PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
35406202-2	2022	In this work, hydroxyphenolphthalein type polyetherketone grafted carboxy carbon nanotube (PEK-C-OH-g-MWCNTs-COOH) composites were prepared by esterification reaction.	mwcnts	102-108	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	91-94
32086094-8	2020	DPPC also led to a higher level of de novo lipogenesis regulator FASN in cells exposed to hydroxylated MWCNTs, as well as a higher level of p-chop and scavenger receptor MSR1 in cells exposed to carboxylated MWCNTs.	mwcnts	103-109	fatty acid synthase	Homo sapiens	65-69
32600691-1	2020	The aim of this research is to introduce a novel label free electrochemical immunosensor based on glassy carbon electrode (GCE) modified with carboxylated carbon nanotubes (COOH-MWCNTs)/polyaniline (PANI)/gold nanoparticles (AuNPs) for the detection of prostate specific antigen (PSA).	mwcnts	178-184	kallikrein related peptidase 3	Homo sapiens	253-278
32600691-1	2020	The aim of this research is to introduce a novel label free electrochemical immunosensor based on glassy carbon electrode (GCE) modified with carboxylated carbon nanotubes (COOH-MWCNTs)/polyaniline (PANI)/gold nanoparticles (AuNPs) for the detection of prostate specific antigen (PSA).	mwcnts	178-184	kallikrein related peptidase 3	Homo sapiens	280-283
29132433-9	2017	Colocalization of basal body marker CEP164 with gamma-tubulin during days 1-3 of ciliogenesis, as well as abundance of basal bodies up to day 14, were attenuated by treatment with MWCNTs.	mwcnts	180-186	centrosomal protein 164	Homo sapiens	36-42
31434956-6	2019	Therefore, MWCNTs exposure potentially dysregulates intestinal mir-35 and its direct target MAB-3, which may activate a protective intestinal response of nematodes against the MWCNTs toxicity.	mwcnts	11-17	mir-35	Caenorhabditis elegans	63-69
31434956-6	2019	Therefore, MWCNTs exposure potentially dysregulates intestinal mir-35 and its direct target MAB-3, which may activate a protective intestinal response of nematodes against the MWCNTs toxicity.	mwcnts	11-17	Protein male abnormal 3	Caenorhabditis elegans	92-97
30149914-2	2018	The present study elucidated the involvement of pro-inflammatory cytokines, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in carboxylated multi-walled carbon nanotubes (MWCNTs)-induced hepatotoxicity.	mwcnts	191-197	nitric oxide synthase 2	Rattus norvegicus	138-142
29440327-7	2018	RESULTS: We observed an upward trend in the concentration of endothelial damage marker intercellular adhesion molecule-1 (ICAM-1), with increasing exposure to MWCNTs in both phases.	mwcnts	159-165	intercellular adhesion molecule 1	Homo sapiens	87-120
29440327-7	2018	RESULTS: We observed an upward trend in the concentration of endothelial damage marker intercellular adhesion molecule-1 (ICAM-1), with increasing exposure to MWCNTs in both phases.	mwcnts	159-165	intercellular adhesion molecule 1	Homo sapiens	122-128
29282666-5	2018	Compared with E2 exposure, the E2-induced estrogenic responses (vtg1, vtg3, and esr1 genes) in zebrafish were markedly reduced to baseline by the presence of MWCNTs in most cases, indicating a strong protective effect.	mwcnts	158-164	estrogen receptor 1	Danio rerio	80-84
29929133-3	2018	The results showed that direct contact with high levels of MWCNTs induced cytotoxicity and modulated expression of genes associated with ER stress (HSPA5, DDIT3 and XBP-1s) and autophagy (BECN1 and ATG12) both in A549-THP-1 macrophages cultured in the upper chambers as well as HUVECs.	mwcnts	59-65	heat shock protein family A (Hsp70) member 5	Homo sapiens	148-153
29929133-3	2018	The results showed that direct contact with high levels of MWCNTs induced cytotoxicity and modulated expression of genes associated with ER stress (HSPA5, DDIT3 and XBP-1s) and autophagy (BECN1 and ATG12) both in A549-THP-1 macrophages cultured in the upper chambers as well as HUVECs.	mwcnts	59-65	DNA damage inducible transcript 3	Homo sapiens	155-160
29929133-3	2018	The results showed that direct contact with high levels of MWCNTs induced cytotoxicity and modulated expression of genes associated with ER stress (HSPA5, DDIT3 and XBP-1s) and autophagy (BECN1 and ATG12) both in A549-THP-1 macrophages cultured in the upper chambers as well as HUVECs.	mwcnts	59-65	beclin 1	Homo sapiens	188-193
29929133-3	2018	The results showed that direct contact with high levels of MWCNTs induced cytotoxicity and modulated expression of genes associated with ER stress (HSPA5, DDIT3 and XBP-1s) and autophagy (BECN1 and ATG12) both in A549-THP-1 macrophages cultured in the upper chambers as well as HUVECs.	mwcnts	59-65	autophagy related 12	Homo sapiens	198-203
29929133-3	2018	The results showed that direct contact with high levels of MWCNTs induced cytotoxicity and modulated expression of genes associated with ER stress (HSPA5, DDIT3 and XBP-1s) and autophagy (BECN1 and ATG12) both in A549-THP-1 macrophages cultured in the upper chambers as well as HUVECs.	mwcnts	59-65	GLI family zinc finger 2	Homo sapiens	218-223
27614682-2	2017	The significantly increased surface area due to the presence of MWCNTs led to a high immobilization density of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) activated anti-LCN2 capture antibodies (Ab).	mwcnts	64-70	lipocalin 2	Homo sapiens	179-183
27278808-15	2016	CONCLUSIONS: Pulmonary exposure to ZnO-coated MWCNTs produces a systemic acute phase response that involves the release of Zn(+2), lung epithelial growth arrest, and increased IL-6.	mwcnts	46-52	interleukin 6	Homo sapiens	176-180
28277982-7	2017	Significant differential protein expression was found in the following critical pathways: mTOR/eIF4/p70S6K signaling and Nrf-2 mediated oxidative stress response increased following exposure to Z-MWCNTs, interleukin-1 signaling increased following U-MWCNT exposure, and inhibition of angiogenesis by thrombospondin-1, oxidative phosphorylation, and mitochondrial dysfunction increased following A-MWCNT exposure.	mwcnts	196-202	mechanistic target of rapamycin kinase	Mus musculus	90-94
28277982-7	2017	Significant differential protein expression was found in the following critical pathways: mTOR/eIF4/p70S6K signaling and Nrf-2 mediated oxidative stress response increased following exposure to Z-MWCNTs, interleukin-1 signaling increased following U-MWCNT exposure, and inhibition of angiogenesis by thrombospondin-1, oxidative phosphorylation, and mitochondrial dysfunction increased following A-MWCNT exposure.	mwcnts	196-202	eukaryotic translation initiation factor 4A2	Mus musculus	95-99
28277982-7	2017	Significant differential protein expression was found in the following critical pathways: mTOR/eIF4/p70S6K signaling and Nrf-2 mediated oxidative stress response increased following exposure to Z-MWCNTs, interleukin-1 signaling increased following U-MWCNT exposure, and inhibition of angiogenesis by thrombospondin-1, oxidative phosphorylation, and mitochondrial dysfunction increased following A-MWCNT exposure.	mwcnts	196-202	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	100-106
28277982-7	2017	Significant differential protein expression was found in the following critical pathways: mTOR/eIF4/p70S6K signaling and Nrf-2 mediated oxidative stress response increased following exposure to Z-MWCNTs, interleukin-1 signaling increased following U-MWCNT exposure, and inhibition of angiogenesis by thrombospondin-1, oxidative phosphorylation, and mitochondrial dysfunction increased following A-MWCNT exposure.	mwcnts	196-202	nuclear factor, erythroid derived 2, like 2	Mus musculus	121-126
28277982-7	2017	Significant differential protein expression was found in the following critical pathways: mTOR/eIF4/p70S6K signaling and Nrf-2 mediated oxidative stress response increased following exposure to Z-MWCNTs, interleukin-1 signaling increased following U-MWCNT exposure, and inhibition of angiogenesis by thrombospondin-1, oxidative phosphorylation, and mitochondrial dysfunction increased following A-MWCNT exposure.	mwcnts	196-202	thrombospondin 1	Mus musculus	300-316
27573184-5	2016	RSKS-1, a putative ribosomal protein S6 kinase, acted as the target for mir-259 in regulating MWCNTs toxicity, and mutation of rsks-1 suppressed the susceptible property of mir-259 mutant to MWCNTs toxicity.	mwcnts	94-100	Ribosomal protein S6 kinase beta	Caenorhabditis elegans	0-6
27573184-5	2016	RSKS-1, a putative ribosomal protein S6 kinase, acted as the target for mir-259 in regulating MWCNTs toxicity, and mutation of rsks-1 suppressed the susceptible property of mir-259 mutant to MWCNTs toxicity.	mwcnts	94-100	Putative ribosomal protein S6 kinase alpha-1;Ribosomal protein S6 kinase	Caenorhabditis elegans	19-46
27573184-5	2016	RSKS-1, a putative ribosomal protein S6 kinase, acted as the target for mir-259 in regulating MWCNTs toxicity, and mutation of rsks-1 suppressed the susceptible property of mir-259 mutant to MWCNTs toxicity.	mwcnts	94-100	mir-259	Caenorhabditis elegans	72-79
27573184-5	2016	RSKS-1, a putative ribosomal protein S6 kinase, acted as the target for mir-259 in regulating MWCNTs toxicity, and mutation of rsks-1 suppressed the susceptible property of mir-259 mutant to MWCNTs toxicity.	mwcnts	191-197	Ribosomal protein S6 kinase beta	Caenorhabditis elegans	0-6
27573184-5	2016	RSKS-1, a putative ribosomal protein S6 kinase, acted as the target for mir-259 in regulating MWCNTs toxicity, and mutation of rsks-1 suppressed the susceptible property of mir-259 mutant to MWCNTs toxicity.	mwcnts	191-197	Putative ribosomal protein S6 kinase alpha-1;Ribosomal protein S6 kinase	Caenorhabditis elegans	19-46
27573184-5	2016	RSKS-1, a putative ribosomal protein S6 kinase, acted as the target for mir-259 in regulating MWCNTs toxicity, and mutation of rsks-1 suppressed the susceptible property of mir-259 mutant to MWCNTs toxicity.	mwcnts	191-197	mir-259	Caenorhabditis elegans	72-79
27573184-5	2016	RSKS-1, a putative ribosomal protein S6 kinase, acted as the target for mir-259 in regulating MWCNTs toxicity, and mutation of rsks-1 suppressed the susceptible property of mir-259 mutant to MWCNTs toxicity.	mwcnts	191-197	Ribosomal protein S6 kinase beta	Caenorhabditis elegans	127-133
27573184-5	2016	RSKS-1, a putative ribosomal protein S6 kinase, acted as the target for mir-259 in regulating MWCNTs toxicity, and mutation of rsks-1 suppressed the susceptible property of mir-259 mutant to MWCNTs toxicity.	mwcnts	191-197	mir-259	Caenorhabditis elegans	173-180
27573184-6	2016	Moreover, mir-259 functioned in pharynx-intestinal valve and RSKS-1 functioned in pharynx to regulate MWCNTs toxicity.	mwcnts	102-108	Ribosomal protein S6 kinase beta	Caenorhabditis elegans	61-67
26952453-5	2016	The poly-AzrS/MWCNTs/GCE exhibited an efficient electron mediating behavior together with well resolved peaks for dopamine, in 0.1 mol/dm(3) phosphate buffer (PBS) solution of pH 7.0.	mwcnts	14-20	aminomethyltransferase	Homo sapiens	21-24
25807359-8	2015	Stat1(-/-) mice displayed increased IL-13 in bronchoalveolar lavage fluid at 1 day compared with WT mice after treatment with OVA or OVA and MWCNTs.	mwcnts	141-147	signal transducer and activator of transcription 1	Mus musculus	0-5
26111538-0	2016	MWCNTs Induce ROS Generation, ERK Phosphorylation, and SOD-2 Expression in Human Mesothelial Cells.	mwcnts	0-6	mitogen-activated protein kinase 1	Homo sapiens	30-33
26111538-0	2016	MWCNTs Induce ROS Generation, ERK Phosphorylation, and SOD-2 Expression in Human Mesothelial Cells.	mwcnts	0-6	superoxide dismutase 2	Homo sapiens	55-60
25863377-2	2015	Briefly, Pd was electroplated on a multiwalled carbon nanotubes (MWCNTs)-modified Au electrode, and the GOx-PABA-PdNPs bionanocomposite was prepared on the Pd(plate)/MWCNTs/Au electrode through the chemical oxidation of a GOx-3-anilineboronic acid adduct by Na2PdCl4, followed by electrode-modification with an outer-layer chitosan (CS) film.	mwcnts	65-71	hydroxyacid oxidase 1	Homo sapiens	104-107
26091108-8	2015	RESULTS: Priming of THP-1 macrophages with LPS increased pro-IL-1beta and subsequent exposure to MWCNTs induced IL-1beta secretion.	mwcnts	97-103	interleukin 1 beta	Mus musculus	112-120
26091108-15	2015	CONCLUSIONS: These data indicate that Th2 cytokines suppress MWCNT-induced inflammasome activation via STAT6-dependent down-regulation of pro-caspase-1 and suggest that suppression of inflammasome activation and IL-1beta by an allergic lung microenvironment is a mechanism through which MWCNTs exacerbate allergen-induced airway fibrosis.	mwcnts	287-293	signal transducer and activator of transcription 6	Mus musculus	103-108
24039418-4	2013	Treatment of 1.4E7 cells for 30 minutes with NA-MWCNTs at concentrations ranging from 1 mg/L to 20 mg/L resulted in significantly increased insulin release (0.18 +- 0.026 ng/mL for 1 mg/L, 0.21 +- 0.024 ng/mL for 5 mg/L, and 0.27 +- 0.028 ng/mL for 20 mg/L).	mwcnts	48-54	insulin	Homo sapiens	140-147
25001191-7	2014	The optimum temperature for poly(AN-co-OVSEG)/MWCNTs nanofibers increased from 25 C to 45 C compared to free CAT.	mwcnts	46-52	catalase	Homo sapiens	109-112
23642096-8	2013	Concentrations of certain prostanoids (prostaglandin D2 and thromboxane B2) were enhanced by OVA or MWCNTs in COX-2(-/-) mice.	mwcnts	100-106	prostaglandin-endoperoxide synthase 2	Mus musculus	110-115
26504962-2	2015	The electrocatalytic properties of GCE modified with MWCNTs in the presence of 4-chlorocatechol toward the electrocatalytic oxidation of NAC and Trp was studied using cyclic voltammetry (CV), double-step potential chronoamperometry and differential pulse voltammetry (DPV).	mwcnts	53-59	X-linked Kx blood group	Homo sapiens	137-140
23755279-6	2013	Additionally, MWCNTs-PEG induced less generation of reactive oxygen species (ROS) involving less activation of NADPH oxidase compared with MWCNTs-COOH, as evidenced by membrane translocation of p47(phox) and p67(phox) in macrophages.	mwcnts	14-20	pleckstrin	Homo sapiens	194-203
23755279-6	2013	Additionally, MWCNTs-PEG induced less generation of reactive oxygen species (ROS) involving less activation of NADPH oxidase compared with MWCNTs-COOH, as evidenced by membrane translocation of p47(phox) and p67(phox) in macrophages.	mwcnts	14-20	CD33 molecule	Homo sapiens	208-211
23755279-6	2013	Additionally, MWCNTs-PEG induced less generation of reactive oxygen species (ROS) involving less activation of NADPH oxidase compared with MWCNTs-COOH, as evidenced by membrane translocation of p47(phox) and p67(phox) in macrophages.	mwcnts	14-20	pleckstrin	Homo sapiens	198-202
23646722-2	2013	Herein, nearly monodisperse CoFe2O4 nanoparticles have been deposited on multi-walled carbon nanotubes (MWCNTs) by high-temperature hydrolysis and inorganic polymerization of ionic Co(II) and Fe(III) salts and MWCNTs in a polyol solution.	mwcnts	104-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-187
22373798-7	2012	MWCNTs significantly induced the expression of inducible nitric oxide synthase (iNOS) for 24 h (p<0.05).	mwcnts	0-6	nitric oxide synthase 2	Homo sapiens	47-78
22373798-7	2012	MWCNTs significantly induced the expression of inducible nitric oxide synthase (iNOS) for 24 h (p<0.05).	mwcnts	0-6	nitric oxide synthase 2	Homo sapiens	80-84
21576788-4	2011	A decrease in the expression of transforming growth factor-beta (TGFbeta) was observed in the mice treated with MWCNTs, whereas the suppression of the expression of both TGFbeta and IL-10 was observed in mice that had been both treated and immunized.	mwcnts	112-118	transforming growth factor, beta 1	Mus musculus	65-72
22755027-5	2012	Treatment with MWCNTs induced apoptosis in osteoclasts as characterized by nuclear condensation, DNA fragmentation, caspase-3 activation and poly(ADP-ribose) polymerase (PARP) cleavage, but did not decrease the cell viability of the osteoblast-like cell line MC3T3-E1.	mwcnts	15-21	caspase 3	Mus musculus	116-125
22755027-5	2012	Treatment with MWCNTs induced apoptosis in osteoclasts as characterized by nuclear condensation, DNA fragmentation, caspase-3 activation and poly(ADP-ribose) polymerase (PARP) cleavage, but did not decrease the cell viability of the osteoblast-like cell line MC3T3-E1.	mwcnts	15-21	poly (ADP-ribose) polymerase family, member 1	Mus musculus	141-168
22755027-5	2012	Treatment with MWCNTs induced apoptosis in osteoclasts as characterized by nuclear condensation, DNA fragmentation, caspase-3 activation and poly(ADP-ribose) polymerase (PARP) cleavage, but did not decrease the cell viability of the osteoblast-like cell line MC3T3-E1.	mwcnts	15-21	poly (ADP-ribose) polymerase family, member 1	Mus musculus	170-174
22755027-7	2012	MWCNTs-induced apoptosis in osteoclasts was inhibited both by cyclosporin A, a blocker of the mitochondrial permeability transition pore, and by DEVD-CHO, a cell-permeable inhibitor of caspase-3.	mwcnts	0-6	caspase 3	Mus musculus	185-194
20702080-2	2010	Recombinant pyrroloquinoline quinone (PQQ) dependent glucose dehydrogenase (GDH) is covalently coupled to a PQQ-layer which is adsorbed onto thiol-modified MWCNTs at a gold electrode.	mwcnts	156-162	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	53-74
21296185-8	2011	On the other hand, the free radical scavenger N-acetyl-l-cysteine (NAC) preincubation can inhibit the cytotoxic and genotoxic effects of MWCNTs.	mwcnts	137-143	X-linked Kx blood group	Homo sapiens	67-70
20702080-2	2010	Recombinant pyrroloquinoline quinone (PQQ) dependent glucose dehydrogenase (GDH) is covalently coupled to a PQQ-layer which is adsorbed onto thiol-modified MWCNTs at a gold electrode.	mwcnts	156-162	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	76-79
17868683-5	2007	The Pb(II) in the form of PbO, Pb(OH)(2), and PbCO(3) adsorbed on the surface of the acidified MWCNTs is only 3.4% of the total Pb(II) adsorption capacity.	mwcnts	95-101	submaxillary gland androgen regulated protein 3B	Homo sapiens	4-10
20438087-5	2010	The adsorption of Pb(II) on MWCNTs/iron oxides/CD was found to be dependent on pH, and the adsorption of 1-naphthol was found to be independent of pH.	mwcnts	28-34	submaxillary gland androgen regulated protein 3B	Homo sapiens	18-24