PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 19965522-8 2009 Therefore, HP-NAP may be associated with the pathology of anti-AQP4 antibody-related neural damage in MS/NMO patients. hp-nap 11-17 aquaporin 4 Homo sapiens 63-67 34768994-4 2021 HP-NAP-induced ROS production in ATRA-induced differentiated HL-60 cells is mediated by the PTX-sensitive heterotrimeric G protein-dependent activation of extracellular signal-regulated kinase 1/2 and p38-mitogen-activated protein kinase, which is consistent with the findings reported for human neutrophils. hp-nap 0-6 mitogen-activated protein kinase 3 Homo sapiens 155-196 34768994-4 2021 HP-NAP-induced ROS production in ATRA-induced differentiated HL-60 cells is mediated by the PTX-sensitive heterotrimeric G protein-dependent activation of extracellular signal-regulated kinase 1/2 and p38-mitogen-activated protein kinase, which is consistent with the findings reported for human neutrophils. hp-nap 0-6 mitogen-activated protein kinase 14 Homo sapiens 201-237 32762390-6 2020 The secretion of IgE, IL-4 and IFN-gamma were measured by enzyme linked immunosorbent assay (ELISA).Results: Treatment with HP-NAP successfully alleviated the symptoms of AD, such as erythema, horny substance, and swelling. hp-nap 124-130 interleukin 4 Mus musculus 22-26 32762390-6 2020 The secretion of IgE, IL-4 and IFN-gamma were measured by enzyme linked immunosorbent assay (ELISA).Results: Treatment with HP-NAP successfully alleviated the symptoms of AD, such as erythema, horny substance, and swelling. hp-nap 124-130 interferon gamma Mus musculus 31-40 32762390-8 2020 The secretion of IgE and IL-4 were significantly attenuated following treatment with HP-NAP. hp-nap 85-91 interleukin 4 Mus musculus 25-29 22522462-6 2012 It is of note that HP-NAP-treated tumors show also a reduced vascularization due to the anti-angiogenic activity of IFN-gamma induced by HP-NAP. hp-nap 19-25 interferon gamma Homo sapiens 116-125 22522462-6 2012 It is of note that HP-NAP-treated tumors show also a reduced vascularization due to the anti-angiogenic activity of IFN-gamma induced by HP-NAP. hp-nap 137-143 interferon gamma Homo sapiens 116-125 26375619-2 2015 It has been reported that HP-NAP induces degranulation and interleukin-6 (IL-6) secretion of rat peritoneal mast cells. hp-nap 26-32 interleukin 6 Rattus norvegicus 59-72 26375619-2 2015 It has been reported that HP-NAP induces degranulation and interleukin-6 (IL-6) secretion of rat peritoneal mast cells. hp-nap 26-32 interleukin 6 Rattus norvegicus 74-78 26375619-4 2015 Here, we show that HP-NAP activates human mast cell line-1 (HMC-1) cells to secrete histamine and IL-6. hp-nap 19-25 interleukin 6 Homo sapiens 98-102 26375619-6 2015 Moreover, HP-NAP induces PTX-sensitive G protein-mediated activation of extracellular signal-regulated kinase 1/2 (ERK1/2), p38-mitogen-activated protein kinase (p38 MAPK), and Akt in HMC-1 cells. hp-nap 10-16 mitogen-activated protein kinase 1 Homo sapiens 72-113 26375619-6 2015 Moreover, HP-NAP induces PTX-sensitive G protein-mediated activation of extracellular signal-regulated kinase 1/2 (ERK1/2), p38-mitogen-activated protein kinase (p38 MAPK), and Akt in HMC-1 cells. hp-nap 10-16 mitogen-activated protein kinase 3 Homo sapiens 115-121 26375619-6 2015 Moreover, HP-NAP induces PTX-sensitive G protein-mediated activation of extracellular signal-regulated kinase 1/2 (ERK1/2), p38-mitogen-activated protein kinase (p38 MAPK), and Akt in HMC-1 cells. hp-nap 10-16 mitogen-activated protein kinase 14 Homo sapiens 124-160 26375619-6 2015 Moreover, HP-NAP induces PTX-sensitive G protein-mediated activation of extracellular signal-regulated kinase 1/2 (ERK1/2), p38-mitogen-activated protein kinase (p38 MAPK), and Akt in HMC-1 cells. hp-nap 10-16 mitogen-activated protein kinase 14 Homo sapiens 162-170 26375619-6 2015 Moreover, HP-NAP induces PTX-sensitive G protein-mediated activation of extracellular signal-regulated kinase 1/2 (ERK1/2), p38-mitogen-activated protein kinase (p38 MAPK), and Akt in HMC-1 cells. hp-nap 10-16 AKT serine/threonine kinase 1 Homo sapiens 177-180 26375619-7 2015 Inhibition of ERK1/2, p38 MAPK, or phosphatidylinositol 3-kinase (PI3K) suppresses HP-NAP-induced release of histamine and IL-6 from HMC-1 cells. hp-nap 83-89 mitogen-activated protein kinase 3 Homo sapiens 14-20 26375619-7 2015 Inhibition of ERK1/2, p38 MAPK, or phosphatidylinositol 3-kinase (PI3K) suppresses HP-NAP-induced release of histamine and IL-6 from HMC-1 cells. hp-nap 83-89 interleukin 6 Homo sapiens 123-127 26375619-8 2015 Thus, the activation of HMC-1 cells by HP-NAP is through Gi-linked G protein-coupled receptor-mediated MAPKs and PI3K/Akt pathways. hp-nap 39-45 AKT serine/threonine kinase 1 Homo sapiens 118-121 21833592-0 2012 HP-NAP inhibits the growth of bladder cancer in mice by activating a cytotoxic Th1 response. hp-nap 0-6 negative elongation factor complex member C/D, Th1l Mus musculus 79-82 21833592-10 2012 Noteworthy, HP-NAP-treated tumours show also a reduced vascularization due to the anti-angiogenic activity of IFN-gamma induced by HP-NAP. hp-nap 12-18 interferon gamma Mus musculus 110-119 18823946-4 2008 In this study, we evaluated whether HP-NAP could promote MPO release from human neutrophils. hp-nap 36-42 myeloperoxidase Homo sapiens 57-60 19452583-7 2009 HP-NAP could slightly up-regulate IL-8 production in gastric epithelial cell lines but had no effect on GRO(alpha) production. hp-nap 0-6 C-X-C motif chemokine ligand 8 Homo sapiens 34-38 19212203-4 2009 PATIENTS AND METHODS: The in-vivo effect of AGPs/CMG under the presence of HP-NAP in neutrophil activation was investigated in five H. pylori-infected patients and three healthy volunteers who received 1 g daily consumption of CMG for 2 months. hp-nap 75-81 alkylglycerone phosphate synthase Homo sapiens 44-48 19212203-11 2009 CONCLUSION: AGPs/CMG inhibit neutrophil activation in the presence of HP-NAP, playing a crucial role in H. pylori-associated pathologies in gastric mucosa. hp-nap 70-76 alkylglycerone phosphate synthase Homo sapiens 12-16 18823946-7 2008 In addition to stimulating the production of reactive oxygen species, HP-NAP is able to induce the secretion of MPO in human neutrophils. hp-nap 70-76 myeloperoxidase Homo sapiens 112-115 18823946-8 2008 The increased MPO release from neutrophils induced by HP-NAP may be related to the pathogenesis of H. pylori-associated gastritis. hp-nap 54-60 myeloperoxidase Homo sapiens 14-17 18804852-7 2008 The addition of anti-Toll-like receptor 2 antibody abrogated the anti-T(H)2/pro-T(H)1 activity of HP-NAP. hp-nap 98-104 toll-like receptor 2 Mus musculus 21-41 18671823-2 2008 This study was aimed to assess whether systemic/intraperitoneal and/or mucosal HP-NAP administration inhibited the Th2-mediated bronchial inflammation using a mouse model of allergic asthma induced by inhaled ovalbumin (OVA). hp-nap 79-85 heart and neural crest derivatives expressed 2 Mus musculus 115-118 18671823-6 2008 Mucosal administration of HP-NAP was equally successful as the systemic delivery in reducing eosinophilia, IgE and Th2 cytokine levels in bronchoalveolar lavage. hp-nap 26-32 heart and neural crest derivatives expressed 2 Mus musculus 115-118 17237377-5 2007 We also show that HP-NAP stimulates human PMNs to synthesize and release a number of chemokines, including CXCL8, CCL3, and CCL4. hp-nap 18-24 C-X-C motif chemokine ligand 8 Homo sapiens 107-112 17237377-5 2007 We also show that HP-NAP stimulates human PMNs to synthesize and release a number of chemokines, including CXCL8, CCL3, and CCL4. hp-nap 18-24 C-C motif chemokine ligand 3 Homo sapiens 114-118 17237377-5 2007 We also show that HP-NAP stimulates human PMNs to synthesize and release a number of chemokines, including CXCL8, CCL3, and CCL4. hp-nap 18-24 C-C motif chemokine ligand 4 Homo sapiens 124-128 16543949-3 2006 Addition in culture of HP-NAP, as an immune modulator, to antigen-induced T cell lines resulted in a remarkable increase in the number of IFN-gamma-producing T cells and decrease of IL-4-secreting cells, thus shifting the cytokine profile of antigen-activated human T cells from Th2 to a Th1 cytotoxic phenotype. hp-nap 23-29 interferon gamma Homo sapiens 138-147 16543949-3 2006 Addition in culture of HP-NAP, as an immune modulator, to antigen-induced T cell lines resulted in a remarkable increase in the number of IFN-gamma-producing T cells and decrease of IL-4-secreting cells, thus shifting the cytokine profile of antigen-activated human T cells from Th2 to a Th1 cytotoxic phenotype. hp-nap 23-29 interleukin 4 Homo sapiens 182-186 11237830-2 2001 The effect of HP-NAP on the production of tissue factor (TF), plasminogen activator inhibitor-2 (PAI-2), and urokinase-type plasminogen activator (u-PA) by human blood mononuclear cells (MNC) was evaluated by using functional and immunological assays and mRNA analysis. hp-nap 14-20 coagulation factor III, tissue factor Homo sapiens 42-55 11237830-2 2001 The effect of HP-NAP on the production of tissue factor (TF), plasminogen activator inhibitor-2 (PAI-2), and urokinase-type plasminogen activator (u-PA) by human blood mononuclear cells (MNC) was evaluated by using functional and immunological assays and mRNA analysis. hp-nap 14-20 plasminogen activator, urokinase Homo sapiens 147-151 17521355-3 2007 HP-NAP, a TLR2 agonist, is an immune modulator able to induce the expression of interleukin-12 (IL-12) and IL-23 by human neutrophils and monocytes. hp-nap 0-6 toll like receptor 2 Homo sapiens 10-14 17521355-3 2007 HP-NAP, a TLR2 agonist, is an immune modulator able to induce the expression of interleukin-12 (IL-12) and IL-23 by human neutrophils and monocytes. hp-nap 0-6 interleukin 23 subunit alpha Homo sapiens 107-112