PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 33739971-14 2021 These wupA features are comparable to those of dpp, the only other HL studied to some extent, and reveal a scenario of strict dosage dependence with implications for gene expression regulation and splitting. dipalmitoylphosphatidylserine 47-50 wings up A Drosophila melanogaster 6-10 2731665-6 1989 Both DPP and DPrP were toxic to the reproductive system as evidenced by a complete inhibition of fertility at 1.25 and 2.5% DPP or 5.0% DPrP, and reduced fertility (litters/pair and live pups/litter, 0.5% DPP; live pups/litter, 2.5% DPrP). dipalmitoylphosphatidylserine 5-8 prolactin family 8, subfamily a, member 2 Mus musculus 136-140 2731665-6 1989 Both DPP and DPrP were toxic to the reproductive system as evidenced by a complete inhibition of fertility at 1.25 and 2.5% DPP or 5.0% DPrP, and reduced fertility (litters/pair and live pups/litter, 0.5% DPP; live pups/litter, 2.5% DPrP). dipalmitoylphosphatidylserine 5-8 prolactin family 8, subfamily a, member 2 Mus musculus 136-140 2731665-6 1989 Both DPP and DPrP were toxic to the reproductive system as evidenced by a complete inhibition of fertility at 1.25 and 2.5% DPP or 5.0% DPrP, and reduced fertility (litters/pair and live pups/litter, 0.5% DPP; live pups/litter, 2.5% DPrP). dipalmitoylphosphatidylserine 124-127 prolactin family 8, subfamily a, member 2 Mus musculus 13-17 2731665-6 1989 Both DPP and DPrP were toxic to the reproductive system as evidenced by a complete inhibition of fertility at 1.25 and 2.5% DPP or 5.0% DPrP, and reduced fertility (litters/pair and live pups/litter, 0.5% DPP; live pups/litter, 2.5% DPrP). dipalmitoylphosphatidylserine 124-127 prolactin family 8, subfamily a, member 2 Mus musculus 13-17 3169134-5 1988 At the highest concentration employed (2.5 x 10(-5) M), Sm, DPPC, and DPPS maintained between 45 and 65% of the plateau survival with CG8 (maximally supported by ciliary neuronotrophic factor (CNTF], DRG8, and DRG10 neurons, and 30 to 40% with SG11 neurons. dipalmitoylphosphatidylserine 70-74 ciliary neurotrophic factor Gallus gallus 193-198 3917963-3 1985 We found that shortvein resides distal to Hin-d and dpp within the same polytene chromosome doublet, 22F1-2. dipalmitoylphosphatidylserine 52-55 decapentaplegic Drosophila melanogaster 14-23 6271176-3 1981 On protonation of the carboxyl group (pK2app = 5.5), the transition temperature increases from 36 to 44 degrees C in the fully hydrated state of dimyristoylphosphatidylserine (from 54 to 62 degrees C for dipalmitoylphosphatidylserine), at ionic strength J = 0.1. dipalmitoylphosphatidylserine 204-233 prokineticin 2 Homo sapiens 38-41 34053427-8 2022 (3) The mRNA and protein expression levels of P-gp, MRP1, and BCRP in the SGC7901/DPP cells were significantly higher than those in the SGC7901 cells. dipalmitoylphosphatidylserine 82-85 ATP binding cassette subfamily B member 1 Homo sapiens 46-50 34053427-8 2022 (3) The mRNA and protein expression levels of P-gp, MRP1, and BCRP in the SGC7901/DPP cells were significantly higher than those in the SGC7901 cells. dipalmitoylphosphatidylserine 82-85 ATP binding cassette subfamily C member 1 Homo sapiens 52-56 34053427-8 2022 (3) The mRNA and protein expression levels of P-gp, MRP1, and BCRP in the SGC7901/DPP cells were significantly higher than those in the SGC7901 cells. dipalmitoylphosphatidylserine 82-85 BCR pseudogene 1 Homo sapiens 62-66 34053427-9 2022 However, after treating with Celastrol, the expression levels of P-gp, MRP1, and BCRP in the SGC7901/DPP cells were significantly reduced (P<0.05). dipalmitoylphosphatidylserine 101-104 ATP binding cassette subfamily B member 1 Homo sapiens 65-69 34053427-9 2022 However, after treating with Celastrol, the expression levels of P-gp, MRP1, and BCRP in the SGC7901/DPP cells were significantly reduced (P<0.05). dipalmitoylphosphatidylserine 101-104 ATP binding cassette subfamily C member 1 Homo sapiens 71-75 34053427-9 2022 However, after treating with Celastrol, the expression levels of P-gp, MRP1, and BCRP in the SGC7901/DPP cells were significantly reduced (P<0.05). dipalmitoylphosphatidylserine 101-104 BCR pseudogene 1 Homo sapiens 81-85 34053427-11 2022 (5) Significantly, the combination of Celastrol and DDP reduced the expression of P-gp, MRP1, and BCRP in the SGC7901/DPP cells. dipalmitoylphosphatidylserine 118-121 ATP binding cassette subfamily B member 1 Homo sapiens 82-86 34053427-11 2022 (5) Significantly, the combination of Celastrol and DDP reduced the expression of P-gp, MRP1, and BCRP in the SGC7901/DPP cells. dipalmitoylphosphatidylserine 118-121 ATP binding cassette subfamily C member 1 Homo sapiens 88-92 34053427-11 2022 (5) Significantly, the combination of Celastrol and DDP reduced the expression of P-gp, MRP1, and BCRP in the SGC7901/DPP cells. dipalmitoylphosphatidylserine 118-121 BCR pseudogene 1 Homo sapiens 98-102 33724554-6 2021 Rnf216 knockout affected the prophase of meiosis I, as no genotypic difference was observed until 12 dpp (days postpartum). dipalmitoylphosphatidylserine 101-104 ring finger protein 216 Mus musculus 0-6 33795773-6 2021 The ACE and DPP-IV inhibitory (IC50) values of P1, P2, and P3 were 0.92 and 0.87, 0.51 and 0.93, 0.78 and 1.16 mg mL-1, respectively. dipalmitoylphosphatidylserine 12-15 L1 cell adhesion molecule Mus musculus 114-118 33719846-13 2021 Moreover, baicalin promoted the inhibitory effect of cisplatin on XRCC1 expression in A549 and A549/DPP cells. dipalmitoylphosphatidylserine 100-103 X-ray repair cross complementing 1 Homo sapiens 66-71 33719846-14 2021 However, the synthetic effects of baicalin and cisplatin on A549/DPP cells were partially inhibited by XRCC1 overexpression and promoted by XRCC1 knockdown. dipalmitoylphosphatidylserine 65-68 X-ray repair cross complementing 1 Homo sapiens 103-108 33719846-14 2021 However, the synthetic effects of baicalin and cisplatin on A549/DPP cells were partially inhibited by XRCC1 overexpression and promoted by XRCC1 knockdown. dipalmitoylphosphatidylserine 65-68 X-ray repair cross complementing 1 Homo sapiens 140-145 33594487-3 2021 PURPOSE: The current study aimed to evaluate the effect of dipeptidyl peptidase IV inhibitors (DPP-IVi), thiazolidinedione (TZD), and sulfonylurea (SU) on osteoporosis in patients with type 2 diabetes. dipalmitoylphosphatidylserine 95-98 dipeptidyl peptidase 4 Homo sapiens 59-82 33298454-6 2020 The boundary between Yki-expressing posterior clones and surrounding wild-type cells acquires properties reminiscent of the anteroposterior compartment boundary; Hedgehog signaling pathway activation results in production of Dpp. dipalmitoylphosphatidylserine 225-228 yorkie Drosophila melanogaster 21-24 33401520-5 2021 The increased DPP levels in laying hens" diet significantly (p < 0.05) increased WBC, Hb and TAC, while heterophil/lymphocyte (H/L ratio) significantly decreased. dipalmitoylphosphatidylserine 14-17 HL Gallus gallus 127-130 33401520-7 2021 In conclusion, the DPP supplementation in the hen diet significantly improved egg production, EW, H/L ratio, ovarian follicles, FSH and LH hormones concentrations. dipalmitoylphosphatidylserine 19-22 HL Gallus gallus 98-101 32407172-12 2020 Also, knockdown of PVT1 enhanced the sensitivity of DPP-resistant GC cells to DPP and inhibited tumor growth in vivo. dipalmitoylphosphatidylserine 52-55 Pvt1 oncogene Homo sapiens 19-23 33318069-1 2020 INTRODUCTION: To report the observations of point-of-care (POC) glycated hemoglobin (HbA1c) testing in people with non-diabetic hyperglycemia (NDH; HbA1c 42-47 mmol/mol (6.0%-6.4%)), applied in community settings, within the English National Health Service Diabetes Prevention Programme (NHS DPP). dipalmitoylphosphatidylserine 292-295 GLIS family zinc finger 3 Homo sapiens 143-146 32407172-12 2020 Also, knockdown of PVT1 enhanced the sensitivity of DPP-resistant GC cells to DPP and inhibited tumor growth in vivo. dipalmitoylphosphatidylserine 78-81 Pvt1 oncogene Homo sapiens 19-23 32379491-13 2020 Conclusions: miR-372 upregulation is associated with DPP resistance of GC cells. dipalmitoylphosphatidylserine 53-56 microRNA 372 Homo sapiens 13-20 32407172-15 2020 Further studies indicated that downregulation of miR-3619-5p transposed PVT1 silencing- or TBL1XR1 silencing-mediated effects on viability, apoptosis, migration, and invasion of DPP-resistant GC cells. dipalmitoylphosphatidylserine 178-181 microRNA 3619 Homo sapiens 49-57 32407172-3 2020 The authors" aim was to investigate the underlying molecular mechanism of PVT1 in cisplatin (DPP) resistance in GC. dipalmitoylphosphatidylserine 93-96 Pvt1 oncogene Homo sapiens 74-78 32407172-10 2020 Results: The levels of PVT1 and TBL1XR1 were significantly upregulated in DPP-resistant GC tissues and cells, while miR-3619-5p was notably declined. dipalmitoylphosphatidylserine 74-77 Pvt1 oncogene Homo sapiens 23-27 32407172-10 2020 Results: The levels of PVT1 and TBL1XR1 were significantly upregulated in DPP-resistant GC tissues and cells, while miR-3619-5p was notably declined. dipalmitoylphosphatidylserine 74-77 TBL1X/Y related 1 Homo sapiens 32-39 32407172-11 2020 Knockdown of PVT1 enhanced DPP sensitivity of DPP-resistant GC cells. dipalmitoylphosphatidylserine 27-30 Pvt1 oncogene Homo sapiens 13-17 32407172-11 2020 Knockdown of PVT1 enhanced DPP sensitivity of DPP-resistant GC cells. dipalmitoylphosphatidylserine 46-49 Pvt1 oncogene Homo sapiens 13-17 32407172-15 2020 Further studies indicated that downregulation of miR-3619-5p transposed PVT1 silencing- or TBL1XR1 silencing-mediated effects on viability, apoptosis, migration, and invasion of DPP-resistant GC cells. dipalmitoylphosphatidylserine 178-181 Pvt1 oncogene Homo sapiens 72-76 32407172-15 2020 Further studies indicated that downregulation of miR-3619-5p transposed PVT1 silencing- or TBL1XR1 silencing-mediated effects on viability, apoptosis, migration, and invasion of DPP-resistant GC cells. dipalmitoylphosphatidylserine 178-181 TBL1X/Y related 1 Homo sapiens 91-98 32407172-16 2020 Conclusions: PVT1 silencing attenuated the DPP resistance in GC by downregulating TBL1XR1 via sponging miR-3619-5p. dipalmitoylphosphatidylserine 43-46 Pvt1 oncogene Homo sapiens 13-17 32407172-16 2020 Conclusions: PVT1 silencing attenuated the DPP resistance in GC by downregulating TBL1XR1 via sponging miR-3619-5p. dipalmitoylphosphatidylserine 43-46 TBL1X/Y related 1 Homo sapiens 82-89 32407172-16 2020 Conclusions: PVT1 silencing attenuated the DPP resistance in GC by downregulating TBL1XR1 via sponging miR-3619-5p. dipalmitoylphosphatidylserine 43-46 microRNA 3619 Homo sapiens 103-111 32840892-4 2020 Here, we show that blocking DPPs using Val-boroPro triggers a lytic form of cell death in primary human CD4 and CD8 T cells, while other prototypical inflammasome stimuli were not active. dipalmitoylphosphatidylserine 28-32 CD4 molecule Homo sapiens 104-107 32463179-1 2020 Because other coronaviruses enter the cells by binding to dipeptidyl-peptidase-4 (DPP-4), it has been speculated that DPP-4 inhibitors (DPP-4is) may exert an activity against severe acute respiratory syndrome coronavirus 2. dipalmitoylphosphatidylserine 82-85 dipeptidyl peptidase 4 Homo sapiens 58-80 32463179-1 2020 Because other coronaviruses enter the cells by binding to dipeptidyl-peptidase-4 (DPP-4), it has been speculated that DPP-4 inhibitors (DPP-4is) may exert an activity against severe acute respiratory syndrome coronavirus 2. dipalmitoylphosphatidylserine 82-85 dipeptidyl peptidase 4 Homo sapiens 118-123 33244267-10 2020 In agreement, PER2-overexpressing SKOV3/DPP cells yielded significantly reduced tumor mass in cisplatin-treated mice compared with control cells. dipalmitoylphosphatidylserine 40-43 period circadian regulator 2 Homo sapiens 14-18 32398684-3 2020 We found that mice with DSS-induced colitis had significantly increased intestinal DPP activity and decreased serum DPP activity, suggesting a probable correlation of DPP4 with experimental colitis. dipalmitoylphosphatidylserine 83-86 dipeptidylpeptidase 4 Mus musculus 167-171 32398684-3 2020 We found that mice with DSS-induced colitis had significantly increased intestinal DPP activity and decreased serum DPP activity, suggesting a probable correlation of DPP4 with experimental colitis. dipalmitoylphosphatidylserine 116-119 dipeptidylpeptidase 4 Mus musculus 167-171 33861731-8 2020 Subgroup analysis of different class of incretinbased drugs showed that therapy with both dipeptidyl peptidase 4 inhibitors (DPP-4Is, SMD = -0.338, p = 0.026) and glucagonlike peptide 1 receptor agonists (GLP-1 RAs, SMD = -0.544, p = 0.003) caused significant reductions in hs-CRP. dipalmitoylphosphatidylserine 125-128 dipeptidyl peptidase 4 Homo sapiens 90-112 32840892-4 2020 Here, we show that blocking DPPs using Val-boroPro triggers a lytic form of cell death in primary human CD4 and CD8 T cells, while other prototypical inflammasome stimuli were not active. dipalmitoylphosphatidylserine 28-32 CD8a molecule Homo sapiens 112-115 33100975-12 2020 For example, we show that Drosophila Nogo signaling is required for dendrite development and that Mummy and Wech also regulate dendrite morphogenesis, potentially via Dpp- and integrin-independent pathways. dipalmitoylphosphatidylserine 167-170 wech Drosophila melanogaster 108-112 32537407-5 2020 A total of 5 x 10-6 m DPP-modified ADSCs (DPP-ADSCs) strongly binds to P-selectin-displaying activated platelets and endothelial cells (ECs) in vitro and to wire-injured rat femoral arteries when administered by intra-arterial injection. dipalmitoylphosphatidylserine 22-25 selectin P Rattus norvegicus 71-81 32876044-8 2020 Finally, we show that downregulation of Wnt signalling and Chk1 expression leads to mitotic re-entry and the concomitant upregulation of Dpp signalling, driving tracheoblast proliferation. dipalmitoylphosphatidylserine 137-140 Wnt oncogene analog 5 Drosophila melanogaster 40-43 32876044-8 2020 Finally, we show that downregulation of Wnt signalling and Chk1 expression leads to mitotic re-entry and the concomitant upregulation of Dpp signalling, driving tracheoblast proliferation. dipalmitoylphosphatidylserine 137-140 grapes Drosophila melanogaster 59-63 32360152-3 2020 METHODS: We performed affinity studies between DPPC and 9:1 DPPC:DPPS-proteoliposomes carrying AnxA5 and/or TNAP and different types of collagen matrix: type I, II, I + III and native collagenous extracellular matrix (ECM) produced from VSMCs with or without differentiation, to simulate ectopic calcification conditions. dipalmitoylphosphatidylserine 65-69 annexin A5 Homo sapiens 95-100 32360152-7 2020 The affinities of DPPC:DPPS-proteoliposomes were high for ECM from VSMCs with or without differentiation, underscoring a synergistic effect between AnxA5 and DPPS. dipalmitoylphosphatidylserine 23-27 annexin A5 Homo sapiens 148-153 32537407-3 2020 Here, conjugated P-selectin binding peptide (PBP) to polyethylene glycol-conjugated phospholipid derivative (DMPE-PEG) linkers (DMPE-PEG-PBP; DPP) are used to facilitate the modification of PBP onto ADSCs cell surfaces via hydrophobic interactions between DMPE-PEG and the phospholipid bilayer. dipalmitoylphosphatidylserine 142-145 phosphatidylethanolamine binding protein 1 Homo sapiens 17-43 32537407-3 2020 Here, conjugated P-selectin binding peptide (PBP) to polyethylene glycol-conjugated phospholipid derivative (DMPE-PEG) linkers (DMPE-PEG-PBP; DPP) are used to facilitate the modification of PBP onto ADSCs cell surfaces via hydrophobic interactions between DMPE-PEG and the phospholipid bilayer. dipalmitoylphosphatidylserine 142-145 phosphatidylethanolamine binding protein 1 Homo sapiens 45-48 32815718-1 2020 The influence of a redox-active ligand on spin-changing events induced by the coordination of exogenous donors is investigated within the cobalt complex [CoII(DPP 2-)], bearing a redox-active DPP2- ligand (DPP = dipyrrin-bis(o,p-di-tert-butylphenolato) with a pentafluorophenyl moiety on the meso-position. dipalmitoylphosphatidylserine 159-162 mitochondrially encoded cytochrome c oxidase II Homo sapiens 154-158 32562757-0 2020 Rab11 is essential for lgl mediated JNK-Dpp signaling in dorsal closure and epithelial morphogenesis in Drosophila. dipalmitoylphosphatidylserine 40-43 Rab11 Drosophila melanogaster 0-5 32562757-0 2020 Rab11 is essential for lgl mediated JNK-Dpp signaling in dorsal closure and epithelial morphogenesis in Drosophila. dipalmitoylphosphatidylserine 40-43 legless Drosophila melanogaster 23-26 32562757-0 2020 Rab11 is essential for lgl mediated JNK-Dpp signaling in dorsal closure and epithelial morphogenesis in Drosophila. dipalmitoylphosphatidylserine 40-43 basket Drosophila melanogaster 36-39 32562757-4 2020 The JNK-Dpp signaling in the dorsolateral epidermis, plays an instrumental role in guiding their fate during this process. dipalmitoylphosphatidylserine 8-11 basket Drosophila melanogaster 4-7 32562757-6 2020 Here we show a probable mechanism via which lgl, a conserved tumour suppressor gene, regulates the JNK-Dpp pathway during dorsal closure and epithelial morphogenesis. dipalmitoylphosphatidylserine 103-106 legless Drosophila melanogaster 44-47 32562757-6 2020 Here we show a probable mechanism via which lgl, a conserved tumour suppressor gene, regulates the JNK-Dpp pathway during dorsal closure and epithelial morphogenesis. dipalmitoylphosphatidylserine 103-106 basket Drosophila melanogaster 99-102 32562757-9 2020 Our experiment suggests Rab11 to be interacting with lgl as they seem to synergize in order to regulate the core JNK-Dpp signaling pathway during dorsal closure and also during adult thorax closure process. dipalmitoylphosphatidylserine 117-120 Rab11 Drosophila melanogaster 24-29 32562757-9 2020 Our experiment suggests Rab11 to be interacting with lgl as they seem to synergize in order to regulate the core JNK-Dpp signaling pathway during dorsal closure and also during adult thorax closure process. dipalmitoylphosphatidylserine 117-120 legless Drosophila melanogaster 53-56 32562757-9 2020 Our experiment suggests Rab11 to be interacting with lgl as they seem to synergize in order to regulate the core JNK-Dpp signaling pathway during dorsal closure and also during adult thorax closure process. dipalmitoylphosphatidylserine 117-120 basket Drosophila melanogaster 113-116 32216935-7 2020 There were greater serum IL-1beta and TNF-alpha concentrations on 28 dpp in cows with SCE than NC group. dipalmitoylphosphatidylserine 69-72 interleukin 1 alpha Bos taurus 25-33 32216935-7 2020 There were greater serum IL-1beta and TNF-alpha concentrations on 28 dpp in cows with SCE than NC group. dipalmitoylphosphatidylserine 69-72 tumor necrosis factor Bos taurus 38-47 31521887-5 2019 Due to its multivalent topology, DPP exhibited stronger membrane activity yet lower cytotoxicity than its linear analogue (LPP), thus enabling efficient PKM2 silencing in MCF-7 cells in vitro (~75%) and in vivo (~70%). dipalmitoylphosphatidylserine 33-36 pyruvate kinase M1/2 Homo sapiens 153-157 32512657-7 2020 In addition, kaempferol increased the sensitivity of A2780 cells to DPP (IC50 from 6.867 +- 0.99 to 3.73 +- 0.59 mumol/l) by decreasing the protein levels of p-Akt (0.31 +- 0.09 vs 0.12 +- 0.005). dipalmitoylphosphatidylserine 68-71 AKT serine/threonine kinase 1 Homo sapiens 160-163 31981320-4 2020 We identified and biologically validated miR-92a as a transcriptional regulator of mothers against DPP homologues 7 (SMAD7), a known inhibitor of alpha-smooth muscle actin (alpha-SMA), established marker of myofibroblast activation. dipalmitoylphosphatidylserine 99-102 SMAD family member 7 Mus musculus 117-122 31981320-4 2020 We identified and biologically validated miR-92a as a transcriptional regulator of mothers against DPP homologues 7 (SMAD7), a known inhibitor of alpha-smooth muscle actin (alpha-SMA), established marker of myofibroblast activation. dipalmitoylphosphatidylserine 99-102 actin alpha 2, smooth muscle, aorta Mus musculus 173-182 31326454-4 2019 RESULT: At baseline, patients initiated on SGLT-2i are younger (about 6 years) and more heavy (about 7.5 kg), have higher A1C level (0.5% more), a longer diabetes duration and more CV events (20% more) than patients initiated on DPP-4i. dipalmitoylphosphatidylserine 229-232 solute carrier family 5 member 2 Homo sapiens 43-49 31431452-1 2019 OBJECTIVE: Dipeptidyl peptidase-4 inhibitors (DPP-4i) are useful incretin-based antidiabetes drugs. dipalmitoylphosphatidylserine 46-49 dipeptidyl peptidase 4 Homo sapiens 11-33 31251896-6 2019 Molecular dissection of the dpp regulatory region and in vivo protein interaction experiments suggest that Abd-BR, Exd, Hth and DsxF coordinately regulate a short dpp enhancer to repress dpp expression and restrict female A9 size. dipalmitoylphosphatidylserine 28-31 extradenticle Drosophila melanogaster 115-118 31251896-6 2019 Molecular dissection of the dpp regulatory region and in vivo protein interaction experiments suggest that Abd-BR, Exd, Hth and DsxF coordinately regulate a short dpp enhancer to repress dpp expression and restrict female A9 size. dipalmitoylphosphatidylserine 28-31 homothorax Drosophila melanogaster 120-123 31251896-6 2019 Molecular dissection of the dpp regulatory region and in vivo protein interaction experiments suggest that Abd-BR, Exd, Hth and DsxF coordinately regulate a short dpp enhancer to repress dpp expression and restrict female A9 size. dipalmitoylphosphatidylserine 28-31 doublesex Drosophila melanogaster 128-132 31251896-6 2019 Molecular dissection of the dpp regulatory region and in vivo protein interaction experiments suggest that Abd-BR, Exd, Hth and DsxF coordinately regulate a short dpp enhancer to repress dpp expression and restrict female A9 size. dipalmitoylphosphatidylserine 163-166 extradenticle Drosophila melanogaster 115-118 31251896-6 2019 Molecular dissection of the dpp regulatory region and in vivo protein interaction experiments suggest that Abd-BR, Exd, Hth and DsxF coordinately regulate a short dpp enhancer to repress dpp expression and restrict female A9 size. dipalmitoylphosphatidylserine 163-166 homothorax Drosophila melanogaster 120-123 31251896-6 2019 Molecular dissection of the dpp regulatory region and in vivo protein interaction experiments suggest that Abd-BR, Exd, Hth and DsxF coordinately regulate a short dpp enhancer to repress dpp expression and restrict female A9 size. dipalmitoylphosphatidylserine 163-166 doublesex Drosophila melanogaster 128-132 31251896-6 2019 Molecular dissection of the dpp regulatory region and in vivo protein interaction experiments suggest that Abd-BR, Exd, Hth and DsxF coordinately regulate a short dpp enhancer to repress dpp expression and restrict female A9 size. dipalmitoylphosphatidylserine 163-166 extradenticle Drosophila melanogaster 115-118 31251896-6 2019 Molecular dissection of the dpp regulatory region and in vivo protein interaction experiments suggest that Abd-BR, Exd, Hth and DsxF coordinately regulate a short dpp enhancer to repress dpp expression and restrict female A9 size. dipalmitoylphosphatidylserine 163-166 homothorax Drosophila melanogaster 120-123 31251896-6 2019 Molecular dissection of the dpp regulatory region and in vivo protein interaction experiments suggest that Abd-BR, Exd, Hth and DsxF coordinately regulate a short dpp enhancer to repress dpp expression and restrict female A9 size. dipalmitoylphosphatidylserine 163-166 doublesex Drosophila melanogaster 128-132 31110028-0 2019 Sequence environment of BMP-dependent activating elements controls transcriptional responses to Dpp signaling in Drosophila. dipalmitoylphosphatidylserine 96-99 decapentaplegic Drosophila melanogaster 24-27 30669963-5 2019 Dpp signaling in ML-DmD17-c3 cells is primarily mediated by the receptors Put and Tkv, with additional contributions from Wit and Sax. dipalmitoylphosphatidylserine 0-3 thickveins Drosophila melanogaster 82-85 30706537-7 2019 The obtained results indicated that CGTHW-3 cells treated with silenced SLPI or overexpressed miR-539 suppressed the cell proliferation, migration, invasion abilities, and resistance to apoptosis of PTC cells, corresponding to increased expression of Bcl-2-associated X protein, TGF-beta1, Sekelsky mothers against dpp 4, and epithelial cadherin, and decreased B cell lymphoma 2, Vimentin, and N-cadherin. dipalmitoylphosphatidylserine 315-318 secretory leukocyte peptidase inhibitor Homo sapiens 72-76 30706537-7 2019 The obtained results indicated that CGTHW-3 cells treated with silenced SLPI or overexpressed miR-539 suppressed the cell proliferation, migration, invasion abilities, and resistance to apoptosis of PTC cells, corresponding to increased expression of Bcl-2-associated X protein, TGF-beta1, Sekelsky mothers against dpp 4, and epithelial cadherin, and decreased B cell lymphoma 2, Vimentin, and N-cadherin. dipalmitoylphosphatidylserine 315-318 microRNA 539 Homo sapiens 94-101 30665104-7 2019 The results of qPCR indicated that exposure to 13-52 mg L-1 Cd affected the expression of reproduction-related genes, including downregulation of enok and upregulation of dally and dpp. dipalmitoylphosphatidylserine 181-184 l(1)L1 Drosophila melanogaster 56-59 30530814-7 2019 In recombinant DPP family such as DPP-4, DPP-2, DPP-8, DPP-9, and fibroblast activation protein-alpha, more hydrolytic metabolites were found. dipalmitoylphosphatidylserine 15-18 dipeptidylpeptidase 4 Rattus norvegicus 34-39 30530814-7 2019 In recombinant DPP family such as DPP-4, DPP-2, DPP-8, DPP-9, and fibroblast activation protein-alpha, more hydrolytic metabolites were found. dipalmitoylphosphatidylserine 15-18 dipeptidylpeptidase 7 Rattus norvegicus 41-46 30530814-7 2019 In recombinant DPP family such as DPP-4, DPP-2, DPP-8, DPP-9, and fibroblast activation protein-alpha, more hydrolytic metabolites were found. dipalmitoylphosphatidylserine 15-18 dipeptidylpeptidase 8 Rattus norvegicus 48-53 30530814-7 2019 In recombinant DPP family such as DPP-4, DPP-2, DPP-8, DPP-9, and fibroblast activation protein-alpha, more hydrolytic metabolites were found. dipalmitoylphosphatidylserine 15-18 dipeptidyl peptidase 9 Rattus norvegicus 55-60 30530814-7 2019 In recombinant DPP family such as DPP-4, DPP-2, DPP-8, DPP-9, and fibroblast activation protein-alpha, more hydrolytic metabolites were found. dipalmitoylphosphatidylserine 15-18 fibroblast activation protein, alpha Rattus norvegicus 66-101 30372881-7 2018 Conversely, CASC2 knockdown weakened the response of BGC823 and SGC7901 to DPP. dipalmitoylphosphatidylserine 75-78 cancer susceptibility 2 Homo sapiens 12-17 30444043-10 2019 Conversely, miR-381 inhibition lowered the response of MCF-7 and MDA-MB-231 to DPP. dipalmitoylphosphatidylserine 79-82 microRNA 381 Homo sapiens 12-19 30171910-8 2018 STAT3 inhibitors, DPP (5 muM) and S3I-201 (50 muM), reduced expression of BDNF, GDNF, and GFAP. dipalmitoylphosphatidylserine 18-21 brain derived neurotrophic factor Mus musculus 74-78 30171910-8 2018 STAT3 inhibitors, DPP (5 muM) and S3I-201 (50 muM), reduced expression of BDNF, GDNF, and GFAP. dipalmitoylphosphatidylserine 18-21 glial cell line derived neurotrophic factor Mus musculus 80-84 30122445-4 2018 In parallel, Tkv promotes Hh signaling, which promotes escort cell cellular protrusions and upregulates expression of the Drosophila BMP homolog, Dpp, forming a positive feedback loop that enhances Tkv signaling and strengthens the niche boundary. dipalmitoylphosphatidylserine 146-149 decapentaplegic Drosophila melanogaster 133-136 30402851-14 2018 However, the transfection of miR-107 mimic and/or si-mTOR remarkably suppressed expressions of mTOR, p-mTOR and survivin in U251/DPP cells, weakened cell proliferation and enhanced apoptosis. dipalmitoylphosphatidylserine 129-132 mechanistic target of rapamycin kinase Homo sapiens 95-99 30402851-16 2018 Over-expression of miR-107 decreased DPP resistance of glioma cells via inhibition of mTOR, which provides academic basis for the future anti-glioma therapy. dipalmitoylphosphatidylserine 37-40 microRNA 107 Homo sapiens 19-26 30402851-16 2018 Over-expression of miR-107 decreased DPP resistance of glioma cells via inhibition of mTOR, which provides academic basis for the future anti-glioma therapy. dipalmitoylphosphatidylserine 37-40 mechanistic target of rapamycin kinase Homo sapiens 86-90 30122445-4 2018 In parallel, Tkv promotes Hh signaling, which promotes escort cell cellular protrusions and upregulates expression of the Drosophila BMP homolog, Dpp, forming a positive feedback loop that enhances Tkv signaling and strengthens the niche boundary. dipalmitoylphosphatidylserine 146-149 thickveins Drosophila melanogaster 13-16 30402851-14 2018 However, the transfection of miR-107 mimic and/or si-mTOR remarkably suppressed expressions of mTOR, p-mTOR and survivin in U251/DPP cells, weakened cell proliferation and enhanced apoptosis. dipalmitoylphosphatidylserine 129-132 microRNA 107 Homo sapiens 29-36 30402851-14 2018 However, the transfection of miR-107 mimic and/or si-mTOR remarkably suppressed expressions of mTOR, p-mTOR and survivin in U251/DPP cells, weakened cell proliferation and enhanced apoptosis. dipalmitoylphosphatidylserine 129-132 mechanistic target of rapamycin kinase Homo sapiens 53-57 30402851-14 2018 However, the transfection of miR-107 mimic and/or si-mTOR remarkably suppressed expressions of mTOR, p-mTOR and survivin in U251/DPP cells, weakened cell proliferation and enhanced apoptosis. dipalmitoylphosphatidylserine 129-132 mechanistic target of rapamycin kinase Homo sapiens 95-99 29404895-0 2018 Molecular AFM imaging of Hsp70-1A association with dipalmitoyl phosphatidylserine reveals membrane blebbing in the presence of cholesterol. dipalmitoylphosphatidylserine 51-81 heat shock protein family A (Hsp70) member 1A Homo sapiens 25-33 30142157-2 2018 Initial EGFR activation occurs in the center of leg discs by expression of the EGFR ligand Vn and the EGFR ligand-processing protease Rho, each through single enhancers, vnE and rhoE, that integrate inputs from Wg, Dpp, Dll and Sp1. dipalmitoylphosphatidylserine 215-218 Epidermal growth factor receptor Drosophila melanogaster 8-12 30142157-2 2018 Initial EGFR activation occurs in the center of leg discs by expression of the EGFR ligand Vn and the EGFR ligand-processing protease Rho, each through single enhancers, vnE and rhoE, that integrate inputs from Wg, Dpp, Dll and Sp1. dipalmitoylphosphatidylserine 215-218 runt Drosophila melanogaster 48-51 30142157-2 2018 Initial EGFR activation occurs in the center of leg discs by expression of the EGFR ligand Vn and the EGFR ligand-processing protease Rho, each through single enhancers, vnE and rhoE, that integrate inputs from Wg, Dpp, Dll and Sp1. dipalmitoylphosphatidylserine 215-218 Epidermal growth factor receptor Drosophila melanogaster 79-83 30142157-2 2018 Initial EGFR activation occurs in the center of leg discs by expression of the EGFR ligand Vn and the EGFR ligand-processing protease Rho, each through single enhancers, vnE and rhoE, that integrate inputs from Wg, Dpp, Dll and Sp1. dipalmitoylphosphatidylserine 215-218 Epidermal growth factor receptor Drosophila melanogaster 79-83 29576501-2 2018 METHODS: The SHED were isolated from fresh dental pulp and were induced to differentiate to neurons and dopamine neurons by inhibiting similar mothers against dpp (SMAD) signaling with Noggin and increase conversion of dopamine neurons from SHED with CHIR99021, Sonic Hedgehog (SHH) and FGF8 in vitro. dipalmitoylphosphatidylserine 159-162 noggin Rattus norvegicus 185-191 29654165-9 2018 Furthermore, overexpressed NEAT1 reduced the sensitivity of cisplatin (DDP) and inhibited DDP-induced apoptosis and cell cycle arrest via miR-34c The results in vivo also confirmed that knockdown of NEAT1 sensitized the OS cells to DPP-induced tumor regression, delayed the tumor growth with reduced levels of Ki-67, BCL-2, and cyclin D1 signals, suggesting that NEAT1 is an oncogene and chemotherapy resistant factor in OS. dipalmitoylphosphatidylserine 232-235 nuclear paraspeckle assembly transcript 1 Homo sapiens 27-32 29654165-9 2018 Furthermore, overexpressed NEAT1 reduced the sensitivity of cisplatin (DDP) and inhibited DDP-induced apoptosis and cell cycle arrest via miR-34c The results in vivo also confirmed that knockdown of NEAT1 sensitized the OS cells to DPP-induced tumor regression, delayed the tumor growth with reduced levels of Ki-67, BCL-2, and cyclin D1 signals, suggesting that NEAT1 is an oncogene and chemotherapy resistant factor in OS. dipalmitoylphosphatidylserine 232-235 microRNA 34c Homo sapiens 138-145 29654165-9 2018 Furthermore, overexpressed NEAT1 reduced the sensitivity of cisplatin (DDP) and inhibited DDP-induced apoptosis and cell cycle arrest via miR-34c The results in vivo also confirmed that knockdown of NEAT1 sensitized the OS cells to DPP-induced tumor regression, delayed the tumor growth with reduced levels of Ki-67, BCL-2, and cyclin D1 signals, suggesting that NEAT1 is an oncogene and chemotherapy resistant factor in OS. dipalmitoylphosphatidylserine 232-235 nuclear paraspeckle assembly transcript 1 Homo sapiens 199-204 29654165-9 2018 Furthermore, overexpressed NEAT1 reduced the sensitivity of cisplatin (DDP) and inhibited DDP-induced apoptosis and cell cycle arrest via miR-34c The results in vivo also confirmed that knockdown of NEAT1 sensitized the OS cells to DPP-induced tumor regression, delayed the tumor growth with reduced levels of Ki-67, BCL-2, and cyclin D1 signals, suggesting that NEAT1 is an oncogene and chemotherapy resistant factor in OS. dipalmitoylphosphatidylserine 232-235 nuclear paraspeckle assembly transcript 1 Homo sapiens 199-204 29740006-5 2018 Furthermore, using genetic and cell biological approaches, we demonstrate that ectopic upregulation of dpp caused by loss of Egg in the germarium can trigger apoptotic cell death through activation of two pro-apoptotic genes, reaper and head involution defective. dipalmitoylphosphatidylserine 103-106 reaper Drosophila melanogaster 226-232 29125198-3 2018 In reaction with allyl bromide, complex 2 gave metal- and ligand-centered addition products (dpp-bian)Ga(eta1 -All)Br (6) and (dpp-bian-All)(Br)Ga-Ga(Br)(dpp-bian-All) (7). dipalmitoylphosphatidylserine 93-96 secreted phosphoprotein 1 Homo sapiens 105-109 29338181-4 2018 By utilizing a siloxane-terminated alkyl chain and a branched alkyl chain as solubilizing groups, the matrix polymer DPP-C5 presents a melting temperature of 115 C. The resulting c-SPB containing as low as 5% of the fully conjugated polymer could be melt-processed at 130 C. The obtained OFET devices exhibit hole mobility approaching 1.0 cm2/(V s), threshold voltages below 5 V, and ION/IOFF around 105. dipalmitoylphosphatidylserine 117-120 granzyme B Homo sapiens 180-185 29361569-5 2018 Anterior escort cells function as an integral niche component by promoting DE-cadherin anchorage and by transiently expressing the Dpp ligand to promote full-strength BMP signaling in germline stem cells. dipalmitoylphosphatidylserine 131-134 decapentaplegic Drosophila melanogaster 167-170 29382749-2 2018 While the DPP family member DPP4 is extensively characterized in molecular terms as a validated therapeutic target of type II diabetes, experimental 3D structures and ligand-/substrate-binding modes of DPP8 and DPP9 have not been reported. dipalmitoylphosphatidylserine 10-13 dipeptidyl peptidase 4 Homo sapiens 28-32 29382749-2 2018 While the DPP family member DPP4 is extensively characterized in molecular terms as a validated therapeutic target of type II diabetes, experimental 3D structures and ligand-/substrate-binding modes of DPP8 and DPP9 have not been reported. dipalmitoylphosphatidylserine 10-13 dipeptidyl peptidase 9 Homo sapiens 211-215 30481785-6 2018 We found that ZEB1 was increased in cisplatin-resistant SKOV3/DPP cells. dipalmitoylphosphatidylserine 62-65 zinc finger E-box binding homeobox 1 Homo sapiens 14-18 30481785-9 2018 SLC3A2 was decreased in cisplatin-resistant SKOV3/DPP cells. dipalmitoylphosphatidylserine 50-53 solute carrier family 3 member 2 Homo sapiens 0-6 28826503-7 2017 Loss of Pngl results in a severe decrease in the level of Dpp homodimers and abolishes BMP autoregulation in the visceral mesoderm mediated by Dpp and Tkv homodimers. dipalmitoylphosphatidylserine 58-61 PNGase-like Drosophila melanogaster 8-12 29108021-5 2017 Furthermore, through functional genetic screening, bioinformatic analyses and yeast one-hybrid screening, we determined that the transcription factors Scalloped (Sd), Mothers against dpp (Mad), and D-Fos are principal regulators of upd3 expression. dipalmitoylphosphatidylserine 183-186 unpaired 3 Drosophila melanogaster 232-236 29030610-5 2017 We demonstrate that Ance expression in eye and wing discs depends on Dpp signaling. dipalmitoylphosphatidylserine 69-72 Angiotensin converting enzyme Drosophila melanogaster 20-24 29030610-10 2017 Ance null mutants are morphologically normal but show genetic interaction with dpp mutants. dipalmitoylphosphatidylserine 79-82 Angiotensin converting enzyme Drosophila melanogaster 0-4 28779212-13 2017 A significant increase of both GLP-1 and EPAC-1 was found after treatment with DPP-IVi (p < 0.05). dipalmitoylphosphatidylserine 79-82 glucagon like peptide 1 receptor Homo sapiens 31-36 28779212-13 2017 A significant increase of both GLP-1 and EPAC-1 was found after treatment with DPP-IVi (p < 0.05). dipalmitoylphosphatidylserine 79-82 Rap guanine nucleotide exchange factor 3 Homo sapiens 41-47 28928281-6 2017 Our data demonstrate that Engrailed, a homeodomain-containing transcription factor that serves as a cap cell marker, binds to this region and regulates dpp expression in cap cells. dipalmitoylphosphatidylserine 152-155 engrailed Drosophila melanogaster 26-35 28928281-7 2017 Further data suggest that En forms a complex with Nejire (Nej), the Drosophila ortholog of histone acetyltransferase CBP/p300, and directs Nej to this cis-regulatory region where Nej functions as the co-activator for dpp expression. dipalmitoylphosphatidylserine 217-220 nejire Drosophila melanogaster 117-125 28829945-0 2017 CycD/Cdk4 and Discontinuities in Dpp Signaling Activate TORC1 in the Drosophila Wing Disc. dipalmitoylphosphatidylserine 33-36 CREB-regulated transcription coactivator Drosophila melanogaster 56-61 28829945-0 2017 CycD/Cdk4 and Discontinuities in Dpp Signaling Activate TORC1 in the Drosophila Wing Disc. dipalmitoylphosphatidylserine 33-36 disconnected Drosophila melanogaster 14-18 28829945-8 2017 We find that TORC1 is also activated independently of CycD/Cdk4 when cells with different levels of Dpp signaling or Brinker protein are juxtaposed. dipalmitoylphosphatidylserine 100-103 CREB-regulated transcription coactivator Drosophila melanogaster 13-18 28642242-5 2017 The Hox gene Ultrabithorax (Ubx), expressed in the developing T3, selects haltere identity by, among other processes, modulating the production and signaling efficiency of Dpp, a BMP2-like molecule that acts as a major regulator of size and pattern. dipalmitoylphosphatidylserine 172-175 tinman Drosophila melanogaster 4-7 28642242-5 2017 The Hox gene Ultrabithorax (Ubx), expressed in the developing T3, selects haltere identity by, among other processes, modulating the production and signaling efficiency of Dpp, a BMP2-like molecule that acts as a major regulator of size and pattern. dipalmitoylphosphatidylserine 172-175 Ultrabithorax Drosophila melanogaster 13-26 28642242-5 2017 The Hox gene Ultrabithorax (Ubx), expressed in the developing T3, selects haltere identity by, among other processes, modulating the production and signaling efficiency of Dpp, a BMP2-like molecule that acts as a major regulator of size and pattern. dipalmitoylphosphatidylserine 172-175 Ultrabithorax Drosophila melanogaster 28-31 28642242-8 2017 We find that in both organs, Dpp defines the expression domain of optix through repression, and that the specific position of this domain in wing and haltere seems to reflect the differential signaling profile among these organs. dipalmitoylphosphatidylserine 29-32 optix Drosophila melanogaster 66-71 28826503-7 2017 Loss of Pngl results in a severe decrease in the level of Dpp homodimers and abolishes BMP autoregulation in the visceral mesoderm mediated by Dpp and Tkv homodimers. dipalmitoylphosphatidylserine 143-146 PNGase-like Drosophila melanogaster 8-12 28390801-6 2017 As demonstrated previously for inx2, inx3 regulates disc cell proliferation and interacts genetically with the Dpp pathway, being required for the proper activation of the Dpp pathway transducer Mad at the furrow and the expression of Dpp receptor Punt in the eye disc. dipalmitoylphosphatidylserine 111-114 Innexin 2 Drosophila melanogaster 31-35 28390801-6 2017 As demonstrated previously for inx2, inx3 regulates disc cell proliferation and interacts genetically with the Dpp pathway, being required for the proper activation of the Dpp pathway transducer Mad at the furrow and the expression of Dpp receptor Punt in the eye disc. dipalmitoylphosphatidylserine 111-114 Innexin 3 Drosophila melanogaster 37-41 28390801-6 2017 As demonstrated previously for inx2, inx3 regulates disc cell proliferation and interacts genetically with the Dpp pathway, being required for the proper activation of the Dpp pathway transducer Mad at the furrow and the expression of Dpp receptor Punt in the eye disc. dipalmitoylphosphatidylserine 111-114 punt Drosophila melanogaster 235-247 28390801-6 2017 As demonstrated previously for inx2, inx3 regulates disc cell proliferation and interacts genetically with the Dpp pathway, being required for the proper activation of the Dpp pathway transducer Mad at the furrow and the expression of Dpp receptor Punt in the eye disc. dipalmitoylphosphatidylserine 172-175 Innexin 2 Drosophila melanogaster 31-35 28390801-6 2017 As demonstrated previously for inx2, inx3 regulates disc cell proliferation and interacts genetically with the Dpp pathway, being required for the proper activation of the Dpp pathway transducer Mad at the furrow and the expression of Dpp receptor Punt in the eye disc. dipalmitoylphosphatidylserine 172-175 Innexin 3 Drosophila melanogaster 37-41 28315838-8 2017 Further, we discovered that the JNK signaling pathway operated between Rab5 and Dpp, because simultaneously inhibiting the JNK pathway and Rab5 in cyst cells prevented both dpp transcription and germline tumor growth. dipalmitoylphosphatidylserine 173-176 basket Drosophila melanogaster 32-35 28315838-8 2017 Further, we discovered that the JNK signaling pathway operated between Rab5 and Dpp, because simultaneously inhibiting the JNK pathway and Rab5 in cyst cells prevented both dpp transcription and germline tumor growth. dipalmitoylphosphatidylserine 173-176 decapentaplegic Drosophila melanogaster 80-83 28315838-8 2017 Further, we discovered that the JNK signaling pathway operated between Rab5 and Dpp, because simultaneously inhibiting the JNK pathway and Rab5 in cyst cells prevented both dpp transcription and germline tumor growth. dipalmitoylphosphatidylserine 173-176 basket Drosophila melanogaster 123-126 28315838-8 2017 Further, we discovered that the JNK signaling pathway operated between Rab5 and Dpp, because simultaneously inhibiting the JNK pathway and Rab5 in cyst cells prevented both dpp transcription and germline tumor growth. dipalmitoylphosphatidylserine 173-176 Rab5 Drosophila melanogaster 139-143 28327288-6 2017 We show that Atro regulates Dpp and Notch signaling in larval imaginal discs, at least partially via regulation of thickveins and fringe. dipalmitoylphosphatidylserine 28-31 Grunge Drosophila melanogaster 13-17 28330877-0 2017 K+ Channel Modulatory Subunits KChIP and DPP Participate in Kv4-Mediated Mechanical Pain Control. dipalmitoylphosphatidylserine 41-44 potassium voltage-gated channel subfamily A member 4 Rattus norvegicus 60-63 27878245-5 2017 MTT assay was utilized to evaluate effects of baicalin and DDP on the proliferation of A549 and A549/DPP (DPP-resistant) human lung cancer cells. dipalmitoylphosphatidylserine 101-104 translocase of inner mitochondrial membrane 8A Homo sapiens 59-62 27174745-6 2017 In testicular sections on 0day postpartum (dpp), gonocytes, Sertoli cells and foetal Leydig cells showed OXA and OX1R-immunopositive signals. dipalmitoylphosphatidylserine 43-46 hypocretin Mus musculus 105-108 27174745-6 2017 In testicular sections on 0day postpartum (dpp), gonocytes, Sertoli cells and foetal Leydig cells showed OXA and OX1R-immunopositive signals. dipalmitoylphosphatidylserine 43-46 hypocretin (orexin) receptor 1 Mus musculus 113-117 27878245-5 2017 MTT assay was utilized to evaluate effects of baicalin and DDP on the proliferation of A549 and A549/DPP (DPP-resistant) human lung cancer cells. dipalmitoylphosphatidylserine 106-109 translocase of inner mitochondrial membrane 8A Homo sapiens 59-62 27878245-11 2017 When baicalin (8 microg/ml) and DDP (4 microg/ml) were combined, the inhibitory rate of tumor cell invasion increased markedly compared to DPP or baicalin alone groups in both A549 and A549/DDP cells. dipalmitoylphosphatidylserine 139-142 translocase of inner mitochondrial membrane 8A Homo sapiens 32-35 27550943-9 2016 DPP-23 activated p53 and its related cell death pathways via a robust accumulation of cellular ROS that involved inhibition of nuclear factor erythroid 2-related factor 2 antioxidant defense mechanisms. dipalmitoylphosphatidylserine 0-3 transformation related protein 53, pseudogene Mus musculus 17-20 27686452-5 2016 In this study, we first constructed a cisplatin-resistant A549 cell line (A549/DPP) accompanied with a decreased expression of miR-451 and an increased expression of Mcl-1in the drug resistant cells compared with the parental cells. dipalmitoylphosphatidylserine 79-82 microRNA 451a Homo sapiens 127-134 27686452-5 2016 In this study, we first constructed a cisplatin-resistant A549 cell line (A549/DPP) accompanied with a decreased expression of miR-451 and an increased expression of Mcl-1in the drug resistant cells compared with the parental cells. dipalmitoylphosphatidylserine 79-82 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 166-171 27686452-6 2016 Exogenous expression of miR-451 level in A549/DPP was found to sensitize their reaction to the treatment of cisplatin, which coincides with reduced expression of Mcl-1. dipalmitoylphosphatidylserine 46-49 microRNA 451a Homo sapiens 24-31 27686452-6 2016 Exogenous expression of miR-451 level in A549/DPP was found to sensitize their reaction to the treatment of cisplatin, which coincides with reduced expression of Mcl-1. dipalmitoylphosphatidylserine 46-49 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 162-167 27686452-7 2016 Interestingly, Mcl-1 knockdown in A549/DPP cells increased the chemosensitivity to DPP, suggesting the dependence of Mcl-1 regulation in miR-451 activity. dipalmitoylphosphatidylserine 39-42 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 15-20 27686452-7 2016 Interestingly, Mcl-1 knockdown in A549/DPP cells increased the chemosensitivity to DPP, suggesting the dependence of Mcl-1 regulation in miR-451 activity. dipalmitoylphosphatidylserine 39-42 microRNA 451a Homo sapiens 137-144 27686452-7 2016 Interestingly, Mcl-1 knockdown in A549/DPP cells increased the chemosensitivity to DPP, suggesting the dependence of Mcl-1 regulation in miR-451 activity. dipalmitoylphosphatidylserine 83-86 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 15-20 27686452-7 2016 Interestingly, Mcl-1 knockdown in A549/DPP cells increased the chemosensitivity to DPP, suggesting the dependence of Mcl-1 regulation in miR-451 activity. dipalmitoylphosphatidylserine 83-86 microRNA 451a Homo sapiens 137-144 27686452-9 2016 Thus, these findings provided that in lung cancer cells, tumor suppressor miR-451 enhanced DPP sensitivity via regulation of Mcl-1 expression, which could be served as a novel therapeutic target for the treatment of chemotherapy resistant in lung cancer. dipalmitoylphosphatidylserine 91-94 microRNA 451a Homo sapiens 74-81 27686452-9 2016 Thus, these findings provided that in lung cancer cells, tumor suppressor miR-451 enhanced DPP sensitivity via regulation of Mcl-1 expression, which could be served as a novel therapeutic target for the treatment of chemotherapy resistant in lung cancer. dipalmitoylphosphatidylserine 91-94 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 125-130 27550943-9 2016 DPP-23 activated p53 and its related cell death pathways via a robust accumulation of cellular ROS that involved inhibition of nuclear factor erythroid 2-related factor 2 antioxidant defense mechanisms. dipalmitoylphosphatidylserine 0-3 nuclear factor, erythroid derived 2, like 2 Mus musculus 127-170 27338051-11 2016 In A549/DDP cells, GAS5 showed the similar effect as 3-MA in reducing DPP IC50 and promoting DDP-induced apoptosis and also presented synergic effect with 3-MA. dipalmitoylphosphatidylserine 70-73 growth arrest specific 5 Homo sapiens 19-23 27357419-8 2016 Additionally, miR-20a was upregulated in GC plasma and tissues from patients with cisplatin (DDP) resistance, and in the DPP-resistant gastric cancer cell line (SGC7901/DDP). dipalmitoylphosphatidylserine 121-124 microRNA 20a Homo sapiens 14-21 26845195-1 2016 In summary, the patterning of the presumptive leg depends on gradients of Dpp and Wg morphogens, which lead to the establishment of the proximo-distal axis marked by the expression of Hth, Dac and Dll in broad domains along the leg. dipalmitoylphosphatidylserine 74-77 arylacetamide deacetylase Homo sapiens 189-192 27269283-2 2016 Here we investigate the function of Pentagone (Pent), a secreted protein that acts in a regulatory feedback during establishment and maintenance of BMP/Dpp morphogen signalling during Drosophila wing development. dipalmitoylphosphatidylserine 152-155 magu Drosophila melanogaster 36-45 27269283-2 2016 Here we investigate the function of Pentagone (Pent), a secreted protein that acts in a regulatory feedback during establishment and maintenance of BMP/Dpp morphogen signalling during Drosophila wing development. dipalmitoylphosphatidylserine 152-155 magu Drosophila melanogaster 36-40 27269283-3 2016 We show that Pent internalises the Dpp co-receptors, the glypicans Dally and Dally-like protein (Dlp), and propose that this internalisation is important in the establishment of a long range Dpp gradient. dipalmitoylphosphatidylserine 35-38 magu Drosophila melanogaster 13-17 27269283-3 2016 We show that Pent internalises the Dpp co-receptors, the glypicans Dally and Dally-like protein (Dlp), and propose that this internalisation is important in the establishment of a long range Dpp gradient. dipalmitoylphosphatidylserine 35-38 dally-like Drosophila melanogaster 97-100 29797935-4 2016 Conclusion:We were the first to found that CXCR4 was related to chemoresistance of CNE2/DPP to cisplatin. dipalmitoylphosphatidylserine 88-91 C-X-C motif chemokine receptor 4 Homo sapiens 43-48 29797935-5 2016 Meanwhile, we confirmed that CXCR4 affected the expression of bcl-2 through regulating the expression of let-7a to modulate the chemoresistance of CNE2/DPP to cisplatin. dipalmitoylphosphatidylserine 152-155 C-X-C motif chemokine receptor 4 Homo sapiens 29-34 29797935-5 2016 Meanwhile, we confirmed that CXCR4 affected the expression of bcl-2 through regulating the expression of let-7a to modulate the chemoresistance of CNE2/DPP to cisplatin. dipalmitoylphosphatidylserine 152-155 BCL2 apoptosis regulator Homo sapiens 62-67 27049928-8 2016 The 2 subpopulations cells were both sensitive to DDP, among which, the effect of DPP on proliferation ability and tumor-forming ability of CD133-positive cells was obviously greater than that of CD133-negative cells. dipalmitoylphosphatidylserine 82-85 prominin 1 Homo sapiens 140-145 26930324-1 2016 The success of dipeptidyl peptidase 4 (DPP4) inhibition as a type 2 diabetes therapy has encouraged deeper examination of the post-proline DPP enzymes. dipalmitoylphosphatidylserine 39-42 dipeptidylpeptidase 4 Mus musculus 15-37 26599604-4 2015 The position of the zone that is predicted based on quantitative data for the Dpp morphogen corresponds to where the Dpp-dependent gene expression boundaries of spalt (sal) and daughters against dpp (dad) emerge. dipalmitoylphosphatidylserine 195-198 decapentaplegic Drosophila melanogaster 78-81 26282001-0 2016 MicroRNA-218 regulates cisplatin (DPP) chemosensitivity in non-small cell lung cancer by targeting RUNX2. dipalmitoylphosphatidylserine 34-37 RUNX family transcription factor 2 Homo sapiens 99-104 26455410-8 2015 inx2 interacts genetically with the Dpp pathway and we find that proper activation of the Dpp pathway transducer Mad at the furrow and expression of Dpp receptors Thickveins and Punt in the anterior disc compartment require inx2. dipalmitoylphosphatidylserine 36-39 Innexin 2 Drosophila melanogaster 0-4 26455410-8 2015 inx2 interacts genetically with the Dpp pathway and we find that proper activation of the Dpp pathway transducer Mad at the furrow and expression of Dpp receptors Thickveins and Punt in the anterior disc compartment require inx2. dipalmitoylphosphatidylserine 36-39 Innexin 2 Drosophila melanogaster 224-228 26455410-8 2015 inx2 interacts genetically with the Dpp pathway and we find that proper activation of the Dpp pathway transducer Mad at the furrow and expression of Dpp receptors Thickveins and Punt in the anterior disc compartment require inx2. dipalmitoylphosphatidylserine 90-93 Innexin 2 Drosophila melanogaster 0-4 26455410-8 2015 inx2 interacts genetically with the Dpp pathway and we find that proper activation of the Dpp pathway transducer Mad at the furrow and expression of Dpp receptors Thickveins and Punt in the anterior disc compartment require inx2. dipalmitoylphosphatidylserine 90-93 Innexin 2 Drosophila melanogaster 224-228 26455410-9 2015 We further show that inx2 is required for the transcriptional activation of dpp and punt in the eye disc. dipalmitoylphosphatidylserine 76-79 Innexin 2 Drosophila melanogaster 21-25 26599604-4 2015 The position of the zone that is predicted based on quantitative data for the Dpp morphogen corresponds to where the Dpp-dependent gene expression boundaries of spalt (sal) and daughters against dpp (dad) emerge. dipalmitoylphosphatidylserine 195-198 decapentaplegic Drosophila melanogaster 117-120 26599604-4 2015 The position of the zone that is predicted based on quantitative data for the Dpp morphogen corresponds to where the Dpp-dependent gene expression boundaries of spalt (sal) and daughters against dpp (dad) emerge. dipalmitoylphosphatidylserine 195-198 spalt major Drosophila melanogaster 161-166 26196531-3 2015 The floating film was transferred onto a substrate by the Schaefer method, and then the film was immersed in a [Ru(dpp)3]Cl2 (dpp = 4,7-diphenyl-1,10-phenanthroline) solution. dipalmitoylphosphatidylserine 115-118 endogenous retrovirus group W member 5 Homo sapiens 121-124 26071844-4 2015 In our work, by comparing the mixed Cyt c-anionic (DPPS) and Cyt c-zwitterionic (DPPC/DPPE) monolayers, the adsorption capacity of Cyt c on lipid monolayers is DPPS>DPPE>DPPC, which is attributed to their different headgroup structures. dipalmitoylphosphatidylserine 160-164 cytochrome c, somatic Homo sapiens 61-66 26071844-4 2015 In our work, by comparing the mixed Cyt c-anionic (DPPS) and Cyt c-zwitterionic (DPPC/DPPE) monolayers, the adsorption capacity of Cyt c on lipid monolayers is DPPS>DPPE>DPPC, which is attributed to their different headgroup structures. dipalmitoylphosphatidylserine 160-164 cytochrome c, somatic Homo sapiens 61-66 26293305-3 2015 In the absence of BMP signalling, one GSC daughter differentiates into a cystoblast (CB) and this fate is stabilised by Brain tumour (Brat) and Pumilio (Pum)-mediated post-transcriptional repression of mRNAs, including that encoding the Dpp transducer, Mad. dipalmitoylphosphatidylserine 237-240 brain tumor Drosophila melanogaster 134-138 26293305-3 2015 In the absence of BMP signalling, one GSC daughter differentiates into a cystoblast (CB) and this fate is stabilised by Brain tumour (Brat) and Pumilio (Pum)-mediated post-transcriptional repression of mRNAs, including that encoding the Dpp transducer, Mad. dipalmitoylphosphatidylserine 237-240 pumilio Drosophila melanogaster 144-151 26293305-3 2015 In the absence of BMP signalling, one GSC daughter differentiates into a cystoblast (CB) and this fate is stabilised by Brain tumour (Brat) and Pumilio (Pum)-mediated post-transcriptional repression of mRNAs, including that encoding the Dpp transducer, Mad. dipalmitoylphosphatidylserine 237-240 pumilio Drosophila melanogaster 144-147 26293305-5 2015 Here, we identify the Medea and schnurri mRNAs, which encode transcriptional regulators required for activation and/or repression of Dpp target genes, as additional Pum-Brat targets, suggesting that tripartite repression of the transducers is deployed to desensitise the CB to Dpp. dipalmitoylphosphatidylserine 277-280 pumilio Drosophila melanogaster 165-168 26293305-8 2015 Finally, we show generality of the mechanism by demonstrating that Brat also attenuates pMad and Dpp signalling range in the early embryo. dipalmitoylphosphatidylserine 97-100 brain tumor Drosophila melanogaster 67-71 26325078-1 2015 We describe the production of stable DPPC and DPPC:DPPS-proteoliposomes harboring annexin V (AnxA5) and tissue-nonspecific alkaline phosphatase (TNAP) and their use to investigate whether the presence of AnxA5 impacts the kinetic parameters for hydrolysis of TNAP substrates at physiological pH. dipalmitoylphosphatidylserine 51-55 annexin A5 Homo sapiens 82-91 26325078-1 2015 We describe the production of stable DPPC and DPPC:DPPS-proteoliposomes harboring annexin V (AnxA5) and tissue-nonspecific alkaline phosphatase (TNAP) and their use to investigate whether the presence of AnxA5 impacts the kinetic parameters for hydrolysis of TNAP substrates at physiological pH. dipalmitoylphosphatidylserine 51-55 annexin A5 Homo sapiens 93-98 26325078-1 2015 We describe the production of stable DPPC and DPPC:DPPS-proteoliposomes harboring annexin V (AnxA5) and tissue-nonspecific alkaline phosphatase (TNAP) and their use to investigate whether the presence of AnxA5 impacts the kinetic parameters for hydrolysis of TNAP substrates at physiological pH. dipalmitoylphosphatidylserine 51-55 annexin A5 Homo sapiens 204-209 26325078-4 2015 The presence of 10% DPPS in DPPC-liposomes causes a broadening of the transition peaks, with AnxA5 and TNAP promoting a decrease in DeltaH values. dipalmitoylphosphatidylserine 20-24 annexin A5 Homo sapiens 93-98 26325078-5 2015 AnxA5 was able to mediate Ca(2+)-influx into the DPPC and DPPC:DPPS 10%-vesicles at physiological Ca(2+) concentrations (~2 mM). dipalmitoylphosphatidylserine 63-67 annexin A5 Homo sapiens 0-5 25995263-10 2015 Unexpectedly, however, DP-PI(4,5)P2 still promoted recruitment of Gag, but not PHPLCdelta1, to the dipalmitoyl-phosphatidylserine-enriched gel phase of these GUVs. dipalmitoylphosphatidylserine 99-129 Pr55(Gag) Human immunodeficiency virus 1 66-69 26174668-0 2015 Intersex (ix) mutations of Drosophila melanogaster cause nonrandom cell death in genital disc and can induce tumours in genitals in response to decapentaplegic (dpp(disk)) mutations. dipalmitoylphosphatidylserine 161-164 intersex Drosophila melanogaster 0-8 24390239-5 2014 The data revealed DEHP exposure significantly reduced the percentage of methylated CpG sites in Igf2r and Peg3 differentially methylated regions (DMRs) in primordial germ cells from female and male fetal mouse, particularly, in the oocytes of 21 dpp mice (F1), which were produced by the pregnant micetreated with DEHP. dipalmitoylphosphatidylserine 246-249 paternally expressed 3 Mus musculus 106-110 26005834-4 2015 On tissue damage, haemocytes are recruited to the intestine and secrete the BMP homologue DPP, inducing ISC proliferation by activating the type I receptor Saxophone and the Smad homologue SMOX. dipalmitoylphosphatidylserine 90-93 Smad on X Drosophila melanogaster 189-193 25661976-7 2015 In this communication, we address the issue by applying methano indene fullerene, MIF, a bis-functionalised C60 fullerene that has a LUMO level 140 mV higher than PCBM, in solution processed SMOSCs with a well known small molecule donor, DPP(TBFu)2. dipalmitoylphosphatidylserine 238-241 macrophage migration inhibitory factor Homo sapiens 82-85 25377173-1 2014 The BMP ligand Dpp, operates as a long range morphogen to control many important functions during Drosophila development from tissue patterning to growth. dipalmitoylphosphatidylserine 15-18 decapentaplegic Drosophila melanogaster 4-7 24658126-5 2014 Simultaneous knockdown of dpp, encoding a BMP, in ECs can partially rescue the germ cell differentiation defect, indicating that Piwi is required in ECs to repress dpp. dipalmitoylphosphatidylserine 26-29 P-element induced wimpy testis Drosophila melanogaster 129-133 24658126-5 2014 Simultaneous knockdown of dpp, encoding a BMP, in ECs can partially rescue the germ cell differentiation defect, indicating that Piwi is required in ECs to repress dpp. dipalmitoylphosphatidylserine 164-167 P-element induced wimpy testis Drosophila melanogaster 129-133 24618900-4 2014 Two BMP ligands, Dpp and Gbb, are produced by enterocytes and act in conjunction to promote ISC self-renewal by antagonizing Notch signaling. dipalmitoylphosphatidylserine 17-20 glass bottom boat Drosophila melanogaster 4-7 24559319-2 2014 The osteogenic human bone morphogenetic protein-2 (hBMP-2) and its Drosophila DPP homolog were the early successful cases of refolding into functional form. dipalmitoylphosphatidylserine 78-81 bone morphogenetic protein 2 Homo sapiens 21-49 24559319-2 2014 The osteogenic human bone morphogenetic protein-2 (hBMP-2) and its Drosophila DPP homolog were the early successful cases of refolding into functional form. dipalmitoylphosphatidylserine 78-81 bone morphogenetic protein 2 Homo sapiens 51-57 23796903-0 2013 Mummy, A UDP-N-acetylglucosamine pyrophosphorylase, modulates DPP signaling in the embryonic epidermis of Drosophila. dipalmitoylphosphatidylserine 62-65 mummy Drosophila melanogaster 0-5 25045716-5 2014 In this work we discuss these aspects for the spatial TAU-leaping in crowded compartments (STAUCC) simulator, a voxel-based method for the stochastic simulation of reaction-diffusion processes which relies on the Stau-DPP algorithm. dipalmitoylphosphatidylserine 218-221 staufen double-stranded RNA binding protein 1 Homo sapiens 213-217 23946237-1 2013 Two new high-performance DPP-containing donor molecules employing a molecular architecture with three DPP chromorphores (tri-DPP) in conjugated backbones are synthesized and characterized. dipalmitoylphosphatidylserine 25-28 tRNA-Ile (anticodon AAT) 9-1 Homo sapiens 121-124 23946237-1 2013 Two new high-performance DPP-containing donor molecules employing a molecular architecture with three DPP chromorphores (tri-DPP) in conjugated backbones are synthesized and characterized. dipalmitoylphosphatidylserine 102-105 tRNA-Ile (anticodon AAT) 9-1 Homo sapiens 121-124 24086064-5 2013 This potential of Myc is harnessed by many different signaling pathways, involving, among others, Wg, Dpp, Hpo, ecdysone, insulin, and mTOR. dipalmitoylphosphatidylserine 102-105 Myc Drosophila melanogaster 18-21 24218631-4 2013 Contrary to our initial hypothesis, improving the affinity of Ci/Gli sites in enhancers of dpp, wingless and stripe, by transplanting optimal sites from the patched gene, did not result in ectopic responses to Hh signalling. dipalmitoylphosphatidylserine 91-94 cubitus interruptus Drosophila melanogaster 62-68 23792115-0 2013 optix functions as a link between the retinal determination network and the dpp pathway to control morphogenetic furrow progression in Drosophila. dipalmitoylphosphatidylserine 76-79 optix Drosophila melanogaster 0-5 23792115-0 2013 optix functions as a link between the retinal determination network and the dpp pathway to control morphogenetic furrow progression in Drosophila. dipalmitoylphosphatidylserine 76-79 furrow Drosophila melanogaster 113-119 23792115-9 2013 Specifically, although unaffected during MF initiation, expression of dpp in the MF is dramatically reduced in optix mutant clones. dipalmitoylphosphatidylserine 70-73 optix Drosophila melanogaster 111-116 23792115-11 2013 Furthermore, positive feedback between optix and sine oculis and eyes absent is observed, which is likely mediated through dpp signaling pathway. dipalmitoylphosphatidylserine 123-126 optix Drosophila melanogaster 39-44 23792115-12 2013 Together with the observation that optix expression does not depend on hh or dpp, we propose that optix functions together with hh to regulate dpp in the MF, serving as a link between the RD network and the patterning pathways controlling normal retinal development. dipalmitoylphosphatidylserine 143-146 optix Drosophila melanogaster 35-40 23792115-12 2013 Together with the observation that optix expression does not depend on hh or dpp, we propose that optix functions together with hh to regulate dpp in the MF, serving as a link between the RD network and the patterning pathways controlling normal retinal development. dipalmitoylphosphatidylserine 143-146 optix Drosophila melanogaster 98-103 23891114-0 2013 Drosophila piwi mutants exhibit germline stem cell tumors that are sustained by elevated Dpp signaling. dipalmitoylphosphatidylserine 89-92 P-element induced wimpy testis Drosophila melanogaster 11-15 23891688-5 2013 In ChIP experiments using larval wing discs, Zelda was found to bind to a region of the optomotor-blind gene, suggesting an interaction with a Dpp target that promotes wing growth and patterning. dipalmitoylphosphatidylserine 143-146 zelda Drosophila melanogaster 45-50 23891114-2 2013 It was proposed that somatic Piwi maintains germline stem cells (GSCs) by promoting Dpp signaling, presumably via cap cells that form the somatic niche for GSCs [3-5]. dipalmitoylphosphatidylserine 84-87 P-element induced wimpy testis Drosophila melanogaster 29-33 23891114-4 2013 Multiple readouts demonstrated hyperactive Dpp signaling in piwi mutants, including the failure to express the germline differentiation factor bag-of-marbles (bam), and restoration of bam expression relieved piwi GSC-like tumors. dipalmitoylphosphatidylserine 43-46 P-element induced wimpy testis Drosophila melanogaster 60-64 23891114-9 2013 Our data indicate that loss of Piwi causes defects in ICs and escort cells, leading to ectopic Dpp signaling and consequent blockage of GSC differentiation. dipalmitoylphosphatidylserine 95-98 P-element induced wimpy testis Drosophila melanogaster 31-35 23810561-3 2013 Here, we identify a role for the BMP-like Dpp signaling pathway in diversifying regenerative processes in the adult gastrointestinal tract of Drosophila. dipalmitoylphosphatidylserine 42-45 decapentaplegic Drosophila melanogaster 33-36 23644984-8 2013 In dairy goat, the expression levels of Boule and Stra8 would rise with the increase of age, but the expression level of Nanos2 in 90 dpp and adult testis had not shown a clear change. dipalmitoylphosphatidylserine 134-137 nanos homolog 2 Capra hircus 121-127 23624310-8 2013 Reducing dpp or dally levels suppresses the germ cell differentiation defects, indicating that dBre1 limits BMP signaling activities for the differentiation control. dipalmitoylphosphatidylserine 9-12 Bre1 Drosophila melanogaster 95-100 23624310-8 2013 Reducing dpp or dally levels suppresses the germ cell differentiation defects, indicating that dBre1 limits BMP signaling activities for the differentiation control. dipalmitoylphosphatidylserine 9-12 decapentaplegic Drosophila melanogaster 108-111 23499655-8 2013 We show that the Neurogenic Ectoderm Enhancer (NEE) at vnd takes additional input from the complementary Dpp gradient via a conserved Schnurri/Mad/Medea silencer element (SSE) unlike NEEs at brk, sog, rho, and vn. dipalmitoylphosphatidylserine 105-108 ventral nervous system defective Drosophila melanogaster 55-58 23618553-1 2013 A potential adverse effect of dipeptidyl peptidase-4 inhibitors (DPP-4i) on the pancreas remains controversial. dipalmitoylphosphatidylserine 65-68 dipeptidyl peptidase 4 Homo sapiens 30-52 23579691-4 2013 We previously demonstrated that transcriptional regulation of myosin from the zipper (zip) locus in both the epidermis and the AS involves the expression of Ack family tyrosine kinases in the AS in conjunction with Dpp secreted from the epidermis. dipalmitoylphosphatidylserine 215-218 zipper Drosophila melanogaster 62-68 23508548-6 2013 The results first revealed the expression patterns of Boule, Stra8, P53 and miR-34c in 30 dpp, 90 dpp and adult testes of dairy goats. dipalmitoylphosphatidylserine 90-93 protein boule-like Capra hircus 54-59 23508548-6 2013 The results first revealed the expression patterns of Boule, Stra8, P53 and miR-34c in 30 dpp, 90 dpp and adult testes of dairy goats. dipalmitoylphosphatidylserine 90-93 stimulated by retinoic acid gene 8 protein homolog Capra hircus 61-66 23508548-6 2013 The results first revealed the expression patterns of Boule, Stra8, P53 and miR-34c in 30 dpp, 90 dpp and adult testes of dairy goats. dipalmitoylphosphatidylserine 90-93 microRNA 34c Capra hircus 76-83 23508548-6 2013 The results first revealed the expression patterns of Boule, Stra8, P53 and miR-34c in 30 dpp, 90 dpp and adult testes of dairy goats. dipalmitoylphosphatidylserine 98-101 protein boule-like Capra hircus 54-59 23508548-6 2013 The results first revealed the expression patterns of Boule, Stra8, P53 and miR-34c in 30 dpp, 90 dpp and adult testes of dairy goats. dipalmitoylphosphatidylserine 98-101 cellular tumor antigen p53 Capra hircus 68-71 23508548-6 2013 The results first revealed the expression patterns of Boule, Stra8, P53 and miR-34c in 30 dpp, 90 dpp and adult testes of dairy goats. dipalmitoylphosphatidylserine 98-101 microRNA 34c Capra hircus 76-83 23170960-8 2013 This review article focuses on the status of advanced lead candidates of DPP group and their binding affinity with the active site residue of target structure which help in discovery of potent and selective DPP-4 inhibitors by lead optimization approach. dipalmitoylphosphatidylserine 73-76 dipeptidyl peptidase 4 Homo sapiens 207-212 23579691-4 2013 We previously demonstrated that transcriptional regulation of myosin from the zipper (zip) locus in both the epidermis and the AS involves the expression of Ack family tyrosine kinases in the AS in conjunction with Dpp secreted from the epidermis. dipalmitoylphosphatidylserine 215-218 unzipped Drosophila melanogaster 78-81 23579691-7 2013 Our studies demonstrate that Egfr is required to negatively regulate epidermal expression of dpp during DC. dipalmitoylphosphatidylserine 93-96 Epidermal growth factor receptor Drosophila melanogaster 29-33 23447049-3 2013 P110 was demonstrated to enhance the effect of DPP in vitro and in vivo. dipalmitoylphosphatidylserine 47-50 endogenous retrovirus group K member 15 Homo sapiens 0-4 23138973-2 2013 GLP-1 underwent 75 % degradation by DPP-IV over 8 h, whereas (Val(8))GLP-1 and (Val(8))GLP-1-Glu-PAL remained intact. dipalmitoylphosphatidylserine 36-39 glucagon Mus musculus 0-5 24185376-0 2013 Novel water-soluble prodrugs of acyclovir cleavable by the dipeptidyl-peptidase IV (DPP IV/CD26) enzyme. dipalmitoylphosphatidylserine 84-87 dipeptidyl peptidase 4 Homo sapiens 59-82 23150675-5 2013 More profoundly, ectopic expression of MTMR4 or its Drosophila homolog CG3632 genetically interacted with BMP/Dpp signaling axis in regulation of the vein development of Drosophila wings. dipalmitoylphosphatidylserine 110-113 decapentaplegic Drosophila melanogaster 106-109 23369712-7 2013 Depletion of dpp expression in tracheal cells phenocopies the Dpp loss-of-function defects in ECs. dipalmitoylphosphatidylserine 13-16 decapentaplegic Drosophila melanogaster 62-65 24185376-0 2013 Novel water-soluble prodrugs of acyclovir cleavable by the dipeptidyl-peptidase IV (DPP IV/CD26) enzyme. dipalmitoylphosphatidylserine 84-87 dipeptidyl peptidase 4 Homo sapiens 91-95 23686701-1 2013 Neutral endopeptidase (NEP/CD10) and dipeptidyl peptidase IV (DPP IV/CD26) are both ubiquitous glycopeptidases which play important roles in tumor pathogenesis and development. dipalmitoylphosphatidylserine 62-65 membrane metalloendopeptidase Homo sapiens 23-26 23686701-1 2013 Neutral endopeptidase (NEP/CD10) and dipeptidyl peptidase IV (DPP IV/CD26) are both ubiquitous glycopeptidases which play important roles in tumor pathogenesis and development. dipalmitoylphosphatidylserine 62-65 membrane metalloendopeptidase Homo sapiens 27-31 23686701-1 2013 Neutral endopeptidase (NEP/CD10) and dipeptidyl peptidase IV (DPP IV/CD26) are both ubiquitous glycopeptidases which play important roles in tumor pathogenesis and development. dipalmitoylphosphatidylserine 62-65 dipeptidyl peptidase 4 Homo sapiens 37-60 23686701-1 2013 Neutral endopeptidase (NEP/CD10) and dipeptidyl peptidase IV (DPP IV/CD26) are both ubiquitous glycopeptidases which play important roles in tumor pathogenesis and development. dipalmitoylphosphatidylserine 62-65 dipeptidyl peptidase 4 Homo sapiens 69-73 22898294-5 2012 Expression domain of brk during early blastdermal stages is defined through antagonistic interaction with dpp, and expression domains of dpp and brk in the early blastoderm include prospective hindgut domain. dipalmitoylphosphatidylserine 106-109 brinker Drosophila melanogaster 21-24 23014114-1 2012 A new phosphorescent chemosensor for Hg(2+) and acetonitrile (MeCN) based on iridium(III) complex Ir(dpp)(2)(dtc) (Ir1, dppH = 4,6-diphenylpyrimidine, dtcH = diethyl dithiocarbamic acid) was realized. dipalmitoylphosphatidylserine 101-104 nischarin Homo sapiens 115-118 22111653-5 2012 CDH1 mRNA was highly expressed before PND 6, but decreased dramatically on PND 8, then gradually increased until it started to decrease after 12 dpp. dipalmitoylphosphatidylserine 145-148 cadherin 1 Rattus norvegicus 0-4 22796561-3 2012 Immunohistochemistry, quantitative PCR and western blots were performed to localize and quantify the expressional characteristics of Lhx8 in oocytes of 13.5 dpc (day post coitum), 17.5 dpc, 0 dpp (day post partum), 3 dpp, 7 dpp and 14 dpp. dipalmitoylphosphatidylserine 217-220 LIM homeobox protein 8 Mus musculus 133-137 22796561-3 2012 Immunohistochemistry, quantitative PCR and western blots were performed to localize and quantify the expressional characteristics of Lhx8 in oocytes of 13.5 dpc (day post coitum), 17.5 dpc, 0 dpp (day post partum), 3 dpp, 7 dpp and 14 dpp. dipalmitoylphosphatidylserine 217-220 LIM homeobox protein 8 Mus musculus 133-137 22796561-3 2012 Immunohistochemistry, quantitative PCR and western blots were performed to localize and quantify the expressional characteristics of Lhx8 in oocytes of 13.5 dpc (day post coitum), 17.5 dpc, 0 dpp (day post partum), 3 dpp, 7 dpp and 14 dpp. dipalmitoylphosphatidylserine 217-220 LIM homeobox protein 8 Mus musculus 133-137 22705500-6 2012 This phenotype correlates with overexpression of the morphogen Dpp in ptc,Ark double-mutant cells, leading to elevated phosphorylation of the Dpp pathway effector Mad (p-Mad) in cells surrounding ptc,Ark mutant clones. dipalmitoylphosphatidylserine 63-66 Death-associated APAF1-related killer Drosophila melanogaster 74-77 22705500-6 2012 This phenotype correlates with overexpression of the morphogen Dpp in ptc,Ark double-mutant cells, leading to elevated phosphorylation of the Dpp pathway effector Mad (p-Mad) in cells surrounding ptc,Ark mutant clones. dipalmitoylphosphatidylserine 63-66 Death-associated APAF1-related killer Drosophila melanogaster 200-203 22705500-6 2012 This phenotype correlates with overexpression of the morphogen Dpp in ptc,Ark double-mutant cells, leading to elevated phosphorylation of the Dpp pathway effector Mad (p-Mad) in cells surrounding ptc,Ark mutant clones. dipalmitoylphosphatidylserine 142-145 Death-associated APAF1-related killer Drosophila melanogaster 74-77 22967030-9 2012 RESULTS: The rats treated with doxorubicin showed reduction of transferrin labeling in the seminiferous epithelium at 40 and 64 dpp, suggesting that Sertoli cell function is altered in these rats. dipalmitoylphosphatidylserine 128-131 transferrin Rattus norvegicus 63-74 23213425-4 2012 We identified Ush by gene expression microarray analysis of Dpp signaling targets and show that Ush mediates some DC functions of Dpp. dipalmitoylphosphatidylserine 130-133 u-shaped Drosophila melanogaster 14-17 22711472-4 2012 The thick calvarium and thick skin were clues to the clinical diagnosis of MS. A heterozygous mutation in the mothers-against-DPP homolog 4 (SMAD4) gene has been reported to cause MS. We sequenced SMAD4 using standard PCR-based technique and identified a recurrent mutation (p.Ile500 Thr). dipalmitoylphosphatidylserine 126-129 SMAD family member 4 Homo sapiens 141-146 22711472-4 2012 The thick calvarium and thick skin were clues to the clinical diagnosis of MS. A heterozygous mutation in the mothers-against-DPP homolog 4 (SMAD4) gene has been reported to cause MS. We sequenced SMAD4 using standard PCR-based technique and identified a recurrent mutation (p.Ile500 Thr). dipalmitoylphosphatidylserine 126-129 SMAD family member 4 Homo sapiens 197-202 22692886-4 2012 To illustrate this point, I discuss three examples: the Dpp gradient during growth of the Drosophila wing imaginal disc; the Polycomb-based epigenetic silencing during vernalization in plants; and the Notch-dependent somite segmentation clock. dipalmitoylphosphatidylserine 56-59 Notch Drosophila melanogaster 201-206 22573617-4 2012 Cv-d binds to the BMPs Dpp and Gbb through its Vg domain, and to heparan sulfate proteoglycans, which are well-known for their role in BMP movement and accumulation in the wing. dipalmitoylphosphatidylserine 23-26 crossveinless d Drosophila melanogaster 0-4 22573617-4 2012 Cv-d binds to the BMPs Dpp and Gbb through its Vg domain, and to heparan sulfate proteoglycans, which are well-known for their role in BMP movement and accumulation in the wing. dipalmitoylphosphatidylserine 23-26 glass bottom boat Drosophila melanogaster 18-21 23213425-4 2012 We identified Ush by gene expression microarray analysis of Dpp signaling targets and show that Ush mediates some DC functions of Dpp. dipalmitoylphosphatidylserine 60-63 u-shaped Drosophila melanogaster 14-17 23213425-4 2012 We identified Ush by gene expression microarray analysis of Dpp signaling targets and show that Ush mediates some DC functions of Dpp. dipalmitoylphosphatidylserine 130-133 u-shaped Drosophila melanogaster 96-99 22104727-8 2012 The levels of Stat3 target oncogenes such as Bcl-2 and c-Myc were decreased with DPP, a Stat3 inhibitor, treatment, while the expression of tumor suppressor p53 was increased. dipalmitoylphosphatidylserine 81-84 signal transducer and activator of transcription 3 Homo sapiens 14-19 22311982-8 2012 Taken together, the results presented here demonstrate that the expression and localization of the DPP accessory subunits are independent of Kv4 alpha subunits and further that the DPP6/10 and KChIP accessory subunits independently stabilize the surface expression of Kv4.2. dipalmitoylphosphatidylserine 99-102 dipeptidylpeptidase 6 Mus musculus 181-188 22311982-8 2012 Taken together, the results presented here demonstrate that the expression and localization of the DPP accessory subunits are independent of Kv4 alpha subunits and further that the DPP6/10 and KChIP accessory subunits independently stabilize the surface expression of Kv4.2. dipalmitoylphosphatidylserine 99-102 potassium voltage-gated channel, Shal-related family, member 2 Mus musculus 268-273 22104727-8 2012 The levels of Stat3 target oncogenes such as Bcl-2 and c-Myc were decreased with DPP, a Stat3 inhibitor, treatment, while the expression of tumor suppressor p53 was increased. dipalmitoylphosphatidylserine 81-84 BCL2 apoptosis regulator Homo sapiens 45-50 22331866-9 2012 Dpp antagonizes activity of wingless (Wg)/Wnt signaling, which positively regulates the number of PSC cells via the control of Dmyc expression. dipalmitoylphosphatidylserine 0-3 Myc Drosophila melanogaster 127-131 22104727-8 2012 The levels of Stat3 target oncogenes such as Bcl-2 and c-Myc were decreased with DPP, a Stat3 inhibitor, treatment, while the expression of tumor suppressor p53 was increased. dipalmitoylphosphatidylserine 81-84 MYC proto-oncogene, bHLH transcription factor Homo sapiens 55-60 22104727-8 2012 The levels of Stat3 target oncogenes such as Bcl-2 and c-Myc were decreased with DPP, a Stat3 inhibitor, treatment, while the expression of tumor suppressor p53 was increased. dipalmitoylphosphatidylserine 81-84 signal transducer and activator of transcription 3 Homo sapiens 88-93 22104727-8 2012 The levels of Stat3 target oncogenes such as Bcl-2 and c-Myc were decreased with DPP, a Stat3 inhibitor, treatment, while the expression of tumor suppressor p53 was increased. dipalmitoylphosphatidylserine 81-84 tumor protein p53 Homo sapiens 157-160 22737084-5 2012 CBP peaks in mutant embryos lacking nuclear Dorsal are best correlated with TGF-ss/Dpp-signaling and Smad-protein binding. dipalmitoylphosphatidylserine 83-86 sarcoplasmic calcium-binding protein Drosophila melanogaster 0-3 22114909-0 2011 Excessive Dpp signaling induces cardial apoptosis through dTAK1 and dJNK during late embryogenesis of Drosophila. dipalmitoylphosphatidylserine 10-13 TGF-beta activated kinase 1 Drosophila melanogaster 58-63 23300903-5 2012 Claudin 11 mRNA expression also was significantly reduced in FSH-R(-/-) testes at 0 and 8 dpp, whereas the mRNA levels of other Sertoli cell markers (Transferrin and Desert hedgehog) were comparable in FSH-R(-/-) and wild type testes. dipalmitoylphosphatidylserine 90-93 follicle stimulating hormone receptor Mus musculus 61-66 23300903-6 2012 Conversely, AMH mRNA and protein levels were higher at birth, comparable at 6 dpp and then significantly lower in FSH-R(-/-) testes at 8-10 dpp in FSH-R(-/-) mice than in controls. dipalmitoylphosphatidylserine 78-81 anti-Mullerian hormone Mus musculus 12-15 23300903-6 2012 Conversely, AMH mRNA and protein levels were higher at birth, comparable at 6 dpp and then significantly lower in FSH-R(-/-) testes at 8-10 dpp in FSH-R(-/-) mice than in controls. dipalmitoylphosphatidylserine 140-143 anti-Mullerian hormone Mus musculus 12-15 22701670-4 2012 Silencing of Tap42 also altered multiple signaling pathways (HH, JNK and DPP) and triggered apoptosis in wing imaginal discs. dipalmitoylphosphatidylserine 73-76 Two A-associated protein of 42kDa Drosophila melanogaster 13-18 22114909-9 2011 The hyperactivated DJNK was attributed to be the cause of Dpp/DTAK1-induced apoptosis because overexpression of a dominant negative DJNK, basket (bskDN), suppressed cell death induced by Dpp or DTAK1. dipalmitoylphosphatidylserine 58-61 basket Drosophila melanogaster 132-136 22114909-0 2011 Excessive Dpp signaling induces cardial apoptosis through dTAK1 and dJNK during late embryogenesis of Drosophila. dipalmitoylphosphatidylserine 10-13 basket Drosophila melanogaster 68-72 22114909-6 2011 Aberrant dpp signaling is likely to contribute to the cardial phenotype found in raw mutants, because expression of dpp or constitutively activated thickven (tkvCA), the type I receptor of Dpp, induced a raw-like phenotype. dipalmitoylphosphatidylserine 189-192 decapentaplegic Drosophila melanogaster 9-12 22114909-9 2011 The hyperactivated DJNK was attributed to be the cause of Dpp/DTAK1-induced apoptosis because overexpression of a dominant negative DJNK, basket (bskDN), suppressed cell death induced by Dpp or DTAK1. dipalmitoylphosphatidylserine 58-61 TGF-beta activated kinase 1 Drosophila melanogaster 194-199 22114909-9 2011 The hyperactivated DJNK was attributed to be the cause of Dpp/DTAK1-induced apoptosis because overexpression of a dominant negative DJNK, basket (bskDN), suppressed cell death induced by Dpp or DTAK1. dipalmitoylphosphatidylserine 187-190 basket Drosophila melanogaster 19-23 22114909-6 2011 Aberrant dpp signaling is likely to contribute to the cardial phenotype found in raw mutants, because expression of dpp or constitutively activated thickven (tkvCA), the type I receptor of Dpp, induced a raw-like phenotype. dipalmitoylphosphatidylserine 189-192 decapentaplegic Drosophila melanogaster 116-119 22114909-9 2011 The hyperactivated DJNK was attributed to be the cause of Dpp/DTAK1-induced apoptosis because overexpression of a dominant negative DJNK, basket (bskDN), suppressed cell death induced by Dpp or DTAK1. dipalmitoylphosphatidylserine 187-190 TGF-beta activated kinase 1 Drosophila melanogaster 62-67 22114909-9 2011 The hyperactivated DJNK was attributed to be the cause of Dpp/DTAK1-induced apoptosis because overexpression of a dominant negative DJNK, basket (bskDN), suppressed cell death induced by Dpp or DTAK1. dipalmitoylphosphatidylserine 187-190 basket Drosophila melanogaster 132-136 22114909-9 2011 The hyperactivated DJNK was attributed to be the cause of Dpp/DTAK1-induced apoptosis because overexpression of a dominant negative DJNK, basket (bskDN), suppressed cell death induced by Dpp or DTAK1. dipalmitoylphosphatidylserine 58-61 basket Drosophila melanogaster 19-23 22114909-11 2011 CONCLUSIONS: We find that ectopic Dpp led to DJNK-dependent cardial apoptosis through the non-canonical TGF-beta pathway during late embryogenesis of Drosophila. dipalmitoylphosphatidylserine 34-37 basket Drosophila melanogaster 45-49 22114909-9 2011 The hyperactivated DJNK was attributed to be the cause of Dpp/DTAK1-induced apoptosis because overexpression of a dominant negative DJNK, basket (bskDN), suppressed cell death induced by Dpp or DTAK1. dipalmitoylphosphatidylserine 58-61 TGF-beta activated kinase 1 Drosophila melanogaster 62-67 21711053-2 2011 The availability of a DPP8-selective compound would be highly instrumental for studying and untwining the biological roles of DPP8 and DPP9 and for the disambiguation of biological effects of nonselective DPP-inhibitors that have mainly been ascribed to blocking of DPPIV"s action. dipalmitoylphosphatidylserine 22-25 dipeptidyl peptidase 8 Homo sapiens 126-130 21671348-7 2011 We compare these findings with data from vertebrates and non-model organisms to discuss how changes in the regulation of Dpp distribution by extracellular modulators may lead to variability in dpp function in different species. dipalmitoylphosphatidylserine 121-124 decapentaplegic Drosophila melanogaster 193-196 21711053-2 2011 The availability of a DPP8-selective compound would be highly instrumental for studying and untwining the biological roles of DPP8 and DPP9 and for the disambiguation of biological effects of nonselective DPP-inhibitors that have mainly been ascribed to blocking of DPPIV"s action. dipalmitoylphosphatidylserine 22-25 dipeptidyl peptidase 9 Homo sapiens 135-139 21711053-2 2011 The availability of a DPP8-selective compound would be highly instrumental for studying and untwining the biological roles of DPP8 and DPP9 and for the disambiguation of biological effects of nonselective DPP-inhibitors that have mainly been ascribed to blocking of DPPIV"s action. dipalmitoylphosphatidylserine 22-25 dipeptidyl peptidase 4 Homo sapiens 266-271 21671915-8 2011 We focused on the inhibitory Smad, daughters against dpp (dad), which is induced by Dpp signaling and negatively regulates Dpp activity. dipalmitoylphosphatidylserine 53-56 Mothers against dpp Drosophila melanogaster 29-33 21690388-6 2011 Targeted expression of an active form of Msn in the wing imaginal disk disrupted activation of endogenous MAD by Dpp and expression of the Dpp/MAD target gene. dipalmitoylphosphatidylserine 113-116 misshapen Drosophila melanogaster 41-44 21690388-6 2011 Targeted expression of an active form of Msn in the wing imaginal disk disrupted activation of endogenous MAD by Dpp and expression of the Dpp/MAD target gene. dipalmitoylphosphatidylserine 139-142 misshapen Drosophila melanogaster 41-44 21671915-8 2011 We focused on the inhibitory Smad, daughters against dpp (dad), which is induced by Dpp signaling and negatively regulates Dpp activity. dipalmitoylphosphatidylserine 53-56 Daughters against dpp Drosophila melanogaster 58-61 21671915-8 2011 We focused on the inhibitory Smad, daughters against dpp (dad), which is induced by Dpp signaling and negatively regulates Dpp activity. dipalmitoylphosphatidylserine 53-56 decapentaplegic Drosophila melanogaster 84-87 21558376-0 2011 DPP-mediated TGFbeta signaling regulates juvenile hormone biosynthesis by activating the expression of juvenile hormone acid methyltransferase. dipalmitoylphosphatidylserine 0-3 juvenile hormone acid methyltransferase Drosophila melanogaster 103-142 21671915-8 2011 We focused on the inhibitory Smad, daughters against dpp (dad), which is induced by Dpp signaling and negatively regulates Dpp activity. dipalmitoylphosphatidylserine 53-56 decapentaplegic Drosophila melanogaster 123-126 21146519-8 2011 Among potential targets of the Brahma complex, we identified components of the Notch, EGFR and DPP signaling pathways important for wing development. dipalmitoylphosphatidylserine 95-98 brahma Drosophila melanogaster 31-37 21558376-9 2011 Reduced dpp expression was detected in larvae mutant for Nmdar1, a CA-expressed glutamate receptor. dipalmitoylphosphatidylserine 8-11 NMDA receptor 1 Drosophila melanogaster 57-63 21558376-10 2011 Taken together, we conclude that the neurotransmitter glutamate promotes dpp expression in the CA, which stimulates JH biosynthesis through Tkv and Mad by upregulating jhamt transcription at the early larval stages to prevent premature metamorphosis. dipalmitoylphosphatidylserine 73-76 thickveins Drosophila melanogaster 140-143 21558379-6 2011 We show that En is a short-range signaling molecule that participates in anterior crossvein development, interacting with the Dpp signaling pathway. dipalmitoylphosphatidylserine 126-129 engrailed Drosophila melanogaster 13-15 21194356-4 2011 Examination of DPP expression in rat primary ECs of aortic, endocardial and cardiac microvascular origin revealed the presence of DPPIV-like activity in all cell lysates. dipalmitoylphosphatidylserine 15-18 dipeptidylpeptidase 4 Rattus norvegicus 130-135 21194356-7 2011 The expression of DPPIV and DPP8 was significantly higher in the cardiac microvascular endothelium than in the other ECs, suggesting a more pronounced role of these DPPs in the microvasculature. dipalmitoylphosphatidylserine 165-169 dipeptidyl peptidase 4 Homo sapiens 18-23 21194356-7 2011 The expression of DPPIV and DPP8 was significantly higher in the cardiac microvascular endothelium than in the other ECs, suggesting a more pronounced role of these DPPs in the microvasculature. dipalmitoylphosphatidylserine 165-169 dipeptidyl peptidase 8 Homo sapiens 28-32 21194356-8 2011 In situ, DPP activity in ventricular microvasculature was completely inhibited by sitagliptin, indicating that DPPIV is the predominant DPPIV-like enzyme in this organ. dipalmitoylphosphatidylserine 9-12 dipeptidyl peptidase 4 Homo sapiens 111-116 21194356-8 2011 In situ, DPP activity in ventricular microvasculature was completely inhibited by sitagliptin, indicating that DPPIV is the predominant DPPIV-like enzyme in this organ. dipalmitoylphosphatidylserine 9-12 dipeptidyl peptidase 4 Homo sapiens 136-141 20938986-8 2011 Addition of a combination of DPP-IV and egg-hydrolysate, ovomucoid, or sodium-casein decreased GLP-1 levels. dipalmitoylphosphatidylserine 29-32 glucagon Mus musculus 95-100 21385866-6 2011 We have previously shown that elimination of misspecified cells due to reduced Dpp signaling is achieved by the interaction of the co-repressor NAB with the transcriptional repressor Brk, which in turn induces Jun N-terminal kinase-dependent apoptosis. dipalmitoylphosphatidylserine 79-82 brinker Drosophila melanogaster 183-186 21494610-6 2011 These results show that dTIEG can modulate Dpp signalling. dipalmitoylphosphatidylserine 43-46 cabut Drosophila melanogaster 24-29 21238926-7 2011 Mathematical modeling elucidates bistability of cell fate in the Brat-mediated system, revealing how autoregulation of GSC number can arise from Brat coupling extracellular Dpp regulation to intracellular interpretation. dipalmitoylphosphatidylserine 173-176 brain tumor Drosophila melanogaster 65-69 20926807-4 2011 Activin receptor transcript levels also change, with Acvr1 (encoding ALK2) and Acvr2b (ActRIIB) significantly higher and lower, respectively, at 0 dpp compared with E13.5 and E15.5. dipalmitoylphosphatidylserine 147-150 activin receptor IIB Mus musculus 79-85 20926807-5 2011 Transcripts encoding the signaling mediators Smad1, Smad3, and Smad4 were higher at 0 dpp compared with E13.5 and E15.5, whereas Smad2, Smad5, and Smad7 were lower. dipalmitoylphosphatidylserine 86-89 SMAD family member 1 Mus musculus 45-50 20926807-5 2011 Transcripts encoding the signaling mediators Smad1, Smad3, and Smad4 were higher at 0 dpp compared with E13.5 and E15.5, whereas Smad2, Smad5, and Smad7 were lower. dipalmitoylphosphatidylserine 86-89 SMAD family member 3 Mus musculus 52-57 20926807-5 2011 Transcripts encoding the signaling mediators Smad1, Smad3, and Smad4 were higher at 0 dpp compared with E13.5 and E15.5, whereas Smad2, Smad5, and Smad7 were lower. dipalmitoylphosphatidylserine 86-89 SMAD family member 4 Mus musculus 63-68 21238926-7 2011 Mathematical modeling elucidates bistability of cell fate in the Brat-mediated system, revealing how autoregulation of GSC number can arise from Brat coupling extracellular Dpp regulation to intracellular interpretation. dipalmitoylphosphatidylserine 173-176 brain tumor Drosophila melanogaster 145-149 20442782-7 2010 Clonal analyses revealed that the normal function of dSmad2 is to inhibit the response of wing intervein cells to the extracellular Dpp morphogen gradient that specifies vein formation, as measured by expression of the activated phospho-Mad protein. dipalmitoylphosphatidylserine 132-135 Smad on X Drosophila melanogaster 53-59 20659445-4 2010 In the current studies we demonstrate, by dpp mutant rescue, that cleavage at the S2 site of proDpp is required for development of the wing and leg imaginal discs, whereas cleavage at the S1 site is sufficient to rescue Dpp function in the midgut. dipalmitoylphosphatidylserine 42-45 decapentaplegic Drosophila melanogaster 96-99 20812679-3 2010 In the case of DPPS-OPN patterns, micrometer-sized COM crystals dispersed in saturated aqueous calcium oxalate solutions attached preferentially to the OPN regions, in agreement with other in vitro studies that have suggested a binding affinity of OPN to COM crystal surfaces. dipalmitoylphosphatidylserine 15-19 secreted phosphoprotein 1 Homo sapiens 20-23 20812679-6 2010 Free OPN, a major constituent in urine, adsorbs on COM crystals and suppresses attachment to DPPS, suggesting a link between OPN and reduced attachment of COM crystals to renal epithelium. dipalmitoylphosphatidylserine 93-97 secreted phosphoprotein 1 Homo sapiens 5-8 20495820-4 2010 However, the presence of 5 microg/ml insulin represses the phosphorylation of Akt and the follicular assembly and activation process in the 3 dpp mouse ovaries cultured in vitro. dipalmitoylphosphatidylserine 142-145 thymoma viral proto-oncogene 1 Mus musculus 78-81 20495820-5 2010 Furthermore, in vitro cultures of 3 dpp mouse ovaries with insulin can repress the expression of Pten. dipalmitoylphosphatidylserine 36-39 phosphatase and tensin homolog Mus musculus 97-101 20346356-7 2010 Conversely, a 24-hour TGFbeta2-treatment of explanted wild-type testes, isolated every day from 13.5 dpc until 1 dpp, increased the duration of quiescence. dipalmitoylphosphatidylserine 113-116 transforming growth factor, beta 2 Mus musculus 22-30 19505544-6 2010 Affinity capillary electrophoresis (ACE) revealed an interaction between ghrelin and the negatively charged (DPPC:DPPS) liposomes, whereas only very small affinities were discerned in the other liposomal formulations of ghrelin. dipalmitoylphosphatidylserine 114-118 ghrelin and obestatin prepropeptide Rattus norvegicus 73-80 21368882-2 2010 TIAF1 physically interacts with mothers against DPP homolog 4 (Smad4), and blocks SMAD-dependent promoter activation when overexpressed. dipalmitoylphosphatidylserine 48-51 TGFB1-induced anti-apoptotic factor 1 Homo sapiens 0-5 21368882-2 2010 TIAF1 physically interacts with mothers against DPP homolog 4 (Smad4), and blocks SMAD-dependent promoter activation when overexpressed. dipalmitoylphosphatidylserine 48-51 SMAD family member 4 Homo sapiens 63-68 24489484-8 2010 This property of multiple sensitivities is achieved by using a strategic mix of two oxygen sensitive luminophores ([Ru(dpp)3]2+ and ([Ru(bpy)3]2+) in each pin-printed xerogel sensor element. dipalmitoylphosphatidylserine 118-122 dynein light chain LC8-type 1 Homo sapiens 155-158 20432433-5 2010 RT-PCR and Western blot analyses showed that the expression levels of both Ptma mRNA and corresponding protein decrease in total extracts from 27 to 60 dpp. dipalmitoylphosphatidylserine 152-155 prothymosin alpha Rattus norvegicus 75-79 20381612-1 2010 The goal of this report is to elucidate the contributions of the Drosophila TGF-beta type I receptors TKV and SAX to the activity gradient formed by the two BMP family members DPP and GBB that play important roles in growth and patterning of imaginal discs. dipalmitoylphosphatidylserine 176-179 thickveins Drosophila melanogaster 102-105 20381612-2 2010 Binding studies display preferential interactions of DPP and GBB with homodimers of TKV or SAX, respectively, but also low affinities of both ligands to heterodimers. dipalmitoylphosphatidylserine 53-56 thickveins Drosophila melanogaster 84-87 20381612-8 2010 Since TKV is not distributed equally in wing discs, heterodimers of SAX and TKV play an important role in extending the BMP activity gradient by facilitating DPP diffusion and assisting GBB signaling through functional complexes with type II receptors. dipalmitoylphosphatidylserine 158-161 thickveins Drosophila melanogaster 76-79 20442782-12 2010 We propose that the main function of dActivin/dSmad2 in Drosophila wing development is to antagonize Dpp/Mad signaling. dipalmitoylphosphatidylserine 101-104 Activin-beta Drosophila melanogaster 37-45 20442782-12 2010 We propose that the main function of dActivin/dSmad2 in Drosophila wing development is to antagonize Dpp/Mad signaling. dipalmitoylphosphatidylserine 101-104 Smad on X Drosophila melanogaster 46-52 19382296-8 2009 ZfBMP4 treatment experiments revealed the importance of dpp in establishing the characteristic shape of the bivalve shell anlagen. dipalmitoylphosphatidylserine 56-59 bone morphogenetic protein 4 Danio rerio 0-6 20036228-0 2010 hth maintains the pool of eye progenitors and its downregulation by Dpp and Hh couples retinal fate acquisition with cell cycle exit. dipalmitoylphosphatidylserine 68-71 homothorax Drosophila melanogaster 0-3 20036228-7 2010 Furthermore, we show that the G1 synchronization that characterizes retinal precursors is the result of the spatially controlled repression of hth by Dpp and Hh, and not of an actively induced cell cycle arrest. dipalmitoylphosphatidylserine 150-153 homothorax Drosophila melanogaster 143-146 20042118-5 2009 In addition, TGF-beta signaling by dbl-1/dpp controls ceh-13/labial/Hox1 expression in Bgamma. dipalmitoylphosphatidylserine 41-44 Homeobox protein ceh-13 Caenorhabditis elegans 54-60 20042118-9 2009 We also show that dbl-1/dpp acts either in parallel or downstream of EGF pathway to regulate ceh-13/Hox1 expression in Bgamma. dipalmitoylphosphatidylserine 24-27 Protein dbl-1 Caenorhabditis elegans 18-23 20042118-9 2009 We also show that dbl-1/dpp acts either in parallel or downstream of EGF pathway to regulate ceh-13/Hox1 expression in Bgamma. dipalmitoylphosphatidylserine 24-27 Homeobox protein ceh-13 Caenorhabditis elegans 93-99 19557331-2 2009 Mother against Dpp(Mad) is the founding member of the conserved Smad protein family which specifically transduces the intracellular TGF-beta signaling cascade. dipalmitoylphosphatidylserine 15-18 Medea Drosophila melanogaster 64-68 19366729-0 2009 Dpp signaling promotes the cuboidal-to-columnar shape transition of Drosophila wing disc epithelia by regulating Rho1. dipalmitoylphosphatidylserine 0-3 Rho1 Drosophila melanogaster 113-117 19366729-5 2009 Moreover, we provide evidence that Dpp signaling controls the subcellular distribution of the activities of the small GTPase Rho1 and the regulatory light chain of non-muscle myosin II (MRLC). dipalmitoylphosphatidylserine 35-38 Rho1 Drosophila melanogaster 125-129 19366729-5 2009 Moreover, we provide evidence that Dpp signaling controls the subcellular distribution of the activities of the small GTPase Rho1 and the regulatory light chain of non-muscle myosin II (MRLC). dipalmitoylphosphatidylserine 35-38 zipper Drosophila melanogaster 164-184 19366729-5 2009 Moreover, we provide evidence that Dpp signaling controls the subcellular distribution of the activities of the small GTPase Rho1 and the regulatory light chain of non-muscle myosin II (MRLC). dipalmitoylphosphatidylserine 35-38 spaghetti squash Drosophila melanogaster 186-190 19366729-7 2009 Finally, we demonstrate that a decrease in Rho1 or MRLC activity rescues the shortening of cells with compromised Dpp signaling. dipalmitoylphosphatidylserine 114-117 Rho1 Drosophila melanogaster 43-47 19366729-7 2009 Finally, we demonstrate that a decrease in Rho1 or MRLC activity rescues the shortening of cells with compromised Dpp signaling. dipalmitoylphosphatidylserine 114-117 spaghetti squash Drosophila melanogaster 51-55 19366729-8 2009 Our results identify a cell-autonomous role for Dpp signaling in promoting and maintaining the elongated columnar shape of wing disc cells and suggest that Dpp signaling acts by regulating Rho1 and MRLC. dipalmitoylphosphatidylserine 156-159 Rho1 Drosophila melanogaster 189-193 19366729-8 2009 Our results identify a cell-autonomous role for Dpp signaling in promoting and maintaining the elongated columnar shape of wing disc cells and suggest that Dpp signaling acts by regulating Rho1 and MRLC. dipalmitoylphosphatidylserine 156-159 spaghetti squash Drosophila melanogaster 198-202 19028484-6 2009 We show further that Tin repression and pericardial restriction in the dorsal mesoderm facilitated by Lmd is instructed by a late Decapentaplegic (Dpp) signal that is abolished in embryos carrying the disk region mutation dpp(d6). dipalmitoylphosphatidylserine 222-225 tinman Drosophila melanogaster 21-24 19270172-0 2009 The co-regulator dNAB interacts with Brinker to eliminate cells with reduced Dpp signaling. dipalmitoylphosphatidylserine 77-80 nab Drosophila melanogaster 17-21 19270172-0 2009 The co-regulator dNAB interacts with Brinker to eliminate cells with reduced Dpp signaling. dipalmitoylphosphatidylserine 77-80 brinker Drosophila melanogaster 37-44 19270172-4 2009 Much of the regulation of transcriptional output by Dpp is mediated through repression of the transcriptional repressor Brinker (Brk), and thus through the activation of target genes. dipalmitoylphosphatidylserine 52-55 brinker Drosophila melanogaster 120-127 19270172-4 2009 Much of the regulation of transcriptional output by Dpp is mediated through repression of the transcriptional repressor Brinker (Brk), and thus through the activation of target genes. dipalmitoylphosphatidylserine 52-55 brinker Drosophila melanogaster 129-132 19270172-6 2009 At the molecular level, reduced Dpp signaling results in Brk upregulation that triggers apoptosis through activation of the JNK pathway. dipalmitoylphosphatidylserine 32-35 brinker Drosophila melanogaster 57-60 19270172-6 2009 At the molecular level, reduced Dpp signaling results in Brk upregulation that triggers apoptosis through activation of the JNK pathway. dipalmitoylphosphatidylserine 32-35 basket Drosophila melanogaster 124-127 19270172-7 2009 Here we show that the transcriptional co-regulator dNAB is a Dpp target in the developing wing that interacts with Brk to eliminate cells with reduced Dpp signaling through the JNK pathway. dipalmitoylphosphatidylserine 61-64 nab Drosophila melanogaster 51-55 19270172-7 2009 Here we show that the transcriptional co-regulator dNAB is a Dpp target in the developing wing that interacts with Brk to eliminate cells with reduced Dpp signaling through the JNK pathway. dipalmitoylphosphatidylserine 61-64 brinker Drosophila melanogaster 115-118 19270172-7 2009 Here we show that the transcriptional co-regulator dNAB is a Dpp target in the developing wing that interacts with Brk to eliminate cells with reduced Dpp signaling through the JNK pathway. dipalmitoylphosphatidylserine 61-64 basket Drosophila melanogaster 177-180 19270172-7 2009 Here we show that the transcriptional co-regulator dNAB is a Dpp target in the developing wing that interacts with Brk to eliminate cells with reduced Dpp signaling through the JNK pathway. dipalmitoylphosphatidylserine 151-154 nab Drosophila melanogaster 51-55 19270172-7 2009 Here we show that the transcriptional co-regulator dNAB is a Dpp target in the developing wing that interacts with Brk to eliminate cells with reduced Dpp signaling through the JNK pathway. dipalmitoylphosphatidylserine 151-154 brinker Drosophila melanogaster 115-118 19270172-7 2009 Here we show that the transcriptional co-regulator dNAB is a Dpp target in the developing wing that interacts with Brk to eliminate cells with reduced Dpp signaling through the JNK pathway. dipalmitoylphosphatidylserine 151-154 basket Drosophila melanogaster 177-180 19270172-8 2009 We further show that both dNAB and Brk are required for cell elimination induced by differential dMyc expression, a process that depends on reduced Dpp transduction in outcompeted cells. dipalmitoylphosphatidylserine 148-151 nab Drosophila melanogaster 26-30 19270172-8 2009 We further show that both dNAB and Brk are required for cell elimination induced by differential dMyc expression, a process that depends on reduced Dpp transduction in outcompeted cells. dipalmitoylphosphatidylserine 148-151 brinker Drosophila melanogaster 35-38 19270172-8 2009 We further show that both dNAB and Brk are required for cell elimination induced by differential dMyc expression, a process that depends on reduced Dpp transduction in outcompeted cells. dipalmitoylphosphatidylserine 148-151 Myc Drosophila melanogaster 97-101 19270172-9 2009 We propose a novel mechanism whereby the morphogen Dpp regulates the responsiveness to its own survival signal by inversely controlling the expression of a repressor, Brk, and its co-repressor, dNAB. dipalmitoylphosphatidylserine 51-54 brinker Drosophila melanogaster 167-170 19270172-9 2009 We propose a novel mechanism whereby the morphogen Dpp regulates the responsiveness to its own survival signal by inversely controlling the expression of a repressor, Brk, and its co-repressor, dNAB. dipalmitoylphosphatidylserine 51-54 nab Drosophila melanogaster 194-198 19028484-6 2009 We show further that Tin repression and pericardial restriction in the dorsal mesoderm facilitated by Lmd is instructed by a late Decapentaplegic (Dpp) signal that is abolished in embryos carrying the disk region mutation dpp(d6). dipalmitoylphosphatidylserine 222-225 lame duck Drosophila melanogaster 102-105 18791638-8 2008 Further characterization of two additional members of the BMP signaling pathway, Mothers against dpp (Mad) and Daughters against dpp (Dad), also modify the Smn NMJ phenotype. dipalmitoylphosphatidylserine 97-100 survival motor neuron Drosophila melanogaster 156-159 19536201-5 2009 The joint activation of the EGFR and DPP signaling systems is ensured by a positive feedback loop, in which the two pathways stimulate each other at the level of ligand production. dipalmitoylphosphatidylserine 37-40 Epidermal growth factor receptor Drosophila melanogaster 28-32 18779662-0 2008 Dpp represses eagle expression at short-range, but can repress its expression at a long-range via EGFR signal repression. dipalmitoylphosphatidylserine 0-3 epidermal growth factor receptor Homo sapiens 98-102 18779662-7 2008 However, Dpp produced from en-GAL4/UAS-dpp or wg-GAL4/UAS-dpp primarily acted at short-range. dipalmitoylphosphatidylserine 9-12 galectin 4 Homo sapiens 30-34 18779662-7 2008 However, Dpp produced from en-GAL4/UAS-dpp or wg-GAL4/UAS-dpp primarily acted at short-range. dipalmitoylphosphatidylserine 9-12 galectin 4 Homo sapiens 49-53 19086158-0 2008 The PT1-Ca2+ Gla domain binds to a membrane through two dipalmitoylphosphatidylserines. dipalmitoylphosphatidylserine 56-86 carbonic anhydrase 2 Homo sapiens 8-11 19086158-4 2008 To investigate the binding of the Gla domain of prothrombin fragment 1 (PT1) to anionic lipids in the presence of Ca2+, we have conducted MD simulations of the protein with one and two dipalmitoylphosphatidylserines (DPPS) in a dipalmitoylphosphatidylcholine (DPPC) bilayer membrane. dipalmitoylphosphatidylserine 185-215 coagulation factor II, thrombin Homo sapiens 48-59 19086158-4 2008 To investigate the binding of the Gla domain of prothrombin fragment 1 (PT1) to anionic lipids in the presence of Ca2+, we have conducted MD simulations of the protein with one and two dipalmitoylphosphatidylserines (DPPS) in a dipalmitoylphosphatidylcholine (DPPC) bilayer membrane. dipalmitoylphosphatidylserine 217-221 coagulation factor II, thrombin Homo sapiens 48-59 19086158-14 2008 On the basis of free energy simulations, we estimate the energy of binding of the PT1-Ca2+ complex to a single DPPS to be around -11.5 kcal/mol. dipalmitoylphosphatidylserine 111-115 carbonic anhydrase 2 Homo sapiens 86-89 18815369-4 2008 Hyperactivation of Zfh1, Srp, and Ush in dpp mutants leads to hyperplasia of plasmatocytes. dipalmitoylphosphatidylserine 41-44 Zn finger homeodomain 1 Drosophila melanogaster 19-23 18815369-4 2008 Hyperactivation of Zfh1, Srp, and Ush in dpp mutants leads to hyperplasia of plasmatocytes. dipalmitoylphosphatidylserine 41-44 serpent Drosophila melanogaster 25-28 18815369-4 2008 Hyperactivation of Zfh1, Srp, and Ush in dpp mutants leads to hyperplasia of plasmatocytes. dipalmitoylphosphatidylserine 41-44 u-shaped Drosophila melanogaster 34-37 18779662-8 2008 This result demonstrated that this discrepancy seems to be due to the repression of Dpp to EGFR signaling in sim;;dpp embryos. dipalmitoylphosphatidylserine 84-87 epidermal growth factor receptor Homo sapiens 91-95 18779662-9 2008 Taken together, these results suggest that Dpp signaling works at short-range, but can function indirectly at long-range by way of repression of EGFR signaling during embryonic neurogenesis. dipalmitoylphosphatidylserine 43-46 epidermal growth factor receptor Homo sapiens 145-149 18621014-2 2008 In particular, the interaction of hIAPP and its rat isoform (rIAPP) with zwitterionic dipalmitoyl-phosphatidylcholine (DPPC), negatively charged dipalmitoyl-phosphatidylserine (DPPS) vesicles and with a 3:1 mixtures of them, has been studied in the presence of Ca(2+) ions. dipalmitoylphosphatidylserine 145-175 islet amyloid polypeptide Homo sapiens 34-39 18621014-2 2008 In particular, the interaction of hIAPP and its rat isoform (rIAPP) with zwitterionic dipalmitoyl-phosphatidylcholine (DPPC), negatively charged dipalmitoyl-phosphatidylserine (DPPS) vesicles and with a 3:1 mixtures of them, has been studied in the presence of Ca(2+) ions. dipalmitoylphosphatidylserine 145-175 islet amyloid polypeptide Rattus norvegicus 61-66 18621014-2 2008 In particular, the interaction of hIAPP and its rat isoform (rIAPP) with zwitterionic dipalmitoyl-phosphatidylcholine (DPPC), negatively charged dipalmitoyl-phosphatidylserine (DPPS) vesicles and with a 3:1 mixtures of them, has been studied in the presence of Ca(2+) ions. dipalmitoylphosphatidylserine 177-181 islet amyloid polypeptide Homo sapiens 34-39 18621014-2 2008 In particular, the interaction of hIAPP and its rat isoform (rIAPP) with zwitterionic dipalmitoyl-phosphatidylcholine (DPPC), negatively charged dipalmitoyl-phosphatidylserine (DPPS) vesicles and with a 3:1 mixtures of them, has been studied in the presence of Ca(2+) ions. dipalmitoylphosphatidylserine 177-181 islet amyloid polypeptide Rattus norvegicus 61-66 18621014-4 2008 Conversely, the presence of Ca(2+) ions is necessary to activate a preferential interaction of hIAPP with the hydrophobic core of DPPS membranes. dipalmitoylphosphatidylserine 130-134 islet amyloid polypeptide Homo sapiens 95-100 18791638-8 2008 Further characterization of two additional members of the BMP signaling pathway, Mothers against dpp (Mad) and Daughters against dpp (Dad), also modify the Smn NMJ phenotype. dipalmitoylphosphatidylserine 129-132 survival motor neuron Drosophila melanogaster 156-159 18171682-0 2008 Jak/Stat signalling in niche support cells regulates dpp transcription to control germline stem cell maintenance in the Drosophila ovary. dipalmitoylphosphatidylserine 53-56 hopscotch Drosophila melanogaster 0-3 18694569-2 2008 We show that the Dpp morphogen gradient in the Drosophila wing influences growth by modulating the activity of the Fat signaling pathway. dipalmitoylphosphatidylserine 17-20 fat Drosophila melanogaster 115-118 18694569-3 2008 Dpp signaling regulates the expression and localization of Fat pathway components, and Fat signaling through Dachs is required for the effect of the Dpp gradient on cell proliferation. dipalmitoylphosphatidylserine 0-3 fat Drosophila melanogaster 59-62 18694569-3 2008 Dpp signaling regulates the expression and localization of Fat pathway components, and Fat signaling through Dachs is required for the effect of the Dpp gradient on cell proliferation. dipalmitoylphosphatidylserine 149-152 fat Drosophila melanogaster 87-90 18539010-0 2008 Hedgehog and Dpp signaling induce cadherin Cad86C expression in the morphogenetic furrow during Drosophila eye development. dipalmitoylphosphatidylserine 13-16 Cadherin 86C Drosophila melanogaster 34-49 18539010-0 2008 Hedgehog and Dpp signaling induce cadherin Cad86C expression in the morphogenetic furrow during Drosophila eye development. dipalmitoylphosphatidylserine 13-16 furrow Drosophila melanogaster 82-88 18539010-6 2008 Ectopic activation of either the Hedgehog or Dpp signal transduction pathway results in elevated Cad86C expression. dipalmitoylphosphatidylserine 45-48 Cadherin 86C Drosophila melanogaster 97-103 18539010-7 2008 Conversely, simultaneous loss of both Hedgehog and Dpp signal transduction leads to decreased Cad86C expression. dipalmitoylphosphatidylserine 51-54 Cadherin 86C Drosophila melanogaster 94-100 18539010-9 2008 We conclude that Hedgehog and Dpp signaling promote the shortening of cells within the morphogenetic furrow. dipalmitoylphosphatidylserine 30-33 furrow Drosophila melanogaster 101-107 18539010-10 2008 Induction of Cad86C expression might be one mechanism through which Hedgehog and Dpp promote these cell shape changes. dipalmitoylphosphatidylserine 81-84 Cadherin 86C Drosophila melanogaster 13-19 18571155-5 2008 We show that zfh2 expression is delimited distally by Vg, Nub and Dpp signalling, and proximally by Tsh and Dpp. dipalmitoylphosphatidylserine 66-69 Zn finger homeodomain 2 Drosophila melanogaster 13-17 18571155-5 2008 We show that zfh2 expression is delimited distally by Vg, Nub and Dpp signalling, and proximally by Tsh and Dpp. dipalmitoylphosphatidylserine 108-111 Zn finger homeodomain 2 Drosophila melanogaster 13-17 18171682-0 2008 Jak/Stat signalling in niche support cells regulates dpp transcription to control germline stem cell maintenance in the Drosophila ovary. dipalmitoylphosphatidylserine 53-56 Signal-transducer and activator of transcription protein at 92E Drosophila melanogaster 4-8 18171682-5 2008 We further show that ectopic Jak/Stat signalling in support cells augments dpp mRNA levels and increases the range of Dpp signalling, a Bmp2 orthologue known to act as a niche extrinsic factor required for female germline stem cell survival and division. dipalmitoylphosphatidylserine 75-78 hopscotch Drosophila melanogaster 29-32 18171682-5 2008 We further show that ectopic Jak/Stat signalling in support cells augments dpp mRNA levels and increases the range of Dpp signalling, a Bmp2 orthologue known to act as a niche extrinsic factor required for female germline stem cell survival and division. dipalmitoylphosphatidylserine 75-78 Signal-transducer and activator of transcription protein at 92E Drosophila melanogaster 33-37 18171682-5 2008 We further show that ectopic Jak/Stat signalling in support cells augments dpp mRNA levels and increases the range of Dpp signalling, a Bmp2 orthologue known to act as a niche extrinsic factor required for female germline stem cell survival and division. dipalmitoylphosphatidylserine 118-121 hopscotch Drosophila melanogaster 29-32 18171682-5 2008 We further show that ectopic Jak/Stat signalling in support cells augments dpp mRNA levels and increases the range of Dpp signalling, a Bmp2 orthologue known to act as a niche extrinsic factor required for female germline stem cell survival and division. dipalmitoylphosphatidylserine 118-121 Signal-transducer and activator of transcription protein at 92E Drosophila melanogaster 33-37 18171682-6 2008 Our results provide strong evidence for a model in which Jak/Stat signalling in somatic support cells regulates dpp transcription to define niche size and to maintain the adjacent germline stem cells in an undifferentiated state. dipalmitoylphosphatidylserine 112-115 hopscotch Drosophila melanogaster 57-60 18171682-6 2008 Our results provide strong evidence for a model in which Jak/Stat signalling in somatic support cells regulates dpp transcription to define niche size and to maintain the adjacent germline stem cells in an undifferentiated state. dipalmitoylphosphatidylserine 112-115 Signal-transducer and activator of transcription protein at 92E Drosophila melanogaster 61-65 17604656-4 2007 The aim of this study was to determine whether the modulation of the response of articular chondrocytes to TGF-beta by IL-1beta or TNF-alpha signaling pathways occurs through regulation of activity and availability of mothers against DPP (Drosophila) human homologue (Smad) proteins. dipalmitoylphosphatidylserine 234-237 decapentaplegic Drosophila melanogaster 107-115 18077592-5 2008 We show that the resulting changes in the Br pattern affect the expression of Dpp receptor thickveins (tkv), which is essential for Dpp signaling. dipalmitoylphosphatidylserine 78-81 thickveins Drosophila melanogaster 103-106 18077592-6 2008 By controlling tkv, Br controls Dpp signaling in late stages of oogenesis and, as a result, regulates its own repression in a negative-feedback loop. dipalmitoylphosphatidylserine 32-35 thickveins Drosophila melanogaster 15-18 18068697-0 2008 A combinatorial enhancer recognized by Mad, TCF and Brinker first activates then represses dpp expression in the posterior spiracles of Drosophila. dipalmitoylphosphatidylserine 91-94 pangolin Drosophila melanogaster 44-47 18068697-6 2008 Together with gene expression data from these mutants and from brk mutants, our results suggest that there are two rounds of Dpp signaling in posterior spiracle development. dipalmitoylphosphatidylserine 125-128 brinker Drosophila melanogaster 63-66 17604656-4 2007 The aim of this study was to determine whether the modulation of the response of articular chondrocytes to TGF-beta by IL-1beta or TNF-alpha signaling pathways occurs through regulation of activity and availability of mothers against DPP (Drosophila) human homologue (Smad) proteins. dipalmitoylphosphatidylserine 234-237 interleukin 1 beta Homo sapiens 119-127 17604656-4 2007 The aim of this study was to determine whether the modulation of the response of articular chondrocytes to TGF-beta by IL-1beta or TNF-alpha signaling pathways occurs through regulation of activity and availability of mothers against DPP (Drosophila) human homologue (Smad) proteins. dipalmitoylphosphatidylserine 234-237 eiger Drosophila melanogaster 131-140 17434471-8 2007 Mutations in either the Smad2-3 or Smad4 putative binding sites of dSnoN prevent the antagonism of dSnoN towards Dpp signaling, although homozygous flies for these mutations or for a genetic deficiency of the locus are viable and have wings of normal size and pattern. dipalmitoylphosphatidylserine 113-116 Smad on X Drosophila melanogaster 24-31 17981140-5 2007 In the MF, Hedgehog (Hh) signaling is required to promote cell constriction downstream of cubitus interruptus (ci), and, in this context, Ci155 functions redundantly with mad, the main effector of dpp/BMP signaling. dipalmitoylphosphatidylserine 197-200 cubitus interruptus Drosophila melanogaster 138-143 17507396-9 2007 One of these inhibitors is Drosophila sno (dSno), a homolog of the Ski/Sno family of vertebrate proto-oncogenes, which synergizes with daughters against dpp and brinker to set the posterior and lateral limits of the region, giving rise to dorsal follicle cells. dipalmitoylphosphatidylserine 153-156 strawberry notch Drosophila melanogaster 38-41 17434471-8 2007 Mutations in either the Smad2-3 or Smad4 putative binding sites of dSnoN prevent the antagonism of dSnoN towards Dpp signaling, although homozygous flies for these mutations or for a genetic deficiency of the locus are viable and have wings of normal size and pattern. dipalmitoylphosphatidylserine 113-116 Medea Drosophila melanogaster 35-40 17434471-8 2007 Mutations in either the Smad2-3 or Smad4 putative binding sites of dSnoN prevent the antagonism of dSnoN towards Dpp signaling, although homozygous flies for these mutations or for a genetic deficiency of the locus are viable and have wings of normal size and pattern. dipalmitoylphosphatidylserine 113-116 Sno oncogene Drosophila melanogaster 67-72 17507396-9 2007 One of these inhibitors is Drosophila sno (dSno), a homolog of the Ski/Sno family of vertebrate proto-oncogenes, which synergizes with daughters against dpp and brinker to set the posterior and lateral limits of the region, giving rise to dorsal follicle cells. dipalmitoylphosphatidylserine 153-156 Si Drosophila melanogaster 67-70 17507396-9 2007 One of these inhibitors is Drosophila sno (dSno), a homolog of the Ski/Sno family of vertebrate proto-oncogenes, which synergizes with daughters against dpp and brinker to set the posterior and lateral limits of the region, giving rise to dorsal follicle cells. dipalmitoylphosphatidylserine 153-156 strawberry notch Drosophila melanogaster 44-47 17434471-8 2007 Mutations in either the Smad2-3 or Smad4 putative binding sites of dSnoN prevent the antagonism of dSnoN towards Dpp signaling, although homozygous flies for these mutations or for a genetic deficiency of the locus are viable and have wings of normal size and pattern. dipalmitoylphosphatidylserine 113-116 Sno oncogene Drosophila melanogaster 99-104 17277191-5 2007 The free energy of association between dipalmitoylphosphatidylserines in the environment of dipalmitoylphosphatidylcholines has been calculated by using a novel approach to the dual topology technique of the PS-PC hybrid. dipalmitoylphosphatidylserine 39-69 surfactant protein C Homo sapiens 208-213 17045257-4 2007 The Decapentaplegic signaling is down-regulated in haltere discs due to a combination of reduced levels of the Dpp, its trapping at the A/P boundary by increased levels of its receptor Thick-vein and its inability to diffuse in the absence of Dally. dipalmitoylphosphatidylserine 111-114 thv Drosophila melanogaster 185-195 17409113-8 2007 Whereas the Iro-C genes are activated in the notum anlage by EGFR signalling, tup is positively regulated by Dpp signalling. dipalmitoylphosphatidylserine 109-112 tailup Drosophila melanogaster 78-81 17409113-9 2007 Our data support a model in which the EGFR and Dpp signalling pathways, with their respective downstream Iro-C and tup genes, converge and cooperate to commit cells to the notum developmental fate. dipalmitoylphosphatidylserine 47-50 tailup Drosophila melanogaster 115-118 17333257-2 2007 Its expression is dependent on the Jun N-terminal kinase (JNK) cascade, and it functions downstream of Jun regulating dpp expression in the leading edge cells. dipalmitoylphosphatidylserine 118-121 basket Drosophila melanogaster 35-56 17333257-2 2007 Its expression is dependent on the Jun N-terminal kinase (JNK) cascade, and it functions downstream of Jun regulating dpp expression in the leading edge cells. dipalmitoylphosphatidylserine 118-121 basket Drosophila melanogaster 58-61 17335573-7 2007 Additionally, inhibition of Cyclin A by Roughex is essential, and this regulation is independent of Dpp and Hh. dipalmitoylphosphatidylserine 100-103 Cyclin A Drosophila melanogaster 28-36 17045257-4 2007 The Decapentaplegic signaling is down-regulated in haltere discs due to a combination of reduced levels of the Dpp, its trapping at the A/P boundary by increased levels of its receptor Thick-vein and its inability to diffuse in the absence of Dally. dipalmitoylphosphatidylserine 111-114 division abnormally delayed Drosophila melanogaster 243-248 17008069-0 2006 Drosophila alpha-actinin in ovarian follicle cells is regulated by EGFR and Dpp signalling and required for cytoskeletal remodelling. dipalmitoylphosphatidylserine 76-79 alpha actinin Drosophila melanogaster 11-24 17110495-5 2007 Most mutations that rescue cell competition elevated Dpp-signaling activity, and the Dsmurf mutation that elevates Dpp signaling was also hyperplastic and rescued. dipalmitoylphosphatidylserine 115-118 SMAD specific E3 ubiquitin protein ligase Drosophila melanogaster 85-91 17206277-0 2007 Wingless directly represses DPP morphogen expression via an armadillo/TCF/Brinker complex. dipalmitoylphosphatidylserine 28-31 pangolin Drosophila melanogaster 70-73 17206277-5 2007 Repression of dpp requires a tri-partite complex of the WG mediators armadillo (ARM) and dTCF, and the co-repressor Brinker, (BRK), wherein ARM.dTCF and BRK bind to independent sites within the dpp locus. dipalmitoylphosphatidylserine 14-17 pangolin Drosophila melanogaster 89-93 17206277-5 2007 Repression of dpp requires a tri-partite complex of the WG mediators armadillo (ARM) and dTCF, and the co-repressor Brinker, (BRK), wherein ARM.dTCF and BRK bind to independent sites within the dpp locus. dipalmitoylphosphatidylserine 14-17 brinker Drosophila melanogaster 126-129 17206277-5 2007 Repression of dpp requires a tri-partite complex of the WG mediators armadillo (ARM) and dTCF, and the co-repressor Brinker, (BRK), wherein ARM.dTCF and BRK bind to independent sites within the dpp locus. dipalmitoylphosphatidylserine 14-17 pangolin Drosophila melanogaster 144-148 17206277-5 2007 Repression of dpp requires a tri-partite complex of the WG mediators armadillo (ARM) and dTCF, and the co-repressor Brinker, (BRK), wherein ARM.dTCF and BRK bind to independent sites within the dpp locus. dipalmitoylphosphatidylserine 14-17 brinker Drosophila melanogaster 153-156 17206277-5 2007 Repression of dpp requires a tri-partite complex of the WG mediators armadillo (ARM) and dTCF, and the co-repressor Brinker, (BRK), wherein ARM.dTCF and BRK bind to independent sites within the dpp locus. dipalmitoylphosphatidylserine 194-197 brinker Drosophila melanogaster 126-129 17206277-5 2007 Repression of dpp requires a tri-partite complex of the WG mediators armadillo (ARM) and dTCF, and the co-repressor Brinker, (BRK), wherein ARM.dTCF and BRK bind to independent sites within the dpp locus. dipalmitoylphosphatidylserine 194-197 pangolin Drosophila melanogaster 144-148 17206277-5 2007 Repression of dpp requires a tri-partite complex of the WG mediators armadillo (ARM) and dTCF, and the co-repressor Brinker, (BRK), wherein ARM.dTCF and BRK bind to independent sites within the dpp locus. dipalmitoylphosphatidylserine 194-197 brinker Drosophila melanogaster 153-156 17173387-1 2006 A new tetrametallic supramolecular complex, [{(bpy)2Ru(dpp)}2Ru(dpp)PtCl2](PF6)6 (bpy = 2,2"-bipyridine, dpp = 2,3-bis(2-pyridyl)pyrazine), has been prepared and characterized. dipalmitoylphosphatidylserine 55-58 sperm associated antigen 17 Homo sapiens 75-80 17092951-0 2006 Threshold response of C15 to the Dpp gradient in Drosophila is established by the cumulative effect of Smad and Zen activators and negative cues. dipalmitoylphosphatidylserine 33-36 C15 Drosophila melanogaster 22-25 17092951-0 2006 Threshold response of C15 to the Dpp gradient in Drosophila is established by the cumulative effect of Smad and Zen activators and negative cues. dipalmitoylphosphatidylserine 33-36 Mothers against dpp Drosophila melanogaster 103-107 17092951-4 2006 We analyzed the regulation of the C15 gene, which can be activated in cells containing intermediate levels of Dpp. dipalmitoylphosphatidylserine 110-113 C15 Drosophila melanogaster 34-37 17092951-5 2006 We show that C15 expression requires both dpp and zen, thus forming a genetic feed-forward loop. dipalmitoylphosphatidylserine 42-45 C15 Drosophila melanogaster 13-16 17092951-8 2006 Thus, the combinatorial action of Smad and Zen activators bound to a number of adjacent sites, and competing negative cues allows for proper gene response to lower than peak levels of the Dpp morphogen. dipalmitoylphosphatidylserine 188-191 Mothers against dpp Drosophila melanogaster 34-38 16924657-4 2006 In postnatal rat testes, AEP1 mRNA became detectable from postnatal 25 dpp (round spermatids) and onwards. dipalmitoylphosphatidylserine 71-74 SPATA31 subfamily A member 5 Rattus norvegicus 25-29 17034148-3 2006 Further modification led to an extremely potent (Ki(DPP)(-)(IV) = 1.0 nM) and selective (Ki(DPP8) > 30 microM; Ki(DPP9) > 30 microM) clinical candidate, ABT-279, that is orally available, efficacious, and remarkably safe in preclinical safety studies. dipalmitoylphosphatidylserine 52-55 dipeptidyl peptidase 8 Homo sapiens 92-96 17034148-3 2006 Further modification led to an extremely potent (Ki(DPP)(-)(IV) = 1.0 nM) and selective (Ki(DPP8) > 30 microM; Ki(DPP9) > 30 microM) clinical candidate, ABT-279, that is orally available, efficacious, and remarkably safe in preclinical safety studies. dipalmitoylphosphatidylserine 52-55 dipeptidyl peptidase 9 Homo sapiens 117-121 16828038-9 2006 Accordingly, it is proposed, although not proved, that the more the wing cells express d-Myc and amplify their protein synthesis apparatus, the more they bind, internalize, and transduce the vital and limiting growth factor Dpp, which in turn is presumed to increase d-Myc protein level. dipalmitoylphosphatidylserine 224-227 Myc Drosophila melanogaster 87-92 16643887-0 2006 Dpp and Gbb exhibit different effective ranges in the establishment of the BMP activity gradient critical for Drosophila wing patterning. dipalmitoylphosphatidylserine 0-3 glass bottom boat Drosophila melanogaster 75-78 16643887-3 2006 Our data indicate that the relative contributions of two BMP ligands, Gbb and Dpp, to patterning the wing imaginal disc along its A/P axis, change as a function of distance from the ligand source. dipalmitoylphosphatidylserine 78-81 glass bottom boat Drosophila melanogaster 57-60 16828077-3 2006 The conserved antagonism between two secreted factors, BMP2/4 (Dpp in Drosophila) and its antagonist Chordin (Short gastrulation in Drosophila) is a crucial component in the establishment of the dorsoventral body axis of Bilateria and could therefore provide important insight into the evolutionary origin of bilaterian axes. dipalmitoylphosphatidylserine 63-66 short gastrulation Drosophila melanogaster 101-108 16781701-5 2006 We find that metalloproteases encoded by tolloid (tld) and tolkin (tok), which cleave Sog, are expressed by follicle cells and are required to generate DV asymmetry in the Dpp signal. dipalmitoylphosphatidylserine 172-175 short gastrulation Drosophila melanogaster 86-89 16880529-2 2006 In Drosophila, Cubitus interruptus (Ci), which mediates hedgehog signaling, regulates gene expression of dpp, the ortholog of mammalian BMP-2. dipalmitoylphosphatidylserine 105-108 cubitus interruptus Drosophila melanogaster 15-34 16880529-2 2006 In Drosophila, Cubitus interruptus (Ci), which mediates hedgehog signaling, regulates gene expression of dpp, the ortholog of mammalian BMP-2. dipalmitoylphosphatidylserine 105-108 cubitus interruptus Drosophila melanogaster 36-38 16880529-2 2006 In Drosophila, Cubitus interruptus (Ci), which mediates hedgehog signaling, regulates gene expression of dpp, the ortholog of mammalian BMP-2. dipalmitoylphosphatidylserine 105-108 bone morphogenetic protein 2 Homo sapiens 136-141 16720876-8 2006 Furthermore, we showed that embryos depleted for a spider homologue of dpp failed to break the radial symmetry, displaying evenly high levels of sog expression except in the posterior terminal area. dipalmitoylphosphatidylserine 71-74 short gastrulation Drosophila melanogaster 145-148 16828038-9 2006 Accordingly, it is proposed, although not proved, that the more the wing cells express d-Myc and amplify their protein synthesis apparatus, the more they bind, internalize, and transduce the vital and limiting growth factor Dpp, which in turn is presumed to increase d-Myc protein level. dipalmitoylphosphatidylserine 224-227 Myc Drosophila melanogaster 267-272 16506749-2 2006 The reaction of PCl3 with SnCl2 in THF solution, followed by treatment with dpp-BIAN (dpp = 2,6-i-Pr2C6H3), affords the phosphenium complex [(dpp-BIAN)P][SnCl5.THF]. dipalmitoylphosphatidylserine 76-79 PHD finger protein 19 Homo sapiens 16-20 16707253-2 2006 Through clonal analysis, we found that brinker (brk), a repressor of Dpp signaling, plays an important role in the Drosophila ovary, where its function is essential for dorsal appendage formation. dipalmitoylphosphatidylserine 69-72 brinker Drosophila melanogaster 39-46 16707253-2 2006 Through clonal analysis, we found that brinker (brk), a repressor of Dpp signaling, plays an important role in the Drosophila ovary, where its function is essential for dorsal appendage formation. dipalmitoylphosphatidylserine 69-72 brinker Drosophila melanogaster 48-51 16254193-10 2006 CONCLUSIONS: DPP IV cleaves BNP (1-32) with an efficiency higher than or comparable to several known in vivo substrates of the enzyme. dipalmitoylphosphatidylserine 13-16 natriuretic peptide B Homo sapiens 28-31 16254193-2 2006 The objectives of this study were to investigate (a) whether BNP and other natriuretic peptides are truncated by dipeptidyl-peptidase IV (DPP IV/CD26; EC 3.4.14.5) and (b) whether this truncation affects the susceptibility to cleavage by neutral endopeptidase (NEP; EC 3.4.24.11). dipalmitoylphosphatidylserine 138-141 natriuretic peptide B Homo sapiens 61-64 15972466-5 2005 Here we report the unexpected identification of one of the Su(dpp) mutations as an allele of the eukaryotic translation initiation factor 4A (eIF4A). dipalmitoylphosphatidylserine 62-65 eukaryotic translation initiation factor 4A Drosophila melanogaster 97-140 16254193-2 2006 The objectives of this study were to investigate (a) whether BNP and other natriuretic peptides are truncated by dipeptidyl-peptidase IV (DPP IV/CD26; EC 3.4.14.5) and (b) whether this truncation affects the susceptibility to cleavage by neutral endopeptidase (NEP; EC 3.4.24.11). dipalmitoylphosphatidylserine 138-141 dipeptidyl peptidase 4 Homo sapiens 113-136 16254193-6 2006 RESULTS: BNP (1-32) was cleaved by purified DPP IV with a specificity constant of 0.37 x 10(6) L.mol(-1).s(-1). dipalmitoylphosphatidylserine 44-47 natriuretic peptide B Homo sapiens 9-12 16254193-7 2006 The DPP IV activity in EDTA-plasma was able to truncate BNP (1-32) ex vivo. dipalmitoylphosphatidylserine 4-7 natriuretic peptide B Homo sapiens 56-59 16280348-3 2005 pelota (pelo), which has been previously shown to be required for Drosophila male meiosis, was identified in our genetic screen as a dominant suppressor of the dpp overexpression-induced GSC tumor phenotype. dipalmitoylphosphatidylserine 160-163 pelota Drosophila melanogaster 0-6 16280348-3 2005 pelota (pelo), which has been previously shown to be required for Drosophila male meiosis, was identified in our genetic screen as a dominant suppressor of the dpp overexpression-induced GSC tumor phenotype. dipalmitoylphosphatidylserine 160-163 pelota Drosophila melanogaster 0-4 15972466-5 2005 Here we report the unexpected identification of one of the Su(dpp) mutations as an allele of the eukaryotic translation initiation factor 4A (eIF4A). dipalmitoylphosphatidylserine 62-65 eukaryotic translation initiation factor 4A Drosophila melanogaster 142-147 15922573-10 2005 We propose that one of the major functions of mid and H15 during cardioblast development is the re-activation of tin expression at a stage when the induction of tin by Dpp in the dorsal mesoderm has ceased. dipalmitoylphosphatidylserine 168-171 midline Drosophila melanogaster 46-49 16198331-8 2005 A combination of molecular and genetic analyses demonstrates that cbt expression is dependent on the JNK cascade during dorsal closure, and it functions downstream of Jun regulating dpp expression in the leading edge cells. dipalmitoylphosphatidylserine 182-185 cabut Drosophila melanogaster 66-69 16176948-8 2005 Its expression depends on DPP; gcm is reduced or absent in dpp mutants or Medea clones, and ectopic activation of DPP signaling induces ectopic expression of gcm and REPO. dipalmitoylphosphatidylserine 26-29 reversed polarity Drosophila melanogaster 166-170 16176948-8 2005 Its expression depends on DPP; gcm is reduced or absent in dpp mutants or Medea clones, and ectopic activation of DPP signaling induces ectopic expression of gcm and REPO. dipalmitoylphosphatidylserine 114-117 reversed polarity Drosophila melanogaster 166-170 15922573-10 2005 We propose that one of the major functions of mid and H15 during cardioblast development is the re-activation of tin expression at a stage when the induction of tin by Dpp in the dorsal mesoderm has ceased. dipalmitoylphosphatidylserine 168-171 H15 Drosophila melanogaster 54-57 15922573-10 2005 We propose that one of the major functions of mid and H15 during cardioblast development is the re-activation of tin expression at a stage when the induction of tin by Dpp in the dorsal mesoderm has ceased. dipalmitoylphosphatidylserine 168-171 tinman Drosophila melanogaster 113-116 15922573-10 2005 We propose that one of the major functions of mid and H15 during cardioblast development is the re-activation of tin expression at a stage when the induction of tin by Dpp in the dorsal mesoderm has ceased. dipalmitoylphosphatidylserine 168-171 tinman Drosophila melanogaster 161-164 15857915-9 2005 Mild overactivation of the Dpp pathway caused similar phenotypes that could be antagonized by simultaneous overexpression of Slmb, suggesting that Slmb might normally downregulate the Dpp pathway in follicle cells. dipalmitoylphosphatidylserine 27-30 supernumerary limbs Drosophila melanogaster 147-151 16124698-15 2005 Regarding cows with a severe endometritis (E2 and E3) the percentage of pregnant cows 200 dpp was higher in the group treated early (E2: 78.4%; E3: 80.0%) than in the group with the late initiation of the treatment (E2: 68.6%; E3: 54.5%, p < 0.05). dipalmitoylphosphatidylserine 90-93 dihydrolipoamide branched chain transacylase E2 Bos taurus 43-52 15857915-9 2005 Mild overactivation of the Dpp pathway caused similar phenotypes that could be antagonized by simultaneous overexpression of Slmb, suggesting that Slmb might normally downregulate the Dpp pathway in follicle cells. dipalmitoylphosphatidylserine 184-187 supernumerary limbs Drosophila melanogaster 147-151 15857915-10 2005 Indeed, ectopic expression of a dad-LacZ enhancer trap revealed that the Dpp pathway was upregulated in slmb somatic clones and, consistent with this, ectopic accumulation of the co-Smad protein, Medea, was recorded. dipalmitoylphosphatidylserine 73-76 supernumerary limbs Drosophila melanogaster 104-108 15634705-6 2005 The regulation of hth/exd expression is achieved by the combined repressing functions of the Pax gene eyegone (eyg) and of the Dpp pathway. dipalmitoylphosphatidylserine 127-130 homothorax Drosophila melanogaster 18-21 15916937-2 2005 Two recent studies finally reveal Dpp distribution, providing further insights into the mechanism of BMP gradient formation. dipalmitoylphosphatidylserine 34-37 decapentaplegic Drosophila melanogaster 101-104 15634705-6 2005 The regulation of hth/exd expression is achieved by the combined repressing functions of the Pax gene eyegone (eyg) and of the Dpp pathway. dipalmitoylphosphatidylserine 127-130 extradenticle Drosophila melanogaster 22-25 15634705-7 2005 hth/exd is repressed in the body regions where eyg is active and that also contain high levels of Dpp activity. dipalmitoylphosphatidylserine 98-101 homothorax Drosophila melanogaster 0-3 15634705-7 2005 hth/exd is repressed in the body regions where eyg is active and that also contain high levels of Dpp activity. dipalmitoylphosphatidylserine 98-101 extradenticle Drosophila melanogaster 4-7 15280207-2 2004 Although Drosophila data strongly suggest a tight link between Dpp signaling and the Dachshund gene, a functional relationship between vertebrate Dach and BMP signaling remains undemonstrated. dipalmitoylphosphatidylserine 63-66 dachshund Drosophila melanogaster 85-94 15668176-4 2005 For example, dpp signaling acts by silencing transcription of the differentiation factor, bam, in GSCs. dipalmitoylphosphatidylserine 13-16 bag of marbles Drosophila melanogaster 90-93 15668176-10 2005 dpp- and piwi-dependent signaling act synergistically in GSCs to silence bam, whereas pumilio represses translation of differentiation-promoting mRNAs. dipalmitoylphosphatidylserine 0-3 bag of marbles Drosophila melanogaster 73-76 15566157-5 2004 We demonstrated the hydrolysis reaction in DPPC (dipalmitoyl phosphatidylcholine)/DPPS (dipalmitoyl phosphatidylserine)-mixed monolayers by phospholipase A2 by using the system. dipalmitoylphosphatidylserine 82-86 phospholipase A2 group IB Homo sapiens 140-156 15566157-5 2004 We demonstrated the hydrolysis reaction in DPPC (dipalmitoyl phosphatidylcholine)/DPPS (dipalmitoyl phosphatidylserine)-mixed monolayers by phospholipase A2 by using the system. dipalmitoylphosphatidylserine 88-118 phospholipase A2 group IB Homo sapiens 140-156 15459107-8 2004 Despite this lack of conservation outside mammals, the Msx2 BMP-responsive element serves as an accurate readout of Dpp signaling in a distantly related bilaterian - Drosophila. dipalmitoylphosphatidylserine 116-119 msh homeobox 2 Homo sapiens 55-59 15459107-8 2004 Despite this lack of conservation outside mammals, the Msx2 BMP-responsive element serves as an accurate readout of Dpp signaling in a distantly related bilaterian - Drosophila. dipalmitoylphosphatidylserine 116-119 decapentaplegic Drosophila melanogaster 60-63 22062652-5 2005 The results showed that potential activity of muscle DPP I decreased gradually from 8608.23 to 1842.06 Ug(-1) before loft-aging and then increased gradually from 1842.06 to 12196.60 Ug(-1) at the end, while that of muscle DPP IV decreased continuously and about 11% of the initial potential activity was left at the end of processing. dipalmitoylphosphatidylserine 53-56 dipeptidyl peptidase 4 Sus scrofa 222-228 15531371-3 2004 Here we report that Bmp4 of the Dpp class has a unique expression pattern in the developing testis and epididymis. dipalmitoylphosphatidylserine 32-35 bone morphogenetic protein 4 Homo sapiens 20-24 14973291-5 2004 Similar to dpp, gbb encodes another Bmp niche signal that is essential for maintaining GSCs. dipalmitoylphosphatidylserine 11-14 glass bottom boat Drosophila melanogaster 36-39 15188438-4 2004 The function of spoonbill appears to be required for dpp transcription in a specialized population of follicle cells and for the selective transport of grk mRNA from the nurse cells into the oocyte, as well as for its proper localization and translation. dipalmitoylphosphatidylserine 53-56 spoonbill Drosophila melanogaster 16-25 15188438-4 2004 The function of spoonbill appears to be required for dpp transcription in a specialized population of follicle cells and for the selective transport of grk mRNA from the nurse cells into the oocyte, as well as for its proper localization and translation. dipalmitoylphosphatidylserine 53-56 gurken Drosophila melanogaster 152-155 15128661-4 2004 EVE expression in the dorsalmost mesodermal cells is induced in response to DPP secreted by the dorsal epidermal cells. dipalmitoylphosphatidylserine 76-79 even skipped Drosophila melanogaster 0-3 14627718-2 2003 We have cloned a new gene, sma-9, that encodes the C. elegans homolog of Schnurri, a large zinc finger transcription factor that regulates dpp target genes in Drosophila. dipalmitoylphosphatidylserine 139-142 Transcription factor sma-9 Caenorhabditis elegans 27-32 14719796-3 2003 Chemical modifications or substitutions of GLP-1 at His7 or Ala8 improve resistance to DPP-IV action, but this often reduces potency. dipalmitoylphosphatidylserine 87-90 glucagon Mus musculus 43-48 14534137-9 2003 Both BMP ligands, DPP and Screw, are required for nuclear co-SMAD responses during these stages. dipalmitoylphosphatidylserine 18-21 decapentaplegic Drosophila melanogaster 5-8 14534137-9 2003 Both BMP ligands, DPP and Screw, are required for nuclear co-SMAD responses during these stages. dipalmitoylphosphatidylserine 18-21 Smad on X Drosophila melanogaster 61-65 14639619-6 2004 These results suggest that DPP-CNDAC-liposomes modified with MT1-MMP-targeted peptide are useful for cancer anti-neovascular therapy (ANET), namely, tumor growth suppression by damage to angiogenic endothelial cells. dipalmitoylphosphatidylserine 27-30 matrix metallopeptidase 14 Homo sapiens 61-68 14627718-2 2003 We have cloned a new gene, sma-9, that encodes the C. elegans homolog of Schnurri, a large zinc finger transcription factor that regulates dpp target genes in Drosophila. dipalmitoylphosphatidylserine 139-142 schnurri Drosophila melanogaster 73-81 12376101-3 2002 Omb is expressed in Drosophila wing development in response to a signalling cascade involving Hedgehog and Dpp. dipalmitoylphosphatidylserine 107-110 bifid Drosophila melanogaster 0-3 14568549-4 2003 Dpp initially switches on the early eye genes so and eya in the eye field. dipalmitoylphosphatidylserine 0-3 eyes absent Drosophila melanogaster 53-56 14568549-6 2003 We show that Dpp negatively regulates EGFR signaling, thereby increasing the amount of cell death in the dorsal midline. dipalmitoylphosphatidylserine 13-16 Epidermal growth factor receptor Drosophila melanogaster 38-42 14568549-8 2003 Loss of either Dpp or its downstream target, Zen, abolishes head epidermis fate and leads to the misexpression of dp-ERK in the dorsal midline. dipalmitoylphosphatidylserine 15-18 rolled Drosophila melanogaster 114-120 14568549-10 2003 Ectopic expression of activated EGFR inhibits the Dpp target race and thereby causes cyclopia and defective head involution. dipalmitoylphosphatidylserine 50-53 Epidermal growth factor receptor Drosophila melanogaster 32-36 12967332-10 2003 FSH concentrations were elevated at 105 dpc (MS) and 1 dpp (WC) but declined thereafter with advancing postnatal age in both breeds. dipalmitoylphosphatidylserine 55-58 FSH Sus scrofa 0-3 12662155-10 2003 In contrast with the previous results suggesting that DPP9 is inactive, we show that DPP9 is a DPP, hydrolysing Ala-Pro-(7-amino-4-methyl-coumarin) with similar pH-specificity and protease-inhibitor-sensitivity to those of DPP4 and DPP8. dipalmitoylphosphatidylserine 54-57 dipeptidyl peptidase 9 Homo sapiens 85-89 12924019-9 2002 The comparison of the inhibitor interaction with DPP-plasmin, mini-plasminogen and micro-plasminogen displayed the possibility of the additional region existence in catalytic domain. dipalmitoylphosphatidylserine 49-52 plasminogen Homo sapiens 53-60 14500904-11 2003 Phospho-Mad and the downstream target gene vestigial were elevated in l(2)gl tumors, thus linking Drosophila neoplasia to the Dpp (TGF-beta-like) signal pathway. dipalmitoylphosphatidylserine 126-129 decapentaplegic Drosophila melanogaster 131-139 14500904-12 2003 The activation of the Dpp pathway in l(2)gl tumors occurred only in the presence of Sema-5c. dipalmitoylphosphatidylserine 22-25 Semaphorin 5c Drosophila melanogaster 84-91 12900462-7 2003 We show that the restriction of eyg activity to the anterior-central region of the wing disc is achieved by the antagonistic regulatory activities of the Iro and pnr genes, which promote eyg expression, and those of the Hh and Dpp pathways, which act as repressors. dipalmitoylphosphatidylserine 227-230 eyegone Drosophila melanogaster 32-35 12900462-7 2003 We show that the restriction of eyg activity to the anterior-central region of the wing disc is achieved by the antagonistic regulatory activities of the Iro and pnr genes, which promote eyg expression, and those of the Hh and Dpp pathways, which act as repressors. dipalmitoylphosphatidylserine 227-230 caupolican Drosophila melanogaster 154-157 12904562-13 2003 Construction of a phylogenetic tree demonstrated that the DPP-IV of P. albensis clusters with other DPP-IVs found in bacteria of the Cytophaga-Flexibacter-Bacteroidaceae (CFB) phylum, which are more closely related to eukaryotic DPP-IVs than the DPP-IV-like enzyme (PepX) of the lactic acid bacteria. dipalmitoylphosphatidylserine 58-61 dipeptidyl peptidase 4 Homo sapiens 100-106 12904562-13 2003 Construction of a phylogenetic tree demonstrated that the DPP-IV of P. albensis clusters with other DPP-IVs found in bacteria of the Cytophaga-Flexibacter-Bacteroidaceae (CFB) phylum, which are more closely related to eukaryotic DPP-IVs than the DPP-IV-like enzyme (PepX) of the lactic acid bacteria. dipalmitoylphosphatidylserine 100-103 dipeptidyl peptidase 4 Homo sapiens 58-64 11967165-2 2002 Direct visualisation in the Drosophila embryo of Sog, a Dpp/Scw inhibitor, has now revealed a graded distribution established by degradation and endocytosis. dipalmitoylphosphatidylserine 56-59 short gastrulation Drosophila melanogaster 49-52 12387748-5 2002 Strongest to weakest potencies were observed as DPP --> BBP --> DBP --> DCHP --> DHP --> DPrP --> DEHP --> DEP. dipalmitoylphosphatidylserine 48-51 D-box binding PAR bZIP transcription factor Bos taurus 70-73 11944934-2 2002 A similar regulatory interaction has been defined in Drosophila embryos where Dpp signaling mediated by the Smad homologues Mad and Medea directly regulates early cardiac expression of tinman. dipalmitoylphosphatidylserine 78-81 Smad on X Drosophila melanogaster 108-112 11865058-2 2002 By a genetic screen of mutations affecting dorsal closure in Drosophila, we have now identified a multidomain protein, connector of kinase to AP-1 (cka), that functions in the DJNK pathway and controls the localized expression of dpp in the leading-edge cells. dipalmitoylphosphatidylserine 230-233 Connector of kinase to AP-1 Drosophila melanogaster 148-151 11897392-15 2002 NEP, ACE and the deamidase are likely to be more efficient than the common DPP IV activity at terminating neuropeptide signalling since they cleave close to the C-terminus of the tachykinin, a region essential for maintaining biological activity. dipalmitoylphosphatidylserine 75-78 Neprilysin-like 11 Drosophila melanogaster 0-3 11865058-2 2002 By a genetic screen of mutations affecting dorsal closure in Drosophila, we have now identified a multidomain protein, connector of kinase to AP-1 (cka), that functions in the DJNK pathway and controls the localized expression of dpp in the leading-edge cells. dipalmitoylphosphatidylserine 230-233 basket Drosophila melanogaster 176-180 11861483-4 2002 Previous studies have shown that Dpp forms a gradient along the AP axis that patterns the wing, that Dpp receptors are autonomously required for wing cell proliferation, and that ectopic expression of either Dpp or an activated Dpp receptor, Tkv(Q253D), causes overgrowth. dipalmitoylphosphatidylserine 33-36 thickveins Drosophila melanogaster 242-245 11861483-4 2002 Previous studies have shown that Dpp forms a gradient along the AP axis that patterns the wing, that Dpp receptors are autonomously required for wing cell proliferation, and that ectopic expression of either Dpp or an activated Dpp receptor, Tkv(Q253D), causes overgrowth. dipalmitoylphosphatidylserine 101-104 thickveins Drosophila melanogaster 242-245 11861483-6 2002 Increasing Dpp signaling by expressing Tkv(Q253D) accelerated wing cell growth and cell cycle progression in a coordinate and cell-autonomous manner. dipalmitoylphosphatidylserine 11-14 thickveins Drosophila melanogaster 39-42 11861483-7 2002 Conversely, autonomously inhibiting Dpp signaling using a pathway specific inhibitor, Dad, or a mutation in tkv, slowed wing cell growth and division, also in a coordinate fashion. dipalmitoylphosphatidylserine 36-39 thickveins Drosophila melanogaster 108-111 11861483-9 2002 Among the known Dpp targets, vestigial was the only one tested that was required for Tkv(Q253D)-induced growth. dipalmitoylphosphatidylserine 16-19 thickveins Drosophila melanogaster 85-88 11731450-6 2001 Lowering Dpp levels (in dpp heterozygotes or hypomorphic alleles) results in a "cyclops" phenotype, where mid-dorsal head epidermis is transformed into dorsolateral structures, i.e. eye/optic lobe tissue, which causes a continuous visual primordium across the dorsal midline. dipalmitoylphosphatidylserine 24-27 decapentaplegic Drosophila melanogaster 9-12 11834453-2 2002 DPP IV inhibition reduces exogenous GLP-1 degradation, but the extent of endogenous incretin protection has not been fully assessed, largely because suitable assays which distinguish between intact and degraded peptides have been unavailable. dipalmitoylphosphatidylserine 0-3 glucagon Canis lupus familiaris 36-41 11834453-10 2002 We have concluded that DPP IV inhibition with NVP-DPP728 prevents N-terminal degradation of endogenous incretins in vivo, resulting in increased plasma concentrations of intact, biologically active GIP and GLP-1. dipalmitoylphosphatidylserine 23-26 GIP Canis lupus familiaris 198-201 11834453-10 2002 We have concluded that DPP IV inhibition with NVP-DPP728 prevents N-terminal degradation of endogenous incretins in vivo, resulting in increased plasma concentrations of intact, biologically active GIP and GLP-1. dipalmitoylphosphatidylserine 23-26 glucagon Canis lupus familiaris 206-211 11731463-4 2001 This function of pnr is necessary for the activation of the Dpp pathway in the epidermal cells implicated in dorsal closure and is not mediated by the JNK pathway, which is also necessary for Dpp activity in these cells. dipalmitoylphosphatidylserine 60-63 pannier Drosophila melanogaster 17-20 11598015-0 2001 Brinker requires two corepressors for maximal and versatile repression in Dpp signalling. dipalmitoylphosphatidylserine 74-77 brinker Drosophila melanogaster 0-7 11598015-3 2001 Recent studies show that responses to graded Dpp activity also require an input from a complementary and opposing gradient of Brinker (Brk), a transcriptional repressor protein encoded by a Dpp target gene. dipalmitoylphosphatidylserine 45-48 brinker Drosophila melanogaster 126-133 11598015-3 2001 Recent studies show that responses to graded Dpp activity also require an input from a complementary and opposing gradient of Brinker (Brk), a transcriptional repressor protein encoded by a Dpp target gene. dipalmitoylphosphatidylserine 45-48 brinker Drosophila melanogaster 135-138 11598015-3 2001 Recent studies show that responses to graded Dpp activity also require an input from a complementary and opposing gradient of Brinker (Brk), a transcriptional repressor protein encoded by a Dpp target gene. dipalmitoylphosphatidylserine 190-193 brinker Drosophila melanogaster 126-133 11598015-3 2001 Recent studies show that responses to graded Dpp activity also require an input from a complementary and opposing gradient of Brinker (Brk), a transcriptional repressor protein encoded by a Dpp target gene. dipalmitoylphosphatidylserine 190-193 brinker Drosophila melanogaster 135-138 11598015-5 2001 By analysing transcriptional outcomes arising from the genetic removal of these corepressors, and by ectopically expressing Brk variants in the embryo, we demonstrate that these corepressors are alternatively used by Brk for repressing some Dpp-responsive genes, whereas for repressing other distinct target genes they are not required. dipalmitoylphosphatidylserine 241-244 brinker Drosophila melanogaster 217-220 11598015-6 2001 Our results show that Brk utilizes multiple means to repress its endogenous target genes, allowing repression of a multitude of complex Dpp target promoters. dipalmitoylphosphatidylserine 136-139 brinker Drosophila melanogaster 22-25 11564711-11 2001 GLP-1 Aha(8) (24 nmol/kg) administered sc to fasted Zucker (fa/fa) rats (mean blood glucose, 195 +/- 32 mg/dl) lowered blood glucose levels to a nadir of 109 +/- 3 mg/dl, and it remained significantly lower for 8 h. Matrix-assisted linear desorption ionization-time of flight mass spectrometry of GLP-1 Aha(8) incubated with DPP IV (37 C, 2 h) did not exhibit an N-terminal degradation product. dipalmitoylphosphatidylserine 325-328 glucagon Rattus norvegicus 0-5 11703946-1 2001 We identified Drosophila Smurf (DSmurf) as a negative regulator of signaling by the BMP2/4 ortholog DPP during embryonic dorsal-ventral patterning. dipalmitoylphosphatidylserine 100-103 SMAD specific E3 ubiquitin protein ligase Drosophila melanogaster 25-30 11703946-1 2001 We identified Drosophila Smurf (DSmurf) as a negative regulator of signaling by the BMP2/4 ortholog DPP during embryonic dorsal-ventral patterning. dipalmitoylphosphatidylserine 100-103 SMAD specific E3 ubiquitin protein ligase Drosophila melanogaster 32-38 11703946-3 2001 The essential function of DSmurf is restricted to its action on the DPP pathway. dipalmitoylphosphatidylserine 68-71 SMAD specific E3 ubiquitin protein ligase Drosophila melanogaster 26-32 11543614-6 2001 Furthermore, the expression of the TGF-beta homolog dpp, which is under the control of hep in embryos, is not coupled to JNK activity during oogenesis. dipalmitoylphosphatidylserine 52-55 hemipterous Drosophila melanogaster 87-90 11703946-4 2001 DSmurf has two distinct, possibly mechanistically separate, functions in controlling DPP signaling. dipalmitoylphosphatidylserine 85-88 SMAD specific E3 ubiquitin protein ligase Drosophila melanogaster 0-6 11703946-5 2001 Prior to gastrulation, DSmurf mutations cause a spatial increase in the DPP gradient, as evidenced by ventrolateral expansion in expression domains of target genes representing all known signaling thresholds. dipalmitoylphosphatidylserine 72-75 SMAD specific E3 ubiquitin protein ligase Drosophila melanogaster 23-29 11703946-6 2001 After gastrulation, DSmurf mutations cause a temporal delay in downregulation of earlier DPP signals, resulting in a lethal defect in hindgut organogenesis. dipalmitoylphosphatidylserine 89-92 SMAD specific E3 ubiquitin protein ligase Drosophila melanogaster 20-26 11311248-1 2001 "division abnormally delayed"(dally), a Drosophila member of the glypican family, has been implicated in Dpp and Wg signaling. dipalmitoylphosphatidylserine 105-108 division abnormally delayed Drosophila melanogaster 30-35 11401407-3 2001 Here we show that Bmp2, a member of the Dpp class of the Bmp superfamily, also plays a role in PGC generation. dipalmitoylphosphatidylserine 40-43 bone morphogenetic protein 2 Mus musculus 18-22 11401407-3 2001 Here we show that Bmp2, a member of the Dpp class of the Bmp superfamily, also plays a role in PGC generation. dipalmitoylphosphatidylserine 40-43 bone morphogenetic protein 2 Mus musculus 18-21 11401407-3 2001 Here we show that Bmp2, a member of the Dpp class of the Bmp superfamily, also plays a role in PGC generation. dipalmitoylphosphatidylserine 40-43 progastricsin (pepsinogen C) Mus musculus 95-98 11505367-8 2001 From day 21 an increase in the size and number of RCC positive for Cx43 and 3betaHSD was found that continued at 24, 26 and 28 days and reached a maximum at 35 and 60 dpp. dipalmitoylphosphatidylserine 167-170 gap junction protein, alpha 1 Mus musculus 67-71 11427739-2 2001 Genes encoding Bmp4 of the Dpp class and Bmp8b of the 60A class are expressed in the extraembryonic ectoderm and targeted mutation of either results in severe defects in PGC formation. dipalmitoylphosphatidylserine 27-30 bone morphogenetic protein 4 Mus musculus 15-19 11427739-3 2001 It has been shown that heterodimers of DPP and 60A classes of bone morphogenetic proteins (BMPs) are more potent than each homodimers in bone and mesoderm induction in vitro, suggesting that BMP4 and BMP8B may form heterodimers to induce PGCs. dipalmitoylphosphatidylserine 39-42 bone morphogenetic protein 4 Mus musculus 191-195 11427739-3 2001 It has been shown that heterodimers of DPP and 60A classes of bone morphogenetic proteins (BMPs) are more potent than each homodimers in bone and mesoderm induction in vitro, suggesting that BMP4 and BMP8B may form heterodimers to induce PGCs. dipalmitoylphosphatidylserine 39-42 bone morphogenetic protein 8b Mus musculus 200-205 11222150-7 2001 In spite of the uniform expression of Scw, pMad expansion is restricted to the dorsal domain of the embryo where Dpp is expressed. dipalmitoylphosphatidylserine 113-116 Mothers against dpp Drosophila melanogaster 43-47 11222150-9 2001 Indeed, the early pMad pattern is abolished when either the Scw receptor Saxophone (Sax), the Dpp receptor Thickveins (Tkv), or Dpp are removed. dipalmitoylphosphatidylserine 94-97 Mothers against dpp Drosophila melanogaster 18-22 11222150-11 2001 From this stage onward, activation by Scw is no longer required, and Dpp suffices to induce high levels of pMad. dipalmitoylphosphatidylserine 69-72 Mothers against dpp Drosophila melanogaster 107-111 11044605-2 2000 Since AP-1 is known as a mediator of auto-regulatory loops both in the case of the Drosophila dpp and the mammalian TGF-beta genes, we have analysed the potential of Xenopus c-Jun (AP-1) as a mediator of BMP-4 expression during Xenopus development. dipalmitoylphosphatidylserine 94-97 Jun-related antigen Drosophila melanogaster 6-10 11076769-7 2000 Mesodermal Slp is then sufficient to abrogate the induction of bagpipe by Dpp/Tinman, which explains the periodic arrangement of trunk visceral mesoderm primordia in wild type embryos. dipalmitoylphosphatidylserine 74-77 sloppy paired 1 Drosophila melanogaster 11-14 11076769-7 2000 Mesodermal Slp is then sufficient to abrogate the induction of bagpipe by Dpp/Tinman, which explains the periodic arrangement of trunk visceral mesoderm primordia in wild type embryos. dipalmitoylphosphatidylserine 74-77 bagpipe Drosophila melanogaster 63-70 11071761-2 2000 Dpp signaling culminates in the phosphorylation and nuclear translocation of Mothers against dpp (Mad), a receptor-specific Smad that can bind DNA and regulate the transcription of Dpp-responsive genes. dipalmitoylphosphatidylserine 93-96 decapentaplegic Drosophila melanogaster 0-3 11071761-2 2000 Dpp signaling culminates in the phosphorylation and nuclear translocation of Mothers against dpp (Mad), a receptor-specific Smad that can bind DNA and regulate the transcription of Dpp-responsive genes. dipalmitoylphosphatidylserine 93-96 decapentaplegic Drosophila melanogaster 181-184 10912800-8 2000 Neuraminidase digestion showed that the most striking effect of BGN was a blockade of DPP IV sialylation in both MDCK and Caco-2 cells. dipalmitoylphosphatidylserine 86-89 biglycan Canis lupus familiaris 64-67 10862738-4 2000 To investigate the mechanisms by which the two activities of Ci exert their opposite transcriptional effect, we dissect here the imaginal disc enhancer of the dpp gene, which responds to both activities of Ci. dipalmitoylphosphatidylserine 159-162 cubitus interruptus Drosophila melanogaster 61-63 10862738-4 2000 To investigate the mechanisms by which the two activities of Ci exert their opposite transcriptional effect, we dissect here the imaginal disc enhancer of the dpp gene, which responds to both activities of Ci. dipalmitoylphosphatidylserine 159-162 cubitus interruptus Drosophila melanogaster 206-208 10862738-6 2000 We further show that the enhancer sequences of patched, a gene responding only to the activator form of Ci, effectively integrate also the repressor activity of Ci if placed into a dpp context. dipalmitoylphosphatidylserine 181-184 cubitus interruptus Drosophila melanogaster 104-106 10862738-6 2000 We further show that the enhancer sequences of patched, a gene responding only to the activator form of Ci, effectively integrate also the repressor activity of Ci if placed into a dpp context. dipalmitoylphosphatidylserine 181-184 cubitus interruptus Drosophila melanogaster 161-163 10678169-5 2000 HH induces dpp in these cells; it also attenuates their response to DPP by downregulating expression of the DPP receptor thick veins (tkv). dipalmitoylphosphatidylserine 11-14 hedgehog Drosophila melanogaster 0-2 10781936-6 2000 By performing somatic clone experiments with these new amorphic slmb alleles, we have determined that regulation of Dpp and Wg morphogens by Slmb could be different from what has already been published. dipalmitoylphosphatidylserine 116-119 supernumerary limbs Drosophila melanogaster 64-68 10781936-6 2000 By performing somatic clone experiments with these new amorphic slmb alleles, we have determined that regulation of Dpp and Wg morphogens by Slmb could be different from what has already been published. dipalmitoylphosphatidylserine 116-119 supernumerary limbs Drosophila melanogaster 141-145 10781936-13 2000 This result suggests that Slmb is likely to be involved, in addition to its repression role on Dpp and Wg, in some other essential cellular mechanism, as in the absence of Slmb, cell affinities are dramatically modified regardless of the deregulated morphogen and of the type of imaginal disc. dipalmitoylphosphatidylserine 95-98 supernumerary limbs Drosophila melanogaster 26-30 10648233-0 2000 Drosophila bunched integrates opposing DPP and EGF signals to set the operculum boundary. dipalmitoylphosphatidylserine 39-42 bunched Drosophila melanogaster 11-18 10648233-5 2000 DPP induces expression of the enhancer trap reporter A359 and represses expression of bunched, which encodes a protein similar to the mammalian transcription factor TSC-22. dipalmitoylphosphatidylserine 0-3 bunched Drosophila melanogaster 86-93 10648233-5 2000 DPP induces expression of the enhancer trap reporter A359 and represses expression of bunched, which encodes a protein similar to the mammalian transcription factor TSC-22. dipalmitoylphosphatidylserine 0-3 TSC22 domain family member 1 Homo sapiens 165-171 10648233-6 2000 Second, DPP signaling indirectly regulates A359 expression in these cells by downregulating expression of bunched. dipalmitoylphosphatidylserine 8-11 bunched Drosophila melanogaster 106-113 10648233-12 2000 Thus, the balance of DPP and EGF signals sets the boundary of bunched expression. dipalmitoylphosphatidylserine 21-24 bunched Drosophila melanogaster 62-69 10821766-3 2000 Both the Dpp and the Wg pathways are involved in hth repression. dipalmitoylphosphatidylserine 9-12 homothorax Drosophila melanogaster 49-52 10821766-4 2000 Cells unable to process the Dpp (lacking thick veins or Mothers against Dpp activity) or the Wg (lacking dishevelled function) signal express hth in the wing pouch. dipalmitoylphosphatidylserine 28-31 homothorax Drosophila melanogaster 142-145 10742112-8 2000 Our results suggest that Mirror and Notch induce secretion of diffusible morphogens and we have identified TGF-beta (encoded by dpp) as such a molecule in germarium. dipalmitoylphosphatidylserine 128-131 maverick Drosophila melanogaster 107-115 10704850-1 2000 BMP2, like its Drosophila homologue dpp, is an important signaling molecule for specification of cardiogenic mesoderm in vertebrates. dipalmitoylphosphatidylserine 36-39 bone morphogenetic protein 2 Gallus gallus 0-4 10075933-5 1999 Our results provide evidence that CBP functions as a co-activator during Dpp signalling, and they suggest that Mad may recruit CBP to effect the transcriptional activation of Dpp-responsive genes during development. dipalmitoylphosphatidylserine 73-76 sarcoplasmic calcium-binding protein Drosophila melanogaster 34-37 10410909-1 1999 In mouse, tissue-specific developmental de novo methylation of the proto-oncogene c-fos, which is abundantly expressed during embryonic stages, occurs perinatally (between the day of birth to 20 dpp) and is maintained in the adult. dipalmitoylphosphatidylserine 195-198 FBJ osteosarcoma oncogene Mus musculus 67-87 10075933-5 1999 Our results provide evidence that CBP functions as a co-activator during Dpp signalling, and they suggest that Mad may recruit CBP to effect the transcriptional activation of Dpp-responsive genes during development. dipalmitoylphosphatidylserine 73-76 Mothers against dpp Drosophila melanogaster 111-114 10075933-0 1999 A function of CBP as a transcriptional co-activator during Dpp signalling. dipalmitoylphosphatidylserine 59-62 sarcoplasmic calcium-binding protein Drosophila melanogaster 14-17 10075933-2 1999 Here, we report that Drosophila CBP loss-of-function mutants show specific defects which mimic those seen in mutants that lack the extracellular signal Dpp or its effector Mad. dipalmitoylphosphatidylserine 152-155 sarcoplasmic calcium-binding protein Drosophila melanogaster 32-35 10075933-5 1999 Our results provide evidence that CBP functions as a co-activator during Dpp signalling, and they suggest that Mad may recruit CBP to effect the transcriptional activation of Dpp-responsive genes during development. dipalmitoylphosphatidylserine 73-76 sarcoplasmic calcium-binding protein Drosophila melanogaster 127-130 10075933-5 1999 Our results provide evidence that CBP functions as a co-activator during Dpp signalling, and they suggest that Mad may recruit CBP to effect the transcriptional activation of Dpp-responsive genes during development. dipalmitoylphosphatidylserine 175-178 sarcoplasmic calcium-binding protein Drosophila melanogaster 34-37 10075933-3 1999 Furthermore, we find that CBP loss severely compromises the ability of Dpp target enhancers to respond to endogenous or exogenous Dpp. dipalmitoylphosphatidylserine 71-74 sarcoplasmic calcium-binding protein Drosophila melanogaster 26-29 10075933-3 1999 Furthermore, we find that CBP loss severely compromises the ability of Dpp target enhancers to respond to endogenous or exogenous Dpp. dipalmitoylphosphatidylserine 130-133 sarcoplasmic calcium-binding protein Drosophila melanogaster 26-29 10075933-5 1999 Our results provide evidence that CBP functions as a co-activator during Dpp signalling, and they suggest that Mad may recruit CBP to effect the transcriptional activation of Dpp-responsive genes during development. dipalmitoylphosphatidylserine 175-178 Mothers against dpp Drosophila melanogaster 111-114 10075933-5 1999 Our results provide evidence that CBP functions as a co-activator during Dpp signalling, and they suggest that Mad may recruit CBP to effect the transcriptional activation of Dpp-responsive genes during development. dipalmitoylphosphatidylserine 175-178 sarcoplasmic calcium-binding protein Drosophila melanogaster 127-130 10022918-5 1999 Dpp is a secretory ligand belonging to the transforming growth factor beta superfamily which triggers various morphogenetic processes through interaction with the receptor Thick veins (Tkv). dipalmitoylphosphatidylserine 0-3 thickveins Drosophila melanogaster 172-183 10204082-6 1999 This enzyme therefore combines properties typical of both DPP II and III and differs from all previously described DPPs. dipalmitoylphosphatidylserine 115-119 dipeptidyl peptidase 7 Homo sapiens 58-64 10022918-7 1999 Mosaic analysis revealed that D-p38b regulates the Tkv-dependent transcription of the optomotor-blind (omb) gene in non-Dpp-producing cells, indicating that the site of D-p38b action is downstream of Tkv. dipalmitoylphosphatidylserine 120-123 p38b MAP kinase Drosophila melanogaster 30-36 10022918-7 1999 Mosaic analysis revealed that D-p38b regulates the Tkv-dependent transcription of the optomotor-blind (omb) gene in non-Dpp-producing cells, indicating that the site of D-p38b action is downstream of Tkv. dipalmitoylphosphatidylserine 120-123 bifid Drosophila melanogaster 103-106 10022918-9 1999 These results demonstrate that p38, in addition to its role as a transducer of emergency stress signaling, may function to modulate Dpp signaling. dipalmitoylphosphatidylserine 132-135 p38b MAP kinase Drosophila melanogaster 31-34 9872957-2 1999 Since then, only two haplolethals, 22F1-2 and 16F, have been directly linked to identified genes, dpp and wupA, respectively. dipalmitoylphosphatidylserine 98-101 l(1)14Fa Drosophila melanogaster 46-49 9834190-3 1999 Wingless and Dpp define both domains by activating Dll and by repressing Hth in the distal region of the disc. dipalmitoylphosphatidylserine 13-16 homothorax Drosophila melanogaster 73-76 9834190-5 1999 Hth functions to reduce the sensitivity of proximal cells to Wg and Dpp. dipalmitoylphosphatidylserine 68-71 homothorax Drosophila melanogaster 0-3 9882489-5 1998 The subsequent dorsal mesoderm-restricted mef2 expression is mediated through a 460-bp dpp-responsive regulatory module, which involves the function of the Smad4 homolog Medea and contains several binding sites for Medea and Mad. dipalmitoylphosphatidylserine 87-90 Myocyte enhancer factor 2 Drosophila melanogaster 42-46 9882489-5 1998 The subsequent dorsal mesoderm-restricted mef2 expression is mediated through a 460-bp dpp-responsive regulatory module, which involves the function of the Smad4 homolog Medea and contains several binding sites for Medea and Mad. dipalmitoylphosphatidylserine 87-90 Medea Drosophila melanogaster 156-161 9811580-3 1998 knirps/knirps related activity is necessary to mediate DPP signaling which is required for tracheal cell migration and formation of the dorsal and ventral branches. dipalmitoylphosphatidylserine 55-58 knirps Drosophila melanogaster 0-6 9811580-3 1998 knirps/knirps related activity is necessary to mediate DPP signaling which is required for tracheal cell migration and formation of the dorsal and ventral branches. dipalmitoylphosphatidylserine 55-58 knirps-like Drosophila melanogaster 7-21 9811580-7 1998 spalt expression is maintained by the EGF receptor pathway and, hence, some of the opposing activities of the EGF and DPP signaling pathways are mediated by spalt and knirps/knirps related. dipalmitoylphosphatidylserine 118-121 spalt major Drosophila melanogaster 0-5 9811580-7 1998 spalt expression is maintained by the EGF receptor pathway and, hence, some of the opposing activities of the EGF and DPP signaling pathways are mediated by spalt and knirps/knirps related. dipalmitoylphosphatidylserine 118-121 spalt major Drosophila melanogaster 157-162 9811580-7 1998 spalt expression is maintained by the EGF receptor pathway and, hence, some of the opposing activities of the EGF and DPP signaling pathways are mediated by spalt and knirps/knirps related. dipalmitoylphosphatidylserine 118-121 knirps Drosophila melanogaster 167-173 9811580-7 1998 spalt expression is maintained by the EGF receptor pathway and, hence, some of the opposing activities of the EGF and DPP signaling pathways are mediated by spalt and knirps/knirps related. dipalmitoylphosphatidylserine 118-121 knirps-like Drosophila melanogaster 174-188 18726213-3 1998 The activity of purified PKC from rat brains was measured in the vesicles made up of dipalmitoylphosphatidylserine (DPPS), 1, 2-sn-diolein (DOG) and different molar ratios of 1-palmitoyl-sn-glycerol-3-phosphoryl-choline (C16:0 lyso-PC). dipalmitoylphosphatidylserine 85-114 protein kinase C, gamma Rattus norvegicus 25-28 9827802-6 1998 Further, we show that the extracellular protein SOG can antagonize SCW, thus limiting its ability to augment DPP signaling in a graded manner. dipalmitoylphosphatidylserine 109-112 short gastrulation Drosophila melanogaster 48-51 18726213-3 1998 The activity of purified PKC from rat brains was measured in the vesicles made up of dipalmitoylphosphatidylserine (DPPS), 1, 2-sn-diolein (DOG) and different molar ratios of 1-palmitoyl-sn-glycerol-3-phosphoryl-choline (C16:0 lyso-PC). dipalmitoylphosphatidylserine 116-120 protein kinase C, gamma Rattus norvegicus 25-28 18726213-9 1998 When C16:0 lyso-PC/DPPS molar ratio was 0.234, the two areas had the broadest boundary and the activation of PKC was the highest. dipalmitoylphosphatidylserine 19-23 protein kinase C, gamma Rattus norvegicus 109-112 18726213-10 1998 When the ratio was over 0.434, the phase transition of DPPS disappeared; micelle tended to substitute the structure of bilayer; the activity of PKC was inhibited completely. dipalmitoylphosphatidylserine 55-59 protein kinase C, gamma Rattus norvegicus 144-147 18726213-11 1998 DOG can stabilize the bilayer structure of membrane, so the C16:0 lyso-PC/DPPS molar ratios to inhibit PKC in lipid mixture with DOG are higher than that without DOG. dipalmitoylphosphatidylserine 74-78 protein kinase C, gamma Rattus norvegicus 103-106 9827801-2 1998 In embryos lacking dpp signaling, increasing the level of TKV activity promotes progressively more dorsal cell types, while activation of SAX alone has no phenotypic consequences. dipalmitoylphosphatidylserine 19-22 thickveins Drosophila melanogaster 58-61 9694800-0 1998 Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm. dipalmitoylphosphatidylserine 88-91 Medea Drosophila melanogaster 0-4 9827801-4 1998 Functional experiments suggest the two receptors have different ligands: DPP acts through TKV, and SCW acts through SAX. dipalmitoylphosphatidylserine 73-76 thickveins Drosophila melanogaster 90-93 9827802-3 1998 Using dominant-negative forms of the type I receptors SAX and TKV, we demonstrate that SAX mediates the SCW signal, while TKV is required for both DPP and SCW activity. dipalmitoylphosphatidylserine 147-150 thickveins Drosophila melanogaster 122-125 9827802-5 1998 SAX and TKV act synergistically, suggesting a mechanism for integration of the SCW and DPP signals. dipalmitoylphosphatidylserine 87-90 thickveins Drosophila melanogaster 8-11 9735359-1 1998 In Drosophila wing discs, a morphogen gradient of DPP has been proposed to determine the transcriptional response thresholds of the downstream genes sal and omb. dipalmitoylphosphatidylserine 50-53 bifid Drosophila melanogaster 157-160 9735359-2 1998 We present evidence that the concentration of the type I receptor TKV must be low to allow long-range DPP diffusion. dipalmitoylphosphatidylserine 102-105 thickveins Drosophila melanogaster 66-69 9735359-4 1998 To enhance signaling at low DPP concentrations, we find that a second ligand, GBB, augments DPP/TKV activity. dipalmitoylphosphatidylserine 28-31 glass bottom boat Drosophila melanogaster 78-81 9735359-4 1998 To enhance signaling at low DPP concentrations, we find that a second ligand, GBB, augments DPP/TKV activity. dipalmitoylphosphatidylserine 92-95 glass bottom boat Drosophila melanogaster 78-81 9735359-6 1998 We show that OMB expression in wing discs requires synergistic signaling by multiple ligands and receptors to overcome the limitations imposed on DPP morphogen function by receptor concentration levels. dipalmitoylphosphatidylserine 146-149 bifid Drosophila melanogaster 13-16 9694800-2 1998 In Drosophila, induction of visceral mesoderm, dorsal muscles, and the heart by Dpp is, at least in part, effected through the transcriptional activation and function of the homeobox gene tinman in dorsal mesodermal cells during early embryogenesis. dipalmitoylphosphatidylserine 80-83 tinman Drosophila melanogaster 188-194 9694800-3 1998 Here we present a functional dissection of a tinman enhancer that mediates the Dpp response. dipalmitoylphosphatidylserine 79-82 tinman Drosophila melanogaster 45-51 9381174-3 1997 In dorsal closure, DFos cooperates with DJun by regulating the expression of dpp; Dpp acts as a relay signal that triggers cell shape changes and DFos expression in neighboring cells. dipalmitoylphosphatidylserine 77-80 Jun-related antigen Drosophila melanogaster 40-44 9693372-0 1998 Interplay of signal mediators of decapentaplegic (Dpp): molecular characterization of mothers against dpp, Medea, and daughters against dpp. dipalmitoylphosphatidylserine 102-105 decapentaplegic Drosophila melanogaster 50-53 9693372-4 1998 Mothers against dpp (Mad) is a pathway-specific Smad, whereas Daughters against dpp (Dad) is an inhibitory Smad genetically shown to antagonize Dpp signaling. dipalmitoylphosphatidylserine 16-19 Mothers against dpp Drosophila melanogaster 21-24 9693372-4 1998 Mothers against dpp (Mad) is a pathway-specific Smad, whereas Daughters against dpp (Dad) is an inhibitory Smad genetically shown to antagonize Dpp signaling. dipalmitoylphosphatidylserine 16-19 Mothers against dpp Drosophila melanogaster 48-52 9693372-4 1998 Mothers against dpp (Mad) is a pathway-specific Smad, whereas Daughters against dpp (Dad) is an inhibitory Smad genetically shown to antagonize Dpp signaling. dipalmitoylphosphatidylserine 16-19 Mothers against dpp Drosophila melanogaster 107-111 9693372-4 1998 Mothers against dpp (Mad) is a pathway-specific Smad, whereas Daughters against dpp (Dad) is an inhibitory Smad genetically shown to antagonize Dpp signaling. dipalmitoylphosphatidylserine 16-19 decapentaplegic Drosophila melanogaster 144-147 9680220-12 1998 Expression of the virulence factor SpeB (major cysteine protease) was reduced eightfold in dpp mutants, whereas dpp expression was decreased about fourfold in a Mga virulence regulator mutant. dipalmitoylphosphatidylserine 91-94 cathepsin B Homo sapiens 47-64 9594656-0 1998 Holy Tolloido: Tolloid cleaves SOG/Chordin to free DPP/BMPs. dipalmitoylphosphatidylserine 51-54 chordin Homo sapiens 35-42 9545187-1 1998 Embryos of arthropods and chordates are patterned along the dorso-ventral axis by a gradient of secreted morphogens of the Bmp4/Dpp family. dipalmitoylphosphatidylserine 128-131 bone morphogenetic protein 4 Homo sapiens 123-127 9504926-6 1998 The tight correspondence between both embryonic and postembryonic loss-of-function punt and dpp phenotypes implicates a role for Punt in mediating virtually all Dpp signaling events in Drosophila. dipalmitoylphosphatidylserine 92-95 punt Drosophila melanogaster 129-133 9504926-6 1998 The tight correspondence between both embryonic and postembryonic loss-of-function punt and dpp phenotypes implicates a role for Punt in mediating virtually all Dpp signaling events in Drosophila. dipalmitoylphosphatidylserine 161-164 punt Drosophila melanogaster 83-87 9504926-6 1998 The tight correspondence between both embryonic and postembryonic loss-of-function punt and dpp phenotypes implicates a role for Punt in mediating virtually all Dpp signaling events in Drosophila. dipalmitoylphosphatidylserine 161-164 punt Drosophila melanogaster 129-133 9405368-5 1997 These results indicate that D-Fos is required downstream of the Drosophila JNK signal transduction pathway, consistent with a role in heterodimerization with D-Jun, to activate downstream targets such as dpp. dipalmitoylphosphatidylserine 204-207 kayak Drosophila melanogaster 28-33 9405368-5 1997 These results indicate that D-Fos is required downstream of the Drosophila JNK signal transduction pathway, consistent with a role in heterodimerization with D-Jun, to activate downstream targets such as dpp. dipalmitoylphosphatidylserine 204-207 Jun-related antigen Drosophila melanogaster 158-163 9502724-4 1998 Like dpp, Medea is essential for embryonic dorsal/ventral patterning. dipalmitoylphosphatidylserine 5-8 Medea Drosophila melanogaster 10-15 9502733-6 1998 Furthermore, we show that the necessity for these two closely related, non-redundant Smads, is due to their different signaling properties - upon activation of the Dpp pathway, Mad is required to actively translocate Medea into the nucleus. dipalmitoylphosphatidylserine 164-167 Medea Drosophila melanogaster 217-222 9520331-2 1998 Tld regulates dorsoventral patterning in early Drosophila embryos by enhancing the activity of Dpp, a member of the TGF-beta family most closely related to BMP2 and BMP4. dipalmitoylphosphatidylserine 95-98 tolloid Drosophila melanogaster 0-3 9520331-2 1998 Tld regulates dorsoventral patterning in early Drosophila embryos by enhancing the activity of Dpp, a member of the TGF-beta family most closely related to BMP2 and BMP4. dipalmitoylphosphatidylserine 95-98 bone morphogenetic protein 2 S homeolog Xenopus laevis 156-160 9520331-2 1998 Tld regulates dorsoventral patterning in early Drosophila embryos by enhancing the activity of Dpp, a member of the TGF-beta family most closely related to BMP2 and BMP4. dipalmitoylphosphatidylserine 95-98 bone morphogenetic protein 4 L homeolog Xenopus laevis 165-169 9519708-6 1998 The short duration of action of GLP-1 may be accounted for in part by the enzyme dipeptidyl peptidase 4 (DPP-IV), which cleaves GLP-1 at the NH2-terminus; hence GLP-1 analogs or the lizard peptide exendin-4 that are resistant to DPP-IV cleavage may be more potent GLP-1 molecules in vivo. dipalmitoylphosphatidylserine 105-108 glucagon like peptide 1 receptor Homo sapiens 32-37 9519708-6 1998 The short duration of action of GLP-1 may be accounted for in part by the enzyme dipeptidyl peptidase 4 (DPP-IV), which cleaves GLP-1 at the NH2-terminus; hence GLP-1 analogs or the lizard peptide exendin-4 that are resistant to DPP-IV cleavage may be more potent GLP-1 molecules in vivo. dipalmitoylphosphatidylserine 105-108 glucagon like peptide 1 receptor Homo sapiens 128-133 9519708-6 1998 The short duration of action of GLP-1 may be accounted for in part by the enzyme dipeptidyl peptidase 4 (DPP-IV), which cleaves GLP-1 at the NH2-terminus; hence GLP-1 analogs or the lizard peptide exendin-4 that are resistant to DPP-IV cleavage may be more potent GLP-1 molecules in vivo. dipalmitoylphosphatidylserine 105-108 glucagon like peptide 1 receptor Homo sapiens 128-133 9519708-6 1998 The short duration of action of GLP-1 may be accounted for in part by the enzyme dipeptidyl peptidase 4 (DPP-IV), which cleaves GLP-1 at the NH2-terminus; hence GLP-1 analogs or the lizard peptide exendin-4 that are resistant to DPP-IV cleavage may be more potent GLP-1 molecules in vivo. dipalmitoylphosphatidylserine 105-108 glucagon like peptide 1 receptor Homo sapiens 128-133 9621428-5 1998 Here, we present evidence that zw3 has a dual role in mesoderm development: (1) zw3 acts as an antagonist in cardiogenic wg signal transduction, and (2) zw3 also seems to be required to promote positively the formation of a larger mesodermal region, the tinman- and dpp-dependent "dorsal mesoderm," which is a prerequisite not only for cardiogenesis, but also for visceral mesoderm formation. dipalmitoylphosphatidylserine 266-269 shaggy Drosophila melanogaster 31-34 9621428-5 1998 Here, we present evidence that zw3 has a dual role in mesoderm development: (1) zw3 acts as an antagonist in cardiogenic wg signal transduction, and (2) zw3 also seems to be required to promote positively the formation of a larger mesodermal region, the tinman- and dpp-dependent "dorsal mesoderm," which is a prerequisite not only for cardiogenesis, but also for visceral mesoderm formation. dipalmitoylphosphatidylserine 266-269 shaggy Drosophila melanogaster 80-83 9621428-5 1998 Here, we present evidence that zw3 has a dual role in mesoderm development: (1) zw3 acts as an antagonist in cardiogenic wg signal transduction, and (2) zw3 also seems to be required to promote positively the formation of a larger mesodermal region, the tinman- and dpp-dependent "dorsal mesoderm," which is a prerequisite not only for cardiogenesis, but also for visceral mesoderm formation. dipalmitoylphosphatidylserine 266-269 shaggy Drosophila melanogaster 80-83 9409685-4 1997 By replacing endogenous Hh activity with that of a membrane-tethered form of Hh, we show that Hh acts directly to pattern the central region of the wing, in addition to its role as an inducer of Dpp. dipalmitoylphosphatidylserine 195-198 hedgehog Drosophila melanogaster 24-26 9409685-4 1997 By replacing endogenous Hh activity with that of a membrane-tethered form of Hh, we show that Hh acts directly to pattern the central region of the wing, in addition to its role as an inducer of Dpp. dipalmitoylphosphatidylserine 195-198 hedgehog Drosophila melanogaster 77-79 9409685-4 1997 By replacing endogenous Hh activity with that of a membrane-tethered form of Hh, we show that Hh acts directly to pattern the central region of the wing, in addition to its role as an inducer of Dpp. dipalmitoylphosphatidylserine 195-198 hedgehog Drosophila melanogaster 77-79 9381174-3 1997 In dorsal closure, DFos cooperates with DJun by regulating the expression of dpp; Dpp acts as a relay signal that triggers cell shape changes and DFos expression in neighboring cells. dipalmitoylphosphatidylserine 77-80 decapentaplegic Drosophila melanogaster 82-85 9328280-7 1997 RPE65 also cosedimented with synthetic dipalmitoyl-, 1-palmitoyl, 2-docosahexaenoyl-PC or dipalmitoyl-PS liposomes. dipalmitoylphosphatidylserine 90-104 retinoid isomerohydrolase RPE65 Homo sapiens 0-5 9056781-6 1997 At the level of gene expression, SGG positively regulates dpp expression and negatively regulates wg expression while DSH activity suppresses dpp expression and promotes wg expression. dipalmitoylphosphatidylserine 142-145 dishevelled segment polarity protein 1 pseudogene 1 Homo sapiens 118-121 9275050-1 1997 Although mothers against dpp (MAD) and its related proteins (MADR) are believed to be important components of the cell signaling pathway for the transforming growth factor beta (TGFbeta) superfamily, the presence and regulation of these signaling molecules in ovarian cells by TGFbeta is not known. dipalmitoylphosphatidylserine 25-28 transforming growth factor beta 1 Homo sapiens 145-176 9275050-1 1997 Although mothers against dpp (MAD) and its related proteins (MADR) are believed to be important components of the cell signaling pathway for the transforming growth factor beta (TGFbeta) superfamily, the presence and regulation of these signaling molecules in ovarian cells by TGFbeta is not known. dipalmitoylphosphatidylserine 25-28 transforming growth factor beta 1 Homo sapiens 178-185 9275050-1 1997 Although mothers against dpp (MAD) and its related proteins (MADR) are believed to be important components of the cell signaling pathway for the transforming growth factor beta (TGFbeta) superfamily, the presence and regulation of these signaling molecules in ovarian cells by TGFbeta is not known. dipalmitoylphosphatidylserine 25-28 transforming growth factor beta 1 Homo sapiens 277-284 9226445-4 1997 The effects observed in response to ectopic DPP signaling are also observed upon the tracheal-specific expression of a constitutive active DPP type I receptor (TKV(Q253D)), indicating that the DPP signal is received and transmitted in tracheal cells to control their migration behavior. dipalmitoylphosphatidylserine 44-47 thickveins Drosophila melanogaster 160-163 9226445-4 1997 The effects observed in response to ectopic DPP signaling are also observed upon the tracheal-specific expression of a constitutive active DPP type I receptor (TKV(Q253D)), indicating that the DPP signal is received and transmitted in tracheal cells to control their migration behavior. dipalmitoylphosphatidylserine 139-142 thickveins Drosophila melanogaster 160-163 9226445-5 1997 DPP signaling determines localized gene expression patterns in the developing tracheal placode, and is also required for the dorsal expression of the recently identified BRANCHLESS (BNL) guidance molecule, the ligand of the BREATHLESS (BTL) receptor. dipalmitoylphosphatidylserine 0-3 branchless Drosophila melanogaster 170-180 9136625-2 1997 Molecular and embryological evidence from Xenopus has strongly suggested a similar role for Bmp-4, the dpp homolog, in patterning the dorsal-ventral axis of chordates. dipalmitoylphosphatidylserine 103-106 bone morphogenetic protein 4 L homeolog Xenopus laevis 92-97 9041179-9 1997 This region contains the putative tumor suppressor gene DCC and two Mad (Mothers against dpp)-related genes, DPC4 and MADR2, which are both components in a transforming growth factor-beta-like signaling pathway. dipalmitoylphosphatidylserine 89-92 SMAD family member 4 Homo sapiens 109-113 9041179-9 1997 This region contains the putative tumor suppressor gene DCC and two Mad (Mothers against dpp)-related genes, DPC4 and MADR2, which are both components in a transforming growth factor-beta-like signaling pathway. dipalmitoylphosphatidylserine 89-92 SMAD family member 2 Homo sapiens 118-123 9299558-0 1997 Drosophila MAD, a member of the Smad family, translocates to the nucleus upon stimulation of the dpp pathway. dipalmitoylphosphatidylserine 97-100 Mothers against dpp Drosophila melanogaster 32-36 9244298-2 1997 In Drosophila, HH protein induces the transcription of target genes encoding secondary signals such as DPP and WG proteins by opposing a repressor system. dipalmitoylphosphatidylserine 103-106 hedgehog Drosophila melanogaster 15-17 9224720-4 1997 DJun and Aop regulate dpp expression in the most dorsal row of cells. dipalmitoylphosphatidylserine 22-25 Jun-related antigen Drosophila melanogaster 0-4 9224720-4 1997 DJun and Aop regulate dpp expression in the most dorsal row of cells. dipalmitoylphosphatidylserine 22-25 anterior open Drosophila melanogaster 9-12 9224720-6 1997 Our results provide a causal link between the DJNK and Dpp pathways during dorsal closure. dipalmitoylphosphatidylserine 55-58 basket Drosophila melanogaster 46-50 9056781-7 1997 Sharp borders of gene expression correlating precisely with clone boundaries suggest that the effects of DSH and SGG on transcription of wg and dpp are not mediated by secreted factors but rather act through intracellular effectors. dipalmitoylphosphatidylserine 144-147 dishevelled segment polarity protein 1 pseudogene 1 Homo sapiens 105-108 9079034-14 1997 These data indicate that XBMP-1 may have a role in determining dorso-ventral patterning in Xenopus, but in a different way from the dpp/tolloid system demonstrated in Drosophila. dipalmitoylphosphatidylserine 132-135 bone morphogenetic protein 1 S homeolog Xenopus laevis 25-31 9012523-5 1996 The opposing actions of sog and dpp in the early embryo have been highly conserved during evolution as their vertebrate counterparts, chordin and BMP-4, function homologously to define neural versus non-neural ectoderm in Xenopus. dipalmitoylphosphatidylserine 32-35 chordin, gene 1 S homeolog Xenopus laevis 134-141 9071813-5 1997 Various molecules, including farnesyl transferase-alpha, Mothers against dpp (Mad)-related proteins, and a novel MAPKKK (TAK1), have been suggested to participate in the signal transduction of TGF-beta receptors. dipalmitoylphosphatidylserine 73-76 transforming growth factor beta 1 Homo sapiens 193-201 9006064-5 1997 The transcription factor encoded by spalt major (salm) gene, which is expressed in a broad wedge centered over the dpp stripe, is one target of Dpp signaling. dipalmitoylphosphatidylserine 144-147 spalt major Drosophila melanogaster 36-47 9006064-5 1997 The transcription factor encoded by spalt major (salm) gene, which is expressed in a broad wedge centered over the dpp stripe, is one target of Dpp signaling. dipalmitoylphosphatidylserine 144-147 spalt major Drosophila melanogaster 49-53 9006069-3 1997 Clones of saxophone (sax) or thick veins (tkv) mutant cells, defective in one of the two type I receptors for DPP, show shifts in cell fate along the anterior-posterior axis. dipalmitoylphosphatidylserine 110-113 thickveins Drosophila melanogaster 29-40 9006069-3 1997 Clones of saxophone (sax) or thick veins (tkv) mutant cells, defective in one of the two type I receptors for DPP, show shifts in cell fate along the anterior-posterior axis. dipalmitoylphosphatidylserine 110-113 thickveins Drosophila melanogaster 42-45 9006069-6 1997 The similar effects of sax null and tkv hypomorphic clones indicate that the primary difference in the function of these two receptors during wing patterning is that TKV transmits more of the DPP signal than does SAX. dipalmitoylphosphatidylserine 192-195 thickveins Drosophila melanogaster 166-169 9006079-3 1997 Based on results from epistasis tests with known dorsal/ventral patterning genes, we propose that dCREB-A encodes a transcription factor that functions near the end of both the DPP- and SPI-signaling cascades to translate the corresponding extracellular signals into changes in gene expression. dipalmitoylphosphatidylserine 177-180 Cyclic-AMP response element binding protein A Drosophila melanogaster 98-105 9023056-5 1996 Recent advances, particularly in our understanding of the function of Mothers against dpp-related (MADR) proteins, are providing new insights into how the TGF beta superfamily signals its diverse biological activities. dipalmitoylphosphatidylserine 86-89 transforming growth factor beta 1 Homo sapiens 155-163 9012523-5 1996 The opposing actions of sog and dpp in the early embryo have been highly conserved during evolution as their vertebrate counterparts, chordin and BMP-4, function homologously to define neural versus non-neural ectoderm in Xenopus. dipalmitoylphosphatidylserine 32-35 bone morphogenetic protein 4 L homeolog Xenopus laevis 146-151 9012523-10 1996 The conflicting activities of dpp and sog are also revealed by antagonistic dosage-sensitive interactions between these two genes during vein development. dipalmitoylphosphatidylserine 30-33 short gastrulation Drosophila melanogaster 38-41 9012523-11 1996 Analysis of vein and intervein marker expression in dpp and sog mutant wings suggests that dpp promotes vein fates indirectly by activating the vein gene rhomboid (rho), and that sog functions by blocking an autoactivating Dpp feedback loop. dipalmitoylphosphatidylserine 91-94 short gastrulation Drosophila melanogaster 60-63 9012523-11 1996 Analysis of vein and intervein marker expression in dpp and sog mutant wings suggests that dpp promotes vein fates indirectly by activating the vein gene rhomboid (rho), and that sog functions by blocking an autoactivating Dpp feedback loop. dipalmitoylphosphatidylserine 91-94 decapentaplegic Drosophila melanogaster 223-226 8918894-4 1996 The high levels of Ci activate decapentaplegic (dpp) expression, and, together, Ci and Dpp positively control ara-caup. dipalmitoylphosphatidylserine 87-90 caupolican Drosophila melanogaster 114-118 8957000-7 1996 The defective spreading could be circumvented in htl mutant embryos by providing an ectopic Dpp patterning signal, leading to the formation of heart and dorsal muscle cells. dipalmitoylphosphatidylserine 92-95 heartless Drosophila melanogaster 49-52 8791529-2 1996 In both organisms, the activity of the TGF-beta family member DPP/BMP4 is antagonized by SOG/CHORDIN. dipalmitoylphosphatidylserine 62-65 bone morphogenetic protein 4 L homeolog Xenopus laevis 66-70 8857540-5 1996 Both dpp and wg are required for the nuclear localization of Exd in the endoderm, whereas ectopic expression of dpp and wg expands the domain of nuclear Exd. dipalmitoylphosphatidylserine 5-8 extradenticle Drosophila melanogaster 61-64 8857540-5 1996 Both dpp and wg are required for the nuclear localization of Exd in the endoderm, whereas ectopic expression of dpp and wg expands the domain of nuclear Exd. dipalmitoylphosphatidylserine 112-115 extradenticle Drosophila melanogaster 153-156 8791529-2 1996 In both organisms, the activity of the TGF-beta family member DPP/BMP4 is antagonized by SOG/CHORDIN. dipalmitoylphosphatidylserine 62-65 chordin, gene 1 S homeolog Xenopus laevis 93-100 8903352-2 1996 Adjacent, more anterior cells in the morphogenetic furrow respond to Hh by expressing decapentaplegic (dpp), suggesting that the relationship between Hh and Dpp might be similar to that in the limb imaginal discs where Dpp mediates the organizing activity of Hh. dipalmitoylphosphatidylserine 157-160 hedgehog Drosophila melanogaster 69-71 8903352-2 1996 Adjacent, more anterior cells in the morphogenetic furrow respond to Hh by expressing decapentaplegic (dpp), suggesting that the relationship between Hh and Dpp might be similar to that in the limb imaginal discs where Dpp mediates the organizing activity of Hh. dipalmitoylphosphatidylserine 157-160 decapentaplegic Drosophila melanogaster 103-106 8903352-2 1996 Adjacent, more anterior cells in the morphogenetic furrow respond to Hh by expressing decapentaplegic (dpp), suggesting that the relationship between Hh and Dpp might be similar to that in the limb imaginal discs where Dpp mediates the organizing activity of Hh. dipalmitoylphosphatidylserine 219-222 hedgehog Drosophila melanogaster 69-71 8681796-0 1996 Mad acts downstream of Dpp receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye. dipalmitoylphosphatidylserine 79-82 Mothers against dpp Drosophila melanogaster 0-3 8681796-0 1996 Mad acts downstream of Dpp receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye. dipalmitoylphosphatidylserine 79-82 decapentaplegic Drosophila melanogaster 23-26 8681796-2 1996 We show that the Mothers against dpp (Mad) gene is required for dpp signaling during eye development. dipalmitoylphosphatidylserine 33-36 Mothers against dpp Drosophila melanogaster 38-41 8681796-4 1996 Mad-mediated dpp signaling is absolutely required for the initiation of the morphogenetic furrow in the eye, but has only a minor role in its subsequent propagation across the eye disc. dipalmitoylphosphatidylserine 13-16 Mothers against dpp Drosophila melanogaster 0-3 7488098-1 1995 BRK-3 is a vertebrate type II receptor for BMP-4 distantly related to invertebrate type II receptors for BMP-2/BMP-4/dpp, such as daf-4 and punt. dipalmitoylphosphatidylserine 117-120 bone morphogenetic protein receptor type II S homeolog Xenopus laevis 0-5 7488098-1 1995 BRK-3 is a vertebrate type II receptor for BMP-4 distantly related to invertebrate type II receptors for BMP-2/BMP-4/dpp, such as daf-4 and punt. dipalmitoylphosphatidylserine 117-120 bone morphogenetic protein 2 S homeolog Xenopus laevis 105-110 7750652-9 1995 We suggest that BMP-4 may have an analogous role to the Drosophila gene, dpp, in dorsal/ventral pattern formation. dipalmitoylphosphatidylserine 73-76 bone morphogenetic protein 4 L homeolog Xenopus laevis 16-21 7780144-3 1995 Based on these and other evidences, we propose that the mechanism by which CD26 regulates proliferation is associated with its DPP activity. dipalmitoylphosphatidylserine 127-130 dipeptidylpeptidase 4 Rattus norvegicus 75-79 7774018-0 1995 Schnurri is required for Drosophila Dpp signaling and encodes a zinc finger protein similar to the mammalian transcription factor PRDII-BF1. dipalmitoylphosphatidylserine 36-39 schnurri Drosophila melanogaster 0-8 7774018-0 1995 Schnurri is required for Drosophila Dpp signaling and encodes a zinc finger protein similar to the mammalian transcription factor PRDII-BF1. dipalmitoylphosphatidylserine 36-39 HIVEP zinc finger 1 Homo sapiens 130-139 7702589-3 1995 dpp signaling in other developmental processes again requires both tkv and sax, but to differing degrees. dipalmitoylphosphatidylserine 0-3 thickveins Drosophila melanogaster 67-70 33763471-5 2021 In current study, an in silico approach was used to evaluate the interactions and binding patterns of plant-derived peptides devised from a hypoglycemic protein adMc1 of M. charantia as potential inhibitor of DPP-IV, SGLT1, and GLUT2 receptor proteins. dipalmitoylphosphatidylserine 209-212 2S albumin-like Momordica charantia 161-166 7958919-4 1994 Genetic evidence indicates that sog functions to antagonize dpp activity. dipalmitoylphosphatidylserine 60-63 short gastrulation Drosophila melanogaster 32-35 7958919-6 1994 sog is expressed in a broad lateral stripe of cells that abuts the dorsal territory of dpp-expressing cells. dipalmitoylphosphatidylserine 87-90 short gastrulation Drosophila melanogaster 0-3 7958919-9 1994 These putative soluble Sog peptides may then diffuse into the dorsal region to antagonize the activity of Dpp, leading to the subdivision of the dorsal territory into amnioserosa and dorsal ectoderm. dipalmitoylphosphatidylserine 106-109 short gastrulation Drosophila melanogaster 23-26 8134837-2 1994 Transduction of the DPP signal was investigated by cloning of serine-threonine kinase transmembrane receptors from Drosophila because this type of receptor is specific for the TGF-beta-like ligands. dipalmitoylphosphatidylserine 20-23 decapentaplegic Drosophila melanogaster 176-184 8142425-8 1994 Furthermore, the transition of the DPPS/Ca2+ complex observed by DSC at 155 degrees C was perturbed by the presence of 1,2-DPG, indicating a change in the structure of the crystalline complex. dipalmitoylphosphatidylserine 35-39 carbonic anhydrase 2 Homo sapiens 40-43 8044838-2 1994 Brk25D binds dpp protein and bone morphogenetic protein 2 with high affinity. dipalmitoylphosphatidylserine 13-16 thickveins Drosophila melanogaster 0-6 8044838-3 1994 Mutations affecting Brk25D map to the gene thick veins and block the expression of two decapentaplegic-responsive (dpp-responsive) genes, dpp and labial, in the embryonic midgut. dipalmitoylphosphatidylserine 115-118 thickveins Drosophila melanogaster 20-26 8044838-3 1994 Mutations affecting Brk25D map to the gene thick veins and block the expression of two decapentaplegic-responsive (dpp-responsive) genes, dpp and labial, in the embryonic midgut. dipalmitoylphosphatidylserine 138-141 thickveins Drosophila melanogaster 20-26 8044838-5 1994 Brk43E is the product of the gene saxophone, which also interacts with dpp. dipalmitoylphosphatidylserine 71-74 saxophone Drosophila melanogaster 0-6 8044838-6 1994 We conclude that dpp signaling in vivo is mediated by at least two receptors, Brk25D and Brk43E. dipalmitoylphosphatidylserine 17-20 thickveins Drosophila melanogaster 78-84 8044838-6 1994 We conclude that dpp signaling in vivo is mediated by at least two receptors, Brk25D and Brk43E. dipalmitoylphosphatidylserine 17-20 saxophone Drosophila melanogaster 89-95 8044839-6 1994 Some, but not all, of the tkv expression pattern parallels that of dpp. dipalmitoylphosphatidylserine 67-70 thickveins Drosophila melanogaster 26-29 34401649-10 2021 Conclusion: DPP can increase the expressions of NRF2, GPX4, SOD2, and CAT genes and also improve the semen quality in infertile men. dipalmitoylphosphatidylserine 12-15 superoxide dismutase 2 Homo sapiens 60-64 34875394-2 2022 The Hh signaling directly activates the expression of dpp through the transcription factor cubitus interruptus (Ci). dipalmitoylphosphatidylserine 54-57 hedgehog Drosophila melanogaster 4-6 34875394-2 2022 The Hh signaling directly activates the expression of dpp through the transcription factor cubitus interruptus (Ci). dipalmitoylphosphatidylserine 54-57 cubitus interruptus Drosophila melanogaster 91-110 34265108-2 2021 Autoantibodies targeting epitopes on the processed BP180, 120-kDa (LAD-1), and 97-kDa (LABD97) linear immunoglobulin (Ig)A dermatosis antigens are the major autoantibodies in DPP-4i-associated BP. dipalmitoylphosphatidylserine 175-178 collagen type XVII alpha 1 chain Homo sapiens 51-56 34265108-2 2021 Autoantibodies targeting epitopes on the processed BP180, 120-kDa (LAD-1), and 97-kDa (LABD97) linear immunoglobulin (Ig)A dermatosis antigens are the major autoantibodies in DPP-4i-associated BP. dipalmitoylphosphatidylserine 175-178 ladinin 1 Homo sapiens 67-72 34830394-6 2021 A specific inhibitor of AKR1C1 (5PBSA) and AKR1C3 (ASP9521) was used to enhance cisplatin-induced KATO/DPP cell death. dipalmitoylphosphatidylserine 103-106 aldo-keto reductase family 1 member C1 Homo sapiens 24-30 34830394-6 2021 A specific inhibitor of AKR1C1 (5PBSA) and AKR1C3 (ASP9521) was used to enhance cisplatin-induced KATO/DPP cell death. dipalmitoylphosphatidylserine 103-106 aldo-keto reductase family 1 member C3 Homo sapiens 43-49 34401649-7 2021 Results: The mRNA expression levels of NRF2, SOD2, GPX4, and CAT (p < 0.05 for all) and significantly increased after treatment with DPP. dipalmitoylphosphatidylserine 133-136 NFE2 like bZIP transcription factor 2 Homo sapiens 39-43 34401649-7 2021 Results: The mRNA expression levels of NRF2, SOD2, GPX4, and CAT (p < 0.05 for all) and significantly increased after treatment with DPP. dipalmitoylphosphatidylserine 133-136 superoxide dismutase 2 Homo sapiens 45-49 34401649-10 2021 Conclusion: DPP can increase the expressions of NRF2, GPX4, SOD2, and CAT genes and also improve the semen quality in infertile men. dipalmitoylphosphatidylserine 12-15 catalase Homo sapiens 70-73 35443381-13 2022 OBSERVATION: Serum adiponectin levels in dpp group was higher at end of third month as compared to 0 month (45.9 +/- 5.9 vs. 39.8 +/- 4.1 mcg/dl; p<0.05). dipalmitoylphosphatidylserine 41-44 adiponectin, C1Q and collagen domain containing Homo sapiens 19-30 34401649-7 2021 Results: The mRNA expression levels of NRF2, SOD2, GPX4, and CAT (p < 0.05 for all) and significantly increased after treatment with DPP. dipalmitoylphosphatidylserine 133-136 glutathione peroxidase 4 Homo sapiens 51-55 34401649-7 2021 Results: The mRNA expression levels of NRF2, SOD2, GPX4, and CAT (p < 0.05 for all) and significantly increased after treatment with DPP. dipalmitoylphosphatidylserine 133-136 catalase Homo sapiens 61-64 34401649-10 2021 Conclusion: DPP can increase the expressions of NRF2, GPX4, SOD2, and CAT genes and also improve the semen quality in infertile men. dipalmitoylphosphatidylserine 12-15 NFE2 like bZIP transcription factor 2 Homo sapiens 48-52 34401649-10 2021 Conclusion: DPP can increase the expressions of NRF2, GPX4, SOD2, and CAT genes and also improve the semen quality in infertile men. dipalmitoylphosphatidylserine 12-15 glutathione peroxidase 4 Homo sapiens 54-58 34275129-12 2021 However, DPP Ser-Asp/Asp-Ser repeat regions bind to calcium-phosphate deposits and promote hydroxyapatite crystal growth and mineralisation via calmodulin-dependent protein kinase II (CaMKII) cascades. dipalmitoylphosphatidylserine 9-12 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 144-182 34275129-12 2021 However, DPP Ser-Asp/Asp-Ser repeat regions bind to calcium-phosphate deposits and promote hydroxyapatite crystal growth and mineralisation via calmodulin-dependent protein kinase II (CaMKII) cascades. dipalmitoylphosphatidylserine 9-12 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 184-190 34149174-14 2021 LINC00665 silencing could overcome DPP-resistance of GC cells by downregulating GRP78 via sponging miR-379-5p, indicating that LINC00665 might be a potential therapeutic target for DDP- resistant GC patients. dipalmitoylphosphatidylserine 35-38 long intergenic non-protein coding RNA 665 Homo sapiens 0-9 34149174-14 2021 LINC00665 silencing could overcome DPP-resistance of GC cells by downregulating GRP78 via sponging miR-379-5p, indicating that LINC00665 might be a potential therapeutic target for DDP- resistant GC patients. dipalmitoylphosphatidylserine 35-38 heat shock protein family A (Hsp70) member 5 Homo sapiens 80-85 34149174-14 2021 LINC00665 silencing could overcome DPP-resistance of GC cells by downregulating GRP78 via sponging miR-379-5p, indicating that LINC00665 might be a potential therapeutic target for DDP- resistant GC patients. dipalmitoylphosphatidylserine 35-38 long intergenic non-protein coding RNA 665 Homo sapiens 127-136 35352361-1 2022 An in silico approach was used for hydrolysis of sheep milk proteins (alpha-s1, alpha-s2, beta-casein, kappa-Cn, alpha-lactalbumin, and beta-lactoglobulin) by gastrointestinal enzymes in order to generate bioactive peptides (BAPs) that can inhibit ACE and DPP-IV. dipalmitoylphosphatidylserine 256-259 alpha-lactalbumin Ovis aries 113-130 35352361-1 2022 An in silico approach was used for hydrolysis of sheep milk proteins (alpha-s1, alpha-s2, beta-casein, kappa-Cn, alpha-lactalbumin, and beta-lactoglobulin) by gastrointestinal enzymes in order to generate bioactive peptides (BAPs) that can inhibit ACE and DPP-IV. dipalmitoylphosphatidylserine 256-259 beta-lactoglobulin-1/B Ovis aries 136-154 35352361-1 2022 An in silico approach was used for hydrolysis of sheep milk proteins (alpha-s1, alpha-s2, beta-casein, kappa-Cn, alpha-lactalbumin, and beta-lactoglobulin) by gastrointestinal enzymes in order to generate bioactive peptides (BAPs) that can inhibit ACE and DPP-IV. dipalmitoylphosphatidylserine 256-259 angiotensin-converting enzyme Ovis aries 248-251 35060938-1 2022 INTRODUCTION: Dipeptidyl peptidase (DPP)-4 is part of a larger family of proteases referred to as DPPs. dipalmitoylphosphatidylserine 98-102 dipeptidyl peptidase 4 Homo sapiens 14-42