PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 21336971-10 2011 In addition, specific inhibitor of caspase-12 (Z-ATAD-FMK) and caspase-9 (Z-LEHD-FMK) partly suppressed cyclic stretch-induced AF cell apoptosis and the anti-apoptotic effects of the caspase inhibitors were additive. z-atad-fmk 47-57 caspase 12 Rattus norvegicus 35-45 21336971-10 2011 In addition, specific inhibitor of caspase-12 (Z-ATAD-FMK) and caspase-9 (Z-LEHD-FMK) partly suppressed cyclic stretch-induced AF cell apoptosis and the anti-apoptotic effects of the caspase inhibitors were additive. z-atad-fmk 47-57 caspase 8 Rattus norvegicus 35-42 18280615-6 2008 Pretreatment with z-ATAD-fmk, a cell-permeable caspase-12-selective inhibitor significantly attenuated the TM-induced increase of PI fluorescence in the CA1 and DG subregion but not in area CA3. z-atad-fmk 18-28 carbonic anhydrase 1 Rattus norvegicus 153-156 19960285-6 2010 Finally, NS3694 and Z-ATAD-FMK were employed to inhibit the formation of apoptosome complex and the activation of caspase-12, respectively, and apoptotic incidence and caspase-9 activity were assayed. z-atad-fmk 20-30 caspase 12 Rattus norvegicus 114-124 19960285-9 2010 Furthermore, NS3694 and Z-ATAD-FMK dramatically suppress annular cell apoptosis and caspase-9 activity. z-atad-fmk 24-34 caspase 9 Rattus norvegicus 84-93 18505440-5 2008 In the presence of 50 micromol/L Z-ATAD-FMK (a caspase 12 inhibitor) and 100 micromol/L Z-LEHD-FMK (a caspase 9 inhibitor), the CTX III-mediated activation of caspase 9 and caspase 3 was significantly reduced. z-atad-fmk 33-43 caspase 9 Homo sapiens 159-168 18505440-5 2008 In the presence of 50 micromol/L Z-ATAD-FMK (a caspase 12 inhibitor) and 100 micromol/L Z-LEHD-FMK (a caspase 9 inhibitor), the CTX III-mediated activation of caspase 9 and caspase 3 was significantly reduced. z-atad-fmk 33-43 caspase 3 Homo sapiens 173-182 18068200-7 2008 However, pre-treatment with z-ATAD-fmk, a caspase-12 inhibitor, followed by 7kCh exposure lead to significantly increased caspase-8 activity. z-atad-fmk 28-38 caspase 8 Homo sapiens 122-131 16338971-9 2006 The functional importance of caspase-12 activation was supported by the use of Z-ATAD-FMK, which reduced the NE-induced processing of caspase-12 and cell apoptosis, but the caspase-12, -9, and -3 inhibitors had no effects on the increase in cytosolic cytochrome c produced by NE. z-atad-fmk 79-89 caspase 12 Rattus norvegicus 29-39 16338971-9 2006 The functional importance of caspase-12 activation was supported by the use of Z-ATAD-FMK, which reduced the NE-induced processing of caspase-12 and cell apoptosis, but the caspase-12, -9, and -3 inhibitors had no effects on the increase in cytosolic cytochrome c produced by NE. z-atad-fmk 79-89 caspase 12 Rattus norvegicus 134-144 26998625-4 2016 Z-ATAD-FMK was used to inhibit caspase-12 activity. z-atad-fmk 0-10 caspase 12 Mus musculus 31-41 32788872-6 2020 Interestingly, pretreatment with the caspase-12-specific inhibitor Z-ATAD-FMK attenuated cell injury and apoptosis and decreased the levels of NLRP3, caspase-1, IL-1beta, and cleaved caspase-3 in the OGD group. z-atad-fmk 67-77 caspase 12 Mus musculus 37-47 32788872-6 2020 Interestingly, pretreatment with the caspase-12-specific inhibitor Z-ATAD-FMK attenuated cell injury and apoptosis and decreased the levels of NLRP3, caspase-1, IL-1beta, and cleaved caspase-3 in the OGD group. z-atad-fmk 67-77 NLR family, pyrin domain containing 3 Mus musculus 143-148 32788872-6 2020 Interestingly, pretreatment with the caspase-12-specific inhibitor Z-ATAD-FMK attenuated cell injury and apoptosis and decreased the levels of NLRP3, caspase-1, IL-1beta, and cleaved caspase-3 in the OGD group. z-atad-fmk 67-77 caspase 1 Mus musculus 37-46 32788872-6 2020 Interestingly, pretreatment with the caspase-12-specific inhibitor Z-ATAD-FMK attenuated cell injury and apoptosis and decreased the levels of NLRP3, caspase-1, IL-1beta, and cleaved caspase-3 in the OGD group. z-atad-fmk 67-77 interleukin 1 alpha Mus musculus 161-169 32788872-6 2020 Interestingly, pretreatment with the caspase-12-specific inhibitor Z-ATAD-FMK attenuated cell injury and apoptosis and decreased the levels of NLRP3, caspase-1, IL-1beta, and cleaved caspase-3 in the OGD group. z-atad-fmk 67-77 caspase 3 Mus musculus 183-192 30605698-8 2019 In addition, Z-ATAD-FMK (a caspase-12 inhibitor) counteracted the Cd-induced activation of caspase-12 and -3, and apoptosis. z-atad-fmk 13-23 caspase 12 Rattus norvegicus 27-37 30605698-8 2019 In addition, Z-ATAD-FMK (a caspase-12 inhibitor) counteracted the Cd-induced activation of caspase-12 and -3, and apoptosis. z-atad-fmk 13-23 caspase 12 Rattus norvegicus 91-108 28825094-12 2017 TP-induced cardiomyocyte apoptosis was virtually abolished by Z-ATAD-FMK (a caspase-12 specific inhibitor). z-atad-fmk 62-72 caspase 12 Rattus norvegicus 76-86 27847321-7 2017 Contrarily, salubrinal (the ER stress inhibitor), z-ATAD-fmk (the caspase-12 inhibitor) or CHOP shRNAs significantly attenuated AICAR-induced gallbladder cancer cell apoptosis. z-atad-fmk 50-60 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Homo sapiens 128-133 25649541-8 2015 After the pretreatment of Z-ATAD-FMK, an inhibitor of caspase-12, the apoptosis level of the C17.2 cells co-cultured with TgCtwh3 or RH tachyzoites had an apparent decline, and correspondingly, the expression levels of those related proteins were notably decreased. z-atad-fmk 26-36 caspase 12 Mus musculus 54-64 25226445-4 2015 To explore the underlying mechanism, Z-ATAD-FMK (a selective caspase-12 inhibitor) was used to identify the key molecule involved. z-atad-fmk 37-47 caspase 12 Rattus norvegicus 61-71