PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 1453273-4 1992 In addition, the trans-syn and cis-syn cyclobutane dimers of dCpT were obtained by acetophenone photosensitization and characterized. acetophenone 83-95 synemin Homo sapiens 23-26 8387596-2 1993 A series of progestin 16 alpha, 17 alpha-dioxolane ketals of acetophenone or substituted acetophenones that bind to the progesterone receptor (PgR) with comparable or higher affinities than the natural ligand, progesterone, have been prepared and evaluated as potential in vitro and in vivo probes for the progesterone receptor. acetophenone 61-73 progesterone receptor Homo sapiens 120-141 8387596-2 1993 A series of progestin 16 alpha, 17 alpha-dioxolane ketals of acetophenone or substituted acetophenones that bind to the progesterone receptor (PgR) with comparable or higher affinities than the natural ligand, progesterone, have been prepared and evaluated as potential in vitro and in vivo probes for the progesterone receptor. acetophenone 61-73 progesterone receptor Homo sapiens 143-146 1453273-4 1992 In addition, the trans-syn and cis-syn cyclobutane dimers of dCpT were obtained by acetophenone photosensitization and characterized. acetophenone 83-95 synemin Homo sapiens 35-38 1610807-3 1992 The insertion of a methylene bridge between the phenyl and tetrahydropyridine moieties of MPTP to yield N-methyl-4-benzyl-1,2,3,6-tetrahydropyridine, rendering the molecule more flexible, greatly enhances reactivity with MAO B, but not with MAO A, as compared with MPTP itself, in accord with data in the literature (Youngster et al., 1989a). acetophenone 48-54 monoamine oxidase B Homo sapiens 221-226 1610807-3 1992 The insertion of a methylene bridge between the phenyl and tetrahydropyridine moieties of MPTP to yield N-methyl-4-benzyl-1,2,3,6-tetrahydropyridine, rendering the molecule more flexible, greatly enhances reactivity with MAO B, but not with MAO A, as compared with MPTP itself, in accord with data in the literature (Youngster et al., 1989a). acetophenone 48-54 monoamine oxidase A Homo sapiens 241-246 34450988-8 2021 Three target gases, phenethyl alcohol, acetophenone and anethole, were perfectly discriminated, as the characteristic variables in the response matrix constructed by the combination of gas responses obtained 3 one-layer and 3 two-layer film-coated sensors. acetophenone 39-51 gastrin Homo sapiens 185-188 34111638-4 2021 We hypothesized that studied rhodococcal isolates, besides the regular one, use at least two alternative pathways for PCB transformation, including the pathway leading to acetophenone formation (via 3,4 (4,5) dioxygenase attack on the molecule), and a third sideway pathway that includes stepwise oxidative decarboxylation of the aliphatic side chain of the 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate. acetophenone 171-183 pyruvate carboxylase Homo sapiens 118-121 1315745-1 1992 Recombinant cytochrome c peroxidase (CcP) and a W51A mutant of CcP, in contrast to other classical peroxidases, react with phenylhydrazine to give sigma-bonded phenyl-iron complexes. acetophenone 123-129 cytochrome c, somatic Homo sapiens 12-24 1991108-5 1991 The mechanism of the observed changes in thrombin affinity may involve a reduction in the pK of the hydroxyl group of tyrosine due to substitution of the electrophilic iodo or nitro group on the phenyl ring, resulting in an increased negative charge at neutral pH. acetophenone 195-201 coagulation factor II, thrombin Homo sapiens 41-49 2709330-7 1989 Therefore, the phenyl substitution appears to increase greatly the selectivity of the compound for AChE. acetophenone 15-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 35276362-4 2022 Competitive binding assay of estrogen receptors ERalpha and ERbeta showed that diethanolamine derivative of 4-trifluoromethyl phenyl derivative 30 displayed 77.5-fold strong binding affinity towards ERalpha (IC50 = 0.004 muM) as compared to ERbeta (IC50 = 0.31 muM). acetophenone 126-132 epiregulin Homo sapiens 29-47 35276362-4 2022 Competitive binding assay of estrogen receptors ERalpha and ERbeta showed that diethanolamine derivative of 4-trifluoromethyl phenyl derivative 30 displayed 77.5-fold strong binding affinity towards ERalpha (IC50 = 0.004 muM) as compared to ERbeta (IC50 = 0.31 muM). acetophenone 126-132 estrogen receptor 1 Homo sapiens 48-55 35276362-4 2022 Competitive binding assay of estrogen receptors ERalpha and ERbeta showed that diethanolamine derivative of 4-trifluoromethyl phenyl derivative 30 displayed 77.5-fold strong binding affinity towards ERalpha (IC50 = 0.004 muM) as compared to ERbeta (IC50 = 0.31 muM). acetophenone 126-132 estrogen receptor 1 Homo sapiens 60-66 35276362-4 2022 Competitive binding assay of estrogen receptors ERalpha and ERbeta showed that diethanolamine derivative of 4-trifluoromethyl phenyl derivative 30 displayed 77.5-fold strong binding affinity towards ERalpha (IC50 = 0.004 muM) as compared to ERbeta (IC50 = 0.31 muM). acetophenone 126-132 estrogen receptor 1 Homo sapiens 199-206 35276362-4 2022 Competitive binding assay of estrogen receptors ERalpha and ERbeta showed that diethanolamine derivative of 4-trifluoromethyl phenyl derivative 30 displayed 77.5-fold strong binding affinity towards ERalpha (IC50 = 0.004 muM) as compared to ERbeta (IC50 = 0.31 muM). acetophenone 126-132 estrogen receptor 1 Homo sapiens 241-247 3129035-6 1988 The Km value of phenylalanine for the cytoplasmic form of phenylalanine hydroxylase is 0.32.10(-3) M, that for the membrane form is 1.66.10(-3) M. Both enzyme forms can bind to phenyl-Sepharose after their activation by the substrate, and they dissociate from the carrier after phenylalanine removal from the incubation mixture, which points to the intactness of the phenylalanine binding allosteric center in the membrane form of the enzyme. acetophenone 16-22 phenylalanine hydroxylase Rattus norvegicus 58-83 33885554-4 2021 The results of computations for several potential reaction pathways are juxtaposed with experiment-based calculations, which leads to stepwise mechanisms and energy profiles for the reactions of pinacolborane with benzaldehyde and acetophenone (in the presence of KF). acetophenone 231-243 arylformamidase Homo sapiens 264-266 3103131-2 1987 For example, in a reconstituted system containing rabbit liver microsomal P-450 form 2, NADPH-cytochrome P-450 reductase, and NADPH, cumyl hydroperoxide yields acetophenone and methane, but no cumyl alcohol is formed. acetophenone 160-172 NADPH--cytochrome P450 reductase Oryctolagus cuniculus 88-120 6143758-14 1984 Gel filtration of prereacted mixtures of [U-14C]phenylhydrazine plus hemoproteins resulted in co-chromatography of radioactivity, protein, and guanylate cyclase stimulating activity, and yielded a phenyl-hemoprotein binding stoichiometry of four under specified conditions (one phenyl/heme). acetophenone 48-54 guanylate cyclase Bos taurus 143-160 6699544-1 1984 Previous work has shown that the injection of antiidiotope antibodies specific for idiotopes of the germline-encoded anti-(4-hydroxy-3-nitro-phenyl) acetyl (NP) antibody B1-8 enhanced or suppressed the expression of B1-8 idiotopes in subsequent humoral anti-NP responses, depending on the dose and perhaps also the isotype of the injected antibody. acetophenone 141-147 bradykinin receptor, beta 2 Mus musculus 170-174 6699544-1 1984 Previous work has shown that the injection of antiidiotope antibodies specific for idiotopes of the germline-encoded anti-(4-hydroxy-3-nitro-phenyl) acetyl (NP) antibody B1-8 enhanced or suppressed the expression of B1-8 idiotopes in subsequent humoral anti-NP responses, depending on the dose and perhaps also the isotype of the injected antibody. acetophenone 141-147 bradykinin receptor, beta 2 Mus musculus 216-220 6299382-3 1983 Spin traps were also found to inhibit haemolysis and lipid peroxidation in phenylhydrazine-treated fresh human erythrocytes, with a concomitant production of phenyl radical spin adducts. acetophenone 158-172 spindlin 1 Homo sapiens 0-4 6299382-3 1983 Spin traps were also found to inhibit haemolysis and lipid peroxidation in phenylhydrazine-treated fresh human erythrocytes, with a concomitant production of phenyl radical spin adducts. acetophenone 158-172 spindlin 1 Homo sapiens 173-177 4030762-9 1985 Analyses of products formed from the interaction of cumene hydroperoxide with cytochrome P-450 showed that this substrate undergoes rearrangement also; 2-phenyl-1,2-propanediol was produced, together with cumyl alcohol and acetophenone. acetophenone 223-235 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 78-94 6498204-7 1984 These findings suggest a model in which trehalase has two binding sites at the substrate-binding site, a phlorizin (glucosyl) and a phloretin (phenyl) binding site, analogous to the model proposed previously for the glucose carrier. acetophenone 143-150 trehalase Homo sapiens 40-49 33316359-0 2021 New lignans and acetophenone derivatives with alpha-glucosidase inhibitory activity from the leaves of Melicope patulinervia. acetophenone 16-28 sucrase-isomaltase Homo sapiens 46-63 33260981-1 2020 Kinetic studies and molecular modeling of human acetylcholinesterase (AChE) inhibition by a fluorinated acetophenone derivative, 1-(3-tert-butylphenyl)-2,2,2-trifluoroethanone (TFK), were performed. acetophenone 104-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 32920141-2 2020 Here, a collection of acetylphenol analogues derived from paeonol and acetophenone were synthesized and evaluated for their alpha-glucosidase inhibitory activity. acetophenone 70-82 sucrase-isomaltase Homo sapiens 124-141 33260981-1 2020 Kinetic studies and molecular modeling of human acetylcholinesterase (AChE) inhibition by a fluorinated acetophenone derivative, 1-(3-tert-butylphenyl)-2,2,2-trifluoroethanone (TFK), were performed. acetophenone 104-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 32343561-5 2020 The porphyrin (AlPor, AlPorF3 or AlPorF5) redox potentials are tuned by substitution of phenyl (Ph), 3,4,5-trifluorophenyl (PhF3) or 2,3,4,5,6-pentafluorophenyl (PhF5) groups in its meso positions. acetophenone 88-94 PHD finger protein 3 Homo sapiens 124-128 32911196-5 2020 Utilizing information from molecular modelling of the hybrids to the anti-apoptotic Bcl-2 protein, we added substructures including phenyl, piperazine, piperidine, and morpholine rings to their frameworks. acetophenone 132-138 BCL2 apoptosis regulator Homo sapiens 84-89 32046403-3 2020 Apocynin, acetophenone with anti-oxidative and anti-inflammation activities, has been shown to protect against insulin resistance. acetophenone 10-22 insulin Homo sapiens 111-118 32015097-3 2020 We found Olfr923 to be one of the most sensitive ORs that is enriched by acetophenone. acetophenone 73-85 olfactory receptor family 8 subfamily B member 56 Mus musculus 9-16 32015097-4 2020 Using a mouse line that genetically labels Olfr923-positive axons, we provided evidence that acetophenone activates the Olfr923 glomeruli in the olfactory bulb. acetophenone 93-105 olfactory receptor family 8 subfamily B member 56 Mus musculus 43-50 32015097-4 2020 Using a mouse line that genetically labels Olfr923-positive axons, we provided evidence that acetophenone activates the Olfr923 glomeruli in the olfactory bulb. acetophenone 93-105 olfactory receptor family 8 subfamily B member 56 Mus musculus 120-127 32015097-5 2020 Through molecular dynamics stimulations, we identified amino acid residues in the Olfr923 binding cavity that facilitate acetophenone binding. acetophenone 121-133 olfactory receptor family 8 subfamily B member 56 Mus musculus 82-89 31384834-1 2019 Background: In continuation of our work, new diazenyl chalcones scaffolds (C-18 to C-27) were efficiently synthesized from substituted acetophenone azo dyes (A-E) by base catalyzed Claisen-Schmidt condensation with different substituted aromatic/heteroaromatic aldehydes. acetophenone 135-147 Bardet-Biedl syndrome 9 Homo sapiens 75-79 31072245-0 2019 Benzonate derivatives of acetophenone as potent alpha-glucosidase inhibitors: synthesis, structure-activity relationship and mechanism. acetophenone 25-37 sucrase isomaltase (alpha-glucosidase) Mus musculus 48-65 31575771-6 2019 Murine in vivo and differentiated C2C12 myotube cell studies showed that 2-AA promotes ROS generation in skeletal muscle via the modulation of xanthine oxidase (XO) activity, NAD(P)H oxidase2 (NOX2) protein level, and the activity of antioxidant enzymes. acetophenone 73-77 xanthine dehydrogenase Mus musculus 143-159 31575771-6 2019 Murine in vivo and differentiated C2C12 myotube cell studies showed that 2-AA promotes ROS generation in skeletal muscle via the modulation of xanthine oxidase (XO) activity, NAD(P)H oxidase2 (NOX2) protein level, and the activity of antioxidant enzymes. acetophenone 73-77 cytochrome b-245, beta polypeptide Mus musculus 175-191 31575771-6 2019 Murine in vivo and differentiated C2C12 myotube cell studies showed that 2-AA promotes ROS generation in skeletal muscle via the modulation of xanthine oxidase (XO) activity, NAD(P)H oxidase2 (NOX2) protein level, and the activity of antioxidant enzymes. acetophenone 73-77 cytochrome b-245, beta polypeptide Mus musculus 193-197 30445058-5 2019 ATP and cyclic AMP production by control and OR10G7 small interfering RNA-transfected keratinocytes in response to odorant stimulation with acetophenone and eugenol was assessed. acetophenone 140-152 olfactory receptor family 10 subfamily G member 7 Homo sapiens 45-51 30926317-6 2019 Rabbit DHRS11 also reduced alpha-dicarbonyl compounds, aldehydes and aromatic ketones (acetylbenzenes and acetylpyridines), and exhibited 3(17)beta-hydroxysteroid dehydrogenase activity. acetophenone 87-101 LOW QUALITY PROTEIN: dehydrogenase/reductase SDR family member 11 Oryctolagus cuniculus 7-13 30292395-6 2019 RESULTS: Extinguishing fear toward Ace or Lyral of F0 male mice (F0-Extinguished) that had been fear conditioned with Ace or Lyral, respectively, results in F1-Extinguished offspring that do not demonstrate behavioral sensitivity to Ace or Lyral, respectively, and do not have enhanced representation for M71 or MOR23 odorant receptors in the olfactory system, as is observed in F1-Trained-Ace or F1-Trained-Lyral cohorts, respectively. acetophenone 35-38 olfactory receptor family 8 subfamily A member 1 Mus musculus 305-308 30292395-6 2019 RESULTS: Extinguishing fear toward Ace or Lyral of F0 male mice (F0-Extinguished) that had been fear conditioned with Ace or Lyral, respectively, results in F1-Extinguished offspring that do not demonstrate behavioral sensitivity to Ace or Lyral, respectively, and do not have enhanced representation for M71 or MOR23 odorant receptors in the olfactory system, as is observed in F1-Trained-Ace or F1-Trained-Lyral cohorts, respectively. acetophenone 35-38 olfactory receptor family 10 subfamily J member 5 Mus musculus 312-317 32254242-2 2018 Herein, we synthesized a novel phenyl-substituted imidazole-fused rhodamine analogue RV-1 with a long absorption wavelength at 573 nm and a large Stokes shift of about 82 nm for monitoring the changes in cellular viscosity. acetophenone 31-37 Friend virus susceptibility 1 Mus musculus 85-89 28860658-0 2017 Modification of the response of olfactory receptors to acetophenone by CYP1a2. acetophenone 55-67 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 71-77 29850046-2 2018 Whereas the structure of the methyl-substituted derivative (HATNMe6) contains no solvent mol-ecules (C30H24N6), the hexa-phenyl-substituted structure (HATNPh6) contains two mol-ecules of di-chloro-methane (C60H36N6 2CH2Cl2). acetophenone 121-127 hexosaminidase subunit alpha Homo sapiens 116-120 29250404-1 2017 The condensation reaction of aceto-phenone (1-phenyl-ethan-1-one) with 2-nitro-benzaldehyde in the molten state yielded the expected chalcone, (E)-3-(2-nitro-phen-yl)-1-phenyl-prop-2-en-1-one, and, unexpectedly, the title compound, C30H22N2O6, which results from the syn head-to-head [2 + 2] cyclo-addition of the chalcone. acetophenone 29-42 synemin Homo sapiens 267-270 29250404-1 2017 The condensation reaction of aceto-phenone (1-phenyl-ethan-1-one) with 2-nitro-benzaldehyde in the molten state yielded the expected chalcone, (E)-3-(2-nitro-phen-yl)-1-phenyl-prop-2-en-1-one, and, unexpectedly, the title compound, C30H22N2O6, which results from the syn head-to-head [2 + 2] cyclo-addition of the chalcone. acetophenone 44-64 synemin Homo sapiens 267-270 28860658-5 2017 Among the CYPs tested, co-expression of CYP1a2 significantly affected the responses of various ORs, including MOR161-2, to acetophenone. acetophenone 123-135 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 40-46 28860658-5 2017 Among the CYPs tested, co-expression of CYP1a2 significantly affected the responses of various ORs, including MOR161-2, to acetophenone. acetophenone 123-135 olfactory receptor family 8 subfamily B member 12 Mus musculus 110-118 28860658-6 2017 Conversion of acetophenone to methyl salicylate was observed in the medium of CYP1a2-expressing cells. acetophenone 14-26 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 78-84 28860658-7 2017 MOR161-2-expressing cells exhibited significantly greater responses to methyl salicylate than to acetophenone. acetophenone 97-109 olfactory receptor family 8 subfamily B member 12 Mus musculus 0-8 28860658-9 2017 MOR161-2 responded to both acetophenone and methyl salicylate in vivo. acetophenone 27-39 olfactory receptor family 8 subfamily B member 12 Mus musculus 0-8 28860658-10 2017 When the olfactory mucus was washed out by the injection of PBS to mouse nasal cavity, the response of MOR161-2 to acetophenone was reduced, while that to methyl salicylate did not change. acetophenone 115-127 olfactory receptor family 8 subfamily B member 12 Mus musculus 103-111 28860658-11 2017 Our data suggest that CYP1a2 affects OR activation by converting acetophenone to methyl salicylate. acetophenone 65-77 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 22-28 28240894-4 2017 Here, some prenylated acetophenone dimers from Acronychia pedunculata have been identified for their dual inhibitory potency toward 5-LO and mPGES-1. acetophenone 22-34 prostaglandin E synthase Mus musculus 141-148 28685570-2 2017 This cross-coupling reaction includes the oxidative cleavage of sp2 C-N bonds of phenyl hydrazides to form a phenyl radical and the subsequent N-addition to cyanos to form new sp2 C-N bonds and provides efficient access to various N-phenyl amides in moderate to good yields under mild reaction conditions. acetophenone 109-123 Sp2 transcription factor Homo sapiens 64-67 28685570-2 2017 This cross-coupling reaction includes the oxidative cleavage of sp2 C-N bonds of phenyl hydrazides to form a phenyl radical and the subsequent N-addition to cyanos to form new sp2 C-N bonds and provides efficient access to various N-phenyl amides in moderate to good yields under mild reaction conditions. acetophenone 109-123 Sp2 transcription factor Homo sapiens 176-179 27545873-8 2017 We confirmed acetophenone as a specific TRPA1 agonist that activates the receptor in concentrations >3mM, whereas isophorone specifically activates TRPV1 in concentrations >100muM. acetophenone 13-25 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 40-45 27865994-3 2017 METHODS: We report the synthesis of new phenanthroline, phenyl and quinoline acyclic bisoxazole compounds in order to explore and evaluate the targeting to c-myc and human telomeric repeat 22AG G4 using FRET-melting, CD-melting, NMR, fluorescence titrations and FID assays. acetophenone 56-62 MYC proto-oncogene, bHLH transcription factor Homo sapiens 156-161 30108835-3 2017 Phenyl or pyrazolyl groups were the best in terms of affinity for the sigma1R and the 4-(1-methylpyrazol-5-yl) derivative, 12f, was the most selective. acetophenone 0-6 sigma non-opioid intracellular receptor 1 Mus musculus 70-77 27637382-3 2016 Various fluorinated acetophenone derivatives bind to acetylcholinesterase with high affinity, including 2,2,2-trifluoro-1-(3-dimethylaminophenyl)ethanone (1) and 1-(3-tert-butylphenyl)-2,2,2-trifluoroethanone (2). acetophenone 20-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 27014933-1 2016 This communication describes the two-electron oxidation of ((DIPP)CCC)NiX ((DIPP)CCC = bis(diisopropylphenyl-benzimidazol-2-ylidene)phenyl); X = Cl or Br) with halogen and halogen surrogates to form ((DIPP)CCC)NiX3. acetophenone 102-108 BCL2 interacting protein 3 like Homo sapiens 70-73 27396505-3 2016 Among these, phenyl, 4- and 2-chlorophenyl, 2-methoxyphenyl, 2-pyridyl, and 2-pyrimidyl derivatives 15, 24, 25, and 27-29 displayed nanomolar affinity values for the 5-HT7 receptor (Ki 23.5-52.0nM) and no affinity for the 5-HT1A receptor. acetophenone 13-19 5-hydroxytryptamine receptor 1A Homo sapiens 222-237 27011163-0 2016 Preparation of Pd-Loaded Hierarchical FAU Membranes and Testing in Acetophenone Hydrogenation. acetophenone 67-79 FAU ubiquitin like and ribosomal protein S30 fusion Homo sapiens 38-41 27011163-1 2016 Pd-loaded hierarchical FAU (Pd-FAU) membranes, containing an intrinsic secondary non-zeolitic (meso)porosity, were prepared and tested in the catalytic transfer hydrogenation of acetophenone (AP) to produce phenylethanol (PE), an industrially relevant product. acetophenone 178-190 FAU ubiquitin like and ribosomal protein S30 fusion Homo sapiens 23-26 27011163-1 2016 Pd-loaded hierarchical FAU (Pd-FAU) membranes, containing an intrinsic secondary non-zeolitic (meso)porosity, were prepared and tested in the catalytic transfer hydrogenation of acetophenone (AP) to produce phenylethanol (PE), an industrially relevant product. acetophenone 178-190 FAU ubiquitin like and ribosomal protein S30 fusion Homo sapiens 31-34 26618894-6 2016 Complex [Re(p-NTol)Cl(L(2))(PPh3)2]PF6 (13) is the catalyst of choice for oxidation of 1-phenylethanol to acetophenone (in 80% yield; turnover number attained 290 after 30 h) and cyclooctanol to cyclooctanone (in 88% yield). acetophenone 106-118 protein phosphatase 4 catalytic subunit Homo sapiens 28-32 26618894-6 2016 Complex [Re(p-NTol)Cl(L(2))(PPh3)2]PF6 (13) is the catalyst of choice for oxidation of 1-phenylethanol to acetophenone (in 80% yield; turnover number attained 290 after 30 h) and cyclooctanol to cyclooctanone (in 88% yield). acetophenone 106-118 sperm associated antigen 17 Homo sapiens 35-38 25406399-3 2015 The latter isomerized via the addition of the phenyl radical to the terminal C1/C4 carbon atoms through submerged barriers forming resonantly stabilized free radicals C11H13, which then underwent cis-trans isomerization followed by ring closure. acetophenone 46-60 heterogeneous nuclear ribonucleoprotein C Homo sapiens 77-82 26473832-6 2015 Flavonoid glucosides and acetophenone derivatives showed aldose reductase and alpha-glucosidase inhibition, and could explain the traditional use of Myrcia species to treat diabetes. acetophenone 25-37 aldo-keto reductase family 1 member B Homo sapiens 57-73 26473832-6 2015 Flavonoid glucosides and acetophenone derivatives showed aldose reductase and alpha-glucosidase inhibition, and could explain the traditional use of Myrcia species to treat diabetes. acetophenone 25-37 sucrase-isomaltase Homo sapiens 78-95 25611197-2 2015 The new well-defined [Ni(IPr*)(cin)Cl] (1 c) pre-catalyst showed great efficiency for this transformation, allowing the coupling of a wide range of ketones, including acetophenone derivatives, with various functionalised aryl chlorides. acetophenone 167-179 pyridoxal phosphatase Homo sapiens 31-34 25877513-6 2015 Superior adsorption was dominated by various interaction modes including pi-pi electron donor-acceptor interactions between the pi-electron-deficient phenyls of the NACs and the pi-electron-rich matrix of the graphene nanosheets, and the charge electrostatic and polar interactions between the defect sites of graphene nanosheets and the -NO2 of the NAC. acetophenone 150-157 synuclein alpha Homo sapiens 165-168 24884962-2 2014 The reaction of phenyl with 1,2-butadiene is initiated by adding the phenyl radical with its radical center to the pi electron density at the C1/C3 carbon atom of 1,2-butadiene. acetophenone 16-22 heterogeneous nuclear ribonucleoprotein C Homo sapiens 142-147 24928349-8 2014 Activation of P2X1 receptors had more profound inhibitory effects on benzaldehyde-evoked intracellular calcium elevation than on acetophenone-evoked responses within the same neurons, and the reverse was true when P2Y2 receptors were activated. acetophenone 129-141 purinergic receptor P2X 1 Homo sapiens 14-18 25014710-1 2014 The first asymmetric gamma-alkoxyallylboration of representative ketones provides beta-alkoxy tert-homoallylic alcohols 10 whose diastereoselectivities range from 99% syn (acetophenone) to 99% anti (pinacolone) both with high ee (>95%). acetophenone 172-184 synemin Homo sapiens 167-170 24577918-6 2014 In addition, HPRT assay showed the mutagenic effect of photosensitizer, acetophenone. acetophenone 72-84 hypoxanthine-guanine phosphoribosyltransferase Cricetulus griseus 13-17 24695705-5 2014 Here we exposed MOR23-green fluorescent protein (GFP) and M71-GFP mice to lyral or acetophenone, ligands for MOR23 or M71, respectively. acetophenone 83-95 olfactory receptor family 10 subfamily J member 5 Mus musculus 109-114 24695705-5 2014 Here we exposed MOR23-green fluorescent protein (GFP) and M71-GFP mice to lyral or acetophenone, ligands for MOR23 or M71, respectively. acetophenone 83-95 olfactory receptor 7 complex Mus musculus 118-121 24078149-4 2014 The second couples the CV2025 omega-TAm with alcohol dehydrogenase and glucose dehydrogenase for removal of the acetophenone (AP) by-product by in situ conversion to (R)-1-phenylethanol. acetophenone 112-124 hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase Homo sapiens 71-92 22833116-1 2012 Cage dodecaphenylsilsesquioxane (T12-Phenyl) was synthesized in a one batch, mildly basic aqueous solution under room temperature conditions using a trialkoxysilane precursor. acetophenone 37-43 CD6 molecule Homo sapiens 33-36 23802426-0 2013 Design, synthesis, and biological evaluation of acetophenone derivatives as dual binding acetylcholinesterase inhibitors. acetophenone 48-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-109 23802426-1 2013 As part of a project aimed at developing new agents for potential application in Alzheimer"s disease, a new series of acetophenone derivatives which possess alkylamine side chains were designed, synthesized and assayed as acetylcholinesterase (AChE) inhibitors that could simultaneously bind to the peripheral and catalytic sites of the enzyme. acetophenone 118-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 222-242 23802426-1 2013 As part of a project aimed at developing new agents for potential application in Alzheimer"s disease, a new series of acetophenone derivatives which possess alkylamine side chains were designed, synthesized and assayed as acetylcholinesterase (AChE) inhibitors that could simultaneously bind to the peripheral and catalytic sites of the enzyme. acetophenone 118-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 244-248 23426982-4 2013 We find that the debromination reaction results from the electronic transitions from pi to sigma* orbitals when nona-BDEs are exposed to UV-light in the sunlight region, at which point the two low-lying excited states for each nona-BDE are pisigma*(5Br) and pisigma*(4Br), which correlate to the sigma* orbitals located on the penta-Br and tetra-Br substituted phenyls, respectively. acetophenone 361-368 homeobox D13 Homo sapiens 117-120 23585037-4 2013 Furthermore, this expression and functional system has been used to show that the preincubation of Human Odorant Binding Protein 2A decrease the calcium response of OR 17-210 following stimulation by acetophenone and beta ionone. acetophenone 200-212 odorant binding protein 2A Homo sapiens 105-131 24292232-3 2014 When an odor (acetophenone) that activates a known odorant receptor (Olfr151) was used to condition F0 mice, the behavioral sensitivity of the F1 and F2 generations to acetophenone was complemented by an enhanced neuroanatomical representation of the Olfr151 pathway. acetophenone 14-26 olfactory receptor family 6 subfamily F member 2 Mus musculus 51-67 24292232-3 2014 When an odor (acetophenone) that activates a known odorant receptor (Olfr151) was used to condition F0 mice, the behavioral sensitivity of the F1 and F2 generations to acetophenone was complemented by an enhanced neuroanatomical representation of the Olfr151 pathway. acetophenone 14-26 olfactory receptor family 8 subfamily A member 1 Mus musculus 69-76 24292232-3 2014 When an odor (acetophenone) that activates a known odorant receptor (Olfr151) was used to condition F0 mice, the behavioral sensitivity of the F1 and F2 generations to acetophenone was complemented by an enhanced neuroanatomical representation of the Olfr151 pathway. acetophenone 14-26 olfactory receptor family 8 subfamily A member 1 Mus musculus 251-258 24292232-3 2014 When an odor (acetophenone) that activates a known odorant receptor (Olfr151) was used to condition F0 mice, the behavioral sensitivity of the F1 and F2 generations to acetophenone was complemented by an enhanced neuroanatomical representation of the Olfr151 pathway. acetophenone 168-180 olfactory receptor family 6 subfamily F member 2 Mus musculus 51-67 24292232-3 2014 When an odor (acetophenone) that activates a known odorant receptor (Olfr151) was used to condition F0 mice, the behavioral sensitivity of the F1 and F2 generations to acetophenone was complemented by an enhanced neuroanatomical representation of the Olfr151 pathway. acetophenone 168-180 olfactory receptor family 8 subfamily A member 1 Mus musculus 69-76 23458186-0 2013 Bis(oxazolinyl)phenyl-ligated rare-earth-metal complexes: highly regioselective catalysts for cis-1,4-polymerization of isoprene. acetophenone 15-21 cytokine inducible SH2 containing protein Homo sapiens 94-99 22532294-7 2012 Concerted coordination of acetophenone and dual hydrogen-atom transfer from the PNP arm and the coordinated ethanol to, respectively, the carbonyl carbon and oxygen atoms, leads to the dearomatized complex [(iPr-PNP*)Fe(CO)(EtO)(MeCH(OH)Ph)] (32). acetophenone 26-38 RUNX1 partner transcriptional co-repressor 1 Homo sapiens 224-227 22497458-3 2012 The reaction is initiated by a barrierless addition of the phenyl radical to the terminal carbon atom of the 1,3-butadiene (C1/C4) to form a bound intermediate; the latter underwent hydrogen elimination from the terminal CH(2) group of the 1,3-butadiene molecule leading to 1-phenyl-trans-1,3-butadiene through a submerged barrier. acetophenone 59-73 heterogeneous nuclear ribonucleoprotein C Homo sapiens 124-129 21615508-1 2011 Two natural acetophenone derivatives, 2,5-dihydroxyacetophenone (2,5-DHAP) and 2,6-DHAP, were purified from Cynanchum bungei and identified as murine tyrosinase inhibitors. acetophenone 12-24 tyrosinase Mus musculus 150-160 22429107-6 2012 The modeling results indicated that the concentration of acetylene and propargyl radicals, the main PAH precursors, as well as the PAH amounts were lower in the flame of the ethanol-benzene fuel mixture than in the pure benzene flame and that all of the formed PAHs were issued from the phenyl radical. acetophenone 287-301 phenylalanine hydroxylase Homo sapiens 131-134 21671642-7 2011 Since it has been proposed that the phenyl radical metabolite leads to protein radical formation on MPO, we investigated the effect of LA and DHA in immuno-spin trapping experiments with MPO-containing HL-60 cell lysate. acetophenone 36-50 myeloperoxidase Homo sapiens 100-103 21675799-2 2011 The turnover frequency of the hydrogenation of acetophenone reaches about 35,000 min(-1) in the best case, affording 1-phenylethanol in >99% ee. acetophenone 47-59 CD59 molecule (CD59 blood group) Homo sapiens 81-87 19233899-3 2009 The 3"-C-branched p-methylphenyl (compound 1) and 3-CF(3)-4-Cl-phenyl (compound 7) thiourea derivatives of beta-dThd showed competitive inhibition of TK-2 when dThd was used as the variable substrate (K(i) values, 0.40 and 0.05 microM, respectively), but uncompetitive inhibition in the presence of variable concentrations of ATP (K(i) values, 15 and 2.0 microM, respectively). acetophenone 26-32 thymidine kinase 2 Homo sapiens 150-154 20026676-6 2010 Here, we identify six different SNPs that are associated with variation in responses to a structurally similar odorant, acetophenone, in the same Obp genes. acetophenone 120-132 Optix-binding protein Drosophila melanogaster 146-149 20026676-8 2010 We found that the 610G allele is associated with higher response scores to acetophenone than the 610A allele, but with lower expression of Obp99a, suggesting that binding of acetophenone to Opb99a might limit rather than facilitate access to odorant receptors. acetophenone 174-186 Odorant-binding protein 99a Drosophila melanogaster 139-145 21582758-2 2009 The benzene ring of the hexa-hydro-pyrroloisoquinoline ring system makes dihedral angles of 83.43 (6) and 61.99 (10) , respectively, with the phenyl and pyrrole rings. acetophenone 142-148 hexosaminidase subunit alpha Homo sapiens 24-28 21837179-1 2011 In the title compound, C(24)H(25)NO, the phenyl and diphenyl-methanol substituents are syn to each other. acetophenone 41-47 synemin Homo sapiens 87-90 20199096-2 2010 We have previously shown that the metabolism of two aromatic amine drugs by human myeloperoxidase (MPO) results in phenyl radical metabolite formation and also in protein free radical formation on MPO. acetophenone 115-129 myeloperoxidase Homo sapiens 82-97 20199096-2 2010 We have previously shown that the metabolism of two aromatic amine drugs by human myeloperoxidase (MPO) results in phenyl radical metabolite formation and also in protein free radical formation on MPO. acetophenone 115-129 myeloperoxidase Homo sapiens 99-102 20199096-10 2010 Interestingly, we found that only those aniline derivatives that produced a phenyl radical also formed MPO*. acetophenone 76-90 myeloperoxidase Homo sapiens 103-106 20199096-11 2010 We propose that the phenyl radical is the reactive free radical metabolite responsible for generating the MPO*. acetophenone 20-34 myeloperoxidase Homo sapiens 106-110 19928821-1 2010 Singlet-singlet energy transfer in self-assembled via axial coordination of imidazole-appended (at different positions of one of the meso-phenyl entities) free-base tetraphenylporphyrin, H(2)PIm, to either zinc phthalocyanine, ZnPc, or zinc naphthalocyanine, ZnNc, dyads is investigated in noncoordinating solvents, o-dichlorobenzene and toluene, using both steady-state and time-resolved transient absorption techniques. acetophenone 138-144 Pim-1 proto-oncogene, serine/threonine kinase Homo sapiens 191-194 20024111-5 2009 Barriers to rotation around the syn phenyl-imino bond are also reported (10.5-11.1 kcal mol(-1)). acetophenone 36-42 synemin Homo sapiens 32-35 19407445-2 2009 METHODS: An initial structure-activity relationship study of the NF-kappaB inhibitory activity of acetophenone-type compounds using electrophoretic mobility shift assay and Western blot analysis is presented. acetophenone 98-110 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 65-74 19052201-4 2008 Transgenic mice labeled at the M71 odorant receptor (specifically activated by the odorant acetophenone) were behaviorally trained with olfactory-dependent fear conditioning or conditioned place preference using acetophenone. acetophenone 91-103 olfactory receptor family 8 subfamily A member 1 Mus musculus 31-51 19109912-5 2008 The M71 transgenic mice readily detect other odors in the presence of acetophenone. acetophenone 70-82 olfactory receptor 7 complex Mus musculus 4-7 18318476-6 2008 The DFT-PBE results suggest that this reaction is driven to the (R)-product only by the process of binding the acetophenone to the active site of the trans-Ru(H) 2(S, S-dpen)(S-tolbinap) catalyst. acetophenone 111-123 enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase Homo sapiens 8-11 18489081-9 2008 The DMPO adducts of MPO metabolism, as analyzed by electron spin resonance spectroscopy, included a nitrogen-centered radical and a phenyl radical derived from PA, either of which may be involved in the free radical formation on MPO. acetophenone 132-146 myeloperoxidase Homo sapiens 5-8 18489081-9 2008 The DMPO adducts of MPO metabolism, as analyzed by electron spin resonance spectroscopy, included a nitrogen-centered radical and a phenyl radical derived from PA, either of which may be involved in the free radical formation on MPO. acetophenone 132-146 myeloperoxidase Homo sapiens 20-23 17602675-8 2007 When analyzed by electron spin resonance spectroscopy, we detected a phenyl radical adduct, derived from AG, which may be involved in the free radical formation on MPO. acetophenone 69-83 myeloperoxidase Homo sapiens 164-167 18006320-1 2008 Stereoselective reductive metabolism of various p-substituted acetophenone derivatives was studied using isolated rat liver 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD). acetophenone 62-74 aldo-keto reductase family 1, member C14 Rattus norvegicus 124-159 18006320-1 2008 Stereoselective reductive metabolism of various p-substituted acetophenone derivatives was studied using isolated rat liver 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD). acetophenone 62-74 aldo-keto reductase family 1, member C14 Rattus norvegicus 161-171 18006776-1 2007 PURPOSE: 1,1-Bis(3"-indolyl)-1-(p-substitutedphenyl)methanes [methylene-substituted diindolylmethanes (C-DIM)] containing p-trifluoromethyl, p-t-butyl, and p-phenyl substituents activate peroxisome proliferator-activated receptor gamma (PPARgamma) and inhibit growth of several different cancer cell lines through receptor-dependent and receptor-independent pathways. acetophenone 45-51 peroxisome proliferator activated receptor gamma Homo sapiens 187-235 18006776-1 2007 PURPOSE: 1,1-Bis(3"-indolyl)-1-(p-substitutedphenyl)methanes [methylene-substituted diindolylmethanes (C-DIM)] containing p-trifluoromethyl, p-t-butyl, and p-phenyl substituents activate peroxisome proliferator-activated receptor gamma (PPARgamma) and inhibit growth of several different cancer cell lines through receptor-dependent and receptor-independent pathways. acetophenone 45-51 peroxisome proliferator activated receptor gamma Homo sapiens 237-246 18242988-2 2008 Systematic modification of the benzimidazole core and tethered acetophenone moiety established tractable SAR of analogs with improved physicochemical properties and sub-micromolar activity across both human and murine receptors. acetophenone 63-75 sarcosine dehydrogenase Homo sapiens 105-108 19202742-1 2008 Some acetophenone (CAS 98-86-2) derived bis Mannich bases, bis-(3-aryl-3-oxo-propyl)-methylamine hydrochlorides (B1-B5) and representative piperidinols, 4-aryl-3-arylcarbonyl-1-methyl-4-piperidinol hydrochlorides (C1, C2 and C5), which are the structural isomers of B1, B2 and B5, were synthesized and their effects on DNA topoisomerase I were tested. acetophenone 5-17 immunoglobulin kappa variable 7-3 (pseudogene) Homo sapiens 266-279 17226937-6 2007 In the proposed reaction mechanism, the active-site cysteine residue of GSTO1-1 reacts with the S-(phenacyl)glutathione substrate to give an acetophenone and a mixed disulfide with the active-site cysteine; a second thiol substrate (e.g., glutathione or 2-mercaptoethanol) reacts with the active-site disulfide to regenerate the catalytically active enzyme and to form a mixed disulfide. acetophenone 141-153 glutathione S-transferase omega 1 Rattus norvegicus 72-79 17441044-0 2006 Mechanism of asymmetric hydrogenation of acetophenone catalyzed by chiral eta(6)-arene-N-tosylethylenediamine-ruthenium(II) complexes. acetophenone 41-53 endothelin receptor type A Homo sapiens 74-77 17441044-2 2006 [Ru(OSO2CF3){(S,S)-TsNCH(C6H5)CH(C6H5)NH2}(eta(6)-p-cymene)] catalyzes the asymmetric hydrogenation of acetophenone in methanol to afford (S)-1-phenylethanol with 96% ee in 100% yield. acetophenone 103-115 endothelin receptor type A Homo sapiens 43-46 16448083-1 2006 An acetophenone containing PNA-based reagent was designed for the direct and site-specific synthesis of a cis-syn thymidine dimer lesion in genomic DNA. acetophenone 3-15 synemin Homo sapiens 91-94 15604828-3 2004 Using this whole-cell biocatalyst, efficient conversion of prochiral ketones to chiral alcohols was achieved: 66% acetophenone was reduced to (R)-phenylethanol over 12 h, whereas only 19% (R)-phenylethanol was formed under the same conditions with cells containing ADH and FDH genes but without PNT genes. acetophenone 114-126 alcohol dehydrogenase 5 (class III), chi polypeptide Homo sapiens 273-276 16298757-10 2006 ESR spin-trapping experiments showed that the phenyl radical was formed during the reaction of 4-hydrazinobenzoic acid in the presence of Cu(II) and catalase. acetophenone 46-60 catalase Bos taurus 149-157 16397256-1 2006 1,1-Bis(3"-indolyl)-1-(p-substitutedphenyl)methanes containing p-trifluoromethyl (DIM-C-pPhCF3), p-t-butyl (DIM-C-pPhtBu), and phenyl (DIM-C-pPhC6H5) substituents have been identified as a new class of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists that exhibit antitumorigenic activity. acetophenone 36-42 peroxisome proliferator activated receptor gamma Homo sapiens 202-250 16397256-1 2006 1,1-Bis(3"-indolyl)-1-(p-substitutedphenyl)methanes containing p-trifluoromethyl (DIM-C-pPhCF3), p-t-butyl (DIM-C-pPhtBu), and phenyl (DIM-C-pPhC6H5) substituents have been identified as a new class of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists that exhibit antitumorigenic activity. acetophenone 36-42 peroxisome proliferator activated receptor gamma Homo sapiens 252-261 15792487-8 2005 The dihydrides containing amino groups and cis-PPh3 groups, i.e., c,c-2a or c,c-2b, are active precatalysts for the H2-hydrogenation of acetophenone (neat or in benzene) under mild reaction conditions, whereas those with trans-PPh3 groups, c,t-2a and c,t-2b are much less active. acetophenone 136-148 protein phosphatase 4 catalytic subunit Homo sapiens 47-51 15792487-8 2005 The dihydrides containing amino groups and cis-PPh3 groups, i.e., c,c-2a or c,c-2b, are active precatalysts for the H2-hydrogenation of acetophenone (neat or in benzene) under mild reaction conditions, whereas those with trans-PPh3 groups, c,t-2a and c,t-2b are much less active. acetophenone 136-148 secretoglobin family 2B member 3, pseudogene Homo sapiens 78-82 15792487-8 2005 The dihydrides containing amino groups and cis-PPh3 groups, i.e., c,c-2a or c,c-2b, are active precatalysts for the H2-hydrogenation of acetophenone (neat or in benzene) under mild reaction conditions, whereas those with trans-PPh3 groups, c,t-2a and c,t-2b are much less active. acetophenone 136-148 protein phosphatase 4 catalytic subunit Homo sapiens 227-231 12027671-10 2002 The transformation of p-quinone 2 into acetophenone 3 might contribute to the chemistry of tocopherols oxidized at C-4, i.e., 4-hydroxy-alpha-tocopherol and 4-oxo-alpha-tocopherol, which have been proposed as precursors of natural vitamin E metabolites. acetophenone 39-51 complement C4A (Rodgers blood group) Homo sapiens 115-118 12478754-1 2002 Exposure of tertiary thioamides to (E)-1-hexenyl(phenyl)-lambda 3-iodane results in vinylic SN2 reaction to give the inverted (Z)-S-vinylthioimidonium salts, which under alkaline hydrolysis (Na2CO3 or K2CO3) selectively afford amides, while (Z)-S-vinyl thioesters are obtained in high yields via the hydrolysis under acidic conditions (HCl). acetophenone 49-56 solute carrier family 38 member 5 Homo sapiens 92-95 11806709-4 2002 Increasing the size of the RHS sulfonamide substituent with phenyl or p-toluene afforded compounds with good potency and functional selectivity (beta(3) AR pEC(50) greater than 8; beta(1) and beta(2) AR selectivity greater than 40- and 500-fold, respectively). acetophenone 60-66 adrenergic receptor, beta 3 Mus musculus 145-155 11029216-2 2000 Photolysis of mercaptoundecanophenone-modified gold colloid, MUP-MPC, generates free acetophenone in solution and the nonene-modified MPC via the triplet excited state and the 1,4-biradical intermediate. acetophenone 85-97 major urinary protein, pseudogene Homo sapiens 61-64 12572525-1 2002 Some acetophenone derived bis Mannich bases (B1-B5) and piperidinols (C1, C4), which are the structural isomers of B1 and B4, and also quaternary piperidine derivative C6 were synthesized and studied for anticonvulsant activity. acetophenone 5-17 immunoglobulin kappa variable 7-3 (pseudogene) Homo sapiens 115-124 11812825-5 2001 It is concluded that acetophenone derivatives, which produce radicals upon photolysis, in particular the hydroxy (AP-OH) and tert-butoxy (AP-O(t)Bu) derivatives, are more effective in oxidizing DNA. acetophenone 21-33 aminopeptidase O (putative) Homo sapiens 114-118 8824622-3 1996 In anaerobic suspensions of strain EB1 cells metabolizing ethylbenzene, the transient formation and consumption of 1-phenylethanol, acetophenone, and an as yet unidentified compound were observed. acetophenone 132-144 microtubule associated protein RP/EB family member 1 Homo sapiens 35-38 10537071-5 1999 The binding of zinc by the small myelin-associated glycoprotein induces a conformational change that enables the protein to reversibly bind to a hydrophobic phenyl-Sepharose matrix. acetophenone 157-163 myelin associated glycoprotein Homo sapiens 33-63 10222230-2 1999 Demethylation activities of either truncated 2B4 with N-methylaniline, N,N-dimethylaniline, and d-benzphetamine were lower than those of liver microsomal 2B4, whereas the rate of 1-phenylethanol oxidation to acetophenone catalyzed by liver microsomal and truncated 2B4 enzymes was nearly the same. acetophenone 208-220 CD244 molecule Homo sapiens 45-48 9655332-1 1998 We have determined the 2.5 A structure (Rcryst = 20.5%, Rfree = 28.5%) of a complex between human cathepsin S and the potent, irreversible inhibitor 4-morpholinecarbonyl-Phe-hPhe-vinyl sulfone-phenyl. acetophenone 193-199 cathepsin S Homo sapiens 98-109 10482506-12 1999 strain EB1 cells that were grown anaerobically on ethylbenzene, 1-phenylethanol, and acetophenone, but these activities were absent in benzoate-grown cells. acetophenone 85-97 microtubule associated protein RP/EB family member 1 Homo sapiens 7-10 10941798-5 1999 These results suggest that strain EbN1 degrades ethylbenzene via 1-phenylethanol and acetophenone as intermediates, and that acetophenone is subsequently carboxylated. acetophenone 85-97 potassium voltage-gated channel subfamily Q member 2 Homo sapiens 34-38 10941798-5 1999 These results suggest that strain EbN1 degrades ethylbenzene via 1-phenylethanol and acetophenone as intermediates, and that acetophenone is subsequently carboxylated. acetophenone 125-137 potassium voltage-gated channel subfamily Q member 2 Homo sapiens 34-38 10941798-8 1999 In accordance with our findings from these studies, two-dimensional gel electrophoretic analysis of extracts of cells grown on benzoate, acetophenone, ethylbenzene, or toluene showed that a number of substrate-specific proteins were induced in strain EbN1. acetophenone 137-149 potassium voltage-gated channel subfamily Q member 2 Homo sapiens 251-255