folic acid and vitamin B12 is effective in lowering the plasma homocysteine level in patients with the thermolabile MTHFR allele.	Folic Acid	116-126	methylenetetrahydrofolate reductase	Homo sapiens	232-237
9930566-8	1999	Inborn errors of folate metabolism are rare, but polymorphisms affecting the gene for methylenetetrahydrofolate reductase (MTHFR) are common and may have significant health implications.	Folic Acid	17-23	methylenetetrahydrofolate reductase	Homo sapiens	86-121
9930566-8	1999	Inborn errors of folate metabolism are rare, but polymorphisms affecting the gene for methylenetetrahydrofolate reductase (MTHFR) are common and may have significant health implications.	Folic Acid	17-23	methylenetetrahydrofolate reductase	Homo sapiens	123-128
9843457-2	1998	Recently, a mutation (677C--&gt;T) was identified in the methylenetetrahydrofolate reductase (MTHFR) gene that results in reduced folate-dependent enzyme activity and reduced remethylation of homocysteine to methionine.	Folic Acid	76-82	methylenetetrahydrofolate reductase	Homo sapiens	94-99
9870206-6	1998	These data suggest that the 677C-T MTHFR polymorphism is not a major determinant of the vascular disease but contributes to increased plasma homocysteine concentration in conjunction with low plasma folate levels.	Folic Acid	199-205	methylenetetrahydrofolate reductase	Homo sapiens	35-40
19094252-5	1998	In particular, folate is required for methylene reductase, pyridoxal phosphate for cystathionine synthase and cobalamin for methionine synthase.	Folic Acid	15-21	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	124-143
9843036-2	1998	Because of MTHFR"s involvement with folate metabolism and evidence that maternal use of a multivitamin with folic acid in early pregnancy reduces risk for cleft lip with or without cleft palate (CLP), we hypothesized that infants homozygous for the C677T genotype would be at increased risk for CLP because of lower MTHFR enzymatic activity.	Folic Acid	36-42	methylenetetrahydrofolate reductase	Homo sapiens	11-16
9843036-2	1998	Because of MTHFR"s involvement with folate metabolism and evidence that maternal use of a multivitamin with folic acid in early pregnancy reduces risk for cleft lip with or without cleft palate (CLP), we hypothesized that infants homozygous for the C677T genotype would be at increased risk for CLP because of lower MTHFR enzymatic activity.	Folic Acid	108-118	methylenetetrahydrofolate reductase	Homo sapiens	316-321
9827570-2	1998	Uptake of p-aminohippurate (PAH) by the oocytes expressing OAT1 was markedly inhibited by glutarate, alpha-ketoglutarate and probenecid, moderately inhibited by folate and methotrexate, but not inhibited by taurocholate or tetraethylammonium.	Folic Acid	161-167	solute carrier family 22 member 6	Rattus norvegicus	59-63
9827570-3	1998	Methotrexate and folate were transported by OAT1, but probenecid, a typical inhibitor of organic anion transporter, was not transported.	Folic Acid	17-23	solute carrier family 22 member 6	Rattus norvegicus	44-48
9863549-12	1998	In addition, the MTHFR genotype seems important for the inverse relationship between homocysteine and folate and vitamin B12 levels.	Folic Acid	102-108	methylenetetrahydrofolate reductase	Homo sapiens	17-22
9863549-15	1998	Moreover, the plasma level of folate, which by itself influences homocysteine levels, is also dependent on the MTHFR genotype.	Folic Acid	30-36	methylenetetrahydrofolate reductase	Homo sapiens	111-116
9826223-4	1998	MTHFR activity seems to be dependent on folate status, as shown by a lower activity in folate-deficient subjects and a return to normal values after supplementation with folic acid, and also by a decreased enzymatic activity on phytohemagglutinin (PHA)-stimulated lymphocytes grown in a folic acid-deficient medium.	Folic Acid	40-46	methylenetetrahydrofolate reductase	Homo sapiens	0-5
9826223-4	1998	MTHFR activity seems to be dependent on folate status, as shown by a lower activity in folate-deficient subjects and a return to normal values after supplementation with folic acid, and also by a decreased enzymatic activity on phytohemagglutinin (PHA)-stimulated lymphocytes grown in a folic acid-deficient medium.	Folic Acid	87-93	methylenetetrahydrofolate reductase	Homo sapiens	0-5
9826223-4	1998	MTHFR activity seems to be dependent on folate status, as shown by a lower activity in folate-deficient subjects and a return to normal values after supplementation with folic acid, and also by a decreased enzymatic activity on phytohemagglutinin (PHA)-stimulated lymphocytes grown in a folic acid-deficient medium.	Folic Acid	170-180	methylenetetrahydrofolate reductase	Homo sapiens	0-5
9826223-4	1998	MTHFR activity seems to be dependent on folate status, as shown by a lower activity in folate-deficient subjects and a return to normal values after supplementation with folic acid, and also by a decreased enzymatic activity on phytohemagglutinin (PHA)-stimulated lymphocytes grown in a folic acid-deficient medium.	Folic Acid	287-297	methylenetetrahydrofolate reductase	Homo sapiens	0-5
9789068-5	1998	Existence of formylated folates in RBCs only from individuals with the thermolabile MTHFR is consistent with the hypothesis that there is in vivo impairment in the activity of the thermolabile variant of MTHFR and that this impairment results in an altered distribution of RBC folates.	Folic Acid	24-31	methylenetetrahydrofolate reductase	Homo sapiens	84-89
9789068-5	1998	Existence of formylated folates in RBCs only from individuals with the thermolabile MTHFR is consistent with the hypothesis that there is in vivo impairment in the activity of the thermolabile variant of MTHFR and that this impairment results in an altered distribution of RBC folates.	Folic Acid	24-31	methylenetetrahydrofolate reductase	Homo sapiens	204-209
9756510-0	1998	Reduced folate derivatives are endogenous substrates for cMOAT in rats.	Folic Acid	8-14	ATP binding cassette subfamily C member 2	Rattus norvegicus	57-62
9756510-1	1998	We examined the role of the canalicular multispecific organic anion transporter (cMOAT) in the biliary excretion of reduced folate derivatives in vivo and in vitro using normal [Sprague-Dawley rats (SDR)] and mutant [Eisai hyperbilirubinemic rats (EHBR)] rats whose cMOAT is hereditarily deficient.	Folic Acid	124-130	ATP binding cassette subfamily C member 2	Rattus norvegicus	28-79
9756510-1	1998	We examined the role of the canalicular multispecific organic anion transporter (cMOAT) in the biliary excretion of reduced folate derivatives in vivo and in vitro using normal [Sprague-Dawley rats (SDR)] and mutant [Eisai hyperbilirubinemic rats (EHBR)] rats whose cMOAT is hereditarily deficient.	Folic Acid	124-130	ATP binding cassette subfamily C member 2	Rattus norvegicus	81-86
9756510-9	1998	Therefore, reduced folate derivatives are the first endogenous substrates for cMOAT that do not contain glutathione, glucuronide, or sulfate moieties.	Folic Acid	19-25	ATP binding cassette subfamily C member 2	Rattus norvegicus	78-83
9634005-0	1998	Concentrating capacity of the human reduced folate carrier (hRFC1) in human ZR-75 breast cancer cell lines.	Folic Acid	44-50	replication factor C subunit 1	Homo sapiens	60-65
9634005-8	1998	The changes in the human cells transfected with hRFC1 however, were similar to what has been observed by other investigators when RFC1 expression is increased by low folate selective pressure.	Folic Acid	166-172	replication factor C subunit 1	Homo sapiens	48-53
9634005-8	1998	The changes in the human cells transfected with hRFC1 however, were similar to what has been observed by other investigators when RFC1 expression is increased by low folate selective pressure.	Folic Acid	166-172	replication factor C subunit 1	Homo sapiens	49-53
9545395-10	1998	These data suggest that the combined heterozygosity for the two MTHFR common mutations accounts for a proportion of folate-related NTDs, which is not explained by homozygosity for the 677(C-->T) mutation, and can be an additional genetic risk factor for NTDs.	Folic Acid	116-122	methylenetetrahydrofolate reductase	Homo sapiens	64-69
9781030-2	1998	MTHFR is a key enzyme in folate-dependent remethylation of homocysteine, and reduces 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate.	Folic Acid	25-31	methylenetetrahydrofolate reductase	Homo sapiens	0-5
9586996-1	1998	Dihydroneopterin aldolase catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin during the de novo synthesis of folic acid from guanosine triphosphate.	Folic Acid	144-154	AT695_RS00200	Staphylococcus aureus	0-25
10226652-1	1998	The reduced folate carrier (rfc1) gene encodes a protein that is involved in the intracellular accumulation of folates.	Folic Acid	111-118	replication factor C subunit 1	Homo sapiens	28-32
9502330-2	1998	Because elevated homocysteine has been shown to be a possible graded risk factor for CHD, sufficient folate intake may be important in the prevention of CHD.	Folic Acid	101-107	choline dehydrogenase	Homo sapiens	85-88
9502330-2	1998	Because elevated homocysteine has been shown to be a possible graded risk factor for CHD, sufficient folate intake may be important in the prevention of CHD.	Folic Acid	101-107	choline dehydrogenase	Homo sapiens	153-156
9502330-3	1998	The magnitude of the association between folate and CHD is consistent with its effects on homocysteine.	Folic Acid	41-47	choline dehydrogenase	Homo sapiens	52-55
9154971-0	1997	Folate-based inhibitors of thymidylate synthase: synthesis and antitumor activity of gamma-linked sterically hindered dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583).	Folic Acid	0-6	thymidylate synthase	Mus musculus	27-47
9177466-0	1997	Markedly induced asialoGM1+CD8+ T cell production and enhancement of antimetastatic activity by interferon beta with folic or folinic acid.	Folic Acid	117-122	interferon beta 1, fibroblast	Mus musculus	96-111
9177466-1	1997	Either folic or folinic acid enhanced the antimetastatic activity of recombinant murine interferon beta (rMulFN beta) toward highly metastatic colon carcinoma 26 (Co 26Lu).	Folic Acid	7-12	interferon beta 1, fibroblast	Mus musculus	88-103
9054967-3	1997	In order to explore the structural role of Tyr98 in TMP-resistance the ternary complexes of the chromosomal S. aureus DHFR (SaDHFR) with methotrexate (MTX) and TMP in the presence of nicotinamide adenine dinucleotide phosphate (NADPH) as well as that of mutant Phe98Tyr DHFR SaDHFR(F98Y) ternary folate-NADPH complex have been determined by X-ray crystallography.	Folic Acid	296-302	Dihydrofolate reductase	Staphylococcus aureus	118-122
8989110-8	1996	In the vascular disease subjects, despite significantly lower folate levels in MTHFR homozygotes, there was no significant difference in homocysteine levels among the MTHFR genotype groups.	Folic Acid	62-68	methylenetetrahydrofolate reductase	Homo sapiens	79-84
8989110-9	1996	The negative slope of the regression line relating homocysteine and folate was significantly steeper for those with a homozygous MTHFR mutation compared with those without this mutation.	Folic Acid	68-74	methylenetetrahydrofolate reductase	Homo sapiens	129-134
8989110-11	1996	Because MTHFR homozygotes have increased homocysteine with low folate levels, this mutation may contribute to early-onset or familial vascular disease.	Folic Acid	63-69	methylenetetrahydrofolate reductase	Homo sapiens	8-13
8968737-0	1996	Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders.	Folic Acid	121-127	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	6-25
8826441-1	1996	Persons with a thermolabile form of the enzyme 5,10 methylenetetrahydrofolate reductase (MTHFR) have reduced enzyme activity and increased plasma homocysteine which can be lowered by supplemental folic acid.	Folic Acid	196-206	methylenetetrahydrofolate reductase	Homo sapiens	89-94
8826441-5	1996	These preliminary data suggest that the 677C--&gt;T polymorphism of the MTHFR gene is a risk factor for spina bifida and anencephaly that may provide a partial biologic explanation for why folic acid prevents these types of NTD.	Folic Acid	189-199	methylenetetrahydrofolate reductase	Homo sapiens	72-77
8664315-7	1996	The expressed folate uptake in the cRNA injected oocyte was (1) 4,4"-diisothiocyanatosilbene-2,2"-disulfonic acid (DIDS)-sensitive; and (2) saturable with an apparent Km of 1.99 +/- 0.32 micrometers and a V(max) of 3782 +/- 188 fmol/oocyte per h. The distribution of mRNA species complementary to IFC1(RFC1) in different mouse tissues was examined by Northern blot analysis.	Folic Acid	14-20	solute carrier family 19 (folate transporter), member 1	Mus musculus	297-301
8815749-0	1996	Homogeneous bioluminescence competitive binding assay for folate based on a coupled glucose-6-phosphate dehydrogenase--bacterial luciferase enzyme system.	Folic Acid	58-64	glucose-6-phosphate dehydrogenase	Homo sapiens	84-117
8815749-1	1996	A homogeneous bioluminescence competitive binding assay for folate was developed by using a coupled enzyme system of glucose-6-phosphate dehydrogenase (G6PDH) and bacterial luciferase.	Folic Acid	60-66	glucose-6-phosphate dehydrogenase	Homo sapiens	117-150
8815749-1	1996	A homogeneous bioluminescence competitive binding assay for folate was developed by using a coupled enzyme system of glucose-6-phosphate dehydrogenase (G6PDH) and bacterial luciferase.	Folic Acid	60-66	glucose-6-phosphate dehydrogenase	Homo sapiens	152-157
8815749-4	1996	In the presence of folate, there is a competition between folate and the G6PDH-folate conjugate for the binding site of the folate binding protein, and the activity of the conjugate is recovered.	Folic Acid	19-25	glucose-6-phosphate dehydrogenase	Homo sapiens	73-78
8815749-5	1996	Thus, the concentration of folate can be related to the activity of the G6PDH-folate conjugate, which is directly related to the bioluminescence produced by the coupled enzyme reaction.	Folic Acid	27-33	glucose-6-phosphate dehydrogenase	Homo sapiens	72-77
8815749-6	1996	Using this assay, dose-response curves with a detection limit of 2.5 x 10(-8) M folate were obtained, which is an improvement of an order of magnitude with respect to an assay that monitors G6PDH activity spectrophotometrically.	Folic Acid	80-86	glucose-6-phosphate dehydrogenase	Homo sapiens	190-195
8673085-1	1996	Five folate-sensitive fragile sites have been characterized at the molecular level (FRAXA, FRAXE, FRAXF, FRA16A and FRA11B).	Folic Acid	5-11	transmembrane protein 185A	Homo sapiens	98-103
8598561-10	1996	If methionine synthase is the critical enzyme, it would raise the interesting public health issue that vitamin B-12 might be able to stimulate the abnormal enzyme as folic acid does.	Folic Acid	166-176	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	3-22
8904527-4	1996	Methionine synthase converts cellular homocysteine to methionine and is a major enzyme in the biosynthetic pathways for folates, S-adenosylmethionine and biological methylations, sulphur amino acids and polyamines.	Folic Acid	120-127	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	0-19
7647779-3	1995	5, 10-Methylenetetrahydrofolate reductase (MTHFR) catalyzes the reduction of 5, 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, the predominant circulatory form of folate and carbon donor for the re-methylation of homocysteine to methionine.	Folic Acid	25-31	methylenetetrahydrofolate reductase	Homo sapiens	43-48
7702640-2	1995	ICI D1964 and CB3717 are folate-based inhibitors of thymidylate synthase (TS).	Folic Acid	25-31	thymidylate synthase	Mus musculus	52-72
7728929-5	1995	These findings suggest that the alpha-carboxyl group plays an important role in effective uptake via the reduced folate carrier, and a novel DHFR inhibitor could be obtained by chemically modifying the gamma-carboxyl moiety while leaving the alpha-carboxyl group intact.	Folic Acid	113-119	dihydrofolate reductase	Mus musculus	141-145
7741859-3	1995	We considered whether homocysteine metabolism via the enzyme methionine synthase, which requires both folate and B12, could be the critical defect in folate-related neural tube defects.	Folic Acid	102-108	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	61-80
7922267-0	1994	Differential expression of c-jun, c-fos and hsp 70 mRNAs after folic acid and ischemia-reperfusion injury: effect of antioxidant treatment.	Folic Acid	63-73	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	27-32
7922267-0	1994	Differential expression of c-jun, c-fos and hsp 70 mRNAs after folic acid and ischemia-reperfusion injury: effect of antioxidant treatment.	Folic Acid	63-73	heat shock protein family A (Hsp70) member 4	Homo sapiens	44-50
7922267-4	1994	Folic acid treatment increased c-fos and hsp70 mRNAs at 2 h, while c-jun accumulated at 1 h, although to a lesser extent.	Folic Acid	0-10	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	31-36
7922267-4	1994	Folic acid treatment increased c-fos and hsp70 mRNAs at 2 h, while c-jun accumulated at 1 h, although to a lesser extent.	Folic Acid	0-10	heat shock protein family A (Hsp70) member 4	Homo sapiens	41-46
8242637-7	1993	The FBP-transfected NIH/3T3 cells bound folic acid and internalized about 30-fold more folic acid than mock-transfected cells.	Folic Acid	40-50	far upstream element (FUSE) binding protein 1	Mus musculus	4-7
8242637-7	1993	The FBP-transfected NIH/3T3 cells bound folic acid and internalized about 30-fold more folic acid than mock-transfected cells.	Folic Acid	87-97	far upstream element (FUSE) binding protein 1	Mus musculus	4-7
8242637-8	1993	Growth analysis revealed that FBP-transfected NIH/3T3 cells like IGROV1 maintained their growth rate after 10 days of culture in medium containing physiological or low folate concentration, and tumors arising after transplanting FBP-tNIH/3T3 cells in nude mice were 3-fold heavier than those arising after transplantation of non-FBP-expressing NIH/3T3 cells.	Folic Acid	168-174	far upstream element (FUSE) binding protein 1	Mus musculus	30-33
8445646-2	1993	The primary structures of the human KB cell (FR-KB1) folate receptor (FR) and of a human placental (FR-P2) FR, proteins important in cellular accumulation of folates, have been deduced from cDNA sequences.	Folic Acid	158-165	integrin subunit alpha 3	Homo sapiens	100-105
1419906-9	1992	The stable induction of c-jun mRNA in keratinocytes at the PGA state is unique because the induction of this gene is usually transient.	Folic Acid	59-62	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	24-29
1419906-10	1992	The finding that c-fos is not coinduced suggests that c-Jun homodimers or other AP-1 heterodimers may be formed at the PGA state to facilitate the stable induction of c-jun mRNA.	Folic Acid	119-122	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	54-59
1419906-10	1992	The finding that c-fos is not coinduced suggests that c-Jun homodimers or other AP-1 heterodimers may be formed at the PGA state to facilitate the stable induction of c-jun mRNA.	Folic Acid	119-122	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	167-172
1602376-4	1992	When cultured in a standard medium with high content (2.3 microM) of folic acid, the methionine synthase of all cell types was inactivated at an initial rate of 0.05 to 0.14 h-1.	Folic Acid	69-79	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	85-104
1551827-0	1992	The mtrAB operon of Bacillus subtilis encodes GTP cyclohydrolase I (MtrA), an enzyme involved in folic acid biosynthesis, and MtrB, a regulator of tryptophan biosynthesis.	Folic Acid	97-107	GTP cyclohydrolase 1	Rattus norvegicus	46-66
1551827-1	1992	mtrA of Bacillus subtilis was shown to be the structural gene for GTP cyclohydrolase I, an enzyme essential for folic acid biosynthesis.	Folic Acid	112-122	GTP cyclohydrolase 1	Rattus norvegicus	66-86
1533575-4	1992	The increase of the mFBP expression, besides ensuring the growth of resistant cells by its contribution to the reduced folate intake, also participates in the methotrexate resistance by the internalization of folate cofactor which would compete with methotrexate hindering the effective inhibition of dihydrofolate reductase by the antifolate.	Folic Acid	119-125	far upstream element (FUSE) binding protein 1	Mus musculus	20-24
1533575-4	1992	The increase of the mFBP expression, besides ensuring the growth of resistant cells by its contribution to the reduced folate intake, also participates in the methotrexate resistance by the internalization of folate cofactor which would compete with methotrexate hindering the effective inhibition of dihydrofolate reductase by the antifolate.	Folic Acid	119-125	dihydrofolate reductase	Mus musculus	301-324
1734087-14	1992	CONCLUSION: These findings suggest that folate replacement due to administration of leucovorin modulated MTX toxicity and/or modified an interaction among VP-16, ARA-C, intrathecal therapy, and the central nervous system.	Folic Acid	40-46	host cell factor C1	Homo sapiens	155-160
1997179-5	1991	The remaining efflux of this folate analogue in ATP-replete cells appears to be mediated by the one-carbon, reduced folate system (MTX influx route), in that it is not inhibited by bromosulfophthalein or verapamil but is inhibited by the N-hydroxysuccinimide ester of MTX, a specific inhibitor of MTX influx, and a 10-fold higher concentration of probenecid than that required to inhibit ATP-dependent efflux.	Folic Acid	29-35	metaxin 1	Mus musculus	131-134
1997179-5	1991	The remaining efflux of this folate analogue in ATP-replete cells appears to be mediated by the one-carbon, reduced folate system (MTX influx route), in that it is not inhibited by bromosulfophthalein or verapamil but is inhibited by the N-hydroxysuccinimide ester of MTX, a specific inhibitor of MTX influx, and a 10-fold higher concentration of probenecid than that required to inhibit ATP-dependent efflux.	Folic Acid	29-35	metaxin 1	Mus musculus	268-271
1997179-5	1991	The remaining efflux of this folate analogue in ATP-replete cells appears to be mediated by the one-carbon, reduced folate system (MTX influx route), in that it is not inhibited by bromosulfophthalein or verapamil but is inhibited by the N-hydroxysuccinimide ester of MTX, a specific inhibitor of MTX influx, and a 10-fold higher concentration of probenecid than that required to inhibit ATP-dependent efflux.	Folic Acid	29-35	metaxin 1	Mus musculus	268-271
1997179-5	1991	The remaining efflux of this folate analogue in ATP-replete cells appears to be mediated by the one-carbon, reduced folate system (MTX influx route), in that it is not inhibited by bromosulfophthalein or verapamil but is inhibited by the N-hydroxysuccinimide ester of MTX, a specific inhibitor of MTX influx, and a 10-fold higher concentration of probenecid than that required to inhibit ATP-dependent efflux.	Folic Acid	116-122	metaxin 1	Mus musculus	131-134
2060081-3	1991	These routes include the classic reduced folate carrier and a membrane-associated folate-binding protein (mFBP).	Folic Acid	41-47	far upstream element (FUSE) binding protein 1	Mus musculus	106-110
2060081-4	1991	The role of an mFBP in the uptake of DDATHF was suggested from observations that (a) the mFBP showed a very high binding affinity for DDATHF, (b) murine and human leukemia cells expressing an mFBP were highly sensitive to growth inhibition by DDATHF, and (c) protection against this growth inhibition could be achieved using folic acid rather than reduced folate compounds.	Folic Acid	325-335	far upstream element (FUSE) binding protein 1	Mus musculus	15-19
2060081-4	1991	The role of an mFBP in the uptake of DDATHF was suggested from observations that (a) the mFBP showed a very high binding affinity for DDATHF, (b) murine and human leukemia cells expressing an mFBP were highly sensitive to growth inhibition by DDATHF, and (c) protection against this growth inhibition could be achieved using folic acid rather than reduced folate compounds.	Folic Acid	325-335	far upstream element (FUSE) binding protein 1	Mus musculus	89-93
2060081-4	1991	The role of an mFBP in the uptake of DDATHF was suggested from observations that (a) the mFBP showed a very high binding affinity for DDATHF, (b) murine and human leukemia cells expressing an mFBP were highly sensitive to growth inhibition by DDATHF, and (c) protection against this growth inhibition could be achieved using folic acid rather than reduced folate compounds.	Folic Acid	325-335	far upstream element (FUSE) binding protein 1	Mus musculus	89-93
2060081-4	1991	The role of an mFBP in the uptake of DDATHF was suggested from observations that (a) the mFBP showed a very high binding affinity for DDATHF, (b) murine and human leukemia cells expressing an mFBP were highly sensitive to growth inhibition by DDATHF, and (c) protection against this growth inhibition could be achieved using folic acid rather than reduced folate compounds.	Folic Acid	356-362	far upstream element (FUSE) binding protein 1	Mus musculus	15-19
2060081-4	1991	The role of an mFBP in the uptake of DDATHF was suggested from observations that (a) the mFBP showed a very high binding affinity for DDATHF, (b) murine and human leukemia cells expressing an mFBP were highly sensitive to growth inhibition by DDATHF, and (c) protection against this growth inhibition could be achieved using folic acid rather than reduced folate compounds.	Folic Acid	356-362	far upstream element (FUSE) binding protein 1	Mus musculus	89-93
2060081-4	1991	The role of an mFBP in the uptake of DDATHF was suggested from observations that (a) the mFBP showed a very high binding affinity for DDATHF, (b) murine and human leukemia cells expressing an mFBP were highly sensitive to growth inhibition by DDATHF, and (c) protection against this growth inhibition could be achieved using folic acid rather than reduced folate compounds.	Folic Acid	356-362	far upstream element (FUSE) binding protein 1	Mus musculus	89-93
2351622-8	1990	In the incubation experiment with 10-1000 mg/l of folic acid, 2-MIB and geosmin increased only during the 1000 mg/l addition.	Folic Acid	50-60	MIB E3 ubiquitin protein ligase 1	Homo sapiens	64-67
34864452-0	2022	Folic acid oversupplementation during pregnancy disorders lipid metabolism in male offspring via regulating arginase 1-associated NOS3-AMPKalpha pathway.	Folic Acid	0-10	nitric oxide synthase 3	Rattus norvegicus	130-134
34864452-10	2022	CONCLUSIONS: Our data suggest that maternal folic acid oversupplementation during pregnancy contributes to lipid metabolism disorder in male offspring by regulating Arg1-NOS3-AMPKalpha pathway.	Folic Acid	44-54	nitric oxide synthase 3	Rattus norvegicus	170-174
34836291-2	2021	Similarly to B12 and B6, vitamin B9 is involved in the metabolism of homocysteine, which is associated with the MTHFR gene.	Folic Acid	25-35	methylenetetrahydrofolate reductase	Homo sapiens	112-117
34831280-7	2021	Furthermore, STAT6 knockout mice exhibited significantly less CD206 and PDGFR-beta dual-positive fibroblast accumulation and M2 macrophage polarization in the kidney with folic acid nephropathy.	Folic Acid	171-181	mannose receptor, C type 1	Mus musculus	62-67
34761111-1	2021	MTHFR is a crucial enzyme in folate metabolism.	Folic Acid	29-35	methylenetetrahydrofolate reductase	Homo sapiens	0-5
34727921-11	2021	Finally six hub genes of PGA were identified, including ADCY2, CXCL1, FPRL1, GPR109B, GPR109A and ADCY3, which were validated in a separate dataset of GSE137268.	Folic Acid	25-28	C-X-C motif chemokine ligand 1	Homo sapiens	63-68
34727921-11	2021	Finally six hub genes of PGA were identified, including ADCY2, CXCL1, FPRL1, GPR109B, GPR109A and ADCY3, which were validated in a separate dataset of GSE137268.	Folic Acid	25-28	adenylate cyclase 3	Homo sapiens	98-103
34769063-3	2021	In this study, we found that folate antagonists, such as methotrexate (MTX) and pemetrexed, are selectively cytotoxic to GSCs, but not to their differentiated counterparts, normal fibroblasts, or neural stem cells in vitro, and that the high sensitivity of GCSs to anti-folates may be due to the increased expression of RFC-1/SLC19A1, the reduced folate carrier that transports MTX into cells, in GSCs.	Folic Acid	29-35	replication factor C subunit 1	Homo sapiens	320-325
34769063-3	2021	In this study, we found that folate antagonists, such as methotrexate (MTX) and pemetrexed, are selectively cytotoxic to GSCs, but not to their differentiated counterparts, normal fibroblasts, or neural stem cells in vitro, and that the high sensitivity of GCSs to anti-folates may be due to the increased expression of RFC-1/SLC19A1, the reduced folate carrier that transports MTX into cells, in GSCs.	Folic Acid	270-277	replication factor C subunit 1	Homo sapiens	320-325
34829516-3	2021	We found that CRIF1 downregulation caused significant increases in intracellular and plasma concentrations of homocysteine, which were associated with decreased levels of folate cycle intermediates such as 5-methyltetrahydrofolate (MTHF) and tetrahydrofolate (THF).	Folic Acid	171-177	growth arrest and DNA-damage-inducible, gamma interacting protein 1	Mus musculus	14-19
34829516-4	2021	Moreover, dihydrofolate reductase (DHFR), a key enzyme in folate-mediated metabolism, exhibited impaired activity and decreased protein expression in CRIF1 knockdown endothelial cells.	Folic Acid	58-64	growth arrest and DNA-damage-inducible, gamma interacting protein 1	Mus musculus	150-155
34383924-0	2021	Reduced Shmt2 Expression Impairs Mitochondrial Folate Accumulation and Respiration, and Leads to Uracil Accumulation in Mouse Mitochondrial DNA.	Folic Acid	47-53	serine hydroxymethyltransferase 2 (mitochondrial)	Mus musculus	8-13
34383924-9	2021	Interestingly, Shmt2+/- mice consuming the folate-sufficient C diet exhibited a 25% reduction in total folate in liver mitochondria.	Folic Acid	43-49	serine hydroxymethyltransferase 2 (mitochondrial)	Mus musculus	15-20
34383924-9	2021	Interestingly, Shmt2+/- mice consuming the folate-sufficient C diet exhibited a 25% reduction in total folate in liver mitochondria.	Folic Acid	103-109	serine hydroxymethyltransferase 2 (mitochondrial)	Mus musculus	15-20
34474604-0	2021	Folic acid deficiency damages male reproduction via endoplasmic reticulum stress-associated PERK pathway induced by Caveolin-1 in mice.	Folic Acid	0-10	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	92-96
34474604-7	2021	Meanwhile, folic acid deficiency decreased Cav-1 expression in the testis tissue and increased endoplasmic reticulum stress-related PERK, eIF2alpha, ATF4, CHOP gene expression.	Folic Acid	11-21	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	132-136
34474604-8	2021	Our results suggest that folic acid deficiency can affect male reproduction through the Cav-1-PERK-eIFalpha-ATF4-CHOP pathway.Abbreviations: ATF4: activating transcription factor 4; Ca2+: calcium ion; Cav-1: Caveolin-1; CCK-8: cell counting kit-8; CHOP: CCAAT-enhancer-binding protein homologous protein; DNA: Deoxyribonucleic acid; DSB: double strand breakage; eIF2alpha: eukaryotic Initiation Factor 2 alpha; ER: endoplasmic reticulum; FD: folic acid deficiency; FITC: fluorescein isothiocyanate; HE: hematoxylin and eosin; H3K4me3: histone H3 lysine 4 trimethylation; PERK: protein kinase RNA-like endoplasmic reticulum kinase; PI: propidium iodide; RT-qPCR: quantitative reverse transcription PCR; TUNEL: TdT mediated dUTP Nick End Labeling.	Folic Acid	25-35	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	571-575
34575930-6	2021	Intervention with a methyl-modulator diet (folate, VB12, choline, betaine, and zinc) immediately before or one week after delivery reversed the expression level of Gas5 lncRNA in the pituitary of the offspring.	Folic Acid	43-49	growth arrest specific 5	Rattus norvegicus	164-168
34378936-5	2021	We also developed a folate-caged pomalidomide-based anaplastic lymphoma kinase (ALK) PROTAC, FA-S2-MS4048, which effectively degraded ALK fusion proteins in cancer cells, again in a FOLR1-dependent manner.	Folic Acid	20-26	ALK receptor tyrosine kinase	Homo sapiens	52-78
34378936-5	2021	We also developed a folate-caged pomalidomide-based anaplastic lymphoma kinase (ALK) PROTAC, FA-S2-MS4048, which effectively degraded ALK fusion proteins in cancer cells, again in a FOLR1-dependent manner.	Folic Acid	20-26	ALK receptor tyrosine kinase	Homo sapiens	80-83
34378936-5	2021	We also developed a folate-caged pomalidomide-based anaplastic lymphoma kinase (ALK) PROTAC, FA-S2-MS4048, which effectively degraded ALK fusion proteins in cancer cells, again in a FOLR1-dependent manner.	Folic Acid	20-26	ALK receptor tyrosine kinase	Homo sapiens	134-137
34376980-2	2021	Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in folate conversion and methylation modification associated with the disease.	Folic Acid	68-74	methylenetetrahydrofolate reductase	Homo sapiens	0-35
34376980-2	2021	Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in folate conversion and methylation modification associated with the disease.	Folic Acid	68-74	methylenetetrahydrofolate reductase	Homo sapiens	37-42
34397023-9	2021	Results: Based on the genotype of MTHFR and MTRR, women were identified as five risk levels of folic acid metabolism.	Folic Acid	95-105	methylenetetrahydrofolate reductase	Homo sapiens	34-39
34244426-2	2021	Here, we show that the mitochondrial methylenetetrahydrofolate dehydrogenase (MTHFD2) is transcriptionally suppressed by p53, and its up-regulation by p53 inactivation leads to increased folate metabolism, de novo purine synthesis, and tumor growth in vivo and in vitro.	Folic Acid	187-193	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	Homo sapiens	78-84
34242313-1	2021	Methylenetetrahydrofolate reductase (MTHFR), a folate-dependent enzyme, is reportedly involved in several cancer types.	Folic Acid	47-53	methylenetetrahydrofolate reductase	Homo sapiens	0-35
34242313-1	2021	Methylenetetrahydrofolate reductase (MTHFR), a folate-dependent enzyme, is reportedly involved in several cancer types.	Folic Acid	47-53	methylenetetrahydrofolate reductase	Homo sapiens	37-42
34214447-2	2021	Deficiency in human 5,10-methylenetetrahydrofolate reductase (MTHFR), the most common inherited disorder of folate metabolism, is caused primarily by rare missense variants.	Folic Acid	108-114	methylenetetrahydrofolate reductase	Homo sapiens	20-60
34214447-2	2021	Deficiency in human 5,10-methylenetetrahydrofolate reductase (MTHFR), the most common inherited disorder of folate metabolism, is caused primarily by rare missense variants.	Folic Acid	108-114	methylenetetrahydrofolate reductase	Homo sapiens	62-67
34214447-4	2021	An important example of this phenomenon is the MTHFR variant p.Ala222Val (c.665C>T), which is carried by half of all humans and has a phenotypic impact that depends on dietary folate.	Folic Acid	176-182	methylenetetrahydrofolate reductase	Homo sapiens	47-52
35452214-3	2022	To augment therapeutic efficacy and tumor selectivity, folic acid (FA)-functionalized carbon dots (CDs) embedded with GOx and paclitaxel (PTX) (FA-CD-(PTX-GOx)) was developed that showed the efficient killing of TNBC, MDA-MB-468 cells over noncancerous HEK 293 cells through synergistic effects of cancer starvation-induced oxidative stress and chemotherapy.	Folic Acid	55-65	hydroxyacid oxidase 1	Homo sapiens	118-121
35452214-3	2022	To augment therapeutic efficacy and tumor selectivity, folic acid (FA)-functionalized carbon dots (CDs) embedded with GOx and paclitaxel (PTX) (FA-CD-(PTX-GOx)) was developed that showed the efficient killing of TNBC, MDA-MB-468 cells over noncancerous HEK 293 cells through synergistic effects of cancer starvation-induced oxidative stress and chemotherapy.	Folic Acid	55-65	FA complementation group D2	Homo sapiens	144-149
35452214-3	2022	To augment therapeutic efficacy and tumor selectivity, folic acid (FA)-functionalized carbon dots (CDs) embedded with GOx and paclitaxel (PTX) (FA-CD-(PTX-GOx)) was developed that showed the efficient killing of TNBC, MDA-MB-468 cells over noncancerous HEK 293 cells through synergistic effects of cancer starvation-induced oxidative stress and chemotherapy.	Folic Acid	55-65	hydroxyacid oxidase 1	Homo sapiens	155-158
35550508-0	2022	CDK12 promotes tumorigenesis but induces vulnerability to therapies inhibiting folate one-carbon metabolism in breast cancer.	Folic Acid	79-85	cyclin dependent kinase 12	Homo sapiens	0-5
35565057-11	2022	CMap-CTD database analyses indicated the expression levels of Tlr2, Ccl2, Cxcl10, Fas, Irf8, Socs3, Stat3, Gbp6, Casp1 and Syk could be reversed by folic acid.	Folic Acid	148-158	C-X-C motif chemokine ligand 10	Homo sapiens	74-80
35565057-11	2022	CMap-CTD database analyses indicated the expression levels of Tlr2, Ccl2, Cxcl10, Fas, Irf8, Socs3, Stat3, Gbp6, Casp1 and Syk could be reversed by folic acid.	Folic Acid	148-158	spleen associated tyrosine kinase	Homo sapiens	123-126
11005799-14	2000	The proposed endogenous role of NAT in folate metabolism, and its multi-allelic nature, indicate that its role in development should be assessed further.	Folic Acid	39-45	bromodomain containing 2	Homo sapiens	32-35
11062308-3	2000	A common genetic variant of the methylenetetrahydrofolate reductase (MTHFR) gene CC 677 T) is associated with thermolability of the MTHFR enzyme and elevated plasma homocysteine concentration, especially in those with low folic acid concentration.	Folic Acid	222-232	methylenetetrahydrofolate reductase	Homo sapiens	32-67
11062308-3	2000	A common genetic variant of the methylenetetrahydrofolate reductase (MTHFR) gene CC 677 T) is associated with thermolability of the MTHFR enzyme and elevated plasma homocysteine concentration, especially in those with low folic acid concentration.	Folic Acid	222-232	methylenetetrahydrofolate reductase	Homo sapiens	69-74
11062308-3	2000	A common genetic variant of the methylenetetrahydrofolate reductase (MTHFR) gene CC 677 T) is associated with thermolability of the MTHFR enzyme and elevated plasma homocysteine concentration, especially in those with low folic acid concentration.	Folic Acid	222-232	methylenetetrahydrofolate reductase	Homo sapiens	132-137
11004224-7	2000	BMI, creatinine clearance, ln-tHcy, and MTHFR genotype influenced ln-folate (lower folate levels for MTHFR 677TT/1298AA versus all other genotype groups: P &lt; 0.05).	Folic Acid	69-75	methylenetetrahydrofolate reductase	Homo sapiens	40-45
11004224-7	2000	BMI, creatinine clearance, ln-tHcy, and MTHFR genotype influenced ln-folate (lower folate levels for MTHFR 677TT/1298AA versus all other genotype groups: P &lt; 0.05).	Folic Acid	69-75	methylenetetrahydrofolate reductase	Homo sapiens	101-106
11004224-10	2000	This study shows that the MTHFR 677TT/1298AA and 677CT/1298AC genotypes are significant predictors of tHcy and folate plasma levels.	Folic Acid	111-117	methylenetetrahydrofolate reductase	Homo sapiens	26-31
11048629-1	2000	To evaluate the relationship between genotypes of methylene tetrahydrofolate reductase (MTHFR), and plasma folate and homocysteine (Hcy) levels in meningomyelocele, 21 Korean patients, 47 of their family members, and 43 healthy controls were recruited.	Folic Acid	70-76	methylenetetrahydrofolate reductase	Homo sapiens	88-93
10986435-7	2000	Thus, a dysfunctional MTHFR partly explains the observed elevated Hcy levels in women with NTD pregnancies, and also in part the protective effect of folate on NTD.	Folic Acid	150-156	methylenetetrahydrofolate reductase	Homo sapiens	22-27
10911368-2	2000	However, influx of [(3)H]MTX by this system is 3-4-fold higher at pH 6 than at pH 7.5, the optimum for RFC-1-mediated folate compound transport.	Folic Acid	118-124	replication factor C subunit 1	Rattus norvegicus	103-108
10911368-10	2000	At the same time, RFC-1 expression, which is detectable in FR3T3 cells at the level of its mRNA and RFC-1 mediated folate compound transport, is increased 3-5-fold in these transfectants.	Folic Acid	115-121	replication factor C subunit 1	Rattus norvegicus	18-23
10911368-10	2000	At the same time, RFC-1 expression, which is detectable in FR3T3 cells at the level of its mRNA and RFC-1 mediated folate compound transport, is increased 3-5-fold in these transfectants.	Folic Acid	115-121	replication factor C subunit 1	Rattus norvegicus	100-105
10911368-13	2000	We conclude that the major route for internalization at a physiological pH of folate compounds in FR3T3 cells is by an acid pH-dependent carrier-mediated system independent of RFC-1 expression and is downregulated by oncogene expression.	Folic Acid	78-84	replication factor C subunit 1	Rattus norvegicus	176-181
10952104-9	2000	These data are consistent with prior observations, which suggest that the T/T genotype is associated with impaired MTHFR activity in vivo and that the cellular impact of this impairment is determined, in part, by folate status.	Folic Acid	213-219	methylenetetrahydrofolate reductase	Homo sapiens	115-120
10993718-3	2000	We isolated a cDNA for the reduced folate carrier (RFC-1) from human skin fibroblasts.	Folic Acid	35-41	replication factor C subunit 1	Homo sapiens	51-56
10919734-8	2000	These data are consistent with an interaction between MTHFR genotype and folate availability.	Folic Acid	73-79	methylenetetrahydrofolate reductase	Homo sapiens	54-59
10894832-2	2000	The four most common functional polymorphisms in genes involved in folate/homocysteine metabolism are methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, methionine synthase (MS) A2756G, and cystathionine beta-synthase (CBS) 844ins68.	Folic Acid	67-73	methylenetetrahydrofolate reductase	Homo sapiens	102-137
10894832-2	2000	The four most common functional polymorphisms in genes involved in folate/homocysteine metabolism are methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, methionine synthase (MS) A2756G, and cystathionine beta-synthase (CBS) 844ins68.	Folic Acid	67-73	methylenetetrahydrofolate reductase	Homo sapiens	139-144
10894832-2	2000	The four most common functional polymorphisms in genes involved in folate/homocysteine metabolism are methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, methionine synthase (MS) A2756G, and cystathionine beta-synthase (CBS) 844ins68.	Folic Acid	67-73	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	164-183
10941256-2	2000	In some cancers, folate and other nutrients involved in the MTHFR metabolic pathway appear to interact with MTHFR polymorphisms to further modify cancer risk.	Folic Acid	17-23	methylenetetrahydrofolate reductase	Homo sapiens	60-65
10941256-2	2000	In some cancers, folate and other nutrients involved in the MTHFR metabolic pathway appear to interact with MTHFR polymorphisms to further modify cancer risk.	Folic Acid	17-23	methylenetetrahydrofolate reductase	Homo sapiens	108-113
10869408-0	2000	Trans-stimulation effects of folic acid derivatives on methotrexate transport by rat renal organic anion transporter, OAT-K1.	Folic Acid	29-39	solute carrier organic anion transporter family member 1A3	Rattus norvegicus	118-124
10869408-2	2000	With Madin-Darby canine kidney (MDCK) cells stably transfected with OAT-K1 cDNA, OAT-K1-mediated methotrexate accumulation was inhibited in the presence of various folic acid derivatives.	Folic Acid	164-174	solute carrier organic anion transporter family member 1A3	Rattus norvegicus	68-74
10869408-2	2000	With Madin-Darby canine kidney (MDCK) cells stably transfected with OAT-K1 cDNA, OAT-K1-mediated methotrexate accumulation was inhibited in the presence of various folic acid derivatives.	Folic Acid	164-174	solute carrier organic anion transporter family member 1A3	Rattus norvegicus	81-87
10833329-11	2000	When broken down into the various 677 ct MTHFR and 2756ag MetSyn genotypes, carriage of the 677ct MTHFR allele appears to affect formyl-H(4)PteGlu metabolism in non-NTD mothers.	Folic Acid	140-146	methylenetetrahydrofolate reductase	Homo sapiens	98-103
10767172-6	2000	DMGDH and SDH also utilize a noncovalently bound folate coenzyme that receives the "1-carbon" groups that are removed by DMGDH and SDH, forming "active formaldehyde."	Folic Acid	49-55	dimethylglycine dehydrogenase	Homo sapiens	0-5
10767172-6	2000	DMGDH and SDH also utilize a noncovalently bound folate coenzyme that receives the "1-carbon" groups that are removed by DMGDH and SDH, forming "active formaldehyde."	Folic Acid	49-55	sarcosine dehydrogenase	Homo sapiens	10-13
10767172-6	2000	DMGDH and SDH also utilize a noncovalently bound folate coenzyme that receives the "1-carbon" groups that are removed by DMGDH and SDH, forming "active formaldehyde."	Folic Acid	49-55	dimethylglycine dehydrogenase	Homo sapiens	121-126
10767172-6	2000	DMGDH and SDH also utilize a noncovalently bound folate coenzyme that receives the "1-carbon" groups that are removed by DMGDH and SDH, forming "active formaldehyde."	Folic Acid	49-55	sarcosine dehydrogenase	Homo sapiens	131-134
10723269-6	2000	When expressed in Xenopus oocytes, OAT-K1 mediated the uptake of MTX and folate, but not of taurocholate (TCA) and prostaglandin E2 (PGE2), although OAT-K2 stimulated the uptake of MTX, folate, TCA and PGE2.	Folic Acid	73-79	solute carrier organic anion transporter family member 1A3	Rattus norvegicus	35-41
10723269-6	2000	When expressed in Xenopus oocytes, OAT-K1 mediated the uptake of MTX and folate, but not of taurocholate (TCA) and prostaglandin E2 (PGE2), although OAT-K2 stimulated the uptake of MTX, folate, TCA and PGE2.	Folic Acid	186-192	solute carrier organic anion transporter family member 1A3	Rattus norvegicus	35-41
10723269-6	2000	When expressed in Xenopus oocytes, OAT-K1 mediated the uptake of MTX and folate, but not of taurocholate (TCA) and prostaglandin E2 (PGE2), although OAT-K2 stimulated the uptake of MTX, folate, TCA and PGE2.	Folic Acid	186-192	solute carrier organic anion transporter family member 1A3	Rattus norvegicus	149-155
10375617-1	1999	Decreased reduced folate carrier (RFC) activity has been associated with MTX resistance in experimental models of transport-mediated MTX resistance, and has been attributed to changes in the expression of RFC1, the gene that encodes a protein with this activity.	Folic Acid	18-24	replication factor C subunit 1	Homo sapiens	205-209
10360632-2	1999	A common mutation (C677T) in the gene encoding for the enzyme methylenetetrahydrofolate reductase (MTHFR) has been linked to increased plasma homocysteine levels in homozygous carriers, particularly in the presence of low folate levels.	Folic Acid	81-87	methylenetetrahydrofolate reductase	Homo sapiens	99-104
10212171-1	1999	OBJECTIVE: To determine the effects of the thermolabile methylene tetrahydrofolate reductase (MTHFR) mutation on the presence and extent of coronary atherosclerosis in a population with low plasma folate.	Folic Acid	76-82	methylenetetrahydrofolate reductase	Homo sapiens	94-99
10222379-5	1999	The complex interaction between this common genetic polymorphism of MTHFR and folate intake is the focus of intense investigation.	Folic Acid	78-84	methylenetetrahydrofolate reductase	Homo sapiens	68-73
10332959-9	1999	This work provides a new panel of genetic variants for studies of folate metabolism and supports, in some NTD populations, an association between MTHFR and NTDs.	Folic Acid	66-72	methylenetetrahydrofolate reductase	Homo sapiens	146-151
10220346-2	1999	Previous steady-state kinetic studies indicated that replacement of glutamine at position 214 (Gln214) of hTS by other residues results in a decrease in nucleotide binding and catalysis, with only minor effects on folate binding (D. J. Steadman et al.	Folic Acid	214-220	APC down-regulated 1	Homo sapiens	106-109
10220346-9	1999	In addition, the binding of the folate analogue, CB3717, to dUMP binary complexes of mutant enzymes was characterized by a slow isomerization phase that was not detected in binding studies utilizing wild-type hTS.	Folic Acid	32-38	APC down-regulated 1	Homo sapiens	209-212
10027946-2	1999	The 5,10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphism C677T has been shown to result in increased total homocysteine concentrations on the basis of low folate levels caused by a decreased enzyme activity.	Folic Acid	28-34	methylenetetrahydrofolate reductase	Homo sapiens	46-51
10027946-9	1999	The MTHFR C677T gene polymorphism significantly influenced total homocysteine and folate plasma concentrations in renal transplant recipients (P = 0.0009 and P = 0.0002, respectively).	Folic Acid	82-88	methylenetetrahydrofolate reductase	Homo sapiens	4-9
10027946-14	1999	CONCLUSIONS: This study demonstrates that homozygosity for the C677T polymorphism in the MTHFR gene significantly increases total homocysteine concentrations and lowers folate levels in kidney graft recipients, even in patients with excellent renal function (GFR more than median).	Folic Acid	169-175	methylenetetrahydrofolate reductase	Homo sapiens	89-94
9974399-2	1999	Homozygosity for the C677T mutation in the gene for 5,10-methylenetetrahydrofolate reductase (MTHFR) is frequently associated with hyperhomocysteinemia, particularly in individuals with low levels of serum folate, and has been directly associated with cardiovascular disease in certain populations.	Folic Acid	76-82	methylenetetrahydrofolate reductase	Homo sapiens	94-99
10094554-1	1999	FRAXA, FRAXE, and FRAXF are folate-sensitive fragile sites originally discovered in patients with X-linked mental retardation.	Folic Acid	28-34	transmembrane protein 185A	Homo sapiens	18-23
9668089-0	1998	A mutated murine reduced folate carrier (RFC1) with increased affinity for folic acid, decreased affinity for methotrexate, and an obligatory anion requirement for transport function.	Folic Acid	75-85	solute carrier family 19 (folate transporter), member 1	Mus musculus	41-45
9674907-0	1998	Low blood folates in NTD pregnancies are only partly explained by thermolabile 5,10-methylenetetrahydrofolate reductase: low folate status alone may be the critical factor.	Folic Acid	10-17	methylenetetrahydrofolate reductase	Homo sapiens	79-119
9674907-0	1998	Low blood folates in NTD pregnancies are only partly explained by thermolabile 5,10-methylenetetrahydrofolate reductase: low folate status alone may be the critical factor.	Folic Acid	10-16	methylenetetrahydrofolate reductase	Homo sapiens	79-119
9674907-1	1998	Thermolabile 5,10-methylenetetrahydrofolate reductase (MTHFR) is the first folate-related variant to be associated with an increased risk of neural tube defects (NTDs).	Folic Acid	37-43	methylenetetrahydrofolate reductase	Homo sapiens	55-60
9674907-3	1998	We examined the relationship between folate status and presence of the common mutation MTHFR C677T in 82 NTD-affected and 260 control mothers.	Folic Acid	37-43	methylenetetrahydrofolate reductase	Homo sapiens	87-92
9674907-7	1998	This study shows that homozygosity for the C677T MTHFR variant cannot account for reduced blood folate levels in many NTD-affected mothers.	Folic Acid	96-102	methylenetetrahydrofolate reductase	Homo sapiens	49-54
9596662-8	1998	A genotype/phenotype correlation study showed a marked effect of folate on the association between MTHFR genotypes and tHcy.	Folic Acid	65-71	methylenetetrahydrofolate reductase	Homo sapiens	99-104
9667396-7	1998	Folic acid acts to increase the activity of the variant methylenetetrahydrofolate reductase thereby reducing plasma homocysteine levels.	Folic Acid	0-10	methylenetetrahydrofolate reductase	Homo sapiens	56-91
9607212-7	1998	Folate levels in peritoneal dialysis patients were significantly affected by the MTHFR genotype (P = 0.016).	Folic Acid	0-6	methylenetetrahydrofolate reductase	Homo sapiens	81-86
9550581-0	1998	Whole-blood folate values in subjects with different methylenetetrahydrofolate reductase genotypes: differences between the radioassay and microbiological assays.	Folic Acid	12-18	methylenetetrahydrofolate reductase	Homo sapiens	53-88
9316839-0	1997	Folate depletion induced by methotrexate affects methionine synthase activity and its susceptibility to inactivation by nitrous oxide.	Folic Acid	0-6	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	49-68
9303018-10	1997	CONCLUSIONS: In patients with CVD we confirmed a relationship between the MTHFR genotype and serum homocysteine concentration and an interaction with serum folate concentration.	Folic Acid	156-162	methylenetetrahydrofolate reductase	Homo sapiens	74-79
9212241-0	1997	Reduced folate carrier gene (RFC1) expression and anti-folate resistance in transfected and non-selected cell lines.	Folic Acid	8-14	replication factor C subunit 1	Homo sapiens	29-33
9192787-7	1997	Folate-deficient erythroblasts cultured in folate-deficient medium had marked decreases in all coenzyme forms of folate that persisted throughout culture, increased uracil misincorporation into DNA, persistent accumulations of p53 and p21, and decreased reticulocyte production but increased size of individual reticulocytes.	Folic Acid	0-6	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	235-238
9192787-7	1997	Folate-deficient erythroblasts cultured in folate-deficient medium had marked decreases in all coenzyme forms of folate that persisted throughout culture, increased uracil misincorporation into DNA, persistent accumulations of p53 and p21, and decreased reticulocyte production but increased size of individual reticulocytes.	Folic Acid	43-49	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	235-238
9194768-0	1997	The effects of folic acid supplementation on plasma total homocysteine are modulated by multivitamin use and methylenetetrahydrofolate reductase genotypes.	Folic Acid	15-25	methylenetetrahydrofolate reductase	Homo sapiens	109-144
9194768-2	1997	Folic acid (FA) supplementation usually lowers tHcy levels, but initial tHcy and vitamin levels, multivitamin use, and polymorphisms in the gene for 5, 10-methylenetetrahydrofolate reductase (MTHFR) may contribute to variability in reduction.	Folic Acid	0-10	methylenetetrahydrofolate reductase	Homo sapiens	152-190
9194768-2	1997	Folic acid (FA) supplementation usually lowers tHcy levels, but initial tHcy and vitamin levels, multivitamin use, and polymorphisms in the gene for 5, 10-methylenetetrahydrofolate reductase (MTHFR) may contribute to variability in reduction.	Folic Acid	0-10	methylenetetrahydrofolate reductase	Homo sapiens	192-197
9099956-6	1997	Although it cannot be stated that MTHFR is the target gene of the chromosomal loss involving the 1p36.3 region, a correlation between loss of heterozygosity at this locus and decrease in MTHFR activity was shown, suggesting a role of these allelic deletions in generating a biochemical defect in folate metabolism.	Folic Acid	296-302	methylenetetrahydrofolate reductase	Homo sapiens	187-192
8911125-7	1996	Inhibition of thymidylate synthase, the enzyme involved in IdU dehalogenation, by 5-fluorouracil plus folic acid, or by novel inhibitors AG337 and ZD1694 led to a 3- to 5-fold increase in the 125IdU incorporation.	Folic Acid	102-112	thymidylate synthase	Mus musculus	14-34
8664315-2	1996	In this investigation, we screened a mouse intestinal cDNA library using as probe the cDNA clone of a reduced folate carrier (RFC1) of mouse leukemia L1210 cells, and identified a positive clone, IFC1(RFC1).	Folic Acid	110-116	solute carrier family 19 (folate transporter), member 1	Mus musculus	196-200
9125297-6	1996	Peritoneal macrophages of the folic acid deficient animals exhibited greater (20 x) tissue factor (TF) activity than in the controls.	Folic Acid	30-40	coagulation factor III, tissue factor	Rattus norvegicus	84-97
9125297-6	1996	Peritoneal macrophages of the folic acid deficient animals exhibited greater (20 x) tissue factor (TF) activity than in the controls.	Folic Acid	30-40	coagulation factor III, tissue factor	Rattus norvegicus	99-101
9125297-15	1996	From these results, we conclude that folate deficiency can potentiate the coagulation pathway mediated by the macrophage TF as well as the platelet activation process.	Folic Acid	37-43	coagulation factor III, tissue factor	Rattus norvegicus	121-123
8612303-2	1996	The aim of the design program was to identify TS inhibitors with different pharmacological characteristics from classical folate analogs and, most notably, to develop non-glutamate-containing molecules which would not require facilitated transport for uptake and would not undergo intracellular polyglutamylation.	Folic Acid	122-128	thymidylate synthase	Mus musculus	46-48
8616944-6	1996	CONCLUSIONS: Individuals with thermolabile MTHFR may have a higher folate requirement for regulation of plasma homocysteine concentrations; folate supplementation may be necessary to prevent fasting hyperhomocysteinemia in such persons.	Folic Acid	67-73	methylenetetrahydrofolate reductase	Homo sapiens	43-48
8548458-2	1996	The Class I glutamine amidotransferase domain of GMP synthetase is found in related enzymes of the purine, pyrimidine, tryptophan, arginine, histidine and folic acid biosynthetic pathways.	Folic Acid	155-165	guanine monophosphate synthase	Homo sapiens	49-63
8521402-0	1995	Enhanced antitumor activity for the thymidylate synthase inhibitor 1843U89 through decreased host toxicity with oral folic acid.	Folic Acid	117-127	thymidylate synthase	Mus musculus	36-56
8521402-1	1995	The purpose of this investigation was to determine whether antitumor selectivity of the third generation thymidylate synthase inhibitor 1843U89 could be enhanced by a combination of the drug with folic acid.	Folic Acid	196-206	thymidylate synthase	Mus musculus	105-125
7641195-9	1995	Finally, MTXR ZR-75-1 cells transfected with an RFC1 gene showed increased MTX uptake, which was more sensitive to competition by folinic acid than by folic acid.	Folic Acid	151-161	replication factor C subunit 1	Homo sapiens	48-52
7641196-1	1995	The role of a membrane-associated folate binding protein (mFBP) in transport of folate analogues was investigated in three epithelial cell lines that were grown in high folate medium and folate-conditioned medium and express different levels of mFBP: human nasopharyngeal KB cells, monkey kidney MA104 cells, and IGROV-I ovarian carcinoma cells.	Folic Acid	34-40	far upstream element (FUSE) binding protein 1	Mus musculus	58-62
7641196-1	1995	The role of a membrane-associated folate binding protein (mFBP) in transport of folate analogues was investigated in three epithelial cell lines that were grown in high folate medium and folate-conditioned medium and express different levels of mFBP: human nasopharyngeal KB cells, monkey kidney MA104 cells, and IGROV-I ovarian carcinoma cells.	Folic Acid	80-86	far upstream element (FUSE) binding protein 1	Mus musculus	58-62
7641196-1	1995	The role of a membrane-associated folate binding protein (mFBP) in transport of folate analogues was investigated in three epithelial cell lines that were grown in high folate medium and folate-conditioned medium and express different levels of mFBP: human nasopharyngeal KB cells, monkey kidney MA104 cells, and IGROV-I ovarian carcinoma cells.	Folic Acid	80-86	far upstream element (FUSE) binding protein 1	Mus musculus	58-62
7579732-3	1995	Antifolates for which KB-derived mFBP has high affinity (5, 10-dideazatetrahydrofolic acid [DDATHF] and homo-DDATHF [0.24 and 0.78 respectively relative to folic acid]) and low affinity (methotrexate [0.002]) were chosen for this study.	Folic Acid	80-90	far upstream element (FUSE) binding protein 1	Mus musculus	33-37
7993656-10	1994	Based on our hypothesis that an NTD lesion exists upstream from MTHFR, we expound how pteroylmonoglutamate supplementation may protect against NTD (i) by reducing endotoxic homocysteine and (ii) through inhibiting MTHFR (as do dihydrofolates) and thus diverting one carbon units into DNA thymine.	Folic Acid	86-106	methylenetetrahydrofolate reductase	Homo sapiens	64-69
7993656-10	1994	Based on our hypothesis that an NTD lesion exists upstream from MTHFR, we expound how pteroylmonoglutamate supplementation may protect against NTD (i) by reducing endotoxic homocysteine and (ii) through inhibiting MTHFR (as do dihydrofolates) and thus diverting one carbon units into DNA thymine.	Folic Acid	86-106	methylenetetrahydrofolate reductase	Homo sapiens	214-219
8005024-3	1994	The folate cofactor, N5-methyltetrahydrofolate, donates its methyl group to a vitamin B12-dependent enzyme, methionine synthase, which recycles homocysteine back to methionine.	Folic Acid	4-10	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	108-127
8451757-5	1993	Finally, the expression of c-myc and c-fos is induced after unilateral nephrectomy during compensatory renal growth in the remaining kidney and also during regenerative cell proliferation after in vivo application of the strong nephrotoxins folic acid and mercury chloride.	Folic Acid	241-251	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	37-42
1525836-4	1992	We suggest that gamma-glutamyl hydrolase is a proliferating dependent enzyme which together with folypolyglutamate synthetase ensures in cells an appropriate amount of folates in the form of polyglutamates necessary for optimizing folate-dependent biosynthetic activities.	Folic Acid	168-175	gamma-glutamyl hydrolase	Mus musculus	16-40
1525836-4	1992	We suggest that gamma-glutamyl hydrolase is a proliferating dependent enzyme which together with folypolyglutamate synthetase ensures in cells an appropriate amount of folates in the form of polyglutamates necessary for optimizing folate-dependent biosynthetic activities.	Folic Acid	168-174	gamma-glutamyl hydrolase	Mus musculus	16-40
1655252-1	1991	L1210-B73 cells, variants of L1210 cells grown in medium containing nanomolar concentrations of folates, express a membrane associated folate binding protein (mFBP) in addition to the classical reduced folate/methotrexate carrier (RF/MTX-carrier) present in L1210 cells grown in standard high folate medium (G. Jansen et al., Cancer Res., 49: 1959-1963, 1989).	Folic Acid	96-103	far upstream element (FUSE) binding protein 1	Mus musculus	159-163
1655252-1	1991	L1210-B73 cells, variants of L1210 cells grown in medium containing nanomolar concentrations of folates, express a membrane associated folate binding protein (mFBP) in addition to the classical reduced folate/methotrexate carrier (RF/MTX-carrier) present in L1210 cells grown in standard high folate medium (G. Jansen et al., Cancer Res., 49: 1959-1963, 1989).	Folic Acid	96-102	far upstream element (FUSE) binding protein 1	Mus musculus	159-163
1932118-4	1991	The gene is located at 12q13.1, a region of occasional translocations in hematopoietic neoplasia and a rare folic acid fragile site, Fra 12A.	Folic Acid	108-118	fragile site, folic acid type, rare, fra(12)(q13.1)	Homo sapiens	133-140
1894617-2	1991	L1210 murine leukemic cells grown under conditions of continuous low folate concentrations acquire increased levels of a high affinity/low capacity folate-binding protein (FBP).	Folic Acid	69-75	far upstream element (FUSE) binding protein 1	Mus musculus	148-170
1894617-2	1991	L1210 murine leukemic cells grown under conditions of continuous low folate concentrations acquire increased levels of a high affinity/low capacity folate-binding protein (FBP).	Folic Acid	69-75	far upstream element (FUSE) binding protein 1	Mus musculus	172-175
2058704-4	1991	Induction of TIS 1, TIS 8, and TIS 11 mRNA levels following folic acid administration peaked at 2 to 4 h and persisted up to 6 to 12 h after mitogenic stimulation.	Folic Acid	60-70	zinc finger protein 36	Mus musculus	31-37
2407589-6	1990	Because inhibition of mammalian methionine synthase can restrict the incorporation of methyltetrahydrofolate from the blood into cellular folate pools that can be used for nucleotide biosynthesis, it is a potential chemotherapeutic target.	Folic Acid	102-108	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	32-51
34808323-0	2022	Excess Folic Acid Supplementation Before and During Pregnancy and Lactation Activates beta-catenin in the Brain of Male Mouse Offspring.	Folic Acid	7-17	catenin (cadherin associated protein), beta 1	Mus musculus	86-98
34967850-8	2022	RESULTS: After correction for multiple comparisons, among NHW women, 5,10-methylenetetrahydrofolate reductase (MTHFR) rs1801133 (677C T) variant T was associated with lower plasma folate (-13.0%, 95% CI = -17.3% to -8.6%) and higher plasma homocysteine (3.5%, 95% CI = 1.7% to 5.3%) concentrations.	Folic Acid	180-186	methylenetetrahydrofolate reductase	Homo sapiens	69-109
34967850-8	2022	RESULTS: After correction for multiple comparisons, among NHW women, 5,10-methylenetetrahydrofolate reductase (MTHFR) rs1801133 (677C T) variant T was associated with lower plasma folate (-13.0%, 95% CI = -17.3% to -8.6%) and higher plasma homocysteine (3.5%, 95% CI = 1.7% to 5.3%) concentrations.	Folic Acid	180-186	methylenetetrahydrofolate reductase	Homo sapiens	111-116
34967850-11	2022	Highest vs. lowest quartiles of aggregated genetic risk scores from SNVs in MTHFR and MTRR were associated with 14.8% to 18.9% lower RBC folate concentrations.	Folic Acid	137-143	methylenetetrahydrofolate reductase	Homo sapiens	76-81
34953021-4	2022	Then through reduced representation bisulphite sequencing, global DNA methylation of sperm of patients in the low folic acid group and the high folic acid group was analysed, it was found that the methylation level in Rad54 promoter region increased in the folic acid deficiency group compared with the normal folic acid group.	Folic Acid	114-124	RAD54 like	Homo sapiens	218-223
34953021-4	2022	Then through reduced representation bisulphite sequencing, global DNA methylation of sperm of patients in the low folic acid group and the high folic acid group was analysed, it was found that the methylation level in Rad54 promoter region increased in the folic acid deficiency group compared with the normal folic acid group.	Folic Acid	144-154	RAD54 like	Homo sapiens	218-223
34953021-4	2022	Then through reduced representation bisulphite sequencing, global DNA methylation of sperm of patients in the low folic acid group and the high folic acid group was analysed, it was found that the methylation level in Rad54 promoter region increased in the folic acid deficiency group compared with the normal folic acid group.	Folic Acid	257-267	RAD54 like	Homo sapiens	218-223
34953021-4	2022	Then through reduced representation bisulphite sequencing, global DNA methylation of sperm of patients in the low folic acid group and the high folic acid group was analysed, it was found that the methylation level in Rad54 promoter region increased in the folic acid deficiency group compared with the normal folic acid group.	Folic Acid	310-320	RAD54 like	Homo sapiens	218-223
34960114-1	2021	The 5-10-methylenetetrahydrofolate reductase (MTHFR) enzyme is vital for cellular homeostasis due to its key functions in the one-carbon cycle, which include methionine and folate metabolism and protein, DNA, and RNA synthesis.	Folic Acid	173-179	methylenetetrahydrofolate reductase	Homo sapiens	4-44
34960114-1	2021	The 5-10-methylenetetrahydrofolate reductase (MTHFR) enzyme is vital for cellular homeostasis due to its key functions in the one-carbon cycle, which include methionine and folate metabolism and protein, DNA, and RNA synthesis.	Folic Acid	173-179	methylenetetrahydrofolate reductase	Homo sapiens	46-51
34959947-6	2021	Furthermore, biological pathways leading to rumination appeared to differ according to folate intake: purinergic signaling and circadian regulator gene ARNTL emerged in the whole sample, blastocyst development, DNA replication, and C-C chemokines in the suboptimal folate group, and prostaglandin response and K+ channel subunit gene KCNH3 in the optimal folate group.	Folic Acid	87-93	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	152-157
34889054-5	2021	We found an upregulation of genes involved in the oxidative branch of the pentose phosphate pathways (PPP) and mitochondrial branch of the folate cycle suggesting an increase in the production of NADPH.	Folic Acid	139-145	2,4-dienoyl-CoA reductase 1	Homo sapiens	196-201
34560414-2	2021	In this study, we designed a folate-grafted PEI600-CyD (H1) nanoparticle-mediated DNA vaccine containing an adjuvant of high mobility group box 1 protein (HMGB1) and a tumor-specific antigen of B7H3 (CD276) for renal carcinoma therapy.	Folic Acid	29-35	CD276 antigen	Mus musculus	194-198
34560414-2	2021	In this study, we designed a folate-grafted PEI600-CyD (H1) nanoparticle-mediated DNA vaccine containing an adjuvant of high mobility group box 1 protein (HMGB1) and a tumor-specific antigen of B7H3 (CD276) for renal carcinoma therapy.	Folic Acid	29-35	CD276 antigen	Mus musculus	200-205
34799699-2	2021	The most abundant circulating folate species is 5-methyl tetrahydrofolate (5-methyl-THF), which is used to synthesize methionine from homocysteine via the cobalamin-dependent enzyme methionine synthase (MTR).	Folic Acid	30-36	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	182-201
34799701-0	2021	Methionine synthase is essential for cancer cell proliferation in physiological folate environments.	Folic Acid	80-86	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	0-19
34799701-3	2021	We find that the enzyme that couples folate and methionine metabolic cycles, methionine synthase, is required for cancer cell proliferation and tumour growth when 5-methyl tetrahydrofolate (THF), the major folate found in circulation, is the extracellular folate source.	Folic Acid	37-43	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	77-96
34799701-3	2021	We find that the enzyme that couples folate and methionine metabolic cycles, methionine synthase, is required for cancer cell proliferation and tumour growth when 5-methyl tetrahydrofolate (THF), the major folate found in circulation, is the extracellular folate source.	Folic Acid	206-212	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	77-96
34799701-3	2021	We find that the enzyme that couples folate and methionine metabolic cycles, methionine synthase, is required for cancer cell proliferation and tumour growth when 5-methyl tetrahydrofolate (THF), the major folate found in circulation, is the extracellular folate source.	Folic Acid	256-262	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	77-96
34799701-4	2021	In such physiological conditions, methionine synthase incorporates 5-methyl THF into the folate cycle to maintain intracellular levels of the folates needed for nucleotide production.	Folic Acid	89-95	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	34-53
34799701-4	2021	In such physiological conditions, methionine synthase incorporates 5-methyl THF into the folate cycle to maintain intracellular levels of the folates needed for nucleotide production.	Folic Acid	142-149	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	34-53
34586802-6	2021	Furthermore, siERN1-nanoprodrug (FA (folic acid)-PEG-R(RKKRRQRRR)-NPs(ss-PBAA-PEI)@siERN1) acts as a conductor of macrophage polarization by controlling the calcium ion concentration and is an inhibitor of MyD88-dependent Toll-like receptor signaling.	Folic Acid	37-47	myeloid differentiation primary response gene 88	Mus musculus	206-211
34899024-0	2021	Effects of Thermal Conditioning and Folic Acid on Methylation of the BDNF Promoter Region in Chicks.	Folic Acid	36-46	brain derived neurotrophic factor	Homo sapiens	69-73
34899024-1	2021	This study aimed to investigate the effects of thermal conditioning and folic acid on the methylation levels of the avian brain-derived neurotrophic factor (BDNF) promoter region at the M3 and M9 positions in the early life of broiler chicks.	Folic Acid	72-82	brain derived neurotrophic factor	Homo sapiens	122-155
34899024-1	2021	This study aimed to investigate the effects of thermal conditioning and folic acid on the methylation levels of the avian brain-derived neurotrophic factor (BDNF) promoter region at the M3 and M9 positions in the early life of broiler chicks.	Folic Acid	72-82	brain derived neurotrophic factor	Homo sapiens	157-161
34678082-8	2021	In conclusion, this study found that folic acid inhibited the formation of VM in Eca-109 cells, and the one target protein was EphA2.	Folic Acid	37-47	EPH receptor A2	Homo sapiens	127-132
34104947-0	2021	A high level of KLF12 causes folic acid-resistant neural tube defects by activating the Shh signalling pathway in mice.	Folic Acid	29-39	Kruppel-like factor 12	Mus musculus	16-21
34171147-5	2021	PSS30 encodes a folate transporter, AtFOLT1, which was previously localized to chloroplasts and implicated in the transport of folate from the cytosol to plastids.	Folic Acid	127-133	folate transporter 1	Arabidopsis thaliana	36-43
34171147-7	2021	As compared to the wild-type Col-0 ecotype, the steady state folate levels are reduced in the pss1, atfolt1 and two folate biosynthetic mutants suggesting that folate is required for expression of nonhost immunity.	Folic Acid	61-67	folate transporter 1	Arabidopsis thaliana	100-107
34502300-3	2021	Methylenetetrahydrofolate reductase (MTHFR) is the enzyme catalyzing the irreversible conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate that can control folate cofactor distributions and modulate the partitioning of intracellular one-carbon moieties.	Folic Acid	176-182	methylenetetrahydrofolate reductase	Homo sapiens	0-35
34502300-3	2021	Methylenetetrahydrofolate reductase (MTHFR) is the enzyme catalyzing the irreversible conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate that can control folate cofactor distributions and modulate the partitioning of intracellular one-carbon moieties.	Folic Acid	176-182	methylenetetrahydrofolate reductase	Homo sapiens	37-42
34307341-7	2021	The most significantly biological processes and pathways overrepresented in the NSCPO-identified genes were associated with the folic acid metabolism, highlighting the interaction between LDL receptor-related protein 6 (LRP6) and 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR) that interconnect two large networks.	Folic Acid	128-138	LDL receptor related protein 6	Homo sapiens	188-218
34307341-7	2021	The most significantly biological processes and pathways overrepresented in the NSCPO-identified genes were associated with the folic acid metabolism, highlighting the interaction between LDL receptor-related protein 6 (LRP6) and 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR) that interconnect two large networks.	Folic Acid	128-138	LDL receptor related protein 6	Homo sapiens	220-224
34291044-5	2021	During growth, cln5 - cells displayed reduced cell proliferation, cytokinesis, viability, and folic acid-mediated chemotaxis.	Folic Acid	94-104	CLN5 intracellular trafficking protein	Homo sapiens	15-19
34250253-7	2021	A significant correlation was noticed between PGA-IgA and CD4+ CXCR5+ Tfh cells (r = 0.380 and P = 0.042) and CD4+ CXCR5+ ICOS+ Tfh cells (r = 0.906 and P < 0.001).	Folic Acid	46-49	C-X-C motif chemokine receptor 5	Homo sapiens	63-68
34611067-11	2021	Among the high-risk cardiovascular group (CRP>3, n=49), there is a moderate negative correlation between serum folic acid and homocysteine level (p<=0.001; r=-0.561) and a weak negative correlation between vitamin B12 and homocysteine level (p=0.018; r=-0.338).	Folic Acid	111-121	CCAAT enhancer binding protein delta	Homo sapiens	42-47
34108628-3	2021	In this research, a novel zinc-based nanoscale metal-organic framework (Zn-NMOF) coated with folic acid (FA) functionalized chitosan (CS) has been constructed and applied as efficient delivery of LNA (locked nucleic acid)-antisense miR-224 to colon cancer cell lines.	Folic Acid	93-103	microRNA 224	Homo sapiens	232-239
35316219-6	2022	Lastly, we found that topical treatment with AhR antagonists vitamin B12 and folic acid ameliorated UVB-induced wrinkle formation in mice while dampening MMP2 expression in the skin.	Folic Acid	77-87	matrix metallopeptidase 2	Mus musculus	154-158
35139535-9	2022	Finally, folic acid (FA) significantly attenuated aortic valve calcification in WD-fed Apoe-/- mice through increasing DHFR and salvaging BH4 biosynthesis.	Folic Acid	9-19	dihydrofolate reductase	Mus musculus	119-123
35316734-9	2022	When the concentration of folic acid was tested, 20 muM and 500 muM presented a higher level of insulin-like growth factor (IGF2) DNA methylation pattern compared to control, suggesting that in vitro conditions alter DNA methylation pattern in that region and folic acid reestablishes the pattern.	Folic Acid	26-36	insulin like growth factor 2	Bos taurus	124-128
35316734-9	2022	When the concentration of folic acid was tested, 20 muM and 500 muM presented a higher level of insulin-like growth factor (IGF2) DNA methylation pattern compared to control, suggesting that in vitro conditions alter DNA methylation pattern in that region and folic acid reestablishes the pattern.	Folic Acid	260-270	insulin like growth factor 2	Bos taurus	124-128
35578613-12	2022	Folic acid supplementation was also observed to significantly decrease global methylation in placental trophoblasts related to decreasing expression of DNMT1 and DNMT3A.	Folic Acid	0-10	DNA methyltransferase 1	Homo sapiens	152-157
35370749-7	2022	In LPS-induced ALI mice, FOL administration showed inhibition of IL-1beta, IL-6, and TNF-alpha in Bronchoalveolar lavage fluid (BALF) and decreased protein expression levels of PI3K, AKT, NF-kappaB p50, and NF-kappaB p65, and elevated protein expression levels of Bax and cleaved-caspase-3 significantly.	Folic Acid	25-28	BCL2-associated X protein	Mus musculus	264-267
35126709-8	2022	Western blotting demonstrated that the expression levels of ERbeta and the phosphorylation levels of PI3K and AKT were decreased, whilst the expression levels of cleaved caspase-3 were increased, in the cerebral cortex of female mice that received folate-deficient diet.	Folic Acid	248-254	caspase 3	Mus musculus	170-179
35268281-7	2022	However, the relationships between erythrocyte folate concentrations and the occurrence of alternative variants: c.665C>T MTHFR and c.776G>C TCN2, as well as the methylmalonic acid concentration and the occurrence of alternative variant c.776G>C TCN2 in pregnant women with fetal-T21, encourage further research.	Folic Acid	47-53	methylenetetrahydrofolate reductase	Homo sapiens	122-127
35135596-1	2022	BACKGROUND: MTHFD2 is a folate-coupled metabolic enzyme, which has been proved to participant in the metabolic reprogramming and tumor cell-sustaining proliferative capacity.	Folic Acid	24-30	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	Homo sapiens	12-18
2514611-9	1989	Whereas intracellular dihydrofolate reductase catalytic activity was relatively unchanged throughout the cell cycle, as reflected in the metabolism of [3H]folic acid to reduced folate forms, a marked increase in in situ thymidylate synthase activity occurred during S phase that was tightly linked to the rate of DNA synthesis.	Folic Acid	29-35	thymidylate synthase	Mus musculus	220-240
2529254-12	1989	These data exclude the possibility that direct inhibition of thymidylate synthase by dihydrofolate polyglutamates, or any other intracellular folates that accumulate in cells after antifolates, can account for the rapid but partial interconversion of reduced folate cofactors to dihydrofolate.	Folic Acid	92-98	thymidylate synthase	Mus musculus	61-81
2451560-3	1988	The depletion of cellular folates produced comparable increases in both cellular methotrexate glutamylation and extract FPGS activity (approximately 1.8-fold).	Folic Acid	26-33	folylpolyglutamate synthase	Rattus norvegicus	120-124
2831173-1	1987	The effect of acute phenobarbitone treatment on the distribution of endogenous bound folates in three specific cytosolic folate-binding proteins (FBP-C), has been studied in rat liver.	Folic Acid	85-92	far upstream element binding protein 1	Rattus norvegicus	146-149
2831173-3	1987	As it is well known that FBP"s preferentially bind longer-chain polyglutamates, the content of which is markedly lower in phenobarbitone-treated rat liver, it might be suggested that shorter chain folates also bind to FBP"s in these animals.	Folic Acid	197-204	far upstream element binding protein 1	Rattus norvegicus	25-28
2831173-3	1987	As it is well known that FBP"s preferentially bind longer-chain polyglutamates, the content of which is markedly lower in phenobarbitone-treated rat liver, it might be suggested that shorter chain folates also bind to FBP"s in these animals.	Folic Acid	197-204	far upstream element binding protein 1	Rattus norvegicus	218-221
3583595-1	1987	The effect of castration and testosterone treatment on the distribution of [3H] radioactive and endogenous bound folates in hepatic cytosolic folate binding proteins (FBP-C) has been studied in rats.	Folic Acid	113-120	far upstream element binding protein 1	Rattus norvegicus	167-170
3583595-2	1987	The distribution of [3H] radioactive bound folates in these FBP"s shows no significant difference in the three experimental group animals.	Folic Acid	43-50	far upstream element binding protein 1	Rattus norvegicus	60-63
3583595-5	1987	The decrease of bound folates in castrated rats might be ascribable to a lower availability of longer-chain forms, almost the ones that bind to FBP"s; however lower binding protein content and/or lower affinity for ligands cannot be excluded.	Folic Acid	22-29	far upstream element binding protein 1	Rattus norvegicus	144-147
2944577-10	1986	We suggest that only doses of the fluoropyrimidines that are capable of initially inhibiting thymidylate synthase to a high degree will be synergistic with excess reduced folates.	Folic Acid	171-178	thymidylate synthase	Mus musculus	93-113
2938731-8	1986	We propose that the elevated TS levels result in sequestration of the reduced-folate pool (as N5,10-methylene tetrahydrofolic acid) into the TS ternary complex with 5-fluoro-2"-deoxyuridine 5"-monophosphate.	Folic Acid	78-84	thymidylate synthase	Mus musculus	29-31
2938731-8	1986	We propose that the elevated TS levels result in sequestration of the reduced-folate pool (as N5,10-methylene tetrahydrofolic acid) into the TS ternary complex with 5-fluoro-2"-deoxyuridine 5"-monophosphate.	Folic Acid	78-84	thymidylate synthase	Mus musculus	141-143
6201178-8	1984	It was further shown that the relative substrate activity of folate analogs for folylpolyglutamate synthetase is dependent on the source of the enzyme.	Folic Acid	61-67	folylpolyglutamate synthase	Rattus norvegicus	80-109
6887234-5	1983	If a two-carrier model is correct, then our data indicate that one of the carriers has low capacity and high affinity for folate coenzymes and methotrexate.	Folic Acid	122-128	interferon alpha	Mus musculus	0-4
7108907-1	1982	Reported antifolate activity against leukemia L1210 by N-[14-[[(2-amino-4-hydroxy-6-quinazolinyl)methyl]-propargylamino]benzoyl]]-L-glu tamic acid through potent inhibition of thymidylate synthase (EC 2.1.1.45) prompted us to include the propargyl group in a study of the effect on folate metabolism and membrane transport of replacing the 10-methyl group of methotrexate with other groups.	Folic Acid	13-19	thymidylate synthase	Mus musculus	176-196
6934068-1	1980	An auxotrophic mutant, GAT-, derived from the Chinese hamster cell line CHO-K1 and exhibiting multiple growth requirements for glycine, adenine, and thymidine, has been shown to be deficient in one of the folate-dependent enzymes, folylpolyglutamate synthetase (FPGS).	Folic Acid	205-211	glycine-N-acyltransferase	Homo sapiens	23-26
311801-1	1979	A rapid radiometric assay for the folate antagonist MTX, based on the inhibition of chicken liver dihydrofolate reductase activity, has been developed.	Folic Acid	34-40	dihydrofolate reductase	Gallus gallus	98-121
186170-2	1976	With use of PNAA the following abnormalities were observed; serum carotene and folate decreased, D-xylose absorption was impaired, fat globules and muscle fibers were demonstrable in the stool, and the mean weight loss in 6 weeks was 10.2% as compared with 4.3% in patients not treated with antibiotics.	Folic Acid	79-85	N-terminal asparagine amidase	Homo sapiens	12-16
823166-5	1976	Chromatographic separation of conjugase treated and untreated samples of cow"s milk has made it possible to distinguish between free and bound forms of folates.	Folic Acid	152-159	gamma-glutamyl hydrolase	Bos taurus	30-39
6054-3	1976	Pediococcus cerevisiae/AMr, resistant to amethopterin, possesses a higher dihydrofolate reductase (5, 6, 7, 8-tetrahydrofolate: NADP+ oxidoreductase, EC 1.5.1.3) activity than the parent, a folate-permeable and thus amethopterin-susceptible strain and than the wild-type.	Folic Acid	81-87	thioredoxin reductase 1	Homo sapiens	134-148
1186901-0	1975	Folate-dependent 1-carbon transfer to biogenic amines mediated by methylenetetrahydrofolate reductase.	Folic Acid	0-6	methylenetetrahydrofolate reductase	Homo sapiens	66-101
33998598-7	2021	Mice with tubule-specific Dach1 deletion developed more severe renal fibrosis both in folic acid and diabetic kidney injury models.	Folic Acid	86-96	dachshund family transcription factor 1	Mus musculus	26-31
33998598-8	2021	Mice with tubule-specific Dach1 overexpression were protected from folic acid nephropathy.	Folic Acid	67-77	dachshund family transcription factor 1	Mus musculus	26-31
33979572-4	2021	Studies investigating the mechanism revealed that PGA diminished the binding efficiency of ETS family of transcription factor (ELK1) and Serum response factor (SRF), and suppressed ELK1-SRF complex-dependent transcription, which decreased the transcriptional levels of downstream genes Early growth response protein 1 (EGR1)-Polycomb ring finger (BMI1), thus inducing the imbalanced regulation between Myeloid cell leukaemia-1 (MCL1) and F-Box and WD repeat domain containing 7 (FBXW7).	Folic Acid	50-53	ETS transcription factor ELK1	Homo sapiens	127-131
33979572-4	2021	Studies investigating the mechanism revealed that PGA diminished the binding efficiency of ETS family of transcription factor (ELK1) and Serum response factor (SRF), and suppressed ELK1-SRF complex-dependent transcription, which decreased the transcriptional levels of downstream genes Early growth response protein 1 (EGR1)-Polycomb ring finger (BMI1), thus inducing the imbalanced regulation between Myeloid cell leukaemia-1 (MCL1) and F-Box and WD repeat domain containing 7 (FBXW7).	Folic Acid	50-53	serum response factor	Homo sapiens	137-158
33979572-4	2021	Studies investigating the mechanism revealed that PGA diminished the binding efficiency of ETS family of transcription factor (ELK1) and Serum response factor (SRF), and suppressed ELK1-SRF complex-dependent transcription, which decreased the transcriptional levels of downstream genes Early growth response protein 1 (EGR1)-Polycomb ring finger (BMI1), thus inducing the imbalanced regulation between Myeloid cell leukaemia-1 (MCL1) and F-Box and WD repeat domain containing 7 (FBXW7).	Folic Acid	50-53	serum response factor	Homo sapiens	160-163
33979572-4	2021	Studies investigating the mechanism revealed that PGA diminished the binding efficiency of ETS family of transcription factor (ELK1) and Serum response factor (SRF), and suppressed ELK1-SRF complex-dependent transcription, which decreased the transcriptional levels of downstream genes Early growth response protein 1 (EGR1)-Polycomb ring finger (BMI1), thus inducing the imbalanced regulation between Myeloid cell leukaemia-1 (MCL1) and F-Box and WD repeat domain containing 7 (FBXW7).	Folic Acid	50-53	ETS transcription factor ELK1	Homo sapiens	181-185
33979572-4	2021	Studies investigating the mechanism revealed that PGA diminished the binding efficiency of ETS family of transcription factor (ELK1) and Serum response factor (SRF), and suppressed ELK1-SRF complex-dependent transcription, which decreased the transcriptional levels of downstream genes Early growth response protein 1 (EGR1)-Polycomb ring finger (BMI1), thus inducing the imbalanced regulation between Myeloid cell leukaemia-1 (MCL1) and F-Box and WD repeat domain containing 7 (FBXW7).	Folic Acid	50-53	serum response factor	Homo sapiens	186-189
22303319-13	2011	Low post-weaning folate increased Apc methylation in Apc(+/Min) mice only (p = 0.008 for interaction).	Folic Acid	17-23	APC, WNT signaling pathway regulator	Mus musculus	34-37
22303319-13	2011	Low post-weaning folate increased Apc methylation in Apc(+/Min) mice only (p = 0.008 for interaction).	Folic Acid	17-23	APC, WNT signaling pathway regulator	Mus musculus	53-56
22303319-15	2011	Also, the differential effects of altered folate supply on DNA methylation in WT and Apc(+/Min) mice suggest that genotype may modulate epigenetic responses to environmental cues and may have implications for the development of personalized nutrition.	Folic Acid	42-48	APC, WNT signaling pathway regulator	Mus musculus	85-88
21430116-3	2011	OBJECTIVE: The objective was to determine whether folic acid supplementation reduces the progression of atherosclerosis as measured by common carotid intima-media thickness (CIMT)-a validated marker of atherosclerosis and predictor of vascular disease risk.	Folic Acid	50-60	CIMT	Homo sapiens	174-178
21430116-8	2011	The mean (+-SE) rate of change in CIMT was 1.9 +- 0.9 mum/y in the folic acid arm and 1.3 +- 0.8 mum/y in the placebo arm (mean difference: 0.7 mum/y; 95% CI: -1.8, 3.1 mum/y; P = 0.59).	Folic Acid	67-77	CIMT	Homo sapiens	34-38
21380490-2	2011	Given that LV effects are attributable to increased levels of reduced folate in cancer cells, we attempted here to show the in vivo role of folylpolyglutamate synthetase (FPGS), which stabilizes intracellular reduced folate, in the anticancer activities of oral fluoropyrimidines, UFT or S-1, combined with LV.	Folic Acid	70-76	folylpolyglutamate synthase	Homo sapiens	171-175
21380490-2	2011	Given that LV effects are attributable to increased levels of reduced folate in cancer cells, we attempted here to show the in vivo role of folylpolyglutamate synthetase (FPGS), which stabilizes intracellular reduced folate, in the anticancer activities of oral fluoropyrimidines, UFT or S-1, combined with LV.	Folic Acid	217-223	folylpolyglutamate synthase	Homo sapiens	140-169
21380490-2	2011	Given that LV effects are attributable to increased levels of reduced folate in cancer cells, we attempted here to show the in vivo role of folylpolyglutamate synthetase (FPGS), which stabilizes intracellular reduced folate, in the anticancer activities of oral fluoropyrimidines, UFT or S-1, combined with LV.	Folic Acid	217-223	folylpolyglutamate synthase	Homo sapiens	171-175
21380490-5	2011	FPGS shRNA HCT-15 tumors expressed a significantly lower level of FPGS at protein and mRNA levels than parental HCT-15 cells, and the levels of reduced folate in FPGS shRNA HCT-15 tumors became 57% of those in parent after a single administration of 10 mg/kg of LV.	Folic Acid	152-158	folylpolyglutamate synthase	Homo sapiens	0-4
21542550-5	2004	Second, FR-alpha isoform is overexpressed on ~40% of human cancers, where it is completely accessible to folate conjugates.	Folic Acid	105-111	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	8-16
21542551-5	2004	Second, FR-alpha isoform is overexpressed on ~40% of human cancers, where it is completely accessible to folate conjugates.	Folic Acid	105-111	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	8-16
21542552-6	2004	The FR-alpha isoform is expressed on the apical (luminal) surface of epithelial cells in limited tissues, and because of no vascular supply, it is inaccessible to exogenous folate conjugates with the exception of the FR-alpha isoforms on the proximal tubules of kidneys (1-3).	Folic Acid	173-179	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	4-12
21542552-10	2004	Second, the FR-alpha isoform is overexpressed in ~40% of human cancer tissues, where it is completely accessible to folate conjugates.	Folic Acid	116-122	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	12-20
21542552-19	2004	MRI with Gd.DOTA.Folate in tumor-bearing mice showed an increase in R1 with clear enhancement on the MRI images in a human ovarian carcinoma (IGROV-1) xenograft overexpressing the FR-alpha isoform, but no change was observed in a FR-alpha-negative human ovarian carcinoma (OVCAR-3) xenograft.	Folic Acid	17-23	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	180-188
21542552-19	2004	MRI with Gd.DOTA.Folate in tumor-bearing mice showed an increase in R1 with clear enhancement on the MRI images in a human ovarian carcinoma (IGROV-1) xenograft overexpressing the FR-alpha isoform, but no change was observed in a FR-alpha-negative human ovarian carcinoma (OVCAR-3) xenograft.	Folic Acid	17-23	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	230-238
21542557-5	2004	Second, the FR-alpha isoform is overexpressed in ~40% of human cancer tissues, where it is completely accessible to folate conjugates, but the FR-alpha is inaccessible for the conjugates in most normal tissues because its expression occurs largely at the apical (luminal) surface of epithelial cells where it is not supplied with blood vessels .	Folic Acid	116-122	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	12-20
21324323-1	2011	AIMS: Folate coenzymes and dependent enzymes introduce one carbon units at positions 2 (C(2)) and 8 (C(8)) of the purine ring during de novo biosynthesis.	Folic Acid	6-12	complement C2	Homo sapiens	88-92
21256110-1	2011	The proton-coupled transporter (PCFT) mediates intestinal folate absorption and folate transport from blood across the choroid plexus.	Folic Acid	58-64	solute carrier family 46 member 1	Homo sapiens	32-36
21256110-1	2011	The proton-coupled transporter (PCFT) mediates intestinal folate absorption and folate transport from blood across the choroid plexus.	Folic Acid	80-86	solute carrier family 46 member 1	Homo sapiens	32-36
21682137-2	2011	PPAR-alpha is involved in wound healing, stimulation of lipid and folic acid catabolism, inflammation control, inhibition of ureagenesis and peroxisome proliferation.	Folic Acid	66-76	peroxisome proliferator activated receptor alpha	Homo sapiens	0-10
20708308-10	2011	CONCLUSION: High consumption of total fat and dietary cholesterol accompanied by a low folate, antioxidant vitamin, a special vitamin C and dietary fiber intake, contributes to elevated Hcy, GGT and MCP-1 levels and in consequence, could lead to intense inflammatory process and atherosclerosis in HF patients.	Folic Acid	87-93	C-C motif chemokine ligand 2	Homo sapiens	199-204
21157027-3	2011	In the current study, we assessed the molecular mechanisms, mainly the modifications in the activity of mitochondrial complexes, whereby the association of folic acid and alpha-tocopherol protects mice against the Abeta-induced neurotoxicity.	Folic Acid	156-166	amyloid beta (A4) precursor protein	Mus musculus	214-219
21765920-10	2011	Prior to correction for multiple testing, we detected significant associations between TCblR rs9426 and methylmalonic acid (p  =  0.045), total homocysteine levels (tHcy) (p  =  0.033), serum B12 (p &lt; 0.0001), holo transcobalamin (p &lt; 0.0001) and total transcobalamin (p &lt; 0.0001); and between MTHFR rs1537514 and red blood cell folate (p &lt; 0.0001).	Folic Acid	338-344	CD320 molecule	Homo sapiens	87-92
21044435-13	2010	Folic acid supplementation may have reduced the efficacy of MTX by interfering with its mechanism of action.	Folic Acid	0-10	metaxin 1	Homo sapiens	60-63
19998340-1	2010	As a key enzyme in folate metabolism, the thymidylate synthase (TS) is important for the synthesis of nucleotides.	Folic Acid	19-25	thymidylate synthetase	Homo sapiens	42-62
19998340-1	2010	As a key enzyme in folate metabolism, the thymidylate synthase (TS) is important for the synthesis of nucleotides.	Folic Acid	19-25	thymidylate synthetase	Homo sapiens	64-66
20346029-3	2010	This genetic variant has also been discovered to confer SCC risk in nontransplant patients with low folate status.	Folic Acid	100-106	serpin family B member 3	Homo sapiens	56-59
20346029-11	2010	Such findings suggest that intervention in the form of demethylating agents or folate supplementation might be beneficial in the treatment or prevention of SCC.	Folic Acid	79-85	serpin family B member 3	Homo sapiens	156-159
20544798-10	2010	In African Americans, folate derivative levels were associated with smoking, B(12), and polymorphisms in MTR, TYMS, methionine synthase reductase (MTRR), and reduced folate carrier1 (RFC1).	Folic Acid	22-28	thymidylate synthetase	Homo sapiens	110-114
20544798-11	2010	In Caucasians, folate derivative levels were associated with vitamin use, B(12), and polymorphisms in MTHFR, TYMS, and RFC1.	Folic Acid	15-21	thymidylate synthetase	Homo sapiens	109-113
20683905-0	2010	Association of folate receptor (FOLR1, FOLR2, FOLR3) and reduced folate carrier (SLC19A1) genes with meningomyelocele.	Folic Acid	15-21	folate receptor alpha	Homo sapiens	32-37
21120433-0	2010	19-base pair deletion polymorphism of the dihydrofolate reductase (DHFR) gene: maternal risk of Down syndrome and folate metabolism.	Folic Acid	49-55	dihydrofolate reductase	Homo sapiens	67-71
21120433-2	2010	This study evaluated the influence of a 19-base pair (bp) deletion polymorphism in intron-1 of the dihydrofolate reductase (DHFR) gene on the maternal risk of DS, and investigated the association between this polymorphism and variations in the concentrations of serum folate and plasma homocysteine (Hcy) and plasma methylmalonic acid (MMA).	Folic Acid	106-112	dihydrofolate reductase	Homo sapiens	124-128
20053979-2	2010	METHODS: RT-PCR and Western blot analysis were performed in freshly isolated neural retina and RPE/eyecup, primary mouse Muller cells, and rMC-1 cells for the three known folate transport proteins folate receptor alpha (FRalpha), proton-coupled folate transporter (PCFT), and reduced folate carrier (RFC).	Folic Acid	171-177	folate receptor alpha	Rattus norvegicus	197-218
20386493-4	2010	RESULTS: RBC folate concentrations were significantly associated with MTHFR 677C&gt;T (P=0.002), MTRR 66A&gt;G (P&lt;0.0001), MTHFD1 1958G&gt;A (P=0.001) and SHMT 1420C&gt;T (P=0.012), whereas no association of these polymorphisms with disease activity was observed.	Folic Acid	13-19	serine hydroxymethyltransferase 1	Homo sapiens	158-162
19585555-0	2010	Relationship between dietary and supplemental intake of folate, methionine, vitamin B6 and folate receptor alpha expression in ovarian tumors.	Folic Acid	56-62	folate receptor alpha	Homo sapiens	91-112
19585555-1	2010	Because folate receptor alpha (FRalpha) is frequently over-expressed in epithelial ovarian tumors, we hypothesized that its association with folate may differ by FRalpha expression or by the timing of intake.	Folic Acid	8-14	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	31-38
20225891-1	2010	The proton-coupled folate transporter (PCFT) mediates intestinal folate absorption.	Folic Acid	19-25	solute carrier family 46 member 1	Homo sapiens	39-43
20037791-3	2010	We conducted a family-based case-control association study of variants in four genes involved in folate uptake and distribution: FOLR1, FPGS, GGH and SLC19A1, using 1,750 population-based and 245 clinic-based cases of pathologically confirmed colorectal cancer and their unaffected relatives participating in the Colon Cancer Family Registries.	Folic Acid	97-103	folate receptor alpha	Homo sapiens	129-134
20045418-5	2010	SIGNIFICANCE: As a component of membrane lipid raft protein complexes, these binding proteins may represent "helper" or chaperone proteins that associate with FolBp1 in order to facilitate the transport of folate across the plasma membrane.	Folic Acid	206-212	folate receptor 1 (adult)	Mus musculus	159-165
20045418-6	2010	The protein-protein interactions detected, while limited in number, may be critical in mediating the role of FolBp1 in folate transport, particularly in the developing embryo.	Folic Acid	119-125	folate receptor 1 (adult)	Mus musculus	109-115
19762432-6	2010	When assessed using MDCKII-hPCFT cells, folic acid and methotrexate were found to be high-affinity hPCFT substrates.	Folic Acid	40-50	solute carrier family 46 member 1	Homo sapiens	27-32
19762432-6	2010	When assessed using MDCKII-hPCFT cells, folic acid and methotrexate were found to be high-affinity hPCFT substrates.	Folic Acid	40-50	solute carrier family 46 member 1	Homo sapiens	99-104
19552531-7	2009	Both mRNA and protein levels of Oat1, Oat3 and Bcrp were significantly decreased in folic acid-induced acute renal failure rats.	Folic Acid	84-94	solute carrier family 22 member 8	Rattus norvegicus	38-42
19706381-0	2009	The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake.	Folic Acid	113-123	dihydrofolate reductase	Homo sapiens	44-67
19706381-3	2009	Folic acid is a synthetic oxidized form not significantly found in fresh natural foods; to be used it must be converted to tetrahydrofolate by dihydrofolate reductase (DHFR).	Folic Acid	0-10	dihydrofolate reductase	Homo sapiens	143-166
19706381-3	2009	Folic acid is a synthetic oxidized form not significantly found in fresh natural foods; to be used it must be converted to tetrahydrofolate by dihydrofolate reductase (DHFR).	Folic Acid	0-10	dihydrofolate reductase	Homo sapiens	168-172
19706381-5	2009	Here we show, using a sensitive assay we developed, that the reduction of folic acid by DHFR per gram of human liver (n = 6) obtained from organ donors or directly from surgery is, on average, less than 2% of that in rat liver at physiological pH.	Folic Acid	74-84	dihydrofolate reductase	Homo sapiens	88-92
19706161-14	2009	Genes that were normalized by folic acid played a prominent role in development, such as the transcription factors ID1 and MAFF.	Folic Acid	30-40	MAF bZIP transcription factor F	Homo sapiens	123-127
18926688-4	2009	Compound heterozygous mice (Folbp1(+/-); RFC1(+/-)) fed an adequate folate diet exhibited a reduction in plasma folate concentrations compared to heterozygous (Folbp1(+/-)) and littermate wild-type mice (P&lt;.05).	Folic Acid	112-118	folate receptor 1 (adult)	Mus musculus	28-34
19671745-1	2009	This laboratory recently identified a novel proton-coupled folate transporter (PCFT) that mediates intestinal folate absorption and transport of folates into the central nervous system.	Folic Acid	59-65	solute carrier family 46 member 1	Homo sapiens	79-83
19671745-1	2009	This laboratory recently identified a novel proton-coupled folate transporter (PCFT) that mediates intestinal folate absorption and transport of folates into the central nervous system.	Folic Acid	145-152	solute carrier family 46 member 1	Homo sapiens	79-83
19403800-1	2009	The proton-coupled folate transporter (PCFT) SLC46A1 mediates uphill folate transport into enterocytes in proximal small intestine coupled to the inwardly directed proton gradient.	Folic Acid	19-25	solute carrier family 46 member 1	Homo sapiens	39-43
19403800-1	2009	The proton-coupled folate transporter (PCFT) SLC46A1 mediates uphill folate transport into enterocytes in proximal small intestine coupled to the inwardly directed proton gradient.	Folic Acid	19-25	solute carrier family 46 member 1	Homo sapiens	45-52
19403800-2	2009	Hereditary folate malabsorption is due to loss-of-function mutations in the PCFT gene.	Folic Acid	11-17	solute carrier family 46 member 1	Homo sapiens	76-80
19403800-4	2009	D156A-, E185A-, E232A-, R148A-, and R376A-PCFT mutants lost function at pH 5.5, as assessed by transient transfection in folate transport-deficient HeLa cells.	Folic Acid	121-127	solute carrier family 46 member 1	Homo sapiens	42-46
33979572-6	2021	We showed, for the first time, that the cytotoxic effects of PGA occurred by inducing MCL1 inhibition and FBXW7 activation by blocking ELK1-SRF complex-dependent transcription.	Folic Acid	61-64	ETS transcription factor ELK1	Homo sapiens	135-139
33979572-6	2021	We showed, for the first time, that the cytotoxic effects of PGA occurred by inducing MCL1 inhibition and FBXW7 activation by blocking ELK1-SRF complex-dependent transcription.	Folic Acid	61-64	serum response factor	Homo sapiens	140-143
33979572-8	2021	These findings suggested that PGA could be a therapeutic drug candidate for the treatment of recurrent GBM by targeting the ELK1-SRF complex.	Folic Acid	30-33	ETS transcription factor ELK1	Homo sapiens	124-128
33920562-3	2021	5,10-methylene tetrahydrofolate reductase (MTHFR) is a critical enzyme in the folate metabolism pathway that converts 5,10-methylenetetrahydrofolate into 5-methyltetrahydrofolate, which produces a methyl donor for the remethylation of homocysteine to methionine.	Folic Acid	25-31	methylenetetrahydrofolate reductase	Homo sapiens	43-48
33865264-4	2021	RESULTS: The median (interquartile range) serum folate level was 7.8 (5.4 - 12.6) ng/mL in men and 10.2 (6.9 - 15.6) ng/mL in women.	Folic Acid	48-54	thrombopoietin	Mus musculus	85-87
33865264-5	2021	The reference interval for serum folate (2.5th and 97.5th percentiles) ranged from 2.9 to 38.0 ng/ mL.	Folic Acid	33-39	thrombopoietin	Mus musculus	99-101
33865264-6	2021	From among 723 Korean adults, the lower limit of reference intervals of serum folate for folate deficiency, defined as the 2.5th percentile, was 2.9 ng/mL.	Folic Acid	78-84	thrombopoietin	Mus musculus	152-154
33865264-8	2021	Using the cutoff value of 4 ng/mL for folate deficiency, which is in accordance with the instructions from the manufacturer of the new assay and the WHO 2012 guideline for homocysteine as a metabolic indicator before assay standardization, about 5% of subjects were reclassified as folate deficient.	Folic Acid	38-44	thrombopoietin	Mus musculus	31-33
32827402-5	2021	Studies involving folate supplementation for the treatment of depression have had mixed results but have omitted to take into account the genetic polymorphisms, such as the ones in methyltetrahydrofolate reductase (MTHFR), that affect folate metabolism.	Folic Acid	18-24	methylenetetrahydrofolate reductase	Homo sapiens	215-220
33672126-11	2021	Pharmacogenomic testing is being increasingly used to determine Single Nucleotide Polymorphisms in Cytochrome P450, Serotonin Transporter, COMT, folic acid conversion (MTHFR).	Folic Acid	145-155	methylenetetrahydrofolate reductase	Homo sapiens	168-173
33659047-0	2021	Folic acid supplementation acts as a chemopreventive factor in tumorigenesis of hepatocellular carcinoma by inducing H3K9Me2-dependent transcriptional repression of LCN2.	Folic Acid	0-10	lipocalin 2	Homo sapiens	165-169
33360347-10	2021	Both the antioxidants N-acetylcysteine and folic acid reversed the arsenic-mediated repression of Sp1, GDF1 and SIRT1.	Folic Acid	43-53	sirtuin 1	Danio rerio	112-117
33673278-3	2021	Here we report that transcripts for all bar two genes (i.e., BHMT, MAT1A) encoding enzymes in the linked methionine-folate cycles are expressed in all cell types within the ovarian follicle, oocyte, and blastocyst in the cow, sheep, and pig; as well as in rat granulosa cells (GCs) and human KGN cells (a granulosa-like tumor cell line).	Folic Acid	116-122	betaine--homocysteine S-methyltransferase	Bos taurus	61-65
33507728-7	2021	Key in our concept is poly(l-glutamic acid) (PGA), which serves as a hydrophilic backbone for conjugation of, respectively, peptide antigen (Ag) and an imidazoquinoline (IMDQ) TLR7/8 agonist as a molecular adjuvant.	Folic Acid	45-48	toll-like receptor 7	Mus musculus	176-182
33411826-0	2021	Acute high folic acid treatment in SH-SY5Y cells with and without MTHFR function leads to gene expression changes in epigenetic modifying enzymes, changes in epigenetic marks, and changes in dendritic spine densities.	Folic Acid	11-21	methylenetetrahydrofolate reductase	Homo sapiens	66-71
33411826-2	2021	Dietary factors such as folic acid can affect epigenetic marks using methylenetetrahydrofolate reductase (MTHFR) to metabolize folic acid to a one-carbon methyl group.	Folic Acid	24-34	methylenetetrahydrofolate reductase	Homo sapiens	69-104
33411826-2	2021	Dietary factors such as folic acid can affect epigenetic marks using methylenetetrahydrofolate reductase (MTHFR) to metabolize folic acid to a one-carbon methyl group.	Folic Acid	24-34	methylenetetrahydrofolate reductase	Homo sapiens	106-111
33411826-2	2021	Dietary factors such as folic acid can affect epigenetic marks using methylenetetrahydrofolate reductase (MTHFR) to metabolize folic acid to a one-carbon methyl group.	Folic Acid	127-137	methylenetetrahydrofolate reductase	Homo sapiens	69-104
33411826-2	2021	Dietary factors such as folic acid can affect epigenetic marks using methylenetetrahydrofolate reductase (MTHFR) to metabolize folic acid to a one-carbon methyl group.	Folic Acid	127-137	methylenetetrahydrofolate reductase	Homo sapiens	106-111
33411826-6	2021	Grouping the epigenetic modifying enzymes by function indicated that gene expression was widely affected for genes that code for enzymes affecting DNA methylation, histone acetylation, histone methylation, histone phosphorylation, and histone ubiquitination when excess folic acid treatment occurred with or without the knockdown of MTHFR.	Folic Acid	270-280	methylenetetrahydrofolate reductase	Homo sapiens	333-338
33411826-7	2021	MTHFR was significantly reduced upon excess folic acid treatment whether MTHFR was knocked-down or not.	Folic Acid	44-54	methylenetetrahydrofolate reductase	Homo sapiens	0-5
33411826-7	2021	MTHFR was significantly reduced upon excess folic acid treatment whether MTHFR was knocked-down or not.	Folic Acid	44-54	methylenetetrahydrofolate reductase	Homo sapiens	73-78
33411826-12	2021	Excess folic acid induced an increase in dendritic spines without the MTHFR knockdown, but folic acid induced a decrease in dendritic spines when MTHFR was knocked-down.	Folic Acid	91-101	methylenetetrahydrofolate reductase	Homo sapiens	146-151
33411826-14	2021	Histone 3 acetylation at lysine 18 was significantly increased when excess folic acid was applied to cells with the MTHFR knockdown, as was histone 3 phosphorylation at serine 10.	Folic Acid	75-85	methylenetetrahydrofolate reductase	Homo sapiens	116-121
33411826-15	2021	Broadly, our results indicate that excess folic acid, even with functioning MTHFR, could have detrimental effects on cells.	Folic Acid	42-52	methylenetetrahydrofolate reductase	Homo sapiens	76-81
33290257-1	2020	5,10-methylenetetrahydrofolate reductase (MTHFR) deficiency is a rare hereditary disease characterized by defects in folate and homocysteine metabolism.	Folic Acid	24-30	methylenetetrahydrofolate reductase	Homo sapiens	42-47
33290257-3	2020	MTHFR is a rate-limiting enzyme catalyzing folate production, various SNPs/mutations in the MTHFR gene have been correlated to MTHFR deficiency.	Folic Acid	43-49	methylenetetrahydrofolate reductase	Homo sapiens	0-5
33290257-3	2020	MTHFR is a rate-limiting enzyme catalyzing folate production, various SNPs/mutations in the MTHFR gene have been correlated to MTHFR deficiency.	Folic Acid	43-49	methylenetetrahydrofolate reductase	Homo sapiens	92-97
33290257-3	2020	MTHFR is a rate-limiting enzyme catalyzing folate production, various SNPs/mutations in the MTHFR gene have been correlated to MTHFR deficiency.	Folic Acid	43-49	methylenetetrahydrofolate reductase	Homo sapiens	92-97
33123371-3	2020	The gene for the enzyme 5,10-methylentetrahydrofolate reductase (MTHFR) contributes to folic acid metabolism, and polymorphisms of this gene at C677T (rs1801133) and A1298C (rs1801131) are reported to alter its enzyme activity and are suggested to be involved in CL/P development.	Folic Acid	87-97	methylenetetrahydrofolate reductase	Homo sapiens	24-63
33123371-3	2020	The gene for the enzyme 5,10-methylentetrahydrofolate reductase (MTHFR) contributes to folic acid metabolism, and polymorphisms of this gene at C677T (rs1801133) and A1298C (rs1801131) are reported to alter its enzyme activity and are suggested to be involved in CL/P development.	Folic Acid	87-97	methylenetetrahydrofolate reductase	Homo sapiens	65-70
32826232-0	2020	The Folate Cycle Enzyme MTHFR is a Critical Regulator of Cell Response to MYC-Targeting Therapies.	Folic Acid	4-10	methylenetetrahydrofolate reductase	Homo sapiens	24-29
32826232-3	2020	We establish that folate restriction and deficiency of the rate-limiting folate cycle enzyme, MTHFR - which exhibits reduced-function polymorphisms in about 10% of Caucasians - induce resistance to MYC targeting by BET and CDK7 inhibitors in cell lines, primary patient samples, and syngeneic mouse models of AML.	Folic Acid	18-24	methylenetetrahydrofolate reductase	Homo sapiens	94-99
32826232-3	2020	We establish that folate restriction and deficiency of the rate-limiting folate cycle enzyme, MTHFR - which exhibits reduced-function polymorphisms in about 10% of Caucasians - induce resistance to MYC targeting by BET and CDK7 inhibitors in cell lines, primary patient samples, and syngeneic mouse models of AML.	Folic Acid	73-79	methylenetetrahydrofolate reductase	Homo sapiens	94-99
32826232-5	2020	Mechanistically, folate cycle disturbance reduces H3K27/K9 histone methylation and activates a SPI1 transcriptional program counteracting the effect of BET inhibition.	Folic Acid	17-23	delta/notch-like EGF repeat containing	Mus musculus	152-155
32975579-6	2020	This increase of SQOR induces the downregulation of the cystathionine beta-synthase and cystathionine gamma-lyase, two enzymes of the transsulfuration pathway, the subsequent downregulation of serine biosynthesis and the adaptation of other sulfide linked pathways, such as folate cycle, nucleotides metabolism and glutathione system.	Folic Acid	274-280	cystathionine gamma-lyase	Homo sapiens	88-113
33262939-5	2020	In previous studies, we identified MTHFD2, a mitochondrial enzyme involved in folate metabolism, as a key contributor to NAD(P)H levels in the radiation-resistant cells and HNSCC tumors.	Folic Acid	78-84	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	Homo sapiens	35-41
33004416-0	2020	EBF1 and Pax5 safeguard leukemic transformation by limiting IL-7 signaling, Myc expression, and folate metabolism.	Folic Acid	96-102	paired box 5	Homo sapiens	9-13
33121283-1	2020	Objective: Although genetic variants of key enzymes in the folic acid-methionine metabolic circulation, including methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) were thought to be related to the risk of recurrent pregnancy loss (RPL), the results of recent studies have been inconsistent.	Folic Acid	59-69	methylenetetrahydrofolate reductase	Homo sapiens	114-149
33121283-1	2020	Objective: Although genetic variants of key enzymes in the folic acid-methionine metabolic circulation, including methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) were thought to be related to the risk of recurrent pregnancy loss (RPL), the results of recent studies have been inconsistent.	Folic Acid	59-69	methylenetetrahydrofolate reductase	Homo sapiens	151-156
32324263-0	2020	Folic acid rescues corticosteroid-induced vertebral malformations in chick embryos through targeting TGF-beta signaling.	Folic Acid	0-10	transforming growth factor alpha	Gallus gallus	101-109
33074454-7	2022	Folate, vitamin B6, vitamin B12, and S-adenosylmethionine (SAM) are vital cofactors involved in DNA methylation modification; 5-azacytidine (AZA) is the most widely studied DNA methyltransferase (DNMT) inhibitor, and dietary polyphenols are DNMT inhibitors in vitro.	Folic Acid	0-6	DNA methyltransferase 1	Homo sapiens	173-194
19403800-11	2009	These observations suggest that the E185 residue plays an important role in the coupled flows of protons and folate mediated by PCFT.	Folic Acid	109-115	solute carrier family 46 member 1	Homo sapiens	128-132
19389703-1	2009	This report addresses the functional role of His residues in the proton-coupled folate transporter (PCFT; SLC46A1), which mediates intestinal folate absorption.	Folic Acid	80-86	solute carrier family 46 member 1	Homo sapiens	100-104
19389703-1	2009	This report addresses the functional role of His residues in the proton-coupled folate transporter (PCFT; SLC46A1), which mediates intestinal folate absorption.	Folic Acid	80-86	solute carrier family 46 member 1	Homo sapiens	106-113
19389703-6	2009	The folic acid influx Kt for S172A-PCFT was decreased similar to H247A.	Folic Acid	4-14	solute carrier family 46 member 1	Homo sapiens	35-39
19389703-8	2009	H281A-PCFT results in loss-of-function due to approximately 12-fold upward arrow in the folic acid influx Kt.	Folic Acid	88-98	solute carrier family 46 member 1	Homo sapiens	6-10
19389703-9	2009	When the pH was decreased from 5.5 to 4.5, the WT-PCFT folic acid influx Kt was unchanged, but the Kt decreased 4-fold for H281A.	Folic Acid	55-65	solute carrier family 46 member 1	Homo sapiens	50-54
19389703-10	2009	In electrophysiological studies in Xenopus oocytes, both WT-PCFT- and H281A-PCFT-mediated folic acid uptake produced current and acidification, and both exhibited a low level of folate-independent proton transport (slippage).	Folic Acid	90-100	solute carrier family 46 member 1	Homo sapiens	60-64
19389703-10	2009	In electrophysiological studies in Xenopus oocytes, both WT-PCFT- and H281A-PCFT-mediated folic acid uptake produced current and acidification, and both exhibited a low level of folate-independent proton transport (slippage).	Folic Acid	90-100	solute carrier family 46 member 1	Homo sapiens	76-80
19389703-10	2009	In electrophysiological studies in Xenopus oocytes, both WT-PCFT- and H281A-PCFT-mediated folic acid uptake produced current and acidification, and both exhibited a low level of folate-independent proton transport (slippage).	Folic Acid	178-184	solute carrier family 46 member 1	Homo sapiens	60-64
19389703-10	2009	In electrophysiological studies in Xenopus oocytes, both WT-PCFT- and H281A-PCFT-mediated folic acid uptake produced current and acidification, and both exhibited a low level of folate-independent proton transport (slippage).	Folic Acid	178-184	solute carrier family 46 member 1	Homo sapiens	76-80
19389703-13	2009	The His281 residue is not essential for proton coupling but plays an important role in PCFT protonation, which, in turn, augments folate binding to the carrier.	Folic Acid	130-136	solute carrier family 46 member 1	Homo sapiens	87-91
19174418-0	2009	Methylenetetrahydrofolate reductase deficiency and low dietary folate reduce tumorigenesis in Apc min/+ mice.	Folic Acid	19-25	APC, WNT signaling pathway regulator	Mus musculus	94-97
19174418-7	2009	RESULTS: Apc(min/+) mice fed high folate diets from weaning developed more adenomas than those fed the folic acid-deficient diet (FADD) or the control diet (CD); Mthfr deficiency did not affect adenoma number.	Folic Acid	34-40	APC, WNT signaling pathway regulator	Mus musculus	9-12
19423536-5	2009	Among cases, but not controls, average MLH1 expression tended to be higher with current alcohol consumption, regular aspirin use, and higher total intakes of calcium, vitamin D, and folate.	Folic Acid	182-188	mutL homolog 1	Homo sapiens	39-43
20209470-1	2009	OBJECTIVE: The present paper investigates the in vitro effect of L-ascorbic acid (vitamin C), menadione sodium bisulfate (vitamin K3), and folic acid on purified lactoperoxidase (LPO).	Folic Acid	139-149	lactoperoxidase	Bos taurus	162-177
18823045-1	2009	Proton-coupled folate transporter (PCFT) has recently been identified as the molecular entity of the carrier-mediated intestinal folate transport system.	Folic Acid	15-21	solute carrier family 46 member 1	Homo sapiens	35-39
18823045-2	2009	PCFT has been demonstrated to be most abundantly expressed in the upper small intestine, localizing at the brush border membrane of epithelial cells, transport folate and its analogs more efficiently at lower (acidic) pH by a H(+)-coupled cotransport mechanism, and have a high affinity for folate with a Michaelis constant (K(m)) of a few microM at pH 5.5 and somewhat lower affinities for reduced folates and methotrexate (MTX).	Folic Acid	160-166	solute carrier family 46 member 1	Homo sapiens	0-4
18823045-2	2009	PCFT has been demonstrated to be most abundantly expressed in the upper small intestine, localizing at the brush border membrane of epithelial cells, transport folate and its analogs more efficiently at lower (acidic) pH by a H(+)-coupled cotransport mechanism, and have a high affinity for folate with a Michaelis constant (K(m)) of a few microM at pH 5.5 and somewhat lower affinities for reduced folates and methotrexate (MTX).	Folic Acid	291-297	solute carrier family 46 member 1	Homo sapiens	0-4
18823045-2	2009	PCFT has been demonstrated to be most abundantly expressed in the upper small intestine, localizing at the brush border membrane of epithelial cells, transport folate and its analogs more efficiently at lower (acidic) pH by a H(+)-coupled cotransport mechanism, and have a high affinity for folate with a Michaelis constant (K(m)) of a few microM at pH 5.5 and somewhat lower affinities for reduced folates and methotrexate (MTX).	Folic Acid	399-406	solute carrier family 46 member 1	Homo sapiens	0-4
18823045-4	2009	Thus, PCFT has all the characteristics of the brush border H(+)-coupled cotransporter for folate and analogs, which has long been suggested to be present in the intestine.	Folic Acid	90-96	solute carrier family 46 member 1	Homo sapiens	6-10
19131550-1	2009	Folylpoly-gamma-gluatamate synthetase (FPGS) catalyzes the polyglutamylation and thus intracellular retention of folates and antifolates (eg, methotrexate; MTX) through the addition of multiple glutamate equivalents to their gamma-carboxyl residue.	Folic Acid	113-120	folylpolyglutamate synthase	Homo sapiens	0-37
19131550-1	2009	Folylpoly-gamma-gluatamate synthetase (FPGS) catalyzes the polyglutamylation and thus intracellular retention of folates and antifolates (eg, methotrexate; MTX) through the addition of multiple glutamate equivalents to their gamma-carboxyl residue.	Folic Acid	113-120	folylpolyglutamate synthase	Homo sapiens	39-43
19131550-1	2009	Folylpoly-gamma-gluatamate synthetase (FPGS) catalyzes the polyglutamylation and thus intracellular retention of folates and antifolates (eg, methotrexate; MTX) through the addition of multiple glutamate equivalents to their gamma-carboxyl residue.	Folic Acid	113-120	metaxin 1	Homo sapiens	156-159
19074442-2	2009	PCFT is critical to intestinal folate absorption and transport into the central nervous system because there are loss-of-function mutations in this gene in the autosomal recessive disorder, hereditary folate malabsorption.	Folic Acid	31-37	solute carrier family 46 member 1	Homo sapiens	0-4
35602963-5	2022	Crystal structures of GA derivatives indicate that GA occupies SHMT2 folate-binding pocket and regulates SHMT2 activity.	Folic Acid	69-75	serine hydroxymethyltransferase 2	Homo sapiens	63-68
19074442-5	2009	FRalpha was shown to bind and trap folates in vesicles but with minimal export into the cytosol in PCFT(-) cells.	Folic Acid	35-42	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	0-7
19074442-6	2009	Cotransfection of FRalpha and PCFT resulted in enhanced folate transport into cytosol as compared with transfection of FRalpha alone.	Folic Acid	56-62	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	18-25
19074442-6	2009	Cotransfection of FRalpha and PCFT resulted in enhanced folate transport into cytosol as compared with transfection of FRalpha alone.	Folic Acid	56-62	solute carrier family 46 member 1	Homo sapiens	30-34
19074442-9	2009	These observations (i) indicate that PCFT plays a role in FRalpha-mediated endocytosis by serving as a route of export of folates from acidified endosomes and (ii) provide a functional role for PCFT in tissues in which it is expressed, such as the choroid plexus, where the extracellular milieu is at neutral pH.	Folic Acid	122-129	solute carrier family 46 member 1	Homo sapiens	37-41
35507584-5	2022	In this study, a folate (FA) moiety ligand-conjugated poly(sorbitol-co-PEI)-based gene transporter was designed by combining low-molecular weight polyethyleneimine (LMW PEI) and D-sorbitol with FA to form FPS.	Folic Acid	17-23	farnesyl diphosphate synthase	Homo sapiens	205-208
19074442-9	2009	These observations (i) indicate that PCFT plays a role in FRalpha-mediated endocytosis by serving as a route of export of folates from acidified endosomes and (ii) provide a functional role for PCFT in tissues in which it is expressed, such as the choroid plexus, where the extracellular milieu is at neutral pH.	Folic Acid	122-129	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	58-65
35190897-0	2022	Folate ameliorates homocysteine-induced osteoblast dysfunction by reducing endoplasmic reticulum stress-activated PERK/ATF-4/CHOP pathway in MC3T3-E1 cells.	Folic Acid	0-6	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	114-118
18851711-1	2009	In contrast with most species, including humans, which have monofunctional forms of the folate biosynthetic enzymes TS (thymidylate synthase) and DHFR (dihydrofolate reductase), several pathogenic protozoal parasites, including Cryptosporidium hominis, contain a bifunctional form of the enzymes on a single polypeptide chain having both catalytic activities.	Folic Acid	88-94	thymidylate synthetase	Homo sapiens	120-140
35459281-5	2022	Multivariable linear regression models were adopted to investigate the serum lead and cadmium levels and RBC folate concentration.	Folic Acid	109-115	RNA, 7SL, cytoplasmic 263, pseudogene	Homo sapiens	105-108
18851711-1	2009	In contrast with most species, including humans, which have monofunctional forms of the folate biosynthetic enzymes TS (thymidylate synthase) and DHFR (dihydrofolate reductase), several pathogenic protozoal parasites, including Cryptosporidium hominis, contain a bifunctional form of the enzymes on a single polypeptide chain having both catalytic activities.	Folic Acid	88-94	dihydrofolate reductase	Homo sapiens	146-150
35459281-6	2022	A significant reverse relationship was found between serum lead and cadmium and RBC folate.	Folic Acid	84-90	RNA, 7SL, cytoplasmic 263, pseudogene	Homo sapiens	80-83
35459281-7	2022	A negative relationship between serum lead and cadmium levels and the levels of RBC folate in the U.S. adult population was found in this study.	Folic Acid	84-90	RNA, 7SL, cytoplasmic 263, pseudogene	Homo sapiens	80-83
18851711-1	2009	In contrast with most species, including humans, which have monofunctional forms of the folate biosynthetic enzymes TS (thymidylate synthase) and DHFR (dihydrofolate reductase), several pathogenic protozoal parasites, including Cryptosporidium hominis, contain a bifunctional form of the enzymes on a single polypeptide chain having both catalytic activities.	Folic Acid	88-94	dihydrofolate reductase	Homo sapiens	152-175
19146480-1	2009	Plasmodium falciparum thymidylate synthase-dihydrofolate reductase (TS-DHFR) is an essential enzyme in folate biosynthesis and a major malarial drug target.	Folic Acid	50-56	dihydrofolate reductase	Homo sapiens	71-75
35065481-4	2022	This work was based on the steric hindrance caused by binding between FR and folate to regulate cleavage of folate-T30 by exonuclease I (Exo I) and to inhibit subsequent polymerization and extension reaction of the cleavage product by terminal deoxynucleotidyl transferase (TdT).	Folic Acid	77-83	DNA nucleotidylexotransferase	Homo sapiens	235-272
19010378-7	2009	Further work in this direction suggested that cytotoxic interaction between folate deficiency and gamma radiation might induce utilization of choline and choline containing moieties by modifying levels of key regulatory enzymes dihydrofolate reductase (DHFR) and choline oxidase (ChoOx).	Folic Acid	76-82	dihydrofolate reductase	Homo sapiens	228-251
35065481-4	2022	This work was based on the steric hindrance caused by binding between FR and folate to regulate cleavage of folate-T30 by exonuclease I (Exo I) and to inhibit subsequent polymerization and extension reaction of the cleavage product by terminal deoxynucleotidyl transferase (TdT).	Folic Acid	77-83	DNA nucleotidylexotransferase	Homo sapiens	274-277
35065481-4	2022	This work was based on the steric hindrance caused by binding between FR and folate to regulate cleavage of folate-T30 by exonuclease I (Exo I) and to inhibit subsequent polymerization and extension reaction of the cleavage product by terminal deoxynucleotidyl transferase (TdT).	Folic Acid	108-114	DNA nucleotidylexotransferase	Homo sapiens	235-272
35065481-4	2022	This work was based on the steric hindrance caused by binding between FR and folate to regulate cleavage of folate-T30 by exonuclease I (Exo I) and to inhibit subsequent polymerization and extension reaction of the cleavage product by terminal deoxynucleotidyl transferase (TdT).	Folic Acid	108-114	DNA nucleotidylexotransferase	Homo sapiens	274-277
35417465-3	2022	Our current work aimd to explore the possible ameliorative potency of folic acid and its association with the hepatic miR-21, -34a, and -122 expression as well as their targeted genes, HBP1, SIRT1, and SREBP-1c in rats with non-alcoholic fatty liver disease (NAFL).	Folic Acid	70-80	microRNA 21	Rattus norvegicus	118-124
35417465-11	2022	In conclusions, the anti-steatotic, insulin-sensitizing, glucose-lowering and lipotropic potencies of folic acid in NAFL rats may be linked to the epigenetic modulation of the hepatic microRNAs (miR-21, -34a, and -122) and the expression of their target genes (HBP1, SIRT1, and SREBP-1c).	Folic Acid	102-112	microRNA 21	Rattus norvegicus	195-201
19010378-7	2009	Further work in this direction suggested that cytotoxic interaction between folate deficiency and gamma radiation might induce utilization of choline and choline containing moieties by modifying levels of key regulatory enzymes dihydrofolate reductase (DHFR) and choline oxidase (ChoOx).	Folic Acid	76-82	dihydrofolate reductase	Homo sapiens	253-257
19227476-4	2009	Covalent attachment of folate to the lysine side chain amino groups was used to reroute the LDL from its natural receptor (LDLR) to folate receptors and could be utilized to target other receptors.	Folic Acid	23-29	low density lipoprotein receptor	Homo sapiens	123-127
19116913-10	2009	CONCLUSION: Abundant FRbeta expression on activated macrophages in synovial tissue from RA patients deserves further exploration for selective therapeutic interventions with high-affinity-binding folate antagonists, of which BCG 945 may be a prototypical representative.	Folic Acid	196-202	folate receptor beta	Homo sapiens	21-27
18669903-2	2008	We hypothesized that if folate pathway inhibition is the mechanism of cancer preventive activities of EGCG, then the protective effect against breast cancer would be stronger among women with low dietary folate intake and the high-activity methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TYMS) genotypes.	Folic Acid	24-30	thymidylate synthetase	Homo sapiens	288-308
18669903-2	2008	We hypothesized that if folate pathway inhibition is the mechanism of cancer preventive activities of EGCG, then the protective effect against breast cancer would be stronger among women with low dietary folate intake and the high-activity methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TYMS) genotypes.	Folic Acid	24-30	thymidylate synthetase	Homo sapiens	310-314
18458991-0	2008	Thymidylate synthase genotype and serum concentrations of homocysteine and folate in Behcet"s disease.	Folic Acid	75-81	thymidylate synthetase	Homo sapiens	0-20
19001765-0	2008	Effects of folate on notch signaling and cell proliferation in neural stem cells of neonatal rats in vitro.	Folic Acid	11-17	notch receptor 1	Rattus norvegicus	21-26
19001765-1	2008	The aim of the present study was to determine if folate alters Notch signaling and cell proliferation in neural stem cells (NSCs).	Folic Acid	49-55	notch receptor 1	Rattus norvegicus	63-68
19001765-11	2008	These results suggest that NSCs cultured from neonatal rats respond to folate with altered Notch signaling and increased cell proliferation.	Folic Acid	71-77	notch receptor 1	Rattus norvegicus	91-96
18724364-3	2008	Kinetic flux profiling with (15)N-labeled ammonia in Escherichia coli reveals that trimethoprim leads to blockade not only of DHFR but also of another critical enzyme of folate metabolism: folylpoly-gamma-glutamate synthetase (FP-gamma-GS).	Folic Acid	170-176	Dihydrofolate reductase	Escherichia coli	126-130
18339680-2	2008	We investigated whether dietary folate, vitamin B2 and vitamin B6, methionine and alcohol were associated with mutL homologue 1 (MLH1) hypermethylation and the related molecular phenotypes of MLH1 protein expression, microsatellite instability (MSI) and BRAF mutations in patients with colorectal carcinomas.	Folic Acid	32-38	mutL homolog 1	Homo sapiens	111-127
18339680-2	2008	We investigated whether dietary folate, vitamin B2 and vitamin B6, methionine and alcohol were associated with mutL homologue 1 (MLH1) hypermethylation and the related molecular phenotypes of MLH1 protein expression, microsatellite instability (MSI) and BRAF mutations in patients with colorectal carcinomas.	Folic Acid	32-38	mutL homolog 1	Homo sapiens	129-133
18470605-7	2008	There was a dose-dependent reduction in the rate of cardiac myocyte apoptosis in the folic acid groups (P &lt; 0.01), and this was accompanied by an increased level of anti-apoptotic protein Bcl-2 and decreased level of pro-apoptotic protein Bax and Fas (P &lt; 0.01).	Folic Acid	85-95	BCL2 associated X, apoptosis regulator	Rattus norvegicus	242-245
18599958-1	2008	When maintained on a folate-deficient, iron-rich diet, transgenic mice lacking in apolipoprotein E (ApoE-/- mice) demonstrate impaired activity of glutathione S-transferase (GST), resulting in increased oxidative species within brain tissue despite abnormally high levels of glutathione.	Folic Acid	21-27	hematopoietic prostaglandin D synthase	Mus musculus	147-172
18599958-1	2008	When maintained on a folate-deficient, iron-rich diet, transgenic mice lacking in apolipoprotein E (ApoE-/- mice) demonstrate impaired activity of glutathione S-transferase (GST), resulting in increased oxidative species within brain tissue despite abnormally high levels of glutathione.	Folic Acid	21-27	hematopoietic prostaglandin D synthase	Mus musculus	174-177
18405659-1	2008	The human proton-coupled folate transporter (HsPCFT, SLC46A1) mediates intestinal absorption of folates and transport of folates into the liver, brain and other tissues.	Folic Acid	96-103	solute carrier family 46 member 1	Homo sapiens	53-60
18405659-1	2008	The human proton-coupled folate transporter (HsPCFT, SLC46A1) mediates intestinal absorption of folates and transport of folates into the liver, brain and other tissues.	Folic Acid	121-128	solute carrier family 46 member 1	Homo sapiens	53-60
19003167-3	2008	Methotrexate, a widely prescribed pharmaceutical which inhibits dihydrofolate reductase and therefore folate metabolism, is known to cause teratogenic effects in human fetuses.	Folic Acid	71-77	Pyrroline 5-carboyxlate reductase	Drosophila melanogaster	78-87
18400109-12	2008	CONCLUSION: Inactivation of RFC1 impacts the expression of several ligands and interacting proteins in the cubilin-amnionless-megalin complex that are involved in the maternal-fetal transport of folate and other nutrients, lipids and morphogens such as sonic hedgehog (Shh) and retinoids that play critical roles in normal embryogenesis.	Folic Acid	195-201	sonic hedgehog signaling molecule	Homo sapiens	269-272
18247058-0	2008	An insertion/deletion polymorphism of the dihydrofolate reductase (DHFR) gene is associated with serum and red blood cell folate concentrations in women.	Folic Acid	49-55	dihydrofolate reductase	Homo sapiens	67-71
18247058-3	2008	Dihydrofolate reductase catalyzes the reduction of folic acid to dihydrofolate and thereafter to tetrahydrofolate.	Folic Acid	51-61	dihydrofolate reductase	Homo sapiens	0-23
18342661-1	2008	Folate receptor alpha (FRalpha) has emerged as a potential cancer therapy target with several folate-linked therapeutic agents currently undergoing clinical trials.	Folic Acid	94-100	folate receptor alpha	Homo sapiens	0-21
18342661-1	2008	Folate receptor alpha (FRalpha) has emerged as a potential cancer therapy target with several folate-linked therapeutic agents currently undergoing clinical trials.	Folic Acid	94-100	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	23-30
18342661-11	2008	Thus, our data show that there is selective expression of FRalpha in some colorectal cancers, providing a foundation for investigating the use of folate conjugates for imaging and therapy of colorectal tumors.	Folic Acid	146-152	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	58-65
18222534-11	2008	New findings from this study show that FRalpha expression is maintained on metastatic foci and recurrent tumors, suggesting that novel folate-targeted therapies may hold promise for the majority of women with either newly diagnosed or recurrent ovarian cancer.	Folic Acid	135-141	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	39-46
18256483-4	2008	In the first part of the study, the expression levels of the mRNA of the folate receptor alpha (FRalpha), the reduced folate carrier (RFC), and heme carrier protein 1 (HCP1) were determined in BeWo cells by RT-PCR analysis.	Folic Acid	73-79	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	96-103
17660957-11	2008	Furthermore, the present findings suggest that reduced-folate administration only influences methotrexate disposition in males, with the renal reduced-folate response influenced by OAT3 function.	Folic Acid	151-157	solute carrier family 22 (organic anion transporter), member 8	Mus musculus	181-185
18171026-1	2008	Gamma-glutamyl hydrolase, a cysteine peptidase, catalyzes the hydrolysis of poly-gamma-glutamate derivatives of folate cofactors and many antifolate drugs.	Folic Acid	112-118	gamma-glutamyl hydrolase	Homo sapiens	0-24
18804701-4	2008	gamma-Glutamyl hydrolase (GH) catalyzes the hydrolysis of the oligo-gamma-glutamates derivatives to monoglutamyl forms, which are substrates for the reduced folate carrier and able to exit the cell.	Folic Acid	157-163	gamma-glutamyl hydrolase	Homo sapiens	0-24
18804701-4	2008	gamma-Glutamyl hydrolase (GH) catalyzes the hydrolysis of the oligo-gamma-glutamates derivatives to monoglutamyl forms, which are substrates for the reduced folate carrier and able to exit the cell.	Folic Acid	157-163	gamma-glutamyl hydrolase	Homo sapiens	26-28
18804701-7	2008	The fluoroglutamic acids and fluoroglutamate-containing folates and antifolates exhibit position-dependent effects on the reactions catalyzed by FPGS and GH, thus providing insight into the catalytic mechanism and control of these enzymes.	Folic Acid	56-63	folylpolyglutamate synthase	Homo sapiens	145-149
18804701-7	2008	The fluoroglutamic acids and fluoroglutamate-containing folates and antifolates exhibit position-dependent effects on the reactions catalyzed by FPGS and GH, thus providing insight into the catalytic mechanism and control of these enzymes.	Folic Acid	56-63	gamma-glutamyl hydrolase	Homo sapiens	154-156
17961509-6	2007	These results support an in vivo role for mouse Nat2/human NAT1 in folate metabolism.	Folic Acid	67-73	N-acetyltransferase 1	Homo sapiens	59-63
17921385-2	2007	OBJECTIVE: We tested the hypothesis that biomarkers of folate and vitamin B-12 status are associated with estrogen receptor alpha (ERalpha) and mutL homolog 1 (MLH1) promoter methylation in subjects with and without neoplasia.	Folic Acid	55-61	mutL homolog 1	Homo sapiens	144-158
17921385-2	2007	OBJECTIVE: We tested the hypothesis that biomarkers of folate and vitamin B-12 status are associated with estrogen receptor alpha (ERalpha) and mutL homolog 1 (MLH1) promoter methylation in subjects with and without neoplasia.	Folic Acid	55-61	mutL homolog 1	Homo sapiens	160-164
17868882-0	2007	Folic acid reduces chemokine MCP-1 release and expression in rats with hyperhomocystinemia.	Folic Acid	0-10	C-C motif chemokine ligand 2	Rattus norvegicus	29-34
17868882-1	2007	OBJECTIVE: This study aimed to investigate the effects of folate on the monocyte chemoattractant protein-1 (MCP-1) expression and release in rats with hyperhomocystinemia induced by ingestion of excess methionine.	Folic Acid	58-64	C-C motif chemokine ligand 2	Rattus norvegicus	72-106
17868882-1	2007	OBJECTIVE: This study aimed to investigate the effects of folate on the monocyte chemoattractant protein-1 (MCP-1) expression and release in rats with hyperhomocystinemia induced by ingestion of excess methionine.	Folic Acid	58-64	C-C motif chemokine ligand 2	Rattus norvegicus	108-113
17868882-7	2007	(d) Most important, after folic acid supplementation, the lowering of Hcy levels was accompanied by a marked reduction of MCP-1 expressed in aortae and released from plasma and peripheral blood mononuclear cells (PBMCs) stimulated by oxidized low-density lipoprotein (P&lt;.05, P&lt;.01).	Folic Acid	26-36	C-C motif chemokine ligand 2	Rattus norvegicus	122-127
17868882-8	2007	CONCLUSION: Folic acid supplementation not only can blunt the rise in Hcy and reduce MCP-1 released from both plasma and PBMCs of rats with hyperhomocystinemia but also can downgrade MCP-1 expression in the aorta of rats with hyperhomocystinemia.	Folic Acid	12-22	C-C motif chemokine ligand 2	Rattus norvegicus	85-90
17868882-8	2007	CONCLUSION: Folic acid supplementation not only can blunt the rise in Hcy and reduce MCP-1 released from both plasma and PBMCs of rats with hyperhomocystinemia but also can downgrade MCP-1 expression in the aorta of rats with hyperhomocystinemia.	Folic Acid	12-22	C-C motif chemokine ligand 2	Rattus norvegicus	183-188
17113224-1	2007	Thymidylate synthase and serine hydroxymethyltransferase are involved in folate metabolism.	Folic Acid	73-79	thymidylate synthetase	Homo sapiens	0-20
17473184-8	2007	Among the transfected 143B sublines, only the 143B-FR alpha was able to uptake 5-methyltetrahydrofolate when the extracellular concentration was reduced to 2 nmol/L, which conferred a growth advantage in physiologic folate concentrations compared with vector-only-transfected cells.	Folic Acid	97-103	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	51-59
16963246-5	2007	In contrast, there were no differences in adenoma formation between Apc(min/+) mice carrying a knockout allele for methionine synthase (Mtr(+/-)), an enzyme that catalyzes folate-dependent homocysteine remethylation, and Mtr(+/+)Apc(min/+) mice.	Folic Acid	172-178	5-methyltetrahydrofolate-homocysteine methyltransferase	Mus musculus	115-134
17449573-4	2007	We determined the respective roles of GCPII and gamma-GH in dietary folate hydrolysis in rat small intestine.	Folic Acid	68-74	folate hydrolase 1	Rattus norvegicus	38-43
17336564-1	2007	The dihydrofolate reductase (DHFR) enzyme is important for folate availability, folate turnover and DNA synthesis.	Folic Acid	11-17	dihydrofolate reductase	Homo sapiens	29-33
17336564-1	2007	The dihydrofolate reductase (DHFR) enzyme is important for folate availability, folate turnover and DNA synthesis.	Folic Acid	59-65	dihydrofolate reductase	Homo sapiens	4-27
17336564-1	2007	The dihydrofolate reductase (DHFR) enzyme is important for folate availability, folate turnover and DNA synthesis.	Folic Acid	59-65	dihydrofolate reductase	Homo sapiens	29-33
18067451-5	2007	Folr1 nullizygous mice also exhibit orofacial clefts when the dams are provided with low folate supplementation during pregnancy.	Folic Acid	89-95	folate receptor 1 (adult)	Mus musculus	0-5
18067453-5	2007	Previously, we demonstrated that cSHMT-derived folate activated one-carbon units are preferentially incorporated into thymidylate, and we provided evidence that this was achieved through modification with small ubiquitin-like modifier (SUMO) enabling SUMO-dependent nuclear localization of cSHMT during S-phase.	Folic Acid	47-53	serine hydroxymethyltransferase 1	Homo sapiens	33-38
18067453-5	2007	Previously, we demonstrated that cSHMT-derived folate activated one-carbon units are preferentially incorporated into thymidylate, and we provided evidence that this was achieved through modification with small ubiquitin-like modifier (SUMO) enabling SUMO-dependent nuclear localization of cSHMT during S-phase.	Folic Acid	47-53	serine hydroxymethyltransferase 1	Homo sapiens	290-295
17171786-7	2006	Decreased expression and methylation of c-myc accompanied higher folate concentrations.	Folic Acid	65-71	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	40-45
17171786-11	2006	CONCLUSION: Lower folate levels in gastric mucosal tissue may confer a higher risk of gastric carcinogenesis through hypomethylation and overexpression of c-myc.	Folic Acid	18-24	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	155-160
17129779-6	2006	However, the current study establishes that a major function of this gene product is proton-coupled folate transport required for folate homeostasis in man, and we have thus amended the name to PCFT/HCP1.	Folic Acid	100-106	solute carrier family 46 member 1	Homo sapiens	194-203
33074454-7	2022	Folate, vitamin B6, vitamin B12, and S-adenosylmethionine (SAM) are vital cofactors involved in DNA methylation modification; 5-azacytidine (AZA) is the most widely studied DNA methyltransferase (DNMT) inhibitor, and dietary polyphenols are DNMT inhibitors in vitro.	Folic Acid	0-6	DNA methyltransferase 1	Homo sapiens	196-200
33074454-7	2022	Folate, vitamin B6, vitamin B12, and S-adenosylmethionine (SAM) are vital cofactors involved in DNA methylation modification; 5-azacytidine (AZA) is the most widely studied DNA methyltransferase (DNMT) inhibitor, and dietary polyphenols are DNMT inhibitors in vitro.	Folic Acid	0-6	DNA methyltransferase 1	Homo sapiens	241-245
33111012-2	2020	The system comprised of the FR ligand folic acid (FA), glycine-phenylalanine-leucine-glycine (Gly-Phe-Leu-Gly, GFLG), which can be specifically cleaved by cathepsin B, and the anticancer drug mitomycin C (MMC).	Folic Acid	38-48	cathepsin B	Homo sapiens	155-166
32929075-0	2020	MT1DP loaded by folate-modified liposomes sensitizes erastin-induced ferroptosis via regulating miR-365a-3p/NRF2 axis in non-small cell lung cancer cells.	Folic Acid	16-22	metallothionein 1D, pseudogene	Homo sapiens	0-5
32929075-6	2020	As low solubility of erastin limits its efficient application, we further prepared folate (FA)-modified liposome (FA-LP) nanoparticles for targeted co-delivery of erastin and MT1DP to enhance the bioavailability and the efficiency of the drug/gene combination.	Folic Acid	83-89	metallothionein 1D, pseudogene	Homo sapiens	175-180
32887268-5	2020	Since 5,10-methylenetetrahydrofolate reductase (MTHFR) is the key enzyme in the biosynthesis of an active folate form, we evaluated the relevance of polymorphisms in the MTHFR gene on intracellular levels of bioactive metabolite, the 5-methyltetrahydrofolate (5-Me-THF).	Folic Acid	30-36	methylenetetrahydrofolate reductase	Homo sapiens	48-53
32887268-5	2020	Since 5,10-methylenetetrahydrofolate reductase (MTHFR) is the key enzyme in the biosynthesis of an active folate form, we evaluated the relevance of polymorphisms in the MTHFR gene on intracellular levels of bioactive metabolite, the 5-methyltetrahydrofolate (5-Me-THF).	Folic Acid	30-36	methylenetetrahydrofolate reductase	Homo sapiens	170-175
32864099-5	2020	Higher doses of folic acid may be needed for patients with the T allele of MTHFR, so it may not be sufficient to give vitamin B12 (methylcobalamin) alone, even in countries with folate fortification.	Folic Acid	16-26	methylenetetrahydrofolate reductase	Homo sapiens	75-80
32820034-4	2021	Functional analysis indicates that CIC binds to an octameric sequence in the promoter regions of folate transport genes: FOLR1, PCFT and reduced folate carrier (Slc19A1; RFC1).	Folic Acid	97-103	replication factor C subunit 1	Homo sapiens	170-174
32543769-2	2020	Folate transport across biological membranes is mediated by three major pathways: folate receptor alpha (FRalpha), proton-coupled folate transporter (PCFT), and reduced folate carrier (RFC).	Folic Acid	0-6	solute carrier family 46, member 1	Mus musculus	115-148
32543769-2	2020	Folate transport across biological membranes is mediated by three major pathways: folate receptor alpha (FRalpha), proton-coupled folate transporter (PCFT), and reduced folate carrier (RFC).	Folic Acid	0-6	solute carrier family 46, member 1	Mus musculus	150-154
32543769-2	2020	Folate transport across biological membranes is mediated by three major pathways: folate receptor alpha (FRalpha), proton-coupled folate transporter (PCFT), and reduced folate carrier (RFC).	Folic Acid	0-6	solute carrier family 19 (folate transporter), member 1	Mus musculus	161-183
32543769-2	2020	Folate transport across biological membranes is mediated by three major pathways: folate receptor alpha (FRalpha), proton-coupled folate transporter (PCFT), and reduced folate carrier (RFC).	Folic Acid	0-6	solute carrier family 19 (folate transporter), member 1	Mus musculus	185-188
32543769-3	2020	Brain folate transport primarily occurs at the choroid plexus through FRalpha and PCFT; inactivation of these transport systems results in suboptimal folate levels in the cerebrospinal fluid (CSF) causing childhood neurological disorders.	Folic Acid	6-12	solute carrier family 46, member 1	Mus musculus	82-86
32543769-4	2020	Our group has reported that upregulation of RFC at the blood-brain barrier (BBB) through interactions with specific transcription factors, that is, vitamin D receptor (VDR) could increase brain folate delivery.	Folic Acid	194-200	solute carrier family 19 (folate transporter), member 1	Mus musculus	44-47
32543769-4	2020	Our group has reported that upregulation of RFC at the blood-brain barrier (BBB) through interactions with specific transcription factors, that is, vitamin D receptor (VDR) could increase brain folate delivery.	Folic Acid	194-200	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	148-166
32543769-4	2020	Our group has reported that upregulation of RFC at the blood-brain barrier (BBB) through interactions with specific transcription factors, that is, vitamin D receptor (VDR) could increase brain folate delivery.	Folic Acid	194-200	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	168-171
32601218-0	2020	Folate stress induces SLX1- and RAD51-dependent mitotic DNA synthesis at the fragile X locus in human cells.	Folic Acid	0-6	RAD51 recombinase	Homo sapiens	32-37
32203239-11	2020	DNA methylation of MTHFR, MTR, and MTRR was also significantly associated with folate treatment response (P < 0.001).	Folic Acid	79-85	methylenetetrahydrofolate reductase	Homo sapiens	19-24
32653772-9	2020	After adjusting for potential confounders, this association remained significant with total folate (beta = 2.0, P < .001) and red blood cell folate (beta = 1.8, P < .001), but not with plasma folate (beta = 0.2, P = .34).	Folic Acid	141-147	immunoglobulin kappa variable 2D-30	Homo sapiens	149-157
32653772-9	2020	After adjusting for potential confounders, this association remained significant with total folate (beta = 2.0, P < .001) and red blood cell folate (beta = 1.8, P < .001), but not with plasma folate (beta = 0.2, P = .34).	Folic Acid	141-147	immunoglobulin kappa variable 2D-30	Homo sapiens	149-157
33544785-6	2020	Methylenetetrahydrofolate reductase (MTHFR) gene codes the enzyme involved in the intracellular metabolism of folic acid; the 677C-T polymorphism of this gene causes the thermolability of the enzyme and decreased enzymatic activity, which is also dependent of folate plasmatic level.	Folic Acid	110-120	methylenetetrahydrofolate reductase	Homo sapiens	0-35
33544785-6	2020	Methylenetetrahydrofolate reductase (MTHFR) gene codes the enzyme involved in the intracellular metabolism of folic acid; the 677C-T polymorphism of this gene causes the thermolability of the enzyme and decreased enzymatic activity, which is also dependent of folate plasmatic level.	Folic Acid	110-120	methylenetetrahydrofolate reductase	Homo sapiens	37-42
33544785-6	2020	Methylenetetrahydrofolate reductase (MTHFR) gene codes the enzyme involved in the intracellular metabolism of folic acid; the 677C-T polymorphism of this gene causes the thermolability of the enzyme and decreased enzymatic activity, which is also dependent of folate plasmatic level.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
32223781-1	2020	OBJECTIVE: There is limited evidence on the interaction by alcohol dehydrogenase 2 (ADH1B) (rs1229984) and aldehyde dehydrogenase 2 (ALDH2) (rs671) regarding the associations of alcohol and a methyl diet (low folate and high alcohol intake) with cancer risk, partly because of rare polymorphisms in Western populations.	Folic Acid	209-215	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	84-89
31918266-3	2020	OBJECTIVES: The purpose of this study was to conduct an integrated analysis of miR expression in squamous cell carcinoma tissues with adequate or deficient serum folate.	Folic Acid	162-168	membrane associated ring-CH-type finger 8	Homo sapiens	79-82
32019154-0	2020	Food Intervention with Folate Reduces TNF-alpha and Interleukin Levels in Overweight and Obese Women with the MTHFR C677T Polymorphism: A Randomized Trial.	Folic Acid	23-29	methylenetetrahydrofolate reductase	Homo sapiens	110-115
31941442-9	2020	Folic acid treatment effectively increased the levels of monoamine neurotransmitters, BDNF and beta-endorphin, interleukin-6 and homocysteine levels were also significantly suppressed by folic acid administration.	Folic Acid	0-10	brain-derived neurotrophic factor	Rattus norvegicus	86-90
31941442-9	2020	Folic acid treatment effectively increased the levels of monoamine neurotransmitters, BDNF and beta-endorphin, interleukin-6 and homocysteine levels were also significantly suppressed by folic acid administration.	Folic Acid	187-197	brain-derived neurotrophic factor	Rattus norvegicus	86-90
17129779-6	2006	However, the current study establishes that a major function of this gene product is proton-coupled folate transport required for folate homeostasis in man, and we have thus amended the name to PCFT/HCP1.	Folic Acid	130-136	solute carrier family 46 member 1	Homo sapiens	194-203
17183144-6	2006	Herein, we demonstrate that dietary deficiency in folate and vitamin E increased PS-1 expression in juvenile and adult normal C57B1/6J and ApoE-/- mice and in aged normal mice.	Folic Acid	50-56	presenilin 1	Mus musculus	81-85
16997330-1	2006	We have studied the effect of genetic polymorphisms in the DNA repair genes hOGG1, XRCC1, XRCC3, ERCC2 and the MTHFR gene in the folate metabolism on the frequencies of cells with chromosomal aberrations (CA), chromosome-type aberrations (CSA), chromatid-type aberrations (CTA), chromatid breaks (CTB) and chromatid gaps (CTG) scored in peripheral blood lymphocytes from 651 Norwegian subjects of Caucasian descendant.	Folic Acid	129-135	8-oxoguanine DNA glycosylase	Homo sapiens	76-81
16945597-1	2006	Human gamma-glutamyl hydrolase (hGH) is a key enzyme in the metabolism of folic acid and in the pharmacology of many antifolate drugs.	Folic Acid	74-84	gamma-glutamyl hydrolase	Homo sapiens	6-30
17092765-8	2006	While the mechanism of cellular retention of (anti)folates is mediated via (anti)folylpolyglutamylation, certain efflux transporters including MRP5 (ABCC5) and BCRP were shown to transport both mono-, di- as well as triglutamate derivatives of MTX and folic acid.	Folic Acid	51-58	ATP binding cassette subfamily C member 5	Rattus norvegicus	143-147
17092765-8	2006	While the mechanism of cellular retention of (anti)folates is mediated via (anti)folylpolyglutamylation, certain efflux transporters including MRP5 (ABCC5) and BCRP were shown to transport both mono-, di- as well as triglutamate derivatives of MTX and folic acid.	Folic Acid	51-58	ATP binding cassette subfamily C member 5	Rattus norvegicus	149-154
17092765-8	2006	While the mechanism of cellular retention of (anti)folates is mediated via (anti)folylpolyglutamylation, certain efflux transporters including MRP5 (ABCC5) and BCRP were shown to transport both mono-, di- as well as triglutamate derivatives of MTX and folic acid.	Folic Acid	252-262	ATP binding cassette subfamily C member 5	Rattus norvegicus	143-147
17092765-8	2006	While the mechanism of cellular retention of (anti)folates is mediated via (anti)folylpolyglutamylation, certain efflux transporters including MRP5 (ABCC5) and BCRP were shown to transport both mono-, di- as well as triglutamate derivatives of MTX and folic acid.	Folic Acid	252-262	ATP binding cassette subfamily C member 5	Rattus norvegicus	149-154
16680433-2	2006	N-acetyltransferase 1 (NAT1) participates in the catabolism of folates and the acetylation of aromatic and heterocyclic amines.	Folic Acid	63-70	N-acetyltransferase 1	Homo sapiens	0-21
16680433-2	2006	N-acetyltransferase 1 (NAT1) participates in the catabolism of folates and the acetylation of aromatic and heterocyclic amines.	Folic Acid	63-70	N-acetyltransferase 1	Homo sapiens	23-27
16680433-3	2006	Hence, functional polymorphisms in NAT1, the gene encoding NAT1, could influence the risk of spina bifida via either folate catabolism or acetylation of exogenous agents.	Folic Acid	117-123	N-acetyltransferase 1	Homo sapiens	35-39
16680433-3	2006	Hence, functional polymorphisms in NAT1, the gene encoding NAT1, could influence the risk of spina bifida via either folate catabolism or acetylation of exogenous agents.	Folic Acid	117-123	N-acetyltransferase 1	Homo sapiens	59-63
16680433-10	2006	These associations may be attributable to a decrease in either folate catabolism or the conversion of exogenous agents to teratogenic derivatives in women and/or developing embryos with a NAT1 genotype that includes a loss of function allele relative to those who do not.	Folic Acid	63-69	N-acetyltransferase 1	Homo sapiens	188-192
16453285-1	2006	Folate receptor alpha (FRalpha) is a membrane-bound protein with high affinity for binding and transporting physiologic levels of folate into cells.	Folic Acid	130-136	folate receptor alpha	Homo sapiens	0-21
16453285-1	2006	Folate receptor alpha (FRalpha) is a membrane-bound protein with high affinity for binding and transporting physiologic levels of folate into cells.	Folic Acid	130-136	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	23-30
16453285-4	2006	It has been suggested that FRalpha might confer a growth advantage to the tumor by modulating folate uptake from serum or by generating regulatory signals.	Folic Acid	94-100	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	27-34
16453285-5	2006	Indeed, cell culture studies show that expression of the FRalpha gene, FOLR1, is regulated by extracellular folate depletion, increased homocysteine accumulation, steroid hormone concentrations, interaction with specific transcription factors and cytosolic proteins, and possibly genetic mutations.	Folic Acid	108-114	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	57-64
16453285-5	2006	Indeed, cell culture studies show that expression of the FRalpha gene, FOLR1, is regulated by extracellular folate depletion, increased homocysteine accumulation, steroid hormone concentrations, interaction with specific transcription factors and cytosolic proteins, and possibly genetic mutations.	Folic Acid	108-114	folate receptor alpha	Homo sapiens	71-76
16712799-10	2006	FDH-resistant cells have strongly up-regulated dihydrofolate reductase (DHFR) that is proposed to be a mechanism for the alteration of folate pools and a key component of the acquired resistance.	Folic Acid	54-60	dihydrofolate reductase	Homo sapiens	72-76
16790925-2	2006	The amino-acid sequence and molecular architecture of R67 DHFR and its inhibitory properties toward folate analogues are different from those of chromosomal DHFR.	Folic Acid	100-106	dihydrofolate reductase	Homo sapiens	58-62
16697371-4	2006	Hcy itself or folate and vitamin B12 deficiency can cause disturbed methylation and/or redox potentials, thus promoting calcium influx, amyloid and tau protein accumulation, apoptosis, and neuronal death.	Folic Acid	14-20	microtubule associated protein tau	Homo sapiens	148-151
16611376-0	2006	In vitro folate deficiency induces apoptosis by a p53, Fas (Apo-1, CD95) independent, bcl-2 related mechanism in phytohaemagglutinin-stimulated human peripheral blood lymphocytes.	Folic Acid	9-15	Fas cell surface death receptor	Homo sapiens	60-65
16611376-0	2006	In vitro folate deficiency induces apoptosis by a p53, Fas (Apo-1, CD95) independent, bcl-2 related mechanism in phytohaemagglutinin-stimulated human peripheral blood lymphocytes.	Folic Acid	9-15	Fas cell surface death receptor	Homo sapiens	67-71
16536979-1	2006	BACKGROUND &amp; OBJECTIVE: Serine hydroxymethyltransferase (SHMT), a key enzyme in the folate metabolism, affects gene methylation and DNA synthesis through providing one-carbon units for purine, thymidylate, and methionine.	Folic Acid	88-94	serine hydroxymethyltransferase 1	Homo sapiens	28-59
16536979-1	2006	BACKGROUND &amp; OBJECTIVE: Serine hydroxymethyltransferase (SHMT), a key enzyme in the folate metabolism, affects gene methylation and DNA synthesis through providing one-carbon units for purine, thymidylate, and methionine.	Folic Acid	88-94	serine hydroxymethyltransferase 1	Homo sapiens	61-65
16505119-6	2006	Folate pools were contracted in PT1 cells by 32% or 60%, as measured by radiolabeling intracellular folates or by an enzyme binding assay, respectively.	Folic Acid	0-6	zinc finger protein 77	Homo sapiens	32-35
16505119-6	2006	Folate pools were contracted in PT1 cells by 32% or 60%, as measured by radiolabeling intracellular folates or by an enzyme binding assay, respectively.	Folic Acid	100-107	zinc finger protein 77	Homo sapiens	32-35
16111879-0	2006	Decreased TGF-beta1 and IGF-1 protein expression in rat embryo skull bone in folic acid-restricted diet.	Folic Acid	77-87	insulin-like growth factor 1	Rattus norvegicus	24-29
35439435-4	2022	An initial antibiotic screen in Firmicutes revealed that c-di-AMP production was largely driven by antifolate antibiotics targeting dihydrofolate reductase (DHFR), which promotes folate regeneration required for thymidine biosynthesis.	Folic Acid	179-185	Dihydrofolate reductase	Staphylococcus aureus	132-155
16111879-11	2006	The folic acid-restricted diet (5 microg) resulted in decreased serum TGF-beta1 and IGF-1 levels.	Folic Acid	4-14	insulin-like growth factor 1	Rattus norvegicus	84-89
35439435-4	2022	An initial antibiotic screen in Firmicutes revealed that c-di-AMP production was largely driven by antifolate antibiotics targeting dihydrofolate reductase (DHFR), which promotes folate regeneration required for thymidine biosynthesis.	Folic Acid	179-185	Dihydrofolate reductase	Staphylococcus aureus	157-161
16111879-12	2006	Furthermore, protein expression of TGF-beta1 and IGF-1 in E18-19 rat skull bones was also significantly lower in the folic acid-restricted diet than in the normal diet.	Folic Acid	117-127	insulin-like growth factor 1	Rattus norvegicus	49-54
16256389-1	2006	Folate binding protein 1 (Folr1) knockout mice with low maternal folate concentrations have been shown to be excellent animal models for human folate-responsive neural tube defects (NTDs).	Folic Acid	65-71	folate receptor 1 (adult)	Mus musculus	0-24
16256389-1	2006	Folate binding protein 1 (Folr1) knockout mice with low maternal folate concentrations have been shown to be excellent animal models for human folate-responsive neural tube defects (NTDs).	Folic Acid	65-71	folate receptor 1 (adult)	Mus musculus	26-31
16256389-1	2006	Folate binding protein 1 (Folr1) knockout mice with low maternal folate concentrations have been shown to be excellent animal models for human folate-responsive neural tube defects (NTDs).	Folic Acid	143-149	folate receptor 1 (adult)	Mus musculus	0-24
35045271-0	2022	Neonatal Hyperoxia Activates ATF4 to Stimulate Folate Metabolism and AT2 Cell Proliferation.	Folic Acid	47-53	activating transcription factor 4	Homo sapiens	29-33
16256389-1	2006	Folate binding protein 1 (Folr1) knockout mice with low maternal folate concentrations have been shown to be excellent animal models for human folate-responsive neural tube defects (NTDs).	Folic Acid	143-149	folate receptor 1 (adult)	Mus musculus	26-31
16256389-2	2006	Previous studies using the Folr1 knockout mice revealed that maternal folate supplementation up-regulates the expression of the PCMT1 gene in Folr1 nullizygous neural tube tissue during neural tube closure.	Folic Acid	70-76	folate receptor 1 (adult)	Mus musculus	27-32
16256389-2	2006	Previous studies using the Folr1 knockout mice revealed that maternal folate supplementation up-regulates the expression of the PCMT1 gene in Folr1 nullizygous neural tube tissue during neural tube closure.	Folic Acid	70-76	folate receptor 1 (adult)	Mus musculus	142-147
16162503-8	2005	Insertional inactivation of At2g32040 significantly raised the total folate content of chloroplasts and lowered the proportion of 5-methyltetrahydrofolate but did not discernibly affect growth.	Folic Acid	69-75	Major facilitator superfamily protein	Arabidopsis thaliana	28-37
35346016-6	2022	Specifically, the most studied polymorphism is 677T-C in exon 5 of the 5,10- methylenetetrahydrofolate reductase (MTHFR) gene, which plays an important role in folate"s metabolism.	Folic Acid	160-166	methylenetetrahydrofolate reductase	Homo sapiens	77-112
35346016-6	2022	Specifically, the most studied polymorphism is 677T-C in exon 5 of the 5,10- methylenetetrahydrofolate reductase (MTHFR) gene, which plays an important role in folate"s metabolism.	Folic Acid	160-166	methylenetetrahydrofolate reductase	Homo sapiens	114-119
15930032-2	2005	We hypothesized that the polymorphisms of thymidylate synthase (TYMS) gene involved in folate metabolism are associated with GC risk.	Folic Acid	87-93	thymidylate synthetase	Homo sapiens	42-62
34990050-5	2022	We then found that YTHDF1 was also up-regulated in fibrotic mouse kidneys induced by unilateral ureteral obstruction (UUO), high-dose folic acid administration, or the unilateral ischemia-reperfusion injury, further supporting a causal role of YTHDF1 during renal fibrosis.	Folic Acid	134-144	YTH N6-methyladenosine RNA binding protein 1	Mus musculus	19-25
15930032-2	2005	We hypothesized that the polymorphisms of thymidylate synthase (TYMS) gene involved in folate metabolism are associated with GC risk.	Folic Acid	87-93	thymidylate synthetase	Homo sapiens	64-68
35228749-1	2022	The folate metabolism enzyme MTHFD2 (methylenetetrahydrofolate dehydrogenase/cyclohydrolase) is consistently overexpressed in cancer but its roles are not fully characterized, and current candidate inhibitors have limited potency for clinical development.	Folic Acid	4-10	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	Homo sapiens	29-35
16096989-1	2005	Stereoselectivity of the human reduced folate carrier (RFC1) was examined in Caco-2 cells using methotrexate (l-amethopterin or l-MTX) and its antipode (d-amethopterin or d-MTX) as model substrates.	Folic Acid	39-45	metaxin 1	Homo sapiens	130-133
16096989-1	2005	Stereoselectivity of the human reduced folate carrier (RFC1) was examined in Caco-2 cells using methotrexate (l-amethopterin or l-MTX) and its antipode (d-amethopterin or d-MTX) as model substrates.	Folic Acid	39-45	metaxin 1	Homo sapiens	173-176
35166995-3	2022	METHODS: For this purpose, we used folic acid (FA)-conjugated SPION-carboxymethyl dextran (CMD) chitosan (C) nanoparticles (NPs) to deliver anti-beta-catenin siRNA and IL-15 to cancer cells.	Folic Acid	35-45	catenin (cadherin associated protein), beta 1	Mus musculus	145-157
15777559-5	2005	After patients with HHcy underwent low-dose folic acid treatment (0.8 mg/d) for 6 months, plasma Hcy levels were decreased and the hyper-responsiveness of MCP-1 and IL-8 secreted by isolated monocytes was significantly reversed.	Folic Acid	44-54	C-C motif chemokine ligand 2	Homo sapiens	155-160
35166995-3	2022	METHODS: For this purpose, we used folic acid (FA)-conjugated SPION-carboxymethyl dextran (CMD) chitosan (C) nanoparticles (NPs) to deliver anti-beta-catenin siRNA and IL-15 to cancer cells.	Folic Acid	35-45	interleukin 15	Mus musculus	168-173
15755837-2	2005	Dihydrofolate reductase (DHFR) is required to convert the folic acid used in supplements and for food fortification and the dihydrofolate produced by thymidylate synthase during DNA synthesis to the reduced folate forms used by the cell.	Folic Acid	58-68	dihydrofolate reductase	Homo sapiens	0-23
35099545-13	2022	Compared with participants in the second quartile of serum folate levels (7.1-12.1 ng/mL), the hazard ratios for CVD mortality were 1.43 (95% CI, 1.04-1.98) for participants in the lowest serum folate level quartile (<7.1 ng/mL) and 1.03 (95% CI, 0.74-1.44) for participants in the highest quartile (>=19.5 ng/mL).	Folic Acid	59-65	thrombopoietin	Mus musculus	86-88
15755837-2	2005	Dihydrofolate reductase (DHFR) is required to convert the folic acid used in supplements and for food fortification and the dihydrofolate produced by thymidylate synthase during DNA synthesis to the reduced folate forms used by the cell.	Folic Acid	58-68	dihydrofolate reductase	Homo sapiens	25-29
2671982-6	1989	Methionine synthase in P. falciparum may play a role in the supply of methionine and in folate salvage using exogenous 5-CH3-H4PteGlu for tetrahydrofolate metabolism.	Folic Acid	88-94	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	0-19
15755837-2	2005	Dihydrofolate reductase (DHFR) is required to convert the folic acid used in supplements and for food fortification and the dihydrofolate produced by thymidylate synthase during DNA synthesis to the reduced folate forms used by the cell.	Folic Acid	7-13	dihydrofolate reductase	Homo sapiens	25-29
15755837-2	2005	Dihydrofolate reductase (DHFR) is required to convert the folic acid used in supplements and for food fortification and the dihydrofolate produced by thymidylate synthase during DNA synthesis to the reduced folate forms used by the cell.	Folic Acid	7-13	thymidylate synthetase	Homo sapiens	150-170
15703271-8	2005	Folbp1 is heavily expressed in choroid plexus, yolk sac, and placenta, supporting a role of folbp1 in folate transport in other tissues.	Folic Acid	102-108	folate receptor 1 (adult)	Mus musculus	92-98
15703271-9	2005	The greatest significance of folbp1 for renal folate uptake was observed at conditions of low folate intake, providing a possible explanation for the ability of folate supplementation to prevent developmental defects associated with folbp1 inactivation.	Folic Acid	46-52	folate receptor 1 (adult)	Mus musculus	29-35
15703271-9	2005	The greatest significance of folbp1 for renal folate uptake was observed at conditions of low folate intake, providing a possible explanation for the ability of folate supplementation to prevent developmental defects associated with folbp1 inactivation.	Folic Acid	46-52	folate receptor 1 (adult)	Mus musculus	233-239
15703271-9	2005	The greatest significance of folbp1 for renal folate uptake was observed at conditions of low folate intake, providing a possible explanation for the ability of folate supplementation to prevent developmental defects associated with folbp1 inactivation.	Folic Acid	94-100	folate receptor 1 (adult)	Mus musculus	29-35
15703271-9	2005	The greatest significance of folbp1 for renal folate uptake was observed at conditions of low folate intake, providing a possible explanation for the ability of folate supplementation to prevent developmental defects associated with folbp1 inactivation.	Folic Acid	94-100	folate receptor 1 (adult)	Mus musculus	29-35
15531579-10	2005	Furthermore, this study establishes that SHMT1 is a zinc-inducible gene, which provides the first mechanism for the regulation of folate-mediated one-carbon metabolism by zinc.	Folic Acid	130-136	serine hydroxymethyltransferase 1	Homo sapiens	41-46
15816513-4	2005	MATERIALS AND METHODS: Two types of conjugate were evaluated: (i) folate conjugated to osteosarcoma antigen directed murine monoclonal antibodies TP-1 and TP-3 or (ii) folate conjugated to non-specific polyclonal human IgG (HIg6).	Folic Acid	66-72	transition protein 1	Homo sapiens	146-150
15816513-7	2005	Folate conjugates of TP-1 and TP-3 had a selective binding in vitro to antigen-expressing tumor cells and also to cells expressing FR only, thus the folate antibody constructs possessed dual affinity binding.	Folic Acid	0-6	transition protein 1	Homo sapiens	21-34
15523664-2	2004	We investigated whether polymorphic variants of fetal acetyl-N-transferase 1 (NAT1), an enzyme involved in the catabolism of folates, differentially interacted with maternal multivitamin use during early pregnancy to alter the risk of delivering an infant with an orofacial cleft malformation.	Folic Acid	125-132	N-acetyltransferase 1	Homo sapiens	78-82
15198953-8	2004	The associations of DLCL and FL with TYMS 1494del6 and MTHFR 677TT genotypes, respectively, suggest that folate metabolism may play an important role in the pathogenesis of specific subtypes of NHL.	Folic Acid	105-111	thymidylate synthetase	Homo sapiens	37-41
15454255-8	2004	In vitro, MTX, folic and folinic acids inhibited the activity of glyoxalase I.	Folic Acid	15-20	glyoxalase I	Homo sapiens	65-77
15305303-0	2004	Embryonic development of folate binding protein-1 (Folbp1) knockout mice: Effects of the chemical form, dose, and timing of maternal folate supplementation.	Folic Acid	25-31	folate receptor 1 (adult)	Mus musculus	51-57
15305303-4	2004	We also examined the critical period during gestation when folate supplementation is most beneficial to the developing Folbp1(-/-) embryos.	Folic Acid	59-65	folate receptor 1 (adult)	Mus musculus	119-125
15142039-0	2004	Quantitative description of the interaction between folate and the folate-binding protein from cow"s milk.	Folic Acid	52-58	folate receptor alpha	Bos taurus	67-89
15142039-1	2004	A detailed study has been carried out on the dependence of folate binding on the concentration of FBP (folate-binding protein) at pH 5.0, conditions selected to prevent complications arising from the pre-existing self-association of the acceptor.	Folic Acid	59-65	folate receptor alpha	Bos taurus	98-101
15142039-1	2004	A detailed study has been carried out on the dependence of folate binding on the concentration of FBP (folate-binding protein) at pH 5.0, conditions selected to prevent complications arising from the pre-existing self-association of the acceptor.	Folic Acid	59-65	folate receptor alpha	Bos taurus	103-125
15142039-2	2004	In contrast with the mandatory requirement that reversible interaction of ligand with a single acceptor site should exhibit a unique, rectangular hyperbolic binding curve, results obtained by ultrafiltration for the FBP-folate system required description in terms of (i) a sigmoidal relationship between concentrations of bound and free folate and (ii) an inverse dependence of affinity on FBP concentration.	Folic Acid	220-226	folate receptor alpha	Bos taurus	216-219
15142039-3	2004	These findings have been attributed to the difficulties in determining the free ligand concentration in the FBP-folate mixtures for which reaction is essentially stoichiometric.	Folic Acid	112-118	folate receptor alpha	Bos taurus	108-111
15142039-4	2004	This explanation also accounts for the similar published behaviour of the FBP-folate system at neutral pH, which had been attributed erroneously to acceptor self-association, a phenomenon incompatible with the experimental findings because of its prediction of a greater affinity for folate with increasing FBP concentration.	Folic Acid	78-84	folate receptor alpha	Bos taurus	74-77
15142039-4	2004	This explanation also accounts for the similar published behaviour of the FBP-folate system at neutral pH, which had been attributed erroneously to acceptor self-association, a phenomenon incompatible with the experimental findings because of its prediction of a greater affinity for folate with increasing FBP concentration.	Folic Acid	78-84	folate receptor alpha	Bos taurus	307-310
15142039-4	2004	This explanation also accounts for the similar published behaviour of the FBP-folate system at neutral pH, which had been attributed erroneously to acceptor self-association, a phenomenon incompatible with the experimental findings because of its prediction of a greater affinity for folate with increasing FBP concentration.	Folic Acid	284-290	folate receptor alpha	Bos taurus	74-77
15272307-1	2004	Mammalian formiminotransferase cyclodeaminase (FTCD), a 0.5 million Dalton homo-octameric enzyme, plays important roles in coupling histidine catabolism with folate metabolism and integrating the Golgi complex with the vimentin intermediate filament cytoskeleton.	Folic Acid	158-164	vimentin	Homo sapiens	219-227
15203205-2	2004	Expansion of CGG/CCG repeats has been shown to be the molecular basis of all five folate-sensitive fragile sites characterized molecularly so far, i.e., FRAXA, FRAXE, FRAXF, FRA11B, and FRA16A.	Folic Acid	82-88	fragile site, folic acid type, rare, fra(X)(q28) E	Homo sapiens	160-165
15203205-2	2004	Expansion of CGG/CCG repeats has been shown to be the molecular basis of all five folate-sensitive fragile sites characterized molecularly so far, i.e., FRAXA, FRAXE, FRAXF, FRA11B, and FRA16A.	Folic Acid	82-88	Cbl proto-oncogene	Homo sapiens	174-180
15203205-2	2004	Expansion of CGG/CCG repeats has been shown to be the molecular basis of all five folate-sensitive fragile sites characterized molecularly so far, i.e., FRAXA, FRAXE, FRAXF, FRA11B, and FRA16A.	Folic Acid	82-88	fragile site, folic acid type, rare, fra(16)(p13.11)	Homo sapiens	186-192
15625773-3	2004	Clinical examination and laboratory findings revealed a PGA syndrome due to the presence of hypergonadotropic hypogonadism, insufficient growth hormone response and thyroid autoimmunity.	Folic Acid	56-59	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	92-122
15122597-9	2004	Although compound homozygous variants at cSHMT and MTHFD1 loci had the lowest plasma folate levels compared to other compound genotypes, no significant gene-gene interactions were observed.	Folic Acid	85-91	serine hydroxymethyltransferase 1	Homo sapiens	41-46
15339053-4	2004	Another promising agent is pemetrexed (Alimta), a folate-based inhibitor of thymidylate synthase.	Folic Acid	50-56	thymidylate synthetase	Homo sapiens	76-96
3116769-1	1987	After administration into rats of folic acid at a dose of 25 mg/kg within 14 days activities of NADPH-cytochrome P-450 and NADH-cytochrome b5 reductases, content of cytochromes P-450 and b5 as well as the rates of NADPH and NADH oxidation were increased in liver microsomes.	Folic Acid	34-44	cytochrome b5 type A	Rattus norvegicus	128-141
15170323-10	2004	These results clearly indicate that interaction of Glu75 with folate is required for folate-dependent reactions catalyzed by SHMT.	Folic Acid	62-68	serine hydroxymethyltransferase 1	Homo sapiens	125-129
3565582-3	1987	To assess the possible involvement of this protein in renal conservation of folate we determined the urinary clearance, in rats, of three forms of folates with sharply different affinities for FBP.	Folic Acid	147-154	far upstream element binding protein 1	Rattus norvegicus	193-196
15170323-10	2004	These results clearly indicate that interaction of Glu75 with folate is required for folate-dependent reactions catalyzed by SHMT.	Folic Acid	85-91	serine hydroxymethyltransferase 1	Homo sapiens	125-129
3928628-2	1985	In an effort to establish the site by which H4folate is attached to FdUMP, the ternary complex was subjected to reagents that cleave the C-9, N-10 bond of folate derivatives.	Folic Acid	46-52	complement C9	Homo sapiens	137-140
15147873-3	2004	RFC1- as well as MTX-1-mediated uptake of a marker substrate into suitable human and rat cell lines increased with proton concentration, was sodium-dependent at neutral pH, and inhibited by folate at acidic pH.	Folic Acid	190-196	metaxin 1	Homo sapiens	17-22
3873989-12	1985	The activities of folate and antifolate substrates also have been determined with rat liver FPGS.	Folic Acid	18-24	folylpolyglutamate synthase	Rattus norvegicus	92-96
6324026-1	1984	The actions of the neurotoxic amino acids folate and kainate have been compared on ortho-and antidromic responses evoked in CA1, CA3 and the dentate gyrus of slices of rat hippocampus maintained in vitro.	Folic Acid	42-48	carbonic anhydrase 3	Rattus norvegicus	129-132
6324026-3	1984	In the CA3 region kainate and folate had broadly similar actions to enhance the probability of cell firing to synaptic excitation, and also caused epileptiform discharges to occur spontaneously or in response to electrical stimulation.	Folic Acid	30-36	carbonic anhydrase 3	Rattus norvegicus	7-10
15122759-4	2004	Ethanol feeding or folate deficiency, separately or in combination, decreased transcript levels of methylenetetrahydrofolate reductase (MTHFR), methionine adenosyltransferase (MAT1A), glycine-N-methyltransferase (GNMT) and S-adenosylhomocysteine hydrolase (SAHH).	Folic Acid	19-25	adenosylhomocysteinase	Homo sapiens	223-255
6324026-5	1984	Following folate superfusion the commissural-evoked response in CA3 showed large and variable shifts of the latency which were dependent on the stimulus intensity and its timing after a spontaneous population discharge.	Folic Acid	10-16	carbonic anhydrase 3	Rattus norvegicus	64-67
15122759-4	2004	Ethanol feeding or folate deficiency, separately or in combination, decreased transcript levels of methylenetetrahydrofolate reductase (MTHFR), methionine adenosyltransferase (MAT1A), glycine-N-methyltransferase (GNMT) and S-adenosylhomocysteine hydrolase (SAHH).	Folic Acid	19-25	adenosylhomocysteinase	Homo sapiens	257-261
15019156-0	2004	Folic acid reduces nuclear translocation of beta-catenin in rectal mucosal crypts of patients with colorectal adenomas.	Folic Acid	0-10	catenin beta 1	Homo sapiens	44-56
15019156-2	2004	We examined the effect of one year supplemental folic acid (5 mg/day) on the rectal mucosal expression of beta-catenin and pGSK3beta, known to be affected by EGF-R, in patients with colorectal adenomas.	Folic Acid	48-58	catenin beta 1	Homo sapiens	106-118
15019156-3	2004	Folic acid treatment significantly reduced nuclear expression of beta-catenin (P &lt; 0.05) and cellular expression of pGSK3beta (P &lt; 0.01) when compared to placebo.	Folic Acid	0-10	catenin beta 1	Homo sapiens	65-77
28523-1	1978	The thermodynamic parameters, deltaG, deltaH, and deltaS characterizing the tight binding of methotrexate, folates, and pyridine nucleotides to chicken liver dihydrofolate reductase (5,6,7,8-tetrahydrofolate: NADP+ oxidoreductase, EC 1.5.1.3) have been determined from calorimetric and fluorescence measurements.	Folic Acid	107-114	dihydrofolate reductase	Gallus gallus	158-181
15019156-4	2004	Folic acid may exert its chemopreventive effect, at least in part, through inhibition of nuclear translocation of beta-catenin.	Folic Acid	0-10	catenin beta 1	Homo sapiens	114-126
15142281-3	2004	In addition to its xenobiotic-metabolising capacity, human arylamine N-acetyltransferase type-1 (NAT1) acetylates the folate catabolite para-aminobenzoylglutamate and is implicated in folate metabolism.	Folic Acid	118-124	N-acetyltransferase 1	Homo sapiens	97-101
147465-3	1978	Likewise, the intracellular amount of 5-fluoro-2"-deoxyuridylate covalently bound to thymidylate synthase in L1210 cells treated with 5-fluoro-2"-deoxyuridine is greatly diminished when cells are depleted of folate cofactors.	Folic Acid	208-214	thymidylate synthase	Mus musculus	85-105
15142281-3	2004	In addition to its xenobiotic-metabolising capacity, human arylamine N-acetyltransferase type-1 (NAT1) acetylates the folate catabolite para-aminobenzoylglutamate and is implicated in folate metabolism.	Folic Acid	184-190	N-acetyltransferase 1	Homo sapiens	97-101
22555-3	1978	To further explore the mechanism of sulfasalazine action, the interaction of the drug with the folate recognition site was tested with three enzymes: dihydrofolate reductase, methylenetetrahydrofolate reductase, and serine transhydroxymethylase, each catalyzing a reaction involving a different folate derivative.	Folic Acid	95-101	dihydrofolate reductase	Gallus gallus	150-173
14735580-10	2004	About half of dietary folates and all of folic acid supplements must be reduced by DHFR to be available for mother and fetus.	Folic Acid	22-29	dihydrofolate reductase	Homo sapiens	83-87
4253882-0	1970	[Behavior of deoxyribonuclease I and II during folic acid hyperplasia of the kidney].	Folic Acid	47-57	deoxyribonuclease 1	Homo sapiens	13-39
14735580-10	2004	About half of dietary folates and all of folic acid supplements must be reduced by DHFR to be available for mother and fetus.	Folic Acid	41-51	dihydrofolate reductase	Homo sapiens	83-87
32241207-0	2021	The effect of folic acid deficiency on Mest/Peg1 in neural tube defects.	Folic Acid	14-24	mesoderm specific transcript	Homo sapiens	39-43
14717591-4	2004	To understand the role of side chain dynamics in ligand binding and loop conformation, methyl deuterium relaxation rates of Escherichia coli DHFR in binary folate and ternary folate:NADP+ complexes have been measured, together with chi(1) rotamer populations for threonine, isoleucine, and valine residues, determined from measurements of 3J(CgammaCO) and 3J(CgammaN) coupling constants.	Folic Acid	156-162	Dihydrofolate reductase	Escherichia coli	141-145
32241207-0	2021	The effect of folic acid deficiency on Mest/Peg1 in neural tube defects.	Folic Acid	14-24	mesoderm specific transcript	Homo sapiens	44-48
32241207-4	2021	In the present study, we found firstly that in human folic acid-insufficient NTDs, the methylation level of imprinted gene Mest/Peg1 was decreased.	Folic Acid	53-63	mesoderm specific transcript	Homo sapiens	123-127
32241207-4	2021	In the present study, we found firstly that in human folic acid-insufficient NTDs, the methylation level of imprinted gene Mest/Peg1 was decreased.	Folic Acid	53-63	mesoderm specific transcript	Homo sapiens	128-132
32241207-5	2021	By using a folic acid-deficient cell model, we demonstrated that Mest/Peg1 methylation was descended.	Folic Acid	11-21	mesoderm specific transcript	Homo sapiens	65-69
32241207-5	2021	By using a folic acid-deficient cell model, we demonstrated that Mest/Peg1 methylation was descended.	Folic Acid	11-21	mesoderm specific transcript	Homo sapiens	70-74
32241207-6	2021	Meanwhile, the mRNA level of Mest/Peg1 was up-regulated via hypomethylation modification under low folic acid conditions.	Folic Acid	99-109	mesoderm specific transcript	Homo sapiens	29-33
14717591-4	2004	To understand the role of side chain dynamics in ligand binding and loop conformation, methyl deuterium relaxation rates of Escherichia coli DHFR in binary folate and ternary folate:NADP+ complexes have been measured, together with chi(1) rotamer populations for threonine, isoleucine, and valine residues, determined from measurements of 3J(CgammaCO) and 3J(CgammaN) coupling constants.	Folic Acid	175-181	Dihydrofolate reductase	Escherichia coli	141-145
14690438-10	2003	Binding of the folate analogue methotrexate favors a stable three-dimensional structure of the dihydrofolate reductase domain.	Folic Acid	15-21	dihydrofolate reductase	Homo sapiens	95-118
12946272-1	2003	Human N -acetyltransferase Type I (NAT1) catalyses the acetylation of many aromatic amine and hydrazine compounds and it has been implicated in the catabolism of folic acid.	Folic Acid	162-172	N-acetyltransferase 1	Homo sapiens	35-39
14705776-11	2003	This analysis affords a new analytical assay for the dihydrofolate reductase-catalyzed reaction and several dehydrogenases involved in folic acid metabolism.	Folic Acid	135-145	dihydrofolate reductase	Homo sapiens	53-76
14656016-0	2003	DACH-LIGA homocystein (german, austrian and swiss homocysteine society): consensus paper on the rational clinical use of homocysteine, folic acid and B-vitamins in cardiovascular and thrombotic diseases: guidelines and recommendations.	Folic Acid	135-145	dachshund family transcription factor 1	Homo sapiens	0-21
14578131-6	2003	In addition, an increased risk of colorectal adenoma (OR, 17.1; 95% CI, 2.1-137) was observed for those with the ADH3(2-2) genotype and high alcohol-low folate intake compared with those with low alcohol-high folate intake and the ADH3(1-1) genotype (P for interaction = 0.006).	Folic Acid	209-215	alcohol dehydrogenase 1C (class I), gamma polypeptide	Homo sapiens	113-117
14578131-8	2003	The findings that alcohol interacts with a folate-related gene (MTHFR) and that the interaction between alcohol and ADH3 is stronger among those with low folate intake support the hypothesis that the carcinogenic influence of alcohol in the large bowel is mediated through folate status.	Folic Acid	154-160	alcohol dehydrogenase 1C (class I), gamma polypeptide	Homo sapiens	116-120
14500880-3	2003	The backbone chemical shifts have been compared with those of the binary complex of DHFR with the substrate analog folate and the binary complex with NADPH (the holoenzyme).	Folic Acid	115-121	Dihydrofolate reductase	Escherichia coli	84-88
12963755-7	2003	CSF investigations in three patients with classic AGS also showed increased pterins and partially lowered folate levels.	Folic Acid	106-112	colony stimulating factor 2	Homo sapiens	0-3
12963755-9	2003	Long-term substitution with folinic acid (2-4 mg/kg/day) resulted in substantial clinical recovery with normalization of CSF folates and pterins in one patient and clinical improvement in another.	Folic Acid	125-132	colony stimulating factor 2	Homo sapiens	121-124
12909365-1	2003	Human gamma-glutamyl hydrolase (hGH) plays an important role in the metabolism of folic acid and the pharmacology of antifolates such as methotrexate.	Folic Acid	82-92	gamma-glutamyl hydrolase	Homo sapiens	6-30
12697024-13	2003	Phosphorylation of GNMT would thus seem to play no role in regulation of the intracellular AdoMet/AdoHcy ratio, but could be involved in other GNMT functions, such as the binding of folates or aromatic hydrocarbons.	Folic Acid	182-189	glycine N-methyltransferase	Rattus norvegicus	19-23
12839949-2	2003	The nonpolyglutamatable folate-based thymidylate synthase (TS) inhibitor, CB300638 (TS K(i) = 0.24 nM) displayed an IC(50) of 0.0028 microM for the inhibition of the growth of human A431-FBP cells transfected with the alpha-FR.	Folic Acid	24-30	thymidylate synthetase	Homo sapiens	37-57
12839949-2	2003	The nonpolyglutamatable folate-based thymidylate synthase (TS) inhibitor, CB300638 (TS K(i) = 0.24 nM) displayed an IC(50) of 0.0028 microM for the inhibition of the growth of human A431-FBP cells transfected with the alpha-FR.	Folic Acid	24-30	folate receptor beta	Homo sapiens	187-190
12831362-4	2003	An apparent post-transcriptional modification prevents FR-beta in normal haematopoietic cells from binding folate, in contrast to AML cells.	Folic Acid	107-113	folate receptor beta	Homo sapiens	55-62
12757380-0	2003	Folate-targeted PEG as a potential carrier for carboplatin analogs.	Folic Acid	0-6	progestagen associated endometrial protein	Homo sapiens	16-19
12583828-4	2003	Methotrexate inhibits dihydrofolate reductase, which leads to accumulation of polyglutamated folates, causing further inhibition of thymidylate synthase and glycinamide ribonucleotide formyltransferase.	Folic Acid	93-100	dihydrofolate reductase	Homo sapiens	22-45
12566489-2	2003	Milk folate is entirely bound by an excess of folate-binding protein (FBP), prompting speculation that FBP may affect the bioavailability of the limited folate supply.	Folic Acid	5-11	glycine N-methyltransferase	Rattus norvegicus	46-68
12566489-2	2003	Milk folate is entirely bound by an excess of folate-binding protein (FBP), prompting speculation that FBP may affect the bioavailability of the limited folate supply.	Folic Acid	5-11	glycine N-methyltransferase	Rattus norvegicus	70-73
12566489-2	2003	Milk folate is entirely bound by an excess of folate-binding protein (FBP), prompting speculation that FBP may affect the bioavailability of the limited folate supply.	Folic Acid	5-11	glycine N-methyltransferase	Rattus norvegicus	103-106
12566489-2	2003	Milk folate is entirely bound by an excess of folate-binding protein (FBP), prompting speculation that FBP may affect the bioavailability of the limited folate supply.	Folic Acid	46-52	glycine N-methyltransferase	Rattus norvegicus	70-73
12566489-2	2003	Milk folate is entirely bound by an excess of folate-binding protein (FBP), prompting speculation that FBP may affect the bioavailability of the limited folate supply.	Folic Acid	46-52	glycine N-methyltransferase	Rattus norvegicus	103-106
12566489-3	2003	Previous research has shown that FBP-bound folic acid is more gradually absorbed, thereby reducing the peak plasma folate concentration and preventing loss into the urine.	Folic Acid	43-53	glycine N-methyltransferase	Rattus norvegicus	33-36
12566489-3	2003	Previous research has shown that FBP-bound folic acid is more gradually absorbed, thereby reducing the peak plasma folate concentration and preventing loss into the urine.	Folic Acid	115-121	glycine N-methyltransferase	Rattus norvegicus	33-36
12566489-5	2003	We studied the effect of FBP on folate nutrition of rats in both single-dose and 4-wk feeding experiments.	Folic Acid	32-38	glycine N-methyltransferase	Rattus norvegicus	25-28
12566489-7	2003	FBP increased bioavailability of dietary folate when it was consumed with other whey proteins or with soluble casein.	Folic Acid	41-47	glycine N-methyltransferase	Rattus norvegicus	0-3
12566489-10	2003	They suggest that the addition of FBP-rich foods to folate-rich foods could enhance the bioavailability of natural folates, but that the outcome of such a combination would depend on interactions with other components of the diet.	Folic Acid	115-122	glycine N-methyltransferase	Rattus norvegicus	34-37
12538352-0	2003	The effect of dietary folate on genomic and p53-specific DNA methylation in rat colon.	Folic Acid	22-28	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	44-47
32241207-6	2021	Meanwhile, the mRNA level of Mest/Peg1 was up-regulated via hypomethylation modification under low folic acid conditions.	Folic Acid	99-109	mesoderm specific transcript	Homo sapiens	34-38
32241207-7	2021	Consistent with the results in cell models, Mest/Peg1 expression was elevated through hypomethylation regulation in folate-deficient animal models.	Folic Acid	116-122	mesoderm specific transcript	Homo sapiens	44-48
32241207-7	2021	Consistent with the results in cell models, Mest/Peg1 expression was elevated through hypomethylation regulation in folate-deficient animal models.	Folic Acid	116-122	mesoderm specific transcript	Homo sapiens	49-53
12538352-2	2003	This study investigated the time-dependent effects of dietary folate on genomic and p53 (in the promoter region and exons 6-7) DNA methylation in rat colon, and how these changes are related to steady-state levels of p53 transcript.	Folic Acid	62-68	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	84-87
32241207-9	2021	Similar results with Lrp6 down-regulation of fetal brain were verified in animal models under folic acid-deficient condition.	Folic Acid	94-104	LDL receptor related protein 6	Homo sapiens	21-25
32241207-10	2021	Taken together, our findings indicated folic acid increased the expression of Mest/Peg1 via hypomethylation modification, and then inhibited Lrp6 expression, which may ultimately impact on the development of nervous system through the inactivation of Wnt pathway.	Folic Acid	39-49	mesoderm specific transcript	Homo sapiens	78-82
12538352-7	2003	Dietary folate deprivation progressively decreased, whereas supplementation increased, steady-state levels of p53 transcript over 5 weeks (P &lt; 0.05).	Folic Acid	8-14	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	110-113
32241207-10	2021	Taken together, our findings indicated folic acid increased the expression of Mest/Peg1 via hypomethylation modification, and then inhibited Lrp6 expression, which may ultimately impact on the development of nervous system through the inactivation of Wnt pathway.	Folic Acid	39-49	mesoderm specific transcript	Homo sapiens	83-87
32241207-10	2021	Taken together, our findings indicated folic acid increased the expression of Mest/Peg1 via hypomethylation modification, and then inhibited Lrp6 expression, which may ultimately impact on the development of nervous system through the inactivation of Wnt pathway.	Folic Acid	39-49	LDL receptor related protein 6	Homo sapiens	141-145
12538352-8	2003	Steady-state levels of p53 mRNA correlated directly with plasma and colonic folate concentrations (P = 0.41-0.49, P &lt; 0.002) and inversely with plasma homocysteine and colonic SAH levels (r = -0.37-0.49, P &lt; 0.006), but did not significantly correlates with either genomic or p53 methylation within the promoter region and exons 6-7.	Folic Acid	76-82	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	23-26
12538352-9	2003	The data indicate that isolated folate deficiency, which significantly reduces steady-state levels of colonic p53 mRNA, is not associated with a significant degree of genomic or p53 DNA hypomethylation in rat colon.	Folic Acid	32-38	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	110-113
12728194-0	2003	Homocysteine and folate deficiency sensitize oligodendrocytes to the cell death-promoting effects of a presenilin-1 mutation and amyloid beta-peptide.	Folic Acid	17-23	presenilin 1	Mus musculus	103-115
33913025-8	2021	Furthermore, maternal folate supplementation may help to offset some of the risks of CHD in offspring due to maternal RFC1 genetic variants.	Folic Acid	22-28	replication factor C subunit 1	Homo sapiens	118-122
33913025-10	2021	Studies have assessed the associations of folate metabolism-related genes with CHD, but genes involved in cellular transportation of folate, such as the RFC1 gene, have not garnered enough attention.	Folic Acid	133-139	replication factor C subunit 1	Homo sapiens	153-157
12372420-1	2002	The aim of this work was to characterize folates modified by ONOO(-) and HOCl and to evaluate the binding capacity of folates modified by ONOO(-) to folate receptor alpha and beta.	Folic Acid	118-125	folate receptor alpha	Homo sapiens	149-170
33913025-13	2021	Folate supplementation may help to offset some risks of CHD due to RFC1 genetic variants.	Folic Acid	0-6	replication factor C subunit 1	Homo sapiens	67-71
12217808-8	2002	PML-tHCy was negatively correlated with folate in both sexes, and with vitamin B12 and age in women only.	Folic Acid	40-46	PML nuclear body scaffold	Homo sapiens	0-3
33923969-1	2021	Methylenetetrahydrofolate reductase (MTHFR) has various polymorphisms, and the effects of periconceptional folic acid supplementation for decreasing neural tube defects (NTDs) risk differ depending on the genotypes.	Folic Acid	107-117	methylenetetrahydrofolate reductase	Homo sapiens	0-35
12217808-9	2002	Folate accounted for 20% of the variance of PML-tHCy in men, while in women vitamin B12 and PLP explained 40% and 20% of variance of PML-tHCy, respectively.	Folic Acid	0-6	PML nuclear body scaffold	Homo sapiens	44-47
33923969-1	2021	Methylenetetrahydrofolate reductase (MTHFR) has various polymorphisms, and the effects of periconceptional folic acid supplementation for decreasing neural tube defects (NTDs) risk differ depending on the genotypes.	Folic Acid	107-117	methylenetetrahydrofolate reductase	Homo sapiens	37-42
12416030-0	2002	Severe folate restriction results in depletion of and alteration in the composition of the intracellular folate pool, moderate sensitization to methotrexate and trimetrexate, upregulation of endogenous DHFR activity, and overexpression of metallothionein II and folate receptor alpha that, upon folate repletion, confer drug resistance to CHL cells.	Folic Acid	7-13	metallothionein-2	Cricetulus griseus	239-257
33923969-5	2021	In 54 women (26.3% of all women) with a risk of NTDs, multivitamin supplementation containing folic acid and vitamin D for one month increased folate level (5.8 +- 0.9 to 19.2 +- 4.0 ng/mL, p < 0.0001) and decreased the homocysteine level (8.2 +- 3.1 to 5.8 +- 0.8 nmol/mL, p < 0.0001) to minimize the risk of NTDs in all women, regardless of MTHFR genotype.	Folic Acid	94-104	methylenetetrahydrofolate reductase	Homo sapiens	343-348
12221207-2	2002	In liver, methionine availability, both from the diet and via the folate-dependent one-carbon pool, modulates GNMT activity to maintain an optimal SAM:SAH ratio.	Folic Acid	66-72	glycine N-methyltransferase	Rattus norvegicus	110-114
33898503-3	2021	This study aimed to analyze the application of iron (Fe) and folic acid (FA) bovine serum albumin-nanoparticles (BSA-NPs) as anti-anemic pharmacological agents that fortify stirred functional yogurt (SFY), comparing these with a plain control and SFY fortified with Fe and FA in free forms.	Folic Acid	61-71	albumin	Rattus norvegicus	84-97
33898503-9	2021	Bovine serum albumin-nanoparticles (BSA-NPs) of iron (Fe) and folic acid (FA) can be recommended as anti-anemia supplements in different functional food applications.	Folic Acid	62-72	albumin	Rattus norvegicus	7-20
12167486-1	2002	Folate based inhibitors of thymidylate synthase (TS) might facilitate binding of 5-fluoro-2"-deoxyuridine-5"-monophosphate (FdUMP) to TS similar to the natural reduced folate 5,10-methylenetetrahydrofolate (CH(2)-H(4)-folate).	Folic Acid	0-6	thymidylate synthetase	Homo sapiens	27-47
33476699-2	2021	Intersecting these two cycles, 5,10-methylenetetrahydrofolate reductase (MTHFR) directs one-carbon units from the folate to methionine cycle, to be exclusively used for methionine and S-adenosylmethionine (AdoMet) synthesis.	Folic Acid	55-61	methylenetetrahydrofolate reductase	Homo sapiens	73-78
12167486-1	2002	Folate based inhibitors of thymidylate synthase (TS) might facilitate binding of 5-fluoro-2"-deoxyuridine-5"-monophosphate (FdUMP) to TS similar to the natural reduced folate 5,10-methylenetetrahydrofolate (CH(2)-H(4)-folate).	Folic Acid	168-174	thymidylate synthetase	Homo sapiens	27-47
12163711-2	2002	In this study, we tested whether defective intracellular folate transport, as achieved by inactivation of the murine folate-binding protein 1 (Folbp1), affects global DNA methylation in the liver and brain from gestational day (GD) 15 embryos.	Folic Acid	57-63	folate receptor 1 (adult)	Mus musculus	117-141
33528379-0	2021	Inhibition of mTOR signaling impairs rat embryo organogenesis by affecting folate availability.	Folic Acid	75-81	mechanistic target of rapamycin kinase	Rattus norvegicus	14-18
33528379-2	2021	Folate is required for embryonic ribosomal protein S6, a downstream target of mTOR Complex1, markedly reduced embryonic folate incorporation (-84%, p<0.01) and induced embryo normal embryonic development and it was recently reported that mTOR functions as a folate sensor.	Folic Acid	0-6	mechanistic target of rapamycin kinase	Rattus norvegicus	78-82
33528379-2	2021	Folate is required for embryonic ribosomal protein S6, a downstream target of mTOR Complex1, markedly reduced embryonic folate incorporation (-84%, p<0.01) and induced embryo normal embryonic development and it was recently reported that mTOR functions as a folate sensor.	Folic Acid	0-6	mechanistic target of rapamycin kinase	Rattus norvegicus	238-242
33528379-2	2021	Folate is required for embryonic ribosomal protein S6, a downstream target of mTOR Complex1, markedly reduced embryonic folate incorporation (-84%, p<0.01) and induced embryo normal embryonic development and it was recently reported that mTOR functions as a folate sensor.	Folic Acid	120-126	mechanistic target of rapamycin kinase	Rattus norvegicus	78-82
33528379-2	2021	Folate is required for embryonic ribosomal protein S6, a downstream target of mTOR Complex1, markedly reduced embryonic folate incorporation (-84%, p<0.01) and induced embryo normal embryonic development and it was recently reported that mTOR functions as a folate sensor.	Folic Acid	258-264	mechanistic target of rapamycin kinase	Rattus norvegicus	78-82
12163711-2	2002	In this study, we tested whether defective intracellular folate transport, as achieved by inactivation of the murine folate-binding protein 1 (Folbp1), affects global DNA methylation in the liver and brain from gestational day (GD) 15 embryos.	Folic Acid	57-63	folate receptor 1 (adult)	Mus musculus	143-149
33528379-3	2021	In this work we tested the hypothesis that mTOR functions as a folate sensor in the embryo and its inhibition results in embryonic developmental delay affecting neural tube closure and that these effects can be rescued by folate supplementation.	Folic Acid	63-69	mechanistic target of rapamycin kinase	Rattus norvegicus	43-47
33528379-3	2021	In this work we tested the hypothesis that mTOR functions as a folate sensor in the embryo and its inhibition results in embryonic developmental delay affecting neural tube closure and that these effects can be rescued by folate supplementation.	Folic Acid	222-228	mechanistic target of rapamycin kinase	Rattus norvegicus	43-47
33528379-7	2021	In conclusion, mTOR inhibition during organogenesis in the rat resulted in decreased folate levels in the embryo, increased embryo resorption rate and impaired embryo development.	Folic Acid	85-91	mechanistic target of rapamycin kinase	Rattus norvegicus	15-19
12163711-7	2002	Our hypothesis was that due to defective folate transport in Folbp1(-/-) embryos and fetuses, DNA would be hypomethylated, thereby altering the temporal expression of critical genes necessary for normal embryonic development.	Folic Acid	41-47	folate receptor 1 (adult)	Mus musculus	61-67
33528379-8	2021	These data suggest that mTOR signaling influences embryo folate availability, possibly by regulating transfer of folate across the maternal-embryonic interface.	Folic Acid	57-63	mechanistic target of rapamycin kinase	Rattus norvegicus	24-28
33528379-8	2021	These data suggest that mTOR signaling influences embryo folate availability, possibly by regulating transfer of folate across the maternal-embryonic interface.	Folic Acid	113-119	mechanistic target of rapamycin kinase	Rattus norvegicus	24-28
12186668-0	2002	A review of the MAFF Optimal Nutrition Status research programme: folate, iron and copper.	Folic Acid	66-72	MAF bZIP transcription factor F	Homo sapiens	16-20
33782411-0	2021	The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation.	Folic Acid	4-10	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	Homo sapiens	24-30
33782411-3	2021	Here we perform a functional screen of metabolic genes that rescue tumour cells from effector T cell cytotoxicity, and identify the embryo- and tumour-specific folate cycle enzyme methylenetetrahydrofolate dehydrogenase 2 (MTHFD2).	Folic Acid	160-166	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	Homo sapiens	180-221
33782411-3	2021	Here we perform a functional screen of metabolic genes that rescue tumour cells from effector T cell cytotoxicity, and identify the embryo- and tumour-specific folate cycle enzyme methylenetetrahydrofolate dehydrogenase 2 (MTHFD2).	Folic Acid	160-166	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	Homo sapiens	223-229
33782411-6	2021	Meanwhile, MTHFD2 drives the folate cycle to sustain sufficient uridine-related metabolites including UDP-GlcNAc, which promotes the global O-GlcNAcylation of proteins including cMYC, resulting in increased cMYC stability and PD-L1 transcription.	Folic Acid	29-35	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	Homo sapiens	11-17
33710891-2	2021	Accordingly, we have designed conjugates of folic acid with anticancer peptides able to bind human thymidylate synthase (hTS) and enter cancer cells through folate receptor alpha (FRalpha) highly expressed by several cancer cells.	Folic Acid	44-54	APC down-regulated 1	Homo sapiens	121-124
12089131-1	2002	We report on a child in whom severe nutritional vitamin B12 deficiency was exacerbated by a genetic impairment of the folate cycle, causing reduced CSF concentrations of the methyl group donor 5-methyltetrahydrofolate.	Folic Acid	118-124	colony stimulating factor 2	Homo sapiens	148-151
33220403-10	2021	Expression of genes in cholesterol synthesis, transport or turnover (Abcg5, Abcg8, Abcc2, Cyp46a1, Hmgcs1) was perturbed by high folic acid intake.	Folic Acid	129-139	cytochrome P450, family 46, subfamily a, polypeptide 1	Mus musculus	90-97
33024270-3	2021	Thymidylate synthase (TS) has been previously correlated with EMT transcription factor ZEB1 in NSCLC and imparts resistance against anti-folate chemotherapy.	Folic Acid	137-143	thymidylate synthase	Mus musculus	0-20
12095688-0	2002	The half-life of the transcript encoding the folate receptor alpha in KB cells is reduced by cytosolic proteins expressed in folate-replete and not in folate-depleted cells.	Folic Acid	125-131	folate receptor alpha	Homo sapiens	45-66
33024270-3	2021	Thymidylate synthase (TS) has been previously correlated with EMT transcription factor ZEB1 in NSCLC and imparts resistance against anti-folate chemotherapy.	Folic Acid	137-143	thymidylate synthase	Mus musculus	22-24
33068011-0	2021	Targeted inhibition of Rev-erbalpha/beta limits ferroptosis to ameliorate folic acid-induced acute kidney injury.	Folic Acid	74-84	nuclear receptor subfamily 1, group D, member 1	Mus musculus	23-40
12095688-1	2002	The KB cell, a transformed human cell line, constitutively expresses a high level of the glycosylphosphatidylinositol (GPI) anchored folate receptor protein alpha (FR alpha) and thereby can grow in medium containing &lt;1 nM folate.	Folic Acid	133-139	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	164-172
12095688-2	2002	When transferred from a folate-replete (FR) medium to one folate-deficient (FD), intracellular folate diminishes about 50-fold and expression of the FR alpha increases 6-fold.	Folic Acid	24-30	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	149-157
12095688-2	2002	When transferred from a folate-replete (FR) medium to one folate-deficient (FD), intracellular folate diminishes about 50-fold and expression of the FR alpha increases 6-fold.	Folic Acid	58-64	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	149-157
12095688-2	2002	When transferred from a folate-replete (FR) medium to one folate-deficient (FD), intracellular folate diminishes about 50-fold and expression of the FR alpha increases 6-fold.	Folic Acid	58-64	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	149-157
11941454-6	2002	Supplemental administration of low levels of ADCC-activating cytokines [e.g. interleukin-2 (IL-2) and interferon-alpha (IFN-alpha)] has been shown to synergize with the folate-targeted immunotherapy.	Folic Acid	169-175	interleukin 2	Mus musculus	77-90
11941454-6	2002	Supplemental administration of low levels of ADCC-activating cytokines [e.g. interleukin-2 (IL-2) and interferon-alpha (IFN-alpha)] has been shown to synergize with the folate-targeted immunotherapy.	Folic Acid	169-175	interleukin 2	Mus musculus	92-96
11941454-7	2002	Thus, using M109 syngeneic lung cancer cells injected intraperitoneally into Balb/c mice that were previously immunized against fluorescein, a significant extension of life span is observed following treatment with folate-fluorescein conjugates, and complete cures are observed upon supplementation with moderate levels of IL-2 and IFN-alpha.	Folic Acid	215-221	interleukin 2	Mus musculus	323-327
12678736-10	2002	FPGS activity on natural folate is essential to cell proliferation and survival.	Folic Acid	25-31	folylpolyglutamate synthase	Homo sapiens	0-4
12021520-2	2002	methylcobalamin (Me-Cbl), the coenzymatically active form of vitamin B12 that acts as a cofactor for methionine synthase in the conversion of total homocysteine (tHcy) to methionine, with or without oral folic acid (FA) supplementation, on fasting tHcy levels in hemodialysis (HD) patients.	Folic Acid	204-214	Cbl proto-oncogene	Homo sapiens	20-23
11880504-5	2002	When maintained on a folic acid-deficient diet, amyloid precursor protein (APP) mutant transgenic mice, but not wild-type mice, exhibited increased cellular DNA damage and hippocampal neurodegeneration.	Folic Acid	21-31	amyloid beta (A4) precursor protein	Mus musculus	48-73
11880504-7	2002	Our data suggest that folic acid deficiency and homocysteine impair DNA repair in neurons, which sensitizes them to oxidative damage induced by Abeta.	Folic Acid	22-32	amyloid beta (A4) precursor protein	Mus musculus	144-149
12187485-2	2002	Based on this, we hypothesized that folate would enter the RPE via FR alpha and exit the cell via RFT-1.	Folic Acid	36-42	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	67-75
12187485-8	2002	The presence of FR alpha in the basal membrane was demonstrable by folate binding and that of RFT-1 in the apical membrane by blockade of folate transport by RFT-1-specific antibody.	Folic Acid	67-73	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	16-24
12187485-8	2002	The presence of FR alpha in the basal membrane was demonstrable by folate binding and that of RFT-1 in the apical membrane by blockade of folate transport by RFT-1-specific antibody.	Folic Acid	138-144	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	16-24
11774112-9	2002	Thus, the PML defect was more responsive to folic acid in HD patients, whereas vitamin B6 partially reduced PML tHcy levels in patients with CRI.	Folic Acid	44-54	PML nuclear body scaffold	Homo sapiens	10-13
11756224-5	2002	In folate-adequate Min mice, we identified positive linear correlations between SAM or SAH and tumor numbers (R(2) = 0.38, P &lt; 0.005; R(2) = 0.26, P = 0.025, respectively).	Folic Acid	3-9	APC, WNT signaling pathway regulator	Mus musculus	19-22
11774738-2	2001	The cells acquired resistance to antifolate drug(s) through: (1) impaired drug uptake via the reduced folate carrier, (2) increased activity of the target enzymes[dihydrofolate reductase(DHFR) or thymidylate synthase(TS)] resulted from a concomitant amplification and overexpression of their gene, (3) induction of a variant DHFR with a low affinity for antifolate drug(s) used for the selection of resistance, and (4) defective polyglutamation.	Folic Acid	37-43	dihydrofolate reductase	Homo sapiens	325-329
11325838-1	2001	Plasma levels of folates and thymidine in mice are about 10-fold higher than in humans and may influence the therapeutic efficacy of thymidylate synthase (TS) inhibitors, such as 5-fluorouracil (5FU) and the antifolates pemetrexed (MTA) and raltitrexed (RTX).	Folic Acid	17-24	thymidylate synthetase	Homo sapiens	133-153
11388596-10	2001	Low CSF folate levels (13.9 and 12.6 ng/ml, reference range 15-40 ng/ml) and an alteration in the CSF/serum folate ratio (1.43 and 1.16, normal ratio 3:1) were also found as well as increased levels of cystathionine both in CSF (40 micromol/l, reference range 18-28 micromol/l) and in serum (32 micromol/l, reference value &lt;0.10 micromol/l).	Folic Acid	8-14	colony stimulating factor 2	Homo sapiens	4-7
11036056-1	2000	Many laboratory strains of Escherichia coli are resistant to methotrexate (MTX), a folate analogue that binds dihydrofolate reductase (DHFR).	Folic Acid	83-89	Dihydrofolate reductase	Escherichia coli	110-133
11036056-1	2000	Many laboratory strains of Escherichia coli are resistant to methotrexate (MTX), a folate analogue that binds dihydrofolate reductase (DHFR).	Folic Acid	83-89	Dihydrofolate reductase	Escherichia coli	135-139
11050010-7	2000	Both the S-phase accumulation and the apoptosis were induced by folate deficiency in erythroblasts from p53 null mice.	Folic Acid	64-70	transformation related protein 53, pseudogene	Mus musculus	104-107
11015690-1	2000	The new concept developed in this study is the design of poly(ethylene glycol) (PEG)-coated biodegradable nanoparticles coupled to folic acid to target the folate-binding protein; this molecule is the soluble form of the folate receptor that is overexpressed on the surface of many tumoral cells.	Folic Acid	131-141	folate receptor alpha	Homo sapiens	156-178
11015690-5	2000	Finally, the specific interaction between the conjugate folate-nanoparticles and the folate-binding protein was evaluated by surface plasmon resonance.	Folic Acid	56-62	folate receptor alpha	Homo sapiens	85-107
10955484-2	2000	Chromosome analysis showed the expression of the rare folate-sensitive fragile site FRA12A at 12q13 in 8/20 (40%) of blood lymphocytes cultured in folate-deficient medium in the presence of trimethoprim.	Folic Acid	54-60	fragile site, folic acid type, rare, fra(12)(q13.1)	Homo sapiens	84-90
31127676-0	2020	Effects of folic acid on oligozoospermia with MTHFR polymorphisms in term of seminal parameters, DNA fragmentation, and live birth rate: a double-blind, randomized, placebo-controlled trial.	Folic Acid	11-21	methylenetetrahydrofolate reductase	Homo sapiens	46-51
31127676-2	2020	However, there are few data concerning the influence of folic acid supplementation on male-factor infertility with MTHFR gene polymorphisms.	Folic Acid	56-66	methylenetetrahydrofolate reductase	Homo sapiens	115-120
31127676-3	2020	OBJECTIVES: To evaluate whether folic acid supplementation has a beneficial effect on oligozoospermia with MTHFR gene polymorphisms in Chinese infertility population.	Folic Acid	32-42	methylenetetrahydrofolate reductase	Homo sapiens	107-112
31127676-7	2020	RESULTS: Administration of folic acid for 3 months could significantly improve the seminal parameters in patients with MTHFR 677 TT genotype in comparison with that receiving placebo.	Folic Acid	27-37	methylenetetrahydrofolate reductase	Homo sapiens	119-124
31127676-9	2020	Spontaneous pregnancy rate and live birth rate tended to be significantly higher in couples in which the men with MTHFR 677 TT genotype receiving folic acid than that receiving placebo.	Folic Acid	146-156	methylenetetrahydrofolate reductase	Homo sapiens	114-119
31127676-12	2020	CONCLUSIONS: Folic acid supplementation has a beneficial effect on oligozoospermia with MTHFR 677 TT genotype in term of seminal parameters, seminal MDA, sperm DNA fragmentation, and pregnancy outcome.	Folic Acid	13-23	methylenetetrahydrofolate reductase	Homo sapiens	88-93
31446167-1	2020	PURPOSE: Methyltetrahydrofolate reductase (MTHFR) C677T (ala222Val) is a single-nucleotide polymorphism (SNP) that affects the formation of 5-methyltetrahydrofolate (5-MTHF), the active folate that allows the recycling of homocysteine (Hcy) to Methionine.	Folic Acid	25-31	methylenetetrahydrofolate reductase	Homo sapiens	43-48
31968288-1	2020	Methylene tetrahydrofolate reductase (MTHFR) is a flavoprotein, involved in one-carbon pathway and is responsible for folate and homocysteine metabolism.	Folic Acid	20-26	methylenetetrahydrofolate reductase	Homo sapiens	38-43
32239487-3	2020	ABO and Rhesus (Rh) blood groups, that share similar genetic localisations as folate mechanism, have relations with various metabolic and malignant diseases.	Folic Acid	78-84	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	0-3
33081452-3	2020	Genetic variants of the polymorphism of the folate metabolism enzyme methylenetetrahydrofolate reductase (MTHFR) 677C>T were determined using real-time PCR.	Folic Acid	44-50	methylenetetrahydrofolate reductase	Homo sapiens	69-104
33081452-3	2020	Genetic variants of the polymorphism of the folate metabolism enzyme methylenetetrahydrofolate reductase (MTHFR) 677C>T were determined using real-time PCR.	Folic Acid	44-50	methylenetetrahydrofolate reductase	Homo sapiens	106-111
31691569-3	2019	We hypothesize that offspring exposed to less folic acid will express higher levels of Pomc (proopiomelanocortin) gene mRNA.	Folic Acid	46-56	proopiomelanocortin	Rattus norvegicus	93-112
31691569-4	2019	AIM: to investigate the Pomc gene and protein expression pattern in the female offspring of female rats receiving a folic acid-deficient diet during gestation, lactation, and post-weaning.	Folic Acid	116-126	proopiomelanocortin	Rattus norvegicus	24-28
31691569-7	2019	RESULTS: the female offspring in the folic acid-deficient diet group had significantly higher Pomc gene and protein expression than the female offspring in the control diet group (p = 0.03, p = 0.01, respectively).	Folic Acid	37-47	proopiomelanocortin	Rattus norvegicus	94-98
31691569-8	2019	CONCLUSION: a folic acid-deficient diet during gestation, lactation, and post-weaning increases Pomc gene and protein expression, but does not modify food intake or body weight of female rat offspring.	Folic Acid	14-24	proopiomelanocortin	Rattus norvegicus	96-100
31817852-0	2019	Plasma Homocysteine and Polymorphisms of Genes Involved in Folate Metabolism Correlate with DNMT1 Gene Methylation Levels.	Folic Acid	59-65	DNA methyltransferase 1	Homo sapiens	92-97
31817852-3	2019	Dietary folates and related B-vitamins are essential micronutrients for DNA methylation processes, and we performed the present study to investigate the contribution of circulating folate, vitamin B12, homocysteine, and common polymorphisms in folate pathway genes to the DNMT1 gene methylation levels.	Folic Acid	8-15	DNA methyltransferase 1	Homo sapiens	272-277
31817852-9	2019	The present study revealed several correlations between the folate metabolic pathway and DNMT1 promoter methylation that could be of relevance for those disorders characterized by altered DNA methylation.	Folic Acid	60-66	DNA methyltransferase 1	Homo sapiens	89-94
31663297-1	2019	INTRODUCTION: Methylenetetrahydrofolate reductase (MTHFR) is essential in mediating folate metabolism, and thus plays an important role in diabetes and diabetic complications.	Folic Acid	33-39	methylenetetrahydrofolate reductase	Homo sapiens	51-56
31739474-5	2019	Moreover, the variability of the methylenetetrahydrofolate reductase gene, important in both folate metabolism and migraine pathogenesis, modulates the beneficial effects of folate for migraines.	Folic Acid	93-99	methylenetetrahydrofolate reductase	Homo sapiens	33-68
31624245-4	2019	Moreover, we found that MYCN mediated the folate cycle via MTHFD2, which contributed one-carbon unit to enhance purine synthesis, and further regulated nucleotide production by PAICS in response to cancer progression.	Folic Acid	42-48	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	Homo sapiens	59-65
31482954-1	2019	OBJECTIVE: To investigate the association of the genetic variants of the folate metabolism genes (MTHFR C677T; MTHFR A1298C; MTR A2756G; MTRR A66G and RFC-1 A80G) with the development of polycystic ovary syndrome (PCOS).	Folic Acid	73-79	methylenetetrahydrofolate reductase	Homo sapiens	98-103
31482954-1	2019	OBJECTIVE: To investigate the association of the genetic variants of the folate metabolism genes (MTHFR C677T; MTHFR A1298C; MTR A2756G; MTRR A66G and RFC-1 A80G) with the development of polycystic ovary syndrome (PCOS).	Folic Acid	73-79	methylenetetrahydrofolate reductase	Homo sapiens	111-116
31482954-1	2019	OBJECTIVE: To investigate the association of the genetic variants of the folate metabolism genes (MTHFR C677T; MTHFR A1298C; MTR A2756G; MTRR A66G and RFC-1 A80G) with the development of polycystic ovary syndrome (PCOS).	Folic Acid	73-79	replication factor C subunit 1	Homo sapiens	151-156
31381192-0	2019	Design and synthesis of leucine-linked quinazoline-4(3H)-one-sulphonamide molecules distorting malarial reductase activity in the folate pathway.	Folic Acid	130-136	malarial reductase	None	95-113
30546072-0	2019	Author Correction: ATF4 regulation of mitochondrial folate-mediated one-carbon metabolism is neuroprotective.	Folic Acid	52-58	activating transcription factor 4	Homo sapiens	19-23
31089058-0	2019	Corrigendum: A high methionine, low folate and vitamin B 6 /B 12 containing diet can be associated with memory loss by epigenetic silencing of netrin-1.	Folic Acid	36-42	netrin 1	Homo sapiens	143-151
31155015-8	2019	Optimising B-vitamin intake may be particularly important for sub-populations with impaired folate metabolism owing to genetic characteristics, most notably the 677C T variant in the gene encoding the enzyme methylenetetrahydrofolate reductase (MTHFR).	Folic Acid	92-98	methylenetetrahydrofolate reductase	Homo sapiens	208-243
31155015-8	2019	Optimising B-vitamin intake may be particularly important for sub-populations with impaired folate metabolism owing to genetic characteristics, most notably the 677C T variant in the gene encoding the enzyme methylenetetrahydrofolate reductase (MTHFR).	Folic Acid	92-98	methylenetetrahydrofolate reductase	Homo sapiens	245-250
31155015-9	2019	This common folate polymorphism is linked with several adverse health outcomes, including stroke, however, recent evidence has identified its novel interaction with riboflavin (the MTHFR cofactor) in relation to blood pressure and risk of developing hypertension.	Folic Acid	12-18	methylenetetrahydrofolate reductase	Homo sapiens	181-186
30916789-4	2019	Inborn errors of folate metabolism include deficiencies of the enzymes methylenetetrahydrofolate reductase, dihydrofolate reductase and 5,10-methenyltetrahydrofolate synthetase.	Folic Acid	17-23	methylenetetrahydrofolate reductase	Homo sapiens	71-106
31200713-2	2019	The aim of this study is to explore the effects of folate pathway gene polymorphisms (the 5-10-methylenetetrahydrofolate reductase, MTHTR C677T, MTHFR A1298C and the methionine synthase reductase, MTRR A66G) and their interactions with homocysteine on serum lipid levels in patients with RSA.	Folic Acid	51-57	methylenetetrahydrofolate reductase	Homo sapiens	145-150
30862944-0	2019	Regulation of folate and methionine metabolism by multisite phosphorylation of human methylenetetrahydrofolate reductase.	Folic Acid	14-20	methylenetetrahydrofolate reductase	Homo sapiens	85-120
30848279-2	2019	A key pathway of this metabolism is the vitamin B-12- and folate-dependent remethylation of homocysteine, which depends on methionine synthase (MS, encoded by MTR), methionine synthase reductase, and methylenetetrahydrofolate reductase.	Folic Acid	58-64	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	123-142
30848279-2	2019	A key pathway of this metabolism is the vitamin B-12- and folate-dependent remethylation of homocysteine, which depends on methionine synthase (MS, encoded by MTR), methionine synthase reductase, and methylenetetrahydrofolate reductase.	Folic Acid	58-64	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	144-146
30848279-2	2019	A key pathway of this metabolism is the vitamin B-12- and folate-dependent remethylation of homocysteine, which depends on methionine synthase (MS, encoded by MTR), methionine synthase reductase, and methylenetetrahydrofolate reductase.	Folic Acid	58-64	methylenetetrahydrofolate reductase	Homo sapiens	200-235
30670450-3	2019	A Rho-kinase deficient binding mutant of the apical constriction regulating protein, Shroom3 (Shroom3R1838C), is one of only a handful of mouse mutant lines with neural tube defects that can be rescued by folic acid supplementation.	Folic Acid	205-215	shroom family member 3	Mus musculus	85-92
30670450-3	2019	A Rho-kinase deficient binding mutant of the apical constriction regulating protein, Shroom3 (Shroom3R1838C), is one of only a handful of mouse mutant lines with neural tube defects that can be rescued by folic acid supplementation.	Folic Acid	205-215	shroom family member 3	Mus musculus	94-107
30670450-5	2019	Utilizing an epithelial cell culture model of apical constriction, it was observed that treatment with exogenous folic acid, as well as co-expression of the folic acid receptor Folr1, can rescue the function of the Rho-kinase binding deficient mutant of Shroom3 in vitro It was also determined that the rescuing ability of folic acid is RhoA and Rho-kinase independent but myosin light chain kinase (MLCK) and Src-kinase dependent.	Folic Acid	113-123	shroom family member 3	Mus musculus	254-261
30670450-5	2019	Utilizing an epithelial cell culture model of apical constriction, it was observed that treatment with exogenous folic acid, as well as co-expression of the folic acid receptor Folr1, can rescue the function of the Rho-kinase binding deficient mutant of Shroom3 in vitro It was also determined that the rescuing ability of folic acid is RhoA and Rho-kinase independent but myosin light chain kinase (MLCK) and Src-kinase dependent.	Folic Acid	157-167	shroom family member 3	Mus musculus	254-261
33405856-0	2019	Folic-Acid-Adorned PEGylated Graphene Oxide Interferes with the Cell Migration of Triple Negative Breast Cancer Cell Line, MDAMB-231 by Targeting miR-21/PTEN Axis through NFkappaB.	Folic Acid	0-10	microRNA 21	Gallus gallus	146-152
30080444-1	2019	One-carbon metabolism provides a direct link among dietary folate/vitamin B12 exposure, the activity of the enzyme methylenetetrahydrofolate reductase (MTHFR), and epigenetic regulation of the genome via DNA methylation.	Folic Acid	59-65	methylenetetrahydrofolate reductase	Homo sapiens	115-150
30080444-1	2019	One-carbon metabolism provides a direct link among dietary folate/vitamin B12 exposure, the activity of the enzyme methylenetetrahydrofolate reductase (MTHFR), and epigenetic regulation of the genome via DNA methylation.	Folic Acid	59-65	methylenetetrahydrofolate reductase	Homo sapiens	152-157
30080444-2	2019	Previously, it has been shown that the common c.677C &gt; T polymorphism in MTHFR influences global DNA methylation status through a direct interaction with folate status and (indirectly) with total homocysteine (tHcy) levels.	Folic Acid	157-163	methylenetetrahydrofolate reductase	Homo sapiens	76-81
30451038-3	2019	The MTHFR gene is one of the few replicated genetic risk factors for migraine and encodes an enzyme that is crucial for the folate and the methionine cycles.	Folic Acid	124-130	methylenetetrahydrofolate reductase	Homo sapiens	4-9
31902858-2	2019	Folate and vitamin B12 are key elements of the one-carbon metabolism pathway where methylenetetrahydrofolate reductase (MTHFR) plays a significant role.	Folic Acid	0-6	methylenetetrahydrofolate reductase	Homo sapiens	83-118
31902858-2	2019	Folate and vitamin B12 are key elements of the one-carbon metabolism pathway where methylenetetrahydrofolate reductase (MTHFR) plays a significant role.	Folic Acid	0-6	methylenetetrahydrofolate reductase	Homo sapiens	120-125
31902858-4	2019	By reviewing the relevant literatures and summarizing the potential effect of dietary folate intake on MTHFR genes polymorphism and breast cancer risk, we conclude that MTHFR C677T gene polymorphism is associated with breast cancer risk among Asian, but not Caucasians, and the MTHFR A1298C gene polymorphism is not a susceptibility factor of breast cancers.	Folic Acid	86-92	methylenetetrahydrofolate reductase	Homo sapiens	103-108
31902858-4	2019	By reviewing the relevant literatures and summarizing the potential effect of dietary folate intake on MTHFR genes polymorphism and breast cancer risk, we conclude that MTHFR C677T gene polymorphism is associated with breast cancer risk among Asian, but not Caucasians, and the MTHFR A1298C gene polymorphism is not a susceptibility factor of breast cancers.	Folic Acid	86-92	methylenetetrahydrofolate reductase	Homo sapiens	169-174
31902858-4	2019	By reviewing the relevant literatures and summarizing the potential effect of dietary folate intake on MTHFR genes polymorphism and breast cancer risk, we conclude that MTHFR C677T gene polymorphism is associated with breast cancer risk among Asian, but not Caucasians, and the MTHFR A1298C gene polymorphism is not a susceptibility factor of breast cancers.	Folic Acid	86-92	methylenetetrahydrofolate reductase	Homo sapiens	169-174
31902858-5	2019	Concomitant low activity of MTHFR enzyme resulted from C677T gene polymorphism and low dietary folate intake is associated with increased breast cancer risk.	Folic Acid	95-101	methylenetetrahydrofolate reductase	Homo sapiens	28-33
30633186-1	2019	RATIONALE: Hereditary hyperhomocysteinemia results from a polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene that reduces folate metabolism.	Folic Acid	97-103	methylenetetrahydrofolate reductase	Homo sapiens	115-120
30468411-1	2019	AIM: 5,10-MTHFR-single nucleotide polymorphisms are important for normal functioning of the enzyme that plays a key role in DNA synthesis, folate metabolism and methylation reactions.	Folic Acid	139-145	methylenetetrahydrofolate reductase	Homo sapiens	10-15
30500180-5	2018	On the other hand, a detailed comparison of their catalytic and regulatory properties is missing, although this aspect seems to be considerably important, considering that SHMT1 and SHMT2 reside in different cellular compartments, where they play distinct roles in folate metabolism.	Folic Acid	265-271	serine hydroxymethyltransferase 2	Homo sapiens	182-187
30228213-11	2018	5-Methyltetrahydrofolate, the main form of folate found in blood, is essential for the vitamin B12-dependent methionine synthase mediated remethylation of homocysteine to methionine.	Folic Acid	18-24	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	87-128
30405444-0	2018	Fibroblast Growth Factor 23 Expression Is Increased in Multiple Organs in Mice With Folic Acid-Induced Acute Kidney Injury.	Folic Acid	84-94	fibroblast growth factor 23	Mus musculus	0-27
29953918-2	2018	Some loci and genes that are associated with folate levels had been detected by genome-wide association studies (GWAS), such as rs1801133 in MTHFR and rs1979277 in SHMT1.	Folic Acid	45-51	methylenetetrahydrofolate reductase	Homo sapiens	141-146
29953918-7	2018	RESULTS: We validated that rs1801133 in MTHFR was significantly involved in serum folate (P = 4.21 x 10-19).	Folic Acid	82-88	methylenetetrahydrofolate reductase	Homo sapiens	40-45
30337500-1	2018	Methionine synthase (METH, i.e., MTR) is a key enzyme in the folate pathway, which plays a critical role in the synthesis, repair, and methylation of DNA.	Folic Acid	61-67	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	0-19
30337500-1	2018	Methionine synthase (METH, i.e., MTR) is a key enzyme in the folate pathway, which plays a critical role in the synthesis, repair, and methylation of DNA.	Folic Acid	61-67	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	21-25
29427035-10	2018	In conclusion, Lactobacillus and folic acid in a mixture with cadmium acted beneficially to an organism, increasing the cadmium excretion in feces, and consequently increasing beta-catenin and BDNF in brain tissue and StAR and 17-beta HSD in testis and improving their functions.	Folic Acid	33-43	catenin (cadherin associated protein), beta 1	Mus musculus	176-188
29427035-10	2018	In conclusion, Lactobacillus and folic acid in a mixture with cadmium acted beneficially to an organism, increasing the cadmium excretion in feces, and consequently increasing beta-catenin and BDNF in brain tissue and StAR and 17-beta HSD in testis and improving their functions.	Folic Acid	33-43	hydroxysteroid (17-beta) dehydrogenase 1	Mus musculus	227-238
30578914-7	2018	Notably, defective variants in MTHFR and RBP4, two genes involved in folic acid and vitamin A biosynthesis, were found to have high contributions to NSCL/P incidence based on feature importance evaluation with logistic regression.	Folic Acid	69-79	methylenetetrahydrofolate reductase	Homo sapiens	31-36
30578914-7	2018	Notably, defective variants in MTHFR and RBP4, two genes involved in folic acid and vitamin A biosynthesis, were found to have high contributions to NSCL/P incidence based on feature importance evaluation with logistic regression.	Folic Acid	69-79	retinol binding protein 4	Homo sapiens	41-45
30064014-0	2018	Folic acid supplementation during pregnancy prevents cognitive impairments and BDNF imbalance in the hippocampus of the offspring after neonatal hypoxia-ischemia.	Folic Acid	0-10	brain-derived neurotrophic factor	Rattus norvegicus	79-83
29803102-5	2018	The accuracy was evaluated by assessing the polymorphisms of methylenetetrahydrofolate reductase (MTHFR) C677T and aldehyde dehydrogenase-2 (ALDH2) Glu504Lys, which are better known for their critical role in folate and ethanol metabolism, respectively.	Folic Acid	80-86	methylenetetrahydrofolate reductase	Homo sapiens	98-103
29861060-2	2018	Mice with folic acid-induced AKI had an increase in bone FGF23 mRNA expression together with an increase in serum FGF23 and several circulating cytokines including interleukin-6 (IL-6).	Folic Acid	10-20	fibroblast growth factor 23	Mus musculus	57-62
29861060-2	2018	Mice with folic acid-induced AKI had an increase in bone FGF23 mRNA expression together with an increase in serum FGF23 and several circulating cytokines including interleukin-6 (IL-6).	Folic Acid	10-20	fibroblast growth factor 23	Mus musculus	114-119
29992403-11	2018	CONCLUSIONS: Folic acid-conjugated 17-AAG magnetic thermosensitive liposomes in combination with an alternating magnetic field for heating can achieve a synergistic anti-tumor effect of chemotherapy and heat treatment, potentially offering a new method for ovarian cancer treatment.	Folic Acid	13-23	N-methylpurine DNA glycosylase	Homo sapiens	38-41
30084801-3	2018	Methionine synthase (MTR), a key enzyme of folate metabolism, is involved in the early embryonic development.	Folic Acid	43-49	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	0-19
29732722-10	2018	Eight more candidate genes (Abcc3, Gsr, Gclc, Mthfd1, Gart, Bche, Slc25a32, and Slc44a2) were identified by examining the DEGs of those genes involved in the extended folate metabolic pathway between FA-responsive and FA-resistant mutants.	Folic Acid	167-173	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	Mus musculus	28-33
29564022-13	2018	This may be due to small sample sizes or folate repletion in our Canadian population attenuating effects of the high-risk MTHFR variants.	Folic Acid	41-47	methylenetetrahydrofolate reductase	Homo sapiens	122-127
29107049-2	2018	In this study, I addressed this issue and focused on the synthesis and characterization of pH-responsive Fe3O4@SiO2(FITC)-BTN/folic acid/DOX multifunctional nanoparticles aiming to increase drug accumulation in malignancies with both dual active targeting and endosomal drug release properties.	Folic Acid	126-136	butyrophilin subfamily 1 member A1	Homo sapiens	122-125
29474406-10	2018	Irrespective of cancer status, several SNPs were found to be associated with altered serum folate concentrations, including the D919G SNP in methionine synthase (MTR), the L474F SNP in serine hydroxymethyl transferase 1 (SHMT1) and the V175M SNP in phosphatidyl ethanolamine methyltransferase (PEMT).	Folic Acid	91-97	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	141-160
29474406-11	2018	Further, the V allele of the A222V SNP and the E allele of the E429A SNP in methylene tetrahydrofolate reductase (MTHFR) were associated with low RBC folate levels.	Folic Acid	96-102	methylenetetrahydrofolate reductase	Homo sapiens	114-119
29474406-12	2018	Pancreatic cancer risk was found to be significantly lower for the LL allele of the L78R SNP in choline dehydrogenase (CHDH; OR = 0.29; 95% CI 0.12-0.76); however, it was not associated with altered serum or RBC folate levels.	Folic Acid	212-218	choline dehydrogenase	Homo sapiens	96-117
29474406-12	2018	Pancreatic cancer risk was found to be significantly lower for the LL allele of the L78R SNP in choline dehydrogenase (CHDH; OR = 0.29; 95% CI 0.12-0.76); however, it was not associated with altered serum or RBC folate levels.	Folic Acid	212-218	choline dehydrogenase	Homo sapiens	119-123
29117460-1	2018	BACKGROUND: Folic acid supplement use during pregnancy might affect childhood respiratory health, potentially mediated by methylenetetrahydrofolate reductase polymorphism C677T (MTHFR-C677T) carriership.	Folic Acid	12-22	methylenetetrahydrofolate reductase	Homo sapiens	122-157
29342488-8	2018	The current meta-analysis showed folate supplementation among patients with metabolic diseases significantly decreased insulin (SMD -1.28; 95% CI, -1.99, -0.56) and homeostasis model assessment of insulin resistance (HOMA-IR) (SMD -1.28; 95% CI, -1.99, -0.56).	Folic Acid	33-39	small nuclear ribonucleoprotein D1 polypeptide	Homo sapiens	128-134
29342488-8	2018	The current meta-analysis showed folate supplementation among patients with metabolic diseases significantly decreased insulin (SMD -1.28; 95% CI, -1.99, -0.56) and homeostasis model assessment of insulin resistance (HOMA-IR) (SMD -1.28; 95% CI, -1.99, -0.56).	Folic Acid	33-39	small nuclear ribonucleoprotein D1 polypeptide	Homo sapiens	227-233
29109127-4	2018	The regulatory locus also expresses two functional RNAs, LINC00925-RNA and MIR9-3, which are coexpressed with POLG The MIR9-3 targets include NR2E1, a transcription factor maintaining neural stem cells in undifferentiated state, and MTHFD2, the regulatory enzyme of mitochondrial folate cycle, linking POLG expression to stem cell differentiation and folate metabolism.	Folic Acid	280-286	nuclear receptor subfamily 2 group E member 1	Homo sapiens	142-147
29109127-4	2018	The regulatory locus also expresses two functional RNAs, LINC00925-RNA and MIR9-3, which are coexpressed with POLG The MIR9-3 targets include NR2E1, a transcription factor maintaining neural stem cells in undifferentiated state, and MTHFD2, the regulatory enzyme of mitochondrial folate cycle, linking POLG expression to stem cell differentiation and folate metabolism.	Folic Acid	351-357	nuclear receptor subfamily 2 group E member 1	Homo sapiens	142-147
29865064-10	2018	Deregulation of AbetaPP provides a novel mechanism by which common human MTHFR polymorphisms may interact with dietary folate deficiency to alter neuronal homeostasis and increase the risk for sporadic AD.	Folic Acid	119-125	methylenetetrahydrofolate reductase	Homo sapiens	73-78
28374953-1	2018	BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR; NM_005957.4) is the key enzyme for folate metabolism which plays in DNA biosynthesis and the epigenetic process of DNA methylation.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	49-54
29848858-4	2018	We found that exposure to bisphenol A or folate deficiency during the fetal period changes the expressions of Xist, Tsix (the antisense repressor of Xist), and many X chromosome linked genes widely in newborn mice.	Folic Acid	41-47	inactive X specific transcripts	Mus musculus	110-114
29848858-4	2018	We found that exposure to bisphenol A or folate deficiency during the fetal period changes the expressions of Xist, Tsix (the antisense repressor of Xist), and many X chromosome linked genes widely in newborn mice.	Folic Acid	41-47	inactive X specific transcripts	Mus musculus	149-153
28984369-7	2018	Very high levels of maternal plasma folate at birth (&gt;=60.3 nmol/L) had 2.5 times increased risk of ASD [95% confidence interval (CI) 1.3, 4.6] compared to folate levels in the middle 80th percentile, after adjusting for covariates including MTHFR genotype.	Folic Acid	36-42	methylenetetrahydrofolate reductase	Homo sapiens	245-250
29544641-2	2018	TS is involved in the folate pathways, specifically in the de novo pyrimidine biosynthesis.	Folic Acid	22-28	APC down-regulated 1	Homo sapiens	0-2
29246599-1	2017	BACKGROUND: Methylenetetrahydrofolate-reductase (MTHFR) deficiency is a rare autosomal recessive disorder affecting intracellular folate metabolism with affection of different organ systems and clinical manifestation usually in childhood.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	49-54
29545912-1	2018	5,10-Methylenetrahydrofolate reductase (MTHFR), a key enzyme for folate metabolism, catalyses the irreversible conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, which is located at the end of the short arm (1p36.3).	Folic Acid	22-28	methylenetetrahydrofolate reductase	Homo sapiens	40-45
28820331-1	2017	Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme regulating the folate cycle and its genetic variations have been associated with various human diseases.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
28820331-11	2017	Collectively, we have unveiled a vital role of PLK1-dependent phosphorylation of MTHFR in replication via histone methylation, and implicate folate metabolism with glioma.	Folic Acid	141-147	polo like kinase 1	Homo sapiens	47-51
28361455-1	2017	Methotrexate (MTX; an anti-folate) and etanercept (ET; a TNF-alpha inhibitor) are used against arthritis; however, limitations like short biological half-life, low cutaneous absorption, and acidic instability limit their clinical relevance.	Folic Acid	27-33	metaxin 1	Mus musculus	14-17
28780092-9	2017	Hepatic gene expression of methylmalonyl-CoA mutase and S-adenosylhomocysteine hydrolase was higher for cows receiving the combined folic acid and vitamin B12 supplement compared with cows receiving only the supplement of folic acid, whereas no treatment effect was noted for cows not receiving the folic acid supplement.	Folic Acid	132-142	methylmalonyl-CoA mutase	Bos taurus	27-51
28780092-9	2017	Hepatic gene expression of methylmalonyl-CoA mutase and S-adenosylhomocysteine hydrolase was higher for cows receiving the combined folic acid and vitamin B12 supplement compared with cows receiving only the supplement of folic acid, whereas no treatment effect was noted for cows not receiving the folic acid supplement.	Folic Acid	222-232	methylmalonyl-CoA mutase	Bos taurus	27-51
28780092-9	2017	Hepatic gene expression of methylmalonyl-CoA mutase and S-adenosylhomocysteine hydrolase was higher for cows receiving the combined folic acid and vitamin B12 supplement compared with cows receiving only the supplement of folic acid, whereas no treatment effect was noted for cows not receiving the folic acid supplement.	Folic Acid	222-232	methylmalonyl-CoA mutase	Bos taurus	27-51
29026722-1	2017	OBJECTIVE: To identify the associations between polymorphisms of the 3"-untranslated region (UTR) of methylenetetrahydrofolate reductase (MTHFR) gene, which codes for an important regulatory enzyme primarily involved in folate metabolism, and idiopathic recurrent pregnancy loss (RPL) in Korean women.	Folic Acid	120-126	methylenetetrahydrofolate reductase	Homo sapiens	138-143
29026722-6	2017	Analysis of variance revealed that MTHFR 4869C&gt;G was associated with altered CD56+ natural killer cell percentages (CC, 17.91%+-8.04%; CG, 12.67%+-4.64%; p=0.024) and folate levels (CC, 12.01+-7.18 mg/mL; CG, 22.15+-26.25 mg/mL; p=0.006).	Folic Acid	170-176	methylenetetrahydrofolate reductase	Homo sapiens	35-40
28598562-5	2017	Serum folate and total Hcy (tHcy) levels are influenced by folate intake and genetic polymorphisms in 5,10-methylenetertahydrofolate reductase (MTHFR) such as C677T.	Folic Acid	6-12	methylenetetrahydrofolate reductase	Homo sapiens	102-142
26991917-9	2017	Our data suggest a protective effect in participants with MTHFR TT genotype and low folate levels.	Folic Acid	84-90	methylenetetrahydrofolate reductase	Homo sapiens	58-63
28464292-6	2017	In this study, we evaluated the influence of effective ITPA down-regulation on the induction of apoptosis in a human cancer cell line using folate-single wall nanotubes (SWNT) as a targeted nanocarrier.	Folic Acid	140-146	inosine triphosphatase	Homo sapiens	55-59
28432198-6	2017	We propose that folic acid promotes normal NTC in some embryos by regulating the methylation of septin2, which is critical for normal cilium formation during early embryonic development.-Toriyama, M., Toriyama, M., Wallingford, J.	Folic Acid	16-26	septin 2	Homo sapiens	96-103
28534241-3	2017	Genome-wide association studies (GWAS) revealed that human folate level could be significantly influenced by fidgetin (FIGN), methylenetetrahydrofolate reductase (MTHFR), prickle homolog 2 (PRICKLE2), synaptotagmin 9 (SYT9), gamma-aminobutyric acid B receptor 2 (GABBR2), and alkaline phosphatase (ALPL) genes.	Folic Acid	59-65	methylenetetrahydrofolate reductase	Homo sapiens	126-161
28534241-3	2017	Genome-wide association studies (GWAS) revealed that human folate level could be significantly influenced by fidgetin (FIGN), methylenetetrahydrofolate reductase (MTHFR), prickle homolog 2 (PRICKLE2), synaptotagmin 9 (SYT9), gamma-aminobutyric acid B receptor 2 (GABBR2), and alkaline phosphatase (ALPL) genes.	Folic Acid	59-65	methylenetetrahydrofolate reductase	Homo sapiens	163-168
28534241-3	2017	Genome-wide association studies (GWAS) revealed that human folate level could be significantly influenced by fidgetin (FIGN), methylenetetrahydrofolate reductase (MTHFR), prickle homolog 2 (PRICKLE2), synaptotagmin 9 (SYT9), gamma-aminobutyric acid B receptor 2 (GABBR2), and alkaline phosphatase (ALPL) genes.	Folic Acid	59-65	prickle planar cell polarity protein 2	Homo sapiens	171-188
28534241-3	2017	Genome-wide association studies (GWAS) revealed that human folate level could be significantly influenced by fidgetin (FIGN), methylenetetrahydrofolate reductase (MTHFR), prickle homolog 2 (PRICKLE2), synaptotagmin 9 (SYT9), gamma-aminobutyric acid B receptor 2 (GABBR2), and alkaline phosphatase (ALPL) genes.	Folic Acid	59-65	prickle planar cell polarity protein 2	Homo sapiens	190-198
28748002-0	2017	High levels of circulating folate concentrations are associated with DNA methylation of tumor suppressor and repair genes p16, MLH1, and MGMT in elderly Chileans.	Folic Acid	27-33	O-6-methylguanine-DNA methyltransferase	Homo sapiens	137-141
28748002-4	2017	RESULTS: We found that serum folate and to a lesser extent, vitamin B12 concentrations, were significantly correlated with DNA methylation of p16, MLH1, and MGMT, but not with LINE-1.	Folic Acid	29-35	O-6-methylguanine-DNA methyltransferase	Homo sapiens	157-161
28915669-7	2017	In conclusion, our meta-analysis suggests that two folate metabolism genetic variants MTRR A66G (rs1801394) and MTHFR A1298C (rs1801131) contribute to genetic susceptibility to meningioma and glioma in adults.	Folic Acid	51-57	methylenetetrahydrofolate reductase	Homo sapiens	112-117
28587068-8	2017	The homocysteine concentrations increased in the CT and TT compared to CC genotypes of polymorphism MTHFR 677C&gt;T in all populations, and differences between the homocysteine concentrations according to the genotypes of MTHFR 677C&gt;T were observed regardless of folate level.	Folic Acid	266-272	methylenetetrahydrofolate reductase	Homo sapiens	100-105
28475147-0	2017	Folic Acid Supplementation Delays Atherosclerotic Lesion Development by Modulating MCP1 and VEGF DNA Methylation Levels In Vivo and In Vitro.	Folic Acid	0-10	chemokine (C-C motif) ligand 2	Mus musculus	83-87
28475147-0	2017	Folic Acid Supplementation Delays Atherosclerotic Lesion Development by Modulating MCP1 and VEGF DNA Methylation Levels In Vivo and In Vitro.	Folic Acid	0-10	vascular endothelial growth factor A	Mus musculus	92-96
28475147-7	2017	The underlying folic acid protective mechanism appears to operate through regulating the normal homocysteine state, upregulating the SAM: SAH ratio, elevating DNA methyltransferase activity and expression, altering MCP1 and VEGF promoter methylation, and inhibiting MCP1 and VEGF expression.	Folic Acid	15-25	chemokine (C-C motif) ligand 2	Mus musculus	215-219
28475147-7	2017	The underlying folic acid protective mechanism appears to operate through regulating the normal homocysteine state, upregulating the SAM: SAH ratio, elevating DNA methyltransferase activity and expression, altering MCP1 and VEGF promoter methylation, and inhibiting MCP1 and VEGF expression.	Folic Acid	15-25	vascular endothelial growth factor A	Mus musculus	224-228
28475147-7	2017	The underlying folic acid protective mechanism appears to operate through regulating the normal homocysteine state, upregulating the SAM: SAH ratio, elevating DNA methyltransferase activity and expression, altering MCP1 and VEGF promoter methylation, and inhibiting MCP1 and VEGF expression.	Folic Acid	15-25	chemokine (C-C motif) ligand 2	Mus musculus	266-270
28475147-7	2017	The underlying folic acid protective mechanism appears to operate through regulating the normal homocysteine state, upregulating the SAM: SAH ratio, elevating DNA methyltransferase activity and expression, altering MCP1 and VEGF promoter methylation, and inhibiting MCP1 and VEGF expression.	Folic Acid	15-25	vascular endothelial growth factor A	Mus musculus	275-279
28302752-10	2017	Minor C allele carriers who had decreased plasma folate levels exhibited significantly increased FIGN expression because the transcription suppressor CREB1 did not bind the alternative promoter of FIGN isoform X3.	Folic Acid	49-55	cAMP responsive element binding protein 1	Homo sapiens	150-155
28724269-1	2017	Methionine synthase (MTR) is one of the key enzymes of folate pathway, which play a key role in the construction, repair, and methylation of DNA.	Folic Acid	55-61	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	0-19
28422052-0	2017	Folic Acid Reduces Tau Phosphorylation by Regulating PP2A Methylation in Streptozotocin-Induced Diabetic Mice.	Folic Acid	0-10	protein phosphatase 2, regulatory subunit A, alpha	Mus musculus	53-57
28422052-13	2017	In addition, PP2A methylation and DNMT1 mRNA expression were significantly increased in DM mice post folic acid treatment.	Folic Acid	101-111	protein phosphatase 2, regulatory subunit A, alpha	Mus musculus	13-17
28422052-15	2017	Folic acid can reduce tau phosphorylation by regulating PP2A methylation in diabetic mice.	Folic Acid	0-10	protein phosphatase 2, regulatory subunit A, alpha	Mus musculus	56-60
28397480-1	2017	BACKGROUND: Methylene tetrahydrofolate reductase (MTHFR) is the key enzyme of folic acid metabolism and the C677T mutation is associated with decreased enzyme activity.	Folic Acid	78-88	methylenetetrahydrofolate reductase	Homo sapiens	12-48
28397480-1	2017	BACKGROUND: Methylene tetrahydrofolate reductase (MTHFR) is the key enzyme of folic acid metabolism and the C677T mutation is associated with decreased enzyme activity.	Folic Acid	78-88	methylenetetrahydrofolate reductase	Homo sapiens	50-55
28259896-4	2017	In the folate cycle, glycine and serine fuel the mitochondrial enzymes SHMT2, MTHFD2 and ALDH1L2, which play critical roles in the cancer survival and proliferation presumably through purine production.	Folic Acid	7-13	serine hydroxymethyltransferase 2	Homo sapiens	71-76
28259896-4	2017	In the folate cycle, glycine and serine fuel the mitochondrial enzymes SHMT2, MTHFD2 and ALDH1L2, which play critical roles in the cancer survival and proliferation presumably through purine production.	Folic Acid	7-13	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	Homo sapiens	78-84
28540268-3	2017	This study was done to compare the effects of high dose (5mg/day) and low dose (0.5 mg/day) folic acid in the RANKL/OPG ratio and Tumor Necrosis Factoralpha (TNFalpha) concentration during pregnancy.	Folic Acid	92-102	TNF superfamily member 11	Homo sapiens	110-115
28407838-13	2017	The methylation levels of IGF-1R, IGF-2R, IGFBP-2, IGFBP-5, IGFBP-6 and IGFBP-7 in the fetal brain were higher in the folate deficient group than in the control group (P&lt;0.05).	Folic Acid	118-124	insulin-like growth factor 2 receptor	Rattus norvegicus	34-40
28407838-15	2017	The methylation of IGF-2 gene showed a significant reduction in the folate deficient group (P&lt;0.05).	Folic Acid	68-74	insulin-like growth factor 2	Rattus norvegicus	19-24
27669293-6	2016	Gene expression analysis showed increased mRNA levels of peroxisome proliferator-activated receptor gamma (PPARgamma) and some of its target genes in adipose tissue of high fat-excess folic acid (HF-EFA) fed rats.	Folic Acid	184-194	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	57-105
27669293-6	2016	Gene expression analysis showed increased mRNA levels of peroxisome proliferator-activated receptor gamma (PPARgamma) and some of its target genes in adipose tissue of high fat-excess folic acid (HF-EFA) fed rats.	Folic Acid	184-194	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	107-116
27706773-1	2016	Activity of methylenetetrahydrofolate reductase (MTHFR), an enzyme involved in folate metabolism, is influenced by mutations in the corresponding gene, contributing to a decrease in 5,10-MTHF.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	49-54
27649570-1	2016	Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
27618097-7	2016	Meanwhile, folic acid increased the levels of ADAM9 and ADAM10, which are important alpha-secretases in ADAM (a disintegrin and metalloprotease) family.	Folic Acid	11-21	a disintegrin and metallopeptidase domain 9 (meltrin gamma)	Mus musculus	46-51
27618097-9	2016	Moreover, folic acid regulated the expression of miR-126-3p and miR-339-5p, which target ADAM9 and BACE1, respectively.	Folic Acid	10-20	a disintegrin and metallopeptidase domain 9 (meltrin gamma)	Mus musculus	89-94
26879954-1	2016	PURPOSE: Methylenetetrahydrofolate reductase (MTHFR) plays an important role in determining the proportions of folate coenzymes for DNA synthesis or DNA methylation.	Folic Acid	28-34	methylenetetrahydrofolate reductase	Homo sapiens	46-51
27585654-1	2016	BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR), a critical enzyme in folate metabolism is involved in DNA synthesis, DNA repair and DNA methylation.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	49-54
27363740-8	2016	The patient with MTHFR deficiency had extremely low 5MTHF and moderately low total folate; these values were not associated and showed no significant change after folic acid supplementation.	Folic Acid	83-89	methylenetetrahydrofolate reductase	Homo sapiens	17-22
27363740-8	2016	The patient with MTHFR deficiency had extremely low 5MTHF and moderately low total folate; these values were not associated and showed no significant change after folic acid supplementation.	Folic Acid	163-173	methylenetetrahydrofolate reductase	Homo sapiens	17-22
27659321-1	2016	Methylenetetrahydrofolate reductase (MTHFR) is the most important gene that participates in folate metabolism.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
27122634-9	2016	This folate transport was inhibited by dynasore, an inhibitor of endocytosis, but insensitive to the anion transport inhibitor stilbene 4-acetamido-40-isothiocyanato-stilbene-2,20-disulfonic acid, consistent with folate receptor-mediated transport but not with RFC1-mediated transport.	Folic Acid	5-11	solute carrier family 19 (folate transporter), member 1	Mus musculus	261-265
27187171-9	2016	A strong association between Hhcy and MTHFR TT genotype was observed (OR = 7.7, 95%CI:2.8-20.9) where all beta-TM patients with TT genotype were hyperhomocystienemic (&gt;= 15 mumol/l) and having sub-optimal folate level than those with CT or CC genotypes.	Folic Acid	208-214	methylenetetrahydrofolate reductase	Homo sapiens	38-43
26961134-8	2016	Four DM CpGs identified by SNPs in MTRR, MTHFR, and FTHFD were significantly associated with alcohol consumption and/or breast folate.	Folic Acid	127-133	methylenetetrahydrofolate reductase	Homo sapiens	41-46
27339384-3	2016	The renal cell expression of TWEAK and Fn14 is increased in human and experimental AKI and targeting TWEAK or Fn14 by genetic means or neutralizing antibodies was protective in kidney injury induced by folic acid overdose, ischemia-reperfusion, or unilateral ureteral obstruction.	Folic Acid	202-212	TNF superfamily member 12	Homo sapiens	29-34
27339384-3	2016	The renal cell expression of TWEAK and Fn14 is increased in human and experimental AKI and targeting TWEAK or Fn14 by genetic means or neutralizing antibodies was protective in kidney injury induced by folic acid overdose, ischemia-reperfusion, or unilateral ureteral obstruction.	Folic Acid	202-212	TNF superfamily member 12	Homo sapiens	101-106
26784656-6	2016	ANN simulations revealed that increased folate might restore ER and PR expression and reduce the promoter CpG island methylation of extra cellular superoxide dismutase and BRCA1.	Folic Acid	40-46	BRCA1 DNA repair associated	Homo sapiens	172-177
26784656-7	2016	Dietary intake of folate appears to confer protection against breast cancer through its modulating effects on ER and PR expression and methylation of EC-SOD and BRCA1.	Folic Acid	18-24	BRCA1 DNA repair associated	Homo sapiens	161-166
26961928-12	2016	Folate was significantly associated with lower risk of incident GA among subjects homozygous for the complement component 3 (C3) R102G rs2230199 nonrisk genotype (CC) (HR = 0.43; 95% CI: 0.27, 0.70; P = 0.0005) but not subjects carrying the risk allele (G) (P = 0.76).	Folic Acid	0-6	complement C3	Homo sapiens	101-123
26961928-12	2016	Folate was significantly associated with lower risk of incident GA among subjects homozygous for the complement component 3 (C3) R102G rs2230199 nonrisk genotype (CC) (HR = 0.43; 95% CI: 0.27, 0.70; P = 0.0005) but not subjects carrying the risk allele (G) (P = 0.76).	Folic Acid	0-6	complement C3	Homo sapiens	125-127
27025471-1	2016	Methylenetetrahydrofolate reductase (MTHFR) is the key enzyme of folate/homocysteine metabolic pathway.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
27301196-0	2016	Folate-Modified Chitosan Nanoparticles Coated Interferon-Inducible Protein-10 Gene Enhance Cytotoxic T Lymphocytes" Responses to Hepatocellular Carcinoma.	Folic Acid	0-6	C-X-C motif chemokine ligand 10	Homo sapiens	46-77
27301196-5	2016	Folate-modified chitosan nanoparticles coating the human IP-10 gene (FA-CS-hIP-10) were therefore developed in this study.	Folic Acid	0-6	C-X-C motif chemokine ligand 10	Homo sapiens	57-62
27301196-5	2016	Folate-modified chitosan nanoparticles coating the human IP-10 gene (FA-CS-hIP-10) were therefore developed in this study.	Folic Acid	0-6	C-X-C motif chemokine ligand 10	Homo sapiens	75-81
26706181-13	2016	In the folic acid (FA) group, levels of serum BDNF decreased statistically significantly compared to the PHT group.	Folic Acid	7-17	brain-derived neurotrophic factor	Rattus norvegicus	46-50
26706181-17	2016	About the increase level of BDNF, LTG is much less effective than PHT, the positive effect of folic acid on serum BDNF levels was not observed.	Folic Acid	94-104	brain-derived neurotrophic factor	Rattus norvegicus	114-118
26657220-4	2016	METHODS: LysLys(HYNIC)-Bombesin (1-14) was conjugated to folic acid and the product was purified by size-exclusion high-performance liquid chromatography.	Folic Acid	57-67	gastrin releasing peptide	Homo sapiens	23-31
26657220-10	2016	In-vitro and in-vivo results showed significant uptake of the radiopharmaceutical in T47D cells and tumours (5.43% ID/g), which was significantly inhibited by preincubation with cold folic acid or cold Bombesin.	Folic Acid	183-193	gastrin releasing peptide	Homo sapiens	202-210
26830229-1	2016	Dihydrofolate reductase (DHFR) is a critical enzyme in the folate metabolism pathway and also plays a role in regulating nitric oxide (NO) signaling in endothelial cells.	Folic Acid	7-13	dihydrofolate reductase	Mus musculus	25-29
26806866-2	2016	Variants in the methylenetetrahydrofolate reductase gene (MTHFR), a gene encoding a folate-dependent enzyme that is involved in homocysteine metabolism, have been reported to be associated with PD.	Folic Acid	35-41	methylenetetrahydrofolate reductase	Homo sapiens	58-63
26809007-12	2016	However, when liposomes were directly injected into the peritoneal cavity of mice with malignant ascites of J6456 HiFR lymphoma cells, the tumor cell levels of MLP were significantly greater with the folate-targeted liposomes.	Folic Acid	200-206	cysteine and glycine-rich protein 3	Mus musculus	160-163
25869180-9	2016	In women, rs10817542 (ZNF618) and rs719856 (CD2AP) had an interaction with beta-carotene and folate intake and rs5443 (GNB3) had an interaction with vitamin E intake on baPWV.	Folic Acid	93-99	zinc finger protein 618	Homo sapiens	22-28
26880641-18	2016	This can be a result of decreased LSD1 activity resulting from the decreased folate available to scavenge the formaldehyde produced at the active site caused by the folate deficiency.	Folic Acid	77-83	lysine demethylase 1A	Homo sapiens	34-38
26880641-18	2016	This can be a result of decreased LSD1 activity resulting from the decreased folate available to scavenge the formaldehyde produced at the active site caused by the folate deficiency.	Folic Acid	165-171	lysine demethylase 1A	Homo sapiens	34-38
26880641-19	2016	Because LSD1 can regulate gene expression this suggests that folate may play a more important role than simply serving as a carrier of one-carbon units and be a factor in other diseases associated with low folate.	Folic Acid	61-67	lysine demethylase 1A	Homo sapiens	8-12
26880641-19	2016	Because LSD1 can regulate gene expression this suggests that folate may play a more important role than simply serving as a carrier of one-carbon units and be a factor in other diseases associated with low folate.	Folic Acid	206-212	lysine demethylase 1A	Homo sapiens	8-12
26846716-0	2016	Folic acid reverses uric acid crystal-induced surface OAT1 internalization by inhibiting RhoA activity in uric acid nephropathy.	Folic Acid	0-10	solute carrier family 22 member 6	Rattus norvegicus	54-58
26846716-0	2016	Folic acid reverses uric acid crystal-induced surface OAT1 internalization by inhibiting RhoA activity in uric acid nephropathy.	Folic Acid	0-10	ras homolog family member A	Rattus norvegicus	89-93
26846716-7	2016	Finally, the results indicated that folic acid, a daily nutritional supplement, was capable of rescuing MSU-induced nephropathy and OAT1 internalization.	Folic Acid	36-46	solute carrier family 22 member 6	Rattus norvegicus	132-136
26846716-8	2016	These observations indicated that uric acid crystals were able to reduce the OAT1 membrane distribution through activating RhoA, and that folic acid was capable of preventing MSU-induced OAT1 relocation by inhibiting the RhoA signaling pathway.	Folic Acid	138-148	solute carrier family 22 member 6	Rattus norvegicus	187-191
26846716-8	2016	These observations indicated that uric acid crystals were able to reduce the OAT1 membrane distribution through activating RhoA, and that folic acid was capable of preventing MSU-induced OAT1 relocation by inhibiting the RhoA signaling pathway.	Folic Acid	138-148	ras homolog family member A	Rattus norvegicus	221-225
26218632-1	2016	BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) gene encodes an essential enzyme involving in folate metabolism.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	49-54
26218632-2	2016	Due to the role of folate in DNA integrity, polymorphisms of MTHFR are interesting targets for cancer risk studies.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	61-66
26833750-6	2016	MTHFR G1793A showed a statistically significant interaction between dietary folate intake and gastric cancer.	Folic Acid	76-82	methylenetetrahydrofolate reductase	Homo sapiens	0-5
26833750-7	2016	CONCLUSION: Our results suggest that MTR A2756G is significantly associated with gastric cancer risk, and that MTHFR G1793A statistically interacts with dietary folate intake.	Folic Acid	161-167	methylenetetrahydrofolate reductase	Homo sapiens	111-116
26939404-2	2016	Methylenetetrahydrofolate reductase (MTHFR) is a key regulatory enzyme involved in folate metabolism.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
26641134-5	2016	The obtained PEI-PCL-PEG-Fol exhibited less cytotoxicity in comparison with the corresponding ternary copolymer without folate (PEI-PCL-PEG) and with unmodified PEI25kDa.	Folic Acid	120-126	PHD finger protein 1	Homo sapiens	17-20
26722024-4	2016	TAS-102 is a newly-developed anti-folate drug containing the 5-FU analogue trifluridine (TFD) and tipiracil hydrochloride (TPI).	Folic Acid	34-40	THAS	Homo sapiens	0-3
26843177-1	2016	OBJECTIVES: Impairment of methylene tetrahydrofolate reductase (MTHFR), a key enzyme in the folate metabolism, results in an elevated plasma level of homocysteine, considered an independent risk factor for cardiovascular (CV) disease.	Folic Acid	46-52	methylenetetrahydrofolate reductase	Homo sapiens	64-69
26898294-6	2016	We report three patients with severe MTHFR deficiency (enzyme activity &lt;=1% of controls) who had undetectable levels of CSF 5-MTHF at diagnosis and while on treatment with either folic acid or calcium folinate.	Folic Acid	182-192	methylenetetrahydrofolate reductase	Homo sapiens	37-42
27738387-7	2016	We also observed that folic acid dose-dependently upregulated both SOCS1 and SOCS3 expression in BV-2 cells, leading to an increased expression of the anti-inflammatory cytokine IL-10.	Folic Acid	22-32	suppressor of cytokine signaling 1	Mus musculus	67-72
27738387-8	2016	Finally, p-IkappaBalpha, which indirectly reflects NF-kappaB complex activation, and JNK phosphorylation resulted dose-dependently downregulated by folic acid pretreatment of LPS-activated cells, whereas p38 MAPK phosphorylation resulted significantly upregulated by folic acid treatment.	Folic Acid	148-158	mitogen-activated protein kinase 8	Mus musculus	85-88
27738387-8	2016	Finally, p-IkappaBalpha, which indirectly reflects NF-kappaB complex activation, and JNK phosphorylation resulted dose-dependently downregulated by folic acid pretreatment of LPS-activated cells, whereas p38 MAPK phosphorylation resulted significantly upregulated by folic acid treatment.	Folic Acid	267-277	mitogen-activated protein kinase 8	Mus musculus	85-88
27905385-1	2016	AIM: To study a role of MTHFR mutations and their associations with the disturbances of basic parameters of the folate cycle in the development of ischemic stroke (IS).	Folic Acid	112-118	methylenetetrahydrofolate reductase	Homo sapiens	24-29
26595280-3	2015	The methionine synthase (MTR) gene plays key role in maintaining adequate intracellular folate, methionine and normal homocysteine concentrations and, its polymorphism have been associated with the risk of retinoblastoma and other neoplasms.	Folic Acid	88-94	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	4-23
26095803-1	2015	Methylenetetrahydrofolate reductase (MTHFR) reduces 5",10"-methylenetetrahydrofolate to 5"-methyltetrahydrofolate, and is involved in remethylation of homocysteine to methionine, two important reactions involved in folate metabolism and methylation pathways.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
26269367-10	2015	Although 3 fetal MTHFR and DHFR genetic variants had no effect, the fetal MTHFR 677TT genotype was associated with significantly lower cord serum (P = 0.03) and higher cord RBC (P = 0.02) folate concentrations than those of the wild type.	Folic Acid	188-194	methylenetetrahydrofolate reductase	Homo sapiens	74-79
26677583-8	2015	Women carriers of the mutated variants of both, 677C&gt;T and 1298A&gt;C polymorphisms of the MTHFR gene should receive special perinatal care in order to prevent fetal defects and thrombosis-related complications during pregnancy It is vital to emphasize the significance of proper education of folate supplementation, especially in pregnant patients and women of reproductive age.	Folic Acid	296-302	methylenetetrahydrofolate reductase	Homo sapiens	94-99
25801246-0	2015	Breast cancer risk associated with gene expression and genotype polymorphisms of the folate-metabolizing MTHFR gene: a case-control study in a high altitude Ecuadorian mestizo population.	Folic Acid	85-91	methylenetetrahydrofolate reductase	Homo sapiens	105-110
25801246-3	2015	The single nucleotide polymorphisms, MTHFR C677T, A1298C, MTR A2756G, and MTRR A66G, alter plasmatic folate and homocysteine concentrations, causing problems during the repairment, synthesis, and methylation of the genetic material.	Folic Acid	101-107	methylenetetrahydrofolate reductase	Homo sapiens	37-42
26214484-3	2015	Methylation levels of the MTHFR gene in placentas in two sets of gravidas were detected by methylation-specific polymerase chain reaction, plasma homocysteine levels were detected by enzyme-linked immunosorbent assay, and folic acid and vitamin B12 levels were detected by electrochemiluminescence.	Folic Acid	222-232	methylenetetrahydrofolate reductase	Homo sapiens	26-31
25888801-3	2015	We have successfully developed nanosized folate-conjugated PEGylated PLGA nanoparticles (SRF/FA-PEG-PLGA NP) with both anticancer and magnetic resonance property.	Folic Acid	41-47	serum response factor	Homo sapiens	89-92
26181632-0	2015	Antiinflammatory Activity of a Novel Folic Acid Targeted Conjugate of the mTOR Inhibitor Everolimus.	Folic Acid	37-47	mechanistic target of rapamycin kinase	Rattus norvegicus	74-78
26181632-13	2015	Folate-targeted mTOR inhibition may be an effective way of suppressing activated macrophages in sites of inflammation, especially in nutrient-deprived conditions, such as in the arthritic joints.	Folic Acid	0-6	mechanistic target of rapamycin kinase	Rattus norvegicus	16-20
26131679-0	2015	A Synthetic Bandwidth Method for High-Resolution SAR Based on PGA in the Range Dimension.	Folic Acid	62-65	sarcosine dehydrogenase	Homo sapiens	49-52
26131679-7	2015	It considers two main errors of the multi-sub-band SAR system and compensates them by a two-order PGA (phase gradient auto-focus)-based method, named TRPGA.	Folic Acid	98-101	sarcosine dehydrogenase	Homo sapiens	51-54
25887077-1	2015	BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is an essential enzyme in the metabolism of folate.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	49-54
25536437-10	2015	CONCLUSION: Our results suggest that mother and child RFC-1 G80A genotypes play a role on the risk of neuroblastoma and nephroblastoma since this polymorphism may impair the intracellular levels of folate, through carrying fewer folate molecules to the cell interior, and thus, the intracellular concentration is not enough to maintain regular DNA synthesis and methylation pathways.	Folic Acid	198-204	replication factor C subunit 1	Homo sapiens	54-59
25536437-10	2015	CONCLUSION: Our results suggest that mother and child RFC-1 G80A genotypes play a role on the risk of neuroblastoma and nephroblastoma since this polymorphism may impair the intracellular levels of folate, through carrying fewer folate molecules to the cell interior, and thus, the intracellular concentration is not enough to maintain regular DNA synthesis and methylation pathways.	Folic Acid	229-235	replication factor C subunit 1	Homo sapiens	54-59
25318348-2	2015	Single-nucleotide polymorphisms (SNPs) of the folate-metabolising enzyme methylenetetrahydrofolate-reductase (MTHFR) may modify the association between folate intake and BC and influence plasma folate concentration.	Folic Acid	46-52	methylenetetrahydrofolate reductase	Homo sapiens	73-108
25318348-2	2015	Single-nucleotide polymorphisms (SNPs) of the folate-metabolising enzyme methylenetetrahydrofolate-reductase (MTHFR) may modify the association between folate intake and BC and influence plasma folate concentration.	Folic Acid	46-52	methylenetetrahydrofolate reductase	Homo sapiens	110-115
25318348-2	2015	Single-nucleotide polymorphisms (SNPs) of the folate-metabolising enzyme methylenetetrahydrofolate-reductase (MTHFR) may modify the association between folate intake and BC and influence plasma folate concentration.	Folic Acid	92-98	methylenetetrahydrofolate reductase	Homo sapiens	110-115
25318348-2	2015	Single-nucleotide polymorphisms (SNPs) of the folate-metabolising enzyme methylenetetrahydrofolate-reductase (MTHFR) may modify the association between folate intake and BC and influence plasma folate concentration.	Folic Acid	92-98	methylenetetrahydrofolate reductase	Homo sapiens	110-115
25283235-1	2015	OBJECTIVE: To study folic acid intake, folate status and pregnancy outcome after infertility treatment in women with different infertility diagnoses in relation to methylenetetrahydrofolate reductase (MTHFR) 677C&gt;T, 1298A&gt;C and 1793G&gt;A polymorphisms.	Folic Acid	20-30	methylenetetrahydrofolate reductase	Homo sapiens	164-199
26745044-2	2015	Folate deficiency and methylenetetrahydrofolate reductase (MTHFR) as an important enzyme of folate and methionine metabolism are considered crucial for DNA synthesis and methylation.	Folic Acid	41-47	methylenetetrahydrofolate reductase	Homo sapiens	59-64
26107198-1	2015	BACKGROUND: The MTHFR C677T polymorphism is a genetic alteration affecting an enzyme involved in folate metabolism, but its relationship to host susceptibility to prostate cancer remains uncertain.	Folic Acid	97-103	methylenetetrahydrofolate reductase	Homo sapiens	16-21
26929921-3	2015	This study aimed to evaluate the effect of high dose folic acid (FA) on serum Hcy and Lp(a) concentrations with respect to methylenetetrahydrofolate reductase (MTHFR) polymorphisms 677C T during pregnancy.	Folic Acid	53-63	methylenetetrahydrofolate reductase	Homo sapiens	123-158
25629224-8	2015	DUSP4 and MAPK8 interacted with calories to alter breast cancer risk; MAPK1 interacted with DOBS, dietary fiber, folate, and BMI; MAP3K2 interacted with dietary fat; and MAPK14 interacted with dietary folate and BMI.	Folic Acid	201-207	dual specificity phosphatase 4	Homo sapiens	0-5
25549641-1	2014	OBJECTIVE: To explore the association between serum concentrations of folic acid and homocysteine (HCY), 5, 10-methylenetetrahydrofolate reductase (MTHFR) C667T polymorphism and schizophrenia.	Folic Acid	70-80	methylenetetrahydrofolate reductase	Homo sapiens	108-146
25549641-1	2014	OBJECTIVE: To explore the association between serum concentrations of folic acid and homocysteine (HCY), 5, 10-methylenetetrahydrofolate reductase (MTHFR) C667T polymorphism and schizophrenia.	Folic Acid	70-80	methylenetetrahydrofolate reductase	Homo sapiens	148-153
32098547-1	2021	Background: The methylene tetrahydrofolate reductase (MTHFR) is a folate-dependent enzyme which catalyzes the conversion of homocysteine to methionine.	Folic Acid	36-42	methylenetetrahydrofolate reductase	Homo sapiens	54-59
33160997-10	2021	Senescence-associated beta-galactosidase activity staining revealed that folic acid attenuated cardiac senescence by down-regulating p53/p21/p16 levels.	Folic Acid	73-83	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	137-140
33126053-0	2021	Targeting feed-forward signaling of TGFbeta/NOX4/DHFR/eNOS uncoupling/TGFbeta axis with anti-TGFbeta and folic acid attenuates formation of aortic aneurysms: Novel mechanisms and therapeutics.	Folic Acid	105-115	dihydrofolate reductase	Mus musculus	49-53
33126053-4	2021	Intriguingly, oral administration with folic acid (FA) to recouple eNOS markedly alleviated expansion of aortic roots and abdominal aortas in Fbn1C1039G/+ mice, which was attributed to substantially upregulated DHFR expression and activity in the endothelium to restore tissue and circulating levels of H4B.	Folic Acid	39-49	fibrillin 1	Mus musculus	142-146
33126053-4	2021	Intriguingly, oral administration with folic acid (FA) to recouple eNOS markedly alleviated expansion of aortic roots and abdominal aortas in Fbn1C1039G/+ mice, which was attributed to substantially upregulated DHFR expression and activity in the endothelium to restore tissue and circulating levels of H4B.	Folic Acid	39-49	dihydrofolate reductase	Mus musculus	211-215
33371087-0	2020	The recent effects of small dose of folic acid on lipoprotein-associated phospholipase A2 and systolic blood pressure variability in coronary heart disease patients with hyperhomocysteinemia: A single-center prospective cohort study.	Folic Acid	36-46	phospholipase A2 group VII	Homo sapiens	50-89
33371087-1	2020	ABSTRACT: To Investigate the recent effects of small dose of folic acid on lipoprotein-associated phospholipase A2 (LP-PLA2) and systolic blood pressure variability in coronary heart disease (CHD) patients with hyperhomocysteinemia.In this prospective cohort study, a total of 167 CHD patients with hyperhomocysteinemia were consecutively enrolled, and they were divided into Group A (without folic acid intervention, n = 99), Group B (with 0.4 mg of folic acid intervention, n = 34), Group C (0.8 mg of folic acid intervention, n = 34).	Folic Acid	61-71	phospholipase A2 group VII	Homo sapiens	75-114
33371087-1	2020	ABSTRACT: To Investigate the recent effects of small dose of folic acid on lipoprotein-associated phospholipase A2 (LP-PLA2) and systolic blood pressure variability in coronary heart disease (CHD) patients with hyperhomocysteinemia.In this prospective cohort study, a total of 167 CHD patients with hyperhomocysteinemia were consecutively enrolled, and they were divided into Group A (without folic acid intervention, n = 99), Group B (with 0.4 mg of folic acid intervention, n = 34), Group C (0.8 mg of folic acid intervention, n = 34).	Folic Acid	61-71	phospholipase A2 group VII	Homo sapiens	116-123
33426516-2	2021	Folate processing (Methylenetetrahydrofolate reductase, MTHFR) gene abnormalities are common in women with epilepsy and depression.	Folic Acid	0-6	methylenetetrahydrofolate reductase	Homo sapiens	19-54
33426516-2	2021	Folate processing (Methylenetetrahydrofolate reductase, MTHFR) gene abnormalities are common in women with epilepsy and depression.	Folic Acid	0-6	methylenetetrahydrofolate reductase	Homo sapiens	56-61
33315905-3	2020	The MTHFR C677T variant influences folate metabolism and has been implicated in depression during pregnancy.	Folic Acid	35-41	methylenetetrahydrofolate reductase	Homo sapiens	4-9
33315905-5	2020	HYPOTHESIS: In the first three months postpartum, folate will moderate a relationship between MTHFR genotype and depression, with TT homozygous women having more symptoms than CC homozygous women.	Folic Acid	50-56	methylenetetrahydrofolate reductase	Homo sapiens	94-99
33315905-10	2020	DISCUSSION: These data suggest that perhaps there is a relationship between MTHFR C677T, folate level and some symptoms of postpartum psychopathology.	Folic Acid	89-95	methylenetetrahydrofolate reductase	Homo sapiens	76-81
33317014-2	2020	Maternal nutrient levels during pregnancy affect development, and methylene tetrahydrofolate reductase (MTHFR) is important for processing the nutrient folate.	Folic Acid	86-92	methylenetetrahydrofolate reductase	Homo sapiens	104-109
33372619-0	2020	MicroRNA-302a is involved in folate deficiency-induced apoptosis through the AKT-FOXO1-BIM pathway in mouse embryonic stem cells.	Folic Acid	29-35	BCL2-like 11 (apoptosis facilitator)	Mus musculus	87-90
33372619-11	2020	Real-time quantitative PCR and immunoblotting showed that in folate-free conditions, miR-302a and AKT were down regulated, while FOXO1 and Bim were up-regulated significantly.	Folic Acid	61-67	BCL2-like 11 (apoptosis facilitator)	Mus musculus	139-142
33372619-12	2020	Additionally, treatment with LY294002 inhibitor revealed the involvement of the Akt/FOXO1/Bim signaling pathway in folate deficiency-induced apoptosis, rather than the ERK pathway.	Folic Acid	115-121	BCL2-like 11 (apoptosis facilitator)	Mus musculus	90-93
33372619-14	2020	CONCLUSION: The involvement of miR-302a in folate deficiency-induced apoptosis through the AKT-FOXO1-BIM pathway in mESCs is a unique demonstration of the regulation mechanism of nutrient expression in embryonic development.	Folic Acid	43-49	BCL2-like 11 (apoptosis facilitator)	Mus musculus	101-104
33164984-3	2020	The folate pathway genes SLC19A1, ABCC1, ABCC4, FPGS, and MTHFD1 significantly influenced intracellular MTXPG levels (P = 2.9 x 10-3 to 3.7 x 10-8).	Folic Acid	4-10	ATP binding cassette subfamily C member 4	Homo sapiens	41-46
32521439-1	2020	The aim of this study was to determine how folate and iron deficiency, and the subsequent supplementation of rats" diet with these nutrients, affects Slc19a1and Tfr2 gene expression and the metabolism of folate and iron.	Folic Acid	43-49	transferrin receptor 2	Rattus norvegicus	161-165
10955484-2	2000	Chromosome analysis showed the expression of the rare folate-sensitive fragile site FRA12A at 12q13 in 8/20 (40%) of blood lymphocytes cultured in folate-deficient medium in the presence of trimethoprim.	Folic Acid	147-153	fragile site, folic acid type, rare, fra(12)(q13.1)	Homo sapiens	84-90
32188521-13	2020	In the subgroup analysis, MTHFR 677C>T modified the effect of folate status on homocysteine concentration.	Folic Acid	62-68	methylenetetrahydrofolate reductase	Homo sapiens	26-31
10820175-10	2000	After completion of the 4-wk treatment period with 30 or 60 mg of folic acid per day, there was a marked rebound of total homocysteine plasma levels at the end of the follow-up in patients with the MTHFR 677TT genotype, which even exceeded baseline values in several patients (P = 0.0001).	Folic Acid	66-76	methylenetetrahydrofolate reductase	Homo sapiens	198-203
33717913-3	2021	Folate metabolism might be affected by Methylene Tetrahydrofolate Reductase (MTHFR) gene polymorphism.	Folic Acid	0-6	methylenetetrahydrofolate reductase	Homo sapiens	39-75
33717913-3	2021	Folate metabolism might be affected by Methylene Tetrahydrofolate Reductase (MTHFR) gene polymorphism.	Folic Acid	0-6	methylenetetrahydrofolate reductase	Homo sapiens	77-82
10791559-1	2000	The enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR) is involved in folate metabolism.	Folic Acid	35-41	methylenetetrahydrofolate reductase	Homo sapiens	53-58
32915913-10	2020	Genes, including Ttc38, Sema3A, Insl3, Dll1, Msh4 and Snai1, were the novel factors that may be associated with the development of the kidneys and related to folic acid treatment.	Folic Acid	158-168	snail family zinc finger 1	Mus musculus	54-59
10928104-13	2000	Since MTHFR polymorphism and pregnancy increases folate requirements and can impair folate status, this association could reflect an inadequate response of mutant MTHFR genotype carriers to the increased demand for folate imposed by pregnancy.	Folic Acid	49-55	methylenetetrahydrofolate reductase	Homo sapiens	6-11
32880830-0	2020	Detection and characterisation of novel alternative splicing variants of the mitochondrial folate enzyme MTHFD2.	Folic Acid	91-97	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	Homo sapiens	105-111
32880830-2	2020	The mitochondrial folate metabolism enzyme methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) has been receiving attention in recent years as one of the most frequently upregulated metabolic enzymes across multiple tumour types.	Folic Acid	18-24	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	Homo sapiens	43-84
32880830-2	2020	The mitochondrial folate metabolism enzyme methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) has been receiving attention in recent years as one of the most frequently upregulated metabolic enzymes across multiple tumour types.	Folic Acid	18-24	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	Homo sapiens	86-92
10928104-13	2000	Since MTHFR polymorphism and pregnancy increases folate requirements and can impair folate status, this association could reflect an inadequate response of mutant MTHFR genotype carriers to the increased demand for folate imposed by pregnancy.	Folic Acid	84-90	methylenetetrahydrofolate reductase	Homo sapiens	6-11
10928104-13	2000	Since MTHFR polymorphism and pregnancy increases folate requirements and can impair folate status, this association could reflect an inadequate response of mutant MTHFR genotype carriers to the increased demand for folate imposed by pregnancy.	Folic Acid	84-90	methylenetetrahydrofolate reductase	Homo sapiens	6-11
10830195-1	2000	The aim of this study was to investigate a possible association among the thermolabile polymorphism, nucleotide 677 cytosine to thymidine point mutation (677 C--&gt;T) of the methylenetetrahydrofolate reductase (MTHFR) gene, hyperhomocysteinemia, serum folate, vitamins B12 and B6, and stroke in children.	Folic Acid	194-200	methylenetetrahydrofolate reductase	Homo sapiens	212-217
32649885-4	2020	During progression and metastasis, tumor cells adapt to oxidative stress by increasing NADPH in various ways, including activation of AMPK, the PPP, and reductive glutamine and folate metabolism.	Folic Acid	177-183	2,4-dienoyl-CoA reductase 1	Homo sapiens	87-92
32811824-1	2020	The folate-coupled metabolic enzyme MTHFD2 (the mitochondrial methylenetetrahydrofolate dehydrogenase/cyclohydrolase) confers redox homeostasis and drives cancer cell proliferation and migration.	Folic Acid	4-10	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	Homo sapiens	36-42
10780318-9	2000	In a generalized linear model, 44% of the variation in tHcy levels was explained by folate and vitamin B12 levels, the MTHFR genotype, gender, and by the interaction of the MTHFR genotype with folate (p &lt; or =0.028); the interactions of vitamin B12 with the MTHFR genotype, gender and patient/control status also significantly contributed to the variation in tHcy levels (p &lt; or =0.028).	Folic Acid	193-199	methylenetetrahydrofolate reductase	Homo sapiens	173-178
32612532-4	2020	Folic acid and arginine-glycine-aspartate (Arg-Gly-Asp, RGD) tripeptide sequence have a high affinity for folate receptor and integrin alpha v beta 3, respectively.	Folic Acid	0-10	integrin subunit alpha V	Homo sapiens	126-149
32404292-11	2020	T/T genotype of MTHFR modifies the relationship between folate and homocysteine.	Folic Acid	56-62	methylenetetrahydrofolate reductase	Homo sapiens	16-21
10780318-9	2000	In a generalized linear model, 44% of the variation in tHcy levels was explained by folate and vitamin B12 levels, the MTHFR genotype, gender, and by the interaction of the MTHFR genotype with folate (p &lt; or =0.028); the interactions of vitamin B12 with the MTHFR genotype, gender and patient/control status also significantly contributed to the variation in tHcy levels (p &lt; or =0.028).	Folic Acid	193-199	methylenetetrahydrofolate reductase	Homo sapiens	173-178
10780318-11	2000	Subjects carrying the MTHFR 677TT genotype have higher folate and vitamin B12 requirements irrespective of the A2756G polymorphism of the MS gene.	Folic Acid	55-61	methylenetetrahydrofolate reductase	Homo sapiens	22-27
10884945-4	2000	The relationship between the methylenetetrahydrofolate reductase gene and dietary folate is an example of a diet-gene interaction that involves a polymorphism in a vitamin metabolism gene, and the presence of the variant appears to influence both risk for cancer and folate requirements.	Folic Acid	82-88	methylenetetrahydrofolate reductase	Homo sapiens	29-64
32318793-3	2020	The aim of this study was to explore whether polymorphisms of MTHFR and MTR influence arsenic methylation capacity and plasma folate and vitamin B12 levels and if these influences cause developmental delay in preschool children.	Folic Acid	126-132	methylenetetrahydrofolate reductase	Homo sapiens	62-67
11277368-8	2000	The lowering action of carbamazepine treatment on folate levels seems to be associated with hyperhomocysteinaemia, which seems to be related to the homozygous condition for the MTHFR 677C--&gt;T mutation.	Folic Acid	50-56	methylenetetrahydrofolate reductase	Homo sapiens	177-182
32318793-9	2020	Subjects with the MTHFR C677T C/C genotype had significantly lower plasma folate and vitamin B12 levels than those with the MTHFR C677T C/T and T/T genotype.	Folic Acid	74-80	methylenetetrahydrofolate reductase	Homo sapiens	18-23
32145458-2	2020	Two intracellular enzymes, methionine synthase and methylmalonyl-CoA mutase, are folate and/or cobalamin-dependent, respectively.	Folic Acid	81-87	5-methyltetrahydrofolate-homocysteine methyltransferase	Sus scrofa	27-46
10720211-1	2000	Methylenetetrahydrofolate reductase (MTHFR) plays a central role in the folate cycle and contributes to the metabolism of the amino acid homocysteine.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
32142918-8	2020	Similar to its family member SHMT2, SHMT1 plays a crucial role in folate-dependent serine/glycine inter-conversion in one-carbon metabolism.	Folic Acid	66-72	serine hydroxymethyltransferase 2	Homo sapiens	29-34
32476787-8	2020	Furthermore, peroxisome proliferator-activated receptor alpha (PPARalpha) and silence information regulation factor 1 (SIRT1) were restored by folic acid in HFD-fed rats and palmitic acid-exposed Huh7 cell line.	Folic Acid	143-153	MIR7-3 host gene	Homo sapiens	196-200
32476787-9	2020	The restoration of PPARalpha by folic acid was blocked after transfection with SIRT1 siRNA in the Huh7 cell line.	Folic Acid	32-42	sirtuin 1	Homo sapiens	79-84
32476787-9	2020	The restoration of PPARalpha by folic acid was blocked after transfection with SIRT1 siRNA in the Huh7 cell line.	Folic Acid	32-42	MIR7-3 host gene	Homo sapiens	98-102
11040276-9	2000	These findings have been bolstered by an association between incidence of colon cancer and a polymorphism in the gene for methylenetetrahydrofolate reductase, an enzyme involved in folic acid metabolism.	Folic Acid	181-191	methylenetetrahydrofolate reductase	Homo sapiens	122-157
11011843-4	2000	The best example of this concept is a missense mutation (alanine to valine) at base pair (bp) 677 of methylenetetrahydrofolate reductase (MTHFR), the enzyme that provides the folate derivative for conversion of homocysteine to methionine.	Folic Acid	120-126	methylenetetrahydrofolate reductase	Homo sapiens	138-143
32440179-1	2020	Purpose: Red blood cell (RBC) folate indicates long-term folate intake, and methylenetetrahydrofolate reductase (MTHFR) gene is the main gene affecting folate status.	Folic Acid	57-63	methylenetetrahydrofolate reductase	Homo sapiens	113-118
32440179-1	2020	Purpose: Red blood cell (RBC) folate indicates long-term folate intake, and methylenetetrahydrofolate reductase (MTHFR) gene is the main gene affecting folate status.	Folic Acid	57-63	methylenetetrahydrofolate reductase	Homo sapiens	113-118
32440179-11	2020	Conclusion: Higher RBC folate, partly caused by MTHFR 677C T, may be associated with increased GDM risk, even in early pregnancy.	Folic Acid	23-29	methylenetetrahydrofolate reductase	Homo sapiens	48-53
32440179-12	2020	Assessing RBC folate status and appropriately supplementing folate during early pregnancy, particularly for patients with MTHFR 677C T, may prevent GDM.	Folic Acid	60-66	methylenetetrahydrofolate reductase	Homo sapiens	122-127
11860891-11	2000	Higher level of folate in the body can interfere the relationship between plasma tHcy and activity of MTHFR.	Folic Acid	16-22	methylenetetrahydrofolate reductase	Homo sapiens	102-107
31332704-1	2020	PURPOSE: KRAS mutation has been associated with enhanced dependency on the folate metabolism in preclinical studies.	Folic Acid	75-81	KRAS proto-oncogene, GTPase	Homo sapiens	9-13
32266834-5	2020	Results: The study demonstrates that the genetic variants in folate cycle and methionine cycle genes such as MTHFR, MTRR, MTR, BHMT and DNMT1 are associated with the risk of aneurysm.	Folic Acid	61-67	methylenetetrahydrofolate reductase	Homo sapiens	109-114
32266834-5	2020	Results: The study demonstrates that the genetic variants in folate cycle and methionine cycle genes such as MTHFR, MTRR, MTR, BHMT and DNMT1 are associated with the risk of aneurysm.	Folic Acid	61-67	DNA methyltransferase 1	Homo sapiens	136-141
10593891-1	1999	Methylenetetrahydrofolate reductase (MTHFR) is the least understood enzyme of folate-mediated one-carbon metabolism in plants.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
32013623-1	2020	Purpose: To assess the associations between preeclampsia, methylenetetrahydrofolate reductase (MTHFR) C677T, and reduced folate carrier-1 (RFC-1) G80A gene polymorphism in Sudanese women.Methods: A matched (for age and parity) case-control study was conducted in a tertiary hospital (Saad Abualila) in Khartoum, Sudan during February to September 2018.	Folic Acid	77-83	methylenetetrahydrofolate reductase	Homo sapiens	95-100
10536004-10	1999	Individuals with the MTHFR 677TT, 1298AC, and 1298CC genotypes have a decreased risk of adult ALL, but not acute myeloid leukemia, which suggests that folate inadequacy may play a key role in the development of ALL.	Folic Acid	151-157	methylenetetrahydrofolate reductase	Homo sapiens	21-26
32340630-1	2020	BACKGROUND: The methylenetetrahydrofolate reductase (MTHFR) rs1801131 A/C variant results in a decrease in MTHFR enzymatic activity, which may play an important role in folate metabolism and is also an important source of DNA methylation and DNA synthesis.	Folic Acid	35-41	methylenetetrahydrofolate reductase	Homo sapiens	53-58
32340630-1	2020	BACKGROUND: The methylenetetrahydrofolate reductase (MTHFR) rs1801131 A/C variant results in a decrease in MTHFR enzymatic activity, which may play an important role in folate metabolism and is also an important source of DNA methylation and DNA synthesis.	Folic Acid	35-41	methylenetetrahydrofolate reductase	Homo sapiens	107-112
32295203-0	2020	RX-3117 (Fluorocyclopentenyl-Cytosine)-Mediated Down-Regulation of DNA Methyltransferase 1 Leads to Protein Expression of Tumor-Suppressor Genes and Increased Functionality of the Proton-Coupled Folate Carrier.	Folic Acid	195-201	DNA methyltransferase 1	Homo sapiens	67-90
10537295-7	1999	A higher risk of Ki-ras mutations was associated with increasing age and a lower intake of total folate.	Folic Acid	97-103	KRAS proto-oncogene, GTPase	Homo sapiens	17-23
10537295-9	1999	Compared with individuals in the lower tertile of total folate, those in the upper tertile had an approximately 50% lower risk of having Ki-ras mutation-positive adenomas (OR = 0.52; 95% CI = 0.30-0.88; P for trend = 0.02).	Folic Acid	56-62	KRAS proto-oncogene, GTPase	Homo sapiens	137-143
10508931-4	1999	The OAT-K1-mediated methotrexate transport was significantly inhibited in the presence of several organic anions such as folate and sulfobromophthalein.	Folic Acid	121-127	solute carrier organic anion transporter family member 1A3	Rattus norvegicus	4-10
32036390-3	2020	Here, we revealed for the first time that RIG-I was induced in unilateral ureteral obstruction (UUO) and folic acid (FA) renal fibrosis models and moderate-degree renal fibrosis patients.	Folic Acid	105-115	DExD/H-box helicase 58	Homo sapiens	42-47
10910677-6	1999	Presence of the MTHFR 677 C--&gt;T mutation increases the requirements for folic acid, especially at the time of rapid foetal growth.	Folic Acid	75-85	methylenetetrahydrofolate reductase	Homo sapiens	16-21
32119787-1	2020	Purpose: The methylene tetrahydrofolate reductase (MTHFR) C677T, MTHFR A1298C, and the methionine synthase reductase (MTRR) A66G polymorphisms are the three most common folate metabolism-related loci in the Chinese population.	Folic Acid	33-39	methylenetetrahydrofolate reductase	Homo sapiens	51-56
31994802-10	2020	The transcriptomic analysis revealed that folic acid treatment regulated many key metabolic-related genes (DGAT2, ALOX5, LAP3, GPAT3, GGH, ALDOA, TKT) and pathways (glycolysis, folate biosynthesis, glutathione metabolism, etc.)	Folic Acid	42-52	gamma-glutamyl hydrolase	Bos taurus	134-137
10744125-6	1999	The associations between dietary intakes of folate, vitamin B12, vitamin B6, or methionine and risk of adenomas showed consistent patterns dependent upon MTHFR genotype.	Folic Acid	44-50	methylenetetrahydrofolate reductase	Homo sapiens	154-159
31734877-1	2020	OBJECTIVE: Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme involved in folate metabolism.	Folic Acid	30-36	methylenetetrahydrofolate reductase	Homo sapiens	48-53
10744125-11	1999	Low intakes of folate, vitamin B12, and vitamin B6 increase risk among those (particularly the elderly) with the MTHFR TT genotype.	Folic Acid	15-21	methylenetetrahydrofolate reductase	Homo sapiens	113-118
10397696-12	1999	We conclude that in patients with VTE who do not have coexisting prothrombotic defects, hyperhomocystinemia increases the risk of developing idiopathic and venous thrombosis; the homozygous condition for the MTHFR mutation confers a moderate risk but, together with low folate levels, it is the main determinant of mild hyperhomocystinemia in normal and thromboembolic populations.	Folic Acid	270-276	methylenetetrahydrofolate reductase	Homo sapiens	208-213
32088725-2	2020	Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is a key enzyme involved in folate metabolism and is closely related to the proliferation in many cancers.	Folic Acid	19-25	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	Homo sapiens	43-49
29848222-5	2020	Increased body weight and food intake at 9-weeks post-weaning were accompanied by a reduced activation of POMC neurons in the arcuate nucleus (ARC).Conclusion: Gestational folic acid content modulates expression of mature hypothalamic NPY-positive neurons at birth and activation of POMC-positive neurons at 9-weeks post-weaning in the ARC of male Wistar rat offspring which may contribute to higher body weight and food intake later in life.	Folic Acid	172-182	proopiomelanocortin	Rattus norvegicus	106-110
10359544-10	1999	There is also evidence that some metabolic pathways, e.g., those involving folate and heterocyclic amines, may be modified by polymorphisms in relevant genes, e.g., MTHFR (methylenetetrahydrofolate reductase) and NAT1 (N-acetyltransferase 1) and NAT2.	Folic Acid	75-81	probable methylenetetrahydrofolate reductase	Nicotiana tabacum	165-170
29848222-5	2020	Increased body weight and food intake at 9-weeks post-weaning were accompanied by a reduced activation of POMC neurons in the arcuate nucleus (ARC).Conclusion: Gestational folic acid content modulates expression of mature hypothalamic NPY-positive neurons at birth and activation of POMC-positive neurons at 9-weeks post-weaning in the ARC of male Wistar rat offspring which may contribute to higher body weight and food intake later in life.	Folic Acid	172-182	proopiomelanocortin	Rattus norvegicus	283-287
31691569-0	2019	Folic acid-deficient diet during gestation and post-weaning alters Pomc gene and protein expression in rat offspring.	Folic Acid	0-10	proopiomelanocortin	Rattus norvegicus	67-71
31691569-3	2019	We hypothesize that offspring exposed to less folic acid will express higher levels of Pomc (proopiomelanocortin) gene mRNA.	Folic Acid	46-56	proopiomelanocortin	Rattus norvegicus	87-91
31920364-3	2019	The aim of the study was to investigate the effect of folate metabolizing genes (MTHFR and DHFR) polymorphisms on different parameters of complete blood count in patients who were treated with carbamazepine and valproic acid.	Folic Acid	54-60	methylenetetrahydrofolate reductase	Homo sapiens	81-86
10359544-10	1999	There is also evidence that some metabolic pathways, e.g., those involving folate and heterocyclic amines, may be modified by polymorphisms in relevant genes, e.g., MTHFR (methylenetetrahydrofolate reductase) and NAT1 (N-acetyltransferase 1) and NAT2.	Folic Acid	75-81	probable methylenetetrahydrofolate reductase	Nicotiana tabacum	172-207
10385141-8	1999	Although associations were generally weak, these findings suggest that those with differing MTHFR genotypes may have different susceptibilities to colon cancer, based on dietary consumption of folate, vitamin B6, and vitamin B12.	Folic Acid	193-199	methylenetetrahydrofolate reductase	Homo sapiens	92-97
31763810-2	2019	Here, we developed CD44 and folate receptor (FR) dually targeted nanoparticulate doxorubicin (HA/FA-NP-DOX) based on a direct conjugate of two purely natural ligands, hyaluronic acid and folic acid (FA), for safe, highly specific and potent treatment of ovarian tumor in vivo.	Folic Acid	187-197	CD44 molecule (Indian blood group)	Homo sapiens	19-23
31672625-6	2019	Furthermore, tumor growth was significantly inhibited by folate-targeted NPs loaded with the low-dose DOX/miR-200c combination, but not by treatments with free DOX, miR-NPs or DOX-NPs.	Folic Acid	57-63	membrane associated ring-CH-type finger 8	Homo sapiens	106-109
10323785-7	1999	An interaction was found between MTHFR TT genotype and serum folate levels for both fasting and post-methionine tHcy, ie, for a given decrease in serum folate, homocysteine levels increased more in subjects with the TT genotype than in those with the CC genotype.	Folic Acid	61-67	methylenetetrahydrofolate reductase	Homo sapiens	33-38
31790421-8	2019	RESULTS: In CHOW-fed mice, AAV8.Ucn2 gene transfer (vs. saline) altered the metabolites in glycolysis, pentose phosphate, glycogen synthesis, glycogenolysis, and choline-folate-methionine signaling pathways.	Folic Acid	170-176	urocortin 2	Mus musculus	32-36
31601260-0	2019	Dietary intakes and biomarker patterns of folate, vitamin B6, and vitamin B12 can be associated with cognitive impairment by hypermethylation of redox-related genes NUDT15 and TXNRD1.	Folic Acid	42-48	thioredoxin reductase 1	Homo sapiens	176-182
10323785-7	1999	An interaction was found between MTHFR TT genotype and serum folate levels for both fasting and post-methionine tHcy, ie, for a given decrease in serum folate, homocysteine levels increased more in subjects with the TT genotype than in those with the CC genotype.	Folic Acid	152-158	methylenetetrahydrofolate reductase	Homo sapiens	33-38
31401974-3	2019	MTHFR and several vitamins (as cofactors) are crucial for remethylation of homocysteine via folate and homocysteine metabolism.	Folic Acid	92-98	methylenetetrahydrofolate reductase	Homo sapiens	0-5
10323785-11	1999	We also found evidence, in patients with premature vascular disease but not in their healthy siblings, for a factor that increases tHcy levels but weakens the normal inverse relation between folate and tHcy and amplifies the effect of the MTHFR genotype.	Folic Acid	191-197	methylenetetrahydrofolate reductase	Homo sapiens	239-244
10090889-8	1999	These results favor a biological model of MTHFR-related NTD pathogenesis in which suboptimal maternal folate status imposes biochemical stress on the developing embryo, a stress it is ill-equipped to tolerate if it has a TT genotype.	Folic Acid	102-108	methylenetetrahydrofolate reductase	Homo sapiens	42-47
10101033-4	1999	When expressed in Xenopus oocytes, OAT-K2 stimulated the uptake of hydrophobic organic anions, such as taurocholate, methotrexate, folate, and prostaglandin E2, although its homolog OAT-K1 transported methotrexate and folate, but not taurocholate and prostaglandin E2.	Folic Acid	131-137	solute carrier organic anion transporter family member 1A3	Rattus norvegicus	35-41
31005971-0	2019	The MTHFR 677C>T polymorphism is associated with unmetabolized folic acid in breast milk in a cohort of Canadian women.	Folic Acid	63-73	methylenetetrahydrofolate reductase	Homo sapiens	4-9
31005971-9	2019	However, the MTHFR 677C>T SNP was associated with breast-milk UMFA (R2 = 0.01; unadjusted P = 0.004), explaining a small portion of total variance; this association remained significant when adjusted for other covariates, including supplemental folic acid consumption.	Folic Acid	245-255	methylenetetrahydrofolate reductase	Homo sapiens	13-18
31005971-12	2019	The association between the MTHFR 677C>T SNP and breast-milk UMFA, albeit modest, highlights the need to better understand the determinants of breast-milk folate and the impact they might have on milk folate bioavailability.	Folic Acid	155-161	methylenetetrahydrofolate reductase	Homo sapiens	28-33
31005971-12	2019	The association between the MTHFR 677C>T SNP and breast-milk UMFA, albeit modest, highlights the need to better understand the determinants of breast-milk folate and the impact they might have on milk folate bioavailability.	Folic Acid	201-207	methylenetetrahydrofolate reductase	Homo sapiens	28-33
10101033-4	1999	When expressed in Xenopus oocytes, OAT-K2 stimulated the uptake of hydrophobic organic anions, such as taurocholate, methotrexate, folate, and prostaglandin E2, although its homolog OAT-K1 transported methotrexate and folate, but not taurocholate and prostaglandin E2.	Folic Acid	218-224	solute carrier organic anion transporter family member 1A3	Rattus norvegicus	35-41
10201405-3	1999	The flavoprotein methylenetetrahydrofolate reductase (MTHFR) is a likely target for these actions of folate.	Folic Acid	36-42	methylenetetrahydrofolate reductase	Homo sapiens	54-59
31393794-10	2019	High-dose folic acid supplement treatment exacerbated hypomethylation in MTHFR 677TT men compared with 677CC.	Folic Acid	10-20	methylenetetrahydrofolate reductase	Homo sapiens	73-78
31223065-8	2019	A high tumoral expression of the genes SLC46A1/PCFT, SLC19A1/RFC-1, ABCC3/MRP3, GGH, and MTHFD1L, which are involved in folate transport, polyglutamation, or metabolism, was associated with longer disease-free survival of the patients.	Folic Acid	120-126	replication factor C subunit 1	Homo sapiens	61-66
10201405-9	1999	Folate derivatives protect wild-type and mutant E. coli enzymes against flavin loss, and protect human MTHFR and the A222V mutant against thermal inactivation, suggesting a mechanism by which folate treatment reduces homocysteine levels.	Folic Acid	192-198	methylenetetrahydrofolate reductase	Homo sapiens	103-108
9987069-4	1999	To test this hypothesis, we examined changes in activity of the HGF/c-met system in the folic acid model of acute tubular injury and repair.	Folic Acid	88-98	hepatocyte growth factor	Mus musculus	64-67
9987069-5	1999	METHODS: Tissue HGF and c-met mRNA levels were detected by RNase protection assay and Northern blot analysis following acute renal injury induced by a single injection of folic acid.	Folic Acid	171-181	hepatocyte growth factor	Mus musculus	16-19
31143237-0	2019	The MTHFR C677T polymorphism influences the efficacy of folic acid supplementation on the nerve conduction studies in patients with diabetic polyneuropathy; A randomized, double blind, placebo-controlled study.	Folic Acid	56-66	methylenetetrahydrofolate reductase	Homo sapiens	4-9
31143237-1	2019	Background: Among patients with diabetic polyneuropathy, the status of folic acid, homocysteine, and nerve conduction studies (NCS) variations has been associated with methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms.	Folic Acid	71-81	methylenetetrahydrofolate reductase	Homo sapiens	168-203
9987069-8	1999	RESULTS: Extremely rapid induction of renal HGF and c-met mRNA was observed beginning one hour following injection of folic acid.	Folic Acid	118-128	hepatocyte growth factor	Mus musculus	44-47
31143237-1	2019	Background: Among patients with diabetic polyneuropathy, the status of folic acid, homocysteine, and nerve conduction studies (NCS) variations has been associated with methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms.	Folic Acid	71-81	methylenetetrahydrofolate reductase	Homo sapiens	205-210
31143237-8	2019	Results: Four months after intervention, patients significantly observed change of serum folic acid and homocysteine levels based on C677T genotypes in the MTHFR gene.	Folic Acid	89-99	methylenetetrahydrofolate reductase	Homo sapiens	156-161
10448518-5	1999	The widely studied one-carbon, reduced-folate transport system is mediated by a transporter encoded by the newly discovered RFC-1 (reduced-folate carrier) gene.	Folic Acid	39-45	replication factor C subunit 1	Homo sapiens	124-154
31143237-12	2019	Conclusion: The study determined that MTHFR C677T polymorphism effects the efficacy of folic acid supplementation on serum folic acid, homocysteine levels and some NCS parameters in diabetic polyneuropathy patients.	Folic Acid	87-97	methylenetetrahydrofolate reductase	Homo sapiens	38-43
31143237-12	2019	Conclusion: The study determined that MTHFR C677T polymorphism effects the efficacy of folic acid supplementation on serum folic acid, homocysteine levels and some NCS parameters in diabetic polyneuropathy patients.	Folic Acid	123-133	methylenetetrahydrofolate reductase	Homo sapiens	38-43
10448518-8	1999	RFC-1 gene expression also appears to regulate luminal epithelial cell folate absorption in small intestine.	Folic Acid	71-77	replication factor C subunit 1	Homo sapiens	0-5
21374032-4	1999	Most investigations into cellular resistance factors regulating 5-FU activity have focused on alterations in (TS) levels and reduced folate pools, the required cofactor for binding dUMP to thymidylate synthase (1).	Folic Acid	133-139	thymidylate synthase	Mus musculus	189-209
9806067-5	1998	Interventions known to prevent fatal outcome from ECM, such as splenectomy or treatment with anti-CD4 or anti-CD8 monoclonal antibodies, also prevented sensitivity to folic acid-induced convulsions.	Folic Acid	167-177	CD4 antigen	Mus musculus	98-101
9756990-1	1998	Mouse-liver gamma-glutamyl hydrolase (GH) is a lysosomal endopeptidase with an acid pH optimum that is activated by sulfhydryl compounds and preferentially hydrolyzes the most proximal gamma-glutamyl linkage of longer chain polyglutamates of folates and their analogues.	Folic Acid	242-249	gamma-glutamyl hydrolase	Mus musculus	12-36
9756990-1	1998	Mouse-liver gamma-glutamyl hydrolase (GH) is a lysosomal endopeptidase with an acid pH optimum that is activated by sulfhydryl compounds and preferentially hydrolyzes the most proximal gamma-glutamyl linkage of longer chain polyglutamates of folates and their analogues.	Folic Acid	242-249	gamma-glutamyl hydrolase	Mus musculus	38-40
9685395-3	1998	The complete folylpoly-gamma-glutamate carboxypeptidase cDNA was isolated from a pig jejunal cDNA library using an amplified homologous probe incorporating primer sequences from prostate-specific membrane antigen, a protein capable of folate hydrolysis.	Folic Acid	235-241	glutamate carboxypeptidase 2	Sus scrofa	13-55
9687553-0	1998	Methylenetetrahydrofolate reductase polymorphism affects the change in homocysteine and folate concentrations resulting from low dose folic acid supplementation in women with unexplained recurrent miscarriages.	Folic Acid	134-144	methylenetetrahydrofolate reductase	Homo sapiens	0-35
9663401-4	1998	It has been hypothesized that maternal folic acid supplementation prevents NTDs by partially correcting reduced MTHFR activity associated with the variant form of the enzyme.	Folic Acid	39-49	methylenetetrahydrofolate reductase	Homo sapiens	112-117
9625844-1	1998	Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in the folate cycle.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
9501215-4	1998	Patients of the cblE complementation group of disorders of folate/cobalamin metabolism who are defective in reductive activation of methionine synthase exhibit megaloblastic anemia, developmental delay, hyperhomocysteinemia, and hypomethioninemia.	Folic Acid	59-65	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	132-151
9562260-9	1998	In conclusion, the associations of creatinine levels and, inversely, of folate levels with plasma homocyst(e)ine levels in patients with TIA or MS are dependent on the 5,10-MTHFR mutation status.	Folic Acid	72-78	methylenetetrahydrofolate reductase	Homo sapiens	173-178
9622772-1	1998	OBJECTIVE: In the presence of low serum folate, mutant 5,20-methylenetetrahydrofolate reductase (MTHFR + [A223V/C677T]) in the homozygous state (+/+), may predispose to higher plasma homocysteine (tHct) levels and coronary artery disease (CAD).	Folic Acid	40-46	methylenetetrahydrofolate reductase	Homo sapiens	60-95
9622772-1	1998	OBJECTIVE: In the presence of low serum folate, mutant 5,20-methylenetetrahydrofolate reductase (MTHFR + [A223V/C677T]) in the homozygous state (+/+), may predispose to higher plasma homocysteine (tHct) levels and coronary artery disease (CAD).	Folic Acid	40-46	methylenetetrahydrofolate reductase	Homo sapiens	97-102
9622772-11	1998	A significant relation was shown between MTHFR genotype and low folate status yielding high tHct levels in those with the (+/+) genotype.	Folic Acid	64-70	methylenetetrahydrofolate reductase	Homo sapiens	41-46
9875554-4	1998	A comparison of the transport properties across the bile canalicular membrane in normal and mutant rats, whose cMOAT function is hereditarily defective, has shown that the physiologic role of cMOAT is to excrete LTC4, bilirubin glucuronides, 171-estradiol-170-D-glucuronide, and reduced folates.	Folic Acid	287-294	ATP binding cassette subfamily C member 2	Rattus norvegicus	192-197
9476397-0	1997	Time we increased folic acid consumption in Sri Lanka.	Folic Acid	18-28	sorcin	Homo sapiens	44-47
9244205-8	1997	Among control subjects, 12.7% were homozygous for the MTHFR T677 allele, and these women had higher plasma tHCY and lower plasma folate than women with other genotypes.	Folic Acid	129-135	methylenetetrahydrofolate reductase	Homo sapiens	54-59
9244205-11	1997	Although homozygosity for MTHFR T677 is related to increased plasma tHCY and low plasma folate, this genetic characteristic is not a risk factor for MI in this population.	Folic Acid	88-94	methylenetetrahydrofolate reductase	Homo sapiens	26-31
9247365-10	1997	Our study indicates that homozygosity for the 677C--&gt;T MTHFR mutation, especially in combination with low folate status, predisposes to high plasma levels of fasting tHcy.	Folic Acid	109-115	methylenetetrahydrofolate reductase	Homo sapiens	58-63
9519649-3	1997	Folic acid was assayed by a chromatographic method modified from that specified in the official monographs, for oil- and water-soluble vitamins with minerals tablets, in USP 23.	Folic Acid	0-10	ubiquitin specific peptidase 21	Homo sapiens	170-176
31003476-2	2019	Using the techniques of confocal imaging, quantitative reverse transcription-polymerase chain reaction (qRT-PCR), and small interfering (siRNA) knockdown against the PCFT, we demonstrated that Gl261 and A172 glioma cells, but not U87 and primary cultured astrocytes, express the PCFT, which provides selective internalization of folic acid (FA)-conjugated cytochrome c-containing nanoparticles (FA-Cyt c NPs), followed by cell death.	Folic Acid	329-339	solute carrier family 46, member 1	Mus musculus	166-170
9259028-6	1997	Homozygosity for thermolabile MTHFR deficiency has been identified as one important genetic factor, which expression is modified by dietary folate intake.	Folic Acid	140-146	methylenetetrahydrofolate reductase	Homo sapiens	30-35
30703509-7	2019	We found acute changes in serum and CSF levels of folate in exposed pups that coincided with increases in CSF Tau, whereas homocysteine in serum and CSF, and CSF levels of pTau were unchanged or remained below detection.	Folic Acid	50-56	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	36-39
9067278-2	1997	The enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR) catalyzes the conversion of 5,10-methylenetetrahydrofolate, required for purine and thymidine syntheses, to 5-methyltetrahydrofolate, the primary circulatory form of folate necessary for methionine synthesis.	Folic Acid	35-41	methylenetetrahydrofolate reductase	Homo sapiens	53-58
30703509-7	2019	We found acute changes in serum and CSF levels of folate in exposed pups that coincided with increases in CSF Tau, whereas homocysteine in serum and CSF, and CSF levels of pTau were unchanged or remained below detection.	Folic Acid	50-56	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	106-109
30703509-7	2019	We found acute changes in serum and CSF levels of folate in exposed pups that coincided with increases in CSF Tau, whereas homocysteine in serum and CSF, and CSF levels of pTau were unchanged or remained below detection.	Folic Acid	50-56	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	106-109
30703509-7	2019	We found acute changes in serum and CSF levels of folate in exposed pups that coincided with increases in CSF Tau, whereas homocysteine in serum and CSF, and CSF levels of pTau were unchanged or remained below detection.	Folic Acid	50-56	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	106-109
9067278-16	1997	In particular, these results suggest that the 677C--&gt;IT mutation in MTHFR reduces colon cancer risk, perhaps by increasing 5,10-methylenetetrahydrofolate levels for DNA synthesis, but that low folate intake or high alcohol consumption may negate some of the protective effect.	Folic Acid	150-156	methylenetetrahydrofolate reductase	Homo sapiens	71-76
9138952-2	1997	Our research team on prevention of birth defects could demonstrate that folic acid preventable NTDs are partly based on hyperhomocystinemia and a genetic predisposition (mutation of the methylenetetrahydrofolate-reductase gene (MTHF-R)).	Folic Acid	72-82	methylenetetrahydrofolate reductase	Homo sapiens	186-221
30649890-10	2019	In contrast, using the folate nephropathy model, we found reduced fibrosis and improved renal function in both Ltc4s-/- and Lta4h-/- mice.	Folic Acid	23-29	leukotriene C4 synthase	Mus musculus	111-116
9138952-2	1997	Our research team on prevention of birth defects could demonstrate that folic acid preventable NTDs are partly based on hyperhomocystinemia and a genetic predisposition (mutation of the methylenetetrahydrofolate-reductase gene (MTHF-R)).	Folic Acid	72-82	methylenetetrahydrofolate reductase	Homo sapiens	228-235
30603998-0	2019	Folic acid supplement use and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a case-control study.	Folic Acid	0-10	BRCA1 DNA repair associated	Homo sapiens	52-57
30603998-0	2019	Folic acid supplement use and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a case-control study.	Folic Acid	0-10	BRCA2 DNA repair associated	Homo sapiens	62-67
8994411-8	1997	CONCLUSIONS: Although it is accepted that moderate hyperhomocysteinemia significantly increases the risk for coronary, cerebrovascular, and peripheral vascular diseases, our data suggest that a mutation of the MTHFR gene, which has been associated with a thermolabile form of the enzyme and with hyperhomocysteinemia in subjects with plasma folate below the median, does not appear to be significantly associated with risk for premature coronary artery disease or for restenosis after coronary angioplasty.	Folic Acid	341-347	methylenetetrahydrofolate reductase	Homo sapiens	210-215
9381988-18	1997	This cell line is highly resistant to MTX, yet is still tumorigenic in vivo (24), and supplying the cells with high levels of exogenous folate can restore TS function (23).	Folic Acid	136-142	CREB binding protein	Rattus norvegicus	155-157
30603998-12	2019	CONCLUSIONS: In this first investigation of folic acid supplement use and breast cancer risk in BRCA mutation carriers, these findings suggest that moderate folic acid- and vitamin B12-containing supplement use may be protective for BRCA-associated breast cancer, particularly among BRCA1 mutation carriers.	Folic Acid	44-54	BRCA1 DNA repair associated	Homo sapiens	96-100
30603998-12	2019	CONCLUSIONS: In this first investigation of folic acid supplement use and breast cancer risk in BRCA mutation carriers, these findings suggest that moderate folic acid- and vitamin B12-containing supplement use may be protective for BRCA-associated breast cancer, particularly among BRCA1 mutation carriers.	Folic Acid	157-167	BRCA1 DNA repair associated	Homo sapiens	96-100
30603998-12	2019	CONCLUSIONS: In this first investigation of folic acid supplement use and breast cancer risk in BRCA mutation carriers, these findings suggest that moderate folic acid- and vitamin B12-containing supplement use may be protective for BRCA-associated breast cancer, particularly among BRCA1 mutation carriers.	Folic Acid	157-167	BRCA1 DNA repair associated	Homo sapiens	233-237
30603998-12	2019	CONCLUSIONS: In this first investigation of folic acid supplement use and breast cancer risk in BRCA mutation carriers, these findings suggest that moderate folic acid- and vitamin B12-containing supplement use may be protective for BRCA-associated breast cancer, particularly among BRCA1 mutation carriers.	Folic Acid	157-167	BRCA1 DNA repair associated	Homo sapiens	283-288
30502384-7	2019	Notably, overexpression of dihydrofolate reductase (DHFR) or exogenous addition of folate markedly reversed the astrocytes toxicity induced by MTX through activating folate metabolism pathway.	Folic Acid	34-40	dihydrofolate reductase	Mus musculus	52-56
30606816-9	2019	MTHFR-C677T altered protein turnover and folate mediated 1-carbon metabolic fluxes in lymphoblasts with and without MTX.	Folic Acid	41-47	methylenetetrahydrofolate reductase	Homo sapiens	0-5
30668559-7	2019	Comprehensive ova comparative transcriptomes indicated significant higher expression of genes encoding vitellogenin, chorions, and structural components in the extracellular matrix (ECM)-interaction pathway, enzymes in folate biosynthesis, and notably hormone synthesis in the domestic silkworm, compared to both the SP1 mutant and the wild silkworm.	Folic Acid	219-225	vitellogenin	Bombyx mori	103-115
30053573-4	2019	Polymorphisms in the Methyltetrahydrofolate Reductase (MTHFR) encoding gene, such as A1298C and C667T, are associated with the decreased bioavailability of folate, and this condition can act like folate deficiency.	Folic Acid	37-43	methylenetetrahydrofolate reductase	Homo sapiens	55-60
30631824-2	2019	Moreover, methylenetetrahydrofolate reductase (MTHFR) constitutes the primary enzyme of the folate pathway.	Folic Acid	29-35	methylenetetrahydrofolate reductase	Homo sapiens	47-52
30253388-9	2019	Finally, our data indicate that B12 and folic acid uptake might be influenced by vitamin D receptor and D3, where D3 and the BMI appear to have an indirect relationship - via B12 and folic acid.	Folic Acid	40-50	vitamin D receptor	Homo sapiens	81-99
29451831-0	2019	High-Dose Perinatal Folic-Acid Supplementation Alters Insulin Sensitivity in Sprague-Dawley Rats and Diminishes the Expression of Adiponectin.	Folic Acid	20-30	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	130-141
29451831-2	2019	This study was conducted to investigate the effects of prenatal and postnatal high folic acid supplementation (FAS) on glucose tolerance, insulin sensitivity, lipid metabolism, and expression of adiponectin in rats.	Folic Acid	83-93	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	195-206
30385507-2	2018	MPV17 loss-of-function has been reported to result in tissue-specific nucleotide pool imbalances, which can occur in states of perturbed folate-mediated one-carbon metabolism (FOCM), but MPV17 has not been directly linked to FOCM.	Folic Acid	137-143	mitochondrial inner membrane protein MPV17	Homo sapiens	0-5
30385507-5	2018	Depressed MPV17 expression reduced mitochondrial folate levels by 43% and increased uracil levels, a marker of impaired dTMP synthesis, in mtDNA by 3-fold.	Folic Acid	49-55	mitochondrial inner membrane protein MPV17	Homo sapiens	10-15
30385507-8	2018	We propose that MPV17 loss-of-function and related hepatocerebral MDS are linked to impaired FOCM in mitochondria by providing insufficient access to cytosolic dTMP pools and by severely reducing mitochondrial folate pools.	Folic Acid	210-216	mitochondrial inner membrane protein MPV17	Homo sapiens	16-21
30339177-0	2018	The 677C T variant of MTHFR is the major genetic modifier of biomarkers of folate status in a young, healthy Irish population.	Folic Acid	75-81	methylenetetrahydrofolate reductase	Homo sapiens	22-27
30339177-4	2018	Results: The 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C T (rs1801133) variant was the major genetic modifier of all 3 folate-related biomarkers in this Irish population and reached genome-wide significance for red blood cell folate (P = 1.37 x 10-17), serum folate (P = 2.82 x 10-11), and plasma total homocysteine (P = 1.26 x 10-19) concentrations.	Folic Acid	37-43	methylenetetrahydrofolate reductase	Homo sapiens	55-60
30339177-4	2018	Results: The 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C T (rs1801133) variant was the major genetic modifier of all 3 folate-related biomarkers in this Irish population and reached genome-wide significance for red blood cell folate (P = 1.37 x 10-17), serum folate (P = 2.82 x 10-11), and plasma total homocysteine (P = 1.26 x 10-19) concentrations.	Folic Acid	129-135	methylenetetrahydrofolate reductase	Homo sapiens	13-53
30339177-4	2018	Results: The 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C T (rs1801133) variant was the major genetic modifier of all 3 folate-related biomarkers in this Irish population and reached genome-wide significance for red blood cell folate (P = 1.37 x 10-17), serum folate (P = 2.82 x 10-11), and plasma total homocysteine (P = 1.26 x 10-19) concentrations.	Folic Acid	129-135	methylenetetrahydrofolate reductase	Homo sapiens	55-60
30339177-4	2018	Results: The 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C T (rs1801133) variant was the major genetic modifier of all 3 folate-related biomarkers in this Irish population and reached genome-wide significance for red blood cell folate (P = 1.37 x 10-17), serum folate (P = 2.82 x 10-11), and plasma total homocysteine (P = 1.26 x 10-19) concentrations.	Folic Acid	129-135	methylenetetrahydrofolate reductase	Homo sapiens	13-53
30339177-4	2018	Results: The 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C T (rs1801133) variant was the major genetic modifier of all 3 folate-related biomarkers in this Irish population and reached genome-wide significance for red blood cell folate (P = 1.37 x 10-17), serum folate (P = 2.82 x 10-11), and plasma total homocysteine (P = 1.26 x 10-19) concentrations.	Folic Acid	129-135	methylenetetrahydrofolate reductase	Homo sapiens	55-60
30339177-9	2018	Conclusions: The MTHFR 677C T variant is the predominant genetic modifier of folate status biomarkers in this healthy Irish population.	Folic Acid	77-83	methylenetetrahydrofolate reductase	Homo sapiens	17-22
30350398-6	2018	CONCLUSIONS: The effects of supplementation with folic acid + vitamin B12 and MOF on DNA methylation age are dependent upon gender and MTHFR genotype.	Folic Acid	49-59	methylenetetrahydrofolate reductase	Homo sapiens	135-140
24930442-8	2014	Maternal high-dose folic acid was associated with an increased rate of asthma medication among children: recurrent asthma medication IRR = 1.14 (95%CI: 1.04-1.30) and recurrent inhaled corticosteroids IRR = 1.26 (95%CI: 1.07-1.47).	Folic Acid	19-29	insulin receptor related receptor	Homo sapiens	133-136
24930442-8	2014	Maternal high-dose folic acid was associated with an increased rate of asthma medication among children: recurrent asthma medication IRR = 1.14 (95%CI: 1.04-1.30) and recurrent inhaled corticosteroids IRR = 1.26 (95%CI: 1.07-1.47).	Folic Acid	19-29	insulin receptor related receptor	Homo sapiens	201-204
25265565-1	2014	BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme of folate metabolic pathway which catalyzes the irreversible conversion of 5, 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	49-54
25935978-2	2014	MiR-122 has been considered to be specifically expressed in liver and involved in inducing hepatocyte apoptosis through bcl-w pathway, which could be efficiently bound to water dispersible positively charged gold nanoparticles and conjugated with folic acid (FA) to target specific cancer cells, through complementary electrostatic interaction.	Folic Acid	247-257	microRNA 122	Homo sapiens	0-7
25047451-1	2014	BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR), a key enzyme in folate metabolism, had significant effects on the homocysteine levels.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	49-54
24858690-0	2014	Folate in demethylation: the crystal structure of the rat dimethylglycine dehydrogenase complexed with tetrahydrofolate.	Folic Acid	0-6	dimethylglycine dehydrogenase	Rattus norvegicus	58-87
25221401-2	2014	With this background, we aim to hypothesize that whether C677T polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene contributes towards the risk of developing AD and its association with vitamin B12 and folate levels.	Folic Acid	98-104	methylenetetrahydrofolate reductase	Homo sapiens	116-121
25221401-8	2014	CONCLUSION: We concluded that the subjects with homozygous mutated alleles are more prone to AD and also pointed out the influence of presence/absence of MTHFR T allelic variants on serum folate and vitamin B12 levels.	Folic Acid	188-194	methylenetetrahydrofolate reductase	Homo sapiens	154-159
24749811-2	2014	We hypothesize that deficiency of maternal micronutrients such as folic acid and vitamin B12 will lead to increased oxidative stress, reduced long-chain polyunsaturated fatty acids, and altered expression of peroxisome proliferator activated receptor (PPARgamma) in the placenta, and omega-3 fatty acid supplementation to these diets will increase the expression of PPARgamma.	Folic Acid	66-76	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	252-261
24749811-2	2014	We hypothesize that deficiency of maternal micronutrients such as folic acid and vitamin B12 will lead to increased oxidative stress, reduced long-chain polyunsaturated fatty acids, and altered expression of peroxisome proliferator activated receptor (PPARgamma) in the placenta, and omega-3 fatty acid supplementation to these diets will increase the expression of PPARgamma.	Folic Acid	66-76	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	366-375
24747731-2	2014	10-Formyltetrahydrofolate dehydrogenase (FDH) is the most abundant folate enzyme in folate-mediated one-carbon metabolism.	Folic Acid	19-25	aldehyde dehydrogenase 1 family, member L1	Danio rerio	41-44
24725652-2	2014	The methylenetetrahydrofolate reductase (MTHFR) gene is a key determinant in the folate metabolism and previous studies reported a significant effect on AP-induced weight gain and related metabolic abnormalities.	Folic Acid	23-29	methylenetetrahydrofolate reductase	Homo sapiens	41-46
24744129-1	2014	Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme involved in folate metabolism, which is essential for DNA synthesis and methylation.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
24715612-7	2014	In order to elucidate the role of folate in the demethylating reaction we solved the crystal structure of the LSD1-CoREST-THF complex.	Folic Acid	34-40	lysine demethylase 1A	Homo sapiens	110-114
26835343-0	2014	Association of folate metabolism genes MTHFR and MTRR with multiple complex congenital malformation risk in Chinese population of Shanxi.	Folic Acid	15-21	methylenetetrahydrofolate reductase	Homo sapiens	39-44
26835343-3	2014	In the present study 250 Chinese birth defects cases who suffered 1-8 types of birth defect disease phenotypes were subjected and two genetic variants in two folate metabolism key enzymes, rs1801394 of methionine synthase reductase (MTRR) and rs1801133 of methylenetetrahydrofolate reductase (MTHFR) were genotyped by using SNaPshot method.	Folic Acid	158-164	methylenetetrahydrofolate reductase	Homo sapiens	256-291
26835343-3	2014	In the present study 250 Chinese birth defects cases who suffered 1-8 types of birth defect disease phenotypes were subjected and two genetic variants in two folate metabolism key enzymes, rs1801394 of methionine synthase reductase (MTRR) and rs1801133 of methylenetetrahydrofolate reductase (MTHFR) were genotyped by using SNaPshot method.	Folic Acid	158-164	methylenetetrahydrofolate reductase	Homo sapiens	293-298
24532086-1	2014	Low folate intake in the presence of the functional MTHFR 677 C &gt; T (rs1801133) polymorphism is an important cause of elevated homocysteine levels previously implicated in major depressive disorder (MDD) and many other chronic diseases.	Folic Acid	4-10	methylenetetrahydrofolate reductase	Homo sapiens	52-57
24532086-9	2014	Detection of the low-penetrance MTHFR 677 C &gt; T mutation reinforces the importance of folate intake above the recommended daily dose to prevent or restore dysfunction of the methylation pathway.	Folic Acid	89-95	methylenetetrahydrofolate reductase	Homo sapiens	32-37
24853127-3	2014	Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme involved in folate metabolism.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
24769206-1	2014	Methylenetetrahydrofolate reductase (MTHFR), a key enzyme in the folate cycle, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
24733041-6	2014	Significant differences were noted among various irradiated groups with and without the folate conjugation, with an average dose enhancement factor (DEF) of 1.64 +- 0.05 and 1.35 +- 0.05 for the folate-conjugated and pegylated GNPs, respectively.	Folic Acid	88-94	UTP25 small subunit processome component	Homo sapiens	149-152
24733041-6	2014	Significant differences were noted among various irradiated groups with and without the folate conjugation, with an average dose enhancement factor (DEF) of 1.64 +- 0.05 and 1.35 +- 0.05 for the folate-conjugated and pegylated GNPs, respectively.	Folic Acid	195-201	UTP25 small subunit processome component	Homo sapiens	149-152
24488626-1	2014	Methylenetetrahydrofolate reductase (MTHFR) is a central enzyme involved in regulating the metabolic function of folate, which plays a pivotal role in DNA synthesis, repair, and methylation.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
24966971-1	2014	Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme regulating the intracellular folate metabolism which plays an important role in carcinogenesis through DNA methylation.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
24460828-3	2014	Although the 5,10-methylenetetrahydrofolate reductase (MTHFR) enzyme participates in folate metabolism, several studies failed to find any association between NSCL/P and the MTHFR C677T and A1298C polymorphisms.	Folic Acid	37-43	methylenetetrahydrofolate reductase	Homo sapiens	55-60
24710923-6	2014	It was found that transient folate deprivation combined with SMs was sufficient to permit reprogramming from mouse embryonic fibroblasts (MEFs) in the presence of transcription factors, Oct4 and Klf4, within 25 days, replacing Sox2 and c-Myc, and accelerated the generation of mouse iPSCs.	Folic Acid	28-34	SRY (sex determining region Y)-box 2	Mus musculus	227-231
9381988-19	1997	Thus in TS- Cl/Cl cells, the TS phenotype is conditionally dependent upon the presence of high levels of exogenous folate.	Folic Acid	115-121	CREB binding protein	Rattus norvegicus	8-10
9381988-19	1997	Thus in TS- Cl/Cl cells, the TS phenotype is conditionally dependent upon the presence of high levels of exogenous folate.	Folic Acid	115-121	CREB binding protein	Rattus norvegicus	29-31
9381988-20	1997	This suggests that a role of rTS proteins as conditional down-regulators of TS, perhaps through modulating folate binding, may be possible.	Folic Acid	107-113	CREB binding protein	Rattus norvegicus	29-32
9381988-20	1997	This suggests that a role of rTS proteins as conditional down-regulators of TS, perhaps through modulating folate binding, may be possible.	Folic Acid	107-113	CREB binding protein	Rattus norvegicus	30-32
9381988-24	1997	Since K562 B1A cells overproduce rTS beta (2), but have no significant alterations in FPGS activity, the possibility that rTS may affect folate binding remains a hypothesis worth examining.	Folic Acid	137-143	CREB binding protein	Rattus norvegicus	122-125
8921781-3	1996	The enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR) catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, the predominant circulatory form of folate, which serves as a methyl donor for remethylation of homocysteine to methionine.	Folic Acid	35-41	methylenetetrahydrofolate reductase	Homo sapiens	53-58
8934221-0	1996	The hematological effects of folate analogs: implications for using the dihydrofolate reductase gene for in vivo selection.	Folic Acid	29-35	dihydrofolate reductase	Mus musculus	72-95
8901666-10	1996	MTHFR, which modulates basal plasma homocysteine concentration, is folate dependent, and dietary supplementation or fortification with folic acid may reduce plasma homocysteine levels and consequent coronary risk in a significant proportion of the general population.	Folic Acid	67-73	methylenetetrahydrofolate reductase	Homo sapiens	0-5
8935478-7	1996	The MTHFR thermolabile genotype should be considered when population studies are designed to determine the effective homocysteine-lowering dose of dietary folate supplements, and when prophylactic doses of folate are recommended for individuals.	Folic Acid	155-161	methylenetetrahydrofolate reductase	Homo sapiens	4-9
8673125-0	1996	Prenatal folic acid treatment suppresses acrania and meroanencephaly in mice mutant for the Cart1 homeobox gene.	Folic Acid	9-19	ALX homeobox 1	Mus musculus	92-97
8673125-4	1996	Prenatal treatment of Cart1 homozygous mutants with folic acid suppresses the development of the acrania/meroanencephaly phenotype.	Folic Acid	52-62	ALX homeobox 1	Mus musculus	22-27
7726158-2	1995	This form of folate is generated from 5,10-methylenetetrahydrofolate through the action of 5,10-methylenetetrahydrofolate reductase (MTHFR), a cytosolic flavoprotein.	Folic Acid	13-19	methylenetetrahydrofolate reductase	Homo sapiens	91-131
30355657-9	2018	Addition of tetrahydrobiopterin (BH4) to AHF rats lung lysates and pretreatment of AHF rats with folic acid (FA) prevented ROS production indicating endothelial NOS (eNOS) uncoupling.Conclusion: Pressure-dependent NOS activation leads to acute endothelial hyperpermeability and rapid PE by an increase in NO and ROS in a model of AHF.	Folic Acid	97-107	nitric oxide synthase 3	Rattus norvegicus	149-164
7726158-2	1995	This form of folate is generated from 5,10-methylenetetrahydrofolate through the action of 5,10-methylenetetrahydrofolate reductase (MTHFR), a cytosolic flavoprotein.	Folic Acid	13-19	methylenetetrahydrofolate reductase	Homo sapiens	133-138
7893997-3	1994	In this report, changes in the expression of three other genes in response to folic acid injury have been investigated: ornithine decarboxylase, epidermal growth factor (EGF), and sulfated glycoprotein-2 (SGP-2).	Folic Acid	78-88	ornithine decarboxylase, structural 1	Mus musculus	120-143
30524952-7	2018	We report that significant changes in metabolites induced by E2 and SFN were associated with differences in glycolysis and energy metabolism, and also amino acid, purine, and folic acid metabolism.	Folic Acid	175-185	cystatin 12, pseudogene	Homo sapiens	61-71
7874164-1	1994	Three folate-sensitive fragile sites, termed FRAXA, FRAXE and FRAXF, have been identified on the distal end of chromosome Xq.	Folic Acid	6-12	transmembrane protein 185A	Homo sapiens	62-67
7918371-1	1994	The function of the hydrophobic residues Leu28, Phe31, Ile50, and Leu54 at the folate binding site in Escherichia coli dihydrofolate reductase (5,6,7,8-tetrahydrofolate: NADP+ oxidoreductase, EC 1.5.1.3) has been studied by a combination of site-specific mutagenesis and reaction kinetics.	Folic Acid	79-85	oxidoreductase	Escherichia coli	176-190
30401001-5	2018	The degree of tHcy reduction associated with long-term folic acid supplementation can be significantly affected by sex, MTHFR C677T genotypes, baseline folate, tHcy, eGFR levels and smoking status.	Folic Acid	55-65	methylenetetrahydrofolate reductase	Homo sapiens	120-125
1482756-4	1992	After it was first demonstrated that folic acid increased renal clusterin mRNA in the rat, a species in which renal clusterin was highly inducible by other stimuli, the effects of folic acid (250 mg/kg ip) on clusterin mRNA and immunoreactivity were examined in mice sufficient and deficient for the fifth component of complement.	Folic Acid	37-47	clusterin	Rattus norvegicus	64-73
30178194-3	2018	Proton-coupled folate transporter (PCFT) and reduced folate carrier (RFC) are the major folate transporters responsible for folate uptake at basolateral membrane of hepatocytes.	Folic Acid	15-21	solute carrier family 46, member 1	Mus musculus	35-39
1516048-2	1992	LV administration increases the level of reduced folates in tissues, which promotes the inhibition of TS.	Folic Acid	49-56	thymidylate synthase	Mus musculus	102-104
30341286-2	2018	In this study, we demonstrated that EZH2 and H3K27me3 were upregulated in the murine kidney with AKI induced by either ischemia-reperfusion (I/R) or folic acid (FA).	Folic Acid	149-159	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	36-40
1655252-1	1991	L1210-B73 cells, variants of L1210 cells grown in medium containing nanomolar concentrations of folates, express a membrane associated folate binding protein (mFBP) in addition to the classical reduced folate/methotrexate carrier (RF/MTX-carrier) present in L1210 cells grown in standard high folate medium (G. Jansen et al., Cancer Res., 49: 1959-1963, 1989).	Folic Acid	135-141	far upstream element (FUSE) binding protein 1	Mus musculus	159-163
29574721-3	2018	In this study, we found that folate deficiency inhibited Vangl gene expression and Vangl protein binding to the ligand Dvl.	Folic Acid	29-35	dishevelled segment polarity protein 1	Mus musculus	119-122
30120883-3	2018	This study aims to evaluate the association between genetic defects in folate metabolism pathway genes, mainly: Folate hydrolase 1 (FOLH1), Dihydrofolate reductase (DHFR) and Methylenetetrahydrofolate reductase (MTHFR) and neural tube defects from eastern India.	Folic Acid	71-77	methylenetetrahydrofolate reductase	Homo sapiens	175-210
30120883-3	2018	This study aims to evaluate the association between genetic defects in folate metabolism pathway genes, mainly: Folate hydrolase 1 (FOLH1), Dihydrofolate reductase (DHFR) and Methylenetetrahydrofolate reductase (MTHFR) and neural tube defects from eastern India.	Folic Acid	71-77	methylenetetrahydrofolate reductase	Homo sapiens	212-217
1655252-1	1991	L1210-B73 cells, variants of L1210 cells grown in medium containing nanomolar concentrations of folates, express a membrane associated folate binding protein (mFBP) in addition to the classical reduced folate/methotrexate carrier (RF/MTX-carrier) present in L1210 cells grown in standard high folate medium (G. Jansen et al., Cancer Res., 49: 1959-1963, 1989).	Folic Acid	135-141	far upstream element (FUSE) binding protein 1	Mus musculus	159-163
1655252-2	1991	In this study we used L1210-B73 and L1210 cells as a model system to study the affinity of the RF/MTX-carrier and the mFBP for the natural folate compounds folic acid and 5-formyltetrahydrofolate (5-CHO-THF), as well as a number of antifolate compounds.	Folic Acid	139-145	far upstream element (FUSE) binding protein 1	Mus musculus	118-122
1655252-2	1991	In this study we used L1210-B73 and L1210 cells as a model system to study the affinity of the RF/MTX-carrier and the mFBP for the natural folate compounds folic acid and 5-formyltetrahydrofolate (5-CHO-THF), as well as a number of antifolate compounds.	Folic Acid	156-166	far upstream element (FUSE) binding protein 1	Mus musculus	118-122
1655252-7	1991	Binding affinities of the mFBP decreased in the order CB3717 greater than or equal to folic acid = ICI-198,583 greater than or equal to 5-CHO-THF much greater than MTX = 10-EdAM.	Folic Acid	86-96	far upstream element (FUSE) binding protein 1	Mus musculus	26-30
1655252-8	1991	Over 24 h, at 25 nM, [3H]folic acid uptake in L1210-B73 cells was found to proceed for more than 98% via the mFBP.	Folic Acid	25-35	far upstream element (FUSE) binding protein 1	Mus musculus	109-113
2094778-1	1990	A population survey of a common folate-sensitive fragile site, fra(3)(p14), was carried out on PHA-stimulated peripheral lymphocytes of 1,078 healthy subjects.	Folic Acid	32-38	ribonuclease P/MRP subunit p14	Homo sapiens	70-73
29796841-1	2018	OBJECTIVES: The study investigated the association between plasma homocysteine, folate and vitamin B12 with 5,10 methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), thymidylate synthase (TYMS 2R   3R) and methionine synthase (MTR A2756G) polymorphisms and methotrexate (MTX) treatment and toxicity in Tunisian Rheumatoid arthritis (RA) patients.	Folic Acid	80-86	methylenetetrahydrofolate reductase	Homo sapiens	150-155
33803677-3	2021	Folic acid (FA) conjugated amphiphilic block copolymer (folic acid-polyethylene glycol-poly (beta-benzyl-L-aspartate)10, FA-PEG-PBLA10) was employed to encapsulate 3TT-IC-4Cl by nano-precipitation to form stable nanoparticles (TNPs), and TNPs exhibit excellent photothermal stability and photothermal conversion efficiency.	Folic Acid	0-10	C1GALT1 specific chaperone 1	Homo sapiens	227-231
29882091-2	2018	PURPOSE: To evaluate the possibility of correcting metabolic defects in gametes and embryos due to methylene tetra hydrofolate reductase (MTHFR) isoforms C677T and A1298C, by supplementation with 5-methyl THF instead of synthetic folic acid.	Folic Acid	230-240	methylenetetrahydrofolate reductase	Homo sapiens	99-136
29882091-2	2018	PURPOSE: To evaluate the possibility of correcting metabolic defects in gametes and embryos due to methylene tetra hydrofolate reductase (MTHFR) isoforms C677T and A1298C, by supplementation with 5-methyl THF instead of synthetic folic acid.	Folic Acid	230-240	methylenetetrahydrofolate reductase	Homo sapiens	138-143
33803677-3	2021	Folic acid (FA) conjugated amphiphilic block copolymer (folic acid-polyethylene glycol-poly (beta-benzyl-L-aspartate)10, FA-PEG-PBLA10) was employed to encapsulate 3TT-IC-4Cl by nano-precipitation to form stable nanoparticles (TNPs), and TNPs exhibit excellent photothermal stability and photothermal conversion efficiency.	Folic Acid	0-10	C1GALT1 specific chaperone 1	Homo sapiens	238-242
33802362-3	2021	MTHFR(677) CT and TT genotypes have been associated with a greater risk of low birth weight, especially in case of deficient intake of folic acid during pregnancy.	Folic Acid	135-145	methylenetetrahydrofolate reductase	Homo sapiens	0-5
29979702-1	2018	ALDH1L1 is a folate-metabolizing enzyme abundant in liver and several other tissues.	Folic Acid	13-19	aldehyde dehydrogenase 1 family, member L1	Mus musculus	0-7
29876984-1	2018	The folate biosynthetic pathway and its key enzyme dihydrofolate reductase (DHFR) is a popular target for drug development due to its essential role in the synthesis of DNA precursors and some amino acids.	Folic Acid	4-10	dihydrofolate reductase	Arabidopsis thaliana	51-74
29876984-1	2018	The folate biosynthetic pathway and its key enzyme dihydrofolate reductase (DHFR) is a popular target for drug development due to its essential role in the synthesis of DNA precursors and some amino acids.	Folic Acid	4-10	dihydrofolate reductase	Arabidopsis thaliana	76-80
29551366-9	2018	Loss of the only known Dictyostelium MAPK kinase, MekA, prevented the phosphorylation of Erk1 but not Erk2 in response to folate and cAMP confirming that Erk2 is not regulated by a conventional MAP2K.	Folic Acid	122-128	phosducin	Homo sapiens	50-54
29524840-1	2018	Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme involved in folate metabolism and plays a central role in DNA methylation and biosynthesis.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
29524840-2	2018	MTHFR mutations may alter the cellular folate supply which in turn affects nucleic acid synthesis, DNA methylation and chromosomal damage.	Folic Acid	39-45	methylenetetrahydrofolate reductase	Homo sapiens	0-5
29571225-0	2018	Folic acid delays development of atherosclerosis in low-density lipoprotein receptor-deficient mice.	Folic Acid	0-10	low density lipoprotein receptor	Mus musculus	52-84
30061759-1	2018	Background: The gene for 5,10-methylenetetrahydrofolate reductase (NAD(P)H) or MTHFR gene encodes protein methylenetetrahydrofolate reductase (MTHFR), an enzyme important in folate metabolism.	Folic Acid	49-55	2,4-dienoyl-CoA reductase 1	Homo sapiens	67-75
30061759-1	2018	Background: The gene for 5,10-methylenetetrahydrofolate reductase (NAD(P)H) or MTHFR gene encodes protein methylenetetrahydrofolate reductase (MTHFR), an enzyme important in folate metabolism.	Folic Acid	49-55	methylenetetrahydrofolate reductase	Homo sapiens	79-84
30061759-1	2018	Background: The gene for 5,10-methylenetetrahydrofolate reductase (NAD(P)H) or MTHFR gene encodes protein methylenetetrahydrofolate reductase (MTHFR), an enzyme important in folate metabolism.	Folic Acid	49-55	methylenetetrahydrofolate reductase	Homo sapiens	106-141
30061759-1	2018	Background: The gene for 5,10-methylenetetrahydrofolate reductase (NAD(P)H) or MTHFR gene encodes protein methylenetetrahydrofolate reductase (MTHFR), an enzyme important in folate metabolism.	Folic Acid	49-55	methylenetetrahydrofolate reductase	Homo sapiens	143-148
29644791-7	2018	The methylation levels of 3 CpG sites (cg15200711, cg19462022, and cg07035602) in LPCAT1 and RASA3 genes are associated with fiber (false discovery rate [FDR] &lt; 0.05) after adjustment for covariates including folic acid.	Folic Acid	212-222	lysophosphatidylcholine acyltransferase 1	Homo sapiens	82-88
29588419-7	2018	Additionally, folic acid-induced AKI in mice resulted in increased expression of Fn14 and necroptosis mediators, such as receptor-interacting protein kinase 1 (RIPK1), RIPK3, and mixed lineage domain-like protein (MLKL).	Folic Acid	14-24	receptor-interacting serine-threonine kinase 3	Mus musculus	168-173
29588419-7	2018	Additionally, folic acid-induced AKI in mice resulted in increased expression of Fn14 and necroptosis mediators, such as receptor-interacting protein kinase 1 (RIPK1), RIPK3, and mixed lineage domain-like protein (MLKL).	Folic Acid	14-24	mixed lineage kinase domain-like	Mus musculus	214-218
29360980-2	2018	We recently detected an unexpected loss of DNA methylation in the sperm of idiopathic infertile men after 6 months of daily supplementation with 5 mg folic acid (&gt;10x the daily recommended intake-DRI), exacerbated in men homozygous for a common variant in the gene encoding an important enzyme in folate metabolism, methylenetetrahydrofolate reductase (MTHFR 677C&gt;T).	Folic Acid	150-160	methylenetetrahydrofolate reductase	Homo sapiens	319-354
29360980-2	2018	We recently detected an unexpected loss of DNA methylation in the sperm of idiopathic infertile men after 6 months of daily supplementation with 5 mg folic acid (&gt;10x the daily recommended intake-DRI), exacerbated in men homozygous for a common variant in the gene encoding an important enzyme in folate metabolism, methylenetetrahydrofolate reductase (MTHFR 677C&gt;T).	Folic Acid	150-160	methylenetetrahydrofolate reductase	Homo sapiens	356-361
29371246-0	2018	MTHFR Gene and Serum Folate Interaction on Serum Homocysteine Lowering: Prospect for Precision Folic Acid Treatment.	Folic Acid	95-105	methylenetetrahydrofolate reductase	Homo sapiens	0-5
29371246-8	2018	Our data raised the prospect to tailor folic acid therapy according to individual MTHFR C677T genotype and folate status.	Folic Acid	39-49	methylenetetrahydrofolate reductase	Homo sapiens	82-87
28004270-10	2018	Homozygous (T/T) or heterozygous (C/T) women for MTHFR-C677T had lower plasma folate concentrations [C/T: -6.48% (p value = 0.038) and T/T: -15.89% (p value &lt;0.001)] compared to women carrying the C/C genotype.	Folic Acid	78-84	methylenetetrahydrofolate reductase	Homo sapiens	49-54
29903290-13	2018	CONCLUSION: The present Meta-analysis suggests that MTHFR C677T is significantly associated with maternal risk for NTDs in the Chinese population, supplemental folic acid supplementation based on MTHFR polymorphisms will be an important means to further reduce the birth defects of newborns.	Folic Acid	160-170	methylenetetrahydrofolate reductase	Homo sapiens	52-57
29903290-13	2018	CONCLUSION: The present Meta-analysis suggests that MTHFR C677T is significantly associated with maternal risk for NTDs in the Chinese population, supplemental folic acid supplementation based on MTHFR polymorphisms will be an important means to further reduce the birth defects of newborns.	Folic Acid	160-170	methylenetetrahydrofolate reductase	Homo sapiens	196-201
29447234-0	2018	Folic acid derived-P5779 mimetics regulate DAMP-mediated inflammation through disruption of HMGB1:TLR4:MD-2 axes.	Folic Acid	0-10	lymphocyte antigen 96	Homo sapiens	103-107
29447234-4	2018	Molecular dynamic (MD) simulation studies demonstrate that folic acid mimics the binding of P5779 at the TLR4 and MD-2 intersection.	Folic Acid	59-69	lymphocyte antigen 96	Homo sapiens	114-118
29162511-4	2018	METHODS: We investigated if major polymorphisms of folate-related genes, namely MTHFR c.677C>T, MTR c.2756A>G, MTRR c.66A>G and TYMS TSER (a 28-bp tandem repeat in the 5" promoter enhancer region of TYMS) increase the risk of pathological changes of the thymus in AChR+ MG patients.	Folic Acid	51-57	methylenetetrahydrofolate reductase	Homo sapiens	80-85
29191785-0	2018	Folate-targeted liposomal nitrooxy-doxorubicin: An effective tool against P-glycoprotein-positive and folate receptor-positive tumors.	Folic Acid	0-6	phosphoglycolate phosphatase	Mus musculus	74-88
29191785-3	2018	Here we produced the first liposomal formulations of this nitrooxy-doxorubicin decorated with folic acid (FA), termed LNDF, in order to improve their active targeting against Pgp-expressing tumors.	Folic Acid	94-104	phosphoglycolate phosphatase	Mus musculus	175-178
29382057-8	2018	Similar to C3G, neutral pH also has a prominent effect on the degradation of PGA, which is further accelerated by heating.	Folic Acid	77-80	Rap guanine nucleotide exchange factor 1	Homo sapiens	11-14
29382057-9	2018	The C3G-rich fraction exhibited dose-dependent inhibitory effects on cell metabolic activity when the HepG2 cells were exposed for 48 h. Interestingly, PGA but not PCA exhibited cytotoxic effects against both MDA-MB-231 and HepG2 cells.	Folic Acid	152-155	Rap guanine nucleotide exchange factor 1	Homo sapiens	4-7
29222906-2	2018	In a case-control study we investigated C677T polymorphism in the 5,10- methylenetetrahydrofolate reductase (MTHFR) gene in case and control mothers of Pakistani origin, and compared these with the respective maternal folate concentrations measured at the time of delivery.	Folic Acid	91-97	methylenetetrahydrofolate reductase	Homo sapiens	109-114
29737822-1	2018	BACKGROUND AND OBJECTIVES: Methylenetetrahydrofolate reductase (MTHFR) irreversibly converts 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, which is the main form of folate used in the body.	Folic Acid	46-52	methylenetetrahydrofolate reductase	Homo sapiens	64-69
29737822-2	2018	Previous studies suggest that MTHFR polymorphism influences folate metabolism, but conflicting results are reported.	Folic Acid	60-66	methylenetetrahydrofolate reductase	Homo sapiens	30-35
29737822-3	2018	We performed a meta-analysis to accurately characterize the association between MTHFR A1298C polymorphism and peripheral blood folate concentration in healthy populations.	Folic Acid	127-133	methylenetetrahydrofolate reductase	Homo sapiens	80-85
29737822-7	2018	Significant differences in folate concentration were found in the MTHFR homozygote model (SMD=0.12, 95% CI=0.00-0.24, I2=17%, p=0.04) and the dominant model (SMD=0.07, 95% CI=0.01-0.14, I2=22%, p=0.02) in the general population excluding the elderly.	Folic Acid	27-33	methylenetetrahydrofolate reductase	Homo sapiens	66-71
29737822-9	2018	CONCLUSIONS: This meta-analysis indicates that, in the general population excluding the elderly, the C allele of MTHFR 1298 polymorphism is associated with the risk for an increased folate concentration.	Folic Acid	182-188	methylenetetrahydrofolate reductase	Homo sapiens	113-118
29461227-3	2018	Polymorphism of the 5,10-methylenetetrahydrofolate reductase gene (MTHFR) is a genetic determinant of folate metabolism violation.	Folic Acid	44-50	methylenetetrahydrofolate reductase	Homo sapiens	67-72
29461227-14	2018	It includes determining the level of homocysteine and the MTHFR polymorphisms (in the case of hyperhomocysteinemia), which will identify the required dose of folic acid.	Folic Acid	158-168	methylenetetrahydrofolate reductase	Homo sapiens	58-63
30592864-0	2018	[Assessment of the sufficiency of Moscow population with folic acid, depending on the combined effect of polymorphism of MTHFR and FTO genes].	Folic Acid	57-67	methylenetetrahydrofolate reductase	Homo sapiens	121-126
30592864-1	2018	The results of assessing the sufficiency of folic acid of the residents of the Moscow region have been presented depending on rs1801133 MTHFR gene polymorphism and rs9939609 FTO gene polymorphism.	Folic Acid	44-54	methylenetetrahydrofolate reductase	Homo sapiens	136-141
28833104-3	2017	Colonic folate levels of CRC were inversely correlated with pluripotent expressions of the SOX2, NANOG and OCT4 markers (p &lt; 0.05).	Folic Acid	8-14	SRY-box transcription factor 2	Homo sapiens	91-95
28833104-3	2017	Colonic folate levels of CRC were inversely correlated with pluripotent expressions of the SOX2, NANOG and OCT4 markers (p &lt; 0.05).	Folic Acid	8-14	Nanog homeobox	Homo sapiens	97-102
28778973-3	2017	We investigated the association between folic acid supplementation during pregnancy and loss of imprinting (LOI) of IGF2 and H19 genes in placentas and cord blood of 90 mother-child dyads in association with the methylenetetrahydrofolate reductase (MTHFR) genotype.	Folic Acid	40-50	methylenetetrahydrofolate reductase	Homo sapiens	212-247
28778973-3	2017	We investigated the association between folic acid supplementation during pregnancy and loss of imprinting (LOI) of IGF2 and H19 genes in placentas and cord blood of 90 mother-child dyads in association with the methylenetetrahydrofolate reductase (MTHFR) genotype.	Folic Acid	40-50	methylenetetrahydrofolate reductase	Homo sapiens	249-254
29390492-2	2017	Functional variants of the methylenetetrahydrofolate reductase (MTHFR) gene result in disturbance in folate metabolism and may affect susceptibility to cancer.	Folic Acid	46-52	methylenetetrahydrofolate reductase	Homo sapiens	64-69
29176804-5	2017	Cardiac defects, including smaller chamber size, aberrant cardiac function and cmlc2 expression pattern, were also apparent in folate deficient embryos.	Folic Acid	127-133	myosin, light chain 7, regulatory	Danio rerio	79-84
28906345-0	2017	Folic acid exerts antidepressant effects by upregulating brain-derived neurotrophic factor and glutamate receptor 1 expression in brain.	Folic Acid	0-10	brain-derived neurotrophic factor	Rattus norvegicus	57-90
28906345-6	2017	In conclusion, the results showed that folic acid significantly improved depression-like behaviors in CUMS-induced rats, and its antidepressant effects might be related to the increase of brain 5-HT concentration, BDNF and GluR1 expression, and repair of synaptic organization in the brain.	Folic Acid	39-49	brain-derived neurotrophic factor	Rattus norvegicus	214-218
28885847-2	2017	Folate transport in mammalian tissues is mediated by three major folate transport systems, i.e., reduced folate carrier (RFC), proton-coupled folate transporter (PCFT), and folate receptor alpha (FRalpha), known to be regulated by ligand-activated nuclear receptors, such as vitamin D receptor (VDR).	Folic Acid	0-6	vitamin D receptor	Homo sapiens	275-293
28885847-2	2017	Folate transport in mammalian tissues is mediated by three major folate transport systems, i.e., reduced folate carrier (RFC), proton-coupled folate transporter (PCFT), and folate receptor alpha (FRalpha), known to be regulated by ligand-activated nuclear receptors, such as vitamin D receptor (VDR).	Folic Acid	0-6	vitamin D receptor	Homo sapiens	295-298
28885847-5	2017	The objective of this study was to investigate the role of RFC in folate uptake at the level of the blood-brain barrier (BBB) and its potential regulation by VDR.	Folic Acid	66-72	vitamin D receptor	Homo sapiens	158-161
28994615-1	2017	AIM: To investigate the relationships of polymorphisms in genes whose protein products are related in the metabolic pathway of folic acid, particularly MTRR A66G, RFC1 G80A, and MTHFR C677T and A1298C, and disease activity in Mexican patients with rheumatoid arthritis (RA) treated with methotrexate (MTX).	Folic Acid	127-137	replication factor C subunit 1	Homo sapiens	163-167
29259859-2	2017	Methylene Tetrahydrofolate Reductase (MTHFR) is one of the major enzymes of the folate metabolism pathway.	Folic Acid	20-26	methylenetetrahydrofolate reductase	Homo sapiens	38-43
29259859-10	2017	MTHFR promoter methylation affects folate metabolism which is known to play a role in chromosomal breakage, abnormal chromosomal segregation and genomic instability and therefore a developmental defect in the form of congenital cardiac anomaly.	Folic Acid	35-41	methylenetetrahydrofolate reductase	Homo sapiens	0-5
28545845-4	2017	Here, we show that claudins are essential for neural tube closure: the simultaneous removal of Cldn3, -4 and -8 from tight junctions caused folate-resistant open neural tube defects.	Folic Acid	140-146	claudin 3	Homo sapiens	95-111
27774577-2	2017	Folate is a methyl donor during DNA methylation, as it provides substrate for methylenetetrahydrofolate reductase (MTHFR) to convert 5,10-MTHF to 5-MTHF and subsequently metabolizes it to methionine.	Folic Acid	0-6	methylenetetrahydrofolate reductase	Homo sapiens	78-113
28355497-0	2017	Molecular characterization of dihydroneopterin aldolase and aminodeoxychorismate synthase in common bean-genes coding for enzymes in the folate synthesis pathway.	Folic Acid	137-143	AT695_RS00200	Staphylococcus aureus	30-55
28355497-2	2017	Genes coding for dihydroneopterin aldolase (DHNA) and aminodeoxychorismate synthase (ADCS) of the folate synthesis pathway were characterized by PCR amplification, BAC clone sequencing, and whole genome sequencing.	Folic Acid	98-104	AT695_RS00200	Staphylococcus aureus	17-42
28355497-2	2017	Genes coding for dihydroneopterin aldolase (DHNA) and aminodeoxychorismate synthase (ADCS) of the folate synthesis pathway were characterized by PCR amplification, BAC clone sequencing, and whole genome sequencing.	Folic Acid	98-104	AT695_RS00200	Staphylococcus aureus	44-48
28537809-3	2017	Methionine synthase (MTR) and methionine synthase reductase (MTRR) are critical enzymes for the folate cycle.	Folic Acid	96-102	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	0-19
28165156-0	2017	Pancreatic impairment and Igf2 hypermethylation induced by developmental exposure to bisphenol A can be counteracted by maternal folate supplementation.	Folic Acid	129-135	insulin-like growth factor 2	Rattus norvegicus	26-30
28165156-5	2017	Importantly, maternal dietary folate supplementation was demonstrated to negate this Igf2 DNA hypermethylation in the offspring, which was consistent with the upregulation of Igf2 expression.	Folic Acid	30-36	insulin-like growth factor 2	Rattus norvegicus	85-89
28165156-5	2017	Importantly, maternal dietary folate supplementation was demonstrated to negate this Igf2 DNA hypermethylation in the offspring, which was consistent with the upregulation of Igf2 expression.	Folic Acid	30-36	insulin-like growth factor 2	Rattus norvegicus	175-179
28165156-6	2017	Overall, our results suggest that early developmental exposure to BPA alters the DNA methylation of Igf2, that these altered methylation patterns are associated with impaired beta-cell function in the offspring and that these effects can be counteracted by maternal folate supplementation.	Folic Acid	266-272	insulin-like growth factor 2	Rattus norvegicus	100-104
28580921-3	2017	hTS binds 2"-deoxyuridine 5"-monophosphate (dUMP) and the folate co-substrate N5,N10-methylenetetrahydrofolate (meTHF) in a pocket near the catalytic residue Cys195.	Folic Acid	58-64	APC down-regulated 1	Homo sapiens	0-3
28398657-2	2017	METHODS: We evaluated nutrient intake using 24-hr recall, assessing the levels of serum folate, RBC folate, serum B12 , and homocysteine, as well as determining genetic variants of the enzyme MTHFR (C677T and A1298C) and CbetaS (844ins68pb).	Folic Acid	100-106	methylenetetrahydrofolate reductase	Homo sapiens	192-197
28277784-3	2017	Methylene tetrahydrofolate reductase (MTHFR) is an important enzyme in the MTX pathway and is involved in folate metabolism and DNA synthesis.	Folic Acid	20-26	methylenetetrahydrofolate reductase	Homo sapiens	38-43
28277784-9	2017	In addition, RA patients with the MTHFR C677T polymorphism who were supplemented with folic acid displayed significantly elevated risk for MTX toxicity.	Folic Acid	86-96	methylenetetrahydrofolate reductase	Homo sapiens	34-39
28544525-8	2017	Also, MTHFR gene A1298C polymorphism in the partial folate supplementation group showed a relationship with decreased MTX efficacy (CCvs.	Folic Acid	52-58	methylenetetrahydrofolate reductase	Homo sapiens	6-11
28373541-5	2017	The alleles under natural selection at two of these loci [methylenetetrahydrofolate reductase (MTHFR) and EPAS1] are strongly associated with blood-related phenotypes, such as hemoglobin, homocysteine, and folate in Tibetans.	Folic Acid	77-83	methylenetetrahydrofolate reductase	Homo sapiens	95-100
28400561-0	2017	A hybrid stochastic model of folate-mediated one-carbon metabolism: Effect of the common C677T MTHFR variant on de novo thymidylate biosynthesis.	Folic Acid	29-35	methylenetetrahydrofolate reductase	Homo sapiens	95-100
28400561-2	2017	Mouse models of folate-responsive neural tube defects (NTDs) indicate that impaired de novo thymidylate (dTMP) synthesis through changes in SHMT expression is causative in folate-responsive NTDs.	Folic Acid	16-22	serine hydroxymethyltransferase 1 (soluble)	Mus musculus	140-144
28400561-2	2017	Mouse models of folate-responsive neural tube defects (NTDs) indicate that impaired de novo thymidylate (dTMP) synthesis through changes in SHMT expression is causative in folate-responsive NTDs.	Folic Acid	172-178	serine hydroxymethyltransferase 1 (soluble)	Mus musculus	140-144
28702146-1	2017	BACKGROUND: The 5, 10-methyleneterahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) are two essential enzymes involved in folate metabolism.	Folic Acid	40-46	methylenetetrahydrofolate reductase	Homo sapiens	58-63
28862175-1	2017	BACKGROUND &amp; OBJECTIVES: Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme of folate metabolism, whose role in schizophrenia is debatable.	Folic Acid	48-54	methylenetetrahydrofolate reductase	Homo sapiens	66-71
28345657-9	2017	Furthermore, the folic acid (FA) &amp;AVR2 (human VEGF antibody)-coated NP-MVs are exploited to target the tumor location, and the feasibility of this approach has been confirmed empirically.	Folic Acid	17-27	vascular endothelial growth factor A	Mus musculus	50-54
27771938-7	2017	CONCLUSIONS: Data provide strong evidence that surface UV-irradiance reduces long-term systemic folate levels, and that this is influenced by the C677T-MTHFR gene variant.	Folic Acid	96-102	methylenetetrahydrofolate reductase	Homo sapiens	152-157
27771938-8	2017	We speculate this effect may be due to 677TT-MTHFR individuals containing more 5,10CH2 -H4 PteGlu, and that this folate form may be particularly UV labile.	Folic Acid	91-97	methylenetetrahydrofolate reductase	Homo sapiens	45-50
26820674-1	2017	Methylenetetrahydrofolate reductase (MTHFR) is key enzyme of folate/homocysteine pathway.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
28191262-6	2017	RESULTS: Maternal dietary and supplemental intake of methyl-group donors (folate, betaine, folic acid), only in the periconception period, was associated with buccal cell DNA methylation in genes related to growth (IGF2 DMR), metabolism (RXRA), and appetite control (LEP).	Folic Acid	74-80	WD repeat domain 20	Homo sapiens	220-223
28191262-6	2017	RESULTS: Maternal dietary and supplemental intake of methyl-group donors (folate, betaine, folic acid), only in the periconception period, was associated with buccal cell DNA methylation in genes related to growth (IGF2 DMR), metabolism (RXRA), and appetite control (LEP).	Folic Acid	74-80	retinoid X receptor alpha	Homo sapiens	238-242
28191262-6	2017	RESULTS: Maternal dietary and supplemental intake of methyl-group donors (folate, betaine, folic acid), only in the periconception period, was associated with buccal cell DNA methylation in genes related to growth (IGF2 DMR), metabolism (RXRA), and appetite control (LEP).	Folic Acid	91-101	WD repeat domain 20	Homo sapiens	220-223
28191262-6	2017	RESULTS: Maternal dietary and supplemental intake of methyl-group donors (folate, betaine, folic acid), only in the periconception period, was associated with buccal cell DNA methylation in genes related to growth (IGF2 DMR), metabolism (RXRA), and appetite control (LEP).	Folic Acid	91-101	retinoid X receptor alpha	Homo sapiens	238-242
28191262-8	2017	Positive associations were observed for maternal betaine (slope = 0.875, 95% CI 0.118; 1.633, p = 0.0241) and folate (slope = 0.685, 95% CI 0.245; 1.125, p = 0.0027) intake before pregnancy and RXRA methylation.	Folic Acid	110-116	retinoid X receptor alpha	Homo sapiens	194-198
26497154-2	2017	As genetic variability of MTHFR influences folate status, it is important to ensure an adequate intake that overrides genetic effects but minimises any adverse effects.	Folic Acid	43-49	methylenetetrahydrofolate reductase	Homo sapiens	26-31
26497154-0	2017	The impact of MTHFR 677 C/T genotypes on folate status markers: a meta-analysis of folic acid intervention studies.	Folic Acid	41-47	methylenetetrahydrofolate reductase	Homo sapiens	14-19
26497154-1	2017	PURPOSE: Methylenetetrahydrofolate reductase (MTHFR) is a key folate pathway enzyme with the T variant of the MTHFR gene increasing the risk of low folate status, particularly coupled with low folate intake.	Folic Acid	28-34	methylenetetrahydrofolate reductase	Homo sapiens	46-51
26497154-1	2017	PURPOSE: Methylenetetrahydrofolate reductase (MTHFR) is a key folate pathway enzyme with the T variant of the MTHFR gene increasing the risk of low folate status, particularly coupled with low folate intake.	Folic Acid	28-34	methylenetetrahydrofolate reductase	Homo sapiens	110-115
26497154-1	2017	PURPOSE: Methylenetetrahydrofolate reductase (MTHFR) is a key folate pathway enzyme with the T variant of the MTHFR gene increasing the risk of low folate status, particularly coupled with low folate intake.	Folic Acid	62-68	methylenetetrahydrofolate reductase	Homo sapiens	9-44
26497154-1	2017	PURPOSE: Methylenetetrahydrofolate reductase (MTHFR) is a key folate pathway enzyme with the T variant of the MTHFR gene increasing the risk of low folate status, particularly coupled with low folate intake.	Folic Acid	62-68	methylenetetrahydrofolate reductase	Homo sapiens	46-51
26497154-1	2017	PURPOSE: Methylenetetrahydrofolate reductase (MTHFR) is a key folate pathway enzyme with the T variant of the MTHFR gene increasing the risk of low folate status, particularly coupled with low folate intake.	Folic Acid	62-68	methylenetetrahydrofolate reductase	Homo sapiens	110-115
26497154-6	2017	RESULTS: The MTHFR 677TT genotype was associated with higher plasma homocysteine (2.7 mumol/L, TT vs. CT/CC; 2.8 mumol/L, TT vs. CC) and lower serum folate (2.5 nmol/L, TT vs. CT/CC; 3.6 nmol/L, TT vs. CC).	Folic Acid	149-155	methylenetetrahydrofolate reductase	Homo sapiens	13-18
26497154-10	2017	CONCLUSIONS: This meta-analysis confirms observations from observational and intervention studies that MTHFR TT genotype is associated with increased plasma homocysteine and lowered serum folate and less response to short-term supplementation.	Folic Acid	188-194	methylenetetrahydrofolate reductase	Homo sapiens	103-108
27384413-10	2017	For example, the effect of MTHFR 1298C appeared to be different between those mothers below US RDA folate intake (RR = 0.98) versus those at or above US RDA folate intake (RR = 0.68), but the interaction was not statistically significant (interaction p = 0.27).	Folic Acid	99-105	methylenetetrahydrofolate reductase	Homo sapiens	27-32
27384413-10	2017	For example, the effect of MTHFR 1298C appeared to be different between those mothers below US RDA folate intake (RR = 0.98) versus those at or above US RDA folate intake (RR = 0.68), but the interaction was not statistically significant (interaction p = 0.27).	Folic Acid	157-163	methylenetetrahydrofolate reductase	Homo sapiens	27-32
27845046-2	2017	Here we report a T-DNA insertion mutant (atdfb-3) of the plastidial folylpolyglutamate synthetase gene (AtDFB) was defective in folate metabolism and nitrogen metabolism under nitrate-limited conditions in darkness.	Folic Acid	128-134	DHFS-FPGS homolog B	Arabidopsis thaliana	41-46
27845046-2	2017	Here we report a T-DNA insertion mutant (atdfb-3) of the plastidial folylpolyglutamate synthetase gene (AtDFB) was defective in folate metabolism and nitrogen metabolism under nitrate-limited conditions in darkness.	Folic Acid	128-134	DHFS-FPGS homolog B	Arabidopsis thaliana	104-109
27830979-8	2017	Taking folic acid supplements during the entire pregnancy resulted in statistically significantly higher cord blood RXRA methylation as compared with stopping supplementation in the second trimester (12.3 +- 1.9% vs. 11.1 +- 2%, P = 0.008 for RXRA mean CpG).	Folic Acid	7-17	retinoid X receptor alpha	Homo sapiens	116-120
27830979-8	2017	Taking folic acid supplements during the entire pregnancy resulted in statistically significantly higher cord blood RXRA methylation as compared with stopping supplementation in the second trimester (12.3 +- 1.9% vs. 11.1 +- 2%, P = 0.008 for RXRA mean CpG).	Folic Acid	7-17	retinoid X receptor alpha	Homo sapiens	243-247
27830979-9	2017	To conclude, long-term folic acid use before and during pregnancy was associated with higher LEP and RXRA cord blood methylation, respectively.	Folic Acid	23-33	retinoid X receptor alpha	Homo sapiens	101-105
28118645-1	2017	Polymorphisms in genes encoding the enzymes involved in the metabolism of homocysteine, such as methionine synthase (MTR) and methionine synthase reductase (MTRR), play an important function in the metabolism of folic acid and vitamin B12.	Folic Acid	212-222	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	96-115
27846450-3	2017	Folic acid was conjugated to hydroxyl group from the multiblock polymer through DCC-NHS coupling.	Folic Acid	0-10	DCC netrin 1 receptor	Homo sapiens	80-83
27755385-11	2017	CONCLUSION: MTHFR is important for regulating transmethylation processes and is involved in regulation of folate metabolism.	Folic Acid	106-112	methylenetetrahydrofolate reductase	Homo sapiens	12-17
28654384-2	2017	The aim of this research was to evaluate the fluorescent properties and the plasmonic-photothermal, therapeutic, and radiotherapeutic potential of 177Lu-dendrimer conjugated to folate and bombesin with gold nanoparticles in the dendritic cavity (177Lu-DenAuNP-folate-bombesin) when it is internalized in T47D breast cancer cells.	Folic Acid	177-183	gastrin releasing peptide	Homo sapiens	267-275
28081274-2	2016	Methylenetetrahydrofolate reductase (MTHFR) plays a vital role in folate metabolism, DNA methylation, and RNA synthesis.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
27755291-1	2016	BACKGROUND: The rationale of the current study was to test the clinical utility of the folate pathway genetic polymorphisms in predicting the risk for autism spectrum disorders (ASD) and to address the inconsistencies in the association of MTHFR C677T and hyperhomocysteinemia with ASD.	Folic Acid	87-93	methylenetetrahydrofolate reductase	Homo sapiens	240-245
27916838-2	2016	We hypothesized that genetic variants in methylenetetrahydrofolate reductase (MTHFR), a key enzyme of folate metabolism, would affect the prognosis of prostate cancer.	Folic Acid	60-66	methylenetetrahydrofolate reductase	Homo sapiens	78-83
24624460-5	1993	MANAGEMENT: Treatment of manifestations: Treatment for mild EPB42-HS (Hgb 11-15 g/dL, reticulocytes 3%-8%) includes folic acid supplementation (400 microg 1x daily until age 1 year; 1 mg 1x daily thereafter) and RBC transfusion as needed for a hemolytic or aplastic crisis.	Folic Acid	116-126	erythrocyte membrane protein band 4.2	Homo sapiens	60-65
27442847-17	2016	When the orange by-product and amaranth flour were added to mMRS, all strains were able to increase folate production after 24h of fermentation.	Folic Acid	100-106	sterile alpha motif domain containing 11	Mus musculus	60-64
27442847-22	2016	lactis BB-12 (237+-23ng/mL) were also able to produce folate after growth in mMRS containing acerola and orange by-products, respectively.	Folic Acid	54-60	sterile alpha motif domain containing 11	Mus musculus	77-81
27428365-5	2016	Arabidopsis thaliana MRP1 is already known to be involved in vacuolar storage of folates.	Folic Acid	81-88	multidrug resistance-associated protein 1	Arabidopsis thaliana	21-25
28520345-2	2012	Genetic variations in the MTHFR gene can lead to impaired function or inactivation of this enzyme, which results in mildly elevated levels of homocysteine, especially in individuals who are also deficient in folate (1).	Folic Acid	208-214	methylenetetrahydrofolate reductase	Homo sapiens	26-31
27783031-12	2016	Subjects with MTHFR 1793 G/A genotype along with low serum folate concentration demonstrated the lowest name and orientation abilities.	Folic Acid	59-65	methylenetetrahydrofolate reductase	Homo sapiens	14-19
27605737-8	2016	In conclusion, this meta-analysis demonstrates a strong association between the MTHFR C677T variant and RPL in Asian population and raising the importance of the use of folate in its treatment and prevention.	Folic Acid	169-175	methylenetetrahydrofolate reductase	Homo sapiens	80-85
26559681-3	2016	The aim of our study was to explore the response of tHcy in hemodialysis (HD) patients to individual supplementation with folic acid (B9) and/or vitamin B12, based on carrier status for the (MTHFR) polymorphism.	Folic Acid	122-132	methylenetetrahydrofolate reductase	Homo sapiens	191-196
27708721-0	2016	The impact of MTHFR 677C   T risk knowledge on changes in folate intake: findings from the Food4Me study.	Folic Acid	58-64	methylenetetrahydrofolate reductase	Homo sapiens	14-19
27465373-1	2016	BACKGROUND: B vitamins [vitamins B-6, B-9 (folate), and B-12] play important roles in nucleotide biosynthesis and biological methylation reactions, aberrancies of which have all been implicated in carcinogenesis.	Folic Acid	43-49	NADH:ubiquinone oxidoreductase subunit A3	Homo sapiens	33-41
27465373-10	2016	CONCLUSIONS: Our data suggest that elevated plasma folate concentrations may be associated with increased risk of breast cancer in women with a BRCA1/2 mutation.	Folic Acid	51-57	BRCA1 DNA repair associated	Homo sapiens	144-151
27369467-3	2016	DNA methylation reactions rely on the cellular availability of methyl donors, which are primarily products of folate metabolism, where a key enzyme is methylenetetrahydrofolate reductase (MTHFR).	Folic Acid	110-116	methylenetetrahydrofolate reductase	Homo sapiens	151-186
27369467-3	2016	DNA methylation reactions rely on the cellular availability of methyl donors, which are primarily products of folate metabolism, where a key enzyme is methylenetetrahydrofolate reductase (MTHFR).	Folic Acid	110-116	methylenetetrahydrofolate reductase	Homo sapiens	188-193
27221465-7	2016	Post-administration of both folic and ascorbic acids together in hyperthyroid rats showed the best ameliorating effects on the thyroid hormones, testosterone, testicular GGT and ALP, and all oxidative stress markers.	Folic Acid	28-33	PDZ and LIM domain 3	Rattus norvegicus	178-181
27260448-0	2016	A sensitive and selective on-line amperometric sulfite biosensor using sulfite oxidase immobilized on a magnetite-gold-folate nanocomposite modified carbon-paste electrode.	Folic Acid	119-125	sulfite oxidase	Homo sapiens	71-86
27315223-0	2016	Suppression of MTHFD2 in MCF-7 Breast Cancer Cells Increases Glycolysis, Dependency on Exogenous Glycine, and Sensitivity to Folate Depletion.	Folic Acid	125-131	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	Homo sapiens	15-21
24500934-10	2014	In contrast, Shmt1(tg+) mice exhibited a 30% reduction in tumor incidence, a 50% reduction in tumor number, and a 60% reduction in tumor load compared with wild-type mice independent of dietary folate intake.	Folic Acid	194-200	serine hydroxymethyltransferase 1 (soluble)	Mus musculus	13-18
24112451-1	2014	BACKGROUND: While several single nucleotide polymorphisms are known to influence the metabolism of folate, the methylene tetrahydrofolate reductase (MTHFR) gene has been the most extensively studied.	Folic Acid	99-105	methylenetetrahydrofolate reductase	Homo sapiens	111-147
24112451-1	2014	BACKGROUND: While several single nucleotide polymorphisms are known to influence the metabolism of folate, the methylene tetrahydrofolate reductase (MTHFR) gene has been the most extensively studied.	Folic Acid	99-105	methylenetetrahydrofolate reductase	Homo sapiens	149-154
24502980-0	2014	The methylation status of the platelet-derived growth factor-B gene promoter and its regulation of cellular proliferation following folate treatment in human glioma cells.	Folic Acid	132-138	platelet derived growth factor subunit B	Homo sapiens	30-62
24737431-2	2014	Since methylenetetrahydrofolate reductase (MTHFR) is an important enzyme involved in folate metabolism, in this study, we examined whether polymorphisms and haplotypes of MTHFR are correlated with the risk of gastric cancer.	Folic Acid	25-31	methylenetetrahydrofolate reductase	Homo sapiens	43-48
24737431-2	2014	Since methylenetetrahydrofolate reductase (MTHFR) is an important enzyme involved in folate metabolism, in this study, we examined whether polymorphisms and haplotypes of MTHFR are correlated with the risk of gastric cancer.	Folic Acid	25-31	methylenetetrahydrofolate reductase	Homo sapiens	171-176
24478121-3	2014	The small N4 cavity of the ring-contracted porphyrinoid results in an intermediate spin (i.s., S=3/2) state as the ground state for the iron(III) ion.	Folic Acid	10-12	spindlin 1	Homo sapiens	83-87
23996892-10	2014	CONCLUSION: Our data demonstrated that reduced MTHFR activities associated with the MTHFR T allele may interact with RBC folate as the risk modifiers of lymphocytic p53 oxidative lesions of HCC patients.	Folic Acid	121-127	methylenetetrahydrofolate reductase	Homo sapiens	47-52
23996892-10	2014	CONCLUSION: Our data demonstrated that reduced MTHFR activities associated with the MTHFR T allele may interact with RBC folate as the risk modifiers of lymphocytic p53 oxidative lesions of HCC patients.	Folic Acid	121-127	methylenetetrahydrofolate reductase	Homo sapiens	84-89
24365028-11	2014	MTHFR is an enzyme involved in the folate pathway and in de novo nucleotide biosynthesis but also a good example for gene-environment interaction in phenotype development.	Folic Acid	35-41	methylenetetrahydrofolate reductase	Homo sapiens	0-5
24615072-8	2014	Moreover, H. pylori infection, folate intake, and location of the tumor showed a significant interaction with the MTHFR C677T polymorphism.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	114-119
24615072-9	2014	Our study suggests a protective role of MTHFR 677TT and high folate intake against gastric cancer, and the effect of the MTHFR C677T genotype may differ by H. pylori infection, folate consumption, and tumor site.	Folic Acid	177-183	methylenetetrahydrofolate reductase	Homo sapiens	121-126
24177262-10	2014	Moreover, folic acid significantly attenuated LPS-induced expression of placental MyD88.	Folic Acid	10-20	myeloid differentiation primary response gene 88	Mus musculus	82-87
24177262-11	2014	Additionally, folic acid inhibited LPS-induced c-Jun NH2-terminal kinase (JNK) phosphorylation and nuclear factor kappa B (NF-kappaB) activation in placentas.	Folic Acid	14-24	mitogen-activated protein kinase 8	Mus musculus	47-72
24177262-11	2014	Additionally, folic acid inhibited LPS-induced c-Jun NH2-terminal kinase (JNK) phosphorylation and nuclear factor kappa B (NF-kappaB) activation in placentas.	Folic Acid	14-24	mitogen-activated protein kinase 8	Mus musculus	74-77
24294939-9	2014	The efflux (basolaterial to apical) of folic acid was enhanced only by the high dose of EPO treatment, which was associated with the significant up-regulation of apical multidrug resistance-associated protein 2 (MRP2).	Folic Acid	39-49	ATP binding cassette subfamily C member 2	Homo sapiens	169-210
24294939-9	2014	The efflux (basolaterial to apical) of folic acid was enhanced only by the high dose of EPO treatment, which was associated with the significant up-regulation of apical multidrug resistance-associated protein 2 (MRP2).	Folic Acid	39-49	ATP binding cassette subfamily C member 2	Homo sapiens	212-216
24512081-2	2014	However, it was only recently that the proton-coupled folate transporter (PCFT) was identified and its critical role in folate transport across the apical brush-border membrane of the proximal small intestine established by the loss-of-function mutations identified in the PCFT gene in subjects with hereditary folate malabsorption and, more recently, by the Pcft-null mouse.	Folic Acid	54-60	solute carrier family 46, member 1	Mus musculus	74-78
24512081-2	2014	However, it was only recently that the proton-coupled folate transporter (PCFT) was identified and its critical role in folate transport across the apical brush-border membrane of the proximal small intestine established by the loss-of-function mutations identified in the PCFT gene in subjects with hereditary folate malabsorption and, more recently, by the Pcft-null mouse.	Folic Acid	54-60	solute carrier family 46, member 1	Mus musculus	273-277
24512081-2	2014	However, it was only recently that the proton-coupled folate transporter (PCFT) was identified and its critical role in folate transport across the apical brush-border membrane of the proximal small intestine established by the loss-of-function mutations identified in the PCFT gene in subjects with hereditary folate malabsorption and, more recently, by the Pcft-null mouse.	Folic Acid	54-60	solute carrier family 46, member 1	Mus musculus	359-363
24512081-2	2014	However, it was only recently that the proton-coupled folate transporter (PCFT) was identified and its critical role in folate transport across the apical brush-border membrane of the proximal small intestine established by the loss-of-function mutations identified in the PCFT gene in subjects with hereditary folate malabsorption and, more recently, by the Pcft-null mouse.	Folic Acid	120-126	solute carrier family 46, member 1	Mus musculus	39-72
24512081-2	2014	However, it was only recently that the proton-coupled folate transporter (PCFT) was identified and its critical role in folate transport across the apical brush-border membrane of the proximal small intestine established by the loss-of-function mutations identified in the PCFT gene in subjects with hereditary folate malabsorption and, more recently, by the Pcft-null mouse.	Folic Acid	120-126	solute carrier family 46, member 1	Mus musculus	74-78
24512081-2	2014	However, it was only recently that the proton-coupled folate transporter (PCFT) was identified and its critical role in folate transport across the apical brush-border membrane of the proximal small intestine established by the loss-of-function mutations identified in the PCFT gene in subjects with hereditary folate malabsorption and, more recently, by the Pcft-null mouse.	Folic Acid	120-126	solute carrier family 46, member 1	Mus musculus	273-277
24512081-2	2014	However, it was only recently that the proton-coupled folate transporter (PCFT) was identified and its critical role in folate transport across the apical brush-border membrane of the proximal small intestine established by the loss-of-function mutations identified in the PCFT gene in subjects with hereditary folate malabsorption and, more recently, by the Pcft-null mouse.	Folic Acid	120-126	solute carrier family 46, member 1	Mus musculus	359-363
24512081-6	2014	The impact of a variety of ions, organic molecules, and drugs on PCFT-mediated folate transport is described.	Folic Acid	79-85	solute carrier family 46, member 1	Mus musculus	65-69
25003120-7	2014	Results suggest that maternal micronutrient imbalance (excess folic acid with vitamin B12 deficiency) leads to lower mRNA levels of methylene tetrahydrofolate reductase (MTHFR) and methionine synthase , but higher cystathionine b-synthase (CBS) and Phosphatidylethanolamine-N-methyltransferase (PEMT) as compared to control.	Folic Acid	62-72	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	249-293
25003120-7	2014	Results suggest that maternal micronutrient imbalance (excess folic acid with vitamin B12 deficiency) leads to lower mRNA levels of methylene tetrahydrofolate reductase (MTHFR) and methionine synthase , but higher cystathionine b-synthase (CBS) and Phosphatidylethanolamine-N-methyltransferase (PEMT) as compared to control.	Folic Acid	62-72	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	295-299
24839819-1	2014	BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is the key enzyme for folate metabolism.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	49-54
25297611-0	2014	A cross-sectional study to find out the relationship of methylenetetrahydrofolate reductase (MTHFR) C677T genotype with plasma levels of folate and total homocysteine by daily folate intake in Japanese.	Folic Acid	75-81	methylenetetrahydrofolate reductase	Homo sapiens	93-98
25297611-0	2014	A cross-sectional study to find out the relationship of methylenetetrahydrofolate reductase (MTHFR) C677T genotype with plasma levels of folate and total homocysteine by daily folate intake in Japanese.	Folic Acid	137-143	methylenetetrahydrofolate reductase	Homo sapiens	56-91
25297611-0	2014	A cross-sectional study to find out the relationship of methylenetetrahydrofolate reductase (MTHFR) C677T genotype with plasma levels of folate and total homocysteine by daily folate intake in Japanese.	Folic Acid	137-143	methylenetetrahydrofolate reductase	Homo sapiens	93-98
24338216-1	2014	Methylenetetrahydrofolate reductase (MTHFR) gene plays a pivotal role in folate metabolism.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
24639841-6	2014	For those who had folate intake&lt;450 ug/day, MTHFR 667TT genotype was associated with a higher risk of breast cancer (OR=2.45, 95% CI=1.09-5.82, P=0.02).	Folic Acid	18-24	methylenetetrahydrofolate reductase	Homo sapiens	47-52
24639841-8	2014	A significant interaction was observed between MTHFR C667T polymorphism and folate intake on the risk of breast cancer (P for interaction was 0.025).	Folic Acid	76-82	methylenetetrahydrofolate reductase	Homo sapiens	47-52
24639841-9	2014	CONCLUSION: This case-control study found a significant association between MTHFR C667T polymorphism, folate intake and vitamin B6 and breast cancer risk, and a significant interaction was observed between MTHFR C667T polymorphism and folate intake on the risk of breast cancer.	Folic Acid	235-241	methylenetetrahydrofolate reductase	Homo sapiens	76-81
24639841-9	2014	CONCLUSION: This case-control study found a significant association between MTHFR C667T polymorphism, folate intake and vitamin B6 and breast cancer risk, and a significant interaction was observed between MTHFR C667T polymorphism and folate intake on the risk of breast cancer.	Folic Acid	235-241	methylenetetrahydrofolate reductase	Homo sapiens	206-211
24014085-1	2014	Methylenetetrahydrofolate reductase (MTHFR) is one of the most important enzymes for folate metabolism which plays a key role in cell metabolism.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
23459165-2	2013	The single nucleotide polymorphisms, MTHFR C677T, A1298C, MTR A2756G and MTRR A66G, cause alteration in the homocysteine levels and reduced enzymatic activity that generates deficiency in the assimilation of folates associated with DNA damage; that is, why it is important to know if the single nucleotide polymorphisms are associated with the pathological characteristics and development of prostate cancer, through a case-control retrospective study.	Folic Acid	208-215	methylenetetrahydrofolate reductase	Homo sapiens	37-42
24108782-11	2013	However, low serum folate was associated with high MGMT methylation (P = 0.001).	Folic Acid	19-25	O-6-methylguanine-DNA methyltransferase	Homo sapiens	51-55
24532985-7	2013	It is believed that the increase in the concentration of Hcy in PD can affect genetic polymorphisms of the folate metabolic pathway genes, such as MTHFR (C677T, A1298C and G1793A), MTR (A2756G), and MTHFD1 (G1958A), whose frequencies tend to increase in PD patients, as well as the reduced concentration of B vitamins.	Folic Acid	107-113	methylenetetrahydrofolate reductase	Homo sapiens	147-152
23595572-8	2013	Stratified analyses by plasma folate low (&lt;7.4 ng/ml) or high (&gt;=7.4 ng/ml) suggested significantly higher OR of CKD for those with MTHFR C677T T/T and low serum folate with the aOR of 2.07 (95 % CI 1.30-3.31) compared with that for those with MTHFR C677T T/T and high serum folate.	Folic Acid	30-36	methylenetetrahydrofolate reductase	Homo sapiens	138-143
23595572-8	2013	Stratified analyses by plasma folate low (&lt;7.4 ng/ml) or high (&gt;=7.4 ng/ml) suggested significantly higher OR of CKD for those with MTHFR C677T T/T and low serum folate with the aOR of 2.07 (95 % CI 1.30-3.31) compared with that for those with MTHFR C677T T/T and high serum folate.	Folic Acid	30-36	methylenetetrahydrofolate reductase	Homo sapiens	250-255
23595572-8	2013	Stratified analyses by plasma folate low (&lt;7.4 ng/ml) or high (&gt;=7.4 ng/ml) suggested significantly higher OR of CKD for those with MTHFR C677T T/T and low serum folate with the aOR of 2.07 (95 % CI 1.30-3.31) compared with that for those with MTHFR C677T T/T and high serum folate.	Folic Acid	168-174	methylenetetrahydrofolate reductase	Homo sapiens	138-143
23595572-8	2013	Stratified analyses by plasma folate low (&lt;7.4 ng/ml) or high (&gt;=7.4 ng/ml) suggested significantly higher OR of CKD for those with MTHFR C677T T/T and low serum folate with the aOR of 2.07 (95 % CI 1.30-3.31) compared with that for those with MTHFR C677T T/T and high serum folate.	Folic Acid	168-174	methylenetetrahydrofolate reductase	Homo sapiens	138-143
24551672-10	2013	In conclusion, polymorphism of the MTHFR 677T is associated with small differences in BMD with folate levels.	Folic Acid	95-101	methylenetetrahydrofolate reductase	Homo sapiens	35-40
24048573-3	2013	5,10-Methylenetetrahydrofolate reductase (MTHFR) is a key folate pathway enzyme involved in providing methyl groups from dietary folate for DNA methylation.	Folic Acid	24-30	methylenetetrahydrofolate reductase	Homo sapiens	42-47
23969624-12	2013	A common genetic variant of the MTHFR gene might impact the treatment effect of folate augmentation.	Folic Acid	80-86	methylenetetrahydrofolate reductase	Homo sapiens	32-37
24101362-10	2013	For SAH, interactions between MTR and MTHFR polymorphisms, and MTHFR polymorphism and serum folate were found.	Folic Acid	92-98	methylenetetrahydrofolate reductase	Homo sapiens	63-68
23959833-3	2013	It is still controversial and ambiguous between the functional polymorphisms of folate metabolism genes 5,10-methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTRR), and methionine synthase reductase (MTR) and risk of adult meningioma.	Folic Acid	80-86	methylenetetrahydrofolate reductase	Homo sapiens	104-144
23959833-3	2013	It is still controversial and ambiguous between the functional polymorphisms of folate metabolism genes 5,10-methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTRR), and methionine synthase reductase (MTR) and risk of adult meningioma.	Folic Acid	80-86	methylenetetrahydrofolate reductase	Homo sapiens	146-151
23959833-3	2013	It is still controversial and ambiguous between the functional polymorphisms of folate metabolism genes 5,10-methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTRR), and methionine synthase reductase (MTR) and risk of adult meningioma.	Folic Acid	80-86	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	154-173
23845215-1	2013	OBJECTIVE: Our earlier studies show that maternal diets imbalanced in micronutrients like folic acid and vitamin B12 reduced brain docosahexaenoic acid (DHA) and brain derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in the offspring at birth and postnatal d21.	Folic Acid	90-100	brain-derived neurotrophic factor	Rattus norvegicus	162-195
23845215-1	2013	OBJECTIVE: Our earlier studies show that maternal diets imbalanced in micronutrients like folic acid and vitamin B12 reduced brain docosahexaenoic acid (DHA) and brain derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in the offspring at birth and postnatal d21.	Folic Acid	90-100	brain-derived neurotrophic factor	Rattus norvegicus	197-201
24068460-4	2013	Therefore, we carried out a meta-analysis of 26, 17, 9, 15, 9 and 6 case-control studies on the relationship between maternal methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, methionine synthase (MTR) A2756G, methionine synthase reductase (MTRR) A66G, reduced folate carrier 1 A80G and cystathionine beta-synthase 844ins68 polymorphisms and the risk of having a DS offspring.	Folic Acid	145-151	methylenetetrahydrofolate reductase	Homo sapiens	163-168
24506394-2	2013	Methylenetetrahydrofolate reductase enzyme (MTHFR) participates in the metabolism of folate with the action of vitamins B6 and B12.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	44-49
24301776-0	2013	Impact of MTHFR polymorphisms on methylation of MGMT in glioma patients from Northeast China with different folate levels.	Folic Acid	108-114	O-6-methylguanine-DNA methyltransferase	Homo sapiens	48-52
24301776-3	2013	As a key enzyme during folate metabolism, polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR) may regulate folate end-products.	Folic Acid	23-29	methylenetetrahydrofolate reductase	Homo sapiens	59-99
24301776-3	2013	As a key enzyme during folate metabolism, polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR) may regulate folate end-products.	Folic Acid	23-29	methylenetetrahydrofolate reductase	Homo sapiens	101-106
24301776-3	2013	As a key enzyme during folate metabolism, polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR) may regulate folate end-products.	Folic Acid	83-89	methylenetetrahydrofolate reductase	Homo sapiens	101-106
24301776-4	2013	We investigated the effect of typical polymorphisms of MTHFR (C677T and A1298C) on MGMT methylation based on different serum folate levels in patients with glioma from Northeast China.	Folic Acid	125-131	methylenetetrahydrofolate reductase	Homo sapiens	55-60
24301776-11	2013	When grouped by the median or biological reference value of serum folate, only homozygotes for C677T with low levels of folate were significantly associated with decreased methylation of MGMT (median, P &lt; 0.001; biological reference value, P = 0.036).	Folic Acid	66-72	O-6-methylguanine-DNA methyltransferase	Homo sapiens	187-191
24301776-11	2013	When grouped by the median or biological reference value of serum folate, only homozygotes for C677T with low levels of folate were significantly associated with decreased methylation of MGMT (median, P &lt; 0.001; biological reference value, P = 0.036).	Folic Acid	120-126	O-6-methylguanine-DNA methyltransferase	Homo sapiens	187-191
24301776-12	2013	These data suggest that, in combination with a negative folate balance in glioma patients, T/T genotypes in MTHFR C677T may be associated with MGMT demethylation.	Folic Acid	56-62	methylenetetrahydrofolate reductase	Homo sapiens	108-113
24301776-12	2013	These data suggest that, in combination with a negative folate balance in glioma patients, T/T genotypes in MTHFR C677T may be associated with MGMT demethylation.	Folic Acid	56-62	O-6-methylguanine-DNA methyltransferase	Homo sapiens	143-147
23806361-1	2013	Folate transporters, including the reduced folate carrier and the proton-coupled folate transporter, encoded by Slc19a1 and Slc46a1 genes respectively, play important roles in the transport of folate across biological membranes given the hydrophilic nature of folates.	Folic Acid	81-87	solute carrier family 19 member 1	Gallus gallus	112-119
23806361-1	2013	Folate transporters, including the reduced folate carrier and the proton-coupled folate transporter, encoded by Slc19a1 and Slc46a1 genes respectively, play important roles in the transport of folate across biological membranes given the hydrophilic nature of folates.	Folic Acid	260-267	solute carrier family 19 member 1	Gallus gallus	112-119
23806361-10	2013	Moreover, the expression of Slc19a1 and Slc46a1 transcripts in the cecum provides evidence of the potential for cecally derived folate to contribute to the folate status of the host.	Folic Acid	128-134	solute carrier family 19 member 1	Gallus gallus	28-35
23806361-10	2013	Moreover, the expression of Slc19a1 and Slc46a1 transcripts in the cecum provides evidence of the potential for cecally derived folate to contribute to the folate status of the host.	Folic Acid	156-162	solute carrier family 19 member 1	Gallus gallus	28-35
23653228-8	2013	Our study indicated that the MTHFR C677T polymorphism contributes to increased ASD risk, and periconceptional folic acid may reduce ASD risk in those with MTHFR 677C&gt;T polymorphism.	Folic Acid	110-120	methylenetetrahydrofolate reductase	Homo sapiens	155-160
23904512-2	2013	Folates are generally taken up into cells by specific transporters, mainly the reduced folate carrier RFC1 (SLC19A1 protein) and the high-affinity folate receptors FOLR1 and FOLR2.	Folic Acid	0-7	solute carrier family 19 (folate transporter), member 1	Mus musculus	108-115
23904512-2	2013	Folates are generally taken up into cells by specific transporters, mainly the reduced folate carrier RFC1 (SLC19A1 protein) and the high-affinity folate receptors FOLR1 and FOLR2.	Folic Acid	87-93	solute carrier family 19 (folate transporter), member 1	Mus musculus	108-115
23836537-1	2013	The metabolic enzyme for folate, Aldh1L1, has been shown to be expressed robustly in astrocytes of the brain.	Folic Acid	25-31	aldehyde dehydrogenase 1 family, member L1	Mus musculus	33-40
23424995-8	2013	KEY RESULTS: Folate up-regulated p21/p27 through a Src/ERK-dependent mechanism that accounted for its anti-proliferative effects on RASMC.	Folic Acid	13-19	KRAS proto-oncogene, GTPase	Rattus norvegicus	33-36
23424995-8	2013	KEY RESULTS: Folate up-regulated p21/p27 through a Src/ERK-dependent mechanism that accounted for its anti-proliferative effects on RASMC.	Folic Acid	13-19	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	51-54
23424995-9	2013	Folate protected RASMC from the effects of homocysteine by reducing AKT1, focal adhesion kinase (FAK), paxillin, and p190RhoGAP activation/phosphorylation, along with cytosolic levels of p21 and p27, and increasing RhoA activation.	Folic Acid	0-6	KRAS proto-oncogene, GTPase	Rattus norvegicus	187-190
23424995-9	2013	Folate protected RASMC from the effects of homocysteine by reducing AKT1, focal adhesion kinase (FAK), paxillin, and p190RhoGAP activation/phosphorylation, along with cytosolic levels of p21 and p27, and increasing RhoA activation.	Folic Acid	0-6	ras homolog family member A	Rattus norvegicus	215-219
23424995-13	2013	In RASMC overexpressing constitutively active RhoA, activation of RhoA mediated the anti-migratory effects of folate.	Folic Acid	110-116	ras homolog family member A	Rattus norvegicus	46-50
23424995-13	2013	In RASMC overexpressing constitutively active RhoA, activation of RhoA mediated the anti-migratory effects of folate.	Folic Acid	110-116	ras homolog family member A	Rattus norvegicus	66-70
23876493-9	2013	CONCLUSIONS: The MTHFR C677T polymorphism, which directly influences plasma folate levels, is not associated with CHD risk.	Folic Acid	76-82	methylenetetrahydrofolate reductase	Homo sapiens	17-22
23964315-8	2013	Positive correlations were found between the hepatic folate content and global DNA methylation and protein expressions of FRalpha, IGF-2 and IGF-1R, whereas an inverse correlation was found between hepatic folate content and plasma homocysteine level in the 3-week-old rat pup.	Folic Acid	53-59	insulin-like growth factor 2	Rattus norvegicus	131-136
23500531-8	2013	Moreover, they are important for the regulation of folate metabolites by using tetrahydrofolate as cosubstrate in choline degradation, reduction of N-5.10-methylenetetrahydrofolate to N-5-methyltetrahydrofolate and maintenance of the catalytically competent form of methionine synthase.	Folic Acid	51-57	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	266-285
23857226-0	2013	The reduced folate carrier (RFC-1) 80A&gt;G polymorphism and maternal risk of having a child with Down syndrome: a meta-analysis.	Folic Acid	12-18	replication factor C subunit 1	Homo sapiens	28-33
23857226-1	2013	A common polymorphism (c.80A&gt;G) in the gene coding for the reduced folate carrier (SLC19A1, commonly known as RFC-1) has been associated with maternal risk of the birth of a child with Down Syndrome (DS), but results are controversial.	Folic Acid	70-76	replication factor C subunit 1	Homo sapiens	113-118
23935743-0	2013	Effect of folic acid and vitamin B12 on the expression of PPARgamma, caspase-3 and caspase-8 mRNA in the abdominal aortas of rats with hyperlipidemia.	Folic Acid	10-20	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	58-67
23935743-0	2013	Effect of folic acid and vitamin B12 on the expression of PPARgamma, caspase-3 and caspase-8 mRNA in the abdominal aortas of rats with hyperlipidemia.	Folic Acid	10-20	caspase 8	Rattus norvegicus	83-92
23700346-2	2013	Here we investigated the role of serine hydroxymethyltransferase 1 (SHMT1), a folate-dependent enzyme regulating de novo thymidylate biosynthesis, in influencing neuronal and cognitive function in the adult mouse.	Folic Acid	78-84	serine hydroxymethyltransferase 1 (soluble)	Mus musculus	33-66
23700346-2	2013	Here we investigated the role of serine hydroxymethyltransferase 1 (SHMT1), a folate-dependent enzyme regulating de novo thymidylate biosynthesis, in influencing neuronal and cognitive function in the adult mouse.	Folic Acid	78-84	serine hydroxymethyltransferase 1 (soluble)	Mus musculus	68-73
23692062-1	2013	OBJECTIVES: To assess the associations of folate, homocysteine and vitamin B12 levels of children at birth and their methylenetetrahydrofolate reductase (MTHFR) variants with asthma and eczema in childhood.	Folic Acid	42-48	methylenetetrahydrofolate reductase	Homo sapiens	117-152
23692062-8	2013	In children carrying C677T mutations in MTHFR, higher folate levels were associated with an increased risk of eczema (repeated eczema until 4 years: OR 1.40 (95% CI 1.09-1.80) (SD change) P-interaction = 0.003, eczema ever at 6 years: OR 1.41 (0.97-2.03) P-interaction = 0.011).	Folic Acid	54-60	methylenetetrahydrofolate reductase	Homo sapiens	40-45
23434700-2	2013	To engineer multifunctional nanomedicines for simultaneous imaging and therapy of cancer cells, in the current study, we synthesized tamoxifen (TMX) loaded folic acid (FA) armed MNPs to target the folate receptor (FR) positive cancer cells.	Folic Acid	156-166	thioredoxin related transmembrane protein 1	Homo sapiens	144-147
23298970-0	2013	Elderly women: homocysteine reduction by short-term folic acid supplementation resulting in increased glucose concentrations and affecting lipid metabolism (C677T MTHFR polymorphism).	Folic Acid	52-62	methylenetetrahydrofolate reductase	Homo sapiens	163-168
23819405-7	2013	A key enzyme in folate metabolism is methylenetetrahydrofolate reductase (MTHFR - methylenetetrahydrofolate reductase), and 677C&gt;T polymorphism of MTHFR gene is connected with lower enzymatic activity In several researches it was indicated that 677C&gt;T MTHFR polymorphism is an independent factor influencing homocysteine concentration in serum, and also folate concentration in serum and red blood cells.	Folic Acid	56-62	methylenetetrahydrofolate reductase	Homo sapiens	82-117
23819405-10	2013	Women carriers of 677TT or 677CT MTHFR genotypes are exposed on folate metabolism disturbances and on the consequences of incorrect folate process during pregnancy Nowadays in this group of women folic acid supplementation is widely recommended.	Folic Acid	64-70	methylenetetrahydrofolate reductase	Homo sapiens	33-38
23819405-10	2013	Women carriers of 677TT or 677CT MTHFR genotypes are exposed on folate metabolism disturbances and on the consequences of incorrect folate process during pregnancy Nowadays in this group of women folic acid supplementation is widely recommended.	Folic Acid	132-138	methylenetetrahydrofolate reductase	Homo sapiens	33-38
23819405-10	2013	Women carriers of 677TT or 677CT MTHFR genotypes are exposed on folate metabolism disturbances and on the consequences of incorrect folate process during pregnancy Nowadays in this group of women folic acid supplementation is widely recommended.	Folic Acid	196-206	methylenetetrahydrofolate reductase	Homo sapiens	33-38
23295071-0	2013	Folate metabolism gene polymorphisms MTHFR C677T and A1298C and risk for Down syndrome offspring: a meta-analysis.	Folic Acid	0-6	methylenetetrahydrofolate reductase	Homo sapiens	37-42
23229416-0	2013	Effects of paternal folate deficiency on the expression of insulin-like growth factor-2 and global DNA methylation in the fetal brain.	Folic Acid	20-26	insulin-like growth factor 2	Rattus norvegicus	59-87
23229416-5	2013	There were positive correlations between paternal liver and testis folate content and the percentage of 5-mC and IGF-2 expression in the fetal whole brain.	Folic Acid	67-73	insulin-like growth factor 2	Rattus norvegicus	113-118
23229416-6	2013	CONCLUSION: Our results on the folate content, the percentage of 5-mC, and IGF-2 expression in the fetal whole brain show that paternal folate deficiency at mating can influence fetal brain DNA methylation and IGF-2 expression despite an adequate maternal folate status during the gestational period.	Folic Acid	136-142	insulin-like growth factor 2	Rattus norvegicus	75-80
23229416-6	2013	CONCLUSION: Our results on the folate content, the percentage of 5-mC, and IGF-2 expression in the fetal whole brain show that paternal folate deficiency at mating can influence fetal brain DNA methylation and IGF-2 expression despite an adequate maternal folate status during the gestational period.	Folic Acid	136-142	insulin-like growth factor 2	Rattus norvegicus	210-215
23463647-5	2013	At weaning, maternal folic acid supplementation significantly decreased global (p &lt; 0.001) and site-specific DNA methylation of the Ppar-gamma, ER-alpha, p53, and Apc genes (p &lt; 0.05) in the liver.	Folic Acid	21-31	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	135-145
23463647-7	2013	At 14 weeks of age, both maternal and postweaning folic acid supplementation significantly increased DNA methylation of the Ppar-gamma, p53, and p16 genes (p &lt; 0.05) whereas only postweaning FA supplementation significantly increased DNA methylation of the ER-alpha and Apc genes (p &lt; 0.05).	Folic Acid	50-60	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	124-134
23463647-7	2013	At 14 weeks of age, both maternal and postweaning folic acid supplementation significantly increased DNA methylation of the Ppar-gamma, p53, and p16 genes (p &lt; 0.05) whereas only postweaning FA supplementation significantly increased DNA methylation of the ER-alpha and Apc genes (p &lt; 0.05).	Folic Acid	50-60	cyclin-dependent kinase inhibitor 2A	Rattus norvegicus	145-148
24353609-2	2013	Previous studies regarding the association of folate intake and Methylenetetrahydrofolate reductase C677T polymorphism with ESCC was conflicting.	Folic Acid	46-52	methylenetetrahydrofolate reductase	Homo sapiens	64-99
24353609-9	2013	CONCLUSIONS: Our meta-analysis indicated the folate intake and MTHFR 677CT/TT are associated with the risk of ESCC, and folate showed a significant interaction with polymorphism of MTHFR C677T.	Folic Acid	120-126	methylenetetrahydrofolate reductase	Homo sapiens	181-186
23276705-2	2013	Methylene tetrahydrofolate reductase (MTHFR) is a pivotal enzyme in folate metabolism.	Folic Acid	20-26	methylenetetrahydrofolate reductase	Homo sapiens	38-43
22527288-9	2013	Folate variants with the strongest independent effect on folate status were C677T-MTHFR (p = 0.0004) and G1793A-MTHFR (p = 0.0173).	Folic Acid	0-6	methylenetetrahydrofolate reductase	Homo sapiens	82-87
22527288-9	2013	Folate variants with the strongest independent effect on folate status were C677T-MTHFR (p = 0.0004) and G1793A-MTHFR (p = 0.0173).	Folic Acid	0-6	methylenetetrahydrofolate reductase	Homo sapiens	112-117
22527288-9	2013	Folate variants with the strongest independent effect on folate status were C677T-MTHFR (p = 0.0004) and G1793A-MTHFR (p = 0.0173).	Folic Acid	57-63	methylenetetrahydrofolate reductase	Homo sapiens	82-87
22527288-9	2013	Folate variants with the strongest independent effect on folate status were C677T-MTHFR (p = 0.0004) and G1793A-MTHFR (p = 0.0173).	Folic Acid	57-63	methylenetetrahydrofolate reductase	Homo sapiens	112-117
23329275-1	2013	Methylenetetrahydrofolate reductase (MTHFR) enzyme plays an important role in folate metabolism and MTHFR polymorphisms have been suggested to be associated with risk of various cancers.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
23329275-1	2013	Methylenetetrahydrofolate reductase (MTHFR) enzyme plays an important role in folate metabolism and MTHFR polymorphisms have been suggested to be associated with risk of various cancers.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	100-105
23157378-2	2013	Simultaneous supplement of folate and vitamin B12 partially restored the plasma homocysteine level and attenuated tau hyperphosphorylation, Abeta accumulation and memory impairments induced by Hhcy.	Folic Acid	27-33	amyloid beta precursor protein	Rattus norvegicus	140-145
23751476-0	2013	[Effect of folate in modulating the expression of DNA methyltransferase 1 and methyl-CpG-binding protein 2 in cervical cancer cell lines].	Folic Acid	11-17	DNA methyltransferase 1	Homo sapiens	50-73
23751476-1	2013	OBJECTIVE: To explore the effects of folate on the expression of DNA methyltransferase 1 (DNMT1) and methyl-CpG-binding protein 2 (MeCP2) in cervical cancer cell lines.	Folic Acid	37-43	DNA methyltransferase 1	Homo sapiens	65-88
23751476-1	2013	OBJECTIVE: To explore the effects of folate on the expression of DNA methyltransferase 1 (DNMT1) and methyl-CpG-binding protein 2 (MeCP2) in cervical cancer cell lines.	Folic Acid	37-43	DNA methyltransferase 1	Homo sapiens	90-95
23751476-7	2013	When at the same levels of folate, the expression of DNMT1 protein or mRNA was higher in Caski cell than in C33A cell.	Folic Acid	27-33	DNA methyltransferase 1	Homo sapiens	53-58
23751476-9	2013	CONCLUSION: Our finding indicated that adequate folate could effectively inhibit the proliferation of cervical cancer cells and facilitate their apoptosis in vitro, thus would reverse the aberration protein expression of DNMT1 and MeCP2.	Folic Acid	48-54	DNA methyltransferase 1	Homo sapiens	221-226
24051386-2	2013	The aim of the present study was to investigate associations between folate intake, red blood cell (RBC) folate, total homocysteine (tHcy) and the MTHFR 677T allele.	Folic Acid	69-75	methylenetetrahydrofolate reductase	Homo sapiens	147-152
23803097-1	2013	Methylenetetrahydrofolate reductase (MTHFR) plays a central role in folate metabolism.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
23273201-1	2012	MTHFR is a key enzyme in folate metabolism that catalyzes the conversion of 5, 10&amp;mdash;methlenetetrahydrofolate (5, 10&amp;mdash; methylene THF) to 5&amp;mdash;methyltetrahydrofolate (5&amp;mdash;methyl THF), a predominant circulatory form of folate and methyl donor for the remethylation of homocysteine to methionine.	Folic Acid	110-116	methylenetetrahydrofolate reductase	Homo sapiens	0-5
23273201-13	2012	The T allele frequency of MTHFR (C667T) was found to be a significant risk factor for chronic pancreatitis playing a crucial role in altered folate metabolsim.	Folic Acid	141-147	methylenetetrahydrofolate reductase	Homo sapiens	26-31
23256224-3	2004	Two site-specific carboxypeptidase activities have been assigned to PSMA: N-acetylated alpha-linked acidic dipeptidase, which hydrolyzes the neuropeptide N-acetyl-aspartyl-glutamate (NAAG) in the brain to regulate release of neurotransmitters, and folate hydrolase activity, which is characterized by the cleavage of terminal glutamates from poly- and gamma-glutamated folates, which play a role in the cellular uptake of dietary folate (2).	Folic Acid	248-254	folate hydrolase 1B (pseudogene)	Homo sapiens	74-118
22975209-1	2012	The reduced folate carrier (RFC1) plays a crucial role in mediating folate delivery into a variety of cells.	Folic Acid	12-18	replication factor C subunit 1	Homo sapiens	28-32
22975209-1	2012	The reduced folate carrier (RFC1) plays a crucial role in mediating folate delivery into a variety of cells.	Folic Acid	68-74	replication factor C subunit 1	Homo sapiens	28-32
23363965-10	2012	The results showed that the serum folate levels were descended, and the expression levels of DNMT1 protein (chi(2)(tend) = 50.80, P &lt; 0.05) and mRNA (chi(2)(tend) = 17.63, P &lt; 0.05) were increased steadily with the severity of the cervix lesions.	Folic Acid	34-40	DNA methyltransferase 1	Homo sapiens	93-98
23363965-15	2012	At folate concentration of 1000 microg/ml, the expression of DNMT1 protein or mRNA was higher in Caski cell than in C33A cell (t values were -4.22 and 3.50, all P values &lt; 0.05).	Folic Acid	3-9	DNA methyltransferase 1	Homo sapiens	61-66
23363965-17	2012	Sufficient folate is able to effectively inhibit the growth of cervical cancer cells in vitro, and would counteract transcriptional and posttranscriptional aberration of DNMT1.	Folic Acid	11-17	DNA methyltransferase 1	Homo sapiens	170-175
23146986-1	2012	Methylene tetrahydrofolate reductase (MTHFR) is an enzyme involved in the metabolism of homocysteine to methionine, and folic acid is an essential cofactor.	Folic Acid	120-130	methylenetetrahydrofolate reductase	Homo sapiens	0-36
23146986-1	2012	Methylene tetrahydrofolate reductase (MTHFR) is an enzyme involved in the metabolism of homocysteine to methionine, and folic acid is an essential cofactor.	Folic Acid	120-130	methylenetetrahydrofolate reductase	Homo sapiens	38-43
23095111-3	2012	Several studies have suggested that polymorphisms in methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, reduced folate carrier (RFC1) G80A, and ABCB1 C3435T, could be related to methotrexate toxicity.	Folic Acid	72-78	methylenetetrahydrofolate reductase	Homo sapiens	90-95
22847888-1	2012	Methylenetetrahydrofolate reductase (MTHFR), an important enzyme in folate metabolism, is thought to be involved in the development of nonsyndromic orofacial clefts (NSOC).	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
22869041-12	2012	Conversely, among women with high serum folate levels (n = 53), DNA methylation was positively associated with several immune markers (CD4/CD8 ratio, NK1656/lymphocytes and IgA).	Folic Acid	40-46	CD8a molecule	Homo sapiens	139-142
22912935-10	2012	Increased risk was also apparent for average weekly alcohol consumption when accounting for the multiplicative interaction between folate intake and MTHFR C677T genotype (OR = 3.22; 95% CI: 1.36-7.59).	Folic Acid	131-137	methylenetetrahydrofolate reductase	Homo sapiens	149-154
22652272-3	2012	This study assesses the relation between homocysteine concentrations and MTHFR gene polymorphisms at two common alleles (C677T (rs1801133) and A1298C (rs1801131)) as well as other predictors of homocysteine (folate, vitamin B(12), body mass index (BMI), age, and gender) in a group of healthy Lebanese: 109 males and 124 females aged 17-55years.	Folic Acid	208-214	methylenetetrahydrofolate reductase	Homo sapiens	73-78
22441130-2	2012	The enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR), involved in folate metabolism, plays a crucial role in cells because folate availability is important for DNA integrity.	Folic Acid	35-41	methylenetetrahydrofolate reductase	Homo sapiens	53-58
22441130-2	2012	The enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR), involved in folate metabolism, plays a crucial role in cells because folate availability is important for DNA integrity.	Folic Acid	73-79	methylenetetrahydrofolate reductase	Homo sapiens	11-51
22441130-2	2012	The enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR), involved in folate metabolism, plays a crucial role in cells because folate availability is important for DNA integrity.	Folic Acid	73-79	methylenetetrahydrofolate reductase	Homo sapiens	53-58
22132838-1	2012	Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme regulating the intracellular folate metabolism which plays an important role in carcinogenesis through DNA methylation and nucleotide synthesis.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
22946297-1	2012	The work is dedicated to creation of the mathematical model of folate-dependent one-carbon unit metabolism (FOCM) and study of its function in human placenta under homocysteine load and the most common mutations in the genes of methylenetetrahydrofolate reductase (MTHFR) and cystathionine beta-synthase (CBS).	Folic Acid	63-69	methylenetetrahydrofolate reductase	Homo sapiens	228-263
22946297-1	2012	The work is dedicated to creation of the mathematical model of folate-dependent one-carbon unit metabolism (FOCM) and study of its function in human placenta under homocysteine load and the most common mutations in the genes of methylenetetrahydrofolate reductase (MTHFR) and cystathionine beta-synthase (CBS).	Folic Acid	63-69	methylenetetrahydrofolate reductase	Homo sapiens	265-270
21489764-1	2012	AIMS: Methylenetetrahydrofolate reductase (MTHFR) plays a crucial role in regulating folate metabolism, which affects DNA synthesis and methylation.	Folic Acid	25-31	methylenetetrahydrofolate reductase	Homo sapiens	43-48
22106923-1	2012	AIMS: Two single nucleotide polymorphisms in the methylene tetrahydrofolate reductase (MTHFR) gene, 677C/T and 1298A/C, encode the thermolabile isoforms of the MTHFR enzyme that adversely affect the folic acid metabolic pathway.	Folic Acid	199-209	methylenetetrahydrofolate reductase	Homo sapiens	49-85
22106923-1	2012	AIMS: Two single nucleotide polymorphisms in the methylene tetrahydrofolate reductase (MTHFR) gene, 677C/T and 1298A/C, encode the thermolabile isoforms of the MTHFR enzyme that adversely affect the folic acid metabolic pathway.	Folic Acid	199-209	methylenetetrahydrofolate reductase	Homo sapiens	87-92
22106923-1	2012	AIMS: Two single nucleotide polymorphisms in the methylene tetrahydrofolate reductase (MTHFR) gene, 677C/T and 1298A/C, encode the thermolabile isoforms of the MTHFR enzyme that adversely affect the folic acid metabolic pathway.	Folic Acid	199-209	methylenetetrahydrofolate reductase	Homo sapiens	160-165
22093367-2	2012	This activity is compromised when vitamin B12 concentration is low because methionine synthase activity is reduced, lowering the concentration of S-adenosyl methionine (SAM) which in turn may diminish DNA methylation and cause folate to become unavailable for the conversion of dUMP to dTMP.	Folic Acid	227-233	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	75-94
22363213-2	2012	When folate levels are low, the TT genotype of the common C677T polymorphism (rs1801133) of the methylene tetrahydrofolate reductase gene (MTHFR) appreciably increases homocysteine levels, so "Mendelian randomization" studies using this variant as an instrumental variable could help test causality.	Folic Acid	5-11	methylenetetrahydrofolate reductase	Homo sapiens	96-137
22363213-2	2012	When folate levels are low, the TT genotype of the common C677T polymorphism (rs1801133) of the methylene tetrahydrofolate reductase gene (MTHFR) appreciably increases homocysteine levels, so "Mendelian randomization" studies using this variant as an instrumental variable could help test causality.	Folic Acid	5-11	methylenetetrahydrofolate reductase	Homo sapiens	139-144
22422209-5	2012	Pathways of cobalamin and folate metabolism intersect at one site, methionine synthase.	Folic Acid	26-32	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	67-86
21772318-0	2012	Folic acid supplementation during pregnancy may protect against depression 21 months after pregnancy, an effect modified by MTHFR C677T genotype.	Folic Acid	0-10	methylenetetrahydrofolate reductase	Homo sapiens	124-129
21772318-3	2012	We also tested whether there was a main effect of methylenetetrahydrofolate reductase (MTHFR) C677T genotype (which influences folate metabolism and intracellular levels of folate metabolites and homocysteine) on change in depression scores, and carried out our analysis of folic acid supplementation and depression stratifying by genotype.	Folic Acid	69-75	methylenetetrahydrofolate reductase	Homo sapiens	87-92
21772318-3	2012	We also tested whether there was a main effect of methylenetetrahydrofolate reductase (MTHFR) C677T genotype (which influences folate metabolism and intracellular levels of folate metabolites and homocysteine) on change in depression scores, and carried out our analysis of folic acid supplementation and depression stratifying by genotype.	Folic Acid	127-133	methylenetetrahydrofolate reductase	Homo sapiens	87-92
22848173-6	2012	METHODS AND RESULTS: Intravenous administration of folate-targeted, paclitaxel-loaded micelles was demonstrated to be more efficient in inhibiting subcutaneous xenograft tumors and extending the survival rate of tumor-bearing nude mice than free paclitaxel and plain paclitaxel micelles at an equivalent paclitaxel dose of 20 mg/kg, which was further backed up by flow cytometry, TUNEL, and expression of apoptosis-related proteins, including Bax, Bcl2, and caspase 3 in this study.	Folic Acid	51-57	BCL2-associated X protein	Mus musculus	443-446
22848173-6	2012	METHODS AND RESULTS: Intravenous administration of folate-targeted, paclitaxel-loaded micelles was demonstrated to be more efficient in inhibiting subcutaneous xenograft tumors and extending the survival rate of tumor-bearing nude mice than free paclitaxel and plain paclitaxel micelles at an equivalent paclitaxel dose of 20 mg/kg, which was further backed up by flow cytometry, TUNEL, and expression of apoptosis-related proteins, including Bax, Bcl2, and caspase 3 in this study.	Folic Acid	51-57	caspase 3	Mus musculus	458-467
22057276-1	2011	Uracil accumulates in DNA as a result of impaired folate-dependent de novo thymidylate biosynthesis, a pathway composed of the enzymes serine hydroxymethyltransferase (SHMT), thymidylate synthase (TYMS), and dihydrofolate reductase.	Folic Acid	50-56	serine hydroxymethyltransferase 1 (soluble)	Mus musculus	135-166
22057276-1	2011	Uracil accumulates in DNA as a result of impaired folate-dependent de novo thymidylate biosynthesis, a pathway composed of the enzymes serine hydroxymethyltransferase (SHMT), thymidylate synthase (TYMS), and dihydrofolate reductase.	Folic Acid	50-56	serine hydroxymethyltransferase 1 (soluble)	Mus musculus	168-172
22057276-1	2011	Uracil accumulates in DNA as a result of impaired folate-dependent de novo thymidylate biosynthesis, a pathway composed of the enzymes serine hydroxymethyltransferase (SHMT), thymidylate synthase (TYMS), and dihydrofolate reductase.	Folic Acid	50-56	thymidylate synthase	Mus musculus	175-195
22057276-1	2011	Uracil accumulates in DNA as a result of impaired folate-dependent de novo thymidylate biosynthesis, a pathway composed of the enzymes serine hydroxymethyltransferase (SHMT), thymidylate synthase (TYMS), and dihydrofolate reductase.	Folic Acid	50-56	thymidylate synthase	Mus musculus	197-201
22057276-5	2011	Overexpression of SHMT1 in cell cultures inhibits folate-dependent homocysteine remethylation and enhances thymidylate biosynthesis.	Folic Acid	50-56	serine hydroxymethyltransferase 1 (soluble)	Mus musculus	18-23
22097960-1	2011	Human methionine synthase reductase (MSR), a diflavin oxidoreductase, plays a vital role in methionine and folate metabolism by sustaining methionine synthase (MS) activity.	Folic Acid	107-113	thioredoxin reductase 1	Homo sapiens	54-68
22097960-1	2011	Human methionine synthase reductase (MSR), a diflavin oxidoreductase, plays a vital role in methionine and folate metabolism by sustaining methionine synthase (MS) activity.	Folic Acid	107-113	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	6-25
22194208-1	2011	Methylenetetrahydrofolate reductase (MTHFR) plays an  important role in folate metabolism and is involved in DNA synthesis, DNA  repair and DNA methylation.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
22194208-9	2011	MTHFR 677TT+CT genotypes had a significantly lower plasma folate  concentration than those with the MTHFR 677CC genotype.	Folic Acid	58-64	methylenetetrahydrofolate reductase	Homo sapiens	0-5
22194208-10	2011	MTHFR 1298AC+CC  genotypes had a lower plasma folate concentration than those with the MTHFR 1298AA  genotype (P &lt; 0.05).	Folic Acid	46-52	methylenetetrahydrofolate reductase	Homo sapiens	0-5
22194208-14	2011	We conclude that plasma folate level is influenced by MTHFR genotypes.	Folic Acid	24-30	methylenetetrahydrofolate reductase	Homo sapiens	54-59
21793799-1	2011	BACKGROUND: As a key enzyme in folate metabolism, 5,10- methylenetetrahydrofolate reductase (MTHFR) regulates the homeostasis between DNA synthesis and methylation.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	56-91
21793799-1	2011	BACKGROUND: As a key enzyme in folate metabolism, 5,10- methylenetetrahydrofolate reductase (MTHFR) regulates the homeostasis between DNA synthesis and methylation.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	93-98
21612398-3	2011	Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme in folate metabolism and two of its functional polymorphisms, MTHFR C677T and MTHFR A1298C, might be associated with NSOC susceptibility.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
21612398-3	2011	Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme in folate metabolism and two of its functional polymorphisms, MTHFR C677T and MTHFR A1298C, might be associated with NSOC susceptibility.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	129-134
21612398-3	2011	Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme in folate metabolism and two of its functional polymorphisms, MTHFR C677T and MTHFR A1298C, might be associated with NSOC susceptibility.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	129-134
22108397-3	2011	However, some individuals have a genetic deficiency in the methylene tetrahydrofolate reductase (MTHFR) gene that limits conversion of folic acid to its biologically active form, L-methylfolate.	Folic Acid	135-145	methylenetetrahydrofolate reductase	Homo sapiens	59-95
22108397-3	2011	However, some individuals have a genetic deficiency in the methylene tetrahydrofolate reductase (MTHFR) gene that limits conversion of folic acid to its biologically active form, L-methylfolate.	Folic Acid	135-145	methylenetetrahydrofolate reductase	Homo sapiens	97-102
21967996-0	2011	Association between MTHFR C677T genotype and circulating folate levels irrespective of folate intake: data from the IMMIDIET Project.	Folic Acid	57-63	methylenetetrahydrofolate reductase	Homo sapiens	20-25
21955385-1	2011	Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the metabolism of folate, whose role in bipolar disorder is controversial.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
21868559-1	2011	BACKGROUND: The aim of this study was to explore the effect in stage III colorectal cancer of functional gene polymorphisms methylenetetrahydrofolate reductase (MTHFR C677T) and methionine synthase (A2756G), in the folate metabolism on outcome and risk of toxicity for adjuvant chemotherapy.	Folic Acid	143-149	methylenetetrahydrofolate reductase	Homo sapiens	161-166
21752986-4	2011	We also examined the interaction of these folate concentrations with polymorphisms in two enzymes [methylene tetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS)] in relation to the biochemical products.	Folic Acid	42-48	methylenetetrahydrofolate reductase	Homo sapiens	99-135
21752986-4	2011	We also examined the interaction of these folate concentrations with polymorphisms in two enzymes [methylene tetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS)] in relation to the biochemical products.	Folic Acid	42-48	methylenetetrahydrofolate reductase	Homo sapiens	137-142
21752986-7	2011	The relationship between folate concentrations and thymidylate synthesis was modified by genetic variation in TS but less so by variation in MTHFR.	Folic Acid	25-31	methylenetetrahydrofolate reductase	Homo sapiens	141-146
21607713-6	2011	Patients with MTHFR TT677 genotype showed higher plasma Hcy levels than controls, even after adjustment for folate levels (P < 0.05).	Folic Acid	108-114	methylenetetrahydrofolate reductase	Homo sapiens	14-19
21803414-0	2011	Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials.	Folic Acid	42-48	methylenetetrahydrofolate reductase	Homo sapiens	76-81
21803414-4	2011	We aimed to reduce the effect of small-study bias and investigate whether folate status modifies the association between MTHFR 677C T and stroke in a genetic analysis and meta-analysis of randomised controlled trials.	Folic Acid	74-80	methylenetetrahydrofolate reductase	Homo sapiens	121-126
21803414-7	2011	FINDINGS: The effect of the MTHFR 677C T variant on homocysteine concentration was larger in low folate regions (Asia; difference between individuals with TT versus CC genotype, 3 12 mumol/L, 95% CI 2 23 to 4 01) than in areas with folate fortification (America, Australia, and New Zealand, high; 0 13 mumol/L, -0 85 to 1 11).	Folic Acid	97-103	methylenetetrahydrofolate reductase	Homo sapiens	28-33
21803414-7	2011	FINDINGS: The effect of the MTHFR 677C T variant on homocysteine concentration was larger in low folate regions (Asia; difference between individuals with TT versus CC genotype, 3 12 mumol/L, 95% CI 2 23 to 4 01) than in areas with folate fortification (America, Australia, and New Zealand, high; 0 13 mumol/L, -0 85 to 1 11).	Folic Acid	232-238	methylenetetrahydrofolate reductase	Homo sapiens	28-33
21803414-13	2011	Further large-scale genetic studies of the association between MTHFR 677C T and stroke in low folate settings are needed to distinguish effect modification by folate from small-study bias.	Folic Acid	94-100	methylenetetrahydrofolate reductase	Homo sapiens	63-68
21803414-13	2011	Further large-scale genetic studies of the association between MTHFR 677C T and stroke in low folate settings are needed to distinguish effect modification by folate from small-study bias.	Folic Acid	159-165	methylenetetrahydrofolate reductase	Homo sapiens	63-68
21108044-6	2011	Real-time PCR indicated that gene expression of MAT1A, MAT2A and DNMT1 were lower in IUGR piglets but could be elevated by maternal folic acid supplementation.	Folic Acid	132-142	DNA methyltransferase 1	Homo sapiens	65-70
21108044-7	2011	Transcript expression levels of PPARgamma, GR and AOX were higher in IUGR piglets, but were decreased to the level of normal piglets by maternal folic acid supplementation.	Folic Acid	145-155	acyl-CoA oxidase 1	Homo sapiens	50-53
20850942-8	2011	Our results show that we should be aware of possible inborn errors of folate metabolism such as MTHFR deficiency, in infants with unexplained developmental delay manifesting rapidly progressive polyneuropathy.	Folic Acid	70-76	methylenetetrahydrofolate reductase	Homo sapiens	96-101
20608880-1	2011	The goal of this study is to determine whether cardiovascular risk and the methylenetetrahydrofolate reductase 677 C-&gt;T polymorphism (MTHFR), an enzyme involved in folate metabolism and in epigenetics, are linked in morbidly obese non-diabetic adolescents.	Folic Acid	94-100	methylenetetrahydrofolate reductase	Homo sapiens	137-142
21634076-0	2004	(67/68)Ga-Tetraazacyclododecane-N,N",N"",N"""-tetraacetic acid-1,2-diaminoethane-gamma-folate Folic acid (folate) is a water-soluble B vitamin (1) that is essential for methylation and DNA synthesis.	Folic Acid	94-104	mediator complex subunit 25	Homo sapiens	58-64
21634076-0	2004	(67/68)Ga-Tetraazacyclododecane-N,N",N"",N"""-tetraacetic acid-1,2-diaminoethane-gamma-folate Folic acid (folate) is a water-soluble B vitamin (1) that is essential for methylation and DNA synthesis.	Folic Acid	87-93	mediator complex subunit 25	Homo sapiens	58-64
21346251-0	2011	A mouse model of hereditary folate malabsorption: deletion of the PCFT gene leads to systemic folate deficiency.	Folic Acid	28-34	solute carrier family 46, member 1	Mus musculus	66-70
20978370-9	2011	Overall, folate was associated with increased methylation levels of RASSF1A and MTHFR and methionine was associated with decreased methylation levels of RASSF1A.	Folic Acid	9-15	Ras association domain family member 1	Homo sapiens	68-75
20978370-9	2011	Overall, folate was associated with increased methylation levels of RASSF1A and MTHFR and methionine was associated with decreased methylation levels of RASSF1A.	Folic Acid	9-15	methylenetetrahydrofolate reductase	Homo sapiens	80-85
20978370-9	2011	Overall, folate was associated with increased methylation levels of RASSF1A and MTHFR and methionine was associated with decreased methylation levels of RASSF1A.	Folic Acid	9-15	Ras association domain family member 1	Homo sapiens	153-160
21070756-7	2011	CONCLUSION: Our findings provide support for the synergistic effects of polymorphisms in the folate metabolic pathway genes in PD susceptibility; the increased PD risk would be more significant in carriers with the polymorphisms of MTHFR, MTR, and MTRR genes.	Folic Acid	93-99	methylenetetrahydrofolate reductase	Homo sapiens	232-237
22292644-2	2011	We here evaluated associations of the MTHFR C677T polymorphism and folate intake with esophageal cancer.	Folic Acid	67-73	methylenetetrahydrofolate reductase	Homo sapiens	38-43
20799032-0	2011	Development of new folate-based PET radiotracers: preclinical evaluation of 68Ga-DOTA-folate conjugates.	Folic Acid	19-25	thyroid stimulating hormone receptor	Mus musculus	32-35
20799032-2	2011	A (68)Ga-folate-based radiopharmaceutical would be of great interest, combining the advantages of PET technology and the availability of (68)Ga from a generator.	Folic Acid	9-15	thyroid stimulating hormone receptor	Mus musculus	98-101
22432562-7	2010	Neither oral cancer cell line harbored the common C677T DNA polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene, which might reduce folate bioavailability.	Folic Acid	99-105	methylenetetrahydrofolate reductase	Homo sapiens	117-122
21125200-12	2010	In addition, the C677T-MTHFR association adds further support to existing findings underscoring the potential role of folate in depression.	Folic Acid	118-124	methylenetetrahydrofolate reductase	Homo sapiens	23-28
20833714-10	2010	Thus, one of the mechanisms by which folate may rescue the Sp(-/-) phenotype is by increasing the expression of KDM6B, which in turn decreases H3K27 methylation marks on Hes1 and Neurog2 promoters thereby affecting gene transcription.	Folic Acid	37-43	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	112-117
20456312-4	2010	The examinations included spirometry, measurements of serum folate and B12, specific IgE to inhalant allergens, total IgE, and genotyping of the MTHFR-C677T polymorphism - a genetic marker of impaired folate metabolism.	Folic Acid	201-207	methylenetetrahydrofolate reductase	Homo sapiens	145-150
20236116-1	2010	Methylenetetrahydrofolate reductase (MTHFR) plays a major role in folate metabolism.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
20552676-2	2010	5,10-Methylenetetrahydrofolate reductase (MTHFR) is a crucial enzyme in folate-mediated one-carbon metabolism and folate deficiency can be associated with psychiatric symptoms.	Folic Acid	24-30	methylenetetrahydrofolate reductase	Homo sapiens	42-47
20941748-1	2010	5,10-Methylenetetrahydrofolate reductase (MTHFR) catalyzes the metabolism of folate and nucleotides, which are essential for DNA synthesis and methylation.	Folic Acid	24-30	methylenetetrahydrofolate reductase	Homo sapiens	42-47
20803414-6	2010	Folic acid supplementation reduced visceral obesity and improved plasma adiponectin levels.	Folic Acid	0-10	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	72-83
21462116-3	2010	Among common genetic variants that reside in genes regulating folate absorptive and metabolic processes, homozygosity for the MTHFR 677C &gt; T variant has consistently been shown to have robust effects on status markers.	Folic Acid	62-68	methylenetetrahydrofolate reductase	Homo sapiens	126-131
20935396-2	2010	The enzyme methylenetetrahydrofolate reductase (MTHFR) catalyses the formation of folate intermediates that are vital for DNA synthesis and methylation reactions.	Folic Acid	30-36	methylenetetrahydrofolate reductase	Homo sapiens	48-53
20935396-3	2010	C677T and A1298C variants of MTHFR result in reduced plasma folate and increase the susceptibility to various multifactorial disorders.	Folic Acid	60-66	methylenetetrahydrofolate reductase	Homo sapiens	29-34
20097536-14	2010	Also, consumption of folate-fortified foods modulates the association of the MTHFR 677C&gt;T polymorphism with tHcy, suggesting that habitual consumption of folate-fortified foods is a practical approach in providing consistent protection to those children who may benefit the most, i.e., carriers of the TT genotype.	Folic Acid	21-27	methylenetetrahydrofolate reductase	Homo sapiens	77-82
20097536-14	2010	Also, consumption of folate-fortified foods modulates the association of the MTHFR 677C&gt;T polymorphism with tHcy, suggesting that habitual consumption of folate-fortified foods is a practical approach in providing consistent protection to those children who may benefit the most, i.e., carriers of the TT genotype.	Folic Acid	157-163	methylenetetrahydrofolate reductase	Homo sapiens	77-82
20501616-1	2010	PURPOSE: Pralatrexate (10-propargyl-10-deazaaminopterin) is an antifolate with improved cellular uptake and retention due to greater affinity for the reduced folate carrier (RFC-1) and folyl-polyglutamyl synthase.	Folic Acid	67-73	replication factor C subunit 1	Homo sapiens	174-179
20504979-2	2010	The methylenetetrahydrofolate reductase (MTHFR) gene is important for folate metabolism, and 2 common polymorphisms, C677T and A1298C, reduce enzymatic activity; C677T is present at high penetrance in Mexican populations.	Folic Acid	23-29	methylenetetrahydrofolate reductase	Homo sapiens	41-46
20207735-2	2010	It is known that mutations in the human ALDH7A1 gene cause pyridoxine-dependent and folic acid-responsive seizures.	Folic Acid	84-94	aldehyde dehydrogenase 7 family member A1	Homo sapiens	40-47
20090312-0	2010	Effects of dietary folic acid on the expression of myelin basic protein in the brain and spinal cord of pregnant and lactating rats.	Folic Acid	19-29	myelin basic protein	Rattus norvegicus	51-71
20090312-1	2010	BACKGROUND/AIMS: This study investigated the effects of dietary folic acid on the expression of myelin basic protein (MBP) in the maternal brain and spinal cord during pregnancy and lactation.	Folic Acid	64-74	myelin basic protein	Rattus norvegicus	96-116
20090312-1	2010	BACKGROUND/AIMS: This study investigated the effects of dietary folic acid on the expression of myelin basic protein (MBP) in the maternal brain and spinal cord during pregnancy and lactation.	Folic Acid	64-74	myelin basic protein	Rattus norvegicus	118-121
19360465-3	2010	Of the analyzed genes, ERCC2, XRCC1, XRCC2, XRCC3 and Lig4 participate in DNA repair, TP53 in cell cycle check point control, AIB1, AR, COMT, CYP11A1, CYP17A1, CYP19A1, HSD17 and PGR in steroid hormone biosynthesis/metabolism/signaling, TYMS in folate metabolism and HER2, IL6, LRP1, TGFB and TGFBR1 affect cell growth.	Folic Acid	245-251	X-ray repair cross complementing 1	Homo sapiens	30-35
19360465-3	2010	Of the analyzed genes, ERCC2, XRCC1, XRCC2, XRCC3 and Lig4 participate in DNA repair, TP53 in cell cycle check point control, AIB1, AR, COMT, CYP11A1, CYP17A1, CYP19A1, HSD17 and PGR in steroid hormone biosynthesis/metabolism/signaling, TYMS in folate metabolism and HER2, IL6, LRP1, TGFB and TGFBR1 affect cell growth.	Folic Acid	245-251	X-ray repair cross complementing 3	Homo sapiens	44-49
19360465-3	2010	Of the analyzed genes, ERCC2, XRCC1, XRCC2, XRCC3 and Lig4 participate in DNA repair, TP53 in cell cycle check point control, AIB1, AR, COMT, CYP11A1, CYP17A1, CYP19A1, HSD17 and PGR in steroid hormone biosynthesis/metabolism/signaling, TYMS in folate metabolism and HER2, IL6, LRP1, TGFB and TGFBR1 affect cell growth.	Folic Acid	245-251	ANIB1	Homo sapiens	126-130
19360465-3	2010	Of the analyzed genes, ERCC2, XRCC1, XRCC2, XRCC3 and Lig4 participate in DNA repair, TP53 in cell cycle check point control, AIB1, AR, COMT, CYP11A1, CYP17A1, CYP19A1, HSD17 and PGR in steroid hormone biosynthesis/metabolism/signaling, TYMS in folate metabolism and HER2, IL6, LRP1, TGFB and TGFBR1 affect cell growth.	Folic Acid	245-251	hydroxysteroid 17-beta dehydrogenase 1 pseudogene 1	Homo sapiens	169-174
19959403-11	2010	We also confirmed that MTHFR polymorphism has a significant effect on folate distribution in this small population of non-supplemented subjects.	Folic Acid	70-76	methylenetetrahydrofolate reductase	Homo sapiens	23-28
19694922-0	2010	Treatment of erectile dysfunction due to C677T mutation of the MTHFR gene with vitamin B6 and folic acid in patients non responders to PDE5i.	Folic Acid	94-104	methylenetetrahydrofolate reductase	Homo sapiens	63-68
19283448-14	2010	Folate mean concentration was significantly lower in carriers of the wild-type MTHFR 1298AA genotype (P = 0.010).	Folic Acid	0-6	methylenetetrahydrofolate reductase	Homo sapiens	79-84
19283448-15	2010	CONCLUSION: Our results suggest a correlation between the MTHFR A1298C polymorphism and plasma folate concentration.	Folic Acid	95-101	methylenetetrahydrofolate reductase	Homo sapiens	58-63
27315223-5	2016	Loss of MTHFD2 caused MCF7 cells to become glycine auxotrophs, that is, reliant on exogenous glycine, and more sensitive to exogenous folate depletion.	Folic Acid	134-140	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	Homo sapiens	8-14
27520898-1	2016	The 5,10-methylenetetrahydrofolate reductase (MTHFR) gene plays a central role in folate metabolism.	Folic Acid	28-34	methylenetetrahydrofolate reductase	Homo sapiens	46-51
27173682-2	2016	C677T and A1298C MTHFR polymorphisms produce an enzyme with reduced folate-related one carbon metabolism, and this has been associated with aberrant methylation modifications in DNA and protein.	Folic Acid	68-74	methylenetetrahydrofolate reductase	Homo sapiens	17-22
27259274-0	2016	Folate-targeted star-shaped cationic copolymer co-delivering docetaxel and MMP-9 siRNA for nasopharyngeal carcinoma therapy.	Folic Acid	0-6	matrix metallopeptidase 9	Homo sapiens	75-80
27259274-2	2016	Based on our previous work, to co-deliver docetaxel (DOC) and MMP-9 siRNA more efficiently for HNE-1 nasopharyngeal carcinoma therapy, a folate-modified star-shaped copolymer (FA-CD-PLLD) consisting of beta-cyclodextrin (CD) and poly(L-lysine) dendron (PLLD) was synthesized, and then used for DOC and MMP-9 co-delivery.	Folic Acid	137-143	matrix metallopeptidase 9	Homo sapiens	62-67
27259274-2	2016	Based on our previous work, to co-deliver docetaxel (DOC) and MMP-9 siRNA more efficiently for HNE-1 nasopharyngeal carcinoma therapy, a folate-modified star-shaped copolymer (FA-CD-PLLD) consisting of beta-cyclodextrin (CD) and poly(L-lysine) dendron (PLLD) was synthesized, and then used for DOC and MMP-9 co-delivery.	Folic Acid	137-143	matrix metallopeptidase 9	Homo sapiens	302-307
28149369-7	2016	The analysis of the alleles of the MTHFR C677T polymorphism showed that the participants that carried TT genotypes had a lower level of vitamin B12 and folate, and a higher level of Hcy than the participants carrying CC and CT genotypes.	Folic Acid	152-158	methylenetetrahydrofolate reductase	Homo sapiens	35-40
27068821-1	2016	MTHFR is an important enzyme in the metabolism of folic acid and is crucial for reproductive function.	Folic Acid	50-60	methylenetetrahydrofolate reductase	Homo sapiens	0-5
27386651-12	2016	Compared with the model group, mRNA expression of DNMT1 in Ang II induced VSMCs was obviously enhanced in the folate group and the PQR group (P &lt; 0.01).	Folic Acid	110-116	DNA methyltransferase 1	Homo sapiens	50-55
26989972-6	2016	In contrast, female pups from folic acid-supplemented dams were 5% lighter than those from control-fed dams and had lower proopiomelanocortin (Pomc) (42%), Lepr (32%), and Agrp (13%), but higher neuropeptide Y (Npy) (18%) mRNA expression.	Folic Acid	30-40	proopiomelanocortin	Rattus norvegicus	122-141
26989972-6	2016	In contrast, female pups from folic acid-supplemented dams were 5% lighter than those from control-fed dams and had lower proopiomelanocortin (Pomc) (42%), Lepr (32%), and Agrp (13%), but higher neuropeptide Y (Npy) (18%) mRNA expression.	Folic Acid	30-40	proopiomelanocortin	Rattus norvegicus	143-147
26879531-3	2016	As folate levels may also be influenced by the C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene, we hypothesize that a gene-environment interaction between this polymorphism and folic acid use is involved in the etiology of hypospadias.	Folic Acid	3-9	methylenetetrahydrofolate reductase	Homo sapiens	73-108
26879531-3	2016	As folate levels may also be influenced by the C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene, we hypothesize that a gene-environment interaction between this polymorphism and folic acid use is involved in the etiology of hypospadias.	Folic Acid	3-9	methylenetetrahydrofolate reductase	Homo sapiens	110-115
26879531-3	2016	As folate levels may also be influenced by the C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene, we hypothesize that a gene-environment interaction between this polymorphism and folic acid use is involved in the etiology of hypospadias.	Folic Acid	204-214	methylenetetrahydrofolate reductase	Homo sapiens	73-108
26879531-3	2016	As folate levels may also be influenced by the C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene, we hypothesize that a gene-environment interaction between this polymorphism and folic acid use is involved in the etiology of hypospadias.	Folic Acid	204-214	methylenetetrahydrofolate reductase	Homo sapiens	110-115
25412139-1	2016	The human methylenetetrahydrofolate reductase (MTHFR) gene encodes one of the key enzymes in folate metabolism.	Folic Acid	29-35	methylenetetrahydrofolate reductase	Homo sapiens	47-52
26974319-6	2016	Pretreating THP-1 cells with folic acid attenuated hypoxia-induced inflammatory responses, including a decrease in protein and mRNA levels of interleukin (IL)-1beta and tumor necrosis factor-alpha (TNF-alpha), coupled with increased levels of IL-10.	Folic Acid	29-39	interleukin 10	Homo sapiens	243-248
26687138-1	2016	PURPOSE: 5,10-Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism and plays a major role in DNA methylation.	Folic Acid	33-39	methylenetetrahydrofolate reductase	Homo sapiens	51-56
26687138-2	2016	There are two popular MTHFR polymorphisms known as C677T and A1298C which are found to be involved in folate metabolism and lowering the enzyme activity, thus may be linked with cancer development.	Folic Acid	102-108	methylenetetrahydrofolate reductase	Homo sapiens	22-27
26880641-5	2016	Both DMGDH and SDH contain FAD and both have tightly bound tetrahydrofolate (THF), a folate coenzyme.	Folic Acid	69-75	dimethylglycine dehydrogenase	Homo sapiens	5-10
26880641-5	2016	Both DMGDH and SDH contain FAD and both have tightly bound tetrahydrofolate (THF), a folate coenzyme.	Folic Acid	69-75	sarcosine dehydrogenase	Homo sapiens	15-18
26438060-1	2016	The 5,10-methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS) are critical enzymes in folate metabolism.	Folic Acid	28-34	methylenetetrahydrofolate reductase	Homo sapiens	46-51
26438060-3	2016	We investigated the risks of adult leukemia with genetic polymorphisms of folate metabolic enzymes (MTHFR C677T, A1298C, and TS) and evaluated if the associations varied by dietary folate intake from a multicenter case-control study conducted in Chinese.	Folic Acid	74-80	methylenetetrahydrofolate reductase	Homo sapiens	100-105
26438060-9	2016	Stratified analysis by dietary folate intake showed the increased risks of leukemia with the MTHFR 677TT and TS 2R3R/2R2R genotypes were only significant in individuals with low folate intake.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	93-98
26438060-9	2016	Stratified analysis by dietary folate intake showed the increased risks of leukemia with the MTHFR 677TT and TS 2R3R/2R2R genotypes were only significant in individuals with low folate intake.	Folic Acid	178-184	methylenetetrahydrofolate reductase	Homo sapiens	93-98
26438060-11	2016	This study suggests that dietary folate intake and gender may modify the associations between MTHFR/TS polymorphisms and adult leukemia risk.	Folic Acid	33-39	methylenetetrahydrofolate reductase	Homo sapiens	94-99
26111718-5	2016	Circulating folate and homocysteine levels as well as MTHFR genotype, while emerging as major predictors of the risk of vascular events and of the efficacy of folic acid therapy, have also proved to be determinants of an interindividual variability in the degree of lipid peroxidation and platelet activation, and of the extent of their downregulation by folic acid.	Folic Acid	159-169	methylenetetrahydrofolate reductase	Homo sapiens	54-59
26111718-5	2016	Circulating folate and homocysteine levels as well as MTHFR genotype, while emerging as major predictors of the risk of vascular events and of the efficacy of folic acid therapy, have also proved to be determinants of an interindividual variability in the degree of lipid peroxidation and platelet activation, and of the extent of their downregulation by folic acid.	Folic Acid	355-365	methylenetetrahydrofolate reductase	Homo sapiens	54-59
29859029-0	2016	[Folic acid modified polyrotaxanes effectively transfer si RNA-CD47 to inhibit the proliferation of melanoma].	Folic Acid	1-11	CD47 antigen (Rh-related antigen, integrin-associated signal transducer)	Mus musculus	63-67
29859029-1	2016	To investigate the effect that folic acid-modified polyrotaxanes(FPP) transfered siRNA CD47 to inhibit melanoma proliferation, the expression of CD47 in clinical melanoma patients was tested by Western blot and RT-PCR, respectively.	Folic Acid	31-41	CD47 molecule	Homo sapiens	87-91
29859029-1	2016	To investigate the effect that folic acid-modified polyrotaxanes(FPP) transfered siRNA CD47 to inhibit melanoma proliferation, the expression of CD47 in clinical melanoma patients was tested by Western blot and RT-PCR, respectively.	Folic Acid	31-41	CD47 molecule	Homo sapiens	145-149
27014653-1	2016	BACKGROUND: Association between C677T polymorphism of the methylenetetrahydrofolate reductase (MTHFR), a key enzyme involved in folate metabolism and DNA methylation, and breast cancer risk are inconsistent.	Folic Acid	77-83	methylenetetrahydrofolate reductase	Homo sapiens	95-100
26311115-4	2016	Folic acid-induced acute kidney injury increased calvaria FGF23 mRNA and serum FGF23 and parathyroid hormone (PTH) levels at 6 h. The FGFR1 receptor inhibitor PD173074 prevented the folic acid-induced increase in both FGF23 mRNA and serum levels but had no effect on serum PTH levels.	Folic Acid	0-10	Fibroblast growth factor receptor 1	Rattus norvegicus	134-139
26311115-4	2016	Folic acid-induced acute kidney injury increased calvaria FGF23 mRNA and serum FGF23 and parathyroid hormone (PTH) levels at 6 h. The FGFR1 receptor inhibitor PD173074 prevented the folic acid-induced increase in both FGF23 mRNA and serum levels but had no effect on serum PTH levels.	Folic Acid	182-192	Fibroblast growth factor receptor 1	Rattus norvegicus	134-139
26652418-0	2016	Hybrid molecularly imprinted poly(methacrylic acid-TRIM)-silica chemically modified with (3-glycidyloxypropyl)trimethoxysilane for the extraction of folic acid in aqueous medium.	Folic Acid	149-159	T cell receptor associated transmembrane adaptor 1	Homo sapiens	51-55
26689915-1	2016	INTRODUCTION: In view of our previous studies showing an independent association of genetic polymorphisms in folate, xenobiotic, and toll-like receptor (TLR) pathways with the risk for systemic lupus erythematosus (SLE), we have developed three statistical models to delineate complex gene-gene interactions between folate, xenobiotic, TLR, and signal transducer and activator of transcription 4 (STAT4) signaling pathways in association with the molecular pathophysiology of SLE.	Folic Acid	109-115	signal transducer and activator of transcription 4	Homo sapiens	345-395
26689915-1	2016	INTRODUCTION: In view of our previous studies showing an independent association of genetic polymorphisms in folate, xenobiotic, and toll-like receptor (TLR) pathways with the risk for systemic lupus erythematosus (SLE), we have developed three statistical models to delineate complex gene-gene interactions between folate, xenobiotic, TLR, and signal transducer and activator of transcription 4 (STAT4) signaling pathways in association with the molecular pathophysiology of SLE.	Folic Acid	109-115	signal transducer and activator of transcription 4	Homo sapiens	397-402
26526964-2	2016	Deficiencies of folate and vitamin B-6 (pyridoxal 5"-phosphate, PLP) may cause hyperhomocysteinemia and increased oxidative stress.	Folic Acid	16-22	proteolipid protein 1	Homo sapiens	64-67
32263218-0	2016	Folate-targeting redox hyperbranched poly(amido amine)s delivering MMP-9 siRNA for cancer therapy.	Folic Acid	0-6	matrix metallopeptidase 9	Homo sapiens	67-72
26273990-1	2016	Methylenetetrahydrofolate reductase (MTHFR) protein catalyzes the only biochemical reaction which produces methyltetrahydrofolate, the active form of folic acid essential for several molecular functions.	Folic Acid	150-160	methylenetetrahydrofolate reductase	Homo sapiens	0-35
26273990-1	2016	Methylenetetrahydrofolate reductase (MTHFR) protein catalyzes the only biochemical reaction which produces methyltetrahydrofolate, the active form of folic acid essential for several molecular functions.	Folic Acid	150-160	methylenetetrahydrofolate reductase	Homo sapiens	37-42
25796308-1	2015	BACKGROUND: Methylenetetrahydrofolate Reductase (MTHFR) polymorphisms by impairing folate metabolism may influence the development of allergic diseases.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	49-54
26380869-1	2015	Methylenetetrahydrofolate reductase (MTHFR) functions as a main regulatory enzyme in folate metabolism.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
26461067-9	2015	These findings suggest a previously unknown role for MTHFD2 in cancer cell proliferation, adding to its known function in mitochondrial folate metabolism.	Folic Acid	136-142	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	Homo sapiens	53-59
26523551-1	2015	Methionine synthase (MTR) plays a crucial role in maintaining homeostasis of intracellular methionine, folate, and homocysteine, and its activity correlates with DNA methylation in many mammalian tissues.	Folic Acid	103-109	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	0-19
26299783-2	2015	Folate deficiency has been associated with placenta-related pregnancy complications, as have SNP in genes of the folate-dependent enzymes, methionine synthase (MTR) and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1).	Folic Acid	113-119	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	139-158
26337056-12	2015	MTHFR C677T and A1298C with low folate showed higher odds of low levels of high-density lipoprotein cholesterol (P for trend: 0.008 and 0.031).	Folic Acid	32-38	methylenetetrahydrofolate reductase	Homo sapiens	0-5
26309907-3	2015	In this study, our goal was to confirm these findings and determine the apparent Michaelis-Menten kinetic constants (Vmax and Km) of the folate-dependent AcCoA hydrolysis for human NAT1/NAT2, and the rodent analogs rat Nat1/Nat2, mouse Nat1/Nat2, and hamster Nat1/Nat2.	Folic Acid	137-143	N-acetyltransferase 2	Homo sapiens	186-190
26309907-3	2015	In this study, our goal was to confirm these findings and determine the apparent Michaelis-Menten kinetic constants (Vmax and Km) of the folate-dependent AcCoA hydrolysis for human NAT1/NAT2, and the rodent analogs rat Nat1/Nat2, mouse Nat1/Nat2, and hamster Nat1/Nat2.	Folic Acid	137-143	N-acetyltransferase 2	Rattus norvegicus	224-228
26309907-3	2015	In this study, our goal was to confirm these findings and determine the apparent Michaelis-Menten kinetic constants (Vmax and Km) of the folate-dependent AcCoA hydrolysis for human NAT1/NAT2, and the rodent analogs rat Nat1/Nat2, mouse Nat1/Nat2, and hamster Nat1/Nat2.	Folic Acid	137-143	N-acetyltransferase 2	Homo sapiens	241-245
26309907-5	2015	Human NAT1 and its rodent analogs rat Nat2, mouse Nat2 and hamster Nat2 catalyzed AcCoA hydrolysis in a folate-dependent manner.	Folic Acid	104-110	N-acetyltransferase 2	Rattus norvegicus	38-42
26309907-5	2015	Human NAT1 and its rodent analogs rat Nat2, mouse Nat2 and hamster Nat2 catalyzed AcCoA hydrolysis in a folate-dependent manner.	Folic Acid	104-110	N-acetyltransferase 2	Homo sapiens	50-54
25105440-2	2015	The genes MTHFR, MTR, MTRR, and TCN2 play key roles in folate metabolism.	Folic Acid	55-61	methylenetetrahydrofolate reductase	Homo sapiens	10-15
26334892-2	2015	Besides, methionine synthase (MTR) gene and methionine synthase reductase (MTRR) gene were folate metabolism involved genes and had been investigated in several previous studies with inconsistent results.	Folic Acid	91-97	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	9-28
26177356-3	2015	We hypothesized that a folic acid (FA) deficient diet would induce genotoxicity in mice as measured by the Pig-a mutant phenotype (CD24-) and micronuclei (MN) in reticulocytes (RET) and red blood cells/normochromatic erythrocytes (RBC/NCE).	Folic Acid	23-33	phosphatidylinositol glycan anchor biosynthesis class A	Sus scrofa	107-112
26154858-2	2015	The mammalian folic acid cycle is highly complex and the enzymes, methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and methionine synthase reductase (MTRR), have crucial roles in this metabolic pathway.	Folic Acid	14-24	methylenetetrahydrofolate reductase	Homo sapiens	66-101
26154858-2	2015	The mammalian folic acid cycle is highly complex and the enzymes, methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and methionine synthase reductase (MTRR), have crucial roles in this metabolic pathway.	Folic Acid	14-24	methylenetetrahydrofolate reductase	Homo sapiens	103-108
26154858-2	2015	The mammalian folic acid cycle is highly complex and the enzymes, methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and methionine synthase reductase (MTRR), have crucial roles in this metabolic pathway.	Folic Acid	14-24	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	111-130
25833982-12	2015	These findings provide new insights into the metabolic impairments and mechanisms of folate-responsive NTDs resulting from decreased Shmt1 expression.	Folic Acid	85-91	serine hydroxymethyltransferase 1 (soluble)	Mus musculus	133-138
26140186-1	2015	BACKGROUND: The purpose of this study was to describe the association of MTHFR gene single nucleotide polymorphisms (C677T and A1298C) and maternal supplementary folate intake with orofacial clefts in the Iranian population.	Folic Acid	162-168	methylenetetrahydrofolate reductase	Homo sapiens	73-78
25535303-6	2015	After induction of folic acid nephropathy or unilateral ureteral obstruction, TbetaRII(endo+/-) mice exhibited less tubulointerstitial fibrosis, enhanced preservation of renal microvasculature, improvement in renal blood flow, and less tissue hypoxia than TbetaRII(endo+/+) counterparts.	Folic Acid	19-29	transforming growth factor, beta receptor II	Mus musculus	78-86
25219684-8	2015	Patients and their mothers carrying the MTHFR 667T allele showed lower serum folate than CC (P = 0.011 and P = 0.030, respectively).	Folic Acid	77-83	methylenetetrahydrofolate reductase	Homo sapiens	40-45
25510667-1	2015	The methylenetetrahydrofolate reductase (MTHFR) 677 C&gt;T and 1298 A&gt;C polymorphisms are associated with variations in folate levels, a phenomenon linked to the development of various malignancies.	Folic Acid	23-29	methylenetetrahydrofolate reductase	Homo sapiens	41-46
25781218-5	2015	The endometrium decidual tissue of the folate deficiency group expressed less Bax compared to the normal diet group while they had nearly equal expression of Bcl2 protein.	Folic Acid	39-45	BCL2-associated X protein	Mus musculus	78-81
26045811-8	2015	In human extravillous trophoblast HTR8/SVneo, folate ameliorated the Dex-induced supress of cell migration and improved the expression/activity of MMP2 and MMP9.	Folic Acid	46-52	matrix metallopeptidase 9	Homo sapiens	156-160
26259392-2	2015	Methlenetetrahydrofolate reductase (MTHFR) mutation are commonly linked to folate metabolism with increased risk factor for the development of neural tube defects, recurrent pregnancy loss and development of several type of cancer but genetic interaction between two alleles of MTHFR has been poorly defined in ovarian cancer in India.	Folic Acid	18-24	methylenetetrahydrofolate reductase	Homo sapiens	36-41
26259392-2	2015	Methlenetetrahydrofolate reductase (MTHFR) mutation are commonly linked to folate metabolism with increased risk factor for the development of neural tube defects, recurrent pregnancy loss and development of several type of cancer but genetic interaction between two alleles of MTHFR has been poorly defined in ovarian cancer in India.	Folic Acid	18-24	methylenetetrahydrofolate reductase	Homo sapiens	278-283
28316696-1	2015	Background: One of the notable enzymes in the metabolism of folate is Methylenetetrahydrofolate reductase enzyme, this enzyme is necessary for some biological mechanisms.	Folic Acid	60-66	methylenetetrahydrofolate reductase	Homo sapiens	70-105
26421712-1	2015	AIM: The aim of this study was to investigate possible relationships among the A1298C (rs1801131) and C677T (rs1801133) polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene and levels of homocysteine, vitamins B6, B12, folic acid and lipid profile, including oxidized low-density lipoprotein (ox-LDL), of adolescents at cardiovascular risk.	Folic Acid	236-246	methylenetetrahydrofolate reductase	Homo sapiens	141-176
25260219-2	2014	We developed and studied a hybrid nanoporous microparticle (hNP) carrier based on calcium carbonate and biopolymers derivatized with folic acid (FA) and containing Dox as a chemotherapeutic drug model.	Folic Acid	133-143	kallikrein related peptidase 8	Homo sapiens	60-63
25366783-1	2014	We investigated the association between dietary intake of folate, vitamin B6, and the 5,10-methylenetetrahydrofolate reductase (MTHFR) genotype with breast cancer.	Folic Acid	58-64	methylenetetrahydrofolate reductase	Homo sapiens	86-126
25366783-1	2014	We investigated the association between dietary intake of folate, vitamin B6, and the 5,10-methylenetetrahydrofolate reductase (MTHFR) genotype with breast cancer.	Folic Acid	58-64	methylenetetrahydrofolate reductase	Homo sapiens	128-133
25302494-0	2014	A lower degree of PBMC L1 methylation in women with lower folate status may explain the MTHFR C677T polymorphism associated higher risk of CIN in the US post folic acid fortification era.	Folic Acid	158-168	methylenetetrahydrofolate reductase	Homo sapiens	88-93
25302494-1	2014	BACKGROUND: Studies in populations unexposed to folic acid (FA) fortification have demonstrated that MTHFR C677T polymorphism is associated with increased risk of higher grades of cervical intraepithelial neoplasia (CIN 2+).	Folic Acid	48-58	methylenetetrahydrofolate reductase	Homo sapiens	101-106
25302494-2	2014	However, it is unknown whether exposure to higher folate as a result of the FA fortification program has altered the association between MTHFR C677T and risk of CIN, or the mechanisms involved with such alterations.	Folic Acid	50-56	methylenetetrahydrofolate reductase	Homo sapiens	137-142
25116278-0	2014	Folic acid functionalized silver nanoparticles with sensitivity and selectivity colorimetric and fluorescent detection for Hg2+ and efficient catalysis.	Folic Acid	0-10	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	123-126
25036376-1	2014	Methylene-tetrahydrofolate reductase (MTHFR) is a key enzyme of folate metabolism.	Folic Acid	20-26	methylenetetrahydrofolate reductase	Homo sapiens	38-43
24984268-2	2014	In this study, we developed folate-modified curcumin (Cur) loaded micelles (Cur-FPPs) for cancer chemotherapy.	Folic Acid	28-34	farnesyl diphosphate synthase	Homo sapiens	80-84
24894669-1	2014	An increasing body of evidence has shown that the amino acid changes at position 1298 might eliminate methylenetetrahydrofolate reductase (MTHFR) enzyme activity, leading to insufficient folic acid and subsequent human chromosome breakage.	Folic Acid	187-197	methylenetetrahydrofolate reductase	Homo sapiens	102-137
24894669-1	2014	An increasing body of evidence has shown that the amino acid changes at position 1298 might eliminate methylenetetrahydrofolate reductase (MTHFR) enzyme activity, leading to insufficient folic acid and subsequent human chromosome breakage.	Folic Acid	187-197	methylenetetrahydrofolate reductase	Homo sapiens	139-144
25202269-6	2014	Dietary folate deficiency significantly decreased LCMT1, methylated PP2A and PP2A/Balpha levels in all brain regions examined from aged Mthfr (+/+) mice, and further exacerbated the regional effects of MTHFR deficiency in aged Mthfr (+/-) mice.	Folic Acid	8-14	protein phosphatase 2, regulatory subunit A, alpha	Mus musculus	68-72
25202269-6	2014	Dietary folate deficiency significantly decreased LCMT1, methylated PP2A and PP2A/Balpha levels in all brain regions examined from aged Mthfr (+/+) mice, and further exacerbated the regional effects of MTHFR deficiency in aged Mthfr (+/-) mice.	Folic Acid	8-14	protein phosphatase 2, regulatory subunit A, alpha	Mus musculus	77-81
25232375-0	2014	Folate deficiency exacerbates apoptosis by inducing hypomethylation and resultant overexpression of DR4 together with altering DNMTs in Alzheimer"s disease.	Folic Acid	0-6	major histocompatibility complex, class II, DR beta 4	Homo sapiens	100-103
25232375-9	2014	DNMT1 and DNMT3a mRNA level were elevated (P &lt; 0.05) in AD patients and folate deficient medium cultured cells compared with controls (P &lt; 0.05), together with lower folate concentration in AD.	Folic Acid	75-81	DNA methyltransferase 1	Homo sapiens	0-5
25232375-11	2014	In summary, folate deficiency can induce apoptosis by increasing DR4 expression with DNA promoter hypomethylation in AD, together with upregulating DNMTs expression, which may be associated with folate deficiency-induced DNA damage.	Folic Acid	12-18	major histocompatibility complex, class II, DR beta 4	Homo sapiens	65-68
24874916-6	2014	DNA methylation at the PLAGL1, SGCE, DLK1/MEG3 and IGF2/H19 DMRs was associated with maternal folate levels and also birth weight, suggestive of threshold effects.	Folic Acid	94-100	PLAG1 like zinc finger 1	Homo sapiens	23-29
24726863-2	2014	AS3MT activity requires the presence of the methyl donor S-adenosylmethionine, a product of folate-dependent one-carbon metabolism, and a reductant.	Folic Acid	92-98	arsenite methyltransferase	Homo sapiens	0-5
25079578-1	2014	BACKGROUND: 5,10-Methylenetetrahydrofolate reductase (MTHFR) deficiency is an inborn error of the folate-recycling pathway that affects the remethylation of homocysteine to methionine.	Folic Acid	36-42	methylenetetrahydrofolate reductase	Homo sapiens	54-59
25140779-0	2014	[Association of folate metabolism genes MTRR and MTHFR with complex congenital abnormalities among Chinese population in Shanxi Province, China].	Folic Acid	16-22	methylenetetrahydrofolate reductase	Homo sapiens	49-54
25078601-7	2014	We found any interaction between MTHFR C677T and folate intake (P for interaction = 0.02).	Folic Acid	49-55	methylenetetrahydrofolate reductase	Homo sapiens	33-38
25000295-13	2014	Taken together, these results indicate that AtDFB is required for seed reserves, hypocotyl elongation and N metabolism in darkness, providing novel insights into potential associations of folate metabolism with seed reserve accumulation, N metabolism and hypocotyl development in Arabidopsis.	Folic Acid	188-194	DHFS-FPGS homolog B	Arabidopsis thaliana	44-49
25221392-4	2014	We hypothesize that the polymorphisms in ABCB1, Cyp2C9, Cyp2C19 and methylene tetrahydrofolate reductase (MTHFR) might result in differential expression resulting in differential drug transport, drug metabolism and folate metabolism, which in turn may contribute to the teratogenic impact of AEDs.	Folic Acid	88-94	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	56-63
25221392-4	2014	We hypothesize that the polymorphisms in ABCB1, Cyp2C9, Cyp2C19 and methylene tetrahydrofolate reductase (MTHFR) might result in differential expression resulting in differential drug transport, drug metabolism and folate metabolism, which in turn may contribute to the teratogenic impact of AEDs.	Folic Acid	88-94	methylenetetrahydrofolate reductase	Homo sapiens	106-111
24814647-5	2014	Homocysteine-lowering therapy with folic acid in patients with coronary artery disease significantly improve FMD as compared with placebo using random-effect model (SMD = 1.65 with 95% CI 1.12-2.17, p &lt; 0.001).	Folic Acid	35-45	small nuclear ribonucleoprotein D1 polypeptide	Homo sapiens	165-172
25237572-3	2014	Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
24970119-2	2014	Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme of the folate/methionine metabolic pathway and it is well established fact that folate deficiency causes pregnancy complications like recurrent pregnancy loss, preeclempsia and birth defects affected pregnancies.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
23807201-9	2014	A folate-MTHFR genotype interaction on CRT risk was found (P = 0.037): in the lower folate subgroup, TT patients showed a 2.4 higher OR for CRT (95% CI 0.484-11.891; P NS) than C-allele carriers.	Folic Acid	84-90	methylenetetrahydrofolate reductase	Homo sapiens	9-14
23807201-11	2014	CONCLUSIONS: In this cohort of acromegalic patients, CRT risk is increased in 677TT MTHFR patients with low plasma folate levels.	Folic Acid	115-121	methylenetetrahydrofolate reductase	Homo sapiens	84-89
24746944-9	2014	The gene MTHFR encodes the 5-MTHFR enzyme, which is involved in folate metabolism, and C677T/A1298C polymorphisms of this gene are related to decreased enzyme activity and consequent changes in homocysteine concentration.	Folic Acid	64-70	methylenetetrahydrofolate reductase	Homo sapiens	9-14
24746944-9	2014	The gene MTHFR encodes the 5-MTHFR enzyme, which is involved in folate metabolism, and C677T/A1298C polymorphisms of this gene are related to decreased enzyme activity and consequent changes in homocysteine concentration.	Folic Acid	64-70	methylenetetrahydrofolate reductase	Homo sapiens	29-34
24639464-7	2014	Moreover, the folic-acid-dependent gene Alx3 is significantly downregulated in Lrp2 mutants.	Folic Acid	14-24	aristaless-like homeobox 3	Mus musculus	40-44
24385382-1	2014	Genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) gene are considered to have some influence on both folate metabolism and cancer risk.	Folic Acid	44-50	methylenetetrahydrofolate reductase	Homo sapiens	62-67
24559276-3	2014	The serine hydroxymethyhransferase (SHMT), methionine synthase (MS), methionine synthase reductase (MTRR) and cystathionine beta synthase (CBS) regulate key reactions in the folate and Hcy metabolism.	Folic Acid	174-180	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	43-62
24558445-4	2014	In a separate group, animals were treated orally with folic acid (FA), which is known to recouple eNOS through augmentation of dihydrofolate reductase (DHFR) function.	Folic Acid	54-64	dihydrofolate reductase	Mus musculus	127-150
24558445-4	2014	In a separate group, animals were treated orally with folic acid (FA), which is known to recouple eNOS through augmentation of dihydrofolate reductase (DHFR) function.	Folic Acid	54-64	dihydrofolate reductase	Mus musculus	152-156
24596472-0	2014	Folate Levels and Polymorphisms in the Genes MTHFR, MTR, and TS in Colorectal Cancer.	Folic Acid	0-6	methylenetetrahydrofolate reductase	Homo sapiens	45-50
24490800-1	2014	BACKGROUND: Methylentetrahydrofolate reductase (MTHFR) plays a major role in folate metabolism and consequently could be an important factor for the efficacy of a treatment with 5-fluorouracil.	Folic Acid	30-36	methylenetetrahydrofolate reductase	Homo sapiens	48-53
25081713-1	2014	BACKGROUND: Methylenetetrahydrofolate (MTHFR) is the key enzyme of the folate metabolic pathway and several studies have pointed to association between the MTHFR C677T polymorphism and breast cancer risk.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	39-44
25081713-1	2014	BACKGROUND: Methylenetetrahydrofolate (MTHFR) is the key enzyme of the folate metabolic pathway and several studies have pointed to association between the MTHFR C677T polymorphism and breast cancer risk.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	156-161
24995314-3	2014	A common c.80G>A polymorphism (rs1051266) in the gene coding for the reduced folate carrier (SLC19A1 gene, commonly known as RFC-1 gene) was investigated as AD risk factor in Asian populations, yielding conflicting results.	Folic Acid	77-83	replication factor C subunit 1	Homo sapiens	125-130
24277487-0	2014	5,10-Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms: genotype frequency and association with homocysteine and folate levels in middle-southern Italian adults.	Folic Acid	24-30	methylenetetrahydrofolate reductase	Homo sapiens	42-47
24277487-1	2014	Two genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) gene (C677T and A1298C) can influence the plasma homocysteine (Hcy) levels, especially in the presence of an inadequate folate status.	Folic Acid	48-54	methylenetetrahydrofolate reductase	Homo sapiens	66-71
24277487-2	2014	The aim of this study was to evaluate the frequencies of C677T and of A1298C MTHFR polymorphisms and their correlation with Hcy and serum folate concentrations in a population of blood donors living in a region of middle-southern Italy (the Molise Region).	Folic Acid	138-144	methylenetetrahydrofolate reductase	Homo sapiens	77-82
24277487-7	2014	In conclusion, we found a high frequency of MTHFR allele associated with high level of Hcy and low levels of folate in an Italian southern population.	Folic Acid	109-115	methylenetetrahydrofolate reductase	Homo sapiens	44-49
23888945-6	2014	In addition, the expression of DNMT1 protein and mRNA was measured in cervical cancer cells (Caski and C33A) treated by different concentration of folate.	Folic Acid	147-153	DNA methyltransferase 1	Homo sapiens	31-36
23888945-8	2014	It was found that folate was able to reduce the viability of Caski or C33A cell (r=0.978, P=0.002; r=0.984, P&lt;0.001) and regulated aberrant expression of DNMT1 protein (r=-0.859, P=0.01; r=-0.914, P&lt;0.001) and mRNA (r=-0.297, P=0.159; r=0.433, P=0.034) in vitro.	Folic Acid	18-24	DNA methyltransferase 1	Homo sapiens	157-162
25070812-1	2014	OBJECTIVES: Methylenetetrahydrofolate reductase (MTHFR) enzyme plays an important role in folate metabolism and MTHFR C677T polymorphism has been suggested as a risk factor to various cancers.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	49-54
25070812-1	2014	OBJECTIVES: Methylenetetrahydrofolate reductase (MTHFR) enzyme plays an important role in folate metabolism and MTHFR C677T polymorphism has been suggested as a risk factor to various cancers.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	112-117
24052451-2	2014	5,10-methylenetetrahydrofolate reductase (MTHFR) is a folate-dependent enzyme that catalyzed remethylation of homocysteine (Hcy) and the MTHFR C677T polymorphism makes the MTHFR enzyme thermolabile causing hyperhomocysteinemia.	Folic Acid	24-30	methylenetetrahydrofolate reductase	Homo sapiens	42-47
24052451-2	2014	5,10-methylenetetrahydrofolate reductase (MTHFR) is a folate-dependent enzyme that catalyzed remethylation of homocysteine (Hcy) and the MTHFR C677T polymorphism makes the MTHFR enzyme thermolabile causing hyperhomocysteinemia.	Folic Acid	24-30	methylenetetrahydrofolate reductase	Homo sapiens	137-142
24052451-2	2014	5,10-methylenetetrahydrofolate reductase (MTHFR) is a folate-dependent enzyme that catalyzed remethylation of homocysteine (Hcy) and the MTHFR C677T polymorphism makes the MTHFR enzyme thermolabile causing hyperhomocysteinemia.	Folic Acid	24-30	methylenetetrahydrofolate reductase	Homo sapiens	137-142
24393513-1	2013	This study examined associations between MTHFR C677T polymorphism and serum folate concentrations with the risk of esophageal precancerous lesions (EPL) and esophageal squamous cell carcinoma (ESCC).	Folic Acid	76-82	methylenetetrahydrofolate reductase	Homo sapiens	41-46
24393513-5	2013	The MTHFR genotype may further modify associations between serum folate concentrations and the risk of ESCC, but it was not significantly associated with the risk of EPL.	Folic Acid	65-71	methylenetetrahydrofolate reductase	Homo sapiens	4-9
24129496-3	2013	Studies concerning the association between C677T polymorphism in methylenetetrahydrofolate reductase (MTHFR), an important enzyme in folate metabolism, and ovarian cancer risk also resulted in no agreement.	Folic Acid	84-90	methylenetetrahydrofolate reductase	Homo sapiens	102-107
23846816-1	2013	Methylenetetrahydrofolate reductase (MTHFR) gene plays key roles not only in folate metabolism but also in carcinogenesis.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
24223914-11	2013	As mSHMT is a key player in folate metabolism, our data provides a novel link between arginine and folate metabolism in human breast cancer, both of which are critical for tumor cell proliferation.	Folic Acid	28-34	serine hydroxymethyltransferase 1 (soluble)	Mus musculus	3-8
24223914-11	2013	As mSHMT is a key player in folate metabolism, our data provides a novel link between arginine and folate metabolism in human breast cancer, both of which are critical for tumor cell proliferation.	Folic Acid	99-105	serine hydroxymethyltransferase 1 (soluble)	Mus musculus	3-8
23623989-0	2013	Reduced nerve growth factor levels in stress-related brain regions of folate-deficient mice.	Folic Acid	70-76	nerve growth factor	Mus musculus	8-27
23623989-4	2013	However, the effects of folate deficiency on the expression of NGF and NT-3 in brain tissue have not yet been investigated.	Folic Acid	24-30	nerve growth factor	Mus musculus	63-66
23623989-6	2013	Independent of genotype, folate deficiency led to decreased NGF protein levels in the frontal cortex and amygdala.	Folic Acid	25-31	nerve growth factor	Mus musculus	60-63
23623989-9	2013	Altogether, the results of our study show that folate deficiency affects NGF levels in the frontal cortex, amygdala and hippocampus.	Folic Acid	47-53	nerve growth factor	Mus musculus	73-76
23623989-10	2013	The decrease in NGF content in the hippocampus in response to folate deficiency in Ung(-/-) mice may contribute to their phenotype of enhanced anxiety and despair-like behavior as well as to selective hippocampal neurodegeneration.	Folic Acid	62-68	nerve growth factor	Mus musculus	16-19
23670871-1	2013	BACKGROUND: This study examines gene-environment interaction between the MTHFR C667T polymorphism and folic acid in the etiology of orofacial clefts (OFC).	Folic Acid	102-112	methylenetetrahydrofolate reductase	Homo sapiens	73-78
23935743-2	2013	In order to prevent and mitigate the high-fat state that results from endothelial injury, this study examined the effect of folic acid (FA) and vitamin B12 (VB12) on the expression of PPARgamma and caspase-3 and -8 mRNA in the abdominal aortas of rats with hyperlipidemia.	Folic Acid	124-134	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	184-193
23332600-0	2013	DNA methyltransferase mediates dose-dependent stimulation of neural stem cell proliferation by folate.	Folic Acid	95-101	DNA methyltransferase 1	Homo sapiens	0-21
22983814-2	2013	Methyltetrahydrofolate reductase (MTHFR) gene mutation and low level of plasma vitamin B12 and folate could take part in the etiology of peripheral arterial disease (PAD).	Folic Acid	16-22	methylenetetrahydrofolate reductase	Homo sapiens	34-39
23657816-3	2013	Here we examine transient activation of TORC2 in response to chemically distinct chemoattractants, cAMP and folate, and suggest that TORC2 is regulated by adaptive, desensitizing responses to stimulatory ligands that are independent of downstream, feedback, or feedforward circuits.	Folic Acid	108-114	CREB regulated transcription coactivator 2	Homo sapiens	40-45
23657816-3	2013	Here we examine transient activation of TORC2 in response to chemically distinct chemoattractants, cAMP and folate, and suggest that TORC2 is regulated by adaptive, desensitizing responses to stimulatory ligands that are independent of downstream, feedback, or feedforward circuits.	Folic Acid	108-114	CREB regulated transcription coactivator 2	Homo sapiens	133-138
23657816-4	2013	Cells with acquired insensitivity to either folate or cAMP remain fully responsive to TORC2 activation if stimulated with the other ligand.	Folic Acid	44-50	CREB regulated transcription coactivator 2	Homo sapiens	86-91
23657816-5	2013	Thus TORC2 responses to cAMP or folate are not cross-inhibitory.	Folic Acid	32-38	CREB regulated transcription coactivator 2	Homo sapiens	5-10
23657816-6	2013	Using a series of signaling mutants, we show that folate and cAMP activate TORC2 through an identical GEF/Ras pathway but separate receptors and G protein couplings.	Folic Acid	50-56	CREB regulated transcription coactivator 2	Homo sapiens	75-80
23881414-7	2013	Supplementation of fpgs1 mutants with 5-formyltetrahydrofolate, a stable form of folate, rescues the defects in DNA methylation, histone H3K9 dimethylation, and chromatin silencing.	Folic Acid	56-62	DHFS-FPGS homolog B	Arabidopsis thaliana	19-24
23490201-1	2013	PURPOSE: Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the metabolism of folate.	Folic Acid	28-34	methylenetetrahydrofolate reductase	Homo sapiens	46-51
23112124-11	2013	CONCLUSION: Low dietary folate or Mthfr deficiency during pregnancy may result in adverse pregnancy outcomes by altering expression of the inflammatory mediators ApoAI and IFN-gamma in spleen and placenta.	Folic Acid	24-30	apolipoprotein A-I	Mus musculus	162-167
23456769-9	2013	Increases in RBC folate concentrations with 400 mug occurred within MTHFR gene mutation (C677T); and in the African American group.	Folic Acid	17-23	methylenetetrahydrofolate reductase	Homo sapiens	68-73
26105861-2	2013	INTRODUCTION: The MTHFR is a key enzyme in the folate cycle involved in homocysteine remethylation.	Folic Acid	47-53	methylenetetrahydrofolate reductase	Homo sapiens	18-23
22847291-1	2013	Methylenetetrahydrofolate reductase (MTHFR) is a central regulatory enzyme in the folate pathway.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
23183238-1	2013	Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme involved in folate metabolism.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
23212123-7	2013	However, VPA- or TCDD-induced P-glycoprotein transport was blocked in the PCFT-nullizygous mice, indicating that multiple neuroprotective mechanisms are compromised under folate-deficient conditions.	Folic Acid	171-177	solute carrier family 46, member 1	Mus musculus	74-78
23508410-8	2013	Compared with the MTHFR 677CC genotype, the CT and TT variants, both of which were related to lower folate concentrations, were associated with reduced prostate cancer risk [OR 0.82 (0.72-0.94) and OR 0.78 (0.64-0.94), respectively].	Folic Acid	100-106	methylenetetrahydrofolate reductase	Homo sapiens	18-23
23341251-12	2013	In the future, folate supplementation may prove to be an easy and effective clinical tool for prevention and/or treatment of metabolic syndrome associated with AAP treatment, but clearly more research needs to be done in this area.	Folic Acid	15-21	serpin family F member 2	Homo sapiens	160-163
23096011-0	2012	Quantitation of whole-blood total folate within defined MTHFR C677T genotype groups by isotope dilution-liquid chromatography-tandem mass spectrometry differs from microbiologic assay.	Folic Acid	34-40	methylenetetrahydrofolate reductase	Homo sapiens	56-61
23346725-4	2012	This article describes how two SNPs, both of which are methylenetetrahydrofolate reductase (MTHFR) variants, can affect the way an individual metabolizes folate, resulting in elevated homocysteine level, and why testing for these SNPs may be important.	Folic Acid	74-80	methylenetetrahydrofolate reductase	Homo sapiens	92-97
23171482-12	2012	On the contrary, the homozygous state for the 677T MTHFR variant may cause increased levels of homocysteine and/or an altered folate status and thus an increased risk for AMI, particularly in males.	Folic Acid	126-132	methylenetetrahydrofolate reductase	Homo sapiens	51-56
23155246-3	2012	In this case control study, we examined the combination of the polymorphisms MTHFR C677T and A1298C with MTR A2756G, where MTR, methionine synthase, is an important enzyme of the folate cycle in the methylation pathway.	Folic Acid	179-185	methylenetetrahydrofolate reductase	Homo sapiens	77-82
23155246-3	2012	In this case control study, we examined the combination of the polymorphisms MTHFR C677T and A1298C with MTR A2756G, where MTR, methionine synthase, is an important enzyme of the folate cycle in the methylation pathway.	Folic Acid	179-185	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	128-147
22826176-1	2012	Folate-conjugated and thermo-responsive poly((N-isopropylacrylamide)-co- acrylamide-co-(octadecyl acrylate)-co-(folate-(polyethylene glycol)-(acrylic acid))) (P(NIPA-co-AAm-co-ODA-co-FPA)) micelles with mean diameter of about 60 nm and lower critical solution temperature (LCST) of about 39 C were synthesized by free radical random copolymerization.	Folic Acid	0-6	zinc finger, C3HC type 1	Mus musculus	161-165
23059056-10	2012	The regression model revealed interactions between genotype and case-control status in the association of total plasma folate, total glutathione (GSH), and free GSH, to SNPs within the MGMT, 5,10-methenyltetrahydrofolate synthetase (MTHFS), and catalase (CAT) genes, respectively.	Folic Acid	119-125	O-6-methylguanine-DNA methyltransferase	Homo sapiens	185-189
22674380-3	2012	We obtained that the different biological processes of ABCB1 inhibited transport and signal network repressed carbon dioxide transport, ER to Golgi vesicle-mediated transport, folic acid transport, mitochondrion transport along microtubule, water transport, BMP signaling pathway, Ras protein signal transduction, transforming growth factor beta receptor signaling pathway in chimpanzee compared with the inhibited network of the human left cerebrum, as a result of inducing inhibition of mitochondrion transport along microtubule and BMP signal-induced cell shape in chimpanzee left cerebrum.	Folic Acid	176-186	ATP binding cassette subfamily B member 1	Pan troglodytes	55-60
23798054-4	2012	The most important genetic determinant of homocysteine in the general population is the common 677C   T variant in the gene encoding the folate-metabolising enzyme, MTHFR; homozygous individuals (TT genotype) have reduced enzyme activity and elevated plasma homocysteine concentrations.	Folic Acid	137-143	methylenetetrahydrofolate reductase	Homo sapiens	165-170
22729883-1	2012	Methylenetetrahydrofolate reductase (MTHFR) is believed to be involved in folate metabolism which plays a critical role in carcinogenesis.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
22136740-0	2012	Increasing the folic acid content of maternal or post-weaning diets induces differential changes in phosphoenolpyruvate carboxykinase mRNA expression and promoter methylation in rats.	Folic Acid	15-25	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	100-133
22136740-12	2012	Together, these findings show that both the period during the life course and sex influence the effect of increased exposure to folic acid on the epigenetic regulation of PEPCK and glucose homeostasis.	Folic Acid	128-138	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	171-176
22956622-4	2012	PEE restored the Al-induced inhibition of folate-dependent methionine synthase activity and the antioxidant enzymes (catalase, glutathione peroxidases and superoxide dismutase).	Folic Acid	42-48	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	59-78
23166529-3	2012	In the folate pathway, several genes are involved, including methylenetetrahydrofolate reductase (MTHFR), methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR), and methyltetrahydrofolate-homocysteine methyltransferase (MTR).	Folic Acid	7-13	methylenetetrahydrofolate reductase	Homo sapiens	61-96
23166529-3	2012	In the folate pathway, several genes are involved, including methylenetetrahydrofolate reductase (MTHFR), methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR), and methyltetrahydrofolate-homocysteine methyltransferase (MTR).	Folic Acid	7-13	methylenetetrahydrofolate reductase	Homo sapiens	98-103
19892394-1	2010	Glycine N-methyltransferase (GNMT) is a mediator in the methionine and folate cycles, and is responsible for the transfer of a methyl group from S-adenosylmethionine (SAM) to glycine forming S-adenosylhomocysteine (SAH) and sarcosine.	Folic Acid	71-77	glycine N-methyltransferase	Fundulus heteroclitus	0-27
19892394-1	2010	Glycine N-methyltransferase (GNMT) is a mediator in the methionine and folate cycles, and is responsible for the transfer of a methyl group from S-adenosylmethionine (SAM) to glycine forming S-adenosylhomocysteine (SAH) and sarcosine.	Folic Acid	71-77	glycine N-methyltransferase	Fundulus heteroclitus	29-33
20066615-1	2010	AIM: This study aimed to investigate the 677C &gt; T and 1298A &gt; C MTHFR gene polymorphisms and their metabolic effects on the levels of folate, vitamin B12 and homocysteine in the serum of Turkish spina bifida occulta (SBO) patients and healthy individuals in disease.	Folic Acid	140-146	methylenetetrahydrofolate reductase	Homo sapiens	70-75
19930673-1	2009	BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the metabolism of folate.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	49-54
19924280-7	2009	Children of mother who used folic acid had a 4.5% higher methylation of the IGF2 DMR than children who were not exposed to folic acid (49.5% vs. 47.4%; p = 0.014).	Folic Acid	28-38	WD repeat domain 20	Homo sapiens	81-84
19082889-2	2009	MTHFR plays a central role in biotransformation of folate to form S-adenosylmethionine, the universal methyl donor in cells and affects DNA methylation status.	Folic Acid	51-57	methylenetetrahydrofolate reductase	Homo sapiens	0-5
19666701-11	2009	In conclusion, vitamin D(3) and VDR increase intestinal PCFT expression, resulting in enhanced cellular folate uptake.	Folic Acid	104-110	vitamin D receptor	Homo sapiens	32-35
19814618-2	2009	Methylene tetrahydrofolate reductase (MTHFR) plays an important role for folate metabolism and is also an important source for DNA methylation and DNA synthesis (nucleotide synthesis).	Folic Acid	20-26	methylenetetrahydrofolate reductase	Homo sapiens	38-43
19105199-8	2009	Our findings suggest that there is a potential gene-environment interaction on the risk of NTDs between maternal or offspring RFC1 GG genotype and maternal periconceptional intake of folic acid.	Folic Acid	183-193	replication factor C subunit 1	Homo sapiens	126-130
19571232-8	2009	Coexpression of DYNLRB1 with hRFC led to a significant (P &lt; 0.05) increase in folate uptake.	Folic Acid	81-87	dynein light chain roadblock-type 1	Homo sapiens	16-23
19571232-9	2009	On the other hand, inhibiting the endogenous DYNLRB1 with gene-specific small interfering RNA or pharmacologically with a specific inhibitor (vanadate) led to a significant (P &lt; 0.05) decrease in folate uptake.	Folic Acid	199-205	dynein light chain roadblock-type 1	Homo sapiens	45-52
19288150-10	2009	RESULTS: A significant reduction in diffuse GC risk was observed for MTHFR 677 TT genotype among individuals with high consumption of folate (OR = 0.23; 95% CI 0.06-0.84), choline (OR = 0.55; 95% CI 0.33-0.9) and Vitamin B(6) (OR = 0.59; 95% CI 0.36-0.96) compared to MTHFR 677 CC + CT carriers.	Folic Acid	134-140	methylenetetrahydrofolate reductase	Homo sapiens	69-74
19288150-10	2009	RESULTS: A significant reduction in diffuse GC risk was observed for MTHFR 677 TT genotype among individuals with high consumption of folate (OR = 0.23; 95% CI 0.06-0.84), choline (OR = 0.55; 95% CI 0.33-0.9) and Vitamin B(6) (OR = 0.59; 95% CI 0.36-0.96) compared to MTHFR 677 CC + CT carriers.	Folic Acid	134-140	methylenetetrahydrofolate reductase	Homo sapiens	268-273
19288150-12	2009	In contrast, carriers of the MTHFR 677 TT genotype with a low consumption of folate had a significant increased risk of intestinal GC (OR = 1.88 95% CI 1.02-3.47).	Folic Acid	77-83	methylenetetrahydrofolate reductase	Homo sapiens	29-34
19215022-8	2009	Folate-deficient placentae had decreased ApoA-I expression, and there was a trend toward a negative correlation between ApoA-I expression with maternal homocysteine concentrations.	Folic Acid	0-6	apolipoprotein A-I	Mus musculus	41-47
19215022-8	2009	Folate-deficient placentae had decreased ApoA-I expression, and there was a trend toward a negative correlation between ApoA-I expression with maternal homocysteine concentrations.	Folic Acid	0-6	apolipoprotein A-I	Mus musculus	120-126
19174154-7	2009	In contrast, each weakly inhibits other enzymes of folate metabolism relevant to rheumatoid arthritis therapy (thymidylate synthase (EC 2.1.1.45), two formyltransferases of purine biosynthesis (EC 2.1.2.2 and EC 2.1.2.3), and 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)).	Folic Acid	51-57	methylenetetrahydrofolate reductase	Homo sapiens	231-266
20298385-2	2009	However, there have been conflicting reports on the potential association between atopic disease and a common polymorphism of the methylene-tetrahydrofolate reductase (MTHFR)-gene, a well-known marker of impaired folate metabolism.	Folic Acid	150-156	methylenetetrahydrofolate reductase	Homo sapiens	168-173
19249419-2	2009	Many receive nitrous oxide, which impairs methionine synthase, thus inhibiting folate synthesis and increasing postoperative homocysteine levels.	Folic Acid	79-85	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	42-61
19176749-11	2009	Folate depletion in normal intestine may trigger neoplasia through increased DNA damage and defective apoptosis; upregulation of CD44 and gelsolin, and the mitochondrial apoptotic pathway are implicated.	Folic Acid	0-6	CD44 antigen	Mus musculus	129-133
18715139-10	2009	The association between MTHFR genotype and spine BMD was attenuated particularly in girls by high maternal dietary intakes of vitamin B(6) and folate during pregnancy but not by child dietary intakes at 7 yr. To the extent that these findings reflect known influences of C677T MTHFR genotype on plasma homocysteine levels, our results suggest that the latter is an important regulator of spinal BMD in childhood.	Folic Acid	143-149	methylenetetrahydrofolate reductase	Homo sapiens	24-29
19056652-0	2009	Clinical utility of genotyping the 677C&gt;T variant of methylenetetrahydrofolate reductase in humans is decreased in the post-folic acid fortification era.	Folic Acid	127-137	methylenetetrahydrofolate reductase	Homo sapiens	56-91
19838916-1	2009	We investigated associations among intake of folate, vitamin B2, vitamin B6, vitamin B12, and polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MTR) genes and breast cancer risk in a Japanese population.	Folic Acid	45-51	methylenetetrahydrofolate reductase	Homo sapiens	153-158
19838916-1	2009	We investigated associations among intake of folate, vitamin B2, vitamin B6, vitamin B12, and polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MTR) genes and breast cancer risk in a Japanese population.	Folic Acid	45-51	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	164-183
18823966-1	2008	BACKGROUND: The methylenetetrahydrofolate reductase (MTHFR), glutamate carboxypeptidase II (GCPII) and reduced folate carrier (RFC1) gene polymorphisms were associated with folate status.	Folic Acid	35-41	methylenetetrahydrofolate reductase	Homo sapiens	53-58
18823966-1	2008	BACKGROUND: The methylenetetrahydrofolate reductase (MTHFR), glutamate carboxypeptidase II (GCPII) and reduced folate carrier (RFC1) gene polymorphisms were associated with folate status.	Folic Acid	111-117	replication factor C subunit 1	Homo sapiens	127-131
25855835-19	2008	MTHFR GENE POLYMORPHISMS AND RESPONSE TO CHEMOTHERAPY: Limited data preclude making meaningful inferences about the relationship between common variants in MTHFR and chemotherapy of the folate metabolic pathway.	Folic Acid	186-192	methylenetetrahydrofolate reductase	Homo sapiens	0-5
25855835-19	2008	MTHFR GENE POLYMORPHISMS AND RESPONSE TO CHEMOTHERAPY: Limited data preclude making meaningful inferences about the relationship between common variants in MTHFR and chemotherapy of the folate metabolic pathway.	Folic Acid	186-192	methylenetetrahydrofolate reductase	Homo sapiens	156-161
18987184-4	2008	Here, we show that folate deprivation in neuroblastoma cells induces downregulation of PP2A leucine carboxyl methyltransferase-1 (LCMT-1) expression, resulting in progressive accumulation of newly synthesized demethylated PP2A pools, concomitant loss of B(alpha), and ultimately cell death.	Folic Acid	19-25	protein phosphatase 2, regulatory subunit A, alpha	Mus musculus	87-91
18987184-4	2008	Here, we show that folate deprivation in neuroblastoma cells induces downregulation of PP2A leucine carboxyl methyltransferase-1 (LCMT-1) expression, resulting in progressive accumulation of newly synthesized demethylated PP2A pools, concomitant loss of B(alpha), and ultimately cell death.	Folic Acid	19-25	protein phosphatase 2, regulatory subunit A, alpha	Mus musculus	222-226
18987184-11	2008	They establish LCMT-1- and B(alpha)-containing PP2A holoenzymes as key mediators of the role of folate in the brain.	Folic Acid	96-102	protein phosphatase 2, regulatory subunit A, alpha	Mus musculus	47-51
18996879-11	2008	CONCLUSION: These results show an association between the C677T MTHFR variant and different folate intakes on risk of CRC.	Folic Acid	92-98	methylenetetrahydrofolate reductase	Homo sapiens	64-69
19091662-1	2008	Plasmatic homocysteine concentration depends mostly on 5,10 methylene tetrahydrofolate reductase (MTHFR) polymorphisms, a key enzyme in folate metabolism.	Folic Acid	80-86	methylenetetrahydrofolate reductase	Homo sapiens	98-103
19080826-8	2008	Serum folate concentration decreased significantly with the mutation of the C677T genotype for MTHFR.	Folic Acid	6-12	methylenetetrahydrofolate reductase	Homo sapiens	95-100
19080826-9	2008	Prevalence of deficits of folate (&lt; 5.3 nmol/l) was 23.8% and raised significantly with the mutation of the C677T genotype for MTHFR: 18.8% for CC, 20.4% for CT, and 46.7% for TT.	Folic Acid	26-32	methylenetetrahydrofolate reductase	Homo sapiens	130-135
19080826-11	2008	CONCLUSIONS: Homozygosis mutation in C677T genotype of the enzyme MTHFR induces lower folate levels, mainly in girls after menstruation.	Folic Acid	86-92	methylenetetrahydrofolate reductase	Homo sapiens	66-71
18842806-6	2008	DESIGN: Thirteen single nucleotide polymorphisms (SNPs) in genes involved in folate uptake and metabolism, including folate hydrolase (FOLH1), folate polyglutamate synthase (FPGS), gamma-glutamyl hydrolase (GGH), methylene tetrahydrofolate reductase (MTHFR), methionine synthase (MTR), proton-coupled folate transporter (PCFT), and reduced folate carrier (RFC1), were studied in a cohort of 991 individuals.	Folic Acid	77-83	methylenetetrahydrofolate reductase	Homo sapiens	213-249
18842806-6	2008	DESIGN: Thirteen single nucleotide polymorphisms (SNPs) in genes involved in folate uptake and metabolism, including folate hydrolase (FOLH1), folate polyglutamate synthase (FPGS), gamma-glutamyl hydrolase (GGH), methylene tetrahydrofolate reductase (MTHFR), methionine synthase (MTR), proton-coupled folate transporter (PCFT), and reduced folate carrier (RFC1), were studied in a cohort of 991 individuals.	Folic Acid	77-83	methylenetetrahydrofolate reductase	Homo sapiens	251-256
18842806-6	2008	DESIGN: Thirteen single nucleotide polymorphisms (SNPs) in genes involved in folate uptake and metabolism, including folate hydrolase (FOLH1), folate polyglutamate synthase (FPGS), gamma-glutamyl hydrolase (GGH), methylene tetrahydrofolate reductase (MTHFR), methionine synthase (MTR), proton-coupled folate transporter (PCFT), and reduced folate carrier (RFC1), were studied in a cohort of 991 individuals.	Folic Acid	77-83	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	259-278
18842806-6	2008	DESIGN: Thirteen single nucleotide polymorphisms (SNPs) in genes involved in folate uptake and metabolism, including folate hydrolase (FOLH1), folate polyglutamate synthase (FPGS), gamma-glutamyl hydrolase (GGH), methylene tetrahydrofolate reductase (MTHFR), methionine synthase (MTR), proton-coupled folate transporter (PCFT), and reduced folate carrier (RFC1), were studied in a cohort of 991 individuals.	Folic Acid	77-83	replication factor C subunit 1	Homo sapiens	356-360
18842806-7	2008	RESULTS: The MTHFR 677TT genotype was associated with increased plasma homocysteine and decreased plasma folate.	Folic Acid	105-111	methylenetetrahydrofolate reductase	Homo sapiens	13-18
19031955-3	2008	Methylenetetrahydrofolate reductase (MTHFR) has a key role in the folate cycle.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
18830030-5	2008	To all pregnant women Fraxiparin and vitamins of B group was appointed during pregnancy period; at presence of MTHFR a folic acid was appointed in addition.	Folic Acid	119-129	methylenetetrahydrofolate reductase	Homo sapiens	111-116
18629538-2	2008	We assessed whether the reduced folate carrier [NM_194255.1: c.80A--&gt;G (i.e., p.His27Arg)] (RFC-1) polymorphism was associated with placental abruption, and evaluated if maternal smoking modified the association between plasma folate and abruption.	Folic Acid	32-38	replication factor C subunit 1	Homo sapiens	95-100
18781847-1	2008	The 5,10-methylenetetrahydrofolate reductase (MTHFR) is a key enzyme for intracellular folate homeostasis and metabolism.	Folic Acid	28-34	methylenetetrahydrofolate reductase	Homo sapiens	46-51
18180190-9	2008	Among males, those with the MTHFR 677TT genotype appear to be at the highest risk and to be the most vulnerable to factors (e.g. smoking, low RBC folate) that are associated with homocysteine raising effects.	Folic Acid	146-152	methylenetetrahydrofolate reductase	Homo sapiens	28-33
18234410-6	2008	The C677T variant of MTHFR gene can also lead to hyperhomocysteinemia particularly when serum folate level is decreased.	Folic Acid	94-100	methylenetetrahydrofolate reductase	Homo sapiens	21-26
18074111-3	2008	A common mutation (677C--&gt;T) in the gene coding for MTHFR has been reported to reduce the enzymatic activity and is associated with elevated levels of Hcy, especially in subjects with low folate intake.	Folic Acid	191-197	methylenetetrahydrofolate reductase	Homo sapiens	55-60
18174236-3	2008	Functional polymorphisms in genes encoding one-carbon metabolism enzymes, methylenetetrahydrofolate reductase (MTHFR C677T), methionine synthase (MTR A2756G), methionine synthase reductase (MTRR A66G) and thymidylate synthase (TS), influence folate metabolism, but epidemiological studies have yielded inconsistent findings.	Folic Acid	93-99	methylenetetrahydrofolate reductase	Homo sapiens	111-116
18174236-8	2008	In combination analysis, a significantly elevated OR was found among postmenopausal women with the MTHFR 677TT genotype and lower intake of dietary folate compared with those with 677CC genotype and adequate folate consumption (OR = 2.80, 95% CI: 1.11-7.07).	Folic Acid	148-154	methylenetetrahydrofolate reductase	Homo sapiens	99-104
17963764-6	2008	The MTHFR T677T genotype increased the risk for placental abruption 4.8 times despite folate supplements, and normal serum folate and B(12) levels.	Folic Acid	86-92	methylenetetrahydrofolate reductase	Homo sapiens	4-9
17963764-6	2008	The MTHFR T677T genotype increased the risk for placental abruption 4.8 times despite folate supplements, and normal serum folate and B(12) levels.	Folic Acid	123-129	methylenetetrahydrofolate reductase	Homo sapiens	4-9
17983788-2	2008	In addition to its generalized role as a folate transporter, RFC provides specialized tissue functions including absorption across intestinal/colonic epithelia, transport across the basolateral membrane of renal proximal tubules, transplacental transport of folates, and folate transport across the blood-brain barrier.	Folic Acid	258-265	solute carrier family 19 (folate transporter), member 1	Mus musculus	61-64
17983788-2	2008	In addition to its generalized role as a folate transporter, RFC provides specialized tissue functions including absorption across intestinal/colonic epithelia, transport across the basolateral membrane of renal proximal tubules, transplacental transport of folates, and folate transport across the blood-brain barrier.	Folic Acid	41-47	solute carrier family 19 (folate transporter), member 1	Mus musculus	61-64
18714149-8	2008	Adolescents with the homozygous variant of methylenetetrahydrofolate reductase displayed significantly higher homocysteine and lower serum folate: normal 5.73 (3.09-10.73) ng/ml serum folate, 7.57 (4.94-12.94) micromol/l homocysteine; homozygous 4.10 (2.75-7.88) ng/ml serum folate, 10.83 (7.00-22.82) micromol/l homocysteine.	Folic Acid	139-145	methylenetetrahydrofolate reductase	Homo sapiens	43-78
18714149-8	2008	Adolescents with the homozygous variant of methylenetetrahydrofolate reductase displayed significantly higher homocysteine and lower serum folate: normal 5.73 (3.09-10.73) ng/ml serum folate, 7.57 (4.94-12.94) micromol/l homocysteine; homozygous 4.10 (2.75-7.88) ng/ml serum folate, 10.83 (7.00-22.82) micromol/l homocysteine.	Folic Acid	139-145	methylenetetrahydrofolate reductase	Homo sapiens	43-78
17543893-12	2008	Further, the biochemical interaction of low serum folate with 677T-variant MTHFR may induce downstream effects salient to the expression of negative symptoms.	Folic Acid	50-56	methylenetetrahydrofolate reductase	Homo sapiens	75-80
33802362-4	2021	This study aimed to analyze the association between the maternal MTHFR(677)C>T genetic polymorphism and anthropometry at birth in a population with adequate folate consumption.	Folic Acid	157-163	methylenetetrahydrofolate reductase	Homo sapiens	65-70
18844488-2	2008	Methionine synthase (MS), a vitamin B(12)-dependent enzyme, catalyses the remethylation of homocysteine to methionine using a methyl group donated by 5-methyltetra-hydrofolate, which is the major circulating form of folate in the body.	Folic Acid	169-175	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	0-19
18844488-2	2008	Methionine synthase (MS), a vitamin B(12)-dependent enzyme, catalyses the remethylation of homocysteine to methionine using a methyl group donated by 5-methyltetra-hydrofolate, which is the major circulating form of folate in the body.	Folic Acid	169-175	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	21-23
32797715-3	2020	This strategically framed TTNV is chemically conjugated with folic acid and hyaluronic acid as a dual-targeting entity to promote folate receptor (FR) mediated cancer cells and CD44 mediated CSC uptake, respectively.	Folic Acid	61-71	CD44 molecule (Indian blood group)	Homo sapiens	177-181
18844488-3	2008	Functional genetic variants of the MS may alter tHcy as well as folate levels which are independent risk factors for CAD.	Folic Acid	64-70	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	35-37
18844488-4	2008	The influence of a common genetic polymorphism 2756A&gt;G of the MS gene (MTR) on plasma tHcy, folate and vitamin B(12) levels and its relation to the risk of myocardial infarction (MI) in a Tunisian case-control study was investigated.	Folic Acid	95-101	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	65-67
16002796-3	2005	OBJECTIVE: The effect of folic acid supplementation on blood pressure and large artery stiffness was examined in relation to methylenetetrahydrofolate reductase (MTHFR) genotype.	Folic Acid	25-35	methylenetetrahydrofolate reductase	Homo sapiens	125-160
18957721-8	2008	Thus, we conclude that the C677T MTHFR polymorphism, responsible for a reduction of the MTHFR activity in folate metabolism, is not a major genetic susceptibility factor for migraine in the Portuguese population.	Folic Acid	106-112	methylenetetrahydrofolate reductase	Homo sapiens	33-38
18957721-8	2008	Thus, we conclude that the C677T MTHFR polymorphism, responsible for a reduction of the MTHFR activity in folate metabolism, is not a major genetic susceptibility factor for migraine in the Portuguese population.	Folic Acid	106-112	methylenetetrahydrofolate reductase	Homo sapiens	88-93
19096127-2	2008	With the purpose of evaluating this relationship, we compared the frequencies of 677C&gt;T and 1298A&gt;C polymorphisms in the methylenetetrahydrofolate reductase gene (MTHFR) and 66A&gt;G in the methionine synthase reductase gene (MTRR) between 103 young mothers of Down syndrome (DS) individuals and 108 control mothers, whose offspring was karyotypically normal, correlating it with an estimative of folate and - related micronutrients levels intake.	Folic Acid	146-152	methylenetetrahydrofolate reductase	Homo sapiens	169-174
16002796-3	2005	OBJECTIVE: The effect of folic acid supplementation on blood pressure and large artery stiffness was examined in relation to methylenetetrahydrofolate reductase (MTHFR) genotype.	Folic Acid	25-35	methylenetetrahydrofolate reductase	Homo sapiens	162-167
18642144-8	2008	The mammalian NAT enzymes are involved in metabolism of drugs and carcinogens but there is growing evidence, including from transgenic mice, that human NAT1 has an endogenous role in folate degradation.	Folic Acid	183-189	bromodomain containing 2	Homo sapiens	14-17
16002796-9	2005	MTHFR genotype CC homozygotes (without the 677C--&gt;T polymorphism) with normal blood pressure had a larger reduction in homocysteine concentrations in response to folic acid than did T allele carriers.	Folic Acid	165-175	methylenetetrahydrofolate reductase	Homo sapiens	0-5
34686102-11	2022	It might be helpful as nuclear and optical imaging agents for lung cancers that overexpress FRs and GRPR and as a specific target for radiation therapy if combined with folate-bombesin.	Folic Acid	169-175	gastrin releasing peptide	Homo sapiens	176-184
18409008-1	2008	5,10-methylenetetrahydrofolate reductase (MTHFR) is an important enzyme in folate metabolism.	Folic Acid	24-30	methylenetetrahydrofolate reductase	Homo sapiens	42-47
18156406-1	2008	Since the establishment of the 1998 folate recommended dietary allowance (RDA), the methylenetetrahydrofolate reductase (MTHFR) 677C--&gt;T variant has emerged as a strong modifier of folate status.	Folic Acid	36-42	methylenetetrahydrofolate reductase	Homo sapiens	84-119
18156406-1	2008	Since the establishment of the 1998 folate recommended dietary allowance (RDA), the methylenetetrahydrofolate reductase (MTHFR) 677C--&gt;T variant has emerged as a strong modifier of folate status.	Folic Acid	36-42	methylenetetrahydrofolate reductase	Homo sapiens	121-126
34757229-0	2022	Folate-mediated targeted PLK1 inhibition therapy for ovarian cancer: A comparative study of molecular inhibitors and siRNA therapeutics.	Folic Acid	0-6	polo like kinase 1	Homo sapiens	25-29
18156406-1	2008	Since the establishment of the 1998 folate recommended dietary allowance (RDA), the methylenetetrahydrofolate reductase (MTHFR) 677C--&gt;T variant has emerged as a strong modifier of folate status.	Folic Acid	103-109	methylenetetrahydrofolate reductase	Homo sapiens	121-126
34755744-4	2021	By loading DiR into the hydrophobic domain of folic acid-icodextrin-polycaprolactone (FA-ICO-PCL, FIP) and cisplatin-icodextrin-polycaprolactone (Pt-ICO-PCL, PtIP) co-assembly, the resultant DiR@(PtIP + FIP) (DPtFIP) NPs had a diameter of around 70 nm and showed excellent tumor targeting ability and negligible side effects.	Folic Acid	46-56	upstream transcription factor 2, c-fos interacting	Homo sapiens	98-101
34755744-4	2021	By loading DiR into the hydrophobic domain of folic acid-icodextrin-polycaprolactone (FA-ICO-PCL, FIP) and cisplatin-icodextrin-polycaprolactone (Pt-ICO-PCL, PtIP) co-assembly, the resultant DiR@(PtIP + FIP) (DPtFIP) NPs had a diameter of around 70 nm and showed excellent tumor targeting ability and negligible side effects.	Folic Acid	46-56	upstream transcription factor 2, c-fos interacting	Homo sapiens	203-206
34369004-1	2021	BACKGROUND: The 5,10-methylenetetrahydrofolate reductase (MTHFR) is an important enzyme of folate and methionine metabolism, which is expressed in human oocytes and preimplantation.	Folic Acid	91-97	methylenetetrahydrofolate reductase	Homo sapiens	16-56
17976958-2	2008	Reduced methylenetetrahydrofolate reductase (MTHFR) activity, resulting in aberrant folate metabolism and hyperhomocysteinemia, has been linked to cardiovascular disease and is unstudied in relation to AAP associated metabolic complications.	Folic Acid	27-33	methylenetetrahydrofolate reductase	Homo sapiens	45-50
19172696-0	2008	The reduced folate carrier (RFC1) 80G &gt; A and folate hydrolase 1 (FOLH1) 1561C &gt; T polymorphisms and the risk of colorectal cancer: a nested case-referent study.	Folic Acid	12-18	replication factor C subunit 1	Homo sapiens	28-32
19172696-2	2008	In this nested case-referent study, we related two such polymorphisms, reduced folate carrier (RFC1) 80G &gt; A and folate hydrolase 1 (FOLH1) 1561C &gt; T, to the risk of colorectal cancer, taking into account pre-diagnostic plasma folate and total homocysteine concentrations and the MTHFR 677C &gt; T polymorphism, which were analysed in a previous study.	Folic Acid	79-85	replication factor C subunit 1	Homo sapiens	95-99
19172696-2	2008	In this nested case-referent study, we related two such polymorphisms, reduced folate carrier (RFC1) 80G &gt; A and folate hydrolase 1 (FOLH1) 1561C &gt; T, to the risk of colorectal cancer, taking into account pre-diagnostic plasma folate and total homocysteine concentrations and the MTHFR 677C &gt; T polymorphism, which were analysed in a previous study.	Folic Acid	79-85	methylenetetrahydrofolate reductase	Homo sapiens	286-291
34369004-1	2021	BACKGROUND: The 5,10-methylenetetrahydrofolate reductase (MTHFR) is an important enzyme of folate and methionine metabolism, which is expressed in human oocytes and preimplantation.	Folic Acid	91-97	methylenetetrahydrofolate reductase	Homo sapiens	58-63
34421310-10	2021	Pathway enrichment analysis indicated that MTHFD2 high expression significantly and positively participated in the pathway of one carbon pool by folate (all P<0.05).	Folic Acid	145-151	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	Homo sapiens	43-49
18006931-1	2007	Previous studies have shown inconsistent associations of folate intake and polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene with gastric cancer risk.	Folic Acid	57-63	methylenetetrahydrofolate reductase	Homo sapiens	133-138
17615259-2	2007	Two folate transporters (folate receptor, FR, and Reduced Folate Carrier, hRFC1) are involved in the cell uptake of folate.	Folic Acid	4-10	replication factor C subunit 1	Homo sapiens	74-79
17904970-11	2007	Plasma homocysteine and vitamin B12, but not folate, concentrations were elevated in cases compared with control subjects among women with the wild-type genotype of MTHFR 677C--&gt;T (P = .039 for homocysteine; P = .048 for B12; P = .224 for folate).	Folic Acid	242-248	methylenetetrahydrofolate reductase	Homo sapiens	165-170
17561949-3	2007	Four MTHFR polymorphism groups were identified with the following tHcy (micromol/L) and folate (nmol/L) levels (mean +/- SD): (a) MTHFR677TT/1298AA, 24 patients, 36.0 +/- 4.8, 4.1 +/- 0.7; (b) MTHFR677CT/1298AC 27.1 +/- 2.7, 5.3 +/- 1.0 (n = 15); (c) MTHFR677CT/1298AA 16.6 +/- 3.6, 6.8 +/- 1.0 (n = 11), all taking enzyme-inducing AEDs; and (d) MTHFR677TT/1298AA 24.5 +/- 3.2, 5.6 +/- 1.1 (n = 9), treated with new AEDs.	Folic Acid	88-94	methylenetetrahydrofolate reductase	Homo sapiens	5-10
17418558-0	2007	Red blood cell folate vitamer distribution in healthy subjects is determined by the methylenetetrahydrofolate reductase C677T polymorphism and by the total folate status.	Folic Acid	15-21	methylenetetrahydrofolate reductase	Homo sapiens	84-119
17418558-14	2007	In addition, high total folate status may contribute to minor to moderate nonmethylfolate accumulation in MTHFR CC and CT subjects.	Folic Acid	24-30	methylenetetrahydrofolate reductase	Homo sapiens	106-111
17228344-9	2007	However, with stratification by mean value of age and B-group vitamins concentrations, we found that at advanced age, lower plasma folate and vitamin B(12) were three risk factors involved in the enhancing effect of the MTHFR 677TT genotype on the increase of plasma Hcy and carotid IMT.	Folic Acid	131-137	methylenetetrahydrofolate reductase	Homo sapiens	220-225
17228344-10	2007	CONCLUSION: MTHFR 677TT-related carotid atherosclerosis was only identified in healthy elderly subjects with lower level of plasma folate and vitamin B(12).	Folic Acid	131-137	methylenetetrahydrofolate reductase	Homo sapiens	12-17
17111187-2	2007	The methylenetetrahydrofolate reductase (MTHFR) gene, involved in folate metabolism, is polymorphic in humans.	Folic Acid	23-29	methylenetetrahydrofolate reductase	Homo sapiens	41-46
17582128-8	2007	In cows fed folic acid supplements, supplementary B12 increased plasma glucose and alanine, tended to decrease plasma biotin, and decreased Km of the methylmalonyl-coenzyme A mutase in hepatic tissues following addition of deoxyadenosylcobalamin, whereas it had no effect when cows were not fed folic acid supplements.	Folic Acid	295-305	methylmalonyl-CoA mutase	Bos taurus	150-181
17591934-1	2007	The disorders of folate metabolism caused by methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms may lead to several disease states including coronary heart disease, venous thrombosis, and several types of cancer.	Folic Acid	17-23	methylenetetrahydrofolate reductase	Homo sapiens	45-80
17591934-1	2007	The disorders of folate metabolism caused by methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms may lead to several disease states including coronary heart disease, venous thrombosis, and several types of cancer.	Folic Acid	17-23	methylenetetrahydrofolate reductase	Homo sapiens	82-87
17389614-8	2007	When stratified by dietary intake of folate, the effect of the MTHFR 677T variant was more prominent among subjects with low intake of folate: the ORs for 677T/677T genotype among subjects with the lowest decile were 2.60 (95% CI = 1.39-4.88) and 4.14 (95% CI = 1.47-11.7) for lung and upper aero-digestive tract cancer, respectively.	Folic Acid	37-43	probable methylenetetrahydrofolate reductase	Nicotiana tabacum	63-68
17457696-8	2007	This study indicates that the sequence alteration c.677C&gt;T combined with severe MTHFR mutations in compound heterozygous state may lead to moderate biochemical and clinical abnormalities exceeding those attributed to the c.677TT genotype and might require in addition to folate substitution further therapy to normalize homocysteine levels.	Folic Acid	274-280	methylenetetrahydrofolate reductase	Homo sapiens	83-88
17303386-10	2007	CONCLUSION: A further inactivation of polymorphic MTHFR by low riboflavin status and a resulting shift in the folate metabolic pathway toward DNA synthesis may explain these observations.	Folic Acid	110-116	methylenetetrahydrofolate reductase	Homo sapiens	50-55
17236128-1	2007	A high level of cytogenetic expression of the rare folate-sensitive fragile site FRA12A is significantly associated with mental retardation.	Folic Acid	51-57	fragile site, folic acid type, rare, fra(12)(q13.1)	Homo sapiens	81-87
17227731-2	2007	METHODS: We evaluated homocysteine, folic acid and vitamin B(12) concentrations, and the mutations 677C&gt;T and 1298A&gt;C in MTHFR, 844ins68 in CBS and 2756A&gt;G in MTR genes in 58 patients with congenital heart defects, 38 control subjects, and mothers of 49 patients and 26 controls.	Folic Acid	36-46	methylenetetrahydrofolate reductase	Homo sapiens	127-132
16950800-10	2007	This study suggests a possible role of the polymorphisms in MTHFR and VDR interacting with dietary intakes of folate and vitamin D in skin cancer development, especially for SCC.	Folic Acid	110-116	vitamin D receptor	Homo sapiens	70-73
17240315-5	2007	Polymorphisms in methlyene tetrahydrofolate reductase (MTHFR) (involved in folate metabolism), apolipoprotein E (Apo E) and ApoA1 (in cardiovascular disease), and leptin/leptin receptor (obesity) genes are some good examples for understanding basic nutrigenetics.	Folic Acid	37-43	methylenetetrahydrofolate reductase	Homo sapiens	55-60
16134079-2	2007	MTHFR is a key enzyme that regulates folate metabolism which has an important role in DNA synthesis, DNA repair and methylation.	Folic Acid	37-43	methylenetetrahydrofolate reductase	Homo sapiens	0-5
17684410-3	2007	We found that functional polymorphisms in methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS), two key enzymes involved in folate and methyl group metabolism, were significantly associated with increased risk of esophageal squamous cell carcinoma, gastric cardia carcinoma, and pancreatic carcinoma.	Folic Acid	61-67	methylenetetrahydrofolate reductase	Homo sapiens	79-84
34421310-12	2021	Our results assumed that MTHFD2 high expression might play a pivotal role in LGG through positively regulating pathway of one carbon pool by folate.	Folic Acid	141-147	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	Homo sapiens	25-31
34128976-1	2021	5, 10-Methylenetetrahydrofolate reductase (MTHFR) is a crucial enzyme in the folate metabolic pathway with a key role in generating methyl groups.	Folic Acid	77-83	methylenetetrahydrofolate reductase	Homo sapiens	43-48
17607914-3	2007	In esophageal carcinomas, a higher gene expression of methylenetetrahydrofolate reductase (MTHFR), an enzyme involved in folate metabolism, was more frequently found in responding patients.	Folic Acid	73-79	methylenetetrahydrofolate reductase	Homo sapiens	91-96
34160104-9	2021	Moreover, in two AKI mouse models, fibroblast-specific deletion of PKM2 blocked HGF signal activation and aggravated AKI after it was induced in mice via ischemia or folic acid.	Folic Acid	166-176	hepatocyte growth factor	Mus musculus	80-83
34204335-3	2021	OBJECTIVE: To determine if maternal dietary intake of folic acid (FA) is related to the methylation status (MS) of VSD-associated genes (AXIN1, MTHFR, TBX1, and TBX20).	Folic Acid	54-64	axin 1	Homo sapiens	137-142
16917939-10	2006	Differences in allele frequency and/or significant gene-gene interactions were found for relevant genes encoding the reduced folate carrier (RFC 80G &gt; A), transcobalamin II (TCN2 776G &gt; C), catechol-O-methyltransferase (COMT 472G &gt; A), methylenetetrahydrofolate reductase (MTHFR 677C &gt; T and 1298A &gt; C), and glutathione-S-transferase (GST M1).	Folic Acid	125-131	methylenetetrahydrofolate reductase	Homo sapiens	245-280
16917939-10	2006	Differences in allele frequency and/or significant gene-gene interactions were found for relevant genes encoding the reduced folate carrier (RFC 80G &gt; A), transcobalamin II (TCN2 776G &gt; C), catechol-O-methyltransferase (COMT 472G &gt; A), methylenetetrahydrofolate reductase (MTHFR 677C &gt; T and 1298A &gt; C), and glutathione-S-transferase (GST M1).	Folic Acid	125-131	methylenetetrahydrofolate reductase	Homo sapiens	282-287
34204335-3	2021	OBJECTIVE: To determine if maternal dietary intake of folic acid (FA) is related to the methylation status (MS) of VSD-associated genes (AXIN1, MTHFR, TBX1, and TBX20).	Folic Acid	54-64	methylenetetrahydrofolate reductase	Homo sapiens	144-149
16835399-4	2006	The activities of GNMT, phosphatidylethanolamine N-methyltransferase (PEMT), and betaine-homocysteine S-methyltransferase (BHMT) were increased about twofold in diabetic rat liver; folate deficiency resulted in the greatest elevation in GNMT activity.	Folic Acid	181-187	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	70-74
34289004-5	2021	RESULTS: Carriers of C/T and T/T genotypes of the MTHFR gene had higher levels of cholesterol and triglycerides and lower levels of vitamin B6 and folate.	Folic Acid	147-153	methylenetetrahydrofolate reductase	Homo sapiens	50-55
16944145-1	2006	Methylenetetrahydrofolate reductase (MTHFR) is one of the most critical enzyme in folic acid metabolism, and it converts 5,10-MTHF to 5-MTHF.	Folic Acid	82-92	methylenetetrahydrofolate reductase	Homo sapiens	0-35
34122714-3	2021	Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism.	Folic Acid	63-69	methylenetetrahydrofolate reductase	Homo sapiens	0-35
16944145-1	2006	Methylenetetrahydrofolate reductase (MTHFR) is one of the most critical enzyme in folic acid metabolism, and it converts 5,10-MTHF to 5-MTHF.	Folic Acid	82-92	methylenetetrahydrofolate reductase	Homo sapiens	37-42
16944145-5	2006	Because folate is the cornerstone in DNA synthesis, we analysed herein if the polymorphisms in MTHFR gene can alter the susceptibility of lymphoproliferative disease risk and if it has an effect on chemotherapy response.	Folic Acid	8-14	methylenetetrahydrofolate reductase	Homo sapiens	95-100
34122714-3	2021	Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism.	Folic Acid	63-69	methylenetetrahydrofolate reductase	Homo sapiens	37-42
17243563-8	2006	Total cholesterol, triglycerides, vitamin B12 and folate were statistically different in "all MTHFR genotypes" (p&lt;0.001, p&lt;0.01, p=0.044 and p=0.036, respectively), and in TC/TT (p&lt;0.001, p=0.003, p=0.030 and p=0.032, respectively) groups.	Folic Acid	50-56	methylenetetrahydrofolate reductase	Homo sapiens	94-99
34522719-1	2021	Methyltetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism, and its single nucleotide polymorphism (SNP) site C677T may be associated with gastrointestinal cancer.	Folic Acid	60-66	methylenetetrahydrofolate reductase	Homo sapiens	34-39
17243563-14	2006	In the group of patients with TC/TT MTHFR genotype, lower vitamin B12 and higher folate values were recorded.	Folic Acid	81-87	methylenetetrahydrofolate reductase	Homo sapiens	36-41
17201138-1	2006	BACKGROUND: 5,10-Methylenetetrahydrofolate reductase (MTHFR), a key enzyme in folate metabolism, plays a major role in the provision of methyl groups for DNA methylation; thymidylate synthase (TS) is a rate-limiting enzyme in the synthesis of dTMP and DNA repair.	Folic Acid	36-42	methylenetetrahydrofolate reductase	Homo sapiens	54-59
16950805-10	2006	Folic acid concentration significantly affected radiation-induced micronuclei (P &lt; 0.001): the increased incidence of radiation-induced micronuclei with low folic acid was mainly accounted for by carriers of the variant MTHFR allele (both homozygotes and heterozygotes), but the overall effect of genotype did not attain statistical significance.	Folic Acid	0-10	methylenetetrahydrofolate reductase	Homo sapiens	223-228
34169999-13	2021	CONCLUSION: We reported significant association between genetic alterations of folate metabolism (MTHFR, MTRR) and DNA repair mechanism (RAD54L) genes with the histopathological characteristics of the meningioma tumors.	Folic Acid	79-85	methylenetetrahydrofolate reductase	Homo sapiens	98-103
16950805-10	2006	Folic acid concentration significantly affected radiation-induced micronuclei (P &lt; 0.001): the increased incidence of radiation-induced micronuclei with low folic acid was mainly accounted for by carriers of the variant MTHFR allele (both homozygotes and heterozygotes), but the overall effect of genotype did not attain statistical significance.	Folic Acid	160-170	methylenetetrahydrofolate reductase	Homo sapiens	223-228
34169999-13	2021	CONCLUSION: We reported significant association between genetic alterations of folate metabolism (MTHFR, MTRR) and DNA repair mechanism (RAD54L) genes with the histopathological characteristics of the meningioma tumors.	Folic Acid	79-85	RAD54 like	Homo sapiens	137-143
16950805-12	2006	The effect of folic acid level on this end-point was modulated by the MTHFR genotype (P for interaction = 0.02), with TT cells grown at low folic acid concentration apparently resistant to the induction of radiation-induced bridges.	Folic Acid	14-24	methylenetetrahydrofolate reductase	Homo sapiens	70-75
35463099-0	2022	Association of MTHFR C677T (rs1801133) and A1298C (rs1801131) Polymorphisms with Serum Homocysteine, Folate and Vitamin B12 in Patients with Young Coronary Artery Disease.	Folic Acid	101-107	methylenetetrahydrofolate reductase	Homo sapiens	15-20
16936384-1	2006	BACKGROUND AND AIMS: In view of the prevailing controversy about the role of Methylenetetrahydrofolate reductase (MTHFR) C677T mutation in stroke and paucity of studies from India, this study has been undertaken to evaluate MTHFR C677T gene polymorphism in consecutive ischemic stroke patients and correlate these with folic acid, homocysteine (Hcy) and conventional risk factors.	Folic Acid	319-329	methylenetetrahydrofolate reductase	Homo sapiens	114-119
35463099-2	2022	The objective of this study was to evaluate the clinical usefulness of association between MTHFR C677T (rs1801133) and A1298C (rs1801131) polymorphisms with serum homocysteine, folate and vitamin B12 in addition to conventional cardiovascular risk factors in patients with young CAD.	Folic Acid	177-183	methylenetetrahydrofolate reductase	Homo sapiens	91-96
35349697-0	2022	Deacetylation of MTHFD2 by SIRT4 senses stress signal to inhibit cancer cell growth by remodeling folate metabolism.	Folic Acid	98-104	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	Homo sapiens	17-23
35349697-4	2022	Methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase 2 (MTHFD2) is one of the key enzymes in folate metabolism and its expression is highly increased in multiple human cancers.	Folic Acid	121-127	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	Homo sapiens	0-82
35349697-4	2022	Methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase 2 (MTHFD2) is one of the key enzymes in folate metabolism and its expression is highly increased in multiple human cancers.	Folic Acid	121-127	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	Homo sapiens	84-90
16953277-12	2006	Carriers of the methylenetetrahydrofolate reductase (MTHFR) 677T allele with CAD had significantly higher levels of anti-Nepsilon-Hcy-albumin before and during folic acid administration as compared to healthy subjects.	Folic Acid	160-170	methylenetetrahydrofolate reductase	Homo sapiens	16-51
16953277-12	2006	Carriers of the methylenetetrahydrofolate reductase (MTHFR) 677T allele with CAD had significantly higher levels of anti-Nepsilon-Hcy-albumin before and during folic acid administration as compared to healthy subjects.	Folic Acid	160-170	methylenetetrahydrofolate reductase	Homo sapiens	53-58
35349697-7	2022	K50 de-acetylation destabilizes MTHFD2 by elevating Cullin 3 (CUL3) E3 ligase-mediated proteasomal degradation in response to stressful stimuli of folate deprivation, leading to suppression of nicotinamide adenine dinucleotide phosphate (NADPH) production in tumor cells and accumulation of intracellular reactive oxygen species (ROS), which in turn inhibits the growth of breast cancer cells.	Folic Acid	147-153	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	Homo sapiens	32-38
35349697-8	2022	Collectively, our study reveals that SIRT4 senses folate availability to control MTHFD2 K50 acetylation and its protein stability, bridging nutrient/folate stress and cellular redox to act on cancer cell growth.	Folic Acid	50-56	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	Homo sapiens	81-87
35322363-0	2022	Folic acid alleviates lead acetate-mediated cardiotoxicity by down-regulating the expression levels of Nrf2, HO-1, GRP78, and CHOP proteins.	Folic Acid	0-10	heme oxygenase 1	Rattus norvegicus	109-113
35322363-0	2022	Folic acid alleviates lead acetate-mediated cardiotoxicity by down-regulating the expression levels of Nrf2, HO-1, GRP78, and CHOP proteins.	Folic Acid	0-10	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	115-120
16602006-7	2006	They found that the mother, who also had not supplemented her folic acid intake, had a secondarily altered folate status with an increased homocysteine level, suggesting that the homozygous TT mutation in the MTHFR gene in both mother and her child had contributed to the presentation of DS and a neural tube defect.	Folic Acid	107-113	methylenetetrahydrofolate reductase	Homo sapiens	209-214
2529254-3	1989	One possible explanation for this phenomenon is that low levels of dihydrofolate polyglutamates that accumulate in the presence of antifolates block thymidylate synthase to prevent depletion of reduced folate pools.	Folic Acid	74-80	thymidylate synthase	Mus musculus	149-169
16602006-12	2006	that the MTHFR 677TT could be a mutual genetic risk factor for the co-occurrence of trisomy 21 and midline defects, the risk of which may be reduced by periconceptional folic acid supplementation.	Folic Acid	169-179	methylenetetrahydrofolate reductase	Homo sapiens	9-14
2743307-2	1989	A radioenzymatic assay based upon entrapment of tissue 5,10-methylenetetrahydrofolate (CH2FH4), and other reduced folates after cycling to this form, into a stable ternary complex with thymidylate synthase and [3H]-5-fluoro-2"-deoxyuridine 5"-monophosphate was used to estimate reduced folates.	Folic Acid	114-121	thymidylate synthase	Mus musculus	185-205
16865747-10	2006	Hyperhomocysteinemia and the vitamin deficiencies presented by type 2 diabetic individuals, included with a heterozygous genotype for the G1793A mutation in the MTHFR gene, reached normal values by daily folic acid supplementation.	Folic Acid	204-214	methylenetetrahydrofolate reductase	Homo sapiens	161-166
16706930-1	2006	Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme involved in folate metabolism, DNA methylation and synthesis.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
2500271-2	1989	In an epileptic boy undergoing long-term treatment with valproic acid (VPA), 1.3 g/d, CBMZP, 0.9 g/d and folic acid, 7.5 mg/d, decreased activities of ALA-D and URO-S coincided with increased levels of erythrocyte protoporphyrin (EP) in the absence of Pb poisoning, iron depletion and erythropoietic protoporphyria.	Folic Acid	105-115	aminolevulinate dehydratase	Homo sapiens	151-156
16418743-12	2006	Supplementation of folic acid with vitamin B(12) may be preferable when the MTHFR 677T variant allele is prevalent.	Folic Acid	19-29	methylenetetrahydrofolate reductase	Homo sapiens	76-81
16596679-2	2006	The 80G&gt;A polymorphism of the reduced folate carrier gene (RFC-1) has been recently demonstrated to affect plasma folate and homocysteine levels, alone or in combination with the 677C&gt;T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene.	Folic Acid	41-47	replication factor C subunit 1	Homo sapiens	62-67
16596679-2	2006	The 80G&gt;A polymorphism of the reduced folate carrier gene (RFC-1) has been recently demonstrated to affect plasma folate and homocysteine levels, alone or in combination with the 677C&gt;T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene.	Folic Acid	41-47	methylenetetrahydrofolate reductase	Homo sapiens	212-247
16596679-2	2006	The 80G&gt;A polymorphism of the reduced folate carrier gene (RFC-1) has been recently demonstrated to affect plasma folate and homocysteine levels, alone or in combination with the 677C&gt;T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene.	Folic Acid	41-47	methylenetetrahydrofolate reductase	Homo sapiens	249-254
16641680-7	2006	These findings suggest that folate supplement may be beneficial to some schizophrenic patients with homocysteinemia due to the genetic defect of methylenetetrahydrofolate reductase.	Folic Acid	28-34	methylenetetrahydrofolate reductase	Homo sapiens	145-180
16681562-16	2006	Genotypic characteristics suggest that C(677)T MTHFR mutation confers a higher risk for stroke to both homozygous and heterozygous T allele carriers that cannot be ascribed solely to raised tHcy and/or lower folate status in CT subjects, nor to phenotypic expression of conventional risk factors for stroke.	Folic Acid	208-214	methylenetetrahydrofolate reductase	Homo sapiens	47-52
16613994-4	2006	METHODS: Polymorphisms of factor V 1691G--&gt;A, methylenetetrahydrofolate reductase (MTHFR) 677C --&gt; T and 1298A --&gt; C and plasma levels of total homocysteine, folate and vitamin B(12) were determined in blood samples collected in 1992-1993 from 5874 women aged 40-42 years, and linked with 14 474 pregnancies in the same women, recorded in the Medical Birth Registry of Norway, 1967-1996.	Folic Acid	68-74	methylenetetrahydrofolate reductase	Homo sapiens	86-91
16672082-3	2006	Since the identification of the first genetic risk factor of NTD, the C677T single-nucleotide polymorphism (SNP) in the methylenetetrahydrofolate reductase (MTHFR) gene, and the observation that elevated plasma homocysteine levels are associated with NTD, research has focused on genetic variation in genes encoding for enzymes of folate metabolism and the closely-related homocysteine metabolism.	Folic Acid	139-145	methylenetetrahydrofolate reductase	Homo sapiens	157-162
16586448-0	2006	Expression of folate pathway genes in the cartilage of Hoxd4 and Hoxc8 transgenic mice.	Folic Acid	14-20	homeobox D4	Mus musculus	55-60
16586448-0	2006	Expression of folate pathway genes in the cartilage of Hoxd4 and Hoxc8 transgenic mice.	Folic Acid	14-20	homeobox C8	Mus musculus	65-70
16586448-4	2006	We have also shown that Hoxd4 transgenic mice whose diets were supplemented with folate had their skeletal development restored.	Folic Acid	81-87	homeobox D4	Mus musculus	24-29
16586448-5	2006	Since folate is required for growth and differentiation of chondrocytes, we hypothesized that the beneficial effect of folate in Hoxd4 transgenic mice might indicate a local deficiency in folate utilization, possibly caused by deregulation of genes encoding folate transport proteins or folate metabolic enzymes.	Folic Acid	119-125	homeobox D4	Mus musculus	129-134
16586448-5	2006	Since folate is required for growth and differentiation of chondrocytes, we hypothesized that the beneficial effect of folate in Hoxd4 transgenic mice might indicate a local deficiency in folate utilization, possibly caused by deregulation of genes encoding folate transport proteins or folate metabolic enzymes.	Folic Acid	119-125	homeobox D4	Mus musculus	129-134
16586448-5	2006	Since folate is required for growth and differentiation of chondrocytes, we hypothesized that the beneficial effect of folate in Hoxd4 transgenic mice might indicate a local deficiency in folate utilization, possibly caused by deregulation of genes encoding folate transport proteins or folate metabolic enzymes.	Folic Acid	119-125	homeobox D4	Mus musculus	129-134
16586448-5	2006	Since folate is required for growth and differentiation of chondrocytes, we hypothesized that the beneficial effect of folate in Hoxd4 transgenic mice might indicate a local deficiency in folate utilization, possibly caused by deregulation of genes encoding folate transport proteins or folate metabolic enzymes.	Folic Acid	119-125	homeobox D4	Mus musculus	129-134
16538173-1	2006	5,10-Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme in the folate metabolic pathway.	Folic Acid	24-30	methylenetetrahydrofolate reductase	Homo sapiens	42-47
16522920-11	2006	CONCLUSION: Our data agree with the hypothesis of a gene-nutrient interaction between MTHFR 677C--&gt;T polymorphism and folate status that may confer a selective advantage of TT-homozygous genotype when dietary intake of folate is adequate, at least in the areas studied.	Folic Acid	121-127	methylenetetrahydrofolate reductase	Homo sapiens	86-91
16522920-11	2006	CONCLUSION: Our data agree with the hypothesis of a gene-nutrient interaction between MTHFR 677C--&gt;T polymorphism and folate status that may confer a selective advantage of TT-homozygous genotype when dietary intake of folate is adequate, at least in the areas studied.	Folic Acid	222-228	methylenetetrahydrofolate reductase	Homo sapiens	86-91
16512937-0	2006	Low folic acid status and its association with anaemia in urban adolescent girls and women of childbearing age in Sri Lanka.	Folic Acid	4-14	sorcin	Homo sapiens	114-117
16112698-9	2006	Folic acid also reduced VPA-induced alterations in p53, NF-kappaB, Pim-1, c-Myb, and Bax/Bcl-2 protein levels, while pantothenic acid prevented VPA-induced alterations in NF-kappaB, Pim-1, and c-Myb.	Folic Acid	0-10	BCL2-associated X protein	Mus musculus	85-88
16169148-1	2006	Altered maternal folate status and homozygous mutation in the methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) genes can promote chromosomal instability and non-dysjunction resulting in fetal trisomy 21.	Folic Acid	17-23	methylenetetrahydrofolate reductase	Homo sapiens	99-104
16234842-1	2006	OBJECTIVE: To explore the influence of gender, together with folate status, on the relation between the common methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and plasma total homocysteine (tHcy) concentrations in healthy children.	Folic Acid	61-67	methylenetetrahydrofolate reductase	Homo sapiens	148-153
16234842-12	2006	CONCLUSIONS: Under conditions of lower folate status (as estimated by either plasma concentration or reported dietary consumption), gender modifies the association of the MTHFR(C677T) polymorphism with tHcy concentrations in healthy children.	Folic Acid	39-45	methylenetetrahydrofolate reductase	Homo sapiens	171-176
16910166-2	2006	Mice lacking ApoE (ApoE -/- mice) upregulate the expression and activity of another enzyme, glutathione synthase (GS), when deprived of folate, in an apparent attempt to compensate for increased oxidative damage.	Folic Acid	136-142	glutathione synthetase	Mus musculus	92-112
16317155-4	2005	The role of folate in these processes may be modulated by genotype for the common C677T thermolabile variant of methylene tetrahydrofolate reductase (MTHFR), homozygosity for which is associated with lower enzyme activity, lower plasma and red blood cell folate, and elevated plasma homocysteine.	Folic Acid	12-18	methylenetetrahydrofolate reductase	Homo sapiens	112-148
16317155-4	2005	The role of folate in these processes may be modulated by genotype for the common C677T thermolabile variant of methylene tetrahydrofolate reductase (MTHFR), homozygosity for which is associated with lower enzyme activity, lower plasma and red blood cell folate, and elevated plasma homocysteine.	Folic Acid	12-18	methylenetetrahydrofolate reductase	Homo sapiens	150-155
16317155-6	2005	The MTHFR C677T polymorphism appears to interact with folate and riboflavin in modulating cancer risk in a manner that varies according to cancer site.	Folic Acid	54-60	methylenetetrahydrofolate reductase	Homo sapiens	4-9
16275406-3	2005	Methylenetetrahydrofolate reductase (MTHFR) gene mutations at nucleotides 677 and 1298 cause reduced MTHFR enzyme activity, which leads to increased homocysteine and reduced serum folate levels that are known to be involved in vascular impairment.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
16275406-3	2005	Methylenetetrahydrofolate reductase (MTHFR) gene mutations at nucleotides 677 and 1298 cause reduced MTHFR enzyme activity, which leads to increased homocysteine and reduced serum folate levels that are known to be involved in vascular impairment.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	101-106
16259797-2	2005	MTHFR C(677)T increases tHcy in association with low folate.	Folic Acid	53-59	methylenetetrahydrofolate reductase	Homo sapiens	0-5
16259797-8	2005	RESULTS: MTHFR TT predisposed to hyperhomocysteinaemia; this was increased in the presence of low folate (P&lt;0.05) and vitamin B(12) (P&lt;0.01).	Folic Acid	98-104	methylenetetrahydrofolate reductase	Homo sapiens	9-14
16334126-1	2005	BACKGROUND: Thymidylate synthase (TS) and methylenetetrahydrofolate reductase (MTHFR) play important roles in folate metabolism.	Folic Acid	61-67	methylenetetrahydrofolate reductase	Homo sapiens	79-84
16370225-2	2005	Recently, functionally significant SNPs in 5,10-methylenetetrahydrofolate reductase (MTHFR), a critical enzyme for intracellular folate homeostasis and metabolism, have been identified and characterized.	Folic Acid	67-73	methylenetetrahydrofolate reductase	Homo sapiens	85-90
16370225-3	2005	An emerging body of in vitro and clinical evidence suggests that these MTHFR SNPs may be an important pharmacogenetic determinant of predicting response to and toxicity of methotrexate and 5-fluorouracil-based cancer and anti-inflammatory treatments because of their well-defined and highly relevant biochemical effects on intracellular folate composition and one-carbon transfer reactions.	Folic Acid	337-343	methylenetetrahydrofolate reductase	Homo sapiens	71-76
16055441-8	2005	Also, the atfolt1 null mutant contains wild-type levels of folates in chloroplasts and preserves the enzymatic capacity to catalyze folate-dependent reactions in this subcellular compartment.	Folic Acid	59-66	folate transporter 1	Arabidopsis thaliana	10-17
16128738-1	2005	Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme regulating folate metabolism, which affects DNA methylation and synthesis.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
16128738-12	2005	Although the underlying mechanisms still remain to be clarified, epidemiological findings regarding MTHFR C677T polymorphism provide strong evidence that adequate folate status confers protection from colorectal cancer.	Folic Acid	163-169	methylenetetrahydrofolate reductase	Homo sapiens	100-105
16135938-12	2005	CONCLUSION: Maternal and fetal MTHFR C677T polymorphism may be associated with a moderately increased risk of gestational hypertension, and there is a suggestion that this association may be diminished among women receiving folate supplementation during pregnancy.	Folic Acid	224-230	methylenetetrahydrofolate reductase	Homo sapiens	31-36
16097444-2	2005	Single nucleotide polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene can modulate the effect of folate.	Folic Acid	58-64	methylenetetrahydrofolate reductase	Homo sapiens	76-81
16115544-4	2005	We found that the low-folate diet significantly decreases the AdoMet/AdoHcy ratio in brain tissue and results in an almost threefold extension of mean life span in the protein repair-deficient mice.	Folic Acid	22-28	methionine adenosyltransferase I, alpha	Mus musculus	62-68
15964170-1	2005	Folate, methionine, betaine, choline, zinc and Vitamins B(12), B(6) and B(2) are involved in one-carbon metabolism, which includes S-adenosylmethionine (SAM) substrated methylation.	Folic Acid	0-6	immunoglobulin kappa variable 5-2	Homo sapiens	72-76
15705656-5	2005	Liver CYP2E1 and the endoplasmic reticulum stress signals glucose-regulated protein 78 (GRP78), caspase 12, and sterol regulatory element binding protein-1c (SREBP-1c) were each activated in pigs fed folate-deficient or ethanol diets singly or in combination.	Folic Acid	200-206	sterol regulatory element binding transcription factor 1	Sus scrofa	112-156
15705656-5	2005	Liver CYP2E1 and the endoplasmic reticulum stress signals glucose-regulated protein 78 (GRP78), caspase 12, and sterol regulatory element binding protein-1c (SREBP-1c) were each activated in pigs fed folate-deficient or ethanol diets singly or in combination.	Folic Acid	200-206	sterol regulatory element binding transcription factor 1	Sus scrofa	158-166
15959874-11	2005	Maternal folate supplementation partially rescued the NTD phenotype, whereas GM1 significantly restored folate concentrations and afforded almost complete protection against FB1-induced NTDs.	Folic Acid	104-110	coenzyme Q10A	Mus musculus	77-80
15790587-2	2005	Therefore, the functional polymorphisms in genes encoding folate metabolizing enzymes, MTHFR C677T and MTR A2756G, might be suspected of impacting on esophageal cancer risk.	Folic Acid	58-64	methylenetetrahydrofolate reductase	Homo sapiens	87-92
15790587-5	2005	Folate consumption and MTHFR 677TT were associated with a non-significant tendency for decreased risk while the MTR genotypes did not show any links in themselves; further, when analysis was limited to heavy drinkers, the MTHFR TT genotype significantly decreased esophageal cancer risk [odds ratio (OR) = 0.27, 95% confidence interval (CI), 0.09-0.76].	Folic Acid	0-6	methylenetetrahydrofolate reductase	Homo sapiens	222-227
16335688-6	2005	Several experimental study have shown that hypothyroidism affects folate metabolism and the enzymes involved in the remetylation pathway of homocysteine (particularly 5,10-methylenotetrahydrofolate reductase - MTHFR).	Folic Acid	66-72	methylenetetrahydrofolate reductase	Homo sapiens	210-215
15916056-4	2005	When the data were grouped according to homocysteine concentration and MTHFR gene polymorphism, there were significantly higher homocysteine concentrations in the overweight/obese subjects than the control subjects in wild type gene polymorphism (CC) in the hyperhomocysteine group (homocysteine &gt;10.0 mmol/l) (p &lt; 0.05), but in genotype polymorphism (CC, CT, TT) there were lower folic acid and vitamin B12 concentrations in the overweight/obese subjects than in the control subjects.	Folic Acid	387-397	methylenetetrahydrofolate reductase	Homo sapiens	71-76
15952646-1	2005	OBJECTIVE: Methylene tetrahydrofolate reductase (MTHFR) is the key enzyme in folate metabolism.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	49-54
15579899-11	2005	Multidrug resistance-associated proteins 1 and 3 were, likewise, elevated in intestine from folate-deficient mice (53- and 168-fold, respectively); however, there were no significant changes in kidney.	Folic Acid	92-98	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Mus musculus	0-48
15579899-12	2005	Our results document the existence of four unique noncoding exons and promoters for mRFC and demonstrate a facile induction of mRNAs for mRFC and multidrug resistance-associated proteins 1 and 3 in intestine in response to changes in dietary folate intake.	Folic Acid	242-248	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	Mus musculus	146-194
15705887-4	2005	In contrast, subtle changes in folate homeostasis resulted from targeted deletion of RFC1 (RFC1(+/-)).	Folic Acid	31-37	solute carrier family 19 (folate transporter), member 1	Mus musculus	85-89
15705887-4	2005	In contrast, subtle changes in folate homeostasis resulted from targeted deletion of RFC1 (RFC1(+/-)).	Folic Acid	31-37	solute carrier family 19 (folate transporter), member 1	Mus musculus	91-95
15705887-13	2005	In conclusion, Folbp1 and RFC1 genetically modified mice exhibit distinct changes in colonocyte phenotype and therefore have utility as models to examine the role of folate homeostasis in colon cancer development.	Folic Acid	166-172	solute carrier family 19 (folate transporter), member 1	Mus musculus	26-30
15720206-7	2005	Remarkably, a gene-nutrient interaction between folate status and a polymorphism in methylenetetrahydrofolate reductase gene has been reported to modulate genomic DNA methylation.	Folic Acid	48-54	methylenetetrahydrofolate reductase	Homo sapiens	84-119
16122883-2	2005	The putative tumor suppressor gene deleted in colorectal carcinoma (DCC) is one of several genes the expression of which seems to be affected by the folate concentration at the tissue level.	Folic Acid	149-155	DCC netrin 1 receptor	Homo sapiens	35-66
16122883-2	2005	The putative tumor suppressor gene deleted in colorectal carcinoma (DCC) is one of several genes the expression of which seems to be affected by the folate concentration at the tissue level.	Folic Acid	149-155	DCC netrin 1 receptor	Homo sapiens	68-71
16122883-4	2005	The purpose of this study was to analyze if the folate level and the gene expression levels of reduced folate carrier (RFC-1) and folylpolyglutamate synthase (FPGS) had impact on the expression of DCC splice variants.	Folic Acid	48-54	DCC netrin 1 receptor	Homo sapiens	197-200
16122883-4	2005	The purpose of this study was to analyze if the folate level and the gene expression levels of reduced folate carrier (RFC-1) and folylpolyglutamate synthase (FPGS) had impact on the expression of DCC splice variants.	Folic Acid	103-109	replication factor C subunit 1	Homo sapiens	119-124
16122883-4	2005	The purpose of this study was to analyze if the folate level and the gene expression levels of reduced folate carrier (RFC-1) and folylpolyglutamate synthase (FPGS) had impact on the expression of DCC splice variants.	Folic Acid	103-109	DCC netrin 1 receptor	Homo sapiens	197-200
16122883-9	2005	CONCLUSIONS: In conclusion, the present study points to a potential influence of folates in regulating DCC expression at multiple levels involving post-transcriptional pathways.	Folic Acid	81-88	DCC netrin 1 receptor	Homo sapiens	103-106
15895286-1	2005	This study aimed at assessing the effect of folic acid supplementation quantitatively in each MTHFR C677T genotype and considered the efficiency of tailor-made prevention of atherosclerosis.	Folic Acid	44-54	methylenetetrahydrofolate reductase	Homo sapiens	94-99
16433478-6	2005	Patients homozygous and, to a lesser extent heterozygous, to the C677T thermolabile variant of methylenetetrahydrofolate reductase (MTHFR) presented a reduced catalytic activity and required a higher folic acid dose.	Folic Acid	200-210	methylenetetrahydrofolate reductase	Homo sapiens	95-130
16433478-6	2005	Patients homozygous and, to a lesser extent heterozygous, to the C677T thermolabile variant of methylenetetrahydrofolate reductase (MTHFR) presented a reduced catalytic activity and required a higher folic acid dose.	Folic Acid	200-210	methylenetetrahydrofolate reductase	Homo sapiens	132-137
15546509-9	2004	The findings add to evidence that individuals with the MTHFR 677TT genotype have a decreased risk of colorectal cancer in the absence of folate depletion, suggesting a protective role of folate by ensuring a sufficient thymidylate pool for DNA synthesis.	Folic Acid	187-193	methylenetetrahydrofolate reductase	Homo sapiens	55-60
15286469-4	2004	The multivariate-adjusted ORs comparing the highest to lowest tertile of total folate intake according to those with the MTHFR CC, CT, and TT genotypes, were, respectively, 0.65 (CI: 0.30-1.39), 0.57 (CI: 0.23-1.44), and 0.22 (CI: 0.02-3.19).	Folic Acid	79-85	methylenetetrahydrofolate reductase	Homo sapiens	121-126
15149334-6	2004	Matrilysin expression was also induced by acute folic acid nephropathy and unilateral ureteral obstruction (UUO) in the mouse, and expression increased as acute injury progressed to tubulointerstitial fibrosis.	Folic Acid	48-58	matrix metallopeptidase 7	Mus musculus	0-10
15149334-8	2004	Wnt signaling can induce matrilysin expression, and we found that the pattern of matrilysin expression during progression of renal fibrosis in the mouse after UUO or folic acid nephropathy, and in the jck model of murine polycystic kidney disease, closely paralleled that of Wnt4.	Folic Acid	166-176	matrix metallopeptidase 7	Mus musculus	81-91
15217535-7	2004	Carriers of the MTHFR 677T allele could benefit from supplementation with folic acid and vitamin B12.	Folic Acid	74-84	methylenetetrahydrofolate reductase	Homo sapiens	16-21
15110890-0	2004	Reduced breast cancer risk with increasing serum folate in a case-control study of the C677T genotype of the methylenetetrahydrofolate reductase gene.	Folic Acid	49-55	methylenetetrahydrofolate reductase	Homo sapiens	109-144
14769778-2	2004	Methylenetetrahydrofolate reductase (MTHFR) is a regulating enzyme in folate-dependant homocysteine remethylation, because it catalyses the reduction of 5,10 methylenetetrahydrofolate to 5-methyltetrahydrofolate (5-MTHF).	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
15639995-4	2004	This paper reviews folate transport carrier, Reduced Folate Carrier (RFC)"s characteristics in biological chemistry, physiological function, the folate transport mechanism, structure, function, regulation and expression of reduced folate carrier gene (RFC1), and the relationship between RFC1 with plasm or erythrocyte folate level and neural tube defects, et al.	Folic Acid	19-25	replication factor C subunit 1	Homo sapiens	288-292
15639995-4	2004	This paper reviews folate transport carrier, Reduced Folate Carrier (RFC)"s characteristics in biological chemistry, physiological function, the folate transport mechanism, structure, function, regulation and expression of reduced folate carrier gene (RFC1), and the relationship between RFC1 with plasm or erythrocyte folate level and neural tube defects, et al.	Folic Acid	53-59	replication factor C subunit 1	Homo sapiens	252-256
15639995-4	2004	This paper reviews folate transport carrier, Reduced Folate Carrier (RFC)"s characteristics in biological chemistry, physiological function, the folate transport mechanism, structure, function, regulation and expression of reduced folate carrier gene (RFC1), and the relationship between RFC1 with plasm or erythrocyte folate level and neural tube defects, et al.	Folic Acid	53-59	replication factor C subunit 1	Homo sapiens	288-292
15228210-5	2004	In the female subjects, serum folate concentrations differed among MTHFR genotypes, being lowest in the VV group.	Folic Acid	30-36	methylenetetrahydrofolate reductase	Homo sapiens	67-72
15228210-8	2004	High folate and vitamin C consumptions, appears to be beneficial to normal and heterozygous MTHFR genotype subjects for maintaining serum folate concentrations.	Folic Acid	5-11	methylenetetrahydrofolate reductase	Homo sapiens	92-97
15228210-8	2004	High folate and vitamin C consumptions, appears to be beneficial to normal and heterozygous MTHFR genotype subjects for maintaining serum folate concentrations.	Folic Acid	138-144	methylenetetrahydrofolate reductase	Homo sapiens	92-97
15228210-9	2004	Even a 400 microg daily intake of folate might be less than what is needed, especially for homozygous MTHFR subjects and smokers, to maintain an adequate serum folate concentration.	Folic Acid	34-40	methylenetetrahydrofolate reductase	Homo sapiens	102-107
15228210-9	2004	Even a 400 microg daily intake of folate might be less than what is needed, especially for homozygous MTHFR subjects and smokers, to maintain an adequate serum folate concentration.	Folic Acid	160-166	methylenetetrahydrofolate reductase	Homo sapiens	102-107
15218538-9	2004	The reactions that remove homocysteine are very sensitive to B vitamin status as both the transsulfuration enzymes contain pyridoxal phosphate, while methionine synthase contains cobalamin and receives its methyl group from the folic acid one-carbon pool.	Folic Acid	228-238	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	150-169
14676127-2	2003	EXPERIMENTAL DESIGN: Real-time PCR was used to quantify expression levels of folate-associated genes including the reduced folate carrier (RFC-1), folylpolyglutamate synthase (FPGS), gamma-glutamyl hydrolase (GGH),and thymidylate synthase (TS) in tumor tissue and adjacent mucosa of patients with primary colorectal cancer (n=102).	Folic Acid	77-83	replication factor C subunit 1	Homo sapiens	139-144
14676127-7	2003	The total reduced folate concentration correlated with the gene expression levels of RFC-1 and FPGS but not with TS or GGH.	Folic Acid	18-24	replication factor C subunit 1	Homo sapiens	85-90
14652356-0	2003	Folate status response to controlled folate intake is affected by the methylenetetrahydrofolate reductase 677C--&gt;T polymorphism in young women.	Folic Acid	0-6	methylenetetrahydrofolate reductase	Homo sapiens	70-105
14652356-0	2003	Folate status response to controlled folate intake is affected by the methylenetetrahydrofolate reductase 677C--&gt;T polymorphism in young women.	Folic Acid	37-43	methylenetetrahydrofolate reductase	Homo sapiens	70-105
14652356-1	2003	This study was designed to evaluate the effect of the methylenetetrahydrofolate reductase (MTHFR) 677C--&gt;T polymorphism on folate and homocysteine response in non-Hispanic women consuming a low folate diet followed by a diet providing the Recommended Dietary Allowance (RDA) for folate.	Folic Acid	73-79	methylenetetrahydrofolate reductase	Homo sapiens	91-96
14652356-1	2003	This study was designed to evaluate the effect of the methylenetetrahydrofolate reductase (MTHFR) 677C--&gt;T polymorphism on folate and homocysteine response in non-Hispanic women consuming a low folate diet followed by a diet providing the Recommended Dietary Allowance (RDA) for folate.	Folic Acid	126-132	methylenetetrahydrofolate reductase	Homo sapiens	54-89
14652356-1	2003	This study was designed to evaluate the effect of the methylenetetrahydrofolate reductase (MTHFR) 677C--&gt;T polymorphism on folate and homocysteine response in non-Hispanic women consuming a low folate diet followed by a diet providing the Recommended Dietary Allowance (RDA) for folate.	Folic Acid	126-132	methylenetetrahydrofolate reductase	Homo sapiens	91-96
14652356-1	2003	This study was designed to evaluate the effect of the methylenetetrahydrofolate reductase (MTHFR) 677C--&gt;T polymorphism on folate and homocysteine response in non-Hispanic women consuming a low folate diet followed by a diet providing the Recommended Dietary Allowance (RDA) for folate.	Folic Acid	126-132	methylenetetrahydrofolate reductase	Homo sapiens	54-89
14652356-1	2003	This study was designed to evaluate the effect of the methylenetetrahydrofolate reductase (MTHFR) 677C--&gt;T polymorphism on folate and homocysteine response in non-Hispanic women consuming a low folate diet followed by a diet providing the Recommended Dietary Allowance (RDA) for folate.	Folic Acid	126-132	methylenetetrahydrofolate reductase	Homo sapiens	91-96
14652356-8	2003	These data suggest that the MTHFR 677C--&gt;T polymorphism negatively affects the folate and homocysteine response in women consuming low folate diets followed by repletion with the RDA.	Folic Acid	82-88	methylenetetrahydrofolate reductase	Homo sapiens	28-33
14652356-8	2003	These data suggest that the MTHFR 677C--&gt;T polymorphism negatively affects the folate and homocysteine response in women consuming low folate diets followed by repletion with the RDA.	Folic Acid	138-144	methylenetetrahydrofolate reductase	Homo sapiens	28-33
14652356-9	2003	These results may be important when evaluating the impact of the MTHFR 677C--&gt;T polymorphism in countries in which low folate diets are chronically consumed.	Folic Acid	122-128	methylenetetrahydrofolate reductase	Homo sapiens	65-70
14597174-1	2003	The eukaryotic trifunctional enzyme, C(1)-tetrahydrofolate (THF) synthase, interconverts folic acid derivatives between various oxidation states and is critical for normal cellular function, growth, and differentiation.	Folic Acid	89-99	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Rattus norvegicus	37-73
14608109-6	2003	Cancer risk may be increased in individuals with the homozygous genotype for the MTHFR 677C--&gt;T polymorphism who have low status of methyl-related nutrients including folate.	Folic Acid	170-176	methylenetetrahydrofolate reductase	Homo sapiens	81-86
14572619-4	2003	In addition to the prevalence of the 677C--&gt;T mutation in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, we compared plasma and red blood cell (RBC) folate, vitamin B6, vitamin B12, and homocysteine (Hcy) concentrations of 35 schizophrenic patients with those of 104 unrelated controls.	Folic Acid	89-95	methylenetetrahydrofolate reductase	Homo sapiens	107-112
15004488-1	2003	The methylenetetrahydrofolate reductase (MTHFR) gene is a polymorphic gene involved in folate metabolism, DNA biosynthesis, methylation and genomic integrity in actively dividing cells.	Folic Acid	23-29	methylenetetrahydrofolate reductase	Homo sapiens	41-46
14572159-2	2003	A common 677C&gt;T polymorphism in the gene for MTHFR, leading to a thermolabile enzyme with decreased activity, has been associated with reduced plasma folate levels and elevated homocysteine levels and could be a risk factor for breast cancer.	Folic Acid	153-159	methylenetetrahydrofolate reductase	Homo sapiens	48-53
13678724-2	2003	Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme regulating the metabolism of folate and methionine, the important components of DNA synthesis and methylation.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
12949355-9	2003	These data are consistent with the current understanding of the molecular interaction of the MTHFR mutant with folate substrates and the FAD prosthetic group.	Folic Acid	111-117	methylenetetrahydrofolate reductase	Homo sapiens	93-98
12897091-2	2003	The C677T polymorphism of the MTHFR gene has been reported to be associated with elevated plasma homocysteine in patients with low folic acid intake.	Folic Acid	131-141	methylenetetrahydrofolate reductase	Homo sapiens	30-35
12832086-1	2003	The reduced folate carrier (RFC), a facilitative transporter, plays a major role in the delivery of reduced folates and antifolates into cells.	Folic Acid	108-115	solute carrier family 19 (folate transporter), member 1	Mus musculus	4-26
12832086-1	2003	The reduced folate carrier (RFC), a facilitative transporter, plays a major role in the delivery of reduced folates and antifolates into cells.	Folic Acid	108-115	solute carrier family 19 (folate transporter), member 1	Mus musculus	28-31
12832086-2	2003	Previous studies indicated that mutations of E45K in the first transmembrane domain (TMD), and K404L in the 11th TMD, produce selective and opposite alterations in binding of natural folate substrates to murine RFC.	Folic Acid	183-189	solute carrier family 19 (folate transporter), member 1	Mus musculus	211-214
12948423-4	2003	However, to serve as the active mediator, folate requires metabolism catalyzed by several enzymes including methylenetetrahydrofolate reductase (MTHFR), which plays a central role in biotransformation of folate.	Folic Acid	42-48	methylenetetrahydrofolate reductase	Homo sapiens	108-143
12948423-4	2003	However, to serve as the active mediator, folate requires metabolism catalyzed by several enzymes including methylenetetrahydrofolate reductase (MTHFR), which plays a central role in biotransformation of folate.	Folic Acid	42-48	methylenetetrahydrofolate reductase	Homo sapiens	145-150
12948423-4	2003	However, to serve as the active mediator, folate requires metabolism catalyzed by several enzymes including methylenetetrahydrofolate reductase (MTHFR), which plays a central role in biotransformation of folate.	Folic Acid	127-133	methylenetetrahydrofolate reductase	Homo sapiens	145-150
12801615-0	2003	Methylenetetrahydrofolate reductase (MTHFR) 677C&gt;T and methionine synthase reductase (MTRR) 66A&gt;G polymorphisms: association with serum homocysteine and angiographic coronary artery disease in the era of flour products fortified with folic acid.	Folic Acid	240-250	methylenetetrahydrofolate reductase	Homo sapiens	0-35
12753319-1	2003	BACKGROUND: The effect of the glutamate carboxypeptidase II GCP2 1561C&gt;T and the reduced folate carrier 1 RFC1 80G&gt;A polymorphisms on folate and total homocysteine (tHcy) plasma levels of kidney transplant patients are unknown.	Folic Acid	92-98	replication factor C subunit 1	Homo sapiens	109-113
12753319-1	2003	BACKGROUND: The effect of the glutamate carboxypeptidase II GCP2 1561C&gt;T and the reduced folate carrier 1 RFC1 80G&gt;A polymorphisms on folate and total homocysteine (tHcy) plasma levels of kidney transplant patients are unknown.	Folic Acid	140-146	replication factor C subunit 1	Homo sapiens	109-113
12854905-0	2003	Activity of a novel anti-folate (PDX, 10-propargyl 10-deazaaminopterin) against human lymphoma is superior to methotrexate and correlates with tumor RFC-1 gene expression.	Folic Acid	25-31	replication factor C subunit 1	Homo sapiens	149-154
12854905-10	2003	RT-PCR analysis for the expression of genes involved in folate metabolism demonstrated that increased sensitivity to PDX correlated with higher RFC-1 gene expression with no difference in FPGS or FPGH levels, suggesting that measurement of tumor RFC-1 gene expression level may be a predictor of response to PDX.	Folic Acid	56-62	replication factor C subunit 1	Homo sapiens	246-251
12707953-2	2003	MTHFR plays a central role in the metabolism of folate.	Folic Acid	48-54	methylenetetrahydrofolate reductase	Homo sapiens	0-5
12730409-1	2003	A common genetic variant in the methylenetetrahydrofolate reductase (MTHFR) gene involving a cytosine to thymidine (C--&gt;T) transition at nucleotide 677 is associated with reduced enzyme activity, altered folate status and potentially higher folate requirements.	Folic Acid	51-57	methylenetetrahydrofolate reductase	Homo sapiens	69-74
12730409-1	2003	A common genetic variant in the methylenetetrahydrofolate reductase (MTHFR) gene involving a cytosine to thymidine (C--&gt;T) transition at nucleotide 677 is associated with reduced enzyme activity, altered folate status and potentially higher folate requirements.	Folic Acid	207-213	methylenetetrahydrofolate reductase	Homo sapiens	32-67
12730409-1	2003	A common genetic variant in the methylenetetrahydrofolate reductase (MTHFR) gene involving a cytosine to thymidine (C--&gt;T) transition at nucleotide 677 is associated with reduced enzyme activity, altered folate status and potentially higher folate requirements.	Folic Acid	207-213	methylenetetrahydrofolate reductase	Homo sapiens	69-74
12730409-2	2003	The objectives of this study were to investigate the effect of the MTHFR 677 T allele on folate status variables in Mexican women (n = 43; 18-45 y) and to assess the adequacy of the 1998 folate U.S.	Folic Acid	89-95	methylenetetrahydrofolate reductase	Homo sapiens	67-72
12730409-10	2003	Collectively, these data demonstrate that the MTHFR C--&gt;T variant modulates folate status response to controlled folate intakes and support the adequacy of the 1998 folate U.S. RDA for all three MTHFR C677T genotypes.	Folic Acid	79-85	methylenetetrahydrofolate reductase	Homo sapiens	46-51
12730409-10	2003	Collectively, these data demonstrate that the MTHFR C--&gt;T variant modulates folate status response to controlled folate intakes and support the adequacy of the 1998 folate U.S. RDA for all three MTHFR C677T genotypes.	Folic Acid	116-122	methylenetetrahydrofolate reductase	Homo sapiens	46-51
12730410-1	2003	The 677 C--&gt;T polymorphism in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene interacts with folate status in determining elevated total plasma levels of homocysteine, a risk factor for coronary atherosclerotic disease (CAD).	Folic Acid	61-67	methylenetetrahydrofolate reductase	Homo sapiens	79-84
12730410-4	2003	The MTHFR 677 C--&gt;T genotype-specific threshold values of plasma folate corresponded to the 40th, 30th and 10th percentile in the TT, CT and CC genotype, respectively.	Folic Acid	68-74	methylenetetrahydrofolate reductase	Homo sapiens	4-9
12730410-7	2003	A gene-nutrient interaction that defines a higher risk for CAD is determined by folate levels below specific thresholds, which differ depending on the MTHFR 677 C--&gt;T genotype.	Folic Acid	80-86	methylenetetrahydrofolate reductase	Homo sapiens	151-156
12672676-4	2003	Two MTHFR polymorphisms, C677T and A1298C, have been associated with reduced enzyme activity and C677T with altered distribution of intracellular folate metabolites.	Folic Acid	146-152	methylenetetrahydrofolate reductase	Homo sapiens	4-9
12672677-2	2003	Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene reduce availability of 5-methyltetrahydrofolate, the predominant circulating form of folate.	Folic Acid	40-46	methylenetetrahydrofolate reductase	Homo sapiens	58-63
12649184-2	2003	A common Ala(222)/Val variant in the methylenetetrahydrofolate reductase (MTHFR) gene leads to a disturbed folate metabolism and is associated with decreased genomic DNA methylation.	Folic Acid	56-62	methylenetetrahydrofolate reductase	Homo sapiens	74-79
12751548-1	2003	Nitrous oxide interacts with vitamin B12 resulting in selective inhibition of methionine synthase, a key enzyme in methionine and folate metabolism.	Folic Acid	130-136	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	78-97
12602921-1	2003	OBJECTIVE: Methylenetetrahydrofolate reductase (MTHFR), a polymorphic enzyme involved in folate metabolism, plays a role in DNA biosynthesis, methylation, and repair in actively dividing cells.	Folic Acid	30-36	methylenetetrahydrofolate reductase	Homo sapiens	48-53
12602921-10	2003	These findings should be explored with a larger sample size in order to analyze gene-environment interactions between MTHFR and folate.	Folic Acid	128-134	methylenetetrahydrofolate reductase	Homo sapiens	118-123
12522558-1	2003	Elevated levels of plasma homocysteine (Hcy), a risk factor for coronary artery disease (CAD), can result from genetic errors, e.g., the methylenetetrahydrofolate reductase (MTHFR) polymorphism, or nutritional deficiencies, e.g., in vitamin B12 and folate.	Folic Acid	156-162	methylenetetrahydrofolate reductase	Homo sapiens	174-179
12690011-2	2003	Methylenetetrahydrofolate reductase (MTHFR) is a key regulatory enzyme in folate metabolism.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
12690011-10	2003	CONCLUSIONS: The findings suggest an interaction between folate and the MTHFR genotype on colorectal adenomas.	Folic Acid	57-63	methylenetetrahydrofolate reductase	Homo sapiens	72-77
12499324-1	2003	BACKGROUND: Homozygotes for the thermolabile mutation (TT genotype) of the methylenetetrahydrofolate reductase (MTHFR; EC 1.5.1.20) enzyme have elevated plasma concentrations of the cardiovascular disease risk factor homocysteine, particularly if folate depleted.	Folic Acid	94-100	methylenetetrahydrofolate reductase	Homo sapiens	112-117
12893078-0	2003	Folic acid mediated attenuation of loss of heterozygosity of DCC tumor suppressor gene in the colonic mucosa of patients with colorectal adenomas.	Folic Acid	0-10	DCC netrin 1 receptor	Homo sapiens	61-64
12893078-3	2003	The primary objective of the current investigation was to determine whether folic acid would prevent LOH of the three tumor suppressor genes, deleted in colorectal cancer (DCC), adenomatous polyposis coli (APC) and p53 in macroscopically normal appearing rectal mucosa of patients with adenomatous polyps.	Folic Acid	76-86	DCC netrin 1 receptor	Homo sapiens	142-170
12893078-3	2003	The primary objective of the current investigation was to determine whether folic acid would prevent LOH of the three tumor suppressor genes, deleted in colorectal cancer (DCC), adenomatous polyposis coli (APC) and p53 in macroscopically normal appearing rectal mucosa of patients with adenomatous polyps.	Folic Acid	76-86	DCC netrin 1 receptor	Homo sapiens	172-175
12893078-8	2003	Folate supplementation prevented LOH of DCC gene in five out of five (100%) patients who demonstrated baseline heterozygosity, whereas two out of four (50%) placebo-treated patients with baseline heterozygosity demonstrated allelic loss.	Folic Acid	0-6	DCC netrin 1 receptor	Homo sapiens	40-43
12893078-13	2003	Our results indicate that folic acid prevents an increase in proliferation and arrests LOH of DCC gene and also stabilizes its protein in normal appearing rectal mucosa of patients with colorectal adenomas.	Folic Acid	26-36	DCC netrin 1 receptor	Homo sapiens	94-97
14564626-7	2003	Methylene-tetrahydrofolate reductase (MTHFR) and methionine synthase (MS) are the enzymes involved in folate metabolism and are thought to influence DNA methylation.	Folic Acid	20-26	methylenetetrahydrofolate reductase	Homo sapiens	38-43
14564626-7	2003	Methylene-tetrahydrofolate reductase (MTHFR) and methionine synthase (MS) are the enzymes involved in folate metabolism and are thought to influence DNA methylation.	Folic Acid	20-26	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	49-68
14564626-8	2003	MTHFR is highly polymorphic, and the variant genotypes result in decreased MTHFR enzyme activity and lower plasma folate level.	Folic Acid	114-120	methylenetetrahydrofolate reductase	Homo sapiens	0-5
12560871-1	2003	Common single nucleotide polymorphisms (SNPs; 677C&gt;T and 1298A&gt;C) in the methylenetetrahydrofolate reductase gene ( MTHFR) decrease the activity of the enzyme, leading to hyperhomocysteinemia, particularly in folate-deficient states.	Folic Acid	98-104	methylenetetrahydrofolate reductase	Homo sapiens	122-127
12359353-0	2002	De novo methylation of the p16INK4A gene in early preneoplastic liver and tumors induced by folate/methyl deficiency in rats.	Folic Acid	92-98	cyclin-dependent kinase inhibitor 2A	Rattus norvegicus	27-35
12359353-2	2002	In the present study, the folate/methyl-deficient model of multistage hepatocarcinogenesis was used to evaluate progressive in vivo changes in p16 promoter methylation in both preneoplastic and tumor tissues.	Folic Acid	26-32	cyclin-dependent kinase inhibitor 2A	Rattus norvegicus	143-146
12228234-0	2002	The human reduced folate carrier gene is regulated by the AP2 and sp1 transcription factor families and a functional 61-base pair polymorphism.	Folic Acid	18-24	transcription factor AP-2 alpha	Homo sapiens	58-61
12433726-1	2002	Methylenetetrahydrofolate reductase (MTHFR) plays a centralrole in converting folate to methyl donor for DNA methylation, an epigenetic modification known to be dysregulated in carcinogenesis.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
12387655-2	2002	The MTHFR 677C--&gt;T polymorphism is a genetic alteration in an enzyme involved in folate metabolism that causes elevated homocysteine concentrations, but its relevance to risk of CHD is uncertain.	Folic Acid	84-90	methylenetetrahydrofolate reductase	Homo sapiens	4-9
12387655-12	2002	CONCLUSIONS: Individuals with the MTHFR 677 TT genotype had a significantly higher risk of CHD, particularly in the setting of low folate status.	Folic Acid	131-137	methylenetetrahydrofolate reductase	Homo sapiens	34-39
12215845-4	2002	These associations were independent of the well-established methylenetetrahydrofolate reductase ( MTHFR) C677T genotype effects on plasma folate and homocysteine levels.	Folic Acid	79-85	methylenetetrahydrofolate reductase	Homo sapiens	98-103
12215845-5	2002	Our results suggest that TYMS and MTHFR compete for limiting supplies of folate required for the remethylation of homocysteine.	Folic Acid	73-79	methylenetetrahydrofolate reductase	Homo sapiens	34-39
12145019-1	2002	BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR; EC 1.7.99.5) supplies the folate needed for the metabolism of homocysteine.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	49-54
12180000-14	2002	However, in folic acid resistant group, who were in 30% homozygotes for C667T of MTHFR (suggesting that homocysteine-methionine remethylation cycle is disturbed), instead of the administration of folic acid, methylene tetrahydrofolate supplementation might be considered.	Folic Acid	12-22	methylenetetrahydrofolate reductase	Homo sapiens	81-86
12133463-1	2002	OBJECTIVE: To explore the relationship between genetic polymorphisms in methylenetetrahydrofolate reductase (MTHFR), a central enzyme in folate metabolism that affects DNA methylation and synthesis, and the risk of adenocarcinoma of the gastric cardia (AGC).	Folic Acid	91-97	methylenetetrahydrofolate reductase	Homo sapiens	109-114
11979347-13	2002	These results indicate that MTHFR genotype influences the correlation of Hcy level with vitamin B12 and folate levels in HD patients.	Folic Acid	104-110	methylenetetrahydrofolate reductase	Homo sapiens	28-33
11979347-15	2002	The efficacy of vitamin B12 and folate supplementation on plasma Hcy levels may depend on MTHFR genotype.	Folic Acid	32-38	methylenetetrahydrofolate reductase	Homo sapiens	90-95
12042168-1	2002	Relationship with plasmatic folic acid levels and 677C T polymorphism of 5,10-methylenetetrahydrofolate reductase].	Folic Acid	28-38	methylenetetrahydrofolate reductase	Homo sapiens	73-113
12186157-3	2002	Our study was aimed at finding the relationship between HCA, folate, vitamins B12 levels, and mutations in the 5,10-methylenetetrahydrofolate reductase (MTHFR) and cystathionine beta-synthase (CBS) genes.	Folic Acid	61-67	methylenetetrahydrofolate reductase	Homo sapiens	111-151
12186157-3	2002	Our study was aimed at finding the relationship between HCA, folate, vitamins B12 levels, and mutations in the 5,10-methylenetetrahydrofolate reductase (MTHFR) and cystathionine beta-synthase (CBS) genes.	Folic Acid	61-67	methylenetetrahydrofolate reductase	Homo sapiens	153-158
11929966-9	2002	These results indicate that the MTHFR C677T polymorphism influences DNA methylation status through an interaction with folate status.	Folic Acid	119-125	methylenetetrahydrofolate reductase	Homo sapiens	32-37
11950713-6	2002	(2) During folic acid treatment, normalization of homocysteine levels was accompanied by a marked reduction in oxidized low density lipoprotein-stimulated release of CXC chemokines (ie, GROalpha, ENA-78, and interleukin-8) and CC chemokines (ie, monocyte chemoattractant peptide-1 and RANTES) in peripheral blood mononuclear cells from these individuals.	Folic Acid	11-21	C-X-C motif chemokine ligand 1	Homo sapiens	186-194
11950713-6	2002	(2) During folic acid treatment, normalization of homocysteine levels was accompanied by a marked reduction in oxidized low density lipoprotein-stimulated release of CXC chemokines (ie, GROalpha, ENA-78, and interleukin-8) and CC chemokines (ie, monocyte chemoattractant peptide-1 and RANTES) in peripheral blood mononuclear cells from these individuals.	Folic Acid	11-21	C-X-C motif chemokine ligand 5	Homo sapiens	196-202
11950713-6	2002	(2) During folic acid treatment, normalization of homocysteine levels was accompanied by a marked reduction in oxidized low density lipoprotein-stimulated release of CXC chemokines (ie, GROalpha, ENA-78, and interleukin-8) and CC chemokines (ie, monocyte chemoattractant peptide-1 and RANTES) in peripheral blood mononuclear cells from these individuals.	Folic Acid	11-21	C-C motif chemokine ligand 5	Homo sapiens	285-291
11880124-1	2002	BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) deficiency leads to impairment in folate metabolism and is implicated as a risk factor for neural tube defects (NTDs).	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	49-54
11889073-1	2002	BACKGROUND: The enzyme methylenetetrahydrofolate reductase (MTHFR) catalyses the formation of folate intermediates that are vital to methylation reactions.	Folic Acid	42-48	methylenetetrahydrofolate reductase	Homo sapiens	60-65
11889073-12	2002	CONCLUSIONS: The TT genotype of MTHFR is associated with an increased risk of CRC in older populations, possibly due to age related disturbances in folate metabolism.	Folic Acid	148-154	methylenetetrahydrofolate reductase	Homo sapiens	32-37
11872199-1	2002	OBJECTIVE: To evaluate the relationships among the methylenetetrahydrofolate reductase (MTHFR) polymorphism, plasma folate, total homocysteine (Hcy) levels, lipids, and the reduction of Hcy levels resulting from hormone replacement therapy (HRT).	Folic Acid	70-76	methylenetetrahydrofolate reductase	Homo sapiens	88-93
11857369-7	2002	Folate intake was inversely associated with colorectal cancer risk (IRR = 0.6, 95% CI = 0.4-1.1, p for trend = 0.25).	Folic Acid	0-6	insulin receptor related receptor	Homo sapiens	68-71
11863127-3	2002	A homozygous C677T MTHFR was found with low folate status.	Folic Acid	44-50	methylenetetrahydrofolate reductase	Homo sapiens	19-24
11863127-8	2002	We propose mild or moderate hyperhomocysteinemia triggered by low folate status in patients with homozygous C677T MTHFR as a cause of renal arterial thrombosis.	Folic Acid	66-72	methylenetetrahydrofolate reductase	Homo sapiens	114-119
11805170-2	2002	The expression of both HGF and its c-met receptor genes is rapidly upregulated after acute renal injury induced by folic acid.	Folic Acid	115-125	hepatocyte growth factor	Mus musculus	23-26
11805170-5	2002	Simultaneous injection of HGF plasmid DNA significantly ameliorated renal dysfunctions and accelerated recovery from the acute injury induced by folic acid.	Folic Acid	145-155	hepatocyte growth factor	Mus musculus	26-29
12001978-10	2002	Homozygotes for variant MTHFR had higher homocysteine concentrations at low plasma folate (P &lt; 0.01).	Folic Acid	83-89	methylenetetrahydrofolate reductase	Homo sapiens	24-29
11807890-1	2002	Polymorphisms in genes encoding the folate metabolizing enzymes methylenetetrahydrofolate reductase (MTHFR C677T) and methionine synthase reductase (MTRR A66G) have been linked to the etiology of Down syndrome.	Folic Acid	36-42	methylenetetrahydrofolate reductase	Homo sapiens	64-99
11807890-1	2002	Polymorphisms in genes encoding the folate metabolizing enzymes methylenetetrahydrofolate reductase (MTHFR C677T) and methionine synthase reductase (MTRR A66G) have been linked to the etiology of Down syndrome.	Folic Acid	36-42	methylenetetrahydrofolate reductase	Homo sapiens	101-106
12111380-3	2002	Furthermore, several studies have suggested that a defective methionine synthase ( MS) enzyme could be a critical defect in folate-related NTDs.	Folic Acid	124-130	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	61-80
12111380-3	2002	Furthermore, several studies have suggested that a defective methionine synthase ( MS) enzyme could be a critical defect in folate-related NTDs.	Folic Acid	124-130	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	83-85
11813127-3	2001	The C677 T variant of the MTHFR gene coding for a thermolabile enzyme has been described as the first genetic risk factor that accounts for a group of NTDs characterized by low maternal folate status and high homocysteine concentrations.	Folic Acid	186-192	methylenetetrahydrofolate reductase	Homo sapiens	26-31
11744407-7	2001	When the study population was divided into 2 groups accordingly to serum folate levels (above/below the median value of 6.1 ng/ml), MTHFR genotype remained a significant predictor of homocysteine only in patients with low serum folate (p = 0.048).	Folic Acid	228-234	methylenetetrahydrofolate reductase	Homo sapiens	132-137
11731153-5	2001	The folic acid synthesis pathway in the folate utilising isolates was restored via transformation with FOL1 or FOL3 expression plasmids and transformants were tested for resistance to sulfamethoxazole (SMX).	Folic Acid	4-14	dihydrofolate synthase	Saccharomyces cerevisiae S288C	111-115
11731153-5	2001	The folic acid synthesis pathway in the folate utilising isolates was restored via transformation with FOL1 or FOL3 expression plasmids and transformants were tested for resistance to sulfamethoxazole (SMX).	Folic Acid	40-46	dihydrofolate synthase	Saccharomyces cerevisiae S288C	111-115
11600611-2	2001	Functional polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene result in intracellular redistribution of folate derivatives, which may affect raltitrexed-associated cytotoxicity.	Folic Acid	51-57	methylenetetrahydrofolate reductase	Homo sapiens	69-74
11584084-6	2001	Compared with the low folate diet, the high folate diet increased the serum folate concentration by 85% (P &lt; 0.001), 77% (P &lt; 0.001) and 55% (P &lt; 0.05) in the subjects with the genotypes C/C (n = 19), C/T (n = 13) and T/T (n = 5), respectively, of the MTHFR gene.	Folic Acid	44-50	methylenetetrahydrofolate reductase	Homo sapiens	261-266
11584084-6	2001	Compared with the low folate diet, the high folate diet increased the serum folate concentration by 85% (P &lt; 0.001), 77% (P &lt; 0.001) and 55% (P &lt; 0.05) in the subjects with the genotypes C/C (n = 19), C/T (n = 13) and T/T (n = 5), respectively, of the MTHFR gene.	Folic Acid	44-50	methylenetetrahydrofolate reductase	Homo sapiens	261-266
11584084-8	2001	The subjects carrying the G2756 allele of the MS gene (n = 15) had a more extensive reduction (P &lt; 0.05) of plasma tHcy during the high folate diet period than the subjects with the genotype A/A (n = 22).	Folic Acid	139-145	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	46-48
11494235-2	2001	The 5,10-methylenetetrahydrofolate reductase (MTHFR) involved in folate metabolism has 2 variants, C677T and A1298C, that result in decreased MTHFR activity and lower plasma folate levels.	Folic Acid	28-34	methylenetetrahydrofolate reductase	Homo sapiens	46-51
11494235-2	2001	The 5,10-methylenetetrahydrofolate reductase (MTHFR) involved in folate metabolism has 2 variants, C677T and A1298C, that result in decreased MTHFR activity and lower plasma folate levels.	Folic Acid	28-34	methylenetetrahydrofolate reductase	Homo sapiens	142-147
11494235-2	2001	The 5,10-methylenetetrahydrofolate reductase (MTHFR) involved in folate metabolism has 2 variants, C677T and A1298C, that result in decreased MTHFR activity and lower plasma folate levels.	Folic Acid	65-71	methylenetetrahydrofolate reductase	Homo sapiens	4-44
11494235-2	2001	The 5,10-methylenetetrahydrofolate reductase (MTHFR) involved in folate metabolism has 2 variants, C677T and A1298C, that result in decreased MTHFR activity and lower plasma folate levels.	Folic Acid	65-71	methylenetetrahydrofolate reductase	Homo sapiens	46-51
11494235-2	2001	The 5,10-methylenetetrahydrofolate reductase (MTHFR) involved in folate metabolism has 2 variants, C677T and A1298C, that result in decreased MTHFR activity and lower plasma folate levels.	Folic Acid	65-71	methylenetetrahydrofolate reductase	Homo sapiens	142-147
11759174-7	2001	The effect of folate seems to be modulated by alcohol, methionine, and MTHFR polymorphisms.	Folic Acid	14-20	methylenetetrahydrofolate reductase	Homo sapiens	71-76
11556805-1	2001	NEUT2 mice are deficient in cytosolic 10-formyltetrahydrofolate dehydrogenase (FDH; EC 1.5.1.6) which catalyzes the oxidation of excess folate-linked one-carbon units in the form of 10-formyltetrahydrofolate to CO(2) and tetrahydrofolate (Champion et al., Proc.	Folic Acid	57-63	aldehyde dehydrogenase 1 family, member L1	Mus musculus	0-5
11556805-1	2001	NEUT2 mice are deficient in cytosolic 10-formyltetrahydrofolate dehydrogenase (FDH; EC 1.5.1.6) which catalyzes the oxidation of excess folate-linked one-carbon units in the form of 10-formyltetrahydrofolate to CO(2) and tetrahydrofolate (Champion et al., Proc.	Folic Acid	57-63	aldehyde dehydrogenase 1 family, member L1	Mus musculus	79-82
11556805-6	2001	The absence of FDH should impair the oxidation of formate via the folate-dependent pathway and as a consequence render homozygous NEUT2 mice more susceptible to methanol toxicity.	Folic Acid	66-72	aldehyde dehydrogenase 1 family, member L1	Mus musculus	15-18
11556805-6	2001	The absence of FDH should impair the oxidation of formate via the folate-dependent pathway and as a consequence render homozygous NEUT2 mice more susceptible to methanol toxicity.	Folic Acid	66-72	aldehyde dehydrogenase 1 family, member L1	Mus musculus	130-135
11532093-3	2001	Our present study examined the changes in PTHrP and the PTH/PTHrP receptor (type 1) in folic acid-induced acute renal failure in rats.	Folic Acid	87-97	parathyroid hormone-like hormone	Rattus norvegicus	60-65
11371572-2	2001	Cobalamin (vitamin B(12)) is structurally similar to heme and is a cofactor for methionine synthase, a key enzyme in folate metabolism.	Folic Acid	117-123	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	80-99
11371572-6	2001	The inhibition of methionine synthase activity disrupted carbon flow through the folate pathway as measured by decreased incorporation of [(14)C]formate into methionine, serine, and purine nucleotides.	Folic Acid	81-87	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	18-37
11481906-2	2001	Hyperhomocysteinemia may be induced by failure or decreased enzyme activity of the cystathionine-beta-synthase and methylenetetrahydrofolate reductase due to genetic mutation or deficiency of folic acid, vitamin B12 and vitamin B6.	Folic Acid	192-202	methylenetetrahydrofolate reductase	Homo sapiens	115-150
11427193-1	2001	The reduced folate carrier (RFC1) is a major route for the transport of folates in mammalian cells.	Folic Acid	12-18	replication factor C subunit 1	Homo sapiens	28-32
11427193-1	2001	The reduced folate carrier (RFC1) is a major route for the transport of folates in mammalian cells.	Folic Acid	72-79	replication factor C subunit 1	Homo sapiens	28-32
11509098-2	2001	Increasing evidence suggests that the beneficial effect of folate may be related to improved function of methionine synthase, a vitamin B12-dependent enzyme that converts homocysteine to methionine.	Folic Acid	59-65	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	105-124
11306683-1	2001	The reduced folate carrier (RFC1) plays a major role in the delivery of folates into mammalian cells.	Folic Acid	12-18	replication factor C subunit 1	Homo sapiens	28-32
11306683-1	2001	The reduced folate carrier (RFC1) plays a major role in the delivery of folates into mammalian cells.	Folic Acid	72-79	replication factor C subunit 1	Homo sapiens	28-32
11340354-9	2001	TGF-alpha mRNA increased from 1.0 +/- 0.09 (relative densitometry units) in control animals to 2.9 +/- 0.13 in folic acid treated rats at 24 h (n = 4, p &lt; 0.01), and immunohistochemical staining for TGF-alpha increased in injured kidneys at distal nephron sites.	Folic Acid	111-121	transforming growth factor alpha	Rattus norvegicus	0-9
11273876-5	2001	A high baseline tHcy plasma concentration (P: = 0.00001), methylenetetrahydrofolate reductase (MTHFR) 677TT/1298AA genotype (P: = 0.03540), and low red blood cell folate concentrations (P: = 0.02285) were associated with a better relative response to treatment.	Folic Acid	77-83	methylenetetrahydrofolate reductase	Homo sapiens	95-100
11303694-2	2001	A common mutation (nucleotid 677C-T) in the gene coding for methylenetetrahydrofolate reductase (MTHFR) has been reported to reduce the enzymatic activity of MTHFR and is associated with elevated plasma levels of homocysteine, especially in subjects with low folate intake.	Folic Acid	79-85	methylenetetrahydrofolate reductase	Homo sapiens	97-102
11303694-2	2001	A common mutation (nucleotid 677C-T) in the gene coding for methylenetetrahydrofolate reductase (MTHFR) has been reported to reduce the enzymatic activity of MTHFR and is associated with elevated plasma levels of homocysteine, especially in subjects with low folate intake.	Folic Acid	79-85	methylenetetrahydrofolate reductase	Homo sapiens	158-163
11508713-6	2001	The enzyme kinetics of DHFR for PteGlu was examined at the physiological condition (pH 7.4 and 3 7 degrees C).	Folic Acid	32-38	dihydrofolate reductase	Sus scrofa	23-27
11508713-10	2001	The comparison of the ratio of Vmax to Km between pig and rat enzymes suggests that PteGlu is a much less efficient substrate for pig liver DHFR.	Folic Acid	84-90	dihydrofolate reductase	Sus scrofa	140-144
11508713-11	2001	In short, these results from in vivo and in vitro experiments suggest that the role of DHFR for PteGlu in pigs is physiologically much less important than that in rats.	Folic Acid	96-102	dihydrofolate reductase	Sus scrofa	87-91
2566606-4	1989	In this study, we demonstrate markedly elevated expression of the protooncogenes c-fos, c-myc, c-Ki-ras, and c-Ha-ras following acute renal injury induced by a single large parenteral dose of folic acid.	Folic Acid	192-202	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	81-86
2566606-4	1989	In this study, we demonstrate markedly elevated expression of the protooncogenes c-fos, c-myc, c-Ki-ras, and c-Ha-ras following acute renal injury induced by a single large parenteral dose of folic acid.	Folic Acid	192-202	KRAS proto-oncogene, GTPase	Homo sapiens	95-103
2468308-1	1989	C1-tetrahydrofolate synthase (C1-THF synthase), a eukaryotic trifunctional enzyme, catalyzes three sequential folate-mediated one-carbon interconversions.	Folic Acid	13-19	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Rattus norvegicus	30-45
2909524-1	1989	5,10-Dideazatetrahydrofolate (DDATHF) is a new antimetabolite designed as an inhibitor of folate metabolism at sites other than dihydrofolate reductase.	Folic Acid	22-28	dihydrofolate reductase	Mus musculus	128-151
3143307-8	1988	Thus it is possible that the effect of thiouracil in increasing folate function consists both in the effect of thiouracil in decreasing levels of methylenetetrahydrofolate reductase, and also in its action in increasing S-adenosylmethionine which exerts a feedback inhibition of this enzyme.	Folic Acid	64-70	methylenetetrahydrofolate reductase	Homo sapiens	146-181
3049954-5	1988	In the presence of a folate cofactor a covalent ternary complex is formed, the stability of which is the main determinant of the action of 5FU.	Folic Acid	21-27	tubulin folding cofactor A	Homo sapiens	28-38
3370638-8	1988	Depletion of the thymidylate synthase substrate, methylenetetrahydrofolate, could not account for diminished growth or thymidylate synthesis inhibition, since at 0.25 and 2.5 microM media folate no depletion occurred in response to methotrexate and only slight depletion was observed at 50 microM media folate.	Folic Acid	68-74	thymidylate synthase	Mus musculus	17-37
3339615-0	1988	Inhibition of murine thymidylate synthase and human dihydrofolate reductase by 5,8-dideaza analogues of folic acid and aminopterin.	Folic Acid	104-114	thymidylate synthase	Mus musculus	21-41
3016548-1	1986	Methotrexate, a folate antagonist, blocks import into mitochondria of mouse dihydrofolate reductase fused to a mitochondrial presequence.	Folic Acid	16-22	dihydrofolate reductase	Mus musculus	76-99
3009301-8	1986	This pattern of B greater than A greater than C is the same as found for the modulation of ACP1 by purines and folates.	Folic Acid	111-118	acid phosphatase 1	Homo sapiens	91-95
3953656-2	1986	Chromosome anomalies were identified in 3: 2 had the heritable folate sensitive fra(2) (q13) site and 1 had an inv(9) (p11q12).	Folic Acid	63-69	FOS like 2, AP-1 transcription factor subunit	Homo sapiens	80-86
2887178-3	1985	Biochemical investigation of these patients after loading with L-histidine led to the conclusions that low histidase activity in stratum corneum was connected with: disturbances in folic acid metabolism (2 cases); "atypical histidinemia" (1 case); heterozygotes of histidinemia (2 cases); normal liver histidine metabolism but abnormal in other tissues (18 cases); previously unknown error of histidine metabolism (1 case).	Folic Acid	181-191	histidine ammonia-lyase	Homo sapiens	107-116
6490627-1	1984	Dimethylglycine dehydrogenase (EC 1.5.99.2) and sarcosine dehydrogenase (EC 1.5.99.1) are the folate binding proteins of rat liver mitochondria.	Folic Acid	94-100	dimethylglycine dehydrogenase	Rattus norvegicus	0-29
6486795-0	1984	Covalent binding of folic acid to dimethylglycine dehydrogenase.	Folic Acid	20-30	dimethylglycine dehydrogenase	Homo sapiens	34-63
6486795-4	1984	It is reported that folic acid may be covalently linked to dimethylglycine dehydrogenase in a specific and saturable manner so that only 1 mole of folic acid is bound per mole of enzyme.	Folic Acid	20-30	dimethylglycine dehydrogenase	Homo sapiens	59-88
6486795-4	1984	It is reported that folic acid may be covalently linked to dimethylglycine dehydrogenase in a specific and saturable manner so that only 1 mole of folic acid is bound per mole of enzyme.	Folic Acid	147-157	dimethylglycine dehydrogenase	Homo sapiens	59-88
6189586-8	1983	These findings support a role for dihydrofolate reductase as a locus for competitive binding interactions between reduced folates and methotrexate that may be a basis for the ability of 5-formyltetrahydrofolate to prevent the biochemical effects of this antifolate.	Folic Acid	122-129	dihydrofolate reductase	Mus musculus	34-57
6192074-2	1983	On the basis of his response to folate treatment, a partially-reversible defect in the formation of activated formaldehyde in the reaction catalyzed by sarcosine dehydrogenase was considered to be the most likely site.	Folic Acid	32-38	sarcosine dehydrogenase	Homo sapiens	152-175
6821190-7	1982	The fact that the folate binding proteins in rat liver mitochondria are two enzymes, dimethylglycine dehydrogenase and sarcosine dehydrogenase, suggests that enzyme activities may eventually be discovered for the other intracellular folate binding proteins.	Folic Acid	18-24	dimethylglycine dehydrogenase	Rattus norvegicus	85-114
11266438-1	2001	The reduced folate carrier (RFC1) is an important route by which the major blood folate, 5-methyltetrahydrofolate, is transported into mammalian cells.	Folic Acid	12-18	replication factor C subunit 1	Homo sapiens	28-32
11266438-1	2001	The reduced folate carrier (RFC1) is an important route by which the major blood folate, 5-methyltetrahydrofolate, is transported into mammalian cells.	Folic Acid	81-87	replication factor C subunit 1	Homo sapiens	28-32
11241661-0	2001	The rate of folate receptor alpha (FR alpha) synthesis in folate depleted CHL cells is regulated by a translational mechanism sensitive to media folate levels, while stable overexpression of its mRNA is mediated by gene amplification and an increase in transcript half-life.	Folic Acid	58-64	folate receptor alpha	Cricetulus griseus	12-33
11274424-1	2001	Low folate intake as well as alterations in folate metabolism as a result of polymorphisms in the enzyme methylenetetrahydrofolate reductase (MTHFR) have been associated with an increased incidence of neural tube defects, vascular disease, and some cancers.	Folic Acid	4-10	methylenetetrahydrofolate reductase	Homo sapiens	105-140
11274424-1	2001	Low folate intake as well as alterations in folate metabolism as a result of polymorphisms in the enzyme methylenetetrahydrofolate reductase (MTHFR) have been associated with an increased incidence of neural tube defects, vascular disease, and some cancers.	Folic Acid	4-10	methylenetetrahydrofolate reductase	Homo sapiens	142-147
11274424-1	2001	Low folate intake as well as alterations in folate metabolism as a result of polymorphisms in the enzyme methylenetetrahydrofolate reductase (MTHFR) have been associated with an increased incidence of neural tube defects, vascular disease, and some cancers.	Folic Acid	44-50	methylenetetrahydrofolate reductase	Homo sapiens	105-140
11274424-1	2001	Low folate intake as well as alterations in folate metabolism as a result of polymorphisms in the enzyme methylenetetrahydrofolate reductase (MTHFR) have been associated with an increased incidence of neural tube defects, vascular disease, and some cancers.	Folic Acid	44-50	methylenetetrahydrofolate reductase	Homo sapiens	142-147
11257268-0	2001	Influence of a methionine synthase (D919G) polymorphism on plasma homocysteine and folate levels and relation to risk of myocardial infarction.	Folic Acid	83-89	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	15-34
11257268-1	2001	Methionine synthase (MS) encodes an enzyme that catalyzes the remethylation of homocysteine to methionine using a methyl group donated by 5-methyltetrahydrofolate, which is the major circulating form of folate in the body.	Folic Acid	156-162	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	0-19
11257268-1	2001	Methionine synthase (MS) encodes an enzyme that catalyzes the remethylation of homocysteine to methionine using a methyl group donated by 5-methyltetrahydrofolate, which is the major circulating form of folate in the body.	Folic Acid	156-162	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	21-23
11257268-2	2001	Functional genetic variants of the MS may alter total homocysteine (tHcy) as well as folate levels which are independent risk factors for vascular disease.	Folic Acid	85-91	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	35-37
11257268-3	2001	The influence of a common genetic polymorphism (2756A--&gt;G, D919G) of the MS gene on plasma tHcy and folate levels and its relation to the risk of myocardial infarction (MI) in a prospective study of male physicians in the US was investigated.	Folic Acid	103-109	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	76-78
11257268-8	2001	The MS polymorphism was associated with decreased tHcy (10.55, 9.87 and 9.57 nmol/ml for DD, DG and GG genotypes, respectively) and increased folate levels (3.95, 3.78, 7.31 ng/ml for DD, DG and GG genotypes, respectively) only among controls but not cases.	Folic Acid	142-148	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	4-6
11257268-9	2001	It was concluded that influence of the MS (D919G) polymorphism on the plasma tHcy and folate levels is at most moderate, but should be further investigated in other large prospective studies.	Folic Acid	86-92	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	39-41
11170082-3	2001	Because of MTHFR"s involvement in the metabolism of folate, we investigated 64 CL/P patients and their parents for C677T MTHFR mutation.	Folic Acid	52-58	methylenetetrahydrofolate reductase	Homo sapiens	11-16
11161947-2	2001	Individuals homozygous for the methylenetetrahydrofolate reductase (MTHFR) 677C allele exclusively accumulate 5methyltetrahydrofolate, the methyl donor for homocysteine remethylation, in their red blood cells; this contrasts with 677 TT homozygotes who also accumulate significant levels of non-methylated folate derivatives.	Folic Acid	50-56	methylenetetrahydrofolate reductase	Homo sapiens	68-73
11161947-3	2001	Those with the MTHFR 677 TT, CT and CC genotypes may therefore differ qualitatively with respect to folate utilization and hence their capacity to remethylate homocysteine.	Folic Acid	100-106	methylenetetrahydrofolate reductase	Homo sapiens	15-20
11169018-3	2001	Furthermore, compound heterozygosity for the 677T allele and a novel A--&gt;C polymorphism at nucleotide position 1298 of MTHFR is suggested to correlate with a decrease of folate plasma concentrations.	Folic Acid	173-179	methylenetetrahydrofolate reductase	Homo sapiens	122-127
11139396-2	2001	We show that CB 3717/folate induces the expression of the hepatocyte growth factor (HGF)/c-Met signalling system in injured kidneys in which a significant, but transient, elevation of the HGF mRNA level occurs.	Folic Acid	21-27	hepatocyte growth factor	Mus musculus	58-82
11139396-2	2001	We show that CB 3717/folate induces the expression of the hepatocyte growth factor (HGF)/c-Met signalling system in injured kidneys in which a significant, but transient, elevation of the HGF mRNA level occurs.	Folic Acid	21-27	hepatocyte growth factor	Mus musculus	84-87
11139396-2	2001	We show that CB 3717/folate induces the expression of the hepatocyte growth factor (HGF)/c-Met signalling system in injured kidneys in which a significant, but transient, elevation of the HGF mRNA level occurs.	Folic Acid	21-27	hepatocyte growth factor	Mus musculus	188-191
12083967-1	2001	5,10-Methylenetetrahydrofolate reductase (MTHFR) plays a key role in folate metabolism by channeling one-carbon units between nucleotide synthesis and methylation reactions.	Folic Acid	24-30	methylenetetrahydrofolate reductase	Homo sapiens	42-47
12083967-8	2001	Colonic cancer and acute leukemia, however, appear to be less frequent in individuals homozygous for the 677T polymorphism.MTHFR polymorphisms influence the homocysteine-lowering effect of folates and could modify the pharmacodynamics of antifolates and many other drugs whose metabolism, biochemical effects, or target structures require methylation reactions.	Folic Acid	189-196	methylenetetrahydrofolate reductase	Homo sapiens	123-128
11299748-2	2001	Methylenetetrahydrofolate reductase (MTHFR) plays a role in the metabolism of folate.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
11299748-4	2001	We analyzed the association between MTHFR genotype and the folate pool in gastrointestinal cancer tissues.	Folic Acid	59-65	methylenetetrahydrofolate reductase	Homo sapiens	36-41
11299748-16	2001	These results suggest a link between MTHFR genotype and the folate pool in gastrointestinal cancer, leading to the association of MTHFR genotype with TS inhibition rate upon 5-FU exposure.	Folic Acid	60-66	methylenetetrahydrofolate reductase	Homo sapiens	37-42
11299748-16	2001	These results suggest a link between MTHFR genotype and the folate pool in gastrointestinal cancer, leading to the association of MTHFR genotype with TS inhibition rate upon 5-FU exposure.	Folic Acid	60-66	methylenetetrahydrofolate reductase	Homo sapiens	130-135
12044312-5	2001	Patients who were found to be homozygotes for the methylenetetrahydrofolate reductase mutation also received folic acid supplementation throughout their pregnancy.	Folic Acid	109-119	methylenetetrahydrofolate reductase	Homo sapiens	50-85
11523237-8	2001	A strong inverse correlation was found between folate or vitamin B12 and plasma Hcy levels according to MTHFR genotype (P &lt; 0.01).	Folic Acid	47-53	methylenetetrahydrofolate reductase	Homo sapiens	104-109
11468972-7	2001	The procedure recommended for the prevention of effects of deficiency of MTHFR activity consists of the supplementation of the diet with 0.4 mg of folic acid daily.	Folic Acid	147-157	methylenetetrahydrofolate reductase	Homo sapiens	73-78
11464627-3	2001	Methylenetetrahydrofolate reductase enzyme (MTHFR) plays an important role in folate metabolism.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	44-49
11204578-0	2001	Relationships between homocysteine, folate and vitamin B12 levels with the methylenetetrahydrofolate reductase polymorphism, in Indians from Western Venezuela.	Folic Acid	36-42	methylenetetrahydrofolate reductase	Homo sapiens	75-110
7446528-4	1980	The TIC-1 variant is activated by adenine and inhibited by folic acid to the same extent as the type-A enzyme, while the stimulation of the activity of the TIC-1 enzyme by hypoxanthine and the inhibition of it by uric acid is similar to that for the B enzyme.	Folic Acid	59-69	SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1	Homo sapiens	4-9
28523-0	1978	Interaction of methotrexate, folates, and pyridine nucleotides with dihydrofolate reductase: calorimetric and spectroscopic binding studies.	Folic Acid	29-36	dihydrofolate reductase	Gallus gallus	68-91
14121660-0	1964	INHIBITION OF ALCOHOL DEHYDROGENASE BY FOLIC ACID AND SEVERAL OF ITS ANALOGS.	Folic Acid	39-49	aldo-keto reductase family 1 member A1	Homo sapiens	14-35
24538112-0	1950	[Research in the relation between the defense action of certain antianemic substances (vitamin B12, pteroylglutamic acid) and the cholinesterase effect of the serum in experimental anemia of the rat].	Folic Acid	100-120	butyrylcholinesterase	Rattus norvegicus	130-144
34007312-1	2021	MTHFD2 is a folate-coupled mitochondrial metabolic enzyme which has been extensively studied in breast cancer; however, its molecular functions in this cancer remain unclear.	Folic Acid	12-18	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	Homo sapiens	0-6
34045473-10	2021	In summary, the data of this study showed that minor allele (A) of rs55763075 polymorphisms in the 3"-untranslated region of MTHFR mRNA generated a potential binding site for miR-34b, which led to reduced level of folic acid in the patients carrying the AA genotype.	Folic Acid	214-224	methylenetetrahydrofolate reductase	Homo sapiens	125-130
33979572-8	2021	These findings suggested that PGA could be a therapeutic drug candidate for the treatment of recurrent GBM by targeting the ELK1-SRF complex.	Folic Acid	30-33	serum response factor	Homo sapiens	129-132
34036101-3	2021	Methylenetetrahydrofolate reductase (MTHFR) gene mutation is related to elevated total homocysteine (tHct) expressions, in particular, among women with low folate intake.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
34047483-0	2021	A folate/RGD-dual-functionalized mesoporous silica nanoparticles targeting GABA-p38 MAPK-MRTFs/SRF signaling pathway in rheumatoid arthritis.	Folic Acid	2-8	serum response factor	Homo sapiens	95-98
33914208-1	2021	PURPOSE: MTHFR, one of the major enzymes in the folate cycle, is known to acquire single-nucleotide polymorphisms that significantly reduce its activity, resulting in an increase in circulating homocysteine.	Folic Acid	48-54	methylenetetrahydrofolate reductase	Homo sapiens	9-14
33859051-2	2021	In this prospective, multicentre cohort study, we investigated the association with treatment effectiveness and toxicity of 10 polymorphisms in nine candidate genes, covering the folate pathway (MTHFR), cell transport (SLC19A1/ABCC2/ABCC4), intracellular metabolism (FPGS/GGH) and target enzymes (TYMS/DHFR/ATIC) of pemetrexed.	Folic Acid	179-185	methylenetetrahydrofolate reductase	Homo sapiens	195-200
33497860-8	2021	While compared with the control group, the expression levels of HO-1 and CHOP protein were significantly increased in the lead exposure group (P < 0.05), and the expression levels of HO-1 and CHOP protein were significantly reduced in the folic acid intervention group (P < 0.05).	Folic Acid	239-249	heme oxygenase 1	Rattus norvegicus	183-187
33497860-10	2021	Folic acid down-regulated the expression levels of HO-1 and CHOP proteins through the two pathways of NrF2/HO-1 and GRP78/CHOP, thereby exerting a certain protective effect and alleviating the spleen caused by lead-induced oxidative stress and endoplasmic reticulum stress damage.	Folic Acid	0-10	heme oxygenase 1	Rattus norvegicus	51-55
33497860-10	2021	Folic acid down-regulated the expression levels of HO-1 and CHOP proteins through the two pathways of NrF2/HO-1 and GRP78/CHOP, thereby exerting a certain protective effect and alleviating the spleen caused by lead-induced oxidative stress and endoplasmic reticulum stress damage.	Folic Acid	0-10	heme oxygenase 1	Rattus norvegicus	107-111
11156393-11	2000	Comparison of individuals with and without Ki-ras mutations revealed that individuals with low levels of dietary folate (OR, 0.7; 95% CI, 0.4-1.3), vitamin B6 (OR, 0.5; 95% CI, 0.3-1.0), vitamin B12 (OR, 0.6; 95% CI, 0.3-1.1), and high levels of alcohol (OR, 0.7; 95% CI, 0.4-1.1) were less likely to have a 2G--&gt;A mutation.	Folic Acid	113-119	KRAS proto-oncogene, GTPase	Homo sapiens	43-49
11177206-15	2000	Thus, the interaction of dietary folate with the MTHFR genotype in the French population needs further study.	Folic Acid	33-39	methylenetetrahydrofolate reductase	Homo sapiens	49-54
11098041-2	2000	The most common inborn error of folate metabolism is mild methylenetetrahydrofolate reductase (MTHFR) deficiency due to the synthesis of a thermolabile variant of the enzyme with impaired catalytic activity which leads to reduced 5-methyltetrahydrofolate (5-methyl-THF) and mildly elevated homocysteine plasma concentrations when folate status is inadequate.	Folic Acid	32-38	methylenetetrahydrofolate reductase	Homo sapiens	58-93
11098041-2	2000	The most common inborn error of folate metabolism is mild methylenetetrahydrofolate reductase (MTHFR) deficiency due to the synthesis of a thermolabile variant of the enzyme with impaired catalytic activity which leads to reduced 5-methyltetrahydrofolate (5-methyl-THF) and mildly elevated homocysteine plasma concentrations when folate status is inadequate.	Folic Acid	32-38	methylenetetrahydrofolate reductase	Homo sapiens	95-100
11098041-2	2000	The most common inborn error of folate metabolism is mild methylenetetrahydrofolate reductase (MTHFR) deficiency due to the synthesis of a thermolabile variant of the enzyme with impaired catalytic activity which leads to reduced 5-methyltetrahydrofolate (5-methyl-THF) and mildly elevated homocysteine plasma concentrations when folate status is inadequate.	Folic Acid	77-83	methylenetetrahydrofolate reductase	Homo sapiens	95-100
11147289-9	2000	The study of folate and its association with NTDs is an ongoing endeavor that has led to numerous studies of different genes involved in the folate metabolism pathway, including the most commonly studied thermolabile mutation (C677T) in the MTHFR gene.	Folic Acid	13-19	methylenetetrahydrofolate reductase	Homo sapiens	241-246
11147289-9	2000	The study of folate and its association with NTDs is an ongoing endeavor that has led to numerous studies of different genes involved in the folate metabolism pathway, including the most commonly studied thermolabile mutation (C677T) in the MTHFR gene.	Folic Acid	141-147	methylenetetrahydrofolate reductase	Homo sapiens	241-246
11092508-1	2000	Individuals who are homozygous for the methylenetetrahydrofolate reductase (MTHFR) 677C --&gt; T mutation have depressed serum folate (SF) and elevated plasma total homocysteine (tHcy) concentrations, which may affect folate requirements and increase the risk for coronary artery disease.	Folic Acid	58-64	methylenetetrahydrofolate reductase	Homo sapiens	76-81
11092508-1	2000	Individuals who are homozygous for the methylenetetrahydrofolate reductase (MTHFR) 677C --&gt; T mutation have depressed serum folate (SF) and elevated plasma total homocysteine (tHcy) concentrations, which may affect folate requirements and increase the risk for coronary artery disease.	Folic Acid	127-133	methylenetetrahydrofolate reductase	Homo sapiens	39-74
11092508-1	2000	Individuals who are homozygous for the methylenetetrahydrofolate reductase (MTHFR) 677C --&gt; T mutation have depressed serum folate (SF) and elevated plasma total homocysteine (tHcy) concentrations, which may affect folate requirements and increase the risk for coronary artery disease.	Folic Acid	127-133	methylenetetrahydrofolate reductase	Homo sapiens	76-81
11092508-8	2000	These data suggest that older women who are homozygous for the MTHFR 677C --&gt; T mutation may be at risk for greater elevations in plasma tHcy in response to moderately low folate intake as compared with individuals with the normal or heterozygous genotypes.	Folic Acid	175-181	methylenetetrahydrofolate reductase	Homo sapiens	63-68
33497860-10	2021	Folic acid down-regulated the expression levels of HO-1 and CHOP proteins through the two pathways of NrF2/HO-1 and GRP78/CHOP, thereby exerting a certain protective effect and alleviating the spleen caused by lead-induced oxidative stress and endoplasmic reticulum stress damage.	Folic Acid	0-10	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	116-121
33635721-0	2021	Folic acid ameliorates neonatal isolation-induced autistic like behaviors in rats: Epigenetic modifications of BDNF and GFAP promotors".	Folic Acid	0-10	brain-derived neurotrophic factor	Rattus norvegicus	111-115
33635721-0	2021	Folic acid ameliorates neonatal isolation-induced autistic like behaviors in rats: Epigenetic modifications of BDNF and GFAP promotors".	Folic Acid	0-10	glial fibrillary acidic protein	Rattus norvegicus	120-124
33635721-10	2021	Folic acid administration concurrently with isolation, reduced neonatal isolation-induced autistic-like behaviors, decreased oxidative stress, regained BDNF and GFAP gene methylation, ameliorated structural changes in the frontal cortices of isolated folic acid treated rats.	Folic Acid	0-10	brain-derived neurotrophic factor	Rattus norvegicus	152-156
33635721-10	2021	Folic acid administration concurrently with isolation, reduced neonatal isolation-induced autistic-like behaviors, decreased oxidative stress, regained BDNF and GFAP gene methylation, ameliorated structural changes in the frontal cortices of isolated folic acid treated rats.	Folic Acid	0-10	glial fibrillary acidic protein	Rattus norvegicus	161-165
33635721-12	2021	Molecular and biochemical analyses showed that -NI induces DNA hypomethylation of BDNF and GFAP, increased oxidative stress markers, and neuroinflammation -All of these changes were reversed by daily folic acid supplementation.	Folic Acid	200-210	brain-derived neurotrophic factor	Rattus norvegicus	82-86
33635721-12	2021	Molecular and biochemical analyses showed that -NI induces DNA hypomethylation of BDNF and GFAP, increased oxidative stress markers, and neuroinflammation -All of these changes were reversed by daily folic acid supplementation.	Folic Acid	200-210	glial fibrillary acidic protein	Rattus norvegicus	91-95
33486813-2	2021	The conversion of folic acid into folate is catalysed by the methylenetetrahydrofolate (MTHFR) enzyme which is encoded by the MTHFR gene.	Folic Acid	18-28	methylenetetrahydrofolate reductase	Homo sapiens	88-93
33486813-2	2021	The conversion of folic acid into folate is catalysed by the methylenetetrahydrofolate (MTHFR) enzyme which is encoded by the MTHFR gene.	Folic Acid	18-28	methylenetetrahydrofolate reductase	Homo sapiens	126-131
33486813-2	2021	The conversion of folic acid into folate is catalysed by the methylenetetrahydrofolate (MTHFR) enzyme which is encoded by the MTHFR gene.	Folic Acid	34-40	methylenetetrahydrofolate reductase	Homo sapiens	88-93
33486813-2	2021	The conversion of folic acid into folate is catalysed by the methylenetetrahydrofolate (MTHFR) enzyme which is encoded by the MTHFR gene.	Folic Acid	34-40	methylenetetrahydrofolate reductase	Homo sapiens	126-131
33181482-9	2021	Combing with DEG, 14 couples of lncRNAs and their target genes were both DE, and 6 of them including CCDC39, KCNJ16, NECTIN2, MRPL20, PSMC4, and DEFB112 show their potential infertility-related terms such as cellular motility, sperm maturation, sperm storage, cellular junction, folate metabolism, and capacitation.	Folic Acid	279-285	coiled-coil domain containing 39	Bos taurus	101-107
33181482-9	2021	Combing with DEG, 14 couples of lncRNAs and their target genes were both DE, and 6 of them including CCDC39, KCNJ16, NECTIN2, MRPL20, PSMC4, and DEFB112 show their potential infertility-related terms such as cellular motility, sperm maturation, sperm storage, cellular junction, folate metabolism, and capacitation.	Folic Acid	279-285	mitochondrial ribosomal protein L20	Bos taurus	126-132
33181482-9	2021	Combing with DEG, 14 couples of lncRNAs and their target genes were both DE, and 6 of them including CCDC39, KCNJ16, NECTIN2, MRPL20, PSMC4, and DEFB112 show their potential infertility-related terms such as cellular motility, sperm maturation, sperm storage, cellular junction, folate metabolism, and capacitation.	Folic Acid	279-285	beta-defensin 112	Bos taurus	145-152
33440639-1	2021	Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the folate metabolic pathway, and its loss of function through polymorphisms is often associated with human conditions, including cancer, congenital heart disease, and Down syndrome.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
33497043-0	2021	A Association of MTHFR C677T and MTRR A66G Gene Polymorphisms with Iranian Male Infertility and Its Effect on Seminal Folate and Vitamin B12.	Folic Acid	118-124	methylenetetrahydrofolate reductase	Homo sapiens	17-22
33497043-2	2021	We aimed to determine whether 5, 10-methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase reductase (MTRR) A66G genotypes are associated with male infertility in Iranian men and to evaluate its effect on seminal levels of folate and vitamin B12.	Folic Acid	55-61	methylenetetrahydrofolate reductase	Homo sapiens	73-78
33168819-8	2020	Knockdown of MTHFD2 and MTHFR, two key enzymes in folate metabolism and methyl donor SAM production, significantly suppressed GC cell proliferation.	Folic Acid	50-56	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	Homo sapiens	13-19
33168819-8	2020	Knockdown of MTHFD2 and MTHFR, two key enzymes in folate metabolism and methyl donor SAM production, significantly suppressed GC cell proliferation.	Folic Acid	50-56	methylenetetrahydrofolate reductase	Homo sapiens	24-29
33168096-0	2020	Aldh1l2 knockout mouse metabolomics links the loss of the mitochondrial folate enzyme to deregulation of a lipid metabolism observed in rare human disorder.	Folic Acid	72-78	aldehyde dehydrogenase 1 family, member L2	Mus musculus	0-7
33157923-1	2020	Mutations in the methylenetetrahydrofolate reductase (MTHFR) gene can result in a reduced ability to utilize folic acid.	Folic Acid	109-119	methylenetetrahydrofolate reductase	Homo sapiens	17-52
33157923-1	2020	Mutations in the methylenetetrahydrofolate reductase (MTHFR) gene can result in a reduced ability to utilize folic acid.	Folic Acid	109-119	methylenetetrahydrofolate reductase	Homo sapiens	54-59
33157923-3	2020	This study aimed to evaluate the prevalence of the MTHFR 677C>T mutation among pregnant women in Yunnan Province so as to collect baseline data that may be utilized to guide folic acid supplementation efforts and to support related disease prevention programs.	Folic Acid	174-184	methylenetetrahydrofolate reductase	Homo sapiens	51-56
32451826-1	2020	5,10-Methylene-tetrahydrofolate reductase (MTHFR) deficiency is a rare, autosomal recessive, metabolic disorder of folate metabolism, which affects homocysteine remethylation.	Folic Acid	25-31	methylenetetrahydrofolate reductase	Homo sapiens	43-48
33179601-5	2020	The re-methylation reaction not only involves the enzymes methionine synthase and methionine synthase reductase but also depends on the cofactor cobalamin and on the provision of methyl groups from the folate cycle.	Folic Acid	202-208	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	58-77
32269290-11	2020	Further missense or frameshift mutations were observed in the KRAS, APC, TP53, and CTNNB1 genes in the PGA group.	Folic Acid	103-106	KRAS proto-oncogene, GTPase	Homo sapiens	62-66
32972375-2	2020	Methylenetetrahydrofolate reductase (MTHFR) has a significant role in folate metabolism.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
32903271-4	2020	Knockdown of SHMT2 expression in vitro caused a state of glycine auxotrophy and accumulation of phosphoribosylaminoimidazolecarboxamide (AICAR), an intermediate of folate/1-carbon-pathway-dependent de novo purine nucleotide synthesis.	Folic Acid	164-170	serine hydroxymethyltransferase 2	Homo sapiens	13-18
32803503-8	2020	Folate and B12 deficiencies were observed in CAD cases, which were shown to contribute to hypomethylation and upregulation of the prime candidate genes i.e. CDKN2A and F2RL3.	Folic Acid	0-6	F2R like thrombin or trypsin receptor 3	Homo sapiens	168-173
32542792-0	2020	RIPK3 blockade attenuates kidney fibrosis in a folic acid model of renal injury.	Folic Acid	47-57	receptor-interacting serine-threonine kinase 3	Mus musculus	0-5
32542792-6	2020	Our studies identify that RIPK3 promotes renal fibrosis via the activation of the NLRP3 inflammasome in a mouse model of folic acid-induced nephropathy.	Folic Acid	121-131	receptor-interacting serine-threonine kinase 3	Mus musculus	26-31
32410296-1	2020	BACKGROUND: Polymorphisms (rs1801133 or C677T; rs1801131 or A1298C) of the MTHFR gene and rs1801394 (A66G) of the MTRR gene are important genetic determinants of folate metabolism.	Folic Acid	162-168	methylenetetrahydrofolate reductase	Homo sapiens	75-80
32774701-7	2020	Folic acid-induced injury of mesangial cells showed inhibited cell proliferation, promoted apoptosis, increased LC3II expression, decreased p62 expression, increased autophagic vacuoles and expression of STAT3 and p-mTOR as well as decreased E-cadherin expression and increased Vimentin expression.	Folic Acid	0-10	nucleoporin 62	Mus musculus	140-143
32774701-7	2020	Folic acid-induced injury of mesangial cells showed inhibited cell proliferation, promoted apoptosis, increased LC3II expression, decreased p62 expression, increased autophagic vacuoles and expression of STAT3 and p-mTOR as well as decreased E-cadherin expression and increased Vimentin expression.	Folic Acid	0-10	vimentin	Mus musculus	278-286
32353563-1	2020	In eucaryotic cells, methionine synthase reductase (MSR/MTRR) is capable of dominating the folate-homocysteine metabolism as an irreplaceable partner in electron transfer for regeneration of methionine synthase.	Folic Acid	91-97	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	21-40
32353563-1	2020	In eucaryotic cells, methionine synthase reductase (MSR/MTRR) is capable of dominating the folate-homocysteine metabolism as an irreplaceable partner in electron transfer for regeneration of methionine synthase.	Folic Acid	91-97	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	191-210
32611627-0	2020	MGMT Promoter Methylation as a Target In Metastatic Colorectal Cancer: Rapid Turnover and Use of Folates Alter its Study-Letter.	Folic Acid	97-104	O-6-methylguanine-DNA methyltransferase	Homo sapiens	0-4
32611628-0	2020	MGMT Promoter Methylation as a Target In Metastatic Colorectal Cancer: Rapid Turnover and Use of Folates Alter its Study-Response.	Folic Acid	97-104	O-6-methylguanine-DNA methyltransferase	Homo sapiens	0-4
33274184-4	2020	We analyzed three functional folate gene variants, namely 5-methyltetrahydrofolate-homocysteine methyltransferase rs1805087, 5-methyltetrahydrofolate-homocysteine methyltransferase reductase rs1801394, and reduced folate carrier 1 rs1051266, for contribution in the etiology of DS.	Folic Acid	29-35	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	58-113
32379616-1	2020	BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is the key enzyme of folate metabolism in the process of one-carbon cycle and its deficiency results in elevated homocysteine concentration.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	49-54
32549258-2	2020	Homocysteine (Hcy), a sulfur-aminoacid whose serum level is regulated by methylenetrahydrofolate reductase (MTHFR) activity and vitamin B12 and folate as cofactors, is a risk factor for inflammatory diseases.	Folic Acid	90-96	methylenetetrahydrofolate reductase	Homo sapiens	108-113
32498709-2	2020	We thus wished to determine whether the inefficiency in folate metabolism caused by genetic variation in the MTHFR and DHFR genes in folate metabolism, or inadequate folate intake, is associated with obesity.	Folic Acid	56-62	methylenetetrahydrofolate reductase	Homo sapiens	109-114
32498709-2	2020	We thus wished to determine whether the inefficiency in folate metabolism caused by genetic variation in the MTHFR and DHFR genes in folate metabolism, or inadequate folate intake, is associated with obesity.	Folic Acid	133-139	methylenetetrahydrofolate reductase	Homo sapiens	109-114
32498709-2	2020	We thus wished to determine whether the inefficiency in folate metabolism caused by genetic variation in the MTHFR and DHFR genes in folate metabolism, or inadequate folate intake, is associated with obesity.	Folic Acid	133-139	methylenetetrahydrofolate reductase	Homo sapiens	109-114
32334045-2	2020	Riboflavin (FAD) is a cofactor for methylenetetrahydrofolate reductase (MTHFR), a critical enzyme in folate recycling, which generates methyl groups for homocysteine remethylation to methionine, the pre-cursor to the universal methyl donor S-adenosylmethionine (SAM).	Folic Acid	54-60	methylenetetrahydrofolate reductase	Homo sapiens	72-77
32390395-4	2020	MTHFR is the key enzyme in folic acid metabolism, thus, it influences the production of the main donor of methyl groups for DNA methylation.	Folic Acid	27-37	methylenetetrahydrofolate reductase	Homo sapiens	0-5
32167962-8	2020	Also, the inverse association were observed between risk of CRA and the index of nutritional quality of calcium, vitamin C, riboflavin, folate and fiber [OR calcium: 0.32 (0.14-0.74), ORvitC: 0.51 (0.34-0.73), ORvitB2: 0.48 (0.28-0.82), OR folate: 0.44 (0.23-0.81), OR fiber: 0.62 (0.42-0.92)].	Folic Acid	136-142	myotubularin related protein 11	Homo sapiens	60-63
32167962-8	2020	Also, the inverse association were observed between risk of CRA and the index of nutritional quality of calcium, vitamin C, riboflavin, folate and fiber [OR calcium: 0.32 (0.14-0.74), ORvitC: 0.51 (0.34-0.73), ORvitB2: 0.48 (0.28-0.82), OR folate: 0.44 (0.23-0.81), OR fiber: 0.62 (0.42-0.92)].	Folic Acid	240-246	myotubularin related protein 11	Homo sapiens	60-63
31932513-5	2020	Over a median of 4.5 years, among those not receiving folic acid, participants with baseline serum B12 or serum folate above the median had a significantly lower risk of first ischemic stroke (hazard ratio [HR], 0.74; 95% confidence interval [CI], 0.57-0.96), especially in those with MTHFR 677 CC genotype (wild-type) (HR, 0.49; 95% CI, 0.31-0.78).	Folic Acid	112-118	methylenetetrahydrofolate reductase	Homo sapiens	285-290
31932513-6	2020	Folic acid treatment significantly reduced the risk of first ischemic stroke in participants with both folate and B12 below the median (2.3% in enalapril-folic acid group vs 3.6% in enalapril-only group; HR, 0.62; 95% CI, 0.46-0.86), particularly in MTHFR 677 CC carriers (1.6% vs 4.9%; HR, 0.24; 95% CI, 0.11-0.55).	Folic Acid	0-10	methylenetetrahydrofolate reductase	Homo sapiens	250-255
31883219-9	2020	Meanwhile, both the CCR7lo PD-1hi subset and intracellular IL-21 expression in IIM patients showed significantly positive correlation with PGA VAS, muscle VAS and serum CK levels.	Folic Acid	139-142	interleukin 21	Homo sapiens	59-64
32003962-3	2020	In our approach, we prepared crosslinked polyethylenimine (PEI) NGs via an inverse emulsion method, modified the PEI NGs with Gd chelates, targeting ligand folic acid (FA) through a polyethylene glycol (PEG) spacer and 1, 3-propanesultone (1, 3-PS), and finally loaded CuS nanoparticles (NPs) within the functional NGs.	Folic Acid	156-166	mesoderm specific transcript	Homo sapiens	182-220
29848222-2	2020	Excess (10-fold) intakes of folic acid in the gestational diet have been linked to increased food intake and obesity in male rat offspring post-weaning.Objective: The present study examined the effects of folic acid content in gestational diets on the development and function of two hypothalamic neuronal populations, neuropeptide Y (NPY) and pro-opiomelanocortin (POMC), within food intake regulatory pathways of male Wistar rat offspring at birth and post-weaning.Results: Folic acid fed at 5.0-fold above recommended levels (5RF) to Wistar dams during pregnancy increased the number of mature NPY-positive neurons in the hypothalamus of male offspring, compared to control (RF), 0RF, 2.5RF, and 10RF at birth.	Folic Acid	28-38	proopiomelanocortin	Rattus norvegicus	344-364
29848222-2	2020	Excess (10-fold) intakes of folic acid in the gestational diet have been linked to increased food intake and obesity in male rat offspring post-weaning.Objective: The present study examined the effects of folic acid content in gestational diets on the development and function of two hypothalamic neuronal populations, neuropeptide Y (NPY) and pro-opiomelanocortin (POMC), within food intake regulatory pathways of male Wistar rat offspring at birth and post-weaning.Results: Folic acid fed at 5.0-fold above recommended levels (5RF) to Wistar dams during pregnancy increased the number of mature NPY-positive neurons in the hypothalamus of male offspring, compared to control (RF), 0RF, 2.5RF, and 10RF at birth.	Folic Acid	28-38	proopiomelanocortin	Rattus norvegicus	366-370
31740010-10	2019	This study supported the hypothesis that, in Thais, low folate status is associated with a higher risk of CRC, particularly among those with polymorphisms of the MTHFR 677C > T and MTR 2756 A > G genes.	Folic Acid	56-62	methylenetetrahydrofolate reductase	Homo sapiens	162-167
31328769-9	2019	In addition, MTTP mRNA abundance was higher in the liver of birds subjected to folic acid (P < 0.05).	Folic Acid	79-89	microsomal triglyceride transfer protein	Homo sapiens	13-17
31504085-8	2019	RESULTS: In women, higher dietary vitamin intake [vitamin A, beta-carotene, folic acid, vitamin C (VC), vitamin D, and vitamin E] was significantly associated with lower mean ABCA1 DNA methylation levels (P = 0.004, 0.03, 0.005, 0.001, 0.03, and 0.04, respectively).	Folic Acid	76-86	ATP binding cassette subfamily A member 1	Homo sapiens	175-180
31593741-0	2019	Nilotinib Ameliorates Folic Acid-Induced Acute Kidney Injury Through Modulation of TWEAK and HSP-70 Pathways.	Folic Acid	22-32	TNF superfamily member 12	Homo sapiens	83-88
31593741-0	2019	Nilotinib Ameliorates Folic Acid-Induced Acute Kidney Injury Through Modulation of TWEAK and HSP-70 Pathways.	Folic Acid	22-32	heat shock protein family A (Hsp70) member 4	Homo sapiens	93-99
31624291-1	2019	ALDH1L1 (10-formyltetrahydrofolate dehydrogenase), an enzyme of folate metabolism highly expressed in liver, metabolizes 10-formyltetrahydrofolate to produce tetrahydrofolate (THF).	Folic Acid	28-34	aldehyde dehydrogenase 1 family, member L1	Mus musculus	0-7
31209892-4	2019	Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2), a mitochondrial enzyme involved in folic acid metabolism, interestingly was confirmed to be one of the target genes of miR-33a-5p in the present study.	Folic Acid	87-97	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	Homo sapiens	0-41
31209892-4	2019	Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2), a mitochondrial enzyme involved in folic acid metabolism, interestingly was confirmed to be one of the target genes of miR-33a-5p in the present study.	Folic Acid	87-97	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	Homo sapiens	43-49
31405972-2	2019	Folate transport is mediated by 3 major pathways, reduced folate carrier (RFC), proton-coupled folate transporter (PCFT), and folate receptor alpha (FRalpha/Folr1), known to be regulated by ligand-activated nuclear receptors.	Folic Acid	0-6	solute carrier family 46, member 1	Mus musculus	80-113
31405972-2	2019	Folate transport is mediated by 3 major pathways, reduced folate carrier (RFC), proton-coupled folate transporter (PCFT), and folate receptor alpha (FRalpha/Folr1), known to be regulated by ligand-activated nuclear receptors.	Folic Acid	0-6	solute carrier family 46, member 1	Mus musculus	115-119
31405972-3	2019	Cerebral folate delivery primarily occurs at the choroid plexus through FRalpha and PCFT; inactivation of these transport systems can result in very low folate levels in the cerebrospinal fluid causing childhood neurodegenerative disorders.	Folic Acid	9-15	solute carrier family 46, member 1	Mus musculus	84-88
31405972-5	2019	Our group has previously reported in vitro that functional expression of RFC at the blood-brain barrier (BBB) and its upregulation by the vitamin D nuclear receptor (VDR) could provide an alternative route for brain folate uptake.	Folic Acid	216-222	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	138-164
31405972-5	2019	Our group has previously reported in vitro that functional expression of RFC at the blood-brain barrier (BBB) and its upregulation by the vitamin D nuclear receptor (VDR) could provide an alternative route for brain folate uptake.	Folic Acid	216-222	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	166-169
31496738-1	2019	Purpose: Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is a tetramethylfolate dehydrogenase enzyme involved in folate metabolism.	Folic Acid	28-34	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	Homo sapiens	52-58
31396477-1	2019	Background: Methylenetetrahydrofolate reductase (MTHFR) gene is a crucial regulator of folate metabolism and its two prominent polymorphic variants C677T and A1298C lead to decreased MTHFR enzyme activity.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	49-54
31396477-1	2019	Background: Methylenetetrahydrofolate reductase (MTHFR) gene is a crucial regulator of folate metabolism and its two prominent polymorphic variants C677T and A1298C lead to decreased MTHFR enzyme activity.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	183-188
30693532-5	2019	Disruption of methionine synthase has wide-ranging implications for all methylation-dependent reactions, including epigenetic modification, but also for the intracellular folate pathway, since methionine synthase uses 5-methyltetrahydrofolate as a one-carbon donor.	Folic Acid	171-177	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	14-33
30693532-5	2019	Disruption of methionine synthase has wide-ranging implications for all methylation-dependent reactions, including epigenetic modification, but also for the intracellular folate pathway, since methionine synthase uses 5-methyltetrahydrofolate as a one-carbon donor.	Folic Acid	171-177	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	193-212
31171577-8	2019	Strikingly, the anterior cleft palate in Cbfb mutants is further rescued by pharmaceutical application of folic acid, which activates suppressed Stat3 phosphorylation and Tgfb3 expression in vitro With these findings, we provide the first evidence that Cbfb is a prerequisite for anterior palatogenesis and acts as an obligatory cofactor in the Runx1/Cbfb-Stat3-Tgfb3 signaling axis.	Folic Acid	106-116	runt related transcription factor 1	Mus musculus	345-350
31216671-0	2019	Association of Folate and Vitamins Involved in the 1-Carbon Cycle with Polymorphisms in the Methylenetetrahydrofolate Reductase Gene (MTHFR) and Global DNA Methylation in Patients with Colorectal Cancer.	Folic Acid	15-21	methylenetetrahydrofolate reductase	Homo sapiens	92-127
31216671-0	2019	Association of Folate and Vitamins Involved in the 1-Carbon Cycle with Polymorphisms in the Methylenetetrahydrofolate Reductase Gene (MTHFR) and Global DNA Methylation in Patients with Colorectal Cancer.	Folic Acid	15-21	methylenetetrahydrofolate reductase	Homo sapiens	134-139
31216671-2	2019	Thus, the objective of this study was to evaluate the association of folate and vitamins involved in the 1-carbon cycle and MTHFR polymorphisms in global DNA methylation in patients with colorectal cancer gene.	Folic Acid	69-75	methylenetetrahydrofolate reductase	Homo sapiens	124-129
31494266-7	2019	Moreover, significant genetic diversity in MTHFR, TCN2, FADS1, and FADS2, which associate with circulating folate, vitamin B12, or lipid metabolism, was observed between northerners and southerners.	Folic Acid	107-113	methylenetetrahydrofolate reductase	Homo sapiens	43-48
30941645-10	2019	MTHFR expression showed a strong positive correlation (r = 0.96, p &lt; 0.01) with folate levels in placenta.	Folic Acid	83-89	methylenetetrahydrofolate reductase	Homo sapiens	0-5
30878215-4	2019	MMP-7 was induced in renal tubules following ischemia/ reperfusion injury or cisplatin administration, and in folic acid-induced AKI.	Folic Acid	110-120	matrix metallopeptidase 7	Mus musculus	0-5
31975775-0	2019	Folic Acid Modulates Matrix Metalloproteinase-9 Expression Following Spinal Cord Injury.	Folic Acid	0-10	matrix metallopeptidase 9	Rattus norvegicus	21-47
30532069-2	2019	Here, we uncovered the critical role of folate-mediated one-carbon (1C) metabolism involving mitochondrial methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) and its downstream purine synthesis pathway.	Folic Acid	40-46	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	Homo sapiens	107-148
30532069-2	2019	Here, we uncovered the critical role of folate-mediated one-carbon (1C) metabolism involving mitochondrial methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) and its downstream purine synthesis pathway.	Folic Acid	40-46	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	Homo sapiens	150-156
30911005-0	2019	Enhancing folic acid metabolism suppresses defects associated with loss of Drosophila mitofusin.	Folic Acid	10-20	Mitochondrial assembly regulatory factor	Drosophila melanogaster	86-95
30911005-5	2019	Here, we have downregulated the expression of the Drosophila mitofusin (dMfn RNAi) in adult flies and showed that this activates mitochondrial retrograde signalling and is associated with an upregulation of genes involved in folic acid (FA) metabolism.	Folic Acid	225-235	Mitochondrial assembly regulatory factor	Drosophila melanogaster	61-70
30911005-5	2019	Here, we have downregulated the expression of the Drosophila mitofusin (dMfn RNAi) in adult flies and showed that this activates mitochondrial retrograde signalling and is associated with an upregulation of genes involved in folic acid (FA) metabolism.	Folic Acid	225-235	Mitochondrial assembly regulatory factor	Drosophila melanogaster	72-76
30529100-1	2019	MTHFR is a key enzyme in folate metabolism.	Folic Acid	25-31	methylenetetrahydrofolate reductase	Homo sapiens	0-5
30941303-5	2019	We aim to develop a CAR-T adaptor molecule (CAM)-based therapy that uses a bispecific small-molecule ligand EC17, fluorescein isothiocyanate (FITC) conjugated with folic acid, to redirect FITC-specific CAR-T cells against folate receptor (FR)-positive tumors.	Folic Acid	164-174	nuclear receptor subfamily 1 group I member 3	Homo sapiens	20-23
30891062-7	2019	Most of the functional categories altered by Gclc overexpression related to metabolism including Drug metabolism, Metabolism of xenobiotics by cytochrome P450, Glutathione metabolism, Starch and sucrose metabolism, Citrate cycle (TCA cycle), One carbon pool by folate.	Folic Acid	261-267	Glutamate-cysteine ligase catalytic subunit	Drosophila melanogaster	45-49
30611573-15	2019	CONCLUSIONS: We make the novel observation of increased GABA and PGA with decreased NAT in patients with MetS.	Folic Acid	65-68	bromodomain containing 2	Homo sapiens	84-87
31058257-0	2019	NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism.	Folic Acid	69-75	2,4-dienoyl-CoA reductase 1	Homo sapiens	0-5
31058257-7	2019	Across different cancer cell lines, G6PD deletion produced consistent changes in folate-related metabolites, suggesting a general requirement for the oxPPP to support folate metabolism.	Folic Acid	81-87	glucose-6-phosphate dehydrogenase	Homo sapiens	36-40
31058257-7	2019	Across different cancer cell lines, G6PD deletion produced consistent changes in folate-related metabolites, suggesting a general requirement for the oxPPP to support folate metabolism.	Folic Acid	167-173	glucose-6-phosphate dehydrogenase	Homo sapiens	36-40
30541852-6	2019	In this study, we have identified SLC19A1, the reduced folate carrier, as the cellular protein used as a receptor by the GLN retrovirus.	Folic Acid	55-61	solute carrier family 19 (folate transporter), member 1	Mus musculus	34-41
30541852-12	2019	It is SLC19A1, the reduced folate carrier.	Folic Acid	27-33	solute carrier family 19 (folate transporter), member 1	Mus musculus	6-13
30906627-0	2019	MicroRNA-940 inhibits glioma progression by blocking mitochondrial folate metabolism through targeting of MTHFD2.	Folic Acid	67-73	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	Homo sapiens	106-112
30906627-7	2019	Methylenetetrahydrofolate dehydrogenase (MTHFD2), a dual-functional metabolic enzyme, is involved in the one-carbon metabolism of folate in mitochondria.	Folic Acid	19-25	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	Homo sapiens	41-47
30372582-0	2018	The modifying effect of the MTHFR genotype on the association between folic acid supplementation and pulse wave velocity: Findings from the CSPPT.	Folic Acid	70-80	methylenetetrahydrofolate reductase	Homo sapiens	28-33
30372582-8	2018	The positive effect of folic acid on improved PWV was modified by the MTHFR genotype (P for interaction = 0.034).	Folic Acid	23-33	methylenetetrahydrofolate reductase	Homo sapiens	70-75
30098999-5	2018	Additionally, by knocking down folate transporter or pharmacologically inhibiting folate transport and metabolism, we observed ectopic Sox2 expression at the expense of neural crest markers in the dorsal neural tube.	Folic Acid	31-37	SRY-box transcription factor 2	Homo sapiens	135-139
30397195-1	2018	Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme for the critical process of one-carbon metabolism involving folate and homocysteine metabolisms.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
30397195-4	2018	It is also understudied on whether folate supplements could be an effective treatment for psychiatric patients with defect MTHFR activity.	Folic Acid	35-41	methylenetetrahydrofolate reductase	Homo sapiens	123-128
30397195-5	2018	In this review, we not only gathered the most recent discoveries on MTHFR polymorphism and related DNA methylation in various psychiatric disorders, but also highlighted the potential relationships between MTHFR activity and implication of folate-related function in specific mental diseases.	Folic Acid	240-246	methylenetetrahydrofolate reductase	Homo sapiens	68-73
30397195-5	2018	In this review, we not only gathered the most recent discoveries on MTHFR polymorphism and related DNA methylation in various psychiatric disorders, but also highlighted the potential relationships between MTHFR activity and implication of folate-related function in specific mental diseases.	Folic Acid	240-246	methylenetetrahydrofolate reductase	Homo sapiens	206-211
29702041-0	2018	Influence of the C677T Polymorphism of the MTHFR Gene on Oxidative Stress in Women With Overweight or Obesity: Response to a Dietary Folate Intervention.	Folic Acid	133-139	methylenetetrahydrofolate reductase	Homo sapiens	43-48
29702041-1	2018	The C677T polymorphism of the methylenetetrahydrofolate reductase gene (MTHFR) is related to folate metabolism and can alter the levels of biochemical markers.	Folic Acid	49-55	methylenetetrahydrofolate reductase	Homo sapiens	72-77
29702041-2	2018	OBJECTIVE: Investigate the influence of the MTHFR C677T polymorphism on the effects of a dietary folate intervention on oxidative stress in women with overweight or obesity.	Folic Acid	97-103	methylenetetrahydrofolate reductase	Homo sapiens	44-49
29702041-7	2018	CONCLUSIONS: The study demonstrated the beneficial effect of folate intake in terms of a TAC elevation for the CC and TT genotypes of the MTHFR C677T polymorphism, an increase in folic acid levels for all genotypes, and a reduction in the Hcy levels for the TT genotype in response to an intervention consisting of an intake of 191 microg/d of folate supplied by vegetables.	Folic Acid	61-67	methylenetetrahydrofolate reductase	Homo sapiens	138-143
29702041-7	2018	CONCLUSIONS: The study demonstrated the beneficial effect of folate intake in terms of a TAC elevation for the CC and TT genotypes of the MTHFR C677T polymorphism, an increase in folic acid levels for all genotypes, and a reduction in the Hcy levels for the TT genotype in response to an intervention consisting of an intake of 191 microg/d of folate supplied by vegetables.	Folic Acid	344-350	methylenetetrahydrofolate reductase	Homo sapiens	138-143
30402861-10	2018	However, the effects of Hcy on MDA level and expressions of SOD2, eNOS, and ICAM-1 were attenuated by folic acid (Fc) and vitamin B12 (B12) treatment.	Folic Acid	102-112	intercellular adhesion molecule 1	Homo sapiens	76-82
30198140-6	2018	Three folate genes (C677T-MTHFR, C1420T-SHMT, and 2R > 3R-TS) strengthen this effect in spring, and another (T401C-MTHFD) in summer.	Folic Acid	6-12	methylenetetrahydrofolate reductase	Homo sapiens	26-31
29380373-10	2018	Folic acid induced nephropathy was associated with the overexpression of inflammatory markers MCP-1, F4/80, type IV collagen, fibronectin and TGF-beta1 compared to control groups, which were partially attenuated by metformin treatment.	Folic Acid	0-10	adhesion G protein-coupled receptor E1	Mus musculus	101-124
29759484-8	2018	Specific deletion of Runx1 in mouse RTECs attenuated renal fibrosis, which was induced by both unilateral ureteral obstruction (UUO) and folic acid (FA) treatment.	Folic Acid	137-147	runt related transcription factor 1	Mus musculus	21-26
29185200-1	2018	BACKGROUND: Methylenetetrahyfrofolate reductase (MTHFR) is the key enzyme for one carbon and folate metabolism.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	49-54
29687876-0	2018	The intervention of enalapril maleate and folic acid tablet on the expressions of the GRP78 and CHOP and vascular remodeling in the vascular smooth muscle cells of H-hypertensive rats with homocysteine.	Folic Acid	42-52	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	86-91
29687876-2	2018	We aim to investigate the effect of enalapril maleate and folic acid tablet on the expressions of GRP78 and CHOP and vascular remodeling in a homocysteine (HCY)-treated hypertensive rat model.	Folic Acid	58-68	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	98-103
29687876-14	2018	The expressions of GRP78 and CHOP in methionine group were significantly elevated compared to that of control in a time dependent manner (p < 0.05), which were remarkably down regulated in enalapril maleate and folic acid tablet group compared with that in methionine group.	Folic Acid	211-221	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	19-24
30158810-1	2018	Aim: This study aimed to understand the association of gene-specific methylation of the promoter region of methylenetetrahydrofolate reductase (MTHFR) in the causation of recurrent miscarriages (RMs) both independently and also in light of MTHFR C677T polymorphism, hyperhomocysteinemia, folate, and Vitamin B12 deficiency.	Folic Acid	126-132	methylenetetrahydrofolate reductase	Homo sapiens	144-149
30158810-1	2018	Aim: This study aimed to understand the association of gene-specific methylation of the promoter region of methylenetetrahydrofolate reductase (MTHFR) in the causation of recurrent miscarriages (RMs) both independently and also in light of MTHFR C677T polymorphism, hyperhomocysteinemia, folate, and Vitamin B12 deficiency.	Folic Acid	126-132	methylenetetrahydrofolate reductase	Homo sapiens	240-245
29427165-1	2018	Polymorphisms in MTHFR gene are mostly associated with increased levels of homocysteine in the absence of dietary folate and are a risk factor for complex neurovascular diseases like migraine.	Folic Acid	114-120	methylenetetrahydrofolate reductase	Homo sapiens	17-22
29737822-0	2018	Effects of MTHFR A1298C polymorphism on peripheral blood folate concentration in healthy populations: a meta-analysis of observational studies.	Folic Acid	57-63	methylenetetrahydrofolate reductase	Homo sapiens	11-16
28821981-6	2018	For EAC, an increased risk was reported for smoking, body mass index, and red and processed meat consumption, while risk decreased with Helicobacter pylori infection, low/moderate alcohol drinking, physical activity, and consumption of fruit, vegetables, folate, fiber, beta-carotene, and vitamin C.	Folic Acid	255-261	CYLD lysine 63 deubiquitinase	Homo sapiens	4-7
29129231-11	2018	CONCLUSION: Women who consumed a healthier diet including vitamin A, beta-carotene, vitamin C, and folate and low-fat milk were at decreased risk for developing BrCa compared with those whose diet included more high fat and lamb meat.	Folic Acid	99-105	BRCA1 DNA repair associated	Homo sapiens	161-165
29340279-2	2017	Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) are the two key regulatory enzymes in the folate/homocysteine (Hcy) metabolism.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
29951428-12	2017	Conclusion: MTHFR genotype, independent of folate availability and probable confounding parameters, might be a potential risk factor of perceived stress among nurses.	Folic Acid	43-49	methylenetetrahydrofolate reductase	Homo sapiens	12-17
29225823-6	2017	Conclusion: These results show that the mitochondrial folate pathway isozymes MTHFD2 and MTHFD2L both exhibit dual redox cofactor specificity.	Folic Acid	54-60	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	Homo sapiens	78-84
29225823-6	2017	Conclusion: These results show that the mitochondrial folate pathway isozymes MTHFD2 and MTHFD2L both exhibit dual redox cofactor specificity.	Folic Acid	54-60	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like	Homo sapiens	89-96
29171783-8	2017	Western blots showed that HHcy induced a decreased expression of HES1 and HES5, or P62, in which the expression of HES1 and P62 was elevated by treating with folate and vitamin B12 supplement.	Folic Acid	158-164	hes family bHLH transcription factor 5	Mus musculus	74-78
29171783-8	2017	Western blots showed that HHcy induced a decreased expression of HES1 and HES5, or P62, in which the expression of HES1 and P62 was elevated by treating with folate and vitamin B12 supplement.	Folic Acid	158-164	nucleoporin 62	Mus musculus	83-86
29171783-8	2017	Western blots showed that HHcy induced a decreased expression of HES1 and HES5, or P62, in which the expression of HES1 and P62 was elevated by treating with folate and vitamin B12 supplement.	Folic Acid	158-164	nucleoporin 62	Mus musculus	124-127
28703660-8	2017	Conclusion Treatment with low-dose aspirin, enoxaparin and folic acid was the most effective therapy in women with RM who carried a C677T MTHFR mutation.	Folic Acid	59-69	methylenetetrahydrofolate reductase	Homo sapiens	138-143
29340017-4	2017	Results from mouse models indicated that the establishment of GNAS imprinting was influenced by both maternal and paternal folate-deficient diets.	Folic Acid	123-129	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	Mus musculus	62-66
29218045-3	2017	Here, flow cytometry assays were used to evaluate the effects of aHUS-related mutations on FH regulation of PGA formation and characterize the mechanism.	Folic Acid	108-111	complement factor H	Homo sapiens	91-93
29218045-6	2017	The role of FH in PGA formation was attributed to its ability to regulate AP-mediated C5a generation.	Folic Acid	18-21	complement factor H	Homo sapiens	12-14
29218045-8	2017	Our data indicate FH C-terminal domains are key for regulating PGA formation, thus increased FH protection may have a beneficial impact on diseases characterized by increased PGA formation, such as cardiovascular disease.	Folic Acid	63-66	complement factor H	Homo sapiens	18-20
29218045-8	2017	Our data indicate FH C-terminal domains are key for regulating PGA formation, thus increased FH protection may have a beneficial impact on diseases characterized by increased PGA formation, such as cardiovascular disease.	Folic Acid	175-178	complement factor H	Homo sapiens	18-20
29218045-8	2017	Our data indicate FH C-terminal domains are key for regulating PGA formation, thus increased FH protection may have a beneficial impact on diseases characterized by increased PGA formation, such as cardiovascular disease.	Folic Acid	175-178	complement factor H	Homo sapiens	93-95
29218045-9	2017	Additionally, aHUS-related mutations in domains 19-20 have varying effects on control of TRAP-mediated PGA formation, suggesting that some, but not all, aHUS-related mutations may cause increased PGA formation that contributes to excessive thrombosis in patients with aHUS.	Folic Acid	103-106	TRAP	Homo sapiens	89-93
29218045-9	2017	Additionally, aHUS-related mutations in domains 19-20 have varying effects on control of TRAP-mediated PGA formation, suggesting that some, but not all, aHUS-related mutations may cause increased PGA formation that contributes to excessive thrombosis in patients with aHUS.	Folic Acid	196-199	TRAP	Homo sapiens	89-93
29209581-7	2017	MTHFR A1298C is implicated in irregular homocysteine metabolism and aberrant folate cycles and, through this, it may play a role as either a driver in the development of MDD or as a predictive or diagnostic marker, possibly in combination with C677T.	Folic Acid	77-83	methylenetetrahydrofolate reductase	Homo sapiens	0-5
29062171-1	2017	Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme of folate pathway.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
29132841-6	2017	Pg-3-glc and PGA at 0.08 mumol/L increased the concentration of IL-10 (P&lt;.01 and P&lt;.001, respectively), but there was no effect on tumor necrosis factor-alpha, IL-1beta, IL-6, and IL-8, and there were no effects of the other compounds.	Folic Acid	13-16	interleukin 10	Homo sapiens	64-69
29132841-8	2017	Pg-3-glc and PGA, at physiologically relevant concentrations, had anti-inflammatory properties; however, effects were modest, only observed at the lowest dose tested and limited to IL-10.	Folic Acid	13-16	interleukin 10	Homo sapiens	181-186
28598562-5	2017	Serum folate and total Hcy (tHcy) levels are influenced by folate intake and genetic polymorphisms in 5,10-methylenetertahydrofolate reductase (MTHFR) such as C677T.	Folic Acid	6-12	methylenetetrahydrofolate reductase	Homo sapiens	144-149
28598562-10	2017	Accordingly, in this review, we discuss the effects of MTHFR C677T polymorphisms on serum tHcy and folate levels with folic acid intervention and evaluate approaches for overcoming folic acid deficiency and related symptoms.	Folic Acid	99-105	methylenetetrahydrofolate reductase	Homo sapiens	55-60
28598562-10	2017	Accordingly, in this review, we discuss the effects of MTHFR C677T polymorphisms on serum tHcy and folate levels with folic acid intervention and evaluate approaches for overcoming folic acid deficiency and related symptoms.	Folic Acid	118-128	methylenetetrahydrofolate reductase	Homo sapiens	55-60
30499755-0	2017	DNA Methylation Changes in Whole Blood and CD16+ Neutrophils in Response to Chronic Folic Acid Supplementation in Women of Childbearing Age.	Folic Acid	84-94	Fc gamma receptor IIIa	Homo sapiens	43-47
30499755-3	2017	The objective of this study was to determine if CD16+ neutrophils may provide more specific data than whole blood for identifying DNA methylation response to chronic folic acid supplementation.	Folic Acid	166-176	Fc gamma receptor IIIa	Homo sapiens	48-52
30499755-9	2017	These results suggest that the genome-wide DNA methylation response to chronic folic acid supplementation is different between whole blood and CD16+ neutrophils and that a single white blood cell type may function as a more specific epigenetic reporter of folate status than whole blood.	Folic Acid	79-89	Fc gamma receptor IIIa	Homo sapiens	143-147
28230279-0	2017	Folate Protects Hepatocytes of Hyperhomocysteinemia Mice From Apoptosis via Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)-Activated Endoplasmic Reticulum Stress.	Folic Acid	0-6	cystic fibrosis transmembrane conductance regulator	Mus musculus	76-127
28230279-0	2017	Folate Protects Hepatocytes of Hyperhomocysteinemia Mice From Apoptosis via Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)-Activated Endoplasmic Reticulum Stress.	Folic Acid	0-6	cystic fibrosis transmembrane conductance regulator	Mus musculus	129-133
28230279-4	2017	Mechanistically, folate inhibited homocysteine-induced CFTR promoter methylation and H3K27me3, which resulted in upregulation of CFTR expression, and reduced ER stress and liver cell apoptosis.	Folic Acid	17-23	cystic fibrosis transmembrane conductance regulator	Mus musculus	55-59
28230279-4	2017	Mechanistically, folate inhibited homocysteine-induced CFTR promoter methylation and H3K27me3, which resulted in upregulation of CFTR expression, and reduced ER stress and liver cell apoptosis.	Folic Acid	17-23	cystic fibrosis transmembrane conductance regulator	Mus musculus	129-133
28230279-5	2017	Further study showed that folate inhibited the expression of DNA methyltransferase 1 and enhancer of zeste homolog 2, downregulated the cellular concentrations of S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) and upregulated the SAM/SAH ratio, leading to the inhibition of Hcy-induced DNA hypermethylation and H3K27me3 in CFTR promoter.	Folic Acid	26-32	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	61-116
28230279-5	2017	Further study showed that folate inhibited the expression of DNA methyltransferase 1 and enhancer of zeste homolog 2, downregulated the cellular concentrations of S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) and upregulated the SAM/SAH ratio, leading to the inhibition of Hcy-induced DNA hypermethylation and H3K27me3 in CFTR promoter.	Folic Acid	26-32	cystic fibrosis transmembrane conductance regulator	Mus musculus	336-340
28230279-6	2017	In conclusion, our results provide insight into the protective role of folate in homocysteine-induced ER stress and liver cell apoptosis through the regulation of CFTR expression.	Folic Acid	71-77	cystic fibrosis transmembrane conductance regulator	Mus musculus	163-167
28230279-14	2017	Folate inhibits Hcy-induced ER stress via upregulation of CFTR expression in hepatocytes.	Folic Acid	0-6	cystic fibrosis transmembrane conductance regulator	Mus musculus	58-62
28230279-15	2017	Folate inhibits Hcy-induced methylation of CFTR promotor and H3K27me3.	Folic Acid	0-6	cystic fibrosis transmembrane conductance regulator	Mus musculus	43-47
28689805-0	2017	The importance of folate, vitamins B6 and B12 for the lowering of homocysteine concentrations for patients with recurrent pregnancy loss and MTHFR mutations.	Folic Acid	18-24	methylenetetrahydrofolate reductase	Homo sapiens	141-146
28440964-1	2017	The methylenetetrahydrofolate reductase (MTHFR) gene codes a crucial enzyme which involve in folate metabolism.	Folic Acid	23-29	methylenetetrahydrofolate reductase	Homo sapiens	41-46
28440964-9	2017	Also, we observed critical effect of vitamin B9 and B12 intake on decreasing of total homocysteine and improving of semen parameters among the men with T allele of MTHFR C677T polymorphism.	Folic Acid	37-47	methylenetetrahydrofolate reductase	Homo sapiens	164-169
27774577-2	2017	Folate is a methyl donor during DNA methylation, as it provides substrate for methylenetetrahydrofolate reductase (MTHFR) to convert 5,10-MTHF to 5-MTHF and subsequently metabolizes it to methionine.	Folic Acid	0-6	methylenetetrahydrofolate reductase	Homo sapiens	115-120
28811683-1	2017	Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme of folate pathway and required for DNA synthesis and methylation.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
27620989-5	2017	In vivo, kidney expression levels of NFkappaB2 p100 and p52 increased rapidly after folic acid injection, as did DNA binding of RelB and NFkappaB2, detected in nuclei isolated from the kidneys.	Folic Acid	84-94	nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100	Mus musculus	37-46
27620989-5	2017	In vivo, kidney expression levels of NFkappaB2 p100 and p52 increased rapidly after folic acid injection, as did DNA binding of RelB and NFkappaB2, detected in nuclei isolated from the kidneys.	Folic Acid	84-94	nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100	Mus musculus	56-59
27620989-6	2017	Compared with wild-type mice, MAP3K14 activity-deficient aly/aly (MAP3K14aly/aly) mice had less kidney dysfunction, inflammation, and apoptosis in acute folate nephropathy and less kidney dysfunction and a lower mortality rate in cisplatin-induced AKI.	Folic Acid	153-159	mitogen-activated protein kinase kinase kinase 14	Mus musculus	30-64
27620989-6	2017	Compared with wild-type mice, MAP3K14 activity-deficient aly/aly (MAP3K14aly/aly) mice had less kidney dysfunction, inflammation, and apoptosis in acute folate nephropathy and less kidney dysfunction and a lower mortality rate in cisplatin-induced AKI.	Folic Acid	153-159	mitogen-activated protein kinase kinase kinase 14	Mus musculus	57-60
28094233-2	2017	In this study, the combined effects of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and folate and vitamin B12 deficiency on serum total Hcy (tHcy) levels were evaluated in a healthy Chinese population in Yunnan Province, China.	Folic Acid	58-64	methylenetetrahydrofolate reductase	Homo sapiens	76-81
28094233-13	2017	Thus, folic acid and vitamin B12 supplementation could help prevent diseases associated with tHcy accumulation, especially in individuals with the MTHFR 677TT genotype.	Folic Acid	6-16	methylenetetrahydrofolate reductase	Homo sapiens	147-152
27759072-8	2017	In contrast, high folate concentrations attenuated the effects of the MTHFR C677T genotype on serum Hcy concentrations (P-value for interaction &lt;0.001).	Folic Acid	18-24	methylenetetrahydrofolate reductase	Homo sapiens	70-75
27759072-9	2017	Also, among males, blood folate concentration was the only lifestyle variable able to modify the influence of MTHFR A1298C genotypes on Hcy concentrations (P-value for the interaction &lt;0.001).	Folic Acid	25-31	methylenetetrahydrofolate reductase	Homo sapiens	110-115
27759072-11	2017	CONCLUSIONS: In summary, our study demonstrates a sex difference in Hcy concentrations among Brazilian young adults regarding MTHFR C677T-lifestyle interactions that are worsened under conditions of low blood folate.	Folic Acid	209-215	methylenetetrahydrofolate reductase	Homo sapiens	126-131
28138253-1	2017	Methylenetetrahydrofolate reductase (MTHFR) is a central enzyme involved in folate metabolism and plays an important role in DNA synthesis and methylation.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
28045076-0	2017	PHF14: an innate inhibitor against the progression of renal fibrosis following folic acid-induced kidney injury.	Folic Acid	79-89	PHD finger protein 14	Mus musculus	0-5
28045076-4	2017	By studying the chronic kidney injury mouse model, we found that PHF14 was upregulated in fibrotic kidneys after renal insults induced by folic acid administration.	Folic Acid	138-148	PHD finger protein 14	Mus musculus	65-70
27837682-3	2017	First, a noncytotoxic cancer-targeting polymersome is synthesized based on a biodegradable diblock copolymer, folic acid-poly(l-glutamic acid)-block-poly(epsilon-caprolactone) [FA-PGA-b-PCL].	Folic Acid	110-120	PHD finger protein 1	Homo sapiens	186-189
28685147-2	2017	The MTHFR enzyme acts in the folate metabolism, which is essential in methylation and synthesis of nucleic acids.	Folic Acid	29-35	methylenetetrahydrofolate reductase	Homo sapiens	4-9
28685147-3	2017	MTHFR C677T alters homocysteine levels and folate assimilation associated with DNA damage.	Folic Acid	43-49	methylenetetrahydrofolate reductase	Homo sapiens	0-5
28929692-8	2016	It was speculated that the mechanism of bovine serum albumin-induced allergic reactions may involve biosynthesis of isoflavone and folic acid and metabolism of tryptophan, nicotinic acid and nicotinamide.	Folic Acid	131-141	albumin	Rattus norvegicus	47-60
27760199-1	2016	The methylfolate trap, a metabolic blockage associated with anemia, neural tube defects, Alzheimer"s dementia, cardiovascular diseases, and cancer, was discovered in the 1960s, linking the metabolism of folate, vitamin B12, methionine and homocysteine.	Folic Acid	10-16	TRAP	Homo sapiens	17-21
27760199-3	2016	Here we identify the methylfolate trap as a novel determinant of the bacterial intrinsic death by sulfonamides, antibiotics that block de novo folate synthesis.	Folic Acid	27-33	TRAP	Homo sapiens	34-38
27130656-1	2016	The 5, 10 methylenetetrahydrofolate reductase (MTHFR) enzyme is a catalyst in the folate metabolism pathway, the byproducts of which are involved in the remethylation of homocysteine to methionine.	Folic Acid	29-35	methylenetetrahydrofolate reductase	Homo sapiens	47-52
27387868-1	2016	OBJECTIVE: The functional variant within the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene c.677C&gt;T, producing alterations in folate metabolism, has been associated with the risk of non-syndromic cleft lip with or without cleft palate (NSCL/P).	Folic Acid	69-75	methylenetetrahydrofolate reductase	Homo sapiens	87-92
27782649-14	2016	For paramagnetic Cu- and Mn-borate glasses, N4 was determined from the IR spectra after deducing the relative absorption coefficient of boron tetrahedral versus boron trigonal units, alpha = alpha4/alpha3, using NMR literature data of the diamagnetic glasses.	Folic Acid	44-46	immunoglobulin binding protein 1	Homo sapiens	191-204
27257051-1	2016	BACKGROUND: Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is the key enzyme in the transformation of folic acid metabolites.	Folic Acid	106-116	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	Homo sapiens	12-53
27257051-1	2016	BACKGROUND: Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is the key enzyme in the transformation of folic acid metabolites.	Folic Acid	106-116	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	Homo sapiens	55-61
27904604-0	2016	Evaluating the role of maternal folic acid supplementation in modifying the effects of methylenetetrahydrofolate reductase (C677T and A1298C) gene polymorphisms in oral cleft children.	Folic Acid	32-42	methylenetetrahydrofolate reductase	Homo sapiens	87-122
27904604-1	2016	BACKGROUND: We studied the role of maternal folic acid supplementation in modifying the effects of methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) gene polymorphisms in Iranian children with oral clefts.	Folic Acid	44-54	methylenetetrahydrofolate reductase	Homo sapiens	99-134
27904604-1	2016	BACKGROUND: We studied the role of maternal folic acid supplementation in modifying the effects of methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) gene polymorphisms in Iranian children with oral clefts.	Folic Acid	44-54	methylenetetrahydrofolate reductase	Homo sapiens	136-141
27478487-4	2016	The methylenetetrahydrofolate reductase (MTHFR) gene encodes for a 5-methylenetetrahydrofolate reductase involved in folate metabolism and neurotransmitter synthesis.	Folic Acid	23-29	methylenetetrahydrofolate reductase	Homo sapiens	41-46
27478487-4	2016	The methylenetetrahydrofolate reductase (MTHFR) gene encodes for a 5-methylenetetrahydrofolate reductase involved in folate metabolism and neurotransmitter synthesis.	Folic Acid	23-29	methylenetetrahydrofolate reductase	Homo sapiens	69-104
27183616-3	2016	In this study, we have defined complement-mediated mechanisms that enhance PGA formation in human whole blood stimulated with thrombin receptor-activating peptide (TRAP) using ex vivo flow cytometry assays.	Folic Acid	75-78	TRAP	Homo sapiens	126-162
27183616-3	2016	In this study, we have defined complement-mediated mechanisms that enhance PGA formation in human whole blood stimulated with thrombin receptor-activating peptide (TRAP) using ex vivo flow cytometry assays.	Folic Acid	75-78	TRAP	Homo sapiens	164-168
27183616-4	2016	We demonstrate that physiological properdin, a positive regulator of complement alternative pathway activity, increases PGA formation when added to TRAP-stimulated blood.	Folic Acid	120-123	TRAP	Homo sapiens	148-152
27183616-6	2016	Inhibition of endogenous properdin, either circulating in the blood or produced locally by leukocytes, impairs TRAP-mediated PGA formation to the same level as specific inhibition of either the alternative or classical pathway.	Folic Acid	125-128	TRAP	Homo sapiens	111-115
27183616-9	2016	Finally, we demonstrate that the effects of properdin on PGA formation are tightly regulated by Factor H.	Folic Acid	57-60	complement factor H	Homo sapiens	96-104
27001897-11	2016	CONCLUSION: The SNPs rs2797840 and rs2073817 in SARDH may serve as an indicator for the occurrence of NTDs in the Chinese Han population, and rs2797840 may also be an indicator for folate content of brain.	Folic Acid	181-187	sarcosine dehydrogenase	Homo sapiens	48-53
26317691-5	2016	In contrast, the DQB1*02 allele was more prevalent in PGA patients with Graves" disease (PGA-GD) vs. those with monoglandular GD (pc=0.002).	Folic Acid	54-57	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	17-21
26561410-0	2016	Common Polymorphisms That Affect Folate Transport or Metabolism Modify the Effect of the MTHFR 677C &gt; T Polymorphism on Folate Status.	Folic Acid	33-39	methylenetetrahydrofolate reductase	Homo sapiens	89-94
26561410-0	2016	Common Polymorphisms That Affect Folate Transport or Metabolism Modify the Effect of the MTHFR 677C &gt; T Polymorphism on Folate Status.	Folic Acid	123-129	methylenetetrahydrofolate reductase	Homo sapiens	89-94
26561410-10	2016	CONCLUSIONS: Folate status was lower in the MTHFR 677TT and SLC19A1 80AA genotypes compared with corresponding reference genotypes.	Folic Acid	13-19	methylenetetrahydrofolate reductase	Homo sapiens	44-49
26987498-3	2016	In the present study, the aim was to evaluate MTHFR C677T and A1298C polymorphisms that play a role on folate metabolism in PE patients.	Folic Acid	103-109	methylenetetrahydrofolate reductase	Homo sapiens	46-51
27614738-3	2016	MTHFR is a key enzyme that regulates the folate metabolism which has an important role in DNA synthesis, repair, and methylation.	Folic Acid	41-47	methylenetetrahydrofolate reductase	Homo sapiens	0-5
27213086-1	2016	Structural basis for exploration into MDM2 and MDM2-DHFR interaction plays a vital role in analyzing the obstruction in folate metabolism, nonsynthesis of purines, and further epigenetic regulation in Homo sapiens.	Folic Acid	120-126	MDM2 proto-oncogene	Homo sapiens	38-42
27213086-1	2016	Structural basis for exploration into MDM2 and MDM2-DHFR interaction plays a vital role in analyzing the obstruction in folate metabolism, nonsynthesis of purines, and further epigenetic regulation in Homo sapiens.	Folic Acid	120-126	MDM2 proto-oncogene	Homo sapiens	47-51
26564107-1	2015	Methylenetetrahydrofolate reductase (MTHFR) plays a key role in folate metabolism, and folate is implicated in carcinogenesis due to its role in DNA methylation, repair and synthesis.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
26564107-1	2015	Methylenetetrahydrofolate reductase (MTHFR) plays a key role in folate metabolism, and folate is implicated in carcinogenesis due to its role in DNA methylation, repair and synthesis.	Folic Acid	64-70	methylenetetrahydrofolate reductase	Homo sapiens	0-35
26564107-1	2015	Methylenetetrahydrofolate reductase (MTHFR) plays a key role in folate metabolism, and folate is implicated in carcinogenesis due to its role in DNA methylation, repair and synthesis.	Folic Acid	64-70	methylenetetrahydrofolate reductase	Homo sapiens	37-42
26307085-0	2015	High-dose folic acid supplementation alters the human sperm methylome and is influenced by the MTHFR C677T polymorphism.	Folic Acid	10-20	methylenetetrahydrofolate reductase	Homo sapiens	95-100
26307085-7	2015	The most marked loss of DNA methylation was found in sperm from patients homozygous for the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, a common polymorphism in a key enzyme required for folate metabolism.	Folic Acid	111-117	methylenetetrahydrofolate reductase	Homo sapiens	129-134
26307085-10	2015	Our data reveal alterations of the human sperm epigenome associated with high-dose folic acid supplementation, effects that were exacerbated by a common polymorphism in MTHFR.	Folic Acid	83-93	methylenetetrahydrofolate reductase	Homo sapiens	169-174
26537450-0	2015	Folic acid protects against arsenic-mediated embryo toxicity by up-regulating the expression of Dvr1.	Folic Acid	0-10	growth differentiation factor 3	Danio rerio	96-100
26537450-5	2015	Both real-time PCR analysis and whole in-mount hybridization showed that folic acid significantly rescued the decrease in Dvr1 expression caused by arsenite.	Folic Acid	73-83	growth differentiation factor 3	Danio rerio	122-126
26537450-9	2015	Our data demonstrated that folic acid supplementation protected against arsenic-mediated embryo toxicity by up-regulating the expression of Dvr1/GDF1, and folic acid enhanced the expression of GDF1 by decreasing p66Shc expression and subcellular ROS levels.	Folic Acid	27-37	growth differentiation factor 3	Danio rerio	140-144
26333700-2	2015	This study was conducted to investigate whether indirect or direct exposure to folate and impaired folate metabolism, reflected as methylene-tetrahydrofolate reductase (MTHFR) C677T polymorphism, would contribute to the development of asthma and other allergic diseases.	Folic Acid	79-85	methylenetetrahydrofolate reductase	Homo sapiens	131-167
26333700-2	2015	This study was conducted to investigate whether indirect or direct exposure to folate and impaired folate metabolism, reflected as methylene-tetrahydrofolate reductase (MTHFR) C677T polymorphism, would contribute to the development of asthma and other allergic diseases.	Folic Acid	79-85	methylenetetrahydrofolate reductase	Homo sapiens	169-174
26333700-2	2015	This study was conducted to investigate whether indirect or direct exposure to folate and impaired folate metabolism, reflected as methylene-tetrahydrofolate reductase (MTHFR) C677T polymorphism, would contribute to the development of asthma and other allergic diseases.	Folic Acid	99-105	methylenetetrahydrofolate reductase	Homo sapiens	131-167
26333700-2	2015	This study was conducted to investigate whether indirect or direct exposure to folate and impaired folate metabolism, reflected as methylene-tetrahydrofolate reductase (MTHFR) C677T polymorphism, would contribute to the development of asthma and other allergic diseases.	Folic Acid	99-105	methylenetetrahydrofolate reductase	Homo sapiens	169-174
26333700-9	2015	CONCLUSIONS: It is indicated that maternal folic acid supplementation during early pregnancy may increase the risk of wheeze in early childhood and that the TT genotype of MTHFR C677T polymorphism impairing folic acid metabolism would be at high risk of asthma development.	Folic Acid	43-53	methylenetetrahydrofolate reductase	Homo sapiens	172-177
26333700-9	2015	CONCLUSIONS: It is indicated that maternal folic acid supplementation during early pregnancy may increase the risk of wheeze in early childhood and that the TT genotype of MTHFR C677T polymorphism impairing folic acid metabolism would be at high risk of asthma development.	Folic Acid	207-217	methylenetetrahydrofolate reductase	Homo sapiens	172-177
26282096-4	2015	Furthermore, The PEG layer would detach from the NPs due to the up-regulated extracellular MMP2 and MMP9 in tumors, resulting in the exposure of folate to enhance the cellular internalization via folate receptor mediated endocytosis, which accelerated the release rate of CPT in vivo.	Folic Acid	145-151	matrix metallopeptidase 2	Mus musculus	91-95
26535623-1	2015	The C677T and A1298C polymorphisms in methylene-tetrahydrofolate reductase (MTHFR), which regulates the release of active folate in the body, may have reduced activity.	Folic Acid	58-64	methylenetetrahydrofolate reductase	Homo sapiens	76-81
26629414-1	2015	The methylenetetrahydrofolate reductase (MTHFR) gene codes for the MTHFR enzyme which plays a key role in the pathway of folate and methionine metabolism.	Folic Acid	23-29	methylenetetrahydrofolate reductase	Homo sapiens	41-46
26629414-1	2015	The methylenetetrahydrofolate reductase (MTHFR) gene codes for the MTHFR enzyme which plays a key role in the pathway of folate and methionine metabolism.	Folic Acid	23-29	methylenetetrahydrofolate reductase	Homo sapiens	67-72
26492244-6	2015	The results showed that folic acid stimulated DNMT gene and protein expression, and DNMT activity.	Folic Acid	24-34	DNA methyltransferase 1	Homo sapiens	46-50
26492244-8	2015	The results indicate that folic acid induces methylation potential-dependent DNMT enzymes, thereby attenuating Abeta production.	Folic Acid	26-36	DNA methyltransferase 1	Homo sapiens	77-81
26467879-2	2015	The MTHFR C677T gene decreases the bioavailability of folate and increases plasma homocysteine, a risk factor for thrombosis.	Folic Acid	54-60	methylenetetrahydrofolate reductase	Homo sapiens	4-9
26192119-4	2015	MALDI-TOF MS fingerprinting revealed that this MNSFbeta adduct consists of an 8.5 kDa MNSFbeta and 10-formyltetrahydrofolate dehydrogenase (FDH), an abundant enzyme of folate metabolism.	Folic Acid	118-124	aldehyde dehydrogenase 1 family, member L1	Mus musculus	140-143
26266420-6	2015	However, the MTHFR A1298C mutation may confer protection by elevating the serum folate level (p = 0.025).	Folic Acid	80-86	methylenetetrahydrofolate reductase	Homo sapiens	13-18
26247969-10	2015	In addition, the serum levels of P4, E2, LH, and PRL were reduced in folate-deficient mice, and the expression of progesterone receptor (PR) and estrogen receptor alpha (ERalpha) were abnormal.	Folic Acid	69-75	prolactin	Mus musculus	49-52
26247969-10	2015	In addition, the serum levels of P4, E2, LH, and PRL were reduced in folate-deficient mice, and the expression of progesterone receptor (PR) and estrogen receptor alpha (ERalpha) were abnormal.	Folic Acid	69-75	progesterone receptor	Mus musculus	49-51
25805039-0	2015	Association of folate and other one-carbon related nutrients with hypermethylation status and expression of RARB, BRCA1, and RASSF1A genes in breast cancer patients.	Folic Acid	15-21	BRCA1 DNA repair associated	Homo sapiens	114-119
25805039-0	2015	Association of folate and other one-carbon related nutrients with hypermethylation status and expression of RARB, BRCA1, and RASSF1A genes in breast cancer patients.	Folic Acid	15-21	Ras association domain family member 1	Homo sapiens	125-132
25805039-7	2015	The crude dietary folate and adjusted cobalamin intakes were inversely associated with methylated RARB and BRCA1.	Folic Acid	18-24	BRCA1 DNA repair associated	Homo sapiens	107-112
25805039-11	2015	Although high folate intake increased the chance of unmethylation-dependent overexpression of BRCA1 3-fold, cobalamin and methionine were inversely linked to methylation-mediated expression.	Folic Acid	14-20	BRCA1 DNA repair associated	Homo sapiens	94-99
25805039-15	2015	Dietary folate and cobalamin intake is inversely associated with methylated RARB and BRCA1.	Folic Acid	8-14	BRCA1 DNA repair associated	Homo sapiens	85-90
26086354-0	2015	Photoinactivation of tyrosinase sensitized by folic acid photoproducts.	Folic Acid	46-56	tyrosinase	Homo sapiens	21-31
26086354-4	2015	Aqueous solutions of tyrosinase were exposed to UV-A irradiation (350nm) in the presence of PteGlu and its photoproducts (6-formylpterin and 6-carboxypterin).	Folic Acid	92-98	tyrosinase	Homo sapiens	21-31
26086354-6	2015	In this work, we present data that demonstrate unequivocally that solutions of tyrosinase exposed to UV-A irradiation in the presence of PteGlu, undergo enzyme inactivation.	Folic Acid	137-143	tyrosinase	Homo sapiens	79-89
26086354-9	2015	The tyrosinase inactivation involves two different pathways: (i) a photosensitization process and (ii) the oxidation of the enzyme by the hydrogen peroxide produced during the photooxidation of PteGlu and its photoproduct.	Folic Acid	194-200	tyrosinase	Homo sapiens	4-14
26186555-1	2015	BACKGROUND: 5,10-Methylenetetrahydrofolate reductase (MTHFR) plays a central role in folate metabolism by irreversibly converting 5,10-methylenetetrahydrofolate to 5-methylenetetrahydrofolate, a predominant circulating form of folate.	Folic Acid	36-42	methylenetetrahydrofolate reductase	Capra hircus	54-59
26186555-1	2015	BACKGROUND: 5,10-Methylenetetrahydrofolate reductase (MTHFR) plays a central role in folate metabolism by irreversibly converting 5,10-methylenetetrahydrofolate to 5-methylenetetrahydrofolate, a predominant circulating form of folate.	Folic Acid	85-91	methylenetetrahydrofolate reductase	Capra hircus	12-52
26186555-1	2015	BACKGROUND: 5,10-Methylenetetrahydrofolate reductase (MTHFR) plays a central role in folate metabolism by irreversibly converting 5,10-methylenetetrahydrofolate to 5-methylenetetrahydrofolate, a predominant circulating form of folate.	Folic Acid	85-91	methylenetetrahydrofolate reductase	Capra hircus	54-59
26186555-2	2015	Folate is reportedly important for milk protein synthesis, and MTHFR may be a key regulatory point of folate metabolism for milk protein synthesis in mammary epithelial cells.	Folic Acid	102-108	methylenetetrahydrofolate reductase	Capra hircus	63-68
25841988-1	2015	Genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) were considered to have some influence on both folate metabolism and cancer risk.	Folic Acid	44-50	methylenetetrahydrofolate reductase	Homo sapiens	62-67
25544674-3	2015	We conducted a case-control study to explore polymorphisms of the major folate pathway genes, including methylenetetrahydrofolate reductase (MTHFR) 677C&gt;T, MTHFR 1298A&gt;C, methionine synthase (MTR) 2756A&gt;G, methionine synthase reductase (MTRR) 66A&gt;G and reduced folate carrier 1 (RFC-1) 80A&gt;G, and their associations with URPL.	Folic Acid	72-78	methylenetetrahydrofolate reductase	Homo sapiens	104-139
25544674-3	2015	We conducted a case-control study to explore polymorphisms of the major folate pathway genes, including methylenetetrahydrofolate reductase (MTHFR) 677C&gt;T, MTHFR 1298A&gt;C, methionine synthase (MTR) 2756A&gt;G, methionine synthase reductase (MTRR) 66A&gt;G and reduced folate carrier 1 (RFC-1) 80A&gt;G, and their associations with URPL.	Folic Acid	72-78	methylenetetrahydrofolate reductase	Homo sapiens	141-146
25544674-3	2015	We conducted a case-control study to explore polymorphisms of the major folate pathway genes, including methylenetetrahydrofolate reductase (MTHFR) 677C&gt;T, MTHFR 1298A&gt;C, methionine synthase (MTR) 2756A&gt;G, methionine synthase reductase (MTRR) 66A&gt;G and reduced folate carrier 1 (RFC-1) 80A&gt;G, and their associations with URPL.	Folic Acid	72-78	methylenetetrahydrofolate reductase	Homo sapiens	159-164
25544674-3	2015	We conducted a case-control study to explore polymorphisms of the major folate pathway genes, including methylenetetrahydrofolate reductase (MTHFR) 677C&gt;T, MTHFR 1298A&gt;C, methionine synthase (MTR) 2756A&gt;G, methionine synthase reductase (MTRR) 66A&gt;G and reduced folate carrier 1 (RFC-1) 80A&gt;G, and their associations with URPL.	Folic Acid	72-78	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	177-196
25544674-3	2015	We conducted a case-control study to explore polymorphisms of the major folate pathway genes, including methylenetetrahydrofolate reductase (MTHFR) 677C&gt;T, MTHFR 1298A&gt;C, methionine synthase (MTR) 2756A&gt;G, methionine synthase reductase (MTRR) 66A&gt;G and reduced folate carrier 1 (RFC-1) 80A&gt;G, and their associations with URPL.	Folic Acid	123-129	methylenetetrahydrofolate reductase	Homo sapiens	141-146
26046315-7	2015	Of the potentially susceptible polymorphisms, MTHFR 2572C&gt;A was associated with increased homocysteine and decreased folate levels in the plasma based on MTHFR 677CC.	Folic Acid	120-126	methylenetetrahydrofolate reductase	Homo sapiens	46-51
26046315-7	2015	Of the potentially susceptible polymorphisms, MTHFR 2572C&gt;A was associated with increased homocysteine and decreased folate levels in the plasma based on MTHFR 677CC.	Folic Acid	120-126	methylenetetrahydrofolate reductase	Homo sapiens	157-162
25788000-0	2015	Assessing the association between the methylenetetrahydrofolate reductase (MTHFR) 677C&gt;T polymorphism and blood folate concentrations: a systematic review and meta-analysis of trials and observational studies.	Folic Acid	57-63	methylenetetrahydrofolate reductase	Homo sapiens	75-80
25788000-3	2015	OBJECTIVE: We assessed the association between MTHFR C677T genotypes and blood folate concentrations among healthy women aged 12-49 y.	Folic Acid	79-85	methylenetetrahydrofolate reductase	Homo sapiens	47-52
25788000-11	2015	CONCLUSIONS: Meta-analysis results (limited to the MA, the recommended population assessment method) indicated a consistent percentage difference in S/P and RBC folate concentrations across MTHFR C677T genotypes.	Folic Acid	161-167	methylenetetrahydrofolate reductase	Homo sapiens	190-195
25960189-0	2015	Folic acid supplementation in vitro induces cell type-specific changes in BRCA1 and BRCA 2 mRNA expression, but does not alter DNA methylation of their promoters or DNA repair.	Folic Acid	0-10	BRCA1 DNA repair associated	Homo sapiens	74-79
25960189-0	2015	Folic acid supplementation in vitro induces cell type-specific changes in BRCA1 and BRCA 2 mRNA expression, but does not alter DNA methylation of their promoters or DNA repair.	Folic Acid	0-10	BRCA2 DNA repair associated	Homo sapiens	84-90
25960189-7	2015	Folic acid induced increased BRCA1 protein expression in Hs578T, but not HepG2 cells, whereas BRCA2 protein levels were undetectable.	Folic Acid	0-10	BRCA1 DNA repair associated	Homo sapiens	29-34
25985325-8	2015	As well, MTHFR C677T, A1298C and G1793A polymorphisms were related to elevated serum level of Hcy, and folate and vitamin B12 deficiency.	Folic Acid	103-109	methylenetetrahydrofolate reductase	Homo sapiens	9-14
25758536-8	2015	The baseline concentration of serum folate in subjects with polymorphism combination, reduced folate carrier protein, RFC1-80 GA and methylenetetrahydrofolate reductase, MTHFR677 CT+TT, was lower than RFC1-80 AA and MTHFR677 CT+TT (p = 0.002).	Folic Acid	36-42	methylenetetrahydrofolate reductase	Homo sapiens	133-168
25758536-8	2015	The baseline concentration of serum folate in subjects with polymorphism combination, reduced folate carrier protein, RFC1-80 GA and methylenetetrahydrofolate reductase, MTHFR677 CT+TT, was lower than RFC1-80 AA and MTHFR677 CT+TT (p = 0.002).	Folic Acid	36-42	replication factor C subunit 1	Homo sapiens	201-205
25758536-9	2015	After folic acid supplementation, a higher increase in the concentration of serum folate was detected in subjects with polymorphism combination RFC1-80 GA and MTHFR677 CC than RFC1-80 GG and MTHFR CT+TT combination (p &lt; 0.0001).	Folic Acid	6-16	replication factor C subunit 1	Homo sapiens	144-148
25758536-9	2015	After folic acid supplementation, a higher increase in the concentration of serum folate was detected in subjects with polymorphism combination RFC1-80 GA and MTHFR677 CC than RFC1-80 GG and MTHFR CT+TT combination (p &lt; 0.0001).	Folic Acid	6-16	replication factor C subunit 1	Homo sapiens	176-180
25758536-9	2015	After folic acid supplementation, a higher increase in the concentration of serum folate was detected in subjects with polymorphism combination RFC1-80 GA and MTHFR677 CC than RFC1-80 GG and MTHFR CT+TT combination (p &lt; 0.0001).	Folic Acid	6-16	methylenetetrahydrofolate reductase	Homo sapiens	159-164
25758536-9	2015	After folic acid supplementation, a higher increase in the concentration of serum folate was detected in subjects with polymorphism combination RFC1-80 GA and MTHFR677 CC than RFC1-80 GG and MTHFR CT+TT combination (p &lt; 0.0001).	Folic Acid	82-88	replication factor C subunit 1	Homo sapiens	144-148
25758536-9	2015	After folic acid supplementation, a higher increase in the concentration of serum folate was detected in subjects with polymorphism combination RFC1-80 GA and MTHFR677 CC than RFC1-80 GG and MTHFR CT+TT combination (p &lt; 0.0001).	Folic Acid	82-88	replication factor C subunit 1	Homo sapiens	176-180
25758536-9	2015	After folic acid supplementation, a higher increase in the concentration of serum folate was detected in subjects with polymorphism combination RFC1-80 GA and MTHFR677 CC than RFC1-80 GG and MTHFR CT+TT combination (p &lt; 0.0001).	Folic Acid	82-88	methylenetetrahydrofolate reductase	Homo sapiens	159-164
25758536-12	2015	The combination of RFC1-80 and MTHFR-677 polymorphisms had a profound affect on the concentration of serum folate in healthy subjects before and after folic acid supplementation.	Folic Acid	107-113	replication factor C subunit 1	Homo sapiens	19-23
25758536-12	2015	The combination of RFC1-80 and MTHFR-677 polymorphisms had a profound affect on the concentration of serum folate in healthy subjects before and after folic acid supplementation.	Folic Acid	107-113	methylenetetrahydrofolate reductase	Homo sapiens	31-36
25758536-12	2015	The combination of RFC1-80 and MTHFR-677 polymorphisms had a profound affect on the concentration of serum folate in healthy subjects before and after folic acid supplementation.	Folic Acid	151-161	replication factor C subunit 1	Homo sapiens	19-23
25758536-12	2015	The combination of RFC1-80 and MTHFR-677 polymorphisms had a profound affect on the concentration of serum folate in healthy subjects before and after folic acid supplementation.	Folic Acid	151-161	methylenetetrahydrofolate reductase	Homo sapiens	31-36
25758986-0	2015	Folate metabolism gene polymorphisms MTHFR C677T and A1298C and risk for preeclampsia: a meta-analysis.	Folic Acid	0-6	methylenetetrahydrofolate reductase	Homo sapiens	37-42
25774061-10	2015	TNC levels correlated moderately with disease activity: PGA r = 0.4, EMS r = 0.34, TJC r = 0.4, SJC r = 0.46, ESR r = 0.42, and CRP r = 0.32.	Folic Acid	56-59	tenascin C	Homo sapiens	0-3
26137281-7	2015	The MTHFR 677CT/1298AC and MTHFR 1298AC+CC/TSER 2R3R genotypes in the presence of plasma folate levels &lt;=4.12 ng/ml were associated with significantly increased CRC risk.	Folic Acid	89-95	methylenetetrahydrofolate reductase	Homo sapiens	4-9
26137281-7	2015	The MTHFR 677CT/1298AC and MTHFR 1298AC+CC/TSER 2R3R genotypes in the presence of plasma folate levels &lt;=4.12 ng/ml were associated with significantly increased CRC risk.	Folic Acid	89-95	methylenetetrahydrofolate reductase	Homo sapiens	27-32
26137281-9	2015	Therefore, the data suggest that i) MTHFR polymorphisms combined with low plasma folate levels and ii) polymorphisms in folate metabolism-related genes combined with metabolic syndrome risk factors (hypertension and DM) increase the odds of developing CRC.	Folic Acid	81-87	methylenetetrahydrofolate reductase	Homo sapiens	36-41
25728832-2	2015	The current study examined folate metabolism as a potential mechanism of CVD and neurocognitive deficits by: 1) using endothelial dysfunction as a biomarker of CVD, and 2) comparing enzymes associated with neurocognition, CVD, and critical to folate metabolism, methylenetetrahydrofolate reductase (MTHFR) and catechol-o-methyl transferase (COMT).	Folic Acid	27-33	methylenetetrahydrofolate reductase	Homo sapiens	262-297
25728832-2	2015	The current study examined folate metabolism as a potential mechanism of CVD and neurocognitive deficits by: 1) using endothelial dysfunction as a biomarker of CVD, and 2) comparing enzymes associated with neurocognition, CVD, and critical to folate metabolism, methylenetetrahydrofolate reductase (MTHFR) and catechol-o-methyl transferase (COMT).	Folic Acid	27-33	methylenetetrahydrofolate reductase	Homo sapiens	299-304
25754229-1	2015	INTRODUCTION: Our objective was to investigate the association between gene polymorphisms of folate cycle (MTHFR 677 C&gt;T, MTHFR 1298 A&gt;C, MTR 2756 A&gt;G, and MTRR 66 A&gt;G) and the risk of pulmonary embolism (PE) in a case-control study.	Folic Acid	93-99	methylenetetrahydrofolate reductase	Homo sapiens	107-112
25754229-1	2015	INTRODUCTION: Our objective was to investigate the association between gene polymorphisms of folate cycle (MTHFR 677 C&gt;T, MTHFR 1298 A&gt;C, MTR 2756 A&gt;G, and MTRR 66 A&gt;G) and the risk of pulmonary embolism (PE) in a case-control study.	Folic Acid	93-99	methylenetetrahydrofolate reductase	Homo sapiens	125-130
25566964-3	2015	Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme involved in folate metabolism and DNA synthesis.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
25566964-4	2015	This study aims to examine whether single nucleotide polymorphisms (SNP) in the MTHFR gene are associated with risk and survival of breast cancer and serum folate levels in healthy controls.	Folic Acid	156-162	methylenetetrahydrofolate reductase	Homo sapiens	80-85
25925782-6	2015	Folate deprivation upregulates K81 acetylation and destabilizes MAT IIalpha to moderate cell proliferation, whereas a single mutation at K81 reverses the proliferative disadvantage of cancer cells upon folate deprivation.	Folic Acid	0-6	keratin 81	Homo sapiens	31-34
25925782-6	2015	Folate deprivation upregulates K81 acetylation and destabilizes MAT IIalpha to moderate cell proliferation, whereas a single mutation at K81 reverses the proliferative disadvantage of cancer cells upon folate deprivation.	Folic Acid	202-208	keratin 81	Homo sapiens	137-140
25915064-10	2015	A positive correlation between serum folate levels and peripheral blood MTHFR amplicon methylation status was also observed (r = 0.25, p = 0.023).	Folic Acid	37-43	methylenetetrahydrofolate reductase	Homo sapiens	72-77
25966173-2	2015	The analysis of polymorphisms in the MTHFR gene has revealed associations with cancer; in particular the C677T polymorphism, which has been suggested to affect folate metabolism, DNA methylation, synthesis, and repair, and to contribute to tumor promotion in the mammary gland.	Folic Acid	160-166	methylenetetrahydrofolate reductase	Homo sapiens	37-42
25833982-2	2015	Serine hydroxymethyltransferase 1 (SHMT1) is an essential scaffold protein in folate-dependent de novo thymidylate synthesis in the nucleus.	Folic Acid	78-84	serine hydroxymethyltransferase 1 (soluble)	Mus musculus	0-33
25833982-2	2015	Serine hydroxymethyltransferase 1 (SHMT1) is an essential scaffold protein in folate-dependent de novo thymidylate synthesis in the nucleus.	Folic Acid	78-84	serine hydroxymethyltransferase 1 (soluble)	Mus musculus	35-40
25912570-11	2015	CONCLUSIONS: Folic acid may attenuate Dex-induced restriction on placental growth by elevating the expression of VEGFA and PIGF, and further raising vascular density.	Folic Acid	13-23	vascular endothelial growth factor A	Mus musculus	113-118
25912570-11	2015	CONCLUSIONS: Folic acid may attenuate Dex-induced restriction on placental growth by elevating the expression of VEGFA and PIGF, and further raising vascular density.	Folic Acid	13-23	phosphatidylinositol glycan anchor biosynthesis, class F	Mus musculus	123-127
25793274-3	2015	We hypothesized that maternal diets supplemented with folic acid (FA) during pregnancy modify the expression of placental HSD11B2 through gene methylation.	Folic Acid	54-64	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	122-129
25886278-11	2015	Pregnant women carrying the MTHFR 677TT genotype showed lower serum folate levels (p = 0.042) and higher Hcy levels (p = 0.003).	Folic Acid	68-74	methylenetetrahydrofolate reductase	Homo sapiens	28-33
24616290-8	2015	RESULTS: Serum folate levels during mid-pregnancy were inversely associated with CB eosinophil count (adjusted odds ratio [OR] 0.72, 95% confidence interval [CI], 0.54-0.96) and positively associated with CB interleukin-10 levels (1.47, 1.11-1.94).	Folic Acid	15-21	interleukin 10	Homo sapiens	208-222
25466229-1	2015	Evidence from observational studies suggests that there is an association among depression and brain-derived neurotrophic factor (BDNF), polyunsaturated fatty acids (PUFAs), and folate; however, this association has yet to be examined in childhood and adolescent depression.	Folic Acid	178-184	brain derived neurotrophic factor	Homo sapiens	95-128
25514347-5	2015	Both PEG and monovalent folate-PEG (PEG3.4k-FA1) modified PME were prepared as control polymers, which were named as PME-(PEG3.5k)1.69 and PME-(PEG3.4k-FA1)1.66, respectively.	Folic Acid	24-30	FA complementation group A	Homo sapiens	44-47
25559736-7	2015	One of the salient observations of this study was a coupled increase in the expression of renal, relA, NF-kB2, and p53 genes and proteins during folic acid induced AKI (FA AKI).	Folic Acid	145-155	nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100	Mus musculus	103-109
26610311-7	2015	The objective of this study was to select the optimal producing yeast strain by determining the differences in nucleotide sequences in the FOL2, FOL3 and DFR1 genes of folic acid biosynthesis pathway.	Folic Acid	168-178	dihydrofolate synthase	Saccharomyces cerevisiae S288C	145-149
25283235-1	2015	OBJECTIVE: To study folic acid intake, folate status and pregnancy outcome after infertility treatment in women with different infertility diagnoses in relation to methylenetetrahydrofolate reductase (MTHFR) 677C&gt;T, 1298A&gt;C and 1793G&gt;A polymorphisms.	Folic Acid	20-30	methylenetetrahydrofolate reductase	Homo sapiens	201-206
25107455-1	2015	Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme involved in folate metabolism, which is essential for DNA synthesis and methylation.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
25634728-0	2015	Individualized supplementation of folic acid according to polymorphisms of methylenetetrahydrofolate reductase (MTHFR), methionine synthase reductase (MTRR) reduced pregnant complications.	Folic Acid	34-44	methylenetetrahydrofolate reductase	Homo sapiens	75-110
25634728-0	2015	Individualized supplementation of folic acid according to polymorphisms of methylenetetrahydrofolate reductase (MTHFR), methionine synthase reductase (MTRR) reduced pregnant complications.	Folic Acid	34-44	methylenetetrahydrofolate reductase	Homo sapiens	112-117
25634728-1	2015	OBJECTIVE: This study aimed to detect the genotype distributions and allele frequencies of methylenetetrahydrofolate reductase (MTHFR) C677T, A1298C and methionine synthase reductase (MTRR) A66G polymorphisms of pregnant women in Jiaodong region in China, and to investigate whether folic acid supplementation affect the pregnancy complications.	Folic Acid	283-293	methylenetetrahydrofolate reductase	Homo sapiens	91-126
25634728-1	2015	OBJECTIVE: This study aimed to detect the genotype distributions and allele frequencies of methylenetetrahydrofolate reductase (MTHFR) C677T, A1298C and methionine synthase reductase (MTRR) A66G polymorphisms of pregnant women in Jiaodong region in China, and to investigate whether folic acid supplementation affect the pregnancy complications.	Folic Acid	283-293	methylenetetrahydrofolate reductase	Homo sapiens	128-133
26598833-0	2015	Regulation of Folate-Mediated One-Carbon Metabolism by Glycine N-Methyltransferase (GNMT) and Methylenetetrahydrofolate Reductase (MTHFR).	Folic Acid	14-20	methylenetetrahydrofolate reductase	Homo sapiens	94-129
26598833-0	2015	Regulation of Folate-Mediated One-Carbon Metabolism by Glycine N-Methyltransferase (GNMT) and Methylenetetrahydrofolate Reductase (MTHFR).	Folic Acid	14-20	methylenetetrahydrofolate reductase	Homo sapiens	131-136
26598833-5	2015	We discovered that the MTHFR TT genotype significantly reduces folate-dependent remethylation under folate restriction, but it assists purine synthesis when folate is adequate.	Folic Acid	63-69	methylenetetrahydrofolate reductase	Homo sapiens	23-28
26598833-5	2015	We discovered that the MTHFR TT genotype significantly reduces folate-dependent remethylation under folate restriction, but it assists purine synthesis when folate is adequate.	Folic Acid	100-106	methylenetetrahydrofolate reductase	Homo sapiens	23-28
26598833-5	2015	We discovered that the MTHFR TT genotype significantly reduces folate-dependent remethylation under folate restriction, but it assists purine synthesis when folate is adequate.	Folic Acid	100-106	methylenetetrahydrofolate reductase	Homo sapiens	23-28
27843994-2	2015	The MTHFR gene (OMIM: 607093) plays an important role in the folate metabolism.	Folic Acid	61-67	methylenetetrahydrofolate reductase	Homo sapiens	4-9
24597986-1	2014	Abstract Methotrexate (MTX) is a key component of chemotherapeutic regimens for childhood acute lymphoblastic leukemia (ALL), and enters the cell via active transport mediated by the reduced folate carrier (RFC1).	Folic Acid	191-197	replication factor C subunit 1	Homo sapiens	207-211
25341694-4	2014	The role of folic acid in carcinogenesis may be modulated by polymorphism C677T in MTHFR and tandem repeats 2R/3R in the promoter site of TYMS gene that are related to decreased enzymatic activity and quantity and availability of the enzyme, respectively.	Folic Acid	12-22	methylenetetrahydrofolate reductase	Homo sapiens	83-88
25217320-5	2014	The MTHFR 667 T allele and MTR 2756 G allele were associated with a higher risk of breast cancer in individuals with low folate intake, vitamin B6, and vitamin B12, but the association disappeared among subjects with moderate and high intake of folate, vitamin B6, and vitamin B12.	Folic Acid	121-127	methylenetetrahydrofolate reductase	Homo sapiens	4-9
25322900-4	2014	MTHFR 677T allele carriers with middle or low tertile plasma folate (&lt;14.7 nmol/L) had 8.2 % higher tHcy compared to the 677CC genotype (p &lt; 0.01).	Folic Acid	61-67	methylenetetrahydrofolate reductase	Homo sapiens	0-5
24458267-1	2014	PURPOSE: Meta-analyses have suggested an effect of MTHFR C677T genotype (rs1801133), a proxy for blood total homocysteine, on cardiovascular disease (CVD) in populations with low population dietary folate.	Folic Acid	198-204	methylenetetrahydrofolate reductase	Homo sapiens	51-56
24458267-2	2014	The aim was to examine the association and effect modification by serum folate and vitamin B12 levels between MTHFR and CVD-related outcomes in a general population with no mandatory folic acid fortification policy.	Folic Acid	72-78	methylenetetrahydrofolate reductase	Homo sapiens	110-115
25066213-4	2014	Thirteen variants in the pyrimidine metabolism genes, DPYD, DPYS, PPAT, and TYMS, also interacted significantly with folate in a multivariant analysis (corrected p = 9.9 x 10-6) but collectively explained only 0.2% of OC risk.	Folic Acid	117-123	dihydropyrimidine dehydrogenase	Homo sapiens	54-58
25066213-6	2014	CONCLUSION: Variation in pyrimidine metabolism genes, particularly DPYD, which was previously reported to be associated with OC, may influence risk; however, stratification by folate intake is unlikely to modify disease risk appreciably in these women.	Folic Acid	176-182	dihydropyrimidine dehydrogenase	Homo sapiens	67-71
24637499-2	2014	Methylenetetrahydrofolate reductase (MTHFR) activity may affect the sensitivity of patients to folate-based chemotherapeutic drugs, thus influencing the relapse risk.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
25278626-4	2014	In patients supplemented with 0.4 mg/d folic acid undergoing ovarian hyperstimulation and oocyte pick-up, carriers of the MTHFR 677T mutation were found to have lower serum estradiol concentrations at ovulation and fewer oocytes could be retrieved from them.	Folic Acid	39-49	methylenetetrahydrofolate reductase	Homo sapiens	122-127
25162227-2	2014	For example, deletion of human lymphoid nuclear protein related to AF4/AFF member 3 (LAF4/AFF3) is known to cause severe neurodevelopmental defects, and silencing of the gene is also associated with ID at the folate-sensitive fragile site (FSFS) FRA2A; yet the normal function of this gene in the nervous system is unclear.	Folic Acid	209-215	AF4/FMR2 family member 1	Homo sapiens	67-70
25146845-1	2014	Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme involved in folate metabolism and DNA synthesis.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
24817375-0	2014	A critical role of noggin in developing folate-nonresponsive NTD in Fkbp8 -/- embryos.	Folic Acid	40-46	noggin	Mus musculus	19-25
24817375-9	2014	CONCLUSIONS: Folate nonresponsiveness could be attributed in part to increased noggin expression in Fkbp8 (-/-) embryos, resulting in decreased Msx2 expression.	Folic Acid	13-19	noggin	Mus musculus	79-85
24817375-10	2014	Folate treatment further increases Olig2 and noggin expression, thereby exacerbating ventralization.	Folic Acid	0-6	noggin	Mus musculus	45-51
24447348-2	2014	We examined whether single nucleotide polymorphisms (SNPs) in enzymes of the folic acid pathway (folylpoly-gamma-glutamate synthetase [FPGS], gamma-glutamyl hydrolase [GGH], and methylenetetrahydrofolate reductase [MTHFR]) associate with significant adverse events (SigAE).	Folic Acid	77-87	methylenetetrahydrofolate reductase	Homo sapiens	178-213
24447348-2	2014	We examined whether single nucleotide polymorphisms (SNPs) in enzymes of the folic acid pathway (folylpoly-gamma-glutamate synthetase [FPGS], gamma-glutamyl hydrolase [GGH], and methylenetetrahydrofolate reductase [MTHFR]) associate with significant adverse events (SigAE).	Folic Acid	77-87	methylenetetrahydrofolate reductase	Homo sapiens	215-220
24627342-10	2014	A proteomics study reveals that two other genes (S-Adenosylhomocysteine hydrolase and Serine hydroxymethyltransferase2) involved in the methionine-folate cycle are also repressed by B12 in C. reinhardtii.	Folic Acid	147-153	uncharacterized protein	Chlamydomonas reinhardtii	49-81
27928289-1	2014	Folic acid has a fundamental role in central nervous system (CNS) function at all ages, especially the methionine synthase-mediated conversion of homocysteine to methionine, which is essential for nucleotide synthesis and genomic and non-genomic methylation.	Folic Acid	0-10	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	103-122
24753765-3	2014	Decreases in folate consumption due to MTHFR polymorphism may affect production rate of keratinocytes of which had faster reproduction rates with a continuous DNA turnover and this may affect the clinical picture of psoriasis.	Folic Acid	13-19	methylenetetrahydrofolate reductase	Homo sapiens	39-44
24649091-2	2014	Two important folate-metabolizing enzymes involved in the folate/homocysteine metabolic pathway are 5,10-methylenetetrahydrofolate reductase (MTHFR) and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1).	Folic Acid	14-20	methylenetetrahydrofolate reductase	Homo sapiens	105-140
24649091-2	2014	Two important folate-metabolizing enzymes involved in the folate/homocysteine metabolic pathway are 5,10-methylenetetrahydrofolate reductase (MTHFR) and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1).	Folic Acid	14-20	methylenetetrahydrofolate reductase	Homo sapiens	142-147
24649091-2	2014	Two important folate-metabolizing enzymes involved in the folate/homocysteine metabolic pathway are 5,10-methylenetetrahydrofolate reductase (MTHFR) and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1).	Folic Acid	58-64	methylenetetrahydrofolate reductase	Homo sapiens	105-140
24649091-2	2014	Two important folate-metabolizing enzymes involved in the folate/homocysteine metabolic pathway are 5,10-methylenetetrahydrofolate reductase (MTHFR) and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1).	Folic Acid	58-64	methylenetetrahydrofolate reductase	Homo sapiens	142-147
24749352-0	2014	[Study on the relationship between the MTHFR polymorphism, the level of the folic acid and the cervical cancer susceptibility].	Folic Acid	76-86	methylenetetrahydrofolate reductase	Homo sapiens	39-44
24333266-1	2014	The current study was conducted to elucidate the effect of genetic variations in one-carbon metabolism on the epigenetic regulation of major histocompatibility complex II transactivator (MHC2TA), reduced folate carrier 1 (RFC1/SLC19A1) and human leukocyte antigen (HLA)-DR in systemic lupus erythematosus (SLE).	Folic Acid	204-210	replication factor C subunit 1	Homo sapiens	222-226
24333266-7	2014	Plasma folate and thymidylate synthase (TYMS) 5"-UTR 28 bp tandem repeat showed an inverse association with methylation of RFC1 and MHC2TA.	Folic Acid	7-13	replication factor C subunit 1	Homo sapiens	123-127
24326202-6	2014	RESULTS: Association between 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C&gt;T and NTDs was significant in all stratifications (all P&lt;.05), and synergistic effects of no folate supplementation and GDM were shown on NTD occurrence.	Folic Acid	53-59	methylenetetrahydrofolate reductase	Homo sapiens	71-76
24326202-8	2014	CONCLUSIONS: MTHFR 677C&gt;T genotype, especially in case of no folate supplementation and GDM, promotes NTD occurrence.	Folic Acid	64-70	methylenetetrahydrofolate reductase	Homo sapiens	13-18
24554143-3	2014	The reduced folate carrier (RFC1) gene, rs1051266, which encodes the RFC 1, protein was analyzed for polymorphism by polymerase chain reaction-restriction fragment length polymorphism.	Folic Acid	12-18	replication factor C subunit 1	Homo sapiens	19-33
24554143-3	2014	The reduced folate carrier (RFC1) gene, rs1051266, which encodes the RFC 1, protein was analyzed for polymorphism by polymerase chain reaction-restriction fragment length polymorphism.	Folic Acid	12-18	replication factor C subunit 1	Homo sapiens	69-74
24380661-2	2014	MTHFR is a critical enzyme in folate metabolism that catalyzes the irreversible conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, thus playing a vital role in DNA synthesis and DNA methylation.	Folic Acid	30-36	methylenetetrahydrofolate reductase	Homo sapiens	0-5
24131523-2	2014	A common polymorphism (677C T) in the MTHFR gene results in reduced MTHFR activity in vivo which in turn leads to impaired folate metabolism and elevated homocysteine concentrations.	Folic Acid	123-129	methylenetetrahydrofolate reductase	Homo sapiens	38-43
24131523-2	2014	A common polymorphism (677C T) in the MTHFR gene results in reduced MTHFR activity in vivo which in turn leads to impaired folate metabolism and elevated homocysteine concentrations.	Folic Acid	123-129	methylenetetrahydrofolate reductase	Homo sapiens	68-73
24131523-9	2014	Preliminary evidence has suggested that there may be a much greater need for women with the MTHFR 677TT genotype to adhere to the specific recommendation of commencing folic acid prior to conception for the prevention of NTD, but this requires further investigation.	Folic Acid	168-178	methylenetetrahydrofolate reductase	Homo sapiens	92-97
24183284-8	2014	We conclude that the C677T MTHFR polymorphism, responsible for a reduction of the MTHFR activity in folate metabolism, may act as a genetic susceptibility factor for migraine, MA in particular among the subjects of Asian descent.	Folic Acid	100-106	methylenetetrahydrofolate reductase	Homo sapiens	27-32
24183284-8	2014	We conclude that the C677T MTHFR polymorphism, responsible for a reduction of the MTHFR activity in folate metabolism, may act as a genetic susceptibility factor for migraine, MA in particular among the subjects of Asian descent.	Folic Acid	100-106	methylenetetrahydrofolate reductase	Homo sapiens	82-87
23954881-1	2013	OBJECTIVE: Methylene-tetrahydrofolate reductase (MTHFR) is a key enzyme regulating folate metabolism and it is thought to influence DNA methylation and nucleic acid synthesis.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	49-54
23806361-1	2013	Folate transporters, including the reduced folate carrier and the proton-coupled folate transporter, encoded by Slc19a1 and Slc46a1 genes respectively, play important roles in the transport of folate across biological membranes given the hydrophilic nature of folates.	Folic Acid	43-49	solute carrier family 19 member 1	Gallus gallus	112-119
24247802-2	2013	Among them, 5,10-methylenetetrahydrofolate reductase (MTHFR) is of special interest because of its involvement in regulation of the homocysteine level in the body as a result of folate metabolism.	Folic Acid	36-42	methylenetetrahydrofolate reductase	Homo sapiens	54-59
23657144-2	2013	In order to determine how early this increase occurs, we used a murine folic acid-induced nephropathy model and found that plasma FGF23 levels increased significantly from baseline already after 1 h of AKI, with an 18-fold increase at 24 h. Similar elevations of FGF23 levels were found when AKI was induced in mice with osteocyte-specific parathyroid hormone receptor ablation or the global deletion of parathyroid hormone or the vitamin D receptor, indicating that the increase in FGF23 was independent of parathyroid hormone and vitamin D signaling.	Folic Acid	71-81	fibroblast growth factor 23	Mus musculus	130-135
23824605-11	2013	Importantly, SARDH and/or TMEFF2 KD promote increased cellular invasion, sensitize the cell to methotrexate, render the cell resistant to invasion induced by sarcosine, a metabolite from the folate-mediated 1-C metabolism pathway, and affect the expression level of enzymes involved in that pathway.	Folic Acid	191-197	sarcosine dehydrogenase	Homo sapiens	13-18
23765760-2	2013	Methylenetetrahydrofolate reductase (MTHFR) 677C&gt;T polymorphism is a genetic alteration in an enzyme involved in folate metabolism, but its effect on risk of gliomas is still uncertain.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
23422951-1	2013	PURPOSES: Methylenetetrahydrofolate reductase (MTHFR) plays a key role in folate metabolism, and folate is implicated in carcinogenesis by its role in DNA methylation, repair, and synthesis.	Folic Acid	29-35	methylenetetrahydrofolate reductase	Homo sapiens	47-52
23422951-1	2013	PURPOSES: Methylenetetrahydrofolate reductase (MTHFR) plays a key role in folate metabolism, and folate is implicated in carcinogenesis by its role in DNA methylation, repair, and synthesis.	Folic Acid	74-80	methylenetetrahydrofolate reductase	Homo sapiens	10-45
23422951-1	2013	PURPOSES: Methylenetetrahydrofolate reductase (MTHFR) plays a key role in folate metabolism, and folate is implicated in carcinogenesis by its role in DNA methylation, repair, and synthesis.	Folic Acid	74-80	methylenetetrahydrofolate reductase	Homo sapiens	47-52
23612630-1	2013	AIM: The present study attempts to understand the role of methylenetetrahydrofolate reductase C677T (MTHFR C677T) in recurrent pregnancy losses in North Indian women because of hyperhomocysteinemia in light of serum folate and vitamin B12.	Folic Acid	77-83	methylenetetrahydrofolate reductase	Homo sapiens	101-106
23522838-1	2013	Elderly women: homocysteine reduction by short-term folic acid supplementation resulting in increased glucose concentrations and affecting lipid metabolism (C677T MTHFR polymorphism).	Folic Acid	52-62	methylenetetrahydrofolate reductase	Homo sapiens	163-168
23430981-1	2013	AIMS: The C677T variant in the methylenetetrahydrofolate reductase ( MTHFR ; EC 1.5.1.20) enzyme, a key player in the folate metabolic pathway, has been associated with increased risk of migraine with aura.	Folic Acid	50-56	methylenetetrahydrofolate reductase	Homo sapiens	69-74
23816603-2	2013	Methylenetetrahydrofolate reductase (MTHFR) is an enzyme involved in the metabolism of folate.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
23819405-7	2013	A key enzyme in folate metabolism is methylenetetrahydrofolate reductase (MTHFR - methylenetetrahydrofolate reductase), and 677C&gt;T polymorphism of MTHFR gene is connected with lower enzymatic activity In several researches it was indicated that 677C&gt;T MTHFR polymorphism is an independent factor influencing homocysteine concentration in serum, and also folate concentration in serum and red blood cells.	Folic Acid	16-22	methylenetetrahydrofolate reductase	Homo sapiens	37-72
23819405-7	2013	A key enzyme in folate metabolism is methylenetetrahydrofolate reductase (MTHFR - methylenetetrahydrofolate reductase), and 677C&gt;T polymorphism of MTHFR gene is connected with lower enzymatic activity In several researches it was indicated that 677C&gt;T MTHFR polymorphism is an independent factor influencing homocysteine concentration in serum, and also folate concentration in serum and red blood cells.	Folic Acid	16-22	methylenetetrahydrofolate reductase	Homo sapiens	74-79
23819405-7	2013	A key enzyme in folate metabolism is methylenetetrahydrofolate reductase (MTHFR - methylenetetrahydrofolate reductase), and 677C&gt;T polymorphism of MTHFR gene is connected with lower enzymatic activity In several researches it was indicated that 677C&gt;T MTHFR polymorphism is an independent factor influencing homocysteine concentration in serum, and also folate concentration in serum and red blood cells.	Folic Acid	16-22	methylenetetrahydrofolate reductase	Homo sapiens	82-117
23819405-7	2013	A key enzyme in folate metabolism is methylenetetrahydrofolate reductase (MTHFR - methylenetetrahydrofolate reductase), and 677C&gt;T polymorphism of MTHFR gene is connected with lower enzymatic activity In several researches it was indicated that 677C&gt;T MTHFR polymorphism is an independent factor influencing homocysteine concentration in serum, and also folate concentration in serum and red blood cells.	Folic Acid	16-22	methylenetetrahydrofolate reductase	Homo sapiens	150-155
23819405-7	2013	A key enzyme in folate metabolism is methylenetetrahydrofolate reductase (MTHFR - methylenetetrahydrofolate reductase), and 677C&gt;T polymorphism of MTHFR gene is connected with lower enzymatic activity In several researches it was indicated that 677C&gt;T MTHFR polymorphism is an independent factor influencing homocysteine concentration in serum, and also folate concentration in serum and red blood cells.	Folic Acid	16-22	methylenetetrahydrofolate reductase	Homo sapiens	150-155
23613867-2	2013	Methionine synthase (MTR) plays a central role in folate metabolism, thereby affecting DNA methylation.	Folic Acid	50-56	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	0-19
23593229-1	2013	Methionine synthase (MTR), which plays a central role in maintaining adequate intracellular folate, methionine and normal homocysteine concentrations, was thought to be involved in the development of colorectal cancer (CRC) and colorectal adenoma (CRA) by affecting DNA methylation.	Folic Acid	92-98	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	0-19
22961839-5	2013	However, statistically significant interactions modifying CC risk were observed for DNMT1 I311V with dietary folate, methionine, vitamin B2 , and vitamin B12 intake and for MTRR I22M with dietary folate, a predefined one-carbon dietary pattern, and vitamin B6 intake.	Folic Acid	109-115	DNA methyltransferase 1	Homo sapiens	84-89
23001810-8	2013	Low folate increased Ppara and Aldh1a1 expression, and decreased Bcmo1, Sprr2a, and Bmp5 expression in BALB/c, compared to BALB/c on control diets.	Folic Acid	4-10	small proline-rich protein 2A1	Mus musculus	72-78
23112124-0	2013	Low dietary folate and methylenetetrahydrofolate reductase deficiency may lead to pregnancy complications through modulation of ApoAI and IFN-gamma in spleen and placenta, and through reduction of methylation potential.	Folic Acid	12-18	apolipoprotein A-I	Mus musculus	128-133
23219837-6	2013	The effects were more remarkable in non-invasive MCF-7 cells where we also observed 30% up-regulation of DNMT1 expression at the highest folate concentration used.	Folic Acid	137-143	DNA methyltransferase 1	Homo sapiens	105-110
23534726-2	2013	Previous studies regarding the association of folate intake and Methylenetetrahydrofolate reductase C677T polymorphism with ESCC was conflicting.	Folic Acid	46-52	methylenetetrahydrofolate reductase	Homo sapiens	64-99
23534726-9	2013	CONCLUSIONS: Our meta-analysis indicated the folate intake and MTHFR 677CT/TT are associated with the risk of ESCC, and folate showed a significant interaction with polymorphism of MTHFR C677T.	Folic Acid	120-126	methylenetetrahydrofolate reductase	Homo sapiens	181-186
23534741-7	2013	The effect of MTHFR C677T polymorphisms on the risk of gastric cancer was modified by folate intake and methylation status of MGMT (P for interaction &lt;0.05).	Folic Acid	86-92	methylenetetrahydrofolate reductase	Homo sapiens	14-19
23116396-4	2013	MTHFR plays a key role in folate metabolism and in the homeostasis of homocysteine; mutations in the enzyme lead to hyperhomocyst(e)inemia.	Folic Acid	26-32	methylenetetrahydrofolate reductase	Homo sapiens	0-5
23076526-1	2013	5,10-Methlenetetrahydrofolate reductase (MTHFR) is one of the most important enzymes for folate metabolism.	Folic Acid	23-29	methylenetetrahydrofolate reductase	Homo sapiens	41-46
23536781-1	2013	BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme for folate metabolism in humans; it is encoded by the MTHFR gene.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	49-54
23536781-1	2013	BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme for folate metabolism in humans; it is encoded by the MTHFR gene.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	133-138
23273201-1	2012	MTHFR is a key enzyme in folate metabolism that catalyzes the conversion of 5, 10&amp;mdash;methlenetetrahydrofolate (5, 10&amp;mdash; methylene THF) to 5&amp;mdash;methyltetrahydrofolate (5&amp;mdash;methyl THF), a predominant circulatory form of folate and methyl donor for the remethylation of homocysteine to methionine.	Folic Acid	25-31	methylenetetrahydrofolate reductase	Homo sapiens	0-5
23256225-3	2004	Two site-specific carboxypeptidase activities have been assigned to PSMA: N-acetylated alpha-linked acidic dipeptidase, which hydrolyzes the neuropeptide N-acetyl-aspartyl-glutamate (NAAG) in the brain to regulate release of neurotransmitters, and folate hydrolase activity, which is characterized by the cleavage of terminal glutamates from poly- and gamma-glutamated folates, which play a role in the cellular uptake of dietary folate (2).	Folic Acid	248-254	folate hydrolase 1B (pseudogene)	Homo sapiens	74-118
23057736-1	2012	BACKGROUND: MTHFR 677C&gt;T polymorphism is a genetic alteration in an enzyme involved in folate metabolism, but its effect on host susceptibility to cervical cancer is still uncertain.	Folic Acid	90-96	methylenetetrahydrofolate reductase	Homo sapiens	12-17
23016165-0	2004	(68)Ga-1,4,7-Triazacyclononane,1-glutaric acid-4,7-acetic acid-1,2-diaminoethane-gamma-5,8-dideazfolic acid (P3238) Folic acid (folate) is a water-soluble B vitamin (1) that is essential for methylation and DNA synthesis.	Folic Acid	116-126	mediator complex subunit 25	Homo sapiens	58-64
23016165-0	2004	(68)Ga-1,4,7-Triazacyclononane,1-glutaric acid-4,7-acetic acid-1,2-diaminoethane-gamma-5,8-dideazfolic acid (P3238) Folic acid (folate) is a water-soluble B vitamin (1) that is essential for methylation and DNA synthesis.	Folic Acid	128-134	mediator complex subunit 25	Homo sapiens	58-64
23016166-0	2004	(68)Ga-1,4,7-Triazacyclononane,1-glutaric acid-4,7-acetic acid-1,2-diaminoethane-gamma-folate (P3246) Folic acid (folate) is a water-soluble B vitamin (1) that is essential for methylation and DNA synthesis.	Folic Acid	102-112	mediator complex subunit 25	Homo sapiens	58-64
23016166-0	2004	(68)Ga-1,4,7-Triazacyclononane,1-glutaric acid-4,7-acetic acid-1,2-diaminoethane-gamma-folate (P3246) Folic acid (folate) is a water-soluble B vitamin (1) that is essential for methylation and DNA synthesis.	Folic Acid	87-93	mediator complex subunit 25	Homo sapiens	58-64
23166529-7	2012	To identify the genetic association with gastric cancer, we selected 17 SNPs sites in folate pathway-associated genes of MTHFR, MTR, and MTRR and tested in 1,261 gastric cancer patients and 375 healthy controls.	Folic Acid	86-92	methylenetetrahydrofolate reductase	Homo sapiens	121-126
22929917-0	2012	Association of folate intake, dietary habits, smoking and COX-2 promotor -765G&gt;C polymorphism with K-ras mutation in patients with colorectal cancer.	Folic Acid	15-21	KRAS proto-oncogene, GTPase	Homo sapiens	102-107
22929917-10	2012	The mean red blood cell folic acid level was lower in the K-ras positive group (100.96+-51.3 ng/ml) than the negative group (216.6+-166.4 ng/ml), (P&lt;0.01).	Folic Acid	24-34	KRAS proto-oncogene, GTPase	Homo sapiens	58-63
22929917-13	2012	CONCLUSION: RBC folic acid was significantly deficient in CRC (colorectal cancer) patients with K-ras mutations in comparison with CRC patients free of the mutations, suggesting that folic acid may be a risk factor for K-ras mutation development.	Folic Acid	16-26	KRAS proto-oncogene, GTPase	Homo sapiens	96-101
22929917-13	2012	CONCLUSION: RBC folic acid was significantly deficient in CRC (colorectal cancer) patients with K-ras mutations in comparison with CRC patients free of the mutations, suggesting that folic acid may be a risk factor for K-ras mutation development.	Folic Acid	16-26	KRAS proto-oncogene, GTPase	Homo sapiens	219-224
22929917-13	2012	CONCLUSION: RBC folic acid was significantly deficient in CRC (colorectal cancer) patients with K-ras mutations in comparison with CRC patients free of the mutations, suggesting that folic acid may be a risk factor for K-ras mutation development.	Folic Acid	183-193	KRAS proto-oncogene, GTPase	Homo sapiens	219-224
22706675-2	2012	This study tested the hypothesis that maternal folic acid supplementation before or during pregnancy reduces AL risk, accounting for the SNPs rs1801133 (C677T) and rs1801131 (A1298C) in MTHFR and rs1801394 (A66G) and rs1532268 (C524T) in MTRR, assumed to modify folate metabolism.	Folic Acid	47-57	methylenetetrahydrofolate reductase	Homo sapiens	186-191
22693118-9	2012	The method was sensitive enough to measure the comprehensive erythrocyte folate distribution in a Down"s syndrome patient with extremely low folate, bearing the C677T mutation in the gene encoding for methylenetetrahydrofolate reductase.	Folic Acid	73-79	methylenetetrahydrofolate reductase	Homo sapiens	201-236
22693118-9	2012	The method was sensitive enough to measure the comprehensive erythrocyte folate distribution in a Down"s syndrome patient with extremely low folate, bearing the C677T mutation in the gene encoding for methylenetetrahydrofolate reductase.	Folic Acid	141-147	methylenetetrahydrofolate reductase	Homo sapiens	201-236
21951971-3	2012	Methylenetetrahydrofolate reductase (MTHFR) genes play a key role not only in folate metabolism but also in esophagus, stomach, pancreatic carcinoma, and acute leukemias.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
22424391-3	2012	Our purpose was to test whether the MTHFR C677T (rs1801133) polymorphism affecting folate metabolism is associated with the occurrence or severity of npHI.	Folic Acid	83-89	methylenetetrahydrofolate reductase	Homo sapiens	36-41
22424391-8	2012	Among controls the known effect of MTHFR 677T on plasma total homocysteine was more pronounced in men than in women (p&lt;0.00004 for genotype-sex interaction) suggesting that in Poland folate deficiency is more prevalent in males.	Folic Acid	186-192	methylenetetrahydrofolate reductase	Homo sapiens	35-40
22492374-8	2012	After stratification by period of follow-up, the inverse association of MTHFR with CVD mortality was significant only in the period after introduction of mandatory folic acid fortification.	Folic Acid	164-174	methylenetetrahydrofolate reductase	Homo sapiens	72-77
22495907-8	2012	The T allele of MTHFR rs1801133 was associated with a 2.8-fold increase of risk among Hispanic women whose dietary folate intake was &lt;= 25th centile.	Folic Acid	115-121	methylenetetrahydrofolate reductase	Homo sapiens	16-21
22495907-9	2012	The C allele of MTHFR rs1801131 was associated with a two-fold increase of risk (OR = 2.0, 95% CI = 1.0-3.9) only among those whose dietary folate intake was &gt;25th centile.	Folic Acid	140-146	methylenetetrahydrofolate reductase	Homo sapiens	16-21
22495907-11	2012	Maternal functional variants in MTHFR gene may interact with dietary folate intake and modify the conotruncal defects risk in the offspring.	Folic Acid	69-75	methylenetetrahydrofolate reductase	Homo sapiens	32-37
22084937-1	2012	In this study, our aim was to investigate the association of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism on the vitamin B12 therapy response in 95 patients with vitamin B12 deficiency and 92 healthy control subjects using vitamin B12, plasma total homocysteine (tHcy), and folate as the main measure of outcome.	Folic Acid	80-86	methylenetetrahydrofolate reductase	Homo sapiens	98-103
22180326-8	2012	MMP-2 and MMP-9 activities were increased in embryos and decidua from diabetic rats and decreased with safflower oil and folic acid supplementations.	Folic Acid	121-131	matrix metallopeptidase 9	Rattus norvegicus	10-15
22152927-8	2012	People homozygous for the common C677T variant in the gene encoding the folate-metabolising enzyme, methylenetetrahydrofolate reductase (MTHFR), typically have a 14-21% higher risk of CVD.	Folic Acid	72-78	methylenetetrahydrofolate reductase	Homo sapiens	100-135
22152927-8	2012	People homozygous for the common C677T variant in the gene encoding the folate-metabolising enzyme, methylenetetrahydrofolate reductase (MTHFR), typically have a 14-21% higher risk of CVD.	Folic Acid	72-78	methylenetetrahydrofolate reductase	Homo sapiens	137-142
22883450-0	2012	[Inhibitory effect of folic acid/polyamide-amine as a miR-7 vector on the growth of glioma in mice].	Folic Acid	22-32	leukocyte immunoglobulin like receptor B1	Homo sapiens	54-59
22265912-9	2012	Furthermore, the transfection of mPPS-FA/DNA complexes in CHO-1 cells could be competitively blocked by free folic acid molecules.	Folic Acid	109-119	kinesin family member 23	Homo sapiens	58-63
22367721-6	2012	For the MTHFR polymorphisms, RRs (95% CIs) were 0.62 (0.44-0.90) for 677TT versus CC/CT and 0.68 (0.31-1.51) for 1298CC versus AC/AA, and these lower-risk genotypes were associated with lower circulating plasma folate levels.	Folic Acid	211-217	methylenetetrahydrofolate reductase	Homo sapiens	8-13
22370993-1	2012	Folate has been implicated in cardiovascular disease with atypical antipsychotic (AAPs) use, and individuals with methylenetetrahydrofolate reductase (MTHFR) and catechol-O-methyl transferase (COMT) variants are at greater risk.	Folic Acid	0-6	methylenetetrahydrofolate reductase	Homo sapiens	151-156
22147198-2	2012	The steady-state accumulation of folate seems to depend on the activity of two enzymes: folylpolyglutamate synthetase (FPGS), which adds glutamate residues, and gamma-glutamyl hydrolase (GGH), which removes them, enabling it to be transported across the biological membranes.	Folic Acid	33-39	folylpolyglutamate synthase	Rattus norvegicus	88-117
22147198-2	2012	The steady-state accumulation of folate seems to depend on the activity of two enzymes: folylpolyglutamate synthetase (FPGS), which adds glutamate residues, and gamma-glutamyl hydrolase (GGH), which removes them, enabling it to be transported across the biological membranes.	Folic Acid	33-39	folylpolyglutamate synthase	Rattus norvegicus	119-123
22344247-11	2012	In univariate analyses, clinical variables including sex, age, and folate supplementation in addition to variations in MTHFR, MTR, and SLC25A32 were associated with differential intracellular folate redox concentrations.	Folic Acid	192-198	methylenetetrahydrofolate reductase	Homo sapiens	119-124
26105097-2	2012	In addition there are a number of ATP-dependent transporters which have also recently been shown to be involved in folate transport; these include ABCB1, ABCC2 and BCRP (ABCG2).	Folic Acid	115-121	ATP binding cassette subfamily C member 2	Homo sapiens	154-159
22220685-9	2012	Finally, SHMT1 and SHMT2 expression were significantly correlated with those of other Folate and Methionine Cycle genes at both the messenger RNA and protein levels.	Folic Acid	86-92	serine hydroxymethyltransferase 2	Homo sapiens	19-24
23125859-2	2012	The objective was to determine whether relationships exist between the methylene-tetrahydrofolate reductase (MTHFR) polymorphisms and risk of colorectal cancer (CRC) and examine whether the risk is modified by level of folate intake.	Folic Acid	91-97	methylenetetrahydrofolate reductase	Homo sapiens	109-114
23430891-1	2012	Our aim was to monitor folate status in five creatine transporter deficient (CRTR) patients undergoing glycine/L-arginine (Gly/Arg) therapy after the finding of severe hyperhomocysteinemia in one of these cases.Five male patients (age range: 12-20; median = 13 years) genetically confirmed of CRTR deficiency, who were treated with oral glycine (200 mg/kg/day) and L-arginine (400 mg/kg/day) twice a day for 9 months.	Folic Acid	23-29	solute carrier family 6 member 8	Homo sapiens	77-81
23430891-8	2012	In all cases, after 3 months of folate supplementation (5 mg/day), both serum folate and tHcys concentrations returned to normal values.In conclusion, prior to the start of long-term Gly/Arg therapy, the monitoring of folate and plasma tHcys values, together with study of the 677C T polymorphism of the MTHFR gene, seems necessary in order to correct hyperhomocysteinemia by means of folate supplementation.	Folic Acid	32-38	methylenetetrahydrofolate reductase	Homo sapiens	304-309
22470444-12	2012	Individuals with MTHFR 677CT or TT genotypes were at a greater risk of hyperhomocysteinemia in folate and vitamin B12 deficiencies and high blood lead (p value &lt;0.05) level.	Folic Acid	95-101	methylenetetrahydrofolate reductase	Homo sapiens	17-22
22057276-6	2011	In this study, the impact of increased Shmt1 expression on folate-mediated one-carbon metabolism was determined in mice that overexpress the Shmt1 cDNA (Shmt1tg+ mice).	Folic Acid	59-65	serine hydroxymethyltransferase 1 (soluble)	Mus musculus	39-44
22057276-7	2011	Compared with wild type mice, Shmt1tg+ mice exhibited elevated SHMT1 and TYMS protein levels in tissues and evidence for impaired homocysteine remethylation but surprisingly exhibited depressed levels of nuclear SHMT1 and TYMS, lower rates of nuclear de novo thymidylate biosynthesis, and a nearly 10-fold increase in uracil content in hepatic nuclear DNA when fed a folate- and choline-deficient diet.	Folic Acid	367-373	serine hydroxymethyltransferase 1 (soluble)	Mus musculus	30-35
22238794-14	2004	Separate chapters in MICAD (http://www.micad.nih.gov/) discuss the studies performed with [(18)F]-folate-1 (6), [(18)F]-folate-MTX-8 (7), and [(18)F]-folate-MTX-9 (8).	Folic Acid	120-126	metaxin 1	Mus musculus	127-130
22238794-14	2004	Separate chapters in MICAD (http://www.micad.nih.gov/) discuss the studies performed with [(18)F]-folate-1 (6), [(18)F]-folate-MTX-8 (7), and [(18)F]-folate-MTX-9 (8).	Folic Acid	120-126	metaxin 1	Mus musculus	127-130
22238797-12	2004	This chapter describes the results obtained with [(18)F]-folate-MTX-9.	Folic Acid	57-63	metaxin 1	Mus musculus	64-67
22238799-14	2004	Separate chapters in MICAD (http://www.micad.nih.gov/) discuss the studies performed with [(18)F]-folate-2 (6), [(18)F]-folate-MTX-8 (7), and [(18)F]-folate-MTX-9 (8).	Folic Acid	120-126	metaxin 1	Mus musculus	127-130
22238799-14	2004	Separate chapters in MICAD (http://www.micad.nih.gov/) discuss the studies performed with [(18)F]-folate-2 (6), [(18)F]-folate-MTX-8 (7), and [(18)F]-folate-MTX-9 (8).	Folic Acid	120-126	metaxin 1	Mus musculus	127-130
22238801-13	2004	This chapter describes the results obtained with [(18)F]-folate-MTX-8.	Folic Acid	57-63	metaxin 1	Mus musculus	64-67
21525199-8	2011	Although a co-association with folate intake in childhood could explain this relation, the maternal methylenetetrahydrofolate reductase (MTHFR) genotype affected spine BMD independently of the child MTHFR genotype, which suggests that maternal folate status has an independent effect on bone development of offspring.	Folic Acid	119-125	methylenetetrahydrofolate reductase	Homo sapiens	137-142
21982573-0	2011	Rapid synthesis and in vitro and in vivo evaluation of folic acid derivatives labeled with fluorine-18 for PET imaging of folate receptor-positive tumors.	Folic Acid	55-65	thyroid stimulating hormone receptor	Mus musculus	107-110
21367581-1	2011	OBJECTIVE: The aim was to investigate whether pregnancy-induced changes in total homocysteine (tHcy) are associated with folate and vitamin B12 nutritional status, genetic C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) enzyme, and gestation outcome at a time when folic acid supplementation started to be recommended in the Spanish health system.	Folic Acid	287-297	methylenetetrahydrofolate reductase	Homo sapiens	198-233
21690209-5	2011	By contrast, the combination of the heterozygous MTHFR genotype with folate deficiency in the samples from preeclamptic pregnancies was characterized by a statistically significant decrease in the Met content, a trend toward increased Hcy levels and a tight association between metabolically directly and indirectly related compounds, e.g. positive relation between Hcy versus cysteine and folate versus GSH and negative relation between folate versus Hcy and both Hcy and cysteine versus GSH.	Folic Acid	69-75	methylenetetrahydrofolate reductase	Homo sapiens	49-54
21690209-5	2011	By contrast, the combination of the heterozygous MTHFR genotype with folate deficiency in the samples from preeclamptic pregnancies was characterized by a statistically significant decrease in the Met content, a trend toward increased Hcy levels and a tight association between metabolically directly and indirectly related compounds, e.g. positive relation between Hcy versus cysteine and folate versus GSH and negative relation between folate versus Hcy and both Hcy and cysteine versus GSH.	Folic Acid	390-396	methylenetetrahydrofolate reductase	Homo sapiens	49-54
21690209-5	2011	By contrast, the combination of the heterozygous MTHFR genotype with folate deficiency in the samples from preeclamptic pregnancies was characterized by a statistically significant decrease in the Met content, a trend toward increased Hcy levels and a tight association between metabolically directly and indirectly related compounds, e.g. positive relation between Hcy versus cysteine and folate versus GSH and negative relation between folate versus Hcy and both Hcy and cysteine versus GSH.	Folic Acid	390-396	methylenetetrahydrofolate reductase	Homo sapiens	49-54
22303578-1	2011	INTRODUCTION: Methylenetetrahydrofolate reductase (MTHFR) C677T is involved in folate and homocysteine metabolism.	Folic Acid	33-39	methylenetetrahydrofolate reductase	Homo sapiens	51-56
22303578-11	2011	CONCLUSION: MTHFR C677T polymorphism plays an important role in influencing the folate and homocysteine metabolism.	Folic Acid	80-86	methylenetetrahydrofolate reductase	Homo sapiens	12-17
21723457-14	2011	To avoid the risk of neural tube defects, pregnant women with a MTHFR mutation may require higher than normally recommended doses of folic acid supplementation for optimum health.	Folic Acid	133-143	methylenetetrahydrofolate reductase	Homo sapiens	64-69
21508090-0	2011	MTHFR 677C-&gt;T genotype is associated with folate and homocysteine concentrations in a large, population-based, double-blind trial of folic acid supplementation.	Folic Acid	45-51	methylenetetrahydrofolate reductase	Homo sapiens	0-5
21508090-0	2011	MTHFR 677C-&gt;T genotype is associated with folate and homocysteine concentrations in a large, population-based, double-blind trial of folic acid supplementation.	Folic Acid	136-146	methylenetetrahydrofolate reductase	Homo sapiens	0-5
21508090-3	2011	OBJECTIVE: We sought to determine whether the MTHFR 677C T genotype modifies the response to folic acid supplementation during and 3 mo after discontinuation of supplementation.	Folic Acid	93-103	methylenetetrahydrofolate reductase	Homo sapiens	46-51
21508090-7	2011	RESULTS: Plasma and RBC folate and homocysteine concentrations were associated with MTHFR genotype throughout the supplementation trial, regardless of folic acid dose.	Folic Acid	24-30	methylenetetrahydrofolate reductase	Homo sapiens	84-89
21508090-8	2011	MTHFR TT was associated with lower folate concentrations, and the trend of TT &lt; CC was maintained at even the highest doses.	Folic Acid	35-41	methylenetetrahydrofolate reductase	Homo sapiens	0-5
21510664-5	2011	We now show that nuclear extracts of HeLa cells contain LSD1 that is associated with folate.	Folic Acid	85-91	lysine demethylase 1A	Homo sapiens	56-60
21510664-6	2011	Using the method of back-scattering interferometry, we have measured the binding of various forms of folate to both full-length LSD1 and a truncated form of LSD1 in free solution.	Folic Acid	101-107	lysine demethylase 1A	Homo sapiens	128-132
21510664-6	2011	Using the method of back-scattering interferometry, we have measured the binding of various forms of folate to both full-length LSD1 and a truncated form of LSD1 in free solution.	Folic Acid	101-107	lysine demethylase 1A	Homo sapiens	157-161
21781484-5	2011	The relationship of folate levels and DNMT1 protein expression showed inverse correlation (r = -0.186, P = 0.001).	Folic Acid	20-26	DNA methyltransferase 1	Homo sapiens	38-43
21781484-6	2011	The results in our study indicated that there was an additive interaction between low-level of serum folate and high-expression of DNMT1 protein related to the risk of CIN and SCC, with OR value as 2.50 (95%CI: 1.21 - 9.22) and 6.03 (95%CI: 2.79 - 21.72) respectively.	Folic Acid	101-107	DNA methyltransferase 1	Homo sapiens	131-136
21346251-6	2011	In vivo folate uptake experiments demonstrated a systemic folate deficiency caused by disruption of PCFT-mediated intestinal folate uptake, thus confirming in vivo a critical and nonredundant role of the PCFT protein in intestinal folate transport and erythropoiesis.	Folic Acid	8-14	solute carrier family 46, member 1	Mus musculus	204-208
21346251-6	2011	In vivo folate uptake experiments demonstrated a systemic folate deficiency caused by disruption of PCFT-mediated intestinal folate uptake, thus confirming in vivo a critical and nonredundant role of the PCFT protein in intestinal folate transport and erythropoiesis.	Folic Acid	58-64	solute carrier family 46, member 1	Mus musculus	100-104
21346251-6	2011	In vivo folate uptake experiments demonstrated a systemic folate deficiency caused by disruption of PCFT-mediated intestinal folate uptake, thus confirming in vivo a critical and nonredundant role of the PCFT protein in intestinal folate transport and erythropoiesis.	Folic Acid	58-64	solute carrier family 46, member 1	Mus musculus	204-208
21346251-6	2011	In vivo folate uptake experiments demonstrated a systemic folate deficiency caused by disruption of PCFT-mediated intestinal folate uptake, thus confirming in vivo a critical and nonredundant role of the PCFT protein in intestinal folate transport and erythropoiesis.	Folic Acid	58-64	solute carrier family 46, member 1	Mus musculus	100-104
21346251-6	2011	In vivo folate uptake experiments demonstrated a systemic folate deficiency caused by disruption of PCFT-mediated intestinal folate uptake, thus confirming in vivo a critical and nonredundant role of the PCFT protein in intestinal folate transport and erythropoiesis.	Folic Acid	58-64	solute carrier family 46, member 1	Mus musculus	204-208
21208488-8	2011	Feeding the FS diet to Abeta-injected rats enriched brain folate levels and reduced mtDNA4834 deletion in the hippocampal and medullary regions compared with corresponding tissues of Abeta+FD rats (P &lt; 0 05).	Folic Acid	58-64	amyloid beta precursor protein	Rattus norvegicus	23-28
21346092-0	2011	Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice.	Folic Acid	52-58	serine hydroxymethyltransferase 1 (soluble)	Mus musculus	0-5
21346092-2	2011	Serine hydroxymethyltransferase (SHMT1) partitions folate-derived one-carbon units to thymidylate biosynthesis at the expense of cellular methylation, and therefore SHMT1-deficient mice are a model to investigate the metabolic origin of folate-associated pathologies.	Folic Acid	51-57	serine hydroxymethyltransferase 1 (soluble)	Mus musculus	33-38
21346092-2	2011	Serine hydroxymethyltransferase (SHMT1) partitions folate-derived one-carbon units to thymidylate biosynthesis at the expense of cellular methylation, and therefore SHMT1-deficient mice are a model to investigate the metabolic origin of folate-associated pathologies.	Folic Acid	237-243	serine hydroxymethyltransferase 1 (soluble)	Mus musculus	33-38
21346092-7	2011	RESULTS: Shmt1(+/-) and Shmt1(-/-) embryos exhibited exencephaly in response to maternal folate and choline deficiency.	Folic Acid	89-95	serine hydroxymethyltransferase 1 (soluble)	Mus musculus	9-14
21346092-7	2011	RESULTS: Shmt1(+/-) and Shmt1(-/-) embryos exhibited exencephaly in response to maternal folate and choline deficiency.	Folic Acid	89-95	serine hydroxymethyltransferase 1 (soluble)	Mus musculus	24-29
21346092-10	2011	CONCLUSIONS: SHMT1 is the only folate-metabolizing enzyme that has been shown to affect neural tube closure in mice by directly inhibiting folate metabolism.	Folic Acid	31-37	serine hydroxymethyltransferase 1 (soluble)	Mus musculus	13-18
21346092-10	2011	CONCLUSIONS: SHMT1 is the only folate-metabolizing enzyme that has been shown to affect neural tube closure in mice by directly inhibiting folate metabolism.	Folic Acid	139-145	serine hydroxymethyltransferase 1 (soluble)	Mus musculus	13-18
21346092-11	2011	These results provide evidence that disruption of Shmt1 expression causes NTDs by impairing thymidylate biosynthesis and shows that changes in the expression of genes that encode folate-dependent enzymes may be key determinates of NTD risk.	Folic Acid	179-185	serine hydroxymethyltransferase 1 (soluble)	Mus musculus	50-55
21255267-10	2011	Although polymorphisms in the MTHFR gene may cause disturbances in folate metabolism, they do not appear to be accompanied by changes in cognitive functioning in old age.	Folic Acid	67-73	methylenetetrahydrofolate reductase	Homo sapiens	30-35
21437563-7	2011	Folate insufficiency remained associated with cataract in older men who had adequate vitamin B2, B6 and B12 status.	Folic Acid	0-6	immunoglobulin kappa variable 5-2	Homo sapiens	93-99
21295329-2	2011	In vitro studies found that mercury inhibited methionine synthase, an enzyme that interacts with vitamin B-12 and folate to regenerate the amino acid methionine from homocysteine, and inhibition of methionine synthase diverted homocysteine to cysteine and glutathione synthesis.	Folic Acid	114-120	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	46-65
21385350-9	2011	In addition, a subgroup analysis demonstrated that the favorable effect of the MTHFR 677T allele on the risk of developing hearing impairment was independent of folate and homocysteine level, whereas plasma total homocysteine level was independently associated with an increased risk of developing hearing impairment.	Folic Acid	161-167	methylenetetrahydrofolate reductase	Homo sapiens	79-84
21281325-6	2011	These results suggest the possibility that initiating folic acid supplementation prior to pregnancy may reduce the risk of having a LRD-affected pregnancy, especially in women whose offspring inherit one or two copies of the MTHFR 677T variant.	Folic Acid	54-64	methylenetetrahydrofolate reductase	Homo sapiens	225-230
21233333-2	2011	The disrupted gene in the mutant encoded the plastidial isoform of folylpolyglutamate synthetase (FPGS), previously designated as AtDFB, an enzyme that catalyzes the addition of glutamate residues to the folate molecule to form folylpolyglutamates.	Folic Acid	204-210	DHFS-FPGS homolog B	Arabidopsis thaliana	130-135
21233333-4	2011	The accumulation of monoglutamylated forms of some folate classes in atdfb was consistent with impaired FPGS function.	Folic Acid	51-57	DHFS-FPGS homolog B	Arabidopsis thaliana	69-74
21233333-8	2011	The root growth and quiescent center defects of atdfb were rescued by exogenous application of 5-formyl-tetrahydrofolate, a stable folate that was readily converted to metabolically active folates.	Folic Acid	114-120	DHFS-FPGS homolog B	Arabidopsis thaliana	48-53
21233333-8	2011	The root growth and quiescent center defects of atdfb were rescued by exogenous application of 5-formyl-tetrahydrofolate, a stable folate that was readily converted to metabolically active folates.	Folic Acid	189-196	DHFS-FPGS homolog B	Arabidopsis thaliana	48-53
21233333-9	2011	Collectively, our results indicate that AtDFB is the predominant FPGS isoform that generates polyglutamylated folate cofactors to support C1 metabolism required for meristem maintenance and cell expansion during postembryonic root development in Arabidopsis.	Folic Acid	110-116	DHFS-FPGS homolog B	Arabidopsis thaliana	40-45
21625172-7	2011	We calculated the heritability and tested for associations between the MTHFR C677T functional variant and response to folic acid supplementation.	Folic Acid	118-128	methylenetetrahydrofolate reductase	Homo sapiens	71-76
21109973-4	2011	In the present study, we sought to determine the following: i) genotype frequencies of MTHFR and MTR involved in folate metabolism in cases and cancer-free controls; and ii) the methylation status of three candidate genes (p16INK4A, p73 and hMLH1) in plasma related to the folate and homocysteine levels.	Folic Acid	113-119	methylenetetrahydrofolate reductase	Homo sapiens	87-92
21109973-5	2011	From genotype frequency analysis, individuals homozygous for the MTHFR 677TT genotype had a significantly reduced risk of developing colorectal cancer compared with those harboring the MTHFR 677CC genotype (OR, 0.206; 95% CI, 0.070-0.604; P=0.005), and had a lower plasma folate concentration than those with the MTHFR 677CC+CT genotype (P&lt;0.05).	Folic Acid	272-278	methylenetetrahydrofolate reductase	Homo sapiens	65-70
22046205-7	2011	MTHFR C677T and A1298C gene polymorphisms were found to be similar in patients with and without MTX-related adverse events.In conclusion, A1298C and C677T polymorphisms in the MTHFR gene, were not related with MTX-related toxicity in RA patients receiving folate supplementation.	Folic Acid	256-262	methylenetetrahydrofolate reductase	Homo sapiens	176-181
21799811-1	2011	BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme of folate and methionine metabolism, making it crucial for DNA synthesis and methylation.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	49-54
20468076-7	2010	In case-control analysis, a significant increase in the reduced folate carrier (RFC1) G allele frequency was found among case mothers, but not among fathers or affected children.	Folic Acid	64-70	replication factor C subunit 1	Homo sapiens	80-84
21090237-0	2010	[Polymorphic variants of folate metabolizing genes (C677T and A1298C MTHFR, C1420T SHMT1 and G1958A MTHFD) are not associated with the risk of breast cancer in West Siberian Region of Russia].	Folic Acid	25-31	methylenetetrahydrofolate reductase	Homo sapiens	69-74
21090237-2	2010	We investigated the role of polymorphisms of folate metabolizing genes MTHFR (C677T and A1298C), SHMT1 (C1420T) and MTHFD (G1258A) in genetic susceptibility to this type of cancer.	Folic Acid	45-51	methylenetetrahydrofolate reductase	Homo sapiens	71-76
20544798-11	2010	In Caucasians, folate derivative levels were associated with vitamin use, B(12), and polymorphisms in MTHFR, TYMS, and RFC1.	Folic Acid	15-21	methylenetetrahydrofolate reductase	Homo sapiens	102-107
20672355-2	2010	Many folate metabolism gene variants have been investigated, but only a few substantial associations have been established, the C677T polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene being one of the most significant.	Folic Acid	5-11	methylenetetrahydrofolate reductase	Homo sapiens	154-189
20672355-2	2010	Many folate metabolism gene variants have been investigated, but only a few substantial associations have been established, the C677T polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene being one of the most significant.	Folic Acid	5-11	methylenetetrahydrofolate reductase	Homo sapiens	191-196
20451895-9	2010	CONCLUSION: Folic acid supplementation alone or with myoinositol prevented alcohol potentiation of Wnt/beta-catenin signaling that allowed normal gene activation and cardiogenesis.	Folic Acid	12-22	catenin (cadherin associated protein), beta 1	Mus musculus	103-115
20451541-3	2010	The 5" untranslated region of the hepatocellular Reduced folate carrier (Rfc1; Slc19a1) exhibits AhR binding sites termed dioxin responsive elements (DRE) that have as yet only been found in the promoter region of prototypical TCDD target genes.	Folic Acid	57-63	replication factor C subunit 1	Rattus norvegicus	73-77
20451541-3	2010	The 5" untranslated region of the hepatocellular Reduced folate carrier (Rfc1; Slc19a1) exhibits AhR binding sites termed dioxin responsive elements (DRE) that have as yet only been found in the promoter region of prototypical TCDD target genes.	Folic Acid	57-63	aryl hydrocarbon receptor	Rattus norvegicus	97-100
20451541-4	2010	Rfc1 mediated transport of reduced folates and antifolate drugs such as methotrexate (MTX) plays an essential role in physiological folate homeostasis and MTX cancer chemotherapy.	Folic Acid	35-42	replication factor C subunit 1	Rattus norvegicus	0-4
20451541-4	2010	Rfc1 mediated transport of reduced folates and antifolate drugs such as methotrexate (MTX) plays an essential role in physiological folate homeostasis and MTX cancer chemotherapy.	Folic Acid	35-41	replication factor C subunit 1	Rattus norvegicus	0-4
20185185-3	2010	GNMT is a mediator in the methionine and folate cycles, and the homotetrameric form enzymatically transfers a methyl group from S-adenosylmethionine (SAM) to glycine forming S-adenosylhomocysteine (SAH) and sarcosine.	Folic Acid	41-47	glycine N-methyltransferase	Fundulus heteroclitus	0-4
20374669-3	2010	Inherited polymorphisms in key folate metabolic pathway genes, MTHFR and MTHFD, may influence the efficiency of folate metabolism and plasma level of homocysteine.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	63-68
20374669-3	2010	Inherited polymorphisms in key folate metabolic pathway genes, MTHFR and MTHFD, may influence the efficiency of folate metabolism and plasma level of homocysteine.	Folic Acid	112-118	methylenetetrahydrofolate reductase	Homo sapiens	63-68
20053979-10	2010	CONCLUSIONS: FRalpha and PCFT are expressed in retinal Muller cells and colocalize in the endosomal compartment, suggesting that the two proteins may work coordinately to mediate folate uptake.	Folic Acid	179-185	solute carrier family 46, member 1	Mus musculus	25-29
20356773-1	2010	Methylenetetrahydrofolate reductase (MTHFR) is a key enzymatic component of the folate cycle, converting 5,10-methylenetetrahydrofolate into 5-methyltetrahydrofolate, the methyl donor for remethylation of homocysteine into methionine.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
20386493-4	2010	RESULTS: RBC folate concentrations were significantly associated with MTHFR 677C&gt;T (P=0.002), MTRR 66A&gt;G (P&lt;0.0001), MTHFD1 1958G&gt;A (P=0.001) and SHMT 1420C&gt;T (P=0.012), whereas no association of these polymorphisms with disease activity was observed.	Folic Acid	13-19	methylenetetrahydrofolate reductase	Homo sapiens	70-75
19591231-2	2010	Folic acid was coupled to the surface amino groups of G5-PAMAM dendrimer (G5D) through a 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide bond, and ASODNs corresponding to rat epidermal growth factor receptor (EGFR) were then complexed with FA-PAMAM.	Folic Acid	0-10	epidermal growth factor receptor	Rattus norvegicus	175-207
19591231-2	2010	Folic acid was coupled to the surface amino groups of G5-PAMAM dendrimer (G5D) through a 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide bond, and ASODNs corresponding to rat epidermal growth factor receptor (EGFR) were then complexed with FA-PAMAM.	Folic Acid	0-10	epidermal growth factor receptor	Rattus norvegicus	209-213
19591231-6	2010	The current study demonstrates the suitability of folate-PAMAM dendrimer conjugates for efficient EGFR ASODN delivery into glioma cells, wherein they release the ASODN from the FA-PAMAM to knock down EGFR expression in C6 glioma cells, both in vitro and in vivo.	Folic Acid	50-56	epidermal growth factor receptor	Rattus norvegicus	98-102
19591231-6	2010	The current study demonstrates the suitability of folate-PAMAM dendrimer conjugates for efficient EGFR ASODN delivery into glioma cells, wherein they release the ASODN from the FA-PAMAM to knock down EGFR expression in C6 glioma cells, both in vitro and in vivo.	Folic Acid	50-56	epidermal growth factor receptor	Rattus norvegicus	200-204
19821069-8	2010	Genetic analyses revealed homozygosity for the A allele of methylenetetrahydrofolate reductase (MTHFR) c.1298A&gt;C (p.E429A), whereas other genetic variants of folate/methionine metabolism associated with MTX neurotoxicity were not present.	Folic Acid	78-84	methylenetetrahydrofolate reductase	Homo sapiens	96-101
20221815-0	2010	MTHFR gene polymorphism and its relationship with plasma homocysteine and folate in a North Indian population.	Folic Acid	74-80	methylenetetrahydrofolate reductase	Homo sapiens	0-5
20221815-2	2010	This study evaluates MTHFR gene polymorphism and its relationship with plasma homocysteine and folate levels in a healthy North Indian population.	Folic Acid	95-101	methylenetetrahydrofolate reductase	Homo sapiens	21-26
20213658-7	2010	CONCLUSIONS: Our results suggest that the T allele of MTHFR C677T could be associated with susceptibility to SSNHL, and even imply that this mutation could be a risk factor that is independent of blood folic acid and homocysteine.	Folic Acid	202-212	methylenetetrahydrofolate reductase	Homo sapiens	54-59
19577428-0	2010	Dietary folate and vitamin B12 intake before diagnosis decreases gastric cancer mortality risk among susceptible MTHFR 677TT carriers.	Folic Acid	8-14	methylenetetrahydrofolate reductase	Homo sapiens	113-118
19577428-6	2010	RESULTS: MTHFR 677TT carriers with low folate and vitamin B12 intakes had the lowest survival rate in cases of gastric cancer.	Folic Acid	39-45	methylenetetrahydrofolate reductase	Homo sapiens	9-14
19967264-4	2010	We review here the correlation between homocysteine metabolism and the disorders described above with genetic variants on genes coding for enzymes of homocysteine metabolism relevant to clinical practice, especially common variants of the MTHFR gene, 677C&gt;T and 1298A&gt;C. We also discuss the management of hyperhomocysteinemia with folic acid supplementation and fortification of folic acid and the impact of a decrease in the prevalence of congenital anomalies and a decline in the incidence of stroke mortality.	Folic Acid	337-347	methylenetetrahydrofolate reductase	Homo sapiens	239-244
19967264-4	2010	We review here the correlation between homocysteine metabolism and the disorders described above with genetic variants on genes coding for enzymes of homocysteine metabolism relevant to clinical practice, especially common variants of the MTHFR gene, 677C&gt;T and 1298A&gt;C. We also discuss the management of hyperhomocysteinemia with folic acid supplementation and fortification of folic acid and the impact of a decrease in the prevalence of congenital anomalies and a decline in the incidence of stroke mortality.	Folic Acid	385-395	methylenetetrahydrofolate reductase	Homo sapiens	239-244
20645920-2	2010	MRP1-5 can collectively confer resistance to natural product anticancer drugs and their conjugated metabolites, platinum compounds, folate antimetabolites, nucleoside and nucleotide analogs, and alkylating agents.	Folic Acid	132-138	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Mus musculus	0-4
20113291-1	2010	The frequency of the methylenetetrahydrofolate reductase enzyme (MTHFR) C677T mutation was determined using polymerase chain reaction (PCR) and with measurement of plasma total homocysteine (tHcy), folate, vitamins B6, B12 and disease severity in 102 SS children from Yemen.	Folic Acid	40-46	methylenetetrahydrofolate reductase	Homo sapiens	65-70
19803478-4	2009	To demonstrate the viability and efficiency of this approach, folic acid (FA) was selected as a targeting vector because the preparation of FA-based imaging probes used for SPECT, PET, MRI, and NIRF by reported synthetic strategies is usually difficult to achieve and often results in low overall yields.	Folic Acid	62-72	interleukin 17B	Homo sapiens	194-198
19178944-1	2009	The reported correlation of defects in 5,10-methylenetetrahydrofolate reductase (MTHFR), the key enzyme of folate metabolism, with modulated risk for acute lymphoblastic leukemia (ALL) is ambiguous.	Folic Acid	63-69	methylenetetrahydrofolate reductase	Homo sapiens	81-86
19178944-4	2009	Mutations in the MTHFR gene decrease the onset risk of ALL with relapse in the setting of no folate supplementation in pregnancy, but not of relapse-free ALL.	Folic Acid	93-99	methylenetetrahydrofolate reductase	Homo sapiens	17-22
19552531-7	2009	Both mRNA and protein levels of Oat1, Oat3 and Bcrp were significantly decreased in folic acid-induced acute renal failure rats.	Folic Acid	84-94	solute carrier family 22 member 6	Rattus norvegicus	32-36
19552531-8	2009	Based on the finding that belotecan is a substrate of OAT1 but not of OAT3, the decrease in CLr of belotecan in folic acid-induced acute renal failure could, therefore, mainly be attributed to the down-regulation of Oat1 and Bcrp, in addition to the decrease in glomerular filtration rate.	Folic Acid	112-122	solute carrier family 22 member 6	Rattus norvegicus	216-220
19650776-2	2009	As folate transport across cell membranes is mediated in part by the reduced folate carrier (RFC1), variants within SLC19A1, the gene that encodes RFC1, may influence disease risk via an effect on folate and/or homocysteine levels.	Folic Acid	77-83	replication factor C subunit 1	Homo sapiens	93-97
19650776-2	2009	As folate transport across cell membranes is mediated in part by the reduced folate carrier (RFC1), variants within SLC19A1, the gene that encodes RFC1, may influence disease risk via an effect on folate and/or homocysteine levels.	Folic Acid	77-83	replication factor C subunit 1	Homo sapiens	147-151
19687280-8	2009	However, compared with the basal diet, jejunal mRNA levels of RFC were decreased (P&lt;0.05) in hens fed with the 5-methyltetrahydrofolate diet, but the reduction did not reach significance (P=0.077) in the hens fed the folic acid diet.	Folic Acid	220-230	solute carrier family 19 member 1	Gallus gallus	62-65
19687280-10	2009	The wide tissue distribution of RFC transcripts is suggestive of an important role of RFC in the process of folate transport in the chicken.	Folic Acid	108-114	solute carrier family 19 member 1	Gallus gallus	32-35
19687280-10	2009	The wide tissue distribution of RFC transcripts is suggestive of an important role of RFC in the process of folate transport in the chicken.	Folic Acid	108-114	solute carrier family 19 member 1	Gallus gallus	86-89
19687280-11	2009	Moreover, dietary folate supplementation could downregulate the jejunal mRNA expression of RFC.	Folic Acid	18-24	solute carrier family 19 member 1	Gallus gallus	91-94
23105845-3	2009	MTHFR is a flavo enzyme and a key player in folate metabolism and changes in its activity could modify the susceptibility to Acute Lymphoblastic Leukemia (ALL).	Folic Acid	44-50	methylenetetrahydrofolate reductase	Homo sapiens	0-5
19954067-1	2009	OBJECTIVE: To evaluate the relationship between dietary folate intake and genetic polymorphisms of 5, 10-methylenetetrahydrofolate reductase (MTHFR) with reference to breast cancer risk.	Folic Acid	56-62	methylenetetrahydrofolate reductase	Homo sapiens	142-147
19954067-13	2009	Among individuals with the MTHFR A1298C A/A genotype,adjusted OR for breast cancer were 0.89 (95% CI: 0.62 - 1.27) and 1.69 (95% CI: 1.20 - 2.36) for the second to the third tertile of folate intake compared with the highest folate intake group (X2trend = 11.372, P = 0.001).	Folic Acid	185-191	methylenetetrahydrofolate reductase	Homo sapiens	27-32
19954067-13	2009	Among individuals with the MTHFR A1298C A/A genotype,adjusted OR for breast cancer were 0.89 (95% CI: 0.62 - 1.27) and 1.69 (95% CI: 1.20 - 2.36) for the second to the third tertile of folate intake compared with the highest folate intake group (X2trend = 11.372, P = 0.001).	Folic Acid	225-231	methylenetetrahydrofolate reductase	Homo sapiens	27-32
19435794-1	2009	To investigate the relationship between liver-type fatty acid-binding protein (L-FABP), a biomarker of chronic kidney disease, in the kidney and the degree of tubulointerstitial damage, folic acid (FA)-induced nephropathy was studied in a mouse model system.	Folic Acid	186-196	fatty acid binding protein 1, liver	Mus musculus	79-85
19144510-4	2009	Two common non-synonymous variants, the C677T (Ala222Val) and A1298C (Glu429Ala), were described for the MTHFR gene and associated with a decreased enzymatic activity and an alteration of intracellular folate distribution.	Folic Acid	202-208	methylenetetrahydrofolate reductase	Homo sapiens	105-110
19450180-2	2009	Recently, functionally significant SNPs in 5,10-methylenetetrahydrofolate reductase (MTHFR), a critical enzyme for intracellular folate homeostasis and metabolism, have been identified and characterized.	Folic Acid	67-73	methylenetetrahydrofolate reductase	Homo sapiens	85-90
19450180-3	2009	The MTHFR SNPs are ideal candidates for investigating the role of SNPs in cancer risk modification and treatment because of their well-defined and highly relevant biochemical effects on intracellular folate composition and one-carbon transfer reactions.	Folic Acid	200-206	methylenetetrahydrofolate reductase	Homo sapiens	4-9
19447376-2	2009	Numerous studies of MTHFR, encoding methylenetetrahydrofolate reductase, which catalyzes the rate-limiting step of folic acid biosynthesis, have shown inconsistent association of two common hypomorphic allelic variants, C677T and A1298C, in nsCL/P patients and, in some cases, their mothers.	Folic Acid	115-125	methylenetetrahydrofolate reductase	Homo sapiens	20-25
19447376-2	2009	Numerous studies of MTHFR, encoding methylenetetrahydrofolate reductase, which catalyzes the rate-limiting step of folic acid biosynthesis, have shown inconsistent association of two common hypomorphic allelic variants, C677T and A1298C, in nsCL/P patients and, in some cases, their mothers.	Folic Acid	115-125	methylenetetrahydrofolate reductase	Homo sapiens	36-71
19264913-8	2009	Our data revealed that hyperhomocysteinemia could increase Abeta production through the enhanced expression of gamma-secretase and APP phosphorylation, causing memory deficits that could be rescued by folate and vitamin-B12 treatment in these rats.	Folic Acid	201-207	amyloid beta precursor protein	Rattus norvegicus	59-64
19211833-1	2009	We previously showed that provision of the folate recommended dietary allowance and either 300, 550, 1100, or 2200 mg/d choline for 12 wk resulted in diminished folate status and a tripling of plasma total homocysteine (tHcy) in men with the methylenetetrahydrofolate reductase (MTHFR) 677TT genotype.	Folic Acid	43-49	methylenetetrahydrofolate reductase	Homo sapiens	242-277
19211833-1	2009	We previously showed that provision of the folate recommended dietary allowance and either 300, 550, 1100, or 2200 mg/d choline for 12 wk resulted in diminished folate status and a tripling of plasma total homocysteine (tHcy) in men with the methylenetetrahydrofolate reductase (MTHFR) 677TT genotype.	Folic Acid	43-49	methylenetetrahydrofolate reductase	Homo sapiens	279-284
19211833-10	2009	Thus, in folate-deplete men, several factors with roles in 1-carbon metabolism interact with the MTHFR C677T genotype to affect plasma tHcy.	Folic Acid	9-15	methylenetetrahydrofolate reductase	Homo sapiens	97-102
19633796-3	2009	It has been proposed that C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase (MTHFR), an enzyme involved in the folate pathway, could be related to its efficacy and toxicity.	Folic Acid	79-85	methylenetetrahydrofolate reductase	Homo sapiens	97-102
19110071-2	2009	The basis for its therapeutic efficacy is the inhibition of dihydrofolate reductase (DHFR), a key enzyme in the folic acid (FA) metabolism.	Folic Acid	112-122	dihydrofolate reductase	Mus musculus	60-83
19110071-2	2009	The basis for its therapeutic efficacy is the inhibition of dihydrofolate reductase (DHFR), a key enzyme in the folic acid (FA) metabolism.	Folic Acid	112-122	dihydrofolate reductase	Mus musculus	85-89
19141696-7	2009	These interactions, which were not seen in NHANES III before fortification, imply that, in vitamin B-12 deficiency, high folate status is associated with impaired activity of the 2 vitamin B-12-dependent enzymes, methionine synthase and MMA-coenzyme A mutase.	Folic Acid	121-127	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	213-258
18511109-10	2009	We observed a significant correlation between folate and Hcy (r: 0.48; p=0.005) among homozygous for MTHFR.	Folic Acid	46-52	methylenetetrahydrofolate reductase	Homo sapiens	101-106
18840514-2	2009	Susceptibility to esophageal cancer may be modified by functional polymorphisms in genes along the folate metabolic pathway, such as methylenetetrahydrofolate reductase (MTHFR).	Folic Acid	99-105	probable methylenetetrahydrofolate reductase	Nicotiana tabacum	133-168
18840514-2	2009	Susceptibility to esophageal cancer may be modified by functional polymorphisms in genes along the folate metabolic pathway, such as methylenetetrahydrofolate reductase (MTHFR).	Folic Acid	99-105	probable methylenetetrahydrofolate reductase	Nicotiana tabacum	170-175
20030812-10	2009	The most pronounced MTHFR-breast cancer risks were observed among women with the lowest intakes of dietary folate (P for interaction = 0.02) and total (diet plus supplemental) vitamin B(6) (P for interaction = 0.01), with no significant increased risks among women with higher intakes.	Folic Acid	107-113	methylenetetrahydrofolate reductase	Homo sapiens	20-25
19852428-5	2009	Molecular analysis of 12 genetic polymorphisms involved in the folate metabolism revealed that the mother is heterozygous for the MTHFR C677T and TC2 A67G polymorphisms, and homozygous for the mutant MTRR A66G polymorphism.	Folic Acid	63-69	methylenetetrahydrofolate reductase	Homo sapiens	130-135
19811436-8	2009	PGA patients with autoimmune thyroid disease and the TNF-alpha; -308 AA genotype showed the highest prevalence of thyroid autoantibodies (TPO, P = 0.04; Tg, P = 0.003).	Folic Acid	0-3	thyroid peroxidase	Homo sapiens	138-141
19533869-1	2008	In order to prevent Alzheimer disease (AD), relationship between single nucleotide polymorphisms (SNPs) of methylene tetrahydrofolate reductase (MTHFR) and folate-homocysteine metabolism was studied.	Folic Acid	127-133	methylenetetrahydrofolate reductase	Homo sapiens	145-150
18669903-2	2008	We hypothesized that if folate pathway inhibition is the mechanism of cancer preventive activities of EGCG, then the protective effect against breast cancer would be stronger among women with low dietary folate intake and the high-activity methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TYMS) genotypes.	Folic Acid	24-30	methylenetetrahydrofolate reductase	Homo sapiens	240-275
18669903-2	2008	We hypothesized that if folate pathway inhibition is the mechanism of cancer preventive activities of EGCG, then the protective effect against breast cancer would be stronger among women with low dietary folate intake and the high-activity methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TYMS) genotypes.	Folic Acid	24-30	methylenetetrahydrofolate reductase	Homo sapiens	277-282
18843035-0	2008	A prospective study of dietary folate and vitamin B and colon cancer according to microsatellite instability and KRAS mutational status.	Folic Acid	31-37	KRAS proto-oncogene, GTPase	Homo sapiens	113-117
18644786-7	2008	This study suggests that mitochondrial SHMT-derived one-carbon units are essential for folate-mediated one-carbon metabolism in the cytoplasm.	Folic Acid	87-93	serine hydroxymethyltransferase 1 (soluble)	Mus musculus	39-43
18165972-4	2008	The MTHFR 677TT genotype, and to a lesser extent the 677CT genotype, is associated with a significant elevation in the circulating concentrations of homocysteine and a decrease in serum folate concentrations.	Folic Acid	186-192	methylenetetrahydrofolate reductase	Homo sapiens	4-9
18322814-2	2008	A C/T transition at position 677 in the gene encoding methlylenetetrahydrofolate reductase (MTHFR C677T) has been reported to interact with folate intake to modulate colorectal adenoma recurrence or cancer risk.	Folic Acid	74-80	methylenetetrahydrofolate reductase	Homo sapiens	92-97
18322814-9	2008	No significant interaction was noted for total folate and MTHFR genotype, though an increased risk of recurrence noted for the MTHFR CT genotype was statistically significant only for those individuals with below median intake of total folate.	Folic Acid	236-242	methylenetetrahydrofolate reductase	Homo sapiens	127-132
18703816-2	2008	Low folate levels, along with genetic polymorphisms in key enzymes such as methylene tetrahydrofolate reductase (MTHFR), can cause DNA hypomethylation and aberrant CpG methylation, which have been associated with colorectal tumor development.	Folic Acid	4-10	methylenetetrahydrofolate reductase	Homo sapiens	75-111
18703816-2	2008	Low folate levels, along with genetic polymorphisms in key enzymes such as methylene tetrahydrofolate reductase (MTHFR), can cause DNA hypomethylation and aberrant CpG methylation, which have been associated with colorectal tumor development.	Folic Acid	4-10	methylenetetrahydrofolate reductase	Homo sapiens	113-118
18703816-6	2008	High folate intake was associated with a decreased risk for colorectal adenoma (odds ratio, 0.47; 95% CI, 0.30-0.73; P(trend), &lt;0.001), which was modified by MTHFR 1298 genotype (P(interaction) = 0.006).	Folic Acid	5-11	methylenetetrahydrofolate reductase	Homo sapiens	161-166
18703816-9	2008	Our data suggest that dietary folate intake may be an important determinant for premalignant colorectal disease development but not colorectal cancer, an association that is modified by MTHFR genotype.	Folic Acid	30-36	methylenetetrahydrofolate reductase	Homo sapiens	186-191
18768511-1	2008	Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
18768511-2	2008	We assessed the association between two common MTHFR variants, 677C&gt;T and 1298A&gt;C, and adenoma recurrence in the context of a randomized double- blind clinical trial of aspirin use and folate supplementation.	Folic Acid	191-197	methylenetetrahydrofolate reductase	Homo sapiens	47-52
18594211-1	2008	Cobalamin-dependent methionine synthase, with a cofactor of vitamin B12, catalyzes the reaction of 5-methyltetrahydrofolate and homocysteine to form methionine and tetrahydrofolate, which takes a core position in folate cycle, one-carbon-unit transfer, and sulfur amino acid pathways.	Folic Acid	117-123	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	0-39
18601742-4	2008	METHODS: 223 incident papillary thyroid cancer cases and 513 controls recruited from Saudi Arabian population were analyzed for the association between polymorphisms in genes encoding folic acid metabolizing enzymes MTHFR and six xenobiotics-metabolizing enzymes including CYP1A1 T3801C, C4887A, GSTP1 A1578G, C2293T, GSTM1, GSTT1, NAT2 G590A, NQO*1 C609T, using PCR-RELP.	Folic Acid	184-194	methylenetetrahydrofolate reductase	Homo sapiens	216-221
18614746-10	2008	CONCLUSIONS: The MTHFR 677C--&gt;T polymorphism was associated with significant differences in serum folate and homocysteine concentrations in the US population before folic acid fortification.	Folic Acid	168-178	methylenetetrahydrofolate reductase	Homo sapiens	17-22
18580170-9	2008	Plasma 5-methyl-tetrahydrofolate concentrations increased uniformly by 20% after nitrous oxide anesthesia, indicating the inactivation of methionine synthase and subsequent folate trapping.	Folic Acid	26-32	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	138-157
18616362-10	2008	CONCLUSION: While the inverse relation between the mother"s having the MTHFR C677T variant and both CL+/-P and CP suggests perturbation of maternal folate metabolism is of etiological importance, contrasting relations between maternal postpartum levels of RBC and serum folate by type of cleft are difficult to explain.	Folic Acid	148-154	methylenetetrahydrofolate reductase	Homo sapiens	71-76
18616362-10	2008	CONCLUSION: While the inverse relation between the mother"s having the MTHFR C677T variant and both CL+/-P and CP suggests perturbation of maternal folate metabolism is of etiological importance, contrasting relations between maternal postpartum levels of RBC and serum folate by type of cleft are difficult to explain.	Folic Acid	270-276	methylenetetrahydrofolate reductase	Homo sapiens	71-76
18595133-11	2008	CONCLUSION: We conclude that high concentrations of serum folate/vitamin B(12) levels are associated with the risk of promoter methylation in tumor-specific genes, and this relationship is modified by MTHFR C677T genotypes.	Folic Acid	58-64	methylenetetrahydrofolate reductase	Homo sapiens	201-206
18446861-1	2008	Studies on the structure of the methylenetetrahydrofolate reductase (MTHFR) gene and the mechanisms by which folate may reduce homocysteine levels in bacteria and in humans have provided a rationale to understand the conflicting epidemiological observations between the studies on the 677C-T and 1298A-C MTHFR polymorphic variants, and the risk of having an infant with Down syndrome (DS).	Folic Acid	51-57	methylenetetrahydrofolate reductase	Homo sapiens	69-74
18187048-10	2008	The changes in CDX2 and CDX1 expression determined by methyl group deprivation may constitute one of the mechanisms sustaining the protective role attributed to folate in colon cancer.	Folic Acid	161-167	caudal type homeobox 2	Homo sapiens	15-19
18451149-7	2008	We show that changes in MDM2 expression alter folate metabolism in cells as evidenced by MDM2-dependent alteration in the sensitivity of cells to the antifolate drug methotrexate.	Folic Acid	46-52	MDM2 proto-oncogene	Homo sapiens	24-28
18451149-7	2008	We show that changes in MDM2 expression alter folate metabolism in cells as evidenced by MDM2-dependent alteration in the sensitivity of cells to the antifolate drug methotrexate.	Folic Acid	46-52	MDM2 proto-oncogene	Homo sapiens	89-93
18560705-8	2008	In this regard, we recommend the administration of folic acid in women in search of pregnancy due to the high frequency of heterozygous and homozygous for MTHFR C677T mutation in our population.	Folic Acid	51-61	methylenetetrahydrofolate reductase	Homo sapiens	155-160
18400109-0	2008	Microarray analysis of E9.5 reduced folate carrier (RFC1; Slc19a1) knockout embryos reveals altered expression of genes in the cubilin-megalin multiligand endocytic receptor complex.	Folic Acid	36-42	replication factor C subunit 1	Homo sapiens	52-56
18400109-0	2008	Microarray analysis of E9.5 reduced folate carrier (RFC1; Slc19a1) knockout embryos reveals altered expression of genes in the cubilin-megalin multiligand endocytic receptor complex.	Folic Acid	36-42	cubilin	Homo sapiens	127-134
18400109-6	2008	The identification of alterations in gene expression and signaling pathways involved in the observed dysmorphology following inactivation of RFC1-mediated folate transport are the focus of this investigation.	Folic Acid	155-161	replication factor C subunit 1	Homo sapiens	141-145
18400109-12	2008	CONCLUSION: Inactivation of RFC1 impacts the expression of several ligands and interacting proteins in the cubilin-amnionless-megalin complex that are involved in the maternal-fetal transport of folate and other nutrients, lipids and morphogens such as sonic hedgehog (Shh) and retinoids that play critical roles in normal embryogenesis.	Folic Acid	195-201	replication factor C subunit 1	Homo sapiens	28-32
18400109-12	2008	CONCLUSION: Inactivation of RFC1 impacts the expression of several ligands and interacting proteins in the cubilin-amnionless-megalin complex that are involved in the maternal-fetal transport of folate and other nutrients, lipids and morphogens such as sonic hedgehog (Shh) and retinoids that play critical roles in normal embryogenesis.	Folic Acid	195-201	cubilin	Homo sapiens	107-114
18053808-0	2008	Distinct association of SLC19A1 polymorphism -43T>C with red cell folate levels and of MTHFR polymorphism 677C>T with plasma folate levels.	Folic Acid	125-131	methylenetetrahydrofolate reductase	Homo sapiens	87-92
18053808-4	2008	RESULTS: The non-wild type allele of SLC19A1 polymorphism -43T>C was associated with low red cell folate levels and the non-wild type allele of MTHFR polymorphism 677C>T with low plasma folate levels.	Folic Acid	186-192	methylenetetrahydrofolate reductase	Homo sapiens	144-149
18053808-5	2008	CONCLUSION: SLC19A1 and MTHFR genes are differently associated with red cell and plasma folate levels.	Folic Acid	88-94	methylenetetrahydrofolate reductase	Homo sapiens	24-29
18605945-1	2008	BACKGROUND: 5,10-Methylenetetrahydrofolate reductase (MTHFR) plays a central role in folate metabolism.	Folic Acid	36-42	methylenetetrahydrofolate reductase	Homo sapiens	54-59
18473861-7	2008	We also present our work on the development of a novel anti-cancer target, methylenetetrahydrofolate reductase (MTHFR), a key enzyme of both folate and methionine metabolism.	Folic Acid	94-100	methylenetetrahydrofolate reductase	Homo sapiens	112-117
18421185-5	2008	In multivariable linear regression analysis, GGT activity was independently associated with homocysteine concentration, independent of age, gender, folate, vitamin B12 and serum creatinine levels.	Folic Acid	148-154	gamma-glutamyltransferase 1	Homo sapiens	45-48
17725378-1	2008	UNLABELLED: The MTHFR C677T polymorphism is associated with mildly elevated homocysteine levels when folate and/or riboflavin status is low.	Folic Acid	101-107	methylenetetrahydrofolate reductase	Homo sapiens	16-21
17725378-5	2008	INTRODUCTION: The MTHFR C677T polymorphism is associated with mildly elevated homocysteine (Hcy) levels in the presence of low folate and/or riboflavin status.	Folic Acid	127-133	methylenetetrahydrofolate reductase	Homo sapiens	18-23
18181979-2	2008	Recent human and animal studies emphasized alterations caused by 13-CRA administration on folate-dependent, one-carbon metabolism.	Folic Acid	90-96	myotubularin related protein 11	Homo sapiens	68-71
18181979-4	2008	OBJECTIVES: We determine whether a short-term supplementation with 13-CRA alters folate status and homocysteinemia in young and elderly healthy human subjects.	Folic Acid	81-87	myotubularin related protein 11	Homo sapiens	70-73
18480590-0	2008	Serum folate and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism adjusted for folate intake.	Folic Acid	36-42	methylenetetrahydrofolate reductase	Homo sapiens	54-59
18480590-1	2008	BACKGROUND: Serum folate concentration is lower in individuals with the methylenetetrahydrofolate reductase (MTHFR) 677TT genotype than in those with the MTHFR 677CC or 677CT genotypes.	Folic Acid	18-24	methylenetetrahydrofolate reductase	Homo sapiens	72-107
18480590-1	2008	BACKGROUND: Serum folate concentration is lower in individuals with the methylenetetrahydrofolate reductase (MTHFR) 677TT genotype than in those with the MTHFR 677CC or 677CT genotypes.	Folic Acid	18-24	methylenetetrahydrofolate reductase	Homo sapiens	109-114
18480590-1	2008	BACKGROUND: Serum folate concentration is lower in individuals with the methylenetetrahydrofolate reductase (MTHFR) 677TT genotype than in those with the MTHFR 677CC or 677CT genotypes.	Folic Acid	18-24	methylenetetrahydrofolate reductase	Homo sapiens	154-159
18804702-6	2008	In this chapter, we consider the role that MTHFR plays in relation to folate metabolism and the possible contribution made in relation to certain important clinical outcomes.	Folic Acid	70-76	methylenetetrahydrofolate reductase	Homo sapiens	43-48
17891601-9	2007	It may be postulated that the risk of higher MTX toxicity in patients with decreased MTHFR activity could be neutralized by the normally folate rich diet in Mexico.	Folic Acid	137-143	methylenetetrahydrofolate reductase	Homo sapiens	85-90
17927652-0	2007	Efficacy of folic acid in children with migraine, hyperhomocysteinemia and MTHFR polymorphisms.	Folic Acid	12-22	methylenetetrahydrofolate reductase	Homo sapiens	75-80
17927652-3	2007	We supplemented 16 children with migraine, hyperhomocysteinemia, and MTHFR polymorphisms with folic acid and obtained a resolution/reduction of migraine attacks.	Folic Acid	94-104	methylenetetrahydrofolate reductase	Homo sapiens	69-74
18033026-7	2007	The treatment of CBS deficiency depends on vitamin B6, whereas MTHFR deficiency can be efficiently treated by vitamin B12, folic acid, and betaine.	Folic Acid	123-133	methylenetetrahydrofolate reductase	Homo sapiens	63-68
17436311-7	2007	We confirmed the strong associations of MTHFR c.665C&gt;T with tHcy and folate, but also observed significant (P&lt;0.01) changes in metabolite concentrations according to other gene polymorphisms.	Folic Acid	72-78	methylenetetrahydrofolate reductase	Homo sapiens	40-45
17709451-1	2007	Adequate folate availability is necessary to sustain normal DNA synthesis and normal patterns of DNA methylation and these features of DNA can be modified by methylenetetrahydrofolate reductase (MTHFR) C677T genotype.	Folic Acid	9-15	methylenetetrahydrofolate reductase	Homo sapiens	158-193
17709451-1	2007	Adequate folate availability is necessary to sustain normal DNA synthesis and normal patterns of DNA methylation and these features of DNA can be modified by methylenetetrahydrofolate reductase (MTHFR) C677T genotype.	Folic Acid	9-15	methylenetetrahydrofolate reductase	Homo sapiens	195-200
17156840-1	2007	Methylenetetrahydrofolate reductase (MTHFR) is an enzyme involved in folate metabolism and DNA methylation.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
17602711-6	2007	The protective effect of the homozygous variant TT form of the MTHFR genotype (C677T) on the risk of colorectal cancer seems to be modified by the level of methyl diets, that is, by folate, which has a protective effect, or conversely by alcohol.	Folic Acid	182-188	methylenetetrahydrofolate reductase	Homo sapiens	63-68
17602711-7	2007	Recommendation of higher intake of folate and lower intake of alcohol to the target population, especially those with TT genotype of MTHFR, may be an effective preventive approach against colorectal cancer.	Folic Acid	35-41	methylenetetrahydrofolate reductase	Homo sapiens	133-138
17451848-9	2007	Search and prevention of potential risk factors are required in all patients; determination of MTHFR genotype may be of several interests as folate supplementation.	Folic Acid	141-147	methylenetetrahydrofolate reductase	Homo sapiens	95-100
17621650-1	2007	BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) of the folate metabolism pathway is a candidate gene for neural tube defects (NTDs).	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	49-54
17436239-1	2007	Folates are carriers of one-carbon units and are metabolized by 5,10-methylenetetrahydrofolate reductase (MTHFR) and other enzymes that use riboflavin, cobalamin, or vitamin B6 as cofactors.	Folic Acid	0-7	methylenetetrahydrofolate reductase	Homo sapiens	64-104
17436239-1	2007	Folates are carriers of one-carbon units and are metabolized by 5,10-methylenetetrahydrofolate reductase (MTHFR) and other enzymes that use riboflavin, cobalamin, or vitamin B6 as cofactors.	Folic Acid	0-7	methylenetetrahydrofolate reductase	Homo sapiens	106-111
17445539-9	2007	The present data indicate an association between homocysteine and BAFMD and reduced BAFMD in individuals with the MTHFR nucleotide 677 T/T genotype, despite similar blood values for folate and homocysteine.	Folic Acid	182-188	methylenetetrahydrofolate reductase	Homo sapiens	114-119
17440589-1	2007	OBJECTIVE: To study the relationship between 5,10-methylenetetrahydrofolate reductase(MTHFR) genetic polymorphism and arsenic metabolism and the role of folate in it.	Folic Acid	69-75	methylenetetrahydrofolate reductase	Homo sapiens	86-91
17523926-8	2007	CONCLUSION: Polymorphisms in methylenetetrahydrofolate reductase are potentially correctable with folic acid supplementation; however, further evaluation is required in adequately powered prospective clinical trials.	Folic Acid	98-108	methylenetetrahydrofolate reductase	Homo sapiens	29-64
17011719-11	2007	The role of homocysteine and the vitamin B-complex, especially folic acid, in these changes in DNA transcription would vary according to the polymorphism of the methylenetetrahydrofolate reductase gene.	Folic Acid	63-73	methylenetetrahydrofolate reductase	Homo sapiens	161-196
16962770-2	2006	Reduced folate carrier (RFC1, also named SLC19A1) is an essential folate transporter and functions as a bidirectional anion exchanger, taking up folate cofactors and exporting various organic anions.	Folic Acid	8-14	replication factor C subunit 1	Homo sapiens	24-28
16962770-2	2006	Reduced folate carrier (RFC1, also named SLC19A1) is an essential folate transporter and functions as a bidirectional anion exchanger, taking up folate cofactors and exporting various organic anions.	Folic Acid	66-72	replication factor C subunit 1	Homo sapiens	24-28
16962770-3	2006	A G80A polymorphism in RFC1 gene has been shown to be associated with alterations in folate and homocysteine metabolism in healthy individuals.	Folic Acid	85-91	replication factor C subunit 1	Homo sapiens	23-27
17087956-1	2006	BACKGROUND &amp; AIMS: Methylenetetrahydrofolate reductase (MTHFR) is involved in intracellular folate homeostasis and metabolism.	Folic Acid	42-48	methylenetetrahydrofolate reductase	Homo sapiens	60-65
17087956-2	2006	We assessed 2 polymorphisms in the MTHFR gene (C677T and A1298C) in relation to colorectal adenoma recurrence and conducted analyses to investigate their joint effects with plasma and dietary markers of folate status.	Folic Acid	203-209	methylenetetrahydrofolate reductase	Homo sapiens	35-40
17087956-8	2006	CONCLUSIONS: We propose that the effect of the MTHFR genotypes on increasing risk of adenoma recurrence in the presence of a low folate status is through their increase in homocysteine concentrations, which in turn could result in DNA hypomethylation via pathways involving S-adenosylhomocysteine.	Folic Acid	129-135	methylenetetrahydrofolate reductase	Homo sapiens	47-52
16997330-0	2006	Influence of DNA repair gene polymorphisms of hOGG1, XRCC1, XRCC3, ERCC2 and the folate metabolism gene MTHFR on chromosomal aberration frequencies.	Folic Acid	81-87	methylenetetrahydrofolate reductase	Homo sapiens	104-109
16997330-1	2006	We have studied the effect of genetic polymorphisms in the DNA repair genes hOGG1, XRCC1, XRCC3, ERCC2 and the MTHFR gene in the folate metabolism on the frequencies of cells with chromosomal aberrations (CA), chromosome-type aberrations (CSA), chromatid-type aberrations (CTA), chromatid breaks (CTB) and chromatid gaps (CTG) scored in peripheral blood lymphocytes from 651 Norwegian subjects of Caucasian descendant.	Folic Acid	129-135	methylenetetrahydrofolate reductase	Homo sapiens	111-116
17105984-3	2006	We conducted a meta-analysis to summarize the available evidence from observational studies on this issue and a meta-analysis of the association between a common polymorphism in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, a key enzyme in folate metabolism, and breast cancer risk.	Folic Acid	206-212	methylenetetrahydrofolate reductase	Homo sapiens	224-229
16777985-1	2006	Methylenetetrahydrofolate reductase (MTHFR) balances the pool of folate coenzymes in one-carbon metabolism for DNA synthesis and methylation, both are implicated in carcinogenesis.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
16777985-3	2006	To evaluate the C677T and A1298C functional polymorphisms in the MTHFR gene and their associations with breast cancer risk, as well as the potential modifying effect by plasma folate status on the MTHFR-associated risk, a hospital-based case-control study was conducted on a Taiwanese population consisting of 146 histologically confirmed incident breast cancer cases and their 285 age-matched controls without a history of cancer.	Folic Acid	176-182	methylenetetrahydrofolate reductase	Homo sapiens	197-202
16524711-5	2006	Serum folate (P=.065) and RBC folate (P=.022) concentrations were lower and plasma tHcy was higher (P=.039) in women with the MTHFR 677 TT genotype relative to the CC genotype.	Folic Acid	6-12	methylenetetrahydrofolate reductase	Homo sapiens	126-131
16524711-5	2006	Serum folate (P=.065) and RBC folate (P=.022) concentrations were lower and plasma tHcy was higher (P=.039) in women with the MTHFR 677 TT genotype relative to the CC genotype.	Folic Acid	30-36	methylenetetrahydrofolate reductase	Homo sapiens	126-131
16524711-7	2006	These data suggest that a doubling of food folate intake will lead to marked improvements in folate status in women with the MTHFR 677 CC or TT genotype.	Folic Acid	43-49	methylenetetrahydrofolate reductase	Homo sapiens	125-130
16524711-7	2006	These data suggest that a doubling of food folate intake will lead to marked improvements in folate status in women with the MTHFR 677 CC or TT genotype.	Folic Acid	93-99	methylenetetrahydrofolate reductase	Homo sapiens	125-130
17071478-1	2006	Methylenetetrahydrofolate reductase (MTHFR) is an essential enzyme in the metabolism of folate.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
16920564-1	2006	Methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS) play key roles in intracellular folate metabolism.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
16900509-9	2006	Patients with Ki-ras mutated tumors had lower plasma folate (24 ng/dl) than those bearing nonmutated tumors (37 ng/dl).	Folic Acid	53-59	KRAS proto-oncogene, GTPase	Homo sapiens	14-20
16900509-10	2006	Patients with G-&gt;T Ki-ras mutations had the lowest folate level (22 ng/dl), followed by those with G-&gt;A mutations (25 ng/dl).	Folic Acid	54-60	KRAS proto-oncogene, GTPase	Homo sapiens	22-28
16900509-11	2006	CONCLUSIONS: Ki-ras mutated colorectal tumors have a higher mucin production and higher differentiation, and are associated with lower plasma folate levels and a relatively poorer disease outcome.	Folic Acid	142-148	KRAS proto-oncogene, GTPase	Homo sapiens	13-19
16936384-5	2006	STATISTICAL ANALYSIS: MTHFR gene polymorphism was correlated with serum folic acid, Vitamin B12 and Hcy levels; family history of stroke in first-degree relatives; and dietary habits; employing Chi-square test.	Folic Acid	72-82	methylenetetrahydrofolate reductase	Homo sapiens	22-27
16936384-12	2006	In 3 patients with MTHFR TT alleles, Hcy was elevated in all 3, low folic acid in 2 and family history of stroke in 1 patient.	Folic Acid	68-78	methylenetetrahydrofolate reductase	Homo sapiens	19-24
16495369-1	2006	Studies from our laboratory and others have characterized different aspects of the intestinal folate uptake process and have shown that the reduced folate carrier (RFC) is expressed in the gut and plays a role in the uptake process.	Folic Acid	94-100	solute carrier family 19 (folate transporter), member 1	Mus musculus	164-167
16495369-1	2006	Studies from our laboratory and others have characterized different aspects of the intestinal folate uptake process and have shown that the reduced folate carrier (RFC) is expressed in the gut and plays a role in the uptake process.	Folic Acid	148-154	solute carrier family 19 (folate transporter), member 1	Mus musculus	164-167
16495369-2	2006	Little, however, is known about the actual contribution of the RFC system toward total folate uptake by the enterocytes.	Folic Acid	87-93	solute carrier family 19 (folate transporter), member 1	Mus musculus	63-66
16495369-4	2006	In this study, we describe the use of the new approach of lentivirus-mediated short hairpin RNA (shRNA) to selectively silence the endogenous RFC of the rat-derived intestinal epithelial cells (IEC-6), an established in vitro model for folate uptake, and examined the effect of such silencing on folate uptake.	Folic Acid	236-242	solute carrier family 19 (folate transporter), member 1	Mus musculus	142-145
16495369-4	2006	In this study, we describe the use of the new approach of lentivirus-mediated short hairpin RNA (shRNA) to selectively silence the endogenous RFC of the rat-derived intestinal epithelial cells (IEC-6), an established in vitro model for folate uptake, and examined the effect of such silencing on folate uptake.	Folic Acid	296-302	solute carrier family 19 (folate transporter), member 1	Mus musculus	142-145
16495369-9	2006	These results demonstrate that the RFC system is the major (if not the only) folate uptake system that is functional in intestinal epithelial cells.	Folic Acid	77-83	solute carrier family 19 (folate transporter), member 1	Mus musculus	35-38
16541270-1	2006	BACKGROUND: Low folate intake and changes in folate metabolism due to polymorphisms in the methylentetrahydrofolate reductase (MTHFR) gene have been associated with myelomagenesis.	Folic Acid	16-22	methylenetetrahydrofolate reductase	Homo sapiens	91-125
16541270-1	2006	BACKGROUND: Low folate intake and changes in folate metabolism due to polymorphisms in the methylentetrahydrofolate reductase (MTHFR) gene have been associated with myelomagenesis.	Folic Acid	16-22	methylenetetrahydrofolate reductase	Homo sapiens	127-132
16541270-1	2006	BACKGROUND: Low folate intake and changes in folate metabolism due to polymorphisms in the methylentetrahydrofolate reductase (MTHFR) gene have been associated with myelomagenesis.	Folic Acid	45-51	methylenetetrahydrofolate reductase	Homo sapiens	91-125
16541270-1	2006	BACKGROUND: Low folate intake and changes in folate metabolism due to polymorphisms in the methylentetrahydrofolate reductase (MTHFR) gene have been associated with myelomagenesis.	Folic Acid	45-51	methylenetetrahydrofolate reductase	Homo sapiens	127-132
16541270-9	2006	CONCLUSIONS: Our data demonstrated that variant alleles did not play a key role neither in protection nor in increased risk for MM, suggesting that the effect of MTHFR on folate metabolism might be modified by diet intake.	Folic Acid	171-177	methylenetetrahydrofolate reductase	Homo sapiens	162-167
16410450-2	2006	Polymorphisms in genes encoding key enzymes controlling folate-methionine metabolism, including methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MS or MTR), serine hydroxymethyltransferase (SHMT), and thymidylate synthase (TS or TYMS), modify the risk of various cancers and possibly FL.	Folic Acid	56-62	methylenetetrahydrofolate reductase	Homo sapiens	133-138
16728583-0	2006	Folic acid and its metabolites modulate IGF-I receptor gene expression in colon cancer cells in a p53-dependent manner.	Folic Acid	0-10	insulin like growth factor 1 receptor	Homo sapiens	40-54
16728583-4	2006	The present study was aimed at testing the hypothesis that part of the modulatory effect of folic acid on malignant transformation may be attributed to its ability to regulate IGF-IR gene expression.	Folic Acid	92-102	insulin like growth factor 1 receptor	Homo sapiens	176-182
16728583-5	2006	Regulation of IGF-IR gene expression by folic acid was assessed using western blots, RT-PCR, transient transfections and chromatin immunoprecipitation assays.	Folic Acid	40-50	insulin like growth factor 1 receptor	Homo sapiens	14-20
16728583-7	2006	Results obtained showed that folic acid induced a dose-dependent decrease in IGF-IR protein and mRNA levels in the HCT116 +/+ colon cancer cell line.	Folic Acid	29-39	insulin like growth factor 1 receptor	Homo sapiens	77-83
16728583-11	2006	Moreover, folic acid induced a significant decrease in Sp1 binding to the IGF-IR promoter region.	Folic Acid	10-20	insulin like growth factor 1 receptor	Homo sapiens	74-80
16728583-13	2006	In conclusion, the mechanism of action of folic acid involves regulation of IGF-IR gene expression.	Folic Acid	42-52	insulin like growth factor 1 receptor	Homo sapiens	76-82
16714233-5	2006	Functional presence of a carrier-mediated transport system for folic acid (folate receptor alpha) was investigated on the basolateral side of the rabbit retina.	Folic Acid	63-73	folate receptor alpha	Oryctolagus cuniculus	75-96
16605249-11	2006	Folates have been shown to protect both human and bacterial enzymes from loss of FAD.	Folic Acid	0-7	BRCA2 DNA repair associated	Homo sapiens	81-84
16605249-17	2006	The direct interactions of bound folate with the cofactor provide one mechanism for linkage between binding of FAD and folate binding that could account in part for the protective action of folates.	Folic Acid	33-39	BRCA2 DNA repair associated	Homo sapiens	111-114
16605249-17	2006	The direct interactions of bound folate with the cofactor provide one mechanism for linkage between binding of FAD and folate binding that could account in part for the protective action of folates.	Folic Acid	119-125	BRCA2 DNA repair associated	Homo sapiens	111-114
16605249-17	2006	The direct interactions of bound folate with the cofactor provide one mechanism for linkage between binding of FAD and folate binding that could account in part for the protective action of folates.	Folic Acid	190-197	BRCA2 DNA repair associated	Homo sapiens	111-114
16518429-2	2006	A critical enzyme involved in folate metabolism is 5,10-methylenetetrahydrofolate reductase (MTHFR).	Folic Acid	30-36	methylenetetrahydrofolate reductase	Homo sapiens	51-91
16518429-2	2006	A critical enzyme involved in folate metabolism is 5,10-methylenetetrahydrofolate reductase (MTHFR).	Folic Acid	30-36	methylenetetrahydrofolate reductase	Homo sapiens	93-98
16365753-2	2006	The common germ-line mutation C677T in the MTHFR gene significantly diminishes specific activity of the enzyme, which is responsible for the circulating form of folate.	Folic Acid	161-167	methylenetetrahydrofolate reductase	Homo sapiens	43-48
16365753-7	2006	CONCLUSIONS: The obtained results suggest that the MTHFR mutation is a minor contributing factor in oncogenesis in the oral region, in conjunction with low dietary uptake of folate.	Folic Acid	174-180	methylenetetrahydrofolate reductase	Homo sapiens	51-56
16522921-2	2006	OBJECTIVE: We examined the interactions and associations with serum total homocysteine (tHcy) and folate concentrations of polymorphisms in the following folate-metabolizing genes: methylenetetrahydrofolate reductase (MTHFR), reduced folate carrier 1 (RFC1), and glutamate carboxypeptidase II (GCPII).	Folic Acid	154-160	methylenetetrahydrofolate reductase	Homo sapiens	181-216
16522921-5	2006	RESULTS: Subjects with the MTHFR 677TT genotype had higher serum tHcy concentrations than did those with the MTHFR 677CC genotype (P &lt; 0.001), and this effect was greater in subjects with low serum folate status (P for interaction = 0.026).	Folic Acid	201-207	methylenetetrahydrofolate reductase	Homo sapiens	27-32
16251475-8	2006	Pretreatment with an ERK1/2 blocker (PD-98059), staurosporine, folate, or NAC modulated Hcy-induced MMP-9 activation as measured using zymography.	Folic Acid	63-69	matrix metallopeptidase 9	Homo sapiens	100-105
16614955-1	2006	Inflammatory bowel disease (IBD) has been related to mutations of methylenetetrahydrofolate reductase (MTHFR), a critical enzyme in the metabolism of folate and methionine, both of which are important factors in DNA methylation and synthesis.	Folic Acid	85-91	methylenetetrahydrofolate reductase	Homo sapiens	103-108
16374229-1	2006	It has been proposed that folate and polymorphisms of the enzyme methylenetetrahydrofolate reductase (MTHFR), which regulates influx of folate from DNA synthesis and repair to methylation reactions, are involved in the aetiology of cancer.	Folic Acid	26-32	methylenetetrahydrofolate reductase	Homo sapiens	65-100
16374229-1	2006	It has been proposed that folate and polymorphisms of the enzyme methylenetetrahydrofolate reductase (MTHFR), which regulates influx of folate from DNA synthesis and repair to methylation reactions, are involved in the aetiology of cancer.	Folic Acid	26-32	methylenetetrahydrofolate reductase	Homo sapiens	102-107
16374229-1	2006	It has been proposed that folate and polymorphisms of the enzyme methylenetetrahydrofolate reductase (MTHFR), which regulates influx of folate from DNA synthesis and repair to methylation reactions, are involved in the aetiology of cancer.	Folic Acid	84-90	methylenetetrahydrofolate reductase	Homo sapiens	102-107
16374229-6	2006	Our previously reported observation of a possible increase in the risk of prostate cancer at high plasma folate levels was attributable in this study to subjects having the MTHFR 677C--&gt;T polymorphism.	Folic Acid	105-111	methylenetetrahydrofolate reductase	Homo sapiens	173-178
16374229-7	2006	We found that the MTHFR 677C--&gt;T polymorphism is not likely to have a major role in the development of prostate cancer, although it may possibly increase the risk in combination with high plasma folate levels.	Folic Acid	198-204	methylenetetrahydrofolate reductase	Homo sapiens	18-23
17163161-3	2006	In esophageal carcinomas, a higher gene expression of methylenetetrahydrofolate reductase (MTHFR), an enzyme involved in folate metabolism, was more frequently found in responding patients.	Folic Acid	73-79	methylenetetrahydrofolate reductase	Homo sapiens	91-96
16489479-3	2006	Two common polymorphisms (SNPs), C677T and A1298C, in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene involved in folate metabolism, are known to lower the activity of this enzyme.	Folic Acid	82-88	methylenetetrahydrofolate reductase	Homo sapiens	100-105
16225753-2	2005	METHODS: The plasma levels of homocysteine (Hcy), folate, and RANTES were measured in 38 control patients with normal Hcy levels and 40 patients with HHcy and the mRNA synthesis of RANTES in isolated human monocytes was determined by RNase protection assays.	Folic Acid	50-56	C-C motif chemokine ligand 5	Homo sapiens	181-187
22622501-6	2012	In AKI induced by ischemia reperfusion or folic acid, the loss of tubular beta-catenin substantially aggravated renal lesions.	Folic Acid	42-52	catenin (cadherin associated protein), beta 1	Mus musculus	74-86
22782530-10	2012	In conclusion, hyperhomocysteinaemia due to the MTHFR 677 C T polymorphism is associated with enhanced in vivo lipid peroxidation and platelet activation that are reversible, at least in part, following folic acid supplementation.	Folic Acid	203-213	methylenetetrahydrofolate reductase	Homo sapiens	48-53
22891343-10	2012	PPMO directed against T. gondii"s dihydrofolate reductase (DHFR), an enzyme necessary for folate synthesis, limited tachyzoite replication.	Folic Acid	41-47	dihydrofolate reductase	Mus musculus	59-63
22891343-11	2012	Rescue with exogenous folate demonstrated DHFR PPMO"s specificity.	Folic Acid	22-28	dihydrofolate reductase	Mus musculus	42-46
22695967-5	2012	Regression analyses of a cohort of 511 Czech controls not taking folate supplements revealed that only 2 variants in the MTHFR gene were associated with altered folate concentrations in plasma and/or erythrocytes.	Folic Acid	161-167	methylenetetrahydrofolate reductase	Homo sapiens	121-126
22695967-6	2012	In our previous study, we observed that the common variant MTHFR c.665C &gt; T (known as c.677C &gt; T; p.A222V) was associated with decreased plasma folate concentrations.	Folic Acid	150-156	methylenetetrahydrofolate reductase	Homo sapiens	59-64
22695967-7	2012	In the present study, we show in addition that the rare variant MTHFR c.1958C &gt; T (p.T653M) is associated with significantly increased erythrocyte folate concentrations (P = 0.02).	Folic Acid	150-156	methylenetetrahydrofolate reductase	Homo sapiens	64-69
22695967-8	2012	Multivariate regression analysis revealed that this uncommon variant, which is present in 2% of Czech control chromosomes, explains 0.9% of the total variability of erythrocyte folate concentrations; the magnitude of this effect size was comparable with that of the common MTHFR c.665C &gt; T variant.	Folic Acid	177-183	methylenetetrahydrofolate reductase	Homo sapiens	273-278
22230335-1	2012	OBJECTIVE: To evaluate the effects on anencephaly risk of the interaction between the maternal profile of folate, vitamin B12 and homocysteine and the 677C T polymorphism in the gene encoding methylenetetrahydrofolate reductase (MTHFR).	Folic Acid	106-112	methylenetetrahydrofolate reductase	Homo sapiens	192-227
22668858-1	2012	Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is involved in folate and homocysteine metabolism, and has been associated with geriatric disorders, including dementia and late-life depression.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
22648721-7	2012	The association between folic acid and reduced ASD risk was strongest for mothers and children with MTHFR 677 C&gt;T variant genotypes.	Folic Acid	24-34	methylenetetrahydrofolate reductase	Homo sapiens	100-105
22549734-11	2012	Overexpression of Dhfr, or oral administration of folic acid to improve dihydrofolate reductase (DHFR) function, recoupled eNOS in diabetes to improve endothelial function.	Folic Acid	50-60	dihydrofolate reductase	Mus musculus	72-95
22549734-11	2012	Overexpression of Dhfr, or oral administration of folic acid to improve dihydrofolate reductase (DHFR) function, recoupled eNOS in diabetes to improve endothelial function.	Folic Acid	50-60	dihydrofolate reductase	Mus musculus	97-101
22536880-2	2012	The methylenetetrahydrofolate reductase (MTHFR) gene is involved in folic acid metabolism and plays an essential role in inherited DNA methylation profiles.	Folic Acid	68-78	methylenetetrahydrofolate reductase	Homo sapiens	4-39
22536880-2	2012	The methylenetetrahydrofolate reductase (MTHFR) gene is involved in folic acid metabolism and plays an essential role in inherited DNA methylation profiles.	Folic Acid	68-78	methylenetetrahydrofolate reductase	Homo sapiens	41-46
22649255-1	2012	Genes functioning in folate-mediated 1-carbon metabolism are hypothesized to play a role in cardiovascular disease (CVD) risk beyond the current narrow focus on the MTHFR 677 C T (rs1801133) polymorphism.	Folic Acid	21-27	methylenetetrahydrofolate reductase	Homo sapiens	165-170
23056029-1	2012	BACKGROUND: Methylenetetrahydrofolate (MTHFR) enzyme plays an important role in folate metabolism which is involved in DNA methylation, repair, and synthesis.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	39-44
22377218-2	2012	Folate targeted polylactide-co-glycolide-polyethylene glycol-folic acid (PLGA-PEG-FA) nanoparticles containing 17-AAG were prepared and characterized.	Folic Acid	0-6	N-methylpurine DNA glycosylase	Homo sapiens	114-117
22377218-4	2012	The particle size of 17-AAG loaded folate targeted nanoparticles was 238.67+-3.52 nm, drug loading was 8.25+-2.49% and about 80% of drug was released from the nanoparticles over 10 days.	Folic Acid	35-41	N-methylpurine DNA glycosylase	Homo sapiens	24-27
22707272-3	2012	Evidence indicates that FB1 impairs folate metabolism.	Folic Acid	36-42	TCF3 fusion partner	Homo sapiens	24-27
21869730-1	2012	OBJECTIVES: To assess the influence of individual methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase A2756G polymorphisms on the change of serum folate concentration in response to different dosages and durations of folic acid (FA) supplementation in hypertensive Chinese adults.	Folic Acid	69-75	methylenetetrahydrofolate reductase	Homo sapiens	87-92
21869730-9	2012	CONCLUSION: We demonstrated that MTHFR C677T polymorphisms can not only affect serum folate levels at the baseline and post-FA treatment, but also therapeutic responses to various dosages and durations of FA supplementation.	Folic Acid	85-91	methylenetetrahydrofolate reductase	Homo sapiens	33-38
22397922-3	2012	The protecting amine group (Boc) was selectively deprotected and the latter targeted copolymer was produced through the reaction of this copolymer with activated folic acid.	Folic Acid	162-172	BOC cell adhesion associated, oncogene regulated	Homo sapiens	28-31
21986714-11	2012	Folic acid supplementation of the maternal diet was associated with reduced expression of PPARalpha, PPARgamma, and LXRalpha in the liver (P &lt; 0.001).	Folic Acid	0-10	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	101-110
21986714-17	2012	Furthermore, the expression of LXRalpha, PPARalpha, and PPARgamma in the liver and adipose tissue largely depends on the protein and folic acid content in the maternal diet during gestation.	Folic Acid	133-143	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	56-65
22147198-3	2012	Overexpression of GGH and downregulation of FPGS would be expected to decrease intracellular folate in its polyglutamylated form, thereby increasing efflux of folate and its related molecules, which might lead to resistance to drugs or folate deficiency.	Folic Acid	93-99	folylpolyglutamate synthase	Rattus norvegicus	44-48
22147198-3	2012	Overexpression of GGH and downregulation of FPGS would be expected to decrease intracellular folate in its polyglutamylated form, thereby increasing efflux of folate and its related molecules, which might lead to resistance to drugs or folate deficiency.	Folic Acid	159-165	folylpolyglutamate synthase	Rattus norvegicus	44-48
22147198-4	2012	The study was sought to delineate the activity of GGH and expression FPGS in tissues involved in folate homeostasis during alcoholism and the epigenetic regulation of these enzymes and transporters regulating intracellular folate levels.	Folic Acid	97-103	folylpolyglutamate synthase	Rattus norvegicus	69-73
22411217-3	2012	The C677T and A1298C variants of methylenetetrahydrofolate reductase gene (MTHFR) have been shown to influence folate and homocysteine metabolisms.	Folic Acid	52-58	methylenetetrahydrofolate reductase	Homo sapiens	75-80
22072423-4	2012	MCs take up folate, a vitamin necessary for cell proliferation, via the proton-coupled folate transporter (PCFT).	Folic Acid	12-18	solute carrier family 46, member 1	Mus musculus	107-111
22230384-1	2012	BACKGROUND: This study aimed to investigate if the homocysteine-lowering efficacy of two commonly used physiological doses (0.4 mg/d and 0.8 mg/d) of folic acid (FA) can be modified by individual methylenetetrahydrofolate reductase (MTHFR) C677T and/or methionine synthase (MTR) A2756G polymorphisms in hypertensive Chinese adults.	Folic Acid	150-160	methylenetetrahydrofolate reductase	Homo sapiens	196-231
22230384-1	2012	BACKGROUND: This study aimed to investigate if the homocysteine-lowering efficacy of two commonly used physiological doses (0.4 mg/d and 0.8 mg/d) of folic acid (FA) can be modified by individual methylenetetrahydrofolate reductase (MTHFR) C677T and/or methionine synthase (MTR) A2756G polymorphisms in hypertensive Chinese adults.	Folic Acid	150-160	methylenetetrahydrofolate reductase	Homo sapiens	233-238
22230384-1	2012	BACKGROUND: This study aimed to investigate if the homocysteine-lowering efficacy of two commonly used physiological doses (0.4 mg/d and 0.8 mg/d) of folic acid (FA) can be modified by individual methylenetetrahydrofolate reductase (MTHFR) C677T and/or methionine synthase (MTR) A2756G polymorphisms in hypertensive Chinese adults.	Folic Acid	150-160	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	253-272
23275280-1	2012	Methylenetetrahydrofolate reductase (MTHFR) enzyme is one of the most important enzymes with a pivotal role in the folate metabolism and DNA synthesis pathways.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
22776642-5	2012	NAT enzymes have had a role in important metabolic concepts: the identification of acetyl-CoA and endogenous metabolic roles in bacteria and in eukaryotic folate metabolism.	Folic Acid	155-161	bromodomain containing 2	Homo sapiens	0-3
22134951-0	2012	Dietary folate, but not choline, modifies neural tube defect risk in Shmt1 knockout mice.	Folic Acid	8-14	serine hydroxymethyltransferase 1 (soluble)	Mus musculus	69-74
22134951-2	2012	Mice with reduced Shmt1 expression exhibit a higher frequency of NTDs when placed on a folate- and choline-deficient diet and may represent a model of human NTDs.	Folic Acid	87-93	serine hydroxymethyltransferase 1 (soluble)	Mus musculus	18-23
21460376-1	2012	BACKGROUND: The association between dietary folate intake, two polymorphisms in methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TYMS), and survival in head and neck squamous cell carcinoma (HNSCC) patients is not clarified.	Folic Acid	44-50	methylenetetrahydrofolate reductase	Homo sapiens	117-122
22507617-5	2012	The relationships between MTHFR polymorphism and folate intake, serum folate or tHcy were investigated by dividing participants into CC, CT and TT types.	Folic Acid	49-55	methylenetetrahydrofolate reductase	Homo sapiens	26-31
22507617-8	2012	Therefore, MTHFR genotypes were proven to be a significant determinant for folate and tHcy concentrations.	Folic Acid	75-81	methylenetetrahydrofolate reductase	Homo sapiens	11-16
23244153-1	2012	AIM: The present case-control study was conducted to explore the association of MTHFR gene polymorphism and relations of P16, MGMT and HMLH1 to MTHFR and folate intake.	Folic Acid	154-160	methylenetetrahydrofolate reductase	Homo sapiens	80-85
23244153-7	2012	Similarly, patients with high intake of folate also showed a slight high risk of DNA methylation of MGMT, with OR (95% CI) of 2.03 (1.05-4.57).	Folic Acid	40-46	O-6-methylguanine-DNA methyltransferase	Homo sapiens	100-104
22524840-8	2012	Individuals with high folate intake and the MTHFR 677CC genotype showed a significant decreased risk of esophageal cancer (0.43, 0.25-0.89).	Folic Acid	22-28	methylenetetrahydrofolate reductase	Homo sapiens	44-49
22799306-9	2012	CONCLUSION: The MTHFR 677T allele is associated with a lower risk of colorectal cancer in Asian populations, and there is effect modification by population plasma folate.	Folic Acid	163-169	methylenetetrahydrofolate reductase	Homo sapiens	16-21
22799374-1	2012	OBJECTIVES: Since methylenetetrahydrofolate reductase (MTHFR) maintains the balance of circulating folate and methionine and blocks the formation of homocysteine, its regulation in relation to different cancers has extensively been studied in different populations.	Folic Acid	37-43	methylenetetrahydrofolate reductase	Homo sapiens	55-60
22799374-8	2012	These results for MTHFR polymorphism might be population specific in sporadic breast cancer affected patients but many other factors need to be excluded before making final conclusions including folate intake, population and disease heterogeneity.	Folic Acid	195-201	methylenetetrahydrofolate reductase	Homo sapiens	18-23
22901166-1	2012	OBJECTIVE: Methylenetetrahydrofolate reductase (MTHFR) catalyzes the metabolism of folate and nucleotides needed for DNA synthesis and repair.	Folic Acid	30-36	methylenetetrahydrofolate reductase	Homo sapiens	48-53
22901193-1	2012	BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the metabolism of folate, and the role of MTHFR C677T polymorphism in cervical carcinogenesis is still controversial.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	49-54
22901193-1	2012	BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the metabolism of folate, and the role of MTHFR C677T polymorphism in cervical carcinogenesis is still controversial.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	117-122
22901194-0	2012	Interactions between MTHFR C677T-A1298C variants and folic acid deficiency affect breast cancer risk in a Chinese population.	Folic Acid	53-63	methylenetetrahydrofolate reductase	Homo sapiens	21-26
22901194-1	2012	BACKGROUND: Our objective was to evaluate the MTHFR C677T-A1298C polymorphisms in patients with breast cancer and in individuals with no history of cancer, to compare the levels of genetic damage and apoptosis under folic acid (FA) deficiency between patients and controls, and to assess associations with breast cancer.	Folic Acid	216-226	methylenetetrahydrofolate reductase	Homo sapiens	46-51
22938427-1	2012	Methylenetetrahydrofolate reductase (MTHFR) is an essential enzyme involved in folate metabolism; a single nucleotide polymorphism (SNP) C677T has been reported to be linked with altered incidences of several diseases.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
23098468-1	2012	BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the metabolism of folate, and the role of the MTHFR C677T polymorphism in pancreatic carcinogenesis is still controversial.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	49-54
23098468-1	2012	BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the metabolism of folate, and the role of the MTHFR C677T polymorphism in pancreatic carcinogenesis is still controversial.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	121-126
21848426-1	2012	Two important polymorphisms of folate cycle enzymes, methylenetetrahydrofolate reductase (MTHFR) C677T and thymidylate synthase (TS) enhancer region (TSER) 28-bp tandem repeat, are related to risk of various types of cancer, including brain tumors, although there are few studies on this subject.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	53-88
21848426-1	2012	Two important polymorphisms of folate cycle enzymes, methylenetetrahydrofolate reductase (MTHFR) C677T and thymidylate synthase (TS) enhancer region (TSER) 28-bp tandem repeat, are related to risk of various types of cancer, including brain tumors, although there are few studies on this subject.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	90-95
22377700-5	2012	The polymorphisms MTHFR c.677C&gt;T and solute carrier family 19 (folate transporter), member 1 (SLC19A1) c.80 A&gt;G modulate folate concentrations, whereas the 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR) c.66A&gt;G polymorphism affects the MMA concentration.	Folic Acid	66-72	methylenetetrahydrofolate reductase	Homo sapiens	18-23
22377704-6	2012	The associations of the MTHFR C677T polymorphism with osteoporosis/osteopenia and femoral neck BMD suggest that these polymorphisms confer a risk of developing osteoporosis in patients with rheumatoid arthritis, a risk that may be reduced with folate and B complex supplementation.	Folic Acid	244-250	methylenetetrahydrofolate reductase	Homo sapiens	24-29
21878957-0	2012	Association of MTHFR and RFC1 gene polymorphism with hyperhomocysteinemia and its modulation by vitamin B12 and folic acid in an Indian population.	Folic Acid	112-122	methylenetetrahydrofolate reductase	Homo sapiens	15-20
21878957-0	2012	Association of MTHFR and RFC1 gene polymorphism with hyperhomocysteinemia and its modulation by vitamin B12 and folic acid in an Indian population.	Folic Acid	112-122	replication factor C subunit 1	Homo sapiens	25-29
22481900-4	2012	A recent inventory on folate in European food composition databases indicated that currently MA is more widely used than HPCL.	Folic Acid	22-28	2-hydroxyacyl-CoA lyase 1	Homo sapiens	121-125
21819229-3	2012	There is evidence to suggest that MTHFR C677T and A1298C polymorphisms alter the function of the enzyme, causing reduced folate and increased homocysteine levels in plasma.	Folic Acid	121-127	methylenetetrahydrofolate reductase	Homo sapiens	34-39
22083158-10	2012	Intriguingly, restoration of dihydrofolate reductase expression by oral administration of folic acid or overexpression of dihydrofolate reductase completely prevented AAA formation in Ang II-infused hph-1 mice while attenuating progressive uncoupling of eNOS.	Folic Acid	90-100	dihydrofolate reductase	Mus musculus	29-52
22083158-11	2012	Folic acid also attenuated vascular remodeling and inflammation characterized by medial elastin breakdown and augmented matrix metalloproteinase 2 activity and activation of matrix metalloproteinase 9, as well as macrophage infiltration.	Folic Acid	0-10	matrix metallopeptidase 2	Mus musculus	120-146
22605962-8	2012	Moreover, MTHFR 677CC carriers with higher folate intake showed a lower risk of death from ovarian cancer (HR = 0.32, 95% CI = 0.27-0.82).	Folic Acid	43-49	methylenetetrahydrofolate reductase	Homo sapiens	10-15
22277790-1	2012	BACKGROUND: Intracellular folate hemostasis depends on the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene.	Folic Acid	26-32	methylenetetrahydrofolate reductase	Homo sapiens	59-99
22277790-1	2012	BACKGROUND: Intracellular folate hemostasis depends on the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene.	Folic Acid	26-32	methylenetetrahydrofolate reductase	Homo sapiens	101-106
23090267-1	2012	OBJECTIVES: The methylenetetrahydrofolate reductase (MTHFR) enzyme activity plays an important role in the metabolism of folate within methionine-homocysteine pathway and, consequently, in the development of vascular diseases.	Folic Acid	35-41	methylenetetrahydrofolate reductase	Homo sapiens	53-58
23056169-1	2012	BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in folate metabolism and is involved in DNA methylation, DNA synthesis, and DNA repair.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	49-54
22457816-1	2012	The methylenetetrahydrofolate reductase (MTHFR) gene is one of the main regulatory enzymes involved in folate metabolism, DNA synthesis and remethylation reactions.	Folic Acid	23-29	methylenetetrahydrofolate reductase	Homo sapiens	41-46
22457816-8	2012	Further studies are necessary to determine the influence of the environment, especially the consumption of diet folate on sperm counts of men with different MTHFR variants.	Folic Acid	112-118	methylenetetrahydrofolate reductase	Homo sapiens	157-162
21451940-2	2011	Plasma Hcy is affected by 5,10-methylenetetrahydofolate reductase (MTHFR) genotype and dietary folate intake.	Folic Acid	49-55	methylenetetrahydrofolate reductase	Homo sapiens	67-72
21731042-0	2011	Increase in the prevalence of the MTHFR 677 TT polymorphism in women born since 1959: potential implications for folate requirements.	Folic Acid	113-119	methylenetetrahydrofolate reductase	Homo sapiens	34-39
21731042-1	2011	BACKGROUND/OBJECTIVES: Folate has been recognized to ensure reproductive health and there is a growing body of epidemiological evidence suggesting that the methylenetetrahydrofolate reductase (MTHFR) 677T allele and reduced dietary folate may increase the risk of cervical cancer.	Folic Acid	175-181	methylenetetrahydrofolate reductase	Homo sapiens	193-198
21920590-2	2011	Previous studies, in other clinical settings, have suggested that polymorphisms in key folate metabolising enzymes such as 5,10-methylenetetrahydrofolate reductase (MTHFR) influence both toxicity and efficacy of methotrexate.	Folic Acid	87-93	methylenetetrahydrofolate reductase	Homo sapiens	123-163
21920590-2	2011	Previous studies, in other clinical settings, have suggested that polymorphisms in key folate metabolising enzymes such as 5,10-methylenetetrahydrofolate reductase (MTHFR) influence both toxicity and efficacy of methotrexate.	Folic Acid	87-93	methylenetetrahydrofolate reductase	Homo sapiens	165-170
21873667-7	2011	Folate signaling appears to be unique for TAA at 1 week (Folh1, Cubn), whereas aryl-hydrocarbon receptor signaling might be important for both steroids at 1 month postinjection.	Folic Acid	0-6	cubilin (intrinsic factor-cobalamin receptor)	Mus musculus	64-68
22088060-0	2011	Spin-orbit and rotational couplings in radiative association of C(3P) and N(4S) atoms.	Folic Acid	74-79	spindlin 1	Homo sapiens	0-4
21967576-10	2011	Plasma folate level was inversely correlated with IBD risk associated with MTHFR C677T polymorphism (P=0.006).	Folic Acid	7-13	methylenetetrahydrofolate reductase	Homo sapiens	75-80
21967576-13	2011	Deficient folate status is associated with a higher impact of MTHFR C677T polymorphism on IBD risk.	Folic Acid	10-16	methylenetetrahydrofolate reductase	Homo sapiens	62-67
16055441-4	2005	By using the glycine auxotroph Chinese hamster ovary glyB cell line, which lacks a functional MFT and is deficient in folates transport into mitochondria, we showed by complementation that AtFOLT1 functions as a folate transporter in a hamster background.	Folic Acid	118-125	folate transporter 1	Arabidopsis thaliana	189-196
16055441-6	2005	Also, the expression of AtFOLT1 in Escherichia coli allows bacterial cells to uptake exogenous folate.	Folic Acid	95-101	folate transporter 1	Arabidopsis thaliana	24-31
16055441-8	2005	Also, the atfolt1 null mutant contains wild-type levels of folates in chloroplasts and preserves the enzymatic capacity to catalyze folate-dependent reactions in this subcellular compartment.	Folic Acid	59-65	folate transporter 1	Arabidopsis thaliana	10-17
16145688-1	2005	The enzyme, 5,10-methylenetetrahydrofolate reductase (MTHFR) plays a key role in cellular folate metabolism.	Folic Acid	36-42	methylenetetrahydrofolate reductase	Homo sapiens	54-59
16096989-1	2005	Stereoselectivity of the human reduced folate carrier (RFC1) was examined in Caco-2 cells using methotrexate (l-amethopterin or l-MTX) and its antipode (d-amethopterin or d-MTX) as model substrates.	Folic Acid	39-45	replication factor C subunit 1	Homo sapiens	55-59
16272757-1	2005	The genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) have been associated with increased toxicity of methotrexate (MTX), a folic acid antagonist that is widely used to treat cancer and immunosuppressive disorders such as rheumatoid arthritis.	Folic Acid	143-153	methylenetetrahydrofolate reductase	Homo sapiens	29-64
21334752-6	2011	We found negative correlations between Hsp70 levels and micronutrients including vitamin D, vitamin B12, as well as folate, which could be linked to the immune modulating effects of these vitamins.	Folic Acid	116-122	heat shock protein family A (Hsp70) member 4	Homo sapiens	39-44
21749215-2	2011	MTHFR deficiency is an autosomal recessive trait that could be a significant risk factor for a number of defects, for example, vascular events, due to lower dietary folate intake among South Indians.	Folic Acid	165-171	methylenetetrahydrofolate reductase	Homo sapiens	0-5
22024018-3	2011	Methylenetetrahydrofolate reductase (MTHFR) plays a crucial role in regulating folate metabolism, which affects both DNA synthesis/repair and methylation.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
21550412-4	2011	In addition to key roles in folate metabolism, dihydrofolate reductase (DHFR) can "recycle" BH2, and thus regenerate BH4.	Folic Acid	28-34	dihydrofolate reductase	Mus musculus	47-70
21550412-4	2011	In addition to key roles in folate metabolism, dihydrofolate reductase (DHFR) can "recycle" BH2, and thus regenerate BH4.	Folic Acid	28-34	dihydrofolate reductase	Mus musculus	72-76
21719790-5	2011	In the setting of acute kidney injury induced by folic acid, the blockade or absence of TWEAK abrogated the injury-related decrease in renal and plasma Klotho levels.	Folic Acid	49-59	klotho	Mus musculus	152-158
22022143-0	2011	Genetic interactions between MTHFR (C677T), methionine synthase (A2756G, C2758G) variants with vitamin B12 and folic acid determine susceptibility to premature coronary artery disease in Indian population.	Folic Acid	111-121	methylenetetrahydrofolate reductase	Homo sapiens	29-34
22022143-0	2011	Genetic interactions between MTHFR (C677T), methionine synthase (A2756G, C2758G) variants with vitamin B12 and folic acid determine susceptibility to premature coronary artery disease in Indian population.	Folic Acid	111-121	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	44-63
21210071-9	2011	In the mouse models, GNMT(tg) had increased hepatic folate significantly, whereas GNMT(ko) had reduced folate.	Folic Acid	52-58	glycine N-methyltransferase	Mus musculus	21-25
21210071-9	2011	In the mouse models, GNMT(tg) had increased hepatic folate significantly, whereas GNMT(ko) had reduced folate.	Folic Acid	103-109	glycine N-methyltransferase	Mus musculus	82-86
21482894-8	2011	Vitamin supplementation with folic acid (B(9)), pyridoxine hydrochloride (B(6)), and cyanocobalamin (B(12)) may result in healing of cutaneous ulcerations in some patients with MTHFR mutations.	Folic Acid	29-39	NADH:ubiquinone oxidoreductase subunit A3	Homo sapiens	41-45
21093223-3	2011	Methylenetetrahydrofolate reductase (MTHFR) is an essential enzyme in the folate mediated methylation transfer reactions.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
21334854-0	2011	Folate supplementation in schizophrenia: a possible role for MTHFR genotype.	Folic Acid	0-6	methylenetetrahydrofolate reductase	Homo sapiens	61-66
21334854-2	2011	This study examined the effect of folate supplementation on negative symptoms overall and in relation to MTHFR 677C&gt;T genotype.	Folic Acid	34-40	methylenetetrahydrofolate reductase	Homo sapiens	105-110
21334854-9	2011	In addition, MTHFR status significantly moderated the relationship between change in serum folate and change in negative symptoms: among participants with at least one copy of the T allele negative symptoms were more likely to improve with increased serum folate (p=0.03).	Folic Acid	91-97	methylenetetrahydrofolate reductase	Homo sapiens	13-18
21334854-9	2011	In addition, MTHFR status significantly moderated the relationship between change in serum folate and change in negative symptoms: among participants with at least one copy of the T allele negative symptoms were more likely to improve with increased serum folate (p=0.03).	Folic Acid	256-262	methylenetetrahydrofolate reductase	Homo sapiens	13-18
21334854-11	2011	However, a possible association between genotypes associated with reduced MTHFR activity and benefit from folate supplementation should be investigated further.	Folic Acid	106-112	methylenetetrahydrofolate reductase	Homo sapiens	74-79
21406397-0	2011	Shmt1 heterozygosity impairs folate-dependent thymidylate synthesis capacity and modifies risk of Apc(min)-mediated intestinal cancer risk.	Folic Acid	29-35	serine hydroxymethyltransferase 1 (soluble)	Mus musculus	0-5
21406397-3	2011	Cytoplasmic serine hydroxymethyltransferase (SHMT1) regulates the partitioning of folate-activated one-carbons between thymidylate and S-adenosylmethionine biosynthesis.	Folic Acid	82-88	serine hydroxymethyltransferase 1 (soluble)	Mus musculus	45-50
20978181-1	2011	OBJECTIVE: The human methylenetetrahydrofolate reductase (MTHFR) gene plays a crucial role in folate metabolism.	Folic Acid	40-46	methylenetetrahydrofolate reductase	Homo sapiens	58-63
21123458-0	2011	MTHFR C677T genotype influences the isotopic enrichment of one-carbon metabolites in folate-compromised men consuming d9-choline.	Folic Acid	85-91	methylenetetrahydrofolate reductase	Homo sapiens	0-5
21123458-1	2011	BACKGROUND: Homozygosity for the variant 677T allele in the methylenetetrahydrofolate reductase (MTHFR) gene increases the requirement for folate and may alter the metabolic use of choline.	Folic Acid	79-85	methylenetetrahydrofolate reductase	Homo sapiens	97-102
21050834-1	2011	BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) involves in folic acid metabolism which influences DNA methylation.	Folic Acid	68-78	methylenetetrahydrofolate reductase	Homo sapiens	12-47
21050834-1	2011	BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) involves in folic acid metabolism which influences DNA methylation.	Folic Acid	68-78	methylenetetrahydrofolate reductase	Homo sapiens	49-54
21178087-1	2011	The enzymes serine hydroxymethyltransferase 1 (gene name SHMT1) and methylenetetrahydrofolate reductase (gene name MTHFR) regulate key reactions in folate-mediated one-carbon metabolism.	Folic Acid	87-93	methylenetetrahydrofolate reductase	Homo sapiens	115-120
20177420-5	2011	Methylenetetrahydrofolate reductase (MTHFR) generates active folate necessary for haematopoiesis.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
21556118-1	2011	The reduced folate carrier (Rfc1; Slc19a1) mediated transport of reduced folates and antifolate drugs such as methotrexate (MTX) play an essential role in physiological folate homeostasis and MTX cancer chemotherapy.	Folic Acid	12-18	replication factor C subunit 1	Rattus norvegicus	28-32
21556118-1	2011	The reduced folate carrier (Rfc1; Slc19a1) mediated transport of reduced folates and antifolate drugs such as methotrexate (MTX) play an essential role in physiological folate homeostasis and MTX cancer chemotherapy.	Folic Acid	73-80	replication factor C subunit 1	Rattus norvegicus	28-32
21556118-1	2011	The reduced folate carrier (Rfc1; Slc19a1) mediated transport of reduced folates and antifolate drugs such as methotrexate (MTX) play an essential role in physiological folate homeostasis and MTX cancer chemotherapy.	Folic Acid	73-79	replication factor C subunit 1	Rattus norvegicus	28-32
21556118-10	2011	The predominant tissue distribution supports the essential role of Rfc1 in physiological folate homeostasis.	Folic Acid	89-95	replication factor C subunit 1	Rattus norvegicus	67-71
22296369-4	2011	The C677T variant lies in exon 4 at the folate binding site of the MTHFR gene and results in substitution of an alanine by a valine residue.	Folic Acid	40-46	methylenetetrahydrofolate reductase	Homo sapiens	67-72
21052817-1	2011	OBJECTIVE: We evaluated associations between folate, vitamin B12, and the methylenetetrahydrofolate reductase (MTHFR) gene, and risk of cervical intraepithelial neoplasia (CIN) and cervical cancer.	Folic Acid	45-51	methylenetetrahydrofolate reductase	Homo sapiens	111-116
21052817-5	2011	Low folate and the MTHFR 677 C &gt; T variant were associated with a higher risk for CIN2/3 and cervical cancer vs. wild-type or heterozygous genotypes with high folate [OR, 2.39 (1.18-4.85) and 3.19 (1.43-7.13)].	Folic Acid	162-168	methylenetetrahydrofolate reductase	Homo sapiens	19-24
21052817-7	2011	CONCLUSION: Serum folate concentration is inversely associated with the risk of cervical cancer, and the MTHFR variant genotype may increase CIN and cervical cancer risk in women with low folate or vitamin B12 status.	Folic Acid	188-194	methylenetetrahydrofolate reductase	Homo sapiens	105-110
20923444-1	2011	BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	49-54
21462086-7	2011	MTHFR 1298A&gt;C influenced folate in male CIMP+ risk (P interaction &lt; 0.01).	Folic Acid	28-34	methylenetetrahydrofolate reductase	Homo sapiens	0-5
21462086-8	2011	Our findings suggest folate supplementation effects may differ between genders, perhaps due to variation in MTHFR and/or endogenous/exogenous hormones, and may be important in the initiation and progression of methylated rectal tumors in men.	Folic Acid	21-27	methylenetetrahydrofolate reductase	Homo sapiens	108-113
22203923-14	2011	Further evaluation on larger series is mandatory since homocysteine activity (related to MTHFR activity) could be easily influenced by folate or cobalamin derivatives.	Folic Acid	135-141	methylenetetrahydrofolate reductase	Homo sapiens	89-94
21800644-2	2011	The authors represent more detailed information about the folate-related processes in human placenta, namely about the content of aminothiols at different allelic variants of placental methylenetetrahydrofolate reductase during the course of physiological pregnancy and preeclampsia.	Folic Acid	58-64	methylenetetrahydrofolate reductase	Homo sapiens	185-220
20421795-0	2010	Nutrigenetic impact of daily folate intake on plasma homocysteine and folate levels in patients with different methylenetetrahydrofolate reductase genotypes.	Folic Acid	29-35	methylenetetrahydrofolate reductase	Homo sapiens	111-146
20421795-3	2010	We examined the impact of daily intake of folate, a co-factor in homocysteine metabolism, on plasma homocysteine and folate levels in CAD patients in relation with MTHFR genotypes.	Folic Acid	42-48	methylenetetrahydrofolate reductase	Homo sapiens	164-169
20843827-0	2010	Functional interactions between the LRP6 WNT co-receptor and folate supplementation.	Folic Acid	61-67	low density lipoprotein receptor-related protein 6	Mus musculus	36-40
20843827-7	2010	Gene expression analysis in embryos and adults showed striking interactions between targeted Lrp6 deficiency and FA supplementation, especially for mitochondrial function, folate and methionine metabolism, WNT signaling and cytoskeletal regulation that together implicate relevant signaling and metabolic pathways supporting cell proliferation, morphology and differentiation.	Folic Acid	172-178	low density lipoprotein receptor-related protein 6	Mus musculus	93-97
20696177-12	2010	CONCLUSIONS: In HTs with isolated PFO and H-Hcys, oral folate supplementation reduces Hcys levels both in TT and CT subjects with C667 T mutation of MTHFR.	Folic Acid	55-61	methylenetetrahydrofolate reductase	Homo sapiens	149-154
21215183-11	2010	In folic acid deficient group, the expressions of tbx5 and nppa were reduced while the expressions of vmhc and amhc appeared normal.	Folic Acid	3-13	myosin heavy chain 7	Danio rerio	102-106
20890936-2	2010	The aim of this study was to determine the involvement of polymorphic variants in four genes (MTHFR, MTHFD1, MTR, and SLC19A1) that encode proteins related to folic acid metabolism in the women with susceptibility for having a child with NSCL/P.	Folic Acid	159-169	methylenetetrahydrofolate reductase	Homo sapiens	94-99
21180947-1	2010	UNLABELLED: Methylenetetrahydrofolate reductase gene (MTHFR) C677T polymorphism may be a risk factor for head and neck squamous cell carcinoma due to changes in folate levels that can induce disorders in the methylation pathway, which results in carcinogenesis.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	54-59
20721969-1	2010	Methylenetetrahydrofolate reductase (MTHFR) plays a central role in converting folate to a compound which serves as a methyl donor for DNA methylation, an epigenetic modification known to be dysregulated in carcinogenesis.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
20552676-2	2010	5,10-Methylenetetrahydrofolate reductase (MTHFR) is a crucial enzyme in folate-mediated one-carbon metabolism and folate deficiency can be associated with psychiatric symptoms.	Folic Acid	72-78	methylenetetrahydrofolate reductase	Homo sapiens	0-40
20552676-2	2010	5,10-Methylenetetrahydrofolate reductase (MTHFR) is a crucial enzyme in folate-mediated one-carbon metabolism and folate deficiency can be associated with psychiatric symptoms.	Folic Acid	72-78	methylenetetrahydrofolate reductase	Homo sapiens	42-47
20532609-9	2010	Subjects carrying the 5,10-methylenetetrahydrofolate reductase (MTHFR) CT or TT genotype had a lower DMA% and lower folate levels than those carrying the CC genotype.	Folic Acid	46-52	methylenetetrahydrofolate reductase	Homo sapiens	64-69
16272757-1	2005	The genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) have been associated with increased toxicity of methotrexate (MTX), a folic acid antagonist that is widely used to treat cancer and immunosuppressive disorders such as rheumatoid arthritis.	Folic Acid	143-153	methylenetetrahydrofolate reductase	Homo sapiens	66-71
16142417-1	2005	The functional polymorphism methionine synthase (MTR) c.2576A--&gt;G (D919G) influences homocysteine and folate metabolism and has been reported to be of protective function against oncological, neurodegenerative and vascular diseases.	Folic Acid	105-111	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	28-47
16177213-1	2005	5,10-Methylene-tetrahydrofolate reductase (MTHFR) is a key enzyme in folate-mediated 1-carbon metabolism.	Folic Acid	25-31	methylenetetrahydrofolate reductase	Homo sapiens	43-48
16363341-2	2005	Among the single nucleotide polymorphisms (SNPs) influencing the folate metabolism, the methylenetetrahydrofolate reductase (MTHFR) gene has been the one most exclusively studied.	Folic Acid	65-71	methylenetetrahydrofolate reductase	Homo sapiens	88-123
20671425-10	2010	These results suggested that maternal exposure to a low protein diet and folic acid during gestation alters gene expression of Igf2 and H19 in the liver by regulating the DNA methylation of these genes.	Folic Acid	73-83	insulin-like growth factor 2	Rattus norvegicus	127-131
20671425-10	2010	These results suggested that maternal exposure to a low protein diet and folic acid during gestation alters gene expression of Igf2 and H19 in the liver by regulating the DNA methylation of these genes.	Folic Acid	73-83	H19, imprinted maternally expressed transcript (non-protein coding)	Rattus norvegicus	136-139
20097536-0	2010	Effect of the methylenetetrahydrofolate reductase (MTHFR 677C&gt;T) polymorphism on plasma homocysteine concentrations in healthy children is influenced by consumption of folate-fortified foods.	Folic Acid	33-39	methylenetetrahydrofolate reductase	Homo sapiens	51-56
20097536-1	2010	OBJECTIVE: To explore the influence of folate-fortified foods (ready-to-eat [RTE] breakfast cereals or fruit-juice drinks) on the relation between the methylenetetrahydrofolate reductase (MTHFR 677C&gt;T) polymorphism and plasma total homocysteine (tHcy) concentrations in healthy children.	Folic Acid	39-45	methylenetetrahydrofolate reductase	Homo sapiens	151-186
20097536-1	2010	OBJECTIVE: To explore the influence of folate-fortified foods (ready-to-eat [RTE] breakfast cereals or fruit-juice drinks) on the relation between the methylenetetrahydrofolate reductase (MTHFR 677C&gt;T) polymorphism and plasma total homocysteine (tHcy) concentrations in healthy children.	Folic Acid	39-45	methylenetetrahydrofolate reductase	Homo sapiens	188-193
21070407-5	2010	However, polyglutamylated folates were still detectable, albeit at lower levels, in organelles isolated from the corresponding isozyme knockout lines, e.g. in plastids and mitochondria of the fpgs1 (plastidial) and fpgs2 (mitochondrial) mutants.	Folic Acid	26-33	DHFS-FPGS homolog B	Arabidopsis thaliana	192-197
20944139-2	2010	Methylene tetrahydrofolate reductase (MTHFR) plays an important role in folate metabolism and is also an important source of DNA methylation and DNA synthesis (nucleotide synthesis).	Folic Acid	20-26	methylenetetrahydrofolate reductase	Homo sapiens	38-43
21472308-2	2010	The enzymes 5,10-methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS) are essential participants in folic acid metabolism and DNA synthesis.	Folic Acid	121-131	methylenetetrahydrofolate reductase	Homo sapiens	12-52
21472308-2	2010	The enzymes 5,10-methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS) are essential participants in folic acid metabolism and DNA synthesis.	Folic Acid	121-131	methylenetetrahydrofolate reductase	Homo sapiens	54-59
20534379-0	2010	Alx3-deficient mice exhibit folic acid-resistant craniofacial midline and neural tube closure defects.	Folic Acid	28-38	aristaless-like homeobox 3	Mus musculus	0-4
20534379-4	2010	We report that folic acid is required in mouse embryos for the specific expression of the homeodomain gene Alx3 in the head mesenchyme, an important tissue for cranial neural tube closure.	Folic Acid	15-25	aristaless-like homeobox 3	Mus musculus	107-111
20534379-5	2010	Alx3-deficient mice exhibit increased failure of cranial neural tube closure and increased cell death in the craniofacial region, two effects that are also observed in wild type embryos developing in the absence of folic acid.	Folic Acid	215-225	aristaless-like homeobox 3	Mus musculus	0-4
20534379-6	2010	Folic acid cannot prevent these defects in Alx3-deficient embryos, indicating that one mechanism of folic acid action is through induced expression of Alx3.	Folic Acid	100-110	aristaless-like homeobox 3	Mus musculus	151-155
16363341-2	2005	Among the single nucleotide polymorphisms (SNPs) influencing the folate metabolism, the methylenetetrahydrofolate reductase (MTHFR) gene has been the one most exclusively studied.	Folic Acid	65-71	methylenetetrahydrofolate reductase	Homo sapiens	125-130
16126904-1	2005	A cranial neural tube defect in Crooked tail (Cd) mice is prevented with prenatal dietary folic acid Cd positional cloning reveals a missense mutation of a highly conserved amino acid in the low density lipoprotein receptor-related protein 6 (Lrp6), a coreceptor required for Wnt canonical signaling.	Folic Acid	90-100	low density lipoprotein receptor-related protein 6	Mus musculus	191-241
16126904-1	2005	A cranial neural tube defect in Crooked tail (Cd) mice is prevented with prenatal dietary folic acid Cd positional cloning reveals a missense mutation of a highly conserved amino acid in the low density lipoprotein receptor-related protein 6 (Lrp6), a coreceptor required for Wnt canonical signaling.	Folic Acid	90-100	low density lipoprotein receptor-related protein 6	Mus musculus	243-247
16095790-4	2005	Elevated homocysteine is often explained by folate dependency due to mutations in the gene for methylenetetrahydrofolate reductase (MTHFR).	Folic Acid	44-50	methylenetetrahydrofolate reductase	Homo sapiens	95-130
16095790-4	2005	Elevated homocysteine is often explained by folate dependency due to mutations in the gene for methylenetetrahydrofolate reductase (MTHFR).	Folic Acid	44-50	methylenetetrahydrofolate reductase	Homo sapiens	132-137
16109384-0	2005	The relationship between folate transport activity at low pH and reduced folate carrier function in human Huh7 hepatoma cells.	Folic Acid	25-31	MIR7-3 host gene	Homo sapiens	106-110
16109384-1	2005	Transport of folates and antifolates in both hepatocytes and Huh7 human hepatoma cells is characterized by a low-pH optimum.	Folic Acid	13-20	MIR7-3 host gene	Homo sapiens	61-65
16109384-7	2005	In Huh7 cells transiently transfected with an RFC siRNA, RFC expression was reduced by 60% resulting in a 40% decrease in MTX influx at pH 7.4 but only a very small (5%) reduction in MTX or folic acid influx at pH 5.5.	Folic Acid	190-200	MIR7-3 host gene	Homo sapiens	3-7
16086047-10	2005	CONCLUSION: Our findings indicate that the RFC1 genotype (GG) is a possible susceptible gene marker for an increased NTDs risk in this Chinese population, and there is a potential influence on the risk of NTDs in maternal periconceptional folic acid supplementation, and maternal fever during the early pregnancy.	Folic Acid	239-249	replication factor C subunit 1	Homo sapiens	43-47
16103455-1	2005	The 5,10-methylenetetrahydrofolate reductase (MTHFR) gene plays a critical role in folate metabolism.	Folic Acid	28-34	methylenetetrahydrofolate reductase	Homo sapiens	46-51
16103455-15	2005	Among those with adequate folate intake (&gt;400 microg total folate), we found strong inverse associations between combined MTHFR genotypes and MSI (677 CC+1298 AC/CC, OR, 0.09; 95% CI, 0.01-0.59; 677 CT/TT+1298 AA, OR, 0.13; 95% CI, 0.02-0.85) compared with the combined wild-type genotypes (677 CC+1298 AA).	Folic Acid	26-32	methylenetetrahydrofolate reductase	Homo sapiens	125-130
16103455-15	2005	Among those with adequate folate intake (&gt;400 microg total folate), we found strong inverse associations between combined MTHFR genotypes and MSI (677 CC+1298 AC/CC, OR, 0.09; 95% CI, 0.01-0.59; 677 CT/TT+1298 AA, OR, 0.13; 95% CI, 0.02-0.85) compared with the combined wild-type genotypes (677 CC+1298 AA).	Folic Acid	62-68	methylenetetrahydrofolate reductase	Homo sapiens	125-130
16103455-17	2005	Our results suggest that MTHFR variant genotypes are associated with reduced risk of MSI tumors under conditions of adequate folate intake, although the data are imprecise due to small numbers.	Folic Acid	125-131	methylenetetrahydrofolate reductase	Homo sapiens	25-30
16103455-18	2005	These results indicate that the relationship between MTHFR genotypes and MSI is influenced by folate status.	Folic Acid	94-100	methylenetetrahydrofolate reductase	Homo sapiens	53-58
15921520-1	2005	BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) has a major impact on the regulation of the folic acid pathway due to conversion of 5,10-methylenetetrahydrofolate (methylene-THF) to 5-methyl-THF.	Folic Acid	100-110	methylenetetrahydrofolate reductase	Homo sapiens	12-47
15921520-1	2005	BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) has a major impact on the regulation of the folic acid pathway due to conversion of 5,10-methylenetetrahydrofolate (methylene-THF) to 5-methyl-THF.	Folic Acid	100-110	methylenetetrahydrofolate reductase	Homo sapiens	49-54
15688408-1	2005	Folate deficiency is implicated in cancer risk that may be modulated by a genetic variation in the methylenetetrahydrofolate reductase (MTHFR) gene in folate metabolism.	Folic Acid	118-124	methylenetetrahydrofolate reductase	Homo sapiens	136-141
20635355-5	2010	We conducted a trial using two dietary supplements, betaine and folic acid to promote global levels of methylation and attempt to activate the paternally inherited UBE3A gene.	Folic Acid	64-74	ubiquitin protein ligase E3A	Homo sapiens	164-169
21044744-1	2010	BACKGROUND AND AIMS: The methylenetetrahydrofolate reductase (MTHFR) gene plays a key role in the metabolism of folate and homocysteine (Hcy) and its mutations have been associated with high serum Hcy level.	Folic Acid	44-50	methylenetetrahydrofolate reductase	Homo sapiens	62-67
20670473-9	2010	Our results confirmed that the MTHFR 677 C to T mutation, especially in lower serum folate concentration status, results in the increase of serum tHcy levels which is bad for cognitive function and indicates that higher serum folate level is of benefit in keeping lower serum tHcy level and better cognitive function.	Folic Acid	84-90	methylenetetrahydrofolate reductase	Homo sapiens	31-36
20670473-9	2010	Our results confirmed that the MTHFR 677 C to T mutation, especially in lower serum folate concentration status, results in the increase of serum tHcy levels which is bad for cognitive function and indicates that higher serum folate level is of benefit in keeping lower serum tHcy level and better cognitive function.	Folic Acid	226-232	methylenetetrahydrofolate reductase	Homo sapiens	31-36
20374270-1	2010	The methylenetetrahydrofolate reductase (MTHFR) encodes a major enzyme in folate metabolism.	Folic Acid	23-29	methylenetetrahydrofolate reductase	Homo sapiens	41-46
20411963-0	2010	Beta-lactoglobulin/folic acid complexes: formation, characterization, and biological implication.	Folic Acid	19-29	beta-lactoglobulin	Bos taurus	0-18
20219653-17	2010	The inhibitory results suggested that the N4-reduction might be catalyzed by aldehyde oxidase in the cytosol of pigs, and by aldehyde oxidase and xanthine oxidase in the cytosol of rats.	Folic Acid	42-44	aldehyde oxidase 1	Sus scrofa	77-93
20219653-17	2010	The inhibitory results suggested that the N4-reduction might be catalyzed by aldehyde oxidase in the cytosol of pigs, and by aldehyde oxidase and xanthine oxidase in the cytosol of rats.	Folic Acid	42-44	aldehyde oxidase 1	Sus scrofa	125-141
20447924-8	2010	However, in individuals with the lowest plasma folate concentrations, the MTHFR 677TT genotype showed a statistically nonsignificant increased CRC risk [RR (95% CI; Ptrend) TT versus CC=1.39 (0.87-2.21); 0.12], whereas those with the highest folate concentrations showed a nonsignificant decreased CRC risk [RR TT versus CC=0.74 (0.39-1.37); 0.34].	Folic Acid	242-248	methylenetetrahydrofolate reductase	Homo sapiens	74-79
20182861-0	2010	Folic acid administration reduces neointimal thickening, augments neo-vasa vasorum formation and reduces oxidative stress in saphenous vein grafts from pigs used as a model of diabetes.	Folic Acid	0-10	DEAD-box helicase 4	Sus scrofa	70-74
20182861-9	2010	CONCLUSIONS: Folic acid administration reduces neointimal thickening, augments vasa vasorum neoformation and reduces oxidative stress in saphenous vein grafts from diabetic pigs.	Folic Acid	13-23	DEAD-box helicase 4	Sus scrofa	79-83
20516537-1	2010	BACKGROUND &amp; OBJECTIVES: Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in folate metabolism and involved in DNA synthesis, DNA repair and DNA methylation.	Folic Acid	48-54	methylenetetrahydrofolate reductase	Homo sapiens	66-71
20412928-10	2010	The relative mRNA abundance of 5,10-methylene-tetrahydrofolate reductase and methylmalonyl-CoA mutase were increased by the combined injections of folic acid and vitamin B(12), whereas those of methionine synthase and methionine synthase reductase were not affected by treatments.	Folic Acid	147-157	methylmalonyl-CoA mutase	Bos taurus	77-101
20445408-1	2010	SUMMARY: Methylenetetrahydrofolate reductase (MTHFR) regulates the metabolism of folate and methionine, essential components of DNA synthesis and methylation.	Folic Acid	28-34	methylenetetrahydrofolate reductase	Homo sapiens	46-51
20404913-5	2010	In females, BDNF was positively correlated with BMI, fat mass, diastolic blood pressure, total cholesterol, and LDL-cholesterol, and inversely correlated with folate.	Folic Acid	159-165	brain derived neurotrophic factor	Homo sapiens	12-16
19968891-8	2010	Low serum folate was associated with smoking, low alcohol intake, high coffee intake, unhealthy diet, and the TT genotype of the methylenetetrahydrofolate reductase (MTHFR)-C677T polymorphism.	Folic Acid	10-16	methylenetetrahydrofolate reductase	Homo sapiens	129-164
19968891-8	2010	Low serum folate was associated with smoking, low alcohol intake, high coffee intake, unhealthy diet, and the TT genotype of the methylenetetrahydrofolate reductase (MTHFR)-C677T polymorphism.	Folic Acid	10-16	methylenetetrahydrofolate reductase	Homo sapiens	166-171
19846322-4	2010	This case-control study examines the potential association among hyperhomocysteinaemia (hyper-Hcy), low serum folate and vitamin B(12) levels and the common C677T mutation of the MTHFR gene in patients with AMVT.	Folic Acid	110-116	methylenetetrahydrofolate reductase	Homo sapiens	179-184
20035856-7	2010	We hypothesized that age-dependent Dnmt1 decreases synergize with low folate, low methionine or high homocysteine levels to demethylate and activate methylation-sensitive genes.	Folic Acid	70-76	DNA methyltransferase 1	Homo sapiens	35-40
20148291-0	2010	Basolateral efflux mediated by multidrug resistance-associated protein 3 (Mrp3/Abcc3) facilitates intestinal absorption of folates in mouse.	Folic Acid	123-130	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	Mus musculus	31-72
20148291-0	2010	Basolateral efflux mediated by multidrug resistance-associated protein 3 (Mrp3/Abcc3) facilitates intestinal absorption of folates in mouse.	Folic Acid	123-130	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	Mus musculus	74-78
20148291-0	2010	Basolateral efflux mediated by multidrug resistance-associated protein 3 (Mrp3/Abcc3) facilitates intestinal absorption of folates in mouse.	Folic Acid	123-130	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	Mus musculus	79-84
20148291-1	2010	PURPOSE: This study investigated the role of an ABC transporter, Mrp3/Abcc3 in intestinal folate absorption.	Folic Acid	90-96	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	Mus musculus	65-69
20148291-1	2010	PURPOSE: This study investigated the role of an ABC transporter, Mrp3/Abcc3 in intestinal folate absorption.	Folic Acid	90-96	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	Mus musculus	70-75
20148291-5	2010	RESULTS: C ( max ) and area-under plasma concentration-time curve of folic acid were 3.0- and 2.3-fold lower in Mrp3 ( -/- ) mice compared with wild-type mice, whereas the total body clearance was unchanged.	Folic Acid	69-79	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	Mus musculus	112-116
20148291-7	2010	Mucosal-to-serosal transport of folic acid and leucovorin was significantly decreased in the duodenum of Mrp3 ( -/- ) mice, where their PS ( serosal ) was decreased to 6.3 and 22% of that in wild-type mice, respectively.	Folic Acid	32-42	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	Mus musculus	105-109
20148291-10	2010	CONCLUSIONS: Mrp3 accounts for the serosal efflux of folic acid and leucovorin, while it makes a moderate contribution to the serosal efflux of 5-methyltetrahydrofolic acid in mice.	Folic Acid	53-63	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	Mus musculus	13-17
20083604-7	2010	The folate antagonist methotrexate (MTX) enters the cell via SLC19A1, and in the current study, MTX inclusion in bovine/ovine culture media at either 1 or 10 microM from the 1-cell stage inhibited embryo development beyond the 8-cell stage.	Folic Acid	4-10	solute carrier family 19 member 1	Bos taurus	61-68
19746410-1	2010	Different lines of evidence indicate that methylenetetrahydrofolate reductase (MTHFR) functional gene polymorphisms, causative in aberrant folate-homocysteine metabolism, are associated with increased vulnerability to several heritable developmental disorders.	Folic Acid	61-67	methylenetetrahydrofolate reductase	Homo sapiens	79-84
20193847-1	2010	Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the folate metabolic pathway.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
19669769-1	2010	BACKGROUND AND AIMS: The enzyme MTHFR plays an important role in folate metabolism, and folate is implicated in carcinogenesis due to its role in DNA methylation, repair, and synthesis.	Folic Acid	65-71	methylenetetrahydrofolate reductase	Homo sapiens	32-37
19577428-7	2010	High intakes of folate and vitamin B12 before diagnosis was associated with decreased gastric cancer mortality risk in susceptible MTHFR 677TT carriers (mortality risk for folate 0.14, 95% confidence interval 0.04-0.46, P for trend=0.001; mortality risk for vitamin B12 0.23, 95% confidence interval 0.08-0.66, P for trend=0.008).	Folic Acid	16-22	methylenetetrahydrofolate reductase	Homo sapiens	131-136
19577428-7	2010	High intakes of folate and vitamin B12 before diagnosis was associated with decreased gastric cancer mortality risk in susceptible MTHFR 677TT carriers (mortality risk for folate 0.14, 95% confidence interval 0.04-0.46, P for trend=0.001; mortality risk for vitamin B12 0.23, 95% confidence interval 0.08-0.66, P for trend=0.008).	Folic Acid	172-178	methylenetetrahydrofolate reductase	Homo sapiens	131-136
20467129-1	2010	Implantable fine needle-type glucose sensors with an outer diameter of less that 0.2 mm were fabricated using a low-cost and non-animal origin polyamide, gamma-polyglutamic acid (PGA) as a glucose oxidase (GOx) immobilizing material.	Folic Acid	179-182	hydroxyacid oxidase 1	Homo sapiens	189-204
20467129-1	2010	Implantable fine needle-type glucose sensors with an outer diameter of less that 0.2 mm were fabricated using a low-cost and non-animal origin polyamide, gamma-polyglutamic acid (PGA) as a glucose oxidase (GOx) immobilizing material.	Folic Acid	179-182	hydroxyacid oxidase 1	Homo sapiens	206-209
20467129-2	2010	Two types of PGA, gamma-polyglutamic acid (PGAH) and gamma-polyglutamic acid sodium salt (PGANa), were employed to prepare GOx immobilized film by the covalent attachment of GOx using water-soluble carbodiimide (EDC).	Folic Acid	13-16	hydroxyacid oxidase 1	Homo sapiens	123-126
20467129-2	2010	Two types of PGA, gamma-polyglutamic acid (PGAH) and gamma-polyglutamic acid sodium salt (PGANa), were employed to prepare GOx immobilized film by the covalent attachment of GOx using water-soluble carbodiimide (EDC).	Folic Acid	13-16	hydroxyacid oxidase 1	Homo sapiens	174-177
20467129-4	2010	The procedure of enzyme-immobilized film fabrication affected the stability of the sensor; that is, GOx immobilized film prepared by pouring a mixture solution of GOx and EDC on a PGA precoated surface showed higher sensor stability than that prepared by pouring a mixture solution of GOx, PGA and EDC.	Folic Acid	180-183	hydroxyacid oxidase 1	Homo sapiens	100-103
20467129-4	2010	The procedure of enzyme-immobilized film fabrication affected the stability of the sensor; that is, GOx immobilized film prepared by pouring a mixture solution of GOx and EDC on a PGA precoated surface showed higher sensor stability than that prepared by pouring a mixture solution of GOx, PGA and EDC.	Folic Acid	180-183	hydroxyacid oxidase 1	Homo sapiens	163-166
20467129-4	2010	The procedure of enzyme-immobilized film fabrication affected the stability of the sensor; that is, GOx immobilized film prepared by pouring a mixture solution of GOx and EDC on a PGA precoated surface showed higher sensor stability than that prepared by pouring a mixture solution of GOx, PGA and EDC.	Folic Acid	180-183	hydroxyacid oxidase 1	Homo sapiens	163-166
20467129-4	2010	The procedure of enzyme-immobilized film fabrication affected the stability of the sensor; that is, GOx immobilized film prepared by pouring a mixture solution of GOx and EDC on a PGA precoated surface showed higher sensor stability than that prepared by pouring a mixture solution of GOx, PGA and EDC.	Folic Acid	290-293	hydroxyacid oxidase 1	Homo sapiens	100-103
20467129-4	2010	The procedure of enzyme-immobilized film fabrication affected the stability of the sensor; that is, GOx immobilized film prepared by pouring a mixture solution of GOx and EDC on a PGA precoated surface showed higher sensor stability than that prepared by pouring a mixture solution of GOx, PGA and EDC.	Folic Acid	290-293	hydroxyacid oxidase 1	Homo sapiens	163-166
20467129-4	2010	The procedure of enzyme-immobilized film fabrication affected the stability of the sensor; that is, GOx immobilized film prepared by pouring a mixture solution of GOx and EDC on a PGA precoated surface showed higher sensor stability than that prepared by pouring a mixture solution of GOx, PGA and EDC.	Folic Acid	290-293	hydroxyacid oxidase 1	Homo sapiens	163-166
19923983-3	2010	MTHFR is central to folate metabolism and has two common functional polymorphisms (C677&gt;T and A1298&gt;C).	Folic Acid	20-26	methylenetetrahydrofolate reductase	Homo sapiens	0-5
20071789-1	2010	INTRODUCTION: Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in folate metabolism and is involved in DNA synthesis, DNA repair and DNA methylation.	Folic Acid	33-39	methylenetetrahydrofolate reductase	Homo sapiens	51-56
21173738-3	2010	Polymorphic genes involved in homocysteine and folate metabolism, including 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, are considered as an important risk factors for homocysteine accumulation and modulator of RM susceptibility.	Folic Acid	47-53	methylenetetrahydrofolate reductase	Homo sapiens	76-116
21173738-3	2010	Polymorphic genes involved in homocysteine and folate metabolism, including 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, are considered as an important risk factors for homocysteine accumulation and modulator of RM susceptibility.	Folic Acid	47-53	methylenetetrahydrofolate reductase	Homo sapiens	118-123
20661822-3	2010	Folate deficiency and functional polymorphisms in folate metabolizing genes such as methylene tetrahydrofolate reductase (MTHFR) 677C&gt;T may have oncogenic role through disruption of normal DNA methylation pattern, synthesis, and impaired DNA repair.	Folic Acid	50-56	methylenetetrahydrofolate reductase	Homo sapiens	84-120
20661822-3	2010	Folate deficiency and functional polymorphisms in folate metabolizing genes such as methylene tetrahydrofolate reductase (MTHFR) 677C&gt;T may have oncogenic role through disruption of normal DNA methylation pattern, synthesis, and impaired DNA repair.	Folic Acid	50-56	methylenetetrahydrofolate reductase	Homo sapiens	122-127
20237899-1	2010	Two common mutations, 677 C--&gt;T and a1298 A--&gt;C, in the methylenetetrahydrofolate reductase gene (MTHFR) reduce the activity of MTHFR and folate metabolism.	Folic Acid	81-87	methylenetetrahydrofolate reductase	Homo sapiens	104-109
20237899-1	2010	Two common mutations, 677 C--&gt;T and a1298 A--&gt;C, in the methylenetetrahydrofolate reductase gene (MTHFR) reduce the activity of MTHFR and folate metabolism.	Folic Acid	81-87	methylenetetrahydrofolate reductase	Homo sapiens	134-139
19917061-0	2009	[6S]-5-methyltetrahydrofolate increases plasma folate more effectively than folic acid in women with the homozygous or wild-type 677C--&gt;T polymorphism of methylenetetrahydrofolate reductase.	Folic Acid	23-29	methylenetetrahydrofolate reductase	Homo sapiens	157-192
19917061-0	2009	[6S]-5-methyltetrahydrofolate increases plasma folate more effectively than folic acid in women with the homozygous or wild-type 677C--&gt;T polymorphism of methylenetetrahydrofolate reductase.	Folic Acid	76-86	methylenetetrahydrofolate reductase	Homo sapiens	157-192
19963111-2	2009	Among these, the methylene tetrahydrofolate reductase gene (MTHFR) encodes an enzyme that converts folate to a methyl donor used for DNA methylation.	Folic Acid	37-43	methylenetetrahydrofolate reductase	Homo sapiens	60-65
19660467-0	2009	Mechanistic insights into folic acid-dependent vascular protection: dihydrofolate reductase (DHFR)-mediated reduction in oxidant stress in endothelial cells and angiotensin II-infused mice: a novel HPLC-based fluorescent assay for DHFR activity.	Folic Acid	26-36	dihydrofolate reductase	Mus musculus	68-91
19660467-0	2009	Mechanistic insights into folic acid-dependent vascular protection: dihydrofolate reductase (DHFR)-mediated reduction in oxidant stress in endothelial cells and angiotensin II-infused mice: a novel HPLC-based fluorescent assay for DHFR activity.	Folic Acid	26-36	dihydrofolate reductase	Mus musculus	93-97
19660467-0	2009	Mechanistic insights into folic acid-dependent vascular protection: dihydrofolate reductase (DHFR)-mediated reduction in oxidant stress in endothelial cells and angiotensin II-infused mice: a novel HPLC-based fluorescent assay for DHFR activity.	Folic Acid	26-36	dihydrofolate reductase	Mus musculus	231-235
19660467-3	2009	Expression of dihydrofolate reductase (DHFR) was markedly increased by folic acid (FA, 50 micromol/L, 24 h) treatment in endothelial cells.	Folic Acid	71-81	dihydrofolate reductase	Mus musculus	14-37
19660467-3	2009	Expression of dihydrofolate reductase (DHFR) was markedly increased by folic acid (FA, 50 micromol/L, 24 h) treatment in endothelial cells.	Folic Acid	71-81	dihydrofolate reductase	Mus musculus	39-43
15949101-2	2005	Folate pathways may be modified by polymorphisms in relevant genes, such as that for methylenetetrahydrofolate reductase (MTHFR), or by alcohol consumption.	Folic Acid	0-6	methylenetetrahydrofolate reductase	Homo sapiens	85-120
15949101-2	2005	Folate pathways may be modified by polymorphisms in relevant genes, such as that for methylenetetrahydrofolate reductase (MTHFR), or by alcohol consumption.	Folic Acid	0-6	methylenetetrahydrofolate reductase	Homo sapiens	122-127
15867278-8	2005	In conclusion, plasma total homocysteine concentrations in subjects with the MTHFR 677 T/T genotype were inversely related to 5-methyl folate concentrations and directly related to formylated folate concentrations in RBCs, even though the latter were not significantly affected by moderate folate restriction.	Folic Acid	135-141	methylenetetrahydrofolate reductase	Homo sapiens	77-82
15867278-8	2005	In conclusion, plasma total homocysteine concentrations in subjects with the MTHFR 677 T/T genotype were inversely related to 5-methyl folate concentrations and directly related to formylated folate concentrations in RBCs, even though the latter were not significantly affected by moderate folate restriction.	Folic Acid	192-198	methylenetetrahydrofolate reductase	Homo sapiens	77-82
15840047-8	2005	CONCLUSION: Higher folate concentrations in kidney transplant recipients with MTHFR 1793GA or 1793AA and markedly higher concentrations of vitamin B(12) in patients with combined MTHFR 1793G&gt;A and 1298A&gt;C mutations may contribute to the survival advantage that has been postulated for such patients showing these genotypes.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	78-83
19619620-8	2009	Pretreatment with folic acid prevented both the memory deficit and the reduction in the brain-derived neurotrophic factor immunocontent induced by homocysteine injection.	Folic Acid	18-28	brain-derived neurotrophic factor	Rattus norvegicus	88-121
19759169-0	2009	Increased breast cancer risk at high plasma folate concentrations among women with the MTHFR 677T allele.	Folic Acid	44-50	methylenetetrahydrofolate reductase	Homo sapiens	87-92
19759169-2	2009	OBJECTIVES: We examined plasma folate (P-folate) concentration in relation to genotypes of the folate-metabolizing enzyme methylenetetrahydrofolate reductase [MTHFR 677C--&gt;T (rs1801133) and 1298A--&gt;C (rs1801131)].	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	122-157
19759169-2	2009	OBJECTIVES: We examined plasma folate (P-folate) concentration in relation to genotypes of the folate-metabolizing enzyme methylenetetrahydrofolate reductase [MTHFR 677C--&gt;T (rs1801133) and 1298A--&gt;C (rs1801131)].	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	159-164
20146887-2	2009	Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
20009482-2	2009	Therefore, one may expect that the lower availability of substrate for biochemical reactions leads to more genetic changes in enzyme function; for example, most studies have indicated the variant MTHFR genotype 677TT is related to biomarkers, such as homocysteine concentrations or global DNA methylation particularly in a low folate diet.	Folic Acid	327-333	methylenetetrahydrofolate reductase	Homo sapiens	196-201
19943541-1	2009	5,10-methylenetetrahydrofolate reductase (MTHFR) is the key enzyme in folate, methionine and homocysteine metabolism.	Folic Acid	24-30	methylenetetrahydrofolate reductase	Homo sapiens	42-47
18498357-9	2009	Screening of risk factors for thromboembolism revealed that all patients carried a methylenetetrahydrofolate reductase 677C--&gt;T (MTHFR) mutation in a gene involved in folate metabolism, and either borderline or elevated homocysteine levels.	Folic Acid	102-108	methylenetetrahydrofolate reductase	Homo sapiens	132-137
18258338-1	2009	We examined polymorphisms in reduced folate carrier gene (RFC1) and methylenetetrahydrofolate reductase gene (MTHFR) for association with sporadic AD (SAD) in Chinese population.	Folic Acid	37-43	replication factor C subunit 1	Homo sapiens	58-62
19650776-2	2009	As folate transport across cell membranes is mediated in part by the reduced folate carrier (RFC1), variants within SLC19A1, the gene that encodes RFC1, may influence disease risk via an effect on folate and/or homocysteine levels.	Folic Acid	3-9	replication factor C subunit 1	Homo sapiens	93-97
19650776-2	2009	As folate transport across cell membranes is mediated in part by the reduced folate carrier (RFC1), variants within SLC19A1, the gene that encodes RFC1, may influence disease risk via an effect on folate and/or homocysteine levels.	Folic Acid	3-9	replication factor C subunit 1	Homo sapiens	147-151
19650776-2	2009	As folate transport across cell membranes is mediated in part by the reduced folate carrier (RFC1), variants within SLC19A1, the gene that encodes RFC1, may influence disease risk via an effect on folate and/or homocysteine levels.	Folic Acid	77-83	replication factor C subunit 1	Homo sapiens	93-97
19650776-2	2009	As folate transport across cell membranes is mediated in part by the reduced folate carrier (RFC1), variants within SLC19A1, the gene that encodes RFC1, may influence disease risk via an effect on folate and/or homocysteine levels.	Folic Acid	77-83	replication factor C subunit 1	Homo sapiens	147-151
19596833-2	2009	beta-AR agonists (salbutamol, a beta(2)-AR agonist; BRL 37344 and CGP 12177, beta(3)-AR agonists; adrenaline, a beta-AR agonist)-mediated lipolysis, beta(2)-, and beta(3)-ARs protein expression of the adipose tissues after folic acid consumption were evaluated.	Folic Acid	223-233	adrenergic receptor, beta 1	Mus musculus	0-7
20550866-5	2009	The C677T variant of the methylene-tetrahydrofolate reductase (MTHFR) gene is responsible of a thermolabile form, related to decrease of folate and increase homocysteine.	Folic Acid	45-51	methylenetetrahydrofolate reductase	Homo sapiens	63-68
19657138-2	2009	The main regulating enzymes in folate and homocysteine metabolism are methylenetetrahydrofolate reductase (MTHFR) and cystathionine beta-synthase (CBS).	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	70-105
19657138-2	2009	The main regulating enzymes in folate and homocysteine metabolism are methylenetetrahydrofolate reductase (MTHFR) and cystathionine beta-synthase (CBS).	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	107-112
20021850-12	2009	The interaction analysis suggested that the low level of folacin intakes and the MTHFR 677TT genotype had a positive adding effect in the occurring of congenital heart disease.	Folic Acid	57-64	methylenetetrahydrofolate reductase	Homo sapiens	81-86
20021850-16	2009	There is interaction between folacin intakes and the MTHFR 677TT genotype.	Folic Acid	29-36	methylenetetrahydrofolate reductase	Homo sapiens	53-58
20021850-17	2009	Increasing the intakes of folacin among MTHFR 677TT genotype people might decrease the incidence rate of congenital heart disease.	Folic Acid	26-33	methylenetetrahydrofolate reductase	Homo sapiens	40-45
19152916-0	2009	The up-regulation of monocyte chemoattractant protein-1 (MCP-1) in Ea.hy 926 endothelial cells under long-term low folate stress is mediated by the p38 MAPK pathway.	Folic Acid	115-121	chemokine (C-C motif) ligand 2	Mus musculus	21-55
19152916-0	2009	The up-regulation of monocyte chemoattractant protein-1 (MCP-1) in Ea.hy 926 endothelial cells under long-term low folate stress is mediated by the p38 MAPK pathway.	Folic Acid	115-121	chemokine (C-C motif) ligand 2	Mus musculus	57-62
19578646-2	2009	Methylenetetrahydrofolate reductase (MTHFR) is involved in folate metabolism and several polymorphisms have been described in the MTHFR gene.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
19578646-2	2009	Methylenetetrahydrofolate reductase (MTHFR) is involved in folate metabolism and several polymorphisms have been described in the MTHFR gene.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	130-135
19722341-7	2009	RESULTS: The analyzed folate content of foods was, on average, 151% +/- 63 of the CNF values.	Folic Acid	22-28	NPHS1 adhesion molecule, nephrin	Homo sapiens	82-85
19557016-1	2009	To evaluate the relationship between dietary folate intake and genetic polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR) with reference to breast cancer risk, we conducted a case-control study with 669 cases and 682 population-based controls in the Jiangsu Province of China.	Folic Acid	45-51	methylenetetrahydrofolate reductase	Homo sapiens	88-128
19557016-1	2009	To evaluate the relationship between dietary folate intake and genetic polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR) with reference to breast cancer risk, we conducted a case-control study with 669 cases and 682 population-based controls in the Jiangsu Province of China.	Folic Acid	45-51	methylenetetrahydrofolate reductase	Homo sapiens	130-135
19557016-11	2009	Among individuals with the MTHFR A1298C A/A genotype, adjusted ORs for breast cancer were 0.89 (0.62-1.27) and 1.69 (1.20-2.36) for the second to the third tertile of folate intake compared with the highest folate intake group (tread test, P=0.0008).	Folic Acid	167-173	methylenetetrahydrofolate reductase	Homo sapiens	27-32
19557016-11	2009	Among individuals with the MTHFR A1298C A/A genotype, adjusted ORs for breast cancer were 0.89 (0.62-1.27) and 1.69 (1.20-2.36) for the second to the third tertile of folate intake compared with the highest folate intake group (tread test, P=0.0008).	Folic Acid	207-213	methylenetetrahydrofolate reductase	Homo sapiens	27-32
20387639-6	2009	We have estimated the level of folate, components of methionine cycle--methionine and homocysteine, and related with methionine cycle cysteine and glutathione and polymorphism of methylentetrahydrofolate reductase (MTHFR) catalyzes the irreversible conversion of 5,10-methyl-enetetrahydrofolate to 5-methyltetrahydrofolate, which serves as supplier of methyl group for methionine cycle.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	179-213
20387639-6	2009	We have estimated the level of folate, components of methionine cycle--methionine and homocysteine, and related with methionine cycle cysteine and glutathione and polymorphism of methylentetrahydrofolate reductase (MTHFR) catalyzes the irreversible conversion of 5,10-methyl-enetetrahydrofolate to 5-methyltetrahydrofolate, which serves as supplier of methyl group for methionine cycle.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	215-220
20387639-8	2009	In the samples-carriers of C/T genotype of MTHFR and in the group with complicated pregnancies the content of aminothiols and folates correlate in different directions with homocysteine level which serves as a marker of folate-dependent methionine cycle and related processes.	Folic Acid	126-133	methylenetetrahydrofolate reductase	Homo sapiens	43-48
20387639-8	2009	In the samples-carriers of C/T genotype of MTHFR and in the group with complicated pregnancies the content of aminothiols and folates correlate in different directions with homocysteine level which serves as a marker of folate-dependent methionine cycle and related processes.	Folic Acid	126-132	methylenetetrahydrofolate reductase	Homo sapiens	43-48
19451595-6	2009	Finally, we show that the folate-induced DNA methylation limits proliferation and increases the sensitivity to temozolomide-induced apoptosis in glioma cells through methylation of the genes implicated in these processes (PDGF-B, MGMT, survivin, and bcl-w).	Folic Acid	26-32	platelet derived growth factor subunit B	Homo sapiens	222-228
19451595-6	2009	Finally, we show that the folate-induced DNA methylation limits proliferation and increases the sensitivity to temozolomide-induced apoptosis in glioma cells through methylation of the genes implicated in these processes (PDGF-B, MGMT, survivin, and bcl-w).	Folic Acid	26-32	O-6-methylguanine-DNA methyltransferase	Homo sapiens	230-234
19487547-1	2009	The 5,10-methyl-tetrahydrofolate reductase (MTHFR) enzyme plays a critical role in folate and homocysteine metabolism, and its gene, MTHFR, displays common genetic polymorphisms that influence its activity.	Folic Acid	26-32	methylenetetrahydrofolate reductase	Homo sapiens	44-49
19487547-1	2009	The 5,10-methyl-tetrahydrofolate reductase (MTHFR) enzyme plays a critical role in folate and homocysteine metabolism, and its gene, MTHFR, displays common genetic polymorphisms that influence its activity.	Folic Acid	26-32	methylenetetrahydrofolate reductase	Homo sapiens	133-138
19604445-1	2009	OBJECTIVE: MTHFR is an enzyme involved in the folate pathway.	Folic Acid	46-52	methylenetetrahydrofolate reductase	Homo sapiens	11-16
20680153-1	2009	BACKGROUND: The 5,10-methylenetetrahydrofolate reductase (MTHFR) polymorphisms and low folate levels are associated with inhibition of DNA methyltransferase and consequently DNA hypomethylation.	Folic Acid	40-46	methylenetetrahydrofolate reductase	Homo sapiens	58-63
19123462-4	2009	In HCT116 cells, the MTHFR 677T mutation was associated with significantly increased genomic DNA methylation when folate supply was adequate or high; however, in the setting of folate insufficiency, this mutation was associated with significantly decreased genomic DNA methylation.	Folic Acid	114-120	methylenetetrahydrofolate reductase	Homo sapiens	21-26
19123462-4	2009	In HCT116 cells, the MTHFR 677T mutation was associated with significantly increased genomic DNA methylation when folate supply was adequate or high; however, in the setting of folate insufficiency, this mutation was associated with significantly decreased genomic DNA methylation.	Folic Acid	177-183	methylenetetrahydrofolate reductase	Homo sapiens	21-26
19123462-5	2009	In contrast, in MDA-MB-435 cells, the MTHFR 677T mutation was associated with significantly decreased genomic DNA methylation when folate supply was adequate or high and with no effect when folate supply was low.	Folic Acid	131-137	methylenetetrahydrofolate reductase	Homo sapiens	38-43
19123462-5	2009	In contrast, in MDA-MB-435 cells, the MTHFR 677T mutation was associated with significantly decreased genomic DNA methylation when folate supply was adequate or high and with no effect when folate supply was low.	Folic Acid	190-196	methylenetetrahydrofolate reductase	Homo sapiens	38-43
19225123-0	2009	Does the MTHFR 677C--&gt;T variant affect the Recommended Dietary Allowance for folate in the US population?	Folic Acid	80-86	methylenetetrahydrofolate reductase	Homo sapiens	9-14
19225123-1	2009	BACKGROUND: The MTHFR 677C--&gt;T variant is associated with reduced enzyme activity, abnormalities of folate metabolism, and potential increase in folate requirement.	Folic Acid	103-109	methylenetetrahydrofolate reductase	Homo sapiens	16-21
19225123-1	2009	BACKGROUND: The MTHFR 677C--&gt;T variant is associated with reduced enzyme activity, abnormalities of folate metabolism, and potential increase in folate requirement.	Folic Acid	148-154	methylenetetrahydrofolate reductase	Homo sapiens	16-21
18782461-3	2009	We therefore investigated haem and folate transport characteristics of PCFT/HCP1 both in vivo and in vitro in CD-1 mice and in the presence or absence of a blocking antibody for PCFT/HCP1, and also in cultured cells (which express PCFT/HCP1 endogenously) to elucidate the specificity and selectivity of PCFT/HCP1.	Folic Acid	35-41	solute carrier family 46, member 1	Mus musculus	71-80
18782461-7	2009	Both haem and folate uptake were significantly (P &lt; 0.05) reduced in cells transfected with PCFT/HCP1 siRNA; however, the magnitude of reduction with folic acid uptake was greater (48 %) than that of haem (22.5 %).	Folic Acid	14-20	solute carrier family 46, member 1	Mus musculus	95-104
18782461-7	2009	Both haem and folate uptake were significantly (P &lt; 0.05) reduced in cells transfected with PCFT/HCP1 siRNA; however, the magnitude of reduction with folic acid uptake was greater (48 %) than that of haem (22.5 %).	Folic Acid	153-163	solute carrier family 46, member 1	Mus musculus	95-104
18782461-9	2009	PCFT/HCP1 could therefore play a physiological role in Fe nutrition and the data highlight the potential for the interaction of folate and haem at the level of intestinal absorption.	Folic Acid	128-134	solute carrier family 46, member 1	Mus musculus	0-9
19117321-4	2009	Among responsive mutants, folic acid supplementation reduces exencephaly and/or spina bifida aperta frequency in the Sp(2H), Sp, Cd, Cited2, Cart1, and Gcn5 mutants.	Folic Acid	26-36	ALX homeobox 1	Mus musculus	141-146
19117321-4	2009	Among responsive mutants, folic acid supplementation reduces exencephaly and/or spina bifida aperta frequency in the Sp(2H), Sp, Cd, Cited2, Cart1, and Gcn5 mutants.	Folic Acid	26-36	K(lysine) acetyltransferase 2A	Mus musculus	152-156
19336565-1	2009	BACKGROUND: Single nucleotide polymorphisms (SNP) of the folate-metabolizing enzyme methylenetetrahydrofolate reductase (MTHFR) may modify associations between folate intake and breast cancer.	Folic Acid	57-63	methylenetetrahydrofolate reductase	Homo sapiens	84-119
19336565-1	2009	BACKGROUND: Single nucleotide polymorphisms (SNP) of the folate-metabolizing enzyme methylenetetrahydrofolate reductase (MTHFR) may modify associations between folate intake and breast cancer.	Folic Acid	57-63	methylenetetrahydrofolate reductase	Homo sapiens	121-126
18602821-4	2009	Bivariate analysis showed that folate deficiency (0.3 nmol/L of folate vs. 2.27 mumol/L in control medium) displayed rapid and coordinated regulation during the first 2 h with differential expression for hRfc1 (increased by 69%) and Ahcy (decreased by 437%).	Folic Acid	31-37	replication factor C subunit 1	Homo sapiens	204-209
18602821-4	2009	Bivariate analysis showed that folate deficiency (0.3 nmol/L of folate vs. 2.27 mumol/L in control medium) displayed rapid and coordinated regulation during the first 2 h with differential expression for hRfc1 (increased by 69%) and Ahcy (decreased by 437%).	Folic Acid	64-70	replication factor C subunit 1	Homo sapiens	204-209
19136566-3	2009	In so doing, it has been determined that heterologously expressed AtMRP1 and its equivalents in red beet vacuolar membranes are not only competent in the transport of glutathione conjugates but also folate monoglutamates and antifolates as exemplified by pteroyl-l-glutamic acid and methotrexate (MTX), respectively.	Folic Acid	255-278	multidrug resistance-associated protein 1	Arabidopsis thaliana	66-72
19136566-7	2009	AtMRP1 and its counterparts in other plant species therefore have the potential for participating in the vacuolar accumulation of folates and related compounds.	Folic Acid	130-137	multidrug resistance-associated protein 1	Arabidopsis thaliana	0-6
19033540-1	2009	In humans and pigs, hydrolysis of dietary polyglutamyl folates is carried out by intestinal brush border folate hydrolase [glutamate carboxypeptidase II (GCPII)], whereas the transport of the monoglutamyl folate derivatives occurs via the intestinal brush border reduced folate carrier (RFC).	Folic Acid	55-61	glutamate carboxypeptidase 2	Sus scrofa	123-152
19033540-1	2009	In humans and pigs, hydrolysis of dietary polyglutamyl folates is carried out by intestinal brush border folate hydrolase [glutamate carboxypeptidase II (GCPII)], whereas the transport of the monoglutamyl folate derivatives occurs via the intestinal brush border reduced folate carrier (RFC).	Folic Acid	55-61	glutamate carboxypeptidase 2	Sus scrofa	154-159
19033540-2	2009	The study objective was to measure the expression of intestinal GCPII and RFC during postnatal development of pigs and their effects on plasma and liver folate concentrations.	Folic Acid	153-159	glutamate carboxypeptidase 2	Sus scrofa	64-69
19033540-9	2009	These findings show that intestinal GCPII and intestinal and hepatic RFC all exhibit ontogenic changes in the pig that are reflected in postnatal folate status.	Folic Acid	146-152	glutamate carboxypeptidase 2	Sus scrofa	36-41
19135973-4	2009	We proved that CB 3717/folate-induced ODC expression is Akt-dependent.	Folic Acid	23-29	ornithine decarboxylase, structural 1	Mus musculus	38-41
19161160-7	2009	RESULTS: A polymorphism in CUBN was significantly associated with decreased spina bifida risk, after correction for multiple testing, and was related to increased vitamin B(12) (p = 0.039) and red blood cell folate (p = 0.001).	Folic Acid	208-214	cubilin	Homo sapiens	27-31
19121630-4	2009	Methylenetetrahydrofolate reductase (MTHFR) regulates intracellular folate metabolism.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
19124508-0	2009	Methionine synthase A2756G polymorphism interacts with alcohol and folate intake to influence the risk of colorectal adenoma.	Folic Acid	67-73	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	0-19
19588544-4	2009	Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MTR) are enzymes that play central roles in the folate metabolic pathway.	Folic Acid	19-25	probable methylenetetrahydrofolate reductase	Nicotiana tabacum	37-42
20075510-4	2009	To investigate the relationship between folate metabolism and Down syndrome (DS) in a Danish population, we analyzed the common 677C&gt;T genetic polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene.	Folic Acid	40-46	methylenetetrahydrofolate reductase	Homo sapiens	203-208
19421414-4	2009	METHODS: Methylenetetrahydrofolate reductase (MTHFR) catalyzes a critical step in folate metabolism, and genetic variation in MTHFR has been associated with several late-onset neurodegenerative diseases.	Folic Acid	28-34	methylenetetrahydrofolate reductase	Homo sapiens	46-51
19421414-4	2009	METHODS: Methylenetetrahydrofolate reductase (MTHFR) catalyzes a critical step in folate metabolism, and genetic variation in MTHFR has been associated with several late-onset neurodegenerative diseases.	Folic Acid	28-34	methylenetetrahydrofolate reductase	Homo sapiens	126-131
20066895-12	2009	Our study corroborates previous findings of an inverse association of the MTHFR 677TT genotype with colorectal cancer, in particular at high levels of folate.	Folic Acid	151-157	methylenetetrahydrofolate reductase	Homo sapiens	74-79
19180309-1	2009	OBJECTIVE: To asses the association between intake of folate and B vitamins and the incidence of spontaneous abortion (SA) according to the maternal methylenetetrahydrofolate reductase (MTHFR) polymorphisms (677 C&gt;T and 1298 A&gt;C).	Folic Acid	54-60	methylenetetrahydrofolate reductase	Homo sapiens	186-191
18351371-2	2008	Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MS) are critical enzymes of folate metabolic pathways.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
18351371-2	2008	Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MS) are critical enzymes of folate metabolic pathways.	Folic Acid	19-25	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	69-71
19133595-3	2008	Furthermore, genetic polymorphisms of the methylenetetrahydrofolate reductase gene can elevate the risk of congenital defects, particularly in children of mothers with low levels of folic acid.	Folic Acid	182-192	methylenetetrahydrofolate reductase	Homo sapiens	42-77
19133595-4	2008	To allow a sufficient supply with folic acid for persons with reduced enzymatic activity of the methylenetetrahydrofolate reductase, a supplementation with a combination of folic acid and 5-methyltetrahydrofolate can be performed.	Folic Acid	34-44	methylenetetrahydrofolate reductase	Homo sapiens	96-131
19133595-4	2008	To allow a sufficient supply with folic acid for persons with reduced enzymatic activity of the methylenetetrahydrofolate reductase, a supplementation with a combination of folic acid and 5-methyltetrahydrofolate can be performed.	Folic Acid	173-183	methylenetetrahydrofolate reductase	Homo sapiens	96-131
19803295-3	2008	It has been hypothesized that the maternal folic acid supplementation prevents NTDs by partially correcting reduced MTHFR activity associated with the variant form of the enzyme.	Folic Acid	43-53	methylenetetrahydrofolate reductase	Homo sapiens	116-121
19256756-1	2008	BACKGROUND: It has been proposed that folate and polymorphisms of the enzyme methylenetetrahydrofolate reductase (MTHFR), which regulates influx of folate for methylation reactions for DNA synthesis and repair, are involved in colorectal cancer.	Folic Acid	38-44	methylenetetrahydrofolate reductase	Homo sapiens	77-112
19256756-1	2008	BACKGROUND: It has been proposed that folate and polymorphisms of the enzyme methylenetetrahydrofolate reductase (MTHFR), which regulates influx of folate for methylation reactions for DNA synthesis and repair, are involved in colorectal cancer.	Folic Acid	38-44	methylenetetrahydrofolate reductase	Homo sapiens	114-119
19256756-1	2008	BACKGROUND: It has been proposed that folate and polymorphisms of the enzyme methylenetetrahydrofolate reductase (MTHFR), which regulates influx of folate for methylation reactions for DNA synthesis and repair, are involved in colorectal cancer.	Folic Acid	96-102	methylenetetrahydrofolate reductase	Homo sapiens	114-119
19256756-7	2008	Furthermore, a significant reduction in recurrence risk was seen in MTHFR G1793A heterozygotes limited to those who received folate supplements.	Folic Acid	125-131	methylenetetrahydrofolate reductase	Homo sapiens	68-73
18714187-1	2008	Genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) gene are thought to have significant effects on folate metabolism and, thus, on cancer risk, but the reported results are not always consistent.	Folic Acid	44-50	methylenetetrahydrofolate reductase	Homo sapiens	62-67
18650265-6	2008	Studies with native mouse intestine showed a significantly higher folate uptake in villus compared with crypt cells, which was again associated with a significantly higher level of expression of the mouse RFC and PCFT at the protein and mRNA levels.	Folic Acid	66-72	solute carrier family 46, member 1	Mus musculus	213-217
17896178-2	2008	Based on the hypothesis that variants of the cSHMT C1420T together with methionine synthase (MS A2756G) and 5,10-methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) are associated with breast cancer, we performed a multigenic case-control study of the effects to breast cancer risk of four polymorphisms of folate-metabolizing genes against duration of estrogen exposure.	Folic Acid	132-138	methylenetetrahydrofolate reductase	Homo sapiens	150-155
18514430-8	2008	A particular polymorphic form to a key enzyme required to activate folate for methylation in neurodevelopment, 5-methylenetetrahydrofolate reductase (MTHFR), demonstrates reduced activity under low or normal folate levels but normal activity under conditions of higher folate nutritional status.	Folic Acid	67-73	methylenetetrahydrofolate reductase	Homo sapiens	111-148
18514430-8	2008	A particular polymorphic form to a key enzyme required to activate folate for methylation in neurodevelopment, 5-methylenetetrahydrofolate reductase (MTHFR), demonstrates reduced activity under low or normal folate levels but normal activity under conditions of higher folate nutritional status.	Folic Acid	67-73	methylenetetrahydrofolate reductase	Homo sapiens	150-155
18514430-8	2008	A particular polymorphic form to a key enzyme required to activate folate for methylation in neurodevelopment, 5-methylenetetrahydrofolate reductase (MTHFR), demonstrates reduced activity under low or normal folate levels but normal activity under conditions of higher folate nutritional status.	Folic Acid	132-138	methylenetetrahydrofolate reductase	Homo sapiens	150-155
18514430-8	2008	A particular polymorphic form to a key enzyme required to activate folate for methylation in neurodevelopment, 5-methylenetetrahydrofolate reductase (MTHFR), demonstrates reduced activity under low or normal folate levels but normal activity under conditions of higher folate nutritional status.	Folic Acid	132-138	methylenetetrahydrofolate reductase	Homo sapiens	150-155
18514430-12	2008	It is hypothesized here that the enhancement of maternal folate status before and during pregnancy in the last 15 years has altered natural selection by increasing survival rates during pregnancy of infants possessing the MTHFR C677T polymorphism, via reduction in hyperhomocysteinemia associated with this genotype and thereby miscarriage rates.	Folic Acid	57-63	methylenetetrahydrofolate reductase	Homo sapiens	222-227
18398434-3	2008	The MTHFR 677TT genotype is known to be associated with increased homocysteine and decreased folate relative to CT heterozygotes and CC homozygotes in this and other populations.	Folic Acid	93-99	methylenetetrahydrofolate reductase	Homo sapiens	4-9
18398434-4	2008	MTHFR 677TT homozygotes who were also CBS 844ins68 carriers had homocysteine and folate concentrations similar to those of individuals with the MTHFR 677CT and CC genotypes.	Folic Acid	81-87	methylenetetrahydrofolate reductase	Homo sapiens	0-5
18398434-6	2008	These findings suggest that the CBS 844ins68 allele "normalizes" homocysteine and folate levels in MTHFR 677TT individuals.	Folic Acid	82-88	methylenetetrahydrofolate reductase	Homo sapiens	99-104
18421714-1	2008	BACKGROUND: 5,10-Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in folate metabolism.	Folic Acid	36-42	methylenetetrahydrofolate reductase	Homo sapiens	54-59
18822146-9	2008	MTHFR is an essential enzyme in folate metabolism and reduced folate levels are associated with both AUD and depression.	Folic Acid	32-38	methylenetetrahydrofolate reductase	Homo sapiens	0-5
18822146-9	2008	MTHFR is an essential enzyme in folate metabolism and reduced folate levels are associated with both AUD and depression.	Folic Acid	62-68	methylenetetrahydrofolate reductase	Homo sapiens	0-5
18614746-6	2008	RESULTS: For all race-ethnicity groups, serum folate and homocysteine concentrations were significantly related to the MTHFR 677C--&gt;T genotype but not to the other polymorphisms.	Folic Acid	46-52	methylenetetrahydrofolate reductase	Homo sapiens	119-124
18614746-7	2008	Persons with the MTHFR 677 TT genotype had a 22.1% (95% CI: 14.6%, 28.9%) lower serum folate and a 25.7% (95% CI: 18.6%, 33.2%) higher homocysteine concentration than did persons with the CC genotype.	Folic Acid	86-92	methylenetetrahydrofolate reductase	Homo sapiens	17-22
18614746-8	2008	Moderate daily folic acid intake (mean: 150 microg/d; 95% CI: 138, 162) significantly reduced the difference in mean homocysteine concentrations between those with the MTHFR 677 CC and TT genotypes.	Folic Acid	15-25	methylenetetrahydrofolate reductase	Homo sapiens	168-173
18614746-10	2008	CONCLUSIONS: The MTHFR 677C--&gt;T polymorphism was associated with significant differences in serum folate and homocysteine concentrations in the US population before folic acid fortification.	Folic Acid	101-107	methylenetetrahydrofolate reductase	Homo sapiens	17-22
18614746-11	2008	The effect of MTHFR 677C--&gt;T on homocysteine concentrations was reduced by moderate daily folic acid intake.	Folic Acid	93-103	methylenetetrahydrofolate reductase	Homo sapiens	14-19
18426813-3	2008	The methylenetetrahydrofolate reductase (MTHFR) C677T TT genotype is associated with reduced folate availability and may be a surrogate for measuring folate levels.	Folic Acid	23-29	methylenetetrahydrofolate reductase	Homo sapiens	41-46
18426813-3	2008	The methylenetetrahydrofolate reductase (MTHFR) C677T TT genotype is associated with reduced folate availability and may be a surrogate for measuring folate levels.	Folic Acid	93-99	methylenetetrahydrofolate reductase	Homo sapiens	4-39
18426813-3	2008	The methylenetetrahydrofolate reductase (MTHFR) C677T TT genotype is associated with reduced folate availability and may be a surrogate for measuring folate levels.	Folic Acid	93-99	methylenetetrahydrofolate reductase	Homo sapiens	41-46
18633250-10	2008	A polymorphism that may influence the efficacy of 5-FU by influencing folate pools is that of the methylenetetrahydrofolate reductase(MTHFR)gene.	Folic Acid	70-76	methylenetetrahydrofolate reductase	Homo sapiens	98-133
18633250-10	2008	A polymorphism that may influence the efficacy of 5-FU by influencing folate pools is that of the methylenetetrahydrofolate reductase(MTHFR)gene.	Folic Acid	70-76	methylenetetrahydrofolate reductase	Homo sapiens	134-139
18452180-11	2008	Of interest is the significant interaction (p = .008) towards a nearly twofold increased risk in mothers carrying the MTHFR 1298C allele and using a periconception folic acid supplement.	Folic Acid	164-174	methylenetetrahydrofolate reductase	Homo sapiens	118-123
18365141-1	2008	Polymorphism in 5,10-methylenetetrahydrofolate reductase (MTHFR), a central enzyme in folate metabolism, has been shown to affect the sensitivity of patients to folate-based drugs such as methotrexate.	Folic Acid	40-46	methylenetetrahydrofolate reductase	Homo sapiens	58-63
18365141-1	2008	Polymorphism in 5,10-methylenetetrahydrofolate reductase (MTHFR), a central enzyme in folate metabolism, has been shown to affect the sensitivity of patients to folate-based drugs such as methotrexate.	Folic Acid	86-92	methylenetetrahydrofolate reductase	Homo sapiens	16-56
18365141-1	2008	Polymorphism in 5,10-methylenetetrahydrofolate reductase (MTHFR), a central enzyme in folate metabolism, has been shown to affect the sensitivity of patients to folate-based drugs such as methotrexate.	Folic Acid	86-92	methylenetetrahydrofolate reductase	Homo sapiens	58-63
18162478-1	2008	Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the metabolism of folate, whose role in gastric carcinogenesis is controversial.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
17726616-2	2008	Methionine synthase (MTR) and cystathionine ss-synthase (CBS) are enzymes that play a central role in folate metabolism, thereby affecting DNA methylation and synthesis.	Folic Acid	102-108	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	0-19
17588738-1	2008	Numerous studies have reported a relationship between folate status, the methylenetetrahydrofolate reductase (MTHFR) 677C--&gt;T variant and disease risk.	Folic Acid	54-60	methylenetetrahydrofolate reductase	Homo sapiens	110-115
17588738-9	2008	The response of phosphatidylcholine to folate intake appeared to be influenced by MTHFR C677T genotype.	Folic Acid	39-45	methylenetetrahydrofolate reductase	Homo sapiens	82-87
18287365-1	2008	There is evidence to suggest that folate, homocysteine, or both affect the (n-3) long chain PUFA composition of tissues; however, this evidence is derived largely from experiments with animals and small observational studies in humans.	Folic Acid	34-40	pumilio RNA binding family member 3	Homo sapiens	92-96
18053312-0	2008	Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, intakes of folate and related B vitamins and colorectal cancer: a case-control study in a population with relatively low folate intake.	Folic Acid	40-46	methylenetetrahydrofolate reductase	Homo sapiens	58-63
18053312-0	2008	Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, intakes of folate and related B vitamins and colorectal cancer: a case-control study in a population with relatively low folate intake.	Folic Acid	82-88	methylenetetrahydrofolate reductase	Homo sapiens	21-56
18053312-0	2008	Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, intakes of folate and related B vitamins and colorectal cancer: a case-control study in a population with relatively low folate intake.	Folic Acid	82-88	methylenetetrahydrofolate reductase	Homo sapiens	58-63
18070159-1	2008	BACKGROUND: A recent study suggested a link between folate metabolism and atopy, based on a positive association between a common polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene and allergic sensitization in Danish adults.	Folic Acid	52-58	methylenetetrahydrofolate reductase	Homo sapiens	150-185
18070159-1	2008	BACKGROUND: A recent study suggested a link between folate metabolism and atopy, based on a positive association between a common polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene and allergic sensitization in Danish adults.	Folic Acid	52-58	methylenetetrahydrofolate reductase	Homo sapiens	187-192
18245544-8	2008	MTHFR c.677 influenced pretreatment homocysteine (P &lt; 0.05) and serum folate levels (P &lt; 0.05).	Folic Acid	73-79	methylenetetrahydrofolate reductase	Homo sapiens	0-5
18245544-11	2008	In addition, MTHFR single nucleotide polymorphisms predicted serum folate and plasma homocysteine levels, and, combined, these factors may be important predictors of capecitabine-induced toxicity.	Folic Acid	67-73	methylenetetrahydrofolate reductase	Homo sapiens	13-18
17531458-2	2008	Our group has previously shown that both reduced folate carrier (RFC1) and folate receptor alpha (FRalpha) seem to be involved in the uptake of [3H]folic acid ([3H]FA) by a human trophoblast cell line (BeWo) and by human primary cultured cytotrophoblasts.	Folic Acid	49-55	replication factor C subunit 1	Homo sapiens	65-69
17531458-2	2008	Our group has previously shown that both reduced folate carrier (RFC1) and folate receptor alpha (FRalpha) seem to be involved in the uptake of [3H]folic acid ([3H]FA) by a human trophoblast cell line (BeWo) and by human primary cultured cytotrophoblasts.	Folic Acid	148-158	replication factor C subunit 1	Homo sapiens	65-69
18586656-2	2008	The aim of this study was to investigate the relations between the methylenetetrafolate reductase (MTHFR) 677C--&gt;T genotypes, B-vitamins (folate, vitamin B-12 and B-6), homocysteine and the risk of CAD.	Folic Acid	81-87	methylenetetrahydrofolate reductase	Homo sapiens	99-104
18022874-2	2008	The mutations on two genes involved in folate metabolism, the C677 of the MTHFR gene and the RFC-1(A80G) gene are potential risk factors of NTDs.	Folic Acid	39-45	methylenetetrahydrofolate reductase	Homo sapiens	74-79
18022874-2	2008	The mutations on two genes involved in folate metabolism, the C677 of the MTHFR gene and the RFC-1(A80G) gene are potential risk factors of NTDs.	Folic Acid	39-45	replication factor C subunit 1	Homo sapiens	93-97
18406541-2	2008	Genetic polymorphisms in folate pathway related enzymes including methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, methionine synthase (MTR) A2756G, thymidylate synthase (TS) 28-bp tandem repeat, and reduced folate carrier (RFC) G80A have been shown to be associated with increased susceptibility for several cancers.	Folic Acid	25-31	methylenetetrahydrofolate reductase	Homo sapiens	66-101
18406541-2	2008	Genetic polymorphisms in folate pathway related enzymes including methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, methionine synthase (MTR) A2756G, thymidylate synthase (TS) 28-bp tandem repeat, and reduced folate carrier (RFC) G80A have been shown to be associated with increased susceptibility for several cancers.	Folic Acid	25-31	methylenetetrahydrofolate reductase	Homo sapiens	103-108
18406541-2	2008	Genetic polymorphisms in folate pathway related enzymes including methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, methionine synthase (MTR) A2756G, thymidylate synthase (TS) 28-bp tandem repeat, and reduced folate carrier (RFC) G80A have been shown to be associated with increased susceptibility for several cancers.	Folic Acid	25-31	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	128-147
18406541-2	2008	Genetic polymorphisms in folate pathway related enzymes including methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, methionine synthase (MTR) A2756G, thymidylate synthase (TS) 28-bp tandem repeat, and reduced folate carrier (RFC) G80A have been shown to be associated with increased susceptibility for several cancers.	Folic Acid	85-91	methylenetetrahydrofolate reductase	Homo sapiens	103-108
18160726-1	2008	BACKGROUND: The 5,10-methylenetetrahydrofolate reductase (NADPH) (MTHFR) C677T polymorphism may affect whole-blood folate pattern measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and total folate measured by LC-MS/MS, microbiologic assay, and Bio-Rad radioassay (BR).	Folic Acid	40-46	2,4-dienoyl-CoA reductase 1	Homo sapiens	58-63
18160726-1	2008	BACKGROUND: The 5,10-methylenetetrahydrofolate reductase (NADPH) (MTHFR) C677T polymorphism may affect whole-blood folate pattern measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and total folate measured by LC-MS/MS, microbiologic assay, and Bio-Rad radioassay (BR).	Folic Acid	40-46	methylenetetrahydrofolate reductase	Homo sapiens	66-71
18160726-1	2008	BACKGROUND: The 5,10-methylenetetrahydrofolate reductase (NADPH) (MTHFR) C677T polymorphism may affect whole-blood folate pattern measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and total folate measured by LC-MS/MS, microbiologic assay, and Bio-Rad radioassay (BR).	Folic Acid	115-121	2,4-dienoyl-CoA reductase 1	Homo sapiens	58-63
18160726-1	2008	BACKGROUND: The 5,10-methylenetetrahydrofolate reductase (NADPH) (MTHFR) C677T polymorphism may affect whole-blood folate pattern measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and total folate measured by LC-MS/MS, microbiologic assay, and Bio-Rad radioassay (BR).	Folic Acid	115-121	methylenetetrahydrofolate reductase	Homo sapiens	66-71
18160726-9	2008	CONCLUSION: MTHFR C677T polymorphism influences the folate pattern in whole blood.	Folic Acid	52-58	methylenetetrahydrofolate reductase	Homo sapiens	12-17
19075497-3	2008	This study aimed to assess the effect of folic acid supplementation quantitatively in MTHFR haplotypes, and compare its prediction power with that of the C677T single nucleotide polymorphism (SNP) alone.	Folic Acid	41-51	methylenetetrahydrofolate reductase	Homo sapiens	86-91
19918112-0	2008	Preliminary evidence for genetic selection of 677T-MTHFR by natural annual cycle of folate abundance.	Folic Acid	84-90	methylenetetrahydrofolate reductase	Homo sapiens	51-56
19918112-3	2008	We show that historically, the seasonal cycle of abundance of folate-rich foods may have regulated embryo viability by acting as a selection factor for a significant polymorphism within a gene encoding 5,10-methylenetetrahydrofolate reductase (677C--&gt;T-MTHFR).	Folic Acid	62-68	methylenetetrahydrofolate reductase	Homo sapiens	256-261
18065205-0	2008	Mandatory fortification with folic acid in the United States is associated with increased expression of DNA methyltransferase-1 in the cervix.	Folic Acid	29-39	DNA methyltransferase 1	Homo sapiens	104-127
18065205-1	2008	OBJECTIVE: The objective of this study was to evaluate whether mandatory fortification of grain products with folic acid in the United States is associated with changes in DNA methyltransferase-1 (Dnmt-1) expression in cells involved in cervical carcinogenesis.	Folic Acid	110-120	DNA methyltransferase 1	Homo sapiens	172-195
18065205-1	2008	OBJECTIVE: The objective of this study was to evaluate whether mandatory fortification of grain products with folic acid in the United States is associated with changes in DNA methyltransferase-1 (Dnmt-1) expression in cells involved in cervical carcinogenesis.	Folic Acid	110-120	DNA methyltransferase 1	Homo sapiens	197-203
18065205-7	2008	CONCLUSION: These results suggest that mandatory fortification with folic acid in the United States seems to have resulted in a change in the degree of expression of Dnmt-1 in cells involved in cervical carcinogenesis.	Folic Acid	68-78	DNA methyltransferase 1	Homo sapiens	166-172
18065205-8	2008	Because the approach we have taken to demonstrate these differences have limitations inherent to a study of this nature and this is the first study to report a folate fortification associated change in Dnmt-1, validating these results in other study populations and/or with other techniques of assessing Dnmt-1 will increase the scientific credibility of these findings.	Folic Acid	160-166	DNA methyltransferase 1	Homo sapiens	202-208
18065205-8	2008	Because the approach we have taken to demonstrate these differences have limitations inherent to a study of this nature and this is the first study to report a folate fortification associated change in Dnmt-1, validating these results in other study populations and/or with other techniques of assessing Dnmt-1 will increase the scientific credibility of these findings.	Folic Acid	160-166	DNA methyltransferase 1	Homo sapiens	304-310
19172696-2	2008	In this nested case-referent study, we related two such polymorphisms, reduced folate carrier (RFC1) 80G &gt; A and folate hydrolase 1 (FOLH1) 1561C &gt; T, to the risk of colorectal cancer, taking into account pre-diagnostic plasma folate and total homocysteine concentrations and the MTHFR 677C &gt; T polymorphism, which were analysed in a previous study.	Folic Acid	116-122	methylenetetrahydrofolate reductase	Homo sapiens	286-291
19172696-4	2008	RESULTS: The RFC1 80A-allele was associated with reduced plasma folate and elevated plasma total homocysteine concentrations, but the result was statistically significant only for folate.	Folic Acid	64-70	replication factor C subunit 1	Homo sapiens	13-17
19172696-4	2008	RESULTS: The RFC1 80A-allele was associated with reduced plasma folate and elevated plasma total homocysteine concentrations, but the result was statistically significant only for folate.	Folic Acid	180-186	replication factor C subunit 1	Homo sapiens	13-17
19172696-9	2008	CONCLUSIONS: These findings suggest that although the RFC1 80G &gt; A and FOLH1 1561C &gt; T polymorphisms may influence folate status, they are not likely to have a major independent role in the development of colorectal cancer.	Folic Acid	121-127	replication factor C subunit 1	Homo sapiens	54-58
19424840-1	2007	The homocysteine level is considered to be a product of genetic and lifestyle interactions, mainly mutated methylenetetrahydrofolate reductase (MTHFR) and the intake of folate, vitamin B12 and pyridoxine, and their blood levels.	Folic Acid	126-132	methylenetetrahydrofolate reductase	Homo sapiens	144-149
17712558-2	2007	Methylenetetrahydrofolate reductase (MTHFR) balances the pool of folate coenzymes in one carbon metabolism of deoxyribonucleic acid (DNA) synthesis and methylation; both are implicated in carcinogenesis of many types of cancer including lymphoma.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
18194124-2	2007	The drug exerts its effect on folate metabolism; 5,10-methylenetetrahydrofolate reductase is a critical enzyme involved in this cycle and is related to the toxicity of methotrexate.	Folic Acid	30-36	methylenetetrahydrofolate reductase	Homo sapiens	54-89
18187886-3	2007	To elucidate the phylogeny of these PGA-producing strains, phylogenetic trees based on sequences of 16S rDNA, housekeeping genes of rpoB (RNA polymerase beta-subunit) and fus (elongation factor G) were constructed.	Folic Acid	36-39	RNA polymerase beta chain	Glycine max	138-174
18029487-10	2007	Similarly, minor changes in the expression of Apc, beta-catenin, and cyclin D1 produced by mild folate depletion were significantly magnified by multiple vitamin depletion.	Folic Acid	96-102	catenin (cadherin associated protein), beta 1	Mus musculus	51-63
18029487-10	2007	Similarly, minor changes in the expression of Apc, beta-catenin, and cyclin D1 produced by mild folate depletion were significantly magnified by multiple vitamin depletion.	Folic Acid	96-102	cyclin D1	Mus musculus	69-78
17325736-2	2007	MTX enters the cells through the reduced folate carrier (RFC-1) and is activated to polyglutamates.	Folic Acid	41-47	replication factor C subunit 1	Homo sapiens	57-62
17325736-4	2007	The studies suggest that G80A polymorphism in RFC-1 is associated with altered folate/antifolate levels and the subjects carrying homozygous mutant 80AA genotype tend to have higher plasma folate and MTX concentrations and higher erythrocyte polyglutamate levels compared with those with the wild type or heterozygous genotype.	Folic Acid	79-85	replication factor C subunit 1	Homo sapiens	46-51
17325736-4	2007	The studies suggest that G80A polymorphism in RFC-1 is associated with altered folate/antifolate levels and the subjects carrying homozygous mutant 80AA genotype tend to have higher plasma folate and MTX concentrations and higher erythrocyte polyglutamate levels compared with those with the wild type or heterozygous genotype.	Folic Acid	90-96	replication factor C subunit 1	Homo sapiens	46-51
17965089-2	2007	Identification of candidate genes in folate metabolism has suggested that the 677C--&gt;T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene may be particularly associated with the risk of CHDs.	Folic Acid	37-43	methylenetetrahydrofolate reductase	Homo sapiens	110-145
17965089-2	2007	Identification of candidate genes in folate metabolism has suggested that the 677C--&gt;T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene may be particularly associated with the risk of CHDs.	Folic Acid	37-43	methylenetetrahydrofolate reductase	Homo sapiens	147-152
17898134-7	2007	Uptake of folates in PCFT-injected Xenopus oocytes was electrogenic and pH dependent.	Folic Acid	10-17	solute carrier family 46, member 1	Mus musculus	21-25
17898134-12	2007	MmPCFT mRNA levels increased approximately 13-fold in the proximal small intestine in mice fed a folate-deficient vesus folate-replete diet, consistent with the critical role that PCFT plays in intestinal folate absorption.	Folic Acid	97-103	solute carrier family 46, member 1	Mus musculus	2-6
17972183-1	2007	Methylenetetrahydrofolate reductase (MTHFR) plays a central role in the metabolism of folate, which provides a methyl donor for DNA methylation and deoxynucleoside synthesis.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
17962486-10	2007	In X. laevis oocytes expressing the cloned mouse PCFT, folate and its derivatives methotrexate and 5-methyltetrahydrofolate induced H(+)-coupled inward currents with K(t) values of 1.2 +/- 0.1, 4.6 +/- 0.5, and 3.5 +/- 0.8 microM, respectively.	Folic Acid	55-61	solute carrier family 46, member 1	Mus musculus	49-53
17962486-11	2007	The transport process showed an H(+)-folate stoichiometry of 1:1, suggesting that PCFT transports the zwitterionic form of folate.	Folic Acid	37-43	solute carrier family 46, member 1	Mus musculus	82-86
17962486-14	2007	Mouse PCFT, cloned from retina, mediates H(+)-coupled electrogenic transport of folate and its derivatives.	Folic Acid	80-86	solute carrier family 46, member 1	Mus musculus	6-10
18034620-2	2007	Methylenetetrahydrofolate reductase (MTHFR) is involved in folate metabolism and has been shown to be polymorphic, affecting the enzyme activity.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
18034620-6	2007	CONCLUSION: The results of our study suggest that the MTHFR 677T and 1298C alleles may be associated with an increased rate of RA remission in patients treated with MTX receiving high doses of folic acid supplementation.	Folic Acid	193-203	methylenetetrahydrofolate reductase	Homo sapiens	54-59
18195462-3	2007	Methylenetetrahydrofolate reductase (MTHFR) is involved in the folate metabolism and has been shown to be polymorphic what affects the enzyme activity.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
17711493-2	2007	5,10-Methylenetetrahydrofolate reductase (MTHFR) is involved in folate metabolism and its C677T polymorphism may be more prevalent in migraine.	Folic Acid	24-30	methylenetetrahydrofolate reductase	Homo sapiens	42-47
17922421-1	2007	OBJECTIVE: To investigate whether the polymorphism in methylenetetrahydrofolate reductase (MTHFR) gene involved in folate metabolism is associated with Down syndrome (DS).	Folic Acid	73-79	methylenetetrahydrofolate reductase	Homo sapiens	91-96
17702010-1	2007	We recently observed an association between combinations of polymorphisms in the methylenetetrahydrofolate reductase (MTHFR 677C &gt; T or 1298A &gt; C) and reduced folate carrier (RFC-1 80G &gt; A) genes and the risk of a Down syndrome (DS) pregnancy in young Italian women.	Folic Acid	100-106	methylenetetrahydrofolate reductase	Homo sapiens	118-123
17970089-1	2007	BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) plays a central role in converting folate to methyl donor for DNA methylation.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	49-54
17970089-2	2007	Because MTHFR is a key enzyme in folate metabolism, changes in its activity resulting from polymorphisms in the MTHFR gene could modify the susceptibility to cancer.	Folic Acid	33-39	methylenetetrahydrofolate reductase	Homo sapiens	8-13
17970089-2	2007	Because MTHFR is a key enzyme in folate metabolism, changes in its activity resulting from polymorphisms in the MTHFR gene could modify the susceptibility to cancer.	Folic Acid	33-39	methylenetetrahydrofolate reductase	Homo sapiens	112-117
17683808-1	2007	Methionine synthase is a key enzyme poised at the intersection of folate and sulfur metabolism and functions to reclaim homocysteine to the methionine cycle.	Folic Acid	66-72	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	0-19
17596206-2	2007	Functional polymorphisms in genes encoding one-carbon metabolism enzymes, such as methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), methionine synthase (MTR A2756G), methionine synthase reductase (MTRR A66G) and thymidylate synthase (TS), influence folate metabolism and thus might impact on HNSCC risk.	Folic Acid	101-107	methylenetetrahydrofolate reductase	Homo sapiens	119-124
17704422-1	2007	PURPOSE: Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme regulating intracellular folate levels, which affects DNA synthesis and methylation.	Folic Acid	28-34	methylenetetrahydrofolate reductase	Homo sapiens	46-51
17468511-2	2007	Functional polymorphisms in genes encoding one-carbon metabolism enzymes, methylenetetrahydrofolate reductase (MTHFR C677T and A1,298C), methionine synthase (MTR A2,756G), methionine synthase reductase (MTRR A66G) and thymidylate synthase, influence folate metabolism and thus might be suspected of impacting on lung cancer risk.	Folic Acid	93-99	methylenetetrahydrofolate reductase	Homo sapiens	111-116
17537830-2	2007	AIMS: The aim of this study was to study the reverse effect of folic acid administered during gestation and lactation to ethanol-treated dams, on cholecystokinin Cholecystokinin (CCK) stimulus-secretion coupling in pancreatic exocrine secretion in offspring rats.	Folic Acid	63-73	cholecystokinin	Rattus norvegicus	146-177
17537830-2	2007	AIMS: The aim of this study was to study the reverse effect of folic acid administered during gestation and lactation to ethanol-treated dams, on cholecystokinin Cholecystokinin (CCK) stimulus-secretion coupling in pancreatic exocrine secretion in offspring rats.	Folic Acid	63-73	cholecystokinin	Rattus norvegicus	179-182
17537830-6	2007	After CCK stimulation, a significant decrease in amylase, lipase and chymotrypsin activities in the duodenal juice were detected in ethanol, this trend was partially corrected with folate supplementation.	Folic Acid	181-187	cholecystokinin	Rattus norvegicus	6-9
17574963-3	2007	Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MS) are enzymes that play central roles in the folate metabolic pathway.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
17574963-3	2007	Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MS) are enzymes that play central roles in the folate metabolic pathway.	Folic Acid	19-25	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	48-67
17687709-3	2007	METHOD: The physiology of the one-carbon cycle, involving folate, cobalamin, homocysteine, S-adenosyl-methionine, and methylene tetrahydrofolate reductase (MTHFR) is first reviewed, and then the particular contributions of folate and B12 are reviewed.	Folic Acid	138-144	methylenetetrahydrofolate reductase	Homo sapiens	156-161
17533620-5	2007	Consistent with this, FIG selection also retrieved: the PMA1 gene, encoding the plasma H(+)-membrane ATPase; FOL2 and FOL3, involved in folic acid biosynthesis; and UBR2, which indirectly downregulates the proteasome genes.	Folic Acid	136-146	dihydrofolate synthase	Saccharomyces cerevisiae S288C	118-122
17482559-1	2007	The sodium dependent reduced folate carrier (Rfc1; Slc19a1) provides the major route for cellular uptake of reduced folates and antifolate drugs such as methotrexate (MTX) into various tissues.	Folic Acid	116-123	replication factor C subunit 1	Rattus norvegicus	45-49
17412321-1	2007	We have examined the prevalence of the C677T and A1298C single nucleotide polymorphisms (SNPs) in the methylenetetrahydrofolate reductase (MTHFR) gene in healthy Tamilians and in patients with acute myocardial infarction and related this polymorphism to plasma homocysteine concentrations, serum folate, serum cobalamin and riboflavin status.	Folic Acid	121-127	methylenetetrahydrofolate reductase	Homo sapiens	139-144
17436239-6	2007	Conversely, the MTHFR polymorphism influenced B vitamin effects, which were strongest in the TT group, in which the estimated tHcy difference between subjects with vitamin concentrations in the lowest compared with the highest quartile was 5.4 micromol/liter for folate, 4.1 micromol/liter for riboflavin, 3.2 micromol/liter for cobalamin, and 2.1 micromol/liter for vitamin B6.	Folic Acid	263-269	methylenetetrahydrofolate reductase	Homo sapiens	16-21
17301815-1	2007	The homozygous mutation (677TT) in the methylenetetrahydrofolate reductase (MTHFR) gene reduces enzyme activity and alters cellular folate composition.	Folic Acid	58-64	methylenetetrahydrofolate reductase	Homo sapiens	76-81
17301815-5	2007	MTHFR TT genotype significantly reduced folate-dependent remethylation under folate restriction, reflecting limited methylated folates under folate restriction.	Folic Acid	40-46	methylenetetrahydrofolate reductase	Homo sapiens	0-5
17301815-5	2007	MTHFR TT genotype significantly reduced folate-dependent remethylation under folate restriction, reflecting limited methylated folates under folate restriction.	Folic Acid	77-83	methylenetetrahydrofolate reductase	Homo sapiens	0-5
17301815-5	2007	MTHFR TT genotype significantly reduced folate-dependent remethylation under folate restriction, reflecting limited methylated folates under folate restriction.	Folic Acid	127-134	methylenetetrahydrofolate reductase	Homo sapiens	0-5
17301815-5	2007	MTHFR TT genotype significantly reduced folate-dependent remethylation under folate restriction, reflecting limited methylated folates under folate restriction.	Folic Acid	77-83	methylenetetrahydrofolate reductase	Homo sapiens	0-5
17151354-7	2007	Chronic ethanol consumption increased testis folate concentrations and decreased testis methionine synthase activity, whereas folate deficiency reduced total testis folate levels and increased methionine synthase activity.	Folic Acid	126-132	5-methyltetrahydrofolate-homocysteine methyltransferase	Sus scrofa	193-212
17151354-8	2007	In all pigs combined, testicular methionine synthase activity was negatively associated with circulating estradiol, LH and FSH, and 17,20-lyase activity after controlling for ethanol, folate deficiency, and their interaction.	Folic Acid	184-190	5-methyltetrahydrofolate-homocysteine methyltransferase	Sus scrofa	33-52
17245555-0	2007	Dietary intake of folate and co-factors in folate metabolism, MTHFR polymorphisms, and reduced rectal cancer.	Folic Acid	18-24	methylenetetrahydrofolate reductase	Homo sapiens	62-67
17245555-1	2007	Little is known about the contribution of polymorphisms in the methylenetetrahydrofolate reductase gene (MTHFR) and the folate metabolism pathway in rectal cancer alone.	Folic Acid	82-88	methylenetetrahydrofolate reductase	Homo sapiens	105-110
17353633-5	2007	The leucovorin-induced potentiation of TS-1 antitumor activity was obviously higher in COL-1 tumor-bearing mice fed a low folate diet than in mice fed a normal diet.	Folic Acid	122-128	Trichinella spiralis resistance 1	Mus musculus	39-43
17353633-6	2007	The remarkable increase in reduced folate levels following the administration of leucovorin contributed to the leucovorin-induced potentiation of TS-1 antitumor activity in this low-folate-diet animal model.	Folic Acid	35-41	Trichinella spiralis resistance 1	Mus musculus	146-150
17353633-6	2007	The remarkable increase in reduced folate levels following the administration of leucovorin contributed to the leucovorin-induced potentiation of TS-1 antitumor activity in this low-folate-diet animal model.	Folic Acid	182-188	Trichinella spiralis resistance 1	Mus musculus	146-150
17349292-1	2007	Methylenetetrahydrofolate reductase (MTHFR) is a key regulatory enzyme in folate and homocysteine metabolism.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
17329909-1	2007	Stereoselectivity of the human reduced folate carrier (RFC1) in Caco-2 cells was examined using methotrexate (L-amethopterin, L-MTX) and its antipode (D-amethopterin, D-MTX) as model substrates.	Folic Acid	39-45	replication factor C subunit 1	Homo sapiens	55-59
17219389-2	2007	The methylenetetrahydrofolate reductase gene (MTHFR) plays a major role in folate metabolism, and several polymorphisms, including C677T, are common in European populations.	Folic Acid	23-29	methylenetetrahydrofolate reductase	Homo sapiens	46-51
17301261-15	2007	Our findings suggest that folate intake may decrease the risk of endometrial cancer and modify the effect of MTHFR polymorphisms on risk.	Folic Acid	26-32	methylenetetrahydrofolate reductase	Homo sapiens	109-114
17053001-2	2007	Methylenetetrahydrofolate reductase (MTHFR) regulates the flow of folic acid-derived, one-carbon moieties for methylation and is critical to early embryonic development.	Folic Acid	66-76	methylenetetrahydrofolate reductase	Homo sapiens	0-35
17053001-2	2007	Methylenetetrahydrofolate reductase (MTHFR) regulates the flow of folic acid-derived, one-carbon moieties for methylation and is critical to early embryonic development.	Folic Acid	66-76	methylenetetrahydrofolate reductase	Homo sapiens	37-42
17118406-8	2007	The administration of folic acid decreased atherosclerotic lesions independently of plasma homocysteine and cholesterol levels, but was associated with plasma levels of apolipoproteins A-I, A-IV and B, and decreased oxidative stress.	Folic Acid	22-32	annexin A4	Mus musculus	169-200
17074966-7	2007	This meta-analysis demonstrates an association between the MTHFR C677T variant and depression, schizophrenia, and bipolar disorder, raising the possibility of the use of folate in treatment and prevention.	Folic Acid	170-176	methylenetetrahydrofolate reductase	Homo sapiens	59-64
17438654-3	2007	Folate deficiency is associated with cancer risk that may be modulated by a genetic variation in the MTHFR gene in folate metabolism.	Folic Acid	115-121	methylenetetrahydrofolate reductase	Homo sapiens	101-106
18167510-3	2007	The methylenetetrahydrofolate reductase (MTHFR) 677C--&gt;T variant is an important determinant of folate nutriture and may influence DNA methylation.	Folic Acid	23-29	methylenetetrahydrofolate reductase	Homo sapiens	41-46
18167510-8	2007	However, at the end of folate treatment (wk 14), DNA methylation was lower (P&lt;0.05) in women with the MTHFR 677TT genotype relative to the CT or CC genotype.	Folic Acid	23-29	methylenetetrahydrofolate reductase	Homo sapiens	105-110
18333369-7	2007	Although methylenetetrahydrofolate reductase (MTHFR) C677T genotype and deficits of folic acid, vitamin B12 lead to hyperhomocysteinemia, in cases with a thrombotic event the correlations between homocysteine level and folic acid as well as between homocysteinemia and vitamin B12 were found to be weak and no significant correlation between homocysteinemia and MTHFR was identified.	Folic Acid	219-229	methylenetetrahydrofolate reductase	Homo sapiens	9-44
18333369-7	2007	Although methylenetetrahydrofolate reductase (MTHFR) C677T genotype and deficits of folic acid, vitamin B12 lead to hyperhomocysteinemia, in cases with a thrombotic event the correlations between homocysteine level and folic acid as well as between homocysteinemia and vitamin B12 were found to be weak and no significant correlation between homocysteinemia and MTHFR was identified.	Folic Acid	219-229	methylenetetrahydrofolate reductase	Homo sapiens	46-51
17243563-1	2006	The aim of the study was to investigate the association between methylenetetrahydrofolate (MTHFR) genotypes and levels of homocysteine (Hcy), folate, vitamin B12 and lipids as well as the association between apolipoprotein E (apo E) genotypes and levels of lipids in a Croatian healthy control group and a group of patients with &gt; 70% carotid stenosis (CS).	Folic Acid	83-89	methylenetetrahydrofolate reductase	Homo sapiens	91-96
16861746-1	2006	BACKGROUND: Three typical folate metabolism enzymes-i.e. methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MS) and MS reductase (MTRR) in the folate cycle-play a critical role in DNA synthesis and methylation reactions.	Folic Acid	26-32	methylenetetrahydrofolate reductase	Homo sapiens	57-92
16861746-1	2006	BACKGROUND: Three typical folate metabolism enzymes-i.e. methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MS) and MS reductase (MTRR) in the folate cycle-play a critical role in DNA synthesis and methylation reactions.	Folic Acid	26-32	methylenetetrahydrofolate reductase	Homo sapiens	94-99
16861746-1	2006	BACKGROUND: Three typical folate metabolism enzymes-i.e. methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MS) and MS reductase (MTRR) in the folate cycle-play a critical role in DNA synthesis and methylation reactions.	Folic Acid	26-32	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	102-121
16936070-3	2006	Low folate status in pregnant women has been implicated in several congenital malformations, and folate metabolism may be affected by polymorphisms in the methylenetetrahydrofolate reductase gene (MTHFR).	Folic Acid	4-10	methylenetetrahydrofolate reductase	Homo sapiens	197-202
16936070-3	2006	Low folate status in pregnant women has been implicated in several congenital malformations, and folate metabolism may be affected by polymorphisms in the methylenetetrahydrofolate reductase gene (MTHFR).	Folic Acid	97-103	methylenetetrahydrofolate reductase	Homo sapiens	155-190
16936070-3	2006	Low folate status in pregnant women has been implicated in several congenital malformations, and folate metabolism may be affected by polymorphisms in the methylenetetrahydrofolate reductase gene (MTHFR).	Folic Acid	97-103	methylenetetrahydrofolate reductase	Homo sapiens	197-202
17079455-0	2006	Low dietary folate initiates intestinal tumors in mice, with altered expression of G2-M checkpoint regulators polo-like kinase 1 and cell division cycle 25c.	Folic Acid	12-18	polo like kinase 1	Mus musculus	110-128
17079455-10	2006	Our data suggest that folate deficiency can initiate tumor development, that Mthfr mutation can enhance this phenomenon, and that altered expression of Plk1 and Cdc25c may contribute to folate-dependent intestinal tumorigenesis.	Folic Acid	186-192	polo like kinase 1	Mus musculus	152-156
16524711-0	2006	Additional food folate derived exclusively from natural sources improves folate status in young women with the MTHFR 677 CC or TT genotype.	Folic Acid	16-22	methylenetetrahydrofolate reductase	Homo sapiens	111-116
16524711-0	2006	Additional food folate derived exclusively from natural sources improves folate status in young women with the MTHFR 677 CC or TT genotype.	Folic Acid	73-79	methylenetetrahydrofolate reductase	Homo sapiens	111-116
17052662-2	2006	Folates and vitamin B12 have fundamental roles in CNS function at all ages, especially the methionine-synthase mediated conversion of homocysteine to methionine, which is essential for nucleotide synthesis and genomic and non-genomic methylation.	Folic Acid	0-7	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	91-110
16924677-3	2006	Here, we report changes in miR expression profile in hepatocellular carcinomas (HCCs) developed in male Fisher rats-fed folic acid, methionine, and choline-deficient (FMD) diet.	Folic Acid	120-130	membrane associated ring-CH-type finger 8	Rattus norvegicus	27-30
17030196-2	2006	We conducted a systematic review with meta-analysis of epidemiologic studies evaluating the association of folate intake or genetic polymorphisms in 5,10-methylenetetrahydrofolate reductase (MTHFR), a central enzyme in folate metabolism, with risk of esophageal, gastric, or pancreatic cancer.	Folic Acid	173-179	methylenetetrahydrofolate reductase	Homo sapiens	191-196
16646054-5	2006	We also investigated the association of methylation silencing with functional polymorphisms in the folate metabolism enzyme methylene tetrahydrofolate reductase (MTHFR).	Folic Acid	99-105	methylenetetrahydrofolate reductase	Homo sapiens	162-167
16646054-7	2006	Furthermore, this increased risk for epigenetic silencing at p16(INK4A) was modified by the MTHFR alleles previously associated with diminished serum folate levels.	Folic Acid	150-156	methylenetetrahydrofolate reductase	Homo sapiens	92-97
16646054-8	2006	Hence, in HNSCC low dietary intake of folate is associated with p16(INK4A) methylation, and this relationship is modified by the MTHFR genotype.	Folic Acid	38-44	methylenetetrahydrofolate reductase	Homo sapiens	129-134
16690736-4	2006	Serum folate concentrations were related to MTHFR 677 TT genotype in persons with folate intake in the lowest tertile (&lt; 221.2 microg/day).	Folic Acid	6-12	methylenetetrahydrofolate reductase	Homo sapiens	44-49
16690736-4	2006	Serum folate concentrations were related to MTHFR 677 TT genotype in persons with folate intake in the lowest tertile (&lt; 221.2 microg/day).	Folic Acid	82-88	methylenetetrahydrofolate reductase	Homo sapiens	44-49
16450391-3	2006	We have previously observed a protective effect of maternal folate supplementation during pregnancy against ALL, and a number of studies have reported protective effects of some common polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene.	Folic Acid	60-66	methylenetetrahydrofolate reductase	Homo sapiens	243-248
16450391-4	2006	One study has suggested that the effect of MTHFR polymorphisms on risk of ALL may depend on folate status.	Folic Acid	92-98	methylenetetrahydrofolate reductase	Homo sapiens	43-48
16621645-0	2006	The MTHFR 1298CC and 677TT genotypes have opposite associations with red cell folate levels.	Folic Acid	78-84	methylenetetrahydrofolate reductase	Homo sapiens	4-9
16575899-0	2006	Maternal polymorphisms 677C-T and 1298A-C of MTHFR, and 66A-G MTRR genes: is there any relationship between polymorphisms of the folate pathway, maternal homocysteine levels, and the risk for having a child with Down syndrome?	Folic Acid	129-135	methylenetetrahydrofolate reductase	Homo sapiens	45-50
16651609-0	2006	Attenuation of folic acid-induced renal inflammatory injury in platelet-activating factor receptor-deficient mice.	Folic Acid	15-25	platelet-activating factor receptor	Mus musculus	63-98
16651609-7	2006	These results indicate that PAF is involved in pathogenesis of folic acid-induced renal injury by activating neutrophils in acute phase and macrophages in chronic interstitial fibrosis.	Folic Acid	63-73	patchy fur	Mus musculus	28-31
16821630-1	2006	BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) plays a role in DNA biosynthesis, methylation and repair in actively dividing cells by acting on folate metabolism.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	49-54
16332725-8	2006	The impact of ALDH2 Lys+ with ADH2 Arg+ was more evident in low folate consumer (OR = 2.32, 1.19-4.55) than high folate consumer (OR 1.38, 0.80-2.38).	Folic Acid	64-70	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	30-34
16332725-8	2006	The impact of ALDH2 Lys+ with ADH2 Arg+ was more evident in low folate consumer (OR = 2.32, 1.19-4.55) than high folate consumer (OR 1.38, 0.80-2.38).	Folic Acid	113-119	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	30-34
16605249-18	2006	Conformation changes induced by folate binding may also suppress dissociation of FAD.	Folic Acid	32-38	BRCA2 DNA repair associated	Homo sapiens	81-84
16796406-11	2006	Anyway, we suggest that, because of the high prevalence of the mutation MTHFR C677T found, screening should be made in the thombophilia studies, so that we could find patients with a risk factor that could be lowered by folates in the diet.	Folic Acid	220-227	methylenetetrahydrofolate reductase	Homo sapiens	72-77
16612468-2	2006	The C677T polymorphism for the gene that encodes the methylenetetrahydrofolate reductase enzyme (MTHFR) and low plasma folate levels are common causes of hyperhomocystinemia.	Folic Acid	72-78	methylenetetrahydrofolate reductase	Homo sapiens	97-102
16524890-0	2006	Maternal MTHFR 677C&gt;T is a risk factor for congenital heart defects: effect modification by periconceptional folate supplementation.	Folic Acid	112-118	methylenetetrahydrofolate reductase	Homo sapiens	9-14
16524890-2	2006	The search for candidate genes involved in the folate metabolism includes the methylenetetrahydrofolate reductase (MTHFR) 677C &gt; T polymorphism.	Folic Acid	47-53	methylenetetrahydrofolate reductase	Homo sapiens	78-113
16524890-2	2006	The search for candidate genes involved in the folate metabolism includes the methylenetetrahydrofolate reductase (MTHFR) 677C &gt; T polymorphism.	Folic Acid	47-53	methylenetetrahydrofolate reductase	Homo sapiens	115-120
16524890-8	2006	In a case-only study, the interaction between periconceptional folate supplementation and maternal MTHFR genotype was significant (P = 0.012).	Folic Acid	63-69	methylenetetrahydrofolate reductase	Homo sapiens	99-104
16402130-3	2006	A common polymorphism (C677T) in MTHFR is associated with methyltetrahydrofolate reductase (MTHFR) activity and circulating folate and homocysteine levels and offers insights into whether the association between low folate and depression is causal.	Folic Acid	74-80	methylenetetrahydrofolate reductase	Homo sapiens	33-38
16402130-3	2006	A common polymorphism (C677T) in MTHFR is associated with methyltetrahydrofolate reductase (MTHFR) activity and circulating folate and homocysteine levels and offers insights into whether the association between low folate and depression is causal.	Folic Acid	74-80	methylenetetrahydrofolate reductase	Homo sapiens	92-97
16402130-3	2006	A common polymorphism (C677T) in MTHFR is associated with methyltetrahydrofolate reductase (MTHFR) activity and circulating folate and homocysteine levels and offers insights into whether the association between low folate and depression is causal.	Folic Acid	124-130	methylenetetrahydrofolate reductase	Homo sapiens	33-38
16464657-5	2006	When folate status was below the median, 5,10-methylenetetrahydrofolate reductase (MTHFR) 677TT homozygotes had similar hearing levels to subjects with a C allele.	Folic Acid	5-11	methylenetetrahydrofolate reductase	Homo sapiens	41-81
16464657-6	2006	However, when folate status was above the median, MTHFR 677TT homozygotes had on an average 5 dB (p = 0.037) and 2.6 dB (p = 0.021) lower PTA-high and PTA-low hearing thresholds, respectively, than the subjects with a 677C allele.	Folic Acid	14-20	methylenetetrahydrofolate reductase	Homo sapiens	50-55
16464657-7	2006	The relationship between serum folate and hearing thresholds appeared to be dependent on MTHFR 677 genotype (CC, r = 0.13, p = 0.034; TT, r = -0.10, p = 0.291).	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	89-94
16679643-18	2006	Folate levels may modify the presentation of the MTHFR TT genotype.	Folic Acid	0-6	methylenetetrahydrofolate reductase	Homo sapiens	49-54
16442260-0	2006	Folic acid pretreatment prevents the reduction of Na(+),K(+)-ATPase and butyrylcholinesterase activities in rats subjected to acute hyperhomocysteinemia.	Folic Acid	0-10	butyrylcholinesterase	Rattus norvegicus	72-93
16442260-1	2006	The main objective of the present study was to evaluate the effect of folic acid pretreatment on parietal cortex Na(+),K(+)-ATPase and serum butyrylcholinesterase activities in rats subjected to acute hyperhomocysteinemia.	Folic Acid	70-80	butyrylcholinesterase	Rattus norvegicus	141-162
16442260-9	2006	The presented results confirm previous findings that acute hyperhomocysteinemia produces an inhibition of Na(+),K(+)-ATPase and butyrylcholinesterase activities and that pretreatment with folic acid prevents such effects.	Folic Acid	188-198	butyrylcholinesterase	Rattus norvegicus	128-149
16845898-7	2006	Addition of folic acid (200 ng/mL) to the culture medium abolished NADPH oxidase-dependent superoxide anion generation in macrophages by preventing phosphorylation of p47phox subunit.	Folic Acid	12-22	neutrophil cytosolic factor 1	Homo sapiens	167-174
17087642-2	2006	The methionine synthase reductase (MTRR) enzyme restores methionine synthase (MTR) enzyme activity and therefore plays an essential role in the folate- and vitamin B(12)-dependent remethylation of homocysteine to methionine.	Folic Acid	144-150	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	4-23
15935452-0	2006	Gene--nutrition interactions in coronary artery disease: correlation between the MTHFR C677T polymorphism and folate and homocysteine status in a Korean population.	Folic Acid	110-116	methylenetetrahydrofolate reductase	Homo sapiens	81-86
15935452-2	2006	Methyltetrahydrofolate reductase (MTHFR) is a main regulatory enzyme in homocysteine metabolism; a common C677T mutation in the MTHFR gene results in decreased enzyme activity, and contributes to increased homocysteine levels and decreased folate levels.	Folic Acid	16-22	methylenetetrahydrofolate reductase	Homo sapiens	34-39
15935452-2	2006	Methyltetrahydrofolate reductase (MTHFR) is a main regulatory enzyme in homocysteine metabolism; a common C677T mutation in the MTHFR gene results in decreased enzyme activity, and contributes to increased homocysteine levels and decreased folate levels.	Folic Acid	16-22	methylenetetrahydrofolate reductase	Homo sapiens	128-133
15935452-6	2006	We then defined the genotype-specific threshold values of folate and vitamin B12 required to keep homocysteine levels in a normal range for individuals of each MTHFR C677T genotype.	Folic Acid	58-64	methylenetetrahydrofolate reductase	Homo sapiens	160-165
15935452-11	2006	CONCLUSION: We were able to define a gene-nutrient interaction that shows a higher risk for CAD based on specific threshold folate levels required by different MTHFR C677T genotypes in a Korean population.	Folic Acid	124-130	methylenetetrahydrofolate reductase	Homo sapiens	160-165
16372906-5	2005	5,10-MTHFR is a key enzyme in the folate metabolism, diverting metabolites toward methylation reactions or nucleotide synthesis.	Folic Acid	34-40	methylenetetrahydrofolate reductase	Homo sapiens	5-10
16353542-4	2005	The prevalence of MTHFR variants (C677T and 677TT) was elevated in all ethnic groups (78% among the wayuu, 76% among Italians and 63% among mestizos) with a significant association between the concentrations of homocysteine and the levels of serum folate among the wayuu (p &lt; 0.0001) and the mestizos (p &lt; 0.001) only.	Folic Acid	248-254	methylenetetrahydrofolate reductase	Homo sapiens	18-23
16234003-9	2005	Among cancers with loss of an MTHFR allele, cancers with 677T MTHFR alleles had more deletions at folate-sensitive fragile sites (36.9%) and at tumor suppressor gene loci (68.5%) than 677C cancers (28.7% and 47.8%, P = .079 and .014, respectively).	Folic Acid	98-104	methylenetetrahydrofolate reductase	Homo sapiens	30-35
16234003-9	2005	Among cancers with loss of an MTHFR allele, cancers with 677T MTHFR alleles had more deletions at folate-sensitive fragile sites (36.9%) and at tumor suppressor gene loci (68.5%) than 677C cancers (28.7% and 47.8%, P = .079 and .014, respectively).	Folic Acid	98-104	methylenetetrahydrofolate reductase	Homo sapiens	62-67
16043029-0	2005	Uracil misincorporation into DNA of leukocytes of young women with positive folate balance depends on plasma vitamin B12 concentrations and methylenetetrahydrofolate reductase polymorphisms.	Folic Acid	76-82	methylenetetrahydrofolate reductase	Homo sapiens	140-175
16043029-10	2005	The concentration of folate in plasma correlated (P&lt;or=.05) with the wild-type MTHFR homozygote 1298 AA but not with the MTHFR 677 genotype.	Folic Acid	21-27	methylenetetrahydrofolate reductase	Homo sapiens	82-87
16043029-11	2005	When subjects were grouped according to genotype, the mean concentration of folate in plasma was significantly lower in subjects with the MTHFR 677 (CT+TT) polymorphism, which was accompanied by a lower UrMis, compared to individuals with the CC genotype.	Folic Acid	76-82	methylenetetrahydrofolate reductase	Homo sapiens	138-143
16043029-12	2005	The significantly higher concentrations of folate in serum, accompanied by increased UrMis, were seen in subjects with the combined MTHFR 1298 (AC+CC) genotype, as compared to the 1298 AA wild type.	Folic Acid	43-49	methylenetetrahydrofolate reductase	Homo sapiens	132-137
16096524-1	2005	Methylenetetrahydrofolate reductase (MTHFR) is an essential enzyme in folate metabolism and in DNA methylation and synthesis.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
16002814-2	2005	Folate metabolism may be altered by alcohol intake and 2 common polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, 677C--&gt;T and 1298A--&gt;C. OBJECTIVE: We examined whether the associations between folate intake and plasma folate and tHcy concentrations were modified by alcohol intake or variations in the MTHFR gene.	Folic Acid	0-6	methylenetetrahydrofolate reductase	Homo sapiens	85-120
16002814-2	2005	Folate metabolism may be altered by alcohol intake and 2 common polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, 677C--&gt;T and 1298A--&gt;C. OBJECTIVE: We examined whether the associations between folate intake and plasma folate and tHcy concentrations were modified by alcohol intake or variations in the MTHFR gene.	Folic Acid	0-6	methylenetetrahydrofolate reductase	Homo sapiens	122-127
16002814-2	2005	Folate metabolism may be altered by alcohol intake and 2 common polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, 677C--&gt;T and 1298A--&gt;C. OBJECTIVE: We examined whether the associations between folate intake and plasma folate and tHcy concentrations were modified by alcohol intake or variations in the MTHFR gene.	Folic Acid	0-6	methylenetetrahydrofolate reductase	Homo sapiens	330-335
16002814-2	2005	Folate metabolism may be altered by alcohol intake and 2 common polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, 677C--&gt;T and 1298A--&gt;C. OBJECTIVE: We examined whether the associations between folate intake and plasma folate and tHcy concentrations were modified by alcohol intake or variations in the MTHFR gene.	Folic Acid	104-110	methylenetetrahydrofolate reductase	Homo sapiens	122-127
16002814-2	2005	Folate metabolism may be altered by alcohol intake and 2 common polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, 677C--&gt;T and 1298A--&gt;C. OBJECTIVE: We examined whether the associations between folate intake and plasma folate and tHcy concentrations were modified by alcohol intake or variations in the MTHFR gene.	Folic Acid	221-227	methylenetetrahydrofolate reductase	Homo sapiens	85-120
16002814-2	2005	Folate metabolism may be altered by alcohol intake and 2 common polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, 677C--&gt;T and 1298A--&gt;C. OBJECTIVE: We examined whether the associations between folate intake and plasma folate and tHcy concentrations were modified by alcohol intake or variations in the MTHFR gene.	Folic Acid	221-227	methylenetetrahydrofolate reductase	Homo sapiens	122-127
16002818-10	2005	These data support the benefit of folic acid supplementation in pregnant women, particularly in those with MTHFR deficiency.	Folic Acid	34-44	methylenetetrahydrofolate reductase	Homo sapiens	107-112
16030402-3	2005	Methylenetetrahydrofolate reductase (MTHFR) plays a central role in converting folate to methyl donor for DNA methylation.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
15799025-9	2005	CONCLUSIONS: Our findings suggest that the RFC1 G allele is likely to be an important genetic factor in determining folate transport and subsequently may be a risk factor for NTDs in this Chinese population.	Folic Acid	116-122	replication factor C subunit 1	Homo sapiens	43-47
15846510-1	2005	The reduced-folate carrier (Rfc-1), previously also called methotrexate carrier-1 (MTX-1), was recently identified as accounting for approximately 30% of the methotrexate (Mtx) uptake into rat kidney slices.	Folic Acid	12-18	replication factor C subunit 1	Rattus norvegicus	28-33
15941959-1	2005	Methylenetetrahydrofolate reductase (MTHFR) catalyzes the metabolism of folate and nucleotides needed for DNA synthesis and repair.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
15870856-8	2005	Functional polymorphisms in folate-metabolizing genes, especially the methylenetetrahydrofolate reductase (MTHFR) are capable of modifying the risk of colorectal cancer.	Folic Acid	28-34	methylenetetrahydrofolate reductase	Homo sapiens	70-105
15870856-8	2005	Functional polymorphisms in folate-metabolizing genes, especially the methylenetetrahydrofolate reductase (MTHFR) are capable of modifying the risk of colorectal cancer.	Folic Acid	28-34	methylenetetrahydrofolate reductase	Homo sapiens	107-112
15870856-9	2005	Observational studies show that individuals with the homozygote genotype for the MTHFR (677C--&gt;T) polymorphism are at higher risk when folic acid supply is low.	Folic Acid	138-148	methylenetetrahydrofolate reductase	Homo sapiens	81-86
15952116-1	2005	OBJECTIVE: To search the interaction between reduced folate carrier gene (RFC1 A80G) polymorphism of children with neural tube defects (NTDs) and maternal periconceptional no supplementation of folic acid.	Folic Acid	194-204	replication factor C subunit 1	Homo sapiens	74-78
15952116-9	2005	CONCLUSION: The above findings indicate that the RFC1 genotype (GG) is a possible susceptible gene marker for an increased NTDs risk in Chinese population, and there is a potential gene-nutrient interaction between offspring RFC1 GG genotype and maternal periconceptional intake of folic acid on the risk of NTDs.	Folic Acid	282-292	replication factor C subunit 1	Homo sapiens	49-53
15952116-9	2005	CONCLUSION: The above findings indicate that the RFC1 genotype (GG) is a possible susceptible gene marker for an increased NTDs risk in Chinese population, and there is a potential gene-nutrient interaction between offspring RFC1 GG genotype and maternal periconceptional intake of folic acid on the risk of NTDs.	Folic Acid	282-292	replication factor C subunit 1	Homo sapiens	225-229
15800852-4	2005	In genetic NTD models such as Cart1, splotch, Cited2, and crooked tail, and NTD induced by teratogens including valproic acid and fumonisins, the incidence of defects is reduced by maternal folic acid supplementation.	Folic Acid	190-200	ALX homeobox 1	Mus musculus	30-35
15729744-3	2005	The MTHFR gene C677T polymorphism influences folate metabolism and intracellular availability of folate metabolites for methylation.	Folic Acid	45-51	methylenetetrahydrofolate reductase	Homo sapiens	4-9
15729744-3	2005	The MTHFR gene C677T polymorphism influences folate metabolism and intracellular availability of folate metabolites for methylation.	Folic Acid	97-103	methylenetetrahydrofolate reductase	Homo sapiens	4-9
15894672-1	2005	Methylenetetrahydrofolate reductase (MTHFR) is a key regulatory enzyme in the metabolism of folate, a nutrient that has been inversely related to colorectal cancer risk.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
15894672-2	2005	The common C677T variant in the MTHFR gene results in a reduced activity of this enzyme, thereby increasing the availability of folate for the production of thymidylate and purine for DNA synthesis and repair.	Folic Acid	128-134	methylenetetrahydrofolate reductase	Homo sapiens	32-37
15894672-10	2005	This study corroborates previous findings of an inverse association of the MTHFR 677TT genotype with colorectal cancer, especially at high levels of folate and low levels of ethanol intake.	Folic Acid	149-155	methylenetetrahydrofolate reductase	Homo sapiens	75-80
15865458-11	2005	This may be due to noncompliance with the folic acid recommendation and/or only a weak causal association between folic acid and smoking and occurrence of CL(P).	Folic Acid	114-124	coactosin like F-actin binding protein 1	Homo sapiens	155-160
15609319-1	2005	We studied the association between dietary folate and specific K-ras mutations in colon and rectal cancer in The Netherlands Cohort Study on diet and cancer.	Folic Acid	43-49	KRAS proto-oncogene, GTPase	Homo sapiens	63-68
15609319-6	2005	For rectal cancer, folate intake was associated with a decreased disease risk in men and was most pronounced for K-ras mutated tumors, whereas an increased association was observed for women.	Folic Acid	19-25	KRAS proto-oncogene, GTPase	Homo sapiens	113-118
15609319-9	2005	Our data suggest that the effect of folate on rectal cancer risk is different for men and women and depends on the K-ras mutation status of the tumor.	Folic Acid	36-42	KRAS proto-oncogene, GTPase	Homo sapiens	115-120
15840047-0	2005	Associations between MTHFR 1793G&gt;A and plasma total homocysteine, folate, and vitamin B in kidney transplant recipients.	Folic Acid	69-75	methylenetetrahydrofolate reductase	Homo sapiens	21-26
15782407-2	2005	Vitamin B(12) (as methylcobalamin) is a cofactor for methionine synthase, an enzyme that plays a key role in folate metabolism.	Folic Acid	109-115	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	53-72
15781665-3	2005	Methylenetetrahydrofolate reductase (MTHFR) is central to folate metabolism and has two common functional polymorphisms (C677T and A1298G).	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
15548731-2	2005	Within the folate pathway, methylenetetrahydrofolate reductase (MTHFR) reduces 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a methyl donor for remethylation of homocysteine to methionine, the precursor of S-adenosylmethionine.	Folic Acid	11-17	methylenetetrahydrofolate reductase	Homo sapiens	27-62
15548731-2	2005	Within the folate pathway, methylenetetrahydrofolate reductase (MTHFR) reduces 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a methyl donor for remethylation of homocysteine to methionine, the precursor of S-adenosylmethionine.	Folic Acid	11-17	methylenetetrahydrofolate reductase	Homo sapiens	64-69
15719048-11	2005	Homozygous mutation at MTHFR and MTHFD loci made serum folic acid and Vit.B(12) levels slightly decreased and serum Hcy level increased.	Folic Acid	55-65	methylenetetrahydrofolate reductase	Homo sapiens	23-28
15643524-2	2005	Methylenetetrahydrofolate reductase (MTHFR) is involved in folate metabolism and influences DNA methylation and nucleotide synthesis.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
15643524-3	2005	MTHFR is highly polymorphic and the variant genotypes result in decreased MTHFR enzyme activity and lower plasma folate level.	Folic Acid	113-119	methylenetetrahydrofolate reductase	Homo sapiens	0-5
15829374-1	2005	The aim of this study was to investigate the association of environmental factors (dietary folate, methionine and drinking status) and polymorphisms in the methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) gene, as well as the combination of these factors, with the risk of colon cancer and rectal cancer.	Folic Acid	91-97	methylenetetrahydrofolate reductase	Homo sapiens	156-191
15829374-1	2005	The aim of this study was to investigate the association of environmental factors (dietary folate, methionine and drinking status) and polymorphisms in the methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) gene, as well as the combination of these factors, with the risk of colon cancer and rectal cancer.	Folic Acid	91-97	methylenetetrahydrofolate reductase	Homo sapiens	193-198
15829374-8	2005	Adequate intake of folate was a protective factor from colon cancer (OR=0.32, 95% CI: 0.12-0.88) and MTHFR C677T polymorphism showed a statistically significant effect (OR=0.25, 95% CI: 0.06-0.93), reducing the risk of colon cancer in groups that have an intake of folate exceeding 115.64ng per 1000kcal per day.	Folic Acid	265-271	methylenetetrahydrofolate reductase	Homo sapiens	101-106
15829374-11	2005	There is a significant interaction between MTHFR C677T polymorphism and folate intake in reducing the risk of colon cancer.	Folic Acid	72-78	methylenetetrahydrofolate reductase	Homo sapiens	43-48
16045580-1	2005	SUMMARY: Methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS) are key enzymes in folate metabolism, which is essential for normal DNA methylation and synthesis.	Folic Acid	28-34	methylenetetrahydrofolate reductase	Homo sapiens	46-51
15585767-6	2004	Genotyping for the common methylenetetrahydrofolate reductase (MTHFR) 677C--&gt;T, MTHFR 1298A--&gt;C, cystathionine beta-synthase 844Ins68, methionine synthase 2756A--&gt;C, methionine synthase reductase 66A--&gt;G, and reduced folate carrier 80G--&gt;A polymorphisms was carried out.	Folic Acid	45-51	methylenetetrahydrofolate reductase	Homo sapiens	63-68
15510613-2	2004	Functional genetic variants in the methylene tetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS) genes may be risk factors for breast cancer because of their central roles in cellular folate metabolism.	Folic Acid	55-61	methylenetetrahydrofolate reductase	Homo sapiens	73-78
15117811-12	2004	Our results strongly suggest that polymorphisms of the MTHFR and MS genes act together with low folate intake and smoking to increase bladder cancer risk.	Folic Acid	96-102	methylenetetrahydrofolate reductase	Homo sapiens	55-60
15117811-12	2004	Our results strongly suggest that polymorphisms of the MTHFR and MS genes act together with low folate intake and smoking to increase bladder cancer risk.	Folic Acid	96-102	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	65-67
15342443-2	2004	We have investigated the relationships between two variants of the MTHFR gene (C677T and A1298C) and blood folate, homocysteine, and genomic stability (strand breakage, misincorporated uracil, and global cytosine methylation in lymphocytes) in a study of 199 subjects.	Folic Acid	107-113	methylenetetrahydrofolate reductase	Homo sapiens	67-72
15353309-6	2004	Although the mechanisms by which folic acid exerts its chemopreventive role in colorectal carcinogenesis remain to be fully elucidated, supplemental folic acid has been shown to arrest the loss of heterozygosity (LOH) of the tumor suppressor gene DCC (deleted in colorectal cancer) and to stabilize its protein in normal appearing rectal mucosa of patients with colorectal adenomas.	Folic Acid	149-159	DCC netrin 1 receptor	Homo sapiens	247-250
15353309-6	2004	Although the mechanisms by which folic acid exerts its chemopreventive role in colorectal carcinogenesis remain to be fully elucidated, supplemental folic acid has been shown to arrest the loss of heterozygosity (LOH) of the tumor suppressor gene DCC (deleted in colorectal cancer) and to stabilize its protein in normal appearing rectal mucosa of patients with colorectal adenomas.	Folic Acid	149-159	DCC netrin 1 receptor	Homo sapiens	252-280
15033905-1	2004	Methylenetetrahydrofolate reductase (MTHFR), a key enzyme in folate metabolism, plays a major role in the provision of methyl groups for DNA methylation and in the production of dTMP for DNA synthesis.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
15355664-8	2004	The MTHFR C667T polymorphism was associated with the concentration of plasma folic acid but not with the concentration of plasma homocysteine in both the case group and the control group.	Folic Acid	77-87	methylenetetrahydrofolate reductase	Homo sapiens	4-9
15355664-9	2004	The multiple correlation coefficient between the MTHFR C667T polymorphism and the concentration of plasma folic acid is 0.5856 (P &lt; 0.01).	Folic Acid	106-116	methylenetetrahydrofolate reductase	Homo sapiens	49-54
15210385-1	2004	PURPOSE: Methylenetetrahydrofolate reductase (MTHFR) is involved in the metabolism of folate and homocysteine; a polymorphism in the MTHFR gene (677C--&gt;T) has been associated with adverse outcomes of pregnancy.	Folic Acid	28-34	methylenetetrahydrofolate reductase	Homo sapiens	46-51
15210385-1	2004	PURPOSE: Methylenetetrahydrofolate reductase (MTHFR) is involved in the metabolism of folate and homocysteine; a polymorphism in the MTHFR gene (677C--&gt;T) has been associated with adverse outcomes of pregnancy.	Folic Acid	28-34	methylenetetrahydrofolate reductase	Homo sapiens	133-138
15136061-6	2004	Among smokers, the MTHFR 677TT genotype was significantly associated with high tHcy in heavy smokers (P = 0.003) but not light smokers (P = 0.09), in men (P = 0.003) but not women (P = 0.11), and in subjects from the lowest serum folate quartile (P = 0.49) but not from folate quartiles 2-4 (P = 0.49).	Folic Acid	230-236	methylenetetrahydrofolate reductase	Homo sapiens	19-24
15136061-6	2004	Among smokers, the MTHFR 677TT genotype was significantly associated with high tHcy in heavy smokers (P = 0.003) but not light smokers (P = 0.09), in men (P = 0.003) but not women (P = 0.11), and in subjects from the lowest serum folate quartile (P = 0.49) but not from folate quartiles 2-4 (P = 0.49).	Folic Acid	270-276	methylenetetrahydrofolate reductase	Homo sapiens	19-24
15136061-8	2004	We propose that hyperhomocysteinemia in MTHFR 677TT homozygote smokers is the consequence of mild intracellular folate deficiency caused by a smoking-related reduction of NOS3 activity that is exacerbated when serum folate is low.	Folic Acid	112-118	methylenetetrahydrofolate reductase	Homo sapiens	40-45
15211708-4	2004	canalicular multispecific organic anion transporter [cMOAT], multidrug resistance related protein 2 [MRP2]), a member of the ABC transporter family that effluxes natural folates and anti-folate drugs such as methotrexate.	Folic Acid	170-177	ATP binding cassette subfamily C member 2	Homo sapiens	0-51
15211708-4	2004	canalicular multispecific organic anion transporter [cMOAT], multidrug resistance related protein 2 [MRP2]), a member of the ABC transporter family that effluxes natural folates and anti-folate drugs such as methotrexate.	Folic Acid	170-177	ATP binding cassette subfamily C member 2	Homo sapiens	53-58
15211708-4	2004	canalicular multispecific organic anion transporter [cMOAT], multidrug resistance related protein 2 [MRP2]), a member of the ABC transporter family that effluxes natural folates and anti-folate drugs such as methotrexate.	Folic Acid	170-176	ATP binding cassette subfamily C member 2	Homo sapiens	0-51
15211708-4	2004	canalicular multispecific organic anion transporter [cMOAT], multidrug resistance related protein 2 [MRP2]), a member of the ABC transporter family that effluxes natural folates and anti-folate drugs such as methotrexate.	Folic Acid	170-176	ATP binding cassette subfamily C member 2	Homo sapiens	53-58
15103709-3	2004	In this study, we examined the two polymorphisms in genes encoding the folate metabolizing enzyme methylenetetrahydrofolate reductase (MTHFR), namely, 677C &gt; T and 1298A &gt; C. The prevalence of these variant genotypes in mothers of DS children (case mothers) (n = 152) was compared with controls (n = 91).	Folic Acid	71-77	methylenetetrahydrofolate reductase	Homo sapiens	98-133
15103709-3	2004	In this study, we examined the two polymorphisms in genes encoding the folate metabolizing enzyme methylenetetrahydrofolate reductase (MTHFR), namely, 677C &gt; T and 1298A &gt; C. The prevalence of these variant genotypes in mothers of DS children (case mothers) (n = 152) was compared with controls (n = 91).	Folic Acid	71-77	methylenetetrahydrofolate reductase	Homo sapiens	135-140
15044114-5	2004	In the regression equation ( y= ax + b) of serum folate ( y nmol/L) plotted against mean folate intake ( x microg/day), the values of "a" were 0.032, 0.037, and 0.045 for individuals with CC, CT, and TT alleles, respectively, of MTHFR.	Folic Acid	49-55	methylenetetrahydrofolate reductase	Homo sapiens	229-234
20396547-7	2004	The protective effect of the homozygous variant TT form of the MTHFR genotype on the risk of colon cancer seems to be modified by the level of methyl diets, i.e., by folate, which has a protective effect, or conversely by alcohol.	Folic Acid	166-172	methylenetetrahydrofolate reductase	Homo sapiens	63-68
14722319-4	2004	Folate and benzylpenicillin (PCG) inhibited the uptake by 30 to 40% and 40 to 50% of the total saturable uptake of MTX by kidney slices, respectively, whereas the effect of p-aminohippurate (PAH) was minimal at the concentration selective for rOat1.	Folic Acid	0-6	solute carrier family 22 member 6	Rattus norvegicus	243-248
15161007-1	2004	BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) plays a critical role in folate metabolism, which is an important pathway of the methyl donor for DNA methylation.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	49-54
15161007-3	2004	Impaired folate metabolism by these genetic variants of MTHFR could change the methylation pattern of DNA including promoter hypermethylation, which has been frequently observed in cancer.	Folic Acid	9-15	methylenetetrahydrofolate reductase	Homo sapiens	56-61
15040829-0	2004	Association of a common polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene with bone phenotypes depends on plasma folate status.	Folic Acid	63-69	methylenetetrahydrofolate reductase	Homo sapiens	81-86
15040829-2	2004	Our findings support the hypothesis that the association between an MTHFR polymorphism and bone phenotypes depends on folate status.	Folic Acid	118-124	methylenetetrahydrofolate reductase	Homo sapiens	68-73
15040829-4	2004	Individuals homozygous (TT) for the MTHFR C677T polymorphism who have low plasma folate concentrations exhibit elevated plasma homocysteine (tHcy) concentrations that may compromise bone quality.	Folic Acid	81-87	methylenetetrahydrofolate reductase	Homo sapiens	36-41
15040829-15	2004	CONCLUSIONS: Our findings support the hypothesis that the association between the C677T MTHFR polymorphism and bone phenotypes depends on folate status.	Folic Acid	138-144	methylenetetrahydrofolate reductase	Homo sapiens	88-93
14743434-0	2004	Increased transcription and activity of glutathione synthase in response to deficiencies in folate, vitamin E, and apolipoprotein E.	Folic Acid	92-98	glutathione synthetase	Mus musculus	40-60
14973091-10	2004	Results of this study suggest that the MTHFR C677T polymorphisms may modify the association between dietary folate intake and breast cancer risk.	Folic Acid	108-114	methylenetetrahydrofolate reductase	Homo sapiens	39-44
14973104-1	2004	5,10-methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism, diverting metabolites toward methylation reactions or nucleotide synthesis.	Folic Acid	24-30	methylenetetrahydrofolate reductase	Homo sapiens	42-47
14973104-7	2004	Stratification by nutrient intakes showed inverse associations with higher intakes of folate, vitamin B(2), B(6), B(12), and methionine among women with the MTHFR 677CC/1298AA genotypes, but not those with 677TT/1298AA.	Folic Acid	86-92	methylenetetrahydrofolate reductase	Homo sapiens	157-162
14734201-0	2004	Methylenetetrahydrofolate reductase (MTHFR) c677t gene variant modulates the homocysteine folate correlation in a mild folate-deficient population.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
14734201-3	2004	We investigated the influence of methylenetetrahydrofolate reductase (MTHFR) gene variants C677T, A1298C, and T1317C on homocysteine, folate, and cobalamin concentrations in a sample of individuals from a mild folate deficiency population to better clarify the complex interactions existing among these variables.	Folic Acid	52-58	methylenetetrahydrofolate reductase	Homo sapiens	70-75
14734201-11	2004	One may consider that a differential response of homocysteine to folic acid supplementation may depend on MTHFR genotype which may have important implications when attempting to lower homocysteine concentrations in populations with mild folate deficiency.	Folic Acid	65-75	methylenetetrahydrofolate reductase	Homo sapiens	106-111
14717604-1	2004	Human methionine synthase reductase (MSR) is a key enzyme in folate and methionine metabolism as it reactivates the catalytically inert cob(II)alamin form of methionine synthase (MS).	Folic Acid	61-67	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	6-25
15207432-3	2004	Both the MTHFR 677C--&gt;T and the 1298A--&gt;C polymorphisms are associated with mild hyperhomocysteinemia, particularly in conditions of low folate status.	Folic Acid	143-149	methylenetetrahydrofolate reductase	Homo sapiens	9-14
12958073-1	2004	The central role of methylenetetrahydrofolate reductase (MTHFR) in the folate metabolism renders MTHFR gene polymorphisms (C677T and A1298C) potential modulators of a variety of disorders whose development depends on folate/homocysteine imbalance.	Folic Acid	39-45	methylenetetrahydrofolate reductase	Homo sapiens	57-62
12958073-1	2004	The central role of methylenetetrahydrofolate reductase (MTHFR) in the folate metabolism renders MTHFR gene polymorphisms (C677T and A1298C) potential modulators of a variety of disorders whose development depends on folate/homocysteine imbalance.	Folic Acid	39-45	methylenetetrahydrofolate reductase	Homo sapiens	97-102
12958073-1	2004	The central role of methylenetetrahydrofolate reductase (MTHFR) in the folate metabolism renders MTHFR gene polymorphisms (C677T and A1298C) potential modulators of a variety of disorders whose development depends on folate/homocysteine imbalance.	Folic Acid	71-77	methylenetetrahydrofolate reductase	Homo sapiens	20-55
12958073-1	2004	The central role of methylenetetrahydrofolate reductase (MTHFR) in the folate metabolism renders MTHFR gene polymorphisms (C677T and A1298C) potential modulators of a variety of disorders whose development depends on folate/homocysteine imbalance.	Folic Acid	71-77	methylenetetrahydrofolate reductase	Homo sapiens	57-62
12958073-1	2004	The central role of methylenetetrahydrofolate reductase (MTHFR) in the folate metabolism renders MTHFR gene polymorphisms (C677T and A1298C) potential modulators of a variety of disorders whose development depends on folate/homocysteine imbalance.	Folic Acid	71-77	methylenetetrahydrofolate reductase	Homo sapiens	97-102
12958073-5	2004	Further stratification in patients born before and after January 1996 (approximate time of Health Canada recommendation for folic acid supplement in pregnancy) revealed that the protective effect of MTHFR variants is accentuated and present only in children born before 1996.	Folic Acid	124-134	methylenetetrahydrofolate reductase	Homo sapiens	199-204
15490719-13	2004	CD8 counts were higher in women with low serum folate (87; 95% CI, 6 to 166 cells/L; p = 0.036) and were slightly higher in gravida 4+ compared to gravida one to three.	Folic Acid	47-53	CD8a molecule	Homo sapiens	0-3
15633292-0	2004	Folate supplementation reduces serum hsp70 levels in patients with type 2 diabetes.	Folic Acid	0-6	heat shock protein family A (Hsp70) member 4	Homo sapiens	37-42
15633292-2	2004	The aim of this study was to determine whether administration of the antioxidant folic acid, previously shown to reduce homocysteine levels, would reduce circulating levels of Hsp70 while improving the condition of type 2 diabetes patients with microalbuminuria.	Folic Acid	81-91	heat shock protein family A (Hsp70) member 4	Homo sapiens	176-181
15633292-6	2004	Folic acid supplementation resulted in a significant fall in Hsp70 (5.32 to 2.05 ng/mL) (P = 0.004).	Folic Acid	0-10	heat shock protein family A (Hsp70) member 4	Homo sapiens	61-66
15633292-8	2004	Folic acid supplementation in non-insulin-treated type 2 diabetes patients, therefore, resulted in a fall in Hsp70, reflecting an improvement in oxidative stress.	Folic Acid	0-10	heat shock protein family A (Hsp70) member 4	Homo sapiens	109-114
14679361-9	2004	Serum homocysteine was negatively correlated with serum folate in all MTHFR genotypes (P&lt;0.001), and the correlation between the two serum levels was the strongest in the T/T genotype.	Folic Acid	56-62	methylenetetrahydrofolate reductase	Homo sapiens	70-75
14679361-10	2004	Serum homocysteine was higher in the subjects with the T/T MTHFR genotype only when the serum folate was below the median level.	Folic Acid	94-100	methylenetetrahydrofolate reductase	Homo sapiens	59-64
14679361-13	2004	Higher serum folate, vitamin B2, and vitamin B12 concentrations may lessen the MTHFR genotypic effect on serum homocysteine levels.	Folic Acid	13-19	methylenetetrahydrofolate reductase	Homo sapiens	79-84
15970629-1	2004	Hyperhomocysteinemia can result from decreased methylenetetrahydrofolate reductase (MTHFR) enzyme activity, owing to genetic polymorphisms andor inadequate folate intake.	Folic Acid	66-72	methylenetetrahydrofolate reductase	Homo sapiens	84-89
14663048-1	2003	OBJECTIVE: To evaluate whether hyperhomocysteinemia is an independent risk factor for silent brain infarction (SBI), and to determine the relationship between homocysteine and folate in each type of methylenetetrahydrofolate reductase (MTHFR) polymorphism, in order to identify a way of reducing the risk for SBI.	Folic Acid	176-182	methylenetetrahydrofolate reductase	Homo sapiens	199-234
14663048-5	2003	The homocysteine level showed a significant inverse correlation with folate level only in patients with SBI with the MTHFR 677TT genotype (p &lt; 0.05).	Folic Acid	69-75	methylenetetrahydrofolate reductase	Homo sapiens	117-122
14663048-6	2003	CONCLUSIONS: This study demonstrates that hyperhomocysteinemia is an independent risk factor for SBI, and provides the possibility of reducing the risk for SBI in the MTHFR 677TT genotype by folate supplementation.	Folic Acid	191-197	methylenetetrahydrofolate reductase	Homo sapiens	167-172
14676107-0	2003	The folate pool in colorectal cancers is associated with DNA hypermethylation and with a polymorphism in methylenetetrahydrofolate reductase.	Folic Acid	4-10	methylenetetrahydrofolate reductase	Homo sapiens	105-140
14690253-8	2003	In contrast, in RTR similar doses of folic acid normalizes homocysteine.	Folic Acid	37-47	nuclear receptor subfamily 6 group A member 1	Homo sapiens	16-19
12684695-2	2003	Thymidylate synthase (TS) and methylenetetrahydrofolate reductase (MTHFR) are key enzymes in the folate metabolism and both have been shown to be polymorphic affecting the enzyme activity.	Folic Acid	49-55	methylenetetrahydrofolate reductase	Homo sapiens	67-72
12707400-1	2003	This study was designed to examine the effect of two single nucleotide polymorphisms in the reduced folate carrier 1 (RFC1 80G&gt;A) and the glutamate carboxypeptidase 2 (GCP2 1561C&gt;T) gene on total homocysteine (tHcy) plasma level and folate status in 120 chronic dialysis patients.	Folic Acid	100-106	replication factor C subunit 1	Homo sapiens	118-122
12672677-5	2003	Mothers carrying the MTHFR 677TT genotype and who either did not use folic acid supplements periconceptionally or had a low dietary folate intake, or both, had an increased risk of delivering a CL(P) child (odds ratio (OR) = 5.9, 95% confidence interval (CI): 1.1, 30.9; OR = 2.8, 95% CI: 0.7, 10.5; OR = 10.0, 95% CI: 1.3, 79.1, respectively).	Folic Acid	132-138	methylenetetrahydrofolate reductase	Homo sapiens	21-26
12672677-7	2003	Thus, the detrimental effect of low periconceptional folate intake on the risk of giving birth to a CL(P) child was more pronounced in mothers with the MTHFR 677TT or MTHFR 1298CC genotype.	Folic Acid	53-59	methylenetetrahydrofolate reductase	Homo sapiens	152-157
12672677-7	2003	Thus, the detrimental effect of low periconceptional folate intake on the risk of giving birth to a CL(P) child was more pronounced in mothers with the MTHFR 677TT or MTHFR 1298CC genotype.	Folic Acid	53-59	methylenetetrahydrofolate reductase	Homo sapiens	167-172
12651974-3	2003	A common 677C--&gt;T mutation in the MTHFR gene results in decreased enzymic activity, and contributes to increased plasma tHcy, in association with low plasma folate.	Folic Acid	160-166	methylenetetrahydrofolate reductase	Homo sapiens	37-42
12627958-5	2003	We find that hCRY2 exhibits fluorescence properties consistent with the presence of folate and flavin cofactors.	Folic Acid	84-90	cryptochrome circadian regulator 2	Homo sapiens	13-18
12628490-0	2003	The role of multidrug resistance proteins MRP1, MRP2 and MRP3 in cellular folate homeostasis.	Folic Acid	74-80	ATP binding cassette subfamily C member 2	Homo sapiens	48-52
12628490-3	2003	In MRP1, MRP2 and MRP3-transfected 2008 human ovarian carcinoma cells total cellular folate content was 32-38% lower than in 2008 cells (105+/-14pmolfolate/mgprotein) when grown in medium containing 2.3 microM folic acid (FA).	Folic Acid	85-91	ATP binding cassette subfamily C member 2	Homo sapiens	9-13
12784029-4	2003	OBJECTIVE: To analyse the correlation between the ApoE and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and plasma homocysteine levels and vitamins (B(12) and folic acid) concentrations in serum from patients with AD and mild cognitive impairment (MCI) as compared with control group.	Folic Acid	177-187	methylenetetrahydrofolate reductase	Homo sapiens	96-101
12784029-9	2003	RESULTS: We found that plasma total homocysteine is increased in AD patients (p < 0.0001) and depended on the MTHFR T/T genotype in the presence of low folate levels (p < 0.05).	Folic Acid	152-158	methylenetetrahydrofolate reductase	Homo sapiens	110-115
15068389-1	2003	BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) plays a critical role in folate metabolism and displays common genetic polymorphisms affecting the enzyme activity.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	49-54
12453860-1	2002	BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, a common mutation of the gene encoding the enzyme that catalyzes reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a carbon donor in the metabolism of folate, determines a striking reduction in the enzyme activity in carriers of mutation at homozygous status.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	49-54
12496052-9	2002	Our results suggest that variation at MTHFR codon 1298 (within the COOH-terminal region) may be more important for colon cancer than variation at codon 677 (NH(2)-terminal region), and in populations where folate intake is low, wild-type MTHFR activity may increase risk for colon cancer.	Folic Acid	206-212	methylenetetrahydrofolate reductase	Homo sapiens	38-43
12416982-2	2002	This reaction is of paramount physiological importance since methionine synthase is an essential enzyme that plays a key role in the methionine and folate cycles.	Folic Acid	148-154	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	61-80
12384833-2	2002	A variant form of methylenetetrahydrofolate reductase (MTHFR) (677C--&gt;T) is a known risk factor for NTDs, but the prevalence of the risk genotype explains only a small portion of the protective effect of folic acid.	Folic Acid	207-217	methylenetetrahydrofolate reductase	Homo sapiens	18-53
12384833-2	2002	A variant form of methylenetetrahydrofolate reductase (MTHFR) (677C--&gt;T) is a known risk factor for NTDs, but the prevalence of the risk genotype explains only a small portion of the protective effect of folic acid.	Folic Acid	207-217	methylenetetrahydrofolate reductase	Homo sapiens	55-60
12810987-5	2002	Ones of those are genes of metabolism of folic acid as MTHFR, MTR, MTRR, CBS, MTHFD, folic acid receptors (FR) regulator genes from PAX family, T, PDGFRA and BRCA1 genes.	Folic Acid	41-51	methylenetetrahydrofolate reductase	Homo sapiens	55-60
12810987-5	2002	Ones of those are genes of metabolism of folic acid as MTHFR, MTR, MTRR, CBS, MTHFD, folic acid receptors (FR) regulator genes from PAX family, T, PDGFRA and BRCA1 genes.	Folic Acid	41-51	BRCA1 DNA repair associated	Homo sapiens	158-163
12396629-3	2002	To test this hypothesis, we constructed replication-defective retroviruses containing the murine-reduced folate carrier (mRFC).	Folic Acid	105-111	solute carrier family 19 (folate transporter), member 1	Mus musculus	121-125
12175537-1	2002	Methylenetetrahydrofolate reductase (MTHFR) plays a pivotal role in folate metabolism by regulating the diversion of folate metabolites toward DNA methylation or toward DNA synthesis.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
12175537-1	2002	Methylenetetrahydrofolate reductase (MTHFR) plays a pivotal role in folate metabolism by regulating the diversion of folate metabolites toward DNA methylation or toward DNA synthesis.	Folic Acid	68-74	methylenetetrahydrofolate reductase	Homo sapiens	0-35
12175537-1	2002	Methylenetetrahydrofolate reductase (MTHFR) plays a pivotal role in folate metabolism by regulating the diversion of folate metabolites toward DNA methylation or toward DNA synthesis.	Folic Acid	68-74	methylenetetrahydrofolate reductase	Homo sapiens	37-42
12175537-4	2002	Thus, rapid identification of both polymorphisms in MTHFR gene would be of importance in understanding the genetics of abnormal folate metabolism as related to human cancer risk.	Folic Acid	128-134	methylenetetrahydrofolate reductase	Homo sapiens	52-57
12430180-2	2002	The methylenetetrahydrofolate reductase gene (MTHFR), which has a key role in folate metabolism, is polymorphic.	Folic Acid	23-29	methylenetetrahydrofolate reductase	Homo sapiens	46-51
12430180-3	2002	We report a case-control study of two functional polymorphisms in MTHFR, dietary folate intake and breast cancer.	Folic Acid	81-87	methylenetetrahydrofolate reductase	Homo sapiens	66-71
12081832-0	2002	Methylenetetrahydrofolate reductase 677C--&gt;T genotype modulates homocysteine responses to a folate-rich diet or a low-dose folic acid supplement: a randomized controlled trial.	Folic Acid	126-136	methylenetetrahydrofolate reductase	Homo sapiens	0-35
12049616-8	2002	TT homozygosity at residue 677 was associated with elevation of total erythrocyte folate compared with both other genotypes (P&lt;0.0001), almost certainly due to the diversion of 5,10-methylenetetrahydrofolate into derivates subsequent to the partial metabolic block that results from the MTHFR enzyme defect.	Folic Acid	82-88	methylenetetrahydrofolate reductase	Homo sapiens	290-295
12049616-10	2002	The MTHFR genotype does not significantly influence either plasma homocysteine or vascular disease, despite it being a determinant of erythrocyte folate, which reflects its effect on folate metabolism.	Folic Acid	146-152	methylenetetrahydrofolate reductase	Homo sapiens	4-9
12049616-10	2002	The MTHFR genotype does not significantly influence either plasma homocysteine or vascular disease, despite it being a determinant of erythrocyte folate, which reflects its effect on folate metabolism.	Folic Acid	183-189	methylenetetrahydrofolate reductase	Homo sapiens	4-9
12090040-6	2002	These results suggest that the reduction of DPD activity is associated with the elevation of TS content, which may be connected with the development of 5-FU resistance and the effectiveness of biochemical modulation through the stabilization of TS inhibition with folic acid in colon carcinoma.	Folic Acid	264-274	dihydropyrimidine dehydrogenase	Homo sapiens	44-47
11950713-7	2002	(3) The oxidized low density lipoprotein-induced release of ENA-78 from peripheral blood mononuclear cells from control subjects was significantly reduced when cells were incubated in the presence of folic acid.	Folic Acid	200-210	C-X-C motif chemokine ligand 5	Homo sapiens	60-66
11925474-7	2002	Subjects with the MTHFR C677T homozygous variant (TT) genotype had a nonsignificantly lower risk, and risk patterns tended to differ by level of folate, methionine, alcohol intake and smoking, although the power to detect significant associations in subgroups of these variables was low.	Folic Acid	145-151	probable methylenetetrahydrofolate reductase	Nicotiana tabacum	18-23
11927833-1	2002	5,10-Methylenetetrahydrofolate reductase (MTHFR), a key enzyme involved in folate metabolism, has two common polymorphisms that affect enzyme activity.	Folic Acid	24-30	methylenetetrahydrofolate reductase	Homo sapiens	42-47
11823591-2	2002	The C677T MTHFR polymorphism is associated with mild hyperhomocysteinemia, but only in the presence of low folate status.	Folic Acid	107-113	methylenetetrahydrofolate reductase	Homo sapiens	10-15
11918280-7	2001	Moreover, patients with MTHFR A/A genotype showed a poorer folate status than control subjects, suggesting that a subclinical folate deficiency may be very frequent in renal artery stenosis, regardless of C677T mutation.	Folic Acid	59-65	methylenetetrahydrofolate reductase	Homo sapiens	24-29
11918280-7	2001	Moreover, patients with MTHFR A/A genotype showed a poorer folate status than control subjects, suggesting that a subclinical folate deficiency may be very frequent in renal artery stenosis, regardless of C677T mutation.	Folic Acid	126-132	methylenetetrahydrofolate reductase	Homo sapiens	24-29
11738277-3	2001	Individuals homozygous (TT) for the C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene ( approximately 12% of the population) have increased homocysteine levels, particularly in association with suboptimal folate intake.	Folic Acid	77-83	methylenetetrahydrofolate reductase	Homo sapiens	95-100
11600421-2	2001	Studies with intestinal epithelial cells have suggested that this activity is mediated by the reduced folate carrier (RFC1).	Folic Acid	102-108	replication factor C subunit 1	Rattus norvegicus	118-122
11600421-4	2001	Transfection of this cell line with an RFC1 construct resulted in clones exhibiting increased MTX uptake at both the pHs and high folic acid uptake only at the low pH.	Folic Acid	130-140	replication factor C subunit 1	Rattus norvegicus	39-43
11686575-3	2001	Folate is the strongest nutritional and pharmacological determinant of plasma homocysteine concentrations, which also interact with the genetic variation in methylenetetrahydrofolate reductase (MTHFR).	Folic Acid	0-6	methylenetetrahydrofolate reductase	Homo sapiens	157-192
11686575-3	2001	Folate is the strongest nutritional and pharmacological determinant of plasma homocysteine concentrations, which also interact with the genetic variation in methylenetetrahydrofolate reductase (MTHFR).	Folic Acid	0-6	methylenetetrahydrofolate reductase	Homo sapiens	194-199
11305908-3	2001	Cytoplasmic SHMT (cSHMT) has been postulated to channel one-carbon substituted folates to various folate-dependent enzymes, and alternative splicing of the cSHMT transcript may be a mechanism that enables specific protein-protein interactions.	Folic Acid	79-86	serine hydroxymethyltransferase 1 (soluble)	Mus musculus	12-16
11305908-3	2001	Cytoplasmic SHMT (cSHMT) has been postulated to channel one-carbon substituted folates to various folate-dependent enzymes, and alternative splicing of the cSHMT transcript may be a mechanism that enables specific protein-protein interactions.	Folic Acid	79-85	serine hydroxymethyltransferase 1 (soluble)	Mus musculus	12-16
11295154-2	2001	This activity is compromised when Vitamin B12 (B12) concentration is low because methionine synthase activity is reduced, lowering the concentration of S-adenosyl methionine (SAM) which in turn may diminish DNA methylation and cause folate to become unavailable for the conversion of dUMP to dTMP.	Folic Acid	233-239	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	81-100
11309278-1	2001	Methylenetetrahydrofolate reductase (MTHFR) plays a central role in folate metabolism that affects DNA methylation and synthesis.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
11337744-5	2001	We suggest that homozygosity for the MTHFR mutation may be a risk factor for transverse terminal limb defect/s by an effect mediated through altered folate and homocysteine metabolism.	Folic Acid	149-155	methylenetetrahydrofolate reductase	Homo sapiens	37-42
11319182-2	2001	Methylene-tetrahydrofolate reductase (MTHFR) is one of the enzymes involved in folate metabolism and is thought to influence DNA methylation and nucleotide synthesis.	Folic Acid	20-26	methylenetetrahydrofolate reductase	Homo sapiens	38-43
11319182-3	2001	MTHFR is highly polymorphic, and the variant genotypes result in decreased MTHFR enzyme activity and lower plasma folate level.	Folic Acid	114-120	methylenetetrahydrofolate reductase	Homo sapiens	0-5
11368417-7	2001	Thus, a dysfunctional MTHFR partly explains the observed elevated Hcy levels in women with NTD pregnancies and also, in part, the protective effect of folate on NTD.	Folic Acid	151-157	methylenetetrahydrofolate reductase	Homo sapiens	22-27
11508713-3	2001	Since bile secretion of reduced folates reflects the activity of DHFR for PteGlu in the body, the bile secretion rates of reduced folates including tetrahydrofolate (H4PteGlu), 5-methyltetrahydrofolate, 5,10-methylenetetrahydrofolate, and 10-formyltetrahydrofolate were determined by using high-performance liquid chromatography with electrochemical detection, after the intravenous injection of PteGlu at 1 mg/kg body weight to pigs and rats.	Folic Acid	74-80	dihydrofolate reductase	Sus scrofa	65-69
11508713-0	2001	Comparison of dihydrofolate reductase activities for folic acid in pigs and rats using in vivo and in vitro evaluation techniques.	Folic Acid	53-63	dihydrofolate reductase	Sus scrofa	14-37
11508713-1	2001	The activity of dihydrofolate reductase (DHFR) for folic acid (PteGlu) was evaluated in pigs by in vivo and in vitro experiments.	Folic Acid	51-61	dihydrofolate reductase	Sus scrofa	16-39
11508713-1	2001	The activity of dihydrofolate reductase (DHFR) for folic acid (PteGlu) was evaluated in pigs by in vivo and in vitro experiments.	Folic Acid	51-61	dihydrofolate reductase	Sus scrofa	41-45
11508713-1	2001	The activity of dihydrofolate reductase (DHFR) for folic acid (PteGlu) was evaluated in pigs by in vivo and in vitro experiments.	Folic Acid	63-69	dihydrofolate reductase	Sus scrofa	16-39
11508713-1	2001	The activity of dihydrofolate reductase (DHFR) for folic acid (PteGlu) was evaluated in pigs by in vivo and in vitro experiments.	Folic Acid	63-69	dihydrofolate reductase	Sus scrofa	41-45
11282420-1	2001	The enzyme methylenetetrahydrofolate reductase (MTHFR) directs folate species either to DNA synthesis or to homocysteine (Hcy) remethylation.	Folic Acid	30-36	methylenetetrahydrofolate reductase	Homo sapiens	48-53
11282420-2	2001	The common MTHFR C677T polymorphism affects the activity of the enzyme and hence folate distribution.	Folic Acid	81-87	methylenetetrahydrofolate reductase	Homo sapiens	11-16
11282420-4	2001	The MTHFR C677T polymorphism shows no consistent correlation with cardiovascular risk and longevity but, in combination with positive folate balance, the TT genotype is associated with decreased risk of colorectal neoplasias.	Folic Acid	134-140	methylenetetrahydrofolate reductase	Homo sapiens	4-9
11157318-9	2001	Among individuals with low plasma folate, those possessing 2 copies of MTHFR mutant alleles had significantly higher homocysteine concentrations than did those with &gt; or = 1 copy of the wild-type allele.	Folic Acid	34-40	methylenetetrahydrofolate reductase	Homo sapiens	71-76
11261364-5	2001	There are recent reports that folic acid metabolism is also altered by other hereditary variations of MTHFR and other enzymes involved in folic acid metabolism.	Folic Acid	30-40	methylenetetrahydrofolate reductase	Homo sapiens	102-107
11261364-5	2001	There are recent reports that folic acid metabolism is also altered by other hereditary variations of MTHFR and other enzymes involved in folic acid metabolism.	Folic Acid	138-148	methylenetetrahydrofolate reductase	Homo sapiens	102-107
14728017-12	2001	However, hyperhomocysteinemia because of the C677T MTHFR allele may be corrected with oral folic acid therapy.	Folic Acid	91-101	methylenetetrahydrofolate reductase	Homo sapiens	51-56
11205486-9	2001	These findings have been bolstered by an association between incidence of colon cancer and a polymorphism in the gene for methylenetetrahydrofolate reductase, an enzyme involved in folic acid metabolism.	Folic Acid	181-191	methylenetetrahydrofolate reductase	Homo sapiens	122-157
11680544-2	2001	Methylenetetrahydrofolate reductase (MT-HFR) is a key enzyme involved in folate metabolism.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-43
11920232-2	2001	Several polymorphisms of genes encoding for enzymes acting in the remethylation pathway of homocysteine metabolism, ie, methionine synthase (MS) A2756G, methylenetetrahydrofolate reductase (MTHFR) C677T and MTHFR A1298C, can cause increased homocysteine levels particularly in patients with deficiencies of folic acid, vitamin B6, or B12 and hence be potential risk factors for VTE.	Folic Acid	307-317	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	120-139
11468972-1	2001	Methylenetetrahydrofolate reductase (MTHFR), is a cytosolic enzyme, the product of which is N5-metyltetrahydrofolate, the main form of folates in tissues and the carbon donor for methylation of homocysteine to methionine.	Folic Acid	135-142	methylenetetrahydrofolate reductase	Homo sapiens	0-35
11468972-1	2001	Methylenetetrahydrofolate reductase (MTHFR), is a cytosolic enzyme, the product of which is N5-metyltetrahydrofolate, the main form of folates in tissues and the carbon donor for methylation of homocysteine to methionine.	Folic Acid	135-142	methylenetetrahydrofolate reductase	Homo sapiens	37-42
11204591-9	2001	This interaction between CBS genotype and MTHFR and MS genotype points to a key role of the CBS transulphuration pathway in the metabolism of homocysteine that may be particularly important as a compensatory mechanism in subjects with low dietary folate.	Folic Acid	247-253	methylenetetrahydrofolate reductase	Homo sapiens	42-47
11204591-9	2001	This interaction between CBS genotype and MTHFR and MS genotype points to a key role of the CBS transulphuration pathway in the metabolism of homocysteine that may be particularly important as a compensatory mechanism in subjects with low dietary folate.	Folic Acid	247-253	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	52-54
16011963-1	2005	Plasma homocysteine levels depend in part on the molecular nature of the methylenetetrahydrofolate reductase (MTHFR) and on blood folate intake.	Folic Acid	92-98	methylenetetrahydrofolate reductase	Homo sapiens	110-115
15824167-1	2005	Methylenetetrahydrofolate reductase (MTHFR) balances the pool of folate coenzymes in one-carbon metabolism for DNA synthesis and methylation, both implicated in carcinogenesis.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
15824167-3	2005	We aimed to analyze lymphocyte DNA from 198 subjects to evaluate the MTHFR 1298A&gt;C polymorphism and folate status affecting genomic DNA methylation as a possible mechanism underlying the relationship between MTHFR polymorphisms and cancer susceptibility.	Folic Acid	103-109	methylenetetrahydrofolate reductase	Homo sapiens	211-216
15726099-3	2005	Methylenetetrahydrofolate reductase (MTHFR 677C --&gt; T and 1298A --&gt; C), methionine synthase (MS 2756A --&gt; G) and cystathionine synthase (CBS 844ins68) polymorphisms were measured to account for potential confounding effects on folate status and DNA methylation.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
15777680-6	2005	We have, therefore, reviewed baseline food record data from our original study to determine if BMD and fracture associations with the MTHFR genotype depended on the intake of folate, riboflavin, or other members of the vitamin B complex, associated with homocysteine metabolism.	Folic Acid	175-181	methylenetetrahydrofolate reductase	Homo sapiens	134-139
15777680-13	2005	In conclusion, we confirm reports that BMD in the MTHFR TT genotype is only significantly reduced in the lowest quartile of riboflavin, B12, B6, and folate intake, at least at the time of menopause.	Folic Acid	149-155	methylenetetrahydrofolate reductase	Homo sapiens	50-55
15756031-2	2005	Methylenetetrahydrofolate reductase (MTHFR) generates the folate derivative for homocysteine remethylation to methionine.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
15635481-1	2005	Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme regulating the metabolism of folate and methionine.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
15514969-2	2005	We conducted a study to examine associations between polymorphisms in folate pathway coenzymes (methylenetetrahydrofolate reductase [MTHFR] and methionine synthase [MS]) and cervical intraepithelial neoplasia (CIN) 2 or 3 in a population exposed to folic acid by the food fortification program in the United States.	Folic Acid	70-76	methylenetetrahydrofolate reductase	Homo sapiens	96-131
15514969-2	2005	We conducted a study to examine associations between polymorphisms in folate pathway coenzymes (methylenetetrahydrofolate reductase [MTHFR] and methionine synthase [MS]) and cervical intraepithelial neoplasia (CIN) 2 or 3 in a population exposed to folic acid by the food fortification program in the United States.	Folic Acid	70-76	methylenetetrahydrofolate reductase	Homo sapiens	133-138
15514969-2	2005	We conducted a study to examine associations between polymorphisms in folate pathway coenzymes (methylenetetrahydrofolate reductase [MTHFR] and methionine synthase [MS]) and cervical intraepithelial neoplasia (CIN) 2 or 3 in a population exposed to folic acid by the food fortification program in the United States.	Folic Acid	70-76	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	144-163
15735067-8	2005	An interaction between the MTHFR genotype and plasma folate on tHcy was detected (P = 0.047).	Folic Acid	53-59	methylenetetrahydrofolate reductase	Homo sapiens	27-32
15735067-11	2005	The results also show that, similar to adults, plasma folate concentration is important in determining the contribution of the MTHFR C677T mutation to tHcy concentrations in children.	Folic Acid	54-60	methylenetetrahydrofolate reductase	Homo sapiens	127-132
16003948-9	2005	Inhibition studies of human rNAT1 and hamster rNAT2 revealed that folic acid and methotrexate (MTX) are competitive inhibitors of both the unacetylated and acetylated forms of the enzymes, with K(I) values in 50 - 300 micro range.	Folic Acid	66-76	N-acetyltransferase 2	Rattus norvegicus	46-51
15652157-1	2005	The human reduced folate carrier (hRFC) is ubiquitously but differentially expressed in human tissues and its levels are regulated by up to six alternatively spliced non-coding regions (designated A1/A2, A, B, C, D, and E) and by at least four promoters.	Folic Acid	18-24	immunoglobulin kappa variable 2D-30	Homo sapiens	197-221
15734217-6	2005	Folate imbalance may result from alterations in folate cellular uptake by the reduced folate carrier (RFC) and/or the folate receptor (FR) and polymorphisms in enzymes important in folate retention such as folylpolyglutamate synthetase and in folate modification such as methylene tetrahydrofolate reductase (MTHFR).	Folic Acid	0-6	methylenetetrahydrofolate reductase	Homo sapiens	271-307
15734217-6	2005	Folate imbalance may result from alterations in folate cellular uptake by the reduced folate carrier (RFC) and/or the folate receptor (FR) and polymorphisms in enzymes important in folate retention such as folylpolyglutamate synthetase and in folate modification such as methylene tetrahydrofolate reductase (MTHFR).	Folic Acid	0-6	methylenetetrahydrofolate reductase	Homo sapiens	309-314
15829163-4	2005	Homozygous MTHFR gene mutation was associated with reduced plasma folate levels, but not with increased plasma HCY levels.	Folic Acid	66-72	methylenetetrahydrofolate reductase	Homo sapiens	11-16
15829163-5	2005	Among the subjects with homozygous MTHFR gene mutation, plasma folate levels in CH was significantly lower than those in CI and controls.	Folic Acid	63-69	methylenetetrahydrofolate reductase	Homo sapiens	35-40
15829163-6	2005	MTHFR gene mutation in CH was found to be as common as that in CI and was associated with reduced plasma folate levels in the both.	Folic Acid	105-111	methylenetetrahydrofolate reductase	Homo sapiens	0-5
15829163-7	2005	In homozygous MTHFR gene mutation, the plasma folate level was profoundly reduced in CH as compared with CI and controls, suggesting that subjects with low plasma folate levels have a predisposition to intracerebral bleeding.	Folic Acid	46-52	methylenetetrahydrofolate reductase	Homo sapiens	14-19
15829163-7	2005	In homozygous MTHFR gene mutation, the plasma folate level was profoundly reduced in CH as compared with CI and controls, suggesting that subjects with low plasma folate levels have a predisposition to intracerebral bleeding.	Folic Acid	163-169	methylenetetrahydrofolate reductase	Homo sapiens	14-19
15588157-2	2005	We explored whether blood folate concentrations in healthy Czech population are associated with polymorphisms in 5,10-methylenetetrahydrofolate reductase (MTHFR), folate hydrolase 1 (FOLH1), reduced folate carrier (RFC), and folate receptor (FOLR1) genes.	Folic Acid	26-32	methylenetetrahydrofolate reductase	Homo sapiens	113-153
15588157-2	2005	We explored whether blood folate concentrations in healthy Czech population are associated with polymorphisms in 5,10-methylenetetrahydrofolate reductase (MTHFR), folate hydrolase 1 (FOLH1), reduced folate carrier (RFC), and folate receptor (FOLR1) genes.	Folic Acid	26-32	methylenetetrahydrofolate reductase	Homo sapiens	155-160
15588157-6	2005	Only the MTHFR 677C&gt;T variant was significantly associated with plasma folate concentrations (median 14.7, 14.0 and 12.2 nmol/l for the CC, CT and TT genotypes, respectively).	Folic Acid	74-80	methylenetetrahydrofolate reductase	Homo sapiens	9-14
15588157-7	2005	Our study showed that among the five studied allelic variants, only the 677C&gt;T polymorphism in the MTHFR gene is a significant genetic determinant of plasma folate concentrations in Czech population.	Folic Acid	160-166	methylenetetrahydrofolate reductase	Homo sapiens	102-107
15598763-1	2004	Methylenetetrahydrofolate reductase (MTHFR) is a key regulatory enzyme in the metabolism of folate, a nutrient which has recently been found to be inversely related to breast cancer in women who drink alcohol.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
15598763-2	2004	Two common variants in the MTHFR gene (C677T and A1298C) have been associated with a reduced activity of this enzyme, thereby increasing the availability of folate for thymidylate and purine synthesis.	Folic Acid	157-163	methylenetetrahydrofolate reductase	Homo sapiens	27-32
15598763-12	2004	This is consistent with the role of MTHFR in facilitating the flow of folate for thymidylate and purine synthesis and with the increased nucleic acid need resulting from the hyperproliferative effect of HRT on mammary epithelial cells.	Folic Acid	70-76	methylenetetrahydrofolate reductase	Homo sapiens	36-41
15582924-2	2004	A thermolabile variant (677C&gt;T) of the enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR) is associated with low serum folate.	Folic Acid	73-79	methylenetetrahydrofolate reductase	Homo sapiens	91-96
15769366-3	2004	We performed a family-based association test and analyzed the interaction between RFC1 A80G genotype and maternal periconceptional supplementation of folic acid.	Folic Acid	150-160	replication factor C subunit 1	Homo sapiens	82-86
15569990-1	2004	PURPOSE: Methylenetetrahydrofolate reductase (MTHFR) directs intracellular folate toward homocysteine metabolism and away from nucleotide synthesis.	Folic Acid	28-34	methylenetetrahydrofolate reductase	Homo sapiens	46-51
15569990-12	2004	CONCLUSIONS: These findings suggest that individuals with the 677CC/1298AA genotype are at higher risk of relapse after hematopoietic cell transplantation and that the balance of intracellular folate metabolites available for nucleotide synthesis (regulated by the relative activity of the MTHFR enzyme) may affect the progression from bcr-abl positivity to clinical relapse.	Folic Acid	193-199	methylenetetrahydrofolate reductase	Homo sapiens	290-295
15546509-1	2004	Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme regulating folate metabolism, which affects DNA synthesis and methylation.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
15609483-4	2004	Among the polymorphic genes and environmental interactions discussed with respect to prenatal development are those for P-glycoprotein (multidrug resistance protein) and the avermectins; methylenetetrahydrofolate reductase (MTHFR), an enzyme in folate metabolism, and dietary folic acid; transforming growth factor alpha (TGFalpha) and cigarette smoke; and alcohol dehydrogenase (ADH) and cytochrome P-450 (CYP) 2E1 in association with alcohol consumption.	Folic Acid	206-212	methylenetetrahydrofolate reductase	Homo sapiens	224-229
15609483-4	2004	Among the polymorphic genes and environmental interactions discussed with respect to prenatal development are those for P-glycoprotein (multidrug resistance protein) and the avermectins; methylenetetrahydrofolate reductase (MTHFR), an enzyme in folate metabolism, and dietary folic acid; transforming growth factor alpha (TGFalpha) and cigarette smoke; and alcohol dehydrogenase (ADH) and cytochrome P-450 (CYP) 2E1 in association with alcohol consumption.	Folic Acid	276-286	methylenetetrahydrofolate reductase	Homo sapiens	187-222
15609483-4	2004	Among the polymorphic genes and environmental interactions discussed with respect to prenatal development are those for P-glycoprotein (multidrug resistance protein) and the avermectins; methylenetetrahydrofolate reductase (MTHFR), an enzyme in folate metabolism, and dietary folic acid; transforming growth factor alpha (TGFalpha) and cigarette smoke; and alcohol dehydrogenase (ADH) and cytochrome P-450 (CYP) 2E1 in association with alcohol consumption.	Folic Acid	276-286	methylenetetrahydrofolate reductase	Homo sapiens	224-229
15492840-2	2004	Genetic polymorphisms that decrease MTHFR activity result in an altered cancer risk depending on folic acid intake.	Folic Acid	97-107	methylenetetrahydrofolate reductase	Homo sapiens	36-41
15688606-5	2004	Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the folate cycle, presenting two common polymorphisms (677C&gt;T and 1298 A&gt;C) which have impact on toxicity and efficacy of methotrexate and 5-fluorouracil.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
15385937-1	2004	Methylenetetrahydrofolate reductase (MTHFR) regulates the metabolism of folate and methionine, essential components of DNA synthesis and methylation.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
15548759-15	2004	Thus, folate deficiency may amplify the effect of other risk factors such as elevated homocysteine levels or variant MTHFR genotype, as well as influencing the ability of antioxidant supplementation to protect against genetic damage.	Folic Acid	6-12	methylenetetrahydrofolate reductase	Homo sapiens	117-122
15561486-0	2004	Methylenetetrahydrofolate reductase polymorphism determines the plasma homocysteine-lowering effect of large-dose folic acid supplementation in patients with cardiovascular disease.	Folic Acid	114-124	methylenetetrahydrofolate reductase	Homo sapiens	0-35
15561486-2	2004	The present study investigated the total homocysteine-lowering effect of folic acid in response to the MTHFR genotype in patients who have cardiovascular disease.	Folic Acid	73-83	methylenetetrahydrofolate reductase	Homo sapiens	103-108
15561486-8	2004	CONCLUSIONS: The MTHFR polymorphism may be involved in the total homocysteine-lowering effect of folic acid in patients who have cardiovascular disease.	Folic Acid	97-107	methylenetetrahydrofolate reductase	Homo sapiens	17-22
15380460-4	2004	Although ethnicity was not a statistically significant modifier, among carriers of the MTHFR 677T/T genotype with serum folate &lt; or =14 nmol/L compared to &gt;14 nmol/L, plasma homocysteine was significantly higher among South Asians (50.9% increase, P &lt; 0.001) and Europeans (52.4% increase, P &lt; 0.001) but not Chinese (11.0% increase, P &gt; 0.05).	Folic Acid	120-126	methylenetetrahydrofolate reductase	Homo sapiens	87-92
15380460-7	2004	CONCLUSION: The combination of lower serum folate and the MTHFR 677T/T genotype is associated with increased plasma homocysteine among South Asians and Europeans, but the association is not evident among Chinese possibly because their serum folate may not have been low enough to compromise MTHFR activity.	Folic Acid	43-49	methylenetetrahydrofolate reductase	Homo sapiens	291-296
15380460-7	2004	CONCLUSION: The combination of lower serum folate and the MTHFR 677T/T genotype is associated with increased plasma homocysteine among South Asians and Europeans, but the association is not evident among Chinese possibly because their serum folate may not have been low enough to compromise MTHFR activity.	Folic Acid	241-247	methylenetetrahydrofolate reductase	Homo sapiens	58-63
15198953-8	2004	The associations of DLCL and FL with TYMS 1494del6 and MTHFR 677TT genotypes, respectively, suggest that folate metabolism may play an important role in the pathogenesis of specific subtypes of NHL.	Folic Acid	105-111	methylenetetrahydrofolate reductase	Homo sapiens	55-60
15378677-5	2004	A recently discovered genetic variant (5,10 MTHFR) leading to altered folic acid metabolism may explain why some individuals are vulnerable to the effects of folic acid deficiency, despite adequate intake.	Folic Acid	70-80	methylenetetrahydrofolate reductase	Homo sapiens	44-49
15378677-5	2004	A recently discovered genetic variant (5,10 MTHFR) leading to altered folic acid metabolism may explain why some individuals are vulnerable to the effects of folic acid deficiency, despite adequate intake.	Folic Acid	158-168	methylenetetrahydrofolate reductase	Homo sapiens	44-49
15449187-2	2004	Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme involved in folate metabolism.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
15322179-8	2004	Folate or nucleoside repletion of folate-deficient cells rapidly restored T lymphocyte proliferation and normal cell cycle, reduced the DNA uracil content, and lowered the CD4(+) to CD8(+) ratio.	Folic Acid	0-6	CD8a molecule	Homo sapiens	182-185
15322179-8	2004	Folate or nucleoside repletion of folate-deficient cells rapidly restored T lymphocyte proliferation and normal cell cycle, reduced the DNA uracil content, and lowered the CD4(+) to CD8(+) ratio.	Folic Acid	34-40	CD8a molecule	Homo sapiens	182-185
15322179-9	2004	These data suggest that folate status may affect the immune system by reducing the capacity of CD8(+) cells to proliferate in response to activation.	Folic Acid	24-30	CD8a molecule	Homo sapiens	95-98
15350988-9	2004	The response to folate repletion suggests that following folate depletion women with the MTHFR 677 TT genotype have a greater increase in DNA methylation with folate repletion than women with the CC genotype.	Folic Acid	16-22	methylenetetrahydrofolate reductase	Homo sapiens	89-94
15350988-9	2004	The response to folate repletion suggests that following folate depletion women with the MTHFR 677 TT genotype have a greater increase in DNA methylation with folate repletion than women with the CC genotype.	Folic Acid	57-63	methylenetetrahydrofolate reductase	Homo sapiens	89-94
15350988-9	2004	The response to folate repletion suggests that following folate depletion women with the MTHFR 677 TT genotype have a greater increase in DNA methylation with folate repletion than women with the CC genotype.	Folic Acid	57-63	methylenetetrahydrofolate reductase	Homo sapiens	89-94
15216546-9	2004	The folate levels demonstrated a statistically significant decrease (P = 0.0477) from the C677T mutation in the MTHFR gene (TT genotype) when compared to the other groups.	Folic Acid	4-10	methylenetetrahydrofolate reductase	Homo sapiens	112-117
15122759-4	2004	Ethanol feeding or folate deficiency, separately or in combination, decreased transcript levels of methylenetetrahydrofolate reductase (MTHFR), methionine adenosyltransferase (MAT1A), glycine-N-methyltransferase (GNMT) and S-adenosylhomocysteine hydrolase (SAHH).	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	99-134
15122759-4	2004	Ethanol feeding or folate deficiency, separately or in combination, decreased transcript levels of methylenetetrahydrofolate reductase (MTHFR), methionine adenosyltransferase (MAT1A), glycine-N-methyltransferase (GNMT) and S-adenosylhomocysteine hydrolase (SAHH).	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	136-141
15066914-5	2004	Compared with the reference group of non-carriers in the lowest quartile of plasma folate, the reduction in risk (66%) was statistically significant among XRCC1 194Trp carriers in the highest quartile (multivariate odds ratio, 0.34; 95% confidence interval, 0.16-0.72).	Folic Acid	83-89	X-ray repair cross complementing 1	Homo sapiens	155-160
15066914-6	2004	The inverse association between XRCC1 194Trp and breast cancer risk was attenuated by lower plasma folate status.	Folic Acid	99-105	X-ray repair cross complementing 1	Homo sapiens	32-37
15059614-11	2004	Erythrocyte folate levels were depressed in the presence of the MTHFR 677C &gt;T variant.	Folic Acid	12-18	methylenetetrahydrofolate reductase	Homo sapiens	64-69
14987511-9	2004	There was an association between age-MTHFR genotype and folic acid, vitamin B12, and red cell folate, but not with homocysteine concentrations.	Folic Acid	56-66	methylenetetrahydrofolate reductase	Homo sapiens	37-42
14987511-9	2004	There was an association between age-MTHFR genotype and folic acid, vitamin B12, and red cell folate, but not with homocysteine concentrations.	Folic Acid	94-100	methylenetetrahydrofolate reductase	Homo sapiens	37-42
15003888-1	2004	BACKGROUND AND OBJECTIVES: Methylenetetrahydrofolate reductase (MTHFR) is one of the enzymes involved in folate metabolism and DNA methylation and synthesis.	Folic Acid	46-52	methylenetetrahydrofolate reductase	Homo sapiens	64-69
14697491-2	2004	Our experiments examined the effects of folic acid supplementation on the endothelial nitric oxide synthase (eNOS) expression in the hyperhomocysteinemic rat brain, and related the observed changes in eNOS expression to the expression of the cell adhesion molecule and the glucose transporter protein.	Folic Acid	40-50	nitric oxide synthase 3	Rattus norvegicus	74-107
14697491-2	2004	Our experiments examined the effects of folic acid supplementation on the endothelial nitric oxide synthase (eNOS) expression in the hyperhomocysteinemic rat brain, and related the observed changes in eNOS expression to the expression of the cell adhesion molecule and the glucose transporter protein.	Folic Acid	40-50	nitric oxide synthase 3	Rattus norvegicus	109-113
14697491-7	2004	Dietary folic acid supplementation caused a significant decrease in the plasma homocysteine levels, a concomitant increase in the hyperhomocysteinemia-induced reduction in the cerebral eNOS and GLUT-1 expression levels, and a decrease in the hyperhomocysteinemia-induced VCAM-1 expression levels.	Folic Acid	8-18	nitric oxide synthase 3	Rattus norvegicus	185-189
14734703-2	2004	The C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with changes in cellular composition of folates.	Folic Acid	133-140	methylenetetrahydrofolate reductase	Homo sapiens	30-65
14734703-2	2004	The C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with changes in cellular composition of folates.	Folic Acid	133-140	methylenetetrahydrofolate reductase	Homo sapiens	67-72
14734703-8	2004	RESULTS: Compared with cells expressing the wild-type MTHFR, HCT116 and MDA-MB-435 cells expressing the mutant 677T MTHFR had decreased MTHFR activity, MTHFR thermolability, changed intracellular folate distribution, accelerated cellular growth rate, and increased thymidylate synthase activity.	Folic Acid	196-202	methylenetetrahydrofolate reductase	Homo sapiens	116-121
14734703-8	2004	RESULTS: Compared with cells expressing the wild-type MTHFR, HCT116 and MDA-MB-435 cells expressing the mutant 677T MTHFR had decreased MTHFR activity, MTHFR thermolability, changed intracellular folate distribution, accelerated cellular growth rate, and increased thymidylate synthase activity.	Folic Acid	196-202	methylenetetrahydrofolate reductase	Homo sapiens	116-121
14734703-8	2004	RESULTS: Compared with cells expressing the wild-type MTHFR, HCT116 and MDA-MB-435 cells expressing the mutant 677T MTHFR had decreased MTHFR activity, MTHFR thermolability, changed intracellular folate distribution, accelerated cellular growth rate, and increased thymidylate synthase activity.	Folic Acid	196-202	methylenetetrahydrofolate reductase	Homo sapiens	116-121
14734703-11	2004	CONCLUSIONS: Our data provide evidence that the MTHFR C677T polymorphism affects the concentration and intracellular distribution of folates and changes the growth and chemosensitivity of colon and breast cancer cells.	Folic Acid	133-140	methylenetetrahydrofolate reductase	Homo sapiens	48-53
14717963-7	2004	For all MTHFR genotypes combined, the OR for MI in the lowest quartile of folate (&lt;5.4 nmol L-1) compared with the highest quartile (&gt;10.4 nmol L-1) was 3.0 (95% CI 1.7, 5.1).	Folic Acid	74-80	methylenetetrahydrofolate reductase	Homo sapiens	8-13
15583437-2	2004	In this respect, methylenetetrahydrofolate reductase (MTHFR) plays a central role in folate metabolism that affects DNA methylation and synthesis.	Folic Acid	36-42	methylenetetrahydrofolate reductase	Homo sapiens	54-59
14639706-7	2003	We also looked for possible gene-gene interaction with the polymorphic variant C677T of the folic acid-metabolizing gene MTHFR.	Folic Acid	92-102	methylenetetrahydrofolate reductase	Homo sapiens	121-126
14714317-10	2003	An interaction between serum folate level and MTHFR genotype that affect the Hcy level is an important risk factor for DVT.	Folic Acid	29-35	methylenetetrahydrofolate reductase	Homo sapiens	46-51
14607573-0	2003	C677T methylenetetrahydrofolate reductase polymorphism interferes with the effects of folic acid and zinc sulfate on sperm concentration.	Folic Acid	86-96	methylenetetrahydrofolate reductase	Homo sapiens	6-41
14607573-1	2003	OBJECTIVE: To determine the frequency of C677T methylenetetrahydrofolate reductase (MTHFR) polymorphism in fertile and subfertile males, and the MTHFR-dependent response of sperm concentration after folic acid and/or zinc sulfate intervention.	Folic Acid	199-209	methylenetetrahydrofolate reductase	Homo sapiens	145-150
14607573-11	2003	In contrast to heterozygotes and homozygotes for C677T MTHFR polymorphism, sperm concentration in wild-types significantly improved after folic acid and zinc sulfate intervention.	Folic Acid	138-148	methylenetetrahydrofolate reductase	Homo sapiens	55-60
14608052-1	2003	The C677T variant of methylenetetrahydrofolate reductase (MTHFR), a key enzyme in the remethylation of homocysteine to methionine, is a frequent genetic cause of mild hyperhomocysteinemia among individuals with low folate status.	Folic Acid	40-46	methylenetetrahydrofolate reductase	Homo sapiens	58-63
12949355-0	2003	Combined marginal folate and riboflavin status affect homocysteine methylation in cultured immortalized lymphocytes from persons homozygous for the MTHFR C677T mutation.	Folic Acid	18-24	methylenetetrahydrofolate reductase	Homo sapiens	148-153
12939425-4	2003	In CSF, the overall folate binding capacity by the two soluble folate-binding proteins FBP1 and FBP2 (sFBP) was measured using a radioligand binding method for H3-labeled folate.	Folic Acid	20-26	fructose-bisphosphatase 1	Homo sapiens	87-91
12939425-4	2003	In CSF, the overall folate binding capacity by the two soluble folate-binding proteins FBP1 and FBP2 (sFBP) was measured using a radioligand binding method for H3-labeled folate.	Folic Acid	63-69	fructose-bisphosphatase 1	Homo sapiens	87-91
12939425-4	2003	In CSF, the overall folate binding capacity by the two soluble folate-binding proteins FBP1 and FBP2 (sFBP) was measured using a radioligand binding method for H3-labeled folate.	Folic Acid	63-69	fructose-bisphosphatase 1	Homo sapiens	87-91
12939425-15	2003	The lowered folate binding capacity of FBP is not explained by a defect of the FBP1 or FBP2 gene, but most likely occurs as a secondary phenomenon in Rett syndrome.	Folic Acid	12-18	fructose-bisphosphatase 1	Homo sapiens	39-42
12814391-3	2003	Our results showed the following: (i) Compared with healthy control subjects (n = 9), patients with hyperhomocysteinaemia (n = 9) had elevated mRNA levels of MMP-9 and tissue inhibitors of metalloproteinases-1 (TIMP-1) in freshly isolated peripheral blood mononuclear cells (PBMCs), which were positively correlated with homocysteine and negatively correlated with folate and vitamin B12 levels.	Folic Acid	365-371	matrix metallopeptidase 9	Homo sapiens	158-163
12814391-5	2003	(iii) During folic acid 6 weeks" treatment, normalization of homocysteine levels was accompanied by a significant reduction in mRNA levels of MMP-9 and TIMP-1 in PBMCs, as well as a marked reduction in oxLDL-stimulated release of MMP enzyme activity.	Folic Acid	13-23	matrix metallopeptidase 9	Homo sapiens	142-147
12814391-5	2003	(iii) During folic acid 6 weeks" treatment, normalization of homocysteine levels was accompanied by a significant reduction in mRNA levels of MMP-9 and TIMP-1 in PBMCs, as well as a marked reduction in oxLDL-stimulated release of MMP enzyme activity.	Folic Acid	13-23	matrix metallopeptidase 9	Homo sapiens	142-145
12855225-2	2003	The first such sequence change was the 677C--&gt;T substitution in methylenetetrahydrofolate reductase (MTHFR), but additional sequence changes have been identified in enzymes or transporters for folates.	Folic Acid	196-203	methylenetetrahydrofolate reductase	Homo sapiens	67-102
12855225-2	2003	The first such sequence change was the 677C--&gt;T substitution in methylenetetrahydrofolate reductase (MTHFR), but additional sequence changes have been identified in enzymes or transporters for folates.	Folic Acid	196-203	methylenetetrahydrofolate reductase	Homo sapiens	104-109
12855225-3	2003	Two recently identified variants are the 1561C--&gt;T (H475Y) mutation in glutamate carboxypeptidase II (GCPII) and the 80A--&gt;G (H27R) change in the reduced folate carrier RFC-1.	Folic Acid	160-166	replication factor C subunit 1	Homo sapiens	175-180
12855226-17	2003	The biological implications of the limited number of MTHFR/MTHFR mutant alleles that can coexist, usually no more than two, may be explained by the serious consequences to folate status that these genotype combinations precipitate.	Folic Acid	172-178	methylenetetrahydrofolate reductase	Homo sapiens	53-58
12855226-17	2003	The biological implications of the limited number of MTHFR/MTHFR mutant alleles that can coexist, usually no more than two, may be explained by the serious consequences to folate status that these genotype combinations precipitate.	Folic Acid	172-178	methylenetetrahydrofolate reductase	Homo sapiens	59-64
12831960-1	2003	OBJECTIVES: The possible link between folic acid or folate and tetrahydrobiopterin (H(4)B), vitamin C, polyunsaturated fatty acids (PUFAs), and nitric oxide (NO), which may explain the beneficial actions of these nutrients in various vascular conditions, was investigated.	Folic Acid	38-48	H4 clustered histone 4	Homo sapiens	63-89
12831960-1	2003	OBJECTIVES: The possible link between folic acid or folate and tetrahydrobiopterin (H(4)B), vitamin C, polyunsaturated fatty acids (PUFAs), and nitric oxide (NO), which may explain the beneficial actions of these nutrients in various vascular conditions, was investigated.	Folic Acid	52-58	H4 clustered histone 4	Homo sapiens	63-89
12670934-1	2003	Vitamins B12, B6, and folic acid converge at the homocysteine metabolic junction where they support the activities of two key enzymes involved in intracellular homocysteine management, methionine synthase (MS) and cystathionine beta-synthase.	Folic Acid	22-32	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	185-204
12670934-1	2003	Vitamins B12, B6, and folic acid converge at the homocysteine metabolic junction where they support the activities of two key enzymes involved in intracellular homocysteine management, methionine synthase (MS) and cystathionine beta-synthase.	Folic Acid	22-32	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	206-208
12730409-0	2003	Methylenetetrahydrofolate reductase 677C--&gt;T variant modulates folate status response to controlled folate intakes in young women.	Folic Acid	66-72	methylenetetrahydrofolate reductase	Homo sapiens	0-35
12966656-4	2003	Moreover there is a genetic factor with higher incidence of a TT homozygotic mutation of the MTHFR that increases homocysteine because of an altered folate metabolism.	Folic Acid	149-155	methylenetetrahydrofolate reductase	Homo sapiens	93-98
12642343-3	2003	Serum folate, red cell folate, vitamin B(12), and tHcy concentrations were significantly influenced by MTHFR 677C&gt;T genotypes.	Folic Acid	6-12	methylenetetrahydrofolate reductase	Homo sapiens	103-108
12642343-3	2003	Serum folate, red cell folate, vitamin B(12), and tHcy concentrations were significantly influenced by MTHFR 677C&gt;T genotypes.	Folic Acid	23-29	methylenetetrahydrofolate reductase	Homo sapiens	103-108
12642343-4	2003	A particularly strong interaction was observed between the MTHFR 677TT genotype and serum folate, which led to a high tHcy phenotype that was more pronounced in males.	Folic Acid	90-96	methylenetetrahydrofolate reductase	Homo sapiens	59-64
12519783-1	2003	The human reduced folate carrier (hRFC) is the dominant transporter mediating the uptake of reduced folate cofactors and antifolate anticancer drugs.	Folic Acid	18-24	replication factor C subunit 1	Homo sapiens	34-38
12519783-1	2003	The human reduced folate carrier (hRFC) is the dominant transporter mediating the uptake of reduced folate cofactors and antifolate anticancer drugs.	Folic Acid	100-106	replication factor C subunit 1	Homo sapiens	34-38
12618331-1	2003	Methylenetetrahydrofolate reductase (MTHFR) is an essential enzyme in the folate metabolism, which affects DNA synthesis and methylation.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
12600862-0	2003	Effect of the methylenetetrahydrofolate reductase 677C--&gt;T mutation on the relations among folate intake and plasma folate and homocysteine concentrations in a general population sample.	Folic Acid	94-100	methylenetetrahydrofolate reductase	Homo sapiens	14-49
12600862-1	2003	BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate and homocysteine metabolism.	Folic Acid	31-37	methylenetetrahydrofolate reductase	Homo sapiens	49-54
12797455-1	2003	BACKGROUND: Several studies have suggested that homozygosity for the C677T 5,10-methylenetetrahydrofolate reductase (MTHFR) variant is a potential risk factor for neural tube defects (NTDs), as individuals homozygous for the C677T allele have slightly elevated homocysteine concentrations under conditions of low folic acid intake.	Folic Acid	313-323	methylenetetrahydrofolate reductase	Homo sapiens	80-115
12797455-1	2003	BACKGROUND: Several studies have suggested that homozygosity for the C677T 5,10-methylenetetrahydrofolate reductase (MTHFR) variant is a potential risk factor for neural tube defects (NTDs), as individuals homozygous for the C677T allele have slightly elevated homocysteine concentrations under conditions of low folic acid intake.	Folic Acid	313-323	methylenetetrahydrofolate reductase	Homo sapiens	117-122
12797455-2	2003	It has been hypothesized that maternal folic acid supplementation prevents NTDs by partially correcting reduced MTHFR activity associated with the variant form of the enzyme.	Folic Acid	39-49	methylenetetrahydrofolate reductase	Homo sapiens	112-117
12694231-2	2003	Methylenetetrahydrofolate reductase (MTHFR) is a candidate gene in the folate metabolism pathway that has been extensively studied in different human populations.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42
12560354-3	2003	Individuals with the MTHFR 677C--&gt;T mutation have increased plasma total homocysteine (tHcy) concentrations, particularly in association with low folate status.	Folic Acid	149-155	methylenetetrahydrofolate reductase	Homo sapiens	21-26
12560354-10	2003	CONCLUSIONS: Folate and riboflavin interact to lower plasma tHcy, possibly by maximizing the catalytic activity of MTHFR.	Folic Acid	13-19	methylenetetrahydrofolate reductase	Homo sapiens	115-120
12553950-5	2003	Folate status assessment was determined by plasma tHcy, serum and erythrocyte folate and C677T for MTHFR in 342 healthy women.	Folic Acid	0-6	methylenetetrahydrofolate reductase	Homo sapiens	99-104
12626825-4	2003	Based on evidence that abnormal folate and methyl metabolism can lead to DNA hypomethylation and abnormal chromosomal segregation, researchers have observed that mothers with mutation in MTHFR (C677T) and MTRR (A66G) gene have elevated levels of plasma homocysteine.	Folic Acid	32-38	methylenetetrahydrofolate reductase	Homo sapiens	187-192
12589326-1	2003	OBJECTIVE: To determine the prevalence of methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms in women of different ethnic groups and to relate these common mutations to plasma homocysteine, red cell folate, and serum folate.	Folic Acid	61-67	methylenetetrahydrofolate reductase	Homo sapiens	79-84
12471611-1	2003	MTHFR is a critical enzyme that regulates the metabolism of folate and methionine, both of which are important factors in DNA methylation and synthesis.	Folic Acid	60-66	methylenetetrahydrofolate reductase	Homo sapiens	0-5
14564626-11	2003	During human GI carcinogenesis, MTHFR is highly polymorphic, and the variant genotypes result in decreased MTHFR enzyme activity and lower plasma folate level, as well as aberrant methylation.	Folic Acid	146-152	methylenetetrahydrofolate reductase	Homo sapiens	32-37
12204804-6	2002	These findings suggest that elevated homocysteine levels among Japanese with the homozygous genotype for the MTHFR gene mutation can be modified efficiently by dietary supplement of vitamin B12 as well as folate.	Folic Acid	205-211	methylenetetrahydrofolate reductase	Homo sapiens	109-114
12237638-7	2002	For each genotype of methylenetetrahydrofolate reductase, lower levels of serum folate were observed in pregnant women who smoked, with the lowest folate levels seen in homozygous mutant methylenetetrahydrofolate reductase 677TT (18.6 nmol/L in pregnant women who smoked vs 24.2 nmol/L in pregnant women who did not smoke).	Folic Acid	40-46	methylenetetrahydrofolate reductase	Homo sapiens	187-222
12237638-7	2002	For each genotype of methylenetetrahydrofolate reductase, lower levels of serum folate were observed in pregnant women who smoked, with the lowest folate levels seen in homozygous mutant methylenetetrahydrofolate reductase 677TT (18.6 nmol/L in pregnant women who smoked vs 24.2 nmol/L in pregnant women who did not smoke).	Folic Acid	80-86	methylenetetrahydrofolate reductase	Homo sapiens	21-56
12237638-7	2002	For each genotype of methylenetetrahydrofolate reductase, lower levels of serum folate were observed in pregnant women who smoked, with the lowest folate levels seen in homozygous mutant methylenetetrahydrofolate reductase 677TT (18.6 nmol/L in pregnant women who smoked vs 24.2 nmol/L in pregnant women who did not smoke).	Folic Acid	80-86	methylenetetrahydrofolate reductase	Homo sapiens	187-222
12416030-0	2002	Severe folate restriction results in depletion of and alteration in the composition of the intracellular folate pool, moderate sensitization to methotrexate and trimetrexate, upregulation of endogenous DHFR activity, and overexpression of metallothionein II and folate receptor alpha that, upon folate repletion, confer drug resistance to CHL cells.	Folic Acid	7-13	folate receptor alpha	Cricetulus griseus	262-283
12163697-6	2002	Recently, an interaction was observed between folate status and a common mutation in the gene encoding for methylenetetrahydrofolate reductase, an essential enzyme in one-carbon metabolism, in determining genomic DNA methylation.	Folic Acid	46-52	methylenetetrahydrofolate reductase	Homo sapiens	107-142
12163703-6	2002	The hypothesis that these two pathways are the means by which folate modulates cancer risk is also supported by the epidemiological observation that a common polymorphism in the methylenetetrahydrofolate reductase (MTHFR; EC 1.5.1.20) gene differentially affects the relative risk of colon cancer depending on folate status, because MTHFR catalyzes the reaction that determines whether cellular folate is diverted into biological methylation or nucleotide synthesis.	Folic Acid	62-68	methylenetetrahydrofolate reductase	Homo sapiens	178-213
12163703-6	2002	The hypothesis that these two pathways are the means by which folate modulates cancer risk is also supported by the epidemiological observation that a common polymorphism in the methylenetetrahydrofolate reductase (MTHFR; EC 1.5.1.20) gene differentially affects the relative risk of colon cancer depending on folate status, because MTHFR catalyzes the reaction that determines whether cellular folate is diverted into biological methylation or nucleotide synthesis.	Folic Acid	62-68	methylenetetrahydrofolate reductase	Homo sapiens	215-220
12163703-6	2002	The hypothesis that these two pathways are the means by which folate modulates cancer risk is also supported by the epidemiological observation that a common polymorphism in the methylenetetrahydrofolate reductase (MTHFR; EC 1.5.1.20) gene differentially affects the relative risk of colon cancer depending on folate status, because MTHFR catalyzes the reaction that determines whether cellular folate is diverted into biological methylation or nucleotide synthesis.	Folic Acid	62-68	methylenetetrahydrofolate reductase	Homo sapiens	333-338
12163703-6	2002	The hypothesis that these two pathways are the means by which folate modulates cancer risk is also supported by the epidemiological observation that a common polymorphism in the methylenetetrahydrofolate reductase (MTHFR; EC 1.5.1.20) gene differentially affects the relative risk of colon cancer depending on folate status, because MTHFR catalyzes the reaction that determines whether cellular folate is diverted into biological methylation or nucleotide synthesis.	Folic Acid	197-203	methylenetetrahydrofolate reductase	Homo sapiens	215-220
12163703-6	2002	The hypothesis that these two pathways are the means by which folate modulates cancer risk is also supported by the epidemiological observation that a common polymorphism in the methylenetetrahydrofolate reductase (MTHFR; EC 1.5.1.20) gene differentially affects the relative risk of colon cancer depending on folate status, because MTHFR catalyzes the reaction that determines whether cellular folate is diverted into biological methylation or nucleotide synthesis.	Folic Acid	197-203	methylenetetrahydrofolate reductase	Homo sapiens	333-338
12163703-6	2002	The hypothesis that these two pathways are the means by which folate modulates cancer risk is also supported by the epidemiological observation that a common polymorphism in the methylenetetrahydrofolate reductase (MTHFR; EC 1.5.1.20) gene differentially affects the relative risk of colon cancer depending on folate status, because MTHFR catalyzes the reaction that determines whether cellular folate is diverted into biological methylation or nucleotide synthesis.	Folic Acid	197-203	methylenetetrahydrofolate reductase	Homo sapiens	215-220
12163703-6	2002	The hypothesis that these two pathways are the means by which folate modulates cancer risk is also supported by the epidemiological observation that a common polymorphism in the methylenetetrahydrofolate reductase (MTHFR; EC 1.5.1.20) gene differentially affects the relative risk of colon cancer depending on folate status, because MTHFR catalyzes the reaction that determines whether cellular folate is diverted into biological methylation or nucleotide synthesis.	Folic Acid	197-203	methylenetetrahydrofolate reductase	Homo sapiens	333-338
12097662-5	2002	The C677T and A1298C MTHFR polymorphisms were significant predictors (P &lt; 0.05) of plasma homocysteine when regression analysis was used to model plasma homocysteine concentration as a function of genotype, supplement use, serum folate and plasma vitamin B-12 concentration.	Folic Acid	232-238	methylenetetrahydrofolate reductase	Homo sapiens	21-26
11997266-1	2002	Although the reduced folate carrier RFC1 and the thiamine transporters THTR-1 and THTR-2 share approximately 40% of their identity in protein sequence, RFC1 does not transport thiamine and THTR-1 and THTR-2 do not transport folates.	Folic Acid	21-27	solute carrier family 19, member 3	Mus musculus	82-88
12036927-0	2002	Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system.	Folic Acid	29-35	ATP binding cassette subfamily C member 4	Homo sapiens	81-86
12036927-0	2002	Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system.	Folic Acid	29-35	ATP binding cassette subfamily C member 4	Homo sapiens	89-93
12036927-4	2002	In so doing, it is shown that MRP4 is active in the transport of MTX as well as the physiological folates folic acid (FA) and N(5)-formyltetrahydrofolic acid (leucovorin).	Folic Acid	98-105	ATP binding cassette subfamily C member 4	Homo sapiens	30-34
12042673-1	2002	A common polymorphism in a folate-metabolizing gene, methylenetetrahydrofolate reductase (MTHFR) 677C&gt;T has been associated with reduced risk of colorectal cancer.	Folic Acid	27-33	methylenetetrahydrofolate reductase	Homo sapiens	53-88
12042673-1	2002	A common polymorphism in a folate-metabolizing gene, methylenetetrahydrofolate reductase (MTHFR) 677C&gt;T has been associated with reduced risk of colorectal cancer.	Folic Acid	27-33	methylenetetrahydrofolate reductase	Homo sapiens	90-95
12042673-2	2002	In this study, we investigated whether a second common polymorphism of the gene, MTHFR 1298A&gt;C, is an independent risk factor for colorectal cancer and if it is associated with plasma folate and total homocysteine (tHcy) levels.	Folic Acid	187-193	methylenetetrahydrofolate reductase	Homo sapiens	81-86
11941454-6	2002	Supplemental administration of low levels of ADCC-activating cytokines [e.g. interleukin-2 (IL-2) and interferon-alpha (IFN-alpha)] has been shown to synergize with the folate-targeted immunotherapy.	Folic Acid	169-175	interferon alpha	Mus musculus	102-118
11941454-6	2002	Supplemental administration of low levels of ADCC-activating cytokines [e.g. interleukin-2 (IL-2) and interferon-alpha (IFN-alpha)] has been shown to synergize with the folate-targeted immunotherapy.	Folic Acid	169-175	interferon alpha	Mus musculus	120-129
11941454-7	2002	Thus, using M109 syngeneic lung cancer cells injected intraperitoneally into Balb/c mice that were previously immunized against fluorescein, a significant extension of life span is observed following treatment with folate-fluorescein conjugates, and complete cures are observed upon supplementation with moderate levels of IL-2 and IFN-alpha.	Folic Acid	215-221	interferon alpha	Mus musculus	332-341
12021520-2	2002	methylcobalamin (Me-Cbl), the coenzymatically active form of vitamin B12 that acts as a cofactor for methionine synthase in the conversion of total homocysteine (tHcy) to methionine, with or without oral folic acid (FA) supplementation, on fasting tHcy levels in hemodialysis (HD) patients.	Folic Acid	204-214	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	101-120
12020105-6	2002	CONCLUSIONS: This study provides additional evidence for a decreased CRC risk for subjects with the MTHFR 677T allele, particularly at high levels of folate and vitamin B6 intake.	Folic Acid	150-156	methylenetetrahydrofolate reductase	Homo sapiens	100-105
11956665-9	2002	The sufficiently high dose of folate seems to be able to decrease plasma tHcy in all three individual MTHFR polymorphism groups, to almost the same post-treatment concentrations.	Folic Acid	30-36	methylenetetrahydrofolate reductase	Homo sapiens	102-107
11781870-2	2002	When folic acid intake is sufficient, homozygotes for MTHFR 677T appear to be protected against colon cancer and acute lymphatic leukemia, and fetuses bearing this genotype have an augmented survival.	Folic Acid	5-15	methylenetetrahydrofolate reductase	Homo sapiens	54-59
11872199-10	2002	CONCLUSION(S): The MTHFR polymorphism was associated with a higher Hcy concentration, and this association was related to the serum folate level.	Folic Acid	132-138	methylenetetrahydrofolate reductase	Homo sapiens	19-24
11865092-16	2002	(ii) After folate therapy, tHcy levels decreased significantly in all patients and were identical between the three C677T MTHFR genotype subgroups.	Folic Acid	11-17	methylenetetrahydrofolate reductase	Homo sapiens	122-127
12013675-1	2002	Homozygosity for a common polymorphism in the 5,10 methylenetetrahydrofolate reductase (MTHFR) gene (C677T) has been associated to an increased risk of neural tube defects as well as derangements in folate, homocysteine, and hematological parameters.	Folic Acid	70-76	methylenetetrahydrofolate reductase	Homo sapiens	88-93
11839091-14	2002	Allopurinol and folic acid inhibited the activities of XDH and XO, decreased their ratio (XDH/XO), and lowered the levels of peroxidative damage and the specific activity of LDH.	Folic Acid	16-26	xanthine dehydrogenase	Mus musculus	55-58
11839091-14	2002	Allopurinol and folic acid inhibited the activities of XDH and XO, decreased their ratio (XDH/XO), and lowered the levels of peroxidative damage and the specific activity of LDH.	Folic Acid	16-26	xanthine dehydrogenase	Mus musculus	63-65
11839091-14	2002	Allopurinol and folic acid inhibited the activities of XDH and XO, decreased their ratio (XDH/XO), and lowered the levels of peroxidative damage and the specific activity of LDH.	Folic Acid	16-26	xanthine dehydrogenase	Mus musculus	90-93
11839091-14	2002	Allopurinol and folic acid inhibited the activities of XDH and XO, decreased their ratio (XDH/XO), and lowered the levels of peroxidative damage and the specific activity of LDH.	Folic Acid	16-26	xanthine dehydrogenase	Mus musculus	94-96
11839091-15	2002	These results suggested that allopurinol and folic acid have the ability to inhibit the radiation-induced changes in the activities of XDH and XO and to attenuate the detrimental effect of this conversion, as is evident from the diminished levels of peroxidative damage and the decreased activity of LDH.	Folic Acid	45-55	xanthine dehydrogenase	Mus musculus	135-138
11839091-15	2002	These results suggested that allopurinol and folic acid have the ability to inhibit the radiation-induced changes in the activities of XDH and XO and to attenuate the detrimental effect of this conversion, as is evident from the diminished levels of peroxidative damage and the decreased activity of LDH.	Folic Acid	45-55	xanthine dehydrogenase	Mus musculus	143-145
11938441-6	2002	The present finding of high prevalence of mutated MTHFR genotypes in spontaneously aborted embryos emphasises the potential protective role of periconceptional folic acid supplementation.	Folic Acid	160-170	methylenetetrahydrofolate reductase	Homo sapiens	50-55
12545203-4	2002	Catecholamine depletion evoked by reserpine drastically decreases the folate-induced activity of S-adenosylmethionine decarboxylase (AdoMetDC), which limits polyamine biosynthesis, but has no effect on SSAT activity augmented by CB 3717.	Folic Acid	70-76	S-adenosylmethionine decarboxylase 1	Mus musculus	97-131
12545203-4	2002	Catecholamine depletion evoked by reserpine drastically decreases the folate-induced activity of S-adenosylmethionine decarboxylase (AdoMetDC), which limits polyamine biosynthesis, but has no effect on SSAT activity augmented by CB 3717.	Folic Acid	70-76	S-adenosylmethionine decarboxylase 1	Mus musculus	133-141
12050947-6	2002	Stepwise multiple linear regression with MCV as dependent and GGT, B12, folate and tHcy as independent variables, respectively, revealed significant associations of MCV with GGT (B = 2.18, 95% CI 0.95-3.42, P = 0.001) and tHcy (B = 3.33, 95% CI 1.26-5.39, P = 0.002).	Folic Acid	72-78	gamma-glutamyltransferase 1	Homo sapiens	174-177
23105344-3	2002	A common mutation (C677T) in the gene encoding for the enzyme 5, 10-methylenetetrahydrofolate reductase (MTHFR) or deficiency of the B vitamins namely folic acid, B(12), B(6) can lead to hyperhomocysteinemia.In the present study, we have investigated the incidence of the (C677T) MTHFR polymorphism in the North Indian males.	Folic Acid	151-161	methylenetetrahydrofolate reductase	Homo sapiens	105-110
23105344-3	2002	A common mutation (C677T) in the gene encoding for the enzyme 5, 10-methylenetetrahydrofolate reductase (MTHFR) or deficiency of the B vitamins namely folic acid, B(12), B(6) can lead to hyperhomocysteinemia.In the present study, we have investigated the incidence of the (C677T) MTHFR polymorphism in the North Indian males.	Folic Acid	151-161	methylenetetrahydrofolate reductase	Homo sapiens	280-285
11556805-12	2001	These results indicate that mice are able to oxidize formate to CO(2) by at least three different routes: (1) folate-dependent via FDH at low levels of formate; (2) peroxidation by catalase at high levels of formate; and (3) by an unknown route(s) which appears to function at both low and high levels of formate.	Folic Acid	110-116	aldehyde dehydrogenase 1 family, member L1	Mus musculus	131-134
11532093-9	2001	RESULTS: Using RT-PCR, PTHrP mRNA was rapidly (1 hour) and maximally increased (3-fold) in the rat kidney after folic acid, decreasing after six hours.	Folic Acid	112-122	parathyroid hormone-like hormone	Rattus norvegicus	23-28
11532093-11	2001	In contrast, the PTH/PTHrP receptor mRNA (RNase protection assay) decreased shortly after folic acid administration.	Folic Acid	90-100	parathyroid hormone-like hormone	Rattus norvegicus	21-26
11532093-12	2001	Moreover, PTH/PTHrP receptor immunostaining dramatically decreased in renal tubular cell membranes after folic acid.	Folic Acid	105-115	parathyroid hormone-like hormone	Rattus norvegicus	14-19
11532093-13	2001	A single subcutaneous administration of PTHrP (1-36), 3 or 50 microg/kg body weight, shortly after folic acid injection increased the number of tubular cells staining for proliferating cell nuclear antigen by 30% (P &lt; 0.05) or 50% (P &lt; 0.01), respectively, in these rats at 24 hours, without significant changes in either renal function or calcemia.	Folic Acid	99-109	parathyroid hormone-like hormone	Rattus norvegicus	40-45
11532093-15	2001	The addition of 10 mmol/L folic acid to NRK 52E cells caused a twofold increase in PTHrP mRNA at six hours, without significant changes in the PTH/PTHrP receptor mRNA.	Folic Acid	26-36	parathyroid hormone-like hormone	Rattus norvegicus	83-88
11532093-17	2001	CONCLUSIONS: Renal PTHrP was rapidly and transiently increased in rats with folic acid-induced acute renal failure, featuring as an early response gene.	Folic Acid	76-86	parathyroid hormone-like hormone	Rattus norvegicus	19-24
11532093-19	2001	PTHrP induces a mitogenic response in folic acid-damaged renal tubular cells both in vivo and in vitro.	Folic Acid	38-48	parathyroid hormone-like hormone	Rattus norvegicus	0-5
11488596-12	2001	The loss of urocanase activity in homozygous NEUT2 mice may allow these mice to survive the disruption in folate metabolism by sparing the liver cytosolic tetrahydrofolate pool.	Folic Acid	106-112	aldehyde dehydrogenase 1 family, member L1	Mus musculus	45-50
11443546-2	2001	Thus, recent reports linking Down syndrome to maternal polymorphisms at either of two folate metabolism enzymes, methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR), have generated considerable interest.	Folic Acid	86-92	methylenetetrahydrofolate reductase	Homo sapiens	113-148
11443546-2	2001	Thus, recent reports linking Down syndrome to maternal polymorphisms at either of two folate metabolism enzymes, methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR), have generated considerable interest.	Folic Acid	86-92	methylenetetrahydrofolate reductase	Homo sapiens	150-155
11534765-0	2001	In vivo antitumor efficacy of CW252053, a folate-based thymidylate synthase inhibitor.	Folic Acid	42-48	thymidylate synthase	Mus musculus	55-75
11519232-11	2001	As for the genetic polymorphism of the V677 gen of the metylenetetrahydrofolate-reductase (MTHFR) enzyme there was a significant correlation with homocysteine level (r = 0.436, p = 0.010), and a negative, but not significant correlation with the folic acid level (r = -0.354).	Folic Acid	246-256	methylenetetrahydrofolate reductase	Homo sapiens	55-89
11519232-11	2001	As for the genetic polymorphism of the V677 gen of the metylenetetrahydrofolate-reductase (MTHFR) enzyme there was a significant correlation with homocysteine level (r = 0.436, p = 0.010), and a negative, but not significant correlation with the folic acid level (r = -0.354).	Folic Acid	246-256	methylenetetrahydrofolate reductase	Homo sapiens	91-96
11431185-4	2001	Multiple stepwise regression analysis showed that the MTHFR 677C--&gt;T/1298A--&gt;C genotype (CC/AA, CC/AC, CC/CC, CT/AA, CT/AC, TT/AA), vitamin use, age, folate and vitamin B(12) plasma level were significant predictors of tHcy plasma levels.	Folic Acid	156-162	methylenetetrahydrofolate reductase	Homo sapiens	54-59
11424140-9	2001	In conclusion, in smokers, high folate status may confer increased or decreased risk for HRAs, depending on the MTHFR genotype.	Folic Acid	32-38	methylenetetrahydrofolate reductase	Homo sapiens	112-117
11520404-5	2001	The second hypothesised pathway is a gene-environment interaction based on a highly prevalent mutation in the gene for methylenetetrahydrofolate reductase (MTHFR), combined with low folate intake from the diet and from prenatal vitamin supplements, consequent hyperhomocysteinemia, and decidual vasculopathy.	Folic Acid	138-144	methylenetetrahydrofolate reductase	Homo sapiens	156-161
11433922-1	2001	MTHFR encodes a critical enzyme in folate and homocysteine metabolism and the C677T allele of the MTHFR gene has some association with an increased risk for neural-tube defects and for adult cardiovascular diseases.	Folic Acid	35-41	methylenetetrahydrofolate reductase	Homo sapiens	0-5
11433922-1	2001	MTHFR encodes a critical enzyme in folate and homocysteine metabolism and the C677T allele of the MTHFR gene has some association with an increased risk for neural-tube defects and for adult cardiovascular diseases.	Folic Acid	35-41	methylenetetrahydrofolate reductase	Homo sapiens	98-103
11398138-8	2001	The C677T polymorphism of the methylenetetrahydrofolate reductase (MTHFR), a key enzyme of folate and homocysteine metabolism, was determined by polymerase chain reaction (PCR) with restriction enzyme analysis.	Folic Acid	49-55	methylenetetrahydrofolate reductase	Homo sapiens	67-72
11325838-0	2001	Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors.	Folic Acid	30-37	thymidylate synthase	Mus musculus	88-108
11177206-2	2000	The aim of the present study was to determine the impact of this MTHFR common mutation on plasma and erythrocyte folate (RCF) and plasma total homocysteine (tHcy) concentrations in healthy French adults.	Folic Acid	113-119	methylenetetrahydrofolate reductase	Homo sapiens	65-70
11136550-0	2000	Identification and characterization of the human and mouse SLC19A3 gene: a novel member of the reduced folate family of micronutrient transporter genes.	Folic Acid	103-109	solute carrier family 19, member 3	Mus musculus	59-66
11074217-2	2000	We therefore investigated the association between recurrent cardiovascular events and a mutation in methionine synthase (2756 A--&gt;G)--an enzyme directly involved in folate and homocysteine metabolism.	Folic Acid	168-174	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	100-119
11080594-1	2000	Methylenetetrahydrofolate reductase (MTHFR), a pivotal enzyme in folate metabolism, regulates the proportional distribution of one-carbon moieties between cellular methylation reactions and nucleic acid synthesis.	Folic Acid	19-25	methylenetetrahydrofolate reductase	Homo sapiens	37-42