PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
29377234-3	2018	In the present study, we found that SNHG1 expression was remarkably increased both in isolated cerebral micro-vessels of a middle cerebral artery occlusion (MCAO) mice model, and in oxygen-glucose deprivation (OGD)-cultured mice brain micro-vascular endothelial cells (BMECs), meanwhile, the SNHG1 level was negatively correlated with miR-18a in MCAO mice.	oxygen-glucose	182-196	small nucleolar RNA host gene 1	Mus musculus	36-41
29570780-10	2018	In vitro, postconditoning after oxygen-glucose deprivation up-regulated VEGF release in primary neuron cultures, and adding VEGF to microglial cultures partly shifted their M2-like markers.	oxygen-glucose	32-46	vascular endothelial growth factor A	Rattus norvegicus	72-76
29912587-2	2018	Here, we demonstrate that GIT1 deficiency remarkably increased neuronal apoptosis and enhanced JNK/p38 signaling, which resulted in stronger motor deficits by ischemia-reperfusion in vivo, consistent with the finding of oxygen-glucose deprivation/reoxygenation-induced neuronal injury in vitro.	oxygen-glucose	220-234	GIT ArfGAP 1	Homo sapiens	26-30
29945912-0	2018	Inhibition of MicroRNA-155 Supports Endothelial Tight Junction Integrity Following Oxygen-Glucose Deprivation.	oxygen-glucose	83-97	microRNA 155	Homo sapiens	14-26
29945912-12	2018	CONCLUSIONS: Based on these results, we conclude that miR-155 inhibition-induced strengthening of endothelial tight junctions after oxygen-glucose deprivation is mediated via its direct target protein claudin-1.	oxygen-glucose	132-146	microRNA 155	Homo sapiens	54-61
29945912-12	2018	CONCLUSIONS: Based on these results, we conclude that miR-155 inhibition-induced strengthening of endothelial tight junctions after oxygen-glucose deprivation is mediated via its direct target protein claudin-1.	oxygen-glucose	132-146	claudin 1	Homo sapiens	201-210
29624520-0	2018	Inhibition of microRNA-429 attenuates oxygen-glucose deprivation/reoxygenation-induced neuronal injury by promoting expression of GATA-binding protein 4.	oxygen-glucose	38-52	GATA binding protein 4	Homo sapiens	130-152
29624520-5	2018	In this study, the effect of miR-429 on oxygen-glucose deprivation and reoxygenation (OGD/R)-induced neuronal injury was investigated in vitro.	oxygen-glucose	40-54	microRNA 429	Homo sapiens	29-36
29724989-0	2018	Role of Hypoxia-Inducible Factors 1alpha (HIF1alpha) in SH-SY5Y Cell Autophagy Induced by Oxygen-Glucose Deprivation.	oxygen-glucose	90-104	hypoxia inducible factor 1 subunit alpha	Homo sapiens	8-51
29867110-5	2018	We further showed that inhibition of succinate release and GPR91 signaling ameliorated oxygen-glucose deprivation-induced injury in cardiomyocytes and isoproterenol-induced myocardial ischemia injury in mice.	oxygen-glucose	87-101	succinate receptor 1	Mus musculus	59-64
29789575-5	2018	MCU knockdown by siRNA-induced silencing in cortical neuron cultures also reduced cell death and mitochondrial respiratory deficits following oxygen-glucose deprivation.	oxygen-glucose	142-156	mitochondrial calcium uniporter	Mus musculus	0-3
29891768-4	2018	Previously, our lab identified metastasis associates lung adenocarcinoma transcript 1 (Malat1) as an oxygen-glucose deprivation (OGD)-responsive endothelial lncRNA.	oxygen-glucose	101-115	metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)	Mus musculus	87-93
29236326-0	2018	Knockdown of Ski decreased the reactive astrocytes proliferation in vitro induced by oxygen-glucose deprivation/reoxygenation.	oxygen-glucose	85-99	SKI proto-oncogene	Homo sapiens	13-16
29236326-6	2018	This study is to elucidate the role of Ski in reactive astrocytes induced by oxygen-glucose deprivation/reoxygenation (OGD/R) model in vitro.	oxygen-glucose	77-91	SKI proto-oncogene	Homo sapiens	39-42
29849883-0	2018	GRP78 Promotes Neural Stem Cell Antiapoptosis and Survival in Response to Oxygen-Glucose Deprivation (OGD)/Reoxygenation through PI3K/Akt, ERK1/2, and NF-kappaB/p65 Pathways.	oxygen-glucose	74-88	heat shock protein family A (Hsp70) member 5	Homo sapiens	0-5
29544396-0	2018	Pitavastatin treatment induces neuroprotection through the BDNF-TrkB signalling pathway in cultured cerebral neurons after oxygen-glucose deprivation.	oxygen-glucose	123-137	brain derived neurotrophic factor	Homo sapiens	59-63
29172440-0	2018	Mitochondrial GSH Systems in CA1 Pyramidal Cells and Astrocytes React Differently during Oxygen-Glucose Deprivation and Reperfusion.	oxygen-glucose	89-103	carbonic anhydrase 1	Homo sapiens	29-32
29526759-4	2018	Activation of A2AR in vitro not only decreased the PKA- and glutamate level-dependent strengthening of the interaction between NKA-alpha1 and the FXYD1 subunit and the subsequent decrease in the activity of Na+/K+-ATPases (NKAs) but also enhanced its interaction with EAATs and ultimately aggravated the reverse transport function of endothelial EAATs under oxygen-glucose deprivation (OGD) conditions.	oxygen-glucose	358-372	adenosine A2a receptor	Homo sapiens	14-18
29526759-4	2018	Activation of A2AR in vitro not only decreased the PKA- and glutamate level-dependent strengthening of the interaction between NKA-alpha1 and the FXYD1 subunit and the subsequent decrease in the activity of Na+/K+-ATPases (NKAs) but also enhanced its interaction with EAATs and ultimately aggravated the reverse transport function of endothelial EAATs under oxygen-glucose deprivation (OGD) conditions.	oxygen-glucose	358-372	FXYD domain containing ion transport regulator 1	Homo sapiens	146-151
29849883-3	2018	Here in this study, we established an in vitro oxygen-glucose deprivation (OGD)/reoxygenation model on NSCs and detected glucose-regulated protein 78 (GRP78) involved in apoptosis, while in the absence of GRP78 by siRNA transfection, OGD/reoxygenation triggered PI3K/Akt, ERK1/2, and NF-kappaB/p65 activation, and induced NSC apoptosis was attenuated.	oxygen-glucose	47-61	mitogen-activated protein kinase 3	Homo sapiens	272-278
29849883-3	2018	Here in this study, we established an in vitro oxygen-glucose deprivation (OGD)/reoxygenation model on NSCs and detected glucose-regulated protein 78 (GRP78) involved in apoptosis, while in the absence of GRP78 by siRNA transfection, OGD/reoxygenation triggered PI3K/Akt, ERK1/2, and NF-kappaB/p65 activation, and induced NSC apoptosis was attenuated.	oxygen-glucose	47-61	heat shock protein family A (Hsp70) member 5	Homo sapiens	121-149
29849883-3	2018	Here in this study, we established an in vitro oxygen-glucose deprivation (OGD)/reoxygenation model on NSCs and detected glucose-regulated protein 78 (GRP78) involved in apoptosis, while in the absence of GRP78 by siRNA transfection, OGD/reoxygenation triggered PI3K/Akt, ERK1/2, and NF-kappaB/p65 activation, and induced NSC apoptosis was attenuated.	oxygen-glucose	47-61	heat shock protein family A (Hsp70) member 5	Homo sapiens	151-156
29849883-3	2018	Here in this study, we established an in vitro oxygen-glucose deprivation (OGD)/reoxygenation model on NSCs and detected glucose-regulated protein 78 (GRP78) involved in apoptosis, while in the absence of GRP78 by siRNA transfection, OGD/reoxygenation triggered PI3K/Akt, ERK1/2, and NF-kappaB/p65 activation, and induced NSC apoptosis was attenuated.	oxygen-glucose	47-61	heat shock protein family A (Hsp70) member 5	Homo sapiens	205-210
29849883-3	2018	Here in this study, we established an in vitro oxygen-glucose deprivation (OGD)/reoxygenation model on NSCs and detected glucose-regulated protein 78 (GRP78) involved in apoptosis, while in the absence of GRP78 by siRNA transfection, OGD/reoxygenation triggered PI3K/Akt, ERK1/2, and NF-kappaB/p65 activation, and induced NSC apoptosis was attenuated.	oxygen-glucose	47-61	nuclear factor kappa B subunit 1	Homo sapiens	284-293
29849883-3	2018	Here in this study, we established an in vitro oxygen-glucose deprivation (OGD)/reoxygenation model on NSCs and detected glucose-regulated protein 78 (GRP78) involved in apoptosis, while in the absence of GRP78 by siRNA transfection, OGD/reoxygenation triggered PI3K/Akt, ERK1/2, and NF-kappaB/p65 activation, and induced NSC apoptosis was attenuated.	oxygen-glucose	47-61	AKT serine/threonine kinase 1	Homo sapiens	267-270
29849883-3	2018	Here in this study, we established an in vitro oxygen-glucose deprivation (OGD)/reoxygenation model on NSCs and detected glucose-regulated protein 78 (GRP78) involved in apoptosis, while in the absence of GRP78 by siRNA transfection, OGD/reoxygenation triggered PI3K/Akt, ERK1/2, and NF-kappaB/p65 activation, and induced NSC apoptosis was attenuated.	oxygen-glucose	47-61	RELA proto-oncogene, NF-kB subunit	Homo sapiens	294-297
29424025-0	2018	Nrf2-mediated neuroprotection against oxygen-glucose deprivation/reperfusion injury by emodin via AMPK-dependent inhibition of GSK-3beta.	oxygen-glucose	38-52	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
29457851-0	2018	Suppression of microRNA-144-3p attenuates oxygen-glucose deprivation/reoxygenation-induced neuronal injury by promoting Brg1/Nrf2/ARE signaling.	oxygen-glucose	42-56	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	120-124
29457851-0	2018	Suppression of microRNA-144-3p attenuates oxygen-glucose deprivation/reoxygenation-induced neuronal injury by promoting Brg1/Nrf2/ARE signaling.	oxygen-glucose	42-56	NFE2 like bZIP transcription factor 2	Homo sapiens	125-129
29424025-0	2018	Nrf2-mediated neuroprotection against oxygen-glucose deprivation/reperfusion injury by emodin via AMPK-dependent inhibition of GSK-3beta.	oxygen-glucose	38-52	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	98-102
29252510-8	2018	N-Myc downstream-regulated gene-2 lentiviral knockdown reduced the oxygen-glucose deprivation-induced secretion of proinflammatory cytokines.	oxygen-glucose	67-81	N-myc downstream regulated gene 2	Mus musculus	0-33
29212895-12	2018	Silencing neuraminidase-1, the enzyme that regulates Neu5Ac generation, ameliorated oxygen-glucose deprivation-induced injury in cardiomyocytes and ligation/isoprenaline-induced myocardial ischemia injury in rats.	oxygen-glucose	84-98	neuraminidase 1	Rattus norvegicus	10-25
29425821-0	2018	MMP9 is involved in HO-1-mediated upregulation of apical junctional complex in Caco-2 cells under oxygen-glucose deprivation.	oxygen-glucose	98-112	matrix metallopeptidase 9	Homo sapiens	0-4
29425821-0	2018	MMP9 is involved in HO-1-mediated upregulation of apical junctional complex in Caco-2 cells under oxygen-glucose deprivation.	oxygen-glucose	98-112	heme oxygenase 1	Homo sapiens	20-24
29425821-2	2018	This study was the first to explore the expression of apical junctional complex (AJC) induced by heme oxygenase-1 (HO-1) in Caco-2 cells in oxygen-glucose deprivation (OGD) models.	oxygen-glucose	140-154	heme oxygenase 1	Homo sapiens	97-113
29425821-2	2018	This study was the first to explore the expression of apical junctional complex (AJC) induced by heme oxygenase-1 (HO-1) in Caco-2 cells in oxygen-glucose deprivation (OGD) models.	oxygen-glucose	140-154	heme oxygenase 1	Homo sapiens	115-119
29581894-6	2018	Exposure of primary cortical neurons cultures to 4 h of oxygen-glucose deprivation (OGD) resulted in neuronal cell death and induced Cdk1 expression.	oxygen-glucose	56-70	cyclin-dependent kinase 1	Mus musculus	133-137
29103101-4	2018	In the present study, we investigated the effects of Nrf2 on (i) IPC-induced protection of astrocytes; (ii) OXPHOS protein expression; and (iii) mitochondrial supercomplex formation.Oxygen-glucose deprivation (OGD) was used as an in vitro model of cerebral ischemia and IPC in cultured rodent astrocytes derived from WT C57Bl/6J and Nrf2-/- mice.	oxygen-glucose	182-196	nuclear factor, erythroid derived 2, like 2	Mus musculus	53-57
29461605-2	2018	Also, the effect of miR-210 on the apoptosis of cardiomyocytes induced by oxygen-glucose deprivation/reperfusion (OGD/R) and its mechanism through establishing the OGD/R injury model of primary cardiomyocytes in this experiment were investigated.	oxygen-glucose	74-88	microRNA 210	Homo sapiens	20-27
29087603-0	2018	MiR-29b expression is associated with a dexmedetomidine-mediated protective effect against oxygen-glucose deprivation-induced injury to SK-N-SH cells in vitro.	oxygen-glucose	91-105	microRNA 29b-1	Homo sapiens	0-7
29416029-5	2018	Ngb overexpression promoted while Ngb knockdown suppressed axon regeneration as well as GAP43 expression in neurons during oxygen-glucose deprivation/reoxygenation (OGD/Re).	oxygen-glucose	123-137	neuroglobin	Homo sapiens	34-37
29205833-9	2018	An increase in MCT1 expression was detected in OPCs after a mild oxygen-glucose deprivation.	oxygen-glucose	65-79	solute carrier family 16 member 1	Homo sapiens	15-19
29258823-3	2018	We showed that RMST expression level was significantly up-regulated in oxygen-glucose deprivation (OGD)-treated primary hippocampal neuron, MCAO-induced injured brain, and the plasma of patients with ischemic stroke.	oxygen-glucose	71-85	rhabdomyosarcoma 2 associated transcript	Homo sapiens	15-19
29210287-0	2018	Dexmedetomidine protects against oxygen-glucose deprivation/reoxygenation injury-induced apoptosis via the p38 MAPK/ERK signalling pathway.	oxygen-glucose	33-47	mitogen-activated protein kinase 14	Mus musculus	107-115
29210287-0	2018	Dexmedetomidine protects against oxygen-glucose deprivation/reoxygenation injury-induced apoptosis via the p38 MAPK/ERK signalling pathway.	oxygen-glucose	33-47	mitogen-activated protein kinase 1	Mus musculus	116-119
29442011-3	2018	In the present study, we aim to investigate whether AP inhibited HMGB1 release in oxygen-glucose deprivation (OGD)-treated BV2 microglia.	oxygen-glucose	82-96	high mobility group box 1	Rattus norvegicus	65-70
29449802-10	2018	We found that SPARC levels are increased in astrocytes and microglia following middle cerebral artery occlusion (MCAO) in vivo and oxygen-glucose deprivation (OGD) in vitro.	oxygen-glucose	131-145	secreted protein acidic and cysteine rich	Homo sapiens	14-19
29057768-11	2018	In conclusion, our data suggest that ghrelin protects adult rat hippocampal NSCs from excessive autophagy in experimental stroke (oxygen-glucose deprivation) model.	oxygen-glucose	130-144	ghrelin and obestatin prepropeptide	Rattus norvegicus	37-44
29621765-5	2018	Additionally, the influence of Nrf2 expression on NOX pathway activation was measured in PMVECs after oxygen-glucose deprivation/reoxygenation.	oxygen-glucose	102-116	nuclear factor, erythroid derived 2, like 2	Mus musculus	31-35
30071537-0	2018	Heat Shock Protein B8 (HSPB8) Reduces Oxygen-Glucose Deprivation/Reperfusion Injury via the Induction of Mitophagy.	oxygen-glucose	38-52	heat shock protein 8	Mus musculus	0-21
30071537-0	2018	Heat Shock Protein B8 (HSPB8) Reduces Oxygen-Glucose Deprivation/Reperfusion Injury via the Induction of Mitophagy.	oxygen-glucose	38-52	heat shock protein 8	Mus musculus	23-28
30071537-1	2018	BACKGROUND/AIMS: We have reported the neuroprotective properties of Heat shock protein B8(HSPB8) against oxygen-glucose deprivation/reoxygenation (OGD/R)-induced injury by inhibiting the mitochondrial apoptotic pathway.	oxygen-glucose	105-119	heat shock protein 8	Mus musculus	68-89
30071537-1	2018	BACKGROUND/AIMS: We have reported the neuroprotective properties of Heat shock protein B8(HSPB8) against oxygen-glucose deprivation/reoxygenation (OGD/R)-induced injury by inhibiting the mitochondrial apoptotic pathway.	oxygen-glucose	105-119	heat shock protein 8	Mus musculus	90-95
29203245-1	2018	In this study, we investigated the expression profile and functional role of Kruppel-like family of transcription factor 4 (KLF4) in mouse cerebral microvascular endothelial cells (MECs) after focal cerebral ischemia and in cultured b.End3 cells after oxygen-glucose deprivation (OGD).	oxygen-glucose	252-266	Kruppel-like factor 4 (gut)	Mus musculus	124-128
29969783-3	2018	METHODS: The spatio-temporal changes in expression of endothelial FKBP25 upon oxygen-glucose deprivation (OGD) treatment were examined by Western blot and immunofluorescence.	oxygen-glucose	78-92	FKBP prolyl isomerase 3	Homo sapiens	66-72
29621765-11	2018	Furthermore, Nrf2 knockdown suppressed cell viability, capillary tube formation and cell migration in PMVECs after oxygen-glucose deprivation/reoxygenation and also inhibited NOX4, HIF-1 and VEGF expression.	oxygen-glucose	115-129	nuclear factor, erythroid derived 2, like 2	Mus musculus	13-17
29207398-2	2018	In the present study, the influences of ginsenosides Rb1 and Rb3 on N-methyl-D-aspartic acid (NMDA) receptor or DL-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor-mediated synaptic transmission after oxygen-glucose deprivation (OGD) were investigated.	oxygen-glucose	226-240	stathmin 4	Rattus norvegicus	61-64
29732997-6	2018	The anti-inflammatory effect of HSYA was partially reversed by TLR9-siRNA interference in primary microglia, which was stimulated by oxygen-glucose deprivation and reoxygenation treatment.	oxygen-glucose	133-147	toll-like receptor 9	Rattus norvegicus	63-67
28956063-4	2018	MATERIALS AND METHODS: BV2 microglial cells were pretreated with tert-butylhydroquinone or Nrf2 CRISPR plasmid before oxygen-glucose deprivation/reoxygenation (OGDR) exposure.	oxygen-glucose	118-132	nuclear factor, erythroid derived 2, like 2	Mus musculus	91-95
29045036-3	2018	RESULTS: Oxygen-glucose deprivation induced time-dependent death in SH-SY5Y cells, which was accompanied with upregulation of PARP-1, accumulation of PAR polymer, decline of mitochondrial membrane potentials and nuclear translocation of AIF.	oxygen-glucose	9-23	poly(ADP-ribose) polymerase 1	Homo sapiens	126-132
28322445-8	2018	In response to in vitro oxygen-glucose deprivation (OGD), IL10 overexpression in MSC (Ad.IL10-MSC) enhanced cell viability, decreased apoptosis, and increased IL10 secretion.	oxygen-glucose	24-38	interleukin 10	Rattus norvegicus	58-62
28322445-8	2018	In response to in vitro oxygen-glucose deprivation (OGD), IL10 overexpression in MSC (Ad.IL10-MSC) enhanced cell viability, decreased apoptosis, and increased IL10 secretion.	oxygen-glucose	24-38	musculin	Rattus norvegicus	81-84
28322445-8	2018	In response to in vitro oxygen-glucose deprivation (OGD), IL10 overexpression in MSC (Ad.IL10-MSC) enhanced cell viability, decreased apoptosis, and increased IL10 secretion.	oxygen-glucose	24-38	musculin	Rattus norvegicus	86-97
29100648-13	2017	RESULTS: EPO preserved neuronal viability after oxygen-glucose deprivation (0.82 +- 0.04 versus 0.61 +- 0.01; p < 0.01).	oxygen-glucose	48-62	erythropoietin	Mus musculus	9-12
29100648-16	2017	CONCLUSIONS: EPO attenuates neuronal loss after oxygen-glucose deprivation in a betacR-dependent fashion.	oxygen-glucose	48-62	erythropoietin	Mus musculus	13-16
27796760-4	2017	SIRT2 was upregulated in ischemic neurons in the oxygen-glucose deprivation cell model and in the transient middle cerebral artery occlusion (tMCAo) mouse model.	oxygen-glucose	49-63	sirtuin 2	Mus musculus	0-5
29243790-1	2017	OBJECTIVE: To identify the expression changes of microRNA 93 (miR-93) in oxygen-glucose deprivation/reoxygenation (OGD/R) injury in cardiomyocytes and its mechanism of mediating OGD/R and inducing apoptosis.	oxygen-glucose	73-87	microRNA 9-3	Homo sapiens	49-60
29243790-1	2017	OBJECTIVE: To identify the expression changes of microRNA 93 (miR-93) in oxygen-glucose deprivation/reoxygenation (OGD/R) injury in cardiomyocytes and its mechanism of mediating OGD/R and inducing apoptosis.	oxygen-glucose	73-87	microRNA 9-3	Homo sapiens	62-68
29077414-4	2017	A plausible biogenetic pathway for 1 was proposed, and 1 showed neuroprotective effects against oxygen-glucose deprivation (OGD)-induced cell injury in SH-SY5Y cells with an EC50 value of 27.72 muM.	oxygen-glucose	96-110	latexin	Homo sapiens	194-197
28888980-5	2017	Furthermore, we also investigated whether ARC protected against cerebral ischemia via SIRT1-dependent inhibition of NLRP3 inflammasome by administrating EX527, a specific SIRT1 inhibitor, under oxygen-glucose deprivation (OGD) condition.	oxygen-glucose	194-208	sirtuin 1	Rattus norvegicus	86-91
28751019-6	2017	Consistently, when cultured microglia were polarized toward a pro-inflammatory phenotype with conditioned medium collected from neurons that had been subjected to oxygen-glucose deprivation (OGD neuron CM), they displayed reduced CBS expression and H2S production.	oxygen-glucose	163-177	cystathionine beta-synthase	Mus musculus	230-233
29039534-0	2017	Apurinic/apyrimidinic endonuclease 1 (APE1) contributes to resveratrol-induced neuroprotection against oxygen-glucose deprivation and re-oxygenation injury in HT22 cells: Involvement in reducing oxidative DNA damage.	oxygen-glucose	103-117	apurinic/apyrimidinic endonuclease 1	Mus musculus	0-36
29039534-0	2017	Apurinic/apyrimidinic endonuclease 1 (APE1) contributes to resveratrol-induced neuroprotection against oxygen-glucose deprivation and re-oxygenation injury in HT22 cells: Involvement in reducing oxidative DNA damage.	oxygen-glucose	103-117	apurinic/apyrimidinic endonuclease 1	Mus musculus	38-42
29178911-0	2017	Inhibition of HMGB1 reduces rat spinal cord astrocytic swelling and AQP4 expression after oxygen-glucose deprivation and reoxygenation via TLR4 and NF-kappaB signaling in an IL-6-dependent manner.	oxygen-glucose	90-104	high mobility group box 1	Rattus norvegicus	14-19
29178911-0	2017	Inhibition of HMGB1 reduces rat spinal cord astrocytic swelling and AQP4 expression after oxygen-glucose deprivation and reoxygenation via TLR4 and NF-kappaB signaling in an IL-6-dependent manner.	oxygen-glucose	90-104	aquaporin 4	Rattus norvegicus	68-72
29178911-3	2017	Given this, we sought to identify both the role and underlying mechanisms of HMGB1 in cellular swelling and aquaporin 4 (AQP4) expression in cultured rat spinal cord astrocytes after oxygen-glucose deprivation/reoxygenation (OGD/R).	oxygen-glucose	183-197	high mobility group box 1	Rattus norvegicus	77-82
29104282-11	2017	CONCLUSIONS Tetramethylpyrazine can protect neurons from oxygen-glucose deprivation-induced death, possibly via TRPC6.	oxygen-glucose	57-71	transient receptor potential cation channel, subfamily C, member 6	Rattus norvegicus	112-117
28731692-3	2017	The previous reported ROS-trapping compound, quinolyl nitrone RP19, is here being assayed to induce neuroprotection to ischemia-reperfusion injury in three experimental ischemia models: (i) oxygen-glucose deprivation (OGD) on primary neuronal cultures; (ii) transient global cerebral ischemia in four-vessel occlusion model; and (iii) transient focal cerebral ischemia in middle cerebral artery occlusion (tMCAO) model.	oxygen-glucose	190-204	ATP binding cassette subfamily A member 4	Homo sapiens	62-66
29221205-3	2017	The present study assessed the efficacy of thrombospondin-1 (TSP-1), a neurite outgrowth-promoting molecule, modified bone marrow mesenchymal stem cells (BMSCs) on promoting neurite outgrowth in vitro and in vivo of Oxygen-Glucose Deprivation (OGD) treated motor neurons and SCI rat models.	oxygen-glucose	216-230	thrombospondin 1	Rattus norvegicus	43-59
29221205-3	2017	The present study assessed the efficacy of thrombospondin-1 (TSP-1), a neurite outgrowth-promoting molecule, modified bone marrow mesenchymal stem cells (BMSCs) on promoting neurite outgrowth in vitro and in vivo of Oxygen-Glucose Deprivation (OGD) treated motor neurons and SCI rat models.	oxygen-glucose	216-230	thrombospondin 1	Rattus norvegicus	61-66
28928282-5	2017	Checkpoint kinase 1 (Chk1) pathway activation during the S phase prevented the cell death, and allowed the division of cortical neurons that had undergone acute Rb family inactivation, oxygen-glucose deprivation (OGD) or in vivo hypoxia-ischemia.	oxygen-glucose	185-199	checkpoint kinase 1	Mus musculus	0-19
29037241-10	2017	In the primary cultured astrocytes, the expressions of KCa3.1 and TRPV4 were increased associated with upregulation of astrogliosis marker GFAP induced by oxygen-glucose deprivation.	oxygen-glucose	155-169	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	Mus musculus	55-61
29037241-10	2017	In the primary cultured astrocytes, the expressions of KCa3.1 and TRPV4 were increased associated with upregulation of astrogliosis marker GFAP induced by oxygen-glucose deprivation.	oxygen-glucose	155-169	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	66-71
29037241-10	2017	In the primary cultured astrocytes, the expressions of KCa3.1 and TRPV4 were increased associated with upregulation of astrogliosis marker GFAP induced by oxygen-glucose deprivation.	oxygen-glucose	155-169	glial fibrillary acidic protein	Mus musculus	139-143
28981095-4	2017	Using a combination of rat middle cerebral artery occlusion (MCAO) stroke and oxygen-glucose deprivation followed by reoxygenation (OGD/R) models, we determined that the expression of RTN1-C was significantly increased during cerebral ischemic/reperfusion.	oxygen-glucose	78-92	reticulon 1	Rattus norvegicus	184-188
28708281-0	2017	Cooperation of HIF- and NCAM-mediated mechanisms in cell viability of hippocampal cultures after oxygen-glucose deprivation.	oxygen-glucose	97-111	neural cell adhesion molecule 1	Homo sapiens	24-28
28928282-5	2017	Checkpoint kinase 1 (Chk1) pathway activation during the S phase prevented the cell death, and allowed the division of cortical neurons that had undergone acute Rb family inactivation, oxygen-glucose deprivation (OGD) or in vivo hypoxia-ischemia.	oxygen-glucose	185-199	checkpoint kinase 1	Mus musculus	21-25
28630232-11	2017	BV2 cell-based experiments showed that H19 knockdown blocked oxygen-glucose deprivation-driven M1 microglial polarization, decreased production of tumor necrosis factor-alpha and CD11b, and increased the expression of Arg-1 and CD206.	oxygen-glucose	61-75	H19, imprinted maternally expressed transcript	Mus musculus	39-42
28627974-0	2017	MicroRNA-132 protects hippocampal neurons against oxygen-glucose deprivation-induced apoptosis.	oxygen-glucose	50-64	microRNA 132	Rattus norvegicus	0-12
28627974-2	2017	In this study, we investigated the effects of microRNA-132 (miR-132) dysregulation on oxygen-glucose deprivation (OGD)-induced apoptosis in fetal rat hippocampal neurons, in order to reveal the therapeutic potential of miR-132 on HIBI.	oxygen-glucose	86-100	microRNA 132	Rattus norvegicus	46-58
28627974-2	2017	In this study, we investigated the effects of microRNA-132 (miR-132) dysregulation on oxygen-glucose deprivation (OGD)-induced apoptosis in fetal rat hippocampal neurons, in order to reveal the therapeutic potential of miR-132 on HIBI.	oxygen-glucose	86-100	microRNA 132	Rattus norvegicus	60-67
28460604-6	2017	RESULTS: Oxygen-glucose deprivation increased cellular expression of 15-LO-1 and VEGF.	oxygen-glucose	9-23	vascular endothelial growth factor A	Rattus norvegicus	81-85
28347817-0	2017	Activation of Wnt3alpha/beta-catenin signal pathway attenuates apoptosis of the cerebral microvascular endothelial cells induced by oxygen-glucose deprivation.	oxygen-glucose	132-146	Wnt family member 3A	Homo sapiens	14-23
28347817-0	2017	Activation of Wnt3alpha/beta-catenin signal pathway attenuates apoptosis of the cerebral microvascular endothelial cells induced by oxygen-glucose deprivation.	oxygen-glucose	132-146	catenin beta 1	Homo sapiens	24-36
28347817-3	2017	Here, we found that oxygen-glucose deprivation (OGD) could induce apoptosis of BMECs with Wnt3a mRNA expression decrease.	oxygen-glucose	20-34	Wnt family member 3A	Homo sapiens	90-95
28656194-0	2017	Excessive nNOS/NO/AMPK signaling activation mediated by the blockage of the CBS/H2S system contributes to oxygen-glucose deprivation-induced endoplasmic reticulum stress in PC12 cells.	oxygen-glucose	106-120	nitric oxide synthase 1	Homo sapiens	10-14
28656194-0	2017	Excessive nNOS/NO/AMPK signaling activation mediated by the blockage of the CBS/H2S system contributes to oxygen-glucose deprivation-induced endoplasmic reticulum stress in PC12 cells.	oxygen-glucose	106-120	cystathionine beta synthase	Rattus norvegicus	76-79
28656194-5	2017	We found that oxygen-glucose deprivation (OGD) markedly increased the NO level and neuronal NO synthase (nNOS) activity.	oxygen-glucose	14-28	nitric oxide synthase 1	Rattus norvegicus	105-109
28374134-0	2017	The p38/CYLD Pathway is Involved in Necroptosis Induced by Oxygen-glucose Deprivation Combined with ZVAD in Primary Cortical Neurons.	oxygen-glucose	59-73	mitogen-activated protein kinase 14	Homo sapiens	4-7
28374134-0	2017	The p38/CYLD Pathway is Involved in Necroptosis Induced by Oxygen-glucose Deprivation Combined with ZVAD in Primary Cortical Neurons.	oxygen-glucose	59-73	CYLD lysine 63 deubiquitinase	Homo sapiens	8-12
28700093-4	2017	In vitro oxygen-glucose deprivation (OGD) induced IL-10 release from astrocytes but not from neurons.	oxygen-glucose	9-23	interleukin 10	Rattus norvegicus	50-55
28912678-2	2017	An oxygen-glucose deprivation (OGD) model showed that IL-17A expression was significantly up-regulated in microglial cells.	oxygen-glucose	3-17	interleukin 17A	Homo sapiens	54-60
28374134-3	2017	In the following study, we show oxygen-glucose deprivation (OGD) combined with a caspase inhibitor, ZVAD (OGD/ZVAD), induced CYLD protein expression in a time-dependent manner.	oxygen-glucose	32-46	fibroblast growth factor receptor 1	Homo sapiens	60-63
28374134-3	2017	In the following study, we show oxygen-glucose deprivation (OGD) combined with a caspase inhibitor, ZVAD (OGD/ZVAD), induced CYLD protein expression in a time-dependent manner.	oxygen-glucose	32-46	fibroblast growth factor receptor 1	Homo sapiens	106-114
28374134-3	2017	In the following study, we show oxygen-glucose deprivation (OGD) combined with a caspase inhibitor, ZVAD (OGD/ZVAD), induced CYLD protein expression in a time-dependent manner.	oxygen-glucose	32-46	CYLD lysine 63 deubiquitinase	Homo sapiens	125-129
28630232-11	2017	BV2 cell-based experiments showed that H19 knockdown blocked oxygen-glucose deprivation-driven M1 microglial polarization, decreased production of tumor necrosis factor-alpha and CD11b, and increased the expression of Arg-1 and CD206.	oxygen-glucose	61-75	mannose receptor, C type 1	Mus musculus	228-233
28630232-12	2017	Furthermore, H19 knockdown reversed oxygen-glucose deprivation-induced upregulation of HDAC1 and downregulation of acetyl-histone H3 and acetyl-histone H4.	oxygen-glucose	36-50	H19, imprinted maternally expressed transcript	Mus musculus	13-16
28630232-12	2017	Furthermore, H19 knockdown reversed oxygen-glucose deprivation-induced upregulation of HDAC1 and downregulation of acetyl-histone H3 and acetyl-histone H4.	oxygen-glucose	36-50	histone deacetylase 1	Mus musculus	87-92
28522551-4	2017	In vivo middle cerebral artery occlusion (MCAO) and ex vivo oxygen-glucose deprivation (OGD) results showed that miR-143 was significantly induced by ischemia injury.	oxygen-glucose	60-74	microRNA 143	Rattus norvegicus	113-120
28552673-5	2017	Oxygen-glucose deprivation (OGD) was conducted after Srxn1 knockdown.	oxygen-glucose	0-14	sulfiredoxin 1	Rattus norvegicus	53-58
28591721-3	2017	Co-immunoprecipitation showed that Drp1 binding to GSK-3beta was increased after an oxygen-glucose deprivation/reperfusion (OGD/R) insult in cultured neuroblastoma cells.	oxygen-glucose	84-98	collapsin response mediator protein 1	Mus musculus	35-39
28591721-3	2017	Co-immunoprecipitation showed that Drp1 binding to GSK-3beta was increased after an oxygen-glucose deprivation/reperfusion (OGD/R) insult in cultured neuroblastoma cells.	oxygen-glucose	84-98	glycogen synthase kinase 3 beta	Mus musculus	51-60
28398927-7	2017	After oxygen-glucose deprivation, triggering receptor expressed on myeloid cells 2 conferred neuroprotection by regulating the phenotypic conversion of microglia and inflammatory cytokine release.	oxygen-glucose	6-20	triggering receptor expressed on myeloid cells 2	Mus musculus	34-82
28444132-8	2017	In cardiomyocytes subjected to oxidative stress or oxygen-glucose deprivation, inhibition of PYK2 limited cell injury; this effect was prevented by inhibition of NO production.	oxygen-glucose	51-65	PTK2 protein tyrosine kinase 2 beta	Mus musculus	93-97
28550144-0	2017	Exacerbation of oxygen-glucose deprivation-induced blood-brain barrier disruption: potential pathogenic role of interleukin-9 in ischemic stroke.	oxygen-glucose	16-30	interleukin 9	Homo sapiens	112-125
28433650-0	2017	Long noncoding RNA Malat1 is a potent autophagy inducer protecting brain microvascular endothelial cells against oxygen-glucose deprivation/reoxygenation-induced injury by sponging miR-26b and upregulating ULK2 expression.	oxygen-glucose	113-127	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	19-25
28592261-2	2017	Here, we found that the transcriptional and post-transcriptional levels of TREM2 were increased in cultured primary microglia after oxygen-glucose deprivation and reoxygenation and in the ischemic penumbra of the cerebral cortex after middle cerebral artery occlusion (MCAO) and reperfusion in mice.	oxygen-glucose	132-146	triggering receptor expressed on myeloid cells 2	Mus musculus	75-80
28587384-5	2017	In the present study, the effect of BYHWD containing serum (BYHWD-CS) on GLT-1/GS levels in astrocytes following oxygen-glucose deprivation/reoxygenation (OGD/R) was investigated.	oxygen-glucose	113-127	solute carrier family 1 member 2	Homo sapiens	73-81
28535644-0	2017	[Effect of neuroglobin on oxygen-glucose deprivation and reoxygenation induced autophagy in a human neuroblastoma cell line].	oxygen-glucose	26-40	neuroglobin	Homo sapiens	11-22
28535644-1	2017	Objective: To investigate the effect of neuroglobin on oxygen-glucose deprivation and reoxygenation (OGD/R) induced autophagy in a human neuroblastoma cell line (SH-SY5Y).	oxygen-glucose	55-69	neuroglobin	Homo sapiens	40-51
28002622-0	2017	Inhibition of soluble epoxide hydrolase augments astrocyte release of vascular endothelial growth factor and neuronal recovery after oxygen-glucose deprivation.	oxygen-glucose	133-147	epoxide hydrolase 2	Rattus norvegicus	14-39
27021024-7	2017	GSRd improved neuron survival and decreased neuron apoptosis and the level of caspase-3 under oxygen-glucose deprivation/reoxygenation (OGD/R) by upregulation of BDNF as well as in vitro.	oxygen-glucose	94-108	caspase 3	Mus musculus	78-87
28400714-0	2017	Deletion of TRPC6 Attenuates NMDA Receptor-Mediated Ca2+ Entry and Ca2+-Induced Neurotoxicity Following Cerebral Ischemia and Oxygen-Glucose Deprivation.	oxygen-glucose	126-140	transient receptor potential cation channel, subfamily C, member 6	Mus musculus	12-17
28400714-2	2017	In this study, the role of TRPC6 was investigated following ischemia/reperfusion (I/R) and oxygen-glucose deprivation (OGD).	oxygen-glucose	91-105	transient receptor potential cation channel, subfamily C, member 6	Mus musculus	27-32
28057538-0	2017	Neuropeptide Y Y2 and Y5 receptors as promising targets for neuroprotection in primary neurons exposed to oxygen-glucose deprivation and in transient focal cerebral ischemia in rats.	oxygen-glucose	106-120	neuropeptide Y	Rattus norvegicus	0-14
28057538-3	2017	Our in vitro findings showed that NPY (0.5-1muM) and specific agonists of Y2R (0.1-1muM) and Y5R (0.5-1muM) but not that of Y1R produced neuroprotective effects against oxygen-glucose deprivation (OGD)-induced neuronal cell death, being also effective when given 30min after the end of OGD.	oxygen-glucose	169-183	neuropeptide Y	Rattus norvegicus	34-37
28559999-0	2017	Hypoxia-inducible factor 1 alpha protects mesenchymal stem cells against oxygen-glucose deprivation-induced injury via autophagy induction and PI3K/AKT/mTOR signaling pathway.	oxygen-glucose	73-87	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-32
28559999-0	2017	Hypoxia-inducible factor 1 alpha protects mesenchymal stem cells against oxygen-glucose deprivation-induced injury via autophagy induction and PI3K/AKT/mTOR signaling pathway.	oxygen-glucose	73-87	AKT serine/threonine kinase 1	Homo sapiens	148-151
28559999-0	2017	Hypoxia-inducible factor 1 alpha protects mesenchymal stem cells against oxygen-glucose deprivation-induced injury via autophagy induction and PI3K/AKT/mTOR signaling pathway.	oxygen-glucose	73-87	mechanistic target of rapamycin kinase	Homo sapiens	152-156
28559999-3	2017	In this study, we investigated the role of hypoxia-inducible factor 1 alpha (Hif-1alpha) in oxygen-glucose deprivation (OGD)-induced injury in MSCs.	oxygen-glucose	92-106	hypoxia inducible factor 1 subunit alpha	Homo sapiens	43-75
28559999-3	2017	In this study, we investigated the role of hypoxia-inducible factor 1 alpha (Hif-1alpha) in oxygen-glucose deprivation (OGD)-induced injury in MSCs.	oxygen-glucose	92-106	hypoxia inducible factor 1 subunit alpha	Homo sapiens	77-87
28284343-3	2017	In this study, we found that suppression of Sphk1 decreased IL17 production and relieved neuronal damage induced by microglia in cerebral ischemia reperfusion (IR) or in an in vitro oxygen-glucose deprivation reperfusion (OGDR) system.	oxygen-glucose	182-196	sphingosine kinase 1	Homo sapiens	44-49
28002622-3	2017	We found that addition of sEH inhibitors to rat cultured astrocytes immediately after oxygen-glucose deprivation (OGD) markedly increased VEGF concentration in the medium 48 h later and the effect was blocked by an EET antagonist.	oxygen-glucose	86-100	epoxide hydrolase 2	Rattus norvegicus	26-29
28131165-0	2017	Protective effects of ginsenoside Rg1 against oxygen-glucose-deprivation-induced apoptosis in neural stem cells.	oxygen-glucose	46-60	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	34-37
28222148-2	2017	This study was trying to investigate whether miR-200a, a vital regulator in cell proliferation, migration and apoptosis, also has a role in oxygen-glucose deprivation/reperfusion (OGD/R) injured NSCs.	oxygen-glucose	140-154	microRNA 200a	Homo sapiens	45-53
28013092-0	2017	Overexpression of Mitofusin2 decreased the reactive astrocytes proliferation in vitro induced by oxygen-glucose deprivation/reoxygenation.	oxygen-glucose	97-111	mitofusin 2	Homo sapiens	18-28
28069924-1	2017	The present study focuses on the function of cpg15, a neurotrophic factor, in ischemic neuronal recovery using transient global cerebral ischemic (TGI) mouse model and oxygen-glucose deprivation (OGD)-treated primary cultured cells.	oxygen-glucose	168-182	neuritin 1	Mus musculus	45-50
28013092-3	2017	This study is to elucidate the role of Mfn2 in reactive astrocytes induced by oxygen-glucose deprivation/reoxygenation(OGD/R) model in vitro.	oxygen-glucose	78-92	mitofusin 2	Homo sapiens	39-43
28424784-0	2017	Evaluation of Connexin 43 Redistribution and Endocytosis in Astrocytes Subjected to Ischemia/Reperfusion or Oxygen-Glucose Deprivation and Reoxygenation.	oxygen-glucose	108-122	gap junction protein alpha 1	Homo sapiens	14-25
28400812-1	2017	We previously found that oxygen-glucose-serum deprivation/restoration (OGSD/R) induces apoptosis of spinal cord astrocytes, possibly via caspase-12 and the integrated stress response, which involves protein kinase R-like endoplasmic reticulum kinase (PERK), eukaryotic initiation factor 2-alpha (eIF2alpha) and activating transcription factor 4 (ATF4).	oxygen-glucose	25-39	caspase 12	Rattus norvegicus	137-147
28400812-1	2017	We previously found that oxygen-glucose-serum deprivation/restoration (OGSD/R) induces apoptosis of spinal cord astrocytes, possibly via caspase-12 and the integrated stress response, which involves protein kinase R-like endoplasmic reticulum kinase (PERK), eukaryotic initiation factor 2-alpha (eIF2alpha) and activating transcription factor 4 (ATF4).	oxygen-glucose	25-39	eukaryotic translation initiation factor 2A	Rattus norvegicus	296-305
28400812-1	2017	We previously found that oxygen-glucose-serum deprivation/restoration (OGSD/R) induces apoptosis of spinal cord astrocytes, possibly via caspase-12 and the integrated stress response, which involves protein kinase R-like endoplasmic reticulum kinase (PERK), eukaryotic initiation factor 2-alpha (eIF2alpha) and activating transcription factor 4 (ATF4).	oxygen-glucose	25-39	activating transcription factor 4	Rattus norvegicus	311-344
28400812-1	2017	We previously found that oxygen-glucose-serum deprivation/restoration (OGSD/R) induces apoptosis of spinal cord astrocytes, possibly via caspase-12 and the integrated stress response, which involves protein kinase R-like endoplasmic reticulum kinase (PERK), eukaryotic initiation factor 2-alpha (eIF2alpha) and activating transcription factor 4 (ATF4).	oxygen-glucose	25-39	activating transcription factor 4	Rattus norvegicus	346-350
28245468-11	2017	NF-kappaB inhibitor BAY 11-7082 blocked the changes caused by RKIP down-regulation after oxygen-glucose deprivation (OGD).	oxygen-glucose	89-103	phosphatidylethanolamine binding protein 1	Homo sapiens	62-66
28957797-0	2017	Resveratrol Enhances Neurite Outgrowth and Synaptogenesis Via Sonic Hedgehog Signaling Following Oxygen-Glucose Deprivation/Reoxygenation Injury.	oxygen-glucose	97-111	sonic hedgehog signaling molecule	Homo sapiens	62-76
28854438-6	2017	RESULTS: We found that MALAT1, along with the levels of conversion from autophagy-related protein microtubule-associated protein light chain 3-I (LC3-I) to LC3-phosphatidylethanolamine conjugate (LC3-II), as well as Beclin1 were up-regulated and miR-30a was down-regulated in cerebral cortex neurons after oxygen-glucose deprivation (OGD) and mouse brain cortex after middle cerebral artery occlusion-reperfusion (MCAO).	oxygen-glucose	306-320	metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)	Mus musculus	23-29
27693696-5	2016	We found NLRP2 protein had a basal level of expression in CNS, mainly in astrocytes and was significantly elevated in ischemic brains in vivo or oxygen-glucose deprivation-treated cells in vitro.	oxygen-glucose	145-159	NLR family, pyrin domain containing 2	Mus musculus	9-14
28854438-6	2017	RESULTS: We found that MALAT1, along with the levels of conversion from autophagy-related protein microtubule-associated protein light chain 3-I (LC3-I) to LC3-phosphatidylethanolamine conjugate (LC3-II), as well as Beclin1 were up-regulated and miR-30a was down-regulated in cerebral cortex neurons after oxygen-glucose deprivation (OGD) and mouse brain cortex after middle cerebral artery occlusion-reperfusion (MCAO).	oxygen-glucose	306-320	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	146-149
28854438-6	2017	RESULTS: We found that MALAT1, along with the levels of conversion from autophagy-related protein microtubule-associated protein light chain 3-I (LC3-I) to LC3-phosphatidylethanolamine conjugate (LC3-II), as well as Beclin1 were up-regulated and miR-30a was down-regulated in cerebral cortex neurons after oxygen-glucose deprivation (OGD) and mouse brain cortex after middle cerebral artery occlusion-reperfusion (MCAO).	oxygen-glucose	306-320	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	156-159
28854438-6	2017	RESULTS: We found that MALAT1, along with the levels of conversion from autophagy-related protein microtubule-associated protein light chain 3-I (LC3-I) to LC3-phosphatidylethanolamine conjugate (LC3-II), as well as Beclin1 were up-regulated and miR-30a was down-regulated in cerebral cortex neurons after oxygen-glucose deprivation (OGD) and mouse brain cortex after middle cerebral artery occlusion-reperfusion (MCAO).	oxygen-glucose	306-320	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	156-159
29234386-9	2017	These results suggest that XJDH protects PC12 cells from oxygen-glucose deprivation-induced injury, which may be associated with the inhibition of the TLR4-MyD88/NF-kappaB signaling pathway.	oxygen-glucose	57-71	toll-like receptor 4	Rattus norvegicus	151-155
27665569-0	2017	Oxygen-Glucose Deprivation Induces G2/M Cell Cycle Arrest in Brain Pericytes Associated with ERK Inactivation.	oxygen-glucose	0-14	mitogen-activated protein kinase 1	Homo sapiens	93-96
27838821-0	2017	NFAT5 protects astrocytes against oxygen-glucose-serum deprivation/restoration damage via the SIRT1/Nrf2 pathway.	oxygen-glucose	34-48	nuclear factor of activated T-cells 5	Rattus norvegicus	0-5
27838821-0	2017	NFAT5 protects astrocytes against oxygen-glucose-serum deprivation/restoration damage via the SIRT1/Nrf2 pathway.	oxygen-glucose	34-48	sirtuin 1	Rattus norvegicus	94-99
27838821-0	2017	NFAT5 protects astrocytes against oxygen-glucose-serum deprivation/restoration damage via the SIRT1/Nrf2 pathway.	oxygen-glucose	34-48	NFE2 like bZIP transcription factor 2	Rattus norvegicus	100-104
27764754-0	2016	Tetrandrine protects against oxygen-glucose-serum deprivation/reoxygenation-induced injury via PI3K/AKT/NF-kappaB signaling pathway in rat spinal cord astrocytes.	oxygen-glucose	29-43	AKT serine/threonine kinase 1	Rattus norvegicus	100-103
27769861-3	2016	Here, we found that oxygen-glucose deprivation (OGD)-induced autophagy was suppressed by exogenous Act A in a concentration-dependent manner and enhanced by Act A/Smads pathway inhibitor (ActRIIA-Ab) in neuronal PC12 cells.	oxygen-glucose	20-34	inhibin subunit beta A	Rattus norvegicus	99-104
27769861-3	2016	Here, we found that oxygen-glucose deprivation (OGD)-induced autophagy was suppressed by exogenous Act A in a concentration-dependent manner and enhanced by Act A/Smads pathway inhibitor (ActRIIA-Ab) in neuronal PC12 cells.	oxygen-glucose	20-34	inhibin subunit beta A	Rattus norvegicus	157-162
27769861-3	2016	Here, we found that oxygen-glucose deprivation (OGD)-induced autophagy was suppressed by exogenous Act A in a concentration-dependent manner and enhanced by Act A/Smads pathway inhibitor (ActRIIA-Ab) in neuronal PC12 cells.	oxygen-glucose	20-34	activin A receptor type 2A	Rattus norvegicus	188-195
27838821-3	2017	In this study, our aim is to investigate whether NFAT5 overexpression can protect astrocytes against oxygen-glucose-serum deprivation/restoration (OGSD/R) damage.	oxygen-glucose	101-115	nuclear factor of activated T-cells 5	Rattus norvegicus	49-54
27966582-5	2016	The reduction of PirB expression facilitated neurite outgrowth after oxygen-glucose deprivation injury.	oxygen-glucose	69-83	leukocyte immunoglobulin like receptor B2	Rattus norvegicus	17-21
27980410-7	2016	The role of miR-455 in cell death caused by oxygen-glucose deprivation (OGD) was assessed using Cell Counting Kit-8 (CCK-8) assay.	oxygen-glucose	44-58	microRNA 455	Mus musculus	12-19
27324125-0	2016	RhoB/ROCK mediates oxygen-glucose deprivation-stimulated syncytiotrophoblast microparticle shedding in preeclampsia.	oxygen-glucose	19-33	ras homolog family member B	Homo sapiens	0-4
26515186-0	2016	Nitric Oxide Interacts with Caveolin-1 to Facilitate Autophagy-Lysosome-Mediated Claudin-5 Degradation in Oxygen-Glucose Deprivation-Treated Endothelial Cells.	oxygen-glucose	106-120	caveolin 1, caveolae protein	Mus musculus	28-38
26515186-0	2016	Nitric Oxide Interacts with Caveolin-1 to Facilitate Autophagy-Lysosome-Mediated Claudin-5 Degradation in Oxygen-Glucose Deprivation-Treated Endothelial Cells.	oxygen-glucose	106-120	claudin 5	Mus musculus	81-90
26515186-1	2016	Using in vitro oxygen-glucose deprivation (OGD) model, we have previously demonstrated that 2-h OGD induces rapid, caveolin-1-mediated dissociation of claudin-5 from the cellular cytoskeletal framework and quick endothelial barrier disruption.	oxygen-glucose	15-29	caveolin 1, caveolae protein	Mus musculus	115-125
26515186-1	2016	Using in vitro oxygen-glucose deprivation (OGD) model, we have previously demonstrated that 2-h OGD induces rapid, caveolin-1-mediated dissociation of claudin-5 from the cellular cytoskeletal framework and quick endothelial barrier disruption.	oxygen-glucose	15-29	claudin 5	Mus musculus	151-160
27693696-6	2016	And silencing of NLRP2 genes could reduce the apoptotic rate of oxygen-glucose deprivation-treated cells.	oxygen-glucose	64-78	NLR family, pyrin domain containing 2	Mus musculus	17-22
27782092-0	2016	Annexin-1 Mediates Microglial Activation and Migration via the CK2 Pathway during Oxygen-Glucose Deprivation/Reperfusion.	oxygen-glucose	82-96	annexin A1	Rattus norvegicus	0-9
27782092-0	2016	Annexin-1 Mediates Microglial Activation and Migration via the CK2 Pathway during Oxygen-Glucose Deprivation/Reperfusion.	oxygen-glucose	82-96	casein kinase 2 beta	Rattus norvegicus	63-66
27584794-0	2016	Nuclear translocation of annexin 1 following oxygen-glucose deprivation-reperfusion induces apoptosis by regulating Bid expression via p53 binding.	oxygen-glucose	45-59	annexin A1	Homo sapiens	25-34
27598143-4	2016	We found that miR-378 levels significantly decreased in N2A cells following oxygen-glucose deprivation (OGD) treatment.	oxygen-glucose	76-90	microRNA 378a	Mus musculus	14-21
27584794-0	2016	Nuclear translocation of annexin 1 following oxygen-glucose deprivation-reperfusion induces apoptosis by regulating Bid expression via p53 binding.	oxygen-glucose	45-59	BH3 interacting domain death agonist	Homo sapiens	116-119
27584794-0	2016	Nuclear translocation of annexin 1 following oxygen-glucose deprivation-reperfusion induces apoptosis by regulating Bid expression via p53 binding.	oxygen-glucose	45-59	tumor protein p53	Homo sapiens	135-138
27584794-3	2016	Here we report that importazole (IPZ), an importin beta (Impbeta)-specific inhibitor, decreased ANXA1 nuclear accumulation and reduced the rate of neuronal death induced by nuclear ANXA1 migration after oxygen-glucose deprivation-reoxygenation (OGD/R).	oxygen-glucose	203-217	annexin A1	Homo sapiens	181-186
27132231-3	2016	The results indicate that GS24-NFkappaB was successfully delivered into a murine brain-derived endothelial cell line, bEND5, and inhibited inflammatory responses induced by tumor necrosis factor alpha (TNF-alpha) or oxygen-glucose deprivation/re-oxygenation (OGD/R) via down-regulation of the nuclear NF-kappaB subunit, p65, as well as its downstream inflammatory cytokines, inter-cellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule (VCAM-1).	oxygen-glucose	216-230	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	31-39
26887441-3	2016	We found that up-regulation of miR-150 increased permeability of BBB as detected by MRI after permanent middle cerebral artery occlusion in vivo as well as increased permeability of brain microvascular endothelial cells after oxygen-glucose deprivation in vitro.	oxygen-glucose	226-240	microRNA 150	Rattus norvegicus	31-38
27651777-6	2016	These findings confirm that miR-27a protects hippocampal neurons against oxygen-glucose deprivation-induced injuries.	oxygen-glucose	73-87	microRNA 27a	Homo sapiens	28-35
27435822-7	2016	PKCepsilon-mediated decreases in cell death following oxygen-glucose deprivation were abolished in cortical cultures harvested from SIRT5-/- mice.	oxygen-glucose	54-68	protein kinase C, epsilon	Mus musculus	0-10
27435822-7	2016	PKCepsilon-mediated decreases in cell death following oxygen-glucose deprivation were abolished in cortical cultures harvested from SIRT5-/- mice.	oxygen-glucose	54-68	sirtuin 5	Mus musculus	132-137
27255374-4	2016	An oxygen-glucose deprivation and reoxygenation (OGD/R) model in vitro and a middle cerebral artery occlusion (MCAO) model in vivo were used in this paper, and the results showned that SAB remarkably increased the viabilities of PC12 cells and primary cortical neurons after OGD/R injury and notably prevented cerebral ischemia/reperfusion (I/R) injury.	oxygen-glucose	3-17	SH3-domain binding protein 5	Rattus norvegicus	185-188
27179807-0	2016	Impact of Heat Shock Protein A 12B Overexpression on Spinal Astrocyte Survival Against Oxygen-Glucose-Serum Deprivation/Restoration in Primary Cultured Astrocytes.	oxygen-glucose	87-101	heat shock protein family A (Hsp70) member 12B	Homo sapiens	10-34
27179807-3	2016	The aim of this study is to investigate whether HSPA12B overexpression can protect astrocytes from oxygen-glucose-serum deprivation/restoration (OGD/R) injury.	oxygen-glucose	99-113	heat shock protein family A (Hsp70) member 12B	Homo sapiens	48-55
26093381-5	2016	Gephyrin cleavage was also observed in cultured hippocampal neurons subjected to transient oxygen-glucose deprivation (OGD), an in vitro model of brain ischemia, and after transient middle cerebral artery occlusion (MCAO) in mice, a model of focal brain ischemia.	oxygen-glucose	91-105	gephyrin	Mus musculus	0-8
27456198-0	2016	IL-10 Promotes Neurite Outgrowth and Synapse Formation in Cultured Cortical Neurons after the Oxygen-Glucose Deprivation via JAK1/STAT3 Pathway.	oxygen-glucose	94-108	interleukin 10	Rattus norvegicus	0-5
27113328-0	2016	GPER1 mediates estrogen-induced neuroprotection against oxygen-glucose deprivation in the primary hippocampal neurons.	oxygen-glucose	56-70	G protein-coupled estrogen receptor 1	Homo sapiens	0-5
27113328-3	2016	Here our studies on primary hippocampal neurons have focused on GPER1 in an in vitro model of ischemia using oxygen-glucose deprivation (OGD).	oxygen-glucose	109-123	G protein-coupled estrogen receptor 1	Homo sapiens	64-69
27288786-6	2016	Furthermore, CaSR expression was upregulated in rat primary cortical astrocytes exposed to oxygen-glucose deprivation, which undergo reactive gliosis-like changes.	oxygen-glucose	91-105	calcium-sensing receptor	Rattus norvegicus	13-17
26887441-5	2016	We found in brain microvascular endothelial cells that overexpression of miR-150 decreased not only cell survival rate but also the expression levels of claudin-5 after oxygen-glucose deprivation.	oxygen-glucose	169-183	microRNA 150	Rattus norvegicus	73-80
26887441-5	2016	We found in brain microvascular endothelial cells that overexpression of miR-150 decreased not only cell survival rate but also the expression levels of claudin-5 after oxygen-glucose deprivation.	oxygen-glucose	169-183	claudin 5	Rattus norvegicus	153-162
26414218-0	2016	2-Arachidonylglycerol Protects Primary Astrocytes Exposed to Oxygen-Glucose Deprivation Through a Blockade of NDRG2 Signaling and STAT3 Phosphorylation.	oxygen-glucose	61-75	NDRG family member 2	Homo sapiens	110-115
26414218-0	2016	2-Arachidonylglycerol Protects Primary Astrocytes Exposed to Oxygen-Glucose Deprivation Through a Blockade of NDRG2 Signaling and STAT3 Phosphorylation.	oxygen-glucose	61-75	signal transducer and activator of transcription 3	Homo sapiens	130-135
26915982-0	2016	YiQiFuMai Powder Injection ameliorates the oxygen-glucose deprivation-induced brain microvascular endothelial barrier dysfunction associated with the NF-kappaB and ROCK1/MLC signaling pathways.	oxygen-glucose	43-57	megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)	Mus musculus	170-173
27230112-6	2016	RESULTS: We provided the first evidence that glycine increased the expression of microRNA-301a in cultured rat cortical neurons and protected against cortical neuronal death through up-regulation of microRNA-301a after oxygen-glucose deprivation.	oxygen-glucose	219-233	microRNA 301a	Rattus norvegicus	199-212
27230112-8	2016	We revealed that PTEN down-regulation by microRNA-301a mediated glycine-induced neuroprotective effect following oxygen-glucose deprivation.	oxygen-glucose	113-127	phosphatase and tensin homolog	Rattus norvegicus	17-21
27230112-8	2016	We revealed that PTEN down-regulation by microRNA-301a mediated glycine-induced neuroprotective effect following oxygen-glucose deprivation.	oxygen-glucose	113-127	microRNA 301a	Rattus norvegicus	41-54
27230112-9	2016	CONCLUSIONS: Our results suggest that 1) microRNA-301a is neuroprotective in oxygen-glucose deprivation-induced neuronal injury; 2) glycine is an upstream regulator of microRNA-301a; 3) glycine confers neuroprotection through microRNA-301a/PTEN signal pathway.	oxygen-glucose	77-91	microRNA 301a	Rattus norvegicus	41-54
27230112-9	2016	CONCLUSIONS: Our results suggest that 1) microRNA-301a is neuroprotective in oxygen-glucose deprivation-induced neuronal injury; 2) glycine is an upstream regulator of microRNA-301a; 3) glycine confers neuroprotection through microRNA-301a/PTEN signal pathway.	oxygen-glucose	77-91	phosphatase and tensin homolog	Rattus norvegicus	240-244
26915982-0	2016	YiQiFuMai Powder Injection ameliorates the oxygen-glucose deprivation-induced brain microvascular endothelial barrier dysfunction associated with the NF-kappaB and ROCK1/MLC signaling pathways.	oxygen-glucose	43-57	Rho-associated coiled-coil containing protein kinase 1	Mus musculus	164-169
27076094-7	2016	Over-expression of Hsp90aa1 could attenuate oxygen-glucose deprivation (OGD)-induced apoptosis of NRVCs.	oxygen-glucose	44-58	heat shock protein 90 alpha family class A member 1	Rattus norvegicus	19-27
27478098-3	2016	The present study was designed to investigate the regulation of NOD2 (Nucleotide-binding oligomerization domain-containing protein 2) by brazilein for its protection of neuron in cerebral ischemia in vivo and oxygen-glucose deprivation in vitro.	oxygen-glucose	209-223	nucleotide-binding oligomerization domain containing 2	Mus musculus	64-68
27478098-3	2016	The present study was designed to investigate the regulation of NOD2 (Nucleotide-binding oligomerization domain-containing protein 2) by brazilein for its protection of neuron in cerebral ischemia in vivo and oxygen-glucose deprivation in vitro.	oxygen-glucose	209-223	nucleotide-binding oligomerization domain containing 2	Mus musculus	70-132
26721511-8	2016	Moreover, increased activity of Act A signal loop could promote PC12 cell proliferation and enhance the survival rate of cells to Oxygen-Glucose Deprivation.	oxygen-glucose	130-144	inhibin subunit beta A	Rattus norvegicus	32-37
27067428-9	2016	Furthermore, HSYA reduced the magnitude of NMDAR-mediated membrane depolarization currents evoked by oxygen-glucose deprivation, and suppressed oxygen-glucose deprivation-induced and NMDAR-dependent ischemic long-term potentiation, which is believed to cause severe reperfusion damage after ischemia.	oxygen-glucose	101-115	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	43-48
26690896-3	2016	Here we reported that astrocyte geranylgeranyltransferase I (GGTI)-mediated Rac1 activation up-regulated NF-kappaB expression and promoted the neuronal apoptosis after oxygen-glucose deprivation followed by oxygen-glucose regeneration (OGD/R).	oxygen-glucose	168-182	Rac family small GTPase 1	Rattus norvegicus	76-80
26966066-1	2016	Pigment epithelial-derived factor (PEDF) is a glycoprotein with broad biological activities including inhibiting oxygen-glucose deprivation(OGD)-induced cardiomyocytes apoptosis through its anti-oxidative properties.	oxygen-glucose	113-127	serpin family F member 1	Rattus norvegicus	0-33
26966066-1	2016	Pigment epithelial-derived factor (PEDF) is a glycoprotein with broad biological activities including inhibiting oxygen-glucose deprivation(OGD)-induced cardiomyocytes apoptosis through its anti-oxidative properties.	oxygen-glucose	113-127	serpin family F member 1	Rattus norvegicus	35-39
26690896-3	2016	Here we reported that astrocyte geranylgeranyltransferase I (GGTI)-mediated Rac1 activation up-regulated NF-kappaB expression and promoted the neuronal apoptosis after oxygen-glucose deprivation followed by oxygen-glucose regeneration (OGD/R).	oxygen-glucose	207-221	Rac family small GTPase 1	Rattus norvegicus	76-80
26746802-8	2016	Moreover, HO-1 knockdown attenuated the protective effect of andrographolide against oxygen-glucose deprivation-induced CEC death.	oxygen-glucose	85-99	heme oxygenase 1	Rattus norvegicus	10-14
27031970-5	2016	The expression patterns of C2dat1 and CAMK2D were confirmed in mouse Neuro-2a cells in response to in vitro ischemia (oxygen-glucose deprivation/reoxygenation, OGD/R).	oxygen-glucose	118-132	CAMK2D associated transcript 1	Mus musculus	27-33
27031970-5	2016	The expression patterns of C2dat1 and CAMK2D were confirmed in mouse Neuro-2a cells in response to in vitro ischemia (oxygen-glucose deprivation/reoxygenation, OGD/R).	oxygen-glucose	118-132	calcium/calmodulin-dependent protein kinase II, delta	Mus musculus	38-44
26950456-0	2016	Effects of c-Jun N-terminal kinase on Activin A/Smads signaling in PC12 cell suffered from oxygen-glucose deprivation.	oxygen-glucose	91-105	mitogen-activated protein kinase 8	Rattus norvegicus	11-34
26760196-2	2016	We have reported the neuroprotective properties of H2S against oxygen-glucose deprivation/reoxygenation (OGD/R)-induced injury by inhibiting the phosphorylation of p38.	oxygen-glucose	63-77	mitogen activated protein kinase 14	Rattus norvegicus	164-167
26950456-0	2016	Effects of c-Jun N-terminal kinase on Activin A/Smads signaling in PC12 cell suffered from oxygen-glucose deprivation.	oxygen-glucose	91-105	inhibin subunit beta A	Rattus norvegicus	38-47
26562519-8	2016	Diffuse cytoplasmic cathepsin-B and LAMP-1 immunostaining synchronized with the pyknotic nuclear changes 2 days post reperfusion, and a rise of lysosomal pH with the leakage of DND-153, a dye of lysosomes, after oxygen-glucose deprivation (OGD) was detected.	oxygen-glucose	212-226	cathepsin B	Rattus norvegicus	20-31
26918757-0	2016	MLIF Alleviates SH-SY5Y Neuroblastoma Injury Induced by Oxygen-Glucose Deprivation by Targeting Eukaryotic Translation Elongation Factor 1A2.	oxygen-glucose	56-70	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	96-140
26869884-0	2016	BID Mediates Oxygen-Glucose Deprivation-Induced Neuronal Injury in Organotypic Hippocampal Slice Cultures and Modulates Tissue Inflammation in a Transient Focal Cerebral Ischemia Model without Changing Lesion Volume.	oxygen-glucose	13-27	BH3 interacting domain death agonist	Mus musculus	0-3
26603372-7	2016	Consistent with the in vivo findings, oxygen-glucose deprivation (OGD) significantly reduced TLR3 and IL-6 mRNA expression in microglia, but poly-ICLC significantly rescued TLR3 and IL-6 expression.	oxygen-glucose	38-52	toll like receptor 3	Homo sapiens	93-97
26603372-7	2016	Consistent with the in vivo findings, oxygen-glucose deprivation (OGD) significantly reduced TLR3 and IL-6 mRNA expression in microglia, but poly-ICLC significantly rescued TLR3 and IL-6 expression.	oxygen-glucose	38-52	interleukin 6	Homo sapiens	102-106
26603372-13	2016	Also, oxygen-glucose deprivation (OGD) reduces TLR3 and IL-6 expression in microglia, but polyinosinic polycytidylic acid (poly-ICLC) rescues TLR3 and IL-6.	oxygen-glucose	6-20	toll like receptor 3	Homo sapiens	47-51
26603372-13	2016	Also, oxygen-glucose deprivation (OGD) reduces TLR3 and IL-6 expression in microglia, but polyinosinic polycytidylic acid (poly-ICLC) rescues TLR3 and IL-6.	oxygen-glucose	6-20	interleukin 6	Homo sapiens	56-60
26562519-8	2016	Diffuse cytoplasmic cathepsin-B and LAMP-1 immunostaining synchronized with the pyknotic nuclear changes 2 days post reperfusion, and a rise of lysosomal pH with the leakage of DND-153, a dye of lysosomes, after oxygen-glucose deprivation (OGD) was detected.	oxygen-glucose	212-226	lysosomal-associated membrane protein 1	Rattus norvegicus	36-42
27035834-0	2016	Neuroserpin Protects Rat Neurons and Microglia-Mediated Inflammatory Response Against Oxygen-Glucose Deprivation- and Reoxygenation Treatments in an In Vitro Study.	oxygen-glucose	86-100	serpin family I member 1	Rattus norvegicus	0-11
26938208-0	2016	Oxygen-Glucose-Deprivation/Reoxygenation-Induced Autophagic Cell Death Depends on JNK-Mediated Phosphorylation of Bcl-2.	oxygen-glucose	0-14	mitogen-activated protein kinase 8	Rattus norvegicus	82-85
27035834-3	2016	In the present study, we further observe the effects of NSP on neurons and microglia-mediated inflammatory response following oxygen-glucose deprivation (OGD), and explore possible mechanisms related to neuroprotection of OGD in the central nervous system (CNS).	oxygen-glucose	126-140	serpin family I member 1	Rattus norvegicus	56-59
26498254-0	2015	PFKFB3-mediated glycolysis is involved in reactive astrocyte proliferation after oxygen-glucose deprivation/reperfusion and is regulated by Cdh1.	oxygen-glucose	81-95	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Rattus norvegicus	0-6
26938208-0	2016	Oxygen-Glucose-Deprivation/Reoxygenation-Induced Autophagic Cell Death Depends on JNK-Mediated Phosphorylation of Bcl-2.	oxygen-glucose	0-14	BCL2, apoptosis regulator	Rattus norvegicus	114-119
26385023-0	2016	Oxygen-glucose deprivation preconditioning protects neurons against oxygen-glucose deprivation/reperfusion induced injury via bone morphogenetic protein-7 mediated ERK, p38 and Smad signalling pathways.	oxygen-glucose	0-14	bone morphogenetic protein 7	Homo sapiens	126-154
26385023-0	2016	Oxygen-glucose deprivation preconditioning protects neurons against oxygen-glucose deprivation/reperfusion induced injury via bone morphogenetic protein-7 mediated ERK, p38 and Smad signalling pathways.	oxygen-glucose	0-14	mitogen-activated protein kinase 14	Homo sapiens	169-172
26385023-0	2016	Oxygen-glucose deprivation preconditioning protects neurons against oxygen-glucose deprivation/reperfusion induced injury via bone morphogenetic protein-7 mediated ERK, p38 and Smad signalling pathways.	oxygen-glucose	0-14	SMAD family member 1	Homo sapiens	177-181
26385023-0	2016	Oxygen-glucose deprivation preconditioning protects neurons against oxygen-glucose deprivation/reperfusion induced injury via bone morphogenetic protein-7 mediated ERK, p38 and Smad signalling pathways.	oxygen-glucose	68-82	bone morphogenetic protein 7	Homo sapiens	126-154
26385023-0	2016	Oxygen-glucose deprivation preconditioning protects neurons against oxygen-glucose deprivation/reperfusion induced injury via bone morphogenetic protein-7 mediated ERK, p38 and Smad signalling pathways.	oxygen-glucose	68-82	mitogen-activated protein kinase 14	Homo sapiens	169-172
26385023-0	2016	Oxygen-glucose deprivation preconditioning protects neurons against oxygen-glucose deprivation/reperfusion induced injury via bone morphogenetic protein-7 mediated ERK, p38 and Smad signalling pathways.	oxygen-glucose	68-82	SMAD family member 1	Homo sapiens	177-181
26385023-2	2016	In this study, primary cortical neurons and the SH-SY5Y cell line were used to investigate the role of BMP-7 and its downstream signals in the neuroprotective effects of oxygen-glucose deprivation preconditioning (OGDPC).	oxygen-glucose	170-184	bone morphogenetic protein 7	Homo sapiens	103-108
26698301-0	2015	Huwe1 interacts with Gadd45b under oxygen-glucose deprivation and reperfusion injury in primary Rat cortical neuronal cells.	oxygen-glucose	35-49	HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1	Rattus norvegicus	0-5
26698301-0	2015	Huwe1 interacts with Gadd45b under oxygen-glucose deprivation and reperfusion injury in primary Rat cortical neuronal cells.	oxygen-glucose	35-49	growth arrest and DNA-damage-inducible, beta	Rattus norvegicus	21-28
26698301-4	2015	Here, using an oxygen-glucose deprivation and reperfusion (OGD/R) model, we identified Huwe1/Mule/ARF-BP1, a HECT domain containing ubiquitin ligase, involved in the control of Gadd45b protein level.	oxygen-glucose	15-29	HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1	Rattus norvegicus	87-92
26698301-4	2015	Here, using an oxygen-glucose deprivation and reperfusion (OGD/R) model, we identified Huwe1/Mule/ARF-BP1, a HECT domain containing ubiquitin ligase, involved in the control of Gadd45b protein level.	oxygen-glucose	15-29	growth arrest and DNA-damage-inducible, beta	Rattus norvegicus	177-184
26658636-9	2015	Furthermore, MT-II also improved survival of the mice after MCAO, suppressed TNF-alpha mRNA induction in ischemic brain tissue, and protected primary neuronal cells against oxygen-glucose-deprivation in vitro.	oxygen-glucose	173-187	metallothionein 2	Mus musculus	13-18
26174325-7	2015	STAT6 siRNA efficiently prevented the increase of 12/15-LOX in murine primary neurons, both after induction of oxidative stress and after oxygen-glucose deprivation.	oxygen-glucose	138-152	signal transducer and activator of transcription 6	Mus musculus	0-5
26174325-7	2015	STAT6 siRNA efficiently prevented the increase of 12/15-LOX in murine primary neurons, both after induction of oxidative stress and after oxygen-glucose deprivation.	oxygen-glucose	138-152	arachidonate 15-lipoxygenase	Mus musculus	50-59
26884981-0	2015	Role of microRNA-134 in the neuroprotective effects of propofol against oxygen-glucose deprivation and related mechanisms.	oxygen-glucose	72-86	microRNA 134	Homo sapiens	8-20
26449616-4	2015	First, in vitro experiments confirmed the vascular origin and changes in miR-126 in brain endothelial cultures subjected to oxygen-glucose deprivation.	oxygen-glucose	124-138	microRNA 126b	Rattus norvegicus	73-80
26076738-5	2015	Conversely, siRNA-mediated depletion of IGFBP-2 inhibited oxygen-glucose deprivation (OGD)-induced EPC-endothelial adhesion.	oxygen-glucose	58-72	insulin like growth factor binding protein 2	Homo sapiens	40-47
26454173-0	2015	PERK pathway is involved in oxygen-glucose-serum deprivation-induced NF-kB activation via ROS generation in spinal cord astrocytes.	oxygen-glucose	28-42	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	0-4
26036941-6	2015	Using an in vitro oxygen-glucose deprivation model, we show that the HCA1 receptor agonist 3,5-dihydroxybenzoic acid reduces cell death.	oxygen-glucose	18-32	HCA1	Homo sapiens	69-73
26232180-0	2015	NR2B-dependent cyclophilin D translocation suppresses the recovery of synaptic transmission after oxygen-glucose deprivation.	oxygen-glucose	98-112	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	0-4
26232180-0	2015	NR2B-dependent cyclophilin D translocation suppresses the recovery of synaptic transmission after oxygen-glucose deprivation.	oxygen-glucose	98-112	peptidylprolyl isomerase F (cyclophilin F)	Mus musculus	15-28
26232180-3	2015	Using an ex vivo ischemia model of oxygen-glucose deprivation (OGD) in hippocampal slices, we identified a NR2B-dependent mechanism for CypD translocation onto the mitochondrial inner membrane.	oxygen-glucose	35-49	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	107-111
26232180-3	2015	Using an ex vivo ischemia model of oxygen-glucose deprivation (OGD) in hippocampal slices, we identified a NR2B-dependent mechanism for CypD translocation onto the mitochondrial inner membrane.	oxygen-glucose	35-49	peptidylprolyl isomerase F (cyclophilin F)	Mus musculus	136-140
26308910-0	2015	Activation of SphK1 by K6PC-5 Inhibits Oxygen-Glucose Deprivation/Reoxygenation-Induced Myocardial Cell Death.	oxygen-glucose	39-53	sphingosine kinase 1	Rattus norvegicus	14-19
26308910-1	2015	In the current study, we evaluated the potential effect of a novel sphingosine kinase 1 (SphK1) activator, K6PC-5, on oxygen-glucose deprivation (OGD)/reoxygenation-induced damages to myocardial cells.	oxygen-glucose	118-132	sphingosine kinase 1	Rattus norvegicus	67-87
26308910-1	2015	In the current study, we evaluated the potential effect of a novel sphingosine kinase 1 (SphK1) activator, K6PC-5, on oxygen-glucose deprivation (OGD)/reoxygenation-induced damages to myocardial cells.	oxygen-glucose	118-132	sphingosine kinase 1	Rattus norvegicus	89-94
25576184-0	2015	Neuroprotective effects of the allosteric agonist of metabotropic glutamate receptor 7 AMN082 on oxygen-glucose deprivation- and kainate-induced neuronal cell death.	oxygen-glucose	97-111	glutamate metabotropic receptor 7	Homo sapiens	53-86
26079709-3	2015	MMP-3 was produced and secreted in bEnd.3 cells, a mouse brain-derived endothelial cell line, by oxygen-glucose deprivation/reoxygenation (OGD/RO).	oxygen-glucose	97-111	matrix metallopeptidase 3	Mus musculus	0-5
26302161-5	2015	We showed that p53 is activated in ischemic brains and in oxygen-glucose deprivation (OGD)-induced cell death in neurons and astrocytes.	oxygen-glucose	58-72	tumor protein p53	Homo sapiens	15-18
26604904-5	2015	These results confirm that oxygen-glucose deprivation down-regulates BACE1 expression in Neuro-2a/APP695 cells through the introduction of autophagy.	oxygen-glucose	27-41	beta-site APP cleaving enzyme 1	Mus musculus	69-74
25976407-0	2015	Inhibiting histone deacetylase 6 partly protects cultured rat cortical neurons from oxygen-glucose deprivation-induced necroptosis.	oxygen-glucose	84-98	histone deacetylase 6	Rattus norvegicus	11-32
26604904-0	2015	Oxygen-glucose deprivation regulates BACE1 expression through induction of autophagy in Neuro-2a/APP695 cells.	oxygen-glucose	0-14	beta-site APP cleaving enzyme 1	Mus musculus	37-42
26604904-4	2015	Either oxygen-glucose deprivation or Rapamycin down-regulated the expression of BACE1 while 3-methyladenine up-regulated BACE1 expression.	oxygen-glucose	7-21	beta-site APP cleaving enzyme 1	Mus musculus	80-85
26270349-7	2015	Our data clearly indicate that GADD45beta-I significantly reduces neuronal death in excitotoxicity induced by either N-methyl-D-aspartate exposure or by oxygen-glucose deprivation in vitro.	oxygen-glucose	153-167	growth arrest and DNA damage inducible beta	Homo sapiens	31-41
26550264-0	2015	Decorin protects human hepatoma HepG2 cells against oxygen-glucose deprivation via modulating autophagy.	oxygen-glucose	52-66	decorin	Homo sapiens	0-7
25929187-0	2015	S-Nitrosylation of proline-rich tyrosine kinase 2 involves its activation induced by oxygen-glucose deprivation.	oxygen-glucose	85-99	protein tyrosine kinase 2 beta	Homo sapiens	19-49
25708150-4	2015	The present study provides a systematic investigation of the influence of experimental ischemia, induced by oxygen-glucose-deprivation, on the FAK- and PYK2-mediated signalling in organotypic hippocampal slice cultures.	oxygen-glucose	108-122	protein tyrosine kinase 2	Homo sapiens	143-146
25023896-0	2015	TAT-mediated delivery of neuroglobin attenuates apoptosis induced by oxygen-glucose deprivation via the Jak2/Stat3 pathway in vitro.	oxygen-glucose	69-83	neuroglobin	Rattus norvegicus	25-36
25023896-3	2015	The aim of this study is to investigate the role of TAT-Ngb in attenuating oxygen-glucose deprivation (OGD) induced apoptosis and to explore the possible mechanism.	oxygen-glucose	75-89	neuroglobin	Rattus norvegicus	56-59
25929187-6	2015	Moreover, our results showed that S-nitrosylation and phosphorylation of PYK2 over-expressed in SH-SY5Y cells was significantly increased after oxygen-glucose deprivation (OGD).	oxygen-glucose	144-158	protein tyrosine kinase 2 beta	Homo sapiens	73-77
25841561-3	2015	In this study, the role of NMNAT1 in oxygen-glucose deprivation (OGD)-induced primary cultured neuronal cell injury and mouse middle cerebral artery occlusion-induced cerebral ischemic injury and its regulation on AMP-activated protein kinase (AMPK) activation were evaluated.	oxygen-glucose	37-51	nicotinamide nucleotide adenylyltransferase 1	Mus musculus	27-33
25708150-4	2015	The present study provides a systematic investigation of the influence of experimental ischemia, induced by oxygen-glucose-deprivation, on the FAK- and PYK2-mediated signalling in organotypic hippocampal slice cultures.	oxygen-glucose	108-122	protein tyrosine kinase 2 beta	Homo sapiens	152-156
25407820-0	2015	Sulfiredoxin-1 attenuates oxidative stress via Nrf2/ARE pathway and 2-Cys Prdxs after oxygen-glucose deprivation in astrocytes.	oxygen-glucose	86-100	sulfiredoxin 1	Homo sapiens	0-14
25605289-5	2015	Oxygen-glucose deprivation in cortical organotypic cultures caused neuronal death that was reduced with P2X7 and pannexin-1 blockers as well as in organotypic cultures derived from mice lacking P2X7 and pannexin 1.	oxygen-glucose	0-14	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	104-108
25605289-5	2015	Oxygen-glucose deprivation in cortical organotypic cultures caused neuronal death that was reduced with P2X7 and pannexin-1 blockers as well as in organotypic cultures derived from mice lacking P2X7 and pannexin 1.	oxygen-glucose	0-14	pannexin 1	Mus musculus	113-123
25605289-5	2015	Oxygen-glucose deprivation in cortical organotypic cultures caused neuronal death that was reduced with P2X7 and pannexin-1 blockers as well as in organotypic cultures derived from mice lacking P2X7 and pannexin 1.	oxygen-glucose	0-14	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	194-198
25605289-5	2015	Oxygen-glucose deprivation in cortical organotypic cultures caused neuronal death that was reduced with P2X7 and pannexin-1 blockers as well as in organotypic cultures derived from mice lacking P2X7 and pannexin 1.	oxygen-glucose	0-14	pannexin 1	Mus musculus	203-213
25755278-5	2015	In contrast, GAP43(S41D), but not GAP43(S41A), inhibited the physiological aggregation/clustering of gephyrin, reduced surface GABA(A)Rs under physiological conditions, and attenuated gephyrin misfolding under transient oxygen-glucose deprivation (tOGD) that mimics pathological neonatal hypoxia.	oxygen-glucose	220-234	growth associated protein 43	Homo sapiens	13-18
26173295-2	2015	This study modified ADSCs with the Bcl-2 gene in order to increase the secretion of growth factors during oxygen-glucose deprivation (OGD).	oxygen-glucose	106-120	BCL2 apoptosis regulator	Homo sapiens	35-40
25543031-0	2015	Oxygen-glucose deprivation inducing B1 RNA inhibits neuronal cells metabolic activity by NLRP3 and associated proinflammatory cytokines production.	oxygen-glucose	0-14	NLR family, pyrin domain containing 3	Mus musculus	89-94
24939696-2	2015	Previous studies have indicated that oxygen-glucose deprivation/reoxygenation (OGD/R) induces neuronal apoptosis via TRPM7.	oxygen-glucose	37-51	transient receptor potential cation channel, subfamily M, member 7	Rattus norvegicus	117-122
25712659-0	2015	The cyclic AMP effects and neuroprotective activities of PACAP and VIP in cultured astrocytes and neurons exposed to oxygen-glucose deprivation.	oxygen-glucose	117-131	adenylate cyclase activating polypeptide 1	Rattus norvegicus	57-62
25712659-0	2015	The cyclic AMP effects and neuroprotective activities of PACAP and VIP in cultured astrocytes and neurons exposed to oxygen-glucose deprivation.	oxygen-glucose	117-131	vasoactive intestinal peptide	Rattus norvegicus	67-70
25712659-4	2015	The aim of this study was to evaluate the effect of oxygen-glucose deprivation (OGD) - an established in vitro model for ischemic cell stress - on PACAP and VIP-evoked receptor-mediated cAMP generation in glial and neuronal cells, and to determine whether PACAP and VIP have neuroprotective activity under these conditions.	oxygen-glucose	52-66	adenylate cyclase activating polypeptide 1	Rattus norvegicus	147-152
25712659-4	2015	The aim of this study was to evaluate the effect of oxygen-glucose deprivation (OGD) - an established in vitro model for ischemic cell stress - on PACAP and VIP-evoked receptor-mediated cAMP generation in glial and neuronal cells, and to determine whether PACAP and VIP have neuroprotective activity under these conditions.	oxygen-glucose	52-66	vasoactive intestinal peptide	Rattus norvegicus	157-160
25712659-4	2015	The aim of this study was to evaluate the effect of oxygen-glucose deprivation (OGD) - an established in vitro model for ischemic cell stress - on PACAP and VIP-evoked receptor-mediated cAMP generation in glial and neuronal cells, and to determine whether PACAP and VIP have neuroprotective activity under these conditions.	oxygen-glucose	52-66	adenylate cyclase activating polypeptide 1	Rattus norvegicus	256-261
25712659-4	2015	The aim of this study was to evaluate the effect of oxygen-glucose deprivation (OGD) - an established in vitro model for ischemic cell stress - on PACAP and VIP-evoked receptor-mediated cAMP generation in glial and neuronal cells, and to determine whether PACAP and VIP have neuroprotective activity under these conditions.	oxygen-glucose	52-66	vasoactive intestinal peptide	Rattus norvegicus	266-269
25684245-5	2015	Within the miRNAs whose expression was significantly down-regulated, we identified one miRNA (miR182) that targeted the 3"-untranslated region (3"-UTR) of Clock, a key component of clock genes, and played a crucial role in regulating CLOCK expression after oxygen-glucose deprivation in primarily cultured pinealocytes.	oxygen-glucose	257-271	microRNA 182	Rattus norvegicus	94-100
25684245-5	2015	Within the miRNAs whose expression was significantly down-regulated, we identified one miRNA (miR182) that targeted the 3"-untranslated region (3"-UTR) of Clock, a key component of clock genes, and played a crucial role in regulating CLOCK expression after oxygen-glucose deprivation in primarily cultured pinealocytes.	oxygen-glucose	257-271	clock circadian regulator	Rattus norvegicus	155-160
25684245-5	2015	Within the miRNAs whose expression was significantly down-regulated, we identified one miRNA (miR182) that targeted the 3"-untranslated region (3"-UTR) of Clock, a key component of clock genes, and played a crucial role in regulating CLOCK expression after oxygen-glucose deprivation in primarily cultured pinealocytes.	oxygen-glucose	257-271	clock circadian regulator	Rattus norvegicus	181-186
25684245-5	2015	Within the miRNAs whose expression was significantly down-regulated, we identified one miRNA (miR182) that targeted the 3"-untranslated region (3"-UTR) of Clock, a key component of clock genes, and played a crucial role in regulating CLOCK expression after oxygen-glucose deprivation in primarily cultured pinealocytes.	oxygen-glucose	257-271	clock circadian regulator	Rattus norvegicus	234-239
25878600-5	2015	These findings suggest that curcumin activates the expression of thioredoxin, an antioxidant protein in the Nrf2 pathway, and protects neurons from death caused by oxygen-glucose deprivation in an in vitro model of ischemia/reperfusion.	oxygen-glucose	164-178	thioredoxin 1	Rattus norvegicus	65-76
25657114-1	2015	Protosappanin B (PTB) is a bioactive dibenzoxocin derivative isolated from Caesalpinia sappan L. Here, we investigated the neuroprotective effects and the potential mechanisms of PTB on oxygen-glucose deprivation (OGD)-injured PC12 cells.	oxygen-glucose	186-200	polypyrimidine tract binding protein 1	Rattus norvegicus	0-15
25657114-1	2015	Protosappanin B (PTB) is a bioactive dibenzoxocin derivative isolated from Caesalpinia sappan L. Here, we investigated the neuroprotective effects and the potential mechanisms of PTB on oxygen-glucose deprivation (OGD)-injured PC12 cells.	oxygen-glucose	186-200	polypyrimidine tract binding protein 1	Rattus norvegicus	179-182
24826917-6	2015	MIF has a protective effect on cortical neurons under oxygen-glucose deprivation (OGD) treatment.	oxygen-glucose	54-68	macrophage migration inhibitory factor	Homo sapiens	0-3
25446127-3	2015	Here, we investigated the potential effect of FGF10, a member of FGFs, on neuron survival in oxygen-glucose deprivation (OGD) model.	oxygen-glucose	93-107	fibroblast growth factor 10	Mus musculus	46-51
25871875-0	2015	Sonic hedgehog signaling mediates resveratrol to increase proliferation of neural stem cells after oxygen-glucose deprivation/reoxygenation injury in vitro.	oxygen-glucose	99-113	sonic hedgehog signaling molecule	Rattus norvegicus	0-14
25395029-2	2015	The influence of 12/15-lipoxygenase (12/15-LOX) on the activity of PPARgamma in oxygen-glucose deprivation (OGD) and ischemia-reperfusion (I/R) was investigated.	oxygen-glucose	80-94	arachidonate 15-lipoxygenase	Rattus norvegicus	17-35
26693244-0	2015	Synergistic Use of Geniposide and Ginsenoside Rg1 Balance Microglial TNF-alpha and TGF-beta1 following Oxygen-Glucose Deprivation In Vitro: A Genome-Wide Survey.	oxygen-glucose	103-117	protein phosphatase 1, regulatory subunit 3A	Mus musculus	46-49
25395029-2	2015	The influence of 12/15-lipoxygenase (12/15-LOX) on the activity of PPARgamma in oxygen-glucose deprivation (OGD) and ischemia-reperfusion (I/R) was investigated.	oxygen-glucose	80-94	arachidonate 15-lipoxygenase	Rattus norvegicus	37-46
25395029-2	2015	The influence of 12/15-lipoxygenase (12/15-LOX) on the activity of PPARgamma in oxygen-glucose deprivation (OGD) and ischemia-reperfusion (I/R) was investigated.	oxygen-glucose	80-94	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	67-76
24975470-0	2014	Curcumin protects neurons against oxygen-glucose deprivation/reoxygenation-induced injury through activation of peroxisome proliferator-activated receptor-gamma function.	oxygen-glucose	34-48	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	112-160
25281791-3	2015	In this study, we demonstrated that human ASC-CM potently blockeds caspase-3 mediated cortical neuronal apoptosis under in vitro oxygen-glucose deprivation (OGD).	oxygen-glucose	129-143	caspase 3	Homo sapiens	67-76
26199678-0	2015	Hsp20 Protects against Oxygen-Glucose Deprivation/Reperfusion-Induced Golgi Fragmentation and Apoptosis through Fas/FasL Pathway.	oxygen-glucose	23-37	heat shock protein, alpha-crystallin-related, B6	Mus musculus	0-5
26199678-0	2015	Hsp20 Protects against Oxygen-Glucose Deprivation/Reperfusion-Induced Golgi Fragmentation and Apoptosis through Fas/FasL Pathway.	oxygen-glucose	23-37	Fas ligand (TNF superfamily, member 6)	Mus musculus	116-120
25005877-7	2014	First, NAMPT was secreted into the extracellular medium by primary cortical neurons exposed to ischemia-like oxygen-glucose deprivation (OGD) in vitro.	oxygen-glucose	109-123	nicotinamide phosphoribosyltransferase	Mus musculus	7-12
25128463-0	2014	Cocaine- and amphetamine-regulated transcript peptide increases mitochondrial respiratory chain complex II activity and protects against oxygen-glucose deprivation in neurons.	oxygen-glucose	137-151	CART prepropeptide	Homo sapiens	0-45
24923428-10	2014	S100B-exposed astrocytes showed a pro-inflammatory phenotype with expression of Toll-like receptor 2 (TLR 2), inducible nitric oxide synthase (iNOS) and interleukin 1-beta (IL-1beta), and facilitated neuronal death induced by oxygen-glucose deprivation.	oxygen-glucose	226-240	S100 calcium binding protein B	Homo sapiens	0-5
24907101-0	2014	Inhibition of oxygen-glucose deprivation-induced apoptosis of human adipose-derived stem cells by genetic modification with antiapoptotic protein bcl-2.	oxygen-glucose	14-28	BCL2 apoptosis regulator	Homo sapiens	146-151
24907101-3	2014	In this study we aimed to inhibit oxygen-glucose deprivation (OGD)-induced apoptosis of human ADSCs by genetic modification with antiapoptotic protein Bcl-2.	oxygen-glucose	34-48	BCL2 apoptosis regulator	Homo sapiens	151-156
24705172-6	2014	In primary cultured rat neonatal ventricular myocytes subjected to hypoxia (oxygen-glucose deprivation), TREK-1 expression was increased.	oxygen-glucose	76-90	potassium two pore domain channel subfamily K member 2	Rattus norvegicus	105-111
24840287-0	2014	Resveratrol inhibits oxygen-glucose deprivation-induced MMP-3 expression and cell apoptosis in primary cortical cells via the NF-kappaB pathway.	oxygen-glucose	21-35	matrix metallopeptidase 3	Homo sapiens	56-61
24810044-6	2014	Indeed, the downregulation of OPN in primary and AML12 hepatocytes decreased cell viability in the basal state and sensitized AML12 hepatocytes to cell death induced by oxygen-glucose deprivation and TNFalpha.	oxygen-glucose	169-183	secreted phosphoprotein 1	Mus musculus	30-33
25076846-1	2014	Bcrp1/ABCG2 is exclusively expressed in side population (SP) cells, however, it has not been fully elucidated whether it has an impact on the viability, proliferation and paracrine actions in kidney SP cells under oxygen-glucose deprivation (OGD) followed by reoxygenation.	oxygen-glucose	214-228	BCR pseudogene 1	Homo sapiens	0-5
24295341-4	2014	RESULTS: Proteomic analysis in endothelial cells revealed that Prx1 was upregulated after stress-related oxygen-glucose deprivation (OGD).	oxygen-glucose	105-119	peroxiredoxin 1	Mus musculus	63-67
24589120-6	2014	Cultured OLs from TLR2 deficient mice were more vulnerable to oxygen-glucose deprivation than WT OLs.	oxygen-glucose	62-76	toll-like receptor 2	Mus musculus	18-22
24589120-7	2014	Applying TLR2 agonists Pam3CSK4 or Zymosan after oxygen-glucose deprivation substantially rescued WT OL death with augmentation of ERK1/2 phosphorylation.	oxygen-glucose	49-63	toll-like receptor 2	Mus musculus	9-13
24675027-7	2014	Surprisingly, the ability of t-PA to affect the barrier was lost under conditions of oxygen-glucose deprivation (OGD).	oxygen-glucose	85-99	plasminogen activator, tissue type	Homo sapiens	29-33
24750959-6	2014	Oxygen-glucose deprivation (OGD) stress increased the secretion of visfatin from glia.	oxygen-glucose	0-14	nicotinamide phosphoribosyltransferase	Mus musculus	67-75
24924720-0	2014	[Effects of 12/15-lipoxygenase antisense oligonucleotide on peroxisome proliferator-activated receptor gamma translocation in primarily cultured cortical neurons after oxygen-glucose deprivation].	oxygen-glucose	168-182	peroxisome proliferator activated receptor gamma	Homo sapiens	60-108
24924720-1	2014	OBJECTIVE: To explore the effects of 12/15-lipoxygenase antisense oligonucleotide (asON-12/15-LOX) on OGD (oxygen-glucose deprivation)-induced PPARgamma (peroxisome proliferator-activated receptor gamma) expression and nuclear translocation in primarily cultured cortical neurons.	oxygen-glucose	107-121	peroxisome proliferator activated receptor gamma	Homo sapiens	143-152
24924720-1	2014	OBJECTIVE: To explore the effects of 12/15-lipoxygenase antisense oligonucleotide (asON-12/15-LOX) on OGD (oxygen-glucose deprivation)-induced PPARgamma (peroxisome proliferator-activated receptor gamma) expression and nuclear translocation in primarily cultured cortical neurons.	oxygen-glucose	107-121	peroxisome proliferator activated receptor gamma	Homo sapiens	154-202
24275196-9	2014	Our results demonstrate that CAVI-b expression, which is increased through CHOP-signaling in response to unfolded protein stress, is also increased by oxygen-glucose deprivation (OGD).	oxygen-glucose	151-165	DNA damage inducible transcript 3	Homo sapiens	75-79
24743739-4	2014	14-3-3gamma, but not other 14-3-3 isoforms, was upregulated in primary cerebral cortical neurons upon oxygen-glucose deprivation (OGD) as measured by quantitative PCR, western blot and fluorescent immunostaining.	oxygen-glucose	102-116	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma	Homo sapiens	0-11
24486887-0	2014	AP4M1 is abnormally expressed in oxygen-glucose deprived hippocampal neurons.	oxygen-glucose	33-47	adaptor related protein complex 4 subunit mu 1	Homo sapiens	0-5
24382215-0	2014	Oxygen-glucose-deprived rat primary neural cells exhibit DJ-1 translocation into healthy mitochondria: a potent stroke therapeutic target.	oxygen-glucose	0-14	Parkinsonism associated deglycase	Rattus norvegicus	57-61
24043570-4	2014	In human umbilical vein endothelial cells, TRPM4 expression was increased at both the mRNA and protein levels following oxygen-glucose deprivation.	oxygen-glucose	120-134	transient receptor potential cation channel subfamily M member 4	Homo sapiens	43-48
24573298-3	2014	Here, we show that after focal cerebral ischemia in vivo or oxygen-glucose deprivation in organotypic hippocampal slices or neurons, p75(NTR) is rapidly induced.	oxygen-glucose	60-74	nerve growth factor receptor (TNFR superfamily, member 16)	Mus musculus	133-136
24573298-3	2014	Here, we show that after focal cerebral ischemia in vivo or oxygen-glucose deprivation in organotypic hippocampal slices or neurons, p75(NTR) is rapidly induced.	oxygen-glucose	60-74	nerve growth factor receptor (TNFR superfamily, member 16)	Mus musculus	137-140
24573298-5	2014	Induction of this ligand/receptor system is pathologically relevant, as a decrease in apoptosis, after oxygen-glucose deprivation, is observed in hippocampal neurons or slices after delivery of function-blocking antibodies to p75(NTR) or proNGF and in p75(NTR) and ngf haploinsufficient slices.	oxygen-glucose	103-117	nerve growth factor receptor (TNFR superfamily, member 16)	Mus musculus	226-229
24573298-5	2014	Induction of this ligand/receptor system is pathologically relevant, as a decrease in apoptosis, after oxygen-glucose deprivation, is observed in hippocampal neurons or slices after delivery of function-blocking antibodies to p75(NTR) or proNGF and in p75(NTR) and ngf haploinsufficient slices.	oxygen-glucose	103-117	nerve growth factor receptor (TNFR superfamily, member 16)	Mus musculus	230-233
24397751-4	2014	RESULTS: The current data showed that pretreatment with a specific eNOS inhibitor, L-N5-(1-iminoethyl) ornithine (L-NIO), aggravated the neuronal loss in the rat cerebral ischemic model, accompanied by reduction in brain-derived neurotrophic factor (BDNF) level, which was consistent with the findings in an oxygen-glucose deprivation model (OGD) with two neuronal cells: primary rat cortical neurons and human neuroblastoma SH-SY5Y cells.	oxygen-glucose	308-322	nitric oxide synthase 3	Rattus norvegicus	67-71
24186965-6	2014	Brain slices from AQP4(-/-) mice showed significantly reduced cell swelling and cytotoxicity in response to oxygen-glucose deprivation, compared with slices from AQP4(+/+) mice.	oxygen-glucose	108-122	aquaporin 4	Mus musculus	18-22
24372803-0	2014	Reactive oxygen species-caspase-3 relationship in mediating blood-brain barrier endothelial cell hyperpermeability following oxygen-glucose deprivation and reoxygenation.	oxygen-glucose	125-139	caspase 3	Homo sapiens	24-33
24748101-4	2014	Both neuron-specific RNA interference and neurons derived from CBP heterozygous knockout mice showed increased damage after oxygen-glucose deprivation (OGD) in vitro.	oxygen-glucose	124-138	CREB binding protein	Mus musculus	63-66
24256503-2	2014	METHODS AND RESULTS: In the present study, we found that oxygen-glucose deprivation (OGD) resulted in BV-2 cells activation, significantly increased tumor necrosis factor-alpha and interleukin-1beta (IL-1beta) levels, accompanied by downregulating Kir6.1 subunit.	oxygen-glucose	57-71	tumor necrosis factor	Mus musculus	149-176
24256503-2	2014	METHODS AND RESULTS: In the present study, we found that oxygen-glucose deprivation (OGD) resulted in BV-2 cells activation, significantly increased tumor necrosis factor-alpha and interleukin-1beta (IL-1beta) levels, accompanied by downregulating Kir6.1 subunit.	oxygen-glucose	57-71	interleukin 1 beta	Mus musculus	181-198
24256503-2	2014	METHODS AND RESULTS: In the present study, we found that oxygen-glucose deprivation (OGD) resulted in BV-2 cells activation, significantly increased tumor necrosis factor-alpha and interleukin-1beta (IL-1beta) levels, accompanied by downregulating Kir6.1 subunit.	oxygen-glucose	57-71	interleukin 1 beta	Mus musculus	200-208
24256503-2	2014	METHODS AND RESULTS: In the present study, we found that oxygen-glucose deprivation (OGD) resulted in BV-2 cells activation, significantly increased tumor necrosis factor-alpha and interleukin-1beta (IL-1beta) levels, accompanied by downregulating Kir6.1 subunit.	oxygen-glucose	57-71	potassium inwardly-rectifying channel, subfamily J, member 8	Mus musculus	248-254
24503888-5	2014	METHODS: Based on the use of endothelial cells expressing, or not expressing, the human SSAO/VAP-1 protein, we have set up an easy ischemic model using oxygen-glucose deprivation (OGD) as an experimental approach to the stroke process.	oxygen-glucose	152-166	amine oxidase copper containing 3	Homo sapiens	88-92
24431454-0	2014	BDNF mediates neuroprotection against oxygen-glucose deprivation by the cardiac glycoside oleandrin.	oxygen-glucose	38-52	brain derived neurotrophic factor	Homo sapiens	0-4
24045949-3	2013	We also observed that PAC1 expression in Neuro2a cells was transiently suppressed during in vitro ischemic conditions, oxygen-glucose deprivation (OGD).	oxygen-glucose	119-133	adenylate cyclase activating polypeptide 1 receptor 1	Mus musculus	22-26
24938773-9	2014	Isoflurane postconditioning and the Notch inhibitor inhibited 1 ng/ml lipopolysaccharide- and oxygen-glucose deprivation-induced Notch activation and proinflammatory cytokine production from microglial cultures.	oxygen-glucose	94-108	notch receptor 1	Rattus norvegicus	36-41
24938773-9	2014	Isoflurane postconditioning and the Notch inhibitor inhibited 1 ng/ml lipopolysaccharide- and oxygen-glucose deprivation-induced Notch activation and proinflammatory cytokine production from microglial cultures.	oxygen-glucose	94-108	notch receptor 1	Rattus norvegicus	129-134
23831681-7	2014	Similarly, lymphocytes were neuroprotective against oxygen-glucose deprivation (OGD)-induced cell death with the inhibition of p38 MAPK and ERK signalling pathways involved.	oxygen-glucose	52-66	mitogen-activated protein kinase 14	Homo sapiens	127-130
25206644-0	2013	Oxygen-glucose deprivation of neurons transfected with toll-like receptor 3-siRNA: Determination of an optimal transfection sequence.	oxygen-glucose	0-14	toll-like receptor 3	Rattus norvegicus	55-75
25206644-5	2013	These results suggested that siRNA-1724 is an optimal sequence for inhibiting toll-like receptor 3 expression in cortical neurons following oxygen-glucose deprivation.	oxygen-glucose	140-154	toll-like receptor 3	Rattus norvegicus	78-98
24244400-0	2013	Pretreatment with apoaequorin protects hippocampal CA1 neurons from oxygen-glucose deprivation.	oxygen-glucose	68-82	carbonic anhydrase 1	Rattus norvegicus	51-54
24376419-8	2013	Furthermore, we showed that Rd increased the levels of phosphorylated protein kinase B (PKB/Akt) and phospho-ERK1/2 (p-ERK1/2) in astrocyte culture after oxygen-glucose deprivation.	oxygen-glucose	154-168	AKT serine/threonine kinase 1	Rattus norvegicus	88-95
24376419-8	2013	Furthermore, we showed that Rd increased the levels of phosphorylated protein kinase B (PKB/Akt) and phospho-ERK1/2 (p-ERK1/2) in astrocyte culture after oxygen-glucose deprivation.	oxygen-glucose	154-168	mitogen activated protein kinase 3	Rattus norvegicus	109-115
24376419-8	2013	Furthermore, we showed that Rd increased the levels of phosphorylated protein kinase B (PKB/Akt) and phospho-ERK1/2 (p-ERK1/2) in astrocyte culture after oxygen-glucose deprivation.	oxygen-glucose	154-168	mitogen activated protein kinase 3	Rattus norvegicus	119-125
23772688-3	2013	In this study by employing an oxygen-glucose deprivation (OGD) neuronal model, we explored the function of PINK1 in cerebral ischemia.	oxygen-glucose	30-44	PTEN induced kinase 1	Homo sapiens	107-112
23772688-11	2013	In this study by employing an oxygen-glucose deprivation (OGD) neuronal model, we explored the function of PINK1 in cerebral ischemia.	oxygen-glucose	30-44	PTEN induced kinase 1	Homo sapiens	107-112
23770272-2	2013	In this study, we explored the potential effects of H2S on oxygen-glucose deprivation/reoxygenation (OGD/R)-induced neuronal apoptosis and the possible mechanisms.	oxygen-glucose	59-73	histocompatibility 2, S region (C4, Slp, Bf, C2)	Mus musculus	52-55
23748856-11	2013	CONCLUSIONS: Starting mild hypothermia simultaneously with oxygen-glucose deprivation, compared with delayed starting or no hypothermia, has higher pyruvate carboxylase throughput, suggesting that better glial integrity is one important neuroprotection mechanism of earlier hypothermia.	oxygen-glucose	59-73	pyruvate carboxylase	Homo sapiens	148-168
24229686-3	2013	Cbl-b belongs to the Casitas B-lineage lymphoma (Cbl) family, and it can regulate the cell signal transduction.The roles of ubiquitin ligase Cbl-b and PI3K/Akt pathway and the relationship between them in oxygen-glucose deprivation preconditioning (OGDPC) in PC12 cells were investigated in the present study.	oxygen-glucose	205-219	Cbl proto-oncogene B	Rattus norvegicus	0-5
24229686-3	2013	Cbl-b belongs to the Casitas B-lineage lymphoma (Cbl) family, and it can regulate the cell signal transduction.The roles of ubiquitin ligase Cbl-b and PI3K/Akt pathway and the relationship between them in oxygen-glucose deprivation preconditioning (OGDPC) in PC12 cells were investigated in the present study.	oxygen-glucose	205-219	Cbl proto-oncogene	Rattus norvegicus	21-47
24229686-3	2013	Cbl-b belongs to the Casitas B-lineage lymphoma (Cbl) family, and it can regulate the cell signal transduction.The roles of ubiquitin ligase Cbl-b and PI3K/Akt pathway and the relationship between them in oxygen-glucose deprivation preconditioning (OGDPC) in PC12 cells were investigated in the present study.	oxygen-glucose	205-219	Cbl proto-oncogene	Rattus norvegicus	0-3
24229686-3	2013	Cbl-b belongs to the Casitas B-lineage lymphoma (Cbl) family, and it can regulate the cell signal transduction.The roles of ubiquitin ligase Cbl-b and PI3K/Akt pathway and the relationship between them in oxygen-glucose deprivation preconditioning (OGDPC) in PC12 cells were investigated in the present study.	oxygen-glucose	205-219	AKT serine/threonine kinase 1	Rattus norvegicus	156-159
23702310-3	2013	Using rat hippocampal slices, we detected oxygen-glucose deprivation (OGD) induced slow inward currents (SICs) mediated by extrasynaptic NMDA receptors in CA1 pyramidal neurons.	oxygen-glucose	42-56	carbonic anhydrase 1	Rattus norvegicus	155-158
23692407-5	2013	In primary oligodendrocyte progenitor cell (OPC) cultures exposed to oxygen-glucose deprivation, we found that BNIP3 was upregulated and levels of BNIP3 expression correlated with the death of OPCs.	oxygen-glucose	69-83	BCL2 interacting protein 3	Rattus norvegicus	111-116
23692407-5	2013	In primary oligodendrocyte progenitor cell (OPC) cultures exposed to oxygen-glucose deprivation, we found that BNIP3 was upregulated and levels of BNIP3 expression correlated with the death of OPCs.	oxygen-glucose	69-83	BCL2 interacting protein 3	Rattus norvegicus	147-152
23760988-0	2013	Mesencephalic astrocyte-derived neurotrophic factor inhibits oxygen-glucose deprivation-induced cell damage and inflammation by suppressing endoplasmic reticulum stress in rat primary astrocytes.	oxygen-glucose	61-75	mesencephalic astrocyte-derived neurotrophic factor	Rattus norvegicus	0-51
23760988-3	2013	This current study investigates whether mesencephalic astrocyte-derived neurotrophic factor (MANF) inhibits oxygen-glucose deprivation (OGD)-induced cell damage and inflammatory cytokine secretion by suppressing endoplasmic reticulum stress in rat primary astrocytes.	oxygen-glucose	108-122	mesencephalic astrocyte-derived neurotrophic factor	Rattus norvegicus	40-91
23760988-3	2013	This current study investigates whether mesencephalic astrocyte-derived neurotrophic factor (MANF) inhibits oxygen-glucose deprivation (OGD)-induced cell damage and inflammatory cytokine secretion by suppressing endoplasmic reticulum stress in rat primary astrocytes.	oxygen-glucose	108-122	mesencephalic astrocyte-derived neurotrophic factor	Rattus norvegicus	93-97
24135936-1	2013	To investigate the role of mitochondria in the protective effects of ginsenoside Rb1 on cellular apoptosis caused by oxygen-glucose deprivation, in this study, MTT assay, TUNEL staining, flow cytometry, immunocytochemistry and western blotting were used to examine the cellular viability, apoptosis, ROS level, mitochondrial membrane potential, and the distribution of apoptosis inducing factor, cytochrome c, Bax and Bcl-2 in nucleus, mitochondria and cytoplasm.	oxygen-glucose	117-131	RB transcriptional corepressor 1	Homo sapiens	81-84
23224583-0	2013	Minocycline reduces oxygen-glucose deprivation-induced PC12 cell cytotoxicity via matrix metalloproteinase-9, integrin beta1 and phosphorylated Akt modulation.	oxygen-glucose	20-34	matrix metallopeptidase 9	Rattus norvegicus	82-108
23770338-0	2013	P2X7 receptor activation regulates microglial cell death during oxygen-glucose deprivation.	oxygen-glucose	64-78	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	0-13
23224583-0	2013	Minocycline reduces oxygen-glucose deprivation-induced PC12 cell cytotoxicity via matrix metalloproteinase-9, integrin beta1 and phosphorylated Akt modulation.	oxygen-glucose	20-34	integrin subunit beta 1	Rattus norvegicus	110-124
23224583-0	2013	Minocycline reduces oxygen-glucose deprivation-induced PC12 cell cytotoxicity via matrix metalloproteinase-9, integrin beta1 and phosphorylated Akt modulation.	oxygen-glucose	20-34	AKT serine/threonine kinase 1	Rattus norvegicus	144-147
23727062-12	2013	These results suggest that Cdh1 plays an important role in the regulation of reactive astrocyte proliferation induced by oxygen-glucose deprivation and reperfusion.	oxygen-glucose	121-135	cadherin 1	Homo sapiens	27-31
23727062-0	2013	Cdh1 inhibits reactive astrocyte proliferation after oxygen-glucose deprivation and reperfusion.	oxygen-glucose	53-67	cadherin 1	Homo sapiens	0-4
25206471-8	2013	Western blot and real-time PCR analysis showed that the Braintone-containing serum increased the levels of hypoxia-inducible factor 1alpha mRNA and protein, heme oxygenase-1 protein and vascular endothelial growth factor mRNA in oxygen-glucose deprived human umbilical vein endothelial cells.	oxygen-glucose	229-243	hypoxia inducible factor 1 subunit alpha	Homo sapiens	107-138
23903044-0	2013	Cinnamtannin B-1 regulates cell proliferation of spinal cord astrocytes and protects the cell from oxygen-glucose-serum deprivation/reoxygenation-induced apoptosis.	oxygen-glucose	99-113	immunoglobulin kappa variable 7-3 (pseudogene)	Homo sapiens	13-16
23903044-6	2013	We found that cinnamtannin B-1 protected astrocytes from oxygen-glucose-serum deprivation and reoxygenation-induced apoptosis.	oxygen-glucose	57-71	immunoglobulin kappa variable 7-3 (pseudogene)	Homo sapiens	27-30
23903044-8	2013	The results indicated that cinnamtannin B-1 protects astrocytes from oxygen-glucose-serum deprivation/reoxygenation-induced apoptosis by promoting astrocyte proliferation via an ERK pathway.	oxygen-glucose	69-83	immunoglobulin kappa variable 7-3 (pseudogene)	Homo sapiens	40-43
23224583-6	2013	Our results showed that minocycline could ameliorate oxygen-glucose deprivation-induced PC12 cell cytotoxicity at concentrations of 20 nM-20 muM, down-regulate the production and activity of matrix metalloproteinase-9, inhibit the degradation of integrin beta1, and up-regulate Akt phosphorylation at optimal concentration of 200 nM.	oxygen-glucose	53-67	matrix metallopeptidase 9	Rattus norvegicus	191-217
25206471-8	2013	Western blot and real-time PCR analysis showed that the Braintone-containing serum increased the levels of hypoxia-inducible factor 1alpha mRNA and protein, heme oxygenase-1 protein and vascular endothelial growth factor mRNA in oxygen-glucose deprived human umbilical vein endothelial cells.	oxygen-glucose	229-243	heme oxygenase 1	Homo sapiens	157-173
25206471-8	2013	Western blot and real-time PCR analysis showed that the Braintone-containing serum increased the levels of hypoxia-inducible factor 1alpha mRNA and protein, heme oxygenase-1 protein and vascular endothelial growth factor mRNA in oxygen-glucose deprived human umbilical vein endothelial cells.	oxygen-glucose	229-243	vascular endothelial growth factor A	Homo sapiens	186-220
23609497-4	2013	Then the correlation of Apobec-1 level and injury severity was analyzed in cells with oxygen-glucose deprivation and in rats with middle cerebral artery occlusion.	oxygen-glucose	86-100	apolipoprotein B mRNA editing enzyme catalytic subunit 1	Rattus norvegicus	24-32
23609497-5	2013	Apobec-1 expression was elevated along with upregulation of COX-2 and injury severity of oxygen-glucose deprivation in the three cell lines.	oxygen-glucose	89-103	apolipoprotein B mRNA editing enzyme catalytic subunit 1	Rattus norvegicus	0-8
23609497-6	2013	Apobec-1 overexpression aggravated injury of oxygen-glucose deprivation in vitro and could be correlated to injury severity in vivo.	oxygen-glucose	45-59	apolipoprotein B mRNA editing enzyme catalytic subunit 1	Rattus norvegicus	0-8
23142737-0	2013	Protective effects of erythropoietin on astrocytic swelling after oxygen-glucose deprivation and reoxygenation: mediation through AQP4 expression and MAPK pathway.	oxygen-glucose	66-80	erythropoietin	Homo sapiens	22-36
23591709-3	2013	We established an ex vivo model of HIE using oxygen-glucose deprivation (OGD) and demonstrated that miR-210 expression was upregulated in pheochromocytoma (PC12) cells after 4 h of OGD compared with normoxic controls.	oxygen-glucose	45-59	microRNA 210	Rattus norvegicus	100-107
23504235-0	2013	CaMKII activates ASK1 to induce apoptosis of spinal astrocytes under oxygen-glucose deprivation.	oxygen-glucose	69-83	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	0-6
23486469-7	2013	With tools for bidirectional control of the CaN-Drp1 signaling axis in hand, we demonstrate that the Drp1 LXVP motif shapes mitochondria in neuronal and non-neuronal cells, and that CaN-mediated Drp1 dephosphorylation promotes neuronal death following oxygen-glucose deprivation.	oxygen-glucose	252-266	dynamin 1 like	Homo sapiens	101-105
23486469-7	2013	With tools for bidirectional control of the CaN-Drp1 signaling axis in hand, we demonstrate that the Drp1 LXVP motif shapes mitochondria in neuronal and non-neuronal cells, and that CaN-mediated Drp1 dephosphorylation promotes neuronal death following oxygen-glucose deprivation.	oxygen-glucose	252-266	dynamin 1 like	Homo sapiens	101-105
25206395-0	2013	Activin A prevents neuron-like PC12 cell apoptosis after oxygen-glucose deprivation.	oxygen-glucose	57-71	inhibin subunit beta A	Rattus norvegicus	0-9
25206395-5	2013	Reverse transcription-PCR results revealed a significant increase in Activin receptor IIA, Smad3 and Smad4 mRNA levels, which are key sites in the Activin A/Smads signaling pathway, in neuron-like cells subjected to oxygen-glucose deprivation, while mRNA expression of the apoptosis-regulation gene caspase-3 decreased.	oxygen-glucose	216-230	activin A receptor type 2A	Rattus norvegicus	69-89
25206395-5	2013	Reverse transcription-PCR results revealed a significant increase in Activin receptor IIA, Smad3 and Smad4 mRNA levels, which are key sites in the Activin A/Smads signaling pathway, in neuron-like cells subjected to oxygen-glucose deprivation, while mRNA expression of the apoptosis-regulation gene caspase-3 decreased.	oxygen-glucose	216-230	SMAD family member 3	Rattus norvegicus	91-96
25206395-5	2013	Reverse transcription-PCR results revealed a significant increase in Activin receptor IIA, Smad3 and Smad4 mRNA levels, which are key sites in the Activin A/Smads signaling pathway, in neuron-like cells subjected to oxygen-glucose deprivation, while mRNA expression of the apoptosis-regulation gene caspase-3 decreased.	oxygen-glucose	216-230	SMAD family member 4	Rattus norvegicus	101-106
25206395-5	2013	Reverse transcription-PCR results revealed a significant increase in Activin receptor IIA, Smad3 and Smad4 mRNA levels, which are key sites in the Activin A/Smads signaling pathway, in neuron-like cells subjected to oxygen-glucose deprivation, while mRNA expression of the apoptosis-regulation gene caspase-3 decreased.	oxygen-glucose	216-230	inhibin subunit beta A	Rattus norvegicus	147-156
25206395-5	2013	Reverse transcription-PCR results revealed a significant increase in Activin receptor IIA, Smad3 and Smad4 mRNA levels, which are key sites in the Activin A/Smads signaling pathway, in neuron-like cells subjected to oxygen-glucose deprivation, while mRNA expression of the apoptosis-regulation gene caspase-3 decreased.	oxygen-glucose	216-230	caspase 3	Rattus norvegicus	299-308
23408111-3	2013	Here, we have demonstrated that (PPARgamma) activation by pioglitazone significantly inhibited both oxygen-glucose deprivation-induced cerebral vascular endothelial cell death and middle cerebral artery occlusion-triggered cerebrovascular damage.	oxygen-glucose	100-114	peroxisome proliferator activated receptor gamma	Mus musculus	33-42
23408111-7	2013	Furthermore, KLF11 genetic deficiency effectively abolished pioglitazone cytoprotection in mouse cerebral vascular endothelial cell cultures after oxygen-glucose deprivation, as well as pioglitazone-mediated cerebrovascular protection in a mouse middle cerebral artery occlusion model.	oxygen-glucose	147-161	Kruppel-like factor 11	Mus musculus	13-18
23325464-0	2013	Astrocyte-derived sonic hedgehog contributes to angiogenesis in brain microvascular endothelial cells via RhoA/ROCK pathway after oxygen-glucose deprivation.	oxygen-glucose	130-144	sonic hedgehog signaling molecule	Homo sapiens	18-32
23325464-0	2013	Astrocyte-derived sonic hedgehog contributes to angiogenesis in brain microvascular endothelial cells via RhoA/ROCK pathway after oxygen-glucose deprivation.	oxygen-glucose	130-144	ras homolog family member A	Homo sapiens	106-110
23458710-4	2013	In this study, we investigated the role of PTEN pathway in regulation of axon-dendrite polarity using an oxygen-glucose deprivation (OGD) model with rat cortical neurons.	oxygen-glucose	105-119	phosphatase and tensin homolog	Rattus norvegicus	43-47
23499476-6	2013	In vitro, RT-PCR results showed that the TGFbeta1 mRNA level was increased in both astrocytes and microglia/macrophages in an astrocyte-microglia/macrophage co-culture system after oxygen-glucose deprived (OGD) treatment.	oxygen-glucose	181-195	transforming growth factor, beta 1	Mus musculus	41-49
23504235-0	2013	CaMKII activates ASK1 to induce apoptosis of spinal astrocytes under oxygen-glucose deprivation.	oxygen-glucose	69-83	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	17-21
22946793-3	2013	Here, oxygen-glucose deprivation (OGD) exposure initiates the nuclear import of Keap1 in endothelial cells, which interacted with nuclear-localized Nrf2, as demonstrated through co-immunoprecipitation and immunocytochemical assay.	oxygen-glucose	6-20	kelch like ECH associated protein 1	Homo sapiens	80-85
22946793-3	2013	Here, oxygen-glucose deprivation (OGD) exposure initiates the nuclear import of Keap1 in endothelial cells, which interacted with nuclear-localized Nrf2, as demonstrated through co-immunoprecipitation and immunocytochemical assay.	oxygen-glucose	6-20	NFE2 like bZIP transcription factor 2	Homo sapiens	148-152
23841274-8	2013	CONCLUSIONS: Combination of ginseng and Ligusticum could promote the proliferation and vitality of rats" neural stem cells undergoing oxygen-glucose deprivation/reoxygenation culture through ERK signal pathway.	oxygen-glucose	134-148	Eph receptor B1	Rattus norvegicus	191-194
23333396-0	2013	Up-regulation of astroglial heme oxygenase-1 by a synthetic (S)-verbenone derivative LMT-335 ameliorates oxygen-glucose deprivation-evoked injury in cortical neurons.	oxygen-glucose	105-119	heme oxygenase 1	Rattus norvegicus	28-44
25206707-6	2013	In addition, penehyclidine hydrochloride inhibited the expression level of the NR1 subunit in hippocampal nerve cells in vitro following oxygen-glucose deprivation, as detected by PCR.	oxygen-glucose	137-151	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	79-82
25206673-0	2013	Expression of hypoxia-inducible factor 1 alpha and oligodendrocyte lineage gene-1 in cultured brain slices after oxygen-glucose deprivation.	oxygen-glucose	113-127	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	14-46
23199288-8	2013	Small interfering RNA specific for complement component 3 transfection showed a significant increase in brain cells viability after oxygen-glucose deprivation.	oxygen-glucose	132-146	complement component 3	Mus musculus	35-57
23072745-5	2013	Astrocytes from KO mice and neurons in which PHLPP1 was downregulated showed enhanced Akt activation and diminished cell death in response to oxygen-glucose deprivation.	oxygen-glucose	142-156	PH domain and leucine rich repeat protein phosphatase 1	Mus musculus	45-51
23192759-7	2013	In vitro oxygen-glucose deprivation (OGD) preconditioning was established in SH-SY5Y neuronal cells and in human microvascular endothelial cell-1 vascular endothelial cells.	oxygen-glucose	9-23	carboxyl ester lipase pseudogene	Homo sapiens	139-145
23032483-10	2013	Another key finding of the present study was that knockdown of DUSP8 in primary cultured cortical neurons that were subjected to oxygen-glucose deprivation diminished rosiglitazone"s effect on downregulation of JNK phosphorylation.	oxygen-glucose	129-143	dual specificity phosphatase 8	Mus musculus	63-68
25206376-0	2013	Dynamic changes in proprotein convertase 2 activity in cortical neurons after ischemia/reperfusion and oxygen-glucose deprivation.	oxygen-glucose	103-117	proprotein convertase subtilisin/kexin type 2	Rattus norvegicus	19-42
25206376-4	2013	These experimental findings indicate that proprotein convertase 2 activity decreases in ischemic rat cortex after reperfusion, as well as in cultured rat cortical neurons after oxygen-glucose deprivation.	oxygen-glucose	177-191	proprotein convertase subtilisin/kexin type 2	Rattus norvegicus	42-65
24457640-0	2013	Leukemia inhibitory factor inhibits the proliferation of primary rat astrocytes induced by oxygen-glucose deprivation.	oxygen-glucose	91-105	LIF, interleukin 6 family cytokine	Rattus norvegicus	0-26
24457640-2	2013	Oxygen-glucose deprivation (OGD) can induce astrocyte proliferation by increasing hypoxia-inducible factor alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF).	oxygen-glucose	0-14	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	114-124
24457640-2	2013	Oxygen-glucose deprivation (OGD) can induce astrocyte proliferation by increasing hypoxia-inducible factor alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF).	oxygen-glucose	0-14	vascular endothelial growth factor A	Rattus norvegicus	130-164
24457640-2	2013	Oxygen-glucose deprivation (OGD) can induce astrocyte proliferation by increasing hypoxia-inducible factor alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF).	oxygen-glucose	0-14	vascular endothelial growth factor A	Rattus norvegicus	166-170
23116637-0	2012	Baicalin attenuates proinflammatory cytokine production in oxygen-glucose deprived challenged rat microglial cells by inhibiting TLR4 signaling pathway.	oxygen-glucose	59-73	toll-like receptor 4	Rattus norvegicus	129-133
23086924-8	2012	Ischemia insult triggered by oxygen-glucose deprivation (OGD) enhances NRSF mRNA levels and then NRSF antagonizes the CREB signaling on CART activation, leading to augmented cell death.	oxygen-glucose	29-43	RE1 silencing transcription factor	Homo sapiens	71-75
23086924-8	2012	Ischemia insult triggered by oxygen-glucose deprivation (OGD) enhances NRSF mRNA levels and then NRSF antagonizes the CREB signaling on CART activation, leading to augmented cell death.	oxygen-glucose	29-43	cAMP responsive element binding protein 1	Homo sapiens	118-122
23086924-8	2012	Ischemia insult triggered by oxygen-glucose deprivation (OGD) enhances NRSF mRNA levels and then NRSF antagonizes the CREB signaling on CART activation, leading to augmented cell death.	oxygen-glucose	29-43	CART prepropeptide	Homo sapiens	136-140
23032401-2	2012	Our group has shown previously that A2aR-activated astrocytes occurred following oxygen-glucose deprivation.	oxygen-glucose	81-95	adenosine A2a receptor	Rattus norvegicus	36-40
23000062-3	2012	In this study, we demonstrated that the expression of PTN was induced in microglia after oxygen-glucose deprivation/reperfusion.	oxygen-glucose	89-103	pleiotrophin	Homo sapiens	54-57
23000454-0	2012	Beneficial effects of carbamylated erythropoietin against oxygen-glucose deprivation/reperfusion-induced astrocyte swelling: proposed molecular mechanisms of action.	oxygen-glucose	58-72	erythropoietin	Homo sapiens	35-49
23028052-4	2012	In this study, we used murine cells to demonstrate that both oxygen-glucose deprivation and pharmacologic unfolded protein response inducers trigger phosphorylation and nuclear translocation of IRF3, even in the absence of exogenous LPS.	oxygen-glucose	61-75	interferon regulatory factor 3	Mus musculus	194-198
22917477-0	2012	Change of Beclin-1 dependent on ATP, [Ca(2+)](i) and MMP in PC12 cells following oxygen-glucose deprivation-reoxygenation injury.	oxygen-glucose	81-95	beclin 1	Rattus norvegicus	10-18
23028052-5	2012	Different ER stressors used distinct mechanisms to activate IRF3: IRF3 phosphorylation due to calcium-mobilizing ER stress (thapsigargin treatment, oxygen-glucose deprivation) critically depended upon stimulator of IFN gene, an ER-resident nucleic acid-responsive molecule.	oxygen-glucose	148-162	interferon regulatory factor 3	Mus musculus	60-64
23028052-5	2012	Different ER stressors used distinct mechanisms to activate IRF3: IRF3 phosphorylation due to calcium-mobilizing ER stress (thapsigargin treatment, oxygen-glucose deprivation) critically depended upon stimulator of IFN gene, an ER-resident nucleic acid-responsive molecule.	oxygen-glucose	148-162	interferon regulatory factor 3	Mus musculus	66-70
22789015-10	2012	Interestingly, FasL generation in cultured microglia cells subjected to oxygen-glucose deprivation-treated neuron-conditioned medium was prevented by the silencing of P2X(7).	oxygen-glucose	72-86	Fas ligand (TNF superfamily, member 6)	Mus musculus	15-19
23056085-10	2012	Compared with the oxygen-glucose deprivation group, the apoptosis rate of C2C12 cells induced by hypoxia/reoxygenation in the TAT-CAIII group decreased significantly (p < 0.001).	oxygen-glucose	18-32	carbonic anhydrase 3	Mus musculus	130-135
22659017-0	2012	Mitochondrial distribution of neuroglobin and its response to oxygen-glucose deprivation in primary-cultured mouse cortical neurons.	oxygen-glucose	62-76	neuroglobin	Mus musculus	30-41
22274870-1	2012	Integrin beta8 is a key regulator of vascular homeostasis in brain development and in vitro studies show that beta8 protects against oxygen-glucose deprivation-induced neuronal apoptosis.	oxygen-glucose	133-147	integrin subunit beta 8	Rattus norvegicus	0-14
22869019-0	2012	Geniposide reduces inflammatory responses of oxygen-glucose deprived rat microglial cells via inhibition of the TLR4 signaling pathway.	oxygen-glucose	45-59	toll-like receptor 4	Rattus norvegicus	112-116
22958338-0	2012	NADPH oxidase mediates the oxygen-glucose deprivation/reperfusion-induced increase in the tyrosine phosphorylation of the N-methyl-D-aspartate receptor NR2A subunit in retinoic acid differentiated SH-SY5Y Cells.	oxygen-glucose	27-41	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	152-156
22789015-10	2012	Interestingly, FasL generation in cultured microglia cells subjected to oxygen-glucose deprivation-treated neuron-conditioned medium was prevented by the silencing of P2X(7).	oxygen-glucose	72-86	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	167-173
22366434-0	2012	Tong Luo Jiu Nao injection, a traditional Chinese medicinal preparation, inhibits MIP-1beta expression in brain microvascular endothelial cells injured by oxygen-glucose deprivation.	oxygen-glucose	155-169	C-C motif chemokine ligand 4	Homo sapiens	82-91
22578249-4	2012	We also observed up-regulation of Jmjd3 gene expression in bEnd.3 endothelial cells that were subjected to oxygen-glucose deprivation/reperfusion injury.	oxygen-glucose	107-121	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	34-39
22578249-5	2012	When Jmjd3 was depleted by siRNA, oxygen-glucose deprivation/reperfusion injury-induced up-regulation of IL-6 was significantly inhibited.	oxygen-glucose	34-48	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	5-10
22578249-5	2012	When Jmjd3 was depleted by siRNA, oxygen-glucose deprivation/reperfusion injury-induced up-regulation of IL-6 was significantly inhibited.	oxygen-glucose	34-48	interleukin 6	Mus musculus	105-109
22492561-11	2012	Treatment of primary cortical neurons, mixed glial cultures or immortalized brain endothelia with interleukin 6-induced robust interleukin-6 messenger RNA transcription in each case, whereas oxygen-glucose deprivation did not.	oxygen-glucose	191-205	interleukin 6	Mus musculus	98-111
22492561-12	2012	However, oxygen-glucose deprivation of organotypic brain slices resulted in strong upregulation of interleukin-6 messenger RNA along with increased transcription of key angiogenesis-associated genes.	oxygen-glucose	9-23	interleukin 6	Mus musculus	99-112
22554613-0	2012	17beta-Estradiol prevents cell death and mitochondrial dysfunction by an estrogen receptor-dependent mechanism in astrocytes after oxygen-glucose deprivation/reperfusion.	oxygen-glucose	131-145	estrogen receptor 1	Homo sapiens	73-90
22366181-5	2012	Moreover, in vitro oxygen-glucose deprivation (OGD) and subsequent reoxygenation without glucose and in vivo administration of 3-nitropropionic acid also promoted an increase in Txnip in a time-dependent manner, indicating that oxidative stress without glucose can induce Txnip expression in the brain.	oxygen-glucose	19-33	thioredoxin interacting protein	Mus musculus	178-183
21557879-6	2012	CS-A, by opening the BKCa channel, could prevent excessive glutamate release after oxygen-glucose deprivation (OGD).	oxygen-glucose	83-97	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	21-25
21725824-0	2011	Major role of the PI3K/Akt pathway in ischemic tolerance induced by sublethal oxygen-glucose deprivation in cortical neurons in vitro.	oxygen-glucose	78-92	AKT serine/threonine kinase 1	Rattus norvegicus	23-26
22594326-4	2012	(Cx43)Sca-1(+) showed improved survival under lethal oxygen-glucose deprivation culture conditions.	oxygen-glucose	53-67	gap junction protein, alpha 1	Rattus norvegicus	1-5
22594326-4	2012	(Cx43)Sca-1(+) showed improved survival under lethal oxygen-glucose deprivation culture conditions.	oxygen-glucose	53-67	caspase 3	Rattus norvegicus	6-11
22386494-0	2012	Nerve growth factor and brain-derived neurotrophic factor but not granulocyte colony-stimulating factor, nimodipine and dizocilpine, require ATP for neuroprotective activity after oxygen-glucose deprivation of primary neurons.	oxygen-glucose	180-194	nerve growth factor	Rattus norvegicus	0-19
22386494-0	2012	Nerve growth factor and brain-derived neurotrophic factor but not granulocyte colony-stimulating factor, nimodipine and dizocilpine, require ATP for neuroprotective activity after oxygen-glucose deprivation of primary neurons.	oxygen-glucose	180-194	brain-derived neurotrophic factor	Rattus norvegicus	24-57
22381744-0	2012	[Role of P38 signaling pathway in neonatal rat astrocyte swelling and aquaporin-4 expression after oxygen-glucose deprivation and recovery].	oxygen-glucose	99-113	mitogen activated protein kinase 14	Rattus norvegicus	9-12
22381744-0	2012	[Role of P38 signaling pathway in neonatal rat astrocyte swelling and aquaporin-4 expression after oxygen-glucose deprivation and recovery].	oxygen-glucose	99-113	aquaporin 4	Rattus norvegicus	70-81
22381744-1	2012	OBJECTIVE: To explore the role of P38 signaling pathway in neonatal rat astrocyte swelling and the expression of aquaporin-4 (AQP4) after oxygen-glucose deprivation (OGD) and recovery (OGD/R).	oxygen-glucose	138-152	aquaporin 4	Rattus norvegicus	113-124
22381744-1	2012	OBJECTIVE: To explore the role of P38 signaling pathway in neonatal rat astrocyte swelling and the expression of aquaporin-4 (AQP4) after oxygen-glucose deprivation (OGD) and recovery (OGD/R).	oxygen-glucose	138-152	aquaporin 4	Rattus norvegicus	126-130
22238093-4	2012	We found that prohibitin is upregulated also in the ischemic tolerance induced by transient ischemia in vivo, or oxygen-glucose deprivation in neuronal cultures.	oxygen-glucose	113-127	prohibitin 1	Rattus norvegicus	14-24
22761898-10	2012	An inhibitor of tissue non-specific alkaline phosphatase (TNAP) was found to attenuate the inhibitory effects of AMP and ATP, increase basal synaptic activity and reduce responses to oxygen-glucose deprivation selectively in slices from CD73(-/-) mice.	oxygen-glucose	183-197	alkaline phosphatase, liver/bone/kidney	Mus musculus	16-56
22761898-10	2012	An inhibitor of tissue non-specific alkaline phosphatase (TNAP) was found to attenuate the inhibitory effects of AMP and ATP, increase basal synaptic activity and reduce responses to oxygen-glucose deprivation selectively in slices from CD73(-/-) mice.	oxygen-glucose	183-197	alkaline phosphatase, liver/bone/kidney	Mus musculus	58-62
22210170-0	2011	Neuroprotective effects of exogenous activin A on oxygen-glucose deprivation in PC12 cells.	oxygen-glucose	50-64	inhibin subunit beta A	Rattus norvegicus	37-46
21587268-3	2011	Each of the four TRPM2 inhibitors tested provided significant protection to male neurons following in vitro ischemia (oxygen-glucose deprivation, OGD), while having no effect in female neurons.	oxygen-glucose	118-132	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	17-22
21817151-11	2011	In addition, NB-3 deficiency renders neurons more susceptible to oxygen-glucose deprivation-induced damage and NB-3 as substrate could partially through homophilic mechanisms.	oxygen-glucose	65-79	contactin 6	Mus musculus	13-17
21497193-1	2011	beta-Catenin stabilization achieved either via GSK-3beta specific inhibition or involving canonical Wnt signalling pathway, contributes to neuroprotection in an oxygen-glucose deprivation (4h OGD) in vitro hypoxia model performed on human cortical neural progenitor cells previously differentiated into neurons and glia.	oxygen-glucose	161-175	catenin beta 1	Homo sapiens	0-12
21487014-2	2011	This study aimed to explore whether magnesium was transported via a TRPM7 channel into the intracellular space of rat hippocampal neurons after 1 h of oxygen-glucose deprivation (OGD) and acute chemical ischemia (CI) by using methods of the Mg(2+) fluorescent probe Mag-Fura-2 to detect intracellular magnesium concentration ([Mg(2+)](i)) and flame atomic absorption spectrometry to measure extracellular magnesium concentration ([Mg(2+)](o)).	oxygen-glucose	151-165	transient receptor potential cation channel, subfamily M, member 7	Rattus norvegicus	68-73
22244880-0	2012	Oxygen-glucose deprivation (OGD) and interleukin-1 (IL-1) differentially modulate cathepsin B/L mediated generation of neuroprotective perlecan LG3 by neurons.	oxygen-glucose	0-14	cathepsin B	Homo sapiens	82-93
22937209-8	2012	miR-331 was also regulated by VPA pre-treatment in rat cortical neuronal cultures subjected to oxygen-glucose deprivation, an in vitro ischemic model.	oxygen-glucose	95-109	microRNA 331	Rattus norvegicus	0-7
21985437-0	2012	RIP1 mediates the protection of geldanamycin on neuronal injury induced by oxygen-glucose deprivation combined with zVAD in primary cortical neurons.	oxygen-glucose	75-89	receptor interacting serine/threonine kinase 1	Homo sapiens	0-4
21985437-5	2012	In this study, we showed that oxygen-glucose deprivation (OGD) combined with a caspase inhibitor zVAD (OGD/zVAD)-induced RIP1 protein expression in a time-dependent manner.	oxygen-glucose	30-44	receptor interacting serine/threonine kinase 1	Homo sapiens	121-125
22150679-0	2012	Dexmedetomidine protects against oxygen-glucose deprivation-induced injury through the I2 imidazoline receptor-PI3K/AKT pathway in rat C6 glioma cells.	oxygen-glucose	33-47	AKT serine/threonine kinase 1	Rattus norvegicus	116-119
21699926-4	2011	We first examined the neuroprotective effects of GDNF on oxygen-glucose deprivation (OGD) in NSCs.	oxygen-glucose	57-71	glial cell derived neurotrophic factor	Rattus norvegicus	49-53
21562306-9	2011	We found that hypoxia (7% and 2% O(2)), aglycemia, AVP, and oxygen-glucose deprivation (5- to 120-min exposures) increase activation of AMPK.	oxygen-glucose	60-74	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	136-140
21722091-2	2011	Here we illustrate that EPO relies upon the modulation of SIRT1 (silent mating type information regulator 2 homolog 1) in cerebral microvascular ECs to foster cytoprotection during oxygen-glucose deprivation (OGD).	oxygen-glucose	181-195	erythropoietin	Homo sapiens	24-27
21722091-2	2011	Here we illustrate that EPO relies upon the modulation of SIRT1 (silent mating type information regulator 2 homolog 1) in cerebral microvascular ECs to foster cytoprotection during oxygen-glucose deprivation (OGD).	oxygen-glucose	181-195	sirtuin 1	Homo sapiens	58-63
20969942-0	2011	Inactivation of GABA(A) receptor reduces ginsenoside Rb3 neuroprotection in mouse hippocampal slices after oxygen-glucose deprivation.	oxygen-glucose	107-121	stathmin-like 4	Mus musculus	53-56
21182899-3	2011	In this study, using a rat focal cerebral ischemia reperfusion (IR) model and an in vitro oxygen-glucose deprivation reperfusion (OGDR) system, we found that TLR2, IL-23 and IL-17 form an axis that leads to increased neuronal apoptosis.	oxygen-glucose	90-104	interleukin 17A	Rattus norvegicus	174-179
21210815-2	2011	We found that levels of proliferator-activated receptor gamma coactivator 1alpha and nuclear respiratory factor-1, mitochondrial DNA content and other markers of mitochondrial biogenesis and function were reduced in primary mouse cortical neurons under oxygen-glucose deprivation (OGD).	oxygen-glucose	253-267	nuclear respiratory factor 1	Mus musculus	24-113
21304968-4	2011	Cells expressing a GTP binding deficient form of TG2 (TG2-R580A) with high basal transamidation activity and a more extended conformation showed significantly increased cell death in response to oxygen-glucose deprivation; however, targeting TG2-R580A to the nucleus abrogated its detrimental role in oxygen-glucose deprivation.	oxygen-glucose	195-209	transglutaminase 2	Homo sapiens	49-52
21304968-4	2011	Cells expressing a GTP binding deficient form of TG2 (TG2-R580A) with high basal transamidation activity and a more extended conformation showed significantly increased cell death in response to oxygen-glucose deprivation; however, targeting TG2-R580A to the nucleus abrogated its detrimental role in oxygen-glucose deprivation.	oxygen-glucose	195-209	transglutaminase 2	Homo sapiens	54-59
21304968-4	2011	Cells expressing a GTP binding deficient form of TG2 (TG2-R580A) with high basal transamidation activity and a more extended conformation showed significantly increased cell death in response to oxygen-glucose deprivation; however, targeting TG2-R580A to the nucleus abrogated its detrimental role in oxygen-glucose deprivation.	oxygen-glucose	301-315	transglutaminase 2	Homo sapiens	49-52
21304968-4	2011	Cells expressing a GTP binding deficient form of TG2 (TG2-R580A) with high basal transamidation activity and a more extended conformation showed significantly increased cell death in response to oxygen-glucose deprivation; however, targeting TG2-R580A to the nucleus abrogated its detrimental role in oxygen-glucose deprivation.	oxygen-glucose	301-315	transglutaminase 2	Homo sapiens	54-59
21029239-4	2011	Conversely, applying 2ME2 to neurons 8 h after ischemic stress or silencing the HIF-1alpha with siRNA 12 h after oxygen-glucose deprivation (OGD) increased neuron damage and decreased vascular endothelial growth factor (VEGF) expression.	oxygen-glucose	113-127	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	80-90
21300054-4	2011	Kv2.1 transfected HEK293 cell line (Kv2.1/HEK293) was used to study oxygen-glucose deprivation (OGD) induced cell apoptosis.	oxygen-glucose	68-82	potassium voltage-gated channel subfamily B member 1	Homo sapiens	0-5
21255413-8	2011	For example, SDIM1 was significantly down regulated 2 h after oxygen-glucose deprivation (OGD), though had recovered 16 h later, and also appeared significantly up regulated compared to untreated NT2 neurons.	oxygen-glucose	62-76	stress responsive DNAJB4 interacting membrane protein 1	Homo sapiens	13-18
20445066-3	2010	Here we report for the first time that PPARdelta is significantly reduced in oxygen-glucose deprivation (OGD)-induced mouse CEC death.	oxygen-glucose	77-91	peroxisome proliferator activator receptor delta	Mus musculus	39-48
22040892-0	2011	Evidence for neuroprotective effect of sulbutiamine against oxygen-glucose deprivation in rat hippocampal CA1 pyramidal neurons.	oxygen-glucose	60-74	carbonic anhydrase 1	Rattus norvegicus	106-109
20588319-5	2011	The SIK1 knockdown by siRNA exacerbated oxygen-glucose deprivation (OGD)-induced cell death in primary cortical neurons, suggesting that SIK1 is an endogenous neuroprotective gene against cerebral ischemia.	oxygen-glucose	40-54	salt inducible kinase 1	Mus musculus	4-8
20588319-5	2011	The SIK1 knockdown by siRNA exacerbated oxygen-glucose deprivation (OGD)-induced cell death in primary cortical neurons, suggesting that SIK1 is an endogenous neuroprotective gene against cerebral ischemia.	oxygen-glucose	40-54	salt inducible kinase 1	Mus musculus	137-141
21602594-0	2011	Immunosuppressant cytoprotection correlates with HMGB1 suppression in primary astrocyte cultures exposed to combined oxygen-glucose deprivation.	oxygen-glucose	117-131	high mobility group box 1	Homo sapiens	49-54
21602594-2	2011	Because high-mobility group box 1 (HMGB1) protein has recently been reported to be involved in ischemic brain injury, the purpose of the present study was to determine whether treatment with immunosuppressants could decrease the expression and release of HMGB1 in astrocytes exposed to simulated ischemic conditions (combined oxygen-glucose deprivation, OGD).	oxygen-glucose	326-340	high mobility group box 1	Homo sapiens	35-40
21602594-2	2011	Because high-mobility group box 1 (HMGB1) protein has recently been reported to be involved in ischemic brain injury, the purpose of the present study was to determine whether treatment with immunosuppressants could decrease the expression and release of HMGB1 in astrocytes exposed to simulated ischemic conditions (combined oxygen-glucose deprivation, OGD).	oxygen-glucose	326-340	high mobility group box 1	Homo sapiens	255-260
22022421-7	2011	We also demonstrate that the h-TREK-1/HEK cell line is protected against ischemia by using the oxygen-glucose deprivation model.	oxygen-glucose	95-109	potassium two pore domain channel subfamily K member 2	Homo sapiens	31-37
20881608-6	2010	Using cultured adult rat cardiac myocytes, we evaluated the mechanism of minocycline protection in which PARP-1 activation was induced by simulated ischemia/reperfusion injury using oxygen-glucose deprivation.We found an increase in reactive oxygen species production, PARP-1 activation, and PARP-1-mediated cell death after simulated ischemia/reperfusion.	oxygen-glucose	182-196	poly (ADP-ribose) polymerase 1	Rattus norvegicus	105-111
20337950-0	2010	Small hairpin RNA interference of the Nogo receptor inhibits oxygen-glucose deprivation-induced damage in rat hippocampal slice cultures.	oxygen-glucose	61-75	reticulon 4 receptor	Rattus norvegicus	38-51
19953350-0	2010	Brain distribution of carboxy terminus of Hsc70-interacting protein (CHIP) and its nuclear translocation in cultured cortical neurons following heat stress or oxygen-glucose deprivation.	oxygen-glucose	159-173	ST13 Hsp70 interacting protein	Homo sapiens	42-67
20651275-2	2010	Using an in vitro model of the brain barrier composed of human brain microvascular endothelial cells and human astrocytes, this study explored whether small GTPase RhoA and its effector protein Rho kinase were involved in permeability changes mediated by oxygen-glucose deprivation (OGD), key pathological phenomena during ischemic stroke.	oxygen-glucose	255-269	ras homolog family member A	Homo sapiens	164-168
20815773-3	2010	Methyleugenol decreased the caspase-3 activation and death of cultured cerebral cortical neurons caused by oxygen-glucose deprivation (OGD) for 1 h and subsequent re-oxygenation for 24 h. Methyleugenol markedly reduced superoxide generation in the ischemic brain and decreased the intracellular oxidative stress caused by OGD/re-oxygenation.	oxygen-glucose	107-121	caspase 3	Homo sapiens	28-37
20599593-5	2010	Furthermore, when cultured in hypoxia or oxygen-glucose deprivation for 4h, GSPCs transcribed and expressed molecular markers of VEC, including CD31, CD34 and vWF.	oxygen-glucose	41-55	platelet and endothelial cell adhesion molecule 1	Homo sapiens	144-148
20599593-5	2010	Furthermore, when cultured in hypoxia or oxygen-glucose deprivation for 4h, GSPCs transcribed and expressed molecular markers of VEC, including CD31, CD34 and vWF.	oxygen-glucose	41-55	CD34 molecule	Homo sapiens	150-154
20599593-5	2010	Furthermore, when cultured in hypoxia or oxygen-glucose deprivation for 4h, GSPCs transcribed and expressed molecular markers of VEC, including CD31, CD34 and vWF.	oxygen-glucose	41-55	von Willebrand factor	Homo sapiens	159-162
20577577-7	2010	In vitro experiments showed that this EPO fusion protein retained all its protective properties against neuronal death elicited by oxygen-glucose deprivation and NMDA insults.	oxygen-glucose	131-145	erythropoietin	Mus musculus	38-41
21220102-2	2011	We found that salt-inducible kinase 2 (SIK2) was abundantly expressed in neurons and suppressed CREB-mediated gene expression after oxygen-glucose deprivation (OGD).	oxygen-glucose	132-146	salt inducible kinase 2	Mus musculus	14-37
21220102-2	2011	We found that salt-inducible kinase 2 (SIK2) was abundantly expressed in neurons and suppressed CREB-mediated gene expression after oxygen-glucose deprivation (OGD).	oxygen-glucose	132-146	salt inducible kinase 2	Mus musculus	39-43
21220102-2	2011	We found that salt-inducible kinase 2 (SIK2) was abundantly expressed in neurons and suppressed CREB-mediated gene expression after oxygen-glucose deprivation (OGD).	oxygen-glucose	132-146	cAMP responsive element binding protein 1	Mus musculus	96-100
21055410-2	2011	Here we investigated the mechanism underlying CysLT(2) receptor-mediated ischemic astrocyte injury induced by 4-h oxygen-glucose deprivation and 24-h recovery (OGD/R).	oxygen-glucose	114-128	cysteinyl leukotriene receptor 2	Rattus norvegicus	46-54
20932259-5	2011	Depletion of TRPM7 expression in brain, on the other hand, proved successful in mitigating much of the cellular devastation that accompanies oxygen-glucose deprivation during ischemia.	oxygen-glucose	141-155	transient receptor potential cation channel, subfamily M, member 7	Mus musculus	13-18
20863826-0	2010	Comprehensive study of baicalin down-regulating NOD2 receptor expression of neurons with oxygen-glucose deprivation in vitro and cerebral ischemia-reperfusion in vivo.	oxygen-glucose	89-103	nucleotide-binding oligomerization domain containing 2	Mus musculus	48-52
20863826-3	2010	Since baicalin has the pharmacological effects of anti-inflammation and protection of brain from cerebral ischemia-reperfusion, we studied baicalin"s effect on NOD2/TNFalpha in the cell of oxygen-glucose deprivation (OGD) in vitro and the mice of cerebral ischemia-reperfusion in vivo.	oxygen-glucose	189-203	nucleotide-binding oligomerization domain containing 2	Mus musculus	160-164
20863826-3	2010	Since baicalin has the pharmacological effects of anti-inflammation and protection of brain from cerebral ischemia-reperfusion, we studied baicalin"s effect on NOD2/TNFalpha in the cell of oxygen-glucose deprivation (OGD) in vitro and the mice of cerebral ischemia-reperfusion in vivo.	oxygen-glucose	189-203	tumor necrosis factor	Mus musculus	165-173
20863826-4	2010	The results showed that NOD2 and TNFalpha were up regulated in the cells with oxygen-glucose deprivation, not only in BV2 cells, but also in both of PC12 cells and primary neuron cells, which suggested NOD2 could express directly in neuron while OGD treatment.	oxygen-glucose	78-92	nucleotide-binding oligomerization domain containing 2	Mus musculus	24-28
20863826-4	2010	The results showed that NOD2 and TNFalpha were up regulated in the cells with oxygen-glucose deprivation, not only in BV2 cells, but also in both of PC12 cells and primary neuron cells, which suggested NOD2 could express directly in neuron while OGD treatment.	oxygen-glucose	78-92	tumor necrosis factor	Mus musculus	33-41
20863826-4	2010	The results showed that NOD2 and TNFalpha were up regulated in the cells with oxygen-glucose deprivation, not only in BV2 cells, but also in both of PC12 cells and primary neuron cells, which suggested NOD2 could express directly in neuron while OGD treatment.	oxygen-glucose	78-92	nucleotide-binding oligomerization domain containing 2	Rattus norvegicus	202-206
20444431-0	2010	EIF2alpha and caspase-12 activation are involved in oxygen-glucose-serum deprivation/restoration-induced apoptosis of spinal cord astrocytes.	oxygen-glucose	52-66	eukaryotic translation initiation factor 2A	Rattus norvegicus	0-9
20444431-0	2010	EIF2alpha and caspase-12 activation are involved in oxygen-glucose-serum deprivation/restoration-induced apoptosis of spinal cord astrocytes.	oxygen-glucose	52-66	caspase 12	Rattus norvegicus	14-24
20171195-9	2010	Moreover, co-culture of primary rat cells with the pEGFP/GDNF-transfected CD34+ cells promoted enhanced neuroprotection against oxygen-glucose deprivation induced cell dysfunctions.	oxygen-glucose	128-142	glial cell derived neurotrophic factor	Rattus norvegicus	57-61
20012228-0	2010	Nerve growth factor-induced protection of brain capillary endothelial cells exposed to oxygen-glucose deprivation involves attenuation of Erk phosphorylation.	oxygen-glucose	87-101	rolled	Drosophila melanogaster	138-141
20117210-2	2010	We have investigated the effect of erythropoietin (EPO) on oxygen-glucose deprived hippocampal slices and hypoxic progenitor cells.	oxygen-glucose	59-73	erythropoietin	Homo sapiens	35-49
20117210-2	2010	We have investigated the effect of erythropoietin (EPO) on oxygen-glucose deprived hippocampal slices and hypoxic progenitor cells.	oxygen-glucose	59-73	erythropoietin	Homo sapiens	51-54
20360540-8	2010	Importantly, we demonstrated that a PTEN inhibitor prevented the reduction of surface GABA(A)Rs in injured hippocampal neurons subjected to oxygen-glucose deprivation, an in vitro insult that mimics ischemic injury, whereas a GABA(A)R antagonist significantly reduced this PTEN inhibitor-induced neuroprotection in both the in vitro and in vivo ischemic stroke models.	oxygen-glucose	140-154	phosphatase and tensin homolog	Rattus norvegicus	36-40
20171195-9	2010	Moreover, co-culture of primary rat cells with the pEGFP/GDNF-transfected CD34+ cells promoted enhanced neuroprotection against oxygen-glucose deprivation induced cell dysfunctions.	oxygen-glucose	128-142	CD34 molecule	Rattus norvegicus	74-78
19823932-1	2010	Incubation of rat cortical slices in a medium that was not containing oxygen and glucose (oxygen-glucose deprivation, OGD) caused a 200% increase in the release of S100B.	oxygen-glucose	90-104	S100 calcium binding protein B	Rattus norvegicus	164-169
20450556-0	2010	[Effects of naloxone on the expression of stem cell factor and C-kit receptor in combined oxygen-glucose deprivation of primary cultured human embryonic neuron in vitro].	oxygen-glucose	90-104	KIT ligand	Homo sapiens	42-58
20053374-3	2010	Here, we found that miR-497 is induced in mouse brain after transient middle cerebral artery occlusion (MCAO) and mouse N2A neuroblastoma (N2A) cells after oxygen-glucose deprivation (OGD).	oxygen-glucose	156-170	microRNA 497	Mus musculus	20-27
20450556-10	2010	Immediately after oxygen-glucose deprivation, the expression of SCF/c-kit R mRNA increased significantly (P<0.01).	oxygen-glucose	18-32	KIT ligand	Homo sapiens	64-67
20450556-14	2010	CONCLUSIONS: The expression of SCF/c-kit R mRNA increases at the early stage after combined oxygen-glucose deprivation.	oxygen-glucose	92-106	KIT ligand	Homo sapiens	31-34
20147536-6	2010	Compared with C1q(+/+) neurons, cortical C1q(-/-) neurons exhibited resistance to oxygen-glucose deprivation.	oxygen-glucose	82-96	complement component 1, q subcomponent, alpha polypeptide	Mus musculus	41-44
19170684-5	2010	In vitro investigations demonstrated that mCRP was preferentially expressed in human brain microvessel endothelial cells following oxygen-glucose deprivation and mCRP (but not column purified nCRP) associated with the endothelial cell surface, and was angiogenic to vascular endothelial cells, stimulating migration and tube formation in matrigel more strongly than fibroblast growth factor-2.	oxygen-glucose	131-145	C-reactive protein, pentraxin-related	Mus musculus	42-46
20139896-0	2010	Baicalin attenuates oxygen-glucose deprivation-induced injury by inhibiting oxidative stress-mediated 5-lipoxygenase activation in PC12 cells.	oxygen-glucose	20-34	arachidonate 5-lipoxygenase	Rattus norvegicus	102-116
19610093-3	2009	Here, we first report that overexpression of the PDZ1 domain of PSD-95 protein exerts a protective role against neuronal death induced by cerebral ischemia-reperfusion in vivo and can prevent neuronal cell death induced by oxygen-glucose deprivation.	oxygen-glucose	223-237	discs large MAGUK scaffold protein 4	Homo sapiens	64-70
19780893-2	2009	We report here that oxygen-glucose deprivation (OGD), an in vitro insult mimicking ischemic neuron injury, resulted in a significant reduction of PINK1 protein expression in cultured cortical neurons.	oxygen-glucose	20-34	PTEN induced kinase 1	Homo sapiens	146-151
20508809-0	2010	S100b counteracts neurodegeneration of rat cholinergic neurons in brain slices after oxygen-glucose deprivation.	oxygen-glucose	85-99	S100 calcium binding protein B	Rattus norvegicus	0-5
20508809-2	2010	The aim of the present study is to test whether the glia-derived molecule S100b can counteract neurodegeneration of cholinergic neurons after oxygen-glucose deprivation (OGD) in organotypic brain slices of basal nucleus of Meynert.	oxygen-glucose	142-156	S100 calcium binding protein B	Rattus norvegicus	74-79
19737385-0	2009	Mitochondrial BNIP3 upregulation precedes endonuclease G translocation in hippocampal neuronal death following oxygen-glucose deprivation.	oxygen-glucose	111-125	BCL2 interacting protein 3	Homo sapiens	14-19
19576187-5	2009	More recently, mTOR has been found to enhance the survival of EOC2 microglia during oxygen-glucose deprivation and increase NO synthase 2 (NOS2) expression during hypoxia in BV2 microglial cell line, thus suggesting an involvement in microglial pro-inflammatory activation.	oxygen-glucose	84-98	mechanistic target of rapamycin kinase	Mus musculus	15-19
19449206-0	2009	Neuroprotection against transient focal cerebral ischemia and oxygen-glucose deprivation by interference with GluR6-PSD95 protein interaction.	oxygen-glucose	62-76	glutamate ionotropic receptor kainate type subunit 2	Rattus norvegicus	110-115
19449206-0	2009	Neuroprotection against transient focal cerebral ischemia and oxygen-glucose deprivation by interference with GluR6-PSD95 protein interaction.	oxygen-glucose	62-76	discs large MAGUK scaffold protein 4	Rattus norvegicus	116-121
19619518-0	2009	Delta opioid agonist [D-Ala2, D-Leu5] enkephalin (DADLE) reduced oxygen-glucose deprivation caused neuronal injury through the MAPK pathway.	oxygen-glucose	65-79	tripartite motif containing 13	Homo sapiens	30-36
19619518-0	2009	Delta opioid agonist [D-Ala2, D-Leu5] enkephalin (DADLE) reduced oxygen-glucose deprivation caused neuronal injury through the MAPK pathway.	oxygen-glucose	65-79	mitogen-activated protein kinase 1	Homo sapiens	127-131
19737385-4	2009	RESULTS: In this report, using western blot analysis and immunocytochemistry, we found that EndoG upregulates and translocates from mitochondria to nucleus in a time-dependent manner in cultured hippocampal neurons following oxygen-glucose deprivation (OGD).	oxygen-glucose	225-239	endonuclease G	Homo sapiens	92-97
19534718-0	2009	Peroxisome-proliferator-activated receptor-alpha activation protects brain capillary endothelial cells from oxygen-glucose deprivation-induced hyperpermeability in the blood-brain barrier.	oxygen-glucose	108-122	peroxisome proliferator activated receptor alpha	Mus musculus	0-48
19555759-0	2009	Activation of caspase-8 by tumour necrosis factor receptor 1 is necessary for caspase-3 activation and apoptosis in oxygen-glucose deprived cultured cortical cells.	oxygen-glucose	116-130	caspase 3	Mus musculus	78-87
19555759-3	2009	Here we show that TNF-alpha is released after oxygen-glucose deprivation (OGD) of cortical cultures and is a major contributor to the apoptotic death observed without affecting the OGD-mediated necrotic cell death.	oxygen-glucose	46-60	tumor necrosis factor	Mus musculus	18-27
19587218-11	2009	Moreover, inhibition of Cx32 HCs expressed by HeLa cells in low-confluence cultures drastically reduced cell death induced by oxygen-glucose deprivation, which is a more physiological model of ischemia-reperfusion.	oxygen-glucose	126-140	gap junction protein beta 1	Homo sapiens	24-28
19343277-0	2009	NMDA receptor dependent PGC-1alpha up-regulation protects the cortical neuron against oxygen-glucose deprivation/reperfusion injury.	oxygen-glucose	86-100	glutamate ionotropic receptor NMDA type subunit 1	Sus scrofa	0-13
19343277-0	2009	NMDA receptor dependent PGC-1alpha up-regulation protects the cortical neuron against oxygen-glucose deprivation/reperfusion injury.	oxygen-glucose	86-100	PPARG coactivator 1 alpha	Sus scrofa	24-34
19464284-5	2009	Oxygen-glucose deprivation and the subsequent simulated reperfusion increased LDH release and annexin V-positive staining cells, a characteristic of cell apoptosis.	oxygen-glucose	0-14	LDH	Bos taurus	78-81
19357264-8	2009	Furthermore, oxygen-glucose deprivation (OGD) preconditioning upregulated VEGF-A, VEGFR-2, and pCREB levels and protected immortalized H19-7 neuronal cells and b.End3 vascular endothelial cells against 24 h OGD cell death.	oxygen-glucose	13-27	vascular endothelial growth factor A	Rattus norvegicus	74-80
19379716-3	2009	In this study, we found that minocycline inhibited HMGB1 release in oxygen-glucose deprivation (OGD)-treated PC12 cells and triggered the activation of p38mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinases (ERK1/2).	oxygen-glucose	68-82	high mobility group box 1	Rattus norvegicus	51-56
19468252-7	2009	Exposure of human fetal brain neurons to oxygen-glucose deprivation also induced BTG2 expression in the cytoplasm and perinuclear regions of cells staining positive for propidium iodide (a marker of nuclear damage).	oxygen-glucose	41-55	BTG anti-proliferation factor 2	Homo sapiens	81-85
19422385-0	2009	The adenosine A2A receptor antagonist ZM241385 enhances neuronal survival after oxygen-glucose deprivation in rat CA1 hippocampal slices.	oxygen-glucose	80-94	adenosine A2a receptor	Rattus norvegicus	4-26
19422385-0	2009	The adenosine A2A receptor antagonist ZM241385 enhances neuronal survival after oxygen-glucose deprivation in rat CA1 hippocampal slices.	oxygen-glucose	80-94	carbonic anhydrase 1	Rattus norvegicus	114-117
19422385-1	2009	BACKGROUND AND PURPOSE: Activation of adenosine A(2A) receptors in the CA1 region of rat hippocampal slices during oxygen-glucose deprivation (OGD), a model of cerebral ischaemia, was investigated.	oxygen-glucose	115-129	carbonic anhydrase 1	Rattus norvegicus	71-74
19057019-6	2009	3K3A-APC protected mouse neurons from N-methyl-d-aspartate-induced apoptosis and human brain endothelial cell from oxygen-glucose deprivation with 1.8- and 3.1-fold greater efficacy than drotrecogin-alfa activated.	oxygen-glucose	115-129	APC, WNT signaling pathway regulator	Mus musculus	5-8
19357264-8	2009	Furthermore, oxygen-glucose deprivation (OGD) preconditioning upregulated VEGF-A, VEGFR-2, and pCREB levels and protected immortalized H19-7 neuronal cells and b.End3 vascular endothelial cells against 24 h OGD cell death.	oxygen-glucose	13-27	kinase insert domain receptor	Rattus norvegicus	82-89
19023096-7	2009	RESULTS: Leptin treatment activated the nuclear translocation of nuclear transcription factors kappaB dimers containing the c-Rel subunit, induced the expression of the antiapoptotic c-Rel target gene Bcl-xL in both control and oxygen-glucose deprivation conditions, and counteracted the oxygen-glucose deprivation-mediated apoptotic death of cultured cortical neurons.	oxygen-glucose	228-242	leptin	Mus musculus	9-15
19364322-6	2009	Ischemia (oxygen-glucose deprivation) significantly decreased secretion of cathepsin B activities into the culture medium.	oxygen-glucose	10-24	cathepsin B	Homo sapiens	75-86
18951527-0	2009	Oxygen-glucose deprivation activates 5-lipoxygenase mediated by oxidative stress through the p38 mitogen-activated protein kinase pathway in PC12 cells.	oxygen-glucose	0-14	arachidonate 5-lipoxygenase	Rattus norvegicus	37-51
18951527-0	2009	Oxygen-glucose deprivation activates 5-lipoxygenase mediated by oxidative stress through the p38 mitogen-activated protein kinase pathway in PC12 cells.	oxygen-glucose	0-14	mitogen activated protein kinase 14	Rattus norvegicus	93-96
19228841-3	2009	We investigated the roles of vascular endothelial growth factor (VEGF) and the downstream extracellular signal-regulated kinase (ERK) protein after oxygen-glucose deprivation (OGD) in primary endothelial cells.	oxygen-glucose	148-162	mitogen-activated protein kinase 1	Mus musculus	90-127
19228841-3	2009	We investigated the roles of vascular endothelial growth factor (VEGF) and the downstream extracellular signal-regulated kinase (ERK) protein after oxygen-glucose deprivation (OGD) in primary endothelial cells.	oxygen-glucose	148-162	mitogen-activated protein kinase 1	Mus musculus	129-132
19023096-7	2009	RESULTS: Leptin treatment activated the nuclear translocation of nuclear transcription factors kappaB dimers containing the c-Rel subunit, induced the expression of the antiapoptotic c-Rel target gene Bcl-xL in both control and oxygen-glucose deprivation conditions, and counteracted the oxygen-glucose deprivation-mediated apoptotic death of cultured cortical neurons.	oxygen-glucose	228-242	reticuloendotheliosis oncogene	Mus musculus	183-188
19023096-7	2009	RESULTS: Leptin treatment activated the nuclear translocation of nuclear transcription factors kappaB dimers containing the c-Rel subunit, induced the expression of the antiapoptotic c-Rel target gene Bcl-xL in both control and oxygen-glucose deprivation conditions, and counteracted the oxygen-glucose deprivation-mediated apoptotic death of cultured cortical neurons.	oxygen-glucose	228-242	BCL2-like 1	Mus musculus	201-207
19023096-8	2009	Leptin-mediated Bcl-xL induction and neuroprotection against oxygen-glucose deprivation were hampered in cortical neurons from c-Rel(-/-) mice.	oxygen-glucose	61-75	leptin	Mus musculus	0-6
19023096-8	2009	Leptin-mediated Bcl-xL induction and neuroprotection against oxygen-glucose deprivation were hampered in cortical neurons from c-Rel(-/-) mice.	oxygen-glucose	61-75	reticuloendotheliosis oncogene	Mus musculus	127-132
18203692-1	2008	We have recently found that in the mouse cortex, activation of delta-opioid receptor (DOR) attenuates the disruption of K(+) homeostasis induced by hypoxia or oxygen-glucose deprivation.	oxygen-glucose	159-173	opioid receptor, delta 1	Mus musculus	63-84
18616988-6	2009	Microelectrode array recordings revealed that oxygen-glucose deprivation enhances hippocampal network firing rates, which induces c-fos transcription through a signaling pathway that, in contrast to Clca1, is activated by synaptic but not extrasynaptic NMDA receptors.	oxygen-glucose	46-60	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	130-135
19526863-4	2009	The aim of the present study was to evaluate the neuronal, synaptic and glial plasticity in hippocampal CA I area after short-term (10 min) oxygen-glucose deprivation (OGD) followed by reoxygenation during 1 h. The experiments were carried out on hippocampal slice cultures.	oxygen-glucose	140-154	carbonic anhydrase 1	Homo sapiens	104-108
18773881-0	2008	Mutated IkappaBalpha represses proliferation of immortalized neural progenitor cells and prevents their apoptosis after oxygen-glucose deprivation.	oxygen-glucose	120-134	NFKB inhibitor alpha	Homo sapiens	8-20
18773881-12	2008	NF-kappaB activity down-regulation represses proliferation of INPCs and improves their tolerance to oxygen-glucose deprivation.	oxygen-glucose	100-114	nuclear factor kappa B subunit 1	Homo sapiens	0-9
18638472-0	2008	Anti-inflammatory treatment with the p38 mitogen-activated protein kinase inhibitor SB239063 is neuroprotective, decreases the number of activated microglia and facilitates neurogenesis in oxygen-glucose-deprived hippocampal slice cultures.	oxygen-glucose	189-203	mitogen-activated protein kinase 1	Homo sapiens	37-40
18638472-2	2008	Our study shows that after oxygen-glucose deprivation, the p38 mitogen-activated protein kinase (MAPK) and the extracellular-signal-regulated kinase 1/2 (ERK1/2) are strongly activated.	oxygen-glucose	27-41	mitogen-activated protein kinase 14	Homo sapiens	59-95
18638472-2	2008	Our study shows that after oxygen-glucose deprivation, the p38 mitogen-activated protein kinase (MAPK) and the extracellular-signal-regulated kinase 1/2 (ERK1/2) are strongly activated.	oxygen-glucose	27-41	mitogen-activated protein kinase 3	Homo sapiens	97-101
18638472-2	2008	Our study shows that after oxygen-glucose deprivation, the p38 mitogen-activated protein kinase (MAPK) and the extracellular-signal-regulated kinase 1/2 (ERK1/2) are strongly activated.	oxygen-glucose	27-41	mitogen-activated protein kinase 1	Homo sapiens	111-152
18638472-2	2008	Our study shows that after oxygen-glucose deprivation, the p38 mitogen-activated protein kinase (MAPK) and the extracellular-signal-regulated kinase 1/2 (ERK1/2) are strongly activated.	oxygen-glucose	27-41	mitogen-activated protein kinase 3	Homo sapiens	154-160
19129402-7	2009	MCP-1 significantly reduced lactate dehydrogenase release from neurons after oxygen-glucose deprivation (OGD) and prevented the loss of ATP levels that occurred after OGD or treatment with glutamate.	oxygen-glucose	77-91	C-C motif chemokine ligand 2	Homo sapiens	0-5
19082428-0	2008	[Overexpression of PDZ1 domain of PSD-95 protein rescues hippocampal neurons from apoptosis induced by oxygen-glucose deprivation].	oxygen-glucose	103-117	DLG associated protein 2	Rattus norvegicus	34-40
18706478-0	2008	Inhibition of PKCgamma membrane translocation mediated morphine preconditioning-induced neuroprotection against oxygen-glucose deprivation in the hippocampus slices of mice.	oxygen-glucose	112-126	protein kinase C, gamma	Mus musculus	14-22
18575457-7	2008	We observed early IL-1beta expression in astrocytes in vivo after MCAo and after oxygen-glucose deprivation in vitro, which might contribute to the ischemic damage.	oxygen-glucose	81-95	interleukin 1 beta	Mus musculus	18-26
18203692-1	2008	We have recently found that in the mouse cortex, activation of delta-opioid receptor (DOR) attenuates the disruption of K(+) homeostasis induced by hypoxia or oxygen-glucose deprivation.	oxygen-glucose	159-173	opioid receptor, delta 1	Mus musculus	86-89
18471812-8	2008	Protection afforded by NP00111 and rosiglitazone were prevented by the PPARgamma antagonist GW9662, suggesting that both NP00111 and rosiglitazone were preventing cell death caused by oxygen-glucose deprivation via activation of PPARgamma.	oxygen-glucose	184-198	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	71-80
18668152-4	2008	Oxygen-glucose-serum deprivation and blockage of P2Y(1) receptor caused elevation of phosphorylated Akt and cAMP response element binding protein (CREB), and reduction of phosphorylated Janus kinase2 (JAK2) and signal transducer and activator of transcription3 (STAT3, Ser727).	oxygen-glucose	0-14	AKT serine/threonine kinase 1	Homo sapiens	100-103
18668152-4	2008	Oxygen-glucose-serum deprivation and blockage of P2Y(1) receptor caused elevation of phosphorylated Akt and cAMP response element binding protein (CREB), and reduction of phosphorylated Janus kinase2 (JAK2) and signal transducer and activator of transcription3 (STAT3, Ser727).	oxygen-glucose	0-14	cAMP responsive element binding protein 1	Homo sapiens	108-145
18668152-4	2008	Oxygen-glucose-serum deprivation and blockage of P2Y(1) receptor caused elevation of phosphorylated Akt and cAMP response element binding protein (CREB), and reduction of phosphorylated Janus kinase2 (JAK2) and signal transducer and activator of transcription3 (STAT3, Ser727).	oxygen-glucose	0-14	cAMP responsive element binding protein 1	Homo sapiens	147-151
18668152-4	2008	Oxygen-glucose-serum deprivation and blockage of P2Y(1) receptor caused elevation of phosphorylated Akt and cAMP response element binding protein (CREB), and reduction of phosphorylated Janus kinase2 (JAK2) and signal transducer and activator of transcription3 (STAT3, Ser727).	oxygen-glucose	0-14	Janus kinase 2	Homo sapiens	186-199
18668152-4	2008	Oxygen-glucose-serum deprivation and blockage of P2Y(1) receptor caused elevation of phosphorylated Akt and cAMP response element binding protein (CREB), and reduction of phosphorylated Janus kinase2 (JAK2) and signal transducer and activator of transcription3 (STAT3, Ser727).	oxygen-glucose	0-14	Janus kinase 2	Homo sapiens	201-205
18668152-4	2008	Oxygen-glucose-serum deprivation and blockage of P2Y(1) receptor caused elevation of phosphorylated Akt and cAMP response element binding protein (CREB), and reduction of phosphorylated Janus kinase2 (JAK2) and signal transducer and activator of transcription3 (STAT3, Ser727).	oxygen-glucose	0-14	signal transducer and activator of transcription 3	Homo sapiens	211-260
18668152-4	2008	Oxygen-glucose-serum deprivation and blockage of P2Y(1) receptor caused elevation of phosphorylated Akt and cAMP response element binding protein (CREB), and reduction of phosphorylated Janus kinase2 (JAK2) and signal transducer and activator of transcription3 (STAT3, Ser727).	oxygen-glucose	0-14	signal transducer and activator of transcription 3	Homo sapiens	262-267
18398416-0	2008	Preconditioning mediated by sublethal oxygen-glucose deprivation-induced cyclooxygenase-2 expression via the signal transducers and activators of transcription 3 phosphorylation.	oxygen-glucose	38-52	prostaglandin-endoperoxide synthase 2	Homo sapiens	73-89
18425312-0	2008	[Protection of hepatocyte growth factor on neurons subjected to oxygen-glucose deprivation/reperfusion].	oxygen-glucose	64-78	hepatocyte growth factor	Rattus norvegicus	15-39
18363826-2	2008	The current studies show that these events lead to the release of the protein hydrolase, cathepsin B, from lysosomes 2 h following 5-min oxygen-glucose deprivation in the rat hippocampal slice.	oxygen-glucose	137-151	cathepsin B	Rattus norvegicus	89-100
18413601-7	2008	Also, EPO- and VEGF-induced neuroprotection against GD, oxygen-glucose deprivation, and NMDA excitotoxicity depended significantly on TNFRI presence.	oxygen-glucose	56-70	erythropoietin	Mus musculus	6-9
18413601-7	2008	Also, EPO- and VEGF-induced neuroprotection against GD, oxygen-glucose deprivation, and NMDA excitotoxicity depended significantly on TNFRI presence.	oxygen-glucose	56-70	vascular endothelial growth factor A	Mus musculus	15-19
18413601-7	2008	Also, EPO- and VEGF-induced neuroprotection against GD, oxygen-glucose deprivation, and NMDA excitotoxicity depended significantly on TNFRI presence.	oxygen-glucose	56-70	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	134-139
18425312-1	2008	The present study was conducted to investigate the effect of hepatocyte growth factor (HGF) on cortical neurons exposed to oxygen-glucose deprivation/reperfusion (OGD/R).	oxygen-glucose	123-137	hepatocyte growth factor	Rattus norvegicus	61-85
18425312-1	2008	The present study was conducted to investigate the effect of hepatocyte growth factor (HGF) on cortical neurons exposed to oxygen-glucose deprivation/reperfusion (OGD/R).	oxygen-glucose	123-137	hepatocyte growth factor	Rattus norvegicus	87-90
18030304-2	2008	Here, the impact of experimental ischemia (oxygen-glucose deprivation (OGD)) on dystroglycan expression by murine endothelial cells and astrocytes grown on vascular matrix laminin, perlecan, or collagen and the impact of middle cerebral artery occlusion on alphabeta-dystroglycan within cerebral microvessels of the nonhuman primate were examined.	oxygen-glucose	43-57	dystroglycan 1	Mus musculus	80-92
18206124-3	2008	By using acute hippocampal slices and the fluorescent dye CM-H2DCFDA, we showed that reoxygenation after in vitro ischemia (oxygen-glucose deprivation; OGD) increased ROS levels in the hippocampal CA1 layers vulnerable to ischemia but did not have significant effects in the resistant stratum granulosum in the dentate gyrus (DG).	oxygen-glucose	124-138	carbonic anhydrase 1	Homo sapiens	197-200
17339844-3	2007	KEY RESULTS: Here, we show that preservation of ECs by EPO during oxygen-glucose deprivation (OGD) required the initial activation of the phosphatidylinositol 3-kinase (PI-3K) pathway through Akt1, since specific pharmacological blockade of Akt1 activity or gene silencing of Akt1 prevented EC protection by EPO.	oxygen-glucose	66-80	erythropoietin	Homo sapiens	55-58
18032737-6	2008	Oxygen-glucose deprivation produced a further significant increase in subunit beta1 expression by both cell types, but a clear decrease in both alpha1 and alpha 6 subunits by murine astrocytes.	oxygen-glucose	0-14	hemoglobin, beta adult major chain	Mus musculus	78-83
17942394-5	2007	Up-regulation of RAGE expression was also observed in primary neurons subjected to hypoxia or oxygen-glucose deprivation, an in vitro model of ischemia.	oxygen-glucose	94-108	advanced glycosylation end product-specific receptor	Mus musculus	17-21
17942394-6	2007	Treatment of neurons with low concentrations of S100B decreased neuronal death after oxygen-glucose deprivation, and this effect was abolished by a neutralizing antibody against RAGE.	oxygen-glucose	85-99	S100 protein, beta polypeptide, neural	Mus musculus	48-53
17942394-6	2007	Treatment of neurons with low concentrations of S100B decreased neuronal death after oxygen-glucose deprivation, and this effect was abolished by a neutralizing antibody against RAGE.	oxygen-glucose	85-99	advanced glycosylation end product-specific receptor	Mus musculus	178-182
17728442-4	2007	In this study, we identified calpain I as a direct activator of AIF release in neuronal cultures challenged with oxygen-glucose deprivation and in the rat model of transient global ischemia.	oxygen-glucose	113-127	apoptosis inducing factor, mitochondria associated 1	Rattus norvegicus	64-67
17728442-6	2007	The truncation of AIF by calpain activity appeared to be essential for its translocation from mitochondria to the nucleus, because neuronal transfection of the mutant AIF resistant to calpain cleavage was not released after oxygen-glucose deprivation.	oxygen-glucose	224-238	apoptosis inducing factor, mitochondria associated 1	Rattus norvegicus	18-21
17728442-6	2007	The truncation of AIF by calpain activity appeared to be essential for its translocation from mitochondria to the nucleus, because neuronal transfection of the mutant AIF resistant to calpain cleavage was not released after oxygen-glucose deprivation.	oxygen-glucose	224-238	apoptosis inducing factor, mitochondria associated 1	Rattus norvegicus	167-170
17600230-0	2007	Neuroprotective effects of leptin against ischemic injury induced by oxygen-glucose deprivation and transient cerebral ischemia.	oxygen-glucose	69-83	leptin	Mus musculus	27-33
17600230-7	2007	In vitro results showed that leptin, 50 to 100 mug/mL, protected primary cortical neurons against death induced by oxygen-glucose deprivation in a concentration-dependent manner.	oxygen-glucose	115-129	leptin	Mus musculus	29-35
18007082-0	2007	[Protective effect of thrombin precondition on astrocytes insulted by oxygen-glucose deprivation].	oxygen-glucose	70-84	coagulation factor II	Rattus norvegicus	22-30
18007082-1	2007	OBJECTIVE: To explore the effect of thrombin precondition (TPC) on the rat cerebral astrocytes(As) cultured in oxygen-glucose deprivation (OGD).	oxygen-glucose	111-125	coagulation factor II	Rattus norvegicus	36-44
16435392-2	2006	We induced EPO preconditioning in cortical neuronal cultures that protected neurons from a subsequent in vitro ischemic insult (transient oxygen-glucose deprivation).	oxygen-glucose	138-152	erythropoietin	Rattus norvegicus	11-14
17178835-6	2007	An NRP-1 selective peptide inhibitor provided neuroprotection against oxygen-glucose deprivation.	oxygen-glucose	70-84	neuropilin 1	Mus musculus	3-8
16570076-0	2006	Promoter region methylation and reduced expression of thrombospondin-1 after oxygen-glucose deprivation in murine cerebral endothelial cells.	oxygen-glucose	77-91	thrombospondin 1	Mus musculus	54-70
16570076-7	2006	The present study aimed to explore whether methylation of the promoter region of TSP-1 regulates its expression after oxygen-glucose deprivation (OGD) in murine cerebral endothelial cells (CECs) in vitro.	oxygen-glucose	118-132	thrombospondin 1	Mus musculus	81-86
16570076-11	2006	Oxygen-glucose deprivation-induced reduction in the TSP-1 mRNA level was not accompanied by a change in mRNA stability.	oxygen-glucose	0-14	thrombospondin 1	Mus musculus	52-57
16735028-5	2006	In primary cardiomyocytes, the simulated IP procedure, incubation in oxygen-glucose deprivation (OGD) medium, also increased the GRP78 expression and suppressed the cell death caused by lethal ischemia.	oxygen-glucose	69-83	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	129-134
16814750-7	2006	To mimic the ischemia-reperfusion injury in experimental animals, we employed hippocampal slice cultures that were first treated with oxygen and glucose deprivation (OGD) and then with oxygen-glucose resupply, finding that fibronectin significantly increased the neurite outgrowth of OGD hippocampal slices, upregulated the expression of Bcl-2 protein, and ameliorated the ultrastructure damage of OGD hippocampal slices.	oxygen-glucose	185-199	fibronectin 1	Rattus norvegicus	223-234
16563639-5	2006	This release could be blocked by the selective inhibitor of the Ca2+-independent phospholipase A2, 4-bromoenol lactone (10 microM), when it was added 30 min prior to oxygen-glucose deprivation.	oxygen-glucose	166-180	carbonic anhydrase 2	Rattus norvegicus	64-67
16563639-5	2006	This release could be blocked by the selective inhibitor of the Ca2+-independent phospholipase A2, 4-bromoenol lactone (10 microM), when it was added 30 min prior to oxygen-glucose deprivation.	oxygen-glucose	166-180	phospholipase A2 group IB	Rattus norvegicus	81-97
16563639-13	2006	Simultaneous inhibition of Ca2+-independent and Ca2+-dependent phospholipases A2 by treatment with the general phospholipase A2 inhibitor methyl arachidonyl fluorophosphonate (3 microM, 30 min prior to oxygen-glucose deprivation) resulted in significant enhancement of the neuroprotective effect in the dentate gyrus, but not in the CA1 and CA3 areas.	oxygen-glucose	202-216	carbonic anhydrase 2	Rattus norvegicus	27-30
17035299-1	2007	Na(+)-K(+)-Cl(-) cotransporter isoform 1 (NKCC1) and reverse mode operation of the Na(+)/Ca(2+) exchanger (NCX) contribute to intracellular Na(+) and Ca(2+) overload in astrocytes following oxygen-glucose deprivation (OGD) and reoxygenation (REOX).	oxygen-glucose	190-204	solute carrier family 12 member 2	Homo sapiens	42-47
17035299-1	2007	Na(+)-K(+)-Cl(-) cotransporter isoform 1 (NKCC1) and reverse mode operation of the Na(+)/Ca(2+) exchanger (NCX) contribute to intracellular Na(+) and Ca(2+) overload in astrocytes following oxygen-glucose deprivation (OGD) and reoxygenation (REOX).	oxygen-glucose	190-204	solute carrier family 8 member A1	Homo sapiens	83-105
17035299-1	2007	Na(+)-K(+)-Cl(-) cotransporter isoform 1 (NKCC1) and reverse mode operation of the Na(+)/Ca(2+) exchanger (NCX) contribute to intracellular Na(+) and Ca(2+) overload in astrocytes following oxygen-glucose deprivation (OGD) and reoxygenation (REOX).	oxygen-glucose	190-204	T cell leukemia homeobox 2	Homo sapiens	107-110
16563639-0	2006	Neuroprotection of rat hippocampal slices exposed to oxygen-glucose deprivation by enrichment with docosahexaenoic acid and by inhibition of hydrolysis of docosahexaenoic acid-containing phospholipids by calcium independent phospholipase A2.	oxygen-glucose	53-67	phospholipase A2 group IB	Rattus norvegicus	224-240
16707783-3	2006	Here we show that brief oxygen-glucose deprivation (OGD), an in vitro model of brain ischemia, promotes redistribution of AMPARs at synapses of hippocampal neurons, leading to a switch in AMPAR subunit composition.	oxygen-glucose	24-38	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	122-128
16817862-3	2006	Using an in vitro oxygen-glucose deprivation (OGD) model of ischemia, we found that N-methyl-D-aspartate (NMDA) responses were enhanced in the more susceptible CA1 pyramidal cells and transiently depressed in the resistant CA3 pyramidal cells.	oxygen-glucose	18-32	carbonic anhydrase 1	Homo sapiens	160-163
16606359-0	2006	Activation of 5-lipoxygenase after oxygen-glucose deprivation is partly mediated via NMDA receptor in rat cortical neurons.	oxygen-glucose	35-49	arachidonate 5-lipoxygenase	Rattus norvegicus	14-28
16606359-3	2006	In the present study, we determined whether 5-LOX is activated (translocation and production of leukotrienes) after oxygen-glucose deprivation (OGD) in primary rat cortical neurons; if so, whether this activation is mediated by NMDA receptor.	oxygen-glucose	116-130	lysyl oxidase	Rattus norvegicus	46-49
16369784-0	2006	Long-term potentiation of evoked presynaptic response at CA3-CA1 synapses by transient oxygen-glucose deprivation in rat brain slices.	oxygen-glucose	87-101	carbonic anhydrase 3	Rattus norvegicus	57-64
16369784-5	2006	Here we show that a short period of oxygen-glucose deprivation can induce a form of LTP (lasting for hours) of the presynaptic response at the CA3-CA1 synapses.	oxygen-glucose	36-50	carbonic anhydrase 3	Rattus norvegicus	143-150
16289353-8	2006	During oxygen-glucose deprivation, it was able to reverse the oxygen-glucose deprivation-induced increase in extracellular glutamate and decrease in glutamate uptake and this effect was reversed in the presence of threo-3-methyl glutamate, a specific inhibitor of glutamate transporter-1.	oxygen-glucose	7-21	solute carrier family 1 member 2	Rattus norvegicus	264-287
16394694-4	2006	To investigate its possible mechanism of action, the authors then examined whether propofol could reduce Ca2+-induced rat brain mitochondrial swelling, an index of mitochondrial membrane permeability, as well as the mitochondrial swelling evoked by oxygen-glucose deprivation in CA1 pyramidal cells by transmission electron microscopy.	oxygen-glucose	249-263	carbonic anhydrase 1	Rattus norvegicus	279-282
16394694-7	2006	Ca2+-induced brain mitochondrial swelling was prevented by 30-100 microM propofol, and so were the ultrastructural mitochondrial changes in CA1 pyramidal cells exposed to oxygen-glucose deprivation.	oxygen-glucose	171-185	carbonic anhydrase 2	Rattus norvegicus	0-3
16394694-7	2006	Ca2+-induced brain mitochondrial swelling was prevented by 30-100 microM propofol, and so were the ultrastructural mitochondrial changes in CA1 pyramidal cells exposed to oxygen-glucose deprivation.	oxygen-glucose	171-185	carbonic anhydrase 1	Rattus norvegicus	140-143
16289353-8	2006	During oxygen-glucose deprivation, it was able to reverse the oxygen-glucose deprivation-induced increase in extracellular glutamate and decrease in glutamate uptake and this effect was reversed in the presence of threo-3-methyl glutamate, a specific inhibitor of glutamate transporter-1.	oxygen-glucose	62-76	solute carrier family 1 member 2	Rattus norvegicus	264-287
15964567-3	2005	Inhibition of cyclooxygenase-2 protects cortical neuronal cultures from death induced by oxygen-glucose deprivation and reduces oxygen-glucose deprivation-induced increases in intracellular Ca(2+) ([Ca(2+)](i)).	oxygen-glucose	89-103	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	14-30
16267234-0	2005	Apoptosis-inducing factor triggered by poly(ADP-ribose) polymerase and Bid mediates neuronal cell death after oxygen-glucose deprivation and focal cerebral ischemia.	oxygen-glucose	110-124	apoptosis-inducing factor, mitochondrion-associated 1	Mus musculus	0-25
16267234-0	2005	Apoptosis-inducing factor triggered by poly(ADP-ribose) polymerase and Bid mediates neuronal cell death after oxygen-glucose deprivation and focal cerebral ischemia.	oxygen-glucose	110-124	poly (ADP-ribose) polymerase family, member 1	Mus musculus	39-66
16267234-0	2005	Apoptosis-inducing factor triggered by poly(ADP-ribose) polymerase and Bid mediates neuronal cell death after oxygen-glucose deprivation and focal cerebral ischemia.	oxygen-glucose	110-124	BH3 interacting domain death agonist	Mus musculus	71-74
16267234-2	2005	In the present study, we investigated whether apoptosis-inducing factor (AIF), a caspase-independent proapoptotic protein, is responsible for neuronal cell death after glutamate toxicity and oxygen-glucose deprivation (OGD) in vitro and after experimental stroke in vivo.	oxygen-glucose	191-205	apoptosis-inducing factor, mitochondrion-associated 1	Mus musculus	46-71
16267234-2	2005	In the present study, we investigated whether apoptosis-inducing factor (AIF), a caspase-independent proapoptotic protein, is responsible for neuronal cell death after glutamate toxicity and oxygen-glucose deprivation (OGD) in vitro and after experimental stroke in vivo.	oxygen-glucose	191-205	apoptosis-inducing factor, mitochondrion-associated 1	Mus musculus	73-76
15964567-7	2005	These effects likely occur via activation of the prostanoid EP(1) receptor since blocking this receptor during oxygen-glucose deprivation reduced [Ca(2+)](i) and neurotoxicity.	oxygen-glucose	111-125	prostaglandin E receptor 1	Rattus norvegicus	49-74
15964567-10	2005	Furthermore, cultures were rendered tolerant to oxygen-glucose deprivation by the transient exposure to exogenous PGE(2) 24 h prior to the insult, indicating that this product of the cyclooxygenase-2 pathway is sufficient to induce ischemic tolerance.	oxygen-glucose	48-62	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	183-199
15964567-11	2005	This study shows that cyclooxygenase-2 and PGE(2) are involved in both oxygen-glucose deprivation-induced neurotoxicity and preconditioning-induced neuroprotection.	oxygen-glucose	71-85	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	22-38
15964567-3	2005	Inhibition of cyclooxygenase-2 protects cortical neuronal cultures from death induced by oxygen-glucose deprivation and reduces oxygen-glucose deprivation-induced increases in intracellular Ca(2+) ([Ca(2+)](i)).	oxygen-glucose	128-142	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	14-30
15816858-3	2005	We investigated the involvement of oxidative stress and expression of APE in neurons after oxygen-glucose deprivation and after global cerebral ischemia.	oxygen-glucose	91-105	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	70-73
15606900-0	2005	Insulin exerts neuroprotection by counteracting the decrease in cell-surface GABA receptors following oxygen-glucose deprivation in cultured cortical neurons.	oxygen-glucose	102-116	insulin	Homo sapiens	0-7
15678112-12	2005	Oxygen-glucose deprivation (OGD) induced approximately 67% cell death and a fourfold increase in Na+ accumulation in cultured NKCC1(+/+) cortical neurons.	oxygen-glucose	0-14	solute carrier family 12, member 2	Mus musculus	126-131
16344151-9	2005	Our experimental studies on oxygen-glucose deprivation confirmed that CA1 pyramidal cells were the most susceptible to this ischemia-like condition.	oxygen-glucose	28-42	carbonic anhydrase 1	Rattus norvegicus	70-73
16344151-11	2005	Nuclear chromatin staining by Hoechst 33342 and staining for active caspase-3 showed that oxygen-glucose deprivation induced necrotic cell death only.	oxygen-glucose	90-104	caspase 3	Rattus norvegicus	68-77
16344151-19	2005	As a logical, but in some glial cell-line derived neurotrophic factor therapy-related conditions clearly unwanted consequence the susceptibility for oxygen-glucose deprivation-induced glutamate receptor-mediated cell death is increased after glial cell-line derived neurotrophic factor treatment.	oxygen-glucose	149-163	glial cell derived neurotrophic factor	Rattus norvegicus	26-69
16344151-19	2005	As a logical, but in some glial cell-line derived neurotrophic factor therapy-related conditions clearly unwanted consequence the susceptibility for oxygen-glucose deprivation-induced glutamate receptor-mediated cell death is increased after glial cell-line derived neurotrophic factor treatment.	oxygen-glucose	149-163	glial cell derived neurotrophic factor	Rattus norvegicus	242-285
15579199-0	2004	Neurotrophin and Trk expression by cells of the human lamina cribrosa following oxygen-glucose deprivation.	oxygen-glucose	80-94	brain derived neurotrophic factor	Homo sapiens	0-12
15579199-0	2004	Neurotrophin and Trk expression by cells of the human lamina cribrosa following oxygen-glucose deprivation.	oxygen-glucose	80-94	neurotrophic receptor tyrosine kinase 1	Homo sapiens	17-20
15009686-7	2004	Erythro-9-(2-hydroxy-3-nonyl)adenine, an inhibitor of adenosine deaminase, reduced neuronal inosine release evoked by oxygen-glucose deprivation but not by 2-deoxyglucose treatment.	oxygen-glucose	118-132	adenosine deaminase	Rattus norvegicus	54-73
15519743-0	2004	Corticotropin-releasing hormone potentiates neural injury induced by oxygen-glucose deprivation: a possible involvement of microglia.	oxygen-glucose	69-83	corticotropin releasing hormone	Homo sapiens	0-31
15519743-2	2004	In the present study, we have determined the effect of CRH on oxygen-glucose deprivation (OGD) induced apoptosis in fetal hippocampal neurons.	oxygen-glucose	62-76	corticotropin releasing hormone	Homo sapiens	55-58
15473983-0	2004	Enhanced release of synaptic glutamate underlies the potentiation of oxygen-glucose deprivation-induced neuronal injury after induction of NOS-2.	oxygen-glucose	69-83	nitric oxide synthase 2, inducible	Mus musculus	139-144
15473983-2	2004	Consistent with this, induction of nitric oxide synthase (NOS-2) in murine neocortical cell cultures potentiated neuronal cell death caused by combined oxygen-glucose deprivation in association with a net increase in extracellular glutamate accumulation.	oxygen-glucose	152-166	nitric oxide synthase 2, inducible	Mus musculus	58-63
15194624-0	2004	Thiopental and isoflurane attenuate the decrease in hippocampal phosphorylated Focal Adhesion Kinase (pp125FAK) content induced by oxygen-glucose deprivation.	oxygen-glucose	131-145	protein tyrosine kinase 2	Homo sapiens	102-110
15194624-11	2004	CONCLUSION: Phosphorylated pp125FAK content was markedly decreased in hippocampal slices subjected to oxygen-glucose deprivation.	oxygen-glucose	102-116	protein tyrosine kinase 2	Homo sapiens	27-35
15246837-0	2004	Glycogen synthase kinase 3beta inhibitor Chir025 reduces neuronal death resulting from oxygen-glucose deprivation, glutamate excitotoxicity, and cerebral ischemia.	oxygen-glucose	87-101	glycogen synthase kinase 3 beta	Rattus norvegicus	0-30
15196687-2	2004	To investigate the mechanisms by which developing animals exhibit ischemic resistance, we examined the changes in intracellular calcium ([Ca2+]i) after oxygen-glucose deprivation (OGD) using hippocampal slices from gerbils.	oxygen-glucose	152-166	carbonic anhydrase 2	Homo sapiens	138-141
15158018-0	2004	Ischemic preconditioning decreases intracellular zinc accumulation induced by oxygen-glucose deprivation in gerbil hippocampal CA1 neurons.	oxygen-glucose	78-92	carbonic anhydrase 1	Homo sapiens	127-130
15158018-3	2004	In normal slices, large increases in [Zn2+]i and [Ca2+]i were observed in the stratum radiatum of the CA1 area after oxygen-glucose deprivation.	oxygen-glucose	117-131	carbonic anhydrase 2	Homo sapiens	50-53
15158018-3	2004	In normal slices, large increases in [Zn2+]i and [Ca2+]i were observed in the stratum radiatum of the CA1 area after oxygen-glucose deprivation.	oxygen-glucose	117-131	carbonic anhydrase 1	Homo sapiens	102-105
15128862-8	2004	However, oxygen-glucose deprivation caused a progressive downregulation of the K+-Cl- cotransporter (KCC2), which may have contributed to the Cl- accumulation.	oxygen-glucose	9-23	solute carrier family 12 member 5	Rattus norvegicus	101-105
21158113-2	2004	METHODS: The gene expression of HIF-1alpha pretreated with or without Gin (37.5 microg/ml) was observed by RT-PCR on primary cultured cortical neurons in the condition of hypoxia and oxygen-glucose deprivation.	oxygen-glucose	183-197	hypoxia inducible factor 1 subunit alpha	Homo sapiens	32-42
15189763-0	2004	Opposing effects of cyclooxygenase-2 selective inhibitors on oxygen-glucose deprivation-induced neurotoxicity.	oxygen-glucose	61-75	prostaglandin-endoperoxide synthase 2	Homo sapiens	20-36
15189763-3	2004	Oxygen-glucose deprivation (OGD) induced cyclooxygenase-2 protein expression in neuronal cortical cultures.	oxygen-glucose	0-14	prostaglandin-endoperoxide synthase 2	Homo sapiens	41-57
12210785-8	2002	In injured (oxygen-glucose deprivation) hippocampal neuron cultures, HSP72 vector transfection led to 2.8 times as much Bcl-2 expression as control vector.	oxygen-glucose	12-26	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	69-74
14705148-7	2004	We showed that thrombin can be neuroprotective or deleterious when present at different concentrations before and during oxygen-glucose deprivation, an in vitro model of ischemia.	oxygen-glucose	121-135	coagulation factor II	Rattus norvegicus	15-23
14526224-0	2003	Translocation of apoptosis-inducing factor in vulnerable neurons after transient cerebral ischemia and in neuronal cultures after oxygen-glucose deprivation.	oxygen-glucose	130-144	apoptosis inducing factor, mitochondria associated 1	Rattus norvegicus	17-42
12364740-3	2002	We investigated the potential interaction of ATM and NF-kappaB after oxygen-glucose deprivation (OGD) in cerebral endothelial cells (CECs).	oxygen-glucose	69-83	ataxia telangiectasia mutated	Mus musculus	45-48
12834896-0	2003	Microtubule-associated protein 2 (MAP2) associates with the NMDA receptor and is spatially redistributed within rat hippocampal neurons after oxygen-glucose deprivation.	oxygen-glucose	142-156	microtubule-associated protein 2	Rattus norvegicus	0-32
12834896-0	2003	Microtubule-associated protein 2 (MAP2) associates with the NMDA receptor and is spatially redistributed within rat hippocampal neurons after oxygen-glucose deprivation.	oxygen-glucose	142-156	microtubule-associated protein 2	Rattus norvegicus	34-38
12834896-3	2003	This study determined that MAP2 resides in a complex with the NMDA receptor, suggesting that spatially localized changes may be important in the mechanism of MAP2 redistribution and breakdown after oxygen-glucose deprivation (OGD).	oxygen-glucose	198-212	microtubule-associated protein 2	Rattus norvegicus	27-31
12834896-3	2003	This study determined that MAP2 resides in a complex with the NMDA receptor, suggesting that spatially localized changes may be important in the mechanism of MAP2 redistribution and breakdown after oxygen-glucose deprivation (OGD).	oxygen-glucose	198-212	microtubule-associated protein 2	Rattus norvegicus	158-162
12603827-3	2003	In primary cultures of rat cortex the activity of NQO1 was measured after treatment with ethylcholine aziridinium (AF64A; 40 micro m), inducing mainly apoptotic cell death, or oxygen-glucose deprivation (OGD; 120 min), which combines features of apoptotic and necrotic cell death.	oxygen-glucose	176-190	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	50-54
12468005-6	2002	Moreover, we show that RNAi-mediated inhibition of poly (ADP-ribose) polymerase (PARP) expression induced cellular resistance to oxygen-glucose deprivation, consistent with the role of PARP in ischemia-induced brain damage.	oxygen-glucose	129-143	poly(ADP-ribose) polymerase 1	Homo sapiens	51-79
12468005-6	2002	Moreover, we show that RNAi-mediated inhibition of poly (ADP-ribose) polymerase (PARP) expression induced cellular resistance to oxygen-glucose deprivation, consistent with the role of PARP in ischemia-induced brain damage.	oxygen-glucose	129-143	poly(ADP-ribose) polymerase 1	Homo sapiens	81-85
11893922-3	2002	In vitro Ca2+ imaging studies using hippocampal slices revealed that oxygen-glucose deprivation induced a [Ca2+]i increase in the hippocampal CA1 region more vigorously in Ca(v)2.3 mutant mice than in wild-type controls, and that tetrodotoxin or bicuculline application abolished the difference between the genotypes.	oxygen-glucose	69-83	carbonic anhydrase 1	Mus musculus	142-145
12213266-3	2002	In rat organotypic hippocampal slices exposed to oxygen-glucose deprivation, the mGlu1 antagonists AIDA, CBPG and 3-MATIDA reduced CA1 pyramidal cell loss when added to the medium during the insult and the subsequent recovery period.	oxygen-glucose	49-63	axin interactor, dorsalization associated	Rattus norvegicus	99-103
11893922-3	2002	In vitro Ca2+ imaging studies using hippocampal slices revealed that oxygen-glucose deprivation induced a [Ca2+]i increase in the hippocampal CA1 region more vigorously in Ca(v)2.3 mutant mice than in wild-type controls, and that tetrodotoxin or bicuculline application abolished the difference between the genotypes.	oxygen-glucose	69-83	calcium channel, voltage-dependent, R type, alpha 1E subunit	Mus musculus	172-180
11796196-9	2002	We conclude that AdoMet exerts citoprotective effects in an experimental model of brain slices reoxygenation after oxygen-glucose deprivation.	oxygen-glucose	115-129	methionine adenosyltransferase 1A	Rattus norvegicus	17-23
11848682-0	2002	Neurotrophin-3 promotes cell death induced in cerebral ischemia, oxygen-glucose deprivation, and oxidative stress: possible involvement of oxygen free radicals.	oxygen-glucose	65-79	neurotrophin 3	Homo sapiens	0-14
11848682-5	2002	Consistent with this, the addition of NT-3 to primary cortical cell cultures exacerbated neuronal death caused by oxygen-glucose deprivation.	oxygen-glucose	114-128	neurotrophin 3	Homo sapiens	38-42
11556885-9	2001	After exposing hippocampal slice cultures to a severe experimental ischemia (oxygen-glucose deprivation), the expression of PARs 1-3 was up-regulated with subtype-specific kinetics.	oxygen-glucose	77-91	coagulation factor II (thrombin) receptor	Rattus norvegicus	124-132
11640926-4	2001	This type of vital imaging provides direct evidence of dendritic rearrangements in rat CA1 pyramidal neurons occurring as soon as 20 min after oxygen-glucose deprivation.	oxygen-glucose	143-157	carbonic anhydrase 1	Rattus norvegicus	87-90
11702043-0	2001	Concurrent assessment of calpain and caspase-3 activation after oxygen-glucose deprivation in primary septo-hippocampal cultures.	oxygen-glucose	64-78	caspase 3	Homo sapiens	37-46
11526447-3	2001	Increasing concentrations of the three PARP inhibitors attenuated neuronal injury induced by 60 min oxygen-glucose deprivation (OGD) in mixed cortical cell cultures, but were unable to reduce CA1 pyramidal cell loss in organotypic hippocampal slices exposed to 30 min OGD or in gerbils following 5 min bilateral carotid occlusion.	oxygen-glucose	100-114	poly(ADP-ribose) polymerase 1	Homo sapiens	39-43
11464212-9	2001	Inhibition of both TNF and CD95L in vitro prevented death of primary neurons induced by oxygen-glucose deprivation and reperfusion.	oxygen-glucose	88-102	tumor necrosis factor	Mus musculus	19-22
11438580-4	2001	Loss of p27(Kip1), another Cdk inhibitor, precedes cell death in neocortical neurons subjected to oxygen-glucose deprivation in vitro.	oxygen-glucose	98-112	interferon alpha inducible protein 27	Homo sapiens	8-11
11438580-4	2001	Loss of p27(Kip1), another Cdk inhibitor, precedes cell death in neocortical neurons subjected to oxygen-glucose deprivation in vitro.	oxygen-glucose	98-112	cyclin dependent kinase inhibitor 1B	Homo sapiens	12-16
11464212-9	2001	Inhibition of both TNF and CD95L in vitro prevented death of primary neurons induced by oxygen-glucose deprivation and reperfusion.	oxygen-glucose	88-102	Fas ligand (TNF superfamily, member 6)	Mus musculus	27-32
10884482-4	2000	This study aimed to characterize bovine cerebral EC death in relation to iNOS expression after oxygen-glucose deprivation (OGD) in vitro.	oxygen-glucose	95-109	nitric oxide synthase 2	Bos taurus	73-77
11461967-2	2001	We demonstrate E2F1 involvement in neuronal death induced by the more physiological oxygen-glucose deprivation (OGD) in mouse cortical cultures and by anoxia in mouse hippocampal slices.	oxygen-glucose	84-98	E2F transcription factor 1	Mus musculus	15-19
11488532-0	2001	Tissue-type plasminogen activator is involved in the process of neuronal death induced by oxygen-glucose deprivation in culture.	oxygen-glucose	90-104	plasminogen activator, tissue	Mus musculus	0-33
11488532-1	2001	Effect of tissue-type plasminogen activator (tPA) on oxygen-glucose deprivation (OGD) was studied in cultured cortical neurons prepared from tPA gene knockout (tPA-KO) and wild-type (Wt) mice.	oxygen-glucose	53-67	plasminogen activator, tissue	Mus musculus	45-48
11161606-0	2001	Calcitonin potentiates oxygen-glucose deprivation-induced neuronal death.	oxygen-glucose	23-37	calcitonin related polypeptide alpha	Homo sapiens	0-10
11161606-9	2001	However, acute treatment with salmon calcitonin (1-1000 nM) caused significant potentiation of neuronal death induced by oxygen-glucose deprivation.	oxygen-glucose	121-135	calcitonin related polypeptide alpha	Homo sapiens	37-47
11161606-14	2001	The most interesting, and disturbing, effect is the ability of low concentrations of salmon calcitonin to potentiate oxygen-glucose deprivation-induced cell death.	oxygen-glucose	117-131	calcitonin related polypeptide alpha	Homo sapiens	92-102
11599126-5	2001	Oxygen-glucose deprivation (OGD), cystine-free (inhibition of synthesis of glutathione), cyto-toxic (ethanol, sodium butyrate) treatments resulted in different expression manners between HO-1 and HSP70, which suggested that HO-1 and HSP70 play different protective roles against a variety kind of stressful conditions in glial cells.	oxygen-glucose	0-14	heme oxygenase 1	Rattus norvegicus	187-191
11599126-5	2001	Oxygen-glucose deprivation (OGD), cystine-free (inhibition of synthesis of glutathione), cyto-toxic (ethanol, sodium butyrate) treatments resulted in different expression manners between HO-1 and HSP70, which suggested that HO-1 and HSP70 play different protective roles against a variety kind of stressful conditions in glial cells.	oxygen-glucose	0-14	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	196-201
11599126-5	2001	Oxygen-glucose deprivation (OGD), cystine-free (inhibition of synthesis of glutathione), cyto-toxic (ethanol, sodium butyrate) treatments resulted in different expression manners between HO-1 and HSP70, which suggested that HO-1 and HSP70 play different protective roles against a variety kind of stressful conditions in glial cells.	oxygen-glucose	0-14	heme oxygenase 1	Rattus norvegicus	224-228
11599126-5	2001	Oxygen-glucose deprivation (OGD), cystine-free (inhibition of synthesis of glutathione), cyto-toxic (ethanol, sodium butyrate) treatments resulted in different expression manners between HO-1 and HSP70, which suggested that HO-1 and HSP70 play different protective roles against a variety kind of stressful conditions in glial cells.	oxygen-glucose	0-14	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	233-238
11172929-8	2001	In the in vitro ischemia study, SSAT activity was evaluated in primary cortical neuronal cultures at 6-24 h re-oxygenation intervals following oxygen-glucose deprivation for 1 h, and the results from this group show that the enzyme activity increased by about 62% (P<0.05) at 24 h re-oxygenation.	oxygen-glucose	143-157	spermidine/spermine N1-acetyl transferase 1	Rattus norvegicus	32-36
11720781-7	2001	Specifically, calpain activation, as well as degradation of microtubule-associated protein-2 and postsynaptic density-95, are attenuated 2 h following otherwise lethal NMDA treatment alone or oxygen-glucose deprivation in preconditioned cultures.	oxygen-glucose	192-206	microtubule-associated protein 2	Rattus norvegicus	60-92
11720781-7	2001	Specifically, calpain activation, as well as degradation of microtubule-associated protein-2 and postsynaptic density-95, are attenuated 2 h following otherwise lethal NMDA treatment alone or oxygen-glucose deprivation in preconditioned cultures.	oxygen-glucose	192-206	DLG associated protein 2	Rattus norvegicus	97-120
11720781-8	2001	Formation of microtubule-associated protein-2-labeled dendritic varicosities is also attenuated in preconditioned cultures within 1 h of lethal oxygen-glucose deprivation or NMDA application.	oxygen-glucose	144-158	microtubule-associated protein 2	Rattus norvegicus	13-45
11043535-1	2000	We analysed the influence of oxygen-glucose deprivation (OGD) on the expression of corticotropin releasing factor (CRF) receptors (CRF-R1 and CRF-R2) in fetal hippocampal neurons in vitro.	oxygen-glucose	29-43	corticotropin releasing hormone receptor 1	Homo sapiens	131-137
11043535-1	2000	We analysed the influence of oxygen-glucose deprivation (OGD) on the expression of corticotropin releasing factor (CRF) receptors (CRF-R1 and CRF-R2) in fetal hippocampal neurons in vitro.	oxygen-glucose	29-43	corticotropin releasing hormone receptor 2	Homo sapiens	142-148
10947805-8	2000	Primary neuronal cortical cultures derived from IL-10-/- animals were more susceptible to both excitotoxicity and combined oxygen-glucose deprivation compared with cell cultures from wild-type mice.	oxygen-glucose	123-137	interleukin 10	Mus musculus	48-53
9178862-7	1997	Given the evidence that agonists at this group of mGluR promoted neuronal death in cerebrocortical cultures after oxygen-glucose deprivation or after N-methyl-D-aspartate exposure, our findings suggest that mGluR-mediated excitotoxicity is unlikely associated with mGluR1 but rather with other PLC-coupled mGluR.	oxygen-glucose	114-128	glutamate metabotropic receptor 1	Homo sapiens	265-271
9838190-2	1998	Hypoxia (oxygen-glucose deprivation) elicited a gradual increase in [Ca2+]i in normal Krebs solution.	oxygen-glucose	9-23	carbonic anhydrase 2	Rattus norvegicus	69-72
9754916-2	1998	We have recently demonstrated that inducible NO synthase was expressed within hours after rat forebrain slices were exposed to oxygen-glucose deprivation.	oxygen-glucose	127-141	nitric oxide synthase 2	Rattus norvegicus	35-56
9622236-3	1998	In sharp contrast to controls, in mice lacking the gene for calbindin-D28k, synaptic responses of hippocampal CA1 pyramidal neurons which are normally extremely vulnerable to ischemia, recovered significantly faster and more completely after a transient oxygen-glucose deprivation in vitro, and sustained less cellular damage following a 12 min carotid artery occlusion in vivo.	oxygen-glucose	254-268	calbindin 1	Mus musculus	60-74
9622236-3	1998	In sharp contrast to controls, in mice lacking the gene for calbindin-D28k, synaptic responses of hippocampal CA1 pyramidal neurons which are normally extremely vulnerable to ischemia, recovered significantly faster and more completely after a transient oxygen-glucose deprivation in vitro, and sustained less cellular damage following a 12 min carotid artery occlusion in vivo.	oxygen-glucose	254-268	carbonic anhydrase 1	Mus musculus	110-113
9739997-0	1998	Inhibition of adenosine kinase during oxygen-glucose deprivation in rat cortical neuronal cultures.	oxygen-glucose	38-52	adenosine kinase	Rattus norvegicus	14-30
9310305-2	1997	Hypoxia (oxygen-glucose deprivation) elicited a gradual increase in [Ca2+]i in normal Krebs solution.	oxygen-glucose	9-23	carbonic anhydrase 2	Rattus norvegicus	69-72
9302093-3	1997	Reverse transcription-polymerase chain reaction (RT-PCR) amplification was used to quantify the altered expression of the N-methyl-D-aspartate (NMDA) NR2A, NR2B and NR2C subunits relative to one another in rat hippocampal slices in resistant and vulnerable regions following in vitro oxygen-glucose deprivation.	oxygen-glucose	284-298	glutamate ionotropic receptor NMDA type subunit 2C	Rattus norvegicus	165-169
8714540-0	1996	Mechanism of heat shock protein 72 induction in primary cultured astrocytes after oxygen-glucose deprivation.	oxygen-glucose	82-96	heat shock protein 1A	Mus musculus	13-34
8784134-0	1996	Potentiation of oxygen-glucose deprivation-induced neuronal death after induction of iNOS.	oxygen-glucose	16-30	nitric oxide synthase 2, inducible	Mus musculus	85-89
8784134-8	1996	However, after induction of astrocyte iNOS activity with interferon gamma plus lipopolysaccharide or interleukin-1 beta, oxygen-glucose deprivation-induced neuronal injury was markedly enhanced and nitric oxide synthase inhibitors became protective.	oxygen-glucose	121-135	nitric oxide synthase 2, inducible	Mus musculus	38-42
8784134-8	1996	However, after induction of astrocyte iNOS activity with interferon gamma plus lipopolysaccharide or interleukin-1 beta, oxygen-glucose deprivation-induced neuronal injury was markedly enhanced and nitric oxide synthase inhibitors became protective.	oxygen-glucose	121-135	interleukin 1 beta	Mus musculus	101-119
8730798-0	1996	Over-expression of HSP-70 protects astrocytes from combined oxygen-glucose deprivation.	oxygen-glucose	60-74	heat shock protein family A (Hsp70) member 4	Homo sapiens	19-25
8730798-5	1996	Our data provide direct evidence that selective expression of HSP-70 enhances the survival of astrocytes challenged with heat or oxygen-glucose deprivation.	oxygen-glucose	129-143	heat shock protein family A (Hsp70) member 4	Homo sapiens	62-68
8714540-2	1996	The aim of this study was to compare the mechanism of induction of heat shock protein 72 (HSP72) in primary cultures of murine cortical astrocytes by heat and combined oxygen-glucose deprivation (OGD), a model of in vitro ischemia.	oxygen-glucose	168-182	heat shock protein 1A	Mus musculus	67-88
8714540-2	1996	The aim of this study was to compare the mechanism of induction of heat shock protein 72 (HSP72) in primary cultures of murine cortical astrocytes by heat and combined oxygen-glucose deprivation (OGD), a model of in vitro ischemia.	oxygen-glucose	168-182	heat shock protein 1A	Mus musculus	90-95
32162697-2	2020	Our previous studies have shown that the RIP3/mixed lineage kinase domain-like protein (MLKL)-mediated necroptosis occurs in retinal ganglion cell line 5 (RGC-5) following oxygen-glucose deprivation (OGD).	oxygen-glucose	172-186	mixed lineage kinase domain like pseudokinase	Rattus norvegicus	41-86
7882037-0	1994	Prior mechanical injury inhibits rise in intracellular Ca2+ concentration by oxygen-glucose deprivation in mouse hippocampal slices.	oxygen-glucose	77-91	carbonic anhydrase 2	Mus musculus	55-58
7882037-5	1994	Changes in [Ca2+]i in the slices by oxygen-glucose deprivation were analyzed from fluorescence images, using fura-2.	oxygen-glucose	36-50	carbonic anhydrase 2	Mus musculus	12-15
32162697-2	2020	Our previous studies have shown that the RIP3/mixed lineage kinase domain-like protein (MLKL)-mediated necroptosis occurs in retinal ganglion cell line 5 (RGC-5) following oxygen-glucose deprivation (OGD).	oxygen-glucose	172-186	mixed lineage kinase domain like pseudokinase	Rattus norvegicus	88-92
32219700-14	2020	Inhibition of vesicular BDNF release abolished its protective action targeting inhibition of the oxygen-glucose deprivation (OGD)-induced [Ca2+]i increase in GABAergic and glutamatergic neurons, thus promoting their death.	oxygen-glucose	97-111	brain derived neurotrophic factor	Homo sapiens	24-28
32251645-3	2020	In the present study, we aimed to explore the potential function and molecular mechanism of TRIM16 in regulating oxidative stress in neurons induced by oxygen-glucose deprivation/reoxygenation (OGD/R) in vitro.	oxygen-glucose	152-166	tripartite motif containing 16	Homo sapiens	92-98
31218515-4	2019	The LIF-NSCs reduced caspase 3 activation under conditions of oxygen-glucose deprivation in vitro.	oxygen-glucose	62-76	caspase 3	Rattus norvegicus	21-30
31468997-8	2019	Results: The expression miR-463-3p was robustly increased in the injured tibial nerve in vivo and in tibial nerve cells treated with oxygen-glucose deprivation.	oxygen-glucose	133-147	microRNA 463	Mus musculus	24-31
31415765-11	2019	The oxygen-glucose deprivation in vitro model of stroke further demonstrated that "cold" rat splenocytes protected rat primary neurons by upregulating BDNF and IL-10.	oxygen-glucose	4-18	brain-derived neurotrophic factor	Rattus norvegicus	151-155
31415765-11	2019	The oxygen-glucose deprivation in vitro model of stroke further demonstrated that "cold" rat splenocytes protected rat primary neurons by upregulating BDNF and IL-10.	oxygen-glucose	4-18	interleukin 10	Rattus norvegicus	160-165
32142833-5	2020	Oxygen-glucose deprivation/re-oxygenation (OGD/R) was made in the primitive neuron in vitro, and was respectively treated with autophagy inhibitors 3-MA, LiCl, GSK3beta siRNA, or mTOR inhibitor rapamycin.	oxygen-glucose	0-14	mechanistic target of rapamycin kinase	Rattus norvegicus	179-183
32131693-9	2020	Consistently, lentiviral knockdown of the miR-15a/16-1 cluster in primary mouse or human brain microvascular endothelial cell cultures enhanced in vitro angiogenesis and up-regulated pro-angiogenic proteins expression after oxygen-glucose deprivation (OGD), whereas lentiviral overexpression of the miR-15a/16-1 cluster suppressed in vitro angiogenesis and down-regulated pro-angiogenic proteins expression.	oxygen-glucose	224-238	microRNA 15a	Mus musculus	42-49
30911877-0	2019	Oxygen-Glucose Deprivation/Reoxygenation-Induced Barrier Disruption at the Human Blood-Brain Barrier is Partially Mediated Through the HIF-1 Pathway.	oxygen-glucose	0-14	hypoxia inducible factor 1 subunit alpha	Homo sapiens	135-140
31290452-0	2019	Hyodeoxycholic acid protects the neurovascular unit against oxygen-glucose deprivation and reoxygenation-induced injury in vitro.	oxygen-glucose	60-74	UDP glucuronosyltransferase family 2 member B4	Homo sapiens	0-19
31187440-0	2019	Oxygen-Glucose Deprivation/Reoxygenation Induces Human Brain Microvascular Endothelial Cell Hyperpermeability Via VE-Cadherin Internalization: Roles of RhoA/ROCK2.	oxygen-glucose	0-14	cadherin 5	Homo sapiens	114-125
31509975-4	2019	The effect of oxygen-glucose deprivation (OGD) and reperfusion on the OATP1 expression, uptake, and transport of biphalin was measured in induced pluripotent stem cells differentiated brain microvascular endothelial cells (iPSC-BMECs) in the presence and absence of an OATP1 substrate, estrone-3-sulfate (E3S).	oxygen-glucose	14-28	ornithine aminotransferase pseudogene 1	Homo sapiens	70-75
31200256-3	2019	In this study, we found that miR-874-3p levels significantly decreased in rat I/R brain induced by middle cerebral artery occlusion/reperfusion (MCAO/R) and SH-SY5Y cells following oxygen-glucose deprivation and reperfusion (OGD/R) treatment.	oxygen-glucose	181-195	microRNA 874	Homo sapiens	29-36
31515472-4	2019	Here, we demonstrated an increase of BNIP3 expression in cultured renal proximal tubular epithelial cells following oxygen-glucose deprivation-reperfusion (OGD-R) and in renal tubules after renal ischemia-reperfusion (IR)-induced injury in mice.	oxygen-glucose	116-130	BCL2/adenovirus E1B interacting protein 3	Mus musculus	37-42
31187440-0	2019	Oxygen-Glucose Deprivation/Reoxygenation Induces Human Brain Microvascular Endothelial Cell Hyperpermeability Via VE-Cadherin Internalization: Roles of RhoA/ROCK2.	oxygen-glucose	0-14	ras homolog family member A	Homo sapiens	152-156
31187440-0	2019	Oxygen-Glucose Deprivation/Reoxygenation Induces Human Brain Microvascular Endothelial Cell Hyperpermeability Via VE-Cadherin Internalization: Roles of RhoA/ROCK2.	oxygen-glucose	0-14	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	157-162
31426811-7	2019	RESULTS: After oxygen-glucose deprivation (OGD), iNOS mRNA expression increased to the peak at 6 h in primary astrocytes, but keep baseline expression in LCN2-knockout astrocytes.	oxygen-glucose	15-29	nitric oxide synthase 2, inducible	Mus musculus	49-53
31410708-3	2019	In the present study, we evaluated the expression level of TRIM32 in hippocampal neurons following oxygen-glucose deprivation/reperfusion (OGD/R).	oxygen-glucose	99-113	tripartite motif containing 32	Homo sapiens	59-65
31485266-5	2019	The expression of miR-138-5p and LCN2 was altered in the oxygen-glucose deprivation (OGD)-induced astrocytes.	oxygen-glucose	57-71	lipocalin 2	Mus musculus	33-37
31199929-0	2019	Downregulation of microRNA-302b-3p relieves oxygen-glucose deprivation/re-oxygenation induced injury in murine hippocampal neurons through up-regulating Nrf2 signaling by targeting fibroblast growth factor 15/19.	oxygen-glucose	44-58	nuclear factor, erythroid derived 2, like 2	Mus musculus	153-157
31199929-0	2019	Downregulation of microRNA-302b-3p relieves oxygen-glucose deprivation/re-oxygenation induced injury in murine hippocampal neurons through up-regulating Nrf2 signaling by targeting fibroblast growth factor 15/19.	oxygen-glucose	44-58	fibroblast growth factor 15	Mus musculus	181-208
31199929-4	2019	In the present study, we explored the potential function and molecular mechanism of miR-302b-3p in oxygen-glucose deprivation/re-oxygenation (OGD/R)-induced neuronal injury, using an in vitro model of cerebral ischaemia/reperfusion injury.	oxygen-glucose	99-113	microRNA 302b	Mus musculus	84-92
31447648-9	2019	In addition, TMEM16A silencing rescued oxygen-glucose deprivation/reoxygenation (OGD/R)-induced transendothelial permeability in vitro accompanied by decreased ICAM-1 expression and leukocyte adhesion.	oxygen-glucose	39-53	anoctamin 1, calcium activated chloride channel	Mus musculus	13-20
31150684-0	2019	MiR-145 protected the cell viability of human cerebral cortical neurons after oxygen-glucose deprivation by downregulating EPHA4.	oxygen-glucose	78-92	microRNA 145	Homo sapiens	0-7
31406177-5	2019	Here, we show that selective inhibition of PFKFB3 activity by the small molecule AZ67 prevents the NADPH oxidation, redox stress and apoptotic cell death caused by the activation of glycolysis triggered upon excitotoxic and oxygen-glucose deprivation/reoxygenation models in mouse primary neurons.	oxygen-glucose	224-238	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Mus musculus	43-49
31447648-9	2019	In addition, TMEM16A silencing rescued oxygen-glucose deprivation/reoxygenation (OGD/R)-induced transendothelial permeability in vitro accompanied by decreased ICAM-1 expression and leukocyte adhesion.	oxygen-glucose	39-53	intercellular adhesion molecule 1	Mus musculus	160-166
30945345-0	2019	Platycodin D protects cortical neurons against oxygen-glucose deprivation/reperfusion in neonatal hypoxic-ischemic encephalopathy.	oxygen-glucose	47-61	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-12
30945345-5	2019	We found that oxygen-glucose deprivation/reperfusion (OGD/R) induced inhibition of cell viability and cytotoxicity, which were attenuated by PLD treatment.	oxygen-glucose	14-28	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	141-144
30666890-0	2019	Delta Opioid Peptide [d-Ala2, d-Leu5] Enkephalin (DADLE) Exerts a Cytoprotective Effect in Astrocytes Exposed to Oxygen-Glucose Deprivation by Inducing Autophagy.	oxygen-glucose	113-127	proenkephalin	Rattus norvegicus	38-48
31152933-0	2019	Oxygen-Glucose Deprivation Differentially Affects Neocortical Pyramidal Neurons and Parvalbumin-Positive Interneurons.	oxygen-glucose	0-14	parvalbumin	Mus musculus	84-95
31167620-6	2019	Results- We found expression of Nespas was significantly increased in ischemic cerebral tissues and oxygen-glucose deprivation-treated BV2 cells in a time-dependent manner.	oxygen-glucose	100-114	GNAS antisense RNA 1	Mus musculus	32-38
31167620-11	2019	Conclusions- We showed that Nespas played anti-inflammatory and antiapoptotic roles in cultured microglial cells after oxygen-glucose deprivation stimulation and in mice after ischemic stroke by inhibiting TRIM8-related K63-linked polyubiquitination of TAK1.	oxygen-glucose	119-133	GNAS antisense RNA 1	Mus musculus	28-34
31167620-11	2019	Conclusions- We showed that Nespas played anti-inflammatory and antiapoptotic roles in cultured microglial cells after oxygen-glucose deprivation stimulation and in mice after ischemic stroke by inhibiting TRIM8-related K63-linked polyubiquitination of TAK1.	oxygen-glucose	119-133	tripartite motif-containing 8	Mus musculus	206-211
30926681-0	2019	Suppression of lncRNA RMRP ameliorates oxygen-glucose deprivation/re-oxygenation-induced neural cells injury by inhibiting autophagy and PI3K/Akt/mTOR-mediated apoptosis.	oxygen-glucose	39-53	RNA component of mitochondrial RNA processing endoribonuclease	Homo sapiens	22-26
30926681-0	2019	Suppression of lncRNA RMRP ameliorates oxygen-glucose deprivation/re-oxygenation-induced neural cells injury by inhibiting autophagy and PI3K/Akt/mTOR-mediated apoptosis.	oxygen-glucose	39-53	AKT serine/threonine kinase 1	Homo sapiens	142-145
30926681-0	2019	Suppression of lncRNA RMRP ameliorates oxygen-glucose deprivation/re-oxygenation-induced neural cells injury by inhibiting autophagy and PI3K/Akt/mTOR-mediated apoptosis.	oxygen-glucose	39-53	mechanistic target of rapamycin kinase	Homo sapiens	146-150
30926681-3	2019	In order to determine the role of RMRP in I/R injury, the effects of RMRP knockdown on oxygen-glucose deprivation/re-oxygenation (OGD/R)-induced injury in SH-SY5Y cells were evaluated.	oxygen-glucose	87-101	RNA component of mitochondrial RNA processing endoribonuclease	Homo sapiens	69-73
30317635-0	2019	X-box binding protein l splicing attenuates brain microvascular endothelial cell damage induced by oxygen-glucose deprivation through the activation of phosphoinositide 3-kinase/protein kinase B, extracellular signal-regulated kinases, and hypoxia-inducible factor-1alpha/vascular endothelial growth factor signaling pathways.	oxygen-glucose	99-113	hypoxia inducible factor 1 subunit alpha	Homo sapiens	196-271
30317635-0	2019	X-box binding protein l splicing attenuates brain microvascular endothelial cell damage induced by oxygen-glucose deprivation through the activation of phosphoinositide 3-kinase/protein kinase B, extracellular signal-regulated kinases, and hypoxia-inducible factor-1alpha/vascular endothelial growth factor signaling pathways.	oxygen-glucose	99-113	vascular endothelial growth factor A	Homo sapiens	272-306
30317635-6	2019	In this study, the roles of XBP1s on cell survival, apoptosis, cycle migration, and angiogenesis were determined in oxygen-glucose deprivation (OGD) treated BMECs.	oxygen-glucose	116-130	X-box binding protein 1	Homo sapiens	28-32
31164807-3	2019	This study aimed to explore the effect of microRNA-210 (miR-210) on EPCs under oxygen-glucose deprivation (OGD) conditions.	oxygen-glucose	79-93	microRNA 210	Homo sapiens	42-54
30949956-0	2019	The Neuroprotective Effect of miR-181a After Oxygen-Glucose Deprivation/Reperfusion and the Associated Mechanism.	oxygen-glucose	45-59	microRNA 181a-2	Mus musculus	30-38
30949956-1	2019	The level of miR-181a decreases rapidly in N2a cells following oxygen-glucose deprivation/reperfusion, but its role in this process is unclear.	oxygen-glucose	63-77	microRNA 181a-2	Mus musculus	13-21
30949956-6	2019	We also evaluated the effect of miR-181a on the Smac/IAP signaling pathway after oxygen-glucose deprivation and reperfusion in N2a cells.	oxygen-glucose	81-95	diablo, IAP-binding mitochondrial protein	Mus musculus	48-52
30949956-9	2019	Pre-treatment with miR-181a mimicked the increase in the miR-181a level in N2a cells after oxygen-glucose deprivation/reperfusion, resulting in a significant decrease in the apoptosis rate.	oxygen-glucose	91-105	microRNA 181a-2	Mus musculus	19-27
30949956-9	2019	Pre-treatment with miR-181a mimicked the increase in the miR-181a level in N2a cells after oxygen-glucose deprivation/reperfusion, resulting in a significant decrease in the apoptosis rate.	oxygen-glucose	91-105	microRNA 181a-2	Mus musculus	57-65
31059068-7	2019	Reoxygenation following oxygen-glucose deprivation (OGD) decreased cell viability and the expression levels of COX6B1 in a time-dependent manner, and 60 min of reoxygenation was identified as the optimal time period for establishing an ischemia/reperfusion (I/R) model.	oxygen-glucose	24-38	cytochrome c oxidase subunit VIb polypeptide 1, pseudogene 1	Rattus norvegicus	111-117
31164807-3	2019	This study aimed to explore the effect of microRNA-210 (miR-210) on EPCs under oxygen-glucose deprivation (OGD) conditions.	oxygen-glucose	79-93	microRNA 210	Homo sapiens	56-63
30785093-6	2019	We found that the expression of CKLF1 was increased in BV2 microglia with oxygen-glucose deprivation/reperfusion, and IMM-H004 decreased this specially increased expression.	oxygen-glucose	74-88	chemokine like factor	Homo sapiens	32-37
30742923-0	2019	Circular RNA circPTK2 regulates oxygen-glucose deprivation-activated microglia-induced hippocampal neuronal apoptosis via miR-29b-SOCS-1-JAK2/STAT3-IL-1beta signaling.	oxygen-glucose	32-46	microRNA 29b-1	Homo sapiens	122-129
30742923-0	2019	Circular RNA circPTK2 regulates oxygen-glucose deprivation-activated microglia-induced hippocampal neuronal apoptosis via miR-29b-SOCS-1-JAK2/STAT3-IL-1beta signaling.	oxygen-glucose	32-46	suppressor of cytokine signaling 1	Homo sapiens	130-136
30742923-0	2019	Circular RNA circPTK2 regulates oxygen-glucose deprivation-activated microglia-induced hippocampal neuronal apoptosis via miR-29b-SOCS-1-JAK2/STAT3-IL-1beta signaling.	oxygen-glucose	32-46	Janus kinase 2	Homo sapiens	137-141
30742923-0	2019	Circular RNA circPTK2 regulates oxygen-glucose deprivation-activated microglia-induced hippocampal neuronal apoptosis via miR-29b-SOCS-1-JAK2/STAT3-IL-1beta signaling.	oxygen-glucose	32-46	signal transducer and activator of transcription 3	Homo sapiens	142-147
30742923-0	2019	Circular RNA circPTK2 regulates oxygen-glucose deprivation-activated microglia-induced hippocampal neuronal apoptosis via miR-29b-SOCS-1-JAK2/STAT3-IL-1beta signaling.	oxygen-glucose	32-46	interleukin 1 beta	Homo sapiens	148-156
30988756-3	2019	The aim of the current study was to investigate the impact of miR-21 and its target gene, programmed cell death protein 4 (PDCD4), on the protective effect of GS-Rb1 in cardiomyocytes injured by oxygen-glucose deprivation (OGD).	oxygen-glucose	195-209	microRNA 21	Rattus norvegicus	62-68
30988756-3	2019	The aim of the current study was to investigate the impact of miR-21 and its target gene, programmed cell death protein 4 (PDCD4), on the protective effect of GS-Rb1 in cardiomyocytes injured by oxygen-glucose deprivation (OGD).	oxygen-glucose	195-209	programmed cell death 4	Rattus norvegicus	90-121
30988756-3	2019	The aim of the current study was to investigate the impact of miR-21 and its target gene, programmed cell death protein 4 (PDCD4), on the protective effect of GS-Rb1 in cardiomyocytes injured by oxygen-glucose deprivation (OGD).	oxygen-glucose	195-209	programmed cell death 4	Rattus norvegicus	123-128
31137455-2	2019	Thrombin preconditioning significantly enhances the neuroprotective anti-oxidative, anti-apoptotic, and anti-cytotoxic effects of naive MSCs against oxygen-glucose deprivation (OGD) of cortical neurons in vitro.	oxygen-glucose	149-163	coagulation factor II, thrombin	Homo sapiens	0-8
30785093-10	2019	Furthermore, the Co-IP assay showed that IMM-H004 decreased the amount of CKLF1 binding to CC chemokine receptor 4 in the BV2 microglia oxygen-glucose deprivation/reperfusion model.	oxygen-glucose	136-150	chemokine like factor	Homo sapiens	74-79
30923227-10	2019	Knocking out CB2R decreased the level of autophagy in heart issues from MI mice as well as cardiomyocytes under oxygen-glucose deprivation (OGD).	oxygen-glucose	112-126	cannabinoid receptor 2 (macrophage)	Mus musculus	13-17
31073355-4	2019	In this study, we found that BRCA1 was upregulated by oxygen-glucose deprivation/reoxygenation (OGD/R).	oxygen-glucose	54-68	breast cancer 1, early onset	Mus musculus	29-34
30961627-9	2019	RESULTS: In this study, we showed that LncRNA-1810034E14Rik was significantly decreased in LPS-treated or oxygen-glucose deprivation-induced microglial cells.	oxygen-glucose	106-120	RIKEN cDNA 1810034E14 gene	Mus musculus	46-59
30961627-11	2019	1810034E14Rik overexpression reduced the expression of inflammatory cytokines not only in ischemic stroke mice but also in oxygen-glucose deprivation-induced microglial cells.	oxygen-glucose	123-137	RIKEN cDNA 1810034E14 gene	Mus musculus	0-13
30784209-0	2019	Long non-coding RNA MALAT1 regulates angiogenesis following oxygen-glucose deprivation/reoxygenation.	oxygen-glucose	60-74	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	20-26
30658115-0	2019	CKIP-1 alleviates oxygen-glucose deprivation/reoxygenation-induced apoptosis and oxidative stress in cultured hippocampal neurons by downregulating Keap1 and activating Nrf2/ARE signaling.	oxygen-glucose	18-32	pleckstrin homology domain containing O1	Homo sapiens	0-6
30658115-0	2019	CKIP-1 alleviates oxygen-glucose deprivation/reoxygenation-induced apoptosis and oxidative stress in cultured hippocampal neurons by downregulating Keap1 and activating Nrf2/ARE signaling.	oxygen-glucose	18-32	kelch like ECH associated protein 1	Homo sapiens	148-153
30658115-0	2019	CKIP-1 alleviates oxygen-glucose deprivation/reoxygenation-induced apoptosis and oxidative stress in cultured hippocampal neurons by downregulating Keap1 and activating Nrf2/ARE signaling.	oxygen-glucose	18-32	NFE2 like bZIP transcription factor 2	Homo sapiens	169-173
31138990-0	2019	C3a Receptor Inhibition Protects Brain Endothelial Cells Against Oxygen-glucose Deprivation/Reperfusion.	oxygen-glucose	65-79	complement C3	Homo sapiens	0-3
30784209-3	2019	Our studies focused on deciphering the functional roles and the underlying mechanisms of the lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in the process of angiogenesis following oxygen-glucose deprivation/reoxygenation (OGD/R).	oxygen-glucose	205-219	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	156-162
30783424-3	2019	In the present study, miR-196a expression was significantly increased in rat brains and neurons following transient middle cerebral artery occlusion (MCAO) or oxygen-glucose deprivation, respectively.	oxygen-glucose	159-173	microRNA 196a	Rattus norvegicus	22-30
30632499-8	2019	Primary rat neurons and astrocytes were protected from oxygen-glucose deprivation by hMSCs, which was antagonized by the Bcl-2 antibody.	oxygen-glucose	55-69	BCL2, apoptosis regulator	Rattus norvegicus	121-126
30576531-2	2019	In this study, we found that Smox expression was increased in a rat middle cerebral artery occlusion (MCAO) model and in cultured primary neurons after oxygen-glucose deprivation and reoxygenation (OGD/R).	oxygen-glucose	152-166	spermine oxidase	Rattus norvegicus	29-33
30746745-3	2019	In this study, we found that recombinant mouse (rm) IL-17A could significantly (P < 0.05 or <0.001) alleviate 1-hour oxygen-glucose deprivation (OGD)/reoxygenation (R) 24-hour-induced ischemic injuries in cortical astrocytes with a dose-dependent manner (n = 6 per group).	oxygen-glucose	123-137	interleukin 17A	Mus musculus	52-58
30867725-3	2019	In the current study, protective effects of the epidermal growth factor (EGF) on ischemia-induced disruption of BBB integrity were examined using an oxygen-glucose deprivation (OGD) model in bEnd3 cells.	oxygen-glucose	149-163	epidermal growth factor	Mus musculus	73-76
30937308-0	2019	Leukemia Inhibitory Factor Receptor Is Involved in Apoptosis in Rat Astrocytes Exposed to Oxygen-Glucose Deprivation.	oxygen-glucose	90-104	LIF receptor subunit alpha	Rattus norvegicus	0-35
30937308-1	2019	Leukemia inhibitory factor (LIF) and leukemia inhibitory factor receptor (Lifr) protect CNS cells, specifically neurons and myelin-sheath oligodendrocytes, in conditions of oxygen-glucose deprivation (OGD).	oxygen-glucose	173-187	LIF, interleukin 6 family cytokine	Rattus norvegicus	0-32
30937308-1	2019	Leukemia inhibitory factor (LIF) and leukemia inhibitory factor receptor (Lifr) protect CNS cells, specifically neurons and myelin-sheath oligodendrocytes, in conditions of oxygen-glucose deprivation (OGD).	oxygen-glucose	173-187	LIF receptor subunit alpha	Rattus norvegicus	37-72
30937308-1	2019	Leukemia inhibitory factor (LIF) and leukemia inhibitory factor receptor (Lifr) protect CNS cells, specifically neurons and myelin-sheath oligodendrocytes, in conditions of oxygen-glucose deprivation (OGD).	oxygen-glucose	173-187	LIF receptor subunit alpha	Rattus norvegicus	74-78
30705770-5	2019	The aim of this study was to determine whether DRAM is involved in oxygen-glucose deprivation (OGD)-induced hepatocyte autophagic apoptosis.	oxygen-glucose	67-81	DNA-damage regulated autophagy modulator 1	Mus musculus	47-51
30804781-6	2019	Furthermore, the presumed mechanism was confirmed through biological analysis by determining the effects of CEE on the identified signaling pathways in PC12 cells model-induced by oxygen-glucose deprivation/reperfusion (OGD/R).	oxygen-glucose	180-194	guided entry of tail-anchored proteins factor 4	Rattus norvegicus	108-111
30513376-0	2019	Oxygen-Glucose Deprivation in Mouse Astrocytes is Associated with Ultrastructural Changes in Connexin 43 Gap Junctions.	oxygen-glucose	0-14	gap junction protein, alpha 1	Mus musculus	93-104
31250610-1	2019	OBJECTIVE: To investigate the effects of Notch signal on hypoxic induction factor (HIF-1alpha) and autophagy-associated genes Beclin1, LC3I, LC3II in oxygen-glucose deprivation (OGD) induced myocardial cell injury.	oxygen-glucose	150-164	notch receptor 1	Homo sapiens	41-46
31250610-1	2019	OBJECTIVE: To investigate the effects of Notch signal on hypoxic induction factor (HIF-1alpha) and autophagy-associated genes Beclin1, LC3I, LC3II in oxygen-glucose deprivation (OGD) induced myocardial cell injury.	oxygen-glucose	150-164	hypoxia inducible factor 1 subunit alpha	Homo sapiens	83-93
31250610-1	2019	OBJECTIVE: To investigate the effects of Notch signal on hypoxic induction factor (HIF-1alpha) and autophagy-associated genes Beclin1, LC3I, LC3II in oxygen-glucose deprivation (OGD) induced myocardial cell injury.	oxygen-glucose	150-164	beclin 1	Homo sapiens	126-133
30496821-0	2019	MALAT1 lncRNA Induces Autophagy and Protects Brain Microvascular Endothelial Cells Against Oxygen-Glucose Deprivation by Binding to miR-200c-3p and Upregulating SIRT1 Expression.	oxygen-glucose	91-105	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	0-6
30309728-0	2019	MMP-9 Upregulation is Attenuated by the Monoclonal TLR2 Antagonist T2.5 After Oxygen-Glucose Deprivation and Reoxygenation in Rat Brain Microvascular Endothelial Cells.	oxygen-glucose	78-92	matrix metallopeptidase 9	Rattus norvegicus	0-5
30747083-2	2019	We studied the neuroprotective effects of GSP against oxygen-glucose deprivation/reoxygenation (OGD/R) injury and the potential mechanisms in mouse neuroblastoma N2a cells.	oxygen-glucose	54-68	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	Mus musculus	42-45
30460429-0	2019	APC-Cdh1 Regulates Neuronal Apoptosis Through Modulating Glycolysis and Pentose-Phosphate Pathway After Oxygen-Glucose Deprivation and Reperfusion.	oxygen-glucose	104-118	cadherin 1	Homo sapiens	4-8
30309728-0	2019	MMP-9 Upregulation is Attenuated by the Monoclonal TLR2 Antagonist T2.5 After Oxygen-Glucose Deprivation and Reoxygenation in Rat Brain Microvascular Endothelial Cells.	oxygen-glucose	78-92	toll-like receptor 2	Rattus norvegicus	51-55
30309728-5	2019	The aim of the study was to evaluate the impact of TLR2 and MMP-2/9 on tight junction proteins (TJs) after oxygen-glucose deprivation and reoxygenation (OGDR).	oxygen-glucose	107-121	toll-like receptor 2	Rattus norvegicus	51-55
30618618-7	2018	Moreover, our results also suggested that up-regulated miR-132 suppressed SOX2 in primary neurons after oxygen-glucose deprivation (OGD), which promoted neurite outgrowth.	oxygen-glucose	104-118	microRNA 132	Homo sapiens	55-62
30618618-7	2018	Moreover, our results also suggested that up-regulated miR-132 suppressed SOX2 in primary neurons after oxygen-glucose deprivation (OGD), which promoted neurite outgrowth.	oxygen-glucose	104-118	SRY-box transcription factor 2	Homo sapiens	74-78
30613272-11	2018	Furthermore, genome-wide RNA sequencing (RNA-seq) analysis revealed that peroxiredoxin4 (PRDX4) was highly expressed in MSCs, which mainly contributed to their antioxidant impacts on MCAO rats and oxygen-glucose deprivation (OGD)-treated endothelium.	oxygen-glucose	197-211	peroxiredoxin 4	Rattus norvegicus	73-87
30449595-0	2018	MicroRNA-98-5p ameliorates oxygen-glucose deprivation/reoxygenation (OGD/R)-induced neuronal injury by inhibiting Bach1 and promoting Nrf2/ARE signaling.	oxygen-glucose	27-41	BTB domain and CNC homolog 1	Homo sapiens	114-119
30449595-0	2018	MicroRNA-98-5p ameliorates oxygen-glucose deprivation/reoxygenation (OGD/R)-induced neuronal injury by inhibiting Bach1 and promoting Nrf2/ARE signaling.	oxygen-glucose	27-41	NFE2 like bZIP transcription factor 2	Homo sapiens	134-138
30449595-3	2018	In this study, we investigated the role and mechanism of miR-98-5p in regulating neuronal injury induced by oxygen-glucose deprivation/reoxygenation (OGD/R), an in vitro model of cerebral ischemia/reperfusion injury.	oxygen-glucose	108-122	microRNA 98	Homo sapiens	57-63
30372823-0	2018	Brahma-related gene 1 ameliorates the neuronal apoptosis and oxidative stress induced by oxygen-glucose deprivation/reoxygenation through activation of Nrf2/HO-1 signaling.	oxygen-glucose	89-103	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	0-21
30372823-0	2018	Brahma-related gene 1 ameliorates the neuronal apoptosis and oxidative stress induced by oxygen-glucose deprivation/reoxygenation through activation of Nrf2/HO-1 signaling.	oxygen-glucose	89-103	NFE2 like bZIP transcription factor 2	Homo sapiens	152-156
30372823-0	2018	Brahma-related gene 1 ameliorates the neuronal apoptosis and oxidative stress induced by oxygen-glucose deprivation/reoxygenation through activation of Nrf2/HO-1 signaling.	oxygen-glucose	89-103	heme oxygenase 1	Homo sapiens	157-161
30372823-2	2018	This study aimed to investigate the expression, biological function, and regulatory mechanism of Brg1 in regulating neuronal apoptosis and oxidative stress induced by oxygen-glucose deprivation/reoxygenation (OGD/R), an in vitro cellular model of cerebral ischemia and reperfusion injury.	oxygen-glucose	167-181	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	97-101
29947255-0	2018	Adiponectin Attenuates Oxygen-Glucose Deprivation-Induced Mitochondrial Oxidative Injury and Apoptosis in Hippocampal HT22 Cells via the JAK2/STAT3 Pathway.	oxygen-glucose	23-37	adiponectin, C1Q and collagen domain containing	Mus musculus	0-11
29947255-0	2018	Adiponectin Attenuates Oxygen-Glucose Deprivation-Induced Mitochondrial Oxidative Injury and Apoptosis in Hippocampal HT22 Cells via the JAK2/STAT3 Pathway.	oxygen-glucose	23-37	Janus kinase 2	Mus musculus	137-141
29947255-0	2018	Adiponectin Attenuates Oxygen-Glucose Deprivation-Induced Mitochondrial Oxidative Injury and Apoptosis in Hippocampal HT22 Cells via the JAK2/STAT3 Pathway.	oxygen-glucose	23-37	signal transducer and activator of transcription 3	Mus musculus	142-147
30191459-5	2018	We cultured rat primary astrocytes and confirmed that GMFB was also up-regulated in primary astrocytes after oxygen-glucose deprivation (OGD).	oxygen-glucose	109-123	glia maturation factor, beta	Rattus norvegicus	54-58
30613272-11	2018	Furthermore, genome-wide RNA sequencing (RNA-seq) analysis revealed that peroxiredoxin4 (PRDX4) was highly expressed in MSCs, which mainly contributed to their antioxidant impacts on MCAO rats and oxygen-glucose deprivation (OGD)-treated endothelium.	oxygen-glucose	197-211	peroxiredoxin 4	Rattus norvegicus	89-94
29908183-3	2018	The present study was designed to evaluate the effect of MIF on oxygen-glucose deprivation (OGD)-induced ototoxicity and to elucidate its molecular mechanism.	oxygen-glucose	64-78	macrophage migration inhibitory factor	Homo sapiens	57-60
30053446-2	2018	In this study, we aimed to investigate the role of Elk1 in cortical neurons under oxygen-glucose deprivation (OGD) conditions.	oxygen-glucose	82-96	ETS transcription factor ELK1	Homo sapiens	51-55
30355116-8	2018	In cultured neurons, the Sema3A inhibitor decreased Rho family GTPase 1, increased R-Ras, which phosphorylates Akt and glycogen synthase kinase 3beta (GSK-3beta), selectively increased phosphorylated GSK-3beta in axons, and thereby enhanced phosphorylated high-molecular weight neurofilament-immunoreactive axons after oxygen-glucose deprivation.	oxygen-glucose	319-333	glycogen synthase kinase 3 beta	Rattus norvegicus	151-160
30355116-9	2018	In cultured astrocytes, the Sema3A inhibitor suppressed activation of astrocytes induced by oxygen-glucose deprivation.	oxygen-glucose	92-106	semaphorin 3A	Rattus norvegicus	28-34
30193860-3	2018	LncRNA small nucleolar RNA host gene 12 (SNHG12) was upregulated in oxygen-glucose deprivation (OGD)-exposed primary brain microvascular endothelial cells and in microvessel from middle cerebral artery occlusion (MCAO) animal brains.	oxygen-glucose	68-82	small nucleolar RNA host gene 12	Mus musculus	7-39
30193860-3	2018	LncRNA small nucleolar RNA host gene 12 (SNHG12) was upregulated in oxygen-glucose deprivation (OGD)-exposed primary brain microvascular endothelial cells and in microvessel from middle cerebral artery occlusion (MCAO) animal brains.	oxygen-glucose	68-82	small nucleolar RNA host gene 12	Mus musculus	41-47
30338821-0	2018	Dexmedetomidine protects liver cell line L-02 from oxygen-glucose deprivation-induced injury by down-regulation of microRNA-711.	oxygen-glucose	51-65	microRNA 711	Homo sapiens	115-127
30524671-0	2018	Kalirin-7 plays a neuroprotective role in Neuro-2A cells injured by oxygen-glucose deprivation and reperfusion through Rac1 activation.	oxygen-glucose	68-82	Rac family small GTPase 1	Mus musculus	119-123
30355116-8	2018	In cultured neurons, the Sema3A inhibitor decreased Rho family GTPase 1, increased R-Ras, which phosphorylates Akt and glycogen synthase kinase 3beta (GSK-3beta), selectively increased phosphorylated GSK-3beta in axons, and thereby enhanced phosphorylated high-molecular weight neurofilament-immunoreactive axons after oxygen-glucose deprivation.	oxygen-glucose	319-333	semaphorin 3A	Rattus norvegicus	25-31
29476448-7	2018	Inhibition of Rac1 reduced axonal length and number in cultured primary mouse cortical neurons using microfluidic chambers after oxygen-glucose deprivation (OGD) without affecting cell viability.	oxygen-glucose	129-143	Rac family small GTPase 1	Mus musculus	14-18
30191592-5	2018	The results demonstrated that levels of miR-134 in BMSCs-exosome decreased but increased incaspase-8 after oxygen-glucose deprivation (OGD) treatment.	oxygen-glucose	107-121	microRNA 134	Rattus norvegicus	40-47
30185785-5	2018	The in vitro study showed that oxygen-glucose deprivation/restoration (OGD/R) induced the expression of the Ang1 receptor Tie2 on BECs in a manner similar to that for integrin alpha5 and Ang1 in response to OGD/R, accompanied by increased activation of Tie2 and its downstream effectors focal adhesion kinase (FAK) and Akt.	oxygen-glucose	31-45	TEK receptor tyrosine kinase	Homo sapiens	253-257
30185785-5	2018	The in vitro study showed that oxygen-glucose deprivation/restoration (OGD/R) induced the expression of the Ang1 receptor Tie2 on BECs in a manner similar to that for integrin alpha5 and Ang1 in response to OGD/R, accompanied by increased activation of Tie2 and its downstream effectors focal adhesion kinase (FAK) and Akt.	oxygen-glucose	31-45	protein tyrosine kinase 2	Homo sapiens	287-308
30185785-5	2018	The in vitro study showed that oxygen-glucose deprivation/restoration (OGD/R) induced the expression of the Ang1 receptor Tie2 on BECs in a manner similar to that for integrin alpha5 and Ang1 in response to OGD/R, accompanied by increased activation of Tie2 and its downstream effectors focal adhesion kinase (FAK) and Akt.	oxygen-glucose	31-45	angiopoietin 1	Homo sapiens	108-112
30185785-5	2018	The in vitro study showed that oxygen-glucose deprivation/restoration (OGD/R) induced the expression of the Ang1 receptor Tie2 on BECs in a manner similar to that for integrin alpha5 and Ang1 in response to OGD/R, accompanied by increased activation of Tie2 and its downstream effectors focal adhesion kinase (FAK) and Akt.	oxygen-glucose	31-45	TEK receptor tyrosine kinase	Homo sapiens	122-126
30185785-5	2018	The in vitro study showed that oxygen-glucose deprivation/restoration (OGD/R) induced the expression of the Ang1 receptor Tie2 on BECs in a manner similar to that for integrin alpha5 and Ang1 in response to OGD/R, accompanied by increased activation of Tie2 and its downstream effectors focal adhesion kinase (FAK) and Akt.	oxygen-glucose	31-45	protein tyrosine kinase 2	Homo sapiens	310-313
30185785-5	2018	The in vitro study showed that oxygen-glucose deprivation/restoration (OGD/R) induced the expression of the Ang1 receptor Tie2 on BECs in a manner similar to that for integrin alpha5 and Ang1 in response to OGD/R, accompanied by increased activation of Tie2 and its downstream effectors focal adhesion kinase (FAK) and Akt.	oxygen-glucose	31-45	AKT serine/threonine kinase 1	Homo sapiens	319-322
29851220-0	2018	Dexmedetomidine protects hepatic cells against oxygen-glucose deprivation/reperfusion injury via lncRNA CCAT1.	oxygen-glucose	47-61	colon cancer associated transcript 1	Homo sapiens	104-109
29883549-0	2018	Upregulated long noncoding RNA Snhg1 promotes the angiogenesis of brain microvascular endothelial cells after oxygen-glucose deprivation treatment by targeting miR-199a.	oxygen-glucose	110-124	small nucleolar RNA host gene 1	Homo sapiens	31-36
29704604-1	2018	We investigated the transforming growth factor-b1 (TGF-beta1)/Smad3 signaling pathway in rats with cerebral ischemia and oxygen-glucose-deprived (OGD) microglia.	oxygen-glucose	121-135	SMAD family member 3	Rattus norvegicus	62-67
30066915-0	2018	Ginkgolide K protects SH-SY5Y cells against oxygen-glucose deprivation-induced injury by inhibiting the p38 and JNK signaling pathways.	oxygen-glucose	44-58	mitogen-activated protein kinase 8	Homo sapiens	112-115
29704604-0	2018	Functional importance of the TGF-beta1/Smad3 signaling pathway in oxygen-glucose-deprived (OGD) microglia and rats with cerebral ischemia.	oxygen-glucose	66-80	transforming growth factor, beta 1	Rattus norvegicus	29-38
29704604-0	2018	Functional importance of the TGF-beta1/Smad3 signaling pathway in oxygen-glucose-deprived (OGD) microglia and rats with cerebral ischemia.	oxygen-glucose	66-80	SMAD family member 3	Rattus norvegicus	39-44
29704604-1	2018	We investigated the transforming growth factor-b1 (TGF-beta1)/Smad3 signaling pathway in rats with cerebral ischemia and oxygen-glucose-deprived (OGD) microglia.	oxygen-glucose	121-135	transforming growth factor, beta 1	Rattus norvegicus	51-60
30066844-8	2018	Treatment with exogenous CART promoted the survival of ex vivo neurons following oxygen-glucose deprivation (OGD), while exogenous DA induced CART mRNA expression in a dose-dependent manner, which suggested an association between CART and DA.	oxygen-glucose	81-95	CART prepropeptide	Mus musculus	25-29
29951932-0	2018	Minocycline Promotes BDNF Expression of N2a Cells via Inhibition of miR-155-Mediated Repression After Oxygen-Glucose Deprivation and Reoxygenation.	oxygen-glucose	102-116	microRNA 155	Mus musculus	68-75
29028769-7	2018	Oxygen-glucose deprivation/reperfusion (OGD/R) was used to make injury in cultured Caco-2 cells pretreated with FXR agonist (INT-747) or DL-propargylglycine (PAG) for 24 h. Cell viability and the expressions of NF-kappaB, TNF-alpha, and IL-6 were assessed.	oxygen-glucose	0-14	nuclear receptor subfamily 1 group H member 4	Homo sapiens	112-115
29028769-7	2018	Oxygen-glucose deprivation/reperfusion (OGD/R) was used to make injury in cultured Caco-2 cells pretreated with FXR agonist (INT-747) or DL-propargylglycine (PAG) for 24 h. Cell viability and the expressions of NF-kappaB, TNF-alpha, and IL-6 were assessed.	oxygen-glucose	0-14	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	211-220
29028769-7	2018	Oxygen-glucose deprivation/reperfusion (OGD/R) was used to make injury in cultured Caco-2 cells pretreated with FXR agonist (INT-747) or DL-propargylglycine (PAG) for 24 h. Cell viability and the expressions of NF-kappaB, TNF-alpha, and IL-6 were assessed.	oxygen-glucose	0-14	tumor necrosis factor	Mus musculus	222-231
29028769-7	2018	Oxygen-glucose deprivation/reperfusion (OGD/R) was used to make injury in cultured Caco-2 cells pretreated with FXR agonist (INT-747) or DL-propargylglycine (PAG) for 24 h. Cell viability and the expressions of NF-kappaB, TNF-alpha, and IL-6 were assessed.	oxygen-glucose	0-14	interleukin 6	Mus musculus	237-241
29715465-4	2018	Here, we found that miR-122 was decreased in mouse N2A neuroblastoma (N2A) cells after oxygen-glucose deprivation (OGD) and mouse brain after transient middle cerebral artery occlusion (MCAO).	oxygen-glucose	87-101	microRNA 122	Mus musculus	20-27
29976213-6	2018	METHODS: To explore this hypothesis, we utilized the specific blocking agent carbenoxolone (CBX) to inhibit the opening and internalization of connexin 43 channels in an in vitro model of oxygen-glucose deprivation/re-oxygenation (OGD/R), following IP.	oxygen-glucose	188-202	gap junction protein alpha 1	Homo sapiens	143-154
29909245-0	2018	Corrigendum to "Immunosuppressant cytoprotection correlates with HMGB1 suppression in primary astrocyte cultures exposed to combined oxygen-glucose deprivation" [Pharmacol.	oxygen-glucose	133-147	high mobility group box 1	Homo sapiens	65-70
29852169-5	2018	Using oxygen-glucose deprivation and reoxygenation (OGD/R) to create a cell model of hepatic I/R injury, we found that the mRNA and protein expression levels of TXNIP were upregulated in HL7702 cells exposed to OGD/R.	oxygen-glucose	6-20	thioredoxin interacting protein	Homo sapiens	161-166