PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
20641386-9	2004	(5) conjugated hydrazinonicotinamide (HYNIC) and galactose (via lactobionic acid) to deacetylate chitosan for radiolabeling with (99m)Tc to form (99m)Tc-HYNIC-galactosyl-chitosan ((99m)Tc-HGC) for imaging ASGP-R expression in the liver.	hydrazino nicotinamide	15-36	asialoglycoprotein receptor 1	Homo sapiens	205-211
19123983-1	2008	The aim of this study was to evaluate whether technetium 99m hydrazinonicotinamide (99mTc-HYNIC)-annexin V single-photon emission computed tomography (SPECT) would detect dose-dependent doxorubicin (DOX)-mediated cell death in the heart compared with functional echocardiography.	hydrazino nicotinamide	61-82	annexin A5	Rattus norvegicus	97-106
19289435-1	2009	UNLABELLED: The aim of this study was to determine the effects of assisted coordination by amino acids such as histidine and glutamic acid on the function of (99m)Tc-labeled gastrin peptide-hydrazinonicotinamide (HYNIC) conjugates and their ability to target cholecystokinin-R in small-animal models.	hydrazino nicotinamide	190-211	gastrin	Mus musculus	174-181
20641933-0	2004	(99m)Tc-Nicotinic acid/tricine/hydrazinonicotinamide-nonsulfated cholecystokinin-8 (99m)Tc-Nicotinic acid/tricine/hydrazinonicotinamide-nonsulfated cholecystokinin-8 ((99m)Tc-NA/tricine/HYNIC-nsCCK-8) is a radiolabeled peptide developed for single-photon emission computed tomography (SPECT) imaging of tumors that express the gastrin/cholecystokinin-2 (CCK-2) receptor (1).	hydrazino nicotinamide	31-52	gastrin	Homo sapiens	327-334
20641671-7	2004	Annexin V has been radiolabeled with (123)I, (125)I, and (99m)Tc for single-photon emission computed tomography (SPECT) imaging (9, 10), and hydrazinonicotinamide (HYNIC) has been conjugated to human recombinant annexin V to form HYNIC-annexin V (11).	hydrazino nicotinamide	141-162	annexin A5	Homo sapiens	0-9
20641934-12	2004	(12) successfully labeled recombinant human MCP-1 with (99m)Tc using the nicotinic acid analog hydrazinonicotinamide (HYNIC) as the chelator.	hydrazino nicotinamide	95-116	C-C motif chemokine ligand 2	Homo sapiens	44-49
18090214-5	2007	Annexin V was labelled with 99mTc by hydrazinonicotinamide (HYNIC).	hydrazino nicotinamide	37-58	annexin A5	Rattus norvegicus	0-9
20641933-0	2004	(99m)Tc-Nicotinic acid/tricine/hydrazinonicotinamide-nonsulfated cholecystokinin-8 (99m)Tc-Nicotinic acid/tricine/hydrazinonicotinamide-nonsulfated cholecystokinin-8 ((99m)Tc-NA/tricine/HYNIC-nsCCK-8) is a radiolabeled peptide developed for single-photon emission computed tomography (SPECT) imaging of tumors that express the gastrin/cholecystokinin-2 (CCK-2) receptor (1).	hydrazino nicotinamide	31-52	cholecystokinin B receptor	Homo sapiens	354-369
20641933-0	2004	(99m)Tc-Nicotinic acid/tricine/hydrazinonicotinamide-nonsulfated cholecystokinin-8 (99m)Tc-Nicotinic acid/tricine/hydrazinonicotinamide-nonsulfated cholecystokinin-8 ((99m)Tc-NA/tricine/HYNIC-nsCCK-8) is a radiolabeled peptide developed for single-photon emission computed tomography (SPECT) imaging of tumors that express the gastrin/cholecystokinin-2 (CCK-2) receptor (1).	hydrazino nicotinamide	114-135	gastrin	Homo sapiens	327-334
20641933-0	2004	(99m)Tc-Nicotinic acid/tricine/hydrazinonicotinamide-nonsulfated cholecystokinin-8 (99m)Tc-Nicotinic acid/tricine/hydrazinonicotinamide-nonsulfated cholecystokinin-8 ((99m)Tc-NA/tricine/HYNIC-nsCCK-8) is a radiolabeled peptide developed for single-photon emission computed tomography (SPECT) imaging of tumors that express the gastrin/cholecystokinin-2 (CCK-2) receptor (1).	hydrazino nicotinamide	114-135	cholecystokinin B receptor	Homo sapiens	354-369
15585485-3	2004	METHODS: Hydrazinonicotinamide (HYNIC)-annexin V was labeled with (99m)Tc ((99m)Tc-annexin V).	hydrazino nicotinamide	9-30	annexin A5	Rattus norvegicus	39-48
17079815-0	2006	Sequential 99mTc-hydrazinonicotinamide-annexin V imaging for predicting response to chemotherapy.	hydrazino nicotinamide	16-38	annexin A5	Homo sapiens	39-48
16649535-0	2006	New tacrine-hydrazinonicotinamide hybrids as acetylcholinesterase inhibitors of potential interest for the early diagnostics of Alzheimer"s disease.	hydrazino nicotinamide	12-33	acetylcholinesterase (Cartwright blood group)	Homo sapiens	45-65
16649535-1	2006	The syntheses and the preliminary results of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition by an affinity series of tacrine-hydrazinonicotinamide hybrids are described.	hydrazino nicotinamide	150-171	acetylcholinesterase (Cartwright blood group)	Homo sapiens	45-65
16649535-1	2006	The syntheses and the preliminary results of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition by an affinity series of tacrine-hydrazinonicotinamide hybrids are described.	hydrazino nicotinamide	150-171	acetylcholinesterase (Cartwright blood group)	Homo sapiens	67-71
16649535-1	2006	The syntheses and the preliminary results of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition by an affinity series of tacrine-hydrazinonicotinamide hybrids are described.	hydrazino nicotinamide	150-171	butyrylcholinesterase	Homo sapiens	77-98
16649535-1	2006	The syntheses and the preliminary results of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition by an affinity series of tacrine-hydrazinonicotinamide hybrids are described.	hydrazino nicotinamide	150-171	butyrylcholinesterase	Homo sapiens	100-104
20641932-0	2004	(99m)Tc-Nicotinic acid/tricine/hydrazinonicotinamide-sulfated cholecystokinin-8 (99m)Tc-Nicotinic acid/tricine/hydrazinonicotinamide-sulfated cholecystokinin-8 ((99m)Tc-NA/tricine/HYNIC-sCCK-8) is a radiolabeled peptide developed for single-photon emission computed tomography (SPECT) imaging of tumors that express the gastrin/cholecystokinin-2 (CCK-2) receptor (1).	hydrazino nicotinamide	31-52	gastrin	Homo sapiens	320-327
20641932-0	2004	(99m)Tc-Nicotinic acid/tricine/hydrazinonicotinamide-sulfated cholecystokinin-8 (99m)Tc-Nicotinic acid/tricine/hydrazinonicotinamide-sulfated cholecystokinin-8 ((99m)Tc-NA/tricine/HYNIC-sCCK-8) is a radiolabeled peptide developed for single-photon emission computed tomography (SPECT) imaging of tumors that express the gastrin/cholecystokinin-2 (CCK-2) receptor (1).	hydrazino nicotinamide	31-52	cholecystokinin B receptor	Homo sapiens	347-362
16311643-9	2005	The corresponding hydrazinonicotinamide derivative N-[5-(6"-hydrazinopyridine-3"-carbonyl)aminopentyl]maleimide (L10) was also prepared.	hydrazino nicotinamide	18-39	ribosomal protein L10	Homo sapiens	113-116
15872355-7	2005	Wild-type annexin V was also labeled with (99m)Tc after derivatization with hydrazinonicotinamide (HYNIC).	hydrazino nicotinamide	76-97	annexin A5	Mus musculus	10-19
15596698-4	2004	A derivative of hydrazinonicotinamide was used as bifunctional coupling agent to label IL-8 with (99m)Tc.	hydrazino nicotinamide	16-37	interleukin-8	Oryctolagus cuniculus	87-91
15585485-3	2004	METHODS: Hydrazinonicotinamide (HYNIC)-annexin V was labeled with (99m)Tc ((99m)Tc-annexin V).	hydrazino nicotinamide	9-30	annexin A5	Rattus norvegicus	83-92
12699393-3	2003	To realize the advantages of this approach, a lysine-hynic conjugate Fmoc-N-epsilon-(Hynic-Boc)-Lys was synthesized for incorporating the well-known technetium-99m-binding hydrazinonicotinamide ligand into peptides during SPPS.	hydrazino nicotinamide	172-193	BOC cell adhesion associated, oncogene regulated	Homo sapiens	91-94
15235069-5	2004	Here, NAP-2 and its C-terminal shortened variants NAP-2(1-68), NAP-2(1-66), and NAP-2(1-63) were labeled with (99m)Tc via the hydrazinonicotinamide (HYNIC) chelator and their potential for imaging of infection was investigated in a rabbit model of infection.	hydrazino nicotinamide	126-147	pro-platelet basic protein	Homo sapiens	6-11
11459468-0	2001	99mTc-labeling of a hydrazinonicotinamide-conjugated vitronectin receptor antagonist useful for imaging tumors.	hydrazino nicotinamide	20-41	vitronectin	Homo sapiens	53-64
11906276-1	2002	In our previous studies, interleukin-8 (IL-8) was labeled with (99m)Tc using hydrazinonicotinamide (HYNIC) as bifunctional coupling agent and tricine as coligand.	hydrazino nicotinamide	77-98	C-X-C motif chemokine ligand 8	Homo sapiens	25-38
11906276-1	2002	In our previous studies, interleukin-8 (IL-8) was labeled with (99m)Tc using hydrazinonicotinamide (HYNIC) as bifunctional coupling agent and tricine as coligand.	hydrazino nicotinamide	77-98	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
33048944-7	2020	In the present study, we designed a probe using Polyamidoamine (PAMAM) fifth-generation (G5) dendrimers conjugated with mannose, Cyanine 7 (Cy7), and hydrazinonicotinamide (HYNIC) for target macrophages with high expression of MRC1 in the tumor.	hydrazino nicotinamide	150-171	mannose receptor C-type 1	Homo sapiens	227-231
11390557-3	2001	In this study, the potential of interleukin-8 (IL-8) labeled with (99m)Tc using hydrazinonicotinamide (HYNIC) to image IBD was investigated in a rabbit model of acute colitis and compared with that of (99m)Tc-HMPAO-labeled granulocytes.	hydrazino nicotinamide	80-101	interleukin-8	Oryctolagus cuniculus	32-45
11390557-3	2001	In this study, the potential of interleukin-8 (IL-8) labeled with (99m)Tc using hydrazinonicotinamide (HYNIC) to image IBD was investigated in a rabbit model of acute colitis and compared with that of (99m)Tc-HMPAO-labeled granulocytes.	hydrazino nicotinamide	80-101	interleukin-8	Oryctolagus cuniculus	47-51
9935075-8	1999	METHODS: Annexin V was coupled to hydrazinonicotinamide (HYNIC) and radiolabeled with 99mTc.	hydrazino nicotinamide	34-55	annexin A5	Homo sapiens	9-18
9600968-4	1998	After derivatization with hydrazinonicotinamide, annexin V was radiolabeled with technetium 99m.	hydrazino nicotinamide	26-47	annexin A5	Mus musculus	49-58
9600968-5	1998	In vivo localization of technetium 99m hydrazinonicotinamide-annexin V was tested in three models: fuminant hepatic apoptosis induced by anti-Fas antibody injection in BALB/c mice; acute rejection in ACI rats with transplanted heterotopic PVG cardiac allografts; and cyclophosphamide treatment of transplanted 38C13 murine B cell lymphomas.	hydrazino nicotinamide	39-60	annexin A5	Mus musculus	61-70
11197959-4	2001	In this study IL-8 was labeled with 99mTc through the hydrazinonicotinamide (HYNIC) chelator.	hydrazino nicotinamide	54-75	interleukin-8	Oryctolagus cuniculus	14-18
10587107-4	1999	To label 3F8 with 99mTc, the antibody was first coupled with a heterobifunctional linker, succinimidyl-6-hydrazinonicotinate hydrochloride (SHNH), obtaining a hydrazinonicotinamide-antibody conjugate.	hydrazino nicotinamide	159-180	retinoic acid induced 2	Mus musculus	9-12
24098950-2	2014	In this study, for the imaging of HER2-related tumours, a modified RNA aptamer with HER2-specific targeting was labelled with (99m)Tc, by using hydrazino nicotinamide (HYNIC) as the chelator in the presence of tricine or ethylenediamine-N,N"-diacetic acid (EDDA) as the co-ligand.	hydrazino nicotinamide	144-166	erb-b2 receptor tyrosine kinase 2	Homo sapiens	34-38
31040674-7	2019	The radiolabeled NPs showed insignificant toxicity (>74% cell viability) and high affinity (IC50=8.79 microg/mL) for the gastrin-releasing peptide (GRP)-avid BC T-47D cells using competitive binding assay against 99mTc-hydrazinonicotinamide (HYNIC)-gamma-aminobutyric acid (GABA)-BN (7-14).	hydrazino nicotinamide	222-243	gastrin releasing peptide	Homo sapiens	124-149
31040674-7	2019	The radiolabeled NPs showed insignificant toxicity (>74% cell viability) and high affinity (IC50=8.79 microg/mL) for the gastrin-releasing peptide (GRP)-avid BC T-47D cells using competitive binding assay against 99mTc-hydrazinonicotinamide (HYNIC)-gamma-aminobutyric acid (GABA)-BN (7-14).	hydrazino nicotinamide	222-243	gastrin releasing peptide	Homo sapiens	151-154
28104744-5	2017	Methods: The HER2-targeted peptide H6F (YLFFVFER) was conjugated with the bifunctional chelator hydrazinonicotinamide (HYNIC).	hydrazino nicotinamide	96-117	erb-b2 receptor tyrosine kinase 2	Homo sapiens	13-17
26452556-3	2016	PROCEDURES: CXCR4 siRNAs were radiolabeled with (99m)Tc using the bifunctional chelator hydrazinonicotinamide (HYNIC), and the labeling efficiency, specific activity and radiochemical purity were determined.	hydrazino nicotinamide	88-109	C-X-C motif chemokine receptor 4	Homo sapiens	12-17
25175799-2	2015	In this work, a lactam bridgecyclized alpha-MSH analog was labeled with (99m) via the hydrazinonicotinamide (HYNIC) chelator and characterized for its melanoma tumor targeting properties.	hydrazino nicotinamide	86-107	pro-opiomelanocortin-alpha	Mus musculus	38-47
24098950-2	2014	In this study, for the imaging of HER2-related tumours, a modified RNA aptamer with HER2-specific targeting was labelled with (99m)Tc, by using hydrazino nicotinamide (HYNIC) as the chelator in the presence of tricine or ethylenediamine-N,N"-diacetic acid (EDDA) as the co-ligand.	hydrazino nicotinamide	144-166	erb-b2 receptor tyrosine kinase 2	Homo sapiens	84-88
25431156-1	2014	Hydrazinonicotinamide-annexin A5 (HYNIC-Anx), a 99m technetium (99mTc)-labeled agent targeting phosphatidylserine, proved to be sensitive for the detection of apoptosis and thrombosis but is no longer available for clinical use.	hydrazino nicotinamide	0-21	annexin A5	Homo sapiens	22-32
20870154-0	2010	Investigation of 99mTc-labelling of recombinant human interleukin-2 via hydrazinonicotinamide.	hydrazino nicotinamide	72-93	interleukin 2	Homo sapiens	54-67
20870154-3	2010	The aim of present study was to develop an efficient procedure of (99m)Tc-labelling of recombinant human interleukin-2 (rhIL-2) via hydrazinonicotinamide (HYNIC) to develop a dry kit formulation.	hydrazino nicotinamide	132-153	interleukin 2	Homo sapiens	105-118