PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
28480041-7	2017	Parallel patch-clamp studies demonstrated hydroxyzine concentration-dependent inhibition of several human cardiac ion channels, including the ether-a-go-go-related gene (hERG) potassium ion channels.	Hydroxyzine	42-53	ETS transcription factor ERG	Homo sapiens	170-174
28515501-0	2017	ISMP Medication Error Report Analysis: Potential Issues with New Basal Insulin/GLP-1 Fixed Combinations Hydroxyzine-Hydroxyurea Mix-up Concomitant Use of Entresto and ACE Inhibitors Can Lead to Serious Outcomes More Outpatient Oral Cancer Drugs Should Be in Blister Packs.	Hydroxyzine	104-115	insulin	Homo sapiens	71-78
28515501-0	2017	ISMP Medication Error Report Analysis: Potential Issues with New Basal Insulin/GLP-1 Fixed Combinations Hydroxyzine-Hydroxyurea Mix-up Concomitant Use of Entresto and ACE Inhibitors Can Lead to Serious Outcomes More Outpatient Oral Cancer Drugs Should Be in Blister Packs.	Hydroxyzine	104-115	glucagon like peptide 1 receptor	Homo sapiens	79-84
26921194-5	2016	Levomepromazine and buclizine showed higher in silico binding affinities to TCTP among 12 different antihistaminic compounds including the control drugs, promethazine and hydroxyzine by using Autodock4 and AutodockTools-1.5.7.rc1.	Hydroxyzine	171-182	tumor protein, translationally-controlled 1	Homo sapiens	76-80
29149414-14	2017	Antihistaminic compounds, hydroxyzine and promethazine, inhibited cell growth of cancer cells and decreased TCTP expression of breast cancer and leukemia cells.	Hydroxyzine	26-37	tumor protein, translationally-controlled 1	Homo sapiens	108-112
16105724-5	2005	Hydroxyzine inhibited the efflux of P-gp substrates like etoposide and chlorpheniramine across the olfactory mucosa.	Hydroxyzine	0-11	phosphoglycolate phosphatase	Bos taurus	36-40
26163869-2	2015	In the current study, a UPLC-MS/MS method was developed and validated to quantify hydroxyzine hydrochloride in an extracellular solution used in a hERG assay in concentrations ranging from 0.01 to 10muM (4.5ng/ml-4.5mug/ml).	Hydroxyzine	82-107	ETS transcription factor ERG	Homo sapiens	147-151
22786524-20	2012	Women receiving the antihistamine hydroxyzine were more likely to express satisfaction with pain relief compared with the antihistamine promethazine (RR 1.21; 95% CI 1.02 to 1.43, one trial, 289 women).	Hydroxyzine	34-45	ribonucleotide reductase catalytic subunit M1	Homo sapiens	150-154
22188412-10	2012	Altering functional P-gp in the gut is likely to influence absorption of some sedating antihistamines such as dimenhydrinate and hydroxyzine and most less-sedating antihistamines except loratadine.	Hydroxyzine	129-140	phosphoglycolate phosphatase	Homo sapiens	20-24
21892192-0	2011	Effects of the histamine H(1) receptor antagonist hydroxyzine on hERG K(+) channels and cardiac action potential duration.	Hydroxyzine	50-61	histamine receptor H1	Homo sapiens	15-38
21892192-0	2011	Effects of the histamine H(1) receptor antagonist hydroxyzine on hERG K(+) channels and cardiac action potential duration.	Hydroxyzine	50-61	ETS transcription factor ERG	Homo sapiens	65-69
21892192-1	2011	AIM: To investigate the effects of hydroxyzine on human ether-a-go-go-related gene (hERG) channels to determine the electrolphysiological basis for its proarrhythmic effects.	Hydroxyzine	35-46	ETS transcription factor ERG	Homo sapiens	84-88
21892192-5	2011	Hydroxyzine (0.03-3 mumol/L) blocked both the steady-state and tail hERG currents.	Hydroxyzine	0-11	ETS transcription factor ERG	Homo sapiens	68-72
21892192-9	2011	CONCLUSION: The results suggest that hydroxyzine could block hERG channels and prolong APD.	Hydroxyzine	37-48	ETS transcription factor ERG	Homo sapiens	61-65
19672097-10	2010	SUN-1334H, cetirizine and hydroxyzine caused comparable inhibition of NLF leukocytes, IL-4 and total protein concentrations.	Hydroxyzine	26-37	interleukin 4	Homo sapiens	86-90
19057127-0	2008	Hydroxyzine, a first generation H(1)-receptor antagonist, inhibits human ether-a-go-go-related gene (HERG) current and causes syncope in a patient with the HERG mutation.	Hydroxyzine	0-11	potassium voltage-gated channel subfamily H member 2	Homo sapiens	101-105
19057127-0	2008	Hydroxyzine, a first generation H(1)-receptor antagonist, inhibits human ether-a-go-go-related gene (HERG) current and causes syncope in a patient with the HERG mutation.	Hydroxyzine	0-11	potassium voltage-gated channel subfamily H member 2	Homo sapiens	156-160
19057127-2	2008	In this paper, we will report a case of drug-induced long QT syndrome associated with an H(1)-receptor antagonist, hydroxyzine, in which a mutation was identified in the HERG gene.	Hydroxyzine	115-126	potassium voltage-gated channel subfamily H member 2	Homo sapiens	170-174
19057127-7	2008	Hydroxyzine concentration-dependently inhibited both wild-type (WT) and WT/A614V-HERG K(+) currents.	Hydroxyzine	0-11	potassium voltage-gated channel subfamily H member 2	Homo sapiens	81-85
17447421-2	2006	Hydroxyzine was found to be a competitive inhibitor of MAO-B (Ki - 38 microM), whereas it had a low potency towards MAO-A (IC50 > 630 microM).	Hydroxyzine	0-11	monoamine oxidase B	Bos taurus	55-60
17447421-2	2006	Hydroxyzine was found to be a competitive inhibitor of MAO-B (Ki - 38 microM), whereas it had a low potency towards MAO-A (IC50 > 630 microM).	Hydroxyzine	0-11	monoamine oxidase A	Bos taurus	116-121
9809861-8	1998	Thus, hydroxyzine is a useful treatment for GAD.	Hydroxyzine	6-17	glutamate decarboxylase 1	Homo sapiens	44-47
14502547-2	2003	The purpose of this study was to determine the importance of Pgp-mediated efflux on the in vivo brain distribution of the non-sedating antihistamine cetirizine (Zyrtec), and the structurally related sedating (first-generation) antihistamine hydroxyzine (Atarax).	Hydroxyzine	254-260	phosphoglycolate phosphatase	Mus musculus	61-64
14502547-5	2003	In contrast, hydroxyzine was not a Pgp substrate in vitro (B-->A/A-->B ratio = 0.86), had high passive permeability (PappB-->A + GF120918 = 296 nm/s), and had brain-to-free plasma concentration ratios >73 in both Pgp-deficient and wild-type mice.	Hydroxyzine	13-24	phosphoglycolate phosphatase	Mus musculus	225-228
14502547-6	2003	These studies demonstrate that Pgp-mediated efflux and passive permeability contribute to the low cetirizine brain concentrations in mice and that these properties account for the differences in the sedation side-effect profiles of cetirizine and hydroxyzine.	Hydroxyzine	247-258	phosphoglycolate phosphatase	Mus musculus	31-34
15489264-8	2004	We show that some antihistaminic compounds (hydroxyzine and promethazine) and other pharmacological compounds with a related structure (including thioridazine and sertraline) kill tumor cells and significantly decrease the level of TCTP.	Hydroxyzine	44-55	tumor protein, translationally-controlled 1	Homo sapiens	232-236
11824769-0	2002	Coma and apnea in a dog with hydroxyzine toxicosis.	Hydroxyzine	29-40	COMA	Homo sapiens	0-4
9616188-1	1998	Classic antihistamines, namely diphenhydramine, chlorpheniramine, clemastine, perphenazine, hydroxyzine, and tripelennamine, share structural features with substrates and inhibitors of the polymorphic cytochrome P450 (CYP) isozyme CYP2D6.	Hydroxyzine	92-103	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	201-216
9066941-5	1997	Macrophage migration inhibiting factor (MIF) assay with hydroxyzine hydrochloride was positive.	Hydroxyzine	56-81	macrophage migration inhibitory factor	Homo sapiens	40-43
9417395-14	1997	Levels of anxiety (HARS et Zung) were significantly improved in hydroxyzine 50 mg group (p < 0.007) and in hydroxyzine 25 mg group (p < 0.012) but not in placebo group.	Hydroxyzine	64-75	histidyl-tRNA synthetase 1	Homo sapiens	19-23
9417395-14	1997	Levels of anxiety (HARS et Zung) were significantly improved in hydroxyzine 50 mg group (p < 0.007) and in hydroxyzine 25 mg group (p < 0.012) but not in placebo group.	Hydroxyzine	110-121	histidyl-tRNA synthetase 1	Homo sapiens	19-23
8603281-6	1995	Hydroxyzine and diphenhydramine increased the mean P300 latency and somnolence significantly (P < .05) compared with baseline; increases were observed in most, but not all subjects.	Hydroxyzine	0-11	E1A binding protein p300	Homo sapiens	51-55
8792380-8	1996	At the central (Cz) and frontal (Fz) electrodes, diphenhydramine and hydroxyzine increased the P300 latency significantly (P < 0.05) compared to baseline.	Hydroxyzine	69-80	E1A binding protein p300	Homo sapiens	95-99
8792380-11	1996	In children, diphenhydramine and hydroxyzine are effective H1-receptor antagonists, but both these medications cause CNS dysfunction, as evidenced by increased P300 latency, a measure of cognitive function, and by increased subjective somnolence.	Hydroxyzine	33-44	E1A binding protein p300	Homo sapiens	160-164
9413893-7	1997	Chlorpromazine, imipramine, fluoxetine, doxepin, amitriptyline and hydroxyzine used in the practice of dermatology may exert their therapeutic effects by modulating skin PKC activity.	Hydroxyzine	67-78	proline rich transmembrane protein 2	Homo sapiens	170-173
8603281-7	1995	Hydroxyzine increased P300 latency and somnolence significantly compared with placebo and with cetirizine.	Hydroxyzine	0-11	E1A binding protein p300	Homo sapiens	22-26
7913608-2	1994	First-generation histamine H1-receptor antagonists, such as diphenhydramine, triprolidine, hydroxyzine or chlorpheniramine (chlorphenamine), frequently cause somnolence or other CNS adverse effects.	Hydroxyzine	91-102	histamine receptor H1	Homo sapiens	17-38
7655991-3	1995	Oxatomide, hydroxyzine and cetirizine inhibit the antigen induced beta-hexosaminidase release.	Hydroxyzine	11-22	O-GlcNAcase	Rattus norvegicus	66-85
1981354-2	1990	Cetirizine, a piperazine derivative and carboxylated metabolite of hydroxyzine, is a potent histamine H1-receptor antagonist with antiallergic properties.	Hydroxyzine	67-78	histamine receptor H1	Homo sapiens	92-113
7510611-2	1993	Cetirizine, the carboxylated metabolite of hydroxyzine, is a specific and long-acting histamine H1-receptor antagonist.	Hydroxyzine	43-54	histamine receptor H1	Homo sapiens	86-107
34284240-0	2021	The histamine H1 receptor antagonist hydroxyzine enhances sevoflurane and propofol anesthesia: A quantitative EEG study.	Hydroxyzine	37-48	histamine receptor H1	Homo sapiens	4-25
2982914-13	1985	Although erythema at C5a injection sites was reduced by pretreating volunteers with hydroxyzine, whealing reactions and cellular infiltrates in biopsies were unaffected by this H1-antihistamine.	Hydroxyzine	84-95	complement C5a receptor 1	Homo sapiens	21-24
2729484-8	1989	Hot/Ice patients required 53% less injectable Demerol and 67% less oral Vistaril than patients in the control group.	Hydroxyzine	72-80	alcohol dehydrogenase iron containing 1	Homo sapiens	0-3
4646075-0	1972	[In vitro inhibitory effect of hydroxyzine hydrochloride on human plasma cholinesterase].	Hydroxyzine	31-56	butyrylcholinesterase	Homo sapiens	73-88
13414323-0	1956	[Effects of chlorbenzhydryl-hydroxy-ethoxy-diethylamine (hydroxyzine) on gastric hypersecretion after the administration of insulin].	Hydroxyzine	57-68	insulin	Homo sapiens	124-131
30028993-10	2018	Thus we report the existence of a novel target for some related piperazines including cinnarizine and hydroxyzine, i.e. specific inhibition of mTORC1 activity.	Hydroxyzine	102-113	CREB regulated transcription coactivator 1	Mus musculus	143-149
30028993-11	2018	Since mTOR inhibition is a general anti-cancer strategy, and mTORC1 is specifically activated in some tumors, we suggest the piperazine scaffold, including cinnarizine and hydroxyzine, could be proposed for rational therapy in tumors in which mTORC1 is specifically activated.	Hydroxyzine	172-183	CREB regulated transcription coactivator 1	Mus musculus	243-249
33309272-7	2021	Although mechanisms by which specific antihistamines exert antiviral effects is not clear, hydroxyzine, and possibly azelastine, bind Angiotensin Converting Enzyme-2 (ACE2) and the sigma-1 receptor as off-targets.	Hydroxyzine	91-102	angiotensin converting enzyme 2	Homo sapiens	134-165
33309272-7	2021	Although mechanisms by which specific antihistamines exert antiviral effects is not clear, hydroxyzine, and possibly azelastine, bind Angiotensin Converting Enzyme-2 (ACE2) and the sigma-1 receptor as off-targets.	Hydroxyzine	91-102	angiotensin converting enzyme 2	Homo sapiens	167-171
30863716-2	2019	For alleviation of allergic symptoms, H1R antagonists are therapeutic drugs; of which the most frequently prescribed are second generation drugs, such as; Cetirizine, Loratadine, Hydroxyzine, Desloratadine, Bepotastine, Acrivastine and Rupatadine.	Hydroxyzine	179-190	histamine receptor H1	Homo sapiens	38-41
28934541-4	2018	All 3 patients presented with blistering around their incisions within 2 weeks of surgery and responded to treatment involving removal of the offending agent and use of oral diphenhydramine and hydroxyzine and topical triamcinolone.	Hydroxyzine	194-205	paired box 5	Homo sapiens	0-5