PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
19965522-8	2009	Therefore, HP-NAP may be associated with the pathology of anti-AQP4 antibody-related neural damage in MS/NMO patients.	hp-nap	11-17	aquaporin 4	Homo sapiens	63-67
34768994-4	2021	HP-NAP-induced ROS production in ATRA-induced differentiated HL-60 cells is mediated by the PTX-sensitive heterotrimeric G protein-dependent activation of extracellular signal-regulated kinase 1/2 and p38-mitogen-activated protein kinase, which is consistent with the findings reported for human neutrophils.	hp-nap	0-6	mitogen-activated protein kinase 3	Homo sapiens	155-196
34768994-4	2021	HP-NAP-induced ROS production in ATRA-induced differentiated HL-60 cells is mediated by the PTX-sensitive heterotrimeric G protein-dependent activation of extracellular signal-regulated kinase 1/2 and p38-mitogen-activated protein kinase, which is consistent with the findings reported for human neutrophils.	hp-nap	0-6	mitogen-activated protein kinase 14	Homo sapiens	201-237
32762390-6	2020	The secretion of IgE, IL-4 and IFN-gamma were measured by enzyme linked immunosorbent assay (ELISA).Results: Treatment with HP-NAP successfully alleviated the symptoms of AD, such as erythema, horny substance, and swelling.	hp-nap	124-130	interleukin 4	Mus musculus	22-26
32762390-6	2020	The secretion of IgE, IL-4 and IFN-gamma were measured by enzyme linked immunosorbent assay (ELISA).Results: Treatment with HP-NAP successfully alleviated the symptoms of AD, such as erythema, horny substance, and swelling.	hp-nap	124-130	interferon gamma	Mus musculus	31-40
32762390-8	2020	The secretion of IgE and IL-4 were significantly attenuated following treatment with HP-NAP.	hp-nap	85-91	interleukin 4	Mus musculus	25-29
22522462-6	2012	It is of note that HP-NAP-treated tumors show also a reduced vascularization due to the anti-angiogenic activity of IFN-gamma induced by HP-NAP.	hp-nap	19-25	interferon gamma	Homo sapiens	116-125
22522462-6	2012	It is of note that HP-NAP-treated tumors show also a reduced vascularization due to the anti-angiogenic activity of IFN-gamma induced by HP-NAP.	hp-nap	137-143	interferon gamma	Homo sapiens	116-125
26375619-2	2015	It has been reported that HP-NAP induces degranulation and interleukin-6 (IL-6) secretion of rat peritoneal mast cells.	hp-nap	26-32	interleukin 6	Rattus norvegicus	59-72
26375619-2	2015	It has been reported that HP-NAP induces degranulation and interleukin-6 (IL-6) secretion of rat peritoneal mast cells.	hp-nap	26-32	interleukin 6	Rattus norvegicus	74-78
26375619-4	2015	Here, we show that HP-NAP activates human mast cell line-1 (HMC-1) cells to secrete histamine and IL-6.	hp-nap	19-25	interleukin 6	Homo sapiens	98-102
26375619-6	2015	Moreover, HP-NAP induces PTX-sensitive G protein-mediated activation of extracellular signal-regulated kinase 1/2 (ERK1/2), p38-mitogen-activated protein kinase (p38 MAPK), and Akt in HMC-1 cells.	hp-nap	10-16	mitogen-activated protein kinase 1	Homo sapiens	72-113
26375619-6	2015	Moreover, HP-NAP induces PTX-sensitive G protein-mediated activation of extracellular signal-regulated kinase 1/2 (ERK1/2), p38-mitogen-activated protein kinase (p38 MAPK), and Akt in HMC-1 cells.	hp-nap	10-16	mitogen-activated protein kinase 3	Homo sapiens	115-121
26375619-6	2015	Moreover, HP-NAP induces PTX-sensitive G protein-mediated activation of extracellular signal-regulated kinase 1/2 (ERK1/2), p38-mitogen-activated protein kinase (p38 MAPK), and Akt in HMC-1 cells.	hp-nap	10-16	mitogen-activated protein kinase 14	Homo sapiens	124-160
26375619-6	2015	Moreover, HP-NAP induces PTX-sensitive G protein-mediated activation of extracellular signal-regulated kinase 1/2 (ERK1/2), p38-mitogen-activated protein kinase (p38 MAPK), and Akt in HMC-1 cells.	hp-nap	10-16	mitogen-activated protein kinase 14	Homo sapiens	162-170
26375619-6	2015	Moreover, HP-NAP induces PTX-sensitive G protein-mediated activation of extracellular signal-regulated kinase 1/2 (ERK1/2), p38-mitogen-activated protein kinase (p38 MAPK), and Akt in HMC-1 cells.	hp-nap	10-16	AKT serine/threonine kinase 1	Homo sapiens	177-180
26375619-7	2015	Inhibition of ERK1/2, p38 MAPK, or phosphatidylinositol 3-kinase (PI3K) suppresses HP-NAP-induced release of histamine and IL-6 from HMC-1 cells.	hp-nap	83-89	mitogen-activated protein kinase 3	Homo sapiens	14-20
26375619-7	2015	Inhibition of ERK1/2, p38 MAPK, or phosphatidylinositol 3-kinase (PI3K) suppresses HP-NAP-induced release of histamine and IL-6 from HMC-1 cells.	hp-nap	83-89	interleukin 6	Homo sapiens	123-127
26375619-8	2015	Thus, the activation of HMC-1 cells by HP-NAP is through Gi-linked G protein-coupled receptor-mediated MAPKs and PI3K/Akt pathways.	hp-nap	39-45	AKT serine/threonine kinase 1	Homo sapiens	118-121
21833592-0	2012	HP-NAP inhibits the growth of bladder cancer in mice by activating a cytotoxic Th1 response.	hp-nap	0-6	negative elongation factor complex member C/D, Th1l	Mus musculus	79-82
21833592-10	2012	Noteworthy, HP-NAP-treated tumours show also a reduced vascularization due to the anti-angiogenic activity of IFN-gamma induced by HP-NAP.	hp-nap	12-18	interferon gamma	Mus musculus	110-119
18823946-4	2008	In this study, we evaluated whether HP-NAP could promote MPO release from human neutrophils.	hp-nap	36-42	myeloperoxidase	Homo sapiens	57-60
19452583-7	2009	HP-NAP could slightly up-regulate IL-8 production in gastric epithelial cell lines but had no effect on GRO(alpha) production.	hp-nap	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
19212203-4	2009	PATIENTS AND METHODS: The in-vivo effect of AGPs/CMG under the presence of HP-NAP in neutrophil activation was investigated in five H. pylori-infected patients and three healthy volunteers who received 1 g daily consumption of CMG for 2 months.	hp-nap	75-81	alkylglycerone phosphate synthase	Homo sapiens	44-48
19212203-11	2009	CONCLUSION: AGPs/CMG inhibit neutrophil activation in the presence of HP-NAP, playing a crucial role in H. pylori-associated pathologies in gastric mucosa.	hp-nap	70-76	alkylglycerone phosphate synthase	Homo sapiens	12-16
18823946-7	2008	In addition to stimulating the production of reactive oxygen species, HP-NAP is able to induce the secretion of MPO in human neutrophils.	hp-nap	70-76	myeloperoxidase	Homo sapiens	112-115
18823946-8	2008	The increased MPO release from neutrophils induced by HP-NAP may be related to the pathogenesis of H. pylori-associated gastritis.	hp-nap	54-60	myeloperoxidase	Homo sapiens	14-17
18804852-7	2008	The addition of anti-Toll-like receptor 2 antibody abrogated the anti-T(H)2/pro-T(H)1 activity of HP-NAP.	hp-nap	98-104	toll-like receptor 2	Mus musculus	21-41
18671823-2	2008	This study was aimed to assess whether systemic/intraperitoneal and/or mucosal HP-NAP administration inhibited the Th2-mediated bronchial inflammation using a mouse model of allergic asthma induced by inhaled ovalbumin (OVA).	hp-nap	79-85	heart and neural crest derivatives expressed 2	Mus musculus	115-118
18671823-6	2008	Mucosal administration of HP-NAP was equally successful as the systemic delivery in reducing eosinophilia, IgE and Th2 cytokine levels in bronchoalveolar lavage.	hp-nap	26-32	heart and neural crest derivatives expressed 2	Mus musculus	115-118
17237377-5	2007	We also show that HP-NAP stimulates human PMNs to synthesize and release a number of chemokines, including CXCL8, CCL3, and CCL4.	hp-nap	18-24	C-X-C motif chemokine ligand 8	Homo sapiens	107-112
17237377-5	2007	We also show that HP-NAP stimulates human PMNs to synthesize and release a number of chemokines, including CXCL8, CCL3, and CCL4.	hp-nap	18-24	C-C motif chemokine ligand 3	Homo sapiens	114-118
17237377-5	2007	We also show that HP-NAP stimulates human PMNs to synthesize and release a number of chemokines, including CXCL8, CCL3, and CCL4.	hp-nap	18-24	C-C motif chemokine ligand 4	Homo sapiens	124-128
16543949-3	2006	Addition in culture of HP-NAP, as an immune modulator, to antigen-induced T cell lines resulted in a remarkable increase in the number of IFN-gamma-producing T cells and decrease of IL-4-secreting cells, thus shifting the cytokine profile of antigen-activated human T cells from Th2 to a Th1 cytotoxic phenotype.	hp-nap	23-29	interferon gamma	Homo sapiens	138-147
16543949-3	2006	Addition in culture of HP-NAP, as an immune modulator, to antigen-induced T cell lines resulted in a remarkable increase in the number of IFN-gamma-producing T cells and decrease of IL-4-secreting cells, thus shifting the cytokine profile of antigen-activated human T cells from Th2 to a Th1 cytotoxic phenotype.	hp-nap	23-29	interleukin 4	Homo sapiens	182-186
11237830-2	2001	The effect of HP-NAP on the production of tissue factor (TF), plasminogen activator inhibitor-2 (PAI-2), and urokinase-type plasminogen activator (u-PA) by human blood mononuclear cells (MNC) was evaluated by using functional and immunological assays and mRNA analysis.	hp-nap	14-20	coagulation factor III, tissue factor	Homo sapiens	42-55
11237830-2	2001	The effect of HP-NAP on the production of tissue factor (TF), plasminogen activator inhibitor-2 (PAI-2), and urokinase-type plasminogen activator (u-PA) by human blood mononuclear cells (MNC) was evaluated by using functional and immunological assays and mRNA analysis.	hp-nap	14-20	plasminogen activator, urokinase	Homo sapiens	147-151
17521355-3	2007	HP-NAP, a TLR2 agonist, is an immune modulator able to induce the expression of interleukin-12 (IL-12) and IL-23 by human neutrophils and monocytes.	hp-nap	0-6	toll like receptor 2	Homo sapiens	10-14
17521355-3	2007	HP-NAP, a TLR2 agonist, is an immune modulator able to induce the expression of interleukin-12 (IL-12) and IL-23 by human neutrophils and monocytes.	hp-nap	0-6	interleukin 23 subunit alpha	Homo sapiens	107-112