PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
25649541-8	2015	After the pretreatment of Z-ATAD-FMK, an inhibitor of caspase-12, the apoptosis level of the C17.2 cells co-cultured with TgCtwh3 or RH tachyzoites had an apparent decline, and correspondingly, the expression levels of those related proteins were notably decreased.	z-atad-fmk	26-36	caspase 12	Mus musculus	54-64
28825094-12	2017	TP-induced cardiomyocyte apoptosis was virtually abolished by Z-ATAD-FMK (a caspase-12 specific inhibitor).	z-atad-fmk	62-72	caspase 12	Rattus norvegicus	76-86
27847321-7	2017	Contrarily, salubrinal (the ER stress inhibitor), z-ATAD-fmk (the caspase-12 inhibitor) or CHOP shRNAs significantly attenuated AICAR-induced gallbladder cancer cell apoptosis.	z-atad-fmk	50-60	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	128-133
26998625-4	2016	Z-ATAD-FMK was used to inhibit caspase-12 activity.	z-atad-fmk	0-10	caspase 12	Mus musculus	31-41
25226445-4	2015	To explore the underlying mechanism, Z-ATAD-FMK (a selective caspase-12 inhibitor) was used to identify the key molecule involved.	z-atad-fmk	37-47	caspase 12	Rattus norvegicus	61-71
19960285-6	2010	Finally, NS3694 and Z-ATAD-FMK were employed to inhibit the formation of apoptosome complex and the activation of caspase-12, respectively, and apoptotic incidence and caspase-9 activity were assayed.	z-atad-fmk	20-30	caspase 12	Rattus norvegicus	114-124
21336971-10	2011	In addition, specific inhibitor of caspase-12 (Z-ATAD-FMK) and caspase-9 (Z-LEHD-FMK) partly suppressed cyclic stretch-induced AF cell apoptosis and the anti-apoptotic effects of the caspase inhibitors were additive.	z-atad-fmk	47-57	caspase 12	Rattus norvegicus	35-45
21336971-10	2011	In addition, specific inhibitor of caspase-12 (Z-ATAD-FMK) and caspase-9 (Z-LEHD-FMK) partly suppressed cyclic stretch-induced AF cell apoptosis and the anti-apoptotic effects of the caspase inhibitors were additive.	z-atad-fmk	47-57	caspase 8	Rattus norvegicus	35-42
19960285-9	2010	Furthermore, NS3694 and Z-ATAD-FMK dramatically suppress annular cell apoptosis and caspase-9 activity.	z-atad-fmk	24-34	caspase 9	Rattus norvegicus	84-93
18505440-5	2008	In the presence of 50 micromol/L Z-ATAD-FMK (a caspase 12 inhibitor) and 100 micromol/L Z-LEHD-FMK (a caspase 9 inhibitor), the CTX III-mediated activation of caspase 9 and caspase 3 was significantly reduced.	z-atad-fmk	33-43	caspase 9	Homo sapiens	159-168
18505440-5	2008	In the presence of 50 micromol/L Z-ATAD-FMK (a caspase 12 inhibitor) and 100 micromol/L Z-LEHD-FMK (a caspase 9 inhibitor), the CTX III-mediated activation of caspase 9 and caspase 3 was significantly reduced.	z-atad-fmk	33-43	caspase 3	Homo sapiens	173-182
30605698-8	2019	In addition, Z-ATAD-FMK (a caspase-12 inhibitor) counteracted the Cd-induced activation of caspase-12 and -3, and apoptosis.	z-atad-fmk	13-23	caspase 12	Rattus norvegicus	27-37
18280615-6	2008	Pretreatment with z-ATAD-fmk, a cell-permeable caspase-12-selective inhibitor significantly attenuated the TM-induced increase of PI fluorescence in the CA1 and DG subregion but not in area CA3.	z-atad-fmk	18-28	carbonic anhydrase 1	Rattus norvegicus	153-156
18068200-7	2008	However, pre-treatment with z-ATAD-fmk, a caspase-12 inhibitor, followed by 7kCh exposure lead to significantly increased caspase-8 activity.	z-atad-fmk	28-38	caspase 8	Homo sapiens	122-131
16338971-9	2006	The functional importance of caspase-12 activation was supported by the use of Z-ATAD-FMK, which reduced the NE-induced processing of caspase-12 and cell apoptosis, but the caspase-12, -9, and -3 inhibitors had no effects on the increase in cytosolic cytochrome c produced by NE.	z-atad-fmk	79-89	caspase 12	Rattus norvegicus	29-39
16338971-9	2006	The functional importance of caspase-12 activation was supported by the use of Z-ATAD-FMK, which reduced the NE-induced processing of caspase-12 and cell apoptosis, but the caspase-12, -9, and -3 inhibitors had no effects on the increase in cytosolic cytochrome c produced by NE.	z-atad-fmk	79-89	caspase 12	Rattus norvegicus	134-144
32788872-6	2020	Interestingly, pretreatment with the caspase-12-specific inhibitor Z-ATAD-FMK attenuated cell injury and apoptosis and decreased the levels of NLRP3, caspase-1, IL-1beta, and cleaved caspase-3 in the OGD group.	z-atad-fmk	67-77	caspase 12	Mus musculus	37-47
32788872-6	2020	Interestingly, pretreatment with the caspase-12-specific inhibitor Z-ATAD-FMK attenuated cell injury and apoptosis and decreased the levels of NLRP3, caspase-1, IL-1beta, and cleaved caspase-3 in the OGD group.	z-atad-fmk	67-77	NLR family, pyrin domain containing 3	Mus musculus	143-148
32788872-6	2020	Interestingly, pretreatment with the caspase-12-specific inhibitor Z-ATAD-FMK attenuated cell injury and apoptosis and decreased the levels of NLRP3, caspase-1, IL-1beta, and cleaved caspase-3 in the OGD group.	z-atad-fmk	67-77	caspase 1	Mus musculus	37-46
32788872-6	2020	Interestingly, pretreatment with the caspase-12-specific inhibitor Z-ATAD-FMK attenuated cell injury and apoptosis and decreased the levels of NLRP3, caspase-1, IL-1beta, and cleaved caspase-3 in the OGD group.	z-atad-fmk	67-77	interleukin 1 alpha	Mus musculus	161-169
32788872-6	2020	Interestingly, pretreatment with the caspase-12-specific inhibitor Z-ATAD-FMK attenuated cell injury and apoptosis and decreased the levels of NLRP3, caspase-1, IL-1beta, and cleaved caspase-3 in the OGD group.	z-atad-fmk	67-77	caspase 3	Mus musculus	183-192
30605698-8	2019	In addition, Z-ATAD-FMK (a caspase-12 inhibitor) counteracted the Cd-induced activation of caspase-12 and -3, and apoptosis.	z-atad-fmk	13-23	caspase 12	Rattus norvegicus	91-108