PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 22901180-5 2012 In vivo, an animal study was set out in which BALB/C nude mice bearing tumors were treated with lentivirus mediated expression of Dm-dNKmut with the pyrimidine nucleoside analog brivudine (BVDU, (E)-5-(2-bromovinyl)-(2-deoxyuridine). brivudine 178-187 deoxyribonucleoside kinase Drosophila melanogaster 130-139 22804238-8 2012 One example, is brivudine that impairs HspB1 ability to recognize pathological protein substrates and appears as a promising anti-cancer drug. brivudine 16-25 heat shock protein family B (small) member 1 Homo sapiens 39-44 22273576-7 2012 These dCK mutants efficiently activate bromovinyl-deoxyuridine (BVdU), L-deoxythymidine (LdT), and L-deoxyuridine (LdU), which are otherwise not toxic to wild-type cells. brivudine 39-62 sticky Drosophila melanogaster 6-9 22273576-7 2012 These dCK mutants efficiently activate bromovinyl-deoxyuridine (BVdU), L-deoxythymidine (LdT), and L-deoxyuridine (LdU), which are otherwise not toxic to wild-type cells. brivudine 64-68 sticky Drosophila melanogaster 6-9 23254508-4 2013 Furthermore, BALB/C nude mice bearing tumors were treated with Dm-dNK mediated with the pyrimidine nucleoside analog, brivudine [BVDU, (E)-5-(2-bromovinyl)-2"-deoxyuridine]. brivudine 142-151 deoxyribonucleoside kinase Drosophila melanogaster 75-81 23254508-4 2013 Furthermore, BALB/C nude mice bearing tumors were treated with Dm-dNK mediated with the pyrimidine nucleoside analog, brivudine [BVDU, (E)-5-(2-bromovinyl)-2"-deoxyuridine]. brivudine 159-195 deoxyribonucleoside kinase Drosophila melanogaster 75-81 23000515-7 2013 SG500-dNK combined with the chemotherapeutics (E)-5-(2-bromovinyl)-2"-deoxyuridine (Bvdu) and 2",2"-difluoro-deoxycytidine (dFdC) resulted in synergistically enhanced cell killing and greatly improved antitumor efficacy in vitro or in breast xenografts in vivo. brivudine 46-82 deoxyribonucleoside kinase Drosophila melanogaster 6-9 22901180-5 2012 In vivo, an animal study was set out in which BALB/C nude mice bearing tumors were treated with lentivirus mediated expression of Dm-dNKmut with the pyrimidine nucleoside analog brivudine (BVDU, (E)-5-(2-bromovinyl)-(2-deoxyuridine). brivudine 195-231 deoxyribonucleoside kinase Drosophila melanogaster 130-139 12853888-1 2003 NB1011, a phosphoramidate derivative of (E)-5-(2-bromovinyl)-2"-deoxyuridine, is a novel anti-cancer agent that selectively targets tumor cells expressing high levels of thymidylate synthase (TS), an enzyme required for DNA biosynthesis. brivudine 40-76 thymidylate synthetase Homo sapiens 170-190 18600552-4 2008 BvdU phosphorylation by pure human TK2 and TK1 was tested here, and the ratio of BvdU phosphorylation by TK2/TK1 was 91 at 0.2 micro M but was 500 at 2.5 micro M. Therefore, for reliable measurement of TK2 activity higher BvdU concentration should be used. brivudine 0-4 thymidine kinase 2 Homo sapiens 35-38 18600552-4 2008 BvdU phosphorylation by pure human TK2 and TK1 was tested here, and the ratio of BvdU phosphorylation by TK2/TK1 was 91 at 0.2 micro M but was 500 at 2.5 micro M. Therefore, for reliable measurement of TK2 activity higher BvdU concentration should be used. brivudine 0-4 thymidine kinase 1 Homo sapiens 43-46 18600552-4 2008 BvdU phosphorylation by pure human TK2 and TK1 was tested here, and the ratio of BvdU phosphorylation by TK2/TK1 was 91 at 0.2 micro M but was 500 at 2.5 micro M. Therefore, for reliable measurement of TK2 activity higher BvdU concentration should be used. brivudine 81-85 thymidine kinase 2 Homo sapiens 35-38 18600552-4 2008 BvdU phosphorylation by pure human TK2 and TK1 was tested here, and the ratio of BvdU phosphorylation by TK2/TK1 was 91 at 0.2 micro M but was 500 at 2.5 micro M. Therefore, for reliable measurement of TK2 activity higher BvdU concentration should be used. brivudine 81-85 thymidine kinase 2 Homo sapiens 105-108 18600552-4 2008 BvdU phosphorylation by pure human TK2 and TK1 was tested here, and the ratio of BvdU phosphorylation by TK2/TK1 was 91 at 0.2 micro M but was 500 at 2.5 micro M. Therefore, for reliable measurement of TK2 activity higher BvdU concentration should be used. brivudine 81-85 thymidine kinase 1 Homo sapiens 109-112 18600552-4 2008 BvdU phosphorylation by pure human TK2 and TK1 was tested here, and the ratio of BvdU phosphorylation by TK2/TK1 was 91 at 0.2 micro M but was 500 at 2.5 micro M. Therefore, for reliable measurement of TK2 activity higher BvdU concentration should be used. brivudine 81-85 thymidine kinase 2 Homo sapiens 105-108 18384378-4 2008 In this study we present crystal structures of dNK complexed with four different nucleoside analogs (floxuridine, brivudine, zidovudine and zalcitabine) and relate them to the binding of substrate and feedback inhibitors. brivudine 114-123 deoxyribonucleoside kinase Drosophila melanogaster 47-50 18058549-2 2007 Herein, we report our preliminary analysis based on docking studies of (E)-5-(2-bromovinyl)-2"-deoxyuridine (BVdU) related aminoacyl phosphates with Hint1 and the effect of the amino acid moiety on the enzyme-substrate binding affinity. brivudine 71-107 histidine triad nucleotide binding protein 1 Homo sapiens 149-154 18058549-2 2007 Herein, we report our preliminary analysis based on docking studies of (E)-5-(2-bromovinyl)-2"-deoxyuridine (BVdU) related aminoacyl phosphates with Hint1 and the effect of the amino acid moiety on the enzyme-substrate binding affinity. brivudine 109-113 histidine triad nucleotide binding protein 1 Homo sapiens 149-154 16630572-2 2006 We tested the value of the thymidine analog (E)-5-(2-bromovinyl)-2"-deoxyuridine (BVDU) as a TK2-specific substrate. brivudine 44-80 thymidine kinase 2 Homo sapiens 93-96 16630572-2 2006 We tested the value of the thymidine analog (E)-5-(2-bromovinyl)-2"-deoxyuridine (BVDU) as a TK2-specific substrate. brivudine 82-86 thymidine kinase 2 Homo sapiens 93-96 12907246-9 2003 Of the tested analogs, only (E)-5-(2-bromovinyl)-2"-deoxyuridine was preferentially dephosphorylated by mitochondrial dNT-2. brivudine 28-64 spatzle 5 Drosophila melanogaster 118-123 21833720-0 2011 RP101 (brivudine) binds to heat shock protein HSP27 (HSPB1) and enhances survival in animals and pancreatic cancer patients. brivudine 7-16 heat shock protein family B (small) member 1 Homo sapiens 53-58 12626708-5 2003 In addition, Ag-dNK could also phosphorylate some medically interesting nucleoside analogs, like stavudine (D4T), 2-chloro-deoxyadenosine (CdA) and 5-bromo-vinyl-deoxyuridine (BVDU). brivudine 176-180 deoxyribonucleoside kinase Drosophila melanogaster 16-19 12527816-0 2003 Apoptosis induced by (E)-5-(2-bromovinyl)-2"-deoxyuridine in varicella zoster virus thymidine kinase-expressing cells is driven by activation of c-Jun/activator protein-1 and Fas ligand/caspase-8. brivudine 21-57 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 145-150 12527816-0 2003 Apoptosis induced by (E)-5-(2-bromovinyl)-2"-deoxyuridine in varicella zoster virus thymidine kinase-expressing cells is driven by activation of c-Jun/activator protein-1 and Fas ligand/caspase-8. brivudine 21-57 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 151-170 12527796-5 2003 However, whereas BVDU behaved as a noncompetitive inhibitor (alternative substrate) of TK-2 and HSV-1 TK with respect to ATP as the varying substrate, the novel tritylated enzyme inhibitors emerged as reversible purely uncompetitive inhibitors of these enzymes. brivudine 17-21 thymidine kinase 2 Homo sapiens 87-91 12527816-0 2003 Apoptosis induced by (E)-5-(2-bromovinyl)-2"-deoxyuridine in varicella zoster virus thymidine kinase-expressing cells is driven by activation of c-Jun/activator protein-1 and Fas ligand/caspase-8. brivudine 21-57 Fas ligand Homo sapiens 175-185 12527816-0 2003 Apoptosis induced by (E)-5-(2-bromovinyl)-2"-deoxyuridine in varicella zoster virus thymidine kinase-expressing cells is driven by activation of c-Jun/activator protein-1 and Fas ligand/caspase-8. brivudine 21-57 caspase 8 Homo sapiens 186-195 11455012-8 2001 These findings indicate that BVDU phosphorylated by Dm-dNK in transduced cancer cells may also induce bystander cell death in certain cell lines. brivudine 29-33 deoxyribonucleoside kinase Drosophila melanogaster 52-58 11809847-7 2002 Under the same experimental conditions, the anti-herpetic (E)-5-(2-bromovinyl)-2"-deoxyuridine (BVDU) derivative was efficiently converted to BVDU-MP and BVDU-DP by both VZV TK and HSV-1 TK and further, into BVDU-TP, by NDP kinase. brivudine 58-94 cytidine/uridine monophosphate kinase 2 Homo sapiens 220-230 11809847-7 2002 Under the same experimental conditions, the anti-herpetic (E)-5-(2-bromovinyl)-2"-deoxyuridine (BVDU) derivative was efficiently converted to BVDU-MP and BVDU-DP by both VZV TK and HSV-1 TK and further, into BVDU-TP, by NDP kinase. brivudine 96-100 cytidine/uridine monophosphate kinase 2 Homo sapiens 220-230 9359870-4 1997 We demonstrate that mt-TK does not show an absolute enantioselectivity, being able to recognize, although with lower efficiency, the L-enantiomers of thymidine, deoxycytidine and modified deoxyuridines, such as (E)-5-(2-bromovinyl)-2"-deoxyuridine and 5-iodo-2"-deoxyuridine. brivudine 211-247 thymidine kinase 2 Homo sapiens 20-25 11179438-4 2001 We show herein that tumor cells expressing elevated levels of TS are preferentially sensitive to NB1011, a phosphoramidate derivative of (E)-5-(2-bromovinyl)-2"-deoxyuridine. brivudine 137-173 thymidylate synthetase Homo sapiens 62-64 10993893-7 2000 The cells expressing Dm-dNK exhibited increased sensitivity to several cytotoxic nucleoside analogs, such as 1-beta-d-arabinofuranosylcytosine, 1-beta-d-arabinofuranosylthymine, (E)-5-(2-bromovinyl)-2"-deoxyuridine, 2-chloro-2"-deoxyadenosine, and 2",2"-difluorodeoxycytidine. brivudine 178-214 deoxyribonucleoside kinase Drosophila melanogaster 21-27 11354306-0 2000 Prevention of adriamycin-induced mdr1 gene amplification and expression in mouse leukemia cells by simultaneous treatment with the anti-recombinogen bromovinyldeoxyuridine. brivudine 149-171 malic enzyme complex, mitochondrial Mus musculus 33-37 11354306-1 2000 The anti-recombinogenic substance (E)-5-(2-bromovinyl)-2"-deoxyuridine (BVDU) was tested for its ability to prevent adriamycin-induced mdr1 gene amplification and expression in mouse leukemia cells in vitro. brivudine 34-70 malic enzyme complex, mitochondrial Mus musculus 135-139 11354306-1 2000 The anti-recombinogenic substance (E)-5-(2-bromovinyl)-2"-deoxyuridine (BVDU) was tested for its ability to prevent adriamycin-induced mdr1 gene amplification and expression in mouse leukemia cells in vitro. brivudine 72-76 malic enzyme complex, mitochondrial Mus musculus 135-139 2822932-6 1987 EAC also showed activity against a strain of HSV-1 resistant to (E)-5-(2-bromovinyl)-2"-deoxyuridine which has an alteration of the virus-induced thymidine kinase (TK). brivudine 64-100 involved in nucleotide metabolism Human alphaherpesvirus 1 146-162 8021603-0 1994 Analysis of the thymidine kinase of a herpes simplex virus type 1 isolate that exhibits resistance to (E)-5-(2-bromovinyl)-2"-deoxyuridine. brivudine 102-138 involved in nucleotide metabolism Human alphaherpesvirus 1 16-32 8384209-0 1993 Differential mechanism of cytostatic effect of (E)-5-(2-bromovinyl)-2"-deoxyuridine, 9-(1,3-dihydroxy-2-propoxymethyl)guanine, and other antiherpetic drugs on tumor cells transfected by the thymidine kinase gene of herpes simplex virus type 1 or type 2. brivudine 47-83 involved in nucleotide metabolism Human alphaherpesvirus 1 190-206 8384209-5 1993 Thymidylate synthase of the HSV TK gene-transfected FM3A cells appears to be the target enzyme for the cytostatic action of BVDU, but not FMAU, DHPG, or ACV. brivudine 124-128 thymidylate synthase Mus musculus 0-20 1650669-7 1991 These studies document that combinations of acyclic nucleoside analogs, ACV and DHPG, with IFN-alpha 2 resulted in synergistic anti-HSV activities in both Vero and human corneal stromal cells, while the pyrimidine analogs, TFT and BVdU, were not synergistic with IFN-alpha 2. brivudine 231-235 interferon alpha 2 Homo sapiens 91-102 6300257-2 1983 E-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil (BVaraU), E-5-(2-iodovinyl)-2"-deoxyuridine (IVDU), and E-5-(2-bromovinyl)-2"-deoxyuridine (BVDU) were the most effective. brivudine 143-147 Rho guanine nucleotide exchange factor 15 Homo sapiens 0-3 2823092-0 1987 Thymidylate synthase is the principal target enzyme for the cytostatic activity of (E)-5-(2-bromovinyl)-2"-deoxyuridine against murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 or type 2 thymidine kinase gene. brivudine 83-119 thymidylate synthase Mus musculus 0-20 6317706-3 1983 Sensitivity to E-5-(2-bromovinyl)-2"-deoxyuridine (BVDU) was also examined. brivudine 51-55 Rho guanine nucleotide exchange factor 15 Homo sapiens 15-18 2995273-2 1985 Compared to wild-type (WT) virus, all five of the dTK- mutants were highly resistant (greater than or equal to 500-fold) to BVdU and MMdU, moderately resistant to ACV (50- to 100-fold) and araT (10- to 20-fold), but not resistant to PAA. brivudine 124-128 Tachykinin Drosophila melanogaster 50-53 6319559-2 1983 It was found that the Kis for the 5-position analogues MMdU, [E]-5-(2-bromovinyl)deoxyuridine, bromodeoxyuridine and iododeoxyuridine were increased approximately three-to fivefold, suggesting that they were poorer substrates for the MMdUr dTK than for the wt dTK. brivudine 61-93 U2AF homology motif kinase 1 Homo sapiens 22-25 6319559-2 1983 It was found that the Kis for the 5-position analogues MMdU, [E]-5-(2-bromovinyl)deoxyuridine, bromodeoxyuridine and iododeoxyuridine were increased approximately three-to fivefold, suggesting that they were poorer substrates for the MMdUr dTK than for the wt dTK. brivudine 61-93 Tachykinin Drosophila melanogaster 240-243 6319559-2 1983 It was found that the Kis for the 5-position analogues MMdU, [E]-5-(2-bromovinyl)deoxyuridine, bromodeoxyuridine and iododeoxyuridine were increased approximately three-to fivefold, suggesting that they were poorer substrates for the MMdUr dTK than for the wt dTK. brivudine 61-93 Tachykinin Drosophila melanogaster 260-263 6312685-4 1983 This suggests that the thymidine analog, BVDU, can be phosphorylated in thymidine kinase-deficient cells by pathways other than the cellular or HSV-encoded thymidine kinase. brivudine 41-45 involved in nucleotide metabolism Human alphaherpesvirus 1 72-88 30539536-6 2019 We have developed a novel SGTC system based on viral vector-mediated delivery of an engineered variant of human deoxycytidine kinase (dCK), which is capable of phosphorylating uridine- and thymidine-based nucleoside analogues that are not substrates for wild-type dCK, such as bromovinyl deoxyuridine (BVdU) and L-deoxythymidine (LdT). brivudine 277-300 deoxycytidine kinase Homo sapiens 112-132 31826996-5 2020 By generating a recombinant KSHV mutant with an enzymatically inactive ORF21 protein, we show that the tyrosine kinase function of ORF21/TK is not required for the progression of the lytic replication in tissue culture but that it is essential for the phosphorylation and activation to toxic moieties of the antiviral drugs zidovudine and brivudine. brivudine 339-348 ORF21 Human gammaherpesvirus 8 131-136 30539536-6 2019 We have developed a novel SGTC system based on viral vector-mediated delivery of an engineered variant of human deoxycytidine kinase (dCK), which is capable of phosphorylating uridine- and thymidine-based nucleoside analogues that are not substrates for wild-type dCK, such as bromovinyl deoxyuridine (BVdU) and L-deoxythymidine (LdT). brivudine 277-300 Calcium/calmodulin-dependent protein kinase II Drosophila melanogaster 134-137 30539536-6 2019 We have developed a novel SGTC system based on viral vector-mediated delivery of an engineered variant of human deoxycytidine kinase (dCK), which is capable of phosphorylating uridine- and thymidine-based nucleoside analogues that are not substrates for wild-type dCK, such as bromovinyl deoxyuridine (BVdU) and L-deoxythymidine (LdT). brivudine 302-306 deoxycytidine kinase Homo sapiens 112-132 30539536-6 2019 We have developed a novel SGTC system based on viral vector-mediated delivery of an engineered variant of human deoxycytidine kinase (dCK), which is capable of phosphorylating uridine- and thymidine-based nucleoside analogues that are not substrates for wild-type dCK, such as bromovinyl deoxyuridine (BVdU) and L-deoxythymidine (LdT). brivudine 302-306 Calcium/calmodulin-dependent protein kinase II Drosophila melanogaster 134-137 30431011-1 2018 Ulixertinib (BVD-523) is a highly potent, selective, and reversible ERK1/2 inhibitor and is currently in clinical development for the treatment of advanced solid tumors. brivudine 13-16 mitogen-activated protein kinase 3 Homo sapiens 68-74 26630264-0 2015 Structure of the Varicella Zoster Virus Thymidylate Synthase Establishes Functional and Structural Similarities as the Human Enzyme and Potentiates Itself as a Target of Brivudine. brivudine 170-179 thymidylate synthase Human alphaherpesvirus 3 40-60